title: Hepatic tumors with hyperglucagonemia. Response to treatment with human lymphoblastoid interferon.
abstract: A 62-year-old man had necrolytic migratory erythema in association with hyperglucagonemia and multiple hepatic tumors. A diagnosis of metastatic glucagonoma was made. He was treated with human lymphoblastoid interferon given subcutaneously in the dose of 2.8 to 7.1 X 10(6) IU/day. This produced a considerable fall in plasma glucagon and resolution of the associated rash. The treatment was continued for 10 weeks over a 4-month period. Computed tomography demonstrated a reduction in hepatic tumor mass.
authors.affiliation: Department of Medicine, St. James University Hospital, Leeds, England.
authors.forename: R A
authors.initials: RA
authors.lastname: Sheehan-Dare
authors.forename: A V
authors.initials: AV
authors.lastname: Simmons
authors.forename: J A
authors.initials: JA
authors.lastname: Cotterill
authors.forename: P G
authors.initials: PG
authors.lastname: Janke
mesh_terms: D007516:Adenoma, Islet Cell / Q000188:drug therapy*; D004890:Erythema / Q000188:drug therapy; D005935:Glucagonoma / Q000188:drug therapy*; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D007370:Interferon Type I