Expression of MHC class I genes in mouse hepatitis virus (MHV-A59) infection and in multiple sclerosis.
Our studies revealed that virus induced demyelination as well as human inflammatory demyelination involves upregulation of class I MHC genes and surface expression of antigens encoded by these genes. Induction involves the action of an intermediate soluble factor/s which is at present unknown. These findings suggest that MHC class I restricted, cytotoxic T lymphocyte (CTL) reactions, against self or foreign antigens may play a role in these conditions. These findings may help to elucidate the mechanism of coronavirus-induced demyelination as well as the pathogenesis of multiple sclerosis.
Lavi
E
E
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia.
Suzumura
A
A
Lampson
L A
LA
Siegel
R M
RM
Murasko
D M
DM
Silberberg
D H
DH
Weiss
S R
SR
D000818:Animals; D002478:Cells, Cultured; D003711:Demyelinating Diseases / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation; D006524:Hepatitis, Viral, Animal / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007125:Immunogenetics; D008285:Major Histocompatibility Complex; D051379:Mice; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology; D006517:Murine hepatitis virus; D009457:Neuroglia / Q000276:immunology