title: Action of trapidil on the heart contractility: relationship to the cyclic nucleotide metabolism.
abstract: The relationship between the cardiotonic action of trapidil (RocornalR) and cyclic nucleotide metabolism was studied in the isolated rat heart. The contractility of the heart was increased in a concentration-dependent manner by this drug (ED50 20/microM). Parallel with the mechanical changes the tissue levels of cyclic AMP were increased, which was associated with an activation of the cAMP-dependent protein kinase. Cyclic GMP was enhanced only at a drug concentration of 1 mM. The present findings support the hypothesis that the cyclic nucleotide system is involved in the functional action of trapidil on cardiac tissue.
authors.affiliation: Central Institute for Cardiovascular Research, Academy of Sciences of the GDR, Berlin-Buch.
authors.forename: S
authors.initials: S
authors.lastname: Bartel
authors.forename: D
authors.initials: D
authors.lastname: Reese
authors.forename: E G
authors.initials: EG
authors.lastname: Krause
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014192:Trapidil / Q000494:pharmacology*
chemical_list: D009712:Nucleotides, Cyclic; D011743:Pyrimidines; D000242:Cyclic AMP; D011494:Protein Kinases; D014192:Trapidil; D006152:Cyclic GMP