Unusual features of CpG-rich (HTF) islands in the human alpha globin complex: association with non-functional pseudogenes and presence within the 3' portion of the zeta gene.
We have characterised a cluster of CpG rich (HTF) islands in the alpha-globin complex and report here two unusual features: The human embryonic zeta 2-globin gene is associated with an HTF island within its 3' portion rather than at the 5' end. Furthermore at least two non-functional pseudogenes within the cluster (psi zeta 1 and psi alpha 2) are associated with CpG rich islands.
Fischel-Ghodsian
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Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
Nicholls
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RD
Higgs
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DR
D000818:Animals; D001483:Base Sequence; D003568:Cytidine Monophosphate / Q000031:analogs & derivatives; D003596:Cytosine; D004262:DNA Restriction Enzymes; D015226:Dinucleoside Phosphates; D005796:Genes; D005914:Globins / Q000235:genetics*; D006147:Guanine; D006151:Guanosine / Q000031:analogs & derivatives; D006801:Humans; D011544:Pseudogenes; D013045:Species Specificity
D003568:Cytidine Monophosphate; D003596:Cytosine; D004262:DNA Restriction Enzymes; D015226:Dinucleoside Phosphates; D005914:Globins; D006147:Guanine; D006151:Guanosine; C015772:CpG dinucleotide