[Formation of serotonin- and GABA-ergic mechanisms of synaptic transmission in the cat neocortex during early ontogenesis].
In acute experiment on 5-20 days kittens, the reactions were studied of neurones in the cortical somatosensory zone to stimulation of the dorsal raphe nucleus (DRN) and application of serotonin, ethanolamine-O-sulphate and bicucullin. The identity is established of the effect of DRN stimulation and serotonin application eliciting inhibition of the background activity and appearance of inhibitory phases in response to sensory stimulation, beginning from the 10-12th day after birth. A suggestion is made about serotoninergic regulation of GABA-ergic interneurones' in young animals. The dynamics of GABA-ergic brain system formation has been studied. Specific sensitivity of neocortical neurones to GABA increased to the end of the second week of life--the period when modulating serotoninergic influences appear.
Raevskiĭ
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D000375:Aging / Q000502:physiology; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002415:Cats; D004558:Electric Stimulation; D009474:Neurons / Q000502:physiology; D011903:Raphe Nuclei / Q000502:physiology; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D013003:Somatosensory Cortex / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D011963:Receptors, GABA-A; D011985:Receptors, Serotonin; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline
Formirovanie serotonin- i GAMKergicheskikh mekhanizmov sinapticheskoĭ peredachi v neokortekse koshki v rannem ontogeneze.