[Specific changes in the sodium chloride intake and activity of the taste receptor apparatus of rats administered the peptide litorin and its albumin conjugate].
The role of bombesin-like peptide litorin in control of salt consumption was studied in rats. The influence of exogenous injection and binding of the endogenous litorin in the organism on the consumption of sodium chloride and sucrose solutions was analyzed in deprived rats in the process of 15-min. testing. It was found that intraperitoneal injection of 10(-6) - 10(-5) M of litorin led to an increase, and rats immunization by peptide conjugate with ox serum albumin--to a decrease of the consumption of salt solution, without changing the consumption of sucrose solution. Titres of antibodies to litorin in the plasma of rats immunized with the conjugate were higher than in the control. Intraperitoneal, subcutaneous or intranasal injections of 10(-5) M of litorin led to selective increase of gustatory responses (recorded from the chorda tympani) to tongue stimulation by salt and acid solutions not influencing the responses to quinine and sucrose in anesthetized rats. The study shows, that the peptide litorin selectively participates in the control of sodium chloride consumption. In the process of such control the increase of taste apparatus sensitivity to the sodium chloride is probably involved.
Serova
O N
ON
Obukhova
M F
MF
Esakov
A I
AI
Ashmarin
I P
IP
Storozheva
Z I
ZI
D000818:Animals; D000906:Antibodies / Q000032:analysis; D004594:Electrophysiology; D007114:Immunization; D008297:Male; D009842:Oligopeptides / Q000276:immunology / Q000494:pharmacology*; D051381:Rats; D012710:Serum Albumin, Bovine / Q000276:immunology / Q000494:pharmacology*; D012965:Sodium Chloride / Q000378:metabolism*; D013649:Taste / Q000187:drug effects / Q000502:physiology; D013650:Taste Buds / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D000906:Antibodies; D009842:Oligopeptides; C061578:litorin-albumin conjugate; D012710:Serum Albumin, Bovine; D012965:Sodium Chloride; C010212:litorin
Spetsificheskoe izmenenie protsessa potrebleniia khlorida natriia i aktivnosti vkusovogo retseptornogo apparata u krys v usloviiakh vvedeniia peptida litorina i ego kon''iugata s al'buminom.