Importance of the projection from the sensory to the motor cortex for recovery of motor function following partial thalamic lesion in the monkey.
Motor deficits produced by thalamic lesions were studied using adult cynomolgus monkeys. Lesioned areas included n. ventralis anterior (VA), ventralis lateralis (VL), n. ventralis posterolateralis pars oralis (VPLo), pars caudalis (VPLc) n. subthalamus (STN) and n. centrum medianum (CM). When the lesion included VA, VL and VPLo, there was a cerebellar syndrome, i.e., ataxia and dysmetria. When the lesion included VPLo and VPLc, the animal was paralyzed. When the lesion included VPLo and rostral part of VPLc, there was loss of orientation in hand movement and clumsiness of finger manipulation. These motor deficits gradually disappeared within 1-2 weeks and the function recovered near to normal except for when VPLo and VPLc were totally destroyed. After recovery of motor function, the somatic sensory cortex (areas 1, 2, 3b) ipsilateral to the thalamic lesion was removed. Removal of the sensory cortex resulted in abolition of the recovered function, but when the border area between VPLo and VPLc was intact, the function recovered again. On the other hand, when the thalamic lesion included this border area, succeeding cortical lesion permanently abolished the recovered function or the reappeared function was substantially worse than that before the cortical lesion. Neuronal mechanisms subserving these differences are discussed and it is concluded that when direct sensory input to the motor cortex was interrupted by lesion of the border area between VPLo and VPLc, the lost function was compensated by reorganization of the projection from the sensory cortex to the motor cortex.
Bornschlegl
M
M
Rockefeller University, New York, NY 10021.
Asanuma
H
H
D000818:Animals; D005260:Female; D007608:Kainic Acid; D008252:Macaca fascicularis; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement; D010296:Parietal Lobe / Q000502:physiology*; D013003:Somatosensory Cortex / Q000502:physiology*; D009435:Synaptic Transmission; D013787:Thalamic Nuclei / Q000502:physiology*
D007608:Kainic Acid