title: Catechol estrogen adducts.
abstract: Reaction of estrone-3,4-o-quinone with ethanethiol and glutathione leads to the formation of 4-hydroxyestrone-2-thioethers. Incubations of [1-3H]hydroxyestrone with rat liver microsomes and NADPH in the presence of glutathione results in the formation of 4-hydroxyestrone-S-glutathione with no release of tritium in the water indicating GSH addition to C-2 of 4-hydroxyestrone.
authors.affiliation: Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Abul-Hajj
authors.forename: P L
authors.initials: PL
authors.lastname: Cisek
mesh_terms: D000818:Animals; D002393:Estrogens, Catechol / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D006894:Hydroxyestrones / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D002393:Estrogens, Catechol; D006894:Hydroxyestrones; D013438:Sulfhydryl Compounds; C026418:4-hydroxyestrone; D009249:NADP; D005978:Glutathione; C007638:ethanethiol