title: The adenovirus tripartite leader may eliminate the requirement for cap-binding protein complex during translation initiation.
abstract: The adenovirus tripartite leader is a 200-nucleotide 5' noncoding region that is found on all late viral mRNAs. This segment is required for preferential translation of viral mRNAs at late times during infection. Most tripartite leader-containing mRNAs appear to exhibit little if any requirement for intact cap-binding protein complex, a property previously established only for uncapped poliovirus mRNAs and capped mRNAs with minimal secondary structure. The tripartite leader also permits the translation of mRNAs in poliovirus-infected cells in the apparent absence of active cap-binding protein complex and does not require any adenovirus gene products for this activity. The preferential translation of viral late mRNAs may involve this unusual property.
authors.affiliation: Department of Biochemistry, New York University Medical Center, New York 10016.
authors.forename: P J
authors.initials: PJ
authors.lastname: Dolph
authors.forename: V
authors.initials: V
authors.lastname: Racaniello
authors.forename: A
authors.initials: A
authors.lastname: Villamarin
authors.forename: F
authors.initials: F
authors.lastname: Palladino
authors.forename: R J
authors.initials: RJ
authors.lastname: Schneider
mesh_terms: D000260:Adenoviruses, Human / Q000235:genetics*; D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D002460:Cell Line; D006801:Humans; D046911:Macromolecular Substances; D009690:Nucleic Acid Conformation; D017955:Poliovirus / Q000235:genetics; D014176:Protein Biosynthesis; D039381:RNA Cap-Binding Proteins; D012333:RNA, Messenger / Q000235:genetics*; D012367:RNA, Viral / Q000235:genetics*; D013997:Time Factors; D014764:Viral Proteins / Q000235:genetics
chemical_list: D002352:Carrier Proteins; D046911:Macromolecular Substances; D039381:RNA Cap-Binding Proteins; D012333:RNA, Messenger; D012367:RNA, Viral; D014764:Viral Proteins