Severe encephalopathy associated with ifosfamide administration in two children with metastatic tumors.
We studied two children with recurrent cancer, who during treatment with ifosfamide developed severe encephalopathy characterized by coma of several days duration. Ifosfamide was used as a single drug without mesna as an uroprotector. A 1-hour infusion of ifosfamide (1.8 g/m2) was given on days one and two of a planned 5-day course. Encephalopathy was associated with severe electroencephalographic abnormalities, e.g. slowing in delta range in one patient and electrographic seizures in another. Both, clinical and electroencephalographic features of encephalopathy were reversible.
Gieron
M A
MA
Department of Pediatrics, University of South Florida, Tampa.
Barak
L S
LS
Estrada
J
J
D001932:Brain Neoplasms / Q000188:drug therapy; D002675:Child, Preschool; D003128:Coma / Q000139:chemically induced*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects*; D007680:Kidney Neoplasms / Q000188:drug therapy; D008297:Male; D009447:Neuroblastoma / Q000188:drug therapy; D009396:Wilms Tumor / Q000188:drug therapy
D007069:Ifosfamide