title: Studies on the mechanism of inhibition of chemotactic tripeptide stimulated human neutrophil polymorphonuclear leucocyte superoxide production by chloroquine and hydroxychloroquine.
abstract: The effect of chloroquine and hydroxychloroquine on neutrophil superoxide release stimulated by the chemotactic tripeptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) was examined. Both drugs caused time and dose dependent inhibition of superoxide release but had no effect on equilibrium binding of [3H]FMLP to its receptor. Preliminary experiments suggest that these drugs may exert their inhibitory effect on superoxide release by inhibiting the FMLP stimulated hydrolysis of phosphoinositides.
authors.affiliation: Queen Elizabeth Hospital Rheumatology Unit, Woodville, South Australia.
authors.forename: N P
authors.initials: NP
authors.lastname: Hurst
authors.forename: J K
authors.initials: JK
authors.lastname: French
authors.forename: L
authors.initials: L
authors.lastname: Gorjatschko
authors.forename: W H
authors.initials: WH
authors.lastname: Betts
mesh_terms: D002634:Chemotaxis, Leukocyte; D002738:Chloroquine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006886:Hydroxychloroquine / Q000494:pharmacology*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000378:metabolism / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D013481:Superoxides / Q000493:pharmacokinetics*
chemical_list: D013481:Superoxides; D006886:Hydroxychloroquine; D009240:N-Formylmethionine Leucyl-Phenylalanine; D002738:Chloroquine