Inhibition of non-adrenergic transmission in the rat vas deferens by prazosin.
Isolated preparations of rat vas deferens were induced to contract by neurogenic and non-neurogenic stimuli, and the effect of prazosin on these contractions was investigated. Prazosin (24 microM) exerted a profound inhibitory effect on neurogenic contractions and had no significant effect on non-neurogenic contractions. These experiments indicate that prazosin is capable of interacting with the neurotransmission processes in the vas deferens to produce inhibition of transmission.
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Department of Pharmacological Sciences, Medical School, University of Newcastle upon Tyne, U.K.
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D000818:Animals; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D011189:Potassium Chloride / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000187:drug effects*; D014649:Vas Deferens / Q000187:drug effects / Q000294:innervation
D011189:Potassium Chloride; D011224:Prazosin