Distribution of vitamin B12 R-binder in carcinomas of the digestive tract.
To evaluate whether the increase in serum transcobalamin I, seen in patients with carcinoma, is caused by synthesis of R-binder to tumour cells, the distribution of vitamin B12 R-binder in 125 malignant growths of the digestive tract was studied. Positive staining for R-binder with immunoperoxidase was observed in 85 (70%) carcinomas. Positive staining for R-binder was observed in all four cholangiocarcinomas studied, but was absent in nine hepatocellular carcinomas. These findings suggest that determination of R-binder in liver tumours may be of some value in differentiating hepatocellular carcinomas and cholangiocarcinoma, and that synthesis of R-binder by tumour cells causes an increase in serum transcobalamin I.
Kudo
H
H
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Japan.
Ohshio
G
G
Ogawa
K
K
Kim
Y C
YC
Wakatsuki
Y
Y
Nakashima
Y
Y
Yamabe
H
H
Inada
M
M
D000230:Adenocarcinoma / Q000378:metabolism; D002759:Adenoma, Bile Duct / Q000378:metabolism; D001650:Bile Duct Neoplasms / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D004067:Digestive System Neoplasms / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000378:metabolism; D014018:Tissue Distribution; D014155:Transcobalamins / Q000378:metabolism*
D014155:Transcobalamins