Conditioned enhancement of natural killer cell activity, but not interferon, with camphor or saccharin-LiCl conditioned stimulus.
Pavlovian conditioning of the natural killer (NK) cell response has been demonstrated by pairing camphor with polyinosinic:polycytidylic acid (poly I:C) in nine association trials. The NK cell response could be conditioned also by using combined saccharin and lithium chloride (LiCl) as the conditioned stimulus. The camphor and saccharin-LiCl paradigms were tested to determine if the conditioned NK cell activity was the result of conditioning of the interferon response. Interferon levels were measured at 6 hr and NK cell activity at 24 hr after application of the conditioned stimulus. The interferon levels measured in separate experiments were not uniformly elevated in conditioned animals compared with controls.
Ghanta
V K
VK
Department of Biology, University of Alabama, Birmingham 35294.
Hiramoto
N S
NS
Solvason
H B
HB
Tyring
S K
SK
Spector
N H
NH
Hiramoto
R N
RN
D000818:Animals; D002164:Camphor / Q000494:pharmacology*; D002712:Chlorides / Q000494:pharmacology*; D003214:Conditioning, Classical; D005260:Female; D007370:Interferon Type I / Q000502:physiology*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000502:physiology*; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D051379:Mice; D008807:Mice, Inbred BALB C; D011070:Poly I-C / Q000494:pharmacology*; D012439:Saccharin / Q000494:pharmacology*
D002712:Chlorides; D007370:Interferon Type I; D002164:Camphor; D008094:Lithium; D012439:Saccharin; D018021:Lithium Chloride; D011070:Poly I-C