[Arterial administration of oily anticancer agents dissolved in lipiodol fluid in recurrence of hepatoma after hepatic resection and in metastatic liver cancer].
Oily anticancer agents such as SMANCS dissolved in Lipiodol fluid (Lipiodol) were administered to 18 patients with recurrence of hepatocellular carcinoma after hepatic resection and to 87 patients with metastatic liver cancer. The following results were obtained. i) It was proved and to that Lipiodol worked as a carrier of anticancer drugs and that targeting chemotherapy could be achieved. ii) The serum AFP level and tumor size showed a decrease in 91% and 87% of patients with recurrence of hepatoma, respectively. iii) This method could be applied to extrahepatic metastasis of hepatoma, and anticancer activity was also observed in these lesions. iv) The serum CEA level was decreased in 53 patients (83%) and reduction of tumor size was observed in 32 patients (46%) with metastatic liver cancer. v) In 5 out of 7 tumors resected after arterial injection of oily anticancer agents, necrosis was found histologically in over 95% of the tumor.
Ohtsuka
N
N
1st Dept. of Surgery, Kumamoto University Medical School.
Konno
T
T
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D003131:Combined Modality Therapy; D005663:Furans / Q000008:administration & dosage*; D006498:Hepatectomy; D006801:Humans; D007261:Infusions, Intra-Arterial; D007459:Iodized Oil / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008299:Maleic Anhydrides / Q000008:administration & dosage*; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage*; D011137:Polystyrenes / Q000008:administration & dosage*; D011184:Postoperative Period; D009353:Zinostatin / Q000008:administration & dosage* / Q000031:analogs & derivatives
D000903:Antibiotics, Antineoplastic; D005663:Furans; D008299:Maleic Anhydrides; D008937:Mitomycins; D011137:Polystyrenes; C035755:poly(maleic acid-styrene)neocarzinostatin; D016685:Mitomycin; D007459:Iodized Oil; D009353:Zinostatin