title: Na-pump activity in rat kidney cortex cells and its relationship with the cell volume.
abstract: The present work was undertaken to evaluate whether changes in cell water content of rat kidney cortex cells can modulate the transport activity of the ouabain-insensitive Na pump as they modulate the ouabain-insensitive Na+-ATPase. It was found that there is a close relationship between the cell volume and activity of the Na pump, whereas Na,K-pump activity is not affected by variations in cell volume. When the cell water content is low, Na-pump activity (Na+ transport and Na+-ATPase activity) is minimal. Increases in cell water content produce a concomitant increase in Na-pump activity.
authors.affiliation: Centro de Biofisica y Bioquímica, Instituto Venezolano de Investigáciones Científicas, Caracas.
authors.forename: F
authors.initials: F
authors.lastname: Proverbio
authors.forename: T
authors.initials: T
authors.lastname: Proverbio
authors.forename: R G
authors.initials: RG
authors.lastname: Matteo
authors.forename: T M
authors.initials: TM
authors.lastname: Perrone
authors.forename: R
authors.initials: R
authors.lastname: Marín
mesh_terms: D000251:Adenosine Triphosphatases / Q000502:physiology*; D000818:Animals; D001693:Biological Transport, Active; D027682:Cation Transport Proteins; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000502:physiology*; D008297:Male; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology*; D014882:Water-Electrolyte Balance
chemical_list: D027682:Cation Transport Proteins; D012964:Sodium; D000251:Adenosine Triphosphatases; C021838:sodium-translocating ATPase; D000254:Sodium-Potassium-Exchanging ATPase