Comparative physical dependence studies in rats with flupirtine and opiate receptor stimulating analgesics.
In physical dependence studies in rats the principle criterion was loss of body weight after withdrawal of the dependence producing drug. Other typical signs of withdrawal were also observed. In contrast to buprenorphine, codeine and tramadol, flupirtine caused no decrease in body weight and no other withdrawal symptoms. Flupirtine does not produce opiate type physical dependence.
Nickel
B
B
Biological Research Pharmacology, Homburg Degussa Pharma Gruppe, Frankfurt, Federal Republic of Germany.
Aledter
A
A
D000631:Aminopyridines / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002047:Buprenorphine / Q000494:pharmacology; D003061:Codeine / Q000494:pharmacology; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects; D019966:Substance-Related Disorders; D014147:Tramadol / Q000494:pharmacology
D000631:Aminopyridines; D000700:Analgesics; D011957:Receptors, Opioid; D014147:Tramadol; D002047:Buprenorphine; C034161:flupirtine; D003061:Codeine