Antiviral effect of lithium chloride.
Studies in human embryo fibroblasts infected with measles or herpes simplex virus showed a reduction in virus yield when cultures were pretreated with 1-10 mM lithium chloride doses. Maximum effect was obtained by a 1 h treatment with 10 mM lithium chloride, preceding viral infection by 19-24 hours. A specific antiviral effect against measles virus was manifest immediately after culture pretreatment. Intermittent treatment with 10 mM lithium chloride of cultures persistently infected with measles or herpes virus obtained from human myeloid K-562 cell line shows a reduction in the extracellular virus yield. In the K-562/herpes virus system, the culture treatment with lithium chloride and acyclovir (10 microM) has an additive inhibitory effect on virus production. The paper is focused on the mechanism of lithium chloride antiviral action and the expediency of lithium therapy in SSPE (subacute sclerosing panencephalitis).
Cernescu
C
C
Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
Popescu
L
L
Constantinescu
S
S
Cernescu
S
S
D002460:Cell Line; D002712:Chlorides / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008094:Lithium / Q000494:pharmacology* / Q000633:toxicity; D018021:Lithium Chloride; D008459:Measles virus / Q000187:drug effects* / Q000502:physiology; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects
D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride