[Directed biosynthesis of prostaglandin F2 alpha multiple labeled with tritium].
By selecting specific activators of PGF reductase and determining their optimal ratio, we have performed the directed biosynthesis of PGF2 alpha with a 45-50% yield. With the use of [5,6,8,9,11,12,14,15-3H8]arachidonic acid, multiple-labelled PGF2 alpha with molar radioactivity 6.1 TBe/mmol has been synthesised.
Iakusheva
L A
LA
Nagaev
I Iu
IIu
Lazurkina
T Iu
TIu
Shevchenko
V P
VP
Miagkova
G I
GI
D011452:15-Oxoprostaglandin 13-Reductase / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D015237:Dinoprost; D007553:Isotope Labeling; D011460:Prostaglandins F / Q000096:biosynthesis*; D014316:Tritium
D011460:Prostaglandins F; D014316:Tritium; D015237:Dinoprost; D011452:15-Oxoprostaglandin 13-Reductase
Napravlennyĭ biosintez kratnomechennogo tritiem prostaglandina F2 alpha.