Studies on the formation and stability of isoindoles derived from amino acids, o-phthalaldehyde and N-acetyl-L-cysteine.
A kinetic-spectrophotometric study is performed on the formation and degradation of the isoindole derivatives of amino acids with o-phthalaldehyde and N-acetyl-L-cysteine. The experimental and structural factors which affect the formation and stability of the compounds are considered, and the results are compared with those obtained for mercaptoethanol. N-Acetyl-L-cysteine derivatives are highly stable, not requiring a strict control of the time of reaction as in the case of mercaptoethanol.
García Alvarez-Coque
M C
MC
Departamento de Química Analítico, Facultad de Química, Universidad de Valencia, Spain.
Medina Hernández
M J
MJ
Villanueva Camañas
R M
RM
Mongay Fernández
C
C
D000111:Acetylcysteine / Q000031:analogs & derivatives*; D000447:Aldehydes; D000596:Amino Acids; D002851:Chromatography, High Pressure Liquid; D007211:Indoles / Q000032:analysis*; D007532:Isoleucine; D007700:Kinetics; D008623:Mercaptoethanol; D013050:Spectrometry, Fluorescence; D009764:o-Phthalaldehyde
D000447:Aldehydes; D000596:Amino Acids; D007211:Indoles; D007532:Isoleucine; D008623:Mercaptoethanol; D009764:o-Phthalaldehyde; D000111:Acetylcysteine