[Cytotoxicity induced by the serum of patients with AIDS and at high risk of AIDS against cells infected with Epstein-Barr virus].
Serologic reactivity against EBV-infected lines was assayed in patients with AIDS (n = 4) or the AIDS related complex (AIDS-RC) (n = 46) residing in Argentina. Anti-VCA serology was comparable to that of controls. However sera from AIDS and AIDS-RC could induce antibody dependent cell mediated cytotoxicity (ADCC) to EBV-infected cell lines (P3HRIK and Raji). ADCC activity could be recovered in the high molecular weight fractions of AIDS and AIDS-RC sera. ADCC was observed in sera with high levels of PEG precipitable material (PEG-pp) but was unrelated to the presence of complement-fixing immune complexes (Clq-F) or to anti-VCA titers. Fc receptor (FcR) bridging between target cells FcR and effector cells FcR may play a role in the outcome of total ADCC.
De la Barrera
S
S
Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
Fejes
M
M
Riera
N E
NE
Scaglione
C
C
Pérez Blanco
R
R
de Bracco
M M
MM
D000386:AIDS-Related Complex / Q000097:blood / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology; D000920:Antibody-Dependent Cell Cytotoxicity; D000936:Antigen-Antibody Complex / Q000032:analysis; D000956:Antigens, Viral / Q000276:immunology; D002051:Burkitt Lymphoma / Q000473:pathology; D036022:Capsid Proteins; D002460:Cell Line; D003166:Complement Activating Enzymes / Q000032:analysis; D003172:Complement C1 / Q000032:analysis; D015922:Complement C1q; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D008297:Male; D011961:Receptors, Fc / Q000276:immunology; D014407:Tumor Cells, Cultured
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D036022:Capsid Proteins; D003172:Complement C1; C041788:Epstein-Barr viral capsid antigen; D011961:Receptors, Fc; D015922:Complement C1q; D003166:Complement Activating Enzymes
Citotoxicidad inducida por el suero de pacientes con SIDA y alto riesgo de SIDA (SAR) contra células infectadas por el virus de Epstein-Barr.