[Clinical research on specific IgE and IgG4 antibodies in allergic children. Correlation specific IgE and IgG4 antibodies to food allergens to other allergic factors].
We examined the correlation specific IgE and IgG4 antibodies to food allergens to other allergic factors in 150 asthmatic children by Multiple Factor Analysis-Type II. The following results were obtained. 1) 3 explanation variables (IgE RIST, Eosinophil count, Family history of allergy) had the strong influence power to 8 objective variables of food allergens. 2) By calculating the category score of explanation variables, the high IgE RAST score to Dermatophagoides farinae group had the strong influence power to the high score groups of IgE RAST and IgG4 antibody titers to food allergens. The fact indicated the linkage between specific IgE and IgG4 antibodies to food allergens to specific IgE antibody to Dermatophagoides farinae. 3) In the same way, the severe group of asthma had the strong influence power to the high score groups of IgE RAST and IgG4 antibody titers to food allergens, and specific IgG4 antibody group had a same directivity of specific IgE antibody group to the other allergic factors. So specific IgG4 antibody may play a "role of reaginic antibody".
Koya
N
N
Suzuki
S
S
Moroi
T
T
Nagata
K
K
Tateno
A
A
Hara
M
M
Iikura
Y
Y
D000293:Adolescent; D000485:Allergens / Q000276:immunology*; D000818:Animals; D000918:Antibody Specificity; D001249:Asthma / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008925:Mites / Q000276:immunology
D000485:Allergens; D007074:Immunoglobulin G; D007073:Immunoglobulin E