title: Termination of pregnancy by a dilatation-evacuation technique to obtain placental tissue for DNA analysis.
abstract: In 57 patients, following prenatal diagnosis of a fetus affected by beta-thalassaemia major, we terminated the pregnancy by dilatation and evacuation. In 19, we have already performed DNA analysis to evaluate the feasibility of prenatal diagnosis in a subsequent pregnancy.
authors.affiliation: Laboratorio di Ricerche Cliniche, Istituti Clinici di Perfezionamento, Milano, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Ferrari
authors.forename: A
authors.initials: A
authors.lastname: Cantù-Rajnoldi
authors.forename: S
authors.initials: S
authors.lastname: Pietri
authors.forename: M
authors.initials: M
authors.lastname: Buscaglia
authors.forename: U
authors.initials: U
authors.lastname: Nicolini
mesh_terms: D000028:Abortion, Induced; D002824:Chorionic Villi / Q000032:analysis; D004247:DNA / Q000032:analysis* / Q000378:metabolism; D004262:DNA Restriction Enzymes / Q000378:metabolism; D005260:Female; D006801:Humans; D010920:Placenta / Q000032:analysis* / Q000648:ultrastructure; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis; D013396:Suction; D013789:Thalassemia / Q000175:diagnosis
chemical_list: D004247:DNA; D004262:DNA Restriction Enzymes