title: Interstitial pneumonitis following autologous bone marrow transplantation.
abstract: Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7%) and CMV IP (2%) in these marrow autograft recipients were lower than the incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT (P less than or equal to 0.001 for both comparisons).
authors.affiliation: Johns Hopkins Oncology Center, Baltimore, Maryland 21205.
authors.forename: J R
authors.initials: JR
authors.lastname: Wingard
authors.forename: M B
authors.initials: MB
authors.lastname: Sostrin
authors.forename: H M
authors.initials: HM
authors.lastname: Vriesendorp
authors.forename: E D
authors.initials: ED
authors.lastname: Mellits
authors.forename: G W
authors.initials: GW
authors.lastname: Santos
authors.forename: D J
authors.initials: DJ
authors.lastname: Fuller
authors.forename: H G
authors.initials: HG
authors.lastname: Braine
authors.forename: A M
authors.initials: AM
authors.lastname: Yeager
authors.forename: W H
authors.initials: WH
authors.lastname: Burns
authors.forename: R
authors.initials: R
authors.lastname: Saral
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications; D005260:Female; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D008223:Lymphoma / Q000628:therapy*; D008297:Male; D011658:Pulmonary Fibrosis / Q000209:etiology*; D012307:Risk Factors; D014777:Virus Diseases / Q000150:complications