Nerve growth factor is a neurotrophic factor for forebrain cholinergic neurons; implications for Alzheimer's disease.
Findings obtained in recent years provide strong evidence that nerve growth factor (NGF) acts as a neurotrophic factor for cholinergic neurons of the mammalian forebrain. NFG receptors are exclusively localized on these neurons in the rat and human forebrain. NGF promotes survival, fiber elongation and expression of transmitter-specific enzymes of forebrain cholinergic neurons, in vivo and in vitro. In adult rats, intraventricular injections of NGF attenuate the degeneration of these cells after experimental lesions. These findings suggest that NGF might be able to attenuate the degeneration of cholinergic neurons occurring in Alzheimer's disease.
Hefti
F
F
Department of Neurology, University of Miami School of Medicine, Florida.
Will
B
B
D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D002799:Cholinergic Fibers / Q000187:drug effects*; D006801:Humans; D009414:Nerve Growth Factors / Q000494:pharmacology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000302:isolation & purification; D017475:Receptors, Nerve Growth Factor
D009414:Nerve Growth Factors; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor