[Biochemical effects of ryodipine (foridon)--a new calcium antagonist and derivative of 1,4-dihydopyridine].
Ryodipine (foridon)--2, 6-dimethyl-3,5-dicarbomethoxy-4-(o-difluoromethoxyphenyl)-1, 4-dihydropyridine--similarly to nifedipine but at a lesser degree than nicardipine causes an increase of cAMP concentration in the slices of the rabbit myocardium and aorta. This property of 1,4-dihydropyridines is reflected in their effect on the uptake of 45Ca2+ by the myocardial strips. In the range of concentrations of 10(-4)-10(-6)M inhibition of 45Ca2+ transport is enhanced with a decrease of concentrations of the drugs. Under inactivation of potential-dependent transport of Ca2+, 1,4-dihydropyridines enhance the uptake of 45Ca2+. The similar effect was found at incubation of the myocardial slices in a polarizing buffer (2.68 mM K+). Verapamil, irrespective of the degree of depolarization (60,123 mM K+), suppressed in a linear dependence the uptake of 45Ca2+ and failed to influence this process in the absence of potential-dependent transport of Ca2+. By its biochemical effects ryodipine does not differ from the known derivatives of 1,4-dihydropyridine but has, like nifedipine and nicardipine, significant differences as compared with verapamil.
Simkhovich
B Z
BZ
Mezhapuke
R Ia
RIa
Dubur
G Ia
GIa
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006352:Heart Ventricles / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D009529:Nicardipine / Q000494:pharmacology; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D014700:Verapamil; D009529:Nicardipine; D000242:Cyclic AMP; D009543:Nifedipine; D002118:Calcium; C045912:ryodipine
Izuchenie biokhimicheskikh éffektov riodipina (foridona)--novogo antagonista kal'tsiia, proizvodnogo 1,4-digidropiridina.