title: [Inhibitory action of methysergide bimaleate on the collagenase of Clostridium histolyticum].
abstract: Inhibitory effects of methysergide bimaleate on the collagenase of the Clostridium histolyticum have been established. Having previously shown the inhibitory action of serotonin on this bacterial collagenase, the authors have tested methysergide bimaleate as another inhibitor. After injection in the peritoneum of the rats of methysergide bimaleate and collagenase together, lesions are minimal or absent, in contrast with the dramatic effects of collagenase alone. This shows the antagonist role of methysergide bimaleate in regard to collagenase and suggest that methysergide bimaleate reduce the collagenolysis and may elucidate the possible occurrence of fibrotic lesions after treatment of migraine by methysergide bimaleate in man.
authors.affiliation: Institut d'Anatomie Pathologique, Clinique Médicale A, Strasbourg.
authors.forename: A
authors.initials: A
authors.lastname: Warter
authors.forename: H
authors.initials: H
authors.lastname: Schirardin
authors.forename: J
authors.initials: J
authors.lastname: Warter
mesh_terms: D000818:Animals; D003013:Clostridium / Q000201:enzymology*; D006801:Humans; D007274:Injections, Intraperitoneal; D008784:Methysergide / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D003012:Microbial Collagenase / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D051381:Rats
chemical_list: D003012:Microbial Collagenase; D008784:Methysergide
vernacular_title: Action inhibitrice du bimaléate de méthysergide sur la collagénase du Clostridium histolyticum.