Synergistic enhancement of the biliary excretion of cadmium by the simultaneous administration of two dithiocarbamates.
The simultaneous i.p. administration of the two chelating agents bis(2-hydroxyethyl)dithiocarbamate (DEDTC) and 4-carboxamidopiperidinedithiocarbamate (INADTC) to rats given cadmium in their drinking water at a level of 50 mg cadmium/liter for 39 days led to a large synergistic effect on the biliary excretion of cadmium. A much smaller synergistic effect on the urinary excretion of cadmium was also noted. When treated with a similar mixture of chelating agents after a similar cadmium-drinking water exposure of 180 days, rats showed significant decreases in both renal and brain cadmium levels.
Bláha
K
K
Institute of Hygiene and Epidemiology, Prague, Czechoslovakia.
Cikrt
M
M
Kasparová
L
L
Jones
M M
MM
D000818:Animals; D001659:Biliary Tract / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D002104:Cadmium / Q000493:pharmacokinetics*; D002614:Chelating Agents / Q000008:administration & dosage*; D004050:Ditiocarb / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D007668:Kidney / Q000378:metabolism; D010880:Piperidines / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D013859:Thiocarbamates
D002614:Chelating Agents; D010880:Piperidines; D013859:Thiocarbamates; D002104:Cadmium; C040979:4-carboxamidopiperidine-N-dithiocarboxylate; D004050:Ditiocarb; C039353:dihydroxyethyldithiocarbamate