The effect of hydroxyl radical scavenging on acute axial-random skin flap survival.
Dimethyl thiourea (DMTU), a known hydroxyl radical scavenger, was tested for its ability to improve survival in acute island skin flaps. Rats receiving 500 mg/kg DMTU 1 hour after flap elevation showed a 23.5% improved survival over saline controls. The role of the hydroxyl radical in ischemia/reperfusion injury, and its proposed mechanism, is discussed.
Hayden
R E
RE
Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110.
Paniello
R C
RC
Yeung
C S
CS
Bello
S L
SL
D000818:Animals; D006085:Graft Survival / Q000187:drug effects*; D006878:Hydroxides / Q000378:metabolism*; D017665:Hydroxyl Radical; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000098:blood supply / Q000378:metabolism; D013524:Surgical Flaps; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology
D006878:Hydroxides; D017665:Hydroxyl Radical; C038983:1,3-dimethylthiourea; D013890:Thiourea