Hypothermia induced by WR-2721 in the rat.
Hypothermic response to a range of doses of WR-2721 (S-2-/3 aminopropylamino/-ethylthiophosphate) was studied in the rat. Time of hypothermia appearance, time and extent of maximum hypothermia, and pattern of body temperature recovery were all observed to depend upon the level of drug dose administered. The role of such hypothermia in systemic toxicity of the drug is discussed. The authors believe it to result from insufficiency of thermoregulation in small mammals, and to be of no practical importance for clinical application of the drug.
Benova
D
D
Institute of Roentgenology and Radiobiology, Sofia, Bulgaria.
Kiradzhiev
G
G
Nikolova
M A
MA
D004999:Amifostine / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009946:Organothiophosphorus Compounds; D004999:Amifostine