Stimulus-secretion coupling in angiotensin-stimulated adrenal glomerulosa cells.
Adrenal glomerulosa cell is a suitable model for a comparative study of signal transducing mechanisms since its secretory activity is regulated by at least three different mechanisms: the adenylate cyclase-cAMP system (for ACTH), the voltage-dependent Ca2+ channel (for K+ and perhaps for angiotensin II) and the inositol 1,4,5-trisphosphate-Ca2+ system (for angiotensin II and vasopressin). The role of inositol phosphates, extracellular Ca2+ and protein kinase C in the induction and sustaining of aldosterone production by cells exposed to angiotensin II is critically reviewed.
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Department of Physiology, Semmelweis University Medical School, Budapest, Hungary.
D000311:Adrenal Glands / Q000378:metabolism*; D000450:Aldosterone / Q000378:metabolism*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D010716:Phosphatidylinositols / Q000502:physiology; D011493:Protein Kinase C / Q000502:physiology
D010716:Phosphatidylinositols; D000804:Angiotensin II; D000450:Aldosterone; D011493:Protein Kinase C; D019204:GTP-Binding Proteins; D002118:Calcium