[Cytogenetic effect of iodized radiocontrast media in human blood lymphocytes].
Triombrast (60%) iodamide-380, free verografin and verografin incorporated in liposomes in commonly used amounts produce no significant cytogenetic effect on peripheral blood lymphocytes. An increase in the concentration of these drugs results in a decrease in the lymphocytic mitotic index and structural chromosomal disorders which are marked at the most in a 10- and 20-fold increase in a clinical dose.
Amosov
I S
IS
Izmaĭlova
N N
NN
Nikitina
R G
RG
D000328:Adult; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003287:Contrast Media / Q000633:toxicity*; D003974:Diatrizoate Meglumine / Q000008:administration & dosage / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D006801:Humans; D007459:Iodized Oil / Q000633:toxicity*; D008081:Liposomes; D008214:Lymphocytes / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects
D003287:Contrast Media; D004337:Drug Carriers; D008081:Liposomes; D003974:Diatrizoate Meglumine; D007459:Iodized Oil
Tsitogeneticheskiĭ éffekt ĭodirovannykh rentgenokontrastnykh sredstv v limfotsitakh krovi cheloveka.