Chromosomal locations of the gene coding for the CD3 (T3) gamma subunit of the human and mouse CD3/T-cell antigen receptor complexes.
The gene coding for the Mr 26000 gamma chain of the human CD3 (T3) antigen/T-cell antigen receptor complex was mapped to chromosome band 11q23 by using a cDNA clone (pJ6T3 gamma-2), by in situ hybridization to metaphase chromosomes and by Southern blot analysis of a panel of human-rodent somatic cell hybrids. The mouse homolog, here termed Cdg-3, was mapped to chromosome 9 using the mouse gamma cDNA clone pB10.AT3 gamma-1 and a panel of mouse-hamster somatic cell hybrids. Similar locations for the CD3 delta genes have been described previously. Thus, the corporate results indicate that the CD3 gamma and delta genes have remained together since they duplicated about 200 million years ago.
Krissansen
G W
GW
Cell Surface Biochemistry Laboratory, Imperial Cancer Research Fund, London, United Kingdom.
Gorman
P A
PA
Kozak
C A
CA
Spurr
N K
NK
Sheer
D
D
Goodfellow
P N
PN
Crumpton
M J
MJ
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis; D004262:DNA Restriction Enzymes; D005796:Genes; D006801:Humans; D006822:Hybrid Cells / Q000166:cytology; D046911:Macromolecular Substances; D051379:Mice; D009693:Nucleic Acid Hybridization; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*
D000945:Antigens, Differentiation, T-Lymphocyte; D046911:Macromolecular Substances; D011948:Receptors, Antigen, T-Cell; D004247:DNA; D004262:DNA Restriction Enzymes