Calcitonin secretion by human placental tissue.
We have investigated the synthesis in vitro of calcitonin (CT) by human placenta at term. Separate placental tissue samples were incubated in culture medium with various Ca concentrations for 6 h. The CT concentrations in the medium were determined by radio-immunoassay. In addition the effect of DB-cAMP on the synthesis was also studied. We could demonstrate CT secretion in all experiments. The CT concentrations were determined by two different antibodies. Both antibodies registered the CT secretion. Addition of DB-cAMP to the culture medium stimulates the synthesis.
Balabanova
S
S
Department of Forensic Medicine, University of Ulm, F.R.G.
Kruse
B
B
Wolf
A S
AS
D003994:Bucladesine / Q000494:pharmacology; D002116:Calcitonin / Q000378:metabolism*; D002118:Calcium / Q000494:pharmacology; D003470:Culture Media; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
D003470:Culture Media; D003994:Bucladesine; D002116:Calcitonin; D002118:Calcium