X-linked lymphoproliferative disease: a karyotype analysis.
X-linked lymphoproliferative disease (XLP) is triggered by Epstein-Barr virus. This virus is also associated with Burkitt lymphoma, a tumor that carries specific chromosome translocations. No such chromosome translocations have been observed in an analysis of XLP-derived cell lines. One XLP patient was found also to have Klinefelter syndrome, having inherited two copies of his maternal XLP-carrying X chromosome.
Harris
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Paediatric Research Unit, United Medical and Dental School of Guy's Hospital, London Bridge, UK.
Docherty
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Z
D002460:Cell Line; D004198:Disease Susceptibility; D004854:Herpesvirus 4, Human; D006801:Humans; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000150:complications; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000235:genetics*; D008297:Male; D010375:Pedigree; D014412:Tumor Virus Infections / Q000150:complications; D014960:X Chromosome