[Immunohistochemical study of malignant fibrous histiocytoma].
Malignant fibrous histiocytomas (MFH) and other soft-tissue tumors were examined immunochemically (by the peroxidase-antiperoxidase technique) for the presence and location of alpha 1-antitrypsin (alpha 1-AT) and alpha 1-antichymotrypsin (alpha 1-ACT). alpha 1-AT and alpha 1-ACT were found in substantial amounts in 19 and 20 of the 20 MFH tumors examined, respectively. In the other soft-tissue tumors, they occurred inconsistently and in less than 50% of cells, mostly those with signs of damage. It is concluded that assays for alpha 1-AT and alpha 1-ACT may aid in the diagnosis and characterization of malignant fibrous histiocytoma.
Pozharisskiĭ
K M
KM
Nikitin
A Iu
AIu
D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D000514:alpha 1-Antichymotrypsin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
D014408:Biomarkers, Tumor; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin
Immunogistokhimicheskoe izuchenie zlokachestvennoĭ fibroznoĭ gistiotsitomy.