title: [Na,K-ATPase from the outer kidney medulla of spontaneously hypertensive rats in ontogenesis].
abstract: Specific activity of Na,K-ATPase from kidney outer medulla microsomes of spontaneously hypertensive rats (SHR) and of normotensive Kyoto-Wistar rats (WKY) at different stages of ontogenesis was studied. A positive correlation was observed between the blood pressure level and specific Na,K-ATPase activity in SHR kidney medulla. At the malignant stage of the disease, the specific activity of Na,K-ATPase exceeded that of control by 67%. The inhibiting effect of blood serum from SHR on purified preparations of Na,K-ATPase was far more pronounced than that of WKY.
authors.forename: A A
authors.initials: AA
authors.lastname: Boldyrev
authors.forename: S N
authors.initials: SN
authors.lastname: Orlov
authors.forename: I A
authors.initials: IA
authors.lastname: Svinukhova
authors.forename: N U
authors.initials: NU
authors.lastname: Stetsiuk
mesh_terms: D000375:Aging; D000818:Animals; D005260:Female; D006973:Hypertension / Q000201:enzymology*; D007679:Kidney Medulla / Q000201:enzymology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors* / Q000097:blood; D013997:Time Factors
chemical_list: D000254:Sodium-Potassium-Exchanging ATPase
vernacular_title: Na,K-ATFaza naruzhnoĭ medully pochki spontanno gipertenzivnykh krys v ontogeneze.