title: Cytogenetic investigations of patients on clodronate therapy for Paget's disease of bone.
abstract: In order to judge whether or not clodronate used for treatment of patients with Paget's disease of bone had an effect on the haematopoetic tissue, the frequency of chromosome/chromatid breaks in bone marrows and blood cells was evaluated. Seven patients were studied before treatment, after a few days of treatment and after greater than or equal to 2 months of treatment. Three additional patients were studied after exposure to clodronate for greater than or equal to 6 months. There was no significant increase in the occurrence of chromosomal aberrations induced by treatment. Thus no negative effect of clodronate on the haematopoetic tissue could be noted.
authors.affiliation: Department of Medical Genetics, University of Helsinki, Finland.
authors.forename: G H
authors.initials: GH
authors.lastname: Borgström
authors.forename: I
authors.initials: I
authors.lastname: Elomaa
authors.forename: C
authors.initials: C
authors.lastname: Blomqvist
authors.forename: L
authors.initials: L
authors.lastname: Porkka
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000187:drug effects*; D002869:Chromosome Aberrations / Q000187:drug effects*; D004002:Clodronic Acid / Q000009:adverse effects*; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000188:drug therapy*
chemical_list: D004164:Diphosphonates; D004002:Clodronic Acid