[The effect of malondialdehyde in the diet of pregnant and lactating female rats on the lipid peroxidation process and physical development of newborn rats].
Intake of malonic dialdehyde (MDA) with drinking water by pregnant and lactating rats did not result in MDA accumulation in their body or in significant shifts in the system lipid peroxidation--antioxidant activity (LPO-AOA). However, two litters of progeny from rats, that ingested MDA, were found to be nonviable with drastically diminished mass of their brain and significant shifts in the system LPO-AOA. High content of MDA, sharply reduced concentration of lipid hydroperoxides, and lowered AOA were detected in the brain tissue, red blood cells and blood plasma of 15-day rats whose mothers ingested MDA during pregnancy and lactation. The lowered activity of the system LPO-AOA in the test young rats was attended by retardation of their physical development.
Bankova
V V
VV
Simutenko
L V
LV
Barsegian
G G
GG
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D000975:Antioxidants; D001921:Brain / Q000378:metabolism; D004032:Diet; D004912:Erythrocytes / Q000032:analysis; D005260:Female; D007774:Lactation; D015227:Lipid Peroxidation / Q000187:drug effects*; D008314:Malonates / Q000494:pharmacology*; D008315:Malondialdehyde / Q000378:metabolism / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010084:Oxidation-Reduction; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
D000975:Antioxidants; D008314:Malonates; D008315:Malondialdehyde
Vliianie malonovogo dial'degida v ratsione beremennykh i kormiashchikhkrys-samok na protsess perekisnogo okisleniia lipidov i fizicheskoe razvitie novorozhdennykh krysiat.