title: The effect of long-term variation in sympathetic activity on testicular morphology in immature rats.
abstract: In order to investigate the effect of increased and decreased sympathetic activity on testicular development, immature male rats were injected with isoproterenol or 6-hydroxydopamine from birth up to 49 days of age. Isoproterenol treatment resulted in a marked Leydig cell hypertrophy but the development of the spermatogenic epithelium was unaffected compared to that in saline treated controls. 6-hydroxydopamine treatment in a dose inhibiting the development of the parotid gland did not influence testicular development.
authors.affiliation: Department of Pathology, University of Umeå, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Bergh
authors.forename: H
authors.initials: H
authors.lastname: Blom
authors.forename: J E
authors.initials: JE
authors.lastname: Damber
authors.forename: R
authors.initials: R
authors.lastname: Henriksson
mesh_terms: D000818:Animals; D006892:Hydroxydopamines / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology*; D007985:Leydig Cells / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects*
chemical_list: D006892:Hydroxydopamines; D011943:Receptors, Adrenergic, beta; D016627:Oxidopamine; D007545:Isoproterenol