Two domains within the early coding region of SV40 involved in the transformation of human fibroblasts.
The early gene products of simian virus 40 (SV40) transform human fibroblasts, whereas those of the human papovavirus BK (BKV) do not. The early gene products of both SV40 and BKV transform baby rat kidney cells. SV40-BKV chimerics were constructed which were able to transform baby rat kidney cells. Using the SV40-BKV chimerics, two domains within the SV40 large T protein were identified which are involved in the transformation of human fibroblasts.
de Ronde
A
A
Department of Virology, University of Amsterdam, The Netherlands.
Sol
C J
CJ
MacDonald
M E
ME
Koot
M
M
ter Schegget
J
J
van Strien
A
A
Wouters
E
E
van der Noordaa
J
J
D000818:Animals; D000957:Antigens, Viral, Tumor / Q000235:genetics; D001739:BK Virus / Q000235:genetics; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D005347:Fibroblasts; D005814:Genes, Viral; D006801:Humans; D007668:Kidney; D010957:Plasmids; D051381:Rats; D011994:Recombinant Proteins / Q000235:genetics; D013539:Simian virus 40 / Q000235:genetics*
D000957:Antigens, Viral, Tumor; D011994:Recombinant Proteins