title: [Two cases of the middle fossa tumor following radiotherapy against retinoblastoma].
abstract: Two cases of brain tumors which developed after radiotherapy against retinoblastomas are reported. A 17-year-old girl was admitted with a chief complaint of swelling in her forehead after head injury in July, 1981. At 7 months old her left eye had been enucleated and she had received radiation therapy of 40 Gy to the right eye because of her bilateral retinoblastoma. On admission a CT scan revealed a high density mass with a partial low density area in her right middle fossa. A right frontotemporal craniotomy was performed and the tumor was removed subtotally, which was diagnosed as a malignant fibrous histiocytoma. The second case was a 14-year-old boy, who had received radiotherapy of 39.6 Gy against retinoblastoma of the right eye after enucleation at 2 months old. He had been well for 14 years after the therapy and was admitted to the hospital with complaints of headache, nausea, vomiting and unsteady gait in January 1985. A CT scan demonstrated a large contrast enhancing mass in the righ middle fossa, which was removed subtotally on January 14, 1985. A histological diagnosis of fibroblastic meningioma was made. Each patient developed a secondary brain tumor after radiotherapy against retinoblastoma. Those tumors appear to be radiation induced, although 10 to 15% of the patients who survived retinoblastoma without radiotherapy had been reported to develop secondary nonocular tumors. The patients with retinoblastoma should be followed up carefully after the initial treatment.
authors.affiliation: Department of Neurosurgery, National Cancer Center, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shibui
authors.forename: K
authors.initials: K
authors.lastname: Nomura
authors.forename: K
authors.initials: K
authors.lastname: Matsuoka
authors.forename: A
authors.initials: A
authors.lastname: Kaneko
authors.forename: T
authors.initials: T
authors.lastname: Nakajima
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology; D005134:Eye Neoplasms / Q000532:radiotherapy*; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000209:etiology* / Q000473:pathology; D008579:Meningioma / Q000209:etiology* / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D011879:Radiotherapy Dosage; D012175:Retinoblastoma / Q000532:radiotherapy*