Impaired mobility of human T lymphocyte surface molecules during inactive systemic lupus erythematosus. Relationship to a defective cAMP pathway.
The T lymphocytes of patients with active systemic lupus erythematosus (SLE) exhibit impaired capping of the surface molecules CD3, CD4, and CD8 and a defective cAMP-dependent pathway. Since the mobility of these molecules is regulated in part by cAMP, we sought to determine whether there is a specific defect(s) along the T cell cAMP pathway that contributes to the persistent capping disorder observed during inactive SLE. The data suggest that a defect may exist at the level of cAMP-dependent protein kinase activation or at a point distally. We propose that a disorder of cAMP-dependent protein kinase activity might account for the defect of capping observed in both the CD3, CD4 (helper/inducer) and CD3, CD8 (suppressor) subsets observed in SLE.
Kammer
G M
GM
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Mitchell
E
E
D012368:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone / Q000494:pharmacology; D000241:Adenosine / Q000494:pharmacology; D000328:Adult; D000954:Antigens, Surface / Q000276:immunology; D001386:Azides / Q000494:pharmacology; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007152:Immunologic Capping / Q000187:drug effects; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D011953:Receptors, Cyclic AMP / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D000954:Antigens, Surface; D001386:Azides; D011953:Receptors, Cyclic AMP; D005576:Colforsin; D012368:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; C017042:8-azidoadenosine-3',5'-monophosphate; D000242:Cyclic AMP; D000241:Adenosine