title: Dendritic cells from human tissues express receptors for the immunoregulatory vitamin D3 metabolite, dihydroxycholecalciferol.
abstract: Dendritic cells have been isolated from human tonsillar tissue and shown to act as accessory cells in a mitogenic response. The dendritic cells will induced receptors for the active metabolite of vitamin D3, 1,25(OH)2D3, in the responder E+ T cells. The dendritic cells themselves constitutively express receptors for the metabolite, and this distinguishes them from other non-T cells in lymphomedullary tissue. Expression of the 1,25(OH)2D3 receptor may be a dendritic cell property that facilitates their accessory cell role within the tissue microenvironment.
authors.affiliation: Bland-Sutton Institute of Pathology, University College and Middlesex School of Medicine, London, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Brennan
authors.forename: D R
authors.initials: DR
authors.lastname: Katz
authors.forename: J D
authors.initials: JD
authors.lastname: Nunn
authors.forename: S
authors.initials: S
authors.lastname: Barker
authors.forename: M
authors.initials: M
authors.lastname: Hewison
authors.forename: L J
authors.initials: LJ
authors.lastname: Fraher
authors.forename: J L
authors.initials: JL
authors.lastname: O'Riordan
mesh_terms: D002117:Calcitriol / Q000494:pharmacology; D002455:Cell Division; D003208:Concanavalin A / Q000494:pharmacology; D003713:Dendritic Cells / Q000032:analysis*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D014066:Palatine Tonsil / Q000276:immunology; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid / Q000032:analysis*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
chemical_list: D018167:Receptors, Calcitriol; D011987:Receptors, Steroid; D003208:Concanavalin A; D002117:Calcitriol