A streptothricin-like antibiotic mixture, A-269A (and A-269A').
A streptothricin-like antibiotic, A-269A (referred to as A-269A hereafter) was isolated from the culture broth of Streptomyces sp., strain No. A-269. In this paper, the characterization of the producer, and the production, isolation, physico-chemical properties and biological properties of A-269A are reported. The structure of the antibiotic was also examined by 1H NMR, 13C NMR and fast atom bombardment mass spectra studies. From the spectroscopic data, A-269A was assumed to be a mixture of antibiotic LL-BL 136 and an isomeric compound in which the carbamoyl group is substituted on C-12' hydroxyl instead of C-10 hydroxyl.
Kido
Y
Y
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Furuie
T
T
Suzuki
K
K
Sakamoto
K
K
Yokoyama
Y
Y
Uyeda
M
M
Kinjyo
J
J
Yahara
S
S
Nohara
T
T
Shibata
M
M
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D008401:Gas Chromatography-Mass Spectrometry; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000032:analysis*; D013309:Streptothricins / Q000302:isolation & purification* / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C054845:A 269A; D013309:Streptothricins