title: Conservative surgery with radiation therapy in clinical stage I and II breast cancer. Results of a 20-year experience.
abstract: Conservative surgery and radiation therapy have been increasingly utilized at Yale-New Haven (Conn) Hospital since the 1960s. This analysis represents our experience from 1962 to 1982, with a total of 281 patients having a minimum assessable follow-up of five years and a median follow-up of 7.4 years. Five- and ten-year actuarial survivals were 83% and 67%, respectively. The actuarial breast recurrence-free rate was 91% at five years and 80% at ten years. Of 31 patients having recurrences in the breast alone, the actuarial five-year survival following recurrence was 48%. Twenty-eight (90%) of these 31 recurrences were salvageable with mastectomy or repeated wedge resection. Patients experiencing an early breast recurrence (less than three years) following initial treatment had a poorer prognosis than patients having recurrences later.
authors.affiliation: Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510.
authors.forename: B G
authors.initials: BG
authors.lastname: Haffty
authors.forename: N B
authors.initials: NB
authors.lastname: Goldberg
authors.forename: M
authors.initials: M
authors.lastname: Rose
authors.forename: B
authors.initials: B
authors.lastname: Heil
authors.forename: D
authors.initials: D
authors.lastname: Fischer
authors.forename: M
authors.initials: M
authors.lastname: Beinfield
authors.forename: C
authors.initials: C
authors.lastname: McKhann
authors.forename: J B
authors.initials: JB
authors.lastname: Weissberg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008327:Mammography; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000628:therapy; D009367:Neoplasm Staging; D010808:Physical Examination; D012086:Reoperation