DNA and S-phase distribution and incidence of metastasis in human primary lung carcinoma.
The aim of the study was to investigate the relationship between DNA and S-phase distribution in primary non-small-cell lung carcinomas with the incidence of metastasis. Patients with non-small-cell lung carcinomas were divided into two groups depending on whether at time of surgery there were metastases or not, and these groups were correlated with the data obtained by flow cytometry or autoradiography. As expected from other studies, survival time was significantly longer for those patients without metastases at time of surgery (P = .0002) and the incidence of metastasis was significantly higher when the primary tumor was greater than or equal to 70 cm3 (P = .026). In this study, a total of 185 fresh specimens of lung carcinomas were investigated by flow cytometry. Patients with aneuploid tumors had a higher tendency to have metastases (P = .016). Patients with tumors with a higher proportion of S-phase cells measured by either flow cytometry or autoradiography demonstrated significant increase in the formation of metastases (P = .02 and P = .05). We feel that these results warrant further investigation with other primary tumors. A comparison of primary tumors that are known to rapidly metastasize vs. those that either slowly or rarely metastasize may prove to yield valuable insight into the important factors associated with metastatic potential.
Volm
M
M
German Cancer Research Center, Institute of Experimental Pathology, Heidelberg.
Bak
M
M
Hahn
E W
EW
Mattern
J
J
Weber
E
E
D002289:Carcinoma, Non-Small-Cell Lung / Q000556:secondary*; D004247:DNA / Q000032:analysis* / Q000235:genetics; D005434:Flow Cytometry; D006801:Humans; D007399:Interphase; D008175:Lung Neoplasms / Q000556:secondary*
D004247:DNA