Leukocyte activation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism.
Chemoattractant receptors on leukocytes are coupled to a guanine nucleotide regulatory (N or G) protein that stimulates a membrane-associated phospholipase C to hydrolyze phosphatidylinositol 4,5-biphosphate. The products of this hydrolysis are inositol 1,4,5-trisphosphate and 1,2-diacylglycerol, which act as second messengers by raising intracellular levels of Ca++ and activating protein kinase C, respectively. These processes promote cellular activation but also initiate reactions that feed back to inhibit the stimulatory pathway.
Snyderman
R
R
Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710.
Verghese
M W
MW
D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000201:enzymology / Q000502:physiology*; D008954:Models, Biological; D009240:N-Formylmethionine Leucyl-Phenylalanine; D010586:Phagocytes / Q000201:enzymology / Q000502:physiology*; D010587:Phagocytosis; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000378:metabolism*; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic / Q000502:physiology*; D010738:Type C Phospholipases / Q000378:metabolism
D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic; D009240:N-Formylmethionine Leucyl-Phenylalanine; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins