title: Biologically-significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by some anti-inflammatory drugs.
abstract: Neutrophils contain the enzyme myeloperoxidase, which oxidizes Cl- ions into the powerful oxidant hypochlorous acid (HOCl). HOCl inactivates alpha 1-antiprotease, permitting uncontrolled protease activities. Most anti-inflammatory drugs tested are capable of reacting with HOCl, but the reactions seem insufficiently rapid under physiological conditions to protect alpha 1-antiprotease against inactivation by HOCl. However, rapid scavenging of HOCl might contribute to the anti-inflammatory effects of penicillamine, gold sodium thiomalate, phenylbutazone and primaquine.
authors.affiliation: Department of Biochemistry, King's College (KQC), London, U.K.
authors.forename: M
authors.initials: M
authors.lastname: Wasil
authors.forename: B
authors.initials: B
authors.lastname: Halliwell
authors.forename: C P
authors.initials: CP
authors.lastname: Moorhouse
authors.forename: D C
authors.initials: DC
authors.lastname: Hutchison
authors.forename: H
authors.initials: H
authors.lastname: Baum
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002712:Chlorides / Q000097:blood; D006997:Hypochlorous Acid / Q000097:blood*; D009504:Neutrophils / Q000201:enzymology; D009195:Peroxidase / Q000097:blood*; D000515:alpha 1-Antitrypsin / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D002712:Chlorides; D000515:alpha 1-Antitrypsin; D006997:Hypochlorous Acid; D009195:Peroxidase