title: Effects of exposure to single or multiple combinations of the predominant toxic gases and low oxygen atmospheres produced in fires.
abstract: The toxicity of single and multiple fire gases is studied to determine whether the toxic effects of the combustion products from materials can be explained by the toxicological interactions (as indicated by lethality) of the primary fire gases or if minor, more obscure gases need to be considered. LC50 values for Fischer-344 rats have been calculated for the individual gases, carbon monoxide (CO), hydrogen cyanide (HCN), or decreased oxygen (O2), for 30-min exposures plus relevant postexposure periods using the NBS Toxicity Test Method. Combination experiments with CO and HCN indicate that they act in an additive manner. Synergistic effects have been found when the animals are exposed to certain combinations of CO and carbon dioxide (CO2). Five percent CO2 raised the threshold for deaths due to hypoxia and decreased the LC50 of HCN. Decreasing the O2 concentration in the presence of various mixtures of the other major fire gases increased the toxicity even further. A comparison of the concentrations of the major combustion products generated from a number of polymeric materials at their LC50 (30-min exposure plus 14-day postexposure) values with the combined pure gas results indicates that, in most cases, the observed toxicity may be explained by the toxicological interactions of the examined primary toxic fire gases. These results provide necessary information for the computer model currently being developed at the Center for Fire Research to predict the toxic hazard that people will experience under various fire scenarios.
authors.affiliation: Center for Fire Research, National Bureau of Standards, Gaithersburg, Maryland 20899.
authors.forename: B C
authors.initials: BC
authors.lastname: Levin
authors.forename: M
authors.initials: M
authors.lastname: Paabo
authors.forename: J L
authors.initials: JL
authors.lastname: Gurman
authors.forename: S E
authors.initials: SE
authors.lastname: Harris
mesh_terms: D000388:Air / Q000032:analysis*; D000818:Animals; D002245:Carbon Dioxide / Q000032:analysis / Q000633:toxicity; D002248:Carbon Monoxide / Q000032:analysis / Q000633:toxicity; D002263:Carboxyhemoglobin / Q000378:metabolism; D005390:Fires; D005740:Gases / Q000032:analysis / Q000097:blood / Q000633:toxicity*; D006856:Hydrogen Cyanide / Q000633:toxicity; D007700:Kinetics; D008297:Male; D009584:Nitrogen / Q000032:analysis; D010100:Oxygen / Q000032:analysis*; D011190:Potassium Cyanide / Q000032:analysis / Q000633:toxicity; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D005740:Gases; D002245:Carbon Dioxide; D006856:Hydrogen Cyanide; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; D011190:Potassium Cyanide; D009584:Nitrogen; D010100:Oxygen