Interaction of neuromediator and immunoglobulin receptors of mice B-lymphocytes.
The effect of rabbit antiserum to mice globulins on the M-cholinergic receptors (M-ChR) expression of spleen B-lymphocytes of CBA and Balb/c mice has been studied. Anti-globulin antiserum depending on its concentration decreased M-Chr expression on B-lymphocytes intact animals both species. The anti-globulin serum effect appeared to be maximal at 37 degrees C and minimal at 4 degrees C. The date obtained suggests a possible interaction between the immunoglobulin (antigen binding) and the neuromediator receptors of B-lymphocytes which may appear to be one of the mechanisms of interrelationship of the nervous and immune system at the cellular level.
Ado
A D
AD
Institute of Immunology, USSR Ministry of Health, Moscow.
Goldshtein
M M
MM
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D005260:Female; D007107:Immune System / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D009424:Nervous System Physiological Phenomena; D011813:Quinuclidinyl Benzilate; D011971:Receptors, Immunologic / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism*; D013154:Spleen / Q000166:cytology
D000888:Antibodies, Anti-Idiotypic; D011971:Receptors, Immunologic; D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate