[Regulating and disturbing effects of alpha-tocopherol on lipid bilayers].
Using the high resolution 1H-NMR spectroscopy and spin-probes the influence of alpha-tocopherol on lipid bilayer microviscosity has been studied. It has been established that alpha-tocopherol shows the cholesterol-like action on the physical state of lipid bilayer: alpha-tocopherol increase microviscosity of unsaturated bilayers and decrease microviscosity of saturated bilayers. The character of alpha-tocopherol action is determined by the fatty acidic lipid composition but does not depend on the polar group structure of phospholipid molecule as cholesterol-like action of alpha-tocopherol is found itself in liposomes prepared both from phosphatidylcholine and phosphatidylethanolamine. Analog of alpha-tocopherol without phytol chain 2,2,5,7,8-penthamethyl-6-oxychroman does not show the cholesterol-like action as it is not able to disorder the saturated bilayers.
Gorbunov
N V
NV
Skrypin
V I
VI
Tiurin
V A
VA
Balevska
P
P
Serbinova
E
E
D004578:Electron Spin Resonance Spectroscopy; D008051:Lipid Bilayers; D008560:Membrane Fluidity / Q000187:drug effects*; D010743:Phospholipids; D014783:Viscosity; D014810:Vitamin E / Q000494:pharmacology*
D008051:Lipid Bilayers; D010743:Phospholipids; D014810:Vitamin E
Uporiadochivaiushchee i razuporiadyvaiushchee deĭstvie alpha-tokoferola na lipidnye bisloi.