title: Influence of standard heparin or low molecular weight heparin on healing of abdominal wounds and colonic anastomoses in rats.
abstract: The influence of standard heparin or low molecular weight (LMW) heparin on healing of abdominal wounds and colonic anastomoses was studied in rats. Subcutaneous injection of 1 XaI U/g b.w. of standard or LMW-heparin or 0.5 ml physiologic saline was given 12 hours preoperatively and daily for 3 or 7 days postoperatively. Breaking strength of the abdominal wound and the anastomosis was measured, as were haemoglobin and albumin in serum. Hydroxyproline as a measure of collagen and tissue dry weight was determined in standardized segments of colonic wall adjacent to the anastomosis. Except for significant increase in breaking strength of the anastomosis after 7-day injection of LMW heparin, no differences in the parameters of wound healing were found after 3 or 7 days. In rats receiving standard heparin there was increased bleeding tendency (reduced haemoglobin) compared with the LMW-heparin group and the controls. The administered heparin thus did not negatively influence healing, and standard and LMW-heparin did not differ in this respect.
authors.affiliation: Department of Surgery, University of Lund, Malmö General Hospital, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Mätzsch
authors.forename: D
authors.initials: D
authors.lastname: Bergqvist
authors.forename: P
authors.initials: P
authors.lastname: Blomquist
authors.forename: H
authors.initials: H
authors.lastname: Jiborn
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000714:Anastomosis, Surgical; D000818:Animals; D003094:Collagen / Q000378:metabolism; D003106:Colon / Q000601:surgery*; D006493:Heparin / Q000627:therapeutic use*; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D008297:Male; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D013718:Tensile Strength; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000378:metabolism / Q000503:physiopathology
chemical_list: D006495:Heparin, Low-Molecular-Weight; D006493:Heparin; D003094:Collagen