title: Tobacco smokers' neutrophils are desensitized to chemotactic peptide-stimulated oxygen uptake.
abstract: Chemotactic peptide-stimulated oxygen uptake and superoxide release were measured in neutrophils from a group of age- and race-matched male tobacco smokers and nonsmokers. The stimulated oxygen uptake in smokers was less than that of nonsmokers. This decreased sensitivity to formyl-methionyl-leucyl-phenylalanine (FMLP) stimulation of O2 uptake was the result of an altered apparent Km and was paralleled by a decrement in superoxide release in smokers. These alterations in neutrophil function, coupled with our previous observation of altered tritiated FMLP binding in smokers, support the hypothesis of a modified response to FMLP in chronic smoker's neutrophils.
authors.affiliation: Department of Oral Biology and Medicine, University of Kentucky Medical Center, Lexington.
authors.forename: E E
authors.initials: EE
authors.lastname: Codd
authors.forename: A T
authors.initials: AT
authors.lastname: Swim
authors.forename: R B
authors.initials: RB
authors.lastname: Bridges
mesh_terms: D000328:Adult; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology*; D009504:Neutrophils / Q000378:metabolism*; D010101:Oxygen Consumption; D012907:Smoking / Q000097:blood*; D013481:Superoxides / Q000097:blood
chemical_list: D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine