title: The stability of chromosomes in yeast.
abstract: CL mutants with high instability of chromosome III were UV-induced in haploid strain disomic for chromosome III. The obtained CL mutants can be divided into two groups: (1) CL2, CL3, CL7, CL11-CL13 with elevated level of spontaneous inter- and intragenic recombination and (2) CL4, CL8 in which instability of chromosome III is not accompanied by elevation of mitotic recombination frequency. CL4 and CL8 mutants also show unstable maintenance of artificial minichromosomes with different chromosomal replicators and centromeric loci. The instability of chromosome III and minichromosomes in CL4 and CL8 is determined by two nonallelic genes designated ch14 and ch18. The role of ch14 and ch18 genes in mitotic chromosome transmission is discussed.
authors.affiliation: Institute of Cytology, Academy of Sciences of the USSR, Leningrad.
authors.forename: V L
authors.initials: VL
authors.lastname: Larionov
authors.forename: T S
authors.initials: TS
authors.lastname: Karpova
authors.forename: G A
authors.initials: GA
authors.lastname: Zhouravleva
authors.forename: O B
authors.initials: OB
authors.lastname: Pashina
authors.forename: N T
authors.initials: NT
authors.lastname: Nikolaishvili
authors.forename: N Y
authors.initials: NY
authors.lastname: Kouprina
mesh_terms: D002875:Chromosomes / Q000648:ultrastructure*; D003433:Crosses, Genetic; D004262:DNA Restriction Enzymes; D008938:Mitosis; D009154:Mutation; D010957:Plasmids; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics* / Q000648:ultrastructure
chemical_list: D004262:DNA Restriction Enzymes