Inhibition of cAMP phosphodiesterase by some phototherapeutic agents.
The behaviour of cyclic-3',5'-AMP phosphodiesterase has been studied in the presence of psoralen, 8-methoxy-psoralen (8-MOP), 4,5',8-trimethylpsoralen (TMP) (usually used in PUVA therapy), 4,6,4'-trimethylangelicin (TMA) and khellin recently proposed for the same therapeutical use. TMP and TMA exhibit a significant inhibitory effect on cyclic AMP phosphodiesterase; a light inhibition is produced by khellin at rather high concentration.
Bovalini
L
L
Institute of Biological Chemistry, University of Siena, Italy.
Lusini
P
P
Simoni
S
S
Vedaldi
D
D
Andreassi
L
L
Dall'Acqua
F
F
Martelli
P
P
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D011564:Furocoumarins / Q000494:pharmacology*; D007666:Khellin / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D051381:Rats; D013329:Structure-Activity Relationship
D011564:Furocoumarins; D007666:Khellin; D015105:3',5'-Cyclic-AMP Phosphodiesterases