title: Mouse ovarian tumors--a review including classification and induction of neoplastic lesions and description of several previously unreported types.
abstract: The purpose of this study is to review the pertinent literature on the incidence, methods of induction and pathogenesis of ovarian tumors of mice. Strains of mice with a high incidence of spontaneously occurring granulosa cell tumors (gct) and tubular adenomas (ta) are the C3HeB/Fe and C3HeB/De; strain HAN:NMRI developed Sertoli cell tumors and (DBA x Ce)F1 hybrids had a high incidence gct. Ninety-five percent of hybrid (C57BL/6J x C3H/HeJ)F1 WxWv mice which lack germ cells develop complex tubular adenomas. Strain LT, in which a high percentage of ovarian ova develop parthenogenetically, develops has a high incidence of teratomas. The use of hormones, castration and transplantation of the ovaries in a number of inbred strains results in a high incidence of ovarian tumors; in strain Maf/Sp gct and luteomas were induced in 82%. Irradiation with gamma rays produced a similar incidence of ovarian tumors in (C57L x A)F1 hybrids. The chemical inducing the highest incidence (92%) of ovarian tumors of mice is 9,10 Dimethyl 1,2 benzanthracene (DMBA). Recently, 4-Vinylcyclohexene was shown to induce a high incidence of ovarian tumors. A number of rare ovarian tumors were reported. Described are five androblastomas composed of either Leydig or Sertoli cells or a combination of the two cell types and a single undifferentiated androblastoma. Seven teratomas were described, three of which contained large amounts of neural tissue; another was classified as a teratoma with a parieto-visceral yolk-sac carcinoma component.
authors.affiliation: Registry of Experimental Cancers, NIH, Bethesda, MD 20892.
authors.forename: A G
authors.initials: AG
authors.lastname: Liebelt
authors.forename: B
authors.initials: B
authors.lastname: Sass
authors.forename: L S
authors.initials: LS
authors.lastname: Lombard
mesh_terms: D000236:Adenoma / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D000818:Animals; D003537:Cystadenoma / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D005260:Female; D006106:Granulosa Cell Tumor / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D010051:Ovarian Neoplasms / Q000145:classification / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D018310:Sertoli-Leydig Cell Tumor / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D013798:Thecoma / Q000453:epidemiology / Q000209:etiology / Q000473:pathology