Modulation of mild bleeding disorder during remissions and exacerbations of Graves' disease.
A patient with Graves' disease had a symptomatic thrombocytopathy during periods of remission. When euthyroid, she noticed bruising, petechiae, and epistaxis. Hemostatic abnormalities included prolongation of the bleeding time by aspirin, reduced platelet retention (a second-phase defect), and abnormal thrombin-induced aggregation and serotonin release. When hyperthyroid, bleeding symptoms resolved, and platelet function returned to normal. These observations suggest that mild bleeding disorders may be influenced either directly or indirectly by thyroid hormone levels.
Zeigler
Z R
ZR
Department of Medicine, Montefiore Hospital, University of Pittsburgh School of Medicine, PA 15213.
Iannuzzi
D
D
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D004844:Epistaxis / Q000097:blood / Q000209:etiology*; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D011693:Purpura / Q000097:blood / Q000209:etiology*; D012074:Remission Induction; D012701:Serotonin / Q000378:metabolism; D013917:Thrombin / Q000494:pharmacology; D013974:Thyroxine / Q000009:adverse effects / Q000627:therapeutic use
D012701:Serotonin; D013917:Thrombin; D013974:Thyroxine