title: Enhanced transbilayer mobility of phospholipids in malaria-infected monkey erythrocytes: a spin-label study.
abstract: Using a recently described technique of electron spin resonance spectroscopy, we determined the rate of transbilayer mobility (flip) of the four major simian-erythrocyte phospholipids in the erythrocyte membrane after infection by Plasmodium knowlesi. The development of the malarial parasite induces a very large increase in the flip rate of these phospholipids (mainly during the ring stage and at the beginning of trophozoite maturation). The half flip time fell from 2 and 3 hr in the case of choline phospholipids in healthy erythrocytes to less than 15 min in erythrocytes infected with the last stage of the parasite.
authors.affiliation: UA 530 CNRS, INSERM U 58, Montpellier, France.
authors.forename: B D
authors.initials: BD
authors.lastname: Beaumelle
authors.forename: H J
authors.initials: HJ
authors.lastname: Vial
authors.forename: A
authors.initials: A
authors.lastname: Bienvenüe
mesh_terms: D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology* / Q000648:ultrastructure; D008051:Lipid Bilayers; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008288:Malaria / Q000097:blood*; D008855:Microscopy, Electron, Scanning; D010743:Phospholipids / Q000097:blood*; D010961:Plasmodium / Q000254:growth & development
chemical_list: D008051:Lipid Bilayers; D010743:Phospholipids