GABA-ergic mechanisms in the central control of cough.
The antitussive activity of gabalinoleamide (Gabalid U CB) was studied in 40 non-anaesthetized cats. The antitussive action of the substance was compared to that of codeine (Codein Spofa). Cough was induced by mechanical stimulation using a chronic tracheal cannula. Single cough parameters were evaluated from changes in the side tracheal pressure. When gabalinoleamide was administered in a dose of 100 mg/kg b.w. intramuscularly all the studied parameters of cough showed a statistically significant decrease, only the intensity of maximum cough effort remained unaffected. Gabalinoleamide administered in the same dose induced a statistically significant decrease of respiratory frequency and breathing amplitude, and prolonged the cycle of breathing by delaying the expiratory phase. Higher doses (200 and 300 mg/kg b.w.) did not have an increased cough suppressing effect. The quality and quantity of cough parameters were similar after codeine and gabalinoleamide.
Nosálová
G
G
Department of Pathophysiology and Pharmacology, Faculty of Medicine, Comenius University, Martin, Czechoslovakia.
Varonos
D
D
Papadopoulou-Daifotis
Z
Z
Visnovský
P
P
Strapková
A
A
D000818:Animals; D000996:Antitussive Agents; D002415:Cats; D003061:Codeine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D011963:Receptors, GABA-A / Q000502:physiology; D012119:Respiration / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D000996:Antitussive Agents; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; C036611:gabalid; D003061:Codeine