title: Interleukin-6 is produced by bone and modulated by parathyroid hormone.
abstract: Interleukin-6 (IL-6) is a cellular regulatory molecule, the diverse functions of which relate to cells both within and outside the immune system. In this report we demonstrated that bone tissue, specifically osteoblasts, produce interleukin-6 and that this function can be modulated by the osteotrophic hormone parathyroid hormone (PTH). Given that the complex process of bone remodeling is now thought to be regulated not only by systemic hormones but also by locally produced factors, the existence of a parathyroid hormone-stimulated production of interleukin-6 by osteoblasts may have important physiological significance.
authors.affiliation: Preclinical Research, Sandoz AG, Basel, Switzerland.
authors.forename: J H
authors.initials: JH
authors.lastname: Feyen
authors.forename: P
authors.initials: P
authors.lastname: Elford
authors.forename: F E
authors.initials: FE
authors.lastname: Di Padova
authors.forename: U
authors.initials: U
authors.lastname: Trechsel
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D001842:Bone and Bones / Q000378:metabolism*; D002116:Calcitonin / Q000494:pharmacology; D002455:Cell Division; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology; D006801:Humans; D006825:Hybridomas; D007375:Interleukin-1 / Q000494:pharmacology; D015850:Interleukin-6 / Q000378:metabolism*; D007700:Kinetics; D051379:Mice; D010006:Osteoblasts / Q000378:metabolism*; D012516:Osteosarcoma / Q000378:metabolism; D010281:Parathyroid Hormone / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000911:Antibodies, Monoclonal; D007375:Interleukin-1; D015850:Interleukin-6; D010281:Parathyroid Hormone; D003907:Dexamethasone; D002116:Calcitonin; D013755:Tetradecanoylphorbol Acetate