A residual mature teratoma with a more balanced karyotype than the primary testicular nonseminoma?
We have been able to study the karyotypes and measure the DNA content in both the primary nonseminomatous germ cell tumor of the testes and the residual mature teratoma after chemotherapy of the same patient. Based on these and other studies, the mechanism of therapy-related differentiation in germ cell tumors of the testes is discussed.
Castedo
S M
SM
Department of Human Genetics, University of Groningen, The Netherlands.
Oosterhuis
J W
JW
de Jong
B
B
Seruca
R
R
Dam
A
A
Buist
J
J
Schraffordt Koops
H
H
Sleijfer
D T
DT
D000328:Adult; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000032:analysis; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D012186:Retroperitoneal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000556:secondary; D013724:Teratoma / Q000235:genetics* / Q000473:pathology / Q000556:secondary; D013736:Testicular Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy
D004273:DNA, Neoplasm; D005819:Genetic Markers