On the site of action of naloxone-stimulated cortisol secretion in gilts.
The increase in serum cortisol concentrations following naloxone administration to female pigs was abolished by hypophysial stalk-transection, even though CRH and ACTH stimulated cortisol release in these animals. We suggest that the opioid antagonist enhances cortisol secretion primarily by a central action in pigs.
Estienne
M J
MJ
Animal and Dairy Science Department, University of Georgia, Athens 30602.
Kesner
J S
JS
Barb
C R
CR
Kraeling
R R
RR
Rampacek
G B
GB
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D005260:Female; D006854:Hydrocortisone / Q000378:metabolism*; D007031:Hypothalamus / Q000502:physiology*; D009270:Naloxone / Q000494:pharmacology*; D010052:Ovariectomy; D010902:Pituitary Gland / Q000502:physiology*; D013552:Swine
D009270:Naloxone; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone