Limited stimulus generalization between delta 9-THC and diazepam in pigeons and gerbils.
Pigeons trained to discriminate between the presence and absence of delta 9-THC (0.56 mg/kg, IM, intramuscularly) were tested with diazepam (5.6-30 mg/kg), administered IG (intragastrically), and were found to generalize the response associated with the THC training to the diazepam treatment only to a limited extent. Two groups of gerbils trained to discriminate between the presence and absence of IP (intraperitoneally) injected benzodiazepine agonists (5.6 mg/kg of diazepam and Ro 11-3128, respectively) generally did not generalize the drug response to IP administered THC (5.6 and 17.5 mg/kg). In addition, substitution testing with the dopamine autoreceptor blocker (+)-3PPP yielded non-drug responding in the pigeons. Hence neither proposed structural similarity between 3-PPP and THC, nor purported anxiolytic activity by 3-PPP (see Introduction) matched the THC-induced stimulus effects. The data are discussed with reference to the specificity of the THC cue or stimulus.
Järbe
T U
TU
University of Uppsala, Department of Psychology, Sweden.
Hiltunen
A J
AJ
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D010856:Columbidae; D003975:Diazepam / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects; D013759:Dronabinol / Q000494:pharmacology*; D005795:Generalization, Stimulus / Q000187:drug effects*; D005849:Gerbillinae; D008297:Male; D010880:Piperidines / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects; D002998:Clonazepam / Q000031:analogs & derivatives
D001570:Benzodiazepinones; D003975:Diazepam; D013759:Dronabinol; D010880:Piperidines; D011963:Receptors, GABA-A; C026539:preclamol; C020602:meclonazepam; D002998:Clonazepam