Non-ocular cancer in retinoblastoma survivors.
The risk of non-ocular cancer has been investigated in 150 surviving Danish patients with retinoblastoma diagnosed in the period 1943-1984. None of the patients had been treated with chemotherapeutic drugs. The overall relative risk of non-ocular cancer was 4.2 (95% confidence limits, 1.1-11.5). In the subgroups of hereditary retinoblastoma, the relative risk was 15.4 (95% confidence limits, 2.6-50.8), and in the subgroups of non-hereditary retinoblastoma the relative risk was 1.7 (95% confidence limits (0.1-8.5). The risk of cancer among 267 parents of retinoblastoma children was not different from that of the general population.
Winther
J
J
Department of Ophthalmology, University Hospital Aarhus, Denmark.
Olsen
J H
JH
D005134:Eye Neoplasms / Q000235:genetics / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009378:Neoplasms, Multiple Primary; D010290:Parents; D012175:Retinoblastoma / Q000235:genetics / Q000401:mortality / Q000601:surgery*; D012307:Risk Factors