Prostaglandins and leukotrienes in the perinatal period.
Arachidonic acid is the precursor of many physiologically active substances. One such group, the prostaglandins, is involved in regulation of the ductus arteriosus, the perinatal pulmonary circulation, and uterine function. Administration of these substances or inhibition of their production or effect has therapeutic benefit in many different circumstances. Another group, the leukotrienes, also appears to be involved in regulation of the perinatal pulmonary circulation; pharmacologic manipulation of these has not yet been tried.
Heymann
M A
MA
Cardiovascular Research Institute, University of California, San Francisco.
D004373:Ductus Arteriosus / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006330:Heart Defects, Congenital / Q000188:drug therapy; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007231:Infant, Newborn; D007975:Leukotriene B4 / Q000502:physiology; D007752:Obstetric Labor, Premature / Q000188:drug therapy; D011247:Pregnancy; D011453:Prostaglandins / Q000009:adverse effects / Q000494:pharmacology / Q000502:physiology; D013189:SRS-A / Q000502:physiology; D014590:Uterine Contraction / Q000187:drug effects
D011453:Prostaglandins; D013189:SRS-A; D007975:Leukotriene B4; D007213:Indomethacin