Sympathomimetic amine-induced potentiation of fibrinolytic activity is partly modulated by endogenous prostaglandins in the rat.
Blood fibrinolytic activity was assessed on fibrin plates. Epinephrine and norepinephrine produced a time-dependent potentiation of fibrinolysis following intravenous injection into rats which was reduced by indomethacin (3 mg/kg, i.v.) and completely abolished by phentolamine (0.1 mg/kg, i.v.). Propranolol (0.5 mg/kg) had no effect on the fibrinolysis produced by epinephrine. The study demonstrates that endogenous prostaglandins modulate in part the fibrinolysis induced by sympathomimetic amines via activation of alpha-adrenoceptors in vivo.
Hussaini
I M
IM
Department of Chemistry, University of Virginia, Charlottesville 22901.
Moore
P K
PK
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D011453:Prostaglandins; D011433:Propranolol; D009638:Norepinephrine; D007213:Indomethacin; D004837:Epinephrine; D010646:Phentolamine