title: Norfloxacin resistance in a clinical isolate of Escherichia coli.
abstract: Analysis of DNA gyrase supercoiling and of norfloxacin uptake in Escherichia coli GN14176, a moderately norfloxacin-resistant clinical isolate, indicated that resistance was associated with both an altered drug target and a reduction in drug uptake.
authors.affiliation: Episome Institute, Gunma, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Aoyama
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: S
authors.initials: S
authors.lastname: Mitsuhashi
mesh_terms: D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000378:metabolism / Q000494:pharmacology*; D014552:Urinary Tract Infections / Q000382:microbiology
chemical_list: D004250:DNA Topoisomerases, Type II; D009643:Norfloxacin