The lack of effect of chronic administration of imipramine and electroconvulsive shock on opioid mu, delta and kappa receptors in the spinal cord.
Chronic administration of imipramine (10 mg/kg/day for 21 days) and ECS (8 daily treatments) did not change parameters of specific spinal binding sites for [3H]naloxone, [3H]DADLE and [3H]bremazocine. The results indicate that chronic antidepressant treatment does not affect spinal opioid receptors.
Antkiewicz-Michaluk
L
L
Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Vetulani
J
J
D000818:Animals; D004597:Electroshock; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000378:metabolism* / Q000502:physiology; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D013116:Spinal Cord / Q000378:metabolism*
D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D007099:Imipramine