Treatment of cytomegalovirus gastrointestinal ulceration in a heart transplant patient.
A 62-year-old man developed cytomegalovirus gastrointestinal infection associated with moderate cardiac rejection. The patient was successfully treated with a new therapeutic agent 9-(1,3-dihydroxy-2-proproxymethyl) guanine during maximal immunosuppression. The medication was well-tolerated, and the patient had an excellent response to therapy. We believe this has significant implications for cytomegalovirus-induced gastrointestinal disease in the heart transplant patient.
Sinnott
J T
JT
Division of Infectious and Tropical Diseases, University of South Florida College of Medicine, Tampa 33612.
Cullison
J P
JP
Rogers
K
K
D000212:Acyclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy; D015774:Ganciclovir; D005767:Gastrointestinal Diseases / Q000209:etiology*; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D014456:Ulcer / Q000209:etiology*
D000998:Antiviral Agents; D015774:Ganciclovir; D000212:Acyclovir