Interferon-gamma induces class II MHC antigens on RINm5F cells.
The ability of recombinant interferon-gamma (rIFN-gamma) to induce major histocompatibility complex (MHC) antigen expression in the rat insulinoma cell line RINm5F was investigated. The cells were stained with monoclonal antibodies specific for rat class I and class II MHC antigens. RINm5F cells endogenously expressed class I antigens; this was enhanced by rIFN-gamma. Class II antigens could not be detected on RINm5F cells, but both I-A and I-E were induced by rIFN-gamma.
Varey
A M
AM
Department of Immunology, Middlesex Hospital Medical School, London, England.
Lydyard
P M
PM
Dean
B M
BM
Van der Meide
P H
PH
Baird
J D
JD
Cooke
A
A
D007516:Adenoma, Islet Cell / Q000276:immunology*; D000818:Animals; D000911:Antibodies, Monoclonal; D002460:Cell Line; D006680:HLA Antigens / Q000145:classification / Q000276:immunology*; D007340:Insulinoma / Q000276:immunology* / Q000473:pathology; D007371:Interferon-gamma / Q000276:immunology*; D010190:Pancreatic Neoplasms / Q000276:immunology* / Q000473:pathology; D011994:Recombinant Proteins
D000911:Antibodies, Monoclonal; D006680:HLA Antigens; D011994:Recombinant Proteins; D007371:Interferon-gamma