title: Clinical experience with placental site trophoblastic tumors at the New England Trophoblastic Disease Center.
abstract: From 1982-1986, seven patients with pathologically confirmed placental site trophoblastic tumors underwent treatment at the New England Trophoblastic Disease Center. All seven patients presented with nonmetastatic disease; the presenting symptom was vaginal bleeding in six patients and amenorrhea in one patient. Mitotic counts of the tumor may vary among endometrial curettings, hysterectomy specimens, and metastatic lesions. When placental site trophoblastic tumor is diagnosed on endometrial curettage, a thorough metastatic workup should be undertaken. Because of this tumor's poor response to chemotherapy, a diagnosis of nonmetastatic placental site trophoblastic tumor should be followed by prompt hysterectomy.
authors.affiliation: Department of Obstetrics and Gynecology, Harvard Medical School, Boston, Massachusetts.
authors.forename: N J
authors.initials: NJ
authors.lastname: Finkler
authors.forename: R S
authors.initials: RS
authors.lastname: Berkowitz
authors.forename: S G
authors.initials: SG
authors.lastname: Driscoll
authors.forename: D P
authors.initials: DP
authors.lastname: Goldstein
authors.forename: M R
authors.initials: MR
authors.lastname: Bernstein
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006063:Chorionic Gonadotropin / Q000097:blood; D003131:Combined Modality Therapy; D004107:Dilatation and Curettage; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008207:Lymphatic Metastasis; D009511:New England; D010920:Placenta; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000097:blood / Q000473:pathology / Q000628:therapy*; D014594:Uterine Neoplasms / Q000097:blood / Q000473:pathology / Q000628:therapy*
chemical_list: D006063:Chorionic Gonadotropin