Complement-mediated cytolytic activity associated with cytomegalovirus complement-fixing IgM antibody.
Cytomegalovirus-specific complement-fixing IgM (CMV CF-IgM) antibody was detected in 12/84 (14.3 percent) sera containing CMV-specific IgM. Higher titres were obtained by using a purified antigen preparation containing enveloped virus particles and membrane fragments when compared with a crude extract of infected cells, suggesting that the CF component of CMV IgM reacts predominantly with antigens on the surface of the infected cells. This also accounts for its complement-mediated cytolytic activity. Neither CMV-specific non-complement-fixing IgM nor CMV-specific IgG demonstrates cytolytic activity.
Booth
J C
JC
Department of Virology, St. George's Hospital Medical School, University of London, England.
Mohammed
H S
HS
D000914:Antibodies, Viral / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity; D000956:Antigens, Viral / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D066298:In Vitro Techniques
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007075:Immunoglobulin M; D003165:Complement System Proteins