[Decrease in the cytogenetic effect of adriblastin and pharmorubicin with the experimental use of tularemia vaccine].
Immunization of Wistar rats with tularemic vaccine has been studied for its influence on the cytogenetic effect of adryblastine and pharmorubicyn. It is shown that the number of aberrant metaphases considerably decreases in the myelocaryocytes of vaccinated rats. Antimutagenic effect is induced by the influence of tularemic vaccine on the metabolic activation processes of antibiotics and, possibly, by an increase of the activity of antioxidative enzymes in the rat organism.
Nersesian
A K
AK
Zil'fian
V N
VN
Kumkumadzhian
V A
VA
D000818:Animals; D001428:Bacterial Vaccines / Q000494:pharmacology*; D002869:Chromosome Aberrations; D004317:Doxorubicin / Q000633:toxicity*; D015251:Epirubicin / Q000633:toxicity*; D005604:Francisella tularensis / Q000276:immunology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001428:Bacterial Vaccines; D015251:Epirubicin; D004317:Doxorubicin
Snizhenie tsitogeneticheskogo deĭstviia adriblastina i farmorubitsinas pomoshch'iu tuliaremiĭnoĭ vaktsiny v éksperimente.