Cytomegalovirus infection in HIV-1-infected individuals.
Urinary excretion of Cytomegalovirus and the presence of serum antibodies against CMV were examined in 79 HIV-1-infected patients at different stages of the disease, as well as in 27 heterosexual and 52 male homosexual controls and correlated to clinical and laboratory results. HIV-1-infected and healthy individuals differed significantly with regard to cutaneous delayed type reactions, absolute numbers of CD4+ cells and CD4+/CD8+ ratios. IgG antibodies against CMV were found in 87% of homosexual and in 52% of heterosexual controls, and in all HIV-1-infected homosexuals. CMV excretion in the urine was exclusively found in HIV-1-infected individuals where the incidence correlated with the CDC-defined disease stage (stage II: 6%, stage III/IV A: 22%, stage IV B/C: 55%). HIV-1-infected patients excreting CMV in the urine also exhibited distinctly decreased numbers of CD4+ cells and significantly decreased CD4+/CD8+ ratios compared to those without CMV viruria.
Süttmann
U
U
Virologische Abteilung, Staatliches Medizinaluntersuchungsamt, Hannover.
Willers
H
H
Gerdelmann
R
R
Höpken
W
W
Schedel
I
I
Deicher
H
H
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology; D000914:Antibodies, Viral / Q000032:analysis; D003586:Cytomegalovirus Infections / Q000209:etiology* / Q000276:immunology; D005260:Female; D006716:Homosexuality; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008297:Male; D012882:Skin Tests; D013601:T-Lymphocytes / Q000145:classification
D000914:Antibodies, Viral