title: Prolactin dynamics in a patient with isolated ACTH deficiency accompanied by hyperprolactinemia.
abstract: Case of isolated ACTH deficiency accompanied by hyperprolactinemia was reported. Prolactin (PRL) secretory dynamics were evaluated by several stimulation (thyrotropin-releasing hormone [TRH], sulpiride) and suppression (L-dopa) tests. Before glucocorticoid replacement therapy, both TRH and sulpiride administration resulted in PRL hyper-responsiveness. The sulpiride-induced PRL increase was higher than that induced by TRH. L-dopa administration resulted in normal PRL suppression. Following glucocorticoid replacement therapy, the elevated basal PRL level returned to normal, and PRL hyper-responsiveness to TRH or sulpiride also returned to normal. These data suggest that the elevation of basal PRL level and PRL hyper-responsiveness observed in this patient is caused by glucocorticoid deficiency.
authors.affiliation: Department of Internal Medicine, Kouritsu Yanase Hospital, Hyogo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shibutani
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000172:deficiency*; D000368:Aged; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000150:complications*; D007980:Levodopa; D008297:Male; D011388:Prolactin / Q000097:blood*; D013469:Sulpiride; D013973:Thyrotropin-Releasing Hormone
chemical_list: D007980:Levodopa; D013973:Thyrotropin-Releasing Hormone; D013469:Sulpiride; D000324:Adrenocorticotropic Hormone; D011388:Prolactin