[Epilepsy and endocrine modifications].
From a few personal works and from a review of the literature, the authors discuss the current date of the endocrinological involvement of epileptic seizures, epileptic diseases, and anticonvulsants. Generalized epileptic seizures are followed by a constant, specific and significant rise of ACTH and Prolactin during the hour after the fit. That is a very good biological marker of the epileptic cause of a loss of consciousness. The duration and the repetition of the seizures involve the pituitary-gonadotropic+ axis that explains the anovulatory cycles and hypofertility in women, and the decrease of libido in men. Then, the anticonvulsants involve the hormonal balance, either by a direct action upon the hypothalamo-pituitary axis (ACTH, Prolactin) or by a direct action upon peripheral hormones (Testosterone, Thyroxine). These problems must be known for the follow-up of the epileptic patients, and for the interpretation of the hormonal dosage of these patients.
Giroud
M
M
Service de Neurologie, Centre Hospitalier Régional et Universitaire, Dijon.
Dumas
R
R
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000858:Anovulation / Q000503:physiopathology; D000927:Anticonvulsants / Q000494:pharmacology; D004827:Epilepsy / Q000503:physiopathology*; D005260:Female; D006728:Hormones / Q000502:physiology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007247:Infertility, Female / Q000503:physiopathology; D008297:Male; D011388:Prolactin / Q000097:blood
D000927:Anticonvulsants; D006728:Hormones; D000324:Adrenocorticotropic Hormone; D011388:Prolactin
Epilepsie et modifications endocriniennes.