title: Atrial natriuretic factor receptors.
abstract: All of the actions of atrial natriuretic factor (ANF) can be explained on the basis of ANF's interaction with specific receptors on the plasma membrane of cells in target tissues. These receptors have been identified. Binding to these receptors by ANF is time dependent and specific and occurs with high affinity. Numerous analogues of ANF have been synthesized, and in general, their affinity for ANF receptors corresponds closely to their potency in vitro and in vivo. Considerable progress has been made in physicochemically characterizing ANF receptors by photoaffinity labeling and affinity cross-linking techniques.
authors.affiliation: Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania.
authors.forename: J W
authors.initials: JW
authors.lastname: Jacobs
authors.forename: G P
authors.initials: GP
authors.lastname: Vlasuk
authors.forename: M
authors.initials: M
authors.lastname: Rosenblatt
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor; D006801:Humans; D017461:Receptors, Atrial Natriuretic Factor; D011956:Receptors, Cell Surface / Q000302:isolation & purification / Q000378:metabolism
chemical_list: D011956:Receptors, Cell Surface; D009320:Atrial Natriuretic Factor; D017461:Receptors, Atrial Natriuretic Factor