Hypertensinogenic factors and renal alpha-adrenoceptors in young SHR and WKY rats.
The effects of high sodium intake (drinking 1% NaCl), DOCA and DOCA + 1%NaCl for 6 weeks on renal alpha 1- and alpha 2-adrenoceptors and on systolic blood pressure (SBP) were examined in young spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). On normal sodium intake, SHR rats had higher renal alpha 1 (p less than .001) and alpha 2-adrenoceptor densities (p less than .001) and SBP (p less than .001) than WKY rats. Although, WKY rats given either 1% NaCl, DOCA, and DOCA + 1% NaCl developed hypertension after 6 weeks of treatment, only 1% NaCl administration for the same period produced an increase in the alpha 1- and alpha 2-adrenoceptor densities when compared to the control (p less than .01 and p less than .001, respectively). In the SHR rats, to the contrary, ingestion of 1% NaCl and DOCA + 1% NaCl increased the already elevated alpha 2-adrenoceptor density (p less than .001) and SBP even more in this strain after 6 weeks of treatment. Equilibrium dissociation constants (KD), however, were similar for both classes of receptors in experimental and control rats. This study indicates that postweaning exposure of the WKY and SHR rats to a high salt treatment and DOCA can influence the renal alpha-adrenoceptor densities. Although the functional significance of the changes is unclear, it is reasonable to speculate that postweaning exposure to a hypertensinogenic stimuli such as a 1% NaCl and/or DOCA may ultimately interfere with the functional development of the kidney differently in rats genetically predisposed to hypertension (SHR) from normotensive (WKY) rats.
Sáiz
J
J
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Córdoba, Spain.
Lara
B
B
Torres
A
A
Sánchez
A
A
D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D003900:Desoxycorticosterone / Q000494:pharmacology*; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000254:growth & development; D008297:Male; D011224:Prazosin / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000378:metabolism; D012982:Sodium, Dietary / Q000494:pharmacology*; D015016:Yohimbine / Q000378:metabolism
D011942:Receptors, Adrenergic, alpha; D012982:Sodium, Dietary; D015016:Yohimbine; D003900:Desoxycorticosterone; D011224:Prazosin