title: ATP-gamma-S (adenosine 5'-O-(3-thiotriphosphate)) microinjection increases progesterone-stimulated histone kinase activity in Xenopus oocytes.
abstract: Progesterone stimulates the activity of a potent Ca2+- and cyclic nucleotide-independent histone kinase in Xenopus oocytes. Microinjection of ATP-gamma-S during the course of meiotic maturation or after the oocytes had arrested at second meiotic metaphase resulted in a further increase of this histone kinase activity in progesterone-stimulated oocytes. ATP-gamma-S microinjection also increased and stabilized the activity of the maturation-promoting factor. The possible mechanism of ATP-gamma-S action is discussed.
authors.affiliation: INSERM U.249 and CNRS-CRBM, Montpellier, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Labbé
authors.forename: A
authors.initials: A
authors.lastname: Picard
authors.forename: M
authors.initials: M
authors.lastname: Dorée
mesh_terms: D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D000345:Affinity Labels / Q000494:pharmacology*; D000818:Animals; D004789:Enzyme Activation; D005260:Female; D006133:Growth Substances / Q000378:metabolism*; D016200:Maturation-Promoting Factor; D008845:Microinjections; D009865:Oocytes / Q000201:enzymology*; D010766:Phosphorylation; D011374:Progesterone / Q000494:pharmacology*; D006656:Protamine Kinase / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D014981:Xenopus
chemical_list: D000345:Affinity Labels; D006133:Growth Substances; C022571:adenosine 5'-O-(3-thiotriphosphate); D011374:Progesterone; D000255:Adenosine Triphosphate; D011494:Protein Kinases; D006656:Protamine Kinase; D016200:Maturation-Promoting Factor