Estimates of normal binding of a human recombinant alpha interferon to peripheral blood mononuclear cells from a study matching healthy subjects to subjects with insulin dependent diabetes.
This study compares the binding of a human recombinant alpha-interferon to peripheral blood mononuclear cells (PBMC) from patients with insulin dependent diabetes (IDDM) mellitus and control subjects. Diurnal and longer term of variation, feeding, fasting and haemoglobin glycosylation were examinated for their influence on interferon binding to PBMC. No gross differences in binding were demonstrated, in particular no effect of glucose levels was seen on the binding of interferon alpha-2 to PBMC.
Boucher
B J
BJ
Medical Unit, London Hospital Medical College, United Kingdom.
Toms
G C
GC
Temple
R C
RC
Baker
P
P
Mogensen
K E
KE
D001786:Blood Glucose; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D011869:Radioligand Assay; D011994:Recombinant Proteins; D013997:Time Factors
D001786:Blood Glucose; D007370:Interferon Type I; D011994:Recombinant Proteins