title: Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover.
abstract: The blastogenic transformation of lymphocytes by periodic acid was investigated to determine if blastogenesis induced by this mitogen was preceded by phosphoinositide turnover as previously shown for the lectins. Although periodate oxidation stimulated nucleic acid synthesis and interleukin-2 production, no changes in phosphoinositide turnover could be detected when compared to control lymphocyte cultures. These data indicate that increased phosphoinositide turnover is not an absolute prerequisite for lymphocyte proliferation.
authors.affiliation: Department of Surgery, University of Miami, School of Medicine, FL 33101.
authors.forename: F J
authors.initials: FJ
authors.lastname: Hornicek
authors.forename: D H
authors.initials: DH
authors.lastname: Reese
authors.forename: H K
authors.initials: HK
authors.lastname: Lo
authors.forename: T I
authors.initials: TI
authors.lastname: Malinin
authors.forename: G I
authors.initials: GI
authors.lastname: Malinin
mesh_terms: D000818:Animals; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects*; D010504:Periodic Acid / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007376:Interleukin-2; D010716:Phosphatidylinositols; D010504:Periodic Acid