Serologic characteristics of a human rotavirus isolate, AU-1, which has a "long" RNA pattern and subgroup I specificity.
An unusual human rotavirus (HRV) isolate, designated AU-1, has a "long" RNA electrophoretic pattern and subgroup I specificity, in contrast to properties common to HRVs previously isolated. Hemagglutination activity of the AU-1 strain was demonstrated using erythrocytes of 1-day-old chicken. Neutralization assays revealed that the AU-1 strain was crossneutralized by hyperimmune antisera against the MO strain (serotype 3). However, antiserum directed against a reassortant in which the gene for Vp7 was replaced by the corresponding AU-1 gene neutralized the AU-1 strain to a significantly higher titer than the MO strain.
Kitaoka
S
S
Department of Pediatrics, Tohoku University, Sendai, Japan.
Nakagomi
T
T
Fukuhara
N
N
Hoshino
Y
Y
Suzuki
H
H
Nakagomi
O
O
Kapikian
A Z
AZ
Ebina
T
T
Konno
T
T
Ishida
N
N
D006386:Hemagglutination Tests; D006801:Humans; D009500:Neutralization Tests; D012367:RNA, Viral / Q000302:isolation & purification; D012401:Rotavirus / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification; D012703:Serotyping; D013045:Species Specificity
D012367:RNA, Viral