title: Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes.
abstract: The tumor necrosis factor (TNF) alpha and beta gene pair has been linked in the human major histocompatibility complex to HLA-B, HLA-C, and, tentatively, HLA-E and HLA-A on one side and to the class III complement/steroid 21-hydroxylase gene cluster on the other by pulsed-field gel electrophoresis. The TNF genes are located 200 kilobases (kb) centromeric of HLA-B and about 350 kb telomeric of the class III cluster. Together with previous data on the linkage and structures of the class II and class III regions, a restriction map of the entire human major histocompatibility complex of about 3500 kb has been prepared.
authors.affiliation: Department of Pediatrics, Harvard Medical School, Boston, MA 02115.
authors.forename: M C
authors.initials: MC
authors.lastname: Carroll
authors.forename: P
authors.initials: P
authors.lastname: Katzman
authors.forename: E M
authors.initials: EM
authors.lastname: Alicot
authors.forename: B H
authors.initials: BH
authors.lastname: Koller
authors.forename: D E
authors.initials: DE
authors.lastname: Geraghty
authors.forename: H T
authors.initials: HT
authors.lastname: Orr
authors.forename: J L
authors.initials: JL
authors.lastname: Strominger
authors.forename: T
authors.initials: T
authors.lastname: Spies
mesh_terms: D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D003165:Complement System Proteins / Q000235:genetics*; D004262:DNA Restriction Enzymes; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006681:HLA-D Antigens / Q000235:genetics*; D006801:Humans; D008285:Major Histocompatibility Complex; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D006680:HLA Antigens; D006681:HLA-D Antigens; D014409:Tumor Necrosis Factor-alpha; D003165:Complement System Proteins; D004262:DNA Restriction Enzymes