Significance of thrombin-receptors of thrombocytes for the interaction of heparins and low-molecular-weight heparin in human whole blood clotting.
We describe in the present paper the results of the influence of normal and low-molecular-weight heparin on the interaction of human fibrinogen and thrombocytes in human whole blood cotting ex vivo. During the coagulation process sequential measurements of fibrinopeptide A reflect fibrin formation and determination of platelet factor 4 indicate activation of thrombocytes. The data show that low-molecular-weight heparin inhibits plasma thrombin generation in vivo for longer than normal heparin and it affects the fibrinogen platelet binding less. There is good evidence that a lonely factor Xa inhibition mediates this anticoagulant mechanism. Therefore, these data favor the hypothesis that antifactor Xa activity prevents indeed blood clotting.
Harenberg
J
J
Medical Clinic I, Klinikum Mannheim, University of Heidelberg, FRG.
Schuler
M
M
Zimmermann
R
R
Heptner
W
W
D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D006493:Heparin / Q000494:pharmacology*; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology*; D006801:Humans; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism; D018179:Receptors, Thrombin; D014914:Whole Blood Coagulation Time
D006495:Heparin, Low-Molecular-Weight; D011956:Receptors, Cell Surface; D018179:Receptors, Thrombin; D006493:Heparin