Studies on the role of leukotrienes in murine allergic and irritant contact dermatitis.
A specific peptidoleukotriene receptor antagonist, Ro 23-3544, was tested for its efficacy in modulating DNFB-induced allergic and croton oil-induced irritant contact dermatitis in mouse ears. Treatment shortly after elicitation of the dermatitis, and for up to 5 days thereafter, was moderately effective in suppressing DNFB-induced ear swelling in a dose-dependent fashion. Daily pre-treatment of the ears for 1 week caused a more marked reduction of DNFB-induced ear swelling during the first 48 h after elicitation. No reduction, but rather an increase in ear swelling was observed with croton oil-induced dermatitis. These results indicate that peptidoleukotrienes play a role in the early stages of elicitation of murine allergic, but not irritant contact dermatitis and that a specific receptor antagonist can only partially reverse the effect of peptidoleukotrienes once the dermatitis is established.
Rosenbach
T
T
Department of Dermatology, University Clinics, Münster, West Germany.
Csatò
M
M
Czarnetzki
B M
BM
D000818:Animals; D001578:Benzopyrans / Q000627:therapeutic use*; D003436:Croton Oil; D003877:Dermatitis, Contact / Q000188:drug therapy* / Q000378:metabolism; D004139:Dinitrofluorobenzene; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D018077:Receptors, Leukotriene; D011982:Receptors, Prostaglandin / Q000187:drug effects*; D013189:SRS-A / Q000037:antagonists & inhibitors*
D001578:Benzopyrans; D018077:Receptors, Leukotriene; D011982:Receptors, Prostaglandin; D013189:SRS-A; C053877:ablukast; D003436:Croton Oil; D004139:Dinitrofluorobenzene