title: Interference of oral poliovirus vaccine on RIT 4237 oral rotavirus vaccine.
abstract: A vaccination trial, performed on 86 3-month-old infants, has shown that the ability of the RIT 4237 live attenuated rotavirus strain to induce seroconversion is dramatically reduced when administered with live poliovirus vaccine. In a subsequent trial performed on 93 infants the attempt to overcome the poliovirus interference by administering two doses of associated vaccines was unsuccessful. No interference by the RIT 4237 strain on live attenuated polioviruses was observed.
authors.affiliation: Institute of Hygiene and Preventive Medicine, University of Catania, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Giammanco
authors.forename: V
authors.initials: V
authors.lastname: De Grandi
authors.forename: L
authors.initials: L
authors.lastname: Lupo
authors.forename: A
authors.initials: A
authors.lastname: Mistretta
authors.forename: S
authors.initials: S
authors.lastname: Pignato
authors.forename: D
authors.initials: D
authors.lastname: Teuween
authors.forename: H
authors.initials: H
authors.lastname: Bogaerts
authors.forename: F E
authors.initials: FE
authors.lastname: Andre
mesh_terms: D000284:Administration, Oral; D000914:Antibodies, Viral / Q000032:analysis; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage*; D011897:Random Allocation; D012401:Rotavirus / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D011054:Poliovirus Vaccine, Inactivated; D014765:Viral Vaccines