title: Nourseothricin (streptothricin) inactivated by a plasmid pIE636 encoded acetyl transferase: nature of the inactivated nourseothricin.
abstract: Nourseothricin, a mixture of several streptothricins, is inactivated by an acetyl transferase produced by Escherichia coli containing the plasmid pIE636. Nourseothricin inactivated in the presence of 14C-acetate was purified and submitted to partial hydrolysis. In the hydrolysate besides others a radioactive and ninhydrin-reactive substance moving only slightly towards the cathode was found. It proved to be [14C]-acetyl beta-lysine.
authors.forename: G
authors.initials: G
authors.lastname: Seltmann
authors.forename: W
authors.initials: W
authors.lastname: Beer
mesh_terms: D000107:Acetylation; D000123:Acetyltransferases / Q000235:genetics / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli; D010957:Plasmids; D013309:Streptothricins / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D013309:Streptothricins; D000123:Acetyltransferases