title: Long-term treatment with chlorthalidone reduces experimental hydrops but does not prevent the hearing loss.
abstract: Long-term treatment of guinea pigs with the diuretics chlorthalidone and acetazolamide, following the experimental obstruction of the endolymphatic duct, was assessed using chronically implanted round window cochlear electrodes. The diuretic chlorthalidone appeared to curb the progressive low-frequency sensitivity loss during the first 4 weeks following surgery, as compared with animals receiving the diuretic acetazolamide or no treatment. However, this apparent beneficial effect decreased after 4 weeks and was not apparent at 14 weeks post-induction. On the other hand, morphological control at the end of 14 weeks confirmed a marked reduction in hydrops in the chlorthalidone-treated animals. The data clearly demonstrate a dissociation between hydrops and the development of hearing loss and suggest that the augmenting endolymph volume is only one of several contributing factors to the deteriorating auditory function in experimental hydrops.
authors.affiliation: Laboratoire d'Audiologie Expérimentale, Inserm Unité 229, Université Bordeaux II, Hôpital Pellegrin, France.
authors.forename: K C
authors.initials: KC
authors.lastname: Horner
authors.forename: C
authors.initials: C
authors.lastname: Aurousseau
authors.forename: J P
authors.initials: JP
authors.lastname: Erre
authors.forename: Y
authors.initials: Y
authors.lastname: Cazals
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use; D000818:Animals; D001300:Audiometry, Evoked Response; D002752:Chlorthalidone / Q000627:therapeutic use*; D004710:Endolymph / Q000502:physiology; D004711:Endolymphatic Duct; D006168:Guinea Pigs; D034381:Hearing Loss / Q000517:prevention & control*; D008575:Meniere Disease / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000086:Acetazolamide; D002752:Chlorthalidone