Effect of suppression of prolactin on gonadal function in immature male hamsters.
The effect of chronic suppression of serum prolactin levels in immature male hamsters has been studied by injecting 15 micrograms of bromoergocryptine (EBC) for 20 days. A statistically significant decrease in serum testosterone, responsiveness to injected human chronic gonadotropin as judged by increase in serum testosterone and binding of 125I hCG in EBC treated animals was noticed. However there was no statistically significant decrease in testicular weight and serum prolactin was decreased only by 31% compared to the controls.
Rao
A J
AJ
Department of Biochemistry, Indian Institute of Science, Bangalore.
Kotagi
S G
SG
D000818:Animals; D000833:Animals, Suckling; D001971:Bromocriptine / Q000494:pharmacology*; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D009929:Organ Size / Q000187:drug effects; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D011388:Prolactin / Q000097:blood / Q000502:physiology*; D012636:Secretory Rate / Q000187:drug effects; D012669:Seminal Vesicles / Q000187:drug effects; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D001971:Bromocriptine; D013739:Testosterone; D011388:Prolactin