[Role of the peripheral catecholaminergic systems in the antistress action of neuropeptides].
The mediator activity of the peripheral catecholaminergic systems (the adrenergic nerves of dura mater and the concentrations of noradrenaline and adrenaline in the adrenals of rats) during dynamic and immobilization stress was investigated with the help of fluorescent microscopy and spectrofluorometry. Neuropeptides--dalargin and another enkephalin analog--were injected intraperitoneally, 150 mg/kg. A visible antistress action of these neuropeptides has been demonstrated, it was more marked after treatment with dalargin. The role of peripheral catecholaminergic system in the mechanism of stress-protective effects of neuropeptides is discussed.
Khaĭsman
E B
EB
Arefolov
V A
VA
Malikova
L A
LA
D000313:Adrenal Medulla / Q000187:drug effects / Q000294:innervation; D000320:Adrenergic Fibers / Q000187:drug effects; D000818:Animals; D002395:Catecholamines / Q000502:physiology*; D004353:Drug Evaluation, Preclinical; D004388:Dura Mater / Q000187:drug effects; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D004745:Enkephalins / Q000627:therapeutic use; D008297:Male; D009479:Neuropeptides / Q000627:therapeutic use*; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D017983:Receptors, Catecholamine; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000517:prevention & control*; D013997:Time Factors
D002395:Catecholamines; D004745:Enkephalins; D009479:Neuropeptides; D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Rol' perifericheskikh katekholaminergicheskikh sistem v antistressovom deĭstvii neĭropeptidov.