[Superoxide-scavenging activity of carnosine in the presence of copper and zinc ions].
In the presence of Cu2+ and Zn2+ carnosine (beta-alanyl-L-histidine) possesses a superoxide-scavenging activity. The efficiency of scavenging as measured by the inhibition of tetrazolium nitroblue reduction in superoxide anion generation systems (phenazine methasulfate/NADH and xanthine/xanthine oxidase) is concentration-dependent and shows a maximum in the presence of millimolar concentrations of carnosine and equimolar concentrations of Cu2+ and Zn2+. In the presence of Cu2+ and Zn2+ histidine also exhibits a superoxide-scavenging activity. The feasible role of the superoxide-scavenging activity of histidine-containing dipeptide complexes with bivalent metal ions in the realization of physiological function of these dipeptides in skeletal muscles is discussed.
Guliaeva
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D001667:Binding, Competitive; D002336:Carnosine / Q000378:metabolism*; D003300:Copper / Q000378:metabolism*; D004151:Dipeptides / Q000378:metabolism*; D005609:Free Radicals; D006639:Histidine / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D009580:Nitroblue Tetrazolium; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism*
D004151:Dipeptides; D005609:Free Radicals; D013481:Superoxides; D009580:Nitroblue Tetrazolium; D006639:Histidine; D003300:Copper; D002336:Carnosine; D013482:Superoxide Dismutase; D015032:Zinc
Superoksidperekhvatyvaiushchaia aktivnost' karnozina v prisutstvii ionov medi i tsinka.