[Ultrastructure of adenohypophyseal cells of white rats subjected to the effect of a benzodiazepine in chronic form].
The ultrastructure of the pars anterior (adenohypophysis), treated with diazepam (2.5 mg/Kg) has been studied by thin sections and electron microscopy. The structure of Thyrotrophs, Corticotrophs, Gonadotrophs, and Mammotrophs cells were described. Ultrastructural modifications were not observed. It is concluded that the chronic treatment with diazepam did not produce any visible ultrastructural effects in the secretory cells of the adeno hypophysis; maybe because the diazepam has a short life time and due to the small effect of the diazepam metabolites in this species.
Sancho Ugalde
H
H
Departamento de Fisiología, Escuela de Medicina, Universidad de Costa Rica.
Ureña Calderón
F
F
D000818:Animals; D000242:Cyclic AMP / Q000096:biosynthesis; D003563:Cyclic CMP / Q000096:biosynthesis; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000648:ultrastructure*; D010908:Pituitary Hormones, Anterior / Q000378:metabolism; D051381:Rats
D010908:Pituitary Hormones, Anterior; D003563:Cyclic CMP; D000242:Cyclic AMP; D003975:Diazepam
Ultraestructura de las células adenohipofisiarias de la rata blanca sometida al efecto de una benzodiazepina en forma crónica.