[Clinical and endocrinologic studies of the treatment of ovarian insufficiency manifestations following hysterectomy with intact adnexa].
60 hysterectomized patients under 40 years old, who all had at least one intact ovary and still complained of climacteric symptoms, were treated with estriol, conjugated estrogens, estrogen-gestagen sequential therapy or an extract from cimicifuga racemosa after randomized distribution into 4 equal groups. Therapy was controlled after 4, 8, 12 and 24 weeks with a modified Kupperman-Index that also included trophic disorders of the genitals, and also by serum-FSH and -LH measurement. In all groups, the modified Kupperman-Index became significantly lower, the parallel decrease of gonadotropins could not be confirmed statistically, however. There were no significant differences between groups concerning therapy success.
Lehmann-Willenbrock
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E
Abteilung Frauenheilkunde im Zentrum, Christian Albrechts-Universität und Michaelis-Hebammenschule, Kiel.
Riedel
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HH
D000328:Adult; D002979:Climacteric / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004338:Drug Combinations / Q000627:therapeutic use; D004958:Estradiol / Q000627:therapeutic use; D004964:Estriol / Q000627:therapeutic use; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008594:Menopause, Premature / Q000187:drug effects; D009640:Norethindrone / Q000031:analogs & derivatives / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use; D011897:Random Allocation
D004338:Drug Combinations; D004966:Estrogens, Conjugated (USP); D010936:Plant Extracts; D004958:Estradiol; C032040:Trisequens; D004964:Estriol; D009640:Norethindrone
Klinische und endokrinologische Untersuchungen zur Therapie ovarieller Ausfallserscheinungen nach Hysterektomie unter Belassung der Adnexe.