Hepatic phosphatidylcholine synthesis in deficiency of lysine and threonine: effect of malathion.
Rats fed on a rice diet deficient in lysine and threonine showed increased activities of CDP-Choline pathway enzymes and incorporation of (methyl-3H)-choline into hepatic microsomal phosphatidylcholine, compared to rats fed on the same diet supplemented with lysine and threonine. However, the amount of microsomal phosphatidylcholine was significantly decreased in rats fed a deficient rice diet. These results suggest an enhanced phosphatidylcholine catabolism in rats fed on a rice diet deficient in lysine and threonine. Malathion administration reduced the amount of phosphatidylcholine in all the groups.
Singh
Y
Y
Department of Biochemistry, V.P. Chest Institute, University of Delhi, India.
Chaudhary
V K
VK
Tyagi
S R
SR
Bhatnagar
R
R
Misra
U K
UK
D000818:Animals; D002797:Choline Kinase / Q000378:metabolism; D019916:Choline-Phosphate Cytidylyltransferase; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008239:Lysine / Q000172:deficiency*; D008294:Malathion / Q000494:pharmacology*; D008297:Male; D009713:Nucleotidyltransferases / Q000378:metabolism; D010713:Phosphatidylcholines / Q000096:biosynthesis*; D051381:Rats; D013912:Threonine / Q000172:deficiency*
D010713:Phosphatidylcholines; D013912:Threonine; D002797:Choline Kinase; D009713:Nucleotidyltransferases; D019916:Choline-Phosphate Cytidylyltransferase; D008239:Lysine; D008294:Malathion