Adrenocortical hormone concentrations in children during cardiopulmonary bypass with and without pulsatile flow.
Plasma cortisol and ACTH concentrations were measured in two groups of children (aged 1-16 yr). Ten children underwent routine (non-pulsatile) cardiopulmonary bypass and 10 underwent pulsatile bypass under moderate hypothermia (28-32 degrees C). Comparable increases in cortisol and ACTH concentrations were demonstrated at the onset of bypass and the concentrations of both hormones increased during bypass. In the post-bypass period plasma cortisol concentration increased sharply; there was no further increase in the plasma ACTH concentration. By 24 h the concentrations of both hormones had declined towards baseline values. There were no significant differences between the groups.
Pollock
E M
EM
(Department of Anaesthesia), Royal Hospital for Sick Children, Yorkhill, Glasgow.
Pollock
J C
JC
Jamieson
M P
MP
Beastall
G S
GS
Wright
C
C
Torsney
B
B
McNicol
L R
LR
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D002315:Cardiopulmonary Bypass / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007223:Infant; D011673:Pulsatile Flow; D012212:Rheology; D013997:Time Factors
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone