Immune responses are required to terminate viremia in equine infectious anemia lentivirus infection.
Six normal and four immunodeficient horses were injected with a cloned variant of equine infectious anemia virus (EIAV). The six normal horses had detectable EIAV in their plasma by 7 days postinjection. During their primary viremic episode, which was accompanied by fever and anemia, maximum titers of EIAV in plasma ranged from 10(3.8) to 10(4.8) 50% tissue culture infective doses per ml. All six normal horses cleared detectable virus from their plasma by 21 to 35 days after injection. Horses with combined immunodeficiency became viremic by 9 days postinjection and also developed anemia. In contrast to normal horses, foals with combined immunodeficiency did not eliminate the virus from their plasma.
Perryman
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Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
O'Rourke
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McGuire
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D000818:Animals; D004859:Equine Infectious Anemia / Q000276:immunology* / Q000382:microbiology; D006736:Horses; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D004860:Infectious Anemia Virus, Equine / Q000276:immunology*; D014766:Viremia / Q000276:immunology