Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity.
Culbertson
T P
TP
Warner-Lambert/Parke-Davis Research, Ann Arbor, MI 48105.
Domagala
J M
JM
Nichols
J B
JB
Priebe
S
S
Skeean
R W
RW
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D005260:Female; D024841:Fluoroquinolones; D051379:Mice; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D011804:Quinolines; D059005:Topoisomerase II Inhibitors; C047718:CI 934