title: Interleukin-1 inhibits follicle stimulating hormone-induced differentiation in rat granulosa cells in vitro.
abstract: Increasing evidence suggests that factors secreted from cells of the immune system can affect endocrine function. In this report we show that the monokine, interleukin-1, inhibits follicle stimulating hormone-induced development of luteinizing hormone receptors and reduces progesterone secreted from cultured rat granulosa cells. These effects of interleukin-1 were observed in the physiological range of 10(-9) M. The ability of sex steroids to influence the immune response together with our results support the hypothesis that there is a bidirectional communication network which links the immune and reproductive endocrine systems.
authors.affiliation: U.S.-Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, Louisisana 70037.
authors.forename: P E
authors.initials: PE
authors.lastname: Gottschall
authors.forename: A
authors.initials: A
authors.lastname: Uehara
authors.forename: S T
authors.initials: ST
authors.lastname: Hoffmann
authors.forename: A
authors.initials: A
authors.lastname: Arimura
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D006107:Granulosa Cells / Q000166:cytology / Q000187:drug effects*; D007375:Interleukin-1 / Q000494:pharmacology*; D011374:Progesterone / Q000378:metabolism; D051381:Rats; D011974:Receptors, LH / Q000096:biosynthesis
chemical_list: D007375:Interleukin-1; D011974:Receptors, LH; D011374:Progesterone; D000324:Adrenocorticotropic Hormone; D005640:Follicle Stimulating Hormone