title: Cytotoxic activity of aryl and heteroaroxylazoxy derivatives.
abstract: Synthesis of aryl and heteroarylazocyanides, azoxyesters and azoxysulphones, was carried out by the action of appropriate reagents on the corresponding nitroso derivatives and arylazoxyamides were obtained by hydrolysis of the corresponding azoxycyanides. Cytotoxic activity was assessed utilizing cultured P388 leukemia cells. Most of the compounds tested showed a marked cytotoxicity at concentrations below 1 micrograms/ml.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica dell'Università, Torino, Italia.
authors.forename: R
authors.initials: R
authors.lastname: Fruttero
authors.forename: R
authors.initials: R
authors.lastname: Calvino
authors.forename: P
authors.initials: P
authors.lastname: Aresca
authors.forename: R
authors.initials: R
authors.lastname: Bossa
authors.forename: I
authors.initials: I
authors.lastname: Galatulas
authors.forename: M
authors.initials: M
authors.lastname: Ninci
mesh_terms: D000818:Animals; D001391:Azo Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects*; D003486:Cyanides / Q000138:chemical synthesis / Q000494:pharmacology*; D004952:Esters / Q000138:chemical synthesis / Q000494:pharmacology; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects*
chemical_list: D001391:Azo Compounds; D003486:Cyanides; D004952:Esters; D013450:Sulfones