A retrovirus carrying the polyomavirus middle T gene induces acute thrombocythemic myeloproliferative disease in mice.
Mice inoculated with an artificially constructed retrovirus carrying the middle T gene of polyomavirus develop acute myeloproliferative disease with severe thrombotic and hemorrhagic disorder and impaired platelet function. The megakaryocytic lineage appears to be a target for polyoma-murine leukemia virus infection and middle T gene expression. This newly described disease represents a unique model system for studying disorders of the megakaryocytic lineage.
Fusco
A
A
Centro di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy.
Portella
G
G
Grieco
M
M
Tajana
G
G
Di Minno
G
G
Polli
N
N
Pinto
A
A
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000957:Antigens, Viral, Tumor / Q000235:genetics*; D000001:Calcimycin / Q000494:pharmacology; D004274:DNA, Recombinant; D009052:Leukemia Virus, Murine / Q000235:genetics / Q000472:pathogenicity*; D051379:Mice; D009196:Myeloproliferative Disorders / Q000382:microbiology* / Q000473:pathology; D010974:Platelet Aggregation; D011120:Polyomavirus / Q000472:pathogenicity*; D013920:Thrombocythemia, Essential / Q000382:microbiology* / Q000473:pathology
D000957:Antigens, Viral, Tumor; D004274:DNA, Recombinant; D000001:Calcimycin; D000255:Adenosine Triphosphate