title: Effect of dietary supplementation with n-3 fatty acids on clinical manifestations of psoriasis.
abstract: In a double-blind, block randomized study we investigated the effect of dietary supplementation with eicosapentaenoic acid in patients with psoriasis. The experimental group received 10 g of fish oil daily containing approximately 1.8 g eicosapentaenoic acid, while the controls were given an isoenergetic amount of olive oil. We found no significant change in the clinical manifestations of psoriasis in either group after 8 weeks of treatment. In the experimental group, the amount of n-3 fatty acids in serum phospholipids was significantly increased at the end of trial as compared to pre-treatment values, whereas the level of n-6 fatty acids was decreased.
authors.affiliation: Department of Dermatology, Ullevål University Hospital, Oslo, Norway.
authors.forename: A
authors.initials: A
authors.lastname: Bjørneboe
authors.forename: A K
authors.initials: AK
authors.lastname: Smith
authors.forename: G E
authors.initials: GE
authors.lastname: Bjørneboe
authors.forename: P O
authors.initials: PO
authors.lastname: Thune
authors.forename: C A
authors.initials: CA
authors.lastname: Drevon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004032:Diet; D004311:Double-Blind Method; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D011897:Random Allocation
chemical_list: D015118:Eicosapentaenoic Acid