Studies of depressed interleukin-2 production by spleen cells from mice following infection with cytomegalovirus.
Spleen cells from mice infected with virulent and avirulent strains of murine cytomegalovirus showed depressed interleukin-2 production after ConA stimulation. Cell-mixing experiments indicated that this was due to a primary defect in non adherent cells. Spleen cells infected in vitro were also studied.
Blackett
S
S
Department of Microbiology, United Medical and Dental School, Guy's Hospital, London, U.K.
Mims
C A
CA
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D003586:Cytomegalovirus Infections / Q000276:immunology*; D007108:Immune Tolerance; D007376:Interleukin-2 / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D051379:Mice; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D007376:Interleukin-2; D003208:Concanavalin A