Restricted heterogeneity of antibody to gp120 and p24 in AIDS.
Neurologic complications and cerebrospinal fluid (CSF) abnormalities are common in AIDS. We found that a substantial number of AIDS patients with neurologic involvement had oligoclonal IgG bands in CSF and sera by IEF. Using an IEF-Ag overlay technique, anti-gp120 antibody activity was demonstrated more frequently than anti-p24 antibody activity. These antibody activities exhibited restricted heterogeneity of their IEF pattern; this restriction may contribute to the relatively low titers of neutralizing antibody found in AIDS sera. None of the CSF and serum oligoclonal bands showed anti-HIV antibody activity, suggesting that they are directed against opportunistic agents or result from immunodysregulation.
Grimaldi
L M
LM
Abbott Laboratories, North Chicago, IL 60064.
Roos
R P
RP
Devare
S G
SG
Robey
W G
WG
Casey
J M
JM
Gurney
M E
ME
Apatoff
B R
BR
Lazzarin
D
D
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D000914:Antibodies, Viral / Q000302:isolation & purification* / Q000502:physiology; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D003704:Dementia / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies; D016655:HIV Core Protein p24; D015699:HIV Envelope Protein gp120; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D012191:Retroviridae Proteins / Q000276:immunology*; D012709:Serum Albumin / Q000134:cerebrospinal fluid
D000914:Antibodies, Viral; D015483:HIV Antibodies; D016655:HIV Core Protein p24; D015699:HIV Envelope Protein gp120; D007074:Immunoglobulin G; D012191:Retroviridae Proteins; D012709:Serum Albumin