[Effector modeling of the action of GABA-receptor complex ligands. Functional interactions of subunits of the complex].
The distribution of the minimum effective doses of bicuculline, corasole and picrotoxin was studied in intact mice and in mice administered different doses of 1.4-benzodiazepines (phenazepam and its 1,2,4,5-tetrahydroxy derivatives) and sodium barbital. The changes in the "dose-response" relationship for thiosemicarbazide have been observed with the administration of the increasing doses of phenazepam and sodium barbital. The effects registered correspond to the modifications of the GABA-receptor complex by exogenous ligands. The forms of the "dose-response" relationship observed, the types of the antagonism between pharmacological agents and the cooperation of their interaction correspond to the indices obtained from the "quartet" model of the receptor-channel complex.
Zhuk
O V
OV
Golovenko
N Ia
NIa
Zin'kovskiiĭ
V G
VG
D000818:Animals; D001462:Barbital / Q000008:administration & dosage; D001569:Benzodiazepines / Q000008:administration & dosage; D001640:Bicuculline / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008024:Ligands; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008954:Models, Biological; D010433:Pentylenetetrazole / Q000494:pharmacology*; D010852:Picrotoxin / Q000494:pharmacology*; D011963:Receptors, GABA-A / Q000032:analysis / Q000187:drug effects*
D001462:Barbital; D001569:Benzodiazepines; D001640:Bicuculline; D008024:Ligands; D010433:Pentylenetetrazole; D010852:Picrotoxin; D011963:Receptors, GABA-A
Effektornoe modelirovanie deĭstviia ligandov GAMK-retseptornogo kompleksa. Funktsional'noe vzaimodeĭstvie sub"edinits kompleksa.