title: Quantitative analysis of resistance and cross-resistance to cytotoxic agents by tumour cell lines.
abstract: The published literature describing the spectrum of resistance and cross-resistance to cytotoxic agents by human and murine tumour cell lines maintained in long-term culture is reviewed. The data available demonstrate that for many cytotoxic agents, especially those of higher molecular weight, cross-resistance is proportional to the degree of resistance against the selecting agent. Furthermore, the degree of cross-resistance correlates with the molecular weight of the drug in adriamycin-, vincristine- and colchicine-resistant cell lines.
authors.affiliation: Department of Experimental Pathology, German Cancer Research Center, Heidelberg.
authors.forename: J
authors.initials: J
authors.lastname: Mattern
authors.forename: L
authors.initials: L
authors.lastname: Edler
authors.forename: M
authors.initials: M
authors.lastname: Volm
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002460:Cell Line; D004351:Drug Resistance; D006801:Humans; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents