title: Restricted heterogeneity of antibody to gp120 and p24 in AIDS.
abstract: Neurologic complications and cerebrospinal fluid (CSF) abnormalities are common in AIDS. We found that a substantial number of AIDS patients with neurologic involvement had oligoclonal IgG bands in CSF and sera by IEF. Using an IEF-Ag overlay technique, anti-gp120 antibody activity was demonstrated more frequently than anti-p24 antibody activity. These antibody activities exhibited restricted heterogeneity of their IEF pattern; this restriction may contribute to the relatively low titers of neutralizing antibody found in AIDS sera. None of the CSF and serum oligoclonal bands showed anti-HIV antibody activity, suggesting that they are directed against opportunistic agents or result from immunodysregulation.
authors.affiliation: Abbott Laboratories, North Chicago, IL 60064.
authors.forename: L M
authors.initials: LM
authors.lastname: Grimaldi
authors.forename: R P
authors.initials: RP
authors.lastname: Roos
authors.forename: S G
authors.initials: SG
authors.lastname: Devare
authors.forename: W G
authors.initials: WG
authors.lastname: Robey
authors.forename: J M
authors.initials: JM
authors.lastname: Casey
authors.forename: M E
authors.initials: ME
authors.lastname: Gurney
authors.forename: B R
authors.initials: BR
authors.lastname: Apatoff
authors.forename: D
authors.initials: D
authors.lastname: Lazzarin
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D000914:Antibodies, Viral / Q000302:isolation & purification* / Q000502:physiology; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D003704:Dementia / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies; D016655:HIV Core Protein p24; D015699:HIV Envelope Protein gp120; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D012191:Retroviridae Proteins / Q000276:immunology*; D012709:Serum Albumin / Q000134:cerebrospinal fluid
chemical_list: D000914:Antibodies, Viral; D015483:HIV Antibodies; D016655:HIV Core Protein p24; D015699:HIV Envelope Protein gp120; D007074:Immunoglobulin G; D012191:Retroviridae Proteins; D012709:Serum Albumin