[Effectiveness of preoperative transcatheter arterial embolization for improved survival rates in patients with hepatocellular carcinomas (sandwich therapy using ethiodized oil, cisplatin and gelatin sponge].
The effect of hepatic transcatheter arterial embolization (TAE) therapy was evaluated in 153 patients with hepatocellular carcinomas who underwent radical hepatectomy. They were divided into 3 groups. Group A (n = 56) received preoperative TAE using ethiodized oil, cisplatin and gelatin sponge (sandwich therapy). Group B (n = 29) received preoperative TAE using adriamycin + gelatin sponge, ethiodized oil + adriamycin + gelatin sponge or adriamycin + degradable starch microsphere. Group C (n = 68) did not receive TAE preoperatively. The 3-year disease-free survival rates in Group A, B, and C were 56%, 34% and 32%, respectively. The rate was significantly higher in Group A than Group C (p less than 0.05). The 1-year disease-free survival rates after partial hepatectomy were 89% in Group A (n = 22), 53% in Group B (n = 15) and 67% in Group C (n = 22). The 3-year survival rate of these patients in Group A was significantly higher (95%), compared to Group C (70%) (p less than 0.05). Preoperative TAE using ethiodized oil, cisplatin and gelatin sponge (sandwich therapy) was considered a useful therapy for improvement of disease-free survival rates or survival rates after hepatectomy in patients with hepatocellular carcinomas.
Shibata
T
T
Dept. of Surgery, Center for Adult Disease, Osaka.
Sasaki
Y
Y
Imaoka
S
S
Yasuda
T
T
Wada
H
H
Ishikawa
O
O
Ohigashi
H
H
Fukuda
I
I
Kabuto
T
T
Hiratsuka
M
M
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D004621:Embolization, Therapeutic / Q000379:methods / Q000401:mortality; D004998:Ethiodized Oil / Q000008:administration & dosage*; D005260:Female; D005781:Gelatin Sponge, Absorbable / Q000008:administration & dosage*; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care
D004998:Ethiodized Oil; D004317:Doxorubicin; D002945:Cisplatin