title: Dopamine denervation of the nucleus accumbens induces a selective increase in the number of delta-opioid binding sites.
abstract: Selective lesions of dopamine (DA) neurons of the nucleus accumbens were made in rats by local injections of 6-hydroxydopamine (6-OHDA). Seven days after 6-OHDA, the binding affinities and capacities at mu-, delta- and kappa-opioid binding sites were determined in the nucleus accumbens by selective labelling techniques. 6-OHDA pretreatment caused a significant increase in the number of delta-opioid binding sites (+30%) while the number of mu-, kappa- and total sites was not modified. The affinity at mu-, delta- and kappa-sites was unchanged after 6-OHDA pretreatment.
authors.affiliation: Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Esposito
authors.forename: L
authors.initials: L
authors.lastname: Cervo
authors.forename: P
authors.initials: P
authors.lastname: Petrillo
authors.forename: M
authors.initials: M
authors.lastname: Sbacchi
authors.forename: A
authors.initials: A
authors.lastname: Tavani
authors.forename: R
authors.initials: R
authors.lastname: Samanin
mesh_terms: D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D003714:Denervation; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism*; D016627:Oxidopamine; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism*; D012686:Septal Nuclei / Q000378:metabolism*
chemical_list: D006892:Hydroxydopamines; D011957:Receptors, Opioid; D016627:Oxidopamine