title: Perianal adenomas and hypertestosteronemia in a spayed bitch with pituitary-dependent hyperadrenocorticism.
abstract: Hypertestosteronemia was diagnosed in a spayed bitch with pituitary-dependent hyperadrenocorticism and perianal adenomas. Serum concentrations of cortisol and testosterone decreased after treatment with mitotane was instituted. Excessive testosterone in this dog was thought to have been produced by the adrenal cortex, possibly in response to excessive ACTH concentrations. Development of androgen- or estrogen-responsive tumors in castrated dogs may be an early indication of adrenocortical hyperfunction.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
authors.forename: S W
authors.initials: SW
authors.lastname: Dow
authors.forename: P N
authors.initials: PN
authors.lastname: Olson
authors.forename: R A
authors.initials: RA
authors.lastname: Rosychuk
authors.forename: S J
authors.initials: SJ
authors.lastname: Withrow
mesh_terms: D000236:Adenoma / Q000150:complications / Q000601:surgery / Q000662:veterinary*; D000308:Adrenocortical Hyperfunction / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone; D000694:Anal Gland Neoplasms / Q000150:complications / Q000601:surgery / Q000662:veterinary*; D000818:Animals; D003452:Cryosurgery / Q000662:veterinary; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D008939:Mitotane / Q000627:therapeutic use; D010052:Ovariectomy / Q000662:veterinary; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone; D008939:Mitotane; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone