[HIV serology in the early stage of an HIV infection].
Sera were available of 23 individuals before anti-HIV screening tests of the first generation became positive (seroconversion). HIV antigen (p24) became detectable before seroconversion in 21 individuals. HIV antigen disappeared before the first appearance of anti-HIV in 3 instances and shortly after seroconversion in another 17 individuals. As early as HIV-Ag, IgM anti-HIV also became detectable as measured by Western Blot, but these antibodies persisted longer. In 12 individuals anti-HIV as measured by a second generation screening test (using antigens produced by gene technology) also became positive before seroconversion. IgM anti-HIV and HIV-Ag are of help in early diagnosis of HIV infection but cannot be used as screening tests. For anti-HIV screening only tests of the second generation should be used.
Joller-Jemelka
H
H
Departement für Innere Medizin, Universitätsspital, Zürich.
Grob
P J
PJ
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D000914:Antibodies, Viral / Q000302:isolation & purification; D000956:Antigens, Viral / Q000302:isolation & purification; D017977:Deltaretrovirus / Q000276:immunology; D005260:Female; D015483:HIV Antibodies; D006679:HIV Seropositivity / Q000097:blood; D006801:Humans; D007158:Immunologic Techniques; D008297:Male
D000914:Antibodies, Viral; D000956:Antigens, Viral; D015483:HIV Antibodies
HIV-Serologie in der Frühphase einer HIV-Infektion.