title: The spectrum and natural history of common bile duct stenosis in chronic alcohol-induced pancreatitis.
abstract: Sixty patients with chronic alcohol-induced pancreatitis with endoscopic retrograde cholangiopancreatography evidence of common bile duct stenosis were studied to determine the clinical spectrum and natural history of this complication, as well as the indications for biliary bypass. In 17% of patients, common bile duct stenosis (CBDS) was an incidental finding at ERCP, while in the remaining cases pain and jaundice were the predominant symptoms in 35% and 48%, respectively. Biliary drainage was performed in 38% of patients for persistent or recurrent jaundice, cholangitis, and while undergoing pancreatic duct or cyst drainage procedures for pain. The benign nature of CBDS in chronic alcohol-induced pancreatitis (CAIP) in patients without persistent jaundice is emphasized. In particular, no histologically proved cases of secondary biliary cirrhosis were noted. The majority of patients with CBDS due to CAIP may be safely managed without biliary bypass but require close follow-up.
authors.affiliation: Gastrointestinal Clinic, Groote Schuur Hospital, Cape Town, South Africa.
authors.forename: I
authors.initials: I
authors.lastname: Kalvaria
authors.forename: P C
authors.initials: PC
authors.lastname: Bornman
authors.forename: I N
authors.initials: IN
authors.lastname: Marks
authors.forename: A H
authors.initials: AH
authors.lastname: Girdwood
authors.forename: L
authors.initials: L
authors.lastname: Bank
authors.forename: R E
authors.initials: RE
authors.lastname: Kottler
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications*; D000469:Alkaline Phosphatase / Q000097:blood; D002779:Cholestasis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D002908:Chronic Disease; D003135:Common Bile Duct / Q000000981:diagnostic imaging; D003137:Common Bile Duct Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications* / Q000209:etiology; D011859:Radiography
chemical_list: D000469:Alkaline Phosphatase