[The tumor marker CA 15-3 in breast cancer in serum and cell compartments as an additional prognostic criterion].
In 86 woman patients having a histologically confirmed carcinoma of the breast we examined during primary treatment the CA 15-3 data in the compartments serum, cytosol and a membrane fraction. Low CA 15-3 levels in the serum combined with high concentrations in cytosol and the membrane fraction were associated with a good prognosis, whereas a poor prognosis was seen in case of high serum values and simultaneously low values in the cytosol and the membrane fraction. Hence, it seems that prognoses of the future course of the disease are possible if the CA 15-3 values are simultaneously determined in the serum, in cytosol and in a membrane fraction.
Seitzer
D
D
Klinik und Poliklinik für Geburthilfe und Frauenheilkunde A, Westfälische Wilhelms-Universität Münster.
Brandt
B
B
Beller
F K
FK
Assmann
G
G
D000328:Adult; D000951:Antigens, Neoplasm / Q000378:metabolism*; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology; D002451:Cell Compartmentation; D002462:Cell Membrane / Q000648:ultrastructure; D003600:Cytosol / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor
Der Tumormarker CA 15-3 beim Mammakarzinom in Serum und Zellkompartimenten als ein zusätzliches prognostisches Kriterium.