title: Pharmacokinetics of propofol during continuous infusion for pediatric anesthesia.
abstract: The blood concentrations of propofol have been examined during anesthesia by continuous infusion of 12 mg/hg/hr. A bolus dose of 3 mg/kg body weight propofol was used to induce anesthesia. The mean concentrations at apparent steady state were in the range of 4.3 to 5.6 micrograms/ml during the infusion. The mean total body clearance, derived from the apparent steady state concentrations in the blood, was 0.0394 litres/kg/minute. The mean propofol blood concentration at awakening was found to be 2.3 micrograms/ml.
authors.affiliation: Department of Anesthesiology, Katholieke Universiteit Leuven, U.A. Gasthuisberg, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Vandermeersch
authors.forename: J
authors.initials: J
authors.lastname: Van Hemelrijck
authors.forename: G
authors.initials: G
authors.lastname: Byttebier
authors.forename: H
authors.initials: H
authors.lastname: Van Aken
mesh_terms: D000771:Anesthesia, Intravenous; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D015742:Propofol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D015742:Propofol