title: [Treatment of arterial occlusions of the lower extremities using 2-stage local application of urokinase].
abstract: We report the results of a 2-phase urokinase protocol for treatment of 28 arterial occlusions of the lower extremities. 26 patients, aged 43-86, with up to 6 weeks old occlusions were treated. In Phase I (average duration 2.7 h) the urokinase solution was injected in intervals directly into the occlusion-material via a F-5 catheter (120,000 U/h). In the following phase II (average duration 26.1 h) 100,000 U/h were given as a continuous arterial infusion and a full heparin regimen was started. In 86% of the treatments there was an improvement as shown by angiography. 75% of the patients could be released from the hospital without a further surgical revascularisation. Alterations of the systemic coagulation-system and bleeding-complications at the puncture site must be expected.
authors.affiliation: Radiologisches Institut der Universität zu Köln.
authors.forename: W
authors.initials: W
authors.lastname: Gross-Fengels
authors.forename: K F
authors.initials: KF
authors.lastname: Neufang
authors.forename: E
authors.initials: E
authors.lastname: Lechler
authors.forename: T
authors.initials: T
authors.lastname: Schmitz-Rixen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D007269:Injections, Intra-Arterial; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014568:Urokinase-Type Plasminogen Activator
vernacular_title: Behandlung arterieller Verschlüsse der unteren Extremität mit lokaler 2stufiger Urokinaseapplikation.