title: Isolation of a hexaprenylhydroquinone sulfate from the marine sponge Dysidea sp. as an H,K-ATPase inhibitor.
abstract: A hexaprenylhydroquinone sulfate has been isolated as an H,K-ATPase inhibitor from a marine sponge Dysidea sp. It also inhibited phospholipase A2 as well as secretion of gastric acid in rats.
authors.affiliation: Laboratory of Marine Biochemistry, Faculty of Agriculture, University of Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Fusetani
authors.forename: M
authors.initials: M
authors.lastname: Sugano
authors.forename: S
authors.initials: S
authors.lastname: Matsunaga
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: H
authors.initials: H
authors.lastname: Shikama
authors.forename: A
authors.initials: A
authors.lastname: Ohta
authors.forename: H
authors.initials: H
authors.lastname: Nagano
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects; D017506:H(+)-K(+)-Exchanging ATPase; D009682:Magnetic Resonance Spectroscopy; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D054467:Phospholipases A2; D011161:Porifera / Q000032:analysis*; D051381:Rats; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D013729:Terpenes; C054388:hexaprenylhydroquinone sulfate; D010741:Phospholipases A; D054467:Phospholipases A2; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase