title: [The immunohistochemical localization of CA 15-3 in human breasts and their tumors].
abstract: The tissue distribution of CA 15-3, a breast carcinoma associated antigenic determinant, has been investigated by an avidin-biotin immunoperoxidase technique in the human breasts and in their tumors. In cases of scirrhous carcinoma, positive stainings for CA 15-3 were observed in almost all carcinoma cells. In cases of solid-tubular carcinomas and papillotubular carcinomas, the reaction was various and there was no correlation between the distribution of CA 15-3 and the clinical stage. Apical staining was recognized in both solid-tubular and papillotubular carcinomas, in benign breast tumors, and in normal breast tissues. CA 15-3 appears to be related to the degree of differentiation of the breast tissue.
authors.affiliation: Dept. of Obstet. & Gynecol., Kudanzaka Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Sugihara
authors.forename: M
authors.initials: M
authors.lastname: Hatano
authors.forename: A
authors.initials: A
authors.lastname: Kaneko
authors.forename: K
authors.initials: K
authors.lastname: Motoji
authors.forename: M
authors.initials: M
authors.lastname: Nasu
authors.forename: I
authors.initials: I
authors.lastname: Okayasu
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: N
authors.initials: N
authors.lastname: Inaba
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology; D000231:Adenocarcinoma, Papillary / Q000276:immunology; D002293:Adenocarcinoma, Scirrhous / Q000276:immunology; D000232:Adenofibroma / Q000276:immunology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate; D001940:Breast / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged
chemical_list: D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate