title: Demonstration of beta-adrenergic receptors in rat nasal glands by an in vitro autoradiographic technique.
abstract: The distribution of beta-adrenergic receptors in rat nasal glands has been investigated with the use of an in vitro autoradiographic technique. Radioligand binding studies indicated that [125I]cyanopindolol binds specifically to beta-adrenergic receptors in cryostat sections of these glands. Autoradiograms generated after incubation with 0.02 nM [125I]cyanopindolol and dipping in nuclear K2 emulsion, showed specific labelling of the striated excretory ducts. These in vitro observations suggest a sympathetic control of the ion and water content of the glandular secretion.
authors.affiliation: Department of Otorhinolaryngology, University of Nijmegen, The Netherlands.
authors.forename: Y J
authors.initials: YJ
authors.lastname: van Megen
authors.forename: C J
authors.initials: CJ
authors.lastname: van Ratingen
authors.forename: A B
authors.initials: AB
authors.lastname: Klaassen
authors.forename: J F
authors.initials: JF
authors.lastname: Rodrigues de Miranda
authors.forename: C A
authors.initials: CA
authors.lastname: van Ginneken
authors.forename: P
authors.initials: P
authors.lastname: van den Broek
mesh_terms: D000320:Adrenergic Fibers / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography / Q000379:methods*; D066298:In Vitro Techniques; D009297:Nasal Mucosa / Q000294:innervation*; D010869:Pindolol / Q000031:analogs & derivatives* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
chemical_list: D011943:Receptors, Adrenergic, beta; C047975:cyanopindolol; D010869:Pindolol