title: Circulating opioid peptides during water immersion in normal man.
abstract: 1. This study was designed to evaluate variations in plasma beta-endorphin, methionine-enkephalin, adrenocorticotropic hormone and serum prolactin in healthy volunteers during head-out water immersion. 2. Water immersion induced an increase in methionine-enkephalin plasma levels, which was associated with a significant fall in mean arterial pressure and heart rate. 3. Conversely, a suppression of plasma beta-endorphin, adrenocorticotropic hormone and serum prolactin was detected during water immersion. 4. We suggest that a dopaminergic inhibitory control mechanism may be involved in regulating circulating levels of beta-endorphin, adrenocorticotropic hormone and prolactin in normal subjects undergoing extracellular fluid volume expansion produced by water immersion.
authors.affiliation: Istituto di Semeiotica Medica, University of Parma, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Coruzzi
authors.forename: C
authors.initials: C
authors.lastname: Ravanetti
authors.forename: L
authors.initials: L
authors.lastname: Musiari
authors.forename: A
authors.initials: A
authors.lastname: Biggi
authors.forename: P P
authors.initials: PP
authors.lastname: Vescovi
authors.forename: A
authors.initials: A
authors.lastname: Novarini
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D001794:Blood Pressure; D004723:Endorphins / Q000097:blood*; D004744:Enkephalin, Methionine / Q000097:blood; D006801:Humans; D007101:Immersion / Q000503:physiopathology*; D008297:Male; D011388:Prolactin / Q000097:blood; D001615:beta-Endorphin / Q000097:blood
chemical_list: D004723:Endorphins; D004744:Enkephalin, Methionine; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D011388:Prolactin