Sulfur oxidation of free methionine by oxygen free radicals.
The oxidation of free methionine to methionine sulfoxide by chemically or enzymatically generated oxygen free radicals is presented. The physiological significance of this process in living cells is suggested.
Scislowski
P W
PW
Department of Biochemistry, Indiana University School of Medicine, Indianapolis 46223.
Davis
E J
EJ
D000818:Animals; D002374:Catalase / Q000378:metabolism; D005609:Free Radicals; D008715:Methionine / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000378:metabolism; D009211:Myoglobin / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D013455:Sulfur / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
D005609:Free Radicals; D009211:Myoglobin; C017595:oxymyoglobin; D009243:NAD; D013481:Superoxides; D013455:Sulfur; D008715:Methionine; D002374:Catalase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D010100:Oxygen; C013111:methionine sulfoxide