title: Porous hydroxyapatite as a bone graft substitute in cranial reconstruction: a histometric study.
abstract: To assess the potential of a porous hydroxyapatite matrix to serve as a bone graft substitute, bilateral 15 X 20 mm craniectomy defects were reconstructed in 17 dogs with blocks of implant and split-rib autografts. Specimens were retrieved at 3, 6, 12, 24, and 48 months, and undecalcified sections were prepared for microscopy and histometry. The implant and graft cross-sectional areas did not change with time, documenting their equivalent ability to maintain cranial contour. Bone ingrowth extended across the implant from one cranial shelf to the other in 15 specimens. Little apparent bone ingrowth was seen in most graft specimens. Two implants and three grafts were nonunited, possibly due to lack of fixation or the orientation of the histology sections. The implant specimens were composed of 39.3 percent hydroxyapatite matrix, 17.2 percent bone ingrowth, and 43.5 percent soft-tissue ingrowth. The graft specimens were composed of 43.7 percent bone and 56.3 percent soft tissue. This study supported the thesis that a porous hydroxyapatite matrix may function in part as a bone graft substitute. The brittle hydroxyapatite matrix undoubtedly became stronger with bone ingrowth, but the degree of cranial protection achieved was not measured in this study. The size of the cranial defect used in this study did not permit estimation of the distance over which bone ingrowth may be reliably expected. There remains a need for greater understanding of the causes of nonunion, the extent of predictable ingrowth depth, and the strength of the resultant implant-bone composite.
authors.affiliation: Division of Plastic Surgery, University of California Medical Center, San Diego 92103.
authors.forename: R E
authors.initials: RE
authors.lastname: Holmes
authors.forename: H K
authors.initials: HK
authors.lastname: Hagler
mesh_terms: D000818:Animals; D004285:Dogs; D017886:Durapatite; D006882:Hydroxyapatites; D019736:Prostheses and Implants; D012272:Ribs / Q000637:transplantation; D012886:Skull / Q000601:surgery* / Q000648:ultrastructure; D013518:Surgery, Plastic; D014945:Wound Healing
chemical_list: D006882:Hydroxyapatites; D017886:Durapatite