title: Chromosome size polymorphism in Plasmodium falciparum can involve deletions of the subtelomeric pPFrep20 sequence.
abstract: The P. falciparum pPFrep20 repetitive element from the Palo Alto Uganda strain has been isolated and sequenced. The Palo Alto pPFrep20 repeat (pPFPArep20) has a clustered subtelomeric location and on chromosome 1 has been deleted from one end. Analysis of chromosome 1 from 5 other strains has revealed that pPFrep20 sequences have been deleted from one end in 3 of them. Thus, deletion of pPFrep20 appears to be a frequent event that could significantly contribute to chromosome size polymorphism in P. falciparum.
authors.affiliation: Unit of Experimental Parasitology, Institut Pasteur, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Patarapotikul
authors.forename: G
authors.initials: G
authors.lastname: Langsley
mesh_terms: D000818:Animals; D001483:Base Sequence; D002872:Chromosome Deletion; D002875:Chromosomes / Q000648:ultrastructure*; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification; D004262:DNA Restriction Enzymes; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000235:genetics*; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004247:DNA; D004262:DNA Restriction Enzymes