title: The molecular basis of HbH disease in Taiwan.
abstract: We have determined the molecular characteristics of alpha-thalassemia in 12 HbH subjects from Taiwan by restriction endonuclease mapping with alpha- and zeta-specific probes. We have found four types of defects in the alpha-thalassemia-2 genetic determinant: -alpha 3.7 type I; -alpha 4.2; alpha CS alpha; and alpha alpha T. All HbH subjects carried the --SEA genotype in the alpha-thalassemia-1 determinant. At least two different subtypes of --SEA genotype were observed in this study.
authors.affiliation: Department of Medicine, Veterans General Hospital, Taipei, Taiwan, Republic of China.
authors.forename: H W
authors.initials: HW
authors.lastname: Peng
authors.forename: S H
authors.initials: SH
authors.lastname: Han
authors.forename: T Y
authors.initials: TY
authors.lastname: Chow
authors.forename: C H
authors.initials: CH
authors.lastname: Ho
authors.forename: K N
authors.initials: KN
authors.lastname: Ching
authors.forename: B N
authors.initials: BN
authors.lastname: Chiang
mesh_terms: D004262:DNA Restriction Enzymes; D005838:Genotype; D006447:Hemoglobin H / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D013624:Taiwan; D013789:Thalassemia / Q000235:genetics*
chemical_list: D006455:Hemoglobins, Abnormal; D006447:Hemoglobin H; D004262:DNA Restriction Enzymes