Successful pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: case report.
In this report, the maternal and fetal risks in a patient with paroxysmal nocturnal hemoglobinuria (PNH) were evaluated. A patient with PNH carried a pregnancy to successful delivery, with a healthy male infant, and suffered from postpartum cerebral subcortical thrombosis followed by recovery. An elevated level of serum lactate dehydrogenase isoenzyme (alpha-hydroxybutyrate dehydrogenase) was observed during pregnancy; the level returned to normal by delivery. However, the hemoglobin concentration during pregnancy and post-partum was kept at 8 g/dl. This is the first report of a relation between the onset of hemolysis and pregnancy. The management of pregnancy in such patients is discussed.
Imai
A
A
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
Takagi
H
H
Kawabata
I
I
Sumi
H
H
Shiraki
S
S
Tamaya
T
T
D000328:Adult; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000097:blood / Q000150:complications* / Q000201:enzymology; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000209:etiology; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000201:enzymology / Q000652:urine*; D011256:Pregnancy Outcome; D011644:Puerperal Disorders / Q000209:etiology
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase