title: The histology of the eye after zosteriform spread of herpes simplex virus in the mouse.
abstract: A murine model of zosteriform spread of herpes simplex virus to the eye is reported. Viral antigens were demonstrated by a peroxidase-antiperoxidase technique in the trigeminal ganglion, iris, ciliary body, and cornea. The histology suggested a spontaneous bacterial superinfection during the later stages of the herpetic disease of the cornea. The relevance to human disease is discussed.
authors.affiliation: Department of Ophthalmology, University of Bristol, Medical School, UK.
authors.forename: C
authors.initials: C
authors.lastname: Claoue
authors.forename: T
authors.initials: T
authors.lastname: Hodges
authors.forename: T
authors.initials: T
authors.lastname: Hill
authors.forename: W
authors.initials: W
authors.lastname: Blyth
authors.forename: D
authors.initials: D
authors.lastname: Easty
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002924:Ciliary Body / Q000473:pathology; D003315:Cornea / Q000473:pathology; D004195:Disease Models, Animal; D005123:Eye / Q000276:immunology / Q000473:pathology*; D007498:Iris / Q000473:pathology; D007635:Keratitis, Dendritic / Q000276:immunology / Q000473:pathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018139:Simplexvirus / Q000276:immunology; D013997:Time Factors; D014276:Trigeminal Nerve / Q000473:pathology
chemical_list: D000956:Antigens, Viral