Hepatocellular carcinoma: molecular biology, etiology and animal models.
Hepatocellular carcinoma (HCC) occurs uncommonly in the United States and Western Europe, but is a relatively frequent neoplasm in sub-Saharan Africa, China, and the Far East. Environmental factors appear to determine the geographic clustering of the disease and to cause different spectrums of the disease in the high-incidence and low-incidence areas of the world.
Dusheiko
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Liver Unit, University of the Witwatersrand Medical School, Johannesburg, South Africa.
D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis; D004279:DNA, Viral / Q000235:genetics* / Q000302:isolation & purification; D004195:Disease Models, Animal; D012739:Gonadal Steroid Hormones / Q000009:adverse effects; D006509:Hepatitis B / Q000150:complications; D006515:Hepatitis B virus / Q000235:genetics*; D006518:Hepatitis Viruses; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D008113:Liver Neoplasms / Q000209:etiology / Q000235:genetics; D009857:Oncogenes; D009858:Oncogenic Viruses / Q000235:genetics; D012190:Retroviridae / Q000235:genetics; D013045:Species Specificity
D002273:Carcinogens; D004273:DNA, Neoplasm; D004279:DNA, Viral; D012739:Gonadal Steroid Hormones