The action of recombinant bovine interferons on influenza virus replication correlates with the induction of two Mx-related proteins in bovine cells.
Recombinant bovine interferon-alpha and -gamma differ in their action against influenza virus on bovine cells. Bovine IFN-alpha severely impairs early protein synthesis and replication of influenza virus in bovine cells in contrast to bovine IFN-gamma which fails to induce an antiviral state against influenza virus. Otherwise the IFN system seems to function normally in bovine cells since both bovine IFN-alpha and -gamma induce an antiviral state against vesicular stomatitis virus. The establishment of the specific antiviral state against influenza virus correlates with the induction by bovine IFN-alpha, but not -gamma, of two cytoplasmic proteins related to the IFN-induced mouse protein Mx involved in the mechanism of resistance of mice to influenza virus infection. This study suggests that bovines possess a system for resistance to influenza virus similar to the mouse Mx system.
Horisberger
M A
MA
Pharmaceuticals Research, Biotechnology, Ciba-Geigy Ltd., Basle, Switzerland.
D000818:Animals; D002417:Cattle; D019204:GTP-Binding Proteins; D009980:Influenza A virus / Q000254:growth & development; D007370:Interferon Type I / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D007526:Isoelectric Point; D008970:Molecular Weight; D064547:Myxovirus Resistance Proteins; D011506:Proteins / Q000502:physiology*; D011994:Recombinant Proteins / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development; D014762:Viral Interference; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects
D007370:Interferon Type I; C579070:Mx1 protein, mouse; D064547:Myxovirus Resistance Proteins; D011506:Proteins; D011994:Recombinant Proteins; D014764:Viral Proteins; D007371:Interferon-gamma; D019204:GTP-Binding Proteins