Lack of effectiveness of forskolin or inositol as antidote in lithium toxicity. Short note.
Forskolin, a direct adenylate cyclase stimulator, was suggested as a possible antidote to lithium toxicity, since lithium inhibits cyclic AMP accumulation. Inositol, a sugar isomer reduced in lithium treatment due to inhibition of inositol-1-phosphatase, was suggested as a possible antidote to lithium toxicity. Both were ineffective in a mouse model.
Kaplan
Z
Z
Ida and Solomon Stern Psychiatric Research Unit, Beer Sheva Mental Health Center, Israel.
Schreiber
G
G
Belmaker
R H
RH
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002712:Chlorides / Q000633:toxicity*; D005576:Colforsin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D007294:Inositol / Q000627:therapeutic use*; D008094:Lithium / Q000633:toxicity*; D018021:Lithium Chloride; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D000931:Antidotes; D002712:Chlorides; D005576:Colforsin; D007294:Inositol; D008094:Lithium; D018021:Lithium Chloride