title: [Directed biosynthesis of prostaglandin F2 alpha multiple labeled with tritium].
abstract: By selecting specific activators of PGF reductase and determining their optimal ratio, we have performed the directed biosynthesis of PGF2 alpha with a 45-50% yield. With the use of [5,6,8,9,11,12,14,15-3H8]arachidonic acid, multiple-labelled PGF2 alpha with molar radioactivity 6.1 TBe/mmol has been synthesised.
authors.forename: L A
authors.initials: LA
authors.lastname: Iakusheva
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Nagaev
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Lazurkina
authors.forename: V P
authors.initials: VP
authors.lastname: Shevchenko
authors.forename: G I
authors.initials: GI
authors.lastname: Miagkova
mesh_terms: D011452:15-Oxoprostaglandin 13-Reductase / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D015237:Dinoprost; D007553:Isotope Labeling; D011460:Prostaglandins F / Q000096:biosynthesis*; D014316:Tritium
chemical_list: D011460:Prostaglandins F; D014316:Tritium; D015237:Dinoprost; D011452:15-Oxoprostaglandin 13-Reductase
vernacular_title: Napravlennyĭ biosintez kratnomechennogo tritiem prostaglandina F2 alpha.