Higher density of 125I-neuropeptide Y receptors in the area postrema of SHR.
125I-Neuropeptide Y (125I-NPY) binding capacities were quantitated in the areas postrema of young (5 weeks) and adult (20 week SHR and compared with age-matched WKY rats using autoradiography. The maximum binding capacity (Bmax) was significantly higher in the area postrema of adult SHR, while no difference was seen at the age of 5 weeks. Our result supports the idea of a functional role for NPY receptors in the central control of blood pressure. NPY receptors in the area postrema may be involved in the perception of circulating NPY resulting in the alteration of the neuronal activity of the nucleus tractus solitarii.
Nakajima
T
T
Department of Pharmacology, Nippon Roche Research Center, Kanagawa, Japan.
Yashima
Y
Y
Nakamura
K
K
D000367:Age Factors; D000818:Animals; D001345:Autoradiography; D001794:Blood Pressure; D002552:Cerebral Ventricles / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D017476:Receptors, Neuropeptide Y; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y; D017981:Receptors, Neurotransmitter