Itraconazole in the treatment of acute vaginal candidiasis.
In a multicentre open prospective study itraconazole was evaluated in the treatment of acute vaginal candidiasis. Two dosage regimens were tested--200 mg twice a day for 1 day and 200 mg twice a day for 2 days. There were no statistically significant differences between these dosages, and cure rates at 7 and 28 days after treatment were 83% and 75% respectively. These are marginally lower than those produced by longer courses of oral ketoconazole (Nizoral; Janssen) and vaginal econazole nitrate but the advantages are better patient compliance and greater cost-effectiveness.
Bloch
B
B
Department of Obstetrics and Gynaecology, University of Cape Town.
Barnard
P G
PG
Burger
G D
GD
Meyer
J S
JS
Parkes
J R
JR
Smythe
E
E
D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D011446:Prospective Studies; D011897:Random Allocation
D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole