Differential effects of chronic ethanol on apomorphine-induced locomotion, climbing and aggression in rats.
Male Wistar rats were tested for apomorphine-induced locomotion, climbing and aggression after 3 week's intragastric ethanol (EtOH) treatment, 5 g/kg as 20% solution daily. The ability of apomorphine (APO) to elicit rearing (1 mg/kg i.p.) and climbing (0.5 mg/kg i.p.) was significantly suppressed in EtOH withdrawn animals. General locomotor activity in response to 1 mg/kg of APO i.p. did not differ between control and EtOH-treated groups. Affective aggression was checked in pairs of low-aggressive rats, i.e. resistant to the aggression inducing action of 10 mg/kg APO. No symptoms of aggression appeared in control animals whereas EtOH administered rats responded with marked aggression to APO. The different effect of chronic EtOH on responsiveness to APO in three behavioral models is discussed in terms of varying involvement of dopaminergic systems and receptors in behavioral phenomena as well as their susceptibility to prolonged EtOH.
Puciłowski
O
O
Department of Pharmacology & Physiology of the Nervous System, Institute of Psychiatry & Neurology, Warsaw, Poland.
Trzaskowska
E
E
Kostowski
W
W
D000374:Aggression / Q000187:drug effects*; D000428:Alcohol Drinking / Q000502:physiology; D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D004298:Dopamine / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D011954:Receptors, Dopamine; D001058:Apomorphine; D004298:Dopamine