[Nyctohemeral variations of cyclosporine administered orally in renal transplant patients].
The circadian intraindividual variations of cyclosporin blood concentrations were studied in nine renal transplant patients at steady state. The cyclosporin was administrated orally twice a day (9 a.m. and 21 p.m.). Blood concentrations were analysed by H.P.L.C. AUC = area under the drug concentration versus time curve, Cmax = maximum blood concentration, Cmin = minimum blood concentration, Tmax = Time to maximum concentration. Statistical analysis (t, Wilcoxon) shows: AUC, Cmax and Tmax are not significantly modified, Cmin (21) less than Cmin (9) (p less than 0.02). This phenomenon seems to be rather a cyclosporin metabolism variation than an absorption alteration.
Ramon
M
M
Morel
D
D
Penouil
F
F
Grellet
J
J
Potaux
L
L
Saux
M C
MC
Brachet-Liermain
A
A
D000284:Administration, Oral; D000328:Adult; D002940:Circadian Rhythm; D003524:Cyclosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged
D003524:Cyclosporins
Variations nycthémérales de la ciclosporine administrée par voie orale à des transplantés rénaux.