[Fatal pulmonary leukoagglutination after administration of fresh frozen plasma].
A case is reported of a 73 year old female patient who died during surgery for enlarged nephrectomy as a result of a massive non-cardiogenic pulmonary oedema. She had been given 2 red cell concentrates (450 g) and 3 fresh frozen plasma units (900 g). A postmortem examination did not reveal any pulmonary embolus, acute myocardial infarct, haemorrhage or cardiac tamponade. Further tests on the sera of the 5 plasma donors revealed a neutrophil-specific anti-NA2 antibody. Alveolar leukostasis was confirmed on the postmortem lung slices. This type of transfusion accident occurs for about 1 in 5,000 units transfused, fortunately not all as serious. This case confirms once more that fresh frozen plasma is not the ideal treatment for acute hypovolaemia, 4% human albumin being safer.
Cléro
B
B
Service d'Anesthésie-Réanimation, Hôpital Necker-Enfants Malades, Paris.
Celton
J L
JL
Atinault
A
A
Cazalaa
J B
JB
Barrier
G
G
D000368:Aged; D000371:Agglutination; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D007962:Leukocytes / Q000276:immunology / Q000473:pathology; D010949:Plasma; D011654:Pulmonary Edema / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D065227:Transfusion Reaction
D007518:Isoantibodies
Leucoagglutination pulmonaire mortelle après administration de plasma frais congelé.