[Fatal toxic epidermolysis following administration of allopurinol].
Six days after initiating therapy with allopurinol, toxic epidermal necrolysis developed in a 73-year-old man with renal failure. It was responsible for a generalized vasculitis and gastrointestinal bleeding ultimately leading to death. The authors emphasize the need for a careful evaluation before prescribing this medication, particularly in patients with renal failure.
Coutellier
P
P
Delgrange
B
B
D000368:Aged; D000493:Allopurinol / Q000009:adverse effects* / Q000627:therapeutic use; D004820:Epidermolysis Bullosa / Q000139:chemically induced* / Q000150:complications; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000150:complications; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D014527:Uric Acid / Q000097:blood; D014657:Vasculitis / Q000139:chemically induced / Q000150:complications
D014527:Uric Acid; D000493:Allopurinol
Epidermolyse toxique fatale après prise d'allopurinol.