ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo.
Treatment of rats in vivo with ACTH provoked increases in whole adrenal contents of phosphatidylinositol and diacylglycerol. Concomitantly, C-kinase activity decreased in cytosol and increased stoichiometrically in the membrane fraction. It appears that the de novo phospholipid synthesis effect of ACTH is accompanied by increases in diacylglycerol and translocative activation of the C-kinase system.
Farese
R V
RV
Veterans Administration Hospital, Tampa, Florida.
Fanjul
L F
LF
de Ruiz Galarreta
C M
CM
Davis
J S
JS
Cooper
D R
DR
D000311:Adrenal Glands / Q000201:enzymology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003600:Cytosol / Q000201:enzymology; D004075:Diglycerides / Q000096:biosynthesis*; D005989:Glycerides / Q000096:biosynthesis*; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D013347:Subcellular Fractions / Q000201:enzymology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D004075:Diglycerides; D005989:Glycerides; D000324:Adrenocorticotropic Hormone; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate