The pharmacological properties of 1,4-dihydro-1-ethyl-7-phenylpyrrol (1,2-a)-pyrimidine-4-one, a new antipyretic and analgesic drug.
The antipyretic, analgesic, antinflammatory and antiulcerogenic properties of a new compound 1,4 dihydro-1-ethyl-7-phenylpyrrol (1,2-a)-pyrimidine-4-one (V33) are described. V33 on a mg/kg basis possesses antipyretic and analgesic properties at doses lower than paracetamol and which do not produce hypothermia or motor impairment. V33 possesses antiinflammatory activity and decreases the production of LTB4 from inflammatory exudates without affecting PGE2 content. V33 is not only devoid of gastric ulcerogenic properties but exerts antiulcer activity toward various ulcerogenic stimuli. Lethal dose 50% (LD50) of V33 is higher that of paracetamol.
Evangelista
S
S
Pharmacology Department, Menarini Pharmaceuticals, Florence, Italy.
Pirisino
R
R
Perretti
F
F
Fantozzi
R
R
Brunelleschi
S
S
Malmberg-Aiello
P
P
Bartolini
A
A
D000700:Analgesics / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D016227:Benzoquinones; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000517:prevention & control; D006801:Humans; D066298:In Vitro Techniques; D007975:Leukotriene B4 / Q000096:biosynthesis; D008297:Male; D051379:Mice; D010101:Oxygen Consumption / Q000187:drug effects; D011744:Pyrimidinones / Q000494:pharmacology* / Q000633:toxicity; D011809:Quinones / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016227:Benzoquinones; D011744:Pyrimidinones; D011809:Quinones; C054908:1,4-dihydro-1-ethyl-7-phenylpyrrol(1,2-a)-pyrimidine-4-one; D007975:Leukotriene B4; C029322:phenylbenzoquinone