title: Depolarization induced by injection of cyclic nucleotides into frog taste cell.
abstract: In order to identify the intracellular transmitter involved in the taste transduction process, cyclic nucleotides were iontophoretically injected into the frog taste cells while membrane potentials were recorded intracellularly. Injection of either cyclic GMP or cyclic AMP induced a depolarization response of about 5 mV in the taste cells, but injection of Cl- had no effect. The rate of a repolarization after the depolarization elicited by cyclic GMP was larger than that after cyclic AMP. The possible role of cyclic nucleotide in the taste transduction was discussed.
authors.affiliation: Department of Physiology, Nagasaki University School of Dentistry, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
authors.forename: T
authors.initials: T
authors.lastname: Miyamoto
authors.forename: T
authors.initials: T
authors.lastname: Sato
mesh_terms: D000818:Animals; D002712:Chlorides / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology*; D006152:Cyclic GMP / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D008845:Microinjections; D011892:Rana catesbeiana; D013650:Taste Buds / Q000187:drug effects / Q000502:physiology*
chemical_list: D002712:Chlorides; D000242:Cyclic AMP; D006152:Cyclic GMP