Biological properties of dihydro-leukotriene B4, an alternative leukotriene B4 metabolite.
Dihydro-leukotriene B4 (a 5,12-dihydroxy-eicosatrienoic acid) has been shown to be the primary metabolite of leukotriene B4 (LTB4) in a variety of cells other than human polymorphonuclear leukocytes (PMNLs). In this report we show that dihydro-LTB4 is significantly less active than LTB4 in different biological assay systems, i.e. leukocyte chemotaxis, chemokinesis, aggregation, adhesion to endothelium and superoxide anion production. This suggests that primary reduction constitutes a second so far unknown deactivation pathway for LTB4.
Kaever
V
V
Department of Pharmacology and Toxicology, Medical School Hannover, FRG.
Damerau
B
B
Wessel
K
K
Resch
K
K
D002448:Cell Adhesion / Q000187:drug effects; D002449:Cell Aggregation / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism; D007975:Leukotriene B4 / Q000378:metabolism* / Q000494:pharmacology; D013481:Superoxides / Q000096:biosynthesis
D013481:Superoxides; D007975:Leukotriene B4