Neurotransmitter receptor interactions with G-proteins: a critical link in receptor response mechanisms.
The interaction of membrane bound receptors with guanine nucleotide binding regulatory proteins is necessary for the transduction of many extracellular signals across the cell membrane. Age-related impairments of this interaction illustrate that the efficiency of receptor effector coupling is complex, and is an additional factor for consideration in the future study of receptor mediated functions.
Severson
J A
JA
Amersham Corporation, Arlington Heights, IL 60005.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000375:Aging / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D001696:Biomechanical Phenomena; D019204:GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000201:enzymology / Q000502:physiology; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011954:Receptors, Dopamine / Q000378:metabolism; D017448:Receptors, Dopamine D2; D017981:Receptors, Neurotransmitter / Q000378:metabolism / Q000502:physiology*
D011943:Receptors, Adrenergic, beta; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D017981:Receptors, Neurotransmitter; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases