Premarin priming before prednimustine, high-dose folinic acid and 5-fluorouracil as salvage chemotherapy for advanced breast cancer.
Thirty patients with advanced and mainly pretreated breast cancer were treated with a combination of premarin, prednimustine, high-dose folinic acid and 5-fluorouracil. Among the 30 evaluable patients, 9 (30%) achieved an objective response (median duration: 9 months). Oral mucositis was the limiting toxicity, while myelosuppression was quite mild. In spite of considerable activity as salvage regimen, these results do not seem better than those achieved in our Institute with high-dose folinic acid and 5-fluorouracil alone.
Marini
G
G
Servizio di Oncologia, Fondazione Beretta, Spedali Civili, Brescia, Italy.
Simoncini
E
E
Marpicati
P
P
Montini
E
E
Ferrari
V
V
Arcangeli
G
G
Zaniboni
A
A
D001943:Breast Neoplasms / Q000188:drug therapy; D002699:Chlorambucil / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use*; D011238:Prednimustine / Q000627:therapeutic use*
D004966:Estrogens, Conjugated (USP); D002699:Chlorambucil; D011238:Prednimustine; D002955:Leucovorin; D005472:Fluorouracil