In vitro and in vivo effect of chloropromazine, imipramine and lithium chloride on monoamine oxidase activity in rat brain mitochondria.
Chloropromazine (CPZ) and imipramine at a concentration of 1 x 10(-3) M inhibit rat brain mitochondrial monoamine oxidase activity in vitro by 70 and 55% respectively, while lithium, even at a concentration of 0.05 M, inhibits the activity of this enzyme very negligibly (4%). In vivo, these drugs at a dose level of 56 mg CPZ, 76 mg imipramine and 76 mg lithium chloride/Kg body wt., did not cause any observable variation from normal in brain mitochondrial monoamine oxidase activity.
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Indian Institute of Chemical Biology, Jadavpur, Calcutta.
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D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002712:Chlorides / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D008995:Monoamine Oxidase / Q000378:metabolism*; D051381:Rats
D002712:Chlorides; D008094:Lithium; D008995:Monoamine Oxidase; D018021:Lithium Chloride; D007099:Imipramine; D002746:Chlorpromazine