[Treatment of experimental infection by Strongyloides venezuelensis in rats, with the use of injectable ivermectin and levamisole].
For the therapy of human strongyloidiasis, are necessary effective drugs to eliminate both larvae and adult worm parasitism, which may also be used by parenteral route, to obviate the particular conditions presented by many patients. A study based on the experimental infection by Strongyloides venezuelensis in rats was done, administering injectable ivermectin or levamisole. Both drugs were shown to be active, when used in single doses of 0.2 to 0.5 mg/kg of ivermectin, or 26 mg/kg for levamisole. Ivermectin was slightly more effective as far as larval stage of the infection is concerned, and the same happened for levamisole for the adult worm stage. Promising perspectives are visualized to improve the therapy of patients with serious disseminated infection by Strongyloides stercoralis.
Campos
R
R
Pinto
P L
PL
Amato Neto
V
V
Matsubara
L
L
Miyamoto
A
A
de Carvalho
S A
SA
Takiguti
C K
CK
Moreira
A A
AA
D000818:Animals; D007279:Injections, Subcutaneous; D007559:Ivermectin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007978:Levamisole / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013321:Strongyloides / Q000187:drug effects; D013322:Strongyloidiasis / Q000188:drug therapy*
D007978:Levamisole; D007559:Ivermectin
Tratamento da infecção experimental de ratos por Strongyloides venezuelensis, mediante uso da ivermectina e do levamisol injectáveis.