title: Condylomatous carcinoma of the vulva with special reference to human papillomavirus DNA.
abstract: Nine cases of condylomatous carcinoma (squamous cell carcinoma arising in condyloma acuminatum) of the vulva were studied for their clinical history, histopathology, and presence of human papillomavirus (HPV) DNA. Condylomatous carcinoma occurred primarily in an elderly population with a mean age of 70 years. There was an antecedent history of vulvar condyloma in 77%, with a median of nine months before the documentation of an invasive lesion. The disease had a good prognosis, with few recurrences and no metastasis or deaths from the disease. Human papillomavirus DNA was demonstrated to be present in 55% of these tumors by either filter or in situ hybridization techniques. Both HPV 6 and HPV 16 DNA were identified in an equal number of cases.
authors.affiliation: Department of Obstetrics and Gynecology, University of Minnesota, Minneapolis.
authors.forename: G O
authors.initials: GO
authors.lastname: Downey
authors.forename: T
authors.initials: T
authors.lastname: Okagaki
authors.forename: R S
authors.initials: RS
authors.lastname: Ostrow
authors.forename: B A
authors.initials: BA
authors.lastname: Clark
authors.forename: L B
authors.initials: LB
authors.lastname: Twiggs
authors.forename: A J
authors.initials: AJ
authors.lastname: Faras
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000032:analysis* / Q000401:mortality / Q000473:pathology; D003218:Condylomata Acuminata / Q000032:analysis* / Q000401:mortality / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000032:analysis / Q000401:mortality / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000032:analysis / Q000401:mortality / Q000473:pathology; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000235:genetics*; D011379:Prognosis; D014846:Vulvar Neoplasms / Q000032:analysis* / Q000401:mortality / Q000473:pathology
chemical_list: D004279:DNA, Viral