title: Initial experience with Tc-99m-HM-PAO in the study of brain tumors.
abstract: A preliminary study of the distribution of the 99mTc complex of hexamethylpropylene amine oxime (HM-PAO) in 12 patients with brain neoplasms before, during, and after radiotherapy has been performed. Untreated brain tumors were found to exhibit a range of 99mTc-HM-PAO uptake, varying from areas of markedly increased isotope activity to photopenic areas, when compared to normal brain tissue. A ratio of 99mTc-HM-PAO tumor uptake to contralateral normal tissue uptake was calculated prior to and during radiotherapy. This ratio tended to return towards unity in lesions responding to therapy. A predictable alteration in whole brain 99mTc-HM-PAO uptake during radiotherapy was not demonstrated. Unlike the radiolabeled amines, 99mTc-HM-PAO localizes in primary tumors, probably indicating that its uptake mechanism is independent of non specific amine receptors. 99mTc-HM-PAO may be useful in the study of brain tumor physiology and response to therapy.
authors.affiliation: Department of Medical Physics, Royal Marsden Hospital, Sutton, Surrey, UK.
authors.forename: J W
authors.initials: JW
authors.lastname: Babich
authors.forename: F
authors.initials: F
authors.lastname: Keeling
authors.forename: M A
authors.initials: MA
authors.lastname: Flower
authors.forename: L
authors.initials: L
authors.lastname: Repetto
authors.forename: A
authors.initials: A
authors.lastname: Whitton
authors.forename: S
authors.initials: S
authors.lastname: Fielding
authors.forename: A
authors.initials: A
authors.lastname: Fullbrook
authors.forename: R J
authors.initials: RJ
authors.lastname: Ott
authors.forename: V R
authors.initials: VR
authors.lastname: McCready
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D002283:Carcinoma, Bronchogenic / Q000000981:diagnostic imaging / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000556:secondary; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed
chemical_list: D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime