Hypomanic reactions to ACTH and prednisone treatment for multiple sclerosis.
Nine of 50 MS patients became hypomanic or manic during treatment with ACTH or prednisone. Symptoms did not occur with every drug exposure and were more common with ACTH. Patients at risk were identified by episodes of major depression before and after the onset of MS and by family histories of depression or alcoholism.
Minden
S L
SL
Division of Psychiatry, Brigham and Women's Hospital, Boston, MA 02115.
Orav
J
J
Schildkraut
J J
JJ
D000324:Adrenocorticotropic Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D001714:Bipolar Disorder / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy*; D011241:Prednisone / Q000009:adverse effects* / Q000627:therapeutic use
D000324:Adrenocorticotropic Hormone; D011241:Prednisone