A genetic influence on alveolar cell carcinoma.
Analysis of three siblings with alveolar carcinoma is presented. HLA markers were performed on the index cases and on a normal sibling control. The three affected patients shared HLA-A 28, which was absent in the control sibling. A familial recessive trait may have contributed to the development of alveolar cell carcinoma in this family. This family represents the first reported group of three siblings with alveolar carcinoma.
Paul
S M
SM
Department of Surgery, Jefferson Medical College, Philadelphia, Pennsylvania.
Bacharach
B
B
Goepp
C
C
D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000235:genetics* / Q000473:pathology; D000368:Aged; D006680:HLA Antigens / Q000235:genetics; D015234:HLA-A Antigens; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012907:Smoking
D006680:HLA Antigens; D015234:HLA-A Antigens; C037164:HLA-A28 antigen