The vasopressin content in the neurohypophysis under conditions of intracerebroventricular beta-adrenergic blockade in euhydrated and dehydrated rats.
Rats dehydrated for up to 8 days were given propranolol hydrochloride into the left brain ventricle in a daily dose of 10 micrograms. In euhydrated rats the single dose of propranolol diminished significantly the vasopressin content in neurohypophysis. In animals dehydrated for two days, the depletion of the neurohypophysial vasopressin storage was less marked under conditions of treatment with propranolol. At the fourth and eighth day of deprivation of water, propranolol did not modify the decrease of neurohypophysial vasopressin due to stimulation of osmodetectors.
Janus
J
J
Department of Pathophysiology, University School of Medicine, Lódz.
Guzek
J W
JW
D000818:Animals; D003681:Dehydration / Q000378:metabolism; D007276:Injections, Intraventricular; D008297:Male; D010904:Pituitary Gland, Posterior / Q000378:metabolism*; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism; D014667:Vasopressins / Q000378:metabolism*
D011943:Receptors, Adrenergic, beta; D014667:Vasopressins; D011433:Propranolol