title: Agonist-like effects of the benzodiazepine receptor antagonist RO 15-1788.
abstract: The present study investigated the effects of the benzodiazepine receptor antagonist RO 15-1788 on the ability to resist sleep after 1 night of sleep deprivation. Repeated administrations of RO 15-1788 to 6 subjects significantly decreased their ability to resist sleep in comparison with repeated administration of 100 mg of vitamin C, and with a nontreatment condition. Most of the hypnotic effect occurred 80-100 min after drug ingestion. RO 15-1788 also significantly enhanced sleep stage 2 spindles activity. These results demonstrate that at certain dosages RO 15-1788 has agonist-like effects.
authors.forename: P
authors.initials: P
authors.lastname: Lavie
authors.forename: R
authors.initials: R
authors.lastname: Peled
authors.forename: M
authors.initials: M
authors.lastname: Wollman
authors.forename: J
authors.initials: J
authors.lastname: Zomer
authors.forename: O
authors.initials: O
authors.lastname: Tzischinsky
mesh_terms: D000328:Adult; D001143:Arousal / Q000187:drug effects*; D005442:Flumazenil / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects*; D012892:Sleep Deprivation; D012894:Sleep Stages / Q000187:drug effects*
chemical_list: D011963:Receptors, GABA-A; D005442:Flumazenil