title: Acetylcholine receptor density and binding in murine dystrophy.
abstract: The concentration and binding characteristics of acetylcholine receptors (AChR) in sarcolemmal fractions from normal and dystrophic mice have been measured. Unlike the results following denervation, AChR concentration (per g wet weight) is unchanged and AChR affinity for two different alpha-neurotoxins is also unchanged. In contrast sarcolemmal ATPase is significantly reduced in dystrophic tissues. These data reaffirm that denervation is a poor model of dystrophy.
authors.affiliation: Department of Biology, York University, Downsview, Ontario, Canada.
authors.forename: T P
authors.initials: TP
authors.lastname: Kruck
authors.forename: D M
authors.initials: DM
authors.lastname: Logan
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D002038:Bungarotoxins / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008817:Mice, Mutant Strains; D009121:Muscle Denervation; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D009498:Neurotoxins / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000378:metabolism*; D012508:Sarcolemma / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D002038:Bungarotoxins; D009498:Neurotoxins; D011950:Receptors, Cholinergic; D000254:Sodium-Potassium-Exchanging ATPase