Tobacco smokers' neutrophils are desensitized to chemotactic peptide-stimulated oxygen uptake.
Chemotactic peptide-stimulated oxygen uptake and superoxide release were measured in neutrophils from a group of age- and race-matched male tobacco smokers and nonsmokers. The stimulated oxygen uptake in smokers was less than that of nonsmokers. This decreased sensitivity to formyl-methionyl-leucyl-phenylalanine (FMLP) stimulation of O2 uptake was the result of an altered apparent Km and was paralleled by a decrement in superoxide release in smokers. These alterations in neutrophil function, coupled with our previous observation of altered tritiated FMLP binding in smokers, support the hypothesis of a modified response to FMLP in chronic smoker's neutrophils.
Codd
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Department of Oral Biology and Medicine, University of Kentucky Medical Center, Lexington.
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D000328:Adult; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology*; D009504:Neutrophils / Q000378:metabolism*; D010101:Oxygen Consumption; D012907:Smoking / Q000097:blood*; D013481:Superoxides / Q000097:blood
D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine