title: Metabolic imaging of human extremity musculoskeletal tumors by PET.
abstract: The measurement of glucose utilization rate (GUR) by positron emission tomography (PET) using 18F-2-fluoro-2-deoxy-D-glucose (FDG) is a valuable method to assess the grade of malignancy of brain tumors. We have designed a feasibility trial to determine whether PET could be used to image and predict the grade of malignancy of human extremity musculoskeletal tumors. Five patients with extremity tumors (four soft-tissue tumors and one osteogenic tumor) were studied. Peak and mean apparent GURs were determined in the tumor region. All tumors were subsequently resected and graded in a standard fashion using the NCI grading system. Peak apparent GURs ranged from 3.3 mg/100 g/min to 15.2 mg/100 g/min, with the highest values found in the high grade tumors. Although the number of patients studied was small, a good correspondence was shown between GURs and histopathologic grading. Our results indicate that PET can be used to image and evaluate the metabolic activity of human musculoskeletal tumors.
authors.affiliation: Surgery Branch, NCI, Bethesda, Maryland.
authors.forename: K A
authors.initials: KA
authors.lastname: Kern
authors.forename: A
authors.initials: A
authors.lastname: Brunetti
authors.forename: J A
authors.initials: JA
authors.lastname: Norton
authors.forename: A E
authors.initials: AE
authors.lastname: Chang
authors.forename: M
authors.initials: M
authors.lastname: Malawer
authors.forename: E
authors.initials: E
authors.lastname: Lack
authors.forename: R D
authors.initials: RD
authors.lastname: Finn
authors.forename: S A
authors.initials: SA
authors.lastname: Rosenberg
authors.forename: S M
authors.initials: SM
authors.lastname: Larson
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005260:Female; D005266:Femoral Neoplasms / Q000000981:diagnostic imaging*; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005870:Giant Cell Tumors / Q000000981:diagnostic imaging; D018219:Histiocytoma, Benign Fibrous / Q000000981:diagnostic imaging; D006801:Humans; D007866:Leg; D008080:Liposarcoma / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009455:Neurofibroma / Q000000981:diagnostic imaging; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose