[Effect of guar on plasma lipids and on the biological activity of insulin in patients with type 2 diabetes mellitus].
10 patients with type 2 diabetes mellitus, in stable weight and diet therapy, followed a 2 months nutritional supplementation with guar, 15 g/day. Their previous nutritional and pharmacological therapy was not modified throughout the study. No changes occurred in body weight or major parameters of metabolic control. However, a significant fall occurred in fasting plasma, total and LDL cholesterol, and apolipoprotein B concentrations. Insulin sensitivity, measured by the "steady state plasma glucose", obtained after a 150 min glucose-insulin-somatostatin infusion, improved in all patients but two. A significant correlation was observed between steady state plasma glucose variations, the glycosylated haemoglobin A1c (r = 0.70; p less than 0.005), total (r = 0.77; p less than 0.001), and LDL cholesterol (r = 0.69; p less than 0.005) and apolipoprotein B concentrations (r = 0.75; p less than 0.005).
Casimirri
F
F
Centro di Fisiopatologia della Nutrizione e Metabolismo, Università degli Studi di Bologna.
Pasquali
R
R
Melchionda
N
N
Biso
P
P
Capelli
M
M
Martelli
E
E
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D004043:Dietary Fiber / Q000494:pharmacology*; D005260:Female; D005685:Galactans / Q000494:pharmacology*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D008297:Male; D008351:Mannans / Q000494:pharmacology*; D008875:Middle Aged; D053149:Plant Gums
D001786:Blood Glucose; D004043:Dietary Fiber; D005685:Galactans; D006442:Glycated Hemoglobin; D007328:Insulin; D008055:Lipids; D008351:Mannans; D053149:Plant Gums; C007894:guar gum
Effetto del guar sui lipidi plasmatici e sulla attività biologica dell'insulina nei pazienti con diabete tipo 2.