Induction of sister-chromatid exchanges in L1210 leukemia cells by new antitumor 2-haloethyl(methylsulfonyl) methanesulfonate compounds.
The antitumor 2-halo(chloro, bromo, and fluoro)-ethyl(methylsulfonyl) methanesulfonates, ethyl(methylsulfonyl) methanesulfonate, and chlorozotocin, a 2-chloroethylnitrosourea, were evaluated for their potential to induce SCEs in L1210 cells. The results indicate that all the compounds induced approximately 2-fold or greater increases in SCEs in a dose-related manner. 2-Chloroethyl(methylsulfonyl) methanesulfonate, a DNA-interacting agent and a drug selected for clinical trials, exhibited the highest SCE increase in these cells.
Siddiqui
K M
KM
Southern Research Institute, Birmingham, AL.
Alexander
J A
JA
Struck
R F
RF
D000477:Alkylating Agents / Q000494:pharmacology; D000818:Animals; D003432:Cross-Linking Reagents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007939:Leukemia L1210 / Q000473:pathology*; D008698:Mesylates / Q000494:pharmacology*; D051379:Mice; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013311:Streptozocin / Q000031:analogs & derivatives* / Q000494:pharmacology; D013450:Sulfones / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000648:ultrastructure
D000477:Alkylating Agents; D003432:Cross-Linking Reagents; D008698:Mesylates; D013450:Sulfones; C007028:chlorozotocin; D013311:Streptozocin