[Neurologic effects of acyclovir after an allogenic marrow graft].
On the 4th day of acyclovir treatment for Herpes simplex pneumonia, a 28 month-old girl who had received allogenic marrow transplant for stage IV neuroblastoma presented with severe neurologic disorders including coma and choreic movements. These symptoms disappeared 9 days after acyclovir was stopped. The disturbance in acyclovir kinetics because of acute renal failure and/or a cerebral cortex atrophy might explain the poor neurologic tolerance of acyclovir. This reversible neurologic involvement on a prone patient should be known as a differential diagnosis of Herpes simplex encephalitis.
Burguet
A
A
Service de Réanimation Infantile Polyvalente et Prématurés, CHU, Besançon.
Menget
A
A
Fromentin
C
C
Plouvier
E
E
Amsallem
D
D
Noir
A
A
Lokiec
F
F
D000212:Acyclovir / Q000009:adverse effects*; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D002819:Chorea / Q000139:chemically induced*; D003128:Coma / Q000139:chemically induced*; D006566:Herpesviridae Infections / Q000188:drug therapy; D006801:Humans; D011183:Postoperative Complications; D014184:Transplantation, Homologous
D000212:Acyclovir
Effets neurologiques de l'aciclovir après greffe de moelle allogénique.