title: [Intensification of the diabetogenic effect of alloxan by protamine sulfate].
abstract: Administration of protamine sulfate into circulation was shown to increase the diabetogenic effect of alloxan. Protamine sulfate bound endogenous heparin, as a result of which the diabetogenic factor caused more severe forms of experimental diabetes. At the same time, the diabetogenic factor exhibited distinctly higher activity during the heparin deficiency developed.
authors.forename: B A
authors.initials: BA
authors.lastname: Kudriashov
authors.forename: A M
authors.initials: AM
authors.lastname: Ul'ianov
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Tarasov
mesh_terms: D000496:Alloxan / Q000633:toxicity*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000378:metabolism; D006494:Heparin Antagonists; D008297:Male; D011479:Protamines / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical
chemical_list: D006494:Heparin Antagonists; D011479:Protamines; D000496:Alloxan
vernacular_title: Usilenie protamina sul'fatom diabetogennogo deĭstviia alloksana.