Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila.
Studies of presynaptic events in synaptic transmission may be facilitated through the use of specific ligands for functional components of the transmitter release mechanism and through the use of genetics. For this purpose, neurotoxins that affect neuromuscular transmission in Drosophila have been identified and purified from Plectreurys spider venom (PLTX). One class of toxins causes irreversible presynaptic block, probably by blocking calcium entry or by acting on other closely associated processes. These toxins have been highly purified and are peptides of about 7 kDa in molecular weight. They specifically block transmitter release at nanomolar concentrations and may be useful in further biochemical studies.
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Howard Hughes Medical Institute, University of California, San Francisco 94143.
Kolton
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D000818:Animals; D001180:Arthropod Venoms / Q000494:pharmacology*; D004330:Drosophila; D009469:Neuromuscular Junction / Q000187:drug effects; D009498:Neurotoxins / Q000494:pharmacology*; D013111:Spider Venoms / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects
D001180:Arthropod Venoms; D009498:Neurotoxins; D013111:Spider Venoms