title: Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioral findings.
abstract: Six of eight patients with obsessive-compulsive disorder had an exacerbation of symptoms when given m-chlorophenylpiperazine. Fenfluramine and placebo produced mild improvement. Six patients given intravenous clonidine experienced marked reduction in obsessions. Implications for serotonergic and noradrenergic hypotheses of obsessive-compulsive disorder are discussed.
authors.affiliation: Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032.
authors.forename: E
authors.initials: E
authors.lastname: Hollander
authors.forename: M
authors.initials: M
authors.lastname: Fay
authors.forename: B
authors.initials: B
authors.lastname: Cohen
authors.forename: R
authors.initials: R
authors.lastname: Campeas
authors.forename: J M
authors.initials: JM
authors.lastname: Gorman
authors.forename: M R
authors.initials: MR
authors.lastname: Liebowitz
mesh_terms: D000328:Adult; D003000:Clonidine / Q000494:pharmacology; D005277:Fenfluramine / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D010879:Piperazines / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology*
chemical_list: D010879:Piperazines; D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin; D005277:Fenfluramine; D003000:Clonidine; C015068:1-(3-chlorophenyl)piperazine