Absence of missense mutations in activated c-myc genes in avian leukosis virus-induced B-cell lymphomas.
We have determined the nucleotide sequences of two independent DNA clones which contained the activated c-myc genes from avian leukosis virus-induced B-cell lymphomas. Neither of these c-myc genes contained missense mutations. This strongly supports the notion that the c-myc proto-oncogene in avian leukosis virus-induced B-cell lymphomas can be oncogenically activated by altered expression of the gene without a change in the primary structure of the gene product.
Hahn
M
M
Graduate Program in Molecular Biology, Sloan-Kettering Institute for Cancer Research, New York, New York.
Hayward
W S
WS
D000818:Animals; D001353:Avian Leukosis; D001354:Avian Leukosis Virus; D001402:B-Lymphocytes; D001483:Base Sequence; D001717:Birds; D003001:Cloning, Molecular; D008223:Lymphoma / Q000032:analysis* / Q000382:microbiology; D008969:Molecular Sequence Data; D009154:Mutation; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc; D011519:Proto-Oncogenes
D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc