[Kafamycin--a new pyrrol ether antibiotic].
Cafamycin is a novel polyether antibiotic active against gram-positive bacteria. It was isolated from the culture fluid of Streptomyces sp., an organism producing the anthracycline antibiotic galtamycin. The structure of cafamycin was assessed by spectral analysis: UV, PMR, mass spectroscopy and CD. Physico-chemical and biological properties of the antibiotic are described. Cafamycin was shown to be an analog of indanomycin (X-14547A), a pyrrol ether antibiotic.
Murenets
N V
NV
Kudinova
M K
MK
Korobkova
T P
TP
Drobysheva
T N
TN
Kliuev
N A
NA
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002942:Circular Dichroism; D004578:Electron Spin Resonance Spectroscopy; D005658:Fungi / Q000187:drug effects; D005663:Furans / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D013058:Mass Spectrometry; D009279:Naphthacenes / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D005663:Furans; D009279:Naphthacenes; C054967:cafamycin
Kafamitsin--novyĭ pirroléfirnyĭ antibiotik.