Rise in plasma beta-endorphin, ACTH, and cortisol in cancer patients undergoing whole body hyperthermia.
It has been previously reported that sauna-induced fevers (approximately 39 degrees C) result in rises of beta-endorphins in normal volunteers. This report describes changes in plasma beta-endorphins in cancer patients undergoing whole body hyperthermia (40.5 degrees C to 41.8 degrees C). Results presented show that there is a linear relationship between thermal stress, defined in terms of core temperature and/or duration of hyperthermia, and the quantitative rise in plasma beta-endorphin levels. Data relating to changes in ACTH and cortisol levels are in a single temperature range (41.5 degrees C--41.8 degrees C) are also reported.
Robins
H I
HI
Department of Human Oncology, University of Wisconsin Clinical Cancer Center, Madison.
Kalin
N H
NH
Shelton
S E
SE
Martin
P A
PA
Shecterle
L M
LM
Barksdale
C M
CM
Neville
A J
AJ
Marshall
J
J
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D003110:Colonic Neoplasms / Q000097:blood / Q000628:therapy; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D006979:Hyperthermia, Induced; D008297:Male; D008545:Melanoma / Q000097:blood / Q000628:therapy; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000628:therapy*; D010190:Pancreatic Neoplasms / Q000097:blood / Q000628:therapy; D012509:Sarcoma / Q000097:blood / Q000628:therapy; D001615:beta-Endorphin / Q000097:blood*
D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone