title: Changes in plasma vitamin levels in the first 48 hours after onset of acute myocardial infarction.
abstract: To establish whether plasma vitamin measurements made after acute myocardial infarction (AMI) can be used in case-control studies of coronary artery disease, the short-term effect of AMI on plasma concentrations of 25-hydroxyvitamin D3, beta-carotene, vitamin E and retinol was investigated. Sequential measures of these vitamins were made during the first 48 hours after AMI in 13 patients admitted to the hospital within 4 hours after the onset of symptoms. Plasma levels of 25-hydroxyvitamin D did not change significantly during the first 12 hours after onset of symptoms. Beta-carotene levels increased significantly (p less than 0.05) during the first 12 hours and then decreased, whereas levels of vitamin E and retinol progressively decreased during the first 48 hours by 26 and 25%, respectively. These results suggest that, of these vitamins, only plasma measurements of 25-hydroxyvitamin D3 collected within 12 hours of onset of symptoms may provide reliable information for case-control studies of AMI.
authors.affiliation: Department of Community Health, University of Auckland, New Zealand.
authors.forename: R
authors.initials: R
authors.lastname: Scragg
authors.forename: R
authors.initials: R
authors.lastname: Jackson
authors.forename: I
authors.initials: I
authors.lastname: Holdaway
authors.forename: G
authors.initials: G
authors.lastname: Woollard
authors.forename: D
authors.initials: D
authors.lastname: Woollard
mesh_terms: D000368:Aged; D002112:Calcifediol / Q000097:blood; D002338:Carotenoids / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D013997:Time Factors; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood; D014815:Vitamins / Q000097:blood*; D019207:beta Carotene
chemical_list: D014815:Vitamins; D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E; D002338:Carotenoids; D002112:Calcifediol