title: Pharmacokinetics of a spin-labeled rubomycin analog.
abstract: Pharmacokinetics of a spin-labeled analog of rubomycin (ruboxyl) was studied. Differences were found in ruboxyl pharmacokinetics in normal and tumor-bearing animals. Most of the drug was excreted within 6 h. The differences in pharmacokinetics of ruboxyl and nitroxyl radical were established.
authors.affiliation: Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow.
authors.forename: N P
authors.initials: NP
authors.lastname: Konovalova
authors.forename: R F
authors.initials: RF
authors.lastname: Diatchkovskaya
authors.forename: G V
authors.initials: GV
authors.lastname: Kukushkina
authors.forename: L M
authors.initials: LM
authors.lastname: Volkova
authors.forename: V N
authors.initials: VN
authors.lastname: Varfolomeev
authors.forename: L S
authors.initials: LS
authors.lastname: Dombrovsky
authors.forename: A B
authors.initials: AB
authors.lastname: Shapiro
mesh_terms: D000818:Animals; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004578:Electron Spin Resonance Spectroscopy; D008099:Liver / Q000378:metabolism; D051379:Mice; D012510:Sarcoma 180 / Q000188:drug therapy / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: C042480:ruboxyl; D003630:Daunorubicin