title: Structure-activity relationships of peptide T-related pentapeptides.
abstract: Fifteen pentapeptide analogs of C-terminal fragment of peptide T, H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH, were prepared and tested for human monocyte chemotaxis. Structure-activity studies suggest that the potent chemotactic activity of H-Thr-Thr-Asn-Tyr-Thr-OH is mediated through the polar properties of the C-terminal carboxyl group and Thr side chains at the critical positions 5 and 8, while the hydroxyl group of N-terminal Thr and its free amino function are not essential requirements for CD4 receptor interactions.
authors.affiliation: Department of Pharmaceutical Sciences, University of Ferrara, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Marastoni
authors.forename: S
authors.initials: S
authors.lastname: Salvadori
authors.forename: G
authors.initials: G
authors.lastname: Balboni
authors.forename: S
authors.initials: S
authors.lastname: Spisani
authors.forename: R
authors.initials: R
authors.lastname: Gavioli
authors.forename: S
authors.initials: S
authors.lastname: Traniello
authors.forename: R
authors.initials: R
authors.lastname: Tomatis
mesh_terms: D015704:CD4 Antigens / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D002633:Chemotaxis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes / Q000187:drug effects; D015717:Peptide T / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D015704:CD4 Antigens; D015717:Peptide T