title: A ten-year experience in control of poliomyelitis through a combination of live and killed vaccines in two developing areas.
abstract: We describe a successful program of poliomyelitis control using a combination of killed and live polio vaccines over a 10-year period in two developing areas, the West Bank and Gaza, adjacent to a relatively developed country, Israel. During the 1970s, immunization using live trivalent oral polio vaccine (OPV) in these areas covered more than 90 percent of the infant population. Nevertheless, the incidence of paralytic polio continued to be high, with many cases occurring in fully or partially immunized persons. It was thought that this could be due to interference with OPV take by other enteroviruses present in the environment due to poor sanitary conditions in these areas. A new policy combining five doses of OPV with two doses of inactivated polio vaccine (IPV) was adopted and implemented in 1978. In the 10 years since then, immunization coverage of infants increased to an estimated 95 percent and paralytic poliomyelitis has been controlled, despite exposure to wild poliovirus from neighboring countries including an outbreak in Israel in 1988. This experience suggests that wide coverage using the combination of IPV and OPV is an effective vaccination policy that may make eradication of polio possible even in developing areas.
authors.affiliation: Personal and Community Preventive Health Services, Israel Ministry of Health, Jerusalem.
authors.forename: T
authors.initials: T
authors.lastname: Tulchinsky
authors.forename: Y
authors.initials: Y
authors.lastname: Abed
authors.forename: S
authors.initials: S
authors.lastname: Shaheen
authors.forename: N
authors.initials: N
authors.lastname: Toubassi
authors.forename: Y
authors.initials: Y
authors.lastname: Sever
authors.forename: M
authors.initials: M
authors.lastname: Schoenbaum
authors.forename: R
authors.initials: R
authors.lastname: Handsher
mesh_terms: D004196:Disease Outbreaks; D006291:Health Policy; D006801:Humans; D015994:Incidence; D007223:Infant; D007557:Israel / Q000453:epidemiology; D011051:Poliomyelitis / Q000453:epidemiology / Q000517:prevention & control*; D011054:Poliovirus Vaccine, Inactivated / Q000627:therapeutic use*; D011055:Poliovirus Vaccine, Oral / Q000627:therapeutic use*; D016036:Seroepidemiologic Studies; D014611:Vaccination
chemical_list: D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral