Neoplastic transformation of the rat visceral yolk sac by polyoma virus.
The transforming activity of polyoma virus was verified in vitro in organ cultures of 12-day old rat visceral yolk sacs and embryos. Organ cultures of 18-day old fetal organs were also included. The transforming capacity of the virus was found to be restricted to the endothelial cells of the rat visceral yolk sac. The neoplastic endothelial cells are readily transplantable and possess the polyoma tumor-specific transplantation antigens (TSTA).
Lu
Y L
YL
University of Leuven, Rega Institute, Belgium.
Sobis
H
H
Vandeputte
M
M
D000818:Animals; D000941:Antigens / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002472:Cell Transformation, Viral; D004727:Endothelium / Q000473:pathology; D005167:Factor VII / Q000032:analysis / Q000276:immunology; D005260:Female; D006391:Hemangioma / Q000209:etiology / Q000276:immunology; D006649:Histocompatibility Antigens / Q000032:analysis; D009368:Neoplasm Transplantation; D009924:Organ Culture Techniques; D011120:Polyomavirus / Q000472:pathogenicity*; D051381:Rats; D011919:Rats, Inbred Strains; D015017:Yolk Sac / Q000473:pathology*
D000941:Antigens; D000951:Antigens, Neoplasm; D006649:Histocompatibility Antigens; C031500:factor VII related antigen; C029237:tumor-associated transplantation antigen; D005167:Factor VII