[Effect of cortisol, its polymeric derivative and adenylate cyclase activators on the content of cyclic AMP in rat thymocytes].
In has been shown that cortisol immobilized on polyvinylpyrrolidone (PVP-GC) affects cyclic AMP production stimulated by adenosine and isoproterenol in rat thymocytes. This effect of PVP-GC is specific for cortisol: antiglucocorticoid progesterone (at a concentration of 10(-5) M) inhibited completely the action of PVP-GC on the intracellular cAMP level. It is suggested that cortisol effect on cAMP production is one of the mechanisms of glucocorticoid hormone action in target cells.
Sergeev
P V
PV
Dukhanin
A S
AS
Semeĭkin
A V
AV
D000241:Adenosine / Q000494:pharmacology; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D000242:Cyclic AMP / Q000096:biosynthesis*; D004789:Enzyme Activation / Q000187:drug effects; D006854:Hydrocortisone / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D011205:Povidone / Q000494:pharmacology; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D012969:Sodium Fluoride / Q000494:pharmacology; D013601:T-Lymphocytes / Q000378:metabolism*
D011374:Progesterone; D012969:Sodium Fluoride; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D011205:Povidone; D000241:Adenosine; D007545:Isoproterenol; D006854:Hydrocortisone
Vliianie kortizola, ego polimernogo proizvodnogo i aktivatorov adenilattsiklazy na soderzhanie tsAMF v timotsitakh krys.