title: Pituitary and adrenal functions during late asthmatic responses.
abstract: The purpose of the present study was to examine the role of low cortisol levels which were observed during late asthmatic responses (LAR). Selective functions of the adrenals and pituitary glands were studied in three groups of asthmatics who showed LAR, immediate asthmatic responses (IAR), and DAR (dual asthmatic responses). Serial plasma ACTH levels in each group showed no apparent abnormalities when compared with diurnal levels. The cortisol response to ACTH changed within the normal range in all three groups with minor differences. We suggest that low cortisol levels that appear during LAR are not principally due to any dysfunction in the pituitary adrenal system.
authors.affiliation: College of Medical Care and Technology, Gunma University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakazawa
authors.forename: S
authors.initials: S
authors.lastname: Matsui
authors.forename: A
authors.initials: A
authors.lastname: Saitoh
authors.forename: Y
authors.initials: Y
authors.lastname: Umegae
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshie
authors.forename: R
authors.initials: R
authors.lastname: Fueki
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D000293:Adolescent; D000311:Adrenal Glands / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000627:therapeutic use; D000328:Adult; D001249:Asthma / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007267:Injections; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone