title: Atriopeptin 2 is hydrolysed by cardiac but not pulmonary isozyme of angiotensin-converting enzyme.
abstract: Hydrolysis of Bz-Gly-Ser-Phe-Arg, C-terminal fragment of atriopeptin 2, by human cardiac angiotensin-converting enzyme has been studied. The KM for the reaction was 10(-4) M. The effect of concentration of NaCl on activity of cardiac angiotensin-converting enzyme has been determined, which allowed to regard Bz-Gly-Ser-Phe-Arg as bradykinin-like substrates. It was demonstrated that cardiac, but not pulmonary isozyme of angiotensin-converting enzyme specifically hydrolyses atriopeptin 2.
authors.affiliation: Institute of Experimental Cardiology, CRC AMS USSR, Moscow.
authors.forename: I Y
authors.initials: IY
authors.lastname: Sakharov
authors.forename: E A
authors.initials: EA
authors.lastname: Dukhanina
authors.forename: A S
authors.initials: AS
authors.lastname: Molokoedov
authors.forename: S M
authors.initials: SM
authors.lastname: Danilov
authors.forename: M V
authors.initials: MV
authors.lastname: Ovchinnikov
authors.forename: Z D
authors.initials: ZD
authors.lastname: Bespalova
authors.forename: M I
authors.initials: MI
authors.lastname: Titov
mesh_terms: D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D006801:Humans; D006868:Hydrolysis; D007527:Isoenzymes / Q000378:metabolism*; D008168:Lung / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D009928:Organ Specificity; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D009320:Atrial Natriuretic Factor; D007703:Peptidyl-Dipeptidase A