The role of serology in the diagnosis of Campylobacter pylori infection.
Circulating antibodies to Campylobacter pylori in patients with campylobacter-associated gastritis are sufficiently specific to allow serodiagnosis of this condition. This is possible by various techniques, the most convenient being enzyme-linked immunosorbent assay. Applications of serodiagnosis are in two areas--in clinical practice, where proper evaluation is still required, and in epidemiology. Here serodiagnosis shows the prevalence of C. pylori in the general population and in specific population groups. A study of C. pylori and dyspeptic symptoms in a group of healthy blood donors showed a significant association between C. pylori and history of peptic ulceration. However in most donors the gastritis was clinically silent.
Wyatt
J I
JI
St. James's University Hospital, Leeds, England.
Rathbone
B J
BJ
D000328:Adult; D001782:Blood Donors; D002167:Campylobacter / Q000276:immunology; D002169:Campylobacter Infections / Q000175:diagnosis* / Q000453:epidemiology; D004415:Dyspepsia / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012698:Serologic Tests
D007074:Immunoglobulin G