Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes.
The tumor necrosis factor (TNF) alpha and beta gene pair has been linked in the human major histocompatibility complex to HLA-B, HLA-C, and, tentatively, HLA-E and HLA-A on one side and to the class III complement/steroid 21-hydroxylase gene cluster on the other by pulsed-field gel electrophoresis. The TNF genes are located 200 kilobases (kb) centromeric of HLA-B and about 350 kb telomeric of the class III cluster. Together with previous data on the linkage and structures of the class II and class III regions, a restriction map of the entire human major histocompatibility complex of about 3500 kb has been prepared.
Carroll
M C
MC
Department of Pediatrics, Harvard Medical School, Boston, MA 02115.
Katzman
P
P
Alicot
E M
EM
Koller
B H
BH
Geraghty
D E
DE
Orr
H T
HT
Strominger
J L
JL
Spies
T
T
D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D003165:Complement System Proteins / Q000235:genetics*; D004262:DNA Restriction Enzymes; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006681:HLA-D Antigens / Q000235:genetics*; D006801:Humans; D008285:Major Histocompatibility Complex; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D006680:HLA Antigens; D006681:HLA-D Antigens; D014409:Tumor Necrosis Factor-alpha; D003165:Complement System Proteins; D004262:DNA Restriction Enzymes