Pharmacokinetics of a spin-labeled rubomycin analog.
Pharmacokinetics of a spin-labeled analog of rubomycin (ruboxyl) was studied. Differences were found in ruboxyl pharmacokinetics in normal and tumor-bearing animals. Most of the drug was excreted within 6 h. The differences in pharmacokinetics of ruboxyl and nitroxyl radical were established.
Konovalova
N P
NP
Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow.
Diatchkovskaya
R F
RF
Kukushkina
G V
GV
Volkova
L M
LM
Varfolomeev
V N
VN
Dombrovsky
L S
LS
Shapiro
A B
AB
D000818:Animals; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004578:Electron Spin Resonance Spectroscopy; D008099:Liver / Q000378:metabolism; D051379:Mice; D012510:Sarcoma 180 / Q000188:drug therapy / Q000378:metabolism*; D014018:Tissue Distribution
C042480:ruboxyl; D003630:Daunorubicin