Conditions for radioiodination of antithrombin III retaining its biological properties.
In order to obtain a radioiodinated antithrombin III (AT III) with a good labelling yield and optimal biological properties towards heparin, thrombin and its anti-AT III monoclonal antibodies, we compared the classical labelling methods and found them wanting. Thus, we perfected a new labelling procedure which fulfils the above requirements.
Caix
J
J
CNRS No. 48 Haemocompatible Polymers, CHU Bordeaux, France.
Perrot Minnot
A
A
Beziade
A
A
Vuillemin
L
L
Belloc
F
F
Baquey
C
C
Ducassou
D
D
D000990:Antithrombin III / Q000302:isolation & purification / Q000378:metabolism* / Q000592:standards; D002846:Chromatography, Affinity; D006493:Heparin / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes; D011786:Quality Control; D011865:Radioisotope Dilution Technique; D013917:Thrombin / Q000378:metabolism
D007457:Iodine Radioisotopes; D000990:Antithrombin III; D006493:Heparin; D013917:Thrombin