Monoclonal antibody--defined lymphocyte subsets in normal Nigerians.
Lymphocyte subsets using monoclonal antibodies have hitherto not been reported in normal Nigerian subjects. In all 8 subjects, the average number of lymphocytes showed a clear rhythmicity with higher values in the morning (8 AM) than in the afternoon (2 PM). The time of day variation in circulating lymphocytes appears to affect T cells rather than B cells. The absolute numbers of OKT4+ cells at 8 AM was significantly higher than at 2 PM (p less than 0.05). It would appear that the OKT4+ cells are largely responsible for the time of day variation in peripheral blood lymphocytes, owing probably to a greater sensitivity to changes in plasma cortisol levels.
Adedeji
M O
MO
Department of Hematology, College of Medical Sciences, University of Benin, Nigeria.
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis*; D002940:Circadian Rhythm; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D008297:Male; D009549:Nigeria; D012016:Reference Values
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation