title: Subacute sensory neuronopathy associated with small cell lung carcinoma: diagnosis aided by autoimmune serology.
abstract: In two patients with subacute sensory neuronopathy associated with small cell carcinoma of the lung, the diagnosis of the paraneoplastic syndrome was aided by the finding, in highly diluted serum (1/500 and 1/2,000, respectively), of unusual and distinctive antinuclear antibodies with reactivity restricted to neuronal nuclei. Magnetic resonance imaging of the chest was instrumental in detecting both lung cancers.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN 55905.
authors.forename: D W
authors.initials: DW
authors.lastname: Kimmel
authors.forename: B P
authors.initials: BP
authors.lastname: O'Neill
authors.forename: V A
authors.initials: VA
authors.lastname: Lennon
mesh_terms: D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis*; D000912:Antibodies, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000276:immunology*; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology / Q000276:immunology*; D012677:Sensation
chemical_list: D000974:Antibodies, Antinuclear; D000912:Antibodies, Neoplasm; D014408:Biomarkers, Tumor