Is multiple sclerosis the equivalent of Parkinson's disease for noradrenaline?
We have found that increasing noradrenaline (NA) levels through the use of antidepressants and 1-dopa has effects on the symptoms of MS. On these grounds we wish to present a hypothetical basis of multiple sclerosis and discuss support found in the literature. The hypothesis is that in MS there is a deficiency of NA in the synapses of the nervous system and an interruption of impulse transmission. An interruption of sufficient intensity and duration will lead to axon damage and secondary demyelination.
Berne-Fromell
K
K
Arnica Sjukård AB, Linköping, Sweden.
Fromell
H
H
Lundkvist
S
S
Lundkvist
P
P
D003711:Demyelinating Diseases / Q000209:etiology; D006801:Humans; D009103:Multiple Sclerosis / Q000209:etiology*; D009638:Norepinephrine / Q000172:deficiency*; D010300:Parkinson Disease; D005082:Physical Exertion; D013569:Synapses / Q000378:metabolism; D009435:Synaptic Transmission
D009638:Norepinephrine