Dendritic cells from human tissues express receptors for the immunoregulatory vitamin D3 metabolite, dihydroxycholecalciferol.
Dendritic cells have been isolated from human tonsillar tissue and shown to act as accessory cells in a mitogenic response. The dendritic cells will induced receptors for the active metabolite of vitamin D3, 1,25(OH)2D3, in the responder E+ T cells. The dendritic cells themselves constitutively express receptors for the metabolite, and this distinguishes them from other non-T cells in lymphomedullary tissue. Expression of the 1,25(OH)2D3 receptor may be a dendritic cell property that facilitates their accessory cell role within the tissue microenvironment.
Brennan
A
A
Bland-Sutton Institute of Pathology, University College and Middlesex School of Medicine, London, U.K.
Katz
D R
DR
Nunn
J D
JD
Barker
S
S
Hewison
M
M
Fraher
L J
LJ
O'Riordan
J L
JL
D002117:Calcitriol / Q000494:pharmacology; D002455:Cell Division; D003208:Concanavalin A / Q000494:pharmacology; D003713:Dendritic Cells / Q000032:analysis*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D014066:Palatine Tonsil / Q000276:immunology; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid / Q000032:analysis*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
D018167:Receptors, Calcitriol; D011987:Receptors, Steroid; D003208:Concanavalin A; D002117:Calcitriol