Suppression of feline bone marrow fibroblast colony-forming units by feline leukemia virus.
Bone marrow fibroblast colony-forming units (CFU-F) were evaluated in cats experimentally infected with feline leukemia virus (FeLV). Cats that developed persistent viral infection and anemia (progressor cats) had a progressive decrease in the number of CFU-F at 2, 4, 6, 8, and 10 weeks after inoculation with FeLV. This suppression of CFU-F number in progressor cats ranged from 16 to 44% of the preinoculation CFU-F value. Cats that did not develop persistent viral infection or anemia (regressor cats) had decreased numbers of CFU-F (24% of the preinoculation CFU-F value) at 2 weeks after inoculation, but normal CFU-F numbers at 4, 6, 8, and 10 weeks after inoculation. In vitro incubation of bone marrow mononuclear cells from healthy cats with the 15,000-dalton envelope protein of FeLV resulted in decreased number of CFU-F (21% of that of untreated cultures). The number of CFU-F from bone marrow mononuclear cells incubated with the 27,000-dalton core protein of FeLV was similar to that from untreated cultures.
Wellman
M L
ML
Department of Veterinary Pathobiology, College of Veterinary Medicine, Ohio State University, Columbus 43210.
Kociba
G J
GJ
Mathes
L E
LE
Olsen
R G
RG
D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D003114:Colony-Forming Units Assay; D005347:Fibroblasts / Q000473:pathology; D007938:Leukemia / Q000473:pathology / Q000662:veterinary*; D005256:Leukemia Virus, Feline / Q000502:physiology; D007963:Leukocytes, Mononuclear / Q000473:pathology; D012191:Retroviridae Proteins / Q000502:physiology; D015682:Retroviridae Proteins, Oncogenic; D013047:Specific Pathogen-Free Organisms; D013234:Stem Cells / Q000473:pathology*; D014759:Viral Envelope Proteins / Q000502:physiology
D012191:Retroviridae Proteins; D015682:Retroviridae Proteins, Oncogenic; D014759:Viral Envelope Proteins; C051525:feline leukemia virus protein p15E