title: Fluconazole penetration into cerebrospinal fluid in humans.
abstract: One hour after intravenous doses of 50 mg/d fluconazole for 6 days or 100 mg/d for seven days to healthy subjects, the cerebrospinal fluid concentrations of fluconazole were 1.26 mg/L and 2.74 mg/L, respectively. These values were approximately 52% and 62% those of serum. Four patients with an initial clinical diagnosis of meningitis also had significant concentrations of fluconazole in the cerebrospinal fluid.
authors.affiliation: Central Research Division, Pfizer Inc., Groton, Connecticut 06340.
authors.forename: G
authors.initials: G
authors.lastname: Foulds
authors.forename: D R
authors.initials: DR
authors.lastname: Brennan
authors.forename: C
authors.initials: C
authors.lastname: Wajszczuk
authors.forename: A
authors.initials: A
authors.lastname: Catanzaro
authors.forename: D C
authors.initials: DC
authors.lastname: Garg
authors.forename: W
authors.initials: W
authors.lastname: Knopf
authors.forename: M
authors.initials: M
authors.lastname: Rinaldi
authors.forename: D J
authors.initials: DJ
authors.lastname: Weidler
mesh_terms: D015725:Fluconazole; D006207:Half-Life; D006801:Humans; D007262:Infusions, Intravenous; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D014230:Triazoles / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid* / Q000494:pharmacology
chemical_list: D014230:Triazoles; D015725:Fluconazole