title: Major liver resection for hilar cholangiocarcinoma.
abstract: Between 1968 and 1984 liver resection with curative attempt was performed in 22 patients with hilar cholangiocarcinoma. Right lobectomy was performed in 4 patients, extended right lobectomy in 7, left lobectomy in 8, and excision of the median segment segment of the left lobe (segment IV) in 3. Bilio-enteric continuity was restored by hepatocholedochostomy in 17 patients and hepatojejunostomy in 4. (One patient had external transhepatic catheter drainage and no internal bile drainage.) Operative mortality rate was 27% and caused by excessive intraoperative bleeding, sepsis, or liver insufficiency. Postoperative complications occurred in 57% of patients surviving the operation and were due mainly to leakage from the hepatocholedochostomy. Median survival was 6 months, and one third of the patients survived 1 year. Three patients survived 10 years and were among the four patients in whom a tumor-free resection margin was obtained (one of them died in the postoperative phase). It is concluded that resection of hilar cholangiocarcinoma may give long-term survival if a free resection margin is obtained. The importance of a free resection margin indicates that surgery should be aggressive and include liver resection.
authors.affiliation: Department of Surgery, Lund University, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Bengmark
authors.forename: H
authors.initials: H
authors.lastname: Ekberg
authors.forename: A
authors.initials: A
authors.lastname: Evander
authors.forename: B
authors.initials: B
authors.lastname: Klofver-Stahl
authors.forename: K G
authors.initials: KG
authors.lastname: Tranberg
mesh_terms: D002759:Adenoma, Bile Duct / Q000401:mortality / Q000601:surgery*; D000328:Adult; D000368:Aged; D003135:Common Bile Duct / Q000601:surgery; D003138:Common Bile Duct Neoplasms / Q000145:classification / Q000401:mortality / Q000601:surgery*; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D007583:Jejunum / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D011183:Postoperative Complications / Q000401:mortality