Acute alkalosis, but not acute hypocalcemia, increases panic behavior in an animal model.
Non-pretrained, randomized adult rats were tested in a panic-inducing model of passive avoidance. Intravenous treatment with alkalinizing agents (sodium lactate 0.5 M, 0.5 ml/100 g b.wt., or NaHCO3, 0.5 mEq/100 g b.wt.), but not with a hypocalcemic dose of EDTA (75 mg/kg) 3 min before testing, significantly increased panic behavior. These data may support the hypothesis that panic attacks are due to alkalosis and not to lactate-induced hypocalcemia.
Di Lorenzo
R
R
Institute of Pharmacology, University of Modena, Italy.
Bernardi
M
M
Genedani
S
S
Zirilli
E
E
Grossi
G
G
Guaraldi
G P
GP
Bertolini
A
A
D000471:Alkalosis / Q000523:psychology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001639:Bicarbonates / Q000494:pharmacology; D005239:Fear / Q000502:physiology*; D005260:Female; D006996:Hypocalcemia / Q000523:psychology*; D007773:Lactates / Q000494:pharmacology; D019344:Lactic Acid; D010200:Panic / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000494:pharmacology; D017693:Sodium Bicarbonate
D001639:Bicarbonates; D007773:Lactates; D019344:Lactic Acid; D017693:Sodium Bicarbonate; D012964:Sodium