Influence of glibenclamide on the efficacy of calcium trisodium pentetat as an antidote for cadmium toxicity.
Cadmium causes hyperglycemia, activation of hepatic and renal gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1,6-diphosphatase, increases hepatic and renal zinc, renal copper and decreases hepatic and renal iron levels in rats. Glibenclamide, a hypoglycemic agent, significantly reversed most of the Cd effects, enhanced fecal excretion of Cd and potentiated urinary and fecal elimination of Cd by calcium trisodium diethylenetriaminepentaacetate (CaNa3DTPA), a commonly used metal chelator. However, the restoration of Cd-induced alterations in carbohydrate metabolism was not related to elimination of Cd from the tissues.
Tewari
P C
PC
Industrial Toxicology Research Centre, Lucknow, India.
Tandon
S K
SK
D000818:Animals; D002104:Cadmium / Q000378:metabolism / Q000652:urine; D002105:Cadmium Poisoning / Q000097:blood / Q000188:drug therapy*; D003300:Copper / Q000378:metabolism; D005243:Feces / Q000032:analysis; D006597:Fructose-Bisphosphatase / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005905:Glyburide / Q000627:therapeutic use*; D007501:Iron / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D004369:Pentetic Acid / Q000627:therapeutic use*; D051381:Rats; D015032:Zinc / Q000378:metabolism
D002104:Cadmium; D003300:Copper; D004369:Pentetic Acid; D007501:Iron; D006597:Fructose-Bisphosphatase; D005952:Glucose-6-Phosphatase; D015032:Zinc; D005905:Glyburide