[Clinical studies on cefoperazone and polymyxin B for the treatment of infections in patients with hematological malignancies].
Cefoperazone (CPZ) was used for the treatment of 20 febrile episodes in 18 patients with hematological malignancies and polymyxin B (PL) was applied to the antimicrobial decontamination of the digestive tract in 9 patients with acute leukemia during remission induction therapy. The clinical evaluation of effectiveness was as follows: Excellent in 9 patients (45%), good in 6 patients (30%) and poor in 5 patients (25%). In neutropenic patients the overall efficacy rate was 70%. Side effects were recognized in 3 patients. Allergic reactions such as eruption and eosinophilia were seen and transient liver dysfunction was recognized. This study indicates that CPZ is effective for the treatment of infections in patients with hematological malignancies.
Hara
M
M
Department of Medicine, Ehime Prefectural Central Hospital.
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy*; D002438:Cefoperazone / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011112:Polymyxin B / Q000008:administration & dosage* / Q000009:adverse effects; D011113:Polymyxins / Q000008:administration & dosage*
D011113:Polymyxins; D002438:Cefoperazone; D011112:Polymyxin B