Norepinephrine-elicited accumulation of cyclic AMP in slices of rat cerebral cortex polarized with a weak anodal current.
Cyclic AMP accumulation in response to norepinephrine was examined in slices of rat cerebral cortex the day after a unilateral application of anodal current of 0.3, 3.0 or 30 microA to the surface of the sensorimotor cortex. When 3.0 microA was applied, the norepinephrine-elicited accumulation of cyclic AMP was greater in the cortical area including the application point than in either the contralateral cortical area or non-polarized control cortical slices. The changes in cyclic AMP accumulation are discussed in relation to the role of the direct current in producing functional changes in the cortex.
Moriwaki
A
A
Department of Physiology, Okayama University Medical School, Japan.
Hattori
Y
Y
Hayashi
Y
Y
Kusai
Y
Y
Hori
Y
Y
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains
D000242:Cyclic AMP; D009638:Norepinephrine