title: Hepatic phosphatidylcholine synthesis in deficiency of lysine and threonine: effect of malathion.
abstract: Rats fed on a rice diet deficient in lysine and threonine showed increased activities of CDP-Choline pathway enzymes and incorporation of (methyl-3H)-choline into hepatic microsomal phosphatidylcholine, compared to rats fed on the same diet supplemented with lysine and threonine. However, the amount of microsomal phosphatidylcholine was significantly decreased in rats fed a deficient rice diet. These results suggest an enhanced phosphatidylcholine catabolism in rats fed on a rice diet deficient in lysine and threonine. Malathion administration reduced the amount of phosphatidylcholine in all the groups.
authors.affiliation: Department of Biochemistry, V.P. Chest Institute, University of Delhi, India.
authors.forename: Y
authors.initials: Y
authors.lastname: Singh
authors.forename: V K
authors.initials: VK
authors.lastname: Chaudhary
authors.forename: S R
authors.initials: SR
authors.lastname: Tyagi
authors.forename: R
authors.initials: R
authors.lastname: Bhatnagar
authors.forename: U K
authors.initials: UK
authors.lastname: Misra
mesh_terms: D000818:Animals; D002797:Choline Kinase / Q000378:metabolism; D019916:Choline-Phosphate Cytidylyltransferase; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008239:Lysine / Q000172:deficiency*; D008294:Malathion / Q000494:pharmacology*; D008297:Male; D009713:Nucleotidyltransferases / Q000378:metabolism; D010713:Phosphatidylcholines / Q000096:biosynthesis*; D051381:Rats; D013912:Threonine / Q000172:deficiency*
chemical_list: D010713:Phosphatidylcholines; D013912:Threonine; D002797:Choline Kinase; D009713:Nucleotidyltransferases; D019916:Choline-Phosphate Cytidylyltransferase; D008239:Lysine; D008294:Malathion