Kallikrein-like esteroprotease activity and kininase activity in submandibular gland from a mutant mouse with human cystic fibrosis like alterations.
The submandibular gland of cri/cri and control mice were compared for their activity of glandular kallikrein like esteroprotease and kininase. Esteroprotease activity is significantly reduced in cri/cri mice with respect to control, with an increased kininase activity in cri/cri mice. Since previous work showed an electrolyte abnormality in the salivary glands of this mutant mouse (1) a possible relationship between this alteration with the low activity of cellular esteroprotease and the high kininase activity is suggested.
Dodera Martínez
G
G
Facultad de Farmacia y Bioquímica (Dpto. Ciencias Biológicas-Cátedra de Anatomía y Fisiología Animal), Buenos Aires, Argentina.
Vila
S B
SB
Catanzaro
O L
OL
Pivetta
O H
OH
D000818:Animals; D003550:Cystic Fibrosis / Q000201:enzymology*; D005260:Female; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008817:Mice, Mutant Strains; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000378:metabolism*; D012727:Sex Characteristics; D013363:Submandibular Gland / Q000201:enzymology*
D007703:Peptidyl-Dipeptidase A; D012697:Serine Endopeptidases