Separation of enantiomeric acids using immobilized acetylquinine as a chiral stationary phase.
Acetylquinine chemically bonded to silica was used as a chiral selector in reversed-phase chromatography for the separation of enantiomers of carboxylic acids and amino acid derivatives, e.g., 2-(4-bromophenoxy)propionic acid, warfarin and N-benzoxycarbonylphenylalanine. An organic modifier (methanol) could be used to regulate the retention without significant influence on the stereoselectivity.
Pettersson
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Department of Analytical Pharmaceutical Chemistry, University of Uppsala, Sweden.
Gioeli
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D000596:Amino Acids / Q000302:isolation & purification*; D002021:Buffers; D002264:Carboxylic Acids / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D000432:Methanol; D011803:Quinine / Q000031:analogs & derivatives; D012822:Silicon Dioxide; D013237:Stereoisomerism
D000596:Amino Acids; D002021:Buffers; D002264:Carboxylic Acids; D007202:Indicators and Reagents; C053728:acetylquinine; D012822:Silicon Dioxide; D011803:Quinine; D000432:Methanol