Hepatocellular carcinoma among HBsAg positive blood donors in Fukuoka, Japan.
In order to examine the association between hepatitis B virus carriage and hepatocellular carcinoma, 3765 HBsAg positive blood donors were followed from 1977 to 1983 in Fukuoka, Japan. The observed number of deaths was compared with the expected deaths calculated by applying cause-, sex- and age-specific death rates for Fukuoka in 1980 to sex- and age-specific population at risk of the subjects. Among 2595 male blood donors, mortality from liver cancer (or hepatocellular carcinoma) was specifically elevated compared with the general population, where the observed, expected deaths and O/E were 15, 2.07 and 7.25, respectively (P less than 0.001). This relative risk was assumed to be underestimated partly because of a healthy donor effect. Neither the HBsAg titer nor the HBeAg-Ab system was related to the risk. Relative risk and population attributable risk % in Japan and various countries were estimated.
Tokudome
S
S
Department of Community Health Science, Saga Medical School, Japan.
Ikeda
M
M
Matsushita
K
K
Maeda
Y
Y
Yoshinari
M
M
D001782:Blood Donors; D006528:Carcinoma, Hepatocellular / Q000276:immunology* / Q000401:mortality; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D007564:Japan; D008113:Liver Neoplasms / Q000276:immunology* / Q000401:mortality; D008297:Male
D006514:Hepatitis B Surface Antigens