title: [Properties and virus safety of a pasteurized antithrombin III concentrate].
abstract: In the last decade it appeared more than once that blood donations were contaminated by hitherto unknown viruses. Due to this fact, further steps have to be included into the manufacturing procedure of even up to now safe products from human plasma to eliminate potential new risks. A procedure is described which enables the pasteurization of antithrombin III analogous to albumin without major changes in the properties of the molecule. Thus the new product Kybernin HS/P was obtained. The efficacy of the pasteurization step was tested using relevant human pathogenic viruses. The following titers of important viruses could be totally inactivated within the pasteurization time (h) given in brackets HIV: (human immunodeficiency virus) greater than or equal to 10(6.7) (1), CMV (cytomegaly virus) greater than or equal to 10(4.5) (1), HSV (Herpes simplex virus) greater than or equal to 10(6.8) (4), Polio (poliomyelitis virus) greater than or equal to 10(6.9) (4).
authors.affiliation: Forschungslaboratorien der Behringwerke AG, Marburg/Lahn.
authors.forename: H E
authors.initials: HE
authors.lastname: Karges
authors.forename: P
authors.initials: P
authors.lastname: Fuhge
authors.forename: N
authors.initials: N
authors.lastname: Heimburger
mesh_terms: D000990:Antithrombin III / Q000032:analysis*; D001803:Blood Transfusion; D002846:Chromatography, Affinity; D004340:Drug Contamination; D004591:Electrophoresis, Polyacrylamide Gel; D006678:HIV / Q000302:isolation & purification; D006801:Humans; D017955:Poliovirus / Q000302:isolation & purification; D018139:Simplexvirus / Q000302:isolation & purification; D013242:Sterilization
chemical_list: D000990:Antithrombin III
vernacular_title: Eigenschaften und Virussicherheit eines pasteurisierten Antithrombin III-Konzentrates.