[Comparison of platelet activity, fibrinolysis and environmental factors in 50 Africans and 50 Europeans. Role of fish consumption].
The authors have studied 50 Ivorians and 50 Europeans people, all living in Abidjan for at least 10 years. Platelet aggregability with increasing ADP concentration (0.6, 1.2, 2.4 mumoles/l), collagen (0.4 mg/l), or ristocetin (1 g/l) was examined. Fibrinolysis and the euglobulin test were also studied before and after anoxia. Other blood parameters measured were: hematocrit, hemoglobin level, platelet count, bleeding time, Howell coagulation test, cephalin tests, prothrombin activity ratio, fibrinogen level. Metabolic tests included: glycemia, cholesterolemia, triglyceridemia, uricemia, A1 and B apoproteins, protidemia, gamma globulinemia. Environmental factors such as physical activity, alcohol and smoking habits, fish consumption, chloroquine prophylaxis were evaluated. The most evident result was lower platelet aggregability in Ivorian people as compared to Europeans. A more precocious and important fibrinolysis activity, either spontaneous or after anoxia was noted in the Ivorian group. Lower platelet number, fibrinogen level, and prothrombin activity were present in the Ivorian group as compared to the European people. The authors eliminated the influence of age, and considered environmental factors as predominant in the genesis of such difference, i.e., hypocholesterolemia, lower smoking and drinking levels. They emphasized the higher fish consumption in Ivorian people.
Bertrand
E
E
Institut de Cardiologie d'Abidjan, Côte-d'Ivoire.
Cloitre
B
B
Ticolat
R
R
Darracq
R
R
Rain
S F
SF
D000328:Adult; D000818:Animals; D044383:Black People; D007560:Cote d'Ivoire; D004032:Diet; D005260:Female; D005342:Fibrinolysis; D005396:Fish Products; D006801:Humans; D008297:Male; D010974:Platelet Aggregation; D044465:White People
Activité plaquettaire, fibrinolyse et facteurs d'environnement comparés chez 50 africains et 50 européens. Rôle de la consommation de poisson.