Stimulation of non-specific host resistance against Sendai virus and Escherichia coli infections by chitin derivatives in mice.
The efficacy of chitin derivatives on non-specific host resistance to Sendai virus and Escherichia coli infections was studied in mice. Seventy percent deacetylated chitin (DAC-70) and N-trimethylated DAC-70 [DAC-70(Me)3] showed protective activity against Sendai virus infection; however, carboxymethyl-chitin (CM-chitin) did not. DAC-70 also showed protective activity against E. coli infection.
Iida
J
J
Institute of Immunological Science, Hokkaido University, Sapporo, Japan.
Une
T
T
Ishihara
C
C
Nishimura
K
K
Tokura
S
S
Mizukoshi
N
N
Azuma
I
I
D000281:Administration, Intranasal; D000818:Animals; D002686:Chitin / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004927:Escherichia coli Infections / Q000276:immunology*; D007113:Immunity, Innate / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010222:Parainfluenza Virus 1, Human; D018184:Paramyxoviridae Infections / Q000276:immunology*
D002686:Chitin