Cyclic AMP derivatives injected into the inferior colliculus induce audiogenic seizure-like phenomena in normal rats.
Microinjection of 10 micrograms of either dibutyryl cyclic AMP or 8-bromo-cyclic AMP into the inferior colliculus of normal rats induced audiogenic seizure-like phenomena, which were intensified by sound stimulation. Microinjection of either cyclic AMP derivatives into areas surrounding the inferior colliculus or in the substantia nigra-region did not induce any such effects. These data suggest that there may be a close relationship between audiogenic seizures and cyclic AMP metabolism of the inferior colliculus.
Ludvig
N
N
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461.
Moshé
S L
SL
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology*; D000161:Acoustic Stimulation; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D004569:Electroencephalography; D007245:Inferior Colliculi / Q000502:physiology*; D007267:Injections; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology
D015124:8-Bromo Cyclic Adenosine Monophosphate; D003994:Bucladesine