title: Interferon-gamma induces class II MHC antigens on RINm5F cells.
abstract: The ability of recombinant interferon-gamma (rIFN-gamma) to induce major histocompatibility complex (MHC) antigen expression in the rat insulinoma cell line RINm5F was investigated. The cells were stained with monoclonal antibodies specific for rat class I and class II MHC antigens. RINm5F cells endogenously expressed class I antigens; this was enhanced by rIFN-gamma. Class II antigens could not be detected on RINm5F cells, but both I-A and I-E were induced by rIFN-gamma.
authors.affiliation: Department of Immunology, Middlesex Hospital Medical School, London, England.
authors.forename: A M
authors.initials: AM
authors.lastname: Varey
authors.forename: P M
authors.initials: PM
authors.lastname: Lydyard
authors.forename: B M
authors.initials: BM
authors.lastname: Dean
authors.forename: P H
authors.initials: PH
authors.lastname: Van der Meide
authors.forename: J D
authors.initials: JD
authors.lastname: Baird
authors.forename: A
authors.initials: A
authors.lastname: Cooke
mesh_terms: D007516:Adenoma, Islet Cell / Q000276:immunology*; D000818:Animals; D000911:Antibodies, Monoclonal; D002460:Cell Line; D006680:HLA Antigens / Q000145:classification / Q000276:immunology*; D007340:Insulinoma / Q000276:immunology* / Q000473:pathology; D007371:Interferon-gamma / Q000276:immunology*; D010190:Pancreatic Neoplasms / Q000276:immunology* / Q000473:pathology; D011994:Recombinant Proteins
chemical_list: D000911:Antibodies, Monoclonal; D006680:HLA Antigens; D011994:Recombinant Proteins; D007371:Interferon-gamma