First available results of long-term carcinogenicity bioassay on detergency zeolites (MS 4A and MS 5A).
Long-term experimental carcinogenicity bioassay was carried out on MS 4A and MS 5A zeolites. The materials were tested on Sprague-Dawley rats by intraperitoneal, intrapleural, and subcutaneous injection of 25 mg in 1 ml of H2O. The results of this bioassay (the onset of one peritoneal mesothelioma in a male rat treated by intraperitoneal injection of zeolite MS 4A) calls for further and more sophisticated tests on zeolites used as detergents.
Maltoni
C
C
Institute of Oncology F. Addarii, Bologna, Italy.
Minardi
F
F
D000538:Aluminum Silicates / Q000633:toxicity*; D000818:Animals; D001681:Biological Assay; D003902:Detergents / Q000633:toxicity*; D008654:Mesothelioma / Q000139:chemically induced*; D009152:Mutagenicity Tests; D010534:Peritoneal Neoplasms / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D013501:Surface-Active Agents / Q000633:toxicity*; D017641:Zeolites
D000538:Aluminum Silicates; D003902:Detergents; D013501:Surface-Active Agents; D017641:Zeolites