title: Regulation of IgE-dependent antiparasite functions of rat macrophages and platelets by nedocromil sodium.
abstract: The IgE-dependent stimulation of mononuclear phagocytes and blood platelets can be measured by antiparasite cytotoxicity, oxygen-mediated chemiluminescence and, in macrophages, lysosomal enzyme activity. Using these parameters, the present study demonstrated an inhibition by nedocromil sodium of the IgE-mediated triggering of the nonmast cell inflammatory populations in the rat. These observations suggest that nedocromil sodium may be of value in the modulation of IgE-dependent cell activation inducing the release of inflammatory mediators.
authors.affiliation: Centre d'Immunologie et de Biologie Parasitaire, Unité mixte INSERM 167-CNRS 624, Institut Pasteur, Lille, France.
authors.forename: T
authors.initials: T
authors.lastname: Thorel
authors.forename: M
authors.initials: M
authors.lastname: Joseph
authors.forename: H
authors.initials: H
authors.lastname: Vorng
authors.forename: A
authors.initials: A
authors.lastname: Capron
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000276:immunology* / Q000378:metabolism; D002470:Cell Survival; D003602:Cytotoxicity, Immunologic; D005260:Female; D007073:Immunoglobulin E / Q000494:pharmacology*; D008163:Luminescent Measurements; D008247:Lysosomes / Q000201:enzymology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D017835:Nedocromil; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012550:Schistosoma mansoni / Q000187:drug effects*
chemical_list: D011804:Quinolines; D017835:Nedocromil; D007073:Immunoglobulin E