[The monooxygenase system, lipid peroxidation in the liver and vitamin B12 metabolism in experimental poisoning of rabbits with phenylhydrazine].
It has been demonstrated that phenylhydrazine poisoning results in a significant activation of lipid peroxidation, reduction of dimethylaniline N-demethylation and NADPH-2.6-dichlorophenolindophenol and NADPH-cytochrome c-reductase activities as well as in the stimulation of the NADPH-nitrotetrazolium reductase activity in rabbit liver microsomes. In addition, phenylhydrazine administration causes disturbances in vitamin B12 metabolism which are manifested as changes in total cobalamin pool and in the spectrum of vitamin B12 individual physiologically active forms in the blood.
Poznanskaia
A A
AA
Korsova
T L
TL
Morozova
N A
NA
Tsukerman
E S
ES
Kurganov
B I
BI
D000818:Animals; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology* / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010659:Phenylhydrazines / Q000506:poisoning*; D011817:Rabbits; D014805:Vitamin B 12 / Q000378:metabolism*
D010659:Phenylhydrazines; C030299:phenylhydrazine; D006899:Mixed Function Oxygenases; D014805:Vitamin B 12
Monoksigenaznaia sistema, perekisnoe okislenie lipidov v pecheni i obmen vitamina B12 pri éksperimental'nom otravlenii krolikov fenilgidrazinom.