Survey of nonhuman primates for antibodies reactive with Epstein-Barr virus (EBV) antigens and susceptibility of their lymphocytes for immortalization with EBV.
The susceptibility to transformation with Epstein-Barr virus (EBV) and the prevalence of antibodies reactive to EBV were examined in 43 primate species. In vitro EBV infection was revealed in lymphocytes from Old World monkeys, including patas monkeys and the colobines, as well as in lymphocytes from the apes. Antibodies reactive to EBV-early antigen/viral capsid antigen (EA/VCA) were detected in all the species of Old World monkeys and apes examined and in two out of seven species of New World monkeys.
Ishida
T
T
Department of Anthropology, Faculty of Science, University of Tokyo, Japan.
Yamamoto
K
K
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D000956:Antigens, Viral / Q000096:biosynthesis / Q000276:immunology*; D036022:Capsid Proteins; D002427:Cebidae / Q000276:immunology; D002460:Cell Line; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D002520:Cercopithecidae / Q000276:immunology; D019309:Epstein-Barr Virus Nuclear Antigens; D000882:Haplorhini / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000276:immunology* / Q000502:physiology; D015186:Hominidae / Q000276:immunology; D008214:Lymphocytes / Q000382:microbiology*; D011443:Strepsirhini / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D036022:Capsid Proteins; D019309:Epstein-Barr Virus Nuclear Antigens; C041788:Epstein-Barr viral capsid antigen; C033305:Epstein-Barr virus early antigen