The cis-trans effects of crossing-over on the penetrance and expressivity of dominantly inherited disorders.
A surprisingly simple model based on the cis-trans effects of meiotic and mitotic crossing-over is proposed to explain apparent non-penetrance and reduced expressivity in dominantly inherited disorders. Sex differences, discordant monozygotic twins, multifactorial inheritance and allelism are also discussed.
Côté
G B
GB
Genetics Division, Institute of Child Health, Athens, Greece.
D000483:Alleles; D003434:Crossing Over, Genetic; D004200:Diseases in Twins; D004843:Epistasis, Genetic; D005260:Female; D005799:Genes, Dominant; D030342:Genetic Diseases, Inborn / Q000235:genetics* / Q000473:pathology; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008297:Male; D008540:Meiosis; D008938:Mitosis; D008957:Models, Genetic; D009030:Mosaicism; D011995:Recombination, Genetic; D014430:Twins, Monozygotic