Frequent involvement of the fim-3 region in Friend murine leukemia virus-induced mouse myeloblastic leukemias.
fim-3 is a new proviral integration region involved in 23% (16 of 68) of Friend murine leukemia virus-induced myeloblastic leukemias. This region is distinct from 20 oncogenes and from putative oncogenes tested so far. Proviruses are integrated in a 16-kilobase region, always in the same orientation. No RNA expression of fim-3 was detected.
Bordereaux
D
D
Laboratoire Immunologie et Virologie des Tumeurs, Institut National de la Santé et de la Recherche Médicale, Paris, France.
Fichelson
S
S
Sola
B
B
Tambourin
P E
PE
Gisselbrecht
S
S
D000818:Animals; D002460:Cell Line; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000235:genetics; D005622:Friend murine leukemia virus / Q000235:genetics*; D005814:Genes, Viral; D007942:Leukemia, Experimental / Q000382:microbiology*; D015470:Leukemia, Myeloid, Acute / Q000382:microbiology; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D011533:Proviruses / Q000235:genetics*
D004279:DNA, Viral; D004262:DNA Restriction Enzymes