title: Peptide YY receptors in the brain.
abstract: Radiolabelled ligand binding studies demonstrated that specific receptors for peptide YY are present in the porcine as well as the canine brains. Peptide YY was bound to brain tissue membranes via high-affinity (dissociation constant, 1.39 X 10(-10)M) and low-affinity (dissociation constant, 3.72 X 10(-8)M) components. The binding sites showed a high specificity for peptide YY and neuropeptide Y, but not for pancreatic polypeptide or structurally unrelated peptides. The specific activity of peptide YY binding was highest in the hippocampus, followed by the pituitary gland, the hypothalamus, and the amygdala of the porcine brain, this pattern being similarly observed in the canine brain. The results suggest that peptide YY and neuropeptide Y may regulate the function of these regions of the brain through interaction with a common receptor site.
authors.affiliation: Second Department of Internal Medicine, School of Medicine, Kobe University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Inui
authors.forename: M
authors.initials: M
authors.lastname: Oya
authors.forename: M
authors.initials: M
authors.lastname: Okita
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: N
authors.initials: N
authors.lastname: Sakatani
authors.forename: H
authors.initials: H
authors.lastname: Morioka
authors.forename: K
authors.initials: K
authors.lastname: Shii
authors.forename: K
authors.initials: K
authors.lastname: Yokono
authors.forename: N
authors.initials: N
authors.lastname: Mizuno
authors.forename: S
authors.initials: S
authors.lastname: Baba
mesh_terms: D000679:Amygdala / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004285:Dogs; D006624:Hippocampus / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D007457:Iodine Radioisotopes; D007700:Kinetics; D009478:Neuropeptide Y / Q000378:metabolism; D019894:Peptide YY; D010455:Peptides / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism; D017476:Receptors, Neuropeptide Y; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013552:Swine; D013788:Thalamus / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D009478:Neuropeptide Y; D010455:Peptides; D017476:Receptors, Neuropeptide Y; D017981:Receptors, Neurotransmitter; D019894:Peptide YY