Comparative activity of LY146032 against anaerobic cocci.
Fifty strains of anaerobic gram-positive cocci were tested in vitro against benzylpenicillin, teicoplanin, vancomycin and LY146032. The organisms displayed a wide range of susceptibility to penicillin and the minimum inhibitory concentration for 11 of the strains was greater than or equal to 1 mg penicillin/L. The activity of teicoplanin exceeded that of vancomycin by a factor of two. The activity of LY 146032 varied in different culture media and was dramatically potentiated by the addition of a physiological concentration of calcium. Peptococci were, in general, more susceptible than peptostreptococci to penicillin and to LY146032 in the absence of added calcium.
Greenwood
D
D
Department of Microbiology, University Hospital, Queen's Medical Center, Nottingham, UK.
Palfreyman
J
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D003470:Culture Media; D017576:Daptomycin; D004357:Drug Synergism; D006020:Glycopeptides / Q000494:pharmacology; D006801:Humans; D010400:Penicillin G / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology; D010460:Peptococcus / Q000187:drug effects*; D010462:Peptostreptococcus / Q000187:drug effects*; D017334:Teicoplanin; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D003470:Culture Media; D006020:Glycopeptides; D010455:Peptides; D017334:Teicoplanin; D014640:Vancomycin; D017576:Daptomycin; D010400:Penicillin G; D002118:Calcium