(+)-Curcuphenol and dehydrocurcuphenol, novel sesquiterpenes which inhibit H,K-ATPase, from a marine sponge Epipolasis sp.
Two H,K-ATPase inhibitors and an inactive related compound have been isolated from a marine sponge Epipolasis sp. They are aromatic sesquiterpene alpha-curcumenes.
Fusetani
N
N
Laboratory of Marine Biochemistry, Faculty of Agriculture, University of Tokyo, Japan.
Sugano
M
M
Matsunaga
S
S
Hashimoto
K
K
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects; D017506:H(+)-K(+)-Exchanging ATPase; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000032:analysis*; D051381:Rats; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D013270:Stomach / Q000201:enzymology
D012717:Sesquiterpenes; C054390:8,9-dehydrocurcuphenol; C054389:curcuphenol; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase