title: Effect of calcium ionophore A23187 and of leukotrienes B4 and C4 on the adherence of human mononuclear leukocytes.
abstract: The adherence changes induced by the ionophore A23187 and by the leukotrienes, respectively, were investigated in 10 healthy persons. The calcium ionophore A23187 in concentrations of 200 nM, 1 microM and 5 microM induced inhibition of mononuclear leukocyte adherence in a concentration-dependent manner, the maximal adherence inhibition being proved with 5 microM ionophore. The leukotrienes did not significantly alter leukocyte adherence in the test system used. The results of this study suggest that the calcium ionophore A23187-induced leukocyte adherence inhibition may serve as a pharmacological model of the leukocyte adherence inhibition phenomenon, thus providing a useful tool for the investigation of the processes associated with some cellular membrane functions.
authors.affiliation: Palacký University, Department of Biochemistry, Olomouc, Czechoslovakia.
authors.forename: M
authors.initials: M
authors.lastname: Mayer
mesh_terms: D000001:Calcimycin / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology*; D007975:Leukotriene B4 / Q000494:pharmacology*; D013189:SRS-A / Q000494:pharmacology*
chemical_list: D013189:SRS-A; D007975:Leukotriene B4; D000001:Calcimycin