Specific amino acid substitutions are not required for transformation by v-myb of avian myeloblastosis virus.
The protein product of the v-myb oncogene of avian myeloblastosis virus, p48v-myb, differs structurally in several ways from its normal cellular homolog, p75c-myb. We demonstrated that the 11 specific amino acid substitutions found in two independent molecular clones of this virus were not required for the transformation of myeloblasts by v-myb.
Stober-Grässer
U
U
Department of Pathology, University of California, San Diego, La Jolla 92093.
Lipsick
J S
JS
D000595:Amino Acid Sequence; D000818:Animals; D001354:Avian Leukosis Virus / Q000502:physiology*; D009189:Avian Myeloblastosis Virus / Q000235:genetics / Q000502:physiology*; D002472:Cell Transformation, Viral; D002642:Chick Embryo; D006412:Hematopoietic Stem Cells; D020626:Oncogene Proteins v-myb; D012191:Retroviridae Proteins / Q000235:genetics / Q000502:physiology*
D020626:Oncogene Proteins v-myb; D012191:Retroviridae Proteins