title: Direct electron spin resonance evidence for alpha-tocopherol-induced phase separation in model membranes.
abstract: The high resolution (narrow linewidth) amphiphilic spin probe perdeutero di-t-butyl nitroxide (PDDTBN) has been used to investigate the effect of alpha-tocopherol on lecithin liposomes. The electron spin resonance (ESR) results obtained as a function both of alpha-tocopherol concentration and of temperature indicate the presence of two different hydrophobic sites for the spin probe molecules. The presence of two distinct phases, one alpha-tocopherol-poor and the other alpha-tocopherol-rich, is suggested in these phospholipid bilayers.
authors.affiliation: Dipartimento di Fisica dell'Università di Perugia, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Severcan
authors.forename: S
authors.initials: S
authors.lastname: Cannistraro
mesh_terms: D004578:Electron Spin Resonance Spectroscopy; D008051:Lipid Bilayers; D008081:Liposomes; D008567:Membranes, Artificial; D008954:Models, Biological; D010713:Phosphatidylcholines; D014810:Vitamin E
chemical_list: D008051:Lipid Bilayers; D008081:Liposomes; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D014810:Vitamin E