title: Effects of ginsenosides on release of [3H]norepinephrine from rat vas deferens and portal vein.
abstract: The effects of ginsenosides (G) on the release of [3H]norepinephrine ([ 3H]NE) from the isolated rat vas deferens (RVD) and portal vein (RPV) preloaded with [3H]NE were studied, G (100 micrograms/ml) did not affect the spontaneous or high potassium (H-K+, 60 mmol/L)- and tyramine (Tyr 10 mumol/L)-evoked release of [3H]NE, but obviously blunted the phentolamine (Phe 10 mumol/L)-induced increase in [3H]NE release from RVD and enhanced the isoprenaline (Iso 0.1 mumol/L)-augmented [3H]NE release from RPV evoked by H-K+. It is still not known whether G can bind with adrenoceptors. We infer that G may act as a modulator in sensitizing both presynaptic alpha 2- and beta-receptors.
authors.forename: Q X
authors.initials: QX
authors.lastname: Zhou
authors.forename: C S
authors.initials: CS
authors.lastname: Xue
authors.forename: D N
authors.initials: DN
authors.lastname: Wang
authors.forename: Y J
authors.initials: YJ
authors.lastname: Zhang
authors.forename: L J
authors.initials: LJ
authors.lastname: Gao
authors.forename: M H
authors.initials: MH
authors.lastname: Chen
mesh_terms: D000818:Animals; D036145:Ginsenosides; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology; D011169:Portal Vein / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects; D012503:Saponins / Q000494:pharmacology*; D014439:Tyramine / Q000494:pharmacology; D014649:Vas Deferens / Q000378:metabolism*
chemical_list: D036145:Ginsenosides; D011941:Receptors, Adrenergic; D012503:Saponins; D007545:Isoproterenol; D009638:Norepinephrine; D014439:Tyramine; D010646:Phentolamine