Changes in endogenous prostaglandin levels during D-galactosamine-induced liver injury.
The role of prostaglandins (PGs) in liver injury induced by D-galactosamine was investigated in the rat. The contents of PGD2 and PGF2 alpha in the liver were significantly increased from 3 h and 24 h after the D-galactosamine administration, respectively, but that of PGE2 was not significantly changed. Administration of 16,16-dimethyl PGE2, a long acting derivative of PGE2, or indomethacin, but not 16,16-dimethyl PGF2 alpha, a long acting derivative of PGF2 alpha, significantly depressed the increase in the serum transaminase activities induced by D-galactosamine. The protective effect of indomethacin was not disturbed by the 16, 16-dimethyl PGF2 alpha administration. These results indicate that PGE2 has a cytoprotective effect against the D-galactosamine induced liver injury and suggest that the protective effect of indomethacin is ascribable to its suppression of synthesis of PGs other than PGE2 or PGF2 alpha, e.g., PGD2.
Koyama
Y
Y
Department of Internal Medicine, Faculty of Medicine, University of Nagoya, Japan.
Imoto
M
M
Tanaka
M
M
Fukuda
Y
Y
Satake
T
T
Ozawa
T
T
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D002851:Chromatography, High Pressure Liquid; D005688:Galactosamine; D007213:Indomethacin / Q000494:pharmacology; D008107:Liver Diseases / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009336:Necrosis / Q000139:chemically induced / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D011453:Prostaglandins; D005688:Galactosamine; D007213:Indomethacin