title: Unusual biochemistry of changes in neuron membrane permeability evoked by cAMP.
abstract: Influence of different metabolic poisons on cAMP-evoked neuron membrane permeability is investigated. Drugs preventing cAMP binding with R subunits of protein kinase decrease the cAMP-evoked current, but the inhibitor of the C subunit. H8, has no effect. The cAMP-dependent current is increased by uncouplers and decreased by inhibitors of glycolysis and oxidative phosphorylation. The mechanism of cAMP action on neuron permeability is discussed.
authors.affiliation: Institute for Information Transmission Problems, Acad. Sci. USSR, Moscow.
authors.forename: E A
authors.initials: EA
authors.lastname: Liberman
authors.forename: S V
authors.initials: SV
authors.lastname: Minina
authors.forename: O L
authors.initials: OL
authors.lastname: Myakotina
authors.forename: T A
authors.initials: TA
authors.lastname: Mamikonova
authors.forename: L M
authors.initials: LM
authors.lastname: Tsofina
authors.forename: N E
authors.initials: NE
authors.lastname: Shklovski-Kordi
mesh_terms: D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects; D000242:Cyclic AMP / Q000494:pharmacology*; D004553:Electric Conductivity; D004734:Energy Metabolism; D006372:Helix, Snails; D066298:In Vitro Techniques; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009441:Neurilemma / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D014044:Tolbutamide / Q000494:pharmacology; D014475:Uncoupling Agents / Q000494:pharmacology
chemical_list: D008869:Microtubule-Associated Proteins; D014475:Uncoupling Agents; D003994:Bucladesine; D014044:Tolbutamide; D012964:Sodium; D000242:Cyclic AMP; D011494:Protein Kinases; D011188:Potassium