Effect of PK 11195, an antagonist of benzodiazepine receptors, on platelet aggregation in a model of anxiety in the rat.
1. Anxiety induced by forced swimming increases maximal intensity (h) of platelet aggregation (PAG) and time to reach it (t). 2. PK 11195 pretreatment (12.5 and 25 mg/kg) reverses anxiety-induced PAG changes. At 6.25 mg/kg it inhibits PAG. 3. Changes induced by anxiety on PAG may be mediated by peripheral-benzodiazepine receptors.
Serrano
J S
JS
Departamento de Farmacologia y Terapéutica, Facultad de Medicina, Sevilla, Spain.
Hevia
A
A
Fernández-Alonso
A
A
Castillo
J R
JR
D000818:Animals; D001007:Anxiety / Q000097:blood*; D005260:Female; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000378:metabolism*
D007546:Isoquinolines; D011963:Receptors, GABA-A; C037850:PK 11195