Learning and memory processes of an ACTH4-9 analog (ebiratide; Hoe 427) in mice and rats.
These experiments investigated the effects of the new ACTH4-9 analog ebiratide (Hoe 427) [H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH-(CH2)8-NH2 X 3 CH3COOH] on memory processes in mice and rats in five training tasks. With all five training and testing procedures (inhibitory avoidance test with ECS- or scopolamine-induced amnesia, up-hill avoidance, one-way shuttle box avoidance and eight-arm radial maze) ebiratide was most effective in a dose range of 1-10 micrograms/kg SC.
Hock
F J
FJ
HOECHST AG, Department of Pharmacology, Frankfurt/M, Federal Republic of Germany.
Gerhards
H J
HJ
Wiemer
G
G
Usinger
P
P
Geiger
R
R
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004597:Electroshock; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D010446:Peptide Fragments / Q000494:pharmacology*; D012016:Reference Values; D012601:Scopolamine / Q000494:pharmacology; D012934:Social Isolation
D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; C057139:ebiratide; D012601:Scopolamine