Hypomagnesemia and bronchial hyperreactivity. A case report.
In a 37-year-old woman, a heavy smoker and an alcoholic, bronchial hyperreactivity to histamine (PC20 FEV1 0.8 mg/ml) was related to hypomagnesemia (0.55 mmol/l). After acute magnesium repletion (24 h i.v. infusion MgSO4 6 g, serum magnesium 1.05 mmol/l), histamine PC20 FEV1 increased up to 9.8 mg/ml. The role of magnesium in modulating smooth muscle contractility is discussed and the importance of checking serum magnesium in patients with airway obstruction is suggested.
Rolla
G
G
Clinica Medica I, University of Torino, Italy.
Bucca
C
C
D000328:Adult; D000402:Airway Obstruction / Q000209:etiology*; D000428:Alcohol Drinking; D001985:Bronchial Provocation Tests / Q000379:methods; D005260:Female; D006632:Histamine / Q000276:immunology; D006801:Humans; D008275:Magnesium Deficiency / Q000150:complications*; D012132:Respiratory Muscles / Q000503:physiopathology; D012135:Respiratory Sounds / Q000175:diagnosis / Q000209:etiology*; D012907:Smoking / Q000009:adverse effects
D006632:Histamine