Synthesis, spectroscopic, and cytotoxicity studies of some diamine and diimine platinum(II) complexes of diethyldithiocarbamate.
Four new water soluble complexes of the formula [Pt(DA)(DDTC)]NO3 (where DA is 2,2'-bipyridine, 1,10-phenanthroline, 1,2-diaminopropane, or 1,2-diaminocyclohexane, and DDTC is diethyldithiocarbamate anion) have been synthesized by reaction of platinum-diamine/diimine diaqua complex with sodium diethyldithiocarbamate in molar ratio of 1:1. These complexes have been characterized by the chemical analysis, and ultraviolet-visible, infra-red and 1H NMR spectroscopy. The infrared and 1H NMR spectral studies of these complexes have ascertained the modes of binding of diamine/diimine and diethyldithiocarbamate to platinum. The molar conductance values of these platinum complexes in conductivity water suggest them to be 1:1 electrolytes. These four complexes and two other complexes containing ethylenediamine and 1,3-diaminopropane ligands have been tested against P-388 lymphocytic leukemic cells. Out of them only 2,2'-bipyridine and 1,10-phenanthroline complexes show 1.D.50 values less than cisplatin.
Jain
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N
Department of Chemistry, Indian Institute of Technology, Powai, Bombay.
Srivastava
T S
TS
Satyamoorthy
K
K
Chitnis
M P
MP
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003959:Diamines / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D004050:Ditiocarb / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D007097:Imines / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D007202:Indicators and Reagents; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D003959:Diamines; D007097:Imines; D007202:Indicators and Reagents; D009943:Organophosphorus Compounds; D004050:Ditiocarb