Effects of denervation on the responses of the rat tail artery to alpha beta-methylene ATP.
1. One microM alpha beta-methylene ATP (alpha beta meATP) caused transient contraction and depolarization of the smooth muscle of the rat tail artery. 2. The peak contraction was greater in denervated arteries; the peak depolarization was the same in normal and denervated arteries. 3. This suggests that alpha beta meATP receptors do not increase following denervation. 4. In denervated arteries electrical stimulation produced depolarizing responses that were not due to neurotransmitter release but which were blocked by alpha beta meATP. 5. It is suggested that alpha beta meATP may be a blocker of cation channels.
Kotecha
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Department of Physiology, Monash University, Clayton, Victoria, Australia.
Neild
T O
TO
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000187:drug effects; D003714:Denervation; D004558:Electric Stimulation; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000378:metabolism*; D014661:Vasoconstriction / Q000187:drug effects*
D017981:Receptors, Neurotransmitter; C005147:5'-adenylyl (beta,gamma-methylene)diphosphonate; D000255:Adenosine Triphosphate; C002630:alpha,beta-methyleneadenosine 5'-triphosphate