title: Effects of ZSY-27, a synthesized phosphodiesterase inhibitor, on exocrine secretion and cyclic nucleotide concentration in the dog pancreas.
abstract: 1. Effects of intravenous injections of ZSY-27, a synthesized phosphodiesterase inhibitor, on pancreatic exocrine secretion and on pancreatic cyclic AMP and cyclic GMP concentrations of dogs were investigated. 2. ZSY-27 (0.3 and 1 mg/kg) increased cyclic AMP concentration dose-dependently, which preceded the increase in pancreatic secretion but did not affect cyclic GMP concentration. 3. These results suggest that ZSY-27 causes exocrine secretion from the dog pancreas mediated through an increase in intracellular cyclic AMP concentration.
authors.affiliation: Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Iwatsuki
authors.forename: A
authors.initials: A
authors.lastname: Horiuchi
authors.forename: S
authors.initials: S
authors.lastname: Chiba
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004285:Dogs; D005260:Female; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D013843:Thiazines / Q000494:pharmacology*
chemical_list: D010726:Phosphodiesterase Inhibitors; D013843:Thiazines; C050142:ZSY 27; D000242:Cyclic AMP; D006152:Cyclic GMP