[Aldosterone content of the blood and tissues in rats with an altered level of adrenergic activity].
The content of aldosterone (A) was studied in rat adrenal glands, blood plasma and peripheral tissues--in the myocardium, skeletal muscles, thymus and liver--1 h after the administration of alpha-adrenergic stimulator noradrenaline and beta-adrenergic stimulator isoprenaline and after simultaneous administration of alpha- and beta-blockers and a sympatholytic agent (pyrroxan, propranolol and bretylium tosylate respectively). Adrenergic stimulation did not change the level of A in the adrenal glands, raised its blood concentration and, to a greater extent, its level in the peripheral tissues. A marked increase in the blood concentration of A resulted from isoprenaline and its accumulation in tissues--from noradrenaline. A decrease in the level of adrenergic activity considerably lowered the A content in the adrenal glands, blood plasma and peripheral tissues excluding the myocardium where this value was higher than in the blood.
Korovin
K F
KF
Kovalev
O A
OA
Iampol'skaia
L I
LI
Samokhin
G S
GS
D000311:Adrenal Glands / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D000450:Aldosterone / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D001950:Bretylium Tosylate / Q000494:pharmacology; D004146:Dioxanes / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011863:Radioimmunoassay; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D004146:Dioxanes; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D000450:Aldosterone; D001950:Bretylium Tosylate; D011433:Propranolol; D007545:Isoproterenol; C009143:proroxan; D009638:Norepinephrine
Soderzhanie al'dosterona v krovi i tkaniakh krys pri izmenenii urovnia adrenergicheskoĭ aktivnosti.