Retinoic binding in melanomas of the eye and in normal choroid.
Binding proteins for retinoic acid (cellular retinoid acid binding protein, CRABP), and for vitamin A (cellular retinol binding protein, CRBP) have been demonstrated in various cell types; these binding proteins display the characteristics of receptors. In the present study CRABP and CRBP levels were measured in 9 melanomas of the choroid. CRABP was detected in 2 of the melanomas, whereas CRBP was measurable in 1 melanoma. In comparison samples of normal choroid contained CRABP and CRBP in all cases investigated.
Daxecker
F
F
Department of Ophthalmology, University of Innsbruck, Austria.
Marth
C
C
Daxenbichler
G
G
D002352:Carrier Proteins / Q000032:analysis*; D002829:Choroid / Q000032:analysis*; D005134:Eye Neoplasms / Q000032:analysis*; D006801:Humans; D008545:Melanoma / Q000032:analysis*; D018168:Receptors, Retinoic Acid; D012177:Retinol-Binding Proteins / Q000032:analysis*; D054840:Retinol-Binding Proteins, Cellular
D002352:Carrier Proteins; D018168:Receptors, Retinoic Acid; D012177:Retinol-Binding Proteins; D054840:Retinol-Binding Proteins, Cellular