The molecular basis of HbH disease in Taiwan.
We have determined the molecular characteristics of alpha-thalassemia in 12 HbH subjects from Taiwan by restriction endonuclease mapping with alpha- and zeta-specific probes. We have found four types of defects in the alpha-thalassemia-2 genetic determinant: -alpha 3.7 type I; -alpha 4.2; alpha CS alpha; and alpha alpha T. All HbH subjects carried the --SEA genotype in the alpha-thalassemia-1 determinant. At least two different subtypes of --SEA genotype were observed in this study.
Peng
H W
HW
Department of Medicine, Veterans General Hospital, Taipei, Taiwan, Republic of China.
Han
S H
SH
Chow
T Y
TY
Ho
C H
CH
Ching
K N
KN
Chiang
B N
BN
D004262:DNA Restriction Enzymes; D005838:Genotype; D006447:Hemoglobin H / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D013624:Taiwan; D013789:Thalassemia / Q000235:genetics*
D006455:Hemoglobins, Abnormal; D006447:Hemoglobin H; D004262:DNA Restriction Enzymes