Protective effects of sodium bicarbonate on murine ochratoxicosis.
The protective effect of sodium bicarbonate (NaHCO3), a urine modifier, to alleviate murine ochratoxicosis was investigated. The study included two trials. Urinary pH was altered before oral administration of ochratoxin A (OA) in Trial 1, and animals were given combined doses of OA and ethyl biscoumacetate (Eb) in Trial 2. Acute toxicity of OA as measured by LD50 values was reduced by 23% and 20% in rats treated with NaHCO3 for Trials 1 and 2 respectively. Bicarbonate-treated rats dosed with 20 mg/kg OA or with a combination dose of OA at 17 mg/kg and Eb at 50 mg/kg, had a lower frequency of histological lesions in kidneys, liver, lung, spleen and heart. Two types of heart lesions found in the present study are described.
Yong
S
S
Animal Sciences Wing, Alberta Environmental Centre, Canada.
Albassam
M
M
Prior
M
M
D000818:Animals; D000931:Antidotes; D001639:Bicarbonates / Q000627:therapeutic use*; D006470:Hemorrhage; D006863:Hydrogen-Ion Concentration; D008297:Male; D009206:Myocardium / Q000473:pathology; D009793:Ochratoxins / Q000633:toxicity*; D051381:Rats; D012964:Sodium / Q000627:therapeutic use*; D017693:Sodium Bicarbonate; D014556:Urine
D000931:Antidotes; D001639:Bicarbonates; D009793:Ochratoxins; C025589:ochratoxin A; D017693:Sodium Bicarbonate; D012964:Sodium