title: Diagnosis, staging, and treatment of juvenile nasopharyngeal angiofibroma (JNA).
abstract: Nineteen patients with juvenile nasopharyngeal angiofibroma (JNA) were surgically treated with different techniques from January 1968 through December 1985. Two patients had undergone a previous operation at another hospital; all patients were males (mean age 15.4), and the most common symptom was nasal obstruction (84.2%). Lateral extension into the pterygomaxillary fossa occurred in 14 patients (73.6%), and 2 also had intracranial invasion (10.5%). In five cases, the tumor's cytosol was analyzed for hormonal receptors. Negative values for estrogen and progesterone receptors were obtained, although the content of dehydrotestosterone receptors was highly positive. These results tend to support the hypothesis of JNA's androgen-dependence. The authors emphasize the need of a preoperative staging classification based on clinicoradiological data in selecting the most adequate surgical approach. Tumors with lateral extension into the pterygomaxillary fossa can be easily removed through a midface degloving; large involvement of the infratemporal fossa requires, also, a transzygomatic dissection. In JNAs with intracranial extension a combined intracranial-extracranial approach is advisable.
authors.affiliation: ENT Clinic, University of Brescia, Italy.
authors.forename: A R
authors.initials: AR
authors.lastname: Antonelli
authors.forename: J
authors.initials: J
authors.lastname: Cappiello
authors.forename: D
authors.initials: D
authors.lastname: Di Lorenzo
authors.forename: C A
authors.initials: CA
authors.lastname: Donajo
authors.forename: P
authors.initials: P
authors.lastname: Nicolai
authors.forename: A
authors.initials: A
authors.lastname: Orlandini
mesh_terms: D000293:Adolescent; D002648:Child; D005500:Follow-Up Studies; D018219:Histiocytoma, Benign Fibrous / Q000032:analysis / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008722:Methods; D009303:Nasopharyngeal Neoplasms / Q000032:analysis / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011956:Receptors, Cell Surface / Q000032:analysis
chemical_list: D011956:Receptors, Cell Surface