Isoenzymes of alkaline and acid phosphatases as bones metastasis marker in breast cancer patients.
Bone alkaline phosphatase (B-ALP) and tartrate resistant acid phosphatase (TR-ACP) are markers of osteoblastic and osteoclastic activities respectively. During a period of up to two years, these isoenzymes have been assayed in the sera of 191 breast cancer patients; 80 had bone metastases (BM). In BM bearing patients, B-ALP activity was 261 IU/l and 63 IU/l for patients without BM; TR-ACP was respectively 6.6 and 3.3 IU/l. Specificity and sensitivity were calculated according to several criteria. These isoenzyme serum levels were well correlated with those of two breast cancer markers (CEA and CA15.3) and radiograph.
Desoize
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Institut Jean Godinot Reims, France.
Veiler
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V
Pourny
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C
Comoe
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Jardillier
J C
JC
D000135:Acid Phosphatase / Q000097:blood*; D000469:Alkaline Phosphatase / Q000097:blood*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D014408:Biomarkers, Tumor / Q000097:blood*; D001859:Bone Neoplasms / Q000175:diagnosis / Q000201:enzymology / Q000556:secondary*; D001842:Bone and Bones / Q000201:enzymology*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000201:enzymology; D002272:Carcinoembryonic Antigen / Q000032:analysis; D004796:Clinical Enzyme Tests; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007527:Isoenzymes / Q000097:blood*
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D007527:Isoenzymes; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase