title: Aberrant growth of mossy fibers and enhanced kainic acid binding sites induced in rats by early hyperthyroidism.
abstract: Early hyperthyroidism induces an aberrant growth of hippocampal mossy fibers both in the fascia dentata (supragranular layer) and in Ammon's horn (infrapyramidal layer of CA3). Using a quantitative autoradiographic method, we found a corresponding increase in kainic acid binding sites supporting previous observations of a very close association between mossy fiber terminals and kainic acid binding sites.
authors.affiliation: INSERM U29, Laboratoire de Neurobiologie et Physiopathologie du Développement, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Represa
authors.forename: E
authors.initials: E
authors.lastname: Tremblay
authors.forename: Y
authors.initials: Y
authors.lastname: Ben-Ari
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D006980:Hyperthyroidism / Q000378:metabolism / Q000473:pathology*; D007608:Kainic Acid / Q000378:metabolism*; D008297:Male; D011712:Pyramidal Tracts / Q000378:metabolism / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D018092:Kainic Acid Receptors; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013974:Thyroxine / Q000494:pharmacology
chemical_list: D007608:Kainic Acid; D018092:Kainic Acid Receptors; D017981:Receptors, Neurotransmitter; D013974:Thyroxine