Expression of c-myc in canine mammary tumours.
The expression of the protooncogene c-myc was examined in twelve canine mammary tumours of different histological type. Only in one tumour--a poorly differentiated carcinoma--was the amount of RNA that hybridized with our cDNA probe for the myc gene significantly increased. Restriction fragment length analysis of genomic DNA from this tumour did not reveal any amplification or other rearrangements in this gene locus.
Engström
W
W
Department of Tumour Pathology, Karolinska Hospital, Stockholm, Sweden.
Barrios
C
C
Azawedo
E
E
Möllermark
G
G
Kängström
L E
LE
Eliason
I
I
Larsson
O
O
D000818:Animals; D001345:Autoradiography; D004262:DNA Restriction Enzymes; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005260:Female; D005784:Gene Amplification; D005786:Gene Expression Regulation; D008321:Mammary Glands, Animal; D009369:Neoplasms / Q000235:genetics* / Q000662:veterinary; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D012334:RNA, Neoplasm / Q000032:analysis
D012334:RNA, Neoplasm; D004262:DNA Restriction Enzymes