[Action of phosphorus-containing aminocarboxylic acids on neuromuscular transmission in the blowfly].
The action of a series of phosphonic amino acids--glutamate receptor antagonists--on neuromuscular transmission in blowfly larva was studied under voltage clamp conditions. It was shown that 2-amino-4-phosphonobutyric acid decreases synaptic current in a dose-dependent manner, and 2-amino-7-phosphonoheptanoic acid increases its acting presynaptically. The analysis done shows that sensitivity of blowfly glutamate receptors to phosphonic amino acids differs from that in crustacean and mammalian glutamate receptors.
Grigor'ev
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VV
Ragulin
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VV
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000596:Amino Acids / Q000494:pharmacology*; D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D004175:Diptera / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005971:Glutamates / Q000502:physiology; D007814:Larva / Q000187:drug effects / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*
D000596:Amino Acids; D000613:Aminobutyrates; D005971:Glutamates; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D015763:2-Amino-5-phosphonovalerate; C012729:2-amino-4-phosphonobutyric acid; C031231:2-amino-7-phosphonoheptanoic acid
Deĭstvie fosforsoderzhashchikh aminokarbonovykh kislot na nervno-myshechnuiu peredachu u miasnoĭ mukhi.