T-cell abnormalities in antibody deficiency syndromes.
We studied two patients with hypogammaglobulinaemia, three with selective IgA deficiency, and four with selective extreme IgM deficiency for T-cell abnormalities in the circulating blood. Most patients had altered CD4+ helper/inducer and CD8+ suppressor/cytotoxic T-cell subsets, and an elevated percentage of HLA-DR+ and interleukin 2 (IL-2) receptor+ antigens on lymphocytes. One patient with the selective IgA deficiency had an absence of CD4+ T cells in blood. The lymphocytes of eight patients showed a diminished proliferative response and deficient IL-2 production in response to stimulation with phytohaemagglutinin or concanavalin A. The three patients with selective IgM deficiency were found to have a defective T-cell abnormality in IgM synthesis by B cells. It is interesting that CD8+ T cells of the two patients with IgM deficiency demonstrated suppressor cell function for IgM synthesis by the normal B and T cells.
Raziuddin
S
S
Department of Clinical Immunology, King Saud University, College of Medicine, Abha, Saudi Arabia.
Elawad
M E
ME
Benjamin
B
B
D000361:Agammaglobulinemia / Q000276:immunology*; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004406:Dysgammaglobulinemia / Q000276:immunology*; D006801:Humans; D017098:IgA Deficiency; D007075:Immunoglobulin M / Q000172:deficiency*; D007376:Interleukin-2 / Q000096:biosynthesis; D010835:Phytohemagglutinins; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D007376:Interleukin-2; D010835:Phytohemagglutinins