title: Macrophages specifically regulate the concentration of their own growth factor in the circulation.
abstract: The physiological mechanism of clearance of the mononuclear phagocyte growth factor, colony-stimulating factor 1 (CSF-1), from the circulation of normal mice was investigated by following the fate of a trace amount of i.v. injected 125I-labeled CSF-1. Macrophages selectively cleared CSF-1 by CSF-1 receptor-mediated endocytosis and degraded the growth factor intracellularly. This manner of clearance provides a feedback control mechanism whereby the rate of macrophage production is determined by the number of mature macrophages.
authors.forename: A
authors.initials: A
authors.lastname: Bartocci
authors.forename: D S
authors.initials: DS
authors.lastname: Mastrogiannis
authors.forename: G
authors.initials: G
authors.lastname: Migliorati
authors.forename: R J
authors.initials: RJ
authors.lastname: Stockert
authors.forename: A W
authors.initials: AW
authors.lastname: Wolkoff
authors.forename: E R
authors.initials: ER
authors.lastname: Stanley
mesh_terms: D000818:Animals; D003115:Colony-Stimulating Factors / Q000378:metabolism*; D004705:Endocytosis; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D011956:Receptors, Cell Surface / Q000378:metabolism; D016184:Receptors, Colony-Stimulating Factor
chemical_list: D003115:Colony-Stimulating Factors; D011956:Receptors, Cell Surface; D016184:Receptors, Colony-Stimulating Factor