title: [Ischemic brain infarct: combined determination of regional cerebral blood flow and volume by SPECT].
abstract: A combined measurement of regional cerebral blood flow (r CBF) and volume (r CBV) by SPECT was performed in 15 patients with ischaemic cerebral infarction. For measurement of r CBF 99mTc-HMPAO was used, and for r CBV 99mTc-labelled red blood cells. Patients with acute or subacute cerebral infarction (n = 10) showed elevation of r CBV whereas r CBF was either reduced or elevated. Patients with chronic cerebral infarction (n = 5) showed reduction of both r CBF and r CBV. The combined measurement of both r CBF and r CBV by SPECT allows imaging and semiquantitative evaluation of haemodynamic changes in ischaemic cerebral infarction at various stages. The resulting data may be helpful in describing the pathophysiologic compensatory mechanisms.
authors.affiliation: Strahlenklinik und Poliklinik, Universitätsklinikum Rudolf Virchow, Standort Charlottenburg, Freie Universität Berlin.
authors.forename: M
authors.initials: M
authors.lastname: Cordes
authors.forename: H
authors.initials: H
authors.lastname: Henkes
authors.forename: A
authors.initials: A
authors.lastname: Scholz
authors.forename: H
authors.initials: H
authors.lastname: Eichstädt
authors.forename: R
authors.initials: R
authors.lastname: Felix
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001810:Blood Volume; D001811:Blood Volume Determination / Q000379:methods; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002544:Cerebral Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D006801:Humans; D008875:Middle Aged; D009942:Organometallic Compounds; D010091:Oximes; D013670:Sodium Pertechnetate Tc 99m; D013667:Technetium; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed
chemical_list: D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D013667:Technetium; D013670:Sodium Pertechnetate Tc 99m
vernacular_title: Ischämische Hirninfarkte: Die kombinierte Bestimmung von regionalem zerebralen Blutfluss und Volumen mittels SPECT.