title: [Pharmacology of central cholinergic synapse].
abstract: Because it intervenes in normal and pathological cerebral ageing, plays a role in late dyskinesias of Parkinson's syndrome and is involved in the memorization processes, central cholinergic neurotransmission deserves to be known with precision. Its physiological approach deals with the anatomical organization of the central cholinergic system and with the mechanisms of synthesis, release and degradation of acetylcholine and its interaction with its receptors. The pharmacological changes (inhibition or stimulation) conceivable at different levels lead to therapeutic applications.
authors.affiliation: Laboratoire de pharmacologie, Université de Rennes.
authors.forename: R
authors.initials: R
authors.lastname: Decombe
authors.forename: D
authors.initials: D
authors.lastname: Bentué-Ferrer
authors.forename: J
authors.initials: J
authors.lastname: Van den Driessche
authors.forename: H
authors.initials: H
authors.lastname: Allain
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D002490:Central Nervous System / Q000502:physiology; D006801:Humans; D010276:Parasympatholytics / Q000494:pharmacology*; D010277:Parasympathomimetics / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D010276:Parasympatholytics; D010277:Parasympathomimetics; D000109:Acetylcholine
vernacular_title: Pharmacologie de la synapse cholinergique centrale.