A new hamster model for adenoviral vaccination.
Both adult and baby hamsters infected intranasally with human adenovirus type 5 exhibited virologic, serologic, and histologic evidence of infection. When 8-day old hamsters were infected with 4 x 10(6) pfu, concentrations of virus up to 2 x 10(6) pfu/animal were detected in the lung, peaking on day 2. The minimum infectious dose was 1 x 10(3) pfu/animal. This model may be useful in studies of conventional and recombinant adenoviral vaccines for humans.
Hjorth
R N
RN
Wyeth Labs, Inc., Microbiology Division, Philadelphia, Pennsylvania.
Bonde
G M
GM
Pierzchala
W A
WA
Vernon
S K
SK
Wiener
F P
FP
Levner
M H
MH
Lubeck
M D
MD
Hung
P P
PP
D000257:Adenoviridae Infections / Q000276:immunology / Q000382:microbiology; D000258:Adenovirus Infections, Human / Q000276:immunology / Q000382:microbiology; D000260:Adenoviruses, Human / Q000276:immunology* / Q000502:physiology; D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D007422:Intestines / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D008647:Mesocricetus; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*; D014779:Virus Replication
D014614:Vaccines, Synthetic; D014765:Viral Vaccines