A human tRNA(iMet) gene produces multiple transcripts.
A third nonallelic locus of the human methionyl-tRNA multigene family (tRNA(iMet-3) was isolated. This gene, unlike two other tRNA(iMet) loci, lacks a remarkable run of T and C residues which functions as a termination of transcription signal. Instead, three tandem termination signals, each containing no more than four thymidylate residues, function as relatively inefficient termination signals. As a result, polymerase readthrough generates at least three transcripts in vitro. The efficiency of apparent termination varies significantly at these sites. All resulting transcripts appear to be processed in vitro.
Vnencak-Jones
C L
CL
Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
Wahab
S Z
SZ
Zehner
Z E
ZE
Holmes
W M
WM
D001483:Base Sequence; D004262:DNA Restriction Enzymes; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D012323:RNA Processing, Post-Transcriptional; D012345:RNA, Transfer, Amino Acid-Specific / Q000235:genetics*; D012358:RNA, Transfer, Met / Q000235:genetics*; D014158:Transcription, Genetic
D012345:RNA, Transfer, Amino Acid-Specific; D012358:RNA, Transfer, Met; D004262:DNA Restriction Enzymes