Psychotropic effects of repeated doses of enalapril, propranolol and atenolol in normal subjects.
1 Enalapril 20 mg, propranolol 160 mg, atenolol 50 mg and placebo each were given once a day for 8 days to 12 normal volunteers, using a Latin-square design and double-blind procedures. A battery of tests was applied before, 2 and 4 h after the dose on day 1 and 8. 2 EEG effects were detected on day 8 with propranolol but not consistently after atenolol or enalapril. 3 Reaction-time, symbol copying and memory were impaired with propranolol; only memory was marginally affected by atenolol. Enalapril impaired memory but improved tapping ability. 4 Subjectively, propranolol was associated with drowsiness, enalapril with calmness and perhaps contentedness. Ratings of headache were increased with enalapril. 5 It is concluded that the apparent beneficial subjective effects of enalapril in clinical practice are attributable partly to intrinsic central effects but mainly to the contrast with beta-adrenoceptor blockers such as propranolol.
Frcka
G
G
Department of Psychiatry, Institute of Psychiatry, De Crespigny Park, London.
Lader
M
M
D000328:Adult; D000339:Affect / Q000187:drug effects; D001262:Atenolol / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004656:Enalapril / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D011433:Propranolol / Q000008:administration & dosage*; D011619:Psychotropic Drugs / Q000008:administration & dosage*; D011930:Reaction Time / Q000187:drug effects
D011619:Psychotropic Drugs; D001262:Atenolol; D004656:Enalapril; D011433:Propranolol