Comparative study of mitogenic responses in man and Japanese monkeys (Macaca fuscata): responses of T-cell subsets, accessory cell dependency, and interleukin-2 receptor expression.
Responses of peripheral blood mononuclear cells to phytohemagglutinin-P (PHA-P), concanavalin-A (ConA), and pokeweed mitogen (PWM) were compared in man and Japanese monkeys. Both CD8+ and CD8- T subsets showed greater responses to ConA than to PHA-P in the Japanese monkey. Addition of macrophages to each T subset produced more effective augmentation of ConA response in the Japanese monkey than in man, and ConA induced more interleukin-2-receptor-positive blast cells than PHA-P did in Japanese monkeys.
Murayama
Y
Y
Primate Research Institute, Kyoto University, Aichi, Japan.
Noguchi
A
A
Takenaka
O
O
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D017977:Deltaretrovirus / Q000276:immunology; D005434:Flow Cytometry; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008251:Macaca / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008934:Mitogens / Q000494:pharmacology*; D011971:Receptors, Immunologic / Q000096:biosynthesis*; D015375:Receptors, Interleukin-2; D012190:Retroviridae / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000914:Antibodies, Viral; D007376:Interleukin-2; D008934:Mitogens; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2