title: [Endocrine complications caused by cranial irradiation].
abstract: Cranial irradiation has become one of the leading causes of growth hormone (GH) deficiency. The risk and time of onset of GH deficiency depend mainly on the dose delivered to the hypothalamo-pituitary region: GH deficiency is infrequent after doses under 20 grays and nearly constant after doses above 45 grays. For a given dose, a younger age at the time of irradiation and administration of the dose over a shorter time period increase the risk of GH deficiency. GH secretion can be adequately evaluated using rapid stimulation tests and is usually well correlated with growth, except in patients with radiation-induced precocious puberty or growth delay due to radiation-induced cartilage lesions.
authors.forename: R
authors.initials: R
authors.lastname: Brauner
authors.forename: R
authors.initials: R
authors.lastname: Rappaport
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004702:Endocrine Glands / Q000528:radiation effects*; D006130:Growth Disorders / Q000188:drug therapy / Q000209:etiology*; D013006:Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000528:radiation effects*; D007223:Infant; D007231:Infant, Newborn; D009369:Neoplasms / Q000532:radiotherapy; D011878:Radiotherapy / Q000009:adverse effects*
chemical_list: D013006:Growth Hormone
vernacular_title: Complications endocriniennes de l'irradiation crânienne.