[Relation between human papillomavirus (HPV) and cancer of uterine cervix].
HPV-DNA fragments were detected in biopsy specimens (29 cases of cancer of uterine cervix, 2 cervical dysplasia and 9 normal cervix) using DNA hybridization technique. It was demonstrated that 52% of biopsy specimens of the cancer of uterine cervix was positive for HPV 16 DNA probe, while 9% was positive for HPV 18 DNA probe. 11% of non-cancerous biopsy specimens had a positive result for HPV 16 DNA probe. It was also demonstrated that the positive rate of HPV 16 DNA was 75% in grossly cauliflower and nodular type tumors but only 25% in erosion type. It seems that the positive rate of HPV 16 DNA is correlated to gross appearance of the tumor. The positive rates of HPV 16 DNA were different in 6 provinces in China. It was 64% in Shanxi Province, a high incidence area but 36% in Sichuan Province, a low incidence area. These results suggest that the carcinogenesis of cancer of the uterine cervix, be related to HPV infection.
Zhang
W H
WH
Cancer Hospital and Institute, Chinese Academy of Medical Sciences, Beijing.
Wu
A R
AR
Li
J X
JX
Lin
Y C
YC
D000368:Aged; D002278:Carcinoma in Situ / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000032:analysis; D002584:Cervix Uteri / Q000382:microbiology*; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae; D010446:Peptide Fragments / Q000032:analysis*; D012689:Sequence Homology, Nucleic Acid; D002578:Uterine Cervical Dysplasia / Q000032:analysis; D002583:Uterine Cervical Neoplasms / Q000032:analysis*
D004279:DNA, Viral; D010446:Peptide Fragments