Opiate receptor binding and behavioral effects of morphine in RHA/Verh and RLA/Verh rats.
Large baseline differences were found in open field activity and rearing behavior between 2 psychogenetically selected rat lines, as well as differences in the effects of peripherally administered morphine (2,4 and 10 mg/kg) on those behaviors and on body temperature. The 2 lines also showed different capacities of tritiated DAGO binding to preparations of striatal membranes.
Lazega
D
D
Inst. of Pharmacology, Univ. of Zurich, Switzerland.
Driscoll
P
P
Frischknecht
H R
HR
Siegfreid
B
B
Waser
P G
PG
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000378:metabolism; D016308:Enkephalin, Leucine-2-Alanine; D004745:Enkephalins / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011922:Rats, Mutant Strains; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D013045:Species Specificity
D004745:Enkephalins; D011957:Receptors, Opioid; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D009020:Morphine