[Biological effects of coordinated compounds of transitional metals. 7. Antiviral activity of 4-methyl-2-aminopyridine palladium chloride against herpes simplex virus type 1 and type 2 in vitro and in vivo].
4-Methyl-2-amino-pyridine-palladium chloride (MAP) showed an antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a serum-free medium under in vitro conditions. The replication of these viruses on primary rabbit testes cells was completely suppressed by 10(-5) M/l MAP. In animal tests using ABD2-mice the course of HSV-1 and HSV-2 encephalitis was not influenced by MAP indicated by mean survival time and lethality.
Wutzler
P
P
Medizinische Akademie Erfurt, Institut für Medizinische Mikrobiologie, DDR.
Thiel
K D
KD
Tonew
M
M
Tonew
E
E
Schröer
H P
HP
Stelzner
A
A
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002478:Cells, Cultured; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy*; D051379:Mice; D009942:Organometallic Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D010847:Picolines / Q000494:pharmacology* / Q000627:therapeutic use; D018139:Simplexvirus / Q000187:drug effects*; D013047:Specific Pathogen-Free Organisms
D000998:Antiviral Agents; D009942:Organometallic Compounds; D010847:Picolines; C032537:4-methyl-2-aminopyridine-palladium chloride
Uber biologische Wirkungen von Koordinationsverbindungen der Ubergangsmetalle. 7. Zur antiviralen Wirksamkeit von 4-Methyl-2-amino-pyridinpalladiumchlorid gegenüber Herpes simplex-Virus Typ 1 und Typ 2 in vitro und in vivo.