title: Plasma C3c changes in myasthenia gravis patients receiving high-dose intravenous immunoglobulin during crisis.
abstract: Fast-migrating C3c, a sensitive index of complement activation, was assayed in the plasma of 2 myasthenia gravis (MG) patients in crisis who received high-dose IV immunoglobulin therapy. Dramatic responses were observed in both patients. Clinical improvement paralleled a decrement in C3c levels, suggesting that regulation of complement activation may be one possible mechanism of IV immunoglobulin treatment in MG.
authors.affiliation: Department of Medicine and Biochemistry, Faculty of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand.
authors.forename: N
authors.initials: N
authors.lastname: Kamolvarin
authors.forename: T
authors.initials: T
authors.lastname: Hemachudha
authors.forename: B
authors.initials: B
authors.lastname: Ongpipattanakul
authors.forename: P
authors.initials: P
authors.lastname: Phanuphak
authors.forename: P
authors.initials: P
authors.lastname: Viddayakorn
authors.forename: T
authors.initials: T
authors.lastname: Sueblinvong
mesh_terms: D000293:Adolescent; D000328:Adult; D003176:Complement C3 / Q000032:analysis*; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008297:Male; D009157:Myasthenia Gravis / Q000097:blood* / Q000628:therapy
chemical_list: D003176:Complement C3; D007136:Immunoglobulins