title: Subnuclear localization of the trans-activating protein of human T-cell leukemia virus type I.
abstract: Human T-cell leukemia virus type I is associated with human lymphoid malignancies. The p40xI protein encoded by the x gene of this virus is believed to play some role in virally mediated transformation. This gene is known to encode a transcriptional trans activator which previous studies have shown to be a nuclear protein. Further characterization of the intracellular kinetics of this protein showed that it migrated into the nucleus very soon after synthesis. Within the nucleus, p40xI was distributed almost equally between the nucleoplasm and the nuclear matrix. Given the proposed role of the nuclear matrix in RNA transcription, the association of p40xI with the matrix places it in an appropriate cellular compartment to exercise an effect on transcription.
authors.affiliation: Department of Medicine, University of California, Los Angeles School of Medicine 90024.
authors.forename: D J
authors.initials: DJ
authors.lastname: Slamon
authors.forename: W J
authors.initials: WJ
authors.lastname: Boyle
authors.forename: D E
authors.initials: DE
authors.lastname: Keith
authors.forename: M F
authors.initials: MF
authors.lastname: Press
authors.forename: D W
authors.initials: DW
authors.lastname: Golde
authors.forename: L M
authors.initials: LM
authors.lastname: Souza
mesh_terms: D002451:Cell Compartmentation; D002467:Cell Nucleus / Q000032:analysis / Q000648:ultrastructure*; D017977:Deltaretrovirus / Q000032:analysis*; D006801:Humans; D012191:Retroviridae Proteins / Q000032:analysis*; D013601:T-Lymphocytes / Q000648:ultrastructure; D015534:Trans-Activators; D014157:Transcription Factors / Q000032:analysis*; D014158:Transcription, Genetic
chemical_list: D012191:Retroviridae Proteins; D015534:Trans-Activators; D014157:Transcription Factors