title: Chromosomal patterns in human malignant astrocytomas.
abstract: Cytogenetic analysis by direct and/or in vitro preparations was performed on 34 malignant astrocytomas. Thirty tumors showed near-diploid chromosome numbers, whereas, tritetraploid chromosome complements were present in four tumors. The most frequent chromosomal changes implied numerical deviations by a gain of chromosomes #7, #19, and #20, and by losses of #10, #22, and Y. Structural rearrangements were present in stem- or side lines of 24 tumors. Although no common chromosomal rearrangement seems to exist among those tumors, chromosomes #1, #6, #7, and #9 were predominantly involved. Polysomy and structural rearrangements of chromosome #7 could be related to the overexpression of epidermal growth factor gene, previously observed in some malignant gliomas.
authors.affiliation: Department of Genetics, Fundación Jiménez Díaz, Madrid, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Rey
authors.forename: M J
authors.initials: MJ
authors.lastname: Bello
authors.forename: J M
authors.initials: JM
authors.lastname: de Campos
authors.forename: M E
authors.initials: ME
authors.lastname: Kusak
authors.forename: C
authors.initials: C
authors.lastname: Ramos
authors.forename: J
authors.initials: J
authors.lastname: Benitez
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D011003:Ploidies