[The effect of nizoral on hypophyseal gonadotropic function and the production of sex steroid hormones by the testes and ovaries in human subjects and experimental animals].
Experiments with mature male and female rats and female mice have shown that nizoral, a nonsteroid estrogenic drug, in a dose of 10 mg/kg stimulates estradiol production in male and female rats, suppresses basal and stimulates LH production, promotes a relative predominance of FSH in female animals, and suppresses FSH in male rats. In humans of a reproductive age, orally taking 200 mg of nizoral during 1-26 weeks, the drug stimulates FSH and LH production, suppressing estradiol production in men. The blood levels of prolactin, testosterone and progesterone are unchanged (the hypophyseal gonadotropic and the peripheral steroid hormones have been radioimmunoassayed). The detected shifts in the hormonal regulation of the reproductive system during nizoral therapy is evidence that nizoral should be very cautiously administered to patients with dyshormonal diseases, with the hormonal profile monitored over the course of treatment.
Shuginina
E A
EA
Krivosheev
O G
OG
Potekaev
N S
NS
Nabatchikova
N A
NA
D000328:Adult; D000368:Aged; D000818:Animals; D004971:Estrus / Q000187:drug effects; D005260:Female; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis* / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D007654:Ketoconazole / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D010053:Ovary / Q000187:drug effects*; D010902:Pituitary Gland / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000187:drug effects*; D013997:Time Factors
D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D007654:Ketoconazole
Vliianie nizorala na gonadotropnuiu funktsiiu gipofiza i produktsiiu polovykh steroidnykh gormonov semennikami i iachnikami u cheloveka i éksperimental'nykh zhivotnykh.