[Dynamics of urinary excretion of cyclic nucleotides in cancer patients during a long-term follow-up].
Levels of urine excretion of cAMP and cGMP and their ratio were studied in patients with colorectal cancer in the course of a 3-year follow-up. At 12-36 months after surgery, the cAMP/cGMP ratio was higher (mainly due to decreased cGMP level) in disease-free patients than in those with recurrence or metastases. Preoperative level of cyclic nucleotide excretion cannot serve as prognostic factor for recurrence or metastasis development whereas levels of cAMP and cGMP measured within a follow-up period may be used for monitoring the course of colorectal cancer. The cAMP/cGMP ratio tended to rise in application of drugs controlling hyperlipidemia and other signs of cancrophilia.
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D000328:Adult; D003110:Colonic Neoplasms / Q000473:pathology / Q000601:surgery / Q000652:urine*; D000242:Cyclic AMP / Q000652:urine*; D006152:Cyclic GMP / Q000652:urine*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery / Q000652:urine*; D013997:Time Factors
D000242:Cyclic AMP; D006152:Cyclic GMP
Dinamika vyvedeniia tsiklicheskikh nukleotidov s mochoĭ u onkologicheskikh bol'nykh v protsesse dlitel'nogo nabliudeniia.