title: Catalytic activity concentrations of diadenosine tetraphosphate hydrolase in normal and pathological sera.
abstract: The levels of diadenosine tetraphosphate hydrolase, a nucleotide pyrophosphatase (EC 3.6.1.9), were measured in human sera with a bioluminescence method. 40 sera of healthy donors and 207 samples obtained from inpatients of a medical clinic were analysed. About two thirds of the patients showed increased hydrolase levels, as compared to the normal donors. Elevated levels were not specific for a certain disease, and they were found in quite different disorders. There was no indication for a dependency of enzyme activity on age or sex of the patients. The comparison of diadenosine tetraphosphate hydrolase with seven other laboratory parameters revealed a highly significant correlation with gamma-glutamyl transferase, suggesting that the liver may be a source of elevated serum activities. There was evidence that the gastrointestinal tract and the pancreas may also be regarded as possible organ sources of the hydrolase.
authors.affiliation: Institut für Physiologische Chemie der Universität Erlangen-Nürnberg.
authors.forename: J
authors.initials: J
authors.lastname: Lüthje
authors.forename: A
authors.initials: A
authors.lastname: Holler
authors.forename: A
authors.initials: A
authors.lastname: Ogilvie
authors.forename: W
authors.initials: W
authors.lastname: Siegfried
authors.forename: A
authors.initials: A
authors.lastname: Waldherr
authors.forename: W
authors.initials: W
authors.lastname: Domschke
mesh_terms: D017766:Acid Anhydride Hydrolases; D000328:Adult; D002384:Catalysis; D005260:Female; D006801:Humans; D008297:Male; D010744:Phosphoric Monoester Hydrolases / Q000097:blood*
chemical_list: D010744:Phosphoric Monoester Hydrolases; D017766:Acid Anhydride Hydrolases; C020023:bis(5'-nucleosyl)tetraphosphatase (asymmetrical)