title: Superoxide-induced deimination of arginine in hematopoietic cells.
abstract: Murine bone marrow cells can produce citrulline directly from L-arginine without intermediate ornithine. An L-arginine-dependent biochemical pathway synthesizing L-citrulline and nitrate, coupled to an effector mechanism has also been recently demonstrated in murine cytotoxic activated macrophages. We show herein that L-citrulline synthesis in murine bone marrow cells can be induced by the generation of superoxide. It can take place in an arginine-free medium, suggesting the implication of a superoxide-dependent peptidyl arginine deiminase.
authors.affiliation: Laboratoire de Biochimie Génétique, Hôpital Necker-Enfants Malades, Paris, France.
authors.forename: P P
authors.initials: PP
authors.lastname: Kamoun
authors.forename: E
authors.initials: E
authors.lastname: Schneider
authors.forename: M
authors.initials: M
authors.lastname: Dy
mesh_terms: D000818:Animals; D001120:Arginine / Q000378:metabolism*; D001853:Bone Marrow / Q000378:metabolism; D002956:Citrulline / Q000096:biosynthesis; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D007097:Imines; D051379:Mice; D013481:Superoxides / Q000378:metabolism*
chemical_list: D007097:Imines; D013481:Superoxides; D002956:Citrulline; D001120:Arginine