[The effect of hydroxyprogesterone caproate and its combination with tamoxifen on steroid hormone receptors in the tumor and on the basic parameters of reproductive homeostasis in patients with cancer of the corpus uteri].
Oxyprogesterone capronate (OPC) was administered preoperatively to 46 patients with endometrial tumors and tamoxifen (T) + OPC--to 72 patients. Complex treatment was followed by more pronounced pathomorphosis in tumor. Both schedules inhibited gonadotropin secretion and lowered colpocytoscopic indexes. Dual effect of complex treatment (T + OPC) on the level of cytoplasmic receptors to progesterone was observed. Initially low levels rose while high ones dropped by the end of a 20-day course. Progestin treatment in endometrial carcinoma patients with relatively low estrogen levels should be complemented with tamoxifen to stimulate tumor sensitivity to progestagens.
Vishnevskiĭ
A S
AS
Bokhman
Ia V
IaV
Tsyrlina
E V
EV
Bobrov
Iu F
IuF
Shtofmakher
I A
IA
D000077713:17 alpha-Hydroxyprogesterone Caproate; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D006908:Hydroxyprogesterones / Q000627:therapeutic use*; D008875:Middle Aged; D011300:Preoperative Care; D045167:Progesterone Congeners / Q000627:therapeutic use*; D011959:Receptors, Estradiol / Q000032:analysis / Q000187:drug effects*; D011980:Receptors, Progesterone / Q000032:analysis / Q000187:drug effects*; D012098:Reproduction / Q000187:drug effects*; D013629:Tamoxifen / Q000627:therapeutic use*; D014594:Uterine Neoplasms / Q000032:analysis / Q000188:drug therapy* / Q000503:physiopathology
D006908:Hydroxyprogesterones; D045167:Progesterone Congeners; D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; D013629:Tamoxifen; D000077713:17 alpha-Hydroxyprogesterone Caproate
Vliianie oksiprogesterona kapronata i ego sochetaniia s tamoksifenom na retseptory steroidnykh gormonov v opukholi i osnovnye parametry reproduktivnogo gomeostata u bol'nykh rakom tela matki.