title: Asbestos catalyzes the formation of the 6-oxobenzo[a]pyrene radical from 6-hydroxybenzo[a]pyrene.
abstract: Crocidolite asbestos catalyzes the oxidation of 6-hydroxybenzo[a]pyrene, a metabolite of benzo[a]pyrene, to the 6-oxobenzo[a]pyrene radical as determined by electron spin resonance spectroscopy. This may be a mechanism whereby inhaled asbestos enhances the incidence of lung cancer induced by cigarette smoke, which contains benzo[a]pyrene.
authors.affiliation: Boston Biomedical Research Institute, Department of Muscle Research, Massachusetts 02114.
authors.forename: P
authors.initials: P
authors.lastname: Graceffa
authors.forename: S A
authors.initials: SA
authors.lastname: Weitzman
mesh_terms: D001194:Asbestos; D017638:Asbestos, Crocidolite; D001580:Benzopyrenes; D004578:Electron Spin Resonance Spectroscopy; D007700:Kinetics
chemical_list: D001580:Benzopyrenes; D017638:Asbestos, Crocidolite; D001194:Asbestos; C014729:6-oxybenzo(a)pyrene; C023395:6-hydroxybenzo(a)pyrene