title: Plasma atrial natriuretic peptide and cyclic nucleotide levels before and after a marathon.
abstract: Plasma alpha-atrial natriuretic peptide (alpha-ANP) concentration and levels of cyclic nucleotides [guanosine 3',5'-cyclic monophosphate (cGMP) and adenosine 3',5'-cyclic monophosphate (cAMP)] were studied in 23 runners before and after a marathon race. Blood samples were drawn from an antecubital vein the morning before the race (base line), at 3 P.M. (i.e., 2 h before the start), on arrival, and 12 and 36 h and 7 days later. Compared with the base-line values of plasma alpha-ANP (5 pmol/l), cGMP (3.8 nmol/l), and cAMP (15.8 nmol/l), the plasma levels of alpha-ANP, cGMP, and cAMP were increased immediately after the marathon, respectively, to 12.0 pmol/l, 12.7 nmol/l, and 50.5 nmol/l. The increase in the plasma alpha-ANP concentration was related (r = 0.85; P less than 0.001) to the changes in plasma cGMP, plasma lactate, hematocrit, and body weight. The plasma cGMP and cAMP concentrations had returned to the prerace levels 12 h after the marathon, whereas the plasma alpha-ANP concentration was significantly lower (3.1 pmol/l) than the base-line values and increased above the prerace values 36 h (7.5 pmol/l) and 7 days (6.8 pmol/l) after the marathon. The plasma cGMP level was also higher 36 h (5.4 nmol/l) and 7 days (5.0 nmol/l) after the marathon race.
authors.affiliation: Department of Pathophysiology, Faculty of Medicine, University of Leuven, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Lijnen
authors.forename: P
authors.initials: P
authors.lastname: Hespel
authors.forename: J R
authors.initials: JR
authors.lastname: M'Buyamba-Kabangu
authors.forename: M
authors.initials: M
authors.lastname: Goris
authors.forename: R
authors.initials: R
authors.lastname: Lysens
authors.forename: E
authors.initials: E
authors.lastname: Vanden Eynde
authors.forename: R
authors.initials: R
authors.lastname: Fagard
authors.forename: A
authors.initials: A
authors.lastname: Amery
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure; D001835:Body Weight; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D004906:Erythrocyte Count; D006339:Heart Rate; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007773:Lactates / Q000097:blood; D008297:Male; D005082:Physical Exertion; D012420:Running
chemical_list: D006454:Hemoglobins; D007773:Lactates; D009320:Atrial Natriuretic Factor; D000242:Cyclic AMP; D006152:Cyclic GMP