No-carrier-added radiobromination via cuprous chloride-assisted nucleophilic aromatic bromodeiodination.
Cuprous chloride-assisted aromatic bromodeiodination was investigated as a regioselective no-carrier-added labelling technique. Using 77Br-, CuCl and simple iodinated aromatic substrates in DMSO, radiochemical yields ranged from 60 to 90% after 30 min at 135 degrees C. The methodology described here holds potential for the convenient labelling of radiopharmaceuticals with 75Br, 76Br or 77Br.
Moerlein
S M
SM
Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
Hwang
D R
DR
Welch
M J
MJ
D001967:Bromine Radioisotopes; D003300:Copper; D007553:Isotope Labeling / Q000379:methods*
D001967:Bromine Radioisotopes; D003300:Copper; C028419:cuprous chloride