title: Clonidine partially blocks the physiologic effects but not the subjective effects produced by smoking marijuana in male human subjects.
abstract: Clonidine, an alpha 2-agonist, was studied in three male human subjects in a multi-dose pilot study in combination with smoking marijuana cigarettes. Marijuana alone caused increases in responses on subjective effect questionnaires and increased heart rate. Pretreatment with single oral doses of clonidine three hours prior to marijuana induced no changes in subjective effects prior to smoking marijuana and did not diminish the subjective effects produced by marijuana. Clonidine did substantially reduce but did not abolish the marijuana-induced rise in heart rate. Based on these preliminary data from three subjects, it is concluded that clonidine does not have therapeutic value in the clinical management of active marijuana abuse.
authors.affiliation: National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224.
authors.forename: E J
authors.initials: EJ
authors.lastname: Cone
authors.forename: P
authors.initials: P
authors.lastname: Welch
authors.forename: W R
authors.initials: WR
authors.lastname: Lange
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology*; D004341:Drug Evaluation; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000188:drug therapy; D008385:Marijuana Smoking / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology
chemical_list: D000324:Adrenocorticotropic Hormone; D003000:Clonidine