title: Expression and modulation of a retrovirus-associated antigen by murine melanoma cells.
abstract: The antigen recognized by the monoclonal antibody MM2-9B6 is specific for melanomas originating in C57BL/6 mice. It is expressed by three melanomas of independent origin and not by normal or fetal tissues, by a wide variety of other nonmelanoma tumors in C57BL/6 mice, or even by melanomas syngeneic to other strains of mice. We have demonstrated that the expression of the relevant antigen is dependent on the replication and budding of a B-tropic ecotropic murine retrovirus. The relationship between the expression of this virus and carcinogenic progression may yield important insights into the cascade of events leading to neoplastic transformation.
authors.affiliation: Department of Surgery, University of Arizona Health Sciences Center, Tucson 85724.
authors.forename: S P
authors.initials: SP
authors.lastname: Leong
authors.forename: J
authors.initials: J
authors.lastname: Muller
authors.forename: R A
authors.initials: RA
authors.lastname: Yetter
authors.forename: E
authors.initials: E
authors.lastname: Gorelik
authors.forename: T
authors.initials: T
authors.lastname: Takami
authors.forename: V J
authors.initials: VJ
authors.lastname: Hearing
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000951:Antigens, Neoplasm / Q000032:analysis*; D000956:Antigens, Viral / Q000032:analysis*; D002471:Cell Transformation, Neoplastic; D008546:Melanoma, Experimental / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D012190:Retroviridae / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000956:Antigens, Viral