[Value of calcitonin and 6-oxo-prostaglandin Fl alpha in the differentiation of lung cancers].
Plasma calcitonin and 6-oxo-Prostaglandin-F1 alpha (6-oxo-PGF1 alpha), one of the stable metabolite of prostacyclin, were determined in patients with malignant and non-malignant diseases of the lung. 11 out of 14 patients with small cell carcinoma and only 3 out of 17 patients with other histological types of lung cancer had abnormally elevated plasma calcitonin levels. 6-oxo-PGF1 alpha levels were significantly higher in patients with different types of lung cancer, compared to a control group with non-malignant lung disease. Combining the results of calcitonin and 6-oxo-PGF1 alpha measurements led to improved specificity and efficiency for the correct differentiation between small cell and non-small cell carcinoma of the lung; the predictive value for the diagnosis of small cell carcinoma approached 90%.
Burghuber
O C
OC
Kovarik
J
J
Woloszczuk
W
W
Sehnal
E
E
Sinzinger
H
H
Weissel
M
M
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D002116:Calcitonin / Q000097:blood*; D018288:Carcinoma, Small Cell / Q000097:blood* / Q000175:diagnosis; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis; D008297:Male
D015121:6-Ketoprostaglandin F1 alpha; D002116:Calcitonin
Die Wertigkeit von Kalzitonin und 6-oxo-Prostaglandin-F1 alpha in der Differenzierung von Lungenkarzinomen.