title: Effect of atrial natriuretic factor on corticosteroid production by perifused frog interrenal slices.
abstract: In order to investigate a possible role of atrial natriuretic factor (ANF) in the control of corticosteroid biosynthesis in amphibians, we have examined the effect of synthetic ANF (Arg 101-Tyr 126) on perifused frog interrenal slices. ANF did not affect the spontaneous secretion of corticosterone and aldosterone. In contrast, ANF (10(-6) M) inhibited ACTH-and angiotensin II-stimulated corticosteroid production. ANF was more potent in suppressing aldosterone than corticosterone secretion. Immunocytochemical studies using a specific ANF antiserum revealed the presence of ANF-like immunoreactive fibers in the vicinity of interrenal cells. It is thus proposed that, in amphibians, both "hormonal" ANF secreted by myocytes and "neurohormonal" ANF delivered by peptidergic nerve terminals coursing among interrenal cells may partake in the regulation of corticosteroidogenesis.
authors.affiliation: Université de Rouen, Mont-Saint-Aignan, France.
authors.forename: I
authors.initials: I
authors.lastname: Lihrmann
authors.forename: P
authors.initials: P
authors.lastname: Netchitaïlo
authors.forename: M
authors.initials: M
authors.lastname: Feuilloley
authors.forename: M
authors.initials: M
authors.lastname: Cantin
authors.forename: C
authors.initials: C
authors.lastname: Delarue
authors.forename: F
authors.initials: F
authors.lastname: Leboulenger
authors.forename: A
authors.initials: A
authors.lastname: De Léan
authors.forename: H
authors.initials: H
authors.lastname: Vaudry
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000096:biosynthesis* / Q000378:metabolism; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D003345:Corticosterone / Q000096:biosynthesis* / Q000378:metabolism; D007401:Interrenal Gland / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011895:Rana ridibunda / Q000378:metabolism*; D011898:Ranidae / Q000378:metabolism*
chemical_list: D010446:Peptide Fragments; D000804:Angiotensin II; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D000324:Adrenocorticotropic Hormone; C043970:atrial natriuretic factor 26, rat; D003345:Corticosterone