Avoidance responding in mice with diabetes mellitus.
In order to examine the behavioral concomitants of the neuroendocrine state of diabetes mellitus, the behavior of diabetic and normal male mice was compared in two behavioral paradigms. Diabetic mice were found to display significantly more passive avoidance to shock and significantly more submissive social behavior as compared to control mice. Furthermore, within the group of diabetic mice, mice showing the most passive avoidance also displayed the most submissive behavior. These findings suggest that diabetes mellitus may have effects on the neuroendocrine system that are manifested as changes in behavior.
Leedom
L J
LJ
Meehan
W P
WP
Zeidler
A
A
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000374:Aggression / Q000502:physiology; D000818:Animals; D001143:Arousal / Q000502:physiology; D001362:Avoidance Learning; D003345:Corticosterone / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000523:psychology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011930:Reaction Time / Q000502:physiology
D000324:Adrenocorticotropic Hormone; D003345:Corticosterone