MK-801 blocks NMDA receptor-mediated synaptic transmission and long term potentiation in rat hippocampal slices.
The effect of the anticonvulsant and neuroprotective agent (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine maleate (MK-801) has been studied on synaptic events in the CA1 region of rat hippocampal slices. MK-801 blocked selectively the N-methyl-D-aspartate receptor-mediated component of synaptic transmission, which can be recorded in response to single shock stimulation of the Schaffer collateral-commissural pathway in the absence of added Mg2+ to the perfusate. MK-801 also prevented the induction of long term potentiation, which is normally produced in this pathway by high frequency stimulation in the presence of Mg2+.
Coan
E J
EJ
Department of Pharmacology, Medical School, University of Bristol, U.K.
Saywood
W
W
Collingridge
G L
GL
D000818:Animals; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D005260:Female; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D013569:Synapses / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*
D003986:Dibenzocycloheptenes; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D016291:Dizocilpine Maleate