title: Epinephrine-activation of heparin-nonreleasable lipoprotein lipase in 3 skeletal muscle fiber types of the rat.
abstract: Epinephrine was used to activate the heparin non-releasable lipoprotein lipase (LPL) in the 3 skeletal muscle fiber types of the perfused rat hindlimb. Following a 9 min washout of the capillary-bound lipoprotein lipase, the hindquarter of the rat was perfused with a buffer containing 10 nM of epinephrine. Activity of the residual LPL in soleus, red vastus lateralis, and white vastus lateralis muscles increased 75%, 96%, and 102% respectively, following epinephrine perfusion. These results suggest that skeletal muscle LPL is under hormonal control possibly through protein phosphorylation by cyclic AMP dependent protein kinase.
authors.affiliation: Dept. of Physical Education, Indiana University, Bloomington 47405.
authors.forename: W C
authors.initials: WC
authors.lastname: Miller
authors.forename: J
authors.initials: J
authors.lastname: Gorski
authors.forename: L B
authors.initials: LB
authors.lastname: Oscai
authors.forename: W K
authors.initials: WK
authors.lastname: Palmer
mesh_terms: D000818:Animals; D004789:Enzyme Activation; D004837:Epinephrine / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D007700:Kinetics; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000201:enzymology*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006493:Heparin; D008071:Lipoprotein Lipase; D004837:Epinephrine