Ependymal differentiation of a glioblastoma multiforme after heterotransplantation into nude mice.
A glioblastoma multiforme from a 64-year-old man was heterotransplanted sc into nude mice (nu/nu BALB/c out-bred). The subsequent growth of the transplanted tumor featured the appearance and eventual domination by cells with ependymal characteristics. This finding supports the view that the host's influence on heterotransplants may be substantial and should be considered when extrapolating the results of therapeutic trials on such animal models to the clinical situation. The view that ependymal cells and astrocytes share a common precursor is also partly supported by the observations.
Jacobsen
P F
PF
Department of Neuropathology, Royal Perth Hospital, Western Australia.
Parker
T J
TJ
Papadimitriou
J M
JM
D000818:Animals; D002454:Cell Differentiation; D004805:Ependyma / Q000473:pathology*; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous