Aplastic anemia associated with type A viral hepatitis--possible role of T-lymphocytes.
Posthepatitic aplastic anemia (PHAA) is rather uncommon. Most reported cases have developed after non-A, non-B or B type hepatitis. The only case of PHAA occurring after hepatitis A reported so far, was described by Smith et al., who diagnosed it by the long-term elevation of IgG-class antibody in response to hepatitis A virus. Recently, the detection of IgM-class antibody specific against hepatitis A virus (IgM anti-HAV) has been commonly employed for precise diagnosis of hepatitis A. The case reported here is the first case of PHAA occurring after hepatitis A to be diagnosed by radioimmunoassay of IgM anti-HAV. Furthermore, evidence is presented suggesting that the PHAA may have been an immune-related response. Addition of the patient's peripheral T-lymphocytes to cultures of her own bone marrow cells resulted in a reduction in the number of colony-forming units in culture (CFU-C).
Aoyagi
K
K
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Ohhara
N
N
Okamurá
S
S
Otsuka
T
T
Shibuya
T
T
Yamano
Y
Y
Tsuda
Y
Y
Niho
Y
Y
D000328:Adult; D000741:Anemia, Aplastic / Q000209:etiology* / Q000276:immunology; D000914:Antibodies, Viral / Q000032:analysis; D003114:Colony-Forming Units Assay; D005260:Female; D006506:Hepatitis A / Q000150:complications* / Q000276:immunology; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007075:Immunoglobulin M / Q000032:analysis; D011863:Radioimmunoassay; D013601:T-Lymphocytes / Q000502:physiology*
D000914:Antibodies, Viral; D007075:Immunoglobulin M