Cytomegalovirus infection after autologous bone marrow transplantation with comparison to infection after allogeneic bone marrow transplantation.
Cytomegalovirus (CMV) infection was detected in 65 of 143 (45%) autologous bone marrow transplant (BMT) patients. CMV pneumonitis occurred in only 2% of the patients and CMV retinitis occurred in none. Infection occurred in half of the 40 initially seronegative patients and 47% of the 94 initially seropositive patients. Among initially seropositive patients, platelet recovery was slower in infected patients than in those not infected (97 v 35 days median, P = .003), and neutrophil recovery was slightly delayed in infected patients (31 days v 24 days, P = .02). Although the incidence of CMV infection was comparable in autologous and allogeneic BMT patients, CMV pneumonitis was less frequent in autologous BMT patients (2% v 12%, P less than .001). The risk for CMV pneumonitis in autologous BMT patients was comparable with that in allogeneic BMT patients without graft-v-host disease (GVHD) (2% v 6%), but significantly lower than the risk in allogeneic BMT patients with GVHD (2% v 23%, P less than .001).
Wingard
J R
JR
Oncology Center, Johns Hopkins Medical Institutions, Baltimore, MD.
Chen
D Y
DY
Burns
W H
WH
Fuller
D J
DJ
Braine
H G
HG
Yeager
A M
AM
Kaiser
H
H
Burke
P J
PJ
Graham
M L
ML
Santos
G W
GW
D016026:Bone Marrow Transplantation; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000209:etiology*; D006086:Graft vs Host Disease; D006801:Humans; D007958:Leukocyte Count; D008396:Maryland; D010976:Platelet Count; D011024:Pneumonia, Viral / Q000453:epidemiology / Q000209:etiology; D011183:Postoperative Complications / Q000453:epidemiology*; D012173:Retinitis / Q000453:epidemiology / Q000209:etiology; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014775:Virus Activation