title: Sodium deficit causing decreased weight gain and metabolic acidosis in infants with ileostomy.
abstract: The records of 11 infants, 25 to 38 weeks' gestation, with metabolic abnormalities induced by ileostomy fluid losses were reviewed. At operation for necrotizing enterocolitis (NEC) (9) or meconium ileus (MI) (2), they weighed between 1,100 and 3,100 g and were from one to 41 days old. All developed total body sodium depletion and metabolic acidosis from ileostomy bicarbonate loss. In seven, sodium depletion was severe enough to require supplementation; six initially lost or failed to gain weight despite being fed adequate diet and calories. However, after receiving sodium supplementation (three with NaCl and three with NaHCO3), these six patients gained weight and improved their metabolic acidosis. The other five subjects did not initially receive sodium supplementation. Four gained weight; one of these later received supplemental NaHCO3 for a metabolic acidosis. The fifth patient failed to thrive until his ileostomy was closed. All infants initially had urine Na less than 10 mEq/L and normal serum Na. All infants whose urine Na rose above 10 mEq/L and had serum HCO3- greater than or equal to 20 mEq/L grew adequately. A direct relationship existed between ileostomy output and sodium intake required for growth. This expressed mathematically (Na intake = 1.2 + [0.13 x ileostomy output] shows a basal sodium need (with no ileostomy output) of 1.2 mEq/kg/d and an additional requirement of 0.13 mEq/kg/d of sodium for each mL/kg/d of ileostomy output. We conclude that infants with ileostomies are at extreme risk of total body sodium depletion with resultant metabolic acidosis and inadequate weight gain. These infants require sodium supplementation with a combination of NaCl and NaHCO3.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Surgery, University of Iowa Hospital and Clinics, Iowa City 52242.
authors.forename: T R
authors.initials: TR
authors.lastname: Bower
authors.forename: K C
authors.initials: KC
authors.lastname: Pringle
authors.forename: R T
authors.initials: RT
authors.lastname: Soper
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000209:etiology*; D001639:Bicarbonates / Q000008:administration & dosage; D001835:Body Weight / Q000187:drug effects; D006801:Humans; D007081:Ileostomy / Q000009:adverse effects*; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D012964:Sodium / Q000008:administration & dosage / Q000172:deficiency*; D017693:Sodium Bicarbonate; D012965:Sodium Chloride / Q000008:administration & dosage
chemical_list: D001639:Bicarbonates; D012965:Sodium Chloride; D017693:Sodium Bicarbonate; D012964:Sodium