Involvement of microtubules in Kunjin virus replication. Brief report.
Induction of microtubulin paracrystals (Pc) by Kunjin (KUN) virus occurred after 15 hours post-infection and were often associated with convoluted membranes (cm) and virus particles. Vinblastine sulphate which disrupts microtubulin, had an inhibitory effect on the virus production when added during the viral latent period. When infected samples were extracted with Triton X-100 and analysed by SDS-PAGE, four viral proteins were observed.
Hong
S S
SS
Department of Microbiology, Faculty of Medicine, National University of Singapore.
Ng
M L
ML
D000818:Animals; D005416:Flavivirus / Q000502:physiology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008870:Microtubules / Q000502:physiology*; D008970:Molecular Weight; D014709:Vero Cells; D014747:Vinblastine / Q000494:pharmacology; D014764:Viral Proteins / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects
D014764:Viral Proteins; D014747:Vinblastine