title: Effect of sodium depletion on pressor responsiveness in ACTH-induced hypertension in man.
abstract: 1. Pressor responsiveness to angiotensin II (AII) and phenylephrine (PHE) was measured before and after 5 days of ACTH (1 mg i.m. daily) in six normal men maintained on low sodium diet (15 mmol daily). 2. ACTH caused a significant increase in systolic blood pressure of 9 mmHg. 3. There was no change in pressor responsiveness to AII with ACTH. 4. ACTH increased pressor responsiveness to PHE for both systolic and diastolic blood pressure, with a fall in the threshold for response from 0.9 to 0.6 micrograms/kg per min. 5. Increased pressor sensitivity to catecholamines during ACTH administration in man is not sodium-dependent.
authors.affiliation: MRC Blood Pressure Unit, Western Infirmary, Glasgow, Scotland.
authors.forename: J M
authors.initials: JM
authors.lastname: Connell
authors.forename: B M
authors.initials: BM
authors.lastname: Fisher
authors.forename: G
authors.initials: G
authors.lastname: Davidson
authors.forename: R
authors.initials: R
authors.lastname: Fraser
authors.forename: J A
authors.initials: JA
authors.lastname: Whitworth
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000009:adverse effects*; D000328:Adult; D000804:Angiotensin II / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D004039:Diet, Sodium-Restricted; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D007262:Infusions, Intravenous; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology
chemical_list: D000804:Angiotensin II; D010656:Phenylephrine; D000324:Adrenocorticotropic Hormone