Cutaneous herpes simplex virus lesions induced by ultraviolet radiation. A review of model systems and prophylactic therapy with oral acyclovir.
Animal and human models of ultraviolet radiation-induced herpes simplex virus disease provide opportunities to study the mechanism of virus latency and reactivation. These models can also be used to study the efficacy of antiviral agents. Prophylactic oral acyclovir altered the development of ultraviolet radiation-induced herpes labialis under both natural and experimental conditions.
Spruance
S L
SL
Department of Medicine, University of Utah School, Salt Lake City, Utah 84132.
D000212:Acyclovir / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D006561:Herpes Simplex / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D018139:Simplexvirus / Q000254:growth & development; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014775:Virus Activation / Q000528:radiation effects
D000212:Acyclovir