Genes for human vitamin K-dependent plasma proteins C and S are located on chromosomes 2 and 3, respectively.
cDNAs encoding human proteins C and S have been used to screen a panel of mouse-human somatic cell hybrids to determine the chromosomal location of their respective genes. The gene for human protein C is located on chromosome 2, whereas that for protein S is located on chromosome 3. Analysis of human genomic DNA restriction endonuclease fragmentation patterns suggests that the human protein S gene is greater than 40 kb in size and contains a minimum of 11 introns.
Long
G L
GL
Department of Biochemistry, College of Medicine, University of Vermont, Burlington 05405.
Marshall
A
A
Gardner
J C
JC
Naylor
S L
SL
D000818:Animals; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D004262:DNA Restriction Enzymes; D005819:Genetic Markers; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D011486:Protein C / Q000235:genetics*; D017293:Protein S
D005819:Genetic Markers; D006023:Glycoproteins; D011486:Protein C; D017293:Protein S; D004262:DNA Restriction Enzymes