title: Possible association of specific HLA haplotype in a pedigree with familial polyposis coli.
abstract: HLA-A, -B, -C, and -DR typing was performed in a pedigree with familial polyposis coli (FPC). Three living members with FPC and one member without obvious FPC had the same HLA haplotype; A24(9)-B51-X-DRw8 (X indicates undetected HLA-C locus). It was genetically deduced that a deceased member with FPC also had this haplotype. No other members had this haplotype. No association was found between FPC and other HLA haplotypes. Thus an association between the specific HLA haplotype and FPC was suspected in this family.
authors.forename: Y
authors.initials: Y
authors.lastname: Nagatomo
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Kodama
authors.forename: H
authors.initials: H
authors.lastname: Kambe
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D000328:Adult; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree
chemical_list: D006680:HLA Antigens