[Morphological restructuring of the cellular elements of the ventral tegmental area in selective damage to the catecholaminergic systems of the brain].
Electron microscopical investigation of the ventral tegmental area at various time after administration of a specific neurotoxin 6-hydroxydopamine made it possible not only to reveal catecholamine reactive elements, but also those structural reorganizations in them, that are dependent on the lesion of the catecholaminergic systems, including certain changes in the receptor apparatus. Dark neurons with the change of different organelles preserve for a long time, up to 2.5 months. Reactive and destructive reorganizations of some axons, terminal buttons and postsynaptic poles of the ventral tegmental area are accompanied with certain functional disturbances, observed both experimentally and at a pathological process. The results of the work demonstrate that under conditions of the model experiments there is a possibility to study various stages of pathogenesis of a number of nervous-psychical diseases, connected or accompanied with disorders in certain mediator systems.
Kucherenko
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D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D006892:Hydroxydopamines / Q000633:toxicity; D008854:Microscopy, Electron; D009457:Neuroglia / Q000187:drug effects / Q000648:ultrastructure; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects*; D017983:Receptors, Catecholamine; D013681:Tegmentum Mesencephali / Q000187:drug effects / Q000648:ultrastructure*; D013997:Time Factors
D002395:Catecholamines; D006892:Hydroxydopamines; D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine; C027802:5-hydroxydopamine
Morfologicheskaia perestroĭka kletochnykh élementov ventral'noĭ tegmental'noĭ oblasti pri izbiratel'nom povrezhdenii katekholaminergicheskikh sistem mozga.