[Effects of prenatal exposure to alcohol on the binding of H3-diazepam to the synaptic membranes of the cerebral hemisphere cortex at various stages of ontogenesis in the rat offspring].
Exposure to ethanol during pregnancy results in the alteration of (3H)-diazepam binding to synaptosomal neocortical membranes from the rat offspring. In male rats, 14 days of age, binding level diminished to 11%. In two-month-old control rats Scatchard plot was biphasic. It has been shown that prenatal exposure to ethanol leads to changes in the nature of binding in two-month-old experimental animals, as compared with the control ones. Possible relationship is discussed between the brain benzodiazepine system disorders and behaviour.
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D000367:Age Factors; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D003975:Diazepam / Q000378:metabolism*; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism*
D011963:Receptors, GABA-A; D000431:Ethanol; D003975:Diazepam
Vliianie prenatal'nogo vozdeĭstviia alkogolia na sviazyvanie 3H-diazepama s sinapticheskimi membranami kory bol'shikh poluchariĭ mozga na raznykh stadiiakh ontogeneza potomstva krys.