Interruption of growth signal transduction by an antiviral and antitumoral xanthate compound.
The binding of growth factors to the cellular receptors elicits the phosphorylation of proteins which transmit growth signals to the nucleus [E. Rozengurt (1986) Science 234, 161-166]. Both the tyrosine-specific kinase (growth factor receptor) and the threonine-serine phosphorylating protein kinase C (pkC) become activated upon binding of the epidermal growth factor (EGF) to its receptor. Here we describe the selective inhibition of the pkC activation by tricyclodecane-9-yl-xanthogenate (D609) in the presence of unsuppressed receptor tyrosine autophosphorylation. As a consequence the affinity of EGF to the receptor was not down-regulated and the complex failed to be internalized.
Müller-Decker
K
K
Institute for Virus Research, German Cancer Research Center, Heidelberg.
Doppler
C
C
Amtmann
E
E
Sauer
G
G
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D002478:Cells, Cultured; D066246:ErbB Receptors / Q000032:analysis; D005347:Fibroblasts / Q000201:enzymology; D009636:Norbornanes; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D013859:Thiocarbamates; D013871:Thiones / Q000494:pharmacology*
D000998:Antiviral Agents; D001952:Bridged-Ring Compounds; D009636:Norbornanes; D013859:Thiocarbamates; D013871:Thiones; C046498:tricyclodecane-9-yl-xanthogenate; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases; D011493:Protein Kinase C