Does the blockade of opioid receptors influence the development of ethanol dependence?
We have tested whether the opioid antagonists naloxone (2 mg/kg), naltrexone (2 mg/kg) and diprenorphine (0.2 mg/kg), and the agonist morphine (4-8 mg/kg) given subcutaneously (10 min before ethanol for 7 days) modify the ethanol withdrawal syndrome (audiogenic seizures) following chronic ethanol intoxication in rats. We found that naloxone, naltrexone and diprenorphine modified the ethanol withdrawal syndrome. These findings do not rule out the possibility of a biochemical link between the action of ethanol and opiates at the level of opioid receptors.
Kotlińska
J
J
Department of Pharmacodynamics, Medical Academy, Lublin, Poland.
Langwiński
R
R
D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D004174:Diprenorphine / Q000494:pharmacology; D005260:Female; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects* / Q000502:physiology; D012640:Seizures / Q000503:physiopathology; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology
D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D004174:Diprenorphine; D009270:Naloxone; D009271:Naltrexone; D009020:Morphine