title: Analysis of methylation of a human X located gene which escapes X inactivation.
abstract: The gene MIC2 is located in the pseudoautosomal region at the ends of the short arms of the X and Y chromosomes. In females MIC2 escapes X inactivation. We have analyzed the methylation pattern of MIC2 on the active X, the inactive X chromosomes, and the Y chromosome. The 5' end of the gene contains a GC rich region which is unmethylated on the active X, the inactive X and on the Y. The body of the gene is characterized by variable methylation.
authors.affiliation: Istituto di Genetica Biochimica ed Evoluzionistica del CNR, Pavia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Mondello
authors.forename: P J
authors.initials: PJ
authors.lastname: Goodfellow
authors.forename: P N
authors.initials: PN
authors.lastname: Goodfellow
mesh_terms: D001483:Base Sequence; D004262:DNA Restriction Enzymes / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007438:Introns; D008745:Methylation; D014960:X Chromosome; D014998:Y Chromosome
chemical_list: D004262:DNA Restriction Enzymes