title: The acetylcholine receptors of the semicircular canal in the frog (Rana pipiens).
abstract: We present preliminary evidence that acetylcholine has three distinct modes of action on the discharge rate of afferent fibers from the frog isolated semicircular canal. These are: (I) a facilitatory effect which is of mixed muscarinic-nicotinic type and is mediated by a receptor which we call "atropine-preferring'; (II) a suppressive effect unmasked by atropine and antagonized by strychnine whose action is mediated by a "strychnine-preferring" receptor; (III) a suppressive effect produced by the cholinesterase inhibitors eserine and echothiophate, which being antagonized by curare, is mediated by a "curare-preferring" receptor.
authors.affiliation: Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112.
authors.forename: C H
authors.initials: CH
authors.lastname: Norris
authors.forename: G D
authors.initials: GD
authors.lastname: Housley
authors.forename: W H
authors.initials: WH
authors.lastname: Williams
authors.forename: S L
authors.initials: SL
authors.lastname: Guth
authors.forename: P S
authors.initials: PS
authors.lastname: Guth
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology / Q000502:physiology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D066298:In Vitro Techniques; D011894:Rana pipiens / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D012665:Semicircular Canals / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D013331:Strychnine / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects; D014403:Tubocurarine / Q000494:pharmacology
chemical_list: D011950:Receptors, Cholinergic; D001285:Atropine; D013331:Strychnine; D000109:Acetylcholine; D014403:Tubocurarine