title: Clinical isolate of Citrobacter freundii highly resistant to new quinolones.
abstract: About 30% of 150 recent clinical isolates of Citrobacter freundii were resistant to greater than or equal to 3.13 micrograms of norfloxacin and ofloxacin per ml. Study of one quinolone-resistant strain for which the norfloxacin MIC was 100 micrograms/ml suggested that resistance was associated with both an altered A subunit of DNA gyrase and reduction in drug uptake accompanied by a decrease in an outer membrane protein.
authors.affiliation: Episome Institute, Gunma, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Aoyama
authors.forename: K
authors.initials: K
authors.lastname: Fujimaki
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Fujii
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: S
authors.initials: S
authors.lastname: Mitsuhashi
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism; D002954:Citrobacter / Q000187:drug effects* / Q000235:genetics; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D004352:Drug Resistance, Microbial; D004591:Electrophoresis, Polyacrylamide Gel; D011804:Quinolines / Q000494:pharmacology*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D011804:Quinolines; D004250:DNA Topoisomerases, Type II