Intravascular synovial sarcoma.
A biphasic synovial sarcoma occurring in the wall of a pathologically thickened femoral vein was diagnosed in a 34-year-old woman. This sarcoma was resected together with removal of a thrombus. A local recurrence was seen 5 years later, but the patient is alive and well 11 years after the first operation. Immunohistochemical evaluation revealed cytokeratin and epithelial membrane antigen in a portion of the tumor cells, as are typically seen in synovial sarcoma. This case shows that so-called synovial sarcoma may arise in places remote from any joints and that its origin may not be a synovial or perisynovial tissue in all cases. More likely, synovial sarcomas develop from transformed mesenchymal cells, some of which have acquired the epithelial phenotype.
Miettinen
M
M
Department of Pathology, University of Helsinki, Finland.
Santavirta
S
S
Slätis
P
P
D000328:Adult; D005260:Female; D005268:Femoral Vein / Q000473:pathology* / Q000601:surgery; D006801:Humans; D009364:Neoplasm Recurrence, Local; D013584:Sarcoma, Synovial / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013927:Thrombosis / Q000150:complications