Iodine supplementation: comparison of oral or intramuscular iodized oil with oral potassium iodide. A controlled trial in Zaire.
A community-based controlled trial of iodine supplementation comparing oral or intramuscular iodized oil with oral potassium iodide has been carried out in 23 severely iodine-deficient villages in Eastern Zaire. The overall goitre prevalence in the population (n = 5999) was 61% and mean urinary iodine excretion in sample of 57 women 10.9 (SD 6.8) micrograms/g creatinine. All adults in three groups of four villages were given single doses of potassium iodide of 0.5 g, 1.0 g, and 2.0 g respectively. A fourth group was given oral iodized oil (2 ml) and a fifth placebo-treated. A further three villages were given intramuscular iodized oil (2 ml). The effectiveness of supplementation was assessed by measurements of bloodspot thyroxine (T4) concentration in women of reproductive age in the villages. The effects of iodide were small and inconsistent. Eight months after supplementation with oral iodized oil the distribution of T4 concentrations was similar to that seen with intramuscular oil. We conclude that oral iodized oil is an effective alternative to injected oil and would be feasible for iodine supplementation in remote areas with untrained people.
Phillips
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MRC Environmental Epidemiology Unit, Southampton General Hospital, UK.
Lusty
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Osmond
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Church
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D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D015023:Democratic Republic of the Congo; D004311:Double-Blind Method; D005260:Female; D006042:Goiter / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular; D007455:Iodine / Q000008:administration & dosage / Q000172:deficiency / Q000627:therapeutic use*; D007459:Iodized Oil / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D011193:Potassium Iodide / Q000008:administration & dosage / Q000627:therapeutic use; D013974:Thyroxine / Q000097:blood
D011193:Potassium Iodide; D007459:Iodized Oil; D007455:Iodine; D013974:Thyroxine