title: Studies of depressed interleukin-2 production by spleen cells from mice following infection with cytomegalovirus.
abstract: Spleen cells from mice infected with virulent and avirulent strains of murine cytomegalovirus showed depressed interleukin-2 production after ConA stimulation. Cell-mixing experiments indicated that this was due to a primary defect in non adherent cells. Spleen cells infected in vitro were also studied.
authors.affiliation: Department of Microbiology, United Medical and Dental School, Guy's Hospital, London, U.K.
authors.forename: S
authors.initials: S
authors.lastname: Blackett
authors.forename: C A
authors.initials: CA
authors.lastname: Mims
mesh_terms: D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D003586:Cytomegalovirus Infections / Q000276:immunology*; D007108:Immune Tolerance; D007376:Interleukin-2 / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D051379:Mice; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
chemical_list: D007376:Interleukin-2; D003208:Concanavalin A