Epstein-Barr-virus-related malignant B cell lymphoplasmacytic lymphoma following allogeneic bone marrow transplantation for aplastic anemia.
The development of B cell lymphoma has been reported to occur in recipients of a variety of organ transplants, including some patients who have received an allogeneic bone marrow graft. In this report, we describe a patient with severe aplastic anemia who developed a malignant B cell lymphoplasmacytoid proliferation 48 days after undergoing allogeneic marrow transplantation from her HLA-matched MLC-nonreactive brother. Immunologic studies showed this malignancy to be a mixed polyclonal and monoclonal proliferation in donor cells. Virologic studies documented Epstein Barr infection of the cells. A review of the literature suggests that graft-versus-host disease and treatment of this complication by antithymocyte globulin are related to the development of the EBV-related malignancy in the EBV-infected B cells of the developing bone marrow graft.
Forman
S J
SJ
Sullivan
J L
JL
Wright
C
C
Ratech
H
H
Racklin
B
B
Blume
K G
KG
D000328:Adult; D000741:Anemia, Aplastic / Q000150:complications*; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000276:immunology; D001402:B-Lymphocytes / Q000473:pathology; D016026:Bone Marrow Transplantation; D002213:Capsid / Q000276:immunology; D019309:Epstein-Barr Virus Nuclear Antigens; D005260:Female; D005796:Genes; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D008223:Lymphoma / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D019309:Epstein-Barr Virus Nuclear Antigens; D007145:Immunoglobulin kappa-Chains