title: A retrovirus carrying the polyomavirus middle T gene induces acute thrombocythemic myeloproliferative disease in mice.
abstract: Mice inoculated with an artificially constructed retrovirus carrying the middle T gene of polyomavirus develop acute myeloproliferative disease with severe thrombotic and hemorrhagic disorder and impaired platelet function. The megakaryocytic lineage appears to be a target for polyoma-murine leukemia virus infection and middle T gene expression. This newly described disease represents a unique model system for studying disorders of the megakaryocytic lineage.
authors.affiliation: Centro di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Fusco
authors.forename: G
authors.initials: G
authors.lastname: Portella
authors.forename: M
authors.initials: M
authors.lastname: Grieco
authors.forename: G
authors.initials: G
authors.lastname: Tajana
authors.forename: G
authors.initials: G
authors.lastname: Di Minno
authors.forename: N
authors.initials: N
authors.lastname: Polli
authors.forename: A
authors.initials: A
authors.lastname: Pinto
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000957:Antigens, Viral, Tumor / Q000235:genetics*; D000001:Calcimycin / Q000494:pharmacology; D004274:DNA, Recombinant; D009052:Leukemia Virus, Murine / Q000235:genetics / Q000472:pathogenicity*; D051379:Mice; D009196:Myeloproliferative Disorders / Q000382:microbiology* / Q000473:pathology; D010974:Platelet Aggregation; D011120:Polyomavirus / Q000472:pathogenicity*; D013920:Thrombocythemia, Essential / Q000382:microbiology* / Q000473:pathology
chemical_list: D000957:Antigens, Viral, Tumor; D004274:DNA, Recombinant; D000001:Calcimycin; D000255:Adenosine Triphosphate