title: Progressive mucocutaneous herpes simplex infection due to acyclovir-resistant virus in an immunocompromised patient: correlation of viral susceptibilities and plasma levels with response to therapy.
abstract: Rapidly progressive disease due to acyclovir-resistant herpes simplex has not been described. We report such a case and detail successful patient management using viral sensitivities and plasma acyclovir levels to guide therapy. Response was correlated with plasma levels above those inhibiting viral growth by 50% (ID50) in vitro.
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota Health Sciences Center, Minneapolis.
authors.forename: B
authors.initials: B
authors.lastname: Bean
authors.forename: C
authors.initials: C
authors.lastname: Fletcher
authors.forename: J
authors.initials: J
authors.lastname: Englund
authors.forename: S N
authors.initials: SN
authors.lastname: Lehrman
authors.forename: M N
authors.initials: MN
authors.lastname: Ellis
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D004352:Drug Resistance, Microbial; D006561:Herpes Simplex / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007635:Keratitis, Dendritic / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D010746:Phosphonoacetic Acid / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects*; D014740:Vidarabine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D014740:Vidarabine; D010746:Phosphonoacetic Acid; D000212:Acyclovir