title: Malignant fibrous histiocytoma in childhood: a report of two cases and review of the literature.
abstract: Malignant fibrous histiocytoma (MFH) is a tumor of late adult life not often recognized as occurring in children. Our search of the English literature produced only 27 well-documented examples occurring in the soft tissues, to which we here add 2 additional cases. Both of our cases displayed the classical storiform-pleomorphic histologic pattern typical of such tumors in adults, and both pursued a malignant and rapidly fatal course. Previous reports of this tumor in children are reviewed, and the differential diagnostic considerations briefly discussed. Overall, the clinical features of MFH in children are similar to those reported in adults, and surgical removal remains the key element of successful therapy.
authors.affiliation: Department of Pathology, Children's Hospital, Denver, Colorado 80218.
authors.forename: C W
authors.initials: CW
authors.lastname: Zuppan
authors.forename: G W
authors.initials: GW
authors.lastname: Mierau
authors.forename: H L
authors.initials: HL
authors.lastname: Wilson
mesh_terms: D002648:Child; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology*; D006801:Humans; D007223:Infant; D008297:Male; D012983:Soft Tissue Neoplasms / Q000473:pathology*