Evidence for gamma-aminobutyric acid receptor-mediated modulation of the aortic baroreceptor reflex in the nucleus tractus solitarii of the rat.
Microinjections of the gamma-aminobutyric acid (GABA) receptor antagonist bicuculline into the medial area of the nucleus tractus solitarii of the rat enhanced the depressor and bradycardiac responses to aortic nerve stimulation whereas the glycine receptor antagonist strychnine did not affect them. The GABA receptor agonist muscimol and the GABA uptake inhibitor nipecotic acid reduced the responses to aortic nerve stimulation. These results provide evidence suggesting GABA receptor-mediated modulation of the aortic baroreceptor reflex in the nucleus tractus solitarii of the rat.
Kubo
T
T
Department of Pharmacology, Yokohama City University School of Medicine, Japan.
Kihara
M
M
D000818:Animals; D001011:Aorta / Q000294:innervation*; D001640:Bicuculline / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004558:Electric Stimulation; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D011311:Pressoreceptors / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000502:physiology*; D012018:Reflex / Q000502:physiology*
D011963:Receptors, GABA-A; D001640:Bicuculline