title: Expression of Tac antigen by non-Hodgkin's lymphomas.
abstract: Anti-Tac is a monoclonal antibody that appears to recognize the interleukin-2 receptor. With the use of a frozen-section immunoperoxidase technic, a large series of non-Hodgkin's lymphomas were investigated for the presence of Tac-antigen on neoplastic cells. Approximately one-fourth of cases expressed the Tac antigen, including 27% of B-lineage lymphomas, 6% of the T-lineage lymphomas, and three of four cases of Ki-1-expressing lymphoma. The B-lineage lymphomas with the highest incidence of Tac antigen expression were the large cell lymphomas, both diffuse and follicular, where about one-half of cases expressed the Tac antigen. All major categories of lymphoma expressed Tac except plasma-cytoma/myeloma, small noncleaved cell (Burkitt's and non-Burkitt's), and lymphoblastic malignancies.
authors.affiliation: Department of Pathology, Stanford University Medical Center, California 94305.
authors.forename: L M
authors.initials: LM
authors.lastname: Weiss
authors.forename: S A
authors.initials: SA
authors.lastname: Michie
authors.forename: L J
authors.initials: LJ
authors.lastname: Medeiros
authors.forename: J G
authors.initials: JG
authors.lastname: Strickler
authors.forename: C F
authors.initials: CF
authors.lastname: Garcia
authors.forename: R A
authors.initials: RA
authors.lastname: Warnke
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000032:analysis*; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7