Cross-reaction between aromatic isocyanates (TDI and MDI): a specific bronchial provocation test study.
A study was performed on twenty-five workers exposed to polyurethane varnishes exclusively catalysed with TDI, who developed asthma to this substance. The aim of the study was to establish, using bronchial provocation tests, whether a cross-response to MDI exists. The results were positive but no definitive evidence has been reached because there was cross-response in only 48% of cases. It is interesting, however, that cross-responders did not predominate among the subjects with a late reaction to TDI (P = 0.0038), whereas cross-responders were in the majority among the subjects with a dual reaction to TDI (P = 0.0334). It is possible that the pattern of the asthmatic reaction to BPT with TDI influences the cross-reaction to other isocyanates.
Innocenti
A
A
Institute of Occupational Health, University of Siena, Italy.
Cirla
A M
AM
Pisati
G
G
Mariano
A
A
D000328:Adult; D001249:Asthma / Q000139:chemically induced / Q000276:immunology; D001985:Bronchial Provocation Tests / Q000379:methods*; D003429:Cross Reactions; D003485:Cyanates / Q000276:immunology*; D005260:Female; D006801:Humans; D017953:Isocyanates; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000276:immunology; D011140:Polyurethanes / Q000009:adverse effects; D014051:Toluene 2,4-Diisocyanate / Q000276:immunology*; D001559:Benzhydryl Compounds
D003485:Cyanates; D017953:Isocyanates; D011140:Polyurethanes; D014051:Toluene 2,4-Diisocyanate; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds