Both alpha- and beta-adrenoreceptors contribute to the central depressor effect of catecholamines.
We compared the effects of alpha 2- and beta-adrenoreceptor blockade on the central actions of catecholamines and metabolites of alpha-methyldihydroxyphenylalanine, epinephrine, alpha-methylnorepinephrine, and alpha-methylepinephrine were studied. I.c.v. and nucleus tractus solitarii (NTS) injections were carried out under anesthesia. Following i.c.v. injection, both epinephrine and methylepinephrine rapidly reduced blood pressure and heart rate, but the effects of methylnorepinephrine occurred somewhat later. Following microinjection into the nucleus of the solitary tract, epinephrine, methylepinephrine, and methylnorepinephrine all caused hypotension and bradycardia. The hypotensive effects of all 3 amines in the NTS were attenuated in additive fashion by yohimbine, an alpha 2 adrenoreceptor antagonist, and timolol, a beta-adrenoreceptor antagonist, whereas only yohimbine attenuated the bradycardia. The combination of yohimbine and timolol abolished the effects of the amines. These data suggest that in the NTS both alpha 2 and beta adrenoreceptor stimulation contribute to the hypotensive effects of these amines, but that only alpha 2 adrenoreceptors are principally involved in the heart rate response.
Tung
C S
CS
Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan.
Goldberg
M R
MR
Hollister
A S
AS
Robertson
D
D
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002395:Catecholamines / Q000494:pharmacology / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects*; D007276:Injections, Intraventricular; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology; D008771:Nordefrin / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D044005:Tetrahydroisoquinolines; D013999:Timolol / Q000494:pharmacology; D015016:Yohimbine / Q000494:pharmacology
D002395:Catecholamines; D007546:Isoquinolines; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D044005:Tetrahydroisoquinolines; D015016:Yohimbine; D013999:Timolol; C012153:7,8-dichloro-1,2,3,4-tetrahydroisoquinoline; D008771:Nordefrin; D011224:Prazosin