Responses of resistance and capacitance vessels in human nasal mucosa to beta-receptor agonists.
To investigate the responses of nasal vessels, divided into resistance and capacitance vessels, to a beta-receptor agonist in human, mucosal blood flow of the inferior turbinate and nasal airway resistance were measured when 1.5 mg terbutaline was applied topically. Mucosal blood flow was measured by the hydrogen clearance method just beneath the site where terbutaline in physiological saline (0.02 ml) was applied on an extremely localized area of the nasal mucosa. Nasal airway resistance of the ipsilateral and contralateral nasal cavities was measured separately by anterior rhinomanometry when terbutaline in normal saline (0.1 ml) was sprayed in the unilateral nasal cavity. Topical application of terbutaline elicited neither a significant increase of mucosal blood flow of the inferior turbinate nor an increase of nasal airway resistance. beta-Receptors seem not to be as densely distributed both in the resistance vessels and in the capacitance vessels as to cause vasodilatation by their activation in the nasal mucosa.
Konno
A
A
Terada
N
N
Okamoto
Y
Y
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D006801:Humans; D009297:Nasal Mucosa / Q000098:blood supply*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects; D013726:Terbutaline / Q000494:pharmacology*; D014420:Turbinates / Q000098:blood supply; D014655:Vascular Resistance / Q000187:drug effects*
D011943:Receptors, Adrenergic, beta; D013726:Terbutaline