title: The duck beta-globin gene cluster contains a single enhancer element.
abstract: An erythroid-specific enhancer was previously identified in the 3'-flanking region of the beta adult gene in chicken and duck, by transfection into AEV transformed chicken erythroblasts. Here we show that the duck enhancer is equally active in erythroid human K562 cells, presenting an embryonic/fetal program of globin gene expression. Furthermore, no other enhancer was found within the 20 kb of DNA including four beta-like globin genes as well as a 1.5 kb upstream and a 3 kb downstream sequence.
authors.affiliation: Institut Jacques Monod, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Kretsovali
authors.forename: L
authors.initials: L
authors.lastname: Marcaud
authors.forename: M
authors.initials: M
authors.lastname: Huesca
authors.forename: K
authors.initials: K
authors.lastname: Scherrer
mesh_terms: D000818:Animals; D002460:Cell Line; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D004372:Ducks; D004742:Enhancer Elements, Genetic; D005796:Genes; D005914:Globins / Q000235:genetics*; D006801:Humans; D014162:Transfection
chemical_list: D005914:Globins; D004262:DNA Restriction Enzymes