title: HYLAS: program for generating H curves (abstract three-dimensional representations of long DNA sequences).
abstract: The computer program HYLAS generates from a standard DNA letter sequence a three-dimensional space curve (H curve) which embodies the entire information content of the original nucleotide sequence. The program can display H curves either as two-dimensional (front and side view) projections or as stereo-pair images. The curves can be marked at specific nucleotide locations, annotated, rotated for observation from any viewing angle, and manipulated for convenient side-by-side comparisons. Unlike the cumbersome letter sequences, H curves can be drastically condensed in size without losing their ability to reflect the global nucleotide-distribution pattern of the entire DNA sequence. Often, biologically important loci can be visually identified on the H curves. HYLAS is written in FORTRAN with separate mainframe (IBM-VM/CMS) and microcomputer (MS-DOS) versions. It uses the Tektronix-TCS library of graphic subroutines.
authors.affiliation: Department of Biochemistry, School of Medicine, Tulane University, New Orleans, LA 70112.
authors.forename: E
authors.initials: E
authors.lastname: Hamori
authors.forename: G
authors.initials: G
authors.lastname: Varga
authors.forename: J J
authors.initials: JJ
authors.lastname: LaGuardia
mesh_terms: D001483:Base Sequence; D003196:Computer Graphics; D004247:DNA; D008969:Molecular Sequence Data; D012984:Software
chemical_list: D004247:DNA