Effects of ZSY-27, a synthesized phosphodiesterase inhibitor, on exocrine secretion and cyclic nucleotide concentration in the dog pancreas.
1. Effects of intravenous injections of ZSY-27, a synthesized phosphodiesterase inhibitor, on pancreatic exocrine secretion and on pancreatic cyclic AMP and cyclic GMP concentrations of dogs were investigated. 2. ZSY-27 (0.3 and 1 mg/kg) increased cyclic AMP concentration dose-dependently, which preceded the increase in pancreatic secretion but did not affect cyclic GMP concentration. 3. These results suggest that ZSY-27 causes exocrine secretion from the dog pancreas mediated through an increase in intracellular cyclic AMP concentration.
Iwatsuki
K
K
Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Horiuchi
A
A
Chiba
S
S
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004285:Dogs; D005260:Female; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D013843:Thiazines / Q000494:pharmacology*
D010726:Phosphodiesterase Inhibitors; D013843:Thiazines; C050142:ZSY 27; D000242:Cyclic AMP; D006152:Cyclic GMP