[Intensification of the diabetogenic effect of alloxan by protamine sulfate].
Administration of protamine sulfate into circulation was shown to increase the diabetogenic effect of alloxan. Protamine sulfate bound endogenous heparin, as a result of which the diabetogenic factor caused more severe forms of experimental diabetes. At the same time, the diabetogenic factor exhibited distinctly higher activity during the heparin deficiency developed.
Kudriashov
B A
BA
Ul'ianov
A M
AM
Tarasov
Iu A
IuA
D000496:Alloxan / Q000633:toxicity*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000378:metabolism; D006494:Heparin Antagonists; D008297:Male; D011479:Protamines / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical
D006494:Heparin Antagonists; D011479:Protamines; D000496:Alloxan
Usilenie protamina sul'fatom diabetogennogo deĭstviia alloksana.