Renal tubular function in patients treated with high-dose cisplatin.
The effect of three cycles of high-dose cisplatin (40 mg/m2 day for 5 days) on renal tubular function was evaluated in 30 patients. A significant impairment of proximal tubular salt and water reabsorption rates was observed, but also distal tubular function seemed to be affected. These changes were also present 6 months after termination of treatment. Sodium and magnesium clearance increased significantly during treatment. Magnesium clearance normalized shortly after treatment but sodium clearance was significantly elevated 6 months after treatment. Proteinuria, albuminuria, and amino aciduria, together with an increase of beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) excretion rates, were observed during each treatment cycle. A good correlation was registered between the increase in urinary excretion rates of protein, NAG, and magnesium and the decrease in proximal tubular salt and water reabsorption during cisplatin administration.
Daugaard
G
G
Department of Oncology ONB and Clinical Physiology, Finsen Institute, Copenhagen, Denmark.
Abildgaard
U
U
Holstein-Rathlou
N H
NH
Bruunshuus
I
I
Bucher
D
D
Leyssac
P P
PP
D000118:Acetylglucosaminidase / Q000652:urine; D000293:Adolescent; D000328:Adult; D000419:Albuminuria / Q000139:chemically induced; D000596:Amino Acids / Q000652:urine; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D007686:Kidney Tubules, Distal / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D008274:Magnesium / Q000378:metabolism / Q000652:urine; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy; D011507:Proteinuria / Q000139:chemically induced; D012964:Sodium / Q000378:metabolism; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000652:urine
D000596:Amino Acids; D001613:beta 2-Microglobulin; D012964:Sodium; D000118:Acetylglucosaminidase; D008274:Magnesium; D002945:Cisplatin