Suppression of humoral antibody formation against sheep red blood cells by infections with HSV-2 and the influence of mouse cytomegalovirus. Brief report.
HSV-2 infections suppress the antibody response to HSV-1 but do not impair the mouse cytomegalo virus (MCMV) antibody generating system. In contrast, the sheep red blood cell (SRBC) IgM response is impaired by preinfections with HSV-2 but not with HSV-1. From the time kinetics of this suppression it can be concluded that only a certain submechanism "spills over" to the SRBC system. MCMV suppresses the antibody formation induced by HSV-1.
Nick
S
S
Division of Experimental Virology, Johannes Gutenberg-University, Mainz, Federal Republic of Germany.
Metzger
B
B
Jonsić
S
S
Falke
D
D
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000917:Antibody Formation; D003587:Cytomegalovirus / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D006561:Herpes Simplex / Q000276:immunology*; D007108:Immune Tolerance; D007075:Immunoglobulin M / Q000096:biosynthesis; D051379:Mice; D018139:Simplexvirus / Q000276:immunology; D013997:Time Factors
D000914:Antibodies, Viral; D007075:Immunoglobulin M