Naloxone reversal of hemorrhagic hypotension in the conscious guinea-pig is impeded by inhibition of the renin-angiotensin II system.
Naloxone reverses hemorrhagic hypotension in the conscious guinea-pig. Captopril and saralasin impede this naloxone effect, suggesting that angiotensin II is involved in naloxone action. This is compatible with previous work which has shown that B-endorphin inhibits the centrally mediated pressor action of angiotensin II, and that naloxone blocks this effect. Naloxone may be interacting with the postulated brain renin-angiotension II system or may be blocking the action of shock-induced circulating angiotensin II on a centrally located area such as the hypothalamus.
Innanen
V T
VT
Jobb
E
E
Korogyi
N
N
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology; D006168:Guinea Pigs; D006470:Hemorrhage / Q000503:physiopathology*; D007022:Hypotension / Q000503:physiopathology*; D007031:Hypothalamus / Q000187:drug effects; D009270:Naloxone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009433:Neural Inhibition / Q000187:drug effects*; D011957:Receptors, Opioid / Q000187:drug effects*; D012084:Renin-Angiotensin System / Q000187:drug effects*; D012504:Saralasin / Q000494:pharmacology
D011957:Receptors, Opioid; D009270:Naloxone; D002216:Captopril; D012504:Saralasin