[Is there a relation between the presence in the serum of patients with arterial hypertension of a protein component with molecular weight of 15 kD and the inhibitory effect of the serum on Na,K-ATPase?].
Blood sera from patients with arterial hypertension exhibited more distinct inhibitory effect on purified Na+,K+-ATPase as compared with blood sera of healthy persons. Moreover, the fraction of 12-15 kDa protein components was usually increased in blood sera of the patients. At the same time, strong inhibition of the enzyme occurred after addition of blood sera which did not contain the protein fraction. The data obtained suggest that both these patterns--the degree of blood sera inhibitory effect on Na+,K+-ATPase activity and content of 12-15 kDa protein components in blood serum--should be considered as diagnostically valuable at early steps of development of hypertension.
Rogaeva
E A
EA
Perova
N V
NV
Aleksandrov
A A
AA
Oganov
R G
RG
Lopina
O D
OD
D000328:Adult; D001798:Blood Proteins / Q000302:isolation & purification*; D002298:Cardenolides; D004077:Digoxin; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors* / Q000097:blood
D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase
Sushchestvuet li sviaz' mezhdu prisutstviem v syvorotke krovi bol'nykh arterial'noĭ gipertenzieĭ belkovogo komponenta s Mr 15 kD i ingibiruiushchim deĭstviem syvorotki na Na,K-ATFazu?