Radical trapping and lipid peroxidation during myocardial reperfusion injury--radical scavenging by troxerutin in comparison to mannitol.
During ischemic perfusion and reperfusion of isolated rat hearts, OH and carbon-centered radicals were trapped in the perfusate. Both radicals were found to occur during LPO which was enhanced in the myocardium. The increase of LPO as well as of enzyme leakage were reduced by mannitol and the flavonoid troxerutin showing antioxidative action of greater than 500 and greater than 5 microM, respectively. The assumption is supported that radical-induced LPO is of pathogenetic relevance during myocardial reperfusion injury for which antioxidants could be of therapeutic advantage.
Blasig
I E
IE
Acad. Sci. GDR, Inst. Drug. Res., Berlin.
Löwe
H
H
Ebert
B
B
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D003327:Coronary Disease / Q000188:drug therapy / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives / Q000494:pharmacology; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000975:Antioxidants; D005609:Free Radicals; D006896:Hydroxyethylrutoside; D008054:Lipid Peroxides; D008353:Mannitol; C005865:troxerutin; D007770:L-Lactate Dehydrogenase