Action of hypochlorous acid on the antioxidant protective enzymes superoxide dismutase, catalase and glutathione peroxidase.
The neutrophil enzyme myeloperoxidase generates hypochlorous acid (HOCl) at sites of inflammation. Glutathione peroxidase is very quickly inactivated by low concentration of HOCl. Inactivation of catalase is also rapid, but requires higher HOCl concentrations and the haem appears to be degraded. Inactivation of bovine CuZn superoxide dismutase is slower. Hence superoxide dismutase should not be easily inactivated by HOCl at sites of inflammation, which may contribute to its effectiveness as an anti-inflammatory agent and in minimizing reperfusion injury.
Aruoma
O I
OI
Department of Biochemistry, University of London King's College, Strand Campus, U.K.
Halliwell
B
B
D001798:Blood Proteins / Q000494:pharmacology; D002374:Catalase / Q000037:antagonists & inhibitors*; D005979:Glutathione Peroxidase / Q000037:antagonists & inhibitors*; D006997:Hypochlorous Acid / Q000494:pharmacology*; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors*; D000515:alpha 1-Antitrypsin
D001798:Blood Proteins; D000515:alpha 1-Antitrypsin; D006997:Hypochlorous Acid; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D010196:Pancreatic Elastase