title: Immune response to oral polio vaccine in patients with IgA glomerulonephritis.
abstract: Oral poliovirus vaccine was used to immunize 51 patients with IgA glomerulonephritis and 44 healthy controls. The patients showed an enhanced antibody response compared to controls. This was apparent in a higher frequency of strong increases in neutralizing antibody titres during the course of immunization as well as higher levels of virus-specific IgA-class antibodies. IgG-class antibodies showed similar activity in both groups. In patients the neutralizing antibodies correlated with the virus-specific IgA-class antibodies, suggesting that the IgA-antibodies synthesized by the patients are functionally competent antibodies.
authors.affiliation: Department of Biomedical Sciences, University of Tampere, Finland.
authors.forename: P O
authors.initials: PO
authors.lastname: Leinikki
authors.forename: J
authors.initials: J
authors.lastname: Mustonen
authors.forename: A
authors.initials: A
authors.lastname: Pasternack
mesh_terms: D000914:Antibodies, Viral / Q000096:biosynthesis*; D005922:Glomerulonephritis, IGA / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D017955:Poliovirus / Q000276:immunology*; D011055:Poliovirus Vaccine, Oral / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D011055:Poliovirus Vaccine, Oral