Monoclonal antibodies against human scirrhous carcinoma of the stomach.
We established three monoclonal antibodies (MoAbs) S43, S74 and S202 which reacted strongly with scirrhous carcinomas of the stomach. MoAb S43 reacted with culture supernatants of the scirrhous gastric cancer cell line MK-01, and thus may be useful for in vivo detection of markers for this tumor. MoAb S74 reacted with the majority of gastric cancer tissues, but showed no reaction with normal tissues. It may be useful as a drug carrier in targeting chemotherapy against scirrhous gastric cancer, because of its tumor specificity. MoAb S202 reacted strongly with 100% of scirrhous gastric cancer samples and with the culture supernatants of colonic and pancreatic cancers.
Yokota
T
T
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Takahashi
T
T
Yamaguchi
T
T
Kitamura
K
K
Masuko
T
T
Hashimoto
Y
Y
D002293:Adenocarcinoma, Scirrhous / Q000276:immunology*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000912:Antibodies, Neoplasm / Q000276:immunology*; D002460:Cell Line; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D051379:Mice; D013274:Stomach Neoplasms / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm