title: Rate of bactericidal activity for Branhamella catarrhalis of a new macrolide, CP-62,993, compared with that of amoxicillin-clavulanic acid.
abstract: The rate of bactericidal activity of a new macrolide, CP-62,993, was compared with that of the combination of amoxicillin and clavulanic acid (in the proportion of 4 to 1) on strains of Branhamella catarrhalis beta-lactamase producers. The antibacterial activity of CP-62,993 was bacterostatic at 0.01 micrograms/ml. After a 6-hour period of bacteriostasis a bactericidal activity (3 log10 CFU/ml) was observed for all concentrations from 0.1 to 10 micrograms/ml after 24 h. The bactericidal rate of amoxicillin-clavulanic acid combination was more rapid during the first 6 h at 1 and 10 micrograms/ml. However, the concentration required to kill 99.9% of bacteria within 24 h was 1 microgram/ml. In conclusion, CP-62,993 was a bactericidal antibiotic for B. catarrhalis at a lower concentration. This in vitro study suggests that this macrolide may be of great interest in infections due to the B. catarrhalis beta-lactamase producer.
authors.affiliation: Department of Microbiology, Brugmann University Hospital, Brussels, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Yourassowsky
authors.forename: M P
authors.initials: MP
authors.lastname: van der Linden
authors.forename: M J
authors.initials: MJ
authors.lastname: Lismont
authors.forename: F
authors.initials: F
authors.lastname: Crokaert
authors.forename: Y
authors.initials: Y
authors.lastname: Glupczynski
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology*; D019980:Amoxicillin-Potassium Clavulanate Combination; D017963:Azithromycin; D002969:Clavulanic Acids / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D001936:Moraxella catarrhalis / Q000187:drug effects*; D013997:Time Factors
chemical_list: D002969:Clavulanic Acids; D004338:Drug Combinations; D004917:Erythromycin; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin; D017963:Azithromycin