Cushing's disease and craniopharyngioma.
A 14-year old girl presented with growth failure and Cushing's disease. Histological examination confirmed a craniopharyngioma but failed to show that the tumour secreted adrenocorticotrophic hormone. We suggest that her Cushing's disease was caused by hypothalamic dysfunction associated with increased corticotrophin-releasing hormone secretion, secondary to the craniopharyngioma.
Ackland
F M
FM
Department of Growth and Development, Institute of Child Health, London.
Stanhope
R
R
Preece
M A
MA
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D003397:Craniopharyngioma / Q000150:complications* / Q000378:metabolism; D003480:Cushing Syndrome / Q000209:etiology*; D005260:Female; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D010911:Pituitary Neoplasms / Q000150:complications* / Q000378:metabolism
D000324:Adrenocorticotropic Hormone