title: Langerhans cells in vaccinia virus infection in mouse skin.
abstract: Langerhans cells function as potent antigen-presenting cells in the epidermis. They were shown to play an essential role in the mechanisms of defense of the skin against viral infections. In the present study, the response of Langerhans cells to infection of the skin with vaccinia virus was investigated. Decrease in Langerhans cell density in the skin was accompanied by an increase in the pathogenicity of the WR and Noguchi but not of the Lister strain of vaccinia virus. Langerhans cell density was shown to increase rapidly at the site of inoculation with the two pathogenic strains of vaccinia virus.
authors.affiliation: Department of Molecular Virology, Faculty of Medicine, Hebrew University, Jerusalem, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Becker
authors.forename: E
authors.initials: E
authors.lastname: Sprecher
mesh_terms: D000818:Animals; D002452:Cell Count; D007801:Langerhans Cells / Q000502:physiology*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D011239:Prednisolone; D012874:Skin Diseases, Infectious / Q000209:etiology / Q000276:immunology*; D013045:Species Specificity; D014615:Vaccinia / Q000276:immunology*; D014616:Vaccinia virus / Q000276:immunology / Q000472:pathogenicity; D014765:Viral Vaccines
chemical_list: D014765:Viral Vaccines; D011239:Prednisolone