Enhanced formation of cyclic AMP after cold acclimation in the rat.
Plasma cAMP response to glucagon was enhanced after cold acclimation. Cold-acclimated rats also showed an enhanced production of hepatic cAMP in response to glucagon. In both brown and white fat tissues, cAMP contents increased after cold acclimation. Enhancement of cAMP formation in the liver and fat tissues may partly contribute to an enhanced nonshivering thermogenesis during cold acclimation.
Habara
Y
Y
Department of Physiology, Asahikawa Medical College, Japan.
Kuroshima
A
A
D000064:Acclimatization; D002001:Adipose Tissue, Brown / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003080:Cold Temperature; D000242:Cyclic AMP / Q000096:biosynthesis*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005934:Glucagon / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D005934:Glucagon; D000242:Cyclic AMP; D009638:Norepinephrine