The influence of 2-acetoxy-1, 3-di(nitroimidazolyl)propane derivatives on human red blood cell membrane ATP-ase activity.
The effect of two nitroimidazoles, 2-acetoxyl-1,3-bis-(2'-methyl-4'-nitro-1'-imidazolyl)propane (Rs-029) and 2-acetoxy-1-(2'-methyl-4'-nitro-1'-imidazolyl)-3-(2''-methyl-5''-nitro- 1- nitroimidazolyl)propane (Rs-034) on ATP level and erythrocyte membrane ATP-ase activity was studied. The action of these compounds on erythrocyte membrane ATP-ase activity differed depending on the structure of nitroimidazoles. Only Rs-029 significantly inhibited (Na+K+) ATP-ase activity and activated Mg2+ ATP-ase. Both, Rs-029 and Rs-034 decreased ATP content in red blood cells after three hours incubation in the presence of plasma.
Rybczyńska
M
M
Department of Biochemistry, Academy of Medicine, Poznań, Poland.
Philips
H
H
Chmiel
J
J
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors* / Q000097:blood; D000255:Adenosine Triphosphate / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000201:enzymology*; D006801:Humans; D066298:In Vitro Techniques; D009593:Nitroimidazoles / Q000633:toxicity; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D001798:Blood Proteins; D009593:Nitroimidazoles; C053928:RS 034; C053927:RS 029; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; D000254:Sodium-Potassium-Exchanging ATPase