Double-blind crossover trial to compare the activity of nedocromil sodium and placebo in antigen challenge.
In a double-blind crossover placebo controlled study, the inhibitory effects of three different doses of nedocromil sodium on the immediate bronchoconstrictor response to antigen challenge were compared with a placebo. All the test treatments were inhaled three hours before challenge. Four asthmatic patients took part in the study and the test treatments were taken in a randomized order. All three doses of nedocromil sodium significantly reduced the bronchoconstrictor response and protected the patients against antigen challenge, compared with placebo. The highest dose of 2 mg was the most effective dose. All test doses of nedocromil sodium were safe and well tolerated by the patients.
Bonifazi
F
F
Allergy Respiratory Unit, Regional General Hospital, Rome, Italy.
Antonicelli
L
L
Pieretti
C
C
Piunti
E
E
Rossini
R
R
Patalano
F
F
Ruggieri
F
F
D000280:Administration, Inhalation; D000328:Adult; D001985:Bronchial Provocation Tests; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D017835:Nedocromil; D011804:Quinolines / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation
D011804:Quinolines; D017835:Nedocromil