Treatment of nonmetastatic gestational trophoblastic disease with oral methotrexate.
Fifteen patients with nonmetastatic gestational trophoblastic disease were treated solely with methotrexate given orally rather than intramuscularly. Remission, defined as a beta-human chorionic gonadotropin titer of less than 5 mIU/ml for 3 consecutive weeks, was attained in 13 (87%) of the 15 patients. Level of toxicity was acceptable. Patient comfort, convenience, and less time off work and in the physician's office are significant advantages to this efficacious, well-tolerated method of therapy.
Barter
J F
JF
Department of Obstetrics and Gynecology, University of Alabama Medical Center, Birmingham.
Soong
S J
SJ
Hatch
K D
KD
Orr
J W
JW
Partridge
E C
EC
Austin
J M
JM
Shingleton
H M
HM
D000284:Administration, Oral; D000328:Adult; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D012189:Retrospective Studies; D014328:Trophoblastic Neoplasms / Q000188:drug therapy*; D014594:Uterine Neoplasms / Q000188:drug therapy*
D008727:Methotrexate