Small bowel transplantation in a child. Morphologic, immunohistochemical, and clinical results.
A small bowel transplant was performed on a five-year-old boy with a short bowel syndrome. The donor was the child's mother. Despite immunosuppressive therapy, the transplant was acutely rejected and had to be explanted on the twelfth day. Morphologic and immunohistochemical investigations on subsequent biopsies taken from the small bowel transplant were carried out. Besides typical changes in epithelial cells and the presence of T-cell infiltrates and Ig-deposits in vessels, many macrophages were seen. The submucosa in particular was invaded before rejection by numerous macrophages with positive results of antimonocyte/macrophage antibodies Ki-M6 and Ki-M7. The number of the macrophage antibodies Ki-M6 and Ki-M7. The number of the monocyte/macrophage cells and the immunohistochemical characteristics of the same may be important parameters for monitoring small bowel transplantations.
Hansmann
M L
ML
Department of Pathology University of Kiel, Federal Republic of Germany.
Deltz
E
E
Gundlach
M
M
Schroeder
P
P
Radzun
H J
HJ
D002675:Child, Preschool; D004848:Epithelium / Q000473:pathology; D006084:Graft Rejection; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007150:Immunohistochemistry; D007421:Intestine, Small / Q000473:pathology / Q000637:transplantation*; D008264:Macrophages / Q000473:pathology; D008286:Malabsorption Syndromes / Q000601:surgery*; D008297:Male; D012778:Short Bowel Syndrome / Q000473:pathology / Q000601:surgery*; D013601:T-Lymphocytes / Q000473:pathology
D007074:Immunoglobulin G; D007075:Immunoglobulin M