Pharmacokinetics of pralidoxime chloride. A comparative study in healthy volunteers and in organophosphorus poisoning.
The pharmacokinetics of a cholinesterase reactivating oxime, 2-PAM, was comparatively studied in healthy volunteers and in persons suffering from poisoning by organophosphorus insecticides. The elevation of plasma concentrations of the oxime and prolongation of its "effective half-life" were noticed in poisoned individuals. These changes were attributed to the disturbed general hemodynamics and reduced renal blood flow in organophosphorus intoxication rather than to the direct renal toxicity of anticholinesterases.
Jovanović
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Military Technical Institute, Medical Department, Belgrade, Yugoslavia.
D006207:Half-Life; D006801:Humans; D062025:Organophosphate Poisoning; D011220:Pralidoxime Compounds / Q000493:pharmacokinetics*
D011220:Pralidoxime Compounds