title: Polyneuropathy in hypereosinophilic syndrome.
abstract: We investigated two patients with the idiopathic hypereosinophilic syndrome and peripheral neuropathy. Clinical, EMG, and pathological findings were consistent with axonal polyneuropathy. Morphologic changes of the nerve biopsies suggested axonal damage secondary to increased endoneurial pressure from leakage of capillaries. We postulate that endothelial cell damage, followed by nerve edema, is the first step in the pathogenesis of peripheral neuropathy in these patients.
authors.affiliation: Cattedra di Neuropatologia, Verona, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Monaco
authors.forename: B
authors.initials: B
authors.lastname: Lucci
authors.forename: N
authors.initials: N
authors.lastname: Laperchia
authors.forename: F
authors.initials: F
authors.lastname: Tezzon
authors.forename: B
authors.initials: B
authors.lastname: Currò-Dossi
authors.forename: E
authors.initials: E
authors.lastname: Nardelli
authors.forename: C
authors.initials: C
authors.lastname: Giannini
authors.forename: N
authors.initials: N
authors.lastname: Rizzuto
mesh_terms: D001706:Biopsy; D002196:Capillaries / Q000473:pathology; D004487:Edema / Q000209:etiology / Q000503:physiopathology; D004594:Electrophysiology; D004802:Eosinophilia / Q000150:complications* / Q000473:pathology; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010525:Peripheral Nerves / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology / Q000648:ultrastructure; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology