LY146032 compared with penicillin G in experimental aortic valve endocarditis caused by group G streptococci.
Rabbits with group G streptococcal aortic endocarditis received no therapy (controls); repeated doses of procaine penicillin G, 300 mg/kg (body weight) per day, administered intramuscularly; or LY146032, a new peptolide antibiotic, 20 mg/kg per day, administered intravenously. Penicillin G and LY146032 reduced mean intravegetation group G streptococcal densities significantly below those observed in controls at both day 3 and day 6 of therapy. Penicillin G effected a more rapid clearance of intravegetation streptococci than LY146032 by day 3, but not by day 6, of therapy.
Bayer
A S
AS
Department of Medicine, Harbor-UCLA Medical Center, Torrance, California 90509.
Yih
J
J
Hirano
L
L
D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001021:Aortic Valve; D017576:Daptomycin; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D006349:Heart Valve Diseases / Q000188:drug therapy; D010400:Penicillin G / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010455:Peptides / Q000493:pharmacokinetics / Q000627:therapeutic use; D011817:Rabbits; D011897:Random Allocation; D013290:Streptococcal Infections / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D010455:Peptides; D017576:Daptomycin; D010400:Penicillin G