title: Double-blind crossover trial to compare the activity of nedocromil sodium and placebo in antigen challenge.
abstract: In a double-blind crossover placebo controlled study, the inhibitory effects of three different doses of nedocromil sodium on the immediate bronchoconstrictor response to antigen challenge were compared with a placebo. All the test treatments were inhaled three hours before challenge. Four asthmatic patients took part in the study and the test treatments were taken in a randomized order. All three doses of nedocromil sodium significantly reduced the bronchoconstrictor response and protected the patients against antigen challenge, compared with placebo. The highest dose of 2 mg was the most effective dose. All test doses of nedocromil sodium were safe and well tolerated by the patients.
authors.affiliation: Allergy Respiratory Unit, Regional General Hospital, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bonifazi
authors.forename: L
authors.initials: L
authors.lastname: Antonicelli
authors.forename: C
authors.initials: C
authors.lastname: Pieretti
authors.forename: E
authors.initials: E
authors.lastname: Piunti
authors.forename: R
authors.initials: R
authors.lastname: Rossini
authors.forename: F
authors.initials: F
authors.lastname: Patalano
authors.forename: F
authors.initials: F
authors.lastname: Ruggieri
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D001985:Bronchial Provocation Tests; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D017835:Nedocromil; D011804:Quinolines / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation
chemical_list: D011804:Quinolines; D017835:Nedocromil