title: [Characteristics of mutagenesis induced by nitrosomethylurea in a mammalian multilocus system in vitro].
abstract: The mutagenic effect of short- and long-term MNU exposition causing alkylation and that combined with carbamoylation, correspondingly, at the four specific gene loci of the CHO-AT3-2 Chinese hamster line was studied. The increase both in MNU mutagenic effects and in the range of induced changes resulted from intensification of carbamoylating processes. True point mutations occurred mainly on alkylation. When carbamoylation is increased, the quantity and variety of mutations change towards accumulation of the number of other genetic lesions, for example, frameshift mutations and deletions.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Pashin
authors.forename: L E
authors.initials: LE
authors.lastname: Sal'nikova
authors.forename: V I
authors.initials: VI
authors.lastname: Kozachenko
mesh_terms: D000228:Adenine Phosphoribosyltransferase / Q000235:genetics; D000478:Alkylation; D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D006224:Cricetinae; D005796:Genes / Q000187:drug effects*; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D008770:Methylnitrosourea / Q000494:pharmacology*; D009154:Mutation; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics; D013937:Thymidine Kinase / Q000235:genetics; D013997:Time Factors
chemical_list: D008770:Methylnitrosourea; D000228:Adenine Phosphoribosyltransferase; D007041:Hypoxanthine Phosphoribosyltransferase; D013937:Thymidine Kinase; D000254:Sodium-Potassium-Exchanging ATPase
vernacular_title: Osobennosti mutageneza, indutsiruemogo nitrozometilmochevinoĭ v mnogolokusnoĭ sisteme in vitro u mlekopitaiushchikh.