Polymorphonuclear leucocyte function and previous yersinia arthritis: correlation of enhanced superoxide production with late manifestations.
Polymorphonuclear leucocyte (PMN) functions (migration in vitro, chemiluminescence, O-2 production, and aggregation) were studied in 32 patients with previous yersinia arthritis (YA). PMNs of 11 HLA-B27 positive patients who had chronic or recurrent inflammatory symptoms showed O-2 production significantly higher than that of PMNs of 11 HLA-B27 positive patients without late manifestations. Also, PMNs of both HLA-B27 positive and negative patients tended to show chemotactic and chemokinetic migration rates higher than those of control cells of healthy HLA-B27 negative subjects. These functional aberrations may play a part in the development of the patients' inflammatory symptoms.
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Department of Bacteriology and Immunology, University of Helsinki, Finland.
Koivuranta-Vaara
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Leirisalo-Repo
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D000328:Adult; D001170:Arthritis, Infectious / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D002634:Chemotaxis, Leukocyte; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D013481:Superoxides / Q000378:metabolism*; D015009:Yersinia Infections / Q000150:complications / Q000276:immunology* / Q000378:metabolism
D006680:HLA Antigens; D015796:HLA-B27 Antigen; D013481:Superoxides