Effect of chronic exercise on beta-endorphin receptor levels in rats.
A radioreceptor assay using [3H]2-beta-endorphin (B-EP) was used to examine binding in the brains of rats that had been exercised on a treadmill for 5 months. The binding of [3H]2-beta-EP to brain homogenates gave an average Kd of 0.830 +/- 0.055 nM for the controls and 0.826 + 0.022 nM for the runners, and respective Bmax's of 166 +/- 20 pM and 159 +/- 27 pM.
Houghten
R A
RA
Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.
Pratt
S M
SM
Young
E A
EA
Brown
H
H
Spann
D R
DR
D000818:Animals; D001921:Brain / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D005082:Physical Exertion; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D011957:Receptors, Opioid / Q000378:metabolism*; D001615:beta-Endorphin / Q000378:metabolism*
D011957:Receptors, Opioid; D001615:beta-Endorphin