title: [Morphofunctional changes in a culture of pancreatic islet cells from newborn piglets as affected by Coxsackie B3 viruses].
abstract: The direct influence of Coxsackie virus B-3 and its selected variants Abent+ and Abent- on the function and structure of neonatal pig pancreatic islet cells in monolayer cultures was studied. The viruses under study possessed cytopathogenic activity and were capable of reproduction. The Abent- variant of Coxsackie virus B-3 possessed the most pronounced cytopathogenic activity. Direct correlation between virus reproduction and insulin concentration in a culture medium was established.
authors.forename: V P
authors.initials: VP
authors.lastname: Komissarenko
authors.forename: I S
authors.initials: IS
authors.lastname: Turchin
authors.forename: V P
authors.initials: VP
authors.lastname: Shirobokov
authors.forename: V V
authors.initials: VV
authors.lastname: Zemlianskiĭ
authors.forename: T B
authors.initials: TB
authors.lastname: Zhurba
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D029822:Enterovirus B, Human / Q000472:pathogenicity* / Q000502:physiology; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D009154:Mutation; D013552:Swine; D013997:Time Factors; D014779:Virus Replication
chemical_list: D007328:Insulin
vernacular_title: Morfofunktsional'nye izmeneniia v kul'ture ostrovkovykh kletok podzheludochnoĭ zhelezy novorozhdennykh porosiat pod vliianiem virusov Koksaki B3.