N-myc amplified in retinoblastoma cell line FMC-RB1.
A recently described retinoblastoma cell line, FMC-RB1, showed a 16-fold N-myc oncogene amplification. The patient from whom the cell line was obtained died from an aggressive disease. It is suggested that N-myc amplification may be an adverse prognostic indicator.
Seshadri
R
R
Department of Haematology, Flinders Medical Centre, Bedford Park, South Australia.
Matthews
C
C
Norris
M D
MD
Brian
M J
MJ
D004262:DNA Restriction Enzymes; D015246:Deoxyribonuclease EcoRI; D005134:Eye Neoplasms / Q000235:genetics*; D005784:Gene Amplification; D006801:Humans; D009857:Oncogenes; D011379:Prognosis; D012175:Retinoblastoma / Q000235:genetics*; D014407:Tumor Cells, Cultured
D004262:DNA Restriction Enzymes; D015246:Deoxyribonuclease EcoRI