Comparison between the allelic frequency distribution of the Ha-ras 1 locus in normal individuals and patients with lymphoma, breast, and ovarian cancer.
Analysis of 426 alleles of the human Ha-ras 1 locus in DNA samples of cancer patients and controls reveals no obvious association between specific restriction fragments and a genetic predisposition to malignancy. However, differences in the allele distribution in leukocyte and tumour DNAs of cancer patients may be related to an involvement of the Ha-ras 1 gene in tumorigenesis.
Corell
B
B
Institut für Humangenetik der Universität, Göttingen, Federal Republic of Germany.
Zoll
B
B
D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics*; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004262:DNA Restriction Enzymes; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005787:Gene Frequency; D011905:Genes, ras; D006801:Humans; D007962:Leukocytes / Q000166:cytology; D008223:Lymphoma / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010051:Ovarian Neoplasms / Q000235:genetics*; D012016:Reference Values
D004273:DNA, Neoplasm; D004247:DNA; D004262:DNA Restriction Enzymes