Relationship between the serum levels of calcitonin, calcium, phosphorus and red blood cell Ca-ATPase during calcium infusion to healthy volunteers.
The relationship between the serum levels of calcitonin (CT), Ca and P, and red blood cell Ca-ATPase (RBC Ca-ATPase) was investigated during Ca infusion given to 6 healthy volunteers. The following results were obtained: Ca infusion, during a 3-hour period, raised serum levels of CT, P and RBC Ca-ATPase with significant correlations between serum CT and RBC Ca-ATPase. The increase in RBC Ca-ATPase activity was accompanied by an appropriate decrease in K-Na-ATPase activity. This study supports the in vitro observations concerning the regulation of intracellular Ca level by CT. Activation of Ca-ATPase during Ca loading is important for red cell survival.
Shainkin-Kestenbaum
R
R
Department of Nephrology, Soroka University Hospital, Beer Sheva, Israel.
Zimlichman
S
S
Liel
Y
Y
D000328:Adult; D002116:Calcitonin / Q000097:blood*; D002118:Calcium / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D002125:Calcium Gluconate / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D008297:Male; D010758:Phosphorus / Q000097:blood*; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood
D010758:Phosphorus; D002116:Calcitonin; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D002125:Calcium Gluconate; D002118:Calcium