title: 99mTc-aminohexylidendiphosphonate and 99mTc-pyrophosphate in the scintigraphic diagnosis of experimental cardiomyopathy in dogs.
abstract: Experimental cardiomyopathy was provoked in 24 dogs with high intravenous doses of adrenaline and theophylline. These lesions were studied by means of the new agent 99mTc-AHDP and 99mTc-PYP in comparison. Cardiomyopathy could be imaged as early as 4 h after the onset of involvement but not later than 7 days. A maximum accumulation occurred in lesions 24 h old. 99mTc uptake in the myocardium was graded scintigraphically. 99mTc-AHDP was accumulated in the altered myocardium to a greater extent than 99mTc-PYP. Scintigraphic findings were in good agreement with plasma levels of creatine-kinase. A comparison with histology demonstrated that the maximum accumulation of radiopharmaceuticals occurred at the time when the development of myocardium involvement reached the stage of myocytolysis.
authors.affiliation: Dept. of Normal and Pathological Physiology, Charles University, Medical Faculty, Hradec Králové, CSSR.
authors.forename: F
authors.initials: F
authors.lastname: Duska
authors.forename: L
authors.initials: L
authors.lastname: Hadas
authors.forename: J
authors.initials: J
authors.lastname: Vizda
authors.forename: P
authors.initials: P
authors.lastname: Kafka
authors.forename: Y
authors.initials: Y
authors.lastname: Mazurová
authors.forename: V
authors.initials: V
authors.lastname: Palicka
authors.forename: V
authors.initials: V
authors.lastname: Grossman
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000000981:diagnostic imaging*; D011756:Diphosphates; D004164:Diphosphonates; D004285:Dogs; D004837:Epinephrine; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate; D013806:Theophylline
chemical_list: D011756:Diphosphates; D004164:Diphosphonates; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; C054782:technetium Tc 99m aminohexylidendiphosphonate; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium; D013806:Theophylline; D004837:Epinephrine