title: Evidence for the presence of cytochrome P-450 in mastitic bovine mammary gland.
abstract: The content of cytochrome P-450 in mastitic and healthy lactating bovine mammary gland was analyzed. Evidence for the existence of cytochrome P-450 in mastitic tissues was found. The amount of cytochrome P-450 formed in the assay ranged from 0.017 to 0.031 nmole/mg protein. The highest concentrations were found in severely inflamed samples, whereas and traces or no cytochrome P-450 were found in healthy tissues. The significance of cytochrome P-450 in mastitic mammary gland is discussed in relation to host defence involving oxidative killing of pathogens.
authors.affiliation: Department of Pharmacology & Toxicology, College of Veterinary Medicine, Helsinki, Finland.
authors.forename: F
authors.initials: F
authors.lastname: Atroshi
authors.forename: P
authors.initials: P
authors.lastname: Kaipainen
authors.forename: J
authors.initials: J
authors.lastname: Parantainen
mesh_terms: D000818:Animals; D002248:Carbon Monoxide; D002417:Cattle; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis*; D005260:Female; D005609:Free Radicals; D005978:Glutathione / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000201:enzymology*; D008414:Mastitis, Bovine / Q000201:enzymology*; D008861:Microsomes / Q000201:enzymology; D013481:Superoxides / Q000378:metabolism
chemical_list: D005609:Free Radicals; D013481:Superoxides; D002248:Carbon Monoxide; D003577:Cytochrome P-450 Enzyme System; D005978:Glutathione