Induction of an oncofetal marker protein upon X-radiation of rat mammary glands.
Fifty-day-old female Sprague--Dawley rats were given carcinogenic and sub-carcinogenic doses of X-radiation to the mammary glands to evaluate the induction of a 60-kDa oncofetal protein (OFP-60). This protein has previously been shown to be produced in the target organ and released to circulation during chemical carcinogenesis and tumorigenesis. In a time course experiment, the mammary glands of the rats were irradiated with a single dose of 1.85 gray (Gy). The OFP-60 marker protein was detected in peripheral blood at 21 days post-irradiation. Irradiation of the mammary gland with single X-ray doses ranging from 0.22 to 1.85 Gy produced a linear relationship between X-ray dose and plasma concentration of OFP-60 determined at 21 days post-treatment. This initiation-related parameter correlates with the known linear relationship between dose of X-radiation and potential tumor incidence.
Schumm
D E
DE
Cancer Center, Ohio State University, Columbus 43210.
Hatch
J M
JM
Webb
T E
TE
D000818:Animals; D000951:Antigens, Neoplasm / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008321:Mammary Glands, Animal / Q000528:radiation effects*; D008325:Mammary Neoplasms, Experimental / Q000276:immunology; D008970:Molecular Weight; D009381:Neoplasms, Radiation-Induced / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D014965:X-Rays
D000951:Antigens, Neoplasm; C031192:oncofetal antigens