title: New delta-receptor antagonists.
abstract: A new delta-selective opiate antagonist has been synthesised in which the two glycine residues of diallyl leucine enkephalin have been replaced by 4-aminobenzoic acid. The compound has a different conformation to that of ICI 174,864 (N,N-diallyl-Tyr-Aib-Aib-Phe-Leu).
authors.affiliation: Department of Chemistry, ICI Pharmaceuticals Division, Alderley Park, Cheshire, UK.
authors.forename: C W
authors.initials: CW
authors.lastname: Thornber
authors.forename: J S
authors.initials: JS
authors.lastname: Shaw
authors.forename: L
authors.initials: L
authors.lastname: Miller
authors.forename: C F
authors.initials: CF
authors.lastname: Hayward
authors.forename: J S
authors.initials: JS
authors.lastname: Morley
authors.forename: D
authors.initials: D
authors.lastname: Timms
authors.forename: A
authors.initials: A
authors.lastname: Wilkinson
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009292:Narcotic Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects* / Q000378:metabolism; D017465:Receptors, Opioid, delta; D014649:Vas Deferens / Q000187:drug effects / Q000502:physiology
chemical_list: D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta