title: Cerebrospinal fluid rhinorrhea occurring in long-term bromocriptine treatment for macroprolactinomas.
abstract: Two patients harboring invasive macroprolactinomas, on treatment with bromocriptine, developed cerebrospinal fluid rhinorrhea 16 and 17 months after the beginning of the medical therapy. Neither patient had previously been submitted to surgery or radiotherapy. The fistulae were surgically corrected. Cerebrospinal fluid leakage is a well-documented complication of pituitary tumors, mainly after surgery and/or radiotherapy, but the reports of its occurrence after primary treatment with bromocriptine are rare. Therefore, the possibility of this complication must be considered, especially in patients with invasive macroprolactinomas.
authors.affiliation: Division of Functional Neurosurgery, Hospital das Clinicas, University of Sao Paulo Medical School, Brazil.
authors.forename: M D
authors.initials: MD
authors.lastname: Bronstein
authors.forename: N R
authors.initials: NR
authors.lastname: Musolino
authors.forename: S
authors.initials: S
authors.lastname: Benabou
authors.forename: R
authors.initials: R
authors.lastname: Marino
mesh_terms: D000328:Adult; D001971:Bromocriptine / Q000009:adverse effects* / Q000627:therapeutic use; D002559:Cerebrospinal Fluid Rhinorrhea / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D015175:Prolactinoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D001971:Bromocriptine