title: An endogenous ligand for phencyclidine receptors: isolated from human brains.
abstract: Using preparative HPLC, Sephadex G-25 and analytic HPLC, we obtained an active peak inhibiting (3H) PCP receptor binding, with a molecular weight of 3,000 daltons. Another isolation process included acetic acid extraction, Toyopearl HW gel filtration, Sephadex G-10 chromatography and analytic HPLC. An active peak was also observed, which was consistent with that from the first isolation process.
authors.affiliation: Shanghai Medical University, China.
authors.forename: W X
authors.initials: WX
authors.lastname: Lu
authors.forename: Y F
authors.initials: YF
authors.lastname: Liu
authors.forename: Y X
authors.initials: YX
authors.lastname: Zhu
authors.forename: G L
authors.initials: GL
authors.lastname: Xi
authors.forename: A Z
authors.initials: AZ
authors.lastname: Zhang
mesh_terms: D001921:Brain / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008970:Molecular Weight; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D017478:Receptors, Phencyclidine; D014020:Tissue Extracts / Q000378:metabolism
chemical_list: D008024:Ligands; D017981:Receptors, Neurotransmitter; D011957:Receptors, Opioid; D017478:Receptors, Phencyclidine; D014020:Tissue Extracts