Time-dependent cGMP-activated conductance of detached patches of ROS plasma membrane.
cGMP markedly increases the cationic conductance of the 'inside-out' patches of rod outer segment plasma membrane when applied to the inner side. The cGMP-activated conductance of some patches was shown to be time-dependent. The data obtained suggest that the change of cGMP concentration in the near membrane layer underlies this phenomenon rather than the change in the channel's activity. The hydrolysis and, probably, the desorption of the nucleotide are responsible for this.
Kolesnikov
S S
SS
Institute of Biological Physics, USSR Academy of Sciences, Pushchino, Moscow Region.
Jainazarov
A B
AB
Fesenko
E E
EE
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D006152:Cyclic GMP / Q000494:pharmacology*; D004553:Electric Conductivity; D047908:Intracellular Signaling Peptides and Proteins; D008954:Models, Biological; D010786:Photoreceptor Cells / Q000502:physiology*; D011896:Rana temporaria; D012374:Rod Cell Outer Segment / Q000187:drug effects / Q000502:physiology*
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C022994:cyclic GMP-binding protein; D006152:Cyclic GMP