title: [Demonstration of an inoculum effect on the estimation of the minimal inhibitory concentration of LY 146032].
abstract: This work has been performed to study the inoculum effect on the in vitro activity of LY 146032, a new lipopeptide antibiotic. A statistical analysis (X2 and t test) of the data concerning the MIC of different bacterial groups has been carried out to appreciate the phenomenon. The activity of vancomycin has been compared. A major inoculum effect has been detected for LY 146032. It must be taken into account to evaluate the activity of this new antibiotic.
authors.affiliation: Faculté de Médecine Lyon Sud, Laboratoire de Bactériologie, Hôtel-Dieu.
authors.forename: J P
authors.initials: JP
authors.lastname: Flandrois
authors.forename: G
authors.initials: G
authors.lastname: Carret
authors.forename: C
authors.initials: C
authors.lastname: Pichat
authors.forename: M
authors.initials: M
authors.lastname: Peyret
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001431:Bacteriological Techniques; D017576:Daptomycin; D013293:Enterococcus faecalis / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013292:Streptococcus agalactiae / Q000187:drug effects; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; D014640:Vancomycin; D017576:Daptomycin
vernacular_title: Mise en évidence d'un effet inoculum sur l'estimation de la concentration minimale inhibitrice du LY 146032.