title: Hormonal changes during decompression sickness.
abstract: Changes in plasma hormone levels were studied in anesthetized dogs during decompression sickness. Hormone levels were measured in 4 groups: control (no dive, n = 9); air group (air dive, ventilated with air postdive, n = 6); helium-oxygen (He-O2) group (air dive, ventilation changed to He-O2 at 30 min postdive, n = 9); nonsurvivor group (air dive, died within 30 min postdive, n = 9). Dived animals were subjected to repetitive dives until pulmonary artery pressure doubled. Plasma epinephrine (Epi) and norepinephrine (NE) concentrations rapidly increased postdive in all animals. Serum angiotensin-converting enzyme (ACE) activity increased postdive in the He-O2 group only, and these increases were small. Diving did not alter serum concentrations of cortisol, thyroxine (T4), or triiodothyronine (T3); however, T4 and T3 fell in all animals, probably as a consequence of anesthesia. He-O2 breathing did not affect concentrations of Epi, NE, cortisol, T4, T3, or serum ACE activity.
authors.forename: P W
authors.initials: PW
authors.lastname: Catron
authors.forename: L B
authors.initials: LB
authors.lastname: Thomas
authors.forename: J J
authors.initials: JJ
authors.lastname: McDermott
authors.forename: R C
authors.initials: RC
authors.lastname: Smallridge
authors.forename: C R
authors.initials: CR
authors.lastname: Lake
authors.forename: C
authors.initials: C
authors.lastname: Kinzer
authors.forename: B
authors.initials: B
authors.lastname: Chernow
authors.forename: E T
authors.initials: ET
authors.lastname: Flynn
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001831:Body Temperature; D002395:Catecholamines / Q000097:blood*; D003665:Decompression Sickness / Q000097:blood*; D004285:Dogs; D006371:Helium; D006728:Hormones / Q000097:blood*; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010100:Oxygen; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood; D013997:Time Factors
chemical_list: D002395:Catecholamines; D006728:Hormones; D013963:Thyroid Hormones; D006371:Helium; D007703:Peptidyl-Dipeptidase A; D010100:Oxygen; D006854:Hydrocortisone