The effects of levamisole on urinary enzyme measurements and proximal tubule cell inclusions in male rats.
A markedly increased incidence of large angular secondary lysosomes was observed in the proximal tubular cells of male Wistar rats dosed orally with levamisole, 75 mg/kg body weight for 15 days. These inclusions were similar in appearance to those previously observed in male rats treated with decahydronaphthalene. Urinary enzymes were measured throughout the study, and of these enzymes lactate dehydrogenase and N-acetyl-beta-D-glucosaminidase activities were higher on days 9 and 13 for rats dosed with levamisole in comparison with control animals. Urine volumes increased for the levamisole treatment group, but no treatment related changes of urine protein output were found.
Evans
G O
GO
Department of Drug Safety Evaluation, Wellcome Research Laboratories, Beckenham, Kent, UK.
Goodwin
D A
DA
Parsons
C E
CE
Read
N G
NG
D000118:Acetylglucosaminidase / Q000652:urine*; D000818:Animals; D003404:Creatinine / Q000652:urine; D006596:Hexosaminidases / Q000652:urine*; D002479:Inclusion Bodies / Q000648:ultrastructure; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000648:ultrastructure*; D007770:L-Lactate Dehydrogenase / Q000652:urine*; D007978:Levamisole / Q000494:pharmacology*; D008247:Lysosomes / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009994:Osmolar Concentration; D011507:Proteinuria; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D007978:Levamisole; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D006596:Hexosaminidases; D000118:Acetylglucosaminidase