title: The respiratory burst oxidase.
abstract: The respiratory burst oxidase is an activatable, membrane-bound flavo(?hemo) protein that catalyzes the NADPH-dependent reduction of oxygen to superoxide (O2-) in stimulated phagocytes. Chronic granulomatous disease, a group of disorders in which phagocytes cannot manufacture O2-, is caused by a biochemical lesion involving this oxidase or its activating system.
authors.affiliation: Division of Biochemistry, Research Institute of Scripps Clinic, La Jolla, California.
authors.forename: B M
authors.initials: BM
authors.lastname: Babior
mesh_terms: D003573:Cytochrome b Group / Q000032:analysis / Q000378:metabolism / Q000502:physiology; D004789:Enzyme Activation; D006105:Granulomatous Disease, Chronic / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009247:NADH, NADPH Oxidoreductases / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D009249:NADP / Q000378:metabolism; D019255:NADPH Oxidases; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D010586:Phagocytes / Q000201:enzymology* / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
chemical_list: D003573:Cytochrome b Group; D013481:Superoxides; D009249:NADP; C036888:cytochrome b558; D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases; C022709:superoxide-forming enzyme