A single icv injection of KCl induces a selective and long-lasting inhibition of opioid analgesia in mice.
The icv administration of potassium chloride a few min before the icv injection of opioids, antagonized the supraspinal analgesia induced by these substances in the mouse. The antagonistic effect of a single injection of KCl lasted for 3 to 4 days and was accompanied by opposite changes in 3H-DADLE binding to mesencephalic (decrease) and spinal cord (increase) membranes.
Garzón
J
J
Department of Neuropharmacology, Cajal Institute, Madrid, Spain.
Sánchez-Blázquez
P
P
D000698:Analgesia; D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004745:Enkephalins / Q000494:pharmacology*; D007276:Injections, Intraventricular; D051379:Mice; D009294:Narcotics / Q000494:pharmacology*; D011189:Potassium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D004745:Enkephalins; D009294:Narcotics; D011957:Receptors, Opioid; D012965:Sodium Chloride; D011189:Potassium Chloride