[Combined effect of cytomegalovirus infection and allo-immunization on the cytotoxic T lymphocyte response in the mouse].
We have investigated the reciprocal influence of CMV infection and allo-immunisation on the CTL response of mice against allogeneic cells and TNP modified syngeneic cells. The data show that allo-immunisation regulates the immunological modifications brought about by CMV infection; allo-immunisation impedes the increased reactivity induced by CMV and counters the suppression induced by CMV when the mice are tested against a non specific target, whereas CMV induced immunosuppression persists against the specific immunizing antigen. Reciprocally CMV infection modulates the effect of all-immunisation: whatever may be the effect of CMV infection, the allo-suppression persists against the specific target, whereas it is abolished against a non specific one. We conclude that there is an immune interaction between CMV infection and allo-immunisation which might have clinical implications.
Lang
P
P
INSERM U 139, Hôpital Henri-Mondor, Créteil.
Shearer
G
G
D000818:Animals; D003586:Cytomegalovirus Infections / Q000276:immunology*; D007108:Immune Tolerance; D007111:Immunity, Cellular / Q000187:drug effects; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D007519:Isoantigens / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D007519:Isoantigens
Effet combiné de l'infection à cytomégalovirus et de l'allo-immunisation sur la réponse T cytotoxique de la souris.