Development of intestinal mucosal barrier function to antigens and bacterial toxins.
In this paper, we have tried to provide evidence for the association between the microvillus membrane immaturity of young infants/animals and the enhanced attachment and uptake of intestinal antigens and toxins. Finally, we have reviewed observations that growth factors that alter the newborn MVM composition towards maturity may also affect the handling of antigens by the intestinal surface.
Israel
E J
EJ
Harvard Medical School, Children's Hospital, Boston, MA.
Walker
W A
WA
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D000941:Antigens / Q000378:metabolism*; D001422:Bacterial Adhesion; D018407:Bacterial Physiological Phenomena; D001427:Bacterial Toxins / Q000378:metabolism; D003348:Cortisone / Q000494:pharmacology; D006001:Glycoconjugates / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D007413:Intestinal Mucosa / Q000502:physiology*; D008560:Membrane Fluidity; D008871:Microvilli / Q000502:physiology; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology
D000941:Antigens; D001427:Bacterial Toxins; D006001:Glycoconjugates; D006133:Growth Substances; D011956:Receptors, Cell Surface; D003348:Cortisone