Enantioselective disposition of R-(-)- and S-(+)-prenylamine in the rat.
The disposition of R- and S-prenylamine was investigated in male Wistar rats after i.v. and p.o. dosage of 2 mg/kg racemic prenylamine. Concentrations of the enantiomers were determined in plasma, lung, heart, spleen, liver kidney and muscle tissue within a period of 5 h after dosage. In addition, plasma protein binding was assayed in vitro with racemic drug and found to be similar for the two enantiomers. Except for plasma samples after i.v. administration the concentrations of the S-enantiomer exceeded those of the R-enantiomer.
Gietl
Y
Y
Department of Pharmacology, Johann Wolfgang Goethe-University, Frankfurt/Main, Fed. Rep. of Germany.
Spahn
H
H
Mutschler
E
E
D000284:Administration, Oral; D000818:Animals; D008297:Male; D011299:Prenylamine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D014018:Tissue Distribution
D011299:Prenylamine