Effect of the recombinant vaccinia viruses that express HTLV-I envelope gene on HTLV-I infection.
The human T-lymphotropic virus type I (HTLV-I) is etiologically linked to adult T-cell leukemia (ATL). To develop a vaccine against ATL, we constructed recombinant vaccinia viruses containing the envelope gene of HTLV-I in the vaccinia virus hemagglutinin (HA) gene, a new site where foreign genes can be inserted. A single inoculation of the recombinant virus induced antibodies to the env proteins of HTLV-I in rabbits and had a protective effect against HTLV-I infection.
Shida
H
H
Institute for Virus Research, Kyoto University, Japan.
Tochikura
T
T
Sato
T
T
Konno
T
T
Hirayoshi
K
K
Seki
M
M
Ito
Y
Y
Hatanaka
M
M
Hinuma
Y
Y
Sugimoto
M
M
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis / Q000235:genetics; D002460:Cell Line; D017977:Deltaretrovirus / Q000235:genetics*; D005796:Genes; D005814:Genes, Viral; D005822:Genetic Vectors; D010957:Plasmids; D011401:Promoter Regions, Genetic; D011817:Rabbits; D011995:Recombination, Genetic; D014616:Vaccinia virus / Q000235:genetics*; D014759:Viral Envelope Proteins / Q000235:genetics*
D000956:Antigens, Viral; D014759:Viral Envelope Proteins