Nuclear magnetic resonance studies on malignant fibrous histiocytoma--evaluation of the effectiveness of chemotherapy in anticancer drug.
The relaxation times of water protons in the tissues of malignant fibrous histiocytoma (MFH) and the tumor treated with adriamycin (adriamycin-treated MFH) were studied in rats as a model of human MFH by nuclear magnetic resonance. Using the values of the malignancy index derived from the relaxation times of these tumors, it has been possible to discriminate clearly between MFH tissue and non-malignant tissue, and to evaluate the effectiveness of anticancer drug. The malignancy index, furthermore, was compatible with the histological evaluation of the effectiveness of chemotherapy in an adriamycin-treated malignant fibrous histiocytoma.
Shimomura
Y
Y
Department of Orthopaedic Surgery, Kumamoto University Medical School, Japan.
Yamasaki
M
M
D000818:Animals; D004317:Doxorubicin / Q000627:therapeutic use*; D004341:Drug Evaluation; D018219:Histiocytoma, Benign Fibrous / Q000188:drug therapy* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains
D004317:Doxorubicin