Carboxyethyl gamma-aminobutyric acid, a polyamine derivative, improves the recovery of EBV-transformed lymphocytes.
A polyamine derivative, carboxyethyl - Aminobutyric Acid (CEGABA), induces the formation of a large number of Epstein-Barr Virus (EBV) transformed lymphocytes, when added to the culture medium immediately after EBV infection. However, CEGABA shows only a moderate effect on the stability of EBV-transformed cell lines over time, and does not affect the growth of stabilized cell lines. It is possible that CEGABA acts on cells other than EBV transformed lymphocytes (in fact, after EBV infection all types of mononuclear cells from the blood are present in the culture) and indirectly promotes the growth of EBV transformed lymphocytes.
Cerino
A
A
Istituto di Genetica Biochimica ed Evoluzionistica del C.N.R., Pavia, Italy.
Bestagno
M
M
Colonna
M
M
Fussi
F
F
Astaldi Ricotti
G C
GC
D000911:Antibodies, Monoclonal / Q000096:biosynthesis; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002472:Cell Transformation, Viral; D002999:Clone Cells / Q000276:immunology; D003524:Cyclosporins / Q000494:pharmacology; D004854:Herpesvirus 4, Human; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects / Q000276:immunology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D000911:Antibodies, Monoclonal; D003524:Cyclosporins; D007075:Immunoglobulin M; C044767:2-carboxyethyl gamma-aminobutyric acid; D005680:gamma-Aminobutyric Acid