Linkage between phencyclidine (PCP) and N-methyl-D-aspartate (NMDA) receptors in the cerebellum.
It has been suggested that phencyclidine (PCP) receptors may not be linked with N-methyl-D-aspartate (NMDA) receptors in all brain areas. We found that NMDA enhanced [3H]TCP (a PCP analog) binding in extensively washed cortical, but not cerebellar membranes. However, PCP potently inhibited NMDA-induced [3H]norepinephrine release from cerebellar slices in a concentration-dependent manner, suggesting that a subtype of cerebellar PCP receptors is functionally linked with NMDA receptors. It is suggested that this subtype cannot be demonstrated by [3H]TCP binding because of the predominance of low affinity PCP receptors in the cerebellum.
Yi
S J
SJ
Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston 77550.
Snell
L D
LD
Johnson
K M
KM
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D016202:N-Methylaspartate; D009638:Norepinephrine / Q000378:metabolism; D010622:Phencyclidine / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D017478:Receptors, Phencyclidine
D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D017478:Receptors, Phencyclidine; D001224:Aspartic Acid; D016202:N-Methylaspartate; D010622:Phencyclidine; D009638:Norepinephrine