title: Leukocyte-induced tissue injury.
abstract: The crucial role of leukocytes in host defense is well known. It is becoming increasingly clear, however, that in addition to their beneficial effects, leukocytes can also cause significant injury to host tissues. In this article, the authors review some of the experimental evidence that supports the role of leukocytes in tissue injury.
authors.affiliation: Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California.
authors.forename: J H
authors.initials: JH
authors.lastname: Jackson
authors.forename: C G
authors.initials: CG
authors.lastname: Cochrane
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000201:enzymology / Q000378:metabolism; D006224:Cricetinae; D004249:DNA Damage; D004285:Dogs; D006801:Humans; D006861:Hydrogen Peroxide / Q000009:adverse effects / Q000378:metabolism; D006878:Hydroxides / Q000009:adverse effects / Q000378:metabolism; D017665:Hydroxyl Radical; D007105:Immune Complex Diseases / Q000276:immunology / Q000473:pathology; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D008171:Lung Diseases / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology / Q000378:metabolism; D008253:Macaca mulatta; D009504:Neutrophils / Q000201:enzymology / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption; D010196:Pancreatic Elastase / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013481:Superoxides / Q000009:adverse effects / Q000378:metabolism
chemical_list: D006878:Hydroxides; D013481:Superoxides; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide; D010196:Pancreatic Elastase; D010100:Oxygen