Lentivirus infection augments concurrent antigen-induced arthritis.
Experimental antigen-induced arthritis was compared in normal goats and goats infected with caprine arthritis-encephalitis virus. Although acute arthritis was the same in infected and uninfected animals, the disease lasted 16 weeks longer in the caprine arthritis-encephalitis virus-infected goats. Our findings suggest that the arthritis caused by this virus is due to events other than, or in addition to, the immune reaction to viral antigens.
Banks
K L
KL
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.
Jacobs
C A
CA
Michaels
F H
FH
Cheevers
W P
WP
D000208:Acute Disease; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001168:Arthritis / Q000662:veterinary*; D001169:Arthritis, Experimental / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D001170:Arthritis, Infectious / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D002350:Carpus, Animal / Q000473:pathology; D006041:Goats; D012190:Retroviridae / Q000276:immunology / Q000302:isolation & purification; D012192:Retroviridae Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D013582:Synovial Fluid / Q000276:immunology / Q000382:microbiology; D013997:Time Factors
D000914:Antibodies, Viral