title: [Paraneoplastic limbic encephalopathy, inappropriate ADH secretion and recurrent subclinical epileptic seizures. Clinical, anatomo-pathological and metabolic correlations by positron emission tomography].
abstract: We report a case of limbic encephalopathy clinically characterized by a progressive amnestic syndrome and many EEG seizures mainly localized on the left temporal area. Biological investigations revealed diabetes mellitus and a syndrome of inappropriate antidiuretic hormone secretion (IADH). Haemodynamic and metabolic studies by positron-emission tomography showed an important increase in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen on the left anterior temporal region precisely where the electrical seizures were recorded. Nine months later, severe disorders of memory and a dramatic decrease in CBF and CMRO2 on the same area region were present. At autopsy, a small size oat cell bronchial carcinoma was found with metastases in two small adjacent lymph nodes. Neuropathological examination showed atrophy (neuronal loss, protoplasmic gliosis) in the amygdala; where there was in addition an area of nodular gliosis. The hippocampus and parahippocampal gyrus lesions were severe on the left and moderate on the right side. The authors discuss the nosology of their case in the paraneoplastic syndromes and, with a review of the literature, the role of ADH and cellular hyperactivity in the pathogenesis of specifically localized neuronal alterations.
authors.affiliation: Université de Liège. Clinique neurologique, Belgique.
authors.forename: G
authors.initials: G
authors.lastname: Franck
authors.forename: B
authors.initials: B
authors.lastname: Sadzot
authors.forename: E
authors.initials: E
authors.lastname: Salmon
authors.forename: M
authors.initials: M
authors.lastname: Reznik
authors.forename: M
authors.initials: M
authors.lastname: van der Linden
authors.forename: S
authors.initials: S
authors.lastname: Schmidt
authors.forename: P
authors.initials: P
authors.lastname: Maquet
mesh_terms: D000647:Amnesia / Q000209:etiology; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001927:Brain Diseases / Q000150:complications*; D001984:Bronchial Neoplasms / Q000175:diagnosis; D018288:Carcinoma, Small Cell / Q000175:diagnosis; D002560:Cerebrovascular Circulation; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000209:etiology*; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000209:etiology*; D008032:Limbic System; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism; D010257:Paraneoplastic Syndromes / Q000150:complications*; D014055:Tomography, Emission-Computed
chemical_list: D010100:Oxygen
vernacular_title: Encéphalopathie limbique paranéoplasique, secrétion inappropriée d'ADH et crises épileptiques subintrantes infracliniques. Corrélations cliniques, anatomo-pathologiques et métaboliques par tomographie à émission de positons.