[The virus-inactivating effect of inorganic peroxy compounds].
The inactivating effect of the anorganic peroxy compounds percarbonate and H2O2 on poliovirus is described. In addition, the reaction mechanism of these peroxy compounds with poliovirus was investigated. It was shown that the inactivation of free nucleic acid required similar (H2O2) or lower concentrations (percarbonate) than the inactivation of virus particles. After incubation with anorganic peroxy compounds the virus was not destroyed completely; though sufficiently inactivated, a rest of "intact" virus particles was demonstrated by ultracentrifugation in sucrose gradients.
Sporkenback-Höffler
J
J
Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg.
Meyer-Pannwitt
K
K
Dernick
R
R
D002254:Carbonates / Q000494:pharmacology*; D002499:Centrifugation, Density Gradient; D006367:HeLa Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D017955:Poliovirus / Q000187:drug effects* / Q000235:genetics; D012367:RNA, Viral / Q000187:drug effects*; D014775:Virus Activation / Q000187:drug effects
D002254:Carbonates; D012367:RNA, Viral; D006861:Hydrogen Peroxide; C034738:sodium percarbonate
Die virusinaktivierende Wirkung von anorganischen Peroxyverbindungen.