title: Interferon sequence homology and receptor binding activity of ovine trophoblast antiluteolytic protein.
abstract: Sequencing of the 40 N-terminal amino acids of the blastocyst protein responsible for blocking corpus luteum regression in early pregnancy in sheep revealed a 37% homology with human alpha-interferon; 28% of the remaining amino acid changes were conservative. 125I-Labelled human alpha-interferon bound to membrane receptors from sheep uteri with an approximate Kd of 4 x 10(-11) M; binding was inhibited by unlabelled alpha-interferon or purified blastocyst antiluteolytic protein. The blastocyst antiluteolytic protein therefore closely resembles the interferon-alpha family of antiviral proteins.
authors.affiliation: AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge.
authors.forename: H J
authors.initials: HJ
authors.lastname: Stewart
authors.forename: S H
authors.initials: SH
authors.lastname: McCann
authors.forename: P J
authors.initials: PJ
authors.lastname: Barker
authors.forename: K E
authors.initials: KE
authors.lastname: Lee
authors.forename: G E
authors.initials: GE
authors.lastname: Lamming
authors.forename: A P
authors.initials: AP
authors.lastname: Flint
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005260:Female; D007370:Interferon Type I / Q000378:metabolism*; D008186:Luteolytic Agents / Q000037:antagonists & inhibitors; D008969:Molecular Sequence Data; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012756:Sheep
chemical_list: D007370:Interferon Type I; D008186:Luteolytic Agents; D011257:Pregnancy Proteins; D011956:Receptors, Cell Surface; C020947:interferon tau