[New therapeutic aspects in the treatment of diffuse peritonitis].
The diffuse peritonitis is a syndrome during the course of which biochemical reactive chains are activated according to a cascade principle. Most of these biochemical reactive chains develop within an acid environment. The solutions applied for abdominal lavage so far had neutral pH value. The present acute peritonitis experiment has shown that a peritoneal pH increase during lavage therapy stopped the septic reactive chain and thus improved significantly the rate of survival in the test animals. These experimental findings ar now subject for clinical examination.
Imhof
M
M
Chirurgische Universitätsklinik Würzburg.
Schmidt
E
E
Bruch
H P
HP
Oppelt
M
M
Conrad
F
F
Döll
W
W
D000818:Animals; D001639:Bicarbonates / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D010533:Peritoneal Lavage / Q000379:methods*; D010538:Peritonitis / Q000628:therapy*; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic / Q000628:therapy; D012964:Sodium / Q000008:administration & dosage*; D017693:Sodium Bicarbonate; D012965:Sodium Chloride / Q000008:administration & dosage*
D001639:Bicarbonates; D012965:Sodium Chloride; D017693:Sodium Bicarbonate; D012964:Sodium
Neue therapeutische Aspekte in der Behandlung der diffusen Peritonitis.