title: Dexamethasone-induced reduction of phospholipase D activity in the rat. Possible role of lipocortin.
abstract: Subcutaneous injection of dexamethasone resulted in a reduction of demonstrable phospholipase D activity of rat brain and liver microsomes. Partially purified rat lung lipocortin inhibited the activity of both microsomal and partially purified rat brain phospholipase D. These results show that phospholipase D activity is suppressed by dexamethasone and one of the possible mechanisms of inhibition may be a phospholipase inhibitory protein, lipocortin.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: V S
authors.initials: VS
authors.lastname: Bansal
authors.forename: I
authors.initials: I
authors.lastname: Singh
authors.forename: J N
authors.initials: JN
authors.lastname: Kanfer
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D017302:Annexins; D001921:Brain / Q000201:enzymology; D003907:Dexamethasone / Q000494:pharmacology*; D002798:Diacylglycerol Cholinephosphotransferase / Q000378:metabolism; D006023:Glycoproteins / Q000502:physiology*; D008099:Liver / Q000201:enzymology; D008297:Male; D008780:Methyltransferases / Q000378:metabolism; D008861:Microsomes / Q000201:enzymology; D050918:Phosphatidylethanolamine N-Methyltransferase; D010739:Phospholipase D / Q000378:metabolism*; D010740:Phospholipases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D017302:Annexins; D006023:Glycoproteins; D003907:Dexamethasone; D008780:Methyltransferases; D050918:Phosphatidylethanolamine N-Methyltransferase; D002798:Diacylglycerol Cholinephosphotransferase; D010740:Phospholipases; D010739:Phospholipase D