title: Insulin sensitivity in third trimester pregnancy. A randomized study of dietary effects.
abstract: The metabolic effects of three diets were investigated in a randomized study in 15 non-pregnant women and 14 pregnant women in the third trimester; all the women were of normal weight. After 2-week periods of habituation to each diet, metabolic profiles were performed on standardized intakes. Diet 1 contained 40% of energy as carbohydrate and 10 g dietary fibre representing typical Western intakes. Diet 2 contained 40% energy as carbohydrate and 52 g dietary fibre and diet 3 contained 60% of energy as carbohydrate and 84 g dietary fibre, representing typical developing world intakes. No deterioration in glucose homeostasis in pregnancy was seen on any of the three diets in contrast to previous work. On diet 1 there was a loss of insulin sensitivity in pregnancy, but not on diets 2 and 3. The loss of insulin sensitivity which is typical of Western women in the third trimester of pregnancy and is considered to be physiological, may be a diet-induced artefact.
authors.affiliation: University Department of Obstetrics and Gynaecology, Northern General Hospital, Sheffield.
authors.forename: R B
authors.initials: RB
authors.lastname: Fraser
authors.forename: F A
authors.initials: FA
authors.lastname: Ford
authors.forename: G F
authors.initials: GF
authors.lastname: Lawrence
mesh_terms: D020155:3-Hydroxybutyric Acid; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D004043:Dietary Fiber / Q000008:administration & dosage*; D005260:Female; D005990:Glycerol / Q000097:blood; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance; D007773:Lactates / Q000097:blood; D011247:Pregnancy / Q000378:metabolism*; D011263:Pregnancy Trimester, Third; D011897:Random Allocation
chemical_list: D001786:Blood Glucose; D004043:Dietary Fiber; D006885:Hydroxybutyrates; D007328:Insulin; D007773:Lactates; D005990:Glycerol; D020155:3-Hydroxybutyric Acid