title: Serologic studies of MS patients, controls, and patients with other neurologic diseases: antibodies to HTLV-I, II, III.
abstract: We have studied the frequency of human retrovirus antibody (HTLV-I, II, III) in the serum and CSF of patients with MS, matched controls, and patients with optic neuritis, idiopathic and postencephalitic Parkinson's disease, neuropathies, polymyositis, ALS, and postpoliomyelitis. Except for the postpoliomyelitis samples, all samples were collected prior to 1980. Contrary to a previous published report, no significant levels of antibody to HTLV-I, II, or III were found in the MS patients or controls. No retrovirus antibody was detected in patients with the other neurologic diseases.
authors.affiliation: National Institute of Neurological and Communicative Disorders and Stroke, MD 20892.
authors.forename: D L
authors.initials: DL
authors.lastname: Madden
authors.forename: F K
authors.initials: FK
authors.lastname: Mundon
authors.forename: N R
authors.initials: NR
authors.lastname: Tzan
authors.forename: D A
authors.initials: DA
authors.lastname: Fuccillo
authors.forename: M C
authors.initials: MC
authors.lastname: Dalakas
authors.forename: V
authors.initials: V
authors.lastname: Calabrese
authors.forename: T S
authors.initials: TS
authors.lastname: Elizan
authors.forename: J L
authors.initials: JL
authors.lastname: Sever
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis*; D017977:Deltaretrovirus / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology*; D009422:Nervous System Diseases / Q000276:immunology*; D012016:Reference Values
chemical_list: D000914:Antibodies, Viral; D015483:HIV Antibodies