Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.
Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.
Sircar
R
R
Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY.
Samaan
H
H
Nichtenhauser
R
R
Snell
L D
LD
Johnson
K M
KM
Rivier
J
J
Vale
W
W
Zukin
R S
RS
Zukin
S R
SR
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D001921:Brain / Q000502:physiology*; D008297:Male; D016202:N-Methylaspartate; D009638:Norepinephrine / Q000378:metabolism; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D017478:Receptors, Phencyclidine; D017480:Receptors, sigma
D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D011957:Receptors, Opioid; D017478:Receptors, Phencyclidine; D017480:Receptors, sigma; D001224:Aspartic Acid; D016202:N-Methylaspartate; D000109:Acetylcholine; D009638:Norepinephrine