The effect of gold sodium thiomalate in adult Swiss/A2G mice infected with togaviruses and flaviviruses.
Treatment of adult mice with gold sodium thiomalate made the normally non-lethal Semliki Forest virus and Sindbis virus infections lethal and increased the virulence of Langat and West Nile viruses. These changes were associated with an enhanced virus invasion of the brain. Depression of the humoral antibody response was not observed.
Mehta
S
S
Neurovirology Unit, Rayne Institute, London, U.K.
Webb
H E
HE
D000818:Animals; D000917:Antibody Formation; D001921:Brain / Q000382:microbiology; D005416:Flavivirus / Q000254:growth & development / Q000276:immunology; D006052:Gold Sodium Thiomalate / Q000494:pharmacology*; D008264:Macrophages / Q000382:microbiology; D008566:Membranes / Q000503:physiopathology; D051379:Mice; D014035:Togaviridae / Q000254:growth & development / Q000276:immunology; D014036:Togaviridae Infections / Q000276:immunology / Q000382:microbiology* / Q000503:physiopathology; D014779:Virus Replication
D006052:Gold Sodium Thiomalate