Prevalence of genital HPV infections in a regularly screened population in The Netherlands in relation to cervical cytology.
To determine the prevalence of human papilloma virus (HPV) genotypes in relation to cervical cytology, 1,290 cervical samples from a regularly screened population of 30-55-year-old women were investigated. Gynaecological specimens, obtained from the cervix, were cytologically classified and screened for the presence of HPVs 6/11 and 16/18 using dot-spot DNA hybridisation. Of the cervical samples containing unequivocally normal cells, 21 of 1,271 (1.6%) were found positive for HPV, and of the cervical samples containing cells with mild dysplasia, 6 of 14 (43%) were found positive for HPV. All five samples containing cells consistent with severe dysplasia or carcinoma in situ were found positive for HPV. Approximately 50% of the HPV-positive samples contained HPV 16 and/or HPV 18 DNA.
Melchers
W J
WJ
Department of Pathology, Stichting Samenwerkende Delftse Ziekenhuizen, Delft, The Netherlands.
Herbrink
P
P
Quint
W G
WG
Walboomers
J M
JM
Meijer
C J
CJ
Lindeman
J
J
D000328:Adult; D002278:Carcinoma in Situ / Q000150:complications / Q000382:microbiology / Q000473:pathology; D002584:Cervix Uteri / Q000382:microbiology* / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009426:Netherlands; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000302:isolation & purification*; D014412:Tumor Virus Infections / Q000150:complications* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000382:microbiology / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000382:microbiology / Q000473:pathology
D004279:DNA, Viral