Necrotizing myopathy with paracrystalline inclusion bodies in hypervitaminosis E.
A necrotizing, nonprogressive myopathy with unusual paracrystalline inclusion bodies is described in a patient who underwent long-term treatment with megadoses of vitamin E. The clinical course and morphological findings suggest a close relationship to the administration of the vitamin. The theoretical pathogenesis of muscle damage and the possible origin of paracrystalline inclusion bodies are discussed.
Bardosi
A
A
Department of Neuropathology, University of Göttingen, Federal Republic of Germany.
Dickmann
U
U
D001706:Biopsy; D003460:Crystallization; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008875:Middle Aged; D009132:Muscles / Q000473:pathology / Q000648:ultrastructure; D009135:Muscular Diseases / Q000473:pathology*; D009336:Necrosis; D012651:Self Medication / Q000009:adverse effects; D014810:Vitamin E / Q000009:adverse effects / Q000378:metabolism*
D014810:Vitamin E