[Global approach to the treatment of small cell bronchial cancers].
320 patients were included in a trial fo chemotherapy with cyclophosphamide/adriamycin/etoposide/CCNU. A first randomization tested the effect of acetyl-salicylic acid as an anti-aggregant agent. The second randomization studied the result of maintenance chemotherapy. Patients were treated by prophylactic central nervous system irradiation. The results are analyzed according to different prognostic factors such as age, performance status, histological pattern and the center.
Lebeau
B
B
Service de Pneumologie, Hôtel-Dieu, Paris.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001241:Aspirin / Q000008:administration & dosage; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000532:radiotherapy; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D011897:Random Allocation
D005047:Etoposide; D008130:Lomustine; D004317:Doxorubicin; D003520:Cyclophosphamide; D001241:Aspirin
Approche globale du traitement des cancers bronchiques à petites cellules.