title: Molecular cloning of the antagonist-binding subunit of the glycine receptor.
abstract: The postsynaptic receptor for the inhibitory neurotransmitter glycine is a heterooligomeric membrane protein which, after affinity purification on an antagonist column, contains three polypeptides of 48K, 58K and 93K. Sequencing of cDNA clones of the antagonist-binding 48K subunit revealed a structural organization similar to and significant amino acid homology with nicotinic acetylcholine receptor proteins. Our data suggest the existence of a set of related genes encoding transmembrane channel-forming neurotransmitter receptor polypeptides of excitable membranes.
authors.affiliation: ZMBH, Universität Heidelberg, FRG.
authors.forename: G
authors.initials: G
authors.lastname: Grenningloh
authors.forename: A
authors.initials: A
authors.lastname: Rienitz
authors.forename: B
authors.initials: B
authors.lastname: Schmitt
authors.forename: C
authors.initials: C
authors.lastname: Methfessel
authors.forename: M
authors.initials: M
authors.lastname: Zensen
authors.forename: K
authors.initials: K
authors.lastname: Beyreuther
authors.forename: E D
authors.initials: ED
authors.lastname: Gundelfinger
authors.forename: H
authors.initials: H
authors.lastname: Betz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004331:Drosophila melanogaster; D005796:Genes; D051381:Rats; D018009:Receptors, Glycine; D017981:Receptors, Neurotransmitter / Q000235:genetics* / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D013331:Strychnine / Q000378:metabolism; D014981:Xenopus
chemical_list: D018009:Receptors, Glycine; D017981:Receptors, Neurotransmitter; D011978:Receptors, Nicotinic; D004247:DNA; D013331:Strychnine