title: [Interleukin-1 and fibrinolysis. In vivo studies].
abstract: Distinct decrease in fibrinolytic activity of both whole blood plasma and its euglobulin fraction, occurring due to liberation of an inhibitor of plasminogen activator into circulation, was observed within 2-4 hrs after a single intravenous administration of rabbit interleukin-I into rats at a dose of 50 micrograms/kg, while the activator activity was increased in kidney heart, spleen and lung tissues. The similar data were obtained if the dose was either increased up to 150 micrograms/kg or decreased down to 5 micrograms/kg and 0.5 micrograms/kg, but the effect observed proved to be dose-dependent. Three injections of interleukin-I caused more pronounced increase in concentration of fibrinogen and antiplasmins as compared with controls.
authors.forename: L V
authors.initials: LV
authors.lastname: Liutova
authors.forename: G V
authors.initials: GV
authors.lastname: Andreenko
authors.forename: M A
authors.initials: MA
authors.lastname: Karabasova
authors.forename: E G
authors.initials: EG
authors.lastname: Rybakina
authors.forename: I A
authors.initials: IA
authors.lastname: Kozinets
authors.forename: I P
authors.initials: IP
authors.lastname: Ashmarin
mesh_terms: D000818:Animals; D005342:Fibrinolysis / Q000187:drug effects*; D007375:Interleukin-1 / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D015849:Plasminogen Inactivators / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000378:metabolism
chemical_list: D007375:Interleukin-1; D015849:Plasminogen Inactivators
vernacular_title: Interleĭkin-1 i fibrinoliz. Issledovaniia v usloviiakh in vivo.