title: Antineural autoantibodies in patients with paraneoplastic cerebellar degeneration.
abstract: We studied serum autoantibodies from six patients with paraneoplastic cerebellar degeneration using rat brains. Immunohistochemically, serum samples from four of six patients with uterine or ovarian tumors showed a similar staining pattern, labeling Purkinje cells and various other neurons distributed throughout the brain and spinal cord. The immunoblot study showed that these serum samples recognized the common 52-kd band. Serum from a patient with duct carcinoma of the breast reacted with the 46-kd band with a similar but weaker immunohistochemical reactivity. Serum from another patient with small-cell carcinoma of the lung in whom paraneoplastic cerebellar degeneration and Eaton-Lambert myasthenic syndrome developed recognized the 40-kd and 38-kd bands with a different immunostaining pattern. Autoantibodies in patients with paraneoplastic cerebellar degeneration are directed to a variety of neuronal antigens that may differ from patient to patient.
authors.affiliation: Department of Neurology, Fukushima Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: O
authors.initials: O
authors.lastname: Yoshie
authors.forename: H
authors.initials: H
authors.lastname: Terunuma
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D002490:Central Nervous System / Q000276:immunology* / Q000473:pathology; D002524:Cerebellar Ataxia / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000276:immunology* / Q000473:pathology; D014594:Uterine Neoplasms / Q000276:immunology
chemical_list: D001323:Autoantibodies