The use of post-binding agents in studying insulin action and its relation to experimental diabetes.
This review includes data related to two substances that modulate insulin mechanisms, both in vitro and in the whole animal model. It seems to us that these agents (vanadate and PMXB) will be of potential use in the next decade for basic and applied research. They may assist in characterizing the essential post-binding events involved in insulin action, which cannot presently be identified. As vanadate and PMXB modulate the effects of insulin both in vivo and in vitro, they may be of use in clinical and pathophysiological research as well. VO3- is a low molecular weight substance which permeates the intestinal tract and mimics the actions of insulin in target tissues. Studies that were summarized here may even suggest that VO3- is superior to insulin in stimulating its effects in tissues that are down-regulated or desensitized to the hormone itself. Both VO3- and PMXB may be useful in the treatment of diabetes in the future if long-range toxicity studies prove these agents to be clinically safe. PMXB has already been in use in medicine for several decades now.
Shechter
Y
Y
Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.
Meyerovitch
J
J
Amir
S
S
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D011112:Polymyxin B / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*; D014639:Vanadium / Q000494:pharmacology*
D007328:Insulin; D011113:Polymyxins; D014639:Vanadium; D005947:Glucose; D011112:Polymyxin B