title: In vitro antiviral activity of dammar resin triterpenoids.
abstract: Nine triterpenes with antiviral activity against Herpes simplex virus types I and II in vitro were isolated from dammar resin. Each compound caused a significant reduction in viral cytopathic effect when Vero cells were exposed continuously to 1-10 micrograms/ml of compound for 48 h after viral challenge. The triterpenes were identified as dammaradienol [1], dammarenediol-II [2], hydroxydammarenone-I [3], ursonic acid [5], hydroxyhopanone [11], dammarenolic acid [15], shoreic acid [16], eichlerianic acid [17], and a novel compound, hydroxyoleanonic lactone [7], on the basis of their chromatographic, spectroscopic, and physical properties.
authors.affiliation: Research and Development Division, Smith, Kline and French Laboratories, Philadelphia, Pennsylvania 19101.
authors.forename: B L
authors.initials: BL
authors.lastname: Poehland
authors.forename: B K
authors.initials: BK
authors.lastname: Carté
authors.forename: T A
authors.initials: TA
authors.lastname: Francis
authors.forename: L J
authors.initials: LJ
authors.lastname: Hyland
authors.forename: H S
authors.initials: HS
authors.lastname: Allaudeen
authors.forename: N
authors.initials: N
authors.lastname: Troupe
mesh_terms: D000998:Antiviral Agents; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000032:analysis*; D012116:Resins, Plant / Q000032:analysis; D018139:Simplexvirus / Q000187:drug effects; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D012116:Resins, Plant; D014315:Triterpenes