Interstitial pneumonitis following autologous bone marrow transplantation.
Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7%) and CMV IP (2%) in these marrow autograft recipients were lower than the incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT (P less than or equal to 0.001 for both comparisons).
Wingard
J R
JR
Johns Hopkins Oncology Center, Baltimore, Maryland 21205.
Sostrin
M B
MB
Vriesendorp
H M
HM
Mellits
E D
ED
Santos
G W
GW
Fuller
D J
DJ
Braine
H G
HG
Yeager
A M
AM
Burns
W H
WH
Saral
R
R
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications; D005260:Female; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D008223:Lymphoma / Q000628:therapy*; D008297:Male; D011658:Pulmonary Fibrosis / Q000209:etiology*; D012307:Risk Factors; D014777:Virus Diseases / Q000150:complications