title: Functional atrophy of brown adipose tissue during lactation in mice. Effects of lactation and weaning on mitochondrial GDP binding and uncoupling protein.
abstract: The thermogenic activity and capacity of brown adipose tissue were determined in mice during lactation and after weaning. There was a marked fall during lactation in the mitochondrial content of the tissue, and in GDP binding and the specific mitochondrial concentration of uncoupling protein. The lactation-induced functional atrophy of brown adipose tissue was fully reversible after weaning; mitochondrial content and the mitochondrial concentration of uncoupling protein were both restored, although GDP binding was not normalized.
authors.affiliation: Dunn Nutrition Laboratory, Medical Research Council, Cambridge, U.K.
authors.forename: P
authors.initials: P
authors.lastname: Trayhurn
authors.forename: G
authors.initials: G
authors.lastname: Jennings
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001284:Atrophy / Q000378:metabolism; D002352:Carrier Proteins; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D006153:Guanosine Diphosphate / Q000378:metabolism; D007473:Ion Channels; D007774:Lactation / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins; D009929:Organ Size; D011247:Pregnancy; D011506:Proteins / Q000378:metabolism; D000071256:Uncoupling Protein 1
chemical_list: D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D011506:Proteins; D000071256:Uncoupling Protein 1; D006153:Guanosine Diphosphate; D003576:Electron Transport Complex IV