Apneustic respiration of ketamine is not antagonized by naloxone in the cat.
We investigated the hypothesis that ketamine-induced respiratory depression might be mediated through the opiate system that can be eliminated by naloxone. The steady-state respiratory responses to i.v. ketamine (2 mg.ml-1.kg-1) and their antagonism by naloxone (0.4 mg.ml-1.kg-1) were studied in anesthetized, paralyzed, vagotomized, and artificially ventilated cats. We found that ketamine depressed central respiratory output, assessed from the phrenic nerve electroneurogram, leading to apneustic breathing, which was not antagonized by naloxone. The apneustic respiratory depression by ketamine was thus mediated through mechanism other than the opiate system.
Pokorski
M
M
Department of Neurophysiology, Polish Academy of Sciences Medical Research Center, Warsaw, Poland.
Sieradzan
B
B
Karczewski
W
W
D000818:Animals; D001049:Apnea / Q000139:chemically induced; D002415:Cats; D007649:Ketamine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology; D012119:Respiration / Q000187:drug effects*
D011957:Receptors, Opioid; D009270:Naloxone; D007649:Ketamine