Effects of chlorhexidine, NaF and SnF2 on glucan formation by salivary and culture supernatant GTF adsorbed to hydroxyapatite.
Chlorhexidine, NaF and SnF2 were tested for inhibitory activity against glucosyltransferase (GTF) which had been adsorbed to hydroxyapatite. The sources of GTF were culture supernatants of S. mutans grown in BHI or stimulated whole saliva supernatants. Chlorhexidine inhibited GTF activity from culture supernatants as well as from saliva. NaF and SnF2 had moderate effects.
Scheie
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AA
Institute of Microbiology and Physiology, Dental Faculty, University of Oslo, Norway.
Kjeilen
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JC
D000327:Adsorption; D002710:Chlorhexidine / Q000494:pharmacology*; D003773:Dental Plaque / Q000517:prevention & control; D017886:Durapatite; D005459:Fluorides / Q000494:pharmacology*; D005936:Glucans / Q000096:biosynthesis*; D005964:Glucosyltransferases / Q000378:metabolism*; D006801:Humans; D006882:Hydroxyapatites; D012463:Saliva / Q000201:enzymology*; D012969:Sodium Fluoride / Q000494:pharmacology*; D013295:Streptococcus mutans / Q000201:enzymology; D014002:Tin Fluorides / Q000494:pharmacology*
D005936:Glucans; D006882:Hydroxyapatites; D014002:Tin Fluorides; D012969:Sodium Fluoride; D017886:Durapatite; D005964:Glucosyltransferases; D005459:Fluorides; D002710:Chlorhexidine