[Cytogenetic activity of chemical compounds in adrenalectomized animals].
Pyrimethamine, sodium salicylate or ethanol were administered to adrenalectomized rats 3 and 21 days after the operation. It is shown that cytogenetic effect in the operated rats is less pronounced, particularly 3 weeks after the operation. Adrenaline (0.2 mg/kg) increases the effect of chemicals on the chromosome apparatus, while hydrocortisone (50 mg/kg) and corticotropin (10 U/kg) decrease it.
Variliak
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IR
Saglo
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D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D002869:Chromosome Aberrations; D004837:Epinephrine / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D009153:Mutagens / Q000494:pharmacology*; D011739:Pyrimethamine / Q000494:pharmacology; D051381:Rats; D012980:Sodium Salicylate / Q000494:pharmacology
D009153:Mutagens; D000431:Ethanol; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone; D012980:Sodium Salicylate; D004837:Epinephrine; D011739:Pyrimethamine
Tsitogeneticheskaia aktivnost' nekotorykh khimicheskikh soedineniĭ u adrenaléktomirovannykh zhivotnykh.