title: [Biological effects of coordinated compounds of transitional metals. 7. Antiviral activity of 4-methyl-2-aminopyridine palladium chloride against herpes simplex virus type 1 and type 2 in vitro and in vivo].
abstract: 4-Methyl-2-amino-pyridine-palladium chloride (MAP) showed an antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a serum-free medium under in vitro conditions. The replication of these viruses on primary rabbit testes cells was completely suppressed by 10(-5) M/l MAP. In animal tests using ABD2-mice the course of HSV-1 and HSV-2 encephalitis was not influenced by MAP indicated by mean survival time and lethality.
authors.affiliation: Medizinische Akademie Erfurt, Institut für Medizinische Mikrobiologie, DDR.
authors.forename: P
authors.initials: P
authors.lastname: Wutzler
authors.forename: K D
authors.initials: KD
authors.lastname: Thiel
authors.forename: M
authors.initials: M
authors.lastname: Tonew
authors.forename: E
authors.initials: E
authors.lastname: Tonew
authors.forename: H P
authors.initials: HP
authors.lastname: Schröer
authors.forename: A
authors.initials: A
authors.lastname: Stelzner
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002478:Cells, Cultured; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy*; D051379:Mice; D009942:Organometallic Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D010847:Picolines / Q000494:pharmacology* / Q000627:therapeutic use; D018139:Simplexvirus / Q000187:drug effects*; D013047:Specific Pathogen-Free Organisms
chemical_list: D000998:Antiviral Agents; D009942:Organometallic Compounds; D010847:Picolines; C032537:4-methyl-2-aminopyridine-palladium chloride
vernacular_title: Uber biologische Wirkungen von Koordinationsverbindungen der Ubergangsmetalle. 7. Zur antiviralen Wirksamkeit von 4-Methyl-2-amino-pyridinpalladiumchlorid gegenüber Herpes simplex-Virus Typ 1 und Typ 2 in vitro und in vivo.