Localization of binding sites for ANF in the rat mammary gland.
The localization of ANF binding sites in the mammary gland has been performed in virgin and lactating rats using an in vitro autoradiographic procedure performed on slide-mounted frozen sections. The radioligand used was rat [125I]ANF (99-126). It was demonstrated that specific ANF binding sites were present in the secretory cells and also to a lesser extent in acinar lumen. These results suggest that ANF could play some role in the production of fluid during lactation.
Pelletier
G
G
MRC Group in Molecular Endocrinology, Le Centre Hospitalier de l'Université Laval, Ste-Foy, Quebec, Canada.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D001667:Binding, Competitive; D005260:Female; D006651:Histocytochemistry; D007700:Kinetics; D008321:Mammary Glands, Animal / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D017461:Receptors, Atrial Natriuretic Factor; D011956:Receptors, Cell Surface / Q000378:metabolism*
D011956:Receptors, Cell Surface; D009320:Atrial Natriuretic Factor; D017461:Receptors, Atrial Natriuretic Factor