Toxicity and metabolism of a new insect repellent N,N-diethylphenylacetamide in mice, rats and guinea pigs on cutaneous application.
Cutaneous LD50 of N,N-diethylphenylacetamide (DEPA), a new multi insect repellent was 2200, 3200 and 7100 mg/kg body weight in female mice, rats and guinea pigs; and 1600 and 4000 mg/kg in male mice and rats indicating a high degree of safety on skin contact. Dermal application of DEPA to young growing rats for 21 days at a dose of 50 mg/kg did not exert any adverse effects while massive doses of 500 and 1000 mg/kg caused marked reduction of body weight gain and lowering of activities of serum alanine aminotransferase, aspartate aminotransferase and cholinesterase. Along with DEPA, N-ethylphenylacetamide, phenylacetamide and phenylacetic acid were detected in the urine of DEPA treated mice, rats and guinea pigs.
Rao
S S
SS
Defence Research and Development Establishment, Gwalio, India.
Swamy
R V
RV
Ramachandran
P K
PK
D000081:Acetamides / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D000083:Acetanilides / Q000652:urine; D000287:Administration, Topical; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002802:Cholinesterases / Q000097:blood; D005260:Female; D006168:Guinea Pigs; D007302:Insect Repellents / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008956:Models, Chemical; D051381:Rats
D000081:Acetamides; D000083:Acetanilides; D007302:Insect Repellents; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002802:Cholinesterases; C044250:N,N-diethylphenylacetamide