title: HLA-DR Schwann cell reactivity in peripheral neuropathies of different origins.
abstract: HLA-DR antigens have been found on Schwann cells in peripheral neuropathies of different origins but not in normal control cases. Class II antigen reactivity was more intense in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and hereditary motor and sensory neuropathy type 1 (HMSN), but was also observed in toxic or metabolic neuropathies. The expression of HLA-DR antigen on Schwann cells does not appear to be related to the inflammatory or autoimmune origin of the disease.
authors.affiliation: Institute of Clinical Neurology, University of Genoa, Italy.
authors.forename: G L
authors.initials: GL
authors.lastname: Mancardi
authors.forename: A
authors.initials: A
authors.lastname: Cadoni
authors.forename: A
authors.initials: A
authors.lastname: Zicca
authors.forename: A
authors.initials: A
authors.lastname: Schenone
authors.forename: M
authors.initials: M
authors.lastname: Tabaton
authors.forename: I
authors.initials: I
authors.lastname: De Martini
authors.forename: D
authors.initials: D
authors.lastname: Zaccheo
mesh_terms: D000911:Antibodies, Monoclonal; D006681:HLA-D Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000276:immunology* / Q000473:pathology; D012583:Schwann Cells / Q000276:immunology* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D006681:HLA-D Antigens; D006684:HLA-DR Antigens