title: Spin-labeled antitumor derivatives of podophyllotoxin.
abstract: Three spin-labeled antitumor derivatives of podophyllotoxin, containing an iminoxyl radical, have been synthesized. Preliminary pharmacological tests showed that these derivatives have significant antitumor activity in several experimental tumor systems with a marked decrease in toxicity compared with the parent compound. The relative intensities of ESR signals of these spin-labeled compounds were linearly proportional to their concentrations, the levels of the agent in blood and organs of mice or rabbits can be measured via ESR spectrometry.
authors.affiliation: Department of Chemistry, Lanzhou University.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Chen
authors.forename: C J
authors.initials: CJ
authors.lastname: Zhang
authors.forename: X A
authors.initials: XA
authors.lastname: Tian
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D051379:Mice; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D011817:Rabbits; D013113:Spin Labels; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents; D013113:Spin Labels; D011034:Podophyllotoxin