title: Growth factors and receptors of lymphocytes.
abstract: To understand molecular mechanisms of clonal expansion of lymphocytes we have isolated cDNA clones for two lymphokines, interleukins (IL) 4 and 5 that induce proliferation and maturation of B-lymphocytes. Structures of IL-4 and IL-5 revealed a remote homology with other lymphokines such as IL-3 and gamma-interferon. IL-4 and IL-5 were shown to affect not only B-lymphocytes but also T-lymphocytes and several other cells derived from bone marrow stem cells. We have also studied the structure and function of the IL-2 receptor: our focus was the molecular basis for the high and low affinity states of the receptor encoded by the identical cDNA. We propose the affinity conversion model that the high-affinity state of the IL-2 receptor is a ternary complex of IL-2, the IL-2 receptor, and a postulated "converter protein", which is fewer in number than the receptors.
authors.affiliation: Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kinashi
authors.forename: Y
authors.initials: Y
authors.lastname: Noma
authors.forename: C
authors.initials: C
authors.lastname: Azuma
authors.forename: S
authors.initials: S
authors.lastname: Kondo
authors.forename: T
authors.initials: T
authors.lastname: Tanabe
authors.forename: M
authors.initials: M
authors.lastname: Konishi
authors.forename: M
authors.initials: M
authors.lastname: Kinoshita
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Ogura
mesh_terms: D000818:Animals; D002455:Cell Division; D003001:Cloning, Molecular; D004247:DNA; D005815:Genetic Code; D006133:Growth Substances / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D006801:Humans; D015847:Interleukin-4; D015848:Interleukin-5; D007378:Interleukins / Q000235:genetics; D008214:Lymphocytes / Q000166:cytology* / Q000502:physiology; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism; D015375:Receptors, Interleukin-2
chemical_list: D006133:Growth Substances; D015848:Interleukin-5; D007378:Interleukins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D015847:Interleukin-4; D004247:DNA