Absorption of drugs from continent caecal reservoir for urine.
The possibility of drug absorption from a continent caecal reservoir for urine was studied in 3 men with well functioning reservoirs. Saline solutions of digoxin, theophylline or terbutaline were instilled into the reservoir, each on a separate occasion, and drug concentrations in plasma and urine were measured for 24 h thereafter. Theophylline, but not terbutaline or digoxin, was absorbed from the reservoir. Estimated from an intravenous reference dose, the uptake of theophylline from the reservoir was approximately 50%. In patients with this type of urinary diversion, therefore, reabsorption from the continent caecal reservoir may complicate drug therapy.
Ekman
I
I
Pharmacokinetics Laboratory, AB DRACO, Lund, Sweden.
Månsson
W
W
Nyberg
L
L
D000368:Aged; D002432:Cecum / Q000378:metabolism / Q000601:surgery; D004077:Digoxin / Q000493:pharmacokinetics*; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D013726:Terbutaline / Q000493:pharmacokinetics*; D013806:Theophylline / Q000493:pharmacokinetics*; D014547:Urinary Diversion
D004077:Digoxin; D013806:Theophylline; D013726:Terbutaline