title: HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes.
abstract: The human T-cell leukemia virus (HTLV) types I and II have two nonstructural genes that are encoded in overlapping reading frames. One of these genes, known as tax, has been shown to encode a protein responsible for enhanced transcription (transactivation) from the viral long terminal repeats (LTRs). Genetic evidence indicates that the second nonstructural gene of HTLV-II, here designated rex, acts in trans to modulate tax gene-mediated transactivation in a concentration-dependent fashion. The rex gene may regulate the process of transactivation during the viral life cycle.
authors.affiliation: Department of Medicine, UCLA School of Medicine.
authors.forename: J D
authors.initials: JD
authors.lastname: Rosenblatt
authors.forename: A J
authors.initials: AJ
authors.lastname: Cann
authors.forename: D J
authors.initials: DJ
authors.lastname: Slamon
authors.forename: I S
authors.initials: IS
authors.lastname: Smalberg
authors.forename: N P
authors.initials: NP
authors.lastname: Shah
authors.forename: J
authors.initials: J
authors.lastname: Fujii
authors.forename: W
authors.initials: W
authors.lastname: Wachsman
authors.forename: I S
authors.initials: IS
authors.lastname: Chen
mesh_terms: D001483:Base Sequence; D004274:DNA, Recombinant; D004279:DNA, Viral / Q000235:genetics; D017977:Deltaretrovirus / Q000235:genetics*; D005809:Genes, Regulator; D005814:Genes, Viral; D009154:Mutation; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D013539:Simian virus 40 / Q000235:genetics; D014158:Transcription, Genetic; D014162:Transfection
chemical_list: D004274:DNA, Recombinant; D004279:DNA, Viral; D012333:RNA, Messenger; D012367:RNA, Viral