title: Influence of thyroid hormones and testosterone on the activities of hepatic mitochondrial enzymes in the Indian garden lizard, Calotes versicolor.
abstract: Thyroidectomy and castration in Calotes versicolor significantly decreased the activities of hepatic mitochondrial cytochrome oxidase, alpha-glycerophosphate dehydrogenase (alpha-GPDH), and succinate dehydrogenase (SDH) when compared to sham-operated controls. Administration of thyroid hormones in thyroidectomized lizards and testosterone in castrated specimens stimulated the activities of all three enzymes studied. Chloramphenicol, when injected with thyroxine prevented the hormone-stimulated activities of cytochrome oxidase and SDH, while actinomycin D and chloramphenicol, when administered along with testosterone propionate (low dose) prevented the testosterone-stimulated activities of cytochrome oxidase and alpha-GPDH.
authors.affiliation: Department of Zoology, University of Kerala, Trivandrum, India.
authors.forename: O V
authors.initials: OV
authors.lastname: Oommen
authors.forename: K K
authors.initials: KK
authors.lastname: Sreedeviamma
mesh_terms: D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D003576:Electron Transport Complex IV / Q000378:metabolism; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D008116:Lizards / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D009919:Orchiectomy; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013739:Testosterone / Q000494:pharmacology*; D013963:Thyroid Hormones / Q000494:pharmacology*; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology; D014284:Triiodothyronine / Q000494:pharmacology
chemical_list: D013963:Thyroid Hormones; D014284:Triiodothyronine; D003609:Dactinomycin; D013739:Testosterone; D002701:Chloramphenicol; D005993:Glycerolphosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D013974:Thyroxine