[Effect of neutral muscle proteases on parameters of the contraction of isolated myocardial strips from albino rats during overload and during the period of readaptation].
The treatment of an isolated myocardial strip with Ca2+-activated neutral muscle proteases reduced the contraction amplitude and the relaxation rate of the myocardium by 21.0 +/- 1.7% and 25.0 +/- 1.6%, respectively, and the tension development rate--by 13.0 +/- 1.0%. In the animals exposed to +5 Gz (for 25 min daily during 15 days) the inhibitory effect of neutral proteases on the contractile function of an isolated myocardial strip increased from 23.0 +/- 1.7% to 34.0 +/- 4.3%. The initial sensitivity of the contraction apparatus to proteases did not return to the baseline after 30 days of readaptation.
Barinian
S B
SB
Oganesian
S S
SS
Eloian
M A
MA
D000222:Adaptation, Physiological; D000818:Animals; D002154:Calpain / Q000494:pharmacology*; D003470:Culture Media; D066298:In Vitro Techniques; D008297:Male; D009132:Muscles / Q000201:enzymology*; D009200:Myocardial Contraction; D051381:Rats; D011919:Rats, Inbred Strains; D012399:Rotation; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
D003470:Culture Media; D002154:Calpain
Deĭstvie neitral'nykh myshechnykh proteaz na parametry sokrashcheniia izolirovannoĭ poloski miokarda belykh krys pri peregruzkei v period readaptatsii.