title: Acute and chronic effects of climbing fiber lesions on cerebellar cyclic guanosine monophosphate.
abstract: The neurotoxin 3-acetylpyridine was administered to 20-day-old rats to produce lesions of the inferior olive-climbing fiber projection to the cerebellum. Cerebellar cGMP levels were determined 6 h, 24 h, 48 h, 7 days, 14 days and 20 days postlesion. A significant effect on cGMP was found only at 48 h (-28%) and 7 days (-45%) postlesion. The results are discussed with respect to the cellular localization of cGMP and the hypothesized relationship of cGMP to cerebellar Purkinje cell activity.
authors.affiliation: Department of Pharmacology, University of Health Sciences, Chicago Medical School, IL 60064.
authors.forename: G A
authors.initials: GA
authors.lastname: Oltmans
authors.forename: L E
authors.initials: LE
authors.lastname: Moss
authors.forename: J F
authors.initials: JF
authors.lastname: Lorden
authors.forename: M
authors.initials: M
authors.lastname: Beales
mesh_terms: D000200:Action Potentials; D000818:Animals; D002531:Cerebellum / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D005260:Female; D008297:Male; D009412:Nerve Fibers / Q000502:physiology*; D009847:Olivary Nucleus / Q000502:physiology*; D011689:Purkinje Cells / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission; D013997:Time Factors
chemical_list: D006152:Cyclic GMP