[Effect of physical load and brief monotherapy with obsidan on the characteristics of beta 2-adrenoreceptors of intact lymphocytes in patients with hypertension].
Lymphocytes beta 2-receptor density (LBRD) was studied by binding with 125ICYP in 18 male patients with mild/moderate essential hypertension (EH) before and after propranolol monotherapy. In 5 of these patients LBRD was determined before and after dynamic exercise also. Propranolol therapy evoked different changes in LBRD in patients with EH. According to these results, all the patients were divided into 2 groups: the patients who respond to propranolol administration by an increase in the LBRD were attributed to the 1 group. If the LBRD decreased after propranolol, the patients were attributed to the 2 group. Propranolol had pronounced hypotensive effect in the 2 group and no hypotensive effect in the 1 group. Heart rate was significantly higher initially and decreased significantly more after treatment in the 2 group. In this group initial values of LBRD were significantly higher than in the 1 group. Exercise produced different changes in LBRD, which correlated with the changes produced by propranolol treatment. The positive correlations were found between LBRD and left ventricular myocardial mass and interventricular septum thickness. The data obtained indicate that LBRD is regulated in a qualitatively different manner in the two groups of patients with EH which appears to be related to baseline renin or perhaps catecholamine levels.
Parfenova
E V
EV
Nauman
E
E
Korichneva
I L
IL
Suvorov
Iu I
IuI
Aripova
N A
NA
D000328:Adult; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008214:Lymphocytes / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D011433:Propranolol / Q000008:administration & dosage*; D011943:Receptors, Adrenergic, beta / Q000032:analysis* / Q000187:drug effects
D011943:Receptors, Adrenergic, beta; D011433:Propranolol
Vliianie fizicheskoĭ nagruzki i korotkogo kursa monoterapii obzidanom na kharakteristiki beta 2-adrenoretseptorov intaktnykh limfotsitov bol'nykh gipertonicheskoĭ bolezn'iu.