title: Acute effects of oral phosphate-salt ingestion on serum phosphorus, serum ionized calcium, and parathyroid hormone in young adults.
abstract: We studied the effect of acute oral phosphate loading on parathyroid hormone (PTH) secretion and action. Eighteen adults were studied before and after ingestion of 1 g elemental phosphorus as neutral sodium-potassium phosphate in grape juice or in water and 1.7 g NaCl in juice was used as a control. Five subjects were studied after ingesting 1.5 g P in juice. Blood was drawn every 15 min from -45 to +300 min for measurement of serum ionized calcium (Ca++), P, total Ca, creatinine, and immunoreactive PTH (iPTH); urine was collected hourly. Serum P declined after NaCl ingestion but rose significantly after ingestion of 1 g P in juice or in water. There were no significant changes in serum Ca++, iPTH, or urinary cyclic AMP excretion. Acute ingestion of 1-1.5 g P, which exceeds the P content of a normal meal, does not decrease serum Ca++ or increase iPTH secretion or renal action in normal adults.
authors.affiliation: Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55902.
authors.forename: M S
authors.initials: MS
authors.lastname: Calvo
authors.forename: H
authors.initials: H
authors.lastname: Heath
mesh_terms: D000328:Adult; D002118:Calcium / Q000097:blood* / Q000652:urine; D002413:Cations, Divalent; D003404:Creatinine / Q000097:blood; D000242:Cyclic AMP / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D010758:Phosphorus / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology* / Q000652:urine; D012964:Sodium / Q000652:urine; D012965:Sodium Chloride / Q000494:pharmacology
chemical_list: D002413:Cations, Divalent; D010281:Parathyroid Hormone; D010758:Phosphorus; D012965:Sodium Chloride; D012964:Sodium; D003404:Creatinine; D000242:Cyclic AMP; D002118:Calcium