title: Radioiododemercuration: a simple synthesis of 5-[123/125/127I]iodo-2'-deoxyuridine.
abstract: Through the use of iododemercuration, 5-[123/125I]iodo-2'-deoxyuridine was synthesized rapidly and with high radiochemical purity from 5-chloromercuri-2'-deoxyuridine. The synthesis of radioiodinated 2'-deoxyuridine was achieved in one step in the presence of Iodogen in 50% yield after isolation by reverse phase high performance column chromatography. The radiochemical purity was greater than 99%. The ease and the absence of any starting material, suggests that radiohalodemercuration may be the method of choice for this and structurally similar compounds.
authors.affiliation: Department of Radiology (Nuclear Medicine), Harvard Medical School, Boston, MA 02115.
authors.forename: J
authors.initials: J
authors.lastname: Baranowska-Kortylewicz
authors.forename: B M
authors.initials: BM
authors.lastname: Kinsey
authors.forename: W W
authors.initials: WW
authors.lastname: Layne
authors.forename: A I
authors.initials: AI
authors.lastname: Kassis
mesh_terms: D007065:Idoxuridine / Q000138:chemical synthesis*; D007457:Iodine Radioisotopes; D008722:Methods
chemical_list: D007457:Iodine Radioisotopes; D007065:Idoxuridine