title: The onset of senescence is affected by DNA rearrangements of a discontinuous mitochondrial gene in Podospora anserina.
abstract: Mapping and transcription studies have revealed that in Podospora anserina the causative agent of senescence, a mitochondrial plasmid (plDNA), is identical with intron 1 of the discontinuous gene for cytochrome-c-oxidase subunit 1 (COI), which is 2 kpb from the discontinuous gene for cytochrome b (Cytb). A mitochondrial mutant (ex1) devoid of the COI, but not of the Cytb gene provides longevity. A molecular model for the onset of senescence is presented.
authors.affiliation: Lehrstuhl für Allgemeine Botanik, Ruhr-Universität Bochum, Federal Republic of Germany.
authors.forename: U
authors.initials: U
authors.lastname: Kück
authors.forename: H D
authors.initials: HD
authors.lastname: Osiewacz
authors.forename: U
authors.initials: U
authors.lastname: Schmidt
authors.forename: B
authors.initials: B
authors.lastname: Kappelhoff
authors.forename: E
authors.initials: E
authors.lastname: Schulte
authors.forename: U
authors.initials: U
authors.lastname: Stahl
authors.forename: K
authors.initials: K
authors.lastname: Esser
mesh_terms: D000595:Amino Acid Sequence; D001203:Ascomycota / Q000235:genetics*; D001483:Base Sequence; D003573:Cytochrome b Group / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D003576:Electron Transport Complex IV / Q000235:genetics*; D005796:Genes; D005800:Genes, Fungal; D008969:Molecular Sequence Data; D014158:Transcription, Genetic; D013098:Xylariales / Q000235:genetics*
chemical_list: D003573:Cytochrome b Group; D004272:DNA, Mitochondrial; D003576:Electron Transport Complex IV