Absence of effect of estrogen on dopamine, norepinephrine and beta-endorphin-like immunoreactivity in human plasma.
The plasma concentrations of immunoreactive norepinephrine (NE), dopamine (DA), beta-endorphin (beta-E), luteinizing hormone (LH) and follicle stimulating hormone (FSH) were determined by RIA and HPLC every 6 h until 72 h after iv administration of conjugated estrogens during the midfollicular phase. The LH level showed a biphasic pattern after the injection of conjugated estrogens, i.e. significant suppression (-50%) for 6-42 h after the injection, followed by a rebound increase with a peak (+85%) at 72 h. The plasma levels of immunoreactive beta-E, NE and DA did not change significantly for 72 h after the injection.
Miyake
A
A
Department of Obstetrics and Gynecology, Osaka School of Medicine, Japan.
Nishizaki
T
T
Ohtsuka
S
S
Yoshimoto
Y
Y
Aono
T
T
Tanizawa
O
O
D000328:Adult; D004298:Dopamine / Q000097:blood*; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D009638:Norepinephrine / Q000097:blood*; D001615:beta-Endorphin / Q000097:blood*
D004966:Estrogens, Conjugated (USP); D001615:beta-Endorphin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D004298:Dopamine; D009638:Norepinephrine