Harvey sarcoma virus genome contains no extensive sequences unrelated to those of other retroviruses except ras.
The Harvey murine sarcoma virus genome contains two rat-derived sets of genetic information recombined with the Moloney mouse leukemia virus. The rat sequences represent a ras oncogene and a rat VL30 element. The VL30 sequences have several discrete regions of similarity with retroviral sequences which were detected by searching a protein database for similarities with predicted polypeptide sequences from the VL30 regions. On the 5' side, the most similar sequences were those of feline sarcoma viruses; on the 3' side, murine leukemia viruses were the most similar. Some of the regions of similarity could also be detected directly by searching a nucleic acid sequence database with the viral DNA sequences. The most extensive region of similarity was that which corresponded to the endonuclease in the pol gene of a murine leukemia virus. The majority of the rat-derived sequences present in the Harvey sarcoma virus genome can now be attributed exclusively to ras or retrovirus- or retrotransposon-related sequences.
Manly
K F
KF
Department of Cell and Molecular Biology, Roswell Park Memorial Institute, Buffalo, New York 14263.
Anderson
G R
GR
Stoler
D L
DL
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics; D005814:Genes, Viral; D011905:Genes, ras; D006251:Harvey murine sarcoma virus / Q000235:genetics*; D009052:Leukemia Virus, Murine / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats; D012190:Retroviridae / Q000235:genetics*; D009053:Sarcoma Viruses, Murine / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics
D004279:DNA, Viral; D014764:Viral Proteins