title: [The possibility of using outbred mice for the production of monoclonal antibodies].
abstract: Outbred laboratory mice, pretreated with an ascites-forming stimulator and an irradiation dose of 6 Gy, can be used for the production of monoclonal antibodies. However, the passage of hybridomas in irradiated outbred mice rapidly leads to the death of the cells. The properties of antibodies obtained from ascitic fluid of outbred mice are no different from those of antibodies obtained from BALB/c mice.
authors.forename: V V
authors.initials: VV
authors.lastname: Novikov
authors.forename: M N
authors.initials: MN
authors.lastname: Trofimova
authors.forename: I V
authors.initials: IV
authors.lastname: Dubinkin
authors.forename: O B
authors.initials: OB
authors.lastname: Komarova
authors.forename: L Z
authors.initials: LZ
authors.lastname: Biriukova
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification; D001202:Ascitic Fluid / Q000276:immunology; D004307:Dose-Response Relationship, Radiation; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006825:Hybridomas / Q000276:immunology / Q000528:radiation effects / Q000637:transplantation; D051379:Mice / Q000276:immunology*; D008807:Mice, Inbred BALB C
chemical_list: D000911:Antibodies, Monoclonal; D005620:Freund's Adjuvant
vernacular_title: Vozmozhnost' ispol'zovaniia besporodnykh mysheĭ dlia polucheniia monoklonal'nykh antitel.