Lack of effect of fish oil-enriched diet on experimental allergic neuritis in Lewis rats.
Lewis rats were maintained on a diet enriched with menhaden oil, a rich source of the arachidonic acid (AA) substitute eicosapentaenoic acid (EPA). After dietary manipulation the blood neutrophils showed normal leukotriene (LT)B4 but increased LTB5 concentrations, and the CD4+/CD8+T lymphocyte subset ratio was temporarily perturbed. The dietary manipulation did not affect the severity of actively induced experimental allergic neuritis (EAN).
Taylor
W A
WA
Department of Neurology, United Medical School, Guy's Hospital, London, U.K.
Hughes
R A
RA
Lee
T
T
D000818:Animals; D004041:Dietary Fats / Q000627:therapeutic use*; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives / Q000097:blood; D005395:Fish Oils / Q000627:therapeutic use*; D007958:Leukocyte Count; D007975:Leukotriene B4 / Q000097:blood / Q000031:analogs & derivatives; D009444:Neuritis, Autoimmune, Experimental / Q000097:blood / Q000178:diet therapy* / Q000276:immunology; D009504:Neutrophils / Q000032:analysis; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000145:classification
D004041:Dietary Fats; D005395:Fish Oils; C033266:Menhaden oil; D007975:Leukotriene B4; C040212:leukotriene B5; D015118:Eicosapentaenoic Acid