title: Inhibition of growth and development of the transplantable C-6 glioma cells inoculated in rats by retinoids and carotenoids.
abstract: Experimental data were provided to demonstrate the inhibitory effects of retinoids (retinal, retinoic acid, retinyl acetate and retinyl palmitate) and carotenoids (beta-carotene, lycopene and crocetin) on the growth and development of the C-6 glioma cells inoculated in rats. In the pretreatment experiments, most of these compounds could prolong the latency period of T50 (time for 50% tumor incidence). At week 7, the growth inhibition was 57-67% (P less than 0.02) with carotenoids and 40-55% (P less than 0.05) with retinoids. In the post-treatment experiments, the growth inhibition was 30-55% (P less than 0.05) with carotenoids and 21-42% (P less than 0.05) with retinoids. No significant hepatotoxic effect was observed in all treated groups as indicated by the constant levels of serum enzymes (e.g. aspartate amino-transferase, alanine amino-transferase and alkaline phosphatase) and bilirubin. The mechanisms of tumor inhibition through the enhancement of anti-tumor immunity by both carotenoids and retinoids were discussed.
authors.affiliation: Institute of Biochemistry, National Taiwan University, College of Medicine, ROC.
authors.forename: C J
authors.initials: CJ
authors.lastname: Wang
authors.forename: M Y
authors.initials: MY
authors.lastname: Chou
authors.forename: J K
authors.initials: JK
authors.lastname: Lin
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002338:Carotenoids / Q000627:therapeutic use*; D005910:Glioma / Q000188:drug therapy* / Q000473:pathology; D008099:Liver / Q000201:enzymology; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D012176:Retinoids / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
chemical_list: D012176:Retinoids; D002338:Carotenoids