Amplification of the int-2 gene in primary human breast tumors.
Proviral activation of the int-2 gene is a frequent occurrence in mammary carcinomas induced by mouse mammary tumor virus (MMTV). Here, we have examined the human homolog of int-2 in 110 primary breast cancer DNAs. The locus was amplified 2- to 15-fold in 18 of the tumor DNA samples. Amplification of int-2 has a highly significant association (P less than 2 X 10(-6] with tumors from patients who subsequently developed a local recurrence of the disease or a distal metastasis.
Lidereau
R
R
Centre Rene Huguenin, St. Cloud, France.
Callahan
R
R
Dickson
C
C
Peters
G
G
Escot
C
C
Ali
I U
IU
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000235:genetics / Q000378:metabolism; D003001:Cloning, Molecular; D005260:Female; D005784:Gene Amplification; D006801:Humans; D051379:Mice; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000302:isolation & purification; D011519:Proto-Oncogenes; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins