Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides.
Experimental allergic encephalomyelitis (EAE) is an autoimmune disease of the central nervous system mediated by CD4+ T cells reactive with myelin basic protein (MBP). Rats were rendered resistant to the induction of EAE by vaccination with synthetic peptides corresponding to idiotypic determinants of the beta chain VDJ region and J alpha regions of the T cell receptor (TCR) that are conserved among encephalitogenic T cells. These findings demonstrate the utility of TCR peptide vaccination for modulating the activity of autoreactive T cells and represent a general therapeutic approach for T cell-mediated pathogenesis.
Howell
M D
MD
Immune Response Corporation, San Diego, CA 92121.
Winters
S T
ST
Olee
T
T
Powell
H C
HC
Carlo
D J
DJ
Brostoff
S W
SW
D000595:Amino Acid Sequence; D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000517:prevention & control; D007167:Immunotherapy; D046911:Macromolecular Substances; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D010455:Peptides / Q000008:administration & dosage / Q000138:chemical synthesis / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology*; D012689:Sequence Homology, Nucleic Acid; D014611:Vaccination
D046911:Macromolecular Substances; D010455:Peptides; D011948:Receptors, Antigen, T-Cell