Neuromuscular transmission studies in preeclamptic women receiving magnesium sulfate.
The purpose of the study was to evaluate the neuromuscular transmission defect in preeclamptic women receiving intravenous magnesium sulfate and to study the correlation of the degree of defect with serum magnesium and calcium levels. The study population included: group 1, 14 preeclamptic women receiving magnesium sulfate and undergoing induction of labor; group 2, six preeclamptic women studied in the postpartum period while receiving magnesium sulfate; and group 3, 10 normotensive women undergoing induction of labor. The neuromuscular transmission studies were performed with standard techniques before and during the administration of magnesium sulfate. During magnesium sulfate therapy patients in groups 1 and 2 showed abnormal responses characterized by an initial low-amplitude muscle action potential followed by a progressive increase in the amplitudes of the successive responses. There was significant correlation between the degree of the neuromuscular transmission defect and serum magnesium levels, serum calcium levels, and the magnesium/calcium ratio in groups 1 and 2. All studies were normal in group 3. The findings confirm the occurrence of abnormal neuromuscular transmission in preeclamptic women receiving magnesium sulfate, and the intensity of the defect correlates significantly with increased serum magnesium levels and decreased serum calcium levels.
Ramanathan
J
J
Department of Anesthesiology, University of Tennessee, Memphis.
Sibai
B M
BM
Pillai
R
R
Angel
J J
JJ
D000328:Adult; D001798:Blood Proteins / Q000032:analysis; D002118:Calcium / Q000097:blood; D004576:Electromyography; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D009469:Neuromuscular Junction / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D011247:Pregnancy; D009435:Synaptic Transmission / Q000187:drug effects
D001798:Blood Proteins; D008278:Magnesium Sulfate; D008274:Magnesium; D002118:Calcium