An animal model for tinnitus.
Subjective tinnitus remains obscure, widespread, and without apparent cure. In the absence of a suitable animal model, past investigations took place in humans, resulting in studies that were understandably restricted by the nature of human investigation. Within this context, the development of a valid animal model would be considered a major breakthrough in this field of investigation. Our results showed changes in the spontaneous activity of single neurons in the inferior colliculus, consistent with abnormally increased neuronal activity within the auditory pathways after manipulations known to produce tinnitus in man. A procedure based on a Pavlovian conditioned suppression paradigm was recently developed that allows us to measure tinnitus behaviorally in conscious animals. Accordingly, an animal model of tinnitus is proposed that permits tests of hypotheses relating to tinnitus generation, allowing the accommodation of interventional strategies for the treatment of this widespread auditory disorder.
Jastreboff
P J
PJ
Section of Otolaryngology, Yale University School of Medicine, New Haven, CT 06510.
Brennan
J F
JF
Sasaki
C T
CT
D000818:Animals; D001306:Auditory Pathways / Q000503:physiopathology; D001307:Auditory Perception / Q000187:drug effects; D001522:Behavior, Animal; D003214:Conditioning, Classical / Q000502:physiology; D004195:Disease Models, Animal; D004594:Electrophysiology; D006168:Guinea Pigs; D007245:Inferior Colliculi / Q000503:physiopathology; D008297:Male; D051381:Rats; D012980:Sodium Salicylate / Q000633:toxicity; D009435:Synaptic Transmission; D014012:Tinnitus / Q000209:etiology
D012980:Sodium Salicylate