Ageing and alpha 1 adrenoceptors in the iris.
This study was undertaken to determine if the age related decrease in pupil size is attributable to altered sympathetic adrenoceptor responsiveness. Log dose response curves using the selective alpha 1 agonist phenylephrine and antagonist thymoxamine showed that there is no difference in alpha 1 adrenoceptor sensitivity in the elderly and the young. Therefore age related miosis is not caused by an alteration in alpha 1 receptors with age.
Buckley
C
C
Research Department, Royal Victoria Eye and Ear Hospital, Dublin.
Curtin
D M
DM
Docherty
J
J
Eustace
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007498:Iris / Q000502:physiology*; D013948:Moxisylyte / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*
D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine; D013948:Moxisylyte