Ferret model for acquired subglottic stenosis.
Researchers continue to look for an improved animal model for the study of acquired subglottic stenosis. This report describes a ferret model that reliably produces 40% to 60% stenosis with a method analogous to the pathophysiology of prolonged endotracheal intubation. Unlike some previously developed animal models, this model has a low morbidity and a perioperative mortality of less than 5%. Ferrets are small, hardy animals that are inexpensive and easy to house, handle, and anesthetize. They are readily available from breeders in a uniform size, age, and sex. Their airway is disproportionately large for their body size, making them particularly well suited for the study of acquired subglottic stenosis and subsequent surgical therapy.
Alexander
K J
KJ
Department of Otolaryngology, Columbus Children's Hospital, OH.
Schuller
D E
DE
D000818:Animals; D002335:Carnivora; D004195:Disease Models, Animal; D005289:Ferrets; D007829:Laryngostenosis / Q000209:etiology / Q000473:pathology; D007830:Larynx / Q000473:pathology