[Close relation between fetal thymidine kinase and thymidylate kinase activities in breast cancer].
In human breast cancers, assays on thymidine kinase activity revealed the synthesis of large amounts of d-TTP. This fact suggested the presence of thymidylate kinase closely associated with thymidine kinase. Results obtained with experimental tumors were quite different. These tumors appeared inadequate for the study on thymidine metabolism in mammary cancers.
Madec
A
A
Centre régional de Recherche en Endocrinologie, Faculté de Médecine-Pharmacie, Rennes.
Maquaire
E
E
Javre
J L
JL
Amoros
M
M
Samperez
S
S
Jouan
P
P
D000818:Animals; D001943:Breast Neoplasms / Q000201:enzymology*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D007700:Kinetics; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology*; D009703:Nucleoside-Phosphate Kinase / Q000378:metabolism*; D010770:Phosphotransferases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013937:Thymidine Kinase / Q000378:metabolism*
D007527:Isoenzymes; D010770:Phosphotransferases; D013937:Thymidine Kinase; D009703:Nucleoside-Phosphate Kinase; C020093:dTMP kinase
Relation étroite entre les activités de la thymidine kinase foetale et de la thymidylate kinase dans les cancers du sein.