title: A clinical trial using a regimen which includes a norgestomet implant and norgestomet plus oestradiol valerate injection as a treatment for anoestrus in dairy cows.
abstract: In seasonally calving dairy herds in the Macalister Irrigation Area of Gippsland, Victoria, cows that had not been observed in oestrus by the start of the mating season and which had inactive ovaries based on rectal palpation and progesterone assay were treated with a hormonal treatment (n = 49). Mature cows had calved at least 40 days previously and 2-year-olds had been calved at least 60 days. The treatment consisted of a norgestomet implant and a norgestomet and oestradiol injection on day 1; prostaglandin analogue Prosolvin) on day 8; withdrawal of implant on day 10 and an injection of PMSG; and fixed time artificial insemination 54 to 56 h after implant withdrawal. This treatment was called the Syncro-mate regimen. Control cows (n = 46) were injected with water on days 1, 8 and 10 and artificially inseminated or served by a bull when seen on heat. Forty seven percent of the treated cows became pregnant within 14 days from the start of treatment compared with 20% of control cows (P less than 0.01). There was an effect of age group on the response to treatment. A greater proportion of 2-year-old cows than mature cows became pregnant within 14 days of treatment (79% of 19 v. 27% of 20; Chi square interaction, treatment by age, 6.4, P less than 0.05). In the younger cows there was also a gain of 22 days in the treatment to conception interval over the control cows (P less than 0.001). It was concluded that the Syncro-mate regimen can be an effective treatment for post partum anoestrus in dairy cows under certain conditions.
authors.forename: D B
authors.initials: DB
authors.lastname: Galloway
authors.forename: P
authors.initials: P
authors.lastname: Brightling
authors.forename: J
authors.initials: J
authors.lastname: Malmo
authors.forename: G A
authors.initials: GA
authors.lastname: Anderson
authors.forename: M T
authors.initials: MT
authors.lastname: Larcombe
authors.forename: P J
authors.initials: PJ
authors.lastname: Wright
mesh_terms: D000780:Anestrus / Q000187:drug effects*; D000818:Animals; D002417:Cattle / Q000502:physiology*; D004343:Drug Implants; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage / Q000494:pharmacology; D004971:Estrus / Q000187:drug effects*; D005260:Female; D007267:Injections / Q000662:veterinary; D010062:Ovulation Induction / Q000662:veterinary; D011247:Pregnancy; D011282:Pregnenediones / Q000008:administration & dosage / Q000494:pharmacology*; D011372:Progestins / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D004343:Drug Implants; D004966:Estrogens, Conjugated (USP); D011282:Pregnenediones; D011372:Progestins; C100284:norgestomet; D004958:Estradiol