title: [Modification by cycloheximide of the effects of insulin on the transport of calcium by sarcolemma of the myocardium].
abstract: The inhibitory effect of insulin on Ca2+-current was supposed to be due to activation of phosphoproteinphosphotases stimulated by a specific intracellular insulin messenger. The results obtained support the above suggestion. Pretreatment of myocardial preparation with cycloheximide in low concentrations completely blocks the inhibitory insulin effect on Ca2+-current due, probably, to a decrease in peptide formation. Moreover, prolonged effect of the hormone involves a considerable increase of the current as compared to its initial value. Possible mechanisms of modifying effect of cycloheximide on the function of insulin-dependent regulatory system in the myocardium, are discussed.
authors.forename: O V
authors.initials: OV
authors.lastname: Nakipova
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Kokoz
authors.forename: A V
authors.initials: AV
authors.lastname: Lazarev
authors.forename: A A
authors.initials: AA
authors.lastname: Freĭdin
authors.forename: V A
authors.initials: VA
authors.lastname: Krupenin
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003513:Cycloheximide / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007329:Insulin Antagonists / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D011895:Rana ridibunda; D012508:Sarcolemma / Q000187:drug effects* / Q000378:metabolism
chemical_list: D007329:Insulin Antagonists; D003513:Cycloheximide; D010749:Phosphoprotein Phosphatases; D002118:Calcium
vernacular_title: Modifikatsiia tsiklogeksimidov éffektov insulina na transport kal'tsiia sarkolemmoĭ miokarda.