title: Penetration of ciprofloxacin into saliva and nasal secretions and effect of the drug on the oropharyngeal flora of ill subjects.
abstract: The pharmacokinetics of ciprofloxacin and its effect on the oropharyngeal bacterial flora were examined in 21 ill patients being treated for methicillin-resistant Staphylococcus aureus infections or colonization or both. Oral ciprofloxacin (750 mg twice a day) produced peak and trough concentrations in serum of 2.56 +/- 1.80 and 0.97 +/- 0.81 micrograms/ml and steady-state salivary and nasal secretory concentrations of 1.29 +/- 1.0 and 1.84 +/- 0.91 micrograms/ml, respectively. Because of technical problems, nasal secretory concentrations were felt to represent rough approximations of true values. Oral ciprofloxacin therapy did not promote colonization of the oropharynx by gram-negative bacilli.
authors.affiliation: Medical Service, Veterans Administration Medical Center, Dallas, Texas.
authors.forename: E A
authors.initials: EA
authors.lastname: Piercy
authors.forename: R E
authors.initials: RE
authors.lastname: Bawdon
authors.forename: P A
authors.initials: PA
authors.lastname: Mackowiak
mesh_terms: D002939:Ciprofloxacin / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D008712:Methicillin / Q000494:pharmacology; D009297:Nasal Mucosa / Q000378:metabolism*; D009960:Oropharynx / Q000187:drug effects / Q000382:microbiology*; D010403:Penicillin Resistance; D012463:Saliva / Q000378:metabolism*; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology
chemical_list: D002939:Ciprofloxacin; D008712:Methicillin