[Cells of patients with ataxia telangiectasia show a normal capacity of radio-induced reactivation of damaged HSV-1 virus].
Herpes Simplex Virus (HSV-1) was used to probe the expression of enhanced reactivation (ER) in cells from patients with ataxia telangiectasia (AT). The survival of UV-irradiated HSV-1 was increased as a result of UV- or X-preirradiation of both AT and normal cells. This result contrasts with our previous observation showing that contrary to normal cells AT cells are deficient for ER of a single-stranded DNA parvovirus. A difference between the molecular processes underlying ER of single- and double-stranded DNA viruses might explain these results.
Hilgers
G
G
MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, United Kingdom.
Abrahams
P J
PJ
Schouten
R
R
Cornelis
J J
JJ
Lehmann
A R
AR
Van der Eb
A J
AJ
Rommelaere
J
J
D000818:Animals; D001260:Ataxia Telangiectasia / Q000382:microbiology / Q000473:pathology*; D004277:DNA, Single-Stranded / Q000528:radiation effects; D004279:DNA, Viral / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D018139:Simplexvirus / Q000254:growth & development / Q000528:radiation effects*; D014775:Virus Activation
D004277:DNA, Single-Stranded; D004279:DNA, Viral
Les cellules de patients atteints d'ataxia telangiectasia manifestent une capacité normale de réactivation radioinduite du virus HSV-I endommagé.