Distribution of opioid binding sites in spinal cord.
Opioid binding sites have been demonstrated in the spinal cords of four species (rat, guinea-pig, cow, pig). Similar numbers of sites, as measured with the unselective ligand [3H] bremazocine, are seen along the length of the rat spinal cord. Binding in the dorsal horn is three times greater than in ventral horn. The distribution of mu, delta and kappa sites is similar in all regions. The results are discussed in terms of reported distributions of peptides.
Traynor
J R
JR
Department of Chemistry, University of Technology, Loughborough, Leics., U.K.
Wood
M S
MS
D000818:Animals; D002417:Cattle; D006168:Guinea Pigs; D007700:Kinetics; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000378:metabolism*; D013045:Species Specificity; D013116:Spinal Cord / Q000378:metabolism*; D013552:Swine
D011957:Receptors, Opioid