Analysis of methylation of a human X located gene which escapes X inactivation.
The gene MIC2 is located in the pseudoautosomal region at the ends of the short arms of the X and Y chromosomes. In females MIC2 escapes X inactivation. We have analyzed the methylation pattern of MIC2 on the active X, the inactive X chromosomes, and the Y chromosome. The 5' end of the gene contains a GC rich region which is unmethylated on the active X, the inactive X and on the Y. The body of the gene is characterized by variable methylation.
Mondello
C
C
Istituto di Genetica Biochimica ed Evoluzionistica del CNR, Pavia, Italy.
Goodfellow
P J
PJ
Goodfellow
P N
PN
D001483:Base Sequence; D004262:DNA Restriction Enzymes / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007438:Introns; D008745:Methylation; D014960:X Chromosome; D014998:Y Chromosome
D004262:DNA Restriction Enzymes