Radiation dosimetry of iodine-123 HEAT, an alpha-1 receptor imaging agent.
Biologic distribution data in the rat were obtained for the alpha-1 adrenoceptor imaging agent (+/-) 2-[beta-(iodo-4-hydroxyphenyl)ethylaminomethyl]tetralone (HEAT) labeled with [125I]. The major excretory routes were through the liver (67%) and the kidney (33%). Internal radiation absorbed dose estimates to nine source organs, total body, the GI tract, gonads, and red bone marrow were calculated for the human using the physical decay data for [123I]. The critical organ was found to be the lower large intestine, receiving 1.1 rad per mCi of [123I]HEAT administered. The total-body dose was found to be 58 mrad per mCi.
Thomas
K D
KD
Veterans Administration Medical Center, Gainesville, Florida 32602.
Greer
D M
DM
Couch
M W
MW
Williams
C M
CM
D000328:Adult; D000818:Animals; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D010627:Phenethylamines / Q000378:metabolism*; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000000981:diagnostic imaging*; D044024:Tetralones; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D010627:Phenethylamines; D011942:Receptors, Adrenergic, alpha; D044024:Tetralones; C048008:2-(beta-(3-iodo-4-hydroxyphenyl)ethylaminomethyl)tetralone