HTLV-V: a new human retrovirus isolated in a Tac-negative T cell lymphoma/leukemia.
A new human retrovirus was isolated from a continuous cell line derived from a patient with CD4+ Tac- cutaneous T cell lymphoma/leukemia. This virus is related to but distinct from human T cell leukemia/lymphoma virus types I and II (HTLV-I and HTLV-II) and human immunodeficiency virus (HIV-1). With the use of a fragment of provirus cloned from one patient with T cell leukemia, closely related sequences were found in DNA of the cell line and of tumor cells from seven other patients with the same disease; these sequences were only distantly related to HTLV-I. The phenotype of the cells and the clinical course of the disease were clearly distinguishable from leukemia associated with HTLV-I. All patients and the wife of one patient showed a weak serological cross-reactivity with both HTLV-I and HIV-1 antigens. None of the patients proved to be at any apparent risk for HIV-1 infection. The name proposed for this virus is HTLV-V, and the date indicate that it may be a primary etiological factor in the major group of cutaneous T cell lymphomas/leukemias, including the sporadic lymphomas known as mycoses fungoides.
Manzari
V
V
Dipartimento di Medicina Sperimentale e Scienze Biochimiche II, Università di Roma, Tor Vergata, Italy.
Gismondi
A
A
Barillari
G
G
Morrone
S
S
Modesti
A
A
Albonici
L
L
De Marchis
L
L
Fazio
V
V
Gradilone
A
A
Zani
M
M
D000956:Antigens, Viral / Q000032:analysis; D017977:Deltaretrovirus / Q000145:classification / Q000302:isolation & purification* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007938:Leukemia / Q000382:microbiology*; D008223:Lymphoma / Q000382:microbiology*; D008297:Male; D008854:Microscopy, Electron; D013601:T-Lymphocytes / Q000166:cytology
D000956:Antigens, Viral