title: [ATP-dependent transport of calcium in the myocardial sarcoplasmic reticulum during adaptation to muscular activities].
abstract: Two-fold increase in Ca2+-transport properties of Ca2+-pump was detected in myocardial sarcoplasmic reticulum (SR) during adaptation of animals to muscular activity (training by means of running on treadmill within 6 weeks, with gradual increase in duration and intensity). Besides, the rate of SR membranes phosphorylation via cAMP-dependent protein kinase was increased 1.3-fold. At the same time, cAMP-dependent phosphorylation accelerated 1.4-1.5-fold the rate of ATP-dependent transport of Ca2+ in myocardial SR of both control and trained animals. The data obtained suggest that increase in the Ca2+-pump activity and in the rate of phosphorylation of SR membranes via cAMP-dependent protein kinase are of importance for adaptation of animal heart muscle to elevated activity.
authors.forename: M I
authors.initials: MI
authors.lastname: Kalinskiĭ
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Gubskiĭ
authors.forename: N D
authors.initials: ND
authors.lastname: Rudnitskaia
authors.forename: M D
authors.initials: MD
authors.lastname: Kurskiĭ
mesh_terms: D000222:Adaptation, Physiological; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010766:Phosphorylation; D005082:Physical Exertion; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*
chemical_list: D000255:Adenosine Triphosphate; D011493:Protein Kinase C; D002118:Calcium
vernacular_title: ATP-zavisimyĭ transport kal'tsiia v sarkoplazmaticheskom retikulume miokarda pri adaptatsii k myshechnoĭ deiatel'nosti.