[Changes in serum hormone and peptide levels in rats in experimental epilepsy].
Serum levels of 7 hormones and neuropeptides were studied in the course of development of a generalized epileptic activity (EA) induced in rats by intraperitoneal administration of corasole (75 mg/kg), i.e. 30 s (latent period), 50-150 s, 5-10 min after epileptogenic administration. A significant increase in the levels of ACTH (5.2-fold), glucagon (1.8.-fold), angiotensin I and renin activity were shown to occur 90-180 s later. Further on in the course of EA the level of ACTH remained enhanced but the level of glucagon and renin-angiotensin activity returned to normal. The levels of cortisol, vasopressin and aldosterone were enhanced 2-3-fold 30 min later. The level of insulin 30 min later remained unchanged. The role of neuropeptides and hormones in the onset and suppression of EA is discussed.
Goriacheva
T V
TV
Glebov
R N
RN
Mikhal'skaia
I T
IT
D000305:Adrenal Cortex Hormones / Q000097:blood*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000450:Aldosterone / Q000097:blood; D000803:Angiotensin I / Q000097:blood; D000818:Animals; D004827:Epilepsy / Q000097:blood* / Q000209:etiology; D005934:Glucagon / Q000097:blood; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D009479:Neuropeptides / Q000097:blood*; D051381:Rats; D012083:Renin / Q000097:blood*; D014667:Vasopressins / Q000097:blood
D000305:Adrenal Cortex Hormones; D009479:Neuropeptides; D014667:Vasopressins; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D005934:Glucagon; D000803:Angiotensin I; D012083:Renin; D006854:Hydrocortisone
Izmenenie soderzhaniia gormonov i peptidov v plazme krovi krys pri éksperimental'noĭ épilepsii.