Selective intestinal decontamination of the digestive tract for infection prophylaxis in severely burned patients.
An oral prophylactic antibiotic regimen aiming at suppression of the gram-negative rods and yeasts of the bowel flora was utilised in 48 severely burned patients to prevent burn wound colonisation. Only 17% of the patients had an actual or potential infection. Only one Pseudomonas infection occurred. The effect of this selective gastro-intestinal decontamination is discussed.
Manson
W L
WL
Laboratory for Public Health, Groningen, The Netherlands.
Westerveld
A W
AW
Klasen
H J
HJ
Sauër
E W
EW
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002056:Burns / Q000150:complications*; D004064:Digestive System / Q000382:microbiology*; D004338:Drug Combinations / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D011113:Polymyxins / Q000008:administration & dosage; D013420:Sulfamethoxazole / Q000008:administration & dosage; D014031:Tobramycin / Q000008:administration & dosage; D014295:Trimethoprim / Q000008:administration & dosage; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014946:Wound Infection / Q000517:prevention & control*
D000890:Anti-Infective Agents; D004338:Drug Combinations; D011113:Polymyxins; D000666:Amphotericin B; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole; D014031:Tobramycin