title: [Effect of berberine on slow inward ionic current in guinea pig ventricular papillary muscle].
abstract: Using a single sucrose gap voltage clamp technique, it was found that berberine hydrochloride (Ber-HCl) had a dose-dependent biphasic effect on Isi of guinea pig papillary muscle. It was more difficult to wash out the inhibitory effect of Ber-HCl on Isi. In the initial stage of the experiment, Ber-HCl 72 mumol/L and 365 mumol/L greatly improved the influx of extracellular Ca2+ and increased the amplitude of Isi. As the drug perfusion was prolonged, however, Ber-HCl dramatically blocked Ca2+ channels and decreased the influx of extracellular Ca2+ consequently, Isi was reduced in amplitude and later disappeared. This experiment further revealed the mechanisms of action of Ber on cardiac contractility and for the treatment of arrhythmias.
authors.forename: X D
authors.initials: XD
authors.lastname: Sun
authors.forename: J M
authors.initials: JM
authors.lastname: Li
authors.forename: L J
authors.initials: LJ
authors.lastname: Tian
authors.forename: Y P
authors.initials: YP
authors.lastname: Wang
authors.forename: Y F
authors.initials: YF
authors.lastname: Yu
authors.forename: K Y
authors.initials: KY
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001599:Berberine / Q000494:pharmacology*; D001600:Berberine Alkaloids / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers; D004594:Electrophysiology; D005260:Female; D006168:Guinea Pigs; D008297:Male; D010210:Papillary Muscles / Q000187:drug effects / Q000502:physiology
chemical_list: D001600:Berberine Alkaloids; D002121:Calcium Channel Blockers; D001599:Berberine; D002118:Calcium