[The state of the central glucoreceptor mechanism of the regulation of gastric secretion in patients with duodenal ulcer with different variants of its course].
The time course of the levels of glycemia, gastric secretion of acid and pepsin, and indices of variation pulsometry in response to intravenous injection of glucose (0.66 g/kg) was studied in 42 patients with duodenal ulcer and in 11 healthy persons. It was established that in duodenal ulcer the reactivity of the central glucoreceptor mechanism regulating acid and pepsin secretion, was considerably elevated, especially in patients with complicated forms of disease and gastric hypersecretion. A hyperglycemia-induced degree of acid and pepsin secretion suppression was 1.5- 2-fold higher in the study group than in the control group. The authors proposed that the ratio of a degree of a decrease in acid production (delta % AP) and pepsin production (delta % PP) to the level of glycemia increment (delta % Gl)--acid-glucose (delta % AP/delta % Gl) and pepsin-glucose (delta % PP/delta % Gl) indices should be calculated for overall assessment of a reaction to hyperglycemia of the hypothalamic glucose sensitive mechanism of gastric secretion regulation. These indices reflected a degree of hypothalamic dysfunctions and could serve as markers of the gravity of disease. In the patients with uncomplicated duodenal ulcer as compared to the control group, the acid-glucose index was 2.6-fold and the pepsin-glucose index 1.6-fold higher, and in the patients with complicated duodenal ulcer the indices were 4.6- and 2.9-fold higher, respectively; the indices were higher in the patients with basal acid hypersecretion and hyperplasia of parietal cells.
Fisher
A A
AA
Shevchenko
O A
OA
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D004381:Duodenal Ulcer / Q000503:physiopathology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005947:Glucose / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010434:Pepsin A / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology*
D001786:Blood Glucose; D011956:Receptors, Cell Surface; C027786:glucose receptor; D010434:Pepsin A; D005947:Glucose
Sostoianie tsentral'nogo gliukoretseptornogo mekhanizma reguliatsii zheludochnoĭ sekretsii u bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki s raznymi variantami techeniia.