Clinical applications of monoclonal antibodies in renal allograft biopsies.
This study details the use of immunoperoxidase stains by monoclonal antibodies of core renal biopsy tissue. Subset analysis by appropriate monoclonal antibody is discussed with particular reference to the amount of, role for, and morphologic place of the various infiltrating cells. The role of monoclonal antibody staining of interleukin 2 (IL-2) receptor bearing lymphocytes and HLA class II antigen positive cells is also discussed. It was concluded that immunoperoxidase marker studies can determine the cell types, identify their location and functional status. This might be potentially useful for prognosis and for diagnosis of rejection and cyclosporine toxicity.
Colvin
R B
RB
Department of Pathology, Massachusetts General Hospital, Boston 02114.
D000208:Acute Disease; D000911:Antibodies, Monoclonal; D001706:Biopsy; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000473:pathology; D006084:Graft Rejection; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007668:Kidney / Q000276:immunology / Q000473:pathology*; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D016030:Kidney Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
D000911:Antibodies, Monoclonal; D006680:HLA Antigens