[Tumor syndromes with inappropriate renin secretion. Diagnostic criteria and review of published cases].
Besides the juxtaglomerular cell tumors, tumors may be responsible for a primary hyperreninism syndrome. Strict criteria allow to assert that the tumor cells themselves are involved in ectopic renin secretion. They are as follows:--measurement of the renin in the blood and in tumoral tissue extracts with assessment of active anf inactive renin,--absence of any other cause of hyperreninism,--regression of the hyperreninism when the tumor is removed, and possibly recurrence when metastases appear,--demonstration of renin antigen in tumor cells by immuno-histochemistry and more recently detection of renin messenger RNA using in situ hybridization with human renin probe. About 40 cases of these tumors have been described. They are mainly renal tumors: nephroblastomas (29 cases), adenocarcinomas (7 cases) and other rare tumors. Among extrarenal tumors, it has been observed epithelial tumors (broncho-pulmonary cancers, ovarian, fallopian and pituitary tumors), soft tissue tumors (alveolar sarcomas. epithelioid sarcoma, hemangiopericytoma, leiomyosarcoma). It has not been demonstrated that tumor cells from pheochromocytoma could be themselves involved in renin production.
Gaudemar
M
M
Service d'Anatomie Pathologique et d'Immunopathologie, INSERM U 28, Hôpital Broussais, Paris.
Bruneval
P
P
Camilleri
J P
JP
D000230:Adenocarcinoma / Q000378:metabolism; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D012083:Renin / Q000032:analysis / Q000378:metabolism*; D009396:Wilms Tumor / Q000378:metabolism
D012083:Renin
Syndromes tumoraux avec sécrétion inappropriée de rénine. Critères diagnostiques et revue des cas publiés.