[Isolation of viruses in the cerebrospinal fluid in a case of acute varicella meningo-encephalitis].
The authors report a case of severe, life-threatening, meningo-encephalitis occurring in a young nonimmunodepressed adult with varicella. The demonstration of a cytopathogenetic effect of his cerebrospinal fluid and of immunoglobulins M specific to the varicella-zoster virus was in favour of an acute, directly viral-dependent encephalitis rather than an immune-mediated leucoencephalitis, as used to be commonly admitted. This is an incitement to use acyclovir in such cases, the effect of which contributes to reinforce this pathogenic hypothesis.
Auzanneau
G
G
Chagnon
A
A
Morillon
M
M
Verdier
M
M
de Jaureguiberry
J P
JP
D000328:Adult; D002644:Chickenpox / Q000150:complications; D014645:Herpesvirus 3, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid* / Q000209:etiology / Q000382:microbiology
Isolement du virus dans le liquide céphalo-rachidien dans un cas de méningo-encéphalite aiguë de la varicelle.