Acute effects of oral phosphate-salt ingestion on serum phosphorus, serum ionized calcium, and parathyroid hormone in young adults.
We studied the effect of acute oral phosphate loading on parathyroid hormone (PTH) secretion and action. Eighteen adults were studied before and after ingestion of 1 g elemental phosphorus as neutral sodium-potassium phosphate in grape juice or in water and 1.7 g NaCl in juice was used as a control. Five subjects were studied after ingesting 1.5 g P in juice. Blood was drawn every 15 min from -45 to +300 min for measurement of serum ionized calcium (Ca++), P, total Ca, creatinine, and immunoreactive PTH (iPTH); urine was collected hourly. Serum P declined after NaCl ingestion but rose significantly after ingestion of 1 g P in juice or in water. There were no significant changes in serum Ca++, iPTH, or urinary cyclic AMP excretion. Acute ingestion of 1-1.5 g P, which exceeds the P content of a normal meal, does not decrease serum Ca++ or increase iPTH secretion or renal action in normal adults.
Calvo
M S
MS
Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55902.
Heath
H
H
D000328:Adult; D002118:Calcium / Q000097:blood* / Q000652:urine; D002413:Cations, Divalent; D003404:Creatinine / Q000097:blood; D000242:Cyclic AMP / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D010758:Phosphorus / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology* / Q000652:urine; D012964:Sodium / Q000652:urine; D012965:Sodium Chloride / Q000494:pharmacology
D002413:Cations, Divalent; D010281:Parathyroid Hormone; D010758:Phosphorus; D012965:Sodium Chloride; D012964:Sodium; D003404:Creatinine; D000242:Cyclic AMP; D002118:Calcium