[Effect of the dopamine agonist parlodel on steroid hormone secretion and their metabolism in the liver].
Experiments on rats have shown that the dopamine agonist parlodel produces a noticeable inhibitory effect on function of the pituitary-adrenal system by a decrease in corticotropin secretion and direct influence on aldosterone synthesis and secretion. Changes in corticosterone level caused by parlodel are related to ACTH action and inhibition of activity of the microcirculatory bed of the adrenal fascicular zone. The dopamine agonist parlodel produces no effect on metabolism of the steroid hormones: corticosterone and testosterone in the rat hepatic tissue.
Valueva
G V
GV
Tron'ko
N D
ND
Slavnov
V N
VN
Iakovlev
A A
AA
Luchitskiĭ
E V
EV
D000311:Adrenal Glands / Q000187:drug effects / Q000648:ultrastructure; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D003345:Corticosterone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000378:metabolism; D013997:Time Factors
D001971:Bromocriptine; D013739:Testosterone; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone
Vliianie agonista dofamina parlodela na sekretsiiu steroidnykh gormonov i ikh obmen v pecheni.