Allergic reaction with immune hemolytic anemia resulting from chlorambucil.
In a 73-year-old female with chronic lymphocytic leukemia we observed an acute illness with shivering, high fever, and hemolytic anemia following chlorambucil administration. Reexposure in a controlled clinical situation suggested an allergic drug reaction. In an in vitro assay, we were able to demonstrate chlorambucil as the causative agent of immune hemolysis.
Thompson-Moya
L
L
Klinikum Charlottenburg der Freien Universität, Berlin, Federal Republic of Germany.
Martin
T
T
Heuft
H G
HG
Neubauer
A
A
Herrmann
R
R
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy*; D002699:Chlorambucil / Q000009:adverse effects* / Q000627:therapeutic use; D003298:Coombs Test; D004342:Drug Hypersensitivity / Q000175:diagnosis; D005260:Female; D006801:Humans; D012698:Serologic Tests
D002699:Chlorambucil