title: Reconstruction of the ossicular chain with hydroxyapatite prostheses.
abstract: To achieve a lasting result in reconstruction of the ossicular chain, strict material and surgical criteria must be combined. The best biomaterial, apart from bone, is hydroxyapatite, the mineral matrix of living bone tissue. For the reconstruction, the assembly technique is used instead of a columella. Direct contact with the drum membrane is not reliable if a columella is used, and extrusion or lateralization may influence postoperative results. In the case of a missing incus, an assembly prosthesis of dense hydroxyapatite is placed on top of the stapes head and the handle of the malleus, in a pocket between drum membrane and the neck of the malleus. Long postoperative follow-up of 120 patients showed an air-bone gap closure within 20 dB for 83.3% of the patients, no extrusion was observed, and the hearing gain stayed constant. Reconstruction of a tympanic membrane perforation and posterior canal wall was performed in the same stage in sixty patients. In the case of a missing incus and stapes superstructure, an incus/stapes prosthesis of dense hydroxyapatite, as assembly between footplate and handle of the malleus, was used. Long postoperative follow-up of twenty-five patients showed an air-bone gap closure within 20 dB for 68% of the patients. Reconstruction of a tympanic membrane perforation and posterior canal wall was performed in sixteen patients. No extrusion was observed and the hearing gain stayed constant. Hydroxyapatite prostheses have proven to be a good alternative for autologous and homologous ossicles.
authors.affiliation: ENT Department, University Hospital, Leiden, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Grote
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D017886:Durapatite; D004429:Ear Ossicles / Q000601:surgery*; D005260:Female; D006801:Humans; D006882:Hydroxyapatites; D007188:Incus / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009998:Ossicular Prosthesis; D013201:Stapes Surgery
chemical_list: D006882:Hydroxyapatites; D017886:Durapatite