Synthesis and characterization of potential tumor scintigraphic agents.
Potential tumor imaging radiopharmaceutical agents have been prepared by attaching a cisplatin derivative to a ligand capable of forming a stable complex with 99mTc. Three new organometallic compounds, with iminodiacetic acid as the 99mTc chelating group and 2,3-diaminopropionamide as the platinum complexing group, have been prepared and characterized. Preliminary biodistribution studies in tumor bearing mice support the utility of this approach.
Awaluddin
A B
AB
Isotope Division, Prime Minister's Department, Bangi, Malaysia.
Jacobs
J J
JJ
Bourne
D W
DW
Maddalena
D J
DJ
Wilson
J G
JG
Boyd
R E
RE
D000818:Animals; D005260:Female; D006801:Humans; D007202:Indicators and Reagents; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000000981:diagnostic imaging*; D012516:Osteosarcoma / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013329:Structure-Activity Relationship; D013667:Technetium; D014018:Tissue Distribution
D007202:Indicators and Reagents; D013667:Technetium