Dosimetry of iodine-131 ethiodol in the treatment of hepatoma.
The in vivo distribution and kinetics of [131I]Ethiodol injected through the hepatic artery have been measured on a group of four patients with hepatocellular carcinoma. The [131I]Ethiodol was distributed predominantly in the liver (70-90%) and lungs (10-20%) and was selectively concentrated and retained in the patients with massive and multinodular hepatomas with approximately 10% of the administered activity localizing in tumor. The radioactivity in the blood 2 hr postinjection was less than 0.1% and was never higher than 0.9% of the administered activity. The radioactivity cleared from normal liver tissue with an effective half-life of approximately 4 days while the clearance time from the tumor was 20-25% longer. Activity in the lungs initially increased and then cleared with a 5-day effective half-life. Based on these measurements, the estimated dose per mCi of [131I]Ethiodol administered is 31 rad to the liver, 22 rad to the lungs, 1.9 rad to the total body and 239 rad to a 4-cm diameter tumor. These results suggest that [131I]Ethiodol has the potential to deliver curative radiation doses to hepatomas with acceptable radiation burdens to normal tissues.
Madsen
M T
MT
Dept. of Radiation Therapy & Nuclear Medicine, Thomas Jefferson University Hospital, Philadelphia, PA 19107.
Park
C H
CH
Thakur
M L
ML
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000532:radiotherapy*; D004998:Ethiodized Oil / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007269:Injections, Intra-Arterial; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D011879:Radiotherapy Dosage
D007457:Iodine Radioisotopes; D004998:Ethiodized Oil