Latent herpes simplex virus type 1 transcription in human trigeminal ganglia.
We studied latent herpes simplex virus type 1 gene expression in human trigeminal ganglia. Two transcripts were mapped to a 3.0-kilobase region within the long repeat region and appeared to be located in neuronal nuclei. These viral RNAs were not abundant during lytic replication and may represent an alternative pattern of herpes simplex virus type 1 gene expression involved in the pathogenesis of latent infection.
Steiner
I
I
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.
Spivack
J G
JG
O'Boyle
D R
DR
Lavi
E
E
Fraser
N W
NW
D000328:Adult; D000368:Aged; D004262:DNA Restriction Enzymes; D005260:Female; D005786:Gene Expression Regulation; D006561:Herpes Simplex / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000032:analysis; D012091:Repetitive Sequences, Nucleic Acid; D018139:Simplexvirus / Q000235:genetics*; D014158:Transcription, Genetic; D012668:Trigeminal Ganglion / Q000382:microbiology*; D014276:Trigeminal Nerve / Q000382:microbiology*
D012367:RNA, Viral; D004262:DNA Restriction Enzymes