Cocaine binding at sigma receptors.
Cocaine and some related psychostimulants interact with sigma receptors in binding assays. Their Ki values are compatible with blood concentrations reported to produce psychosis in human volunteers. It is proposed that the psychotomimetic effects of some psychostimulants may derive, at least in part, from their interaction with sigma receptors.
Sharkey
J
J
Neuroscience Branch, NIDA Addiction Research Center, Baltimore, MD 21224.
Glen
K A
KA
Wolfe
S
S
Kuhar
M J
MJ
D000818:Animals; D001667:Binding, Competitive; D002531:Cerebellum / Q000378:metabolism; D003042:Cocaine / Q000378:metabolism*; D006220:Haloperidol / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000378:metabolism*; D017480:Receptors, sigma
D011957:Receptors, Opioid; D017480:Receptors, sigma; D003042:Cocaine; D006220:Haloperidol