title: Site-dependent effects of ions on mu-, delta- and kappa-opioid binding in suspensions of guinea-pig brain membranes.
abstract: NaCl, LiCl, NH4Cl and KCl inhibit the equilibrium binding of peptide agonists at each of the mu-, delta- and kappa-sites; the orders of potencies and the slopes of the dose-response curves are site-dependent. In contrast, the monovalent salt choline chloride inhibits mu- and kappa-binding but has little effect on delta-binding. The profiles of activity of MnCl2, CaCl2 and MgCl2 are also site-dependent but differ markedly from those of the monovalent salts.
authors.affiliation: Unit for Research on Addictive Drugs, University of Aberdeen, Marischal College, U.K.
authors.forename: L E
authors.initials: LE
authors.lastname: Robson
authors.forename: S J
authors.initials: SJ
authors.lastname: Paterson
authors.forename: H W
authors.initials: HW
authors.lastname: Kosterlitz
mesh_terms: D000643:Ammonium Chloride / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D002712:Chlorides / Q000494:pharmacology; D006168:Guinea Pigs; D008094:Lithium / Q000494:pharmacology; D018021:Lithium Chloride; D011189:Potassium Chloride / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism*; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D012965:Sodium Chloride / Q000494:pharmacology
chemical_list: D002712:Chlorides; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D000643:Ammonium Chloride; D012965:Sodium Chloride; D011189:Potassium Chloride; D008094:Lithium; D018021:Lithium Chloride