title: High dose peptichemio in pretreated neuroblastoma.
abstract: The aim of this study was to evaluate the antitumor effect and toxicity of a single course of Peptichemio at high dose (450 mg/sq m) given to children with neuroblastoma resistant to first line treatment or at relapse. A total of 28 children were treated. Seven children showed partial response, 4 minor response, 8 had stable disease, and in 8 the tumor progressed. The principal toxic effect was myelosuppression. Hemorrhagic enteritis with liver failure and toxic death occurred in 1 patient. High dose Peptichemio can be administered with tolerable toxicity, inducing tumor regression in one third of previously treated patients.
authors.affiliation: Giannina Gaslini Children's Hospital, Genova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Garaventa
authors.forename: B
authors.initials: B
authors.lastname: De Bernardi
authors.forename: L
authors.initials: L
authors.lastname: Cordero Di Montezemolo
authors.forename: G
authors.initials: G
authors.lastname: Pastore
authors.forename: C
authors.initials: C
authors.lastname: De Laurentis
authors.forename: E
authors.initials: E
authors.lastname: Nardi
authors.forename: F
authors.initials: F
authors.lastname: Casale
authors.forename: A
authors.initials: A
authors.lastname: Mancini
authors.forename: G
authors.initials: G
authors.lastname: Loiacono
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001772:Blood Cell Count; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008558:Melphalan / Q000031:analogs & derivatives*; D009364:Neoplasm Recurrence, Local; D009447:Neuroblastoma / Q000188:drug therapy*; D010440:Peptichemio / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D010440:Peptichemio; D008558:Melphalan