Growth hormone receptor and serum binding protein: purification, cloning and expression.
A putative growth hormone receptor from rabbit liver and the growth hormone binding protein from rabbit serum have the same amino-terminal amino-acid sequence, indicating that the binding protein corresponds to the extracellular hormone-binding domain of the liver receptor. The complete amino-acid sequences derived from complementary DNA clones encoding the putative human and rabbit growth hormone receptors are not similar to other known proteins, demonstrating a new class of transmembrane receptors.
Leung
D W
DW
Department of Developmental Biology, Genentech, Inc., South San Francisco, California.
Spencer
S A
SA
Cachianes
G
G
Hammonds
R G
RG
Collins
C
C
Henzel
W J
WJ
Barnard
R
R
Waters
M J
MJ
Wood
W I
WI
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics* / Q000302:isolation & purification; D003001:Cloning, Molecular; D004247:DNA / Q000302:isolation & purification / Q000378:metabolism; D004262:DNA Restriction Enzymes; D013006:Growth Hormone / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008969:Molecular Sequence Data; D011817:Rabbits; D011986:Receptors, Somatotropin / Q000235:genetics* / Q000302:isolation & purification; D014158:Transcription, Genetic
D002352:Carrier Proteins; D011986:Receptors, Somatotropin; D013006:Growth Hormone; D004247:DNA; D004262:DNA Restriction Enzymes; C051815:somatotropin-binding protein