title: Cocaine: long-term administration depletes cardiac enzymes in the rat.
abstract: Arterioles and myocytes of the cardiac ventricle were examined histochemically to determine their metabolic profiles in normal rats and in rats treated either acutely or chronically with cocaine. Following long-term, but not acute, cocaine administration, enzymes involved in both aerobic and anaerobic metabolism as well as in hexosemonophosphate shunt were greatly decreased. These data suggest that long-term usage of cocaine leads to severely impaired coronary metabolism.
authors.forename: M E
authors.initials: ME
authors.lastname: Trulson
authors.forename: L R
authors.initials: LR
authors.lastname: Epps
authors.forename: J C
authors.initials: JC
authors.lastname: Joe
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003331:Coronary Vessels / Q000187:drug effects* / Q000201:enzymology; D003576:Electron Transport Complex IV / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D006651:Histocytochemistry; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D009243:NAD / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D009243:NAD; D010088:Oxidoreductases; D003576:Electron Transport Complex IV; D000251:Adenosine Triphosphatases; D003042:Cocaine