Treatment of mice bearing a Krebs ascitic tumor by means of a protocol based on radioactive copper (64Cu). II. Analysis of the treatment.
A new treatment is proposed for mice bearing a Krebs ascitic tumor targeting on both the malignant cells and the host cells having the "cancer functioning" (cancer cells) (Anticancer Res 9: 941-946 1989). It is shown that the treatment (a) injure specifically via 64Cu transmutation the DNA of the malignant cells and further perform (with thioproline or spermine) a "reverse transformation" on the damage DNA; (b) restore a "noncancer functioning" in the host cells which had become "cancer cells"; this restoration was performed using, at physiological concentrations, natural compounds already present in all cell types such as metal ions, amino acids, vitamin D2, thyroxine and chelating substances. To decrease the damage induced in the organism by the radiation emitted by 64Cu, a radioprotector, glycerol, was used. Two different strains of mice were used (Swiss or CBA). For each of them, the same treatment was efficient on condition that thioproline or spermine was used for Swiss or CBA mice respectively.
Guillé
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Université Paris-Sud, Biologie Moléculaire Végétale UA 1128, Orsay, France.
Apelgot
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D000818:Animals; D002287:Carcinoma, Krebs 2 / Q000503:physiopathology / Q000532:radiotherapy*; D003301:Copper Radioisotopes / Q000627:therapeutic use*; D004249:DNA Damage; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D008962:Models, Theoretical; D011878:Radiotherapy / Q000379:methods; D013096:Spermine / Q000627:therapeutic use; D013997:Time Factors
D003301:Copper Radioisotopes; D013096:Spermine