Tumor-promoting activity of extracts of human semen in SENCAR mice.
Application of ether extracts of pooled human semen that induce Epstein-Barr virus (EBV) activation promoted skin tumor production in female SENCAR mice previously treated with 100 micrograms of 7, 12-dimethylbenz(a)anthracene (DMBA). Twice-weekly applications of 60 micrograms ether extract samples produced papillomas in SENCAR mice. Several samples of human semen were tested to determine the relationship between tumor-promoting activity and EBV activation in human semen. Pooled human semen that induced more than 10% EBV activation effectively promoted tumor production, but samples that induced less than 0.1% EBV activation were ineffective.
Tokuda
H
H
Department of Microbiology, Faculty of Medicine, Kyoto University, Japan.
Ito
Y
Y
Kanaoka
T
T
Yoshida
O
O
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002472:Cell Transformation, Viral / Q000187:drug effects*; D003043:Cocarcinogenesis; D005260:Female; D004854:Herpesvirus 4, Human / Q000254:growth & development*; D006801:Humans; D051379:Mice; D012661:Semen / Q000032:analysis*; D012878:Skin Neoplasms / Q000139:chemically induced*; D014775:Virus Activation / Q000187:drug effects*
D015127:9,10-Dimethyl-1,2-benzanthracene