title: Growth hormone treatment in adults with growth hormone deficiency: effect on muscle fibre size and proportions.
abstract: The effect of a 6-month period of substitution therapy with recombinant human growth hormone (rhGH) on muscle fibre size and muscle fibre type proportions has been investigated in a group of 13 adults with growth hormone deficiency. All had a peak growth hormone (GH) response to insulin-induced hypoglycaemia of less than 7 mU/l. There was no statistically significant change in the lesser fibre diameter or fibre proportions of either type 1 or type 2 muscle fibres in the rhGH group, as compared with placebo.
authors.affiliation: Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Belfast, Northern Ireland, UK.
authors.forename: H M
authors.initials: HM
authors.lastname: Whitehead
authors.forename: J S
authors.initials: JS
authors.lastname: Gilliland
authors.forename: I V
authors.initials: IV
authors.lastname: Allen
authors.forename: D R
authors.initials: DR
authors.lastname: Hadden
mesh_terms: D000328:Adult; D001823:Body Composition; D005260:Female; D013006:Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects*; D011994:Recombinant Proteins
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone