Suppression of RNA synthesis by a specific antiviral activity in Sindbis virus-infected Aedes albopictus cells.
An antiviral protein is released by mosquito cells persistently infected with Sindbis virus. Differences in both sensitivity to and production of this virus-specific activity were apparent in three independently produced Aedes albopictus cell lines. This activity inhibits total viral RNA synthesis in a time-dependent manner. The antiviral effect is maximally realized when cells are treated with the activity 48 h before infections. These data suggest that the antiviral activity induces an antiviral state in treated cells which prevents the formation or efficient function of viral RNA-synthesizing complexes.
Condreay
L D
LD
Cell Research Institute, University of Texas at Austin 78712.
Brown
D T
DT
D000330:Aedes / Q000382:microbiology*; D000818:Animals; D000998:Antiviral Agents; D002460:Cell Line; D012367:RNA, Viral / Q000096:biosynthesis*; D012845:Sindbis Virus / Q000502:physiology*; D013045:Species Specificity; D014036:Togaviridae Infections / Q000382:microbiology*
D000998:Antiviral Agents; D012367:RNA, Viral