Immunological function of HLA-C antigens in HLA-Cw3 transgenic mice.
The human major histocompatibility complex encodes three classical class I antigens, HLA-A, -B, and -C. Of these HLA-A and -B act as strong transplantation antigens and as restriction molecules for recognition of foreign antigen by cytotoxic T lymphocytes. In contrast, little is known about HLA-C and it is not clear whether HLA-C has the same functional properties as HLA-A and -B. Transgenic C57BL/6 mice expressing the HLA-Cw3 gene were established. Functional studies demonstrated that transgenic skin was rapidly rejected by normal C57BL/6 mice and that cytotoxic T lymphocytes generated by immunization of the Cw3 transgenic mice with influenza and Sendai virus were restricted by the Cw3 molecule. These data suggest that HLA-Cw3 has immunological functions comparable to those of HLA-A and -B.
Dill
O
O
Institute of Immunology and Genetics, German Cancer Research Center, Heidelberg.
Kievits
F
F
Koch
S
S
Ivanyi
P
P
Hämmerling
G J
GJ
D000818:Animals; D005434:Flow Cytometry; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology*; D015236:HLA-C Antigens; D007118:Immunoassay; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009975:Orthomyxoviridae / Q000276:immunology; D010222:Parainfluenza Virus 1, Human / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D006680:HLA Antigens; D015236:HLA-C Antigens; C038653:HLA-C*03 antigen