Effect of potassium on renal acidification and acid-base homeostasis.
In summary, altered potassium homeostasis can modify bicarbonate reabsorption by the proximal tubule and alter acidification by the distal nephron both by affecting proton transport in a primary fashion and by modifying renal ammonia production. With physiologic variations in dietary K+ intake, these processes may serve to sustain concurrent potassium and acid-base homeostasis. However, with pathologic degrees of potassium depletion and hyperkalemia, metabolic alkalosis and acidosis, respectively, can result.
Tannen
R L
RL
Division of Nephrology, University of Michigan Medical School, Ann Arbor 48109-0364.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000471:Alkalosis / Q000378:metabolism; D000641:Ammonia / Q000378:metabolism; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D004032:Diet; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D006947:Hyperkalemia / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology*; D011191:Potassium Deficiency / Q000378:metabolism
D001639:Bicarbonates; D000641:Ammonia; D011188:Potassium