The fibrolamellar variant of hepatocellular carcinoma. Its association with focal nodular hyperplasia.
A case of fibrolamellar hepatocellular carcinoma (FL-HCC) associated with adjacent focal nodular hyperplasia (FNH) is described. These two regions were adjacent but distinct, both on gross and microscopic examination. Currently, it is unclear whether FL-HCC rarely arises in preexisting FNH, or whether FNH is a typical response to this vascular variant of hepatocellular carcinoma (HCC). The FNH region, which is peripheral, may be biopsied to exclude the underlying carcinoma, and thus lead to inadequate therapy. Previous reports of this association are reviewed.
Saul
S H
SH
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104.
Titelbaum
D S
DS
Gansler
T S
TS
Varello
M
M
Burke
D R
DR
Atkinson
B F
BF
Rosato
E F
EF
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000150:complications; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000209:etiology / Q000473:pathology*