v-jun is a transcriptional activator, but not in all cell-lines.
The recently isolated v-jun oncogene encodes a protein with sequence homology to the transcription factor AP1, as well as a similar DNA binding specificity. We show, by expressing v-jun in F9 embryocarcinoma cells, that v-jun is also a transcriptional activator. However, v-jun expression does not activate transcription in several other cell-lines, suggesting that cell-specific factors are required for v-jun activity.
Imler
J L
JL
Laboratoire de Génétique Moléculaire des Eucaryotes, CNRS, Strasbourg, France.
Ugarte
E
E
Wasylyk
C
C
Wasylyk
B
B
D000818:Animals; D002460:Cell Line; D005347:Fibroblasts / Q000378:metabolism; D005786:Gene Expression Regulation; D051379:Mice; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D011120:Polyomavirus / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic; D014162:Transfection
D011518:Proto-Oncogene Proteins; D014157:Transcription Factors