Effect of combined therapy in patients with urolithiasis of lower urinary pH.
The effect of combining therapy with hydrochlorothiazide, allopurinol and systemic alkalization for urolithiasis with lower urinary pH was examined. A total of 90 patients were followed up for 1 to 3 years, the average follow up period being 18 months. The total stone disappearance rate was 60% (kidney stone), 74% (ureter stone) and 20% (bladder stone). Large amounts of thiazide diuretics, potassium and magnesium were intravenously administered to a patient with systemic alkalization at slow infusion speed, neither serious side effects nor complication occurred. This method is simple and an effective remedy. It is also very practical in the developing countries of the third world.
Wei
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Department of Urology, Hyogo College of Medicine.
D000328:Adult; D000368:Aged; D000493:Allopurinol / Q000008:administration & dosage; D001639:Bicarbonates / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000008:administration & dosage; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000008:administration & dosage; D017693:Sodium Bicarbonate; D014545:Urinary Calculi / Q000188:drug therapy* / Q000517:prevention & control / Q000652:urine
D001639:Bicarbonates; D007773:Lactates; D006852:Hydrochlorothiazide; D019344:Lactic Acid; D000493:Allopurinol; D017693:Sodium Bicarbonate; D012964:Sodium