Treatment of lung cancer with bronchial artery infusion of cisplatin and intravenous sodium thiosulfate rescue.
Forty-nine patients with primary lung cancer were treated with bronchial artery infusion of cisplatin and intravenous injection of and antidote, sodium thiosulfate. More than 50% reduction of tumor size (PR) was observed in 8 of 9 small cell carcinomas (SCLC) and in 16 of 40 non-small cell carcinomas (NSCLC). In NSCLC patients PR was obtained in 71% (12/17) after repeated infusion (greater than or equal to 200 mg cisplatin) and in 17% (4/23) after a single infusion (less than or equal to 150 mg cisplatin). There was a significant linear relationship between cisplatin dose and tumor reduction in this group. No severe adverse effects were encountered.
Uchiyama
N
N
Department of Radiology, Faculty of Medicine, Kagoshima University, Japan.
Kobayashi
H
H
Nakajo
M
M
Shinohara
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001981:Bronchial Arteries; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D018288:Carcinoma, Small Cell / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013885:Thiosulfates / Q000627:therapeutic use*
D013885:Thiosulfates; C017717:sodium thiosulfate; D002945:Cisplatin