Relationships between behavioral rhythms, plasma corticosterone and hypothalamic circadian rhythms.
Circadian rhythms in physiological processes and behaviors were compared with hypothalamic circadian rhythms in norepinephrine (NE) metabolites, adrenergic transmitter receptors, cAMP, cGMP and suprachiasmatic nucleus (SCN) arginine vasopressin (AVP) in a single population of rats under D:D conditions. Eating, drinking and locomotor activity were high during the subjective night (the time when lights were out in L:D) and low during the subjective day (the time when lights were on in L:D). Plasma corticosterone concentration rose at subjective dusk and remained high until subjective dawn. Binding to hypothalamic alpha 1- and beta-adrenergic receptors also peaked during the subjective night. Cyclic cGMP concentration was elevated throughout the 24-hr period except for a trough at dusk, whereas DHPG concentration peaked at dawn. Arginine vasopressin levels in the suprachiasmatic nucleus peaked in the middle of the day. No rhythm was found either in binding to the alpha 2-adrenergic receptor, or in MHPG or cAMP concentration. Behavioral and corticosterone rhythms, therefore, are parallel to rhythms in hypothalamic alpha 1- and beta-receptor binding and NE-release. Cyclic GMP falls only at dusk, suggesting the possibility that cGMP inhibits activity much of the day and that at dusk the inhibition of nocturnal activity is removed. SCN AVP, on the other hand, peaking at 1400 hr, may play a role in the pacemaking function of the SCN that drives these other rhythms.
Kafka
M S
MS
Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, MD 20892.
Benedito
M A
MA
Steele
L K
LK
Gibson
M J
MJ
Zerbe
R L
RL
Jacobowitz
D M
DM
Roth
R H
RH
Zander
K
K
D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism; D001522:Behavior, Animal / Q000502:physiology*; D002940:Circadian Rhythm; D003345:Corticosterone / Q000097:blood*; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011941:Receptors, Adrenergic / Q000378:metabolism; D013493:Suprachiasmatic Nucleus / Q000378:metabolism
D011941:Receptors, Adrenergic; D001127:Arginine Vasopressin; D000242:Cyclic AMP; D006152:Cyclic GMP; D003345:Corticosterone; D009638:Norepinephrine