Functional atrophy of brown adipose tissue during lactation in mice. Effects of lactation and weaning on mitochondrial GDP binding and uncoupling protein.
The thermogenic activity and capacity of brown adipose tissue were determined in mice during lactation and after weaning. There was a marked fall during lactation in the mitochondrial content of the tissue, and in GDP binding and the specific mitochondrial concentration of uncoupling protein. The lactation-induced functional atrophy of brown adipose tissue was fully reversible after weaning; mitochondrial content and the mitochondrial concentration of uncoupling protein were both restored, although GDP binding was not normalized.
Trayhurn
P
P
Dunn Nutrition Laboratory, Medical Research Council, Cambridge, U.K.
Jennings
G
G
D002001:Adipose Tissue, Brown / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001284:Atrophy / Q000378:metabolism; D002352:Carrier Proteins; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D006153:Guanosine Diphosphate / Q000378:metabolism; D007473:Ion Channels; D007774:Lactation / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins; D009929:Organ Size; D011247:Pregnancy; D011506:Proteins / Q000378:metabolism; D000071256:Uncoupling Protein 1
D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D011506:Proteins; D000071256:Uncoupling Protein 1; D006153:Guanosine Diphosphate; D003576:Electron Transport Complex IV