Renin and inactive renin (prorenin) in the plasma of patients with malignant renal tumours.
Plasma active and inactive renin (porenin) concentrations were measured in 26 adults with renal carcinoma and 8 children with nephroblastoma. In patients with carcinoma, plasma total renin concentration was slightly raised in 8 patients and markedly in one, in whom the increase was due to a more than 10-fold excess of inactive renin. Total renin concentration was raised in 7 out of 8 cases of nephroblastoma, the increase being due to excess inactive renin. It is likely that this represented oversecretion of a renin precursor, as inactive renin from the plasma of a patient with renal carcinoma showed similar biochemical characteristics to pure human prorenin.
Leckie
B J
BJ
MRC Blood Pressure Unit, Western Infirmary, Glasgow, U.K.
McIntyre
G D
GD
Millan
W D
WD
Lindop
G B
GB
Carachi
R
R
D000328:Adult; D002292:Carcinoma, Renal Cell / Q000097:blood*; D002648:Child; D004792:Enzyme Precursors / Q000097:blood*; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood*; D012083:Renin / Q000097:blood*; D009396:Wilms Tumor / Q000097:blood*
D004792:Enzyme Precursors; D012083:Renin