title: Myelinoid lamellated cytoplasmic inclusions in human renal adenocarcinomas: an ultrastructural study.
abstract: Ultrastructural study of 2 human renal adenocarcinomas demonstrated abundant myelinoid lamellated cytoplasmic inclusions, which were restricted to the neoplastic cells. They were structurally similar to those reported in renal adenocarcinomas chemically induced in rats; to those described in human diseases involving defects in lipid metabolism, including Gm2 gangliosidosis, Fabry's disease, Nieman-Pick disease, and juvenile-type neuronal ceroid-lipofuscinosis. Similar inclusions have also been reported to be induced by several drugs, none of which were taken by these patients. The occurrence of these lamellated inclusions in 2 human renal adenocarcinomas reinforces the phenotypic similarity between nitrosomorpholine-induced renal adenocarcinomas in rats and some renal adenocarcinomas seen in humans.
authors.affiliation: Department of Pathology, Indiana University School of Medicine, Indianapolis.
authors.forename: M T
authors.initials: MT
authors.lastname: Hull
authors.forename: J N
authors.initials: JN
authors.lastname: Eble
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000648:ultrastructure*; D003593:Cytoplasm / Q000648:ultrastructure; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D007680:Kidney Neoplasms / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009185:Myelin Proteins / Q000032:analysis
chemical_list: D009185:Myelin Proteins