title: On the radiochemical quality control of [123I] sodium iodide for thyroid scanning.
abstract: Use of [123I]sodium iodide of too high specific activity in preparations for the diagnosis of disorders of the thyroid can lead to erroneous values for protein bound iodine and 24 h iodine uptake in the thyroid. Commonly used radiochemical quality control methods such as thin layer chromatography and the procedure described in the 21st edition of the U.S. Pharmacopoeia failed to reveal impurities in such preparations. A simple and quick check method is described, for indicating preparations unsuitable for diagnosis of thyroid disorders.
authors.affiliation: Department of Pharmacy, Ignatius Hospital, Breda, The Netherlands.
authors.forename: B M
authors.initials: BM
authors.lastname: van der Kleij
authors.forename: A M
authors.initials: AM
authors.lastname: Vermeulen
authors.forename: C
authors.initials: C
authors.lastname: Cornelisse
mesh_terms: D006801:Humans; D006980:Hyperthyroidism / Q000000981:diagnostic imaging; D007454:Iodides; D007457:Iodine Radioisotopes; D011786:Quality Control; D011877:Radionuclide Imaging; D012016:Reference Values; D012974:Sodium Iodide / Q000592:standards; D013961:Thyroid Gland / Q000000981:diagnostic imaging*
chemical_list: D007454:Iodides; D007457:Iodine Radioisotopes; D012974:Sodium Iodide