Repeated electroconvulsive shock does not change [3H]-paroxetine binding to the 5-HT uptake site in rat cortical membranes.
The effects of repeated electroconvulsive shock on the 5-HT uptake site were studied in rat cortex using [3H]-paroxetine binding. This ligand was used because it is thought to directly label the 5-HT uptake site, whereas [3H]-imipramine may bind to a presynaptic recognition site different from the uptake site. No changes were found in the maximum number of [3H]-paroxetine binding sites and equilibrium dissociation constant after repeated electroconvulsive shock, whereas a parallel investigation of beta-adrenoceptor binding showed the expected decrease in receptor number.
Gleiter
C H
CH
Laboratory of Clinical Studies, DICBR, National Institute on Alcoholism and Alcohol Abuse, Bethesda, MD 20892.
Nutt
D J
DJ
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D004597:Electroshock; D008297:Male; D017374:Paroxetine; D010880:Piperidines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000378:metabolism*; D014316:Tritium
D010880:Piperidines; D011943:Receptors, Adrenergic, beta; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D014316:Tritium; D017374:Paroxetine