Considerations on the nature of mu, kappa, and sigma receptors.
It is assumed that opioid receptors are flexible, distorted by agonists but not by antagonists. Combined with Martin's model of the receptors, this assumption permits reasonable interpretation of experimental facts.
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Department of Pharmacology, Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19102.
D001665:Binding Sites; D004723:Endorphins / Q000378:metabolism; D008959:Models, Neurological; D011957:Receptors, Opioid / Q000378:metabolism*; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D017480:Receptors, sigma
D004723:Endorphins; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D017480:Receptors, sigma