title: Sulfur oxidation of free methionine by oxygen free radicals.
abstract: The oxidation of free methionine to methionine sulfoxide by chemically or enzymatically generated oxygen free radicals is presented. The physiological significance of this process in living cells is suggested.
authors.affiliation: Department of Biochemistry, Indiana University School of Medicine, Indianapolis 46223.
authors.forename: P W
authors.initials: PW
authors.lastname: Scislowski
authors.forename: E J
authors.initials: EJ
authors.lastname: Davis
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D005609:Free Radicals; D008715:Methionine / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000378:metabolism; D009211:Myoglobin / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D013455:Sulfur / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D005609:Free Radicals; D009211:Myoglobin; C017595:oxymyoglobin; D009243:NAD; D013481:Superoxides; D013455:Sulfur; D008715:Methionine; D002374:Catalase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D010100:Oxygen; C013111:methionine sulfoxide