title: MR findings in methotrexate-induced CNS abnormalities.
abstract: MR of the brain was performed in eight patients (mean age, 14.9 years) with osteogenic sarcoma during or after IV treatment with high-dose methotrexate. MR detected brain abnormalities in four patients, three of whom had concomitant neurologic dysfunction. Pathologic findings demonstrated on MR were (1) chronic brain edema, demonstrable over a period of 3-14 months (proved by autopsy in one patient); (2) multifocal white matter necrosis; and (3) deep brain atrophy. MR appears to be valuable in the detection of abnormalities induced by treatment with high-dose methotrexate.
authors.affiliation: Department of Radiology, Karl-Franzens-University Graz, Medical School, Austria.
authors.forename: F
authors.initials: F
authors.lastname: Ebner
authors.forename: G
authors.initials: G
authors.lastname: Ranner
authors.forename: I
authors.initials: I
authors.lastname: Slavc
authors.forename: C
authors.initials: C
authors.lastname: Urban
authors.forename: R
authors.initials: R
authors.lastname: Kleinert
authors.forename: H
authors.initials: H
authors.lastname: Radner
authors.forename: R
authors.initials: R
authors.lastname: Einspieler
authors.forename: E
authors.initials: E
authors.lastname: Justich
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D012516:Osteosarcoma / Q000188:drug therapy
chemical_list: D008727:Methotrexate