Gene conversions in the horse alpha-globin gene complex.
The sequences of the linked alpha 2- and alpha 1-globin genes of the equine BI and BII haplotypes are greater than 99% identical within a 1.2-kb region extending from approximately 75 bp upstream of the putative cap site to a point approximately 150 bp 3' to the poly A addition signal. Differences between the alpha 2 and alpha 1 genes that are common to both haplotypes indicate that a major gene conversion occurred approximately 12 Myr ago and that this has been followed by shorter, more localized, conversions. Interhaplotype (allelic) comparisons at the alpha loci suggest that the BI and BII haplotypes have probably existed independently greater than or equal to 0.5 Myr and that the alpha 1 genes may have undergone a recent interchromosomal gene conversion.
Clegg
J B
JB
MRC Molecular Haematology Unit, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom.
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes; D005785:Gene Conversion; D005914:Globins / Q000235:genetics*; D006239:Haplotypes; D006736:Horses / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D011110:Polymorphism, Genetic
D005914:Globins; D004262:DNA Restriction Enzymes