Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat.
We have examined the effects of ketamine and kynurenate on the initial response and frequency dependent potentiation of response (wind-up) of class 2 neurones of the rat dorsal horn induced by repeated electrical stimulation of their receptive fields. Iontophoretic kynurenate reduced both the initial response and the wind-up. Iontophoretic or intravenous ketamine had no consistent effect on the initial response but consistently reduced wind-up. N-Methylaspartate receptors therefore appear to contribute to the wind-up, but not the initial response, of class 2 neurones in the rat.
Davies
S N
SN
Department of Physiology, Royal Veterinary College, London, U.K.
Lodge
D
D
D000818:Animals; D004558:Electric Stimulation; D007275:Injections, Intravenous; D007478:Iontophoresis; D007649:Ketamine / Q000494:pharmacology; D007736:Kynurenic Acid / Q000494:pharmacology; D009474:Neurons / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects / Q000502:physiology*
D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D007649:Ketamine; D007736:Kynurenic Acid