The role of iron in the initiation of lipid peroxidation.
Iron is required for the initiation of lipid peroxidation. Evidence is presented that lipid peroxidation requires both Fe3+ and Fe2+, perhaps with oxygen to form a Fe3+-dioxygen-Fe2+ complex. Other mechanisms of initiation, mostly involving the iron-catalyzed formation of hydroxyl radical, are described and discussed from both theoretical and experimental view points.
Minotti
G
G
Department of Biochemistry, Michigan State University, East Lansing 48824-1319.
Aust
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SD
D005609:Free Radicals; D006878:Hydroxides; D017665:Hydroxyl Radical; D007501:Iron / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D010544:Peroxidases / Q000378:metabolism*
D005609:Free Radicals; D006878:Hydroxides; D008054:Lipid Peroxides; D017665:Hydroxyl Radical; D007501:Iron; D010544:Peroxidases