title: Effect of histamine on human vas deferens in vitro.
abstract: Histamine, 2-methylhistamine and 4-methylhistamine produced concentration-related contractions in some isolated human vas deferens preparations. The contractions produced by histamine and its analogues were reversibly and competitively antagonised by the H1-receptor blocker, mepyramine, but not the H2-receptor blockers, burimamide and cimetidine. Phentolamine, atropine and guanethidine did not affect the excitatory action of histamine. Histamine and 4-methylhistamine did not show any inhibitory effect on KCl-induced tone. The results showed that histamine receptors were present in the human vas deferens and the histamine receptors mediating the excitatory response were likely to be H1-receptors.
authors.affiliation: Department of Obstetrics and Gynaecology, National University of Singapore.
authors.forename: L C
authors.initials: LC
authors.lastname: Lau
authors.forename: P G
authors.initials: PG
authors.lastname: Adaikan
authors.forename: S S
authors.initials: SS
authors.lastname: Ratnam
mesh_terms: D002049:Burimamide / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008761:Methylhistamines / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D011738:Pyrilamine / Q000494:pharmacology; D014649:Vas Deferens / Q000187:drug effects*
chemical_list: D008761:Methylhistamines; C025566:4-methylhistamine; D002927:Cimetidine; D006632:Histamine; C026259:2-methylhistamine; D011738:Pyrilamine; D002049:Burimamide