Effect of carbenoxolone on glucose metabolism in rat adipose tissue.
Carbenoxolone significantly decreased the glucose uptake and the incorporation of glucose into triglycerides and CO2 in rat epididymal fat pads. The effect produced by insulin on these metabolic pathways was reduced when adipose tissue was incubated with insulin in the presence of carbenoxolone (10(-3) M). On the other hand the drug (10(-3) M) produced a decrease in cyclic AMP concentration in adipose tissue similar to that produced by insulin (100 ng/ml).
Gomez-Capilla
J A
JA
Departamento de Bioquimica, Facultad de Medicina, Universidad de Granada, Spain.
Gutierrez
C
C
Fernández-Fernández
J M
JM
D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D002229:Carbenoxolone / Q000494:pharmacology*; D000242:Cyclic AMP / Q000032:analysis; D005947:Glucose / Q000378:metabolism*; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D000242:Cyclic AMP; D005947:Glucose; D002229:Carbenoxolone; D006034:Glycyrrhetinic Acid