Clinical isolate of Citrobacter freundii highly resistant to new quinolones.
About 30% of 150 recent clinical isolates of Citrobacter freundii were resistant to greater than or equal to 3.13 micrograms of norfloxacin and ofloxacin per ml. Study of one quinolone-resistant strain for which the norfloxacin MIC was 100 micrograms/ml suggested that resistance was associated with both an altered A subunit of DNA gyrase and reduction in drug uptake accompanied by a decrease in an outer membrane protein.
Aoyama
H
H
Episome Institute, Gunma, Japan.
Fujimaki
K
K
Sato
K
K
Fujii
T
T
Inoue
M
M
Hirai
K
K
Mitsuhashi
S
S
D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism; D002954:Citrobacter / Q000187:drug effects* / Q000235:genetics; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D004352:Drug Resistance, Microbial; D004591:Electrophoresis, Polyacrylamide Gel; D011804:Quinolines / Q000494:pharmacology*
D001425:Bacterial Outer Membrane Proteins; D011804:Quinolines; D004250:DNA Topoisomerases, Type II