In vitro antiviral activity of a saponin from Anagallis arvensis, Primulaceae, against herpes simplex virus and poliovirus.
The antiviral activity of a triterpene saponin isolated from Anagallis arvensis, Primulaceae, was studied in vitro against several viruses including herpes simplex type 1, adenovirus type 6, vaccinia, vesicular stomatitis and poliovirus. The drug was found to inhibit the replication of herpes simplex virus type 1 and poliovirus type 2 as shown by inhibition of cytopathic effect and reduction of virus production. The action was not due to a virucidal effect but might involve inhibition of virus-host cell attachment. Single cycle experiments indicated that saponin interfered with both early and late events of herpes virus replication.
Amoros
M
M
Laboratoire de Pharmacognosie, Faculté de Pharmacie, Rennes, France.
Fauconnier
B
B
Girre
R L
RL
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D003588:Cytopathogenic Effect, Viral; D008854:Microscopy, Electron; D017955:Poliovirus / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D012503:Saponins / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D014315:Triterpenes / Q000494:pharmacology; D014709:Vero Cells
D000998:Antiviral Agents; D012503:Saponins; D014315:Triterpenes