Durability of immunity to diphtheria, tetanus and poliomyelitis after a three dose immunization schedule completed in the first eight months of life.
Blood samples were obtained from school entrants whose primary immunization schedule had consisted of three doses of DT or DTP vaccine and three doses of OPV all given before the age of 8 months. The sera were separated and assayed for diphtheria antitoxin, tetanus antitoxin and antibodies to the three serotypes of poliovirus. The results of the assays showed that the abbreviated three dose schedule induced satisfactory immunity to all five infections until school entry and that a reinforcing dose at 18 months was unnecessary.
Jones
A E
AE
Central Manchester Health Authority, UK.
Johns
A
A
Magrath
D I
DI
Melville-Smith
M
M
Sheffield
F
F
D000914:Antibodies, Viral / Q000032:analysis; D004165:Diphtheria / Q000276:immunology*; D004168:Diphtheria Toxoid / Q000008:administration & dosage*; D022422:Diphtheria-Tetanus Vaccine; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage*; D004338:Drug Combinations / Q000008:administration & dosage; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D007231:Infant, Newborn; D011051:Poliomyelitis / Q000276:immunology*; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage*; D013742:Tetanus / Q000276:immunology*; D013745:Tetanus Toxoid / Q000008:administration & dosage*
D000914:Antibodies, Viral; D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations; D011055:Poliovirus Vaccine, Oral; D013745:Tetanus Toxoid