[Complement activation after the intravascular administration of contrast media: a comparison between ionic and nonionic x-ray contrast media].
The effects of intravascular radiographic contrast media on the complement system were investigated in 46 patients. An ionic (sodium-/meglumine amidotrizoate, n = 22) or a non-ionic (iohexol, n = 24) contrast agent was applied for an i.v. urography. The levels of the complement-compounds C1q, C3, C5 and of the C1 inhibitor were determined at the end of the infusion and 20 minutes later. In both groups we obtained a significant (p less than 0.01) decrease of C3 during infusion for 10 to 15%. 20 minutes later these values were almost normalized again. Infusion of iohexol additionally caused a marked consumption of C5 and C1q (reduction to 85%), while the ionic contrast agent had no significant effect on these components. Both contrast media caused a decrease of the C1-inhibitor levels. Our results demonstrate an activation of the complement system by i.v. application of radiographic contrast media. The decrease of the C1q-level due to infusion of iohexol indicates an additional involvement of the classical activation pathway of the complement cascade.
Hoffmeister
H M
HM
Medizinische Klinik, Abt. III, Universität Tübingen.
Fuhrer
G
G
Platten
H P
HP
Heller
W
W
D003166:Complement Activating Enzymes / Q000032:analysis; D003167:Complement Activation / Q000187:drug effects*; D003172:Complement C1 / Q000032:analysis; D003174:Complement C1 Inactivator Proteins / Q000097:blood; D015922:Complement C1q; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003182:Complement C5 / Q000032:analysis; D003287:Contrast Media / Q000008:administration & dosage*; D003973:Diatrizoate / Q000008:administration & dosage; D003974:Diatrizoate Meglumine / Q000008:administration & dosage; D004338:Drug Combinations / Q000008:administration & dosage; D006801:Humans; D007472:Iohexol / Q000008:administration & dosage; D013997:Time Factors; D014567:Urography
D003172:Complement C1; D003174:Complement C1 Inactivator Proteins; D003176:Complement C3; D003181:Complement C4; D003182:Complement C5; D003287:Contrast Media; D004338:Drug Combinations; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D007472:Iohexol; D015922:Complement C1q; C027278:urovision; D003166:Complement Activating Enzymes
Komplementaktivierung nach intravaskulärer Kontrastmittelgabe: Vergleich zwischen ionischen und nicht-ionischen Röntgenkontrastmitteln.