title: Surveillance for stage I non-seminomatous germ cell tumours of the testis: the optimal protocol has not yet been defined.
abstract: Forty-six patients with clinical stage I testicular non-seminomatous germ cell tumours were followed up according to a protocol of active surveillance between 1979 and 1987. The median follow-up time was 40+ months. Thirteen patients (28%) relapsed, predominantly in retroperitoneum and/or lung. Ten of these relapses (76%) occurred within 8 months of orchiectomy. Relapses occurred in 7/35 T1 tumours and 5/10 T2 to T4 tumours. No correlation was detected between the histological type and relapse rate. Three late relapses were diagnosed at 23, 29 and 36 months. Eleven of the relapsed patients remain in prolonged complete remission after PVB chemotherapy +/- surgery; one patient, who initially refused treatment at the time of relapse, has died. Another relapsed with predominant elements of rhabdomyosarcoma intermingled with malignant teratoma in a bone metastasis. He had a partial response to PVB chemotherapy but subsequently died. Thirty-four patients (74%) did not undergo lymphography (LG) and had a higher relapse rate (11/34) than those who had LG (2/12); this was not a statistically significant difference in this small series. The policy of active surveillance is not yet the "state of the art" and should be under constant scrutiny with respect to safety and practice.
authors.affiliation: Department of Clinical Oncology, Royal Prince Alfred Hospital, Sydney, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Raghavan
authors.forename: B
authors.initials: B
authors.lastname: Colls
authors.forename: J
authors.initials: J
authors.lastname: Levi
authors.forename: B
authors.initials: B
authors.lastname: Fitzharris
authors.forename: M H
authors.initials: MH
authors.lastname: Tattersall
authors.forename: C
authors.initials: C
authors.lastname: Atkinson
authors.forename: R
authors.initials: R
authors.lastname: Woods
authors.forename: G
authors.initials: G
authors.lastname: Coorey
authors.forename: C
authors.initials: C
authors.lastname: Farrell
authors.forename: R
authors.initials: R
authors.lastname: Wines
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009373:Neoplasms, Germ Cell and Embryonal / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D012074:Remission Induction; D013736:Testicular Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D013997:Time Factors