[Neuromodulator mechanism of the inhibitory effect of deoxycorticosterone on the aggressive-defensive behavior of the rat].
DOCA (0.3 mg/kg i.p.) inhibited the shock-induced aggression in male rats. This behavioural reaction was also inhibited by activation of brain beta-adrenergic and nicotinic receptors. The inhibitory hormone effect was potentiated to a considerable extent (p less than 0.05-0.001) by central beta-adrenergic stimulation but was blocked by beta-antagonist administration. However, it was independent of facilitatory and inhibitory actions on the brain nicotinic receptors. It is concluded that the DOCA inhibitory effect on the shock-induced defensive fighting involved the facilitation of the brain beta-adrenergic receptor activation.
Sever'ianova
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D000374:Aggression / Q000187:drug effects*; D000378:Agonistic Behavior / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D003900:Desoxycorticosterone / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D007545:Isoproterenol / Q000008:administration & dosage; D008297:Male; D009538:Nicotine / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D011978:Receptors, Nicotinic / Q000187:drug effects*
D011943:Receptors, Adrenergic, beta; D011978:Receptors, Nicotinic; D003900:Desoxycorticosterone; D009538:Nicotine; D007545:Isoproterenol
Neĭromoduliatornyĭ mekhanizm tormoznogo vliianiia dezoksikortikosterona na agressivno-oboronitel'noe povedenie krys.