title: Relationship between epileptic activity and edema formation in the acute phase of cryogenic lesion.
abstract: Following cryogenic lesions of the brain in the rabbit, ictal activity appears within min with a maximum at 2 h. Brain edema increases rapidly between 2-4 h with a maximum at 8 h. The glutamate concentration reaches 209% of control in the perilesional area at 2 h and the time course of glutamate/GABA ratio parallels the time course of epileptic activity. The impairment of Na+-K+-ATPase activity (rise of KMapp for K+) in the glial fraction coincides with the increase of edema. A positive correlation is found between the total amount of ictal activity and the total amount of edema in individual animals, suggesting that epilepsy may enhance edema formation.
authors.affiliation: Istituto di Farmacologia, Facoltà di Scienze, Università di Pavia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Arrigoni
authors.forename: N
authors.initials: N
authors.lastname: Averet
authors.forename: H
authors.initials: H
authors.lastname: Loiseau
authors.forename: F
authors.initials: F
authors.lastname: Cohadon
mesh_terms: D000818:Animals; D001929:Brain Edema / Q000209:etiology* / Q000503:physiopathology; D003080:Cold Temperature / Q000009:adverse effects*; D004569:Electroencephalography; D004827:Epilepsy / Q000209:etiology / Q000503:physiopathology*; D005971:Glutamates / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism; D011817:Rabbits; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005971:Glutamates; D005680:gamma-Aminobutyric Acid; D000254:Sodium-Potassium-Exchanging ATPase