title: Distribution of vitamin B12 R-binder in carcinomas of the digestive tract.
abstract: To evaluate whether the increase in serum transcobalamin I, seen in patients with carcinoma, is caused by synthesis of R-binder to tumour cells, the distribution of vitamin B12 R-binder in 125 malignant growths of the digestive tract was studied. Positive staining for R-binder with immunoperoxidase was observed in 85 (70%) carcinomas. Positive staining for R-binder was observed in all four cholangiocarcinomas studied, but was absent in nine hepatocellular carcinomas. These findings suggest that determination of R-binder in liver tumours may be of some value in differentiating hepatocellular carcinomas and cholangiocarcinoma, and that synthesis of R-binder by tumour cells causes an increase in serum transcobalamin I.
authors.affiliation: Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kudo
authors.forename: G
authors.initials: G
authors.lastname: Ohshio
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
authors.forename: Y C
authors.initials: YC
authors.lastname: Kim
authors.forename: Y
authors.initials: Y
authors.lastname: Wakatsuki
authors.forename: Y
authors.initials: Y
authors.lastname: Nakashima
authors.forename: H
authors.initials: H
authors.lastname: Yamabe
authors.forename: M
authors.initials: M
authors.lastname: Inada
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism; D002759:Adenoma, Bile Duct / Q000378:metabolism; D001650:Bile Duct Neoplasms / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D004067:Digestive System Neoplasms / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000378:metabolism; D014018:Tissue Distribution; D014155:Transcobalamins / Q000378:metabolism*
chemical_list: D014155:Transcobalamins