title: Transplantation resistance to a Rous sarcoma virus-induced tumor in mice immunized with v-src protein.
abstract: It is of great interest in tumor immunology to know whether oncogene products could be used not only as tumor markers for cancer diagnosis, but also as immunogens for cancer therapy. BALB/c mice immunized with syngeneic fibroblasts, Escherichia coli cells producing p60v-src, or the purified p60v-src protein extracted from the E. coli producer cells showed transplantation resistance to a Rous sarcoma virus-induced tumor but not a Kirsten sarcoma virus-induced tumor. In contrast, mice immunized with cells not producing p60v-src or their derived proteins or with chicken ovalbumin did not show any significant resistance. These findings suggest that p60v-src can act as a specific transplantation rejection antigen in mice.
authors.affiliation: Laboratory of Molecular Genetics, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kuzumaki
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: H
authors.initials: H
authors.lastname: Dosaka
authors.forename: M
authors.initials: M
authors.lastname: Katabami
authors.forename: A D
authors.initials: AD
authors.lastname: Levinson
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D000957:Antigens, Viral, Tumor / Q000276:immunology; D006649:Histocompatibility Antigens / Q000276:immunology; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D015688:Oncogene Protein pp60(v-src); D012191:Retroviridae Proteins / Q000276:immunology*; D001357:Sarcoma, Avian / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm; D000957:Antigens, Viral, Tumor; D006649:Histocompatibility Antigens; D012191:Retroviridae Proteins; C029237:tumor-associated transplantation antigen; D015688:Oncogene Protein pp60(v-src)