[Thrombocyte function in unstable angina pectoris].
In a prospective study, platelet aggregation in platelet-rich plasma after ADP stimulation (0.5, 1.0 and 10 mumol/l) and collagen (1 and 5 micrograms/ml) was measured in 36 patients with coronary heart disease, 18 with angina at rest during the eight hours preceding the time of blood sampling, and 18 patients with stable, exercise-dependent angina, matched for age and sex. In addition, c-AMP was determined, before and (as a measure of platelet adenylate cyclase activity) after stimulation of this enzyme by prostaglandin E1 (10 mumol/l for 30 sec). There were no differences between all the tested ADP and collagen concentrations with regard to platelet aggregation. c-AMP levels were also similar. Thus, in patients with unstable angina there was no evidence for generalized hyperaggregation of platelets in comparison with control subjects who had stable exercise-dependent angina.
Terres
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Abteilung für Kardiologie, Universitätskrankenhaus Eppendorf, Hamburg.
Hamm
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CW
Kupper
W
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Bleifeld
W
W
D000244:Adenosine Diphosphate; D000262:Adenylyl Cyclases / Q000097:blood; D000527:Alprostadil; D000787:Angina Pectoris / Q000097:blood*; D000789:Angina, Unstable / Q000097:blood*; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D003094:Collagen; D003327:Coronary Disease / Q000097:blood; D000242:Cyclic AMP / Q000097:blood; D006801:Humans; D007223:Infant; D010974:Platelet Aggregation / Q000187:drug effects; D011446:Prospective Studies
D000244:Adenosine Diphosphate; D003094:Collagen; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D000527:Alprostadil
Thrombozytenfunktion bei instabiler Angina pectoris.