title: The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon.
abstract: In both humans and mice, two genes encode phosphoglycerate kinase, a key enzyme in the glycolytic pathway. The pgk-1 gene is expressed in all somatic cells, is located on the X chromosome, and contains 10 introns. The pgk-2 gene is expressed only in sperm cells, is located on an autosome, and has no introns. The nucleotide sequence of the pgk-2 gene suggests that it arose from pgk-1 more than 100 million years ago by RNA-mediated gene duplication. The pgk-2 gene may, then, be a transcribed retroposon. Thus, gene duplication by retroposition may have been used as a mechanism for evolutionary diversification.
authors.affiliation: Department of Medicine, University of Ottawa, Canada.
authors.forename: P H
authors.initials: PH
authors.lastname: Boer
authors.forename: C N
authors.initials: CN
authors.lastname: Adra
authors.forename: Y F
authors.initials: YF
authors.lastname: Lau
authors.forename: M W
authors.initials: MW
authors.lastname: McBurney
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005786:Gene Expression Regulation; D005796:Genes; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D010735:Phosphoglycerate Kinase / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D013737:Testis / Q000201:enzymology / Q000502:physiology*; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger; D004247:DNA; D010735:Phosphoglycerate Kinase; D004262:DNA Restriction Enzymes