Dosimetry of a new holding device for fast d (14) + Be-neutron irradiation of human xenografts in nude mice.
Fast neutron irradiation of human xenografts in the flanks of nude mice is mainly a technical problem. The feasibility is dependent on the distribution of the tumor absorbed dose DT and on an effective shielding of the bodies of the animals. Therefore a special holding device for simultaneous irradiation of two tumour-bearing animals was developed. Meticulous dosimetric investigations using TLD-300 detectors in a mouse phantom showed that a relatively homogeneous dose distribution could be achieved in the xenografts and that effective shielding of the mice from direct irradiation would be achieved; the dose for the bodies of the animals being less than 10% of the dose to the tumour. Thus survival and a sufficient follow-up period of the irradiated animals could be guaranteed for all preclinical dose ranges used.
Budach
V
V
Department of Radiooncology, University of Essen, F.R.G.
Olthoff-Münter
K
K
Frank
H U
HU
Tessler
H
H
D000818:Animals; D005214:Fast Neutrons; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008961:Models, Structural; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000532:radiotherapy*; D009502:Neutrons; D011835:Radiation Protection / Q000295:instrumentation; D011879:Radiotherapy Dosage; D012149:Restraint, Physical / Q000295:instrumentation*; D014183:Transplantation, Heterologous