Feline mammary carcinomas as a model for human breast cancer. II. Comparison of in vivo and in vitro adriamycin sensitivity.
Feline mammary carcinomas were tested for their in vitro and in vivo sensitivity to Adriamycin. In vitro, twenty randomly chosen tumor islands were studied to test the effect of concentrations of the drug ranging from 0.25-2.00 micrograms/ml. In vivo, parts of primary tumors left in situ after surgical biopsy were used to assess the response to five i.v. injections of 30 mg/m2 Adriamycin. When comparing the in vitro and in vivo response, the best sensitivity (100%) was obtained using 2.00 micrograms/ml Adriamycin and the best specificity (75%) using 1.00 microgram/ml Adriamycin, both in vitro. Tumors recurring after treatment showed acquired resistance in vitro.
Stolwijk
J A
JA
Department of Pathology, Faculty of Veterinary Medicine, State University, Utrecht, The Netherlands.
Minke
J M
JM
Rutteman
G R
GR
Hoekstra
J
J
Prop
F J
FJ
Misdorp
W
W
D000232:Adenofibroma / Q000188:drug therapy; D000236:Adenoma / Q000188:drug therapy; D000818:Animals; D002277:Carcinoma / Q000188:drug therapy; D002415:Cats; D046508:Culture Techniques / Q000379:methods; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000494:pharmacology / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy*; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects*
D004317:Doxorubicin