N-methyl-D-aspartate (NMDA) receptors control respiratory off-switch in cat.
Functionally active N-methyl-D-aspartate (NMDA) receptors on cat medullary respiratory neurones were revealed by local iontophoretic application of DL-2-amino-7-phosphonoheptanoic acid (AP7). Blockade of NMDA receptors by systemic administration of NMDA antagonists (MK-801, phencyclidine, ketamine, AP7) in vagotomized cats increased the duration of inspiration (Ti) without increasing expiration and caused an apneustic breathing pattern. The increase in Ti which followed systemic MK-801, was accompanied by a shift and complete reversal of early expiratory neuronal discharge in relation to phrenic nerve discharge.
Foutz
A S
AS
Laboratoire de Physiologie Nerveuse, C.N.R.S., Gif-sur-Yvette, France.
Champagnat
J
J
Denavit-Saubié
M
M
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D002415:Cats; D003986:Dibenzocycloheptenes / Q000494:pharmacology; D016291:Dizocilpine Maleate; D007478:Iontophoresis; D007649:Ketamine / Q000494:pharmacology; D016202:N-Methylaspartate; D010069:Oxadiazoles / Q000494:pharmacology; D010622:Phencyclidine / Q000494:pharmacology; D010791:Phrenic Nerve / Q000187:drug effects / Q000502:physiology*; D016318:Quisqualic Acid; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D012119:Respiration; D012125:Respiratory Center / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*
D003986:Dibenzocycloheptenes; D010069:Oxadiazoles; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D001224:Aspartic Acid; D016202:N-Methylaspartate; D007649:Ketamine; D016291:Dizocilpine Maleate; D016318:Quisqualic Acid; D010622:Phencyclidine