[Modification by cycloheximide of the effects of insulin on the transport of calcium by sarcolemma of the myocardium].
The inhibitory effect of insulin on Ca2+-current was supposed to be due to activation of phosphoproteinphosphotases stimulated by a specific intracellular insulin messenger. The results obtained support the above suggestion. Pretreatment of myocardial preparation with cycloheximide in low concentrations completely blocks the inhibitory insulin effect on Ca2+-current due, probably, to a decrease in peptide formation. Moreover, prolonged effect of the hormone involves a considerable increase of the current as compared to its initial value. Possible mechanisms of modifying effect of cycloheximide on the function of insulin-dependent regulatory system in the myocardium, are discussed.
Nakipova
O V
OV
Kokoz
Iu M
IuM
Lazarev
A V
AV
Freĭdin
A A
AA
Krupenin
V A
VA
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003513:Cycloheximide / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007329:Insulin Antagonists / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D011895:Rana ridibunda; D012508:Sarcolemma / Q000187:drug effects* / Q000378:metabolism
D007329:Insulin Antagonists; D003513:Cycloheximide; D010749:Phosphoprotein Phosphatases; D002118:Calcium
Modifikatsiia tsiklogeksimidov éffektov insulina na transport kal'tsiia sarkolemmoĭ miokarda.