[Immunogenic properties of virus-specific soluble structural glycoproteins synthesized by chick embryo fibroblast cells infected with 2 strains of Aujeszky's disease virus].
Studied was the capacity of the soluble virus-specific glycoproteins of the virulent A-2 strain and its IUDR-resistant MK-25 mutant to induce the production of virus-neutralizing antibodies. It was found that both the purified virions and soluble glycoproteins of strain A-2 and those of strain MK-25 induced the release of virus-neutralizing antibodies in the injected rabbits. Use was made of affinity chromatography on Con-A-Sepharose to isolate the glycosylated virus-specific proteins. The quality of the soluble virus-specific glycoproteins to trigger the production of virus-neutralizing antibodies made it reasonable to believe that the virus glycoproteins are structural ones.
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D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000276:immunology / Q000302:isolation & purification; D000918:Antibody Specificity; D002642:Chick Embryo; D005347:Fibroblasts / Q000382:microbiology; D006023:Glycoproteins / Q000096:biosynthesis / Q000276:immunology* / Q000302:isolation & purification; D011558:Herpesvirus 1, Suid / Q000276:immunology* / Q000472:pathogenicity; D009154:Mutation; D011817:Rabbits; D012995:Solubility; D014764:Viral Proteins / Q000096:biosynthesis / Q000276:immunology* / Q000302:isolation & purification; D015678:Viral Structural Proteins; D014771:Virion / Q000276:immunology / Q000472:pathogenicity; D014774:Virulence; D014776:Virus Cultivation
D000914:Antibodies, Viral; D006023:Glycoproteins; D014764:Viral Proteins; D015678:Viral Structural Proteins
Imunogenni svoĭstva na virusspetsifichnite raztvorimi strukturni glikoproteini, sintezirani ot kletki KEF, zarazeni s dva shtama na virusa na Aueski.