title: Allergic reaction with immune hemolytic anemia resulting from chlorambucil.
abstract: In a 73-year-old female with chronic lymphocytic leukemia we observed an acute illness with shivering, high fever, and hemolytic anemia following chlorambucil administration. Reexposure in a controlled clinical situation suggested an allergic drug reaction. In an in vitro assay, we were able to demonstrate chlorambucil as the causative agent of immune hemolysis.
authors.affiliation: Klinikum Charlottenburg der Freien Universität, Berlin, Federal Republic of Germany.
authors.forename: L
authors.initials: L
authors.lastname: Thompson-Moya
authors.forename: T
authors.initials: T
authors.lastname: Martin
authors.forename: H G
authors.initials: HG
authors.lastname: Heuft
authors.forename: A
authors.initials: A
authors.lastname: Neubauer
authors.forename: R
authors.initials: R
authors.lastname: Herrmann
mesh_terms: D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy*; D002699:Chlorambucil / Q000009:adverse effects* / Q000627:therapeutic use; D003298:Coombs Test; D004342:Drug Hypersensitivity / Q000175:diagnosis; D005260:Female; D006801:Humans; D012698:Serologic Tests
chemical_list: D002699:Chlorambucil