title: A model for regional blood flow measurements during cardiopulmonary resuscitation in a swine model.
abstract: Recent reports examining regional blood flow during cardiopulmonary resuscitation (CPR) have been criticized for several reasons: (1) cardiac arrest times of 5 min or less are not reflective of the prehospital setting, (2) anesthetic agents may significantly influence autonomic control of regional blood flow, (3) canine cardiac anatomy and coronary blood supply are not reflective of humans and (4) precise validation data for blood flow measurements have not been reported. This study presents a methodology and model for measuring regional blood flow during CPR after a prolonged cardiac arrest. Fifteen swine weighing 15-25.4 kg were instrumented for regional blood flow measurements using tracer microspheres. Regional cerebral and myocardial blood flow were measured during normal sinus rhythm (NSR) and during CPR following a 10-min cardiopulmonary arrest. Regional blood flow (ml/min/100 g) to the cerebral cortices averaged less than 3% of baseline flow (NSR: right cortex = 41.2 +/- 13.8; left cortex = 41.2 +/- 12.2; CPR: right cortex = 1.3 +/- 1.2; left cortex = 1.3 +/- 1.3). Total myocardial blood flow averaged less than 5% of baseline flow (NSR = 211.5 +/- 104.9; CPR = 9.5 +/- 14.9). The flow data demonstrates minimal cardiac and cerebral perfusion with standard CPR following a 10-min arrest. The variability in the pilot data may be used in determining sample sizes for future studies.
authors.affiliation: Division of Emergency Medicine, Ohio State University, College of Medicine, Columbus 43210.
authors.forename: R B
authors.initials: RB
authors.lastname: Taylor
authors.forename: C G
authors.initials: CG
authors.lastname: Brown
authors.forename: T
authors.initials: T
authors.lastname: Bridges
authors.forename: H A
authors.initials: HA
authors.lastname: Werman
authors.forename: J
authors.initials: J
authors.lastname: Ashton
authors.forename: R L
authors.initials: RL
authors.lastname: Hamlin
mesh_terms: D000818:Animals; D002302:Cardiac Output; D002490:Central Nervous System / Q000098:blood supply; D003326:Coronary Circulation; D004195:Disease Models, Animal; D006323:Heart Arrest; D008863:Microspheres; D008955:Models, Cardiovascular; D012039:Regional Blood Flow; D012079:Renal Circulation; D012151:Resuscitation / Q000379:methods*; D013552:Swine; D014693:Ventricular Fibrillation