Mechanisms of parathyroid hormone resistance in pseudohypoparathyroidism.
The problem with PHP is that it is almost certainly a heterogeneous condition encompassing a number of defects within the PTH receptor-adenylate cyclase complex. The clinical manifestations of PTH resistance are amplified and extended by a number of associated abnormalities. These include a low intracellular calcium concentration, secondary hyperparathyroidism, reduced production of 1,25-(OH)2D and perhaps the secretion of an abnormal PTH peptide. Almost every aspect of PTH function seems involved and this makes PHP a fascinating condition in which to test current views of the role of PTH in the integration of the calcium homoeostatic system.
Hosking
D J
DJ
Metabolism/Diabetes, City Hospital, Nottingham, U.K.
Kerr
D
D
D000262:Adenylyl Cyclases / Q000378:metabolism; D006801:Humans; D010281:Parathyroid Hormone / Q000502:physiology*; D011547:Pseudohypoparathyroidism / Q000503:physiopathology*; D011956:Receptors, Cell Surface / Q000378:metabolism; D018016:Receptors, Parathyroid Hormone
D010281:Parathyroid Hormone; D011956:Receptors, Cell Surface; D018016:Receptors, Parathyroid Hormone; D000262:Adenylyl Cyclases