[ATP-dependent calcium transport in the sarcoplasmic reticulum of the myocardium during vitamin E deficiency in the rat diet].
The vitamin E deficiency in the rat diet was studied for its effect on the activity of Ca2+-pump and phosphorylation of sarcoplasmic reticulum membrane fragments of myocardium. It is shown that under such an antioxidant deficiency ATP-dependent accumulation of calcium is 2.5 times as low, from 490 down to 190 nmol/mg of protein for 5 min. The administration of ionol, a synthetic antioxidant, to animals reduces the level of calcium accumulation, it is 1.8 times as high as that with vitamin E deficiency; cAMP-dependent phosphorylation of the sarcoplasmic reticulum preparation membranes of the test animal myocardium produces a 1.6-2.1 times increase in them of the ATP-dependent accumulation of calcium, the kinetics of Ca2+ accumulation is unchanged.
Gubskiĭ
Iu I
IuI
Kalinskiĭ
M I
MI
Rudnitskaia
N D
ND
Zadorina
O V
OV
Kurskiĭ
M D
MD
D000255:Adenosine Triphosphate / Q000502:physiology*; D000818:Animals; D001692:Biological Transport; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D004032:Diet; D005260:Female; D008054:Lipid Peroxides / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*; D014811:Vitamin E Deficiency / Q000378:metabolism*
D008054:Lipid Peroxides; D008563:Membrane Lipids; D002084:Butylated Hydroxytoluene; D000255:Adenosine Triphosphate; D000242:Cyclic AMP; D002118:Calcium
ATP-zavisimyĭ transport kal'tsiia v sarkoplazmaticheskom retikulume miokarda pri nedostatke vitamina E v ratsione krys.