[Protein level and Na,K-ATPase activity of rat kidney tissues following cis-platin administration].
Concentrations of protein and electrolytes as well as activity of Na,K-ATPase were studied in renal tissue of rats within 5 days after cisplatinum administration (5 mg/kg of body mass, intraperitoneally). There were a significant reduction in the ATPase activity and an increase in water content and sodium concentration in renal cortex tissue, while K+, Ca2+ and Mg2+ were unaltered. At the same time, concentration of electrolytes did not shift in blood serum and muscle tissue. After intraperitoneal administration of choline chloride at a dose of 290 mg/kg of body mass within 40 min before the cisplatinum treatment less distinct alterations were observed in the urea content and in the Na,K-ATPase activity.
Reznik
L V
LV
Miazina
E M
EM
Natochin
Iu V
IuV
D000818:Animals; D002945:Cisplatin / Q000633:toxicity*; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D007677:Kidney Function Tests; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
D000254:Sodium-Potassium-Exchanging ATPase; D002945:Cisplatin
Soderzhanie belka i aktivnost' Na,K-ATFazy v tkaniakh pochki krys pri deĭstvii tsis-platiny.