Defective phosphoinositide metabolism in primary hypertension.
An increase in free cytosolic calcium content has been reported in essential hypertension. Since within the membrane, the phosphoinositides participate in the control of cell calcium homeostasis, we investigated whether impaired phosphoinositide metabolism could account for the calcium handling abnormality observed in hypertensives. In erythrocyte membranes of hypertensives the activity of kinases involved in polyphosphoinositide formation appears to be impaired and could be related to the alteration in calcium handling binding capacity and ATP-dependent calcium transport. In platelets of hypertensives, the hyperactivity of phospholipase C (observed even in the absence of calcium in the external medium) is likely to be responsible for the hypersensitivity of cells to various agonists. These observations are consistent with the hypothesis that in cells from hypertensives, a membrane defect linked to phosphoinositide metabolism is involved in the overall calcium handling defect.
Remmal
A
A
INSERM U7, Department of Pharmacology, Hôpital Necker, Paris, France.
Koutouzov
S
S
Girard
A
A
Meyer
P
P
Marche
P
P
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000201:enzymology / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000097:blood / Q000378:metabolism*; D010738:Type C Phospholipases / Q000097:blood / Q000502:physiology
D010716:Phosphatidylinositols; D010738:Type C Phospholipases