Hu-ets-1 gene in congenital leukemia with t(11;19)(q23;p13).
Cytogenetic analysis of the leukemic cells from a 1-day-old baby with an acute myelomonocytic leukemia revealed them to contain a chromosome change of t(11;19)(q23;p13). Molecular studies using a 980 bp HindIII/HpaI digested v-ets probe showed no DNA rearrangements, deletions, or amplification in the leukemic cells, including the JH immunoglobulin and T-cell receptor (alpha or beta) genes. The findings indicate that the leukemic cells with t(11;19)(q23;p13) appear not to contain a transposition or rearrangement of the protooncogene Hu-ets-1 located at 11q23, as previously described in leukemic cells with t(4;11)(q21;q23) and t(9;11)(p22;q23). The leukemic cases with t(11;19)(q23;p13) studied by us showed a phenotype compatible with their myelomonocytic nature, although it is possible that other cases may have a lymphoid phenotype.
Ohyashiki
K
K
Department of Genetics, Roswell Park Memorial Institute, Buffalo.
Ohyashiki
J H
JH
Nomura
K
K
Ryan
D H
DH
Kinniburgh
A J
AJ
Sandberg
A A
AA
D002880:Chromosomes, Human, Pair 11; D002888:Chromosomes, Human, Pair 19; D004262:DNA Restriction Enzymes; D015246:Deoxyribonuclease EcoRI; D005803:Genes, Immunoglobulin; D006801:Humans; D007231:Infant, Newborn; D015470:Leukemia, Myeloid, Acute / Q000151:congenital* / Q000235:genetics; D008297:Male; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D014178:Translocation, Genetic
D011948:Receptors, Antigen, T-Cell; D004262:DNA Restriction Enzymes; D015246:Deoxyribonuclease EcoRI