Alterations of class I HLA genes in human colon cancers.
Alterations of HLA class I genes were found in 3 of 12 human colon cancers. Rearrangements in HLA class I genes were observed in 2 cancers and amplification of HLA-coding genes was observed in 1 cancer. All 3 cancers were at an advanced stage. No examples of amplification or rearrangement in the HLA genes were found in 10 other tumours of diverse types. No alterations in the beta 2-microglobulin gene were observed in 22 human solid tumours included in this study. The association between alterations in HLA genes and proto-oncogenes in these tumours is discussed.
Bar-Eli
M
M
Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
Battifora
H
H
Cline
M J
MJ
D000230:Adenocarcinoma / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005784:Gene Amplification; D005819:Genetic Markers; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D011519:Proto-Oncogenes; D001613:beta 2-Microglobulin / Q000235:genetics
D005819:Genetic Markers; D006680:HLA Antigens; D001613:beta 2-Microglobulin; D004247:DNA; D004262:DNA Restriction Enzymes