title: Binding of C-terminal segments of neuropeptide Y to chicken brain.
abstract: The C-terminal pentapeptide amide segment of neuropeptide Y (NPY) binds specifically to chicken brain membrane preparations. The contribution of each residue of the C-terminus to this binding has been investigated through the synthesis and evaluation of a series of pentapeptide analogs. The binding of these molecules is strongly dependent on the presence of certain functional groups, in particular the guanidinium group of Arg-35 and the C-terminal aromatic amide function. The significance of these results for the binding to chicken brain tissue of NPY, pancreatic polypeptide and other potentially related neuropeptides is discussed.
authors.affiliation: Department of Chemistry, University of Houston, Texas.
authors.forename: M O
authors.initials: MO
authors.lastname: Perlman
authors.forename: J M
authors.initials: JM
authors.lastname: Perlman
authors.forename: M L
authors.initials: ML
authors.lastname: Adamo
authors.forename: R L
authors.initials: RL
authors.lastname: Hazelwood
authors.forename: D F
authors.initials: DF
authors.lastname: Dyckes
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D002645:Chickens; D007202:Indicators and Reagents; D007700:Kinetics; D009478:Neuropeptide Y / Q000378:metabolism*; D009842:Oligopeptides / Q000138:chemical synthesis*; D010446:Peptide Fragments / Q000378:metabolism; D017476:Receptors, Neuropeptide Y; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D007202:Indicators and Reagents; D009478:Neuropeptide Y; D009842:Oligopeptides; D010446:Peptide Fragments; D017476:Receptors, Neuropeptide Y; D017981:Receptors, Neurotransmitter