Biochemically silent posttransfusion non-A, non-B hepatitis interferes with superinfection by hepatitis A virus.
Superinfection of a silently non-A, non-B (NANB)-infected chimpanzee with hepatitis A virus (HAV) resulted in minimal liver enzyme elevations, lack of detectable HAV in stool, and questionable presence of HAV antigen in liver biopsy specimens obtained during the expected period of virus replication. Our findings indicate that even biochemically silent NANB hepatitis can strongly interfere with infection by at least one other hepatotrophic virus.
Bradley
D W
DW
Hepatitis Branch, Center for Infectious Diseases, Atlanta, Ga. 30333.
Krawczynski
K
K
Humphrey
C D
CD
McCaustland
K A
KA
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D006506:Hepatitis A / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D006526:Hepatitis C / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006507:Hepatovirus / Q000276:immunology / Q000502:physiology; D008099:Liver / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D002679:Pan troglodytes; D014779:Virus Replication
D000956:Antigens, Viral; D000410:Alanine Transaminase