title: Protective effect of the F(ab')2 fragments of monoclonal antibodies to mouse hepatitis virus.
abstract: The F(ab')2 fragments were prepared from three monoclonal antibodies (MAbs) reactive with either peplomer glycoprotein (E2) or nucleocapsid protein (NP) of a low-virulence mouse hepatitis virus (MHV), MHV-NuU. All the three MAbs could protect mice from challenge infection with virulent MHV-2, whereas only one of the anti-E2 MAbs was capable of neutralizing the virus in vitro. The F(ab')2 fragment of neutralizing anti-E2 MAb was shown to protect mice from challenge infection, but those of non-neutralizing anti-E2 and anti-NP MAbs were not protective.
authors.affiliation: Department of Animal Pathology, University of Tokyo.
authors.forename: K
authors.initials: K
authors.lastname: Nakanaga
authors.forename: K
authors.initials: K
authors.lastname: Yamanouchi
authors.forename: K
authors.initials: K
authors.lastname: Fujiwara
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology*; D002213:Capsid / Q000276:immunology; D005260:Female; D006524:Hepatitis, Viral, Animal / Q000276:immunology / Q000517:prevention & control*; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D006517:Murine hepatitis virus / Q000276:immunology*; D009500:Neutralization Tests; D014758:Viral Core Proteins / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology; D015678:Viral Structural Proteins
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D007140:Immunoglobulin Fab Fragments; D014758:Viral Core Proteins; D014764:Viral Proteins; D015678:Viral Structural Proteins