Rings, dicentrics, and telomeric association in histiocytomas.
We report clonal karyotypic abnormalities in six of 12 cytogenetically investigated malignant fibrous histiocytomas. Four of eight tumors of the pleomorphic subtype had complex clonal chromosome aberrations, including ring chromosomes, dicentric chromosomes, and/or telomeric associations. No common characteristic aberration could be distinguished. Two of four myxoid tumors had clonal changes: One had one to two ring chromosomes and an extra chromosome #2; another had a supernumerary ring chromosome as the sole abnormality.
Mandahl
N
N
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Heim
S
S
Arheden
K
K
Rydholm
A
A
Willén
H
H
Mitelman
F
F
D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000235:genetics / Q000473:pathology; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D005819:Genetic Markers; D018219:Histiocytoma, Benign Fibrous / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D012303:Ring Chromosomes; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology
D005819:Genetic Markers