title: Serologic characteristics of a human rotavirus isolate, AU-1, which has a "long" RNA pattern and subgroup I specificity.
abstract: An unusual human rotavirus (HRV) isolate, designated AU-1, has a "long" RNA electrophoretic pattern and subgroup I specificity, in contrast to properties common to HRVs previously isolated. Hemagglutination activity of the AU-1 strain was demonstrated using erythrocytes of 1-day-old chicken. Neutralization assays revealed that the AU-1 strain was crossneutralized by hyperimmune antisera against the MO strain (serotype 3). However, antiserum directed against a reassortant in which the gene for Vp7 was replaced by the corresponding AU-1 gene neutralized the AU-1 strain to a significantly higher titer than the MO strain.
authors.affiliation: Department of Pediatrics, Tohoku University, Sendai, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kitaoka
authors.forename: T
authors.initials: T
authors.lastname: Nakagomi
authors.forename: N
authors.initials: N
authors.lastname: Fukuhara
authors.forename: Y
authors.initials: Y
authors.lastname: Hoshino
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: O
authors.initials: O
authors.lastname: Nakagomi
authors.forename: A Z
authors.initials: AZ
authors.lastname: Kapikian
authors.forename: T
authors.initials: T
authors.lastname: Ebina
authors.forename: T
authors.initials: T
authors.lastname: Konno
authors.forename: N
authors.initials: N
authors.lastname: Ishida
mesh_terms: D006386:Hemagglutination Tests; D006801:Humans; D009500:Neutralization Tests; D012367:RNA, Viral / Q000302:isolation & purification; D012401:Rotavirus / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification; D012703:Serotyping; D013045:Species Specificity
chemical_list: D012367:RNA, Viral