Effect of alpha tocopheryl succinate on cyclic AMP-dependent protein kinase activity in murine B-16 melanoma cells in culture.
d-Alpha tocopheryl succinate (vitamin E succinate), which inhibited growth and survival, and induced differentiation in murine B-16 melanoma cells in culture, increased adenosine 3',5'cyclic monophosphate-(cAMP)-dependent protein kinase (PK) activity without increasing the cellular cAMP level. Prostaglandin (PG)A2, which produced changes in melanoma cells similar to those produced by vitamin E succinate, also increased cAMP-dependent PK activity without changing the intracellular level of cAMP.
Torelli
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S
Department of Radiology, College of Medicine, University of Colorado Health Sciences Center, Denver 80262.
Masoudi
F
F
Prasad
K N
KN
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D000242:Cyclic AMP / Q000032:analysis; D008546:Melanoma, Experimental / Q000201:enzymology* / Q000473:pathology; D051379:Mice; D011454:Prostaglandins A / Q000494:pharmacology; D011494:Protein Kinases / Q000032:analysis*; D024505:Tocopherols; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology
D011454:Prostaglandins A; D014810:Vitamin E; D000242:Cyclic AMP; D011494:Protein Kinases; C100008:prostaglandin A2; D024505:Tocopherols