Interleukin II increases cyclic GMP levels in immature thymocytes and mitogen-primed T-lymphocytes.
Interleukin II, also called T-cell growth factor, induces proliferation of immature peanut agglutinin positive murine thymocytes (PNA+) and renders them responsive to concanavalin A. It also, as shown by others, provides a second signal to induce phytohemagglutinin-primed mature human T-lymphocytes to enter DNA synthesis. Both actions are associated with early increases (2-60 min) in cellular levels of cyclic 3'5' guanosine monophosphate (cyclic GMP) without change of cyclic 3'5' adenosine monophosphate (cyclic AMP) levels. Cyclic GMP is postulated to represent part of the mechanism by which IL-2 acts.
Hadden
J W
JW
Program of Immunopharmacology, University of South Florida Medical College, Tampa 33612.
Hadden
E M
EM
Coffey
R G
RG
D000818:Animals; D006152:Cyclic GMP / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism*
D007376:Interleukin-2; D006152:Cyclic GMP