title: Adenovirus infections and respiratory illnesses in children in group day care.
abstract: Adenovirus infections and respiratory illnesses among 123 children attending a research day care center were analyzed from data collected prospectively from 1967 through 1981. During the 15-year study period, 298 adenovirus isolates were recovered from respiratory secretions of the study children, and five different serotypes were identified, with types 1, 2, and 5 accounting for 92% of the typed isolates. Annual incidence of each serotype varied greatly, with types 2 and 5 predominating before 1975 and type 1 thereafter. Exposure to adenovirus in the day care center correlated with acquisition of infection. Through two years of age, children were exposed to 3.4 +/- 0.9 (mean +/- SD) different serotypes and became infected by 2.1 +/- 0.8 different types. Most infections occurred before the child's second birthday, and incidence was highest from six to 12 months of age (1.4 primary infections/child-year). Mild and febrile illness accompanied 75% of primary isolations. Otitis media occurred in 37% of illnesses over all ages and in greater than 50% of illnesses among infants.
authors.affiliation: Department of Pediatrics, University of North Carolina at Chapel Hill.
authors.forename: D L
authors.initials: DL
authors.lastname: Pacini
authors.forename: A M
authors.initials: AM
authors.lastname: Collier
authors.forename: F W
authors.initials: FW
authors.lastname: Henderson
mesh_terms: D000257:Adenoviridae Infections / Q000453:epidemiology*; D000258:Adenovirus Infections, Human / Q000453:epidemiology* / Q000635:transmission; D000260:Adenoviruses, Human / Q000145:classification / Q000302:isolation & purification; D000367:Age Factors; D002656:Child Day Care Centers; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D009657:North Carolina; D011446:Prospective Studies; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000635:transmission