title: [Determination of haplotypes of DNA markers linked to the mucoviscidosis locus: detection of heterozygotes].
abstract: Linked DNA probes have been used in three families presenting an affected child with cystic fibrosis. The strategy used for the determination of haplotypes associated with parental normal and mutated genes is presented as well as its application to the detection of cystic fibrosis carriers among healthy children.
authors.affiliation: Service de Génétique, Faculté de Médecine, Lille.
authors.forename: F
authors.initials: F
authors.lastname: Vasseur
authors.forename: F
authors.initials: F
authors.lastname: Fontaine
authors.forename: J B
authors.initials: JB
authors.lastname: Savary
authors.forename: M M
authors.initials: MM
authors.lastname: Deminatti
mesh_terms: D002648:Child; D002874:Chromosome Mapping; D003550:Cystic Fibrosis / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D004262:DNA Restriction Enzymes / Q000032:analysis; D005260:Female; D006580:Genetic Carrier Screening; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D008297:Male; D010375:Pedigree
chemical_list: D005819:Genetic Markers; D004247:DNA; D004262:DNA Restriction Enzymes
vernacular_title: Etablissement des haplotypes des marqueurs d'ADN proches du locus de la mucoviscidose: détection des hétérozygotes.