Suppression of humoral immune response against herpes simplex virus induced by defective strains, ts- and TK- mutants.
Suppression of humoral antibody formation against HSV is not only induced by replicating Herpes simplex virus type 2 (HSV-2) but also by the defective strain ANG and the deletion mutant 1301 of Herpes simplex virus type 1 (HSV-1). Moreover, ts-mutants A, H, K, S, 1201 and 1208 of HSV-1 as well as some ts-mutants of HSV-2 and "defective-interfering" particles of HSV-1 after high multiplicity of infection-passages induced suppression. Treatment of infected mice with ACG reduced antibody-formation but did not result in suppression. UV-irradiation of the antibody producing strain Len of HSV-1 strongly reduces antibody formation and induces suppression. Experiments using a series of intertypic recombinants showed the suppressing activity to be spread over the whole genome of HSV-2. It is concluded that suppression is induced by more than one region of the genome of HSV-2 and by incomplete replication of HSV-1 and 2.
Metzger
B
B
Division of Experimental Virology, Johannes Gutenberg University, Mainz, Federal Republic of Germany.
Podlech
J
J
Müller
S
S
Falke
D
D
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D003673:Defective Viruses / Q000276:immunology; D005814:Genes, Viral; D007108:Immune Tolerance; D051379:Mice; D009154:Mutation; D011995:Recombination, Genetic; D018139:Simplexvirus / Q000235:genetics / Q000276:immunology*; D013937:Thymidine Kinase / Q000235:genetics; D014762:Viral Interference; D014779:Virus Replication
D000914:Antibodies, Viral; D013937:Thymidine Kinase