title: Effect of Rous associated virus number 7 on lymphoid cells and tissues of the chicken.
abstract: Infection of chicks or chick embryos with Rous associated virus number 7 (RAV-7) led to a decreased blastogenic response to Concanavalin A (Con A) by lymphocytes isolated from the spleen and thymus. Chicks infected with RAV-7 8 days after hatch manifested decreased Con A blastogenesis 5 weeks postinfection, while chicks infected in ovo at 10 days of incubation showed an unusual pattern of cell density dependent decreased blastogenesis two weeks post-hatch (three weeks post-infection). Histopathological examination of tissues from RAV-7 infected chicks revealed evidence of lymphoid organ involution and widespread lymphoproliferative lesions by 3 weeks of age. The combination of decreased in vitro lymphoid blastogenesis and in vivo lymphoproliferation suggests that RAV-7 interacts with lymphocytes in a fashion that has not previously been described in the chicken.
authors.forename: J E
authors.initials: JE
authors.lastname: Heidrich
authors.forename: M A
authors.initials: MA
authors.lastname: Adcock
authors.forename: C
authors.initials: C
authors.lastname: Bolin
authors.forename: N F
authors.initials: NF
authors.lastname: Cheville
authors.forename: R E
authors.initials: RE
authors.lastname: Smith
mesh_terms: D000818:Animals; D001353:Avian Leukosis / Q000276:immunology* / Q000473:pathology; D001354:Avian Leukosis Virus / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology; D002642:Chick Embryo; D002645:Chickens; D003208:Concanavalin A; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D009206:Myocardium / Q000276:immunology / Q000473:pathology; D013154:Spleen / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology
chemical_list: D003208:Concanavalin A