Central inhibitory control of sodium appetite in rats: correlation with pituitary oxytocin secretion.
In the present experiments we examined neurohypophyseal hormone secretion in various models of sodium appetite in rats. Basal plasma levels of oxytocin were found to be low in sodium-deficient adrenalectomized rats and in intact animals treated daily with desoxycorticosterone acetate, both of which groups drank large amounts of NaCl solution, whereas basal plasma levels of arginine vasopressin were neither stimulated nor suppressed. Conversely, sodium appetite consistently was inhibited by treatments that stimulated pituitary oxytocin secretion. However, sodium appetite was not inhibited by administration of exogenous oxytocin, nor was it stimulated by administration of an oxytocin receptor antagonist. These and other results suggest that sodium appetite may be inhibited by activity in the supraoptic and/or paraventricular nuclei, the location of the neurons responsible for the synthesis of oxytocin, and can be stimulated only when activity in those neurons is reduced. Whatever the final neural pathway, our data support the hypothesis that the control of sodium appetite is governed by inhibitory as well as excitatory central mechanisms.
Stricker
E M
EM
Department of Behavioral Neuroscience, University of Pittsburgh, Pennsylvania 15260.
Verbalis
J G
JG
D000311:Adrenal Glands / Q000502:physiology; D000818:Animals; D001066:Appetite / Q000502:physiology*; D001127:Arginine Vasopressin / Q000097:blood; D008297:Male; D009433:Neural Inhibition; D010121:Oxytocin / Q000097:blood*; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology; D010904:Pituitary Gland, Posterior / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011945:Receptors, Angiotensin / Q000502:physiology; D018045:Receptors, Oxytocin; D012965:Sodium Chloride / Q000008:administration & dosage*; D013495:Supraoptic Nucleus / Q000502:physiology; D014882:Water-Electrolyte Balance
D011945:Receptors, Angiotensin; D018045:Receptors, Oxytocin; D001127:Arginine Vasopressin; D012965:Sodium Chloride; D010121:Oxytocin