title: [Neurologic effects of acyclovir after an allogenic marrow graft].
abstract: On the 4th day of acyclovir treatment for Herpes simplex pneumonia, a 28 month-old girl who had received allogenic marrow transplant for stage IV neuroblastoma presented with severe neurologic disorders including coma and choreic movements. These symptoms disappeared 9 days after acyclovir was stopped. The disturbance in acyclovir kinetics because of acute renal failure and/or a cerebral cortex atrophy might explain the poor neurologic tolerance of acyclovir. This reversible neurologic involvement on a prone patient should be known as a differential diagnosis of Herpes simplex encephalitis.
authors.affiliation: Service de Réanimation Infantile Polyvalente et Prématurés, CHU, Besançon.
authors.forename: A
authors.initials: A
authors.lastname: Burguet
authors.forename: A
authors.initials: A
authors.lastname: Menget
authors.forename: C
authors.initials: C
authors.lastname: Fromentin
authors.forename: E
authors.initials: E
authors.lastname: Plouvier
authors.forename: D
authors.initials: D
authors.lastname: Amsallem
authors.forename: A
authors.initials: A
authors.lastname: Noir
authors.forename: F
authors.initials: F
authors.lastname: Lokiec
mesh_terms: D000212:Acyclovir / Q000009:adverse effects*; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D002819:Chorea / Q000139:chemically induced*; D003128:Coma / Q000139:chemically induced*; D006566:Herpesviridae Infections / Q000188:drug therapy; D006801:Humans; D011183:Postoperative Complications; D014184:Transplantation, Homologous
chemical_list: D000212:Acyclovir
vernacular_title: Effets neurologiques de l'aciclovir après greffe de moelle allogénique.