title: Cerebral ischemia decreases endogenous calcium-dependent protein phosphorylation in gerbil brain.
abstract: Acute forebrain ischemia in the gerbil produced a significant decrease in endogenous Ca2+-dependent hippocampal protein phosphorylation in comparison to sham and naive control animals. Inhibition of Ca2+-dependent phosphorylation was demonstrated as early as 2 h post-ischemia and shown to persist up to 7 days following the ischemic insult. The ischemia-induced loss of Ca2+-dependent phosphorylation was only seen in brain regions affected by the localized ischemia and not in non-ischemic brain regions from the same animal. These results suggest that an early event in the development of ischemia-induced neuronal death is a decrease in Ca2+-dependent protein phosphorylation.
authors.affiliation: Department of Neurology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
authors.forename: W C
authors.initials: WC
authors.lastname: Taft
authors.forename: K A
authors.initials: KA
authors.lastname: Tennes-Rees
authors.forename: R E
authors.initials: RE
authors.lastname: Blair
authors.forename: G L
authors.initials: GL
authors.lastname: Clifton
authors.forename: R J
authors.initials: RJ
authors.lastname: DeLorenzo
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology*; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D005849:Gerbillinae; D002546:Ischemic Attack, Transient / Q000201:enzymology*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009928:Organ Specificity; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D012016:Reference Values
chemical_list: D009419:Nerve Tissue Proteins; D011494:Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases