title: Similar actions of kappa and mu agonists on spinal nociceptive reflexes in rats and their reversibility by naloxone.
abstract: The mu agonist fentanyl and the kappa agonists U-50,488 and tifluadom were tested intravenously in electrophysiological experiments on spinal nociceptive reflexes in anaesthetised, spinalised rats. Responses of single motoneurones to thermal and mechanical stimuli were reduced to a similar degree by both mu and kappa agonists and these effects were reversed by low doses of naloxone.
authors.affiliation: Dept. of Physiology, Medical School, Bristol, UK.
authors.forename: C G
authors.initials: CG
authors.lastname: Parsons
authors.forename: D C
authors.initials: DC
authors.lastname: West
authors.forename: P M
authors.initials: PM
authors.lastname: Headley
mesh_terms: D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology; D009270:Naloxone / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology
chemical_list: D000700:Analgesics; D011759:Pyrrolidines; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D001569:Benzodiazepines; D009270:Naloxone; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; C035470:tifluadom