[Molecular mechanisms of the action of insulin].
Molecular mechanisms of insulin action on metabolism such as interaction with membrane receptor, autophosphorylation of receptor, internalization of insulin-receptor complexes into cells, changes in the processes of transcription, RNA release from nuclei, translation and post-translation modification of proteins and key enzymes are considered. The role of mediators in realization of biological effects of insulin is analyzed. It is emphasized that insulin action on the gene expression is an important link of its influence on metabolism.
Minchenko
A G
AG
D000818:Animals; D000242:Cyclic AMP / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000502:physiology*; D011972:Receptor, Insulin / Q000502:physiology*
D007328:Insulin; D000242:Cyclic AMP; D011972:Receptor, Insulin
Molekuliarnye mekhanizmy deĭstviia insulina.