Effect of NCO-700, an inhibitor of thiol protease, on reactive oxygen production by chemotactic peptide-stimulated rabbit peripheral granulocytes.
The specific thiol protease inhibitor, NCO-700, which is related to L-trans-epoxysuccinylpeptides, inhibited oxidant production by chemoattractant-stimulated rabbit polymorphonuclear leukocytes. NCO-700 could also scavenge active oxygen generated from sodium hypochlorite-hydrogen peroxide and hypoxanthine-xanthine oxidase systems.
Tawara
K
K
Department of Pharmacology, Akita University School of Medicine, Japan.
Fujisawa
S
S
Nakai
K
K
D000818:Animals; D015853:Cysteine Proteinase Inhibitors; D006098:Granulocytes / Q000187:drug effects / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism; D006997:Hypochlorous Acid / Q000378:metabolism; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism; D008163:Luminescent Measurements; D008297:Male; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood*; D010879:Piperazines / Q000494:pharmacology*; D011817:Rabbits; D013481:Superoxides / Q000097:blood; D014969:Xanthine Oxidase / Q000378:metabolism
D015853:Cysteine Proteinase Inhibitors; D007042:Hypoxanthines; D010879:Piperazines; D013481:Superoxides; D019271:Hypoxanthine; D009240:N-Formylmethionine Leucyl-Phenylalanine; D006997:Hypochlorous Acid; C036798:NCO 700; D006861:Hydrogen Peroxide; D014969:Xanthine Oxidase; D010100:Oxygen