Reduction in pulmonary and hepatic respiratory cytochrome contents by fly ash inhalation in rats.
Exposure of rats to fly ash for 15 days, 6 hours daily, inhibited pulmonary and hepatic NADH-oxidase activity. The content of cytochrome b and cytochromes a + a3 was significantly lower in the lungs of the fly-ash-exposed group. However, in liver, fly ash exposure reduced the cytochrome a + a3 level without affecting the cytochrome b content, indicating a tissue-specific effect. Mitochondrial protein content in both organs was the same in both groups.
Chauhan
S S
SS
Department of Biochemistry, V.P. Chest Institute, University of Delhi, India.
Tyagi
S R
SR
Kapoor
R K
RK
Misra
U K
UK
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000280:Administration, Inhalation; D000393:Air Pollutants / Q000633:toxicity; D000818:Animals; D002244:Carbon / Q000008:administration & dosage* / Q000633:toxicity; D060729:Coal Ash; D003580:Cytochromes / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008168:Lung / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009097:Multienzyme Complexes / Q000378:metabolism*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D052638:Particulate Matter; D051381:Rats; D011919:Rats, Inbred Strains
D000393:Air Pollutants; D060729:Coal Ash; D003580:Cytochromes; D009097:Multienzyme Complexes; D052638:Particulate Matter; D002244:Carbon; D000255:Adenosine Triphosphate; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases