Immunohistochemical observation of S-100 protein and neuron specific enolase in the tumour cells of granular cell tumour.
An immunohistochemical technique for the detection of S-100 protein, neuron specific enolase (NSE), carcinoembryonic antigen (CEA) and muramidase (lysozyme) was applied to a case of the granular cell tumour. S-100 protein was detected both in the nuclei and cytoplasma of the granular cells, and NSE was weakly positive in their cytoplasms. CEA and lysozyme were negative in the tumour cells. Our results supports the concept that granular cell tumours are derived from Schwann cells.
Mori
O
O
Department of Dermatology, Kurume University School of Medicine, Japan.
Hachisuka
H
H
Sakamoto
F
F
Nomura
H
H
Sasai
Y
Y
D000328:Adult; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009113:Muramidase / Q000032:analysis; D009379:Neoplasms, Muscle Tissue / Q000032:analysis / Q000201:enzymology; D009442:Neurilemmoma / Q000032:analysis* / Q000201:enzymology / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000032:analysis*; D009418:S100 Proteins / Q000032:analysis*; D012878:Skin Neoplasms / Q000032:analysis* / Q000201:enzymology / Q000473:pathology
D002272:Carcinoembryonic Antigen; D009418:S100 Proteins; D009113:Muramidase; D010751:Phosphopyruvate Hydratase