Human pharmacology of 1S and 1R enantiomers of delta-3-tetrahydrocannabinol.
Two enantiomers (1S and 1R) of delta-3-tetrahydrocannabinol were assayed in man for psychoactivity. The 1S enantiomer had definite psychic actions, qualitatively similar to those of delta-1-tetrahydrocannabinol, but quantitatively less potent (1:3 to 1:6). Adding the two enantiomers together did not increase the effect, confirming that activity was solely in the one enantiomer and that there was no interaction between them.
Hollister
L E
LE
Gillespie
H K
HK
Mechoulam
R
R
Srebnik
M
M
D000328:Adult; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000008:administration & dosage / Q000494:pharmacology*; D004644:Emotions / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011674:Pulse / Q000187:drug effects; D013237:Stereoisomerism
D013759:Dronabinol