Structure and mobilization of an ampicillin and gentamicin resistance determinant.
A DNA segment originally found in an epidemic plasmid of Escherichia coli encoding an aminoglycoside-(3)-N-acetyltransferase gene (aacC5) and a TEM-type beta-lactamase gene was characterized. The two genes were adjacent and constituted a single transcriptional unit. In addition, these genes were simultaneously mobilized through the action of an insertion sequence related to IS26, IS140, and IS15-delta. This DNA segment is a composite transposon which has been called Tn2922.
Martin
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C
Gomez-Lus
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Ortiz
J M
JM
Garcia-Lobo
J M
JM
D000667:Ampicillin / Q000494:pharmacology*; D001483:Base Sequence; D003470:Culture Media; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000032:analysis* / Q000302:isolation & purification / Q000648:ultrastructure; D005798:Genes, Bacterial; D005839:Gentamicins / Q000494:pharmacology*; D008854:Microscopy, Electron; D009154:Mutation; D010403:Penicillin Resistance / Q000235:genetics; D010957:Plasmids; D014158:Transcription, Genetic
D003470:Culture Media; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D005839:Gentamicins; D000667:Ampicillin