Characterization of a human lymphoblastoid cell line permanently modified by simian foamy virus type 10.
Simian Spumavirinae serotype, SFV10, of a Papio cynocephalus baboon, was used to infect a human lymphoblastoid cell line, LV2. Permanent growth and morphological alterations of infected cells occurred, even though no viral particles were detected. Evidence for the presence of viral genomes in the modified cell line is provided indirectly from immunological studies and induction experiments followed by coculture procedures. The permanently modified cell line obtained (LV2-FB10) is an interesting model for the investigation of the possible integration of foamy viruses into the host genomes.
Rhodes-Feuillette
A
A
Laboratoire de Recherche sur l'Immunomodulation, Hôpital Saint-Louis, Paris, France.
Mahouy
G
G
Lasneret
J
J
Flandrin
G
G
Peries
J
J
D000818:Animals; D002461:Cell Line, Transformed; D002472:Cell Transformation, Viral; D005814:Genes, Viral; D006801:Humans; D010215:Papio / Q000382:microbiology*; D012190:Retroviridae / Q000472:pathogenicity*; D016092:Spumavirus / Q000235:genetics / Q000472:pathogenicity*