cis- and trans-acting regulation of gene expression of equine infectious anemia virus.
Deletion analysis of the equine infectious anemia virus long terminal repeat revealed that sequences responsive to virus-specific transactivation are located within the region spanning the transcriptional start site (-31 to +22). In addition, an active exon of a trans-acting factor (tat) was identified downstream of pol and overlapping env (nucleotides 5264 to 5461). Activation by tat is accompanied by an increase in the steady-state levels of mRNA directed by the equine infectious anemia virus long terminal repeat.
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Biological Carcinogenesis Development Program, National Cancer Institute Frederick Cancer Research Facility, Maryland 21701-1013.
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D000818:Animals; D002460:Cell Line; D005091:Exons; D005786:Gene Expression Regulation; D015696:Gene Products, tat; D004860:Infectious Anemia Virus, Equine / Q000235:genetics*; D010957:Plasmids; D012367:RNA, Viral / Q000096:biosynthesis; D012091:Repetitive Sequences, Nucleic Acid; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic; D014162:Transfection
D015696:Gene Products, tat; D012367:RNA, Viral; D014157:Transcription Factors