Neurotoxicologic investigations of the pesticide dichlorvos (DDVP). Effects on the central and peripheral nervous system.
The neurotoxic effect on the central and peripheral nervous system of dichlorvos (DDVP) was investigated by a computer system in acute and subchronic experiments in CFY male rats. The administered peroral doses were given by gavage; the acute group was given a single 88 mg/kg dose and the 2 subchronic groups were given 1.6 mg/kg or 0.8 mg/kg daily for a period of 6 weeks. Significant changes of the function of CNS - increase of EEG mean frequency, decrease of EEG mean amplitude, that of activity of EEG bands (power density) - and peripheral nervous system - decrease of conduction velocity, increase of relative and absolute refractory periods - were found after treatment with both the single large and repeated small doses of dichlorvos. There were no correlations between the functional disturbances of the central and peripheral nervous systems and the inhibition of the cholinesterase activity in various organs and the blood.
Dési
I
I
Department of Hygiene and Epidemiology, Albert Szent-Györgyi University Medical School, Szeged, Hungary.
Nagymajtényi
L
L
D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced* / Q000503:physiopathology; D002802:Cholinesterases / Q000378:metabolism; D003201:Computers; D004006:Dichlorvos / Q000633:toxicity*; D004569:Electroencephalography; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats
D004006:Dichlorvos; D002802:Cholinesterases