title: Expression of MHC class I genes in mouse hepatitis virus (MHV-A59) infection and in multiple sclerosis.
abstract: Our studies revealed that virus induced demyelination as well as human inflammatory demyelination involves upregulation of class I MHC genes and surface expression of antigens encoded by these genes. Induction involves the action of an intermediate soluble factor/s which is at present unknown. These findings suggest that MHC class I restricted, cytotoxic T lymphocyte (CTL) reactions, against self or foreign antigens may play a role in these conditions. These findings may help to elucidate the mechanism of coronavirus-induced demyelination as well as the pathogenesis of multiple sclerosis.
authors.affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: E
authors.initials: E
authors.lastname: Lavi
authors.forename: A
authors.initials: A
authors.lastname: Suzumura
authors.forename: L A
authors.initials: LA
authors.lastname: Lampson
authors.forename: R M
authors.initials: RM
authors.lastname: Siegel
authors.forename: D M
authors.initials: DM
authors.lastname: Murasko
authors.forename: D H
authors.initials: DH
authors.lastname: Silberberg
authors.forename: S R
authors.initials: SR
authors.lastname: Weiss
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003711:Demyelinating Diseases / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation; D006524:Hepatitis, Viral, Animal / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007125:Immunogenetics; D008285:Major Histocompatibility Complex; D051379:Mice; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology; D006517:Murine hepatitis virus; D009457:Neuroglia / Q000276:immunology