Propranolol enhances in vitro interleukin 2 receptor expression on human lymphocytes.
Interleukin 2 receptor (IL-2R) expression was assessed, using anti-Tac monoclonal antibody, after incubation of human lymphocytes with the beta-adrenoceptor antagonist propranolol (PRO). One-hour incubation of mononuclear cells (MNC) with PRO resulted in an increase of Tac positive cells. The greatest rise was observed with a PRO concentration of 10(-6) M (29% ring-stained cells compared with 0% in the control group). Cells cultured for 3 days with PRO showed a lower proportion of Tac positive cells (11%). Fifty-one per cent of MNC cultured with PHA for 3 days expressed IL-2R. Addition of PRO to PHA cultures increased IL-2R expression even more (65%). Enhancement of IL-2R expression after only 1 h incubation with PRO may be due to exposure of formerly synthesized receptor, which can be uncovered by some agents such as PRO.
Malec
P
P
1st Department of Internal Medicine, School of Medicine, Lodz, Poland.
Nowak
Z
Z
D000328:Adult; D000954:Antigens, Surface; D006801:Humans; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*; D011971:Receptors, Immunologic / Q000187:drug effects* / Q000276:immunology; D015375:Receptors, Interleukin-2; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7
D000954:Antigens, Surface; D007376:Interleukin-2; D010835:Phytohemagglutinins; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D011433:Propranolol