[Effect of hyaluronidase on the quantum content and binomial p and n parameters of neuromuscular transmission in frogs].
In the frog dermo-sternal muscle hyaluronidase (0.01--0.1%) caused e.p.p. amplitude and quantum content of transmission to fall when acting in a solution containing 1 mM Ca2+ and 4 mM Mg2+. The change in the quantum content was related to a decrease in binomial parameter n, the probability of mediator p release increased in the first moments of the enzyme action. With the prolongation of hyaluronidase action, negative values of p appeared. Hyaluronidase caused an increase in e.p.p. amplitude and in quantum content of transmission when acting in a solution containing 8 mM Ca2+ and d-tubocurarine. It was suggested that hyaluronidase modifies the normal calcium exchange between the bulk solution and the unstirred layer near nerve terminal membrane thus affecting the transmission.
Vinogradova
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D000818:Animals; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D011789:Quantum Theory; D011898:Ranidae; D009435:Synaptic Transmission / Q000187:drug effects*
D006821:Hyaluronoglucosaminidase
Vliianie gialuronidazy na kvantovyĭ sostav i binomialnye parametry P i N nervno-myshechnoĭ peredachi u liagushki.