[The function of the monooxygenase system of the liver in patients with psoriasis].
Liver monoxygenase system function has been examined in psoriasis patients and possible modifications of current methods of therapy analyzed with due consideration for the detected disorders. A total of 139 patients with various clinical forms of psoriasis have been examined. The function of the liver monoxygenase system has been examined with the use of antipyrine test. The studies have revealed that this system's disorders are most marked in the patients with psoriatic eruptions involving a significant area, in whom the disease runs a protracted severe course. Twenty patients with normal and impaired functions of the monoxygenase system have been administered combined treatment including zixorin (600 mg orally once a week). The results evidence that zixorin improves the therapy efficacy, particularly in the patients with depressed activity of the liver microsomal enzymes. PUVA therapy has been administered to some patients. Zixorin has alleviated the side effects of phototherapy.
Chichenina
I V
IV
D000293:Adolescent; D000328:Adult; D000983:Antipyrine; D001559:Benzhydryl Compounds / Q000627:therapeutic use; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D010105:Oxygenases / Q000096:biosynthesis / Q000097:blood*; D011701:PUVA Therapy; D011565:Psoriasis / Q000150:complications / Q000188:drug therapy / Q000201:enzymology*
D001559:Benzhydryl Compounds; D010105:Oxygenases; C016914:flumecinol; D000983:Antipyrine
K voprosu o funktsional'nom sostoianii monooksigenaznoĭ sistemy pecheni u bol'nykh psoriazom.