Identification of a third form of protein phosphatase 1 in rabbit skeletal muscle that is associated with myosin.
A third form of protein phosphatase 1 has been identified in skeletal muscle which is distinct from the species composed of the catalytic subunit complexed to the glycogen-binding subunit (protein phosphatase 1G) or inhibitor-2 (protein phosphatase 1I). The third form has an apparent molecular mass of 110 kDa, is not immunoprecipitated by antibody prepared against the glycogen-binding subunit, does not interact with glycogen and is devoid of inhibitor-2. It is tightly bound to myosin and is therefore termed protein phosphatase 1M.
Chisholm
A A
AA
Department of Biochemistry, University of Dundee, U.K.
Cohen
P
P
D000818:Animals; D002352:Carrier Proteins; D002850:Chromatography, Gel; D047908:Intracellular Signaling Peptides and Proteins; D009132:Muscles / Q000201:enzymology*; D009210:Myofibrils / Q000201:enzymology; D009218:Myosins / Q000378:metabolism*; D010749:Phosphoprotein Phosphatases / Q000032:analysis* / Q000378:metabolism; D010764:Phosphorylase Kinase / Q000378:metabolism; D054645:Protein Phosphatase 1; D011506:Proteins / Q000494:pharmacology; D011817:Rabbits; D000097847:Protein Phosphatase Inhibitory Proteins
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009218:Myosins; D010749:Phosphoprotein Phosphatases; D010764:Phosphorylase Kinase; D054645:Protein Phosphatase 1; D011506:Proteins; C021042:protein phosphatase inhibitor-1; C024833:protein phosphatase inhibitor-2; D000097847:Protein Phosphatase Inhibitory Proteins