Bone ingrowth into porous calcium phosphate ceramics: influence of pulsing electromagnetic field.
The effect of a pulsing electromagnetic field (PEMF) on bone ingrowth into porous hydroxyapatite (HA) and porous tricalcium phosphate (TCP) implanted in rabbit tibiae was studied. To quantitate the biological response, a recently developed method of surface measurement using a scanning electron microscope was used. The morphometrical findings in the HA pores demonstrated a significantly greater amount of bone and thicker bone trabeculae in the PEMF group as compared with the nonpulsed control group at 3 to 4 weeks postimplantation. No significant differences for these parameters were found in the TCP pores. Histologically, more bone and wider bone trabeculae were observed in the HA implants for the PEMF-treated animals at the early time periods when compared with those of the control animals. Alternatively, the histological findings of the TCP implants were similar between these two groups. These histological results tended to correlate with the morphometrical data. Together, these results suggest that accelerated bone formation and bone maturation occurred in response to PEMF in the HA pores but was without effect in the TCP pores. This stimulatory effect is most significant after 3-4 weeks of PEMF stimulation.
Shimizu
T
T
Division of Orthopedic Surgery, University of Texas Southwestern Medical School, Dallas.
Zerwekh
J E
JE
Videman
T
T
Gill
K
K
Mooney
V
V
Holmes
R E
RE
Hagler
H K
HK
D000818:Animals; D001846:Bone Development; D002130:Calcium Phosphates; D002516:Ceramics; D017886:Durapatite; D004574:Electromagnetic Fields / Q000379:methods*; D055590:Electromagnetic Phenomena / Q000379:methods*; D005260:Female; D006882:Hydroxyapatites; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D019736:Prostheses and Implants; D011817:Rabbits; D011859:Radiography; D013977:Tibia / Q000000981:diagnostic imaging / Q000254:growth & development / Q000648:ultrastructure; D013997:Time Factors
D002130:Calcium Phosphates; D006882:Hydroxyapatites; D017886:Durapatite