Cell-mediated immunity to varicella-zoster virus infection in strain 2 guinea pigs.
Young adult male strain 2 guinea pigs were inoculated intramuscularly with varicella-zoster virus (VZV) cultured in fetal guinea pig tissue cultures. Lymphocyte proliferation and interleukin 2 secretion in response to viral antigen challenge in vitro were measured at weekly intervals for 2 months and periodically thereafter. VZV-specific immunity was apparent 2 weeks after infection, peaking after 2 weeks (lymphoproliferation) or 1-2 months (interleukin 2 secretion). Diminished but significant anamnestic responses were detected as late as 30 months after infection.
Jenski
L
L
Division of Hematology, Children's Hospital Research Foundation, Cincinnati, Ohio 45229-2899.
Myers
M G
MG
D000818:Animals; D002644:Chickenpox / Q000276:immunology*; D006168:Guinea Pigs; D006562:Herpes Zoster / Q000276:immunology*; D014645:Herpesvirus 3, Human / Q000276:immunology; D007111:Immunity, Cellular; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008297:Male
D007376:Interleukin-2