Coxsackie virus infection in association with heart affection in man.
The frequency of actual infections by selected types of coxsackie virus (B1-B6, A7, A9) has been followed up in adult patients hospitalized for reason of heart disease. Criteria of actual coxsackie virus infection have been defined, including a significant rise of titer of virus neutralizing antibodies and/or presence of virus-specific IgM antibodies. An actual coxsackie virus infection has been found in 71 (46.3%) out of 153 patients. Most frequently coxsackie B1 virus infection (24 times) and B4 (17 times) could be proved. In sera of patients with actual coxsackie virus infection, a higher proportion of infection with some types of coxsackie viruses, along with the presence of antibodies against a larger number of coxsackie virus types has been found, as compared to sera from patients without actual coxsackie virus infection, and/or, in sera of healthy blood donors (control group). The role of repeated infections with different types of coxsackie virus in the etiology of heart disease has been discussed.
Petrovicová
A
A
Research Institute of Preventive Medicine, Bratislava, Czechoslovakia.
Cervenka
J
J
Egnerová
A
A
D000914:Antibodies, Viral / Q000032:analysis; D003384:Coxsackievirus Infections / Q000150:complications*; D029822:Enterovirus B, Human / Q000276:immunology; D006331:Heart Diseases / Q000209:etiology*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D009500:Neutralization Tests
D000914:Antibodies, Viral; D007075:Immunoglobulin M