Airway constriction by isocapnic hyperventilation of cold, dry air: comparison of magnitude and duration of protection by nedocromil sodium and sodium cromoglycate.
The protective effect of 1, 2 and 4 mg of nedocromil sodium against airway constriction induced by hyperventilation of cold, dry air was compared with 10 mg sodium cromoglycate and placebo in a double-blind randomized trial. On 5 days, twelve asthmatic subjects received one of the trial medications from a metered dose inhaler. Twenty minutes, 2.5 and 5 hr later, airway responsiveness to hyperventilation of cold, dry air was measured. At 20 min, there was significant protection by all four active medications when compared to placebo, with a trend towards a nedocromil dose relationship but there was no statistical difference between the four active medications. All four showed a similar progressive decrease in protection over 5 hr. The results of this study suggest that nedocromil gives protection against hyperventilation-stimulated airway constriction and that the magnitude and duration of effect for all three doses is similar to 10 mg of cromoglycate.
Juniper
E F
EF
Department of Medicine, St. Joseph's Hospital, Hamilton, Ontario, Canada.
Kline
P A
PA
Morris
M M
MM
Hargreave
F E
FE
D000388:Air; D000402:Airway Obstruction / Q000188:drug therapy* / Q000209:etiology; D001250:Asthma, Exercise-Induced / Q000188:drug therapy; D003080:Cold Temperature / Q000009:adverse effects*; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D006985:Hyperventilation / Q000150:complications*; D008297:Male; D017835:Nedocromil; D011804:Quinolines / Q000627:therapeutic use*; D013147:Spirometry
D011804:Quinolines; D017835:Nedocromil; D004205:Cromolyn Sodium