title: PDGF-like growth factors in autocrine stimulation of growth.
abstract: PDGF is a dimeric molecule consisting of A chains and B chains. All three dimeric combinations have been found in platelets, or produced by certain normal or transformed cell types; whether functional differences occur between different dimers is currently under investigation. Production of PDGF-like factors by cells carrying PDGF receptors may establish an autocrine loop, driving cell multiplication.
authors.affiliation: Ludwig Institute for Cancer Research, Uppsala Branch, Sweden.
authors.forename: C H
authors.initials: CH
authors.lastname: Heldin
authors.forename: B
authors.initials: B
authors.lastname: Westermark
mesh_terms: D002455:Cell Division / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D002472:Cell Transformation, Viral / Q000187:drug effects; D005786:Gene Expression Regulation; D006801:Humans; D008938:Mitosis / Q000187:drug effects; D010982:Platelet-Derived Growth Factor / Q000235:genetics / Q000494:pharmacology*; D012842:Sarcoma Virus, Woolly Monkey / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D010982:Platelet-Derived Growth Factor