Do human T-lymphotrophic viruses (HTLVs) and other enveloped viruses induce autoimmunity in multiple sclerosis?
A virally induced autoimmune reaction may be important in the pathogenesis of multiple sclerosis. The role that glycolipids and myelin basic protein presented to the virus may play in this process is considered. The most likely cells to be the source of autoantigens are neurons, myelin and oligodendrocytes. Viral infection of class II-expressing cells and association of the viral envelope autoantigens and the class II molecules could trigger an autoimmune reaction. It is suggested that for MS to develop following a virus infection the virus will need to cause expression of class II antigens on brain cells as well as fulfill the same role as an antigen presenting cell. The part which T-lymphotrophic viruses (HTLVs) and other enveloped viruses may play in this phenomenon is discussed.
Dalgleish
A G
AG
CRC, Northwick Park Hospital, Harrow, UK.
Fazakerley
J K
JK
Webb
H E
HE
D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology*; D017977:Deltaretrovirus / Q000276:immunology*; D003711:Demyelinating Diseases / Q000276:immunology; D004660:Encephalitis / Q000276:immunology; D006017:Glycolipids / Q000276:immunology; D006801:Humans; D009103:Multiple Sclerosis / Q000209:etiology / Q000276:immunology*; D009185:Myelin Proteins / Q000276:immunology; D014780:Viruses / Q000276:immunology
D001324:Autoantigens; D006017:Glycolipids; D009185:Myelin Proteins