title: Clinical and virological observations on swine experimentally infected with Getah virus.
abstract: The pathogenicity of Getah virus for swine was examined. All 8 pigs (4 adults and 4 piglets) inoculated with Strains MIP-99 and MI-110 developed pyrexia ranging from 39.4 to 40.7 degrees C and anorexia. Mild depression and diarrhea were observed in 2 of the 4 piglets. These clinical signs were transient. Viremia occurred 1-2 days post-inoculation (p.i.) and the maximum titer was 10(3.0) TCID50 0.1 ml-1. The virus was recovered from a piglet autopsied on Day 3 p.i. from spleen and various lymph nodes. The maximum titer of virus (10(3.75) TCID50 0.1 g-1) was detected in the inguinal lymph node. Seroconversion was demonstrated in all the pigs on Day 6 p.i. These results suggest that Getah virus is mildly pathogenic for swine, which may play a role as an amplifying host in nature.
authors.affiliation: Equine Research Institute, Japan Racing Association, Tochigi.
authors.forename: T
authors.initials: T
authors.lastname: Kumanomido
authors.forename: R
authors.initials: R
authors.lastname: Wada
authors.forename: T
authors.initials: T
authors.lastname: Kanemaru
authors.forename: M
authors.initials: M
authors.lastname: Kamada
authors.forename: K
authors.initials: K
authors.lastname: Hirasawa
authors.forename: Y
authors.initials: Y
authors.lastname: Akiyama
mesh_terms: D000524:Alphavirus / Q000276:immunology / Q000472:pathogenicity*; D000818:Animals; D000855:Anorexia / Q000662:veterinary; D000914:Antibodies, Viral / Q000096:biosynthesis; D003967:Diarrhea / Q000382:microbiology / Q000662:veterinary; D005260:Female; D005334:Fever / Q000662:veterinary; D008198:Lymph Nodes / Q000382:microbiology; D008297:Male; D013154:Spleen / Q000382:microbiology; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*; D014036:Togaviridae Infections / Q000382:microbiology / Q000662:veterinary*; D014766:Viremia / Q000662:veterinary
chemical_list: D000914:Antibodies, Viral