Enhanced AKR leukemogenesis by the dual tropic viruses. II. Effect on cell-mediated immune responses.
We examined the relationship of the leukemia-accelerating properties of a dual-tropic virus (DTV-70) (when injected into the thymus of 14-day-old AKR mice) to its ability to impair T cell functions. Splenic lymphocytes from virus-infected AKR mice were found to have reduced T cell mitogenic responses; moreover, these cells suppressed phytohemagglutinin stimulation of cells from normal, uninfected AKR mice. The response to the B cell mitogen lipopolysaccharide was slightly enhanced at 15 days following DTV-70 infection and was unaffected at later ages. AKR mice infected with DTV-70 showed reduced ability to develop delayed-type hypersensitivity reaction and interleukin 2 production. In contrast, spleen cells from the virus-infected mice responded normally to allogeneic stimulation in mixed lymphocyte culture and mounted an almost normal graft versus host reaction. The data suggest that DTV-70 impairs certain T cell functions that could interfere with immune surveillance and thus permit progression of preleukemic cells into overt leukemia. These T cell functions are suppressed normally by 6 months of age, perhaps by spontaneously arising DTV.
Peled
A
A
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
Hoffman
A D
AD
Levy
J A
JA
Haran-Ghera
N
N
D000367:Age Factors; D000818:Animals; D005260:Female; D006087:Graft vs Host Reaction; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*