title: Antibacterial characteristics of YTR 830, a sulfone beta-lactamase inhibitor, compared with those of clavulanic acid and sulbactam.
abstract: The antibacterial activity, binding to penicillin-binding proteins, and morphological changes effected by YTR 830, a sulfone beta-lactamase inhibitor, were studied in comparison with those of other beta-lactamase inhibitors. YTR 830 had very poor antibacterial activity, bound to PBP 2 of gram-negative organisms, and at the MIC caused rapid lysis of spheroplasts formed.
authors.affiliation: Department of Medical Microbiology, London Hospital Medical College, England.
authors.forename: F
authors.initials: F
authors.lastname: Moosdeen
authors.forename: J D
authors.initials: JD
authors.lastname: Williams
authors.forename: S
authors.initials: S
authors.lastname: Yamabe
mesh_terms: D001419:Bacteria / Q000187:drug effects* / Q000648:ultrastructure; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000378:metabolism; D002969:Clavulanic Acids / Q000494:pharmacology*; D006602:Hexosyltransferases; D008826:Microbial Sensitivity Tests; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism; D010397:Penicillanic Acid / Q000494:pharmacology*; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D013407:Sulbactam / Q000494:pharmacology*; D000078142:Tazobactam; D065093:beta-Lactamase Inhibitors
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D002969:Clavulanic Acids; D046915:Penicillin-Binding Proteins; D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D013407:Sulbactam; D000078142:Tazobactam