Monoclonal antibodies directed against a 130K glycoprotein of bovine herpesvirus 2 cross-react with glycoprotein B of herpes simplex virus.
Envelope proteins of bovine herpesvirus type 2 (BHV-2) and herpes simplex virus types 1 and 2 (HSV-1, -2) share cross-reacting determinants. Monoclonal antibodies directed against epitopes of a 130K glycoprotein of BHV-2 detect determinants on the surface of infected cells and react either with cytoplasmic or nuclear antigens. Biological and biochemical characterization of the proteins recognized by these antibodies revealed that the BHV-2 specific 130K glycoprotein and the gB of HSV share common epitopes. Some of them are involved in the neutralization of HSV and BHV-2.
Conraths
F J
FJ
Institute of Virology, Free University of Berlin, Federal Republic of Germany.
Pauli
G
G
Ludwig
H
H
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology; D003429:Cross Reactions; D006023:Glycoproteins / Q000276:immunology*; D006564:Herpesviridae / Q000276:immunology*; D001911:Herpesvirus 2, Bovine / Q000276:immunology*; D007122:Immunoelectrophoresis; D009500:Neutralization Tests; D018139:Simplexvirus / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D006023:Glycoproteins; D014759:Viral Envelope Proteins; C040495:glycoprotein B, Simplexvirus; C044525:glycoprotein B, herpes simplex virus type 2