Monoclonal antibody ERY-1 identifies an antigen in erythroid cells, hepatocellular and renal cell carcinomas.
We have identified a monoclonal antibody (ERY-1), which reacts with erythrocytes, erythroid precursor cells, and with embryonal yolk sac, and normal liver and kidney. The antibody also decorates the neoplastic cells of hepatocellular, renal, and yolk sac carcinomas. No reactivity was seen in a variety of other epithelial or mesenchymal neoplasms. It is possible that ERY-1 recognizes an erythropoiesis-associated antigen present in yolk sac, kidney, liver, and bone marrow, all of which are involved in erythropoiesis in various stages of human development. Furthermore, ERY-1 has proved to be extremely useful in the histopathologic diagnosis of hepatocellular and renal cell carcinomas.
Nadji
M
M
Department of Pathology, University of Miami, Jackson Medical Center, Fla.
Matsuo
S
S
Ganjei
P
P
Ziegels-Weissman
J
J
Penneys
N S
NS
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D002292:Carcinoma, Renal Cell / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D004900:Erythroblasts / Q000276:immunology*; D004920:Erythropoiesis; D004921:Erythropoietin / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000175:diagnosis*; D008113:Liver Neoplasms / Q000175:diagnosis*
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D004921:Erythropoietin