Reversal of the intrinsic effects of Ro 15-4513 on exploratory behavior by two benzodiazepine receptor antagonists.
In a holeboard test the imidazodiazepine Ro 15-4513 (1.5 and 3.0 mg/kg) reduced exploratory head-dipping. This effect was reversed both by the imidazodiazepine Ro 15-1788 (5 mg/kg) and by the beta-carboline ZK 93426 (2.5 mg/kg). These results indicate that the reduction in exploration caused by Ro 15-4513 is mediated by central benzodiazepine receptors.
Lister
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Laboratory of Clinical Studies, DICBR, NIAAA, Bethesda, MD 20892.
D000818:Animals; D001386:Azides / Q000494:pharmacology*; D001569:Benzodiazepines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects*; D005442:Flumazenil / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects*
D001386:Azides; D002243:Carbolines; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D005442:Flumazenil; C042568:ZK 93426; C042957:Ro 15-4513