title: [Synthesis and immunogenic properties of peptides corresponding to the 200-210 site of the oncoprotein p28sis].
abstract: Synthesis of peptides corresponding to the 201-210 and 200-206 sequences of p28sis oncoprotein is reported. This region of the oncoprotein was chosen as a probable epitope basing on the analysis of its secondary structure and hydrophilicity profile. The synthesis was carried out by classical method in solution using side-protecting groups of the benzyl type. Conjugates of the peptides with protein carriers and polyclonal antibodies to the peptides were obtained. Antiserum against the 201-210 peptide conjugate is shown to be specific to p28sis oncoprotein and its p56sis dimer.
authors.forename: V V
authors.initials: VV
authors.lastname: Antonenko
authors.forename: I A
authors.initials: IA
authors.lastname: Prudchenko
authors.forename: I I
authors.initials: II
authors.lastname: Mikhaleva
authors.forename: N N
authors.initials: NN
authors.lastname: Mazurenko
authors.forename: F L
authors.initials: FL
authors.lastname: Kiselev
mesh_terms: D000595:Amino Acid Sequence; D002471:Cell Transformation, Neoplastic; D020575:Oncogene Proteins v-sis; D010455:Peptides / Q000138:chemical synthesis* / Q000276:immunology; D012191:Retroviridae Proteins / Q000235:genetics*; D012842:Sarcoma Virus, Woolly Monkey / Q000235:genetics
chemical_list: D020575:Oncogene Proteins v-sis; D010455:Peptides; D012191:Retroviridae Proteins
vernacular_title: Sintez i immunogennye svoĭstva peptidov uchastka 200-210 posledovatel'nosti onkobelka p28sis.