Effects of pantoyl-GABA on GABAA and GABAB receptors in the rat brain.
The interactions of the "antidementia drug" pantoyl-gamma-aminobutyric acid (pantoyl-GABA) with gamma-aminobutyric acid (GABA) receptors were investigated by studies on bindings of radiolabelled ligands in rat brain. Pantoyl-GABA inhibited the binding of [3H]GABA to GABAA receptors and those of [3H]baclofen and [3H]GABA to GABAB receptors in the rat cerebral cortex. These data suggest that pantoyl-GABA interacts with both types of GABA-receptors in the rat brain.
Nakahiro
M
M
Department of Pharmacology I, Osaka University School of Medicine, Japan.
Nishi
N
N
Fukuchi
I
I
Mochizuki
D
D
Kato
S
S
Mizushima
A
A
Uchida
S
S
Yoshida
H
H
D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000145:classification / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology
D011963:Receptors, GABA-A; C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid; D002118:Calcium