title: Sodium-bicarbonate cotransport occurs in rat kidney cortical membranes but not in rat small intestinal basolateral membranes.
abstract: Basolateral membrane vesicles were isolated from rat kidney cortex and small intestinal enterocytes. Both membrane preparations show ATP-dependent calcium uptake and cytochalasin B-sensitive D-glucose transport. In renal membranes, sodium influx is stimulated by bicarbonate; bicarbonate-dependent sodium flux is membrane-potential-dependent and inhibited by 4,4'-di-isothiocyanato-2, 2'-stilbenedisulphanic acid ('DIDS'). Small intestinal basolateral membranes do not show bicarbonate-dependent sodium fluxes.
authors.affiliation: Department of Physiology, University of Zurich, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Hagenbuch
authors.forename: G
authors.initials: G
authors.lastname: Stange
authors.forename: H
authors.initials: H
authors.lastname: Murer
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001639:Bicarbonates / Q000493:pharmacokinetics*; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism*; D007672:Kidney Cortex / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism / Q000493:pharmacokinetics*; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D000255:Adenosine Triphosphate; D017693:Sodium Bicarbonate; D012964:Sodium; D002118:Calcium