Effects of CDP-choline on phospholipase A2 and cholinephosphotransferase activities following a cryogenic brain injury in the rabbit.
Within the tissue surrounding the necrotic lesion, following a cryogenic injury of the brain, there is a definite activation of phospholipase A2 (at 2 and 4 hr post lesion) that accounts, at least in part, for the phospholipid breakdown. There is also an activation of cholinephosphotransferase (at 2 hr post lesion) that may correspond to an early process of phospholipid resynthesis. Oral CDP-choline in this model is able to completely inhibit the activation of phospholipase A2, but has no detectable effect on cholinephosphotransferase activity. The beneficial effect of CDP-choline might be explained by a prevention of destruction rather than by an enhancement of reconstruction of phospholipids.
Arrigoni
E
E
Laboratoire de Neurochirurgie Expérimentale et Neurobiologie, Université de Bordeaux II, C.N.R.S., France.
Averet
N
N
Cohadon
F
F
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002118:Calcium / Q000378:metabolism; D002794:Choline / Q000031:analogs & derivatives*; D003080:Cold Temperature / Q000009:adverse effects*; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology*; D002798:Diacylglycerol Cholinephosphotransferase / Q000032:analysis*; D005260:Female; D010740:Phospholipases / Q000032:analysis*; D010741:Phospholipases A / Q000032:analysis*; D054467:Phospholipases A2; D010743:Phospholipids / Q000378:metabolism; D010770:Phosphotransferases / Q000032:analysis*; D011817:Rabbits
D010743:Phospholipids; D003566:Cytidine Diphosphate Choline; D010770:Phosphotransferases; D002798:Diacylglycerol Cholinephosphotransferase; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; D002794:Choline; D002118:Calcium