5-substituted 2'-fluoro-arabinonucleosides as potential antiviral agents.
In order to study the electronic effects of 5-substituents of 2'-fluoro-ara-U on antiviral activity, eight nucleosides were synthesized and screened for their activity. Preliminary in vitro studies revealed that 5-thiocyano-, 5-hydroxy- and 5-formyl-ara-U are moderately active against HSV-1, HSV-2 and VZV, but they are also cytotoxic. None of these showed significant activity against CMV.
Huang
J T
JT
Sloan-Kettering Institute for Cancer Research, Graduate School of Medical Sciences, Cornell University, New York, NY 10021.
Schinazi
R F
RF
Gadler
H
H
Price
R W
RW
Su
T L
TL
Watanabe
K A
KA
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis*; D001086:Arabinofuranosyluracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D006801:Humans; D018139:Simplexvirus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014529:Uridine / Q000031:analogs & derivatives*; D014709:Vero Cells; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D001086:Arabinofuranosyluracil; D014529:Uridine