Nourseothricin (streptothricin) inactivated by a plasmid pIE636 encoded acetyl transferase: nature of the inactivated nourseothricin.
Nourseothricin, a mixture of several streptothricins, is inactivated by an acetyl transferase produced by Escherichia coli containing the plasmid pIE636. Nourseothricin inactivated in the presence of 14C-acetate was purified and submitted to partial hydrolysis. In the hydrolysate besides others a radioactive and ninhydrin-reactive substance moving only slightly towards the cathode was found. It proved to be [14C]-acetyl beta-lysine.
Seltmann
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Beer
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D000107:Acetylation; D000123:Acetyltransferases / Q000235:genetics / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli; D010957:Plasmids; D013309:Streptothricins / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D013309:Streptothricins; D000123:Acetyltransferases