title: Role of inositol trisphosphate as a second messenger in signal transduction processes: an essay.
abstract: This essay attempts to summarize some of the best evidence for the role of inositol trisphosphate as a second messenger in signal transduction processes. The following aspects are addressed in the essay: (a) The synthesis of inositol trisphosphate and other inositol lipids, (b) Receptor-phosphatidylinositol bisphosphate phospholipase C coupling and the N-ras protooncogene, (c) Inositol trisphosphate and intracellular calcium, (d) Cell growth and oncogenes, (e) Receptors linked to the phosphatidylinositol cycle, (f) Phototransduction and (g) Interactions between inositol trisphosphate and other second messengers.
authors.affiliation: Nuffield Laboratory of Ophthalmology, University of Oxford, U.K.
authors.forename: N N
authors.initials: NN
authors.lastname: Osborne
authors.forename: A B
authors.initials: AB
authors.lastname: Tobin
authors.forename: H
authors.initials: H
authors.lastname: Ghazi
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology; D004075:Diglycerides; D015544:Inositol 1,4,5-Trisphosphate; D007295:Inositol Phosphates / Q000378:metabolism / Q000502:physiology*; D009857:Oncogenes; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols / Q000378:metabolism / Q000502:physiology*; D010775:Photic Stimulation; D010786:Photoreceptor Cells / Q000378:metabolism / Q000502:physiology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism / Q000502:physiology; D011956:Receptors, Cell Surface / Q000378:metabolism / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear; D011976:Receptors, Muscarinic / Q000378:metabolism / Q000502:physiology; D013403:Sugar Phosphates / Q000502:physiology*; D010738:Type C Phospholipases / Q000378:metabolism / Q000502:physiology*
chemical_list: D004075:Diglycerides; D007295:Inositol Phosphates; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols; D011942:Receptors, Adrenergic, alpha; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D011976:Receptors, Muscarinic; D013403:Sugar Phosphates; C040985:phosphatidylinositol receptors; D015544:Inositol 1,4,5-Trisphosphate; D010738:Type C Phospholipases; D002118:Calcium