title: Renal hypercalciuria and metabolic acidosis associated with medullary sponge kidney: effect of alkali therapy.
abstract: Sixteen patients with medullary sponge kidney (MSK) and renal stones underwent evaluation of calcium metabolism and acid base balance. Six normal subjects and eight patients with non-MSK absorptive hypercalciuria served as control. Nine (56%) were hypercalciuric and seven (44%) were normocalciuric (N-MSK). Hypercalciuria was divided into absorptive (AH-MSK, n = 2) and renal leak hyerpcalciuria (RH-MSK, n = 7). The mean of minimal urine pH of RH-MSK group (5.28 +/- 0.09 (SE] was significantly higher than that of normal control (4.78 +/- 0.12) and of non-MSK AH (4.80 +/- 0.6) during acute acid challenge. The mean of the arterial blood HCO3 concentration of RH-MSK group was significantly lower than that of two control groups. The urine calcium and a frequency of stone passage were decreased significantly after alkali treatment in RH-MSK.
authors.affiliation: Department of Urology, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Higashihara
authors.forename: K
authors.initials: K
authors.lastname: Nutahara
authors.forename: T
authors.initials: T
authors.lastname: Niijima
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000150:complications* / Q000188:drug therapy; D000328:Adult; D001639:Bicarbonates / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood / Q000652:urine*; D000242:Cyclic AMP / Q000652:urine; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000150:complications* / Q000188:drug therapy; D008297:Male; D007691:Medullary Sponge Kidney / Q000150:complications*; D010710:Phosphates / Q000097:blood; D012964:Sodium / Q000627:therapeutic use*; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D010710:Phosphates; D017693:Sodium Bicarbonate; D012964:Sodium; D000242:Cyclic AMP; D002118:Calcium