[Continuous effect of azone pretreatment on permeability of antivirotic Ara-ADA through hairless mouse skin].
In the present studies, two chamber cells were used to measure antivirotic Ara-ADA permeability through 4-6 weeks-old hairless mouse abdominal skin pretreated with Azone for 24 hours. Continuous effect of enhanced percutaneous penetration with Azone pretreatment was studied. After skin was pretreated with Azone, permeability coefficients were determined immediately and after 4, 5, 6, 7, 8 days. The results showed that increase of Permeability coefficient reached 44 times after Azone pretreatment. The enhancement can maintain for at least 8 days and lags of diffusion time were distinctly shortened.
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D000279:Administration, Cutaneous; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001381:Azepines / Q000494:pharmacology*; D051379:Mice; D008812:Mice, Hairless; D010539:Permeability; D012869:Skin Absorption / Q000187:drug effects*; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D000998:Antiviral Agents; D001381:Azepines; C035229:laurocapram; C034898:vidarabine 2',3'-diacetate; D014740:Vidarabine