title: Technetium-99m dimercaptosuccinic acid uptake in long-term catheterized kidney. Comparison with renal function.
abstract: We studied 23 long-term catheterized kidneys in 14 patients. The uptake of 99mtechnetium dimercaptosuccinic acid (99mTc-DMSA) was measured at one- and two-hour intervals after injection, and the uptake was corrected for variations in renal depth. These values were compared with inulin, creatinine, and para-amino hippurate (PAH) clearances which were measured in each kidney by collecting urine through long-term catheterization. Correlation coefficient was obtained between PAH clearance corrected for the body surface area and the two-hour uptake of 99mTc-DMSA. The correlation coefficients between the two-hour uptake of 99mTc-DMSA and the clearance values are not significantly different from those between the one-hour uptake and the clearance values. Corrections of the uptake for variations in renal depth did not improve the correlation coefficients. The results show that 99mTc-DMSA is an excellent method to estimate the renal plasma flow and the one-hour uptake without correction for renal depth is clinically sufficient to evaluate the split renal function.
authors.affiliation: Department of Urology, University of Tokyo, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Higashihara
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
authors.forename: H
authors.initials: H
authors.lastname: Kishi
authors.forename: T
authors.initials: T
authors.lastname: Niijima
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
authors.forename: J
authors.initials: J
authors.lastname: Nishikawa
authors.forename: M
authors.initials: M
authors.lastname: Iio
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009403:Nephrostomy, Percutaneous; D009942:Organometallic Compounds; D011877:Radionuclide Imaging; D012079:Renal Circulation; D004113:Succimer; D013438:Sulfhydryl Compounds; D013667:Technetium; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013997:Time Factors; D014547:Urinary Diversion
chemical_list: D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013667:Technetium; D004113:Succimer