Kainic acid microinjected into the cat raphe dorsal nucleus modulates the somatosensory evoked potentials and their cycles of excitability.
Studies were made on the effect of the neuroexcitatory agent kainic acid, microinjected into raphe dorsal nucleus by glass micropipette and an air pressure system in doses ranging from 0.2 to 24.0 nmol (in volumes from 0.05 microliter to 0.47 microliter), on the somatosensory evoked potentials and their cycles of recovery (excitability) obtained from cortex (primary somatosensory and parietal associative), thalamus (ventral posterolateral nucleus and centre median nucleus), mesencephalic reticular formation and raphe dorsal nucleus. Kainic acid in doses higher than 3 nmol exerted an activating effect on the evoked potentials and their recovery cycles especially in thalamus and mesencephalic reticular formation. The analysis of these electrophysiological parameters revealed that the non-specific structures were involved to a larger extent in the activating effect of kainic acid than the specific ones. The morphological changes were not severe and were limited to a part of the raphe dorsal nucleus neurons. Our data indicate that kainic acid injected into raphe dorsal nucleus modulates (in direction of facilitation) the somatosensory evoked potentials and their cycles of excitability obtained in some brain structures. The results suggest that this nucleus is involved in the somatosensory information processing in a non-specific manner.
Moyanova
S
S
Dimov
S
S
Ivanova
A
A
D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D011826:Radial Nerve / Q000187:drug effects; D011903:Raphe Nuclei / Q000187:drug effects*; D013003:Somatosensory Cortex / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*
D007608:Kainic Acid