Changes in human plasma essential fatty acid levels as a result of administration of linoleic acid and gamma-linolenic acid.
Administration of doses of linoleic acid (LA) up to 36 g/d in humans raised blood levels of linoleic acid but not of its metabolites. This is probably because the conversion of LA to gamma-linolenic acid (GLA) is slow and rate-limiting. We have found that administration of relatively small amounts of GLA, up to 360 mg/d, raises human blood levels of dihomogammalinolenic acid (DGLA) and arachidonic acid (AA).
Manku
M S
MS
Efamol Research Institute, Kentville, Nova Scotia, Canada.
Morse-Fisher
N
N
Horrobin
D F
DF
D000328:Adult; D005228:Fatty Acids, Essential / Q000097:blood*; D005260:Female; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology*; D008042:Linolenic Acids / Q000494:pharmacology*; D008297:Male; D017965:gamma-Linolenic Acid
D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D008042:Linolenic Acids; D017965:gamma-Linolenic Acid; D019787:Linoleic Acid