Antihypertensive activity of enalapril. Effect of ibuprofen and different salt intakes.
It has been suggested that angiotensin-converting enzyme (ACE) inhibitors may also act through the renal prostaglandin (PG) system; moreover, it has been shown that nonsteroidal antiinflammatory drugs (NSAIDs) are capable of reducing the antihypertensive activity of ACE inhibitors. Sixteen essential hypertensive patients (WHO stages, I-II, eight on a low-sodium diet and eight on a high-sodium diet) were treated with enalapril, 20 mg/day per os, for 4 days. On days 3 and 4, ibuprofen, 1,200 mg/day per os, was also given. Enalapril reduced blood pressure, particularly in the group on the low-sodium diet. Urinary 6-keto-PGF1 alpha, an indicator of renal PGI2 production (determined by HPLC-RIA), increased in the first few hours after enalapril in the low-sodium group. Ibuprofen did not reduce the antihypertensive effect of enalapril, nor did it affect plasma renin activity or plasma aldosterone. Only a slight reduction in 6-keto-PGF1 alpha excretion was observed after enalapril plus ibuprofen. It is suggested that the effect of enalapril on urinary 6-keto-PGF1 alpha excretion is largely dependent on factors such as sodium intake.
Minuz
P
P
Clinica Medica, University of Verona, Policlinico Borgo Roma, Italy.
Lechi
A
A
Arosio
E
E
Degan
M
M
Capuzzo
M G
MG
Lechi
C
C
Corsato
M
M
Dalla Riva
A
A
Velo
G P
GP
D015121:6-Ketoprostaglandin F1 alpha / Q000652:urine; D000328:Adult; D000450:Aldosterone / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D004656:Enalapril / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007052:Ibuprofen / Q000008:administration & dosage*; D007610:Kallikreins / Q000652:urine; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood; D012982:Sodium, Dietary / Q000008:administration & dosage*
D000806:Angiotensin-Converting Enzyme Inhibitors; D012982:Sodium, Dietary; D000450:Aldosterone; D015121:6-Ketoprostaglandin F1 alpha; D004656:Enalapril; D007610:Kallikreins; D012083:Renin; D007052:Ibuprofen