[Preliminary results of a randomized trial comparing the efficacy of standard heparin with that of fragmine, a low molecular weight heparin, in the prevention of postoperative thrombosis in cancer surgery].
Low molecular weight heparins have stimulated much interest because of their supposedly more selective action on Xa factor. A randomized study in 50 patients compared efficacy of low doses of a standard heparin, calciparin (5,000 IU/8 h) with that of a low molecular weight heparin, fragmine (Kabi 2165) (5,000 anti-Xa U/24 h), in the prophylaxis of postoperative thrombosis after oncologic surgery. Three of 25 patients receiving calciparin developed pulmonary embolism, as against one of 25 treated with fragmine who developed a periphlebitis. Hemorrhagic complications were comparable in the two groups. Anti-Xa activity was significantly higher in the fragmine group, whereas platelet counts, cephalin times with activator and anti-IIa activity were similar. These findings indicate equal efficacy of fragmine and calciparin in the prophylaxis of post-oncology surgery venous thrombosis.
Grunebaum
L
L
Service d'Hémostase et de Thrombose, Centre Régional de Transfusion Sanguine, Strasbourg.
Fricker
J P
JP
Wiesel
M L
ML
Vergnes
Y
Y
Kapps
J
J
Cazenave
J P
JP
D000328:Adult; D001780:Blood Coagulation Tests; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005170:Factor X / Q000032:analysis / Q000037:antagonists & inhibitors; D006493:Heparin / Q000627:therapeutic use*; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control*; D011897:Random Allocation; D013927:Thrombosis / Q000517:prevention & control*
D006495:Heparin, Low-Molecular-Weight; D005170:Factor X; D006493:Heparin
Résultats préliminaires d'un essai randomisé comparant l'efficacité d'une héparine standard à celle de la fragmine, une héparine de bas poids moléculaire, dans la prophylaxie des thromboses post-opératoires en chirurgie oncologique.