title: Edinger-Westphal nucleus: cells that project to spinal cord contain corticotropin-releasing factor.
abstract: Combined retrograde transport and immunocytochemical methods were used to determine whether neurons in the Edinger-Westphal complex (EW) that project to the spinal cord also demonstrate corticotropin-releasing factor-like immunoreactivity (CRF-LI). Large injections of horseradish peroxidase (HRP) into cervical spinal cord retrogradely labeled cells throughout the extent of the EW complex. Most retrogradely labeled EW neurons also exhibited CRF-LI, evidence that EW is the origin of a direct CRF-containing pathway which links the rostral mesencephalon with spinal cord.
authors.affiliation: Neurology Service, Massachusetts General Hospital, Boston 02114.
authors.forename: R Y
authors.initials: RY
authors.lastname: Chung
authors.forename: P
authors.initials: P
authors.lastname: Mason
authors.forename: A
authors.initials: A
authors.lastname: Strassman
authors.forename: R
authors.initials: R
authors.lastname: Maciewicz
mesh_terms: D000818:Animals; D002415:Cats; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D006735:Horseradish Peroxidase; D007150:Immunohistochemistry; D009474:Neurons / Q000378:metabolism; D009802:Oculomotor Nerve / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*; D009435:Synaptic Transmission
chemical_list: D003346:Corticotropin-Releasing Hormone; D006735:Horseradish Peroxidase