[Hepatocyte receptors for polymerized albumin. Experimental study on isolated hepatocytes and in vivo animals].
In the present work receptors for polymerized rat serum albumin (P-RSA) were studied by incubation of radiolabelled polymers with rat hepatocytes isolated with mechanical techniques. Isolated rat hepatocytes showed a receptor activity for polymerized albumin and such a membrane receptor seems to be controlled by the cellular cytoskeleton. During rat total body scintigraphy receptor expression was detected exclusively in the liver. These observations support the hypothesis of a selective receptor activity of the liver cells for polymerized albumin. To confirm our results, further studies were performed on rat bile, after 125I-P-RSA infusion in vivo.
Trevisan
A
A
Università di Padova, Istituto di Medicina Clinica, Ospedale Civile di Padova.
Cavigli
R
R
Stenico
D
D
Casara
D
D
Pasquali
C
C
Capri
C
C
D000818:Animals; D001646:Bile / Q000378:metabolism; D007457:Iodine Radioisotopes; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism*; D011877:Radionuclide Imaging; D051381:Rats; D017457:Receptors, Albumin; D011956:Receptors, Cell Surface / Q000378:metabolism*
D007457:Iodine Radioisotopes; D017457:Receptors, Albumin; D011956:Receptors, Cell Surface
Recettori epatocitari per albumina polimerica. Studio sperimentale su epatociti isolati ed animali in vivo.