Blood elements at surfaces: platelets.
This brief review is designed to highlight the limitations of our knowledge given the difficulties in simulating the in vivo condition in models established in vitro and ex vivo. Despite this uncertainty, mounting evidence indicates that the GPIIb-IIIa receptor mediates crucial platelet functions and that control over its interactions may offer the potential for altering platelet behavior in vivo. Since this receptor appears to be part of a generalized family of adhesive protein receptors that utilize the tripeptide RGD as a recognition signal, insights derived from platelet function may have broad biological implications.
Coller
B S
BS
Division of Hematology, State University of New York at Stony Brook 11794.
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D001798:Blood Proteins / Q000502:physiology*; D006801:Humans; D010980:Platelet Membrane Glycoproteins / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology
D001798:Blood Proteins; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface