title: Isolation of human pancreastatin fragment containing the active sequence from a glucagonoma.
abstract: The primary structure of a human pancreastatin-like peptide was determined from a pancreatic glucagonoma. The 28-amino acid peptide was identified using a specific antibody raised against porcine pancreastatin 1-49 and showed a 75% sequence homology with porcine pancreastatin 22-49 and bovine chromogranin A 267-294. Several forms of pancreastatin-like immunoreactivity were found in human endocrine tumors of which the purified peptide was the smallest and contained the active sequence of pancreastatin.
authors.affiliation: Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.
authors.forename: K
authors.initials: K
authors.lastname: Sekiya
authors.forename: M A
authors.initials: MA
authors.lastname: Ghatei
authors.forename: N
authors.initials: N
authors.lastname: Minamino
authors.forename: D
authors.initials: D
authors.lastname: Bretherton-Watt
authors.forename: H
authors.initials: H
authors.lastname: Matsuo
authors.forename: S R
authors.initials: SR
authors.lastname: Bloom
mesh_terms: D007516:Adenoma, Islet Cell / Q000032:analysis*; D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000918:Antibody Specificity; D002417:Cattle; D053379:Chromogranin A; D005260:Female; D005935:Glucagonoma / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D010187:Pancreatic Hormones / Q000032:analysis* / Q000276:immunology; D010190:Pancreatic Neoplasms / Q000032:analysis*; D010446:Peptide Fragments / Q000032:analysis* / Q000276:immunology; D013552:Swine
chemical_list: D000906:Antibodies; D053379:Chromogranin A; D010187:Pancreatic Hormones; D010446:Peptide Fragments; C050836:pancreastatin