title: Myocardial uptake of thallium-201 diethyldithiocarbamate (201T1-DDC) in cultured heart cells and in humans.
abstract: We assessed the feasibility of SPECT imaging with 201T1-diethyldithiocarbamate (201T1-DDC), a new cerebral blood flow tracer with little distribution, expecting to observe less extensive redistribution than with 201T1-chloride. Myocardial sections were obtained in three patients presenting with documented coronary artery disease and injected at peak exercise with 100 MBq 201T1-DDC. In two patients there was a clear redistribution phenomenon at four h after injection. In cultured myocardial cells of newborn rats, the uptake and washout of 201T1-chloride and 201T1-DDC were compared. The 201T1-DDC uptake was lower than 201T1-chloride (transmembrane gradients were respectively 89 +/- 10 and 4.1 +/- 0.2, mean +/- sem, n = 14, P less than 0.001). After 2 h washout in a T1 free medium, the retention of 201T1-chloride in the cells was 4% vs 19% for 201T1-DDC. It is concluded that although myocardial imaging is feasible with 201T1-DDC, this agent redistributes significantly with time.
authors.affiliation: Centre Jean Perrin B.P. 63011, University of Clermont-Ferrand, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Maublant
authors.forename: N
authors.initials: N
authors.lastname: Moins
authors.forename: E A
authors.initials: EA
authors.lastname: Van Royen
authors.forename: J R
authors.initials: JR
authors.lastname: Lusson
authors.forename: J
authors.initials: J
authors.lastname: Cassagnes
authors.forename: A
authors.initials: A
authors.lastname: Veyre
authors.forename: P
authors.initials: P
authors.lastname: Gachon
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003327:Coronary Disease / Q000000981:diagnostic imaging; D004050:Ditiocarb; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D051381:Rats; D013794:Thallium Radioisotopes; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
chemical_list: D013794:Thallium Radioisotopes; D004050:Ditiocarb