Toxicity trial of prophylactic 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine (ganciclovir) after marrow transplantation in dogs.
The effects of 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine, or ganciclovir, administered during the immediate posttransplant period to dogs given total-body irradiation and autologous marrow transplants were studied. Doses of ganciclovir of 3.0 mg/kg (body weight) per day were well tolerated without detectable delay in hematopoietic recovery, whereas doses of 5.0 mg/kg per day were associated with delayed platelet recovery.
Appelbaum
F R
FR
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
Meyers
J D
JD
Deeg
H J
HJ
Graham
T
T
Schuening
F
F
Storb
R
R
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use / Q000633:toxicity*; D016026:Bone Marrow Transplantation; D003524:Cyclosporins / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000517:prevention & control*; D004285:Dogs; D015774:Ganciclovir; D007165:Immunosuppression Therapy; D010976:Platelet Count / Q000187:drug effects
D000998:Antiviral Agents; D003524:Cyclosporins; D015774:Ganciclovir; D000212:Acyclovir