Treatment of Clostridium difficile colitis in hamsters with a lipopeptide antibiotic, LY146032.
LY146032, an acidic lipopeptide antibiotic which inhibits the biosynthesis of cell wall peptidoglycan, was found to be effective in delaying death in a hamster model of pseudomembranous colitis. A dose of 0.05 mg/day was effective. The equivalent protection with vancomycin required a dose 100-fold higher, i.e., 5 mg/day.
Dong
M Y
MY
Department of Community Health, Tufts University School of Medicine, Boston, Massachusetts 02111.
Chang
T W
TW
Gorbach
S L
SL
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002981:Clindamycin / Q000009:adverse effects; D006224:Cricetinae; D017576:Daptomycin; D004195:Disease Models, Animal; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy*; D008297:Male; D008647:Mesocricetus; D010455:Peptides / Q000627:therapeutic use; D014640:Vancomycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D010455:Peptides; D002981:Clindamycin; D014640:Vancomycin; D017576:Daptomycin