title: Expression of membrane antigens in myotonic dystrophy.
abstract: Muscle biopsies from a series of myotonic dystrophy patients were analysed for expression of the nerve regulated gene products neural cell adhesion molecule (N-CAM) and 5.1H11. All eight biopsy specimens tested strongly expressed N-CAM and 5.1H11 as assessed by indirect immunofluorescence analysis. These results can be compared with those of Renaud et al (Nature, 1986;319:678) that show apamin binding to be a good marker of myotonic dystrophy muscle membranes. We suggest that in myotonic dystrophy a number of nerve regulated membrane markers are precociously expressed by innervated myofibres and that these are likely to be secondary manifestations resulting from an unidentified primary defect.
authors.affiliation: Institute of Neurology, Queen Square, London, UK.
authors.forename: F S
authors.initials: FS
authors.lastname: Walsh
authors.forename: S E
authors.initials: SE
authors.lastname: Moore
authors.forename: J G
authors.initials: JG
authors.lastname: Dickson
mesh_terms: D000328:Adult; D000954:Antigens, Surface / Q000032:analysis*; D001706:Biopsy; D015815:Cell Adhesion Molecules; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis*; D008875:Middle Aged; D009132:Muscles / Q000473:pathology*; D009136:Muscular Dystrophies / Q000473:pathology*; D015221:Potassium Channels; D017981:Receptors, Neurotransmitter / Q000032:analysis*
chemical_list: D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins; D015221:Potassium Channels; D017981:Receptors, Neurotransmitter; C033799:apamin receptor