title: [Structural stabilization of lipids and visual pigment rhodopsin in the photoreceptor membrane by vitamin E].
abstract: Interaction of alpha-tocopherol with free fatty acids in bovine retinal photoreceptor membranes was studied using ESR spin-probe technique and measurements of rhodopsin thermal denaturation rates. Exogenous alpha-tocopherol incorporated into photoreceptor membranes prevented thermal destabilization of rhodopsin caused by free fatty acids. The efficiency of the stabilizing action of alpha-tocopherol directly depended both on the chain length and the degree of fatty acid unsaturation.
authors.forename: V A
authors.initials: VA
authors.lastname: Tiurin
authors.forename: S N
authors.initials: SN
authors.lastname: Korol'kov
authors.forename: A L
authors.initials: AL
authors.lastname: Berman
authors.forename: V E
authors.initials: VE
authors.lastname: Kagan
mesh_terms: D000818:Animals; D002417:Cattle; D004347:Drug Interactions; D004578:Electron Spin Resonance Spectroscopy; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D008563:Membrane Lipids / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D010786:Photoreceptor Cells / Q000187:drug effects* / Q000378:metabolism; D012168:Retinal Pigments / Q000378:metabolism*; D012243:Rhodopsin / Q000378:metabolism*; D013113:Spin Labels; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D005230:Fatty Acids, Nonesterified; D008563:Membrane Lipids; D010743:Phospholipids; D012168:Retinal Pigments; D013113:Spin Labels; D014810:Vitamin E; D012243:Rhodopsin
vernacular_title: Strukturnaia stabilizatsiia lipidov i zritel'nogo pigmenta rodopsina v fotoretseptornoĭ membrane vitaminom E.