title: Toxicity trial of prophylactic 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine (ganciclovir) after marrow transplantation in dogs.
abstract: The effects of 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine, or ganciclovir, administered during the immediate posttransplant period to dogs given total-body irradiation and autologous marrow transplants were studied. Doses of ganciclovir of 3.0 mg/kg (body weight) per day were well tolerated without detectable delay in hematopoietic recovery, whereas doses of 5.0 mg/kg per day were associated with delayed platelet recovery.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
authors.forename: F R
authors.initials: FR
authors.lastname: Appelbaum
authors.forename: J D
authors.initials: JD
authors.lastname: Meyers
authors.forename: H J
authors.initials: HJ
authors.lastname: Deeg
authors.forename: T
authors.initials: T
authors.lastname: Graham
authors.forename: F
authors.initials: F
authors.lastname: Schuening
authors.forename: R
authors.initials: R
authors.lastname: Storb
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use / Q000633:toxicity*; D016026:Bone Marrow Transplantation; D003524:Cyclosporins / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000517:prevention & control*; D004285:Dogs; D015774:Ganciclovir; D007165:Immunosuppression Therapy; D010976:Platelet Count / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D003524:Cyclosporins; D015774:Ganciclovir; D000212:Acyclovir