title: [Efficacy of nifedipine on refractory hypoxemia associated with diaphragmatic hernia in the newborn infant. Apropos of a case].
abstract: A 3,200 g birth weight, 38-week gestational age neonate developed very severe persistent pulmonary hypertension following surgical repair of a left diaphragmatic hernia. Despite administration of dopamine, dobutamine, and tolazoline, a significant alveolar-arterial oxygen difference (660 mmHg) was found at age 41 hours. Nifedipine was then administered sublingually in a dose of 1 mg/kg and produced an immediate and dramatic improvement in the right radial artery pO2 that was sustained despite persistence of the right-to-left shunt. We discuss the mode of action of this vasodilating agent that, when added to major therapeutic agents, proved capable of completely reversing a hazardous neonatal situation.
authors.forename: A
authors.initials: A
authors.lastname: Burguet
authors.forename: A
authors.initials: A
authors.lastname: Menget
authors.forename: C
authors.initials: C
authors.lastname: Fromentin
authors.forename: R
authors.initials: R
authors.lastname: Destuynder
mesh_terms: D004341:Drug Evaluation; D006548:Hernia, Diaphragmatic / Q000601:surgery; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology*; D000860:Hypoxia / Q000188:drug therapy / Q000209:etiology*; D007231:Infant, Newborn; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use*; D011183:Postoperative Complications
chemical_list: D009543:Nifedipine
vernacular_title: Efficacité de la nifédipine sur l'hypoxémie réfractaire associée à la hernie diaphragmatique du nouveau-né. A propos d'une observation.