[Changes in the rate of lecithin cholesterol acyltransferase reaction and lipid indicators of serum under the effect of cathergene in acute experimental liver damage].
Fractional and molar rates of lecithin:cholesterol aminotransferase (LCAT)-catalyzed reaction were decreased, while free cholesterol fraction was increased in blood serum of rats within 24 hrs after single administration of CCl4 I mg/kg. Cathergene, contributing to a decrease in hepatocyte necrosis, affected positively the blood lipid spectrum in CCl4 treated rats. The cathergene protective effect, observed also after acute ethanol poisoning (6 g/kg), involved an increase by about 30% of the fractional and molar rates of LCAT-reactions; it also normalized the cholesterol esterification coefficient in blood serum. The drug did not prevent the postalcohol dystrophy of hepatocytes, hypertriglyceridemia, hypercholesterolemia.
Gaskina
T K
TK
Kurilovich
S A
SA
Gorchakov
V N
VN
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D002392:Catechin / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D000431:Ethanol / Q000633:toxicity; D008055:Lipids / Q000097:blood*; D008106:Liver Cirrhosis, Experimental / Q000097:blood* / Q000139:chemically induced / Q000473:pathology; D008297:Male; D009336:Necrosis; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D008055:Lipids; D000431:Ethanol; D002392:Catechin; D002784:Cholesterol; D002251:Carbon Tetrachloride; D007862:Phosphatidylcholine-Sterol O-Acyltransferase
Izmenie skorosti letsitinkholesterolatsiltransferaznoĭ reaktsii i lipidnykh pokazateleĭ syvorotki krovi pod vliianiem katergena v usloviiakh ostrogo éksperimental'nogo povrezhdeniia pecheni.