The effect of chronic lithium administration and withdrawal on locomotor activity and apomorphine-induced locomotor stimulation in rats.
The effect of chronic lithium administration and withdrawal on locomotor activity and apomorphine-induced locomotor stimulation in rats was studied. Chronic lithium administration caused a decrease in locomotor activity, which might be due to a lithium-induced decrease of exploratory behaviour. Chronic lithium administration had no effect on apomorphine-induced locomotor stimulation. However, apomorphine-induced locomotor stimulation was increased two days after the withdrawal of lithium while no difference was found after four days, suggesting a transient increase in postsynaptic dopamine (DA) receptor sensitivity following lithium withdrawal.
Berggren
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Department of Pharmacology, University of Göteborg, Sweden.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002712:Chlorides / Q000009:adverse effects / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D008094:Lithium / Q000009:adverse effects / Q000494:pharmacology*; D018021:Lithium Chloride; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D013997:Time Factors
D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride; D001058:Apomorphine