Changes in the expression of superoxide dismutase and catalase as a function of age and dietary restriction.
The activities of superoxide dismutase (Cu/Zn) and catalase were observed to decrease significantly between 6 and 29 months of age in rat liver. The decrease in superoxide dismutase and catalase activity was paralleled by a decrease in the levels of the mRNA species coding for these enzymes and the nuclear transcription of the superoxide dismutase and catalase genes. Life-long dietary restriction was shown to increase the expression (i.e. activities, mRNA levels, and nuclear transcription) of superoxide dismutase and catalase in liver tissue from 18-month-old rats.
Semsei
I
I
Department of Chemistry, Illinois State University, Normal 61761.
Rao
G
G
Richardson
A
A
D000375:Aging; D000818:Animals; D002374:Catalase / Q000235:genetics* / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D004038:Diet, Reducing; D015971:Gene Expression Regulation, Enzymologic; D008099:Liver / Q000201:enzymology / Q000254:growth & development*; D008297:Male; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics*; D051381:Rats; D011916:Rats, Inbred F344; D012016:Reference Values; D013482:Superoxide Dismutase / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
D012333:RNA, Messenger; D002374:Catalase; D013482:Superoxide Dismutase