Regulation of carcinogens in terms of life shortening.
Because of the difficulty in using the results of conventional quantitative risk assessment in the regulation of carcinogens, an approach to setting carcinogen standards is presented based on the reduction of cancer-induced life span shortening to statistically nonsignificant levels. An argument is made that the time of cancer occurrence is more important than the risk of cancer. The rationale is that the objective of carcinogen control is to delay the single-risk time of cancer occurrence. Whether this benefit is associated with a decrease, increase or no change in the risk of dying of cancer depends on concomitant changes in the temporal pattern of other causes of death. For indispensable carcinogens the permissible exposure is the level which shortens the time to background cancer by an amount equal to the uncertainty in the time of background cancer occurrence. This approach is illustrated by the use of the ED01 2-FAA bioassay on mice.
Albert
R E
RE
Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267.
Shukla
R
R
D000818:Animals; D015197:Carcinogenicity Tests; D002274:Carcinogens, Environmental; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008136:Longevity / Q000187:drug effects*; D008452:Maximum Allowable Concentration; D012306:Risk
D002274:Carcinogens, Environmental