title: [Effect of actoprotectors on Ca, Mg-dependent ATPase activity in the sarcoplasmatic reticulum of rabbit muscles].
abstract: The effect of different chemical compounds on Ca, Mg-dependent ATPase (Ca-ATPase) sarcoplasmic reticulum (SR) hydrolytic activity as well as their actoprotecting (AP) activity, the ability to increase organism's resistance under muscle stress and antihypoxanthic (AH) activity to increase the organism's survival under conditions of low pressure has been studied. The compounds with AP-activity have been shown to be strong inhibitors of Ca-ATPase SR hydrolytic activity. No correlation between AP-activity of the compounds and their effect on Ca-ATPase SR has been found. The membranotropic activity of actoprotectors has been shown by electronic paramagnetic resonance method. A suggestion has been made to use Ca-ATPase SR as a tested object during the forecasting actoprotecting activity of new chemical compounds.
authors.forename: E Ia
authors.initials: EIa
authors.lastname: Kaplan
authors.forename: A V
authors.initials: AV
authors.lastname: Limantsev
authors.forename: Iu Sh
authors.initials: IuSh
authors.lastname: Moshkovskiĭ
authors.forename: L L
authors.initials: LL
authors.lastname: Palkin
authors.forename: L V
authors.initials: LV
authors.lastname: Tat'ianenko
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000037:antagonists & inhibitors*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D004578:Electron Spin Resonance Spectroscopy; D000860:Hypoxia / Q000517:prevention & control*; D066298:In Vitro Techniques; D011817:Rabbits; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000201:enzymology*; D013329:Structure-Activity Relationship
chemical_list: D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases
vernacular_title: Vliianie aktoprotektorov na aktivnost' Ca, Mg-zavisimoĭ ATFazy sarkoplazmaticheskogo retikuluma iz myshts krolika.