[The effect of blood serum on synthesis of lipids in rat thymocytes].
The increase in the incorporation of [2-14C]sodium acetate into cholesterol, free fatty acids and rat thymocyte phospholipids during incubation of rat cells in the absence of blood serum was demonstrated. The label incorporation into the thymocytes was found to be activated in an insignificant degree. Rat blood sera obtained 1 hour after gamma-irradiation of animals with doses of 4 and 10 Gr contained the same concentrations of cholesterol and its esters as the intact rat sera. Irradiation of animals did not affect the ability of the sera to inhibit lipid synthesis in thymocytes or the levels of total phospholipids, cholesterol and its esters. Incubation of cells with the blood sera from irradiated rats led to an increase in the cholesterol/cholesterol ester ratio in the incubation mixture.
Kulagina
T P
TP
Kolomiĭtseva
I K
IK
D000818:Animals; D001769:Blood; D002784:Cholesterol / Q000097:blood; D002788:Cholesterol Esters / Q000097:blood; D008055:Lipids / Q000096:biosynthesis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism* / Q000528:radiation effects
D002788:Cholesterol Esters; D008055:Lipids; D002784:Cholesterol
Vliianie syvorotki na sintez lipidov v timotsitakh krys.