Role of cyclic AMP in the action of dopaminergic D2 receptors of some endocrine glands in rats.
Short-term and long-term effects of bromocriptine mesylate (10 mg/kg i.p.) on cyclic AMP contents of the liver and some endocrine glands have been investigated in the presence and absence of sulpiride (10 mg/kg i.p.). Results revealed that bromocriptine caused significant elevations in the cyclic AMP contents of the liver and reduction in its adrenocortical content. Bromocriptine effect on the adrenal cortex was antagonized by sulpiride, whereas its effect on the liver was not changed. Bromocriptine did not change the cyclic AMP content in the thyroid gland or the ovary.
Abu-Jayyab
A
A
College of Pharmacy, Department of Pharmacology, King Saud University, Riyadh, Saudi Arabia.
el-Denshary
E E
EE
Ageel
A M
AM
Dakkak
M R
MR
D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D004347:Drug Interactions; D004702:Endocrine Glands / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*; D017448:Receptors, Dopamine D2; D013469:Sulpiride / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D001971:Bromocriptine; D013469:Sulpiride; D000242:Cyclic AMP