Asbestos catalyzes the formation of the 6-oxobenzo[a]pyrene radical from 6-hydroxybenzo[a]pyrene.
Crocidolite asbestos catalyzes the oxidation of 6-hydroxybenzo[a]pyrene, a metabolite of benzo[a]pyrene, to the 6-oxobenzo[a]pyrene radical as determined by electron spin resonance spectroscopy. This may be a mechanism whereby inhaled asbestos enhances the incidence of lung cancer induced by cigarette smoke, which contains benzo[a]pyrene.
Graceffa
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Boston Biomedical Research Institute, Department of Muscle Research, Massachusetts 02114.
Weitzman
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D001194:Asbestos; D017638:Asbestos, Crocidolite; D001580:Benzopyrenes; D004578:Electron Spin Resonance Spectroscopy; D007700:Kinetics
D001580:Benzopyrenes; D017638:Asbestos, Crocidolite; D001194:Asbestos; C014729:6-oxybenzo(a)pyrene; C023395:6-hydroxybenzo(a)pyrene