Renal handling of nourseothricin.
Nourseothricin 1 is preferentially excreted via kidney and signs of nephrotoxicity can be observed after its administration. Renal handling of 1 was characterized in experiments on renal cortical slices under various experimental conditions. Following administration in vivo or in vitro the renal tubular transport system for organic anions (p-aminohippurate, PAH) is not influenced by 1. There is a high degree of accumulation of 1 in renal cortical slices. In contrast to PAH accumulation there is no influence of nitrogen atmosphere, simultaneous administration of PAH, probenecid or trishydroxyaminomethane on 1 accumulation. Age dependent differences in 1 accumulation does not exist. Our data show a distinct uptake of 1 in kidney tissue. Accumulation of 1 in renal cortical slices is caused by binding; an active tubular transport of 1 in renal cortical slices could be excluded.
Bräunlich
H
H
Institute of Pharmacology and Toxicology, Friedrich Schiller University Jena.
Hoffmann
H
H
Bocker
H
H
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism*; D007672:Kidney Cortex / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013309:Streptothricins / Q000378:metabolism*; D010130:p-Aminohippuric Acid / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D013309:Streptothricins; D010130:p-Aminohippuric Acid