title: Beta-globin gene polymorphism in Saudis: 5.6 Hpa I fragment.
abstract: To investigate beta-globin gene polymorphism in the Saudi population, samples from 436 individuals from the eastern and north-western provinces of Saudi Arabia were studied using restriction endonucleases Mst II and Hpa I. Three individuals with haemoglobin genotypes AA, AS and SS were identified to each have a 5.6-kilobase (kb) Hpa I fragment in addition to a 13.0-kb fragment. This paper reports for the first time in Saudis a linkage of both the beta A and beta B genes to a 5.6-kb Hpa I fragment.
authors.affiliation: College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: M A
authors.initials: MA
authors.lastname: el-Hazmi
authors.forename: A S
authors.initials: AS
authors.lastname: Warsy
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood / Q000235:genetics; D004262:DNA Restriction Enzymes; D015252:Deoxyribonucleases, Type II Site-Specific; D008040:Genetic Linkage; D005914:Globins / Q000235:genetics*; D006441:Hemoglobin A / Q000235:genetics; D006451:Hemoglobin, Sickle / Q000235:genetics; D006801:Humans; D010446:Peptide Fragments / Q000235:genetics / Q000302:isolation & purification; D010641:Phenotype; D011110:Polymorphism, Genetic; D012529:Saudi Arabia
chemical_list: D006451:Hemoglobin, Sickle; D010446:Peptide Fragments; D005914:Globins; D006441:Hemoglobin A; D004262:DNA Restriction Enzymes; C024406:endodeoxyribonuclease HpaI; D015252:Deoxyribonucleases, Type II Site-Specific