Pharmacokinetics of propofol during continuous infusion for pediatric anesthesia.
The blood concentrations of propofol have been examined during anesthesia by continuous infusion of 12 mg/hg/hr. A bolus dose of 3 mg/kg body weight propofol was used to induce anesthesia. The mean concentrations at apparent steady state were in the range of 4.3 to 5.6 micrograms/ml during the infusion. The mean total body clearance, derived from the apparent steady state concentrations in the blood, was 0.0394 litres/kg/minute. The mean propofol blood concentration at awakening was found to be 2.3 micrograms/ml.
Vandermeersch
E
E
Department of Anesthesiology, Katholieke Universiteit Leuven, U.A. Gasthuisberg, Belgium.
Van Hemelrijck
J
J
Byttebier
G
G
Van Aken
H
H
D000771:Anesthesia, Intravenous; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D015742:Propofol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D015742:Propofol