[Human papillomavirus infections of the cervix uteri. I. Pathobiology, epidemiology and relation to cancer pathogenesis].
Infection of the uterine cervix by human papilloma viruses (HPV) is a ubiquitous yet only recently recognized lesion. The morphological findings correlate with early and late gene expression. The pathological events presumably depend upon the HPV type involved and upon environmental and host factors. The recognized risk factors are those described for epithelial dysplasias and carcinomas. The prevalence is unclear: it varies among different population groups and depends upon the investigation methods employed. The natural history of the infection is unknown, although relations between cervical HPV infection and carcinogenesis are evident. Research is handicapped by the lack of suitable animal or in vitro models.
Locher
G W
GW
Abteilung Gynäkopathologie, Universitäts-Frauenklinik, Bern.
Gerber-Huber
S
S
D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics; D011230:Precancerous Conditions / Q000209:etiology*; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000235:genetics / Q000276:immunology* / Q000635:transmission; D002583:Uterine Cervical Neoplasms / Q000209:etiology*; D002575:Uterine Cervicitis / Q000209:etiology*; D014779:Virus Replication
Humane Papillomavirus-Infektionen der Cervix uteri. I. Pathobiologie, Epidemiologie und Beziehungen zur Krebspathogenese.