title: Regional lipiodolized chemotherapy for cholangiocarcinoma associated with oral contraceptives.
abstract: We describe a case of cholangiocarcinoma in a young woman, who presented with cholestatic jaundice following oral contraceptive ingestion. Following diagnostic laparotomy she received intra-arterial 'lipiodolized' chemotherapy. Intravenous mitozantrone was given for 2 years and she is asymptomatic, with computed tomographic evidence of tumour response, 27 months after diagnosis. We suggest that this form of treatment is of value for cholangiocarcinoma.
authors.affiliation: Royal Victoria Hospital, Belfast, UK.
authors.forename: J J
authors.initials: JJ
authors.lastname: McAleer
authors.forename: W
authors.initials: W
authors.lastname: Dickey
authors.forename: R
authors.initials: R
authors.lastname: Clarke
authors.forename: G W
authors.initials: GW
authors.lastname: Johnston
authors.forename: M E
authors.initials: ME
authors.lastname: Callender
mesh_terms: D002759:Adenoma, Bile Duct / Q000139:chemically induced / Q000188:drug therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003138:Common Bile Duct Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D003973:Diatrizoate / Q000008:administration & dosage; D003974:Diatrizoate Meglumine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D007459:Iodized Oil / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D008942:Mitoxantrone / Q000627:therapeutic use
chemical_list: D003277:Contraceptives, Oral, Combined; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D007459:Iodized Oil; D004317:Doxorubicin; D008942:Mitoxantrone