title: Malignant mixed germ-cell-sex cord-stromal tumors of the ovary associated with isosexual precocious puberty.
abstract: Two cases of hormonally active, metastasizing malignant mixed germ cell-sex cord-stromal tumors are described in otherwise normal prepubertal girls. Isosexual precocity was noted 5 months and 1 month before surgery. One child died 1 year after presentation, and the other was alive, with no apparent tumor, 1 year after diagnosis. These two cases represent the first recorded instance of a unique tumor in which metastases of several cell types were encountered.
authors.affiliation: Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: A G
authors.initials: AG
authors.lastname: Lacson
authors.forename: D A
authors.initials: DA
authors.lastname: Gillis
authors.forename: A
authors.initials: A
authors.lastname: Shawwa
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology; D011629:Puberty, Precocious / Q000209:etiology*