Circadian rhythm of serotonin binding in rat brain--I. Effect of the light-dark cycle.
High affinity serotonin binding to rat brain membranes showed a circadian rhythm with minimal binding at 1000 and a maximal binding at 0000. Brain serotonin levels were almost inverse to the rhythm of serotonin binding. Under reverse light-dark conditions, lights on from 1900 to 0700, a significant phase shift in serotonin binding and concentration of about 8-10 hr was found. The adaptation of the rats to the inverse light-dark cycle was ascertained by plasma ACTH and corticosterone assay.
Wesemann
W
W
Abteilung Neurochemie, Philipps-Universität, Marburg, F.R.G.
Rotsch
M
M
Schulz
E
E
Sturm
G
G
Zöfel
P
P
D000222:Adaptation, Physiological; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002940:Circadian Rhythm; D003345:Corticosterone / Q000097:blood; D003624:Darkness; D008027:Light; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone