Enhancement of mitochondrial tyrosine kinase activity following viral transformation.
A tyrosine protein kinase activity has been detected in the mitochondrial fraction purified from normal and virus-transformed cultured cells. The addition of serum to cells whose growth was restricted by serum limitation induced a marked decrease of tyrosine kinase activity associated with the mitochondrial fraction. At all the culture conditions tested this enzyme activity always resulted several fold higher in the virus-transformed cells than in the normal parental cells.
Piedimonte
G
G
Istituto di Patologia Generale, Università di Parma, Italy.
Silvotti
L
L
Borghetti
A F
AF
Montagnier
L
L
D000818:Animals; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D003470:Culture Media; D008928:Mitochondria / Q000201:enzymology*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D013539:Simian virus 40
D003470:Culture Media; D011505:Protein-Tyrosine Kinases