The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors.
The dogfish intestinal, linear tachykinin scyliorhinin I (SCYI) and cyclic tachykinin scyliorhinin II (SCYII) bound with differential selectivity to mammalian tachykinin, membrane receptor sites. SCYI bound with highest affinity to NK-1 sites in rat submandibular gland (KI = 0.9 nM) and to NK-2 sites in hamster urinary bladder (KI = 2 nM) whereas SCYII bound with highest affinity to NK-3 sites in rat cerebral cortex (KI = 2.5 nM). These results suggest that SCYI is a dual NK-1/NK-2 tachykinin receptor agonist while SCYII is an NK-3 selective tachykinin receptor agonist.
Buck
S H
SH
Merrell Dow Research Institute, Cincinnati, OH 45215.
Krstenansky
J L
JL
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D006224:Cricetinae; D004284:Dogfish / Q000378:metabolism*; D066298:In Vitro Techniques; D009842:Oligopeptides / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D018039:Receptors, Tachykinin; D012754:Sharks / Q000378:metabolism*; D013363:Submandibular Gland / Q000378:metabolism; D015320:Tachykinins; D001743:Urinary Bladder / Q000378:metabolism
D009842:Oligopeptides; D010455:Peptides; D017981:Receptors, Neurotransmitter; D018039:Receptors, Tachykinin; D015320:Tachykinins; C048918:scyliorhinin I; C048919:scyliorhinin II