[Histiocytosis X of the jaws. II. Structural, histo-enzymologic and immunohistochemical study].
A series of cases of histiocytosis X was studied by immunohistochemistry (20 cases), histoenzymology (5 cases) and electron microscopy (15 cases). The immunohistochemical methods showed in the majority of cells (histiocytes similar to Langerhans' cells), OKT6, HLA-DR ans S-100 protein antigens. Besides, Leu 4 antigen was also present on the surface of some cells. The histoenzymological analysis found acid phosphatase and specific esterases activities with a different repartition in histiocytes compared to macrophages. By electron microscopy, we detected the typical Birbeck granules. The signification of these granules and also the pathogenesis of the disease were discussed.
Chomette
G
G
Service d'Anatomie pathologique, Hôpital de la Pitié, Paris.
Auriol
M
M
Ragot
J P
JP
D005455:Fluorescent Antibody Technique; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron / Q000379:methods; D010744:Phosphoric Monoester Hydrolases / Q000032:analysis
D010744:Phosphoric Monoester Hydrolases
Histiocytose X des maxillaires. II. Etude ultrastructurale, histoenzymologique et immunohistochimique.