In vitro activities of azithromycin (CP 62,993), clarithromycin (A-56268; TE-031), erythromycin, roxithromycin, and clindamycin.
The in vitro activity of azithromycin (CP 62,993 or XZ-450) against Haemophilus influenzae was greater than that of three other macrolides. However, azithromycin was four- to eightfold less active than erythromycin against the gram-positive cocci and against Listeria monocytogenes. Erythromycin and azithromycin were similar in their activity against Legionella pneumophila, Neisseria gonorrhoeae, Neisseria meningitidis, and Branhamella catarrhalis.
Barry
A L
AL
Clinical Microbiology Institute, Tualatin, Oregon 97062.
Jones
R N
RN
Thornsberry
C
C
D017963:Azithromycin; D001419:Bacteria / Q000187:drug effects*; D017291:Clarithromycin; D002981:Clindamycin / Q000494:pharmacology*; D003470:Culture Media; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000031:analogs & derivatives / Q000494:pharmacology*; D006193:Haemophilus influenzae / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007933:Leucomycins / Q000494:pharmacology
D003470:Culture Media; D007933:Leucomycins; D002981:Clindamycin; D004917:Erythromycin; D017963:Azithromycin; D017291:Clarithromycin