Lack of effect of atrial natriuretic factor on the tone induced in rat portal vein by platelet-activating factor.
The spontaneous myogenic activity of the isolated rat portal vein was inhibited by atrial natriuretic factor or by sodium nitroprusside. These compounds were not effective on the tone induced by PAF-acether or carbachol. 8-Bromo cyclic GMP and dibutyryl cyclic AMP inhibited myogenic activity and reduced the agonist-induced contractions. Only dibutyryl-cyclic AMP significantly inhibited the PAF-acether-induced contractile responses. These results indicate that the tone induced by PAF-acether can be used to discriminate between drugs which selectively increase cyclic nucleotide levels.
Hellegouarch
A
A
Institut Henri Beaufour Research Labs., Le Plessis Robinson, France.
Auguet
M
M
Guillon
J M
JM
Baranes
J
J
Pirotzky
E
E
Braquet
P
P
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D003994:Bucladesine / Q000494:pharmacology; D006152:Cyclic GMP / Q000031:analogs & derivatives / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects*; D009599:Nitroprusside / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000494:pharmacology*; D011169:Portal Vein / Q000502:physiology*; D051381:Rats
D010972:Platelet Activating Factor; C472610:atrial natriuretic peptide, rat; D009599:Nitroprusside; C016276:8-bromocyclic GMP; D003994:Bucladesine; D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP