Growth hormone treatment in adults with growth hormone deficiency: effect on muscle fibre size and proportions.
The effect of a 6-month period of substitution therapy with recombinant human growth hormone (rhGH) on muscle fibre size and muscle fibre type proportions has been investigated in a group of 13 adults with growth hormone deficiency. All had a peak growth hormone (GH) response to insulin-induced hypoglycaemia of less than 7 mU/l. There was no statistically significant change in the lesser fibre diameter or fibre proportions of either type 1 or type 2 muscle fibres in the rhGH group, as compared with placebo.
Whitehead
H M
HM
Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Belfast, Northern Ireland, UK.
Gilliland
J S
JS
Allen
I V
IV
Hadden
D R
DR
D000328:Adult; D001823:Body Composition; D005260:Female; D013006:Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects*; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D013006:Growth Hormone