Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2).
Recombinant B cell stimulatory factor 2 (rBSF-2) did not display any detectable level of antiviral activity when using human diploid fibroblasts, DIP-2, FS-4, FS-7, amnion-derived WISH and FL cells with vesicular stomatitis virus (VSV) and Sindbis virus as challenging agents (less than 2.5 X 10(2) IU/mg). Furthermore anti-IFN-beta could not neutralize the immunoglobulin-inducing activity of BSF-2. Moreover anti-BSF-2 could not neutralize the antiviral activity of IFN-beta. The data indicate that BSF-2 is functionally and immunologically not related to IFNs.
Hirano
T
T
Institute for Molecular and Cellular Biology, Osaka University, Japan.
Matsuda
T
T
Hosoi
K
K
Okano
A
A
Matsui
H
H
Kishimoto
T
T
D003429:Cross Reactions; D007370:Interferon Type I / Q000276:immunology; D015850:Interleukin-6; D007378:Interleukins / Q000276:immunology / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D012845:Sindbis Virus / Q000187:drug effects; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects; D014780:Viruses / Q000187:drug effects*
D007370:Interferon Type I; D015850:Interleukin-6; D007378:Interleukins; D011994:Recombinant Proteins