Adenovirus-induced immune complexes in ovine fetuses.
The formation of immune complexes (IC) was studied in 60- to 70-day-old ovine fetuses experimentally infected with adenovirus. The PEG-6000-precipitated, circulating IC appeared in the blood stream of fetuses between days 5 and 10 postinfection (PI), and persisted there even to PI day 19. Using anti-IgG and anti-IgM conjugate, the complexes were demonstrable by immunofluorescence (IF) and also in the lung, spleen and kidney tissues on day 19, however, the complexes failed to react to an anti-complement C3 serum. The histopathological changes seen in the organs allow us to conclude that the IC might play an important role in the pathogenesis of fetopathies.
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D000257:Adenoviridae Infections / Q000276:immunology / Q000662:veterinary*; D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis*; D005260:Female; D005333:Fetus / Q000276:immunology*; D011247:Pregnancy; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology*; D014018:Tissue Distribution
D000936:Antigen-Antibody Complex