Suppression by gamma-hydroxybutyric acid of ethanol withdrawal syndrome in rats.
The ability of gamma-hydroxybutyric acid to suppress ethanol withdrawal syndrome was tested in male rats rendered physically dependent on ethanol by several intragastric administrations of ethanol (9-15 g/kg daily for 7 days). Gamma-hydroxybutyrate (0.25, 0.50 and 1.00 g/kg i.p.), administered 8 hr after the last ethanol dose, produced a dose-dependent inhibition of withdrawal signs such as tremors and audiogenically-induced seizures; the highest dose tested suppressed all ethanol withdrawal symptoms.
Fadda
F
F
Institute of Physiology, University of Cagliari, Italy.
Colombo
G
G
Mosca
E
E
Gessa
G L
GL
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000009:adverse effects*; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012978:Sodium Oxybate / Q000627:therapeutic use*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D006885:Hydroxybutyrates; D000431:Ethanol; D012978:Sodium Oxybate