L-652,343, a novel dual cyclo/lipoxygenase inhibitor, inhibits LTB4-production by stimulated human polymorphonuclear cells but not by stimulated human whole blood.
Gresele
P
P
Centre for Thrombosis and Vascular Research, University of Leuven, Belgium.
Arnout
J
J
Deckmyn
H
H
Vermylen
J
J
D000001:Calcimycin / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors; D006801:Humans; D007975:Leukotriene B4 / Q000096:biosynthesis*; D016859:Lipoxygenase Inhibitors; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D013876:Thiophenes / Q000494:pharmacology*; D013929:Thromboxane B2 / Q000096:biosynthesis
D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D013876:Thiophenes; C051277:L 652343; D007975:Leukotriene B4; D000001:Calcimycin; D013929:Thromboxane B2