title: The leukaemic hairy cell in culture lacks the monocyte marker, angiotensin converting enzyme induction.
abstract: Hairy cells of hairy cell leukaemia are unique circulating mononuclear cells of questionable origin which possess features of both B-lymphocytes and monocytes. Angiotensin converting enzyme, which is consistently induced in monocytes in culture, was not induced in hairy cells in culture. This result is consistent with a lymphocytic rather than a normal monocytic cell lineage for the hairy cell. The origin of other monocytic phenotypic characteristics remains to be explained.
authors.affiliation: Department of Medicine, State University of New York, Brooklyn, New York 11203.
authors.forename: E
authors.initials: E
authors.lastname: Silverstein
authors.forename: J
authors.initials: J
authors.lastname: Friedland
authors.forename: R
authors.initials: R
authors.lastname: Silber
mesh_terms: D004790:Enzyme Induction; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000201:enzymology*; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis*; D014407:Tumor Cells, Cultured
chemical_list: D007703:Peptidyl-Dipeptidase A