title: Inhibition of growth of the dimorphic fungus Paracoccidioides brasiliensis by ajoene.
abstract: Ajoene, a garlic-derived compound that prevents platelet activation, inhibited the growth of Paracoccidioides brasiliensis, a fungal pathogen for humans, by affecting the integrity of the fungal cytoplasmic membrane. This action may be the basis for the study of ajoene as a possible specific antifungal drug.
authors.affiliation: Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Carcas, Venezuela.
authors.forename: G
authors.initials: G
authors.lastname: San-Blas
authors.forename: F
authors.initials: F
authors.lastname: San-Blas
authors.forename: F
authors.initials: F
authors.lastname: Gil
authors.forename: L
authors.initials: L
authors.lastname: Mariño
authors.forename: R
authors.initials: R
authors.lastname: Apitz-Castro
mesh_terms: D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D004220:Disulfides / Q000494:pharmacology*; D008854:Microscopy, Electron; D003904:Mitosporic Fungi; D010228:Paracoccidioides / Q000187:drug effects / Q000254:growth & development* / Q000648:ultrastructure; D010936:Plant Extracts / Q000494:pharmacology*; D013454:Sulfoxides; D013997:Time Factors
chemical_list: D004220:Disulfides; D010936:Plant Extracts; D013454:Sulfoxides; C048980:ajoene