Influence of heparin and a low molecular weight heparin fraction of the leukocytes in an experimental venous thrombosis model.
A randomized study was performed to observe the effects induced by heparin and a low molecular weight heparin fraction (at different dosages) on the leukocytes of rats in the presence of experimental venous thrombosis. The experimentation was carried out on two series of animals: the first with a ligature of the inferior vena cava inducing the formation of a thrombus, the second without any ligature. The results show that the induction of thrombosis involves: in the blood, an increase of the number leukocytes, principally polymorphonuclear cells; in the thrombi, a significant rise in the total count of leukocytes, here mononuclear cells; the latter number increases with the dosages of the administered drugs.
Doutremepuich
C
C
Laboratoire d' Hématologie, Université de Bordeaux II, France.
Toulemonde
F
F
de Seze
O
O
Pereira
F
F
Anne
M C
MC
Doutremepuich
F
F
D000818:Animals; D006493:Heparin / Q000494:pharmacology* / Q000627:therapeutic use; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology* / Q000627:therapeutic use; D007958:Leukocyte Count; D007962:Leukocytes / Q000145:classification / Q000187:drug effects*; D007964:Leukocytosis / Q000209:etiology / Q000473:pathology; D008297:Male; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains; D013924:Thrombophlebitis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
D006495:Heparin, Low-Molecular-Weight; D006493:Heparin