[Hormones and parturition in primates].
In primates, the endocrine signals which correlate with the end of gestation, i.e. account for fetal maturity, and initiate the parturition, i.e. trigger the myometrium contractility, remain unknown. Direct and indirect evidence supports the view that, as with domestic mammals, progesterone (or the estrogen/-progesterone ratio) plays a prominent role in inhibiting the contractility of the pregnant uterus. In the past few years an increasing number of endocrine factors have been identified in the placenta. They may contribute to the control of local or systemic steroid production but their effects are extraordinarily intermingled and it is impossible today to state whether any of them are relevant to the mechanism of parturition. The trophoblast and the myometrium establish close contact in the primate pregnancy. This is evidenced by histological studies and also by the influence of the proximity of the placenta on tissue steroid concentrations and the mechanisms of hormone coupling in the myometrium. Specific types or subtypes of myometrium hormone receptors are now well identified (e.g. to oxytocin, to catecholamines) and this now permits a better understanding of the role of their endogenous agonists in the course of parturition. However, such data are still lacking for other factors (e.g. prostanoids, VIP, relaxin...) involved to varying degrees in this process.
Germain
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INSERM, U. 262, Physiologie et Physiopathologie de la Reproduction, Maternité Baudelocque, Paris.
Ferre
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F
D000818:Animals; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000378:metabolism / Q000502:physiology*; D009215:Myometrium / Q000502:physiology; D010920:Placenta / Q000502:physiology; D010926:Placental Hormones / Q000302:isolation & purification / Q000502:physiology*; D011247:Pregnancy; D011323:Primates / Q000502:physiology*; D011453:Prostaglandins / Q000502:physiology; D017981:Receptors, Neurotransmitter / Q000502:physiology; D012065:Relaxin / Q000502:physiology; D013256:Steroids / Q000378:metabolism
D010926:Placental Hormones; D011453:Prostaglandins; D017981:Receptors, Neurotransmitter; D013256:Steroids; D012065:Relaxin
Hormones et parturition chez les primates.