[Localization of an ACTH-producing pituitary microadenoma using bilateral and simultaneous catheterization of the inferior petrosal sinus].
The experience with bilateral simultaneous inferior petrosal sinus catheterization and determination of the ACTH-concentration in 21 patients is reported. Venous blood sampling in the right and left inferior petrosal sinus was obtained before and after stimulation with Corticotropin-Releasing-Hormone (CRH). In 13 patients with Cushing's Syndrome a ACTH gradient (central versus peripheral) was measured. In all patients who were operated (11/13) a microadenoma was confirmed. In all patients with a central/peripheral gradient of the ACTH-levels at the same time an ipsi versus contralateral gradient between the two sides could be established after administration of CRH, which allowed a correct localization of the microadenoma. In 11 of 13 patients the site of the microadenoma was confirmed intraoperatively.
Bohndorf
K
K
Abetilung Radiologische Diagnostik des Klinikums der RWTH Aachen.
Günther
R W
RW
Vorwerk
D
D
Allolio
B
B
Benker
G
G
Winkelmann
W
W
Windeck
R
R
Schulte
H M
HM
D000236:Adenoma / Q000097:blood / Q000175:diagnosis*; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D002406:Catheterization, Peripheral; D003346:Corticotropin-Releasing Hormone; D003392:Cranial Sinuses; D003480:Cushing Syndrome / Q000097:blood; D006801:Humans; D010911:Pituitary Neoplasms / Q000097:blood / Q000175:diagnosis*
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone
Lokalisation hypophysärer, ACTH-produzierender Mikroadenome mittels bilateraler und simultaner Katheterisierung des Sinus petrosus inferior.