[Dynamics of calcitonin secretion in tissue culture of medullary thyroid carcinoma].
Calcitonin secretion dynamics of a medullary thyroid carcinoma in tissue culture was studied by addition of calcium chloride (20 mM), magnesium chloride (20 mM), glucagon (6 x 10(-6) M), and pentagastrin (3 x 10(-6) M). After correction by protein content, calcium caused the greatest release of calcitonin to medium (264%), and glucagon the lowest (48%), in relation to control values. The direct action of glucagon on calcitonin secretion of medullary thyroid carcinoma was confirmed. This system may be also used for testing quimiotherapics acting upon the tumor.
Martin
R C
RC
Toledo
S P
SP
D002116:Calcitonin / Q000378:metabolism*; D002277:Carcinoma / Q000378:metabolism*; D003470:Culture Media; D046508:Culture Techniques; D006801:Humans; D013964:Thyroid Neoplasms / Q000378:metabolism*
D003470:Culture Media; D002116:Calcitonin
Dinâmica da secreção de calcitonina em cultura de tecido de carcinoma medular de tireóide.