title: Up-regulatory effect of triphasic oral contraceptive on platelet 3H-imipramine binding sites.
abstract: Triphasic oral contraceptive (Logynon) induced a significant increase (36%) in the maximal binding capacity of platelet membranes for [3H]imipramine. The increase was achieved in the second Logynon cycle as compared to pretreatment and first Logynon cycle binding values. The pill contains a combination of ethinyl estradiol and levonorgestrel, and it is as yet unclear which of the two hormones is responsible for the up-regulatory effect. The increase in the density of platelet imipramine binding sites may reflect a similar alteration in brain. The increase in imipramine binding did not correlate with alteration in mood as assessed by Beck Depression Inventory scores.
authors.affiliation: Geha Psychiatric Hospital, Belinson Medical Center, Tel-Aviv, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Weizman
authors.forename: H
authors.initials: H
authors.lastname: Morgenstern
authors.forename: B
authors.initials: B
authors.lastname: Kaplan
authors.forename: Z
authors.initials: Z
authors.lastname: Amiri
authors.forename: S
authors.initials: S
authors.lastname: Tyano
authors.forename: Y
authors.initials: Y
authors.lastname: Ovadia
authors.forename: M
authors.initials: M
authors.lastname: Rehavi
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002352:Carrier Proteins; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage*; D003866:Depressive Disorder / Q000097:blood; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood*; D009644:Norgestrel / Q000008:administration & dosage*; D011581:Psychological Tests; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000187:drug effects* / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D003278:Contraceptives, Oral, Hormonal; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D009644:Norgestrel; D004997:Ethinyl Estradiol; D019304:Ethinyl Estradiol-Norgestrel Combination; D007099:Imipramine