Calcium and neuronal cytoskeletal proteins: alterations with aging.
Calcium plays a major role in regulating cellular function. Alterations in calcium systems may underlie some of the physiological changes associated with aging. Calcium activates calmodulin-dependent protein kinase, and this enzyme mediates some effects of calcium on cellular function. Calcium/calmodulin-dependent kinase II may play a significant role in specific cytoskeletal abnormalities of normal aging and selected neurodegenerative diseases.
Harris
J K
JK
DeLorenzo
R J
RJ
D000368:Aged; D000375:Aging / Q000378:metabolism* / Q000502:physiology; D000544:Alzheimer Disease / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D003599:Cytoskeleton / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D010770:Phosphotransferases / Q000378:metabolism
D002147:Calmodulin; D003598:Cytoskeletal Proteins; D010770:Phosphotransferases; D002118:Calcium