Nephritogenic glycoprotein. XII. Focal glomerulonephritis with myeloid bodies produced in rats by synthetic analogues of the glycopeptide, nephritogenoside.
Glomerular lesions were successfully induced in rats by a single footpad injection of synthetic analogues of nephritogenoside [alpha-Glc-(1----6)-alpha-Glc-(1-NHCO-Asn, and -Gln)]. Characteristic morphological changes of these glomerular lesions are (1) focal glomerulonephritis (FGN) and (2) the appearance of myeloid bodies in the epithelial cells of the podocytes. FGN produced by a single injection of the synthetic analogues of nephritogenoside may provide an experimental animal model of this potentially diffuse disease, since morphological changes in the early stage of sclerosing glomerulonephritis (end-stage kidney) induced by a single footpad injection of natural nephritogenoside are often identical to those of FGN.
Shibata
S
S
Clinical Research Institute, National Medical Center, Tokyo, Japan.
Okada
M
M
Natori
Y
Y
Shindo
N
N
Oshima
M
M
D000818:Animals; D001216:Asparagine / Q000031:analogs & derivatives*; D002478:Cells, Cultured; D004195:Disease Models, Animal; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000473:pathology; D005973:Glutamine / Q000031:analogs & derivatives*; D006020:Glycopeptides; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D007678:Kidney Glomerulus / Q000648:ultrastructure*; D007687:Kidney Tubules, Proximal / Q000648:ultrastructure; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014312:Trisaccharides
D006020:Glycopeptides; D014312:Trisaccharides; D005973:Glutamine; D001216:Asparagine; C027788:glucosyl-glucosyl-glucosyl-asparagine; C054407:glycotriosyl glutamine