Arthritis in patients with psoriasis is associated with an immunoglobulin gene polymorphism.
Using a DNA probe for the switch region of immunoglobulin heavy chain genes, together with the restriction endonuclease Sst I, we detected a particular polymorphic DNA pattern in 17 of 28 patients (60.7%) with psoriatic arthropathy but in only 5 of 41 patients (12.2%) with psoriasis alone. Our findings suggest that genes in the immunoglobulin region confer susceptibility to the development of arthropathy in patients with psoriasis.
Sakkas
L I
LI
Rheumatology Unit, United Medical School, Guy's Hospital, London, UK.
Demaine
A G
AG
Panayi
G S
GS
Welsh
K I
KI
D000328:Adult; D001168:Arthritis / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004720:Endonucleases / Q000235:genetics; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000235:genetics*
D007143:Immunoglobulin Heavy Chains; D004247:DNA; D004720:Endonucleases