title: Oxygenation mechanism in the oxidation of xenobiotic aldehyde to carboxylic acid by mouse hepatic microsomes.
abstract: 11-Oxo-delta 8-tetrahydrocannabinol was oxidized to delta 8-tetrahydrocannabinol-11-oic acid by mouse hepatic microsomes. The oxygenation mechanism in the reaction was confirmed by the incorporation of oxygen-18 from molecular oxygen into delta 8-tetrahydrocannabinol-11-oic acid. The oxygenation of aldehyde to carboxylic acid represents a novel mechanism in biological oxidation of aldehyde to carboxylic acid.
authors.affiliation: Department of Hygienic Chemistry, School of Pharmacy, Hokuriku University, Kanazawa, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Narimatsu
authors.forename: H
authors.initials: H
authors.lastname: Yoshimura
mesh_terms: D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D002264:Carboxylic Acids / Q000096:biosynthesis*; D013759:Dronabinol / Q000031:analogs & derivatives / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism*
chemical_list: D000447:Aldehydes; D002264:Carboxylic Acids; D013759:Dronabinol; D006899:Mixed Function Oxygenases