title: Origin of granules in granular cell tumor. Intracellular myelin formation with autodigestion.
abstract: Eight cases of granular cell tumor were stained with Luxol fast blue to look for the presence of myelin. Luxol fast blue-positive granules were present in all cases. One case was studied ultrastructurally. It showed evidence of origin of granules as infoldings of cell membrane by a process similar to myelin formation around axons. These infoldings subsequently appear to be phagocytosed by lysosomes, resulting in the typical granules of the granular cell tumor.
authors.affiliation: Department of Pathology, Bellevue Hospital, New York, NY 10016.
authors.forename: K R
authors.initials: KR
authors.lastname: Mittal
authors.forename: L D
authors.initials: LD
authors.lastname: True
mesh_terms: D000009:Abdominal Muscles / Q000473:pathology; D000008:Abdominal Neoplasms / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology; D002462:Cell Membrane / Q000473:pathology; D003594:Cytoplasmic Granules / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology; D007211:Indoles; D009186:Myelin Sheath / Q000032:analysis*; D009379:Neoplasms, Muscle Tissue / Q000473:pathology* / Q000648:ultrastructure; D010502:Perineum / Q000473:pathology; D010587:Phagocytosis; D013899:Thoracic Neoplasms / Q000473:pathology; D014062:Tongue Neoplasms / Q000473:pathology
chemical_list: D007211:Indoles; C018588:Luxol Fast Blue MBS