Metabolic consequences of feeding a high-carbohydrate, high-fiber diet to diabetic patients with chronic kidney failure.
The aim of this study was to compare the metabolic effects of a high-carbohydrate (CHO), high-fiber diet with only moderate protein restriction with those of a low-CHO, low-fiber diet with a low protein content in six diabetic patients with moderate chronic renal failure. The high-CHO, high-fiber diet induced a significant improvement in blood glucose control, a significant decrease in serum cholesterol, and a significant increase in fecal nitrogen losses. Other variables evaluated were not significantly different between the two diets, except for a significant increase in serum phosphorus during the high-CHO, high-fiber diet. N balance was not significantly different from 0 at the end of either dietary period and was very similar for both diets. The high-CHO, high-fiber diet presents many beneficial metabolic effects in diabetic patients with chronic renal failure.
Parillo
M
M
Institute of Internal Medicine and Metabolic Disease, 2nd Medical School, University of Naples, Italy.
Riccardi
G
G
Pacioni
D
D
Iovine
C
C
Contaldo
F
F
Isernia
C
C
De Marco
F
F
Perrotti
N
N
Rivellese
A
A
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004043:Dietary Fiber / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage; D005243:Feces / Q000032:analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D009584:Nitrogen / Q000032:analysis; D010758:Phosphorus / Q000097:blood; D012709:Serum Albumin / Q000032:analysis
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004043:Dietary Fiber; D004044:Dietary Proteins; D012709:Serum Albumin; D010758:Phosphorus; D002784:Cholesterol; D003404:Creatinine; D009584:Nitrogen