Myelofibrosis in cats with myelodysplastic syndrome and acute myelogenous leukemia.
Bone marrow sections from 44 cats with myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML) were graded for reticulin content using light microscopic methods. Twenty-seven (61%) of the cats had slight to marked reticulin myelofibrosis. The association of myelofibrosis with possible pathogenetic factors, including megakaryocyte count, intramedullary lymphoid follicles, hemosiderin content, and FeLV antigenemia, was examined. No evidence was found that indicated a causal relationship between myelofibrosis and any of these factors.
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Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001853:Bone Marrow / Q000032:analysis / Q000473:pathology; D002371:Cat Diseases / Q000209:etiology / Q000473:pathology*; D002415:Cats; D006485:Hemosiderin / Q000032:analysis; D005256:Leukemia Virus, Feline / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008533:Megakaryocytes; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D055728:Primary Myelofibrosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D012155:Reticulin / Q000032:analysis
D000956:Antigens, Viral; D012155:Reticulin; D006485:Hemosiderin