[Free radical mechanism of homogentisic acid in alkaptonuria].
Non-enzymatic oxidation in alkaline media of homogentisinic acid, excreted with urine in alkaptonuria, involved free radical mechanism. The oxidative process was accompanied by production of superoxide anion O2- and required metal cations. Free radical destruction of cells and biopolymers via O2- or homogentisinic acid semiquinone appears to be one of pathogenetic mechanisms responsible for impairment of connective tissue structures in patients with alkaptonuria.
Gerasimov
A M
AM
Zakharov
A S
AS
D000474:Alkaptonuria / Q000378:metabolism* / Q000652:urine; D003574:Cytochrome c Group / Q000378:metabolism; D005609:Free Radicals; D006713:Homogentisic Acid / Q000378:metabolism* / Q000652:urine; D006801:Humans; D007700:Kinetics; D010084:Oxidation-Reduction
D003574:Cytochrome c Group; D005609:Free Radicals; D006713:Homogentisic Acid
Svobodnoradikal'nyĭ mekhanizm okisleniia gomogentizinovoĭ kisloty pri alkaptonurii.