Chemotherapy influencing the course of nephrotic syndrome in colonic carcinoma.
A 50-year-old man presented with the Nephrotic Syndrome (NS). Subsequent investigations showed this to be due to a membranous glomerulonephritis. He was found to have a primary colonic carcinoma with extensive intra-abdominal spread. He was treated with 5-fluorouracil (5FU) with excellent resolution of the NS for a period of 6 months. The disease eventually progressed and the NS recurred on cessation of chemotherapy. This is the first report of such a response to 5FU of which we are aware and emphasizes the usefulness of palliative chemotherapy even in 'resistant' solid tumors when they are complicated by the NS.
Goldstein
D
D
Department of Medical Oncology, St. Vincent's Hospital, Madison, WI.
Kelly
R
R
Ralston
M
M
Penny
R
R
Hayes
J
J
D002288:Adenocarcinoma, Mucinous / Q000150:complications*; D001706:Biopsy; D003110:Colonic Neoplasms / Q000150:complications*; D005472:Fluorouracil / Q000627:therapeutic use*; D005921:Glomerulonephritis / Q000150:complications; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000209:etiology
D005472:Fluorouracil