The effect of thiamin supplementation on the thiamin status of turkey poults with ethanol-induced cardiomegaly.
1. Turkey poults were treated with graded doses (0-5% v/v) of ethanol for 6 weeks. Some birds were concomitantly injected intramuscularly with thiamin. 2. Erythrocyte transketolase (TK) activity was significantly decreased and the erythrocyte pyrophosphate (TPP) effect and blood concentrations of lactate and pyruvate were statistically greater in all ethanol-treated poults by 42 days. 3. Thiamin restored TK activity to normal levels and decreased the TPP effect and blood concentrations of lactate and pyruvate in ethanol poults. 4. Thiamin mitigated ethanol-induced cardiomyopathy in some 4-5% ethanol poults. 5. Thiamin had no significant effect on any of these parameters in control birds treated with thiamin.
Ali
B H
BH
Department of Veterinary Medicine, Pharmacology and Toxicology, Faculty of Veterinary Science, University of Khartoum, Sudan.
Czarnecki
C M
CM
D000818:Animals; D006332:Cardiomegaly / Q000139:chemically induced / Q000517:prevention & control*; D011756:Diphosphates / Q000097:blood; D000431:Ethanol / Q000037:antagonists & inhibitors*; D007773:Lactates / Q000097:blood; D011773:Pyruvates / Q000097:blood; D013831:Thiamine / Q000494:pharmacology*; D014174:Transketolase / Q000097:blood; D014422:Turkeys
D011756:Diphosphates; D007773:Lactates; D011773:Pyruvates; D000431:Ethanol; D014174:Transketolase; D013831:Thiamine