[The immunohistochemical localization of CA 15-3 in human breasts and their tumors].
The tissue distribution of CA 15-3, a breast carcinoma associated antigenic determinant, has been investigated by an avidin-biotin immunoperoxidase technique in the human breasts and in their tumors. In cases of scirrhous carcinoma, positive stainings for CA 15-3 were observed in almost all carcinoma cells. In cases of solid-tubular carcinomas and papillotubular carcinomas, the reaction was various and there was no correlation between the distribution of CA 15-3 and the clinical stage. Apical staining was recognized in both solid-tubular and papillotubular carcinomas, in benign breast tumors, and in normal breast tissues. CA 15-3 appears to be related to the degree of differentiation of the breast tissue.
Ishikawa
T
T
Dept. of Obstet. & Gynecol., Kudanzaka Hospital.
Tanaka
Y
Y
Sugihara
K
K
Hatano
M
M
Kaneko
A
A
Motoji
K
K
Nasu
M
M
Okayasu
I
I
Sato
T
T
Inaba
N
N
D000230:Adenocarcinoma / Q000276:immunology; D000231:Adenocarcinoma, Papillary / Q000276:immunology; D002293:Adenocarcinoma, Scirrhous / Q000276:immunology; D000232:Adenofibroma / Q000276:immunology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate; D001940:Breast / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate