Studies of rhinovirus resistant to an antiviral chalcone.
During studies of the antiviral activity of chalcone Ro-09-0410 on human rhinovirus type 9 (RV9) chalcone-resistant strains of RV9 were isolated and appeared with a frequency of about 10(-5) in chalcone sensitive stock. Chalcone-dependent viruses were found after further passage. Some characteristics of the resistant viruses were studied and compared with those of the wild type virus; a number of differences were detected. They produced smaller plaques and grew to lower titre; they were no longer protected by chalcone from inactivation by heat and low pH. The event responsible for drug dependence apparently took place after that responsible for drug resistance. Drug-resistant viruses were still sensitive to dichloroflavan and enviroxime.
Ahmad
A L
AL
MRC Common Cold Unit, Harvard Hospital, Salisbury, Wiltshire, U.K.
Dowsett
A B
AB
Tyrrell
D A
DA
D000998:Antiviral Agents / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives / Q000494:pharmacology*; D047188:Chalcones; D003470:Culture Media; D004352:Drug Resistance, Microbial; D006367:HeLa Cells; D006358:Hot Temperature; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008854:Microscopy, Electron; D009154:Mutation; D011427:Propiophenones / Q000494:pharmacology*; D012229:Rhinovirus / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development / Q000648:ultrastructure
D000998:Antiviral Agents; D047188:Chalcones; D003470:Culture Media; D011427:Propiophenones; D002599:Chalcone; C036425:Ro 09-0410