Applications of electron spin resonance spectroscopy to the identification of radicals produced during lipid peroxidation.
Electron spin resonance (ESR) spectroscopy, which is the only commonly available method for directly detecting free radicals in biological systems, has now been quite extensively used to study radicals produced by metabolism of xenobiotic chemicals and the interaction of such species with lipid molecules. This review examines a variety of different xenobiotic systems and tissues and summarises the information obtained from these studies, with particular reference to the elucidation of the nature of the radicals involved in the initiation and propagation of lipid peroxidation.
Davies
M J
MJ
Biochemistry Department, Brunel University, Uxbridge, Middlesex, U.K.
D000818:Animals; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D005609:Free Radicals; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism*; D009369:Neoplasms / Q000032:analysis; D013113:Spin Labels
D005609:Free Radicals; D008054:Lipid Peroxides; D013113:Spin Labels