Activation of inflammatory systems during cardiopulmonary bypass.
"Whole body inflammation" induced by cardiopulmonary bypass may play a role in the pathogenesis of postoperative complications after open-heart surgery. The inflammatory response, in terms of complement activation and release of granular proteins from neutrophil granulocytes, was investigated in six patients undergoing aortocoronary bypass surgery. Complement activation was demonstrated as well as substantially increased plasma levels of lactoferrin and myeloperoxidase--two granulocyte factors. The activation of inflammatory systems probably takes place on the artificial surfaces of the extracorporeal device. The biocompatibility of these components therefore should be further studied.
Nilsson
L
L
Department of Thoracic Surgery, University Hospital, Uppsala, Sweden.
Brunnkvist
S
S
Nilsson
U
U
Nyström
S O
SO
Tydén
H
H
Venge
P
P
Aberg
T
T
D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D003176:Complement C3 / Q000378:metabolism; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000378:metabolism; D007781:Lactoferrin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood
D003176:Complement C3; D009195:Peroxidase; D007781:Lactoferrin