[cAMP acceptor protein of Escherichia coli K-12 may be the repressor of the late promoter of bacteriophage lambda].
By computer analysis of the lambda phage DNA putative cAMP-CAP binding site has been found. This site (44506-AcgTGTGAccgcatTCAAAaT-44486) is located 40 bp upstream to the late PR' promoter. The sequence denoted is located on the coding DNA strand, similar to the cAMP-CAP binding sites in all four genes known to be subject to cAMP-CAP repression. It is suggested that cAMP-CAP can serve as a repressor of the phage lambda late promoter PR'. Such repression can arrest the expression of late lambda genes and in this way increase the frequency of lysogenization.
Gol'denberg
D S
DS
D010582:Bacteriophage lambda / Q000235:genetics*; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D004279:DNA, Viral / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D011401:Promoter Regions, Genetic; D039381:RNA Cap-Binding Proteins; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D012689:Sequence Homology, Nucleic Acid; D014157:Transcription Factors / Q000235:genetics*
D002352:Carrier Proteins; D004279:DNA, Viral; D039381:RNA Cap-Binding Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; D000242:Cyclic AMP
Belok-aktseptor tsANF Escherichia coli K-12 mozhet iavliat'sia repressorom pozdnego promotora PR' bakteriofaga lambda.