title: Osmolality-regulated arginine vasopressin release in conscious dogs. Evidence for dopaminergic or opioid modulation?
abstract: Experiments were performed in conscious dogs, in order to study the possibility of dopaminergic or opioid modulation of the osmolality-regulated release of AVP. Hypertonic saline (20%), infused during a period of 2 h at a rate of 0.03 ml.kg-1.min-1, induced a significant AVP response, which was not influenced by prior administration of bromocriptine or naloxone. Data presented in this report, therefore, are not in support of a dopaminergic or opioid modulation of the osmolality-regulated AVP release in dogs. The results demonstrate a great consistency in individual plasma osmolality-plasma AVP relationships, next to a large inter-individual variation.
authors.affiliation: Subdepartment of Veterinary Anesthesia, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
authors.forename: L J
authors.initials: LJ
authors.lastname: Hellebrekers
authors.forename: E
authors.initials: E
authors.lastname: Lagerweij
authors.forename: H W
authors.initials: HW
authors.lastname: de Vries
authors.forename: T B
authors.initials: TB
authors.lastname: Van Wimersma Greidanus
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D005260:Female; D008297:Male; D009994:Osmolar Concentration; D011954:Receptors, Dopamine / Q000502:physiology*; D011957:Receptors, Opioid / Q000502:physiology*; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D012964:Sodium / Q000097:blood
chemical_list: D011954:Receptors, Dopamine; D011957:Receptors, Opioid; D012462:Saline Solution, Hypertonic; D001127:Arginine Vasopressin; D012964:Sodium