title: [The Drosophila mobile element jockey is a LINE element and contains coding sequences homologous to retroviral proteins].
abstract: A detailed investigation of Drosophila melanogaster mobile dispersed repetitive element jockey is performed. Its structural features resemble those of LINE elements. Sequencing of the complete jockey 5020 bp in length revealed two long open reading frames ORF1 and ORF2 overlapping with a frameshift-1. Judging by amino acid homologies, ORF1 encodes a nucleic acid binding protein, characteristic of replication competent retroviruses; the 3' part of ORF2 encodes an RNA-dependent DNA polymerase which has an amino acid sequence, similar to recently published sequences of LINE elements of Drosophila, Trypanosoma and mammals. This fact demonstrates their evolutionary relationship. Sequencing of several deleted copies of jockey revealed the absence of the major part of ORF2, though the rest of the element, including the ends, is highly conservative.
authors.forename: A F
authors.initials: AF
authors.lastname: Priĭmiagi
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Mizrokhi
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Il'in
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004251:DNA Transposable Elements; D004279:DNA, Viral / Q000235:genetics; D004331:Drosophila melanogaster; D005815:Genetic Code; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid; D012191:Retroviridae Proteins / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004251:DNA Transposable Elements; D004279:DNA, Viral; D012191:Retroviridae Proteins; D004247:DNA
vernacular_title: Mobil'nyĭ élement drozofily--zhokeĭ iavliaetsia LINE-élementom i soderzhit kodiruiushchie posledovatel'nosti, gomologichnye nekotorym belkam retrovirusov.