Midazolam-thiopental anesthetic interaction in patients.
The effect of thiopental on the induction dose-response curve for midazolam was studied in nonpremedicated ASA physical status I and II patients. As an endpoint of anesthesia, ability to open eyes on command was used. Dose-response curves for thiopental, midazolam, and their combination were determined with a probit procedure and compared with an isobolographic analysis. Interaction between midazolam and thiopental was found to be synergistic (supraadditive). The degree of midazolam-thiopental anesthetic synergism in surgical patients was close to that reported previously in rats with loss of the righting reflex as an index of anesthesia.
Tverskoy
M
M
Department of Anesthesiology, Rebecca Sieff Government Hospital, Safed, Israel.
Fleyshman
G
G
Bradley
E L
EL
Kissin
I
I
D000328:Adult; D000758:Anesthesia; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008874:Midazolam / Q000494:pharmacology*; D008875:Middle Aged; D011963:Receptors, GABA-A / Q000187:drug effects; D013874:Thiopental / Q000494:pharmacology*
D011963:Receptors, GABA-A; D013874:Thiopental; D008874:Midazolam