Improved immediate function of renal allografts with Belzer perfusate.
The characteristics of 254 cadaveric kidneys were evaluated and the incidence of immediate function identified. The Belzer perfusate was used primarily (n = 140) and secondarily (n = 14) in combination with pulsatile machine perfusion. These two groups were compared with a previous group of kidneys machine-perfused with silica gel (cryoprecipitated human plasma). The incidence of immediate function of the group primarily perfused with Belzer perfusate was statistically significantly improved over that of the silica gel. The secondarily perfused Belzer group, "imported" kidneys previously preserved with simple cold storage, had notably longer periods of preservation and higher resistances on the machine. However, 100% of this group functioned immediately. Other findings in this study show that the Belzer perfusate allows for improved parenchymal function posttransplant, as noted by a more rapid clearance of serum creatinine posttransplant. When comparing the immediate function group with those suffering early dysfunction, there is a statistically significant increased resistance on the machine in the latter group. This allows for prediction of immediate function based on perfusion characteristics of the kidney. The Belzer perfusate, composed of metabolic substrates for high-energy phosphate production, improves the incidence of immediate function in machine-perfused kidneys, as well as improved qualitative function posttransplant. It also is effective as a "rescue" mechanism in previously simple cold-stored (ATP-depleted) kidneys.
Henry
M L
ML
Department of Surgery, Ohio State University College of Medicine, Columbus 43210.
Sommer
B G
BG
Ferguson
R M
RM
D000255:Adenosine Triphosphate; D000328:Adult; D002102:Cadaver; D003404:Creatinine / Q000097:blood; D005069:Evaluation Studies as Topic; D006801:Humans; D007668:Kidney / Q000502:physiology; D016030:Kidney Transplantation; D008274:Magnesium; D015636:Magnesium Chloride; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion; D058428:Silica Gel; D012822:Silicon Dioxide; D012996:Solutions; D013696:Temperature
D012996:Solutions; D015636:Magnesium Chloride; D058428:Silica Gel; D012822:Silicon Dioxide; D000255:Adenosine Triphosphate; D003404:Creatinine; D008274:Magnesium