The effects of dietary fish oil on hepatic high density and low density lipoprotein receptor activities in the rat.
Rats were fed either a standard ration diet or that diet supplemented with 8% by wt of a marine fish oil or safflower oil. After 10 days, plasma triacylglycerols, total cholesterol, high density lipoprotein (HDL) cholesterol, hepatic cholesterol and fatty acid synthesis and hepatic low density lipoprotein (LDL) receptor activity were significantly depressed while HDL receptor activity was significantly increased in rats fed fish oil. Fish oil-induced effects on cholesterol metabolism in the rat therefore include reciprocal changes in the activities of hepatic LDL and HDL receptors.
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CSIRO, Division of Human Nutrition, Adelaide, Australia.
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D000818:Animals; D002352:Carrier Proteins; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D005395:Fish Oils / Q000494:pharmacology*; D007700:Kinetics; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008297:Male; D016601:RNA-Binding Proteins; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D011973:Receptors, LDL / Q000187:drug effects / Q000378:metabolism*; D018110:Receptors, Lipoprotein; D012450:Safflower Oil / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
D002352:Carrier Proteins; D008076:Cholesterol, HDL; D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D008075:Lipoproteins, HDL; D016601:RNA-Binding Proteins; D011956:Receptors, Cell Surface; D011973:Receptors, LDL; D018110:Receptors, Lipoprotein; D014280:Triglycerides; C031616:high density lipoprotein receptors; C075197:high density lipoprotein binding protein; D012450:Safflower Oil; D002784:Cholesterol