title: Selective intestinal decontamination of the digestive tract for infection prophylaxis in severely burned patients.
abstract: An oral prophylactic antibiotic regimen aiming at suppression of the gram-negative rods and yeasts of the bowel flora was utilised in 48 severely burned patients to prevent burn wound colonisation. Only 17% of the patients had an actual or potential infection. Only one Pseudomonas infection occurred. The effect of this selective gastro-intestinal decontamination is discussed.
authors.affiliation: Laboratory for Public Health, Groningen, The Netherlands.
authors.forename: W L
authors.initials: WL
authors.lastname: Manson
authors.forename: A W
authors.initials: AW
authors.lastname: Westerveld
authors.forename: H J
authors.initials: HJ
authors.lastname: Klasen
authors.forename: E W
authors.initials: EW
authors.lastname: Sauër
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002056:Burns / Q000150:complications*; D004064:Digestive System / Q000382:microbiology*; D004338:Drug Combinations / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D011113:Polymyxins / Q000008:administration & dosage; D013420:Sulfamethoxazole / Q000008:administration & dosage; D014031:Tobramycin / Q000008:administration & dosage; D014295:Trimethoprim / Q000008:administration & dosage; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014946:Wound Infection / Q000517:prevention & control*
chemical_list: D000890:Anti-Infective Agents; D004338:Drug Combinations; D011113:Polymyxins; D000666:Amphotericin B; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole; D014031:Tobramycin