Effects of nordihydroguaiaretic acid, phloretin, and phloridzin on the activity of adenylate cyclase, lipoxygenase and hexose transport, and growth of cultured keratinocytes.
Compounds related to the flavonoid group of natural products may have potential as antipsoriatic drugs. The dihydrochalcone phloretin, its glycoside derivative phloridzin, and the structurally related compound nordihydroguaiaretic acid (NDGA) were selected for study. Phloretin and NDGA strongly inhibited keratinocyte growth but had no effect on isoproterenol-stimulated adenylate cyclase; phloridzin had no effect on growth but potentiated the response of the enzyme. None had any effect on phosphodiesterase. Neither phloretin or phoridzin inhibited lipoxygenase or, surprisingly, decreased deoxyglucose transport. Phloretin and NDGA should be considered antipsoriatic agents.
Wilkinson
D I
DI
Department of Dermatology, Stanford University School of Medicine, California.
Orenberg
E K
EK
D000262:Adenylyl Cyclases / Q000378:metabolism*; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism*; D001091:Arachidonate Lipoxygenases / Q000378:metabolism*; D002396:Catechols / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D004261:DNA Replication / Q000187:drug effects; D003847:Deoxyglucose / Q000378:metabolism; D006601:Hexoses / Q000378:metabolism*; D006801:Humans; D016859:Lipoxygenase Inhibitors; D009637:Masoprocol / Q000494:pharmacology*; D010693:Phloretin / Q000494:pharmacology; D010695:Phlorhizin / Q000494:pharmacology*; D012867:Skin / Q000166:cytology*
D002396:Catechols; D006601:Hexoses; D016859:Lipoxygenase Inhibitors; D009637:Masoprocol; D003847:Deoxyglucose; D010695:Phlorhizin; D000242:Cyclic AMP; D001091:Arachidonate Lipoxygenases; D001094:Arachidonate 5-Lipoxygenase; D000262:Adenylyl Cyclases; D010693:Phloretin