Steroid hormone and epidermal growth factor receptors in meningiomas.
A prospective study of steroid hormone and epidermal growth factor receptor expression in 57 meningiomas is presented. Scatchard analysis of radioligand binding identified 20% of meningiomas as expressing classical oestrogen receptors (ER) at levels below that normally accepted for positivity, the remainder being negative. ER could not be visualized in any meningioma using immunocytochemistry. Alternatively, 74% of meningiomas demonstrated the presence of progesterone receptors (PR) by Scatchard analysis, the specificity of which could not be attributed to glucocorticoid or androgen receptors. Confirmation of classical PR presence was determined by immunocytochemical staining. The presence of epidermal growth factor receptor (EGFR) was demonstrated in 100% of meningiomas using immunocytochemical staining. These data are reviewed in the context of previously reported results and are discussed in relation to the potential for medical therapy as an adjunct to surgery.
Horsfall
D J
DJ
Department of Surgery, Flinders Medical Centre, Bedford Park, South Australia.
Goldsmith
K G
KG
Ricciardelli
C
C
Skinner
J M
JM
Tilley
W D
WD
Marshall
V R
VR
D000328:Adult; D000368:Aged; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006394:Hemangiosarcoma / Q000032:analysis; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000032:analysis*; D008579:Meningioma / Q000032:analysis*; D008875:Middle Aged; D011446:Prospective Studies; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D066246:ErbB Receptors