[A study of thermoinduced changes in human high-density lipoproteins in hypo-alpha-lipoproteinemia and ischemic heart disease by the spin label method].
Thermo-induced structural reorganization in human high density lipoproteins subclasses HDL2 and HDL3 have been studied by means of electronic paramagnetic resonance method. A number of spin labels were used: 5- and 16-DOXYL stearates, DOXYL-labelled derivatives of pentadecane, phosphatidyl choline and sphingomyelin. In hypoalphalipoproteinemia one of the thermo-induced transitions in HDL2 (at 23-30 degrees) was not observed. In coronary heart disease the critical temperature for HDL3 was shifted from the physiological values and located at 42-48 degrees. The data obtained are discussed from the point of view of their potential role in atherogenesis.
Gorshkova
I N
IN
Noeva
E A
EA
Polesskiĭ
V A
VA
Perova
N V
NV
Ruuge
E K
EK
D000328:Adult; D003327:Coronary Disease / Q000097:blood*; D004578:Electron Spin Resonance Spectroscopy; D006358:Hot Temperature; D006801:Humans; D007009:Hypolipoproteinemias / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged
D008075:Lipoproteins, HDL
Issledovanie termoindutsirovannykh izmeneniĭ v lipoproteidakh vysokoĭ plotnosti cheloveka pri gipoal'falipoproteidemii i ishemicheskoĭ bolezni serdtsa metodom spinovykh zondov.