Inhibition of dietary fat-promoted colon carcinogenesis in rats by supplemental calcium or vitamin D3.
A 2 X 2 X 2 factorial experimental design was used to investigate the effects of supplemental calcium (Ca) (0.5% versus 1.0% of diet as Ca gluconate) and vitamin D3 (D) (1000 IU/kg diet versus 2000 IU/kg diet) on 1,2-dimethylhydrazine-induced colon carcinogenesis in male F344 rats promoted with a 20% corn oil diet. Animals on the high-fat (HF) diet had an increased tumor incidence compared to the low-fat (LF) control diet (86% versus 53%, P less than 0.05) and supplemental Ca or D reduced this to or below the LF incidence (HF + Ca: 53%, HF + D: 47%). However, supplemental Ca or D had no inhibitory effect with LF diets (LF + Ca: 67%, LF + D: 60%). The results of this study indicate a possible role for supplemental Ca or D in the prevention of colon cancer, effective only in HF diets.
Pence
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BC
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock 79430.
Buddingh
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F
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002762:Cholecalciferol / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000209:etiology*; D004041:Dietary Fats / Q000009:adverse effects*; D004347:Drug Interactions; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D004041:Dietary Fats; D002762:Cholecalciferol; D002118:Calcium