w-oxidation products of leukotriene E4 in bile and urine of the monkey.
The intravenous administration of [3H]leukotriene C4 in the monkey Macaca fascicularis results in the biliary and urinary elimination of [3H]leukotriene D4 and [3H]leukotriene E4 in addition to more-polar metabolites. Separation of these polar metabolites and chromatographic comparison with synthetic w-oxidized leukotrienes indicated the in vivo formation of w-hydroxy-[3H]leukotriene E4 and w-carboxy-[3H]leukotriene E4. Time course studies of the [3H]leukotriene metabolite pattern in bile and urine showed that w-hydroxy-leukotriene E4 was decreasing as w-carboxy-leukotriene E4 and additional polar derivatives were increasing.
Ball
H A
HA
Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany.
Keppler
D
D
D000818:Animals; D001646:Bile / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D007700:Kinetics; D007975:Leukotriene B4 / Q000032:analysis* / Q000652:urine; D008252:Macaca fascicularis; D010084:Oxidation-Reduction; D013189:SRS-A / Q000378:metabolism
D013189:SRS-A; D007975:Leukotriene B4