title: [Fatty-acid initiated auto-oxidation of hemoglobin].
abstract: The interaction of fatty acids (FA) with oxyhemoglobin (HbO2) was investigated. It was found that under effect of FA HbO2 is converted into the oxidized low-spin form, i. e., hemichrome. An increase in the level of reactive oxygen species was registered by the ESP method, using the spin traps, 1.2-dioxybenzo-3.5-disulphonate (tiron) and 5.5-dimethylpyrroline-1-oxide (DMPO). To investigate the nature of radical particles, the OH radical traps. thiourea and D-mannitol, as well as superoxide dismutase (SOD) and catalase were employed. The mechanism of interaction of HbO2 and FA is discussed; its feasible physiological role in the functioning of erythrocytes is postulated.
authors.forename: A A
authors.initials: AA
authors.lastname: Akhrem
authors.forename: G M
authors.initials: GM
authors.lastname: Andreiuk
authors.forename: N A
authors.initials: NA
authors.lastname: Gurinovich
authors.forename: M A
authors.initials: MA
authors.lastname: Kisel'
authors.forename: P A
authors.initials: PA
authors.lastname: Kiselev
mesh_terms: D000818:Animals; D002417:Cattle; D003574:Cytochrome c Group / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism*; D006461:Hemolysis; D007700:Kinetics; D010084:Oxidation-Reduction; D010108:Oxyhemoglobins / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism
chemical_list: D003574:Cytochrome c Group; D005227:Fatty Acids; D010108:Oxyhemoglobins; D013481:Superoxides
vernacular_title: Initsiiruemoe zhirnymi kislotami avtookislenie gemoglobina.