title: [Bronchial asthma. Immunologic and biochemical aspects].
abstract: Bronchial asthma is a multifactorial condition, both as regards causes of illness and pathogenetic mechanisms. The pathogenetic mechanisms are discussed, starting with the type 1 allergic reaction as an inductor of mediator release from leukocytes in the bronchial mucosa. The article describes the interaction between bronchial smooth muscle contraction, vasodilatation, mucosal edema and increased mucosal secretions, with particular emphasis upon inflammatory changes and epithelial damage. It delineates the role of the nervous system, especially the parasympathetical nervous system, and the non-adrenergic non-cholinergic nervous system in the lung. The possibility of an interaction between mediator release and the parasympathetical nervous system is also discussed.
authors.forename: K H
authors.initials: KH
authors.lastname: Carlsen
mesh_terms: D001249:Asthma / Q000276:immunology* / Q000378:metabolism; D001980:Bronchi / Q000276:immunology / Q000378:metabolism; D006801:Humans; D015289:Leukotrienes / Q000378:metabolism; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000276:immunology; D010275:Parasympathetic Nervous System / Q000276:immunology / Q000378:metabolism
chemical_list: D015289:Leukotrienes
vernacular_title: Asthma bronchiale. Immunologiske og biokjemiske aspekter.