title: Modulation of atrial natriuretic peptide-induced cGMP accumulation by [Arg8]vasopressin in the cultured renal epithelial cell line, LLC-PK1.
abstract: Atrial natriuretic peptide (ANP) III stimulated the formation of intracellular cGMP in renal epithelial cells (LLC-PK1) dose dependently. Incubation of LLC-PK1 cells with [Arg8]vasopressin resulted in an increase in intracellular cAMP levels. The stimulatory effect of ANP III on the cyclic cGMP system was inhibited by coincubation with [Arg8]vasopressin in a dose-dependent manner.
authors.affiliation: Bayer AG, Analytical Therapy Research, Department of Pharmacology, Wuppertal, F.R.G.
authors.forename: D
authors.initials: D
authors.lastname: Neuser
authors.forename: J P
authors.initials: JP
authors.lastname: Stasch
authors.forename: F J
authors.initials: FJ
authors.lastname: Morich
mesh_terms: D001127:Arginine Vasopressin / Q000494:pharmacology*; D009320:Atrial Natriuretic Factor / Q000037:antagonists & inhibitors*; D002460:Cell Line; D006152:Cyclic GMP / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*
chemical_list: D001127:Arginine Vasopressin; D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP