Duplication of noncoding sequences in polyomavirus specifically augments the development of thymic tumors in mice.
A 40-base-pair duplication of noncoding sequences in polyomavirus specifically augmented the development of thymic epitheliomas following inoculation of virus into newborn mice. Virus strains carrying only one copy of this sequence induced a full spectrum of tumors except for overt thymic tumors. This 40-base-pair repeat, on the early side of the replication origin, constituted a tissue-specific regulatory determinant for tumor induction.
Freund
R
R
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115.
Dawe
C J
CJ
Benjamin
T L
TL
D000818:Animals; D001483:Base Sequence; D002277:Carcinoma / Q000235:genetics* / Q000382:microbiology; D004279:DNA, Viral / Q000235:genetics; D005814:Genes, Viral; D051379:Mice; D008809:Mice, Inbred C3H; D008969:Molecular Sequence Data; D005810:Multigene Family; D011120:Polyomavirus / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D013953:Thymus Neoplasms / Q000235:genetics* / Q000382:microbiology
D004279:DNA, Viral