Stimulation of brain Na,K-ATPase by norepinephrine but not taurine.
The effect of taurine on rat and hamster brain Na,K-ATPase was examined and compared to norepinephrine (NE) stimulation of the enzyme. Although NE stimulation of microsomal Na,K-ATPase was observed in the presence of the cell cytosolic fraction, taurine was without effect in the presence and absence of this fraction. Taurine also failed to modulate pubescent and mature hamster brain Na,K-ATPase. Presence or absence of ion chelators did not change taurine's effect. These results are discussed in relation to previous reports of taurine and catecholamine stimulation of Na,K-ATPase.
Chapman
G E
GE
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario.
Greenwood
C E
CE
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D006224:Cricetinae; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013654:Taurine / Q000494:pharmacology*
D013654:Taurine; D000254:Sodium-Potassium-Exchanging ATPase; D009638:Norepinephrine