[Effects of isoflurane on intracranial pressure and cerebral blood flow pressure in coma patients at neurologic intensive care units. Apropos of 12 cases].
Twelve comatose patients treated in a neurological intensive care unit have been given oxygen - Isoflurane gas inhalation to study the effect on Intra Cranial Pressure (I.C.P.) while undergoing tracheal suction. Raised I.C.P. decrease while one per cent Isoflurane is given during suction; but when Isoflurane is introduced especially on higher intracerebral pressure patients (greater than 37 kPa-20 mmHg) cerebral perfusion pressure decrease without change in I.C.P. and this result is correlated to blood pressure fall. Cerebral blood flow has not been measured while Isoflurane was given; other similar studies give different results. Considering these results, Isoflurane must be used carefully and cautiously on suspected elevated I.C.P. patients or patients with hypovolemia or hypertension.
Montarry
M
M
Jourdan
C
C
D000293:Adolescent; D000328:Adult; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003128:Coma / Q000503:physiopathology; D003422:Critical Care; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects*; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D011312:Pressure
D007530:Isoflurane
Effet de l'isoflurane sur la pression intracrânienne et la pression de perfusion cérébrale de malades comateux en neuro-réanimation. A propos de douze observations.