Parvoviruses: infections and arthropathies.
Parvoviruses (PVs) are unique in that they are the only single-stranded DNA viruses of vertebrates. Two human PVs have now been described and characterized, and genomes sequenced: B19 and RA-1. The B19 PV is known to be associated with arthritis in humans, and RA-1 was recovered from the synovial cells of a patient with rheumatoid arthritis. This article will discuss the nature of these two viruses, their possible relationships to chronic joint disease of humans, and the clinical illnesses of B19 infection.
Smith
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CA
Montefiore Medical Center, Bronx, New York.
Woolf
A D
AD
Lenci
M
M
D000367:Age Factors; D001170:Arthritis, Infectious / Q000209:etiology*; D002648:Child; D004890:Erythema / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D010322:Parvoviridae Infections / Q000473:pathology*; D012737:Sex Factors