title: [A case report: primary hyperparathyroidism--comparison before and after parathyroidectomy by oral calcium tolerance test].
abstract: To evaluate the cause of hypercalciuria, we carried out the oral calcium tolerance test before and after parathyroidectomy in a patient with primary hyperparathyroidism who had recurrent and multiple nephrolithiasis. Preoperative laboratory examination showed hypercalcemia, hypophosphetamia, hypercalciuria, decrease in % tubular reabsorption of phosphorus and strikingly elevated urinary cyclic AMP excretion. The oral calcium tolerance test indicated a significantly greater increase in serum calcium (delta serum calcium: 1.4 mg/dl vs 0.8 mg/dl) and a significantly greater suppression of urinary cyclic AMP excretion (delta U-cyclic AMP:-3.56 moles/gCre vs-1.17 moles/gCre) before parathyroidectomy than after. These results showed that hypercalciuria in this case was induced not only by the significant increase in the filtrated load of calcium but by the reduction in the resorption of calcium in the distal tubule caused by the significantly suppressed parathyroid hormone effect.
authors.affiliation: Department of Urology, Toyonaka City Hospital.
authors.forename: W
authors.initials: W
authors.lastname: Sakamoto
authors.forename: H
authors.initials: H
authors.lastname: Kawashima
authors.forename: T
authors.initials: T
authors.lastname: Nishijima
authors.forename: M
authors.initials: M
authors.lastname: Senju
authors.forename: T
authors.initials: T
authors.lastname: Kishimoto
authors.forename: M
authors.initials: M
authors.lastname: Maekawa
mesh_terms: D000284:Administration, Oral; D002118:Calcium / Q000378:metabolism / Q000652:urine*; D000242:Cyclic AMP / Q000652:urine; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000601:surgery / Q000652:urine*; D007686:Kidney Tubules, Distal / Q000378:metabolism; D008875:Middle Aged; D010280:Parathyroid Glands / Q000601:surgery*; D010281:Parathyroid Hormone / Q000502:physiology
chemical_list: D010281:Parathyroid Hormone; D000242:Cyclic AMP; D002118:Calcium