[Interleukin-1 and fibrinolysis. In vivo studies].
Distinct decrease in fibrinolytic activity of both whole blood plasma and its euglobulin fraction, occurring due to liberation of an inhibitor of plasminogen activator into circulation, was observed within 2-4 hrs after a single intravenous administration of rabbit interleukin-I into rats at a dose of 50 micrograms/kg, while the activator activity was increased in kidney heart, spleen and lung tissues. The similar data were obtained if the dose was either increased up to 150 micrograms/kg or decreased down to 5 micrograms/kg and 0.5 micrograms/kg, but the effect observed proved to be dose-dependent. Three injections of interleukin-I caused more pronounced increase in concentration of fibrinogen and antiplasmins as compared with controls.
Liutova
L V
LV
Andreenko
G V
GV
Karabasova
M A
MA
Rybakina
E G
EG
Kozinets
I A
IA
Ashmarin
I P
IP
D000818:Animals; D005342:Fibrinolysis / Q000187:drug effects*; D007375:Interleukin-1 / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D015849:Plasminogen Inactivators / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000378:metabolism
D007375:Interleukin-1; D015849:Plasminogen Inactivators
Interleĭkin-1 i fibrinoliz. Issledovaniia v usloviiakh in vivo.