title: Ageing and alpha 1 adrenoceptors in the iris.
abstract: This study was undertaken to determine if the age related decrease in pupil size is attributable to altered sympathetic adrenoceptor responsiveness. Log dose response curves using the selective alpha 1 agonist phenylephrine and antagonist thymoxamine showed that there is no difference in alpha 1 adrenoceptor sensitivity in the elderly and the young. Therefore age related miosis is not caused by an alteration in alpha 1 receptors with age.
authors.affiliation: Research Department, Royal Victoria Eye and Ear Hospital, Dublin.
authors.forename: C
authors.initials: C
authors.lastname: Buckley
authors.forename: D M
authors.initials: DM
authors.lastname: Curtin
authors.forename: J
authors.initials: J
authors.lastname: Docherty
authors.forename: P
authors.initials: P
authors.lastname: Eustace
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007498:Iris / Q000502:physiology*; D013948:Moxisylyte / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*
chemical_list: D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine; D013948:Moxisylyte