Dopamine inhibition of NaKATPase activity in proximal convoluted tubule cells.
Studies of permeabilized rat renal proximal convoluted tubules have demonstrated that NaKATPase activity can be inhibited by locally produced DA. The effect is mediated by a pertussis toxin sensitive inhibitory G-protein. DA inhibition of proximal tubule NaKATPase activity is of physiological importance. During high salt diet renal DA production is increased and the inhibitory effect of DA on NaKATPase is enhanced. DA inhibition of NaKATPase activity will contribute to the natriuresis during high salt diet.
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Department of Pediatrics, Karolinska Institute, St. Göran's Children's Hospital, Stockholm, Sweden.
D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D019204:GTP-Binding Proteins / Q000502:physiology; D007687:Kidney Tubules, Proximal / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D045283:Natriuretic Agents / Q000502:physiology; D037342:Pertussis Toxin; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D010566:Virulence Factors, Bordetella
D045283:Natriuretic Agents; D010566:Virulence Factors, Bordetella; D037342:Pertussis Toxin; D019204:GTP-Binding Proteins; D000254:Sodium-Potassium-Exchanging ATPase; D004298:Dopamine