title: Two classes of PDGF receptor recognize different isoforms of PDGF.
abstract: Previous studies involving platelet-derived growth factor (PDGF) have been based on the premise that a single cell-surface receptor binds all three isoforms of PDGF (AA, BB, and AB). It is now shown that two populations of PDGF receptor exist and can be distinguished by their ligand binding specificity. The B receptor binds only the BB dimer, whereas the A/B receptor binds AA, BB, and AB dimers. Human dermal fibroblasts appear to express seven times as much B receptor as A/B receptor. The B receptor is responsible for most PDGF receptor phosphorylation.
authors.affiliation: Department of Pathology, University of Washington, Seattle 98195.
authors.forename: C E
authors.initials: CE
authors.lastname: Hart
authors.forename: J W
authors.initials: JW
authors.lastname: Forstrom
authors.forename: J D
authors.initials: JD
authors.lastname: Kelly
authors.forename: R A
authors.initials: RA
authors.lastname: Seifert
authors.forename: R A
authors.initials: RA
authors.lastname: Smith
authors.forename: R
authors.initials: R
authors.lastname: Ross
authors.forename: M J
authors.initials: MJ
authors.lastname: Murray
authors.forename: D F
authors.initials: DF
authors.lastname: Bowen-Pope
mesh_terms: D001667:Binding, Competitive; D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017479:Receptors, Platelet-Derived Growth Factor; D012867:Skin / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D010982:Platelet-Derived Growth Factor; D011956:Receptors, Cell Surface; D017479:Receptors, Platelet-Derived Growth Factor