title: Treatment of nonmetastatic gestational trophoblastic disease with oral methotrexate.
abstract: Fifteen patients with nonmetastatic gestational trophoblastic disease were treated solely with methotrexate given orally rather than intramuscularly. Remission, defined as a beta-human chorionic gonadotropin titer of less than 5 mIU/ml for 3 consecutive weeks, was attained in 13 (87%) of the 15 patients. Level of toxicity was acceptable. Patient comfort, convenience, and less time off work and in the physician's office are significant advantages to this efficacious, well-tolerated method of therapy.
authors.affiliation: Department of Obstetrics and Gynecology, University of Alabama Medical Center, Birmingham.
authors.forename: J F
authors.initials: JF
authors.lastname: Barter
authors.forename: S J
authors.initials: SJ
authors.lastname: Soong
authors.forename: K D
authors.initials: KD
authors.lastname: Hatch
authors.forename: J W
authors.initials: JW
authors.lastname: Orr
authors.forename: E C
authors.initials: EC
authors.lastname: Partridge
authors.forename: J M
authors.initials: JM
authors.lastname: Austin
authors.forename: H M
authors.initials: HM
authors.lastname: Shingleton
mesh_terms: D000284:Administration, Oral; D000328:Adult; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D012189:Retrospective Studies; D014328:Trophoblastic Neoplasms / Q000188:drug therapy*; D014594:Uterine Neoplasms / Q000188:drug therapy*
chemical_list: D008727:Methotrexate