Inhibition of growth and development of the transplantable C-6 glioma cells inoculated in rats by retinoids and carotenoids.
Experimental data were provided to demonstrate the inhibitory effects of retinoids (retinal, retinoic acid, retinyl acetate and retinyl palmitate) and carotenoids (beta-carotene, lycopene and crocetin) on the growth and development of the C-6 glioma cells inoculated in rats. In the pretreatment experiments, most of these compounds could prolong the latency period of T50 (time for 50% tumor incidence). At week 7, the growth inhibition was 57-67% (P less than 0.02) with carotenoids and 40-55% (P less than 0.05) with retinoids. In the post-treatment experiments, the growth inhibition was 30-55% (P less than 0.05) with carotenoids and 21-42% (P less than 0.05) with retinoids. No significant hepatotoxic effect was observed in all treated groups as indicated by the constant levels of serum enzymes (e.g. aspartate amino-transferase, alanine amino-transferase and alkaline phosphatase) and bilirubin. The mechanisms of tumor inhibition through the enhancement of anti-tumor immunity by both carotenoids and retinoids were discussed.
Wang
C J
CJ
Institute of Biochemistry, National Taiwan University, College of Medicine, ROC.
Chou
M Y
MY
Lin
J K
JK
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002338:Carotenoids / Q000627:therapeutic use*; D005910:Glioma / Q000188:drug therapy* / Q000473:pathology; D008099:Liver / Q000201:enzymology; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D012176:Retinoids / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
D012176:Retinoids; D002338:Carotenoids