title: Cryolumpectomy for carcinoma of the breast.
abstract: Cryosurgery and surgical en bloc excision in preventing the local recurrence of mammary adenocarcinoma were studied in BALB/cfC3H (supplied by the Cancer Research Institute, University of California Berkeley) syngeneic mice carrying virus induced mammary adenocarcinomas transplanted into the fourth mammary fat pad. Cryosurgical procedures involving multiple freeze-thaw cycles to minus 180 degrees C. followed by tumor excision substantially reduced the local recurrence rate of carcinoma of the mammary gland in the mouse. The use of cryolumpectomy in the treatment of early carcinoma of the breast in humans is presented herein.
authors.affiliation: Department of Surgery, University of California Los Angeles School of Medicine 90024.
authors.forename: R W
authors.initials: RW
authors.lastname: Rand
authors.forename: R P
authors.initials: RP
authors.lastname: Rand
authors.forename: F
authors.initials: F
authors.lastname: Eggerding
authors.forename: L
authors.initials: L
authors.lastname: DenBesten
authors.forename: W
authors.initials: W
authors.lastname: King
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000368:Aged; D000818:Animals; D001940:Breast / Q000601:surgery*; D001943:Breast Neoplasms / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000601:surgery*; D003452:Cryosurgery / Q000379:methods*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000473:pathology / Q000601:surgery*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000517:prevention & control; D011897:Random Allocation