Immunological conservation between Epstein-Barr virus and herpes simplex virus.
We have analysed Epstein-Barr virus (EBV)- and herpes simplex virus (HSV)-infected cells for evidence of antigenic conservation of virus-coded proteins. Immunofluorescence and Western blot analyses of EBV-transformed cell lines demonstrated the presence of proteins that are antigenically related to the HSV alkaline DNase, infected cell-specific protein 34/35, glycoprotein B, thymidine kinase and the major DNA-binding protein. These proteins were characterized on the basis of Mr and possible kinetic class.
Littler
E
E
Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, U.K.
Halliburton
I W
IW
Powell
K L
KL
Snowden
B W
BW
Arrand
J R
JR
D000956:Antigens, Viral / Q000032:analysis*; D002461:Cell Line, Transformed; D003429:Cross Reactions; D005455:Fluorescent Antibody Technique; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology*; D007118:Immunoassay; D007124:Immunoenzyme Techniques; D018139:Simplexvirus / Q000235:genetics / Q000276:immunology*; D014764:Viral Proteins / Q000032:analysis*
D000956:Antigens, Viral; D014764:Viral Proteins