Effect of ACTH4-10 on nerve fiber regeneration after sciatic nerve crush in rabbits: an electrophysiological and morphological study.
Crush of sciatic nerve in rabbits supported by morphologic and electrophysiologic data was used to evaluate the effects of ACTH4-10 on nerve fiber regeneration. Treated animals showed a statistically significant higher regeneration rate than did control rabbits. Fiber density and mean diameters of myelinated nerve fibers were measured in semithin nerve sections at 1 and 3 cm distal from the crushed point at three different time points. Nerve fiber density results were higher in ACTH4-10-than in vehicle-treated rabbits. This difference showed an unequivocal trend and attained a statistically significant level in the sections 3 cm distal from the crush. ACTH4-10 seemed therefore to have a beneficial effect on nerve fiber regeneration.
Girlanda
P
P
Institute of Neurological and Neurosurgical Sciences, University of Messina, Italy.
Muglia
U
U
Vita
G
G
Dattola
R
R
Santoro
M
M
Toscano
A
A
Venuto
C
C
Roberto
M L
ML
Baradello
A
A
Romano
M
M
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D004594:Electrophysiology; D008297:Male; D009409:Nerve Crush; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology*; D009416:Nerve Regeneration / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology*; D011817:Rabbits; D012584:Sciatic Nerve / Q000473:pathology / Q000502:physiology*
D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10)