[1-Hexylcarbamoyl-5-fluorouracil (HCFU) effective in hepatocellular carcinoma metastatic to the lungs--a case report].
A 74-year-old female undergoing hepatic resection for hepatocellular carcinoma developed intrahepatic recurrence together with lung metastases 6 months later. At detection of recurrence, she was treated by lipiodolization using 20 mg adriamycin by Seldinger's technic. She was then placed on oral 1-hexylcarbamoyl-5-fluorouracil (HCFU) daily. Three months later, it was found that the numbers and size of metastatic nodules in the lungs had markedly decreased on plain chest X-ray. Hepatic angiogram also showed a decrease in the size and numbers of intrahepatic nodules. Serum concentration of alpha-fetoprotein dropped from 8,200 ng/ml at detection of recurrence to 19.1 ng/ml 9 months after initiation of HCFU therapy. She has been on oral HCFU without any adverse effect and she was well at the time of writing, 19 months and 13 months after surgery and detection of recurrence, respectively.
Higashi
H
H
Dept. of Surgery II, Kyushu University, Faculty of Medicine.
Takenaka
K
K
Kanematsu
T
T
Matsumata
T
T
Yoshida
Y
Y
Sugimachi
K
K
D000284:Administration, Oral; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000556:secondary; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary
D000970:Antineoplastic Agents; C017367:carmofur; D005472:Fluorouracil