The signal transducing system coupled to serotonin-S2 receptors.
The signal transducing system coupled to the serotonin-S2 receptor on platelets involves metabolism of inositol-containing phospholipid, elevation of intracellular free Ca2+ and activation of protein kinase C. Evidence for coupling of the serotonin-S2 receptor to the same signal transducing system in brain and smooth muscle tissue is reviewed.
de Chaffoy de Courcelles
D
D
Department of Biochemistry, Janssen Pharmaceutica Research Laboratories, Beerse, Belgium.
Leysen
J E
JE
de Clerck
F
F
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism / Q000502:physiology; D001921:Brain / Q000378:metabolism / Q000502:physiology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism / Q000502:physiology*
D010716:Phosphatidylinositols; D011985:Receptors, Serotonin