title: Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus.
abstract: The tyrosine kinase activity of the insulin receptor was investigated in skeletal muscle biopsies from insulin-resistant males with obesity or with Type 2 (non-insulin-dependent) diabetic males who were lean or overweight. The kinase activity of the receptor from all three groups of insulin-resistant subjects was 40% less when compared to the activity of lean control subjects. This alteration was present in the absence of changes in the level of the insulin receptor on its insulin binding characteristics. We conclude that the tyrosine kinase activity of the skeletal muscle insulin receptor is defective in obesity and Type 2 diabetes, and that this alteration contributes to the insulin-resistant characteristics of both disorders.
authors.affiliation: Department of Medicine, Karolinska Institute, Stockholm, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Arner
authors.forename: T
authors.initials: T
authors.lastname: Pollare
authors.forename: H
authors.initials: H
authors.lastname: Lithell
authors.forename: J N
authors.initials: JN
authors.lastname: Livingston
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000201:enzymology; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology*; D006801:Humans; D066298:In Vitro Techniques; D007328:Insulin / Q000097:blood; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000201:enzymology* / Q000378:metabolism; D009765:Obesity / Q000201:enzymology*; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011972:Receptor, Insulin / Q000378:metabolism; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D007328:Insulin; D011505:Protein-Tyrosine Kinases; D011972:Receptor, Insulin