[The role of calcium homeostasis hormones in the development of tolerance following drug and alcohol consumption].
The present experiments were performed in order to assess the effects of cocaine and ethanol on the calcitonin and parathyroid hormone present in the cerebrospinal fluid and plasma of sheep in vivo. Cocaine or ethanol were i.a. administered daily up to 20 days to sheep. Blood and CSF were obtained simultaneously at 1 hour intervals. CSF and plasma CT and PTH were measured by radioimmunoassay. Blood alcohol concentrations were determined by GC. The results indicated that cocaine and ethanol administrations were followed by increase of both PTH and CT in plasma and CSF. However, this effects are present only up to 10 days. Later the concentrations of CT and PTH remained unchanged. This indicated the development of physical tolerance.
Balabanova
S
S
Nowak
R
R
Reinhardt
G
G
D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D002116:Calcitonin / Q000502:physiology*; D002118:Calcium / Q000097:blood; D003042:Cocaine; D004361:Drug Tolerance; D006706:Homeostasis / Q000187:drug effects; D008297:Male; D010281:Parathyroid Hormone / Q000502:physiology*; D012756:Sheep; D019966:Substance-Related Disorders / Q000503:physiopathology*
D010281:Parathyroid Hormone; D002116:Calcitonin; D003042:Cocaine; D002118:Calcium
Die Rolle der Calcium-Homöostase-Hormone bei der Toleranzentwicklung nach Drogen- und Alkoholkonsum.