Inhibitory effect of retinoid (E5166) on cell growth and suppressive effect on Epstein-Barr virus early-antigen induction by n-butyrate in nasopharyngeal hybrid cells.
The in vitro proliferation and colony-forming activity (plating efficiency) of Epstein-Barr virus (EBV) nuclear antigen-positive nasopharyngeal hybrid cells were inhibited by one of the retinoid, polyprenoic acid; E5166. It was dependent on retinoid concentration. Furthermore, an induction of EBV early antigen after treatment with 4 mM n-butyrate was markedly suppressed by E5166 and this was similar to the previously reported effects of retinoid acid on iododeoxyuridine (IUDR) and 12-O-tetra-decanoyl-phorbol-13-acetate (TPA) induction. These results support to lead a clinical application of E5166 for combination chemotherapy in patients with nasopharyngeal carcinoma.
Furukawa
M
M
Umeda
R
R
D000957:Antigens, Viral, Tumor / Q000096:biosynthesis*; D002087:Butyrates / Q000494:pharmacology; D020148:Butyric Acid; D002277:Carcinoma / Q000188:drug therapy*; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D004854:Herpesvirus 4, Human / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000517:prevention & control*; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014412:Tumor Virus Infections / Q000188:drug therapy*
D000957:Antigens, Viral, Tumor; D002087:Butyrates; D020148:Butyric Acid; D014212:Tretinoin; C034534:3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid