title: Clinical problems of invasive hydatidiform mole in patients aged 40 or more.
abstract: Seventy-six patients with invasive hydatidiform mole (HM) were reviewed as to clinical course, particularly treatment and outcome, in relation to their age. The results were as follows: (i) metastatic cases showed approximately a twofold increase in patients over 40 compared with younger patients, (ii) more courses of chemotherapy were required to achieve a cure in patients over 40 than in younger patients and (iii) 4 of 19 patients (21.1%) over 40 developed choriocarcinoma, whereas none of younger patients did.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Niigata University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kanazawa
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Sasagawa
authors.forename: S
authors.initials: S
authors.lastname: Takeuchi
mesh_terms: D000328:Adult; D002822:Choriocarcinoma / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D002820:Hydatidiform Mole, Invasive / Q000175:diagnosis / Q000556:secondary / Q000628:therapy*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*