Lack of effect of 28 days of neuroleptic treatment on platelet benzodiazepine binding sites in schizophrenics.
Twenty-eight days of neuroleptic treatment of 11 schizophrenics aged 16-23 years did not affect the binding values of 3H-PK 11195 to platelets. This lack of effect was in contrast to reduced peripheral benzodiazepine binding sites (PBS) observed in platelets of schizophrenics medicated over 2 years. These results may indicate that neuroleptic-induced down-regulation of PBS is a time-dependent phenomenon.
Tanne
Z
Z
Department of Pharmacology, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Weizman
R
R
Karp
L
L
Katz
Y
Y
Tyano
S
S
Gavish
M
M
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use*; D006801:Humans; D007546:Isoquinolines / Q000097:blood; D008297:Male; D011569:Psychiatric Status Rating Scales; D011963:Receptors, GABA-A / Q000187:drug effects*; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D014268:Trifluoperazine / Q000627:therapeutic use*
D007546:Isoquinolines; D011963:Receptors, GABA-A; D014268:Trifluoperazine; D006220:Haloperidol; C037850:PK 11195