title: Structure and mobilization of an ampicillin and gentamicin resistance determinant.
abstract: A DNA segment originally found in an epidemic plasmid of Escherichia coli encoding an aminoglycoside-(3)-N-acetyltransferase gene (aacC5) and a TEM-type beta-lactamase gene was characterized. The two genes were adjacent and constituted a single transcriptional unit. In addition, these genes were simultaneously mobilized through the action of an insertion sequence related to IS26, IS140, and IS15-delta. This DNA segment is a composite transposon which has been called Tn2922.
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.forename: R
authors.initials: R
authors.lastname: Gomez-Lus
authors.forename: J M
authors.initials: JM
authors.lastname: Ortiz
authors.forename: J M
authors.initials: JM
authors.lastname: Garcia-Lobo
mesh_terms: D000667:Ampicillin / Q000494:pharmacology*; D001483:Base Sequence; D003470:Culture Media; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000032:analysis* / Q000302:isolation & purification / Q000648:ultrastructure; D005798:Genes, Bacterial; D005839:Gentamicins / Q000494:pharmacology*; D008854:Microscopy, Electron; D009154:Mutation; D010403:Penicillin Resistance / Q000235:genetics; D010957:Plasmids; D014158:Transcription, Genetic
chemical_list: D003470:Culture Media; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D005839:Gentamicins; D000667:Ampicillin