The N-methyl-D-aspartate (NMDA) receptor antagonist MK-801, attenuates the Bezold-Jarisch reflex in the anaesthetized rat.
The effects of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, on the Bezold-Jarisch reflex elicited by i.v. doses of 5-hydroxytryptamine (5-HT) was investigated in urethane-anaesthetized rats. Activation of the Bezold-Jarisch reflex with 5-HT (0.5-16 microgram/kg) produced pronounced dose-dependent hypotensive and bradycardic responses which were attenuated by MK-801 (1 mg/kg, i.v.) but not by saline. The data suggests that activation of the Bezold-Jarisch reflex by 5-HT involves a glutamatergic synapse presumably located within the brainstem vagal reflex arc.
Verberne
A J
AJ
University of Melbourne, Department of Medicine, Austin, Hospital, Heidelberg, Victoria, Australia.
Costa
M
M
Lewis
S J
SJ
Louis
W J
WJ
Beart
P M
PM
D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002320:Cardiovascular Physiological Phenomena; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051381:Rats; D011921:Rats, Inbred WKY; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012018:Reflex / Q000187:drug effects*; D011984:Sensory Receptor Cells / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology; D014520:Urethane
D003986:Dibenzocycloheptenes; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D012701:Serotonin; D014520:Urethane; D016291:Dizocilpine Maleate