title: Failure of experimental vaccines to protect against infection with ovine progressive pneumonia (maedi-visna) virus.
abstract: Cell culture medium was harvested from cells infected with ovine progressive pneumonia (OPP) virus and used to prepare killed virus vaccines. Virus was inactivated by either heat, formalin, or ethyleneimine and used either without adjuvant, with Freund incomplete adjuvant, or with aluminum hydroxide adjuvant to vaccinate sheep. The sheep produced precipitating antibody against the virus but were not protected against infection when challenged with live OPP virus.
authors.affiliation: National Animal Disease Center, United States Department of Agriculture, Ames, IA 50010.
authors.forename: R C
authors.initials: RC
authors.lastname: Cutlip
authors.forename: H D
authors.initials: HD
authors.lastname: Lehmkuhl
authors.forename: K A
authors.initials: KA
authors.lastname: Brogden
authors.forename: M J
authors.initials: MJ
authors.lastname: Schmerr
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D003470:Culture Media; D005260:Female; D008297:Male; D011021:Pneumonia, Progressive Interstitial, of Sheep / Q000276:immunology* / Q000517:prevention & control; D012756:Sheep; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*; D014790:Visna-maedi virus / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D003470:Culture Media; D014613:Vaccines, Attenuated; D014765:Viral Vaccines