title: Paget's disease, melanocytic neoplasia and hidradenoma papilliferum of the vulva.
abstract: We present a case of invasive melanoma of the vulva with contiguous changes including melanocytic atypia showing, in part, the features of melanocytic dysplasia and, in part, an in situ malignant component and extramammary Paget's disease. A benign hidradenoma papilliferum was also present. We can find no other reported cases of this combination of lesions. The possible histogenesis is discussed and an origin from a common local stem cell is suggested.
authors.affiliation: Department of Histopathology, St George's Hospital Medical School, London, UK.
authors.forename: W A
authors.initials: WA
authors.lastname: Simpson
authors.forename: M
authors.initials: M
authors.lastname: Burke
authors.forename: J
authors.initials: J
authors.lastname: Frappell
authors.forename: M G
authors.initials: MG
authors.lastname: Cook
mesh_terms: D006607:Adenoma, Sweat Gland / Q000150:complications / Q000473:pathology*; D000368:Aged; D005260:Female; D006801:Humans; D008544:Melanocytes / Q000473:pathology*; D008545:Melanoma / Q000150:complications / Q000473:pathology*; D010145:Paget Disease, Extramammary / Q000150:complications / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000150:complications / Q000473:pathology*