[Demonstration of an inoculum effect on the estimation of the minimal inhibitory concentration of LY 146032].
This work has been performed to study the inoculum effect on the in vitro activity of LY 146032, a new lipopeptide antibiotic. A statistical analysis (X2 and t test) of the data concerning the MIC of different bacterial groups has been carried out to appreciate the phenomenon. The activity of vancomycin has been compared. A major inoculum effect has been detected for LY 146032. It must be taken into account to evaluate the activity of this new antibiotic.
Flandrois
J P
JP
Faculté de Médecine Lyon Sud, Laboratoire de Bactériologie, Hôtel-Dieu.
Carret
G
G
Pichat
C
C
Peyret
M
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001431:Bacteriological Techniques; D017576:Daptomycin; D013293:Enterococcus faecalis / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013292:Streptococcus agalactiae / Q000187:drug effects; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010455:Peptides; D014640:Vancomycin; D017576:Daptomycin
Mise en évidence d'un effet inoculum sur l'estimation de la concentration minimale inhibitrice du LY 146032.