The c-myc protein is associated with the nuclear matrix through specific metal interaction.
We have investigated the subnuclear localisation of the protein product of the c-myc oncogene. We show that, although c-myc is not present in the nuclear skeleton or matrix II fraction, it is associated with the nuclear matrix I fraction which is a complex group of proteins implicated in physiological processes within the nucleus. The interaction of the c-myc protein and the matrix I fraction is through a specific metal interaction and presumably, therefore, represents the in vivo location of this protein.
Van Straaten
J P
JP
Medical Research Council Laboratory of Molecular Biology, Cambridge, England.
Rabbitts
T H
TH
D018288:Carcinoma, Small Cell; D002460:Cell Line; D002467:Cell Nucleus / Q000032:analysis*; D003300:Copper / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms; D011485:Protein Binding; D011518:Proto-Oncogene Proteins / Q000032:analysis* / Q000378:metabolism; D011519:Proto-Oncogenes
D011518:Proto-Oncogene Proteins; D003300:Copper