Successful outcome of severe aplastic anemia following Epstein-Barr virus infection.
Severe aplastic anemia has been reported in children following Epstein-Barr virus (EBV) infection. The pathophysiology of disease is not known, but an immunologic mechanism is suspected because of the rapid response to steroids. A patient with severe aplastic anemia following EBV infection experienced bone marrow recovery after treatment with high-dose prednisone. After reviewing the literature it is concluded that steroid therapy is indicated in this select group of patients.
Grishaber
J E
JE
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
McClain
K L
KL
Mahoney
D H
DH
Fernbach
D J
DJ
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human; D006801:Humans; D013997:Time Factors
D000305:Adrenal Cortex Hormones