title: Metabolic studies with diethylene glycol monobutyl ether acetate (DGBA) in the rat.
abstract: 1. The in vitro hydrolysis of DGBA in rat blood and its in vivo metabolism and disposition in male Sprague-Dawley rats were studied. 2. DGBA (5 mM) was hydrolysed in rat blood to diethylene glycol monobutyl ether (DGBE) with a half-life of less than 3 min. 3. 14C-DGBA was rapidly absorbed from the gastrointestinal tract and eliminated predominantly in rat urine within 24 h following oral administration at 200 or 2000 mg/kg. The major urinary metabolite was 2-(2-butoxyethoxy)acetic acid. No unchanged DGBA or DGBE was detected in rat urine at either dose level. 4. No evidence was found for excretion of 2-butoxyacetic acid, which has been shown to exert haematological effects in rats.
authors.affiliation: Health and Environment Laboratories, Eastman Kodak Company, Rochester, NY 14652-3615.
authors.forename: P J
authors.initials: PJ
authors.lastname: Deisinger
authors.forename: D
authors.initials: D
authors.lastname: Guest
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005026:Ethylene Glycols / Q000008:administration & dosage / Q000378:metabolism*; D006868:Hydrolysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005026:Ethylene Glycols; C061482:butyl diglycol acetate