[Study on the interactions during storage of compounds of the antacid group. I. Interactions of the components in suspensions].
Twenty antacid mixtures of six quality groups containing Al(OH)3, gel, Mg(OH)2, Mg2Si3O8, CaCO3 and NaAl(OH)2CO3 at different ratios were prepared and stored for 150 days at 20 degrees C in the form of aqueous suspensions. Changes of pH in the suspensions were measured, and the accompanying structural changes were examined by IR spectrometry and X-ray diffraction analysis. Hydrotalcite was found to be formed during storage of aqueous suspensions of mixtures of Al(OH)3 Mg(OH)2; Al(OH)3: Mg(OH)2: CaCO3; Al(OH)3: Mg(OH)2: NaAl(OH)2CO3 and Mg(OH)2: NaAl(OH)2CO3. Initial neutralization activities of the suspensions and those found after the storage were compared.
Pawlaczyk
J
J
Lutka
A
A
D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000494:pharmacology*; D000863:Antacids / Q000494:pharmacology*; D002119:Calcium Carbonate / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D004347:Drug Interactions; D004356:Drug Storage; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology*; D008276:Magnesium Hydroxide / Q000008:administration & dosage / Q000494:pharmacology*; D013535:Suspensions
D000863:Antacids; D004338:Drug Combinations; D013535:Suspensions; C010467:hydrotalcite; D000536:Aluminum Hydroxide; D002119:Calcium Carbonate; D008274:Magnesium; D008276:Magnesium Hydroxide
Badanie oddziaływań zachodzacych podczas przechowywania mieszanin z grupy antacida. I. Oddziaływania miedzy składnikami mieszanin w zawiesinie.