title: Correlation between serum enzymes and serum unsaturated vitamin B12 binding proteins in primary liver carcinoma.
abstract: The serum unsaturated vitamin B12-binding capacity (UBBC), unsaturated transcobalamin (UTC) I, UTC II, UTC III levels, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase activities and bilirubin concentration were estimated in 61 patients with liver diseases (31 with hepatoma, 30 with viral hepatitis). The levels of serum cobalamin, UTC I, UTC III, UBBC, alanine and aspartate aminotransferases, and bilirubin were raised in both hepatoma and viral hepatitis patients. Serum UTC II was reduced in both conditions. Alkaline phosphatase activity was significantly increased in hepatoma. Four significant correlations were observed among these parameters in the hepatoma patients while only one significant correlation was observed in viral hepatitis.
authors.affiliation: Laboratory of Medical Biochemistry, Inserm U 308, Faculty of Medicine, University of Nancy, Vandoeuvre-Les-Nancy, France.
authors.forename: B O
authors.initials: BO
authors.lastname: Osifo
authors.forename: A
authors.initials: A
authors.lastname: Ayoola
authors.forename: Y
authors.initials: Y
authors.lastname: Parmentier
authors.forename: P
authors.initials: P
authors.lastname: Gerard
authors.forename: J P
authors.initials: JP
authors.lastname: Nicolas
mesh_terms: D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000201:enzymology*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000097:blood / Q000201:enzymology; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D014155:Transcobalamins / Q000378:metabolism*; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D014155:Transcobalamins; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D014805:Vitamin B 12; D001663:Bilirubin