[Changes in the cyclic nucleotide level and lysosomal enzyme activity in the gastric mucosa of rats with experimental ulcer formation].
The experiments on rats have proved that ulcerative lesions in the gastric mucosa influenced by intraperitoneal catecholamines (noradrenaline and adrenaline) develop on the background of pronounced decrease of cAMP level in the gastric mucosa during ulceration and relatively slight fluctuations of cGMP level. As a result, cAMP/cGMP ratio in mucosa was significantly decreased during ulceration. These changes in cAMP level and cAMP/cGMP ratio may play an important role in destabilization of lysosomal membranes followed by a chain of pathological reactions resulting in ulcerative lesions of the gastric mucosa.
Loginov
A S
AS
Belostotskiĭ
N I
NI
Amirov
N Sh
NSh
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004837:Epinephrine / Q000633:toxicity; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009638:Norepinephrine / Q000633:toxicity; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism*; D013997:Time Factors
D000242:Cyclic AMP; D006152:Cyclic GMP; D009638:Norepinephrine; D004837:Epinephrine
Izmeneniia urovnia tsiklicheskikh nukleotidov i aktivnosti lizosomnykh fermentov v slizistoĭ obolochke zheludka krys pri éksperimental'nom iazvoobrazovanii.