title: Reversal of the intrinsic effects of Ro 15-4513 on exploratory behavior by two benzodiazepine receptor antagonists.
abstract: In a holeboard test the imidazodiazepine Ro 15-4513 (1.5 and 3.0 mg/kg) reduced exploratory head-dipping. This effect was reversed both by the imidazodiazepine Ro 15-1788 (5 mg/kg) and by the beta-carboline ZK 93426 (2.5 mg/kg). These results indicate that the reduction in exploration caused by Ro 15-4513 is mediated by central benzodiazepine receptors.
authors.affiliation: Laboratory of Clinical Studies, DICBR, NIAAA, Bethesda, MD 20892.
authors.forename: R G
authors.initials: RG
authors.lastname: Lister
mesh_terms: D000818:Animals; D001386:Azides / Q000494:pharmacology*; D001569:Benzodiazepines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects*; D005442:Flumazenil / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects*
chemical_list: D001386:Azides; D002243:Carbolines; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D005442:Flumazenil; C042568:ZK 93426; C042957:Ro 15-4513