title: Early recognition of recurrent hepatocellular carcinoma utilizing gallium-67 citrate scintigraphy.
abstract: Gallium-67 scintigraphy is a valuable test together with other screening tests such as alpha feto-protein (AFP) and other imaging modalities in following up recurrent hepatocellular carcinoma (HCC). Three patients were followed in our institution for intervals varying from 2-24 mo after successful resection of uninodular localized hepatomas. In the first patient, gallium scan showed abnormal localized activity while the computed tomography (CT) scan and the magnetic resonance imaging were negative. Liver function tests and AFP were also normal and the patient was operated upon only on the basis of the gallium scan. The second patient had a follow-up gallium scan 2 mo after the first operation that showed an area of increased activity along the inferior aspect of the right lobe. A CT scan done after that showed no evidence of recurrence, but subsequently became positive when repeated 4 mo later. The third patient had abnormal simultaneous gallium scan and CT scan demonstrating a recurrence in the left adrenal gland while both AFP and carcinoembryonic antigen were normal. This has led us to consider every patient a candidate for a baseline and follow-up gallium scan for evaluation for recurrence following HCC.
authors.affiliation: Department of Radiology, University of Miami School of Medicine, Florida.
authors.forename: A N
authors.initials: AN
authors.lastname: Serafini
authors.forename: L J
authors.initials: LJ
authors.lastname: Jeffers
authors.forename: K R
authors.initials: KR
authors.lastname: Reddy
authors.forename: S
authors.initials: S
authors.lastname: Heiba
authors.forename: E R
authors.initials: ER
authors.lastname: Schiff
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000556:secondary; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging
chemical_list: D005710:Gallium Radioisotopes