Infection by multiple viruses and lymphocyte abnormalities at the diagnosis of diabetes.
Evidence for an ongoing adenovirus infection and preceding EB and Coxsackie B virus infections was found in a 2-year-old boy at the diagnosis of insulin-dependent diabetes. An inverted T-helper/T-suppressor lymphocyte ratio and activation of T cells with a suppressor-cytotoxic phenotype were detected. A combination of multiple viral infections may be responsible for the rapid destruction of pancreatic beta cells in this case.
Surcel
H M
HM
National Public Health Institute, Department of Paediatrics, University of Oulu, Finland.
Ilonen
J
J
Käär
M L
ML
Hyöty
H
H
Leinikki
P
P
D000257:Adenoviridae Infections / Q000150:complications / Q000276:immunology; D002675:Child, Preschool; D003384:Coxsackievirus Infections / Q000150:complications / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D029822:Enterovirus B, Human / Q000276:immunology; D006684:HLA-DR Antigens; D006566:Herpesviridae Infections / Q000150:complications / Q000276:immunology; D006801:Humans; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*; D014777:Virus Diseases / Q000150:complications* / Q000276:immunology
D006684:HLA-DR Antigens