Identification of erythropoietin receptors on fetal liver erythroid cells.
Erythropoietin (EPO) has a central role in the growth and development of erythroid cells. Using a biologically active radioiodinated derivative, EPO receptors were identified on fetal mouse liver cells mostly consisting of erythroid cells. 125I-EPO was cross-linked to two receptors forms with apparent molecular masses of 110 and 95 kilodaltons, respectively and both having similar affinity toward EPO.
Tojo
A
A
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Fukamachi
H
H
Kasuga
M
M
Urabe
A
A
Takaku
F
F
D000818:Animals; D002478:Cells, Cultured; D004921:Erythropoietin / Q000378:metabolism*; D005333:Fetus; D007700:Kinetics; D008099:Liver / Q000196:embryology / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR; D008970:Molecular Weight; D011956:Receptors, Cell Surface / Q000302:isolation & purification / Q000378:metabolism*; D017467:Receptors, Erythropoietin
D011956:Receptors, Cell Surface; D017467:Receptors, Erythropoietin; D004921:Erythropoietin