Adrenalectomy and the anorectic effects of benzodiazepine inverse agonists and opiate antagonists in rats fed a palatable diet.
The benzodiazepine (BZ) receptor inverse agonists, FG 7142 (1.25-10.0 mg/kg, IP) and CGS 8216 (2.5-20.0 mg/kg, IP), significantly attenuated the consumption of a palatable sweetened diet by non-deprived male rats in a 30 min test. Adrenalectomy failed to affect the reduction in food intake produced by these two drugs. Similarly, the anorectic effects of the opiate antagonists, naltrexone (0.3-3.0 mg/kg, SC) and diprenorphine (0.3-3.0 mg/kg, SC) in the same feeding paradigm were unaffected by adrenalectomy. So far as palatability-induced feeding in concerned, anorectic effects of BZ inverse agonists and opiate-antagonists appear to be adrenal-independent in the rat. The benzodiazepines, clonazepam (0.3 mg/kg, IP) and diazepam (1.0 mg/kg, IP), stimulated food consumption in both adrenalectomized and sham-operated animals.
Cooper
S J
SJ
Kirkham
T C
TC
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001067:Appetite Depressants / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology*; D002998:Clonazepam / Q000494:pharmacology; D004174:Diprenorphine / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects; D006815:Hunger / Q000187:drug effects*; D008297:Male; D009019:Morphinans / Q000494:pharmacology*; D009271:Naltrexone / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects*; D013649:Taste / Q000187:drug effects
D001067:Appetite Depressants; D002243:Carbolines; D009019:Morphinans; D011720:Pyrazoles; D011963:Receptors, GABA-A; D004174:Diprenorphine; D002998:Clonazepam; D009271:Naltrexone; C035874:FG 7142; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one