Chromosomal localization of the gene for a human thyroid hormone-binding protein.
A cDNA for the gene that encodes for a human cellular thyroid hormone-binding protein (p55) has recently been isolated and sequenced. The sequence of p55 indicates that it is identical to the protein disulfide isomerase and the beta-subunit of prolyl 4-hydroxylase. By in situ hybridization, the gene for p55 was localized on chromosome 17 at band q25. This localization shows that the p55 gene is not linked to either erbA1 or erbA2; two other thyroid hormone-binding protein genes are located at 17q 11-21 and 3p21-pter, respectively. The localization of p55 gene will permit the evaluation of the possible effects of chromosome changes on the structure and activity of the p55 gene in chromosome syndromes or neoplasms.
Popescu
N C
NC
Laboratory of Biology, National Cancer Institute, Bethesda, MD 20892.
Cheng
S Y
SY
Pastan
I
I
D002352:Carrier Proteins / Q000235:genetics*; D002478:Cells, Cultured; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D005796:Genes; D006801:Humans; D007535:Isomerases / Q000235:genetics; D007621:Karyotyping; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics*; D008677:Metaphase; D009693:Nucleic Acid Hybridization; D011393:Procollagen-Proline Dioxygenase / Q000235:genetics; D019704:Protein Disulfide-Isomerases; D013963:Thyroid Hormones; D000097810:Thyroid Hormone-Binding Proteins
D002352:Carrier Proteins; D007535:Isomerases; D008565:Membrane Proteins; D011393:Procollagen-Proline Dioxygenase; D019704:Protein Disulfide-Isomerases; D013963:Thyroid Hormones; D000097810:Thyroid Hormone-Binding Proteins