[Antidiarrheal and anti-inflammatory effects of berberine].
Berberine sulfate (Ber) 40 and 80 mg/kg ig reduced the purging effects of castor oil or Cassia angustifolia leaf in mice, but did not affect the gastrointestinal transport function of Chinese ink in normal mice. Ber 60 mg/kg ig significantly inhibited the increased vascular permeability induced by ip 0.7% acetic acid in mice. Ber 20 and 50 mg/kg sc markedly inhibited the increased vascular permeability induced by histamine 100 micrograms/0.1 ml ic in rats. Ber 4 and 8 mg/kg sc produced obvious inhibition in the xylene-induced swelling of mouse ear. The anti-inflammatory effects were enhanced in a dose-dependent manner. It is suggested that the antidiarrheal effect of Ber is relative to its restriction against exudative inflammation to a certain extent.
Zhang
M F
MF
Shen
Y Q
YQ
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001599:Berberine / Q000494:pharmacology* / Q000627:therapeutic use; D001600:Berberine Alkaloids / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D003967:Diarrhea / Q000188:drug therapy*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001600:Berberine Alkaloids; D001599:Berberine