title: [Neuroendocrine rhythms in uni- and bipolar depressions].
abstract: Eighteen patients with major depressive disorder of the endogenous subtype (8 unipolars and 10 bipolars) were submitted to blood sampling at 15 min interval for 24 h with polygraphic sleep recording during an acute episode of depression. Plasma growth hormone (GH), adrenocorticotrophin (ACTH) and cortisol were measured in each sample. The depressed patients hypersecreted GH during the daytime and had hypercortisolism which was evident throughout the 24 h span. The nadir of ACTH and cortisol rhythms was advanced by an average of 3 h as compared to the timing observed in normal subjects. These abnormalities were more pronounced and more consistent in patients with unipolar rather than bipolar depression. These results are consistent with the hypothesis that disorders of circadian time-keeping may characterize major endogenous depression.
authors.affiliation: Service de psychiatrie, Hôpital Erasme, Université libre de Bruxelles, Belgique.
authors.forename: P
authors.initials: P
authors.lastname: Linkowski
authors.forename: E
authors.initials: E
authors.lastname: Van Cauter
authors.forename: M
authors.initials: M
authors.lastname: Kerkhofs
authors.forename: P
authors.initials: P
authors.lastname: Hubain
authors.forename: M
authors.initials: M
authors.lastname: Brasseur
authors.forename: R
authors.initials: R
authors.lastname: Leclercq
authors.forename: J
authors.initials: J
authors.lastname: Golstein
authors.forename: G
authors.initials: G
authors.lastname: Copinschi
authors.forename: J
authors.initials: J
authors.lastname: Mendlewicz
mesh_terms: D000305:Adrenal Cortex Hormones / Q000097:blood*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D001714:Bipolar Disorder / Q000097:blood*; D002940:Circadian Rhythm; D003866:Depressive Disorder / Q000097:blood*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D012890:Sleep / Q000502:physiology
chemical_list: D000305:Adrenal Cortex Hormones; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D006854:Hydrocortisone
vernacular_title: Rythmes neuroendocriniens dans les dépressions uni- et bipolaires.