[Catabolism of pyrimidine nucleotides in the liver of irradiated animals].
A study was made of the activity of nucleoside diphosphatase (NDPase, EC 3.6.1.16) and nucleoside triphosphatase (NTPase, EC 3.6.1.15) that catalyze enzymatic dephosphorylation of UDP, CDP, UTP, and CTP in mitochondria and postmitochondrial supernatant fraction of rat liver 30 min, 1, 3, 6 and 24 h following 60Co-gamma-irradiation with a dose of 774 mC/kg. The observed phase changes in the enzyme activity depended on the times of exposure, a cell fraction, and nucleotides under study. Both uridylic and cytidylic nucleotides exhibited a significant increase in the their enzymatic disintegration being more pronounced at a comparatively later times, that is, 6 h, and particularly, 24 h after irradiation.
Nagiev
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ER
Litovchenko
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IN
D017766:Acid Anhydride Hydrolases; D000818:Animals; D003037:Cobalt Radioisotopes; D003565:Cytidine Diphosphate; D003570:Cytidine Triphosphate; D005720:Gamma Rays; D008099:Liver / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism / Q000528:radiation effects; D043583:Nucleoside-Triphosphatase; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011742:Pyrimidine Nucleotides / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014530:Uridine Diphosphate; D014544:Uridine Triphosphate
D003037:Cobalt Radioisotopes; D011742:Pyrimidine Nucleotides; D014530:Uridine Diphosphate; D003565:Cytidine Diphosphate; D003570:Cytidine Triphosphate; D010744:Phosphoric Monoester Hydrolases; D017766:Acid Anhydride Hydrolases; D043583:Nucleoside-Triphosphatase; C023837:nucleoside-diphosphatase; D014544:Uridine Triphosphate
Issledovanie katabolizma pirimidinovykh nukleotidov v pecheni obluchennykh zhivotnykh.