Unilateral eyelid suture increases GABAA receptors in cat visual cortex.
We have examined the number, characteristics and distribution of GABAA receptor in the visual cortex of normal cats and in cats monocularly deprived by unilateral eyelid suture from early in postnatal life. Receptor densities were about 100% higher in the deprived animals than in their normal counterparts. No changes in receptor affinity were noted. The GABAA receptor increase appeared to affect all laminae in the visual cortex. The results suggest that an increase in GABAA receptors may underlie or result from the physiological consequences of early monocular deprivation.
Shaw
C
C
Department of Ophthalmology, University of British Columbia, Vancouver, Canada.
Cynader
M
M
D000367:Age Factors; D000818:Animals; D002415:Cats; D007839:Functional Laterality / Q000502:physiology*; D007700:Kinetics; D009118:Muscimol / Q000378:metabolism; D011963:Receptors, GABA-A / Q000378:metabolism*; D014793:Visual Cortex / Q000378:metabolism* / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D011963:Receptors, GABA-A; D009118:Muscimol; D005680:gamma-Aminobutyric Acid