title: Cyclic AMP control of GTP pools in Saccharomyces cerevisiae.
abstract: Previous studies have shown that GTP and cyclic AMP have similar effects on the regulation of sporulation in the yeast Saccharomyces cerevisiae. Declines in either nucleotide can trigger sporulation. These results raise the question whether either nucleotide influences the pool of the other. The current study shows that a cyclic AMP deficiency produces a decline in GTP pools and cyclic AMP readdition quickly increases GTP pools. UTP but not CTP shows a similar pattern of control to that shown by GTP. These results suggest that cyclic AMP effects on sporulation and possibly other cell properties may be mediated in part or in whole by GTP. They provide support for the hypothesis that GTP has a general role in stimulating cellular growth and proliferation.
authors.affiliation: Program in Genetics and Cell Biology, Washington State University, Pullman 99164-4350.
authors.forename: M L
authors.initials: ML
authors.lastname: Pall
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D002455:Cell Division; D000242:Cyclic AMP / Q000494:pharmacology / Q000502:physiology*; D006160:Guanosine Triphosphate / Q000378:metabolism*; D007700:Kinetics; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000502:physiology*; D013172:Spores, Fungal / Q000187:drug effects; D014544:Uridine Triphosphate / Q000378:metabolism
chemical_list: D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D000242:Cyclic AMP; D014544:Uridine Triphosphate