Release of a virus coded glycoprotein from herpes simplex virus type 1 infected cells.
HEp-2 cells, which were infected with HSV-1, excrete besides other proteins a soluble glycoprotein (Mr 125,000-130,000) related to the virus protein gC. The excretion of the glycoprotein and the production of extracellular virus particles is reduced to a similar extent when the cells were treated with monensin. Possible consequences of the excretion of soluble viral proteins to a modulation of the immune response are discussed.
Tiedemann
K H
KH
Institut für Klinische und Experimentelle Virologie, Freien Universität Berlin, Germany.
Hampl
H
H
Habermehl
K O
KO
D002478:Cells, Cultured; D006023:Glycoproteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008985:Monensin / Q000494:pharmacology; D018139:Simplexvirus / Q000235:genetics*
D006023:Glycoproteins; D008985:Monensin