title: Granuloma caused by oxidized cellulose following craniotomy.
abstract: Three cases are reported in which large granulomas developed 13 to 21 months respectively after removal of intracranial meningiomas (2 cases) and after operation for an anterior communicating artery aneurysm. In each of the cases oxidized cellulose had been used and left in place for haemostasis. All of the granulomas acted as space-occupying lesions. They could be removed operatively with good result. All of them consisted of mononuclear phagocytic and multi-nuclear giant cells and contained remnants of oxidized cellulose. No comparable cases have been reported in the literature. Diagnosis, treatment and possible aetiological factors are discussed.
authors.affiliation: Department of Neurosurgery, School of Medicine, Kanazawa University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Onishi
authors.forename: K
authors.initials: K
authors.lastname: Shoin
authors.forename: H
authors.initials: H
authors.lastname: Nagatani
mesh_terms: D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology; D002482:Cellulose / Q000031:analogs & derivatives*; D002483:Cellulose, Oxidized / Q000009:adverse effects*; D005260:Female; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D008579:Meningioma / Q000000981:diagnostic imaging / Q000601:surgery*; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D002483:Cellulose, Oxidized; D002482:Cellulose