[Multifactor analysis of parameters of immunity under the combined action of doxycycline and a low molecular weight immunomodulator of microbial origin].
The effect of doxycycline combination with a low molecular immunomodulator of microbial origin on the primary immune response to the vaccine EV antigens was studied in multifactor experiments. Mathematical processing of the data provided construction of polynomial statistic models of the second order describing increased delayed type hypersensitivity (IDTH) and the antibody titer. Analysis of the quasimonofactor models revealed different character of regulation of the cellular and humoral response. Nomograms were plotted for precise quantitative estimation of the dose-time parameters of the regimens for combined use of the antibiotic and immunomodulator providing the required levels of IDTH and the antibody titer.
Nikitin
A V
AV
Fomina
I P
IP
Ivanitskaia
L P
LP
Fishman
V M
VM
Bodunkova
L E
LE
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000941:Antigens / Q000276:immunology; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005163:Factor Analysis, Statistical; D006968:Hypersensitivity, Delayed; D007109:Immunity / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008970:Molecular Weight
D000276:Adjuvants, Immunologic; D000941:Antigens; D004318:Doxycycline
Mnogofaktornyĭ analiz pokazateleĭ immuniteta pri kombinirovannom deĭstvii doksitsiklina i nizkomolekuliarnogo immunomoduliatora mikrobnogo proiskhozhdeniia.