Ocular toxicity after intravitreal injection of terconazole.
Terconazole, a new triazole antifungal agent, was injected intravitreally in doses ranging from 10 to 100 micrograms dissolved in dimethyl sulfoxide (DMSO) 60% into the eyes of New Zealand rabbits. Three control eyes received only DMSO. The eyes were evaluated with biomicroscopy, indirect ophthalmoscopy, electroretinography, and histopathologic examination. From these data, it was determined that an intravitreal injection containing a concentration of 10 micrograms/0.1 mL of terconazole is not toxic to the rabbit eye.
Schulman
J A
JA
Department of Ophthalmology, Louisiana State University Medical Center School of Medicine, Shreveport.
Peyman
G A
GA
Dietlein
J
J
Fiscella
R
R
Colantino
B
B
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use / Q000633:toxicity*; D004596:Electroretinography; D009877:Endophthalmitis / Q000188:drug therapy / Q000209:etiology; D005123:Eye / Q000187:drug effects* / Q000473:pathology; D009181:Mycoses / Q000188:drug therapy; D009887:Ophthalmoscopy; D011817:Rabbits; D014230:Triazoles / Q000627:therapeutic use / Q000633:toxicity*
D000935:Antifungal Agents; D014230:Triazoles; C037815:terconazole