Regulation of IgE-dependent antiparasite functions of rat macrophages and platelets by nedocromil sodium.
The IgE-dependent stimulation of mononuclear phagocytes and blood platelets can be measured by antiparasite cytotoxicity, oxygen-mediated chemiluminescence and, in macrophages, lysosomal enzyme activity. Using these parameters, the present study demonstrated an inhibition by nedocromil sodium of the IgE-mediated triggering of the nonmast cell inflammatory populations in the rat. These observations suggest that nedocromil sodium may be of value in the modulation of IgE-dependent cell activation inducing the release of inflammatory mediators.
Thorel
T
T
Centre d'Immunologie et de Biologie Parasitaire, Unité mixte INSERM 167-CNRS 624, Institut Pasteur, Lille, France.
Joseph
M
M
Vorng
H
H
Capron
A
A
D000818:Animals; D001792:Blood Platelets / Q000276:immunology* / Q000378:metabolism; D002470:Cell Survival; D003602:Cytotoxicity, Immunologic; D005260:Female; D007073:Immunoglobulin E / Q000494:pharmacology*; D008163:Luminescent Measurements; D008247:Lysosomes / Q000201:enzymology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D017835:Nedocromil; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012550:Schistosoma mansoni / Q000187:drug effects*
D011804:Quinolines; D017835:Nedocromil; D007073:Immunoglobulin E