title: Second messengers involved in superoxide production by neutrophils. Function and metabolism.
abstract: The second messengers that initiate superoxide production by phagocytic leukocytes are reviewed with emphasis on the interactions of these compounds. Enzymes that control the production of the messengers are described.
authors.affiliation: Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts.
authors.forename: K L
authors.initials: KL
authors.lastname: Sadler
authors.forename: J A
authors.initials: JA
authors.lastname: Badwey
mesh_terms: D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D004075:Diglycerides / Q000096:biosynthesis / Q000378:metabolism*; D005989:Glycerides / Q000378:metabolism*; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000096:biosynthesis / Q000378:metabolism; D015544:Inositol 1,4,5-Trisphosphate; D007295:Inositol Phosphates / Q000378:metabolism*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D019255:NADPH Oxidases; D009504:Neutrophils / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D010101:Oxygen Consumption; D011493:Protein Kinase C / Q000378:metabolism / Q000502:physiology; D013403:Sugar Phosphates / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism*; D010738:Type C Phospholipases / Q000378:metabolism
chemical_list: D004075:Diglycerides; D005989:Glycerides; D006893:Hydroxyeicosatetraenoic Acids; D007295:Inositol Phosphates; D013403:Sugar Phosphates; D013481:Superoxides; C022022:5-hydroxy-6,8,11,14-eicosatetraenoic acid; D015544:Inositol 1,4,5-Trisphosphate; D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases; D011493:Protein Kinase C; D010738:Type C Phospholipases; D002118:Calcium