Comparison of inhibition of erythrocyte pyrimidine 5'-nucleotidase and delta-aminolevulinic acid dehydratase by lead.
The effect of lead on the activities of erythrocyte pyrimidine 5'-nucleotidase (P5N) and delta-aminolevulinic acid dehydratase (ALAD) was investigated in control and lead-exposed workers. The inhibitory effect of lead in vivo and in vitro was more remarkable on the ALAD than on the P5N activity values. It was demonstrated that the pH optimum of both ALAD and P5N in lead workers shifts to the acidic side (nearly pH 6.0) compared to that in control workers.
Tomokuni
K
K
Department of Community Health Science, Saga Medical School, Japan.
Ichiba
M
M
D015720:5'-Nucleotidase; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D007854:Lead / Q000633:toxicity*; D008297:Male; D009708:Nucleotidases / Q000037:antagonists & inhibitors* / Q000097:blood; D000623:Porphobilinogen Synthase / Q000037:antagonists & inhibitors* / Q000097:blood
D007854:Lead; D009708:Nucleotidases; D015720:5'-Nucleotidase; D000623:Porphobilinogen Synthase