title: Renal function in urinary schistosomiasis in the Natal Province of South Africa.
abstract: Renal function was assessed in 101 schoolchildren with active urinary schistosomiasis by measuring serum creatinine, urate, urea, and B2-microglobulin, urinary B2 microglobulin, and the glomerular filtration rate. Glomerular function in all subjects was normal as were serum creatinine, urate, and urea levels. Serum B2-microglobulin was elevated in only 8% of subjects while urinary B2-microglobulin only was raised in 7% of subjects, indicating proximal tubular dysfunction, a previously unreported feature in urinary schistosomiasis. Urinary tract abnormalities were found in 43% of subjects consenting to an excretory urogram but no correlation with biochemical parameters of renal function was noted. Serum angiotensin converting enzyme level measured in 70 subjects was elevated in 11% of subjects and was regarded as a possible measure of increased granulomatous activity.
authors.affiliation: Research Institute for Diseases in a Tropical Environment, South African Medical Research Council, Congella.
authors.forename: R M
authors.initials: RM
authors.lastname: Coopan
authors.forename: K
authors.initials: K
authors.lastname: Naidoo
authors.forename: I
authors.initials: I
authors.lastname: Jialal
mesh_terms: D000293:Adolescent; D002648:Child; D003404:Creatinine / Q000032:analysis; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000652:urine; D011223:Praziquantel / Q000627:therapeutic use; D012553:Schistosomiasis haematobia / Q000097:blood* / Q000188:drug therapy / Q000453:epidemiology; D013019:South Africa; D014527:Uric Acid / Q000032:analysis; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D001613:beta 2-Microglobulin; D014527:Uric Acid; D011223:Praziquantel; D003404:Creatinine; D007703:Peptidyl-Dipeptidase A