title: Acute alkalosis, but not acute hypocalcemia, increases panic behavior in an animal model.
abstract: Non-pretrained, randomized adult rats were tested in a panic-inducing model of passive avoidance. Intravenous treatment with alkalinizing agents (sodium lactate 0.5 M, 0.5 ml/100 g b.wt., or NaHCO3, 0.5 mEq/100 g b.wt.), but not with a hypocalcemic dose of EDTA (75 mg/kg) 3 min before testing, significantly increased panic behavior. These data may support the hypothesis that panic attacks are due to alkalosis and not to lactate-induced hypocalcemia.
authors.affiliation: Institute of Pharmacology, University of Modena, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Di Lorenzo
authors.forename: M
authors.initials: M
authors.lastname: Bernardi
authors.forename: S
authors.initials: S
authors.lastname: Genedani
authors.forename: E
authors.initials: E
authors.lastname: Zirilli
authors.forename: G
authors.initials: G
authors.lastname: Grossi
authors.forename: G P
authors.initials: GP
authors.lastname: Guaraldi
authors.forename: A
authors.initials: A
authors.lastname: Bertolini
mesh_terms: D000471:Alkalosis / Q000523:psychology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001639:Bicarbonates / Q000494:pharmacology; D005239:Fear / Q000502:physiology*; D005260:Female; D006996:Hypocalcemia / Q000523:psychology*; D007773:Lactates / Q000494:pharmacology; D019344:Lactic Acid; D010200:Panic / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000494:pharmacology; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D007773:Lactates; D019344:Lactic Acid; D017693:Sodium Bicarbonate; D012964:Sodium