[Immunotherapy with taktivin and myelolipid in experimental influenzal infection].
In experiments on mice the influence of thymic and medullary immunomodulators on the character of fatal influenza infection, the reproduction of influenza virus in pulmonary and thymic tissues and the level of MIF production was studied. Tactivin and myelolipid, used both separately and in combination, proved to be immunotherapeutic preparations capable of decreasing mortality rate by 70-95%. The immunological effects of these preparations were manifested by an increase in the functional activity of the T-link of immunity in the absence of the stimulation of antibody formation.
Aleksandrova
N N
NN
Arion
V Ia
VIa
Slobodeniuk
A V
AV
Sanina
I V
IV
D028341:Activins; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001853:Bone Marrow / Q000276:immunology*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D009980:Influenza A virus / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009842:Oligopeptides; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000276:immunology; D010455:Peptides; D013949:Thymus Extracts; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D009842:Oligopeptides; D010455:Peptides; D013949:Thymus Extracts; C044147:activin B; D028341:Activins; C048617:myelopeptides; C036191:T-activin
Immunoterapiia taktivinom i mielopidom éksperimental'noĭ grippoznoĭ infektsii.