Hemolytic uremic syndrome in a patient with small cell lung cancer.
Hemolytic uremic syndrome is a rare entity in patients with carcinoma and presents with a triad of renal insufficiency, microangiopathic hemolytic anemia, and thrombocytopenia. We report this syndrome for the first time in a patient with small cell lung carcinoma. Spontaneous platelet aggregation of washed normal platelets was demonstrated using patient plasma. Circulating immune complex levels were not elevated. The entity completely resolved after treatment with plasma, vincristine, aspirin, and dipyridamole.
Avvento
L
L
Division of Hematology, State University of New York at Stony Brook.
Gordon
S
S
Silberberg
J M
JM
Zarrabi
M H
MH
Zucker
S
S
D018288:Carcinoma, Small Cell / Q000150:complications*; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000150:complications* / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D010975:Platelet Aggregation Inhibitors; D014750:Vincristine