Effects of bicuculline-induced seizures on benzodiazepine and adenosine receptors in developing rat brain.
The effects of seizures induced by an acute administration of bicuculline have been investigated on the central benzodiazepine and adenosine receptors in developing rats and in adults. Generalized seizures rapidly increased the total number of both benzodiazepine binding sites and adenosine A1 receptors, without changes in receptor affinity (KD). It was concluded that such a phenomenon may facilitate the anticonvulsant action of benzodiazepine and adenosine via receptor binding and that it could be an adaptative process to protect subjects against recurrent seizures, especially in newborns.
Daval
J L
JL
INSERM U. 272, Pathologie et Biologie du Developpement Humain, Nancy, France.
Sarfati
A
A
D000818:Animals; D001640:Bicuculline; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D003975:Diazepam / Q000378:metabolism; D005260:Female; D008297:Male; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D011983:Receptors, Purinergic / Q000378:metabolism*; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
D011963:Receptors, GABA-A; D011983:Receptors, Purinergic; D003975:Diazepam; D001640:Bicuculline