The histology of the eye after zosteriform spread of herpes simplex virus in the mouse.
A murine model of zosteriform spread of herpes simplex virus to the eye is reported. Viral antigens were demonstrated by a peroxidase-antiperoxidase technique in the trigeminal ganglion, iris, ciliary body, and cornea. The histology suggested a spontaneous bacterial superinfection during the later stages of the herpetic disease of the cornea. The relevance to human disease is discussed.
Claoue
C
C
Department of Ophthalmology, University of Bristol, Medical School, UK.
Hodges
T
T
Hill
T
T
Blyth
W
W
Easty
D
D
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002924:Ciliary Body / Q000473:pathology; D003315:Cornea / Q000473:pathology; D004195:Disease Models, Animal; D005123:Eye / Q000276:immunology / Q000473:pathology*; D007498:Iris / Q000473:pathology; D007635:Keratitis, Dendritic / Q000276:immunology / Q000473:pathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018139:Simplexvirus / Q000276:immunology; D013997:Time Factors; D014276:Trigeminal Nerve / Q000473:pathology
D000956:Antigens, Viral