title: The suprachiasmatic nuclei stimulate evening ACTH secretion in the rat.
abstract: The effect of bilateral lesions of the suprachiasmatic nuclei (SCN) on the circadian rhythm in ACTH was studied in rats that were adrenalectomized and implanted with a subcutaneous corticosterone (B) pellet. Rats wee chronically cannulated to allow for repeated blood sampling. In rats with B pellets, bilateral lesions of the SCN eliminated the circadian rise in plasma ACTH seen in sham-lesioned animals. This is consistent with the idea that the SCN stimulate ACTH secretion in the evening.
authors.affiliation: Department of Physiology, University of California School of Medicine, San Francisco 94143.
authors.forename: C S
authors.initials: CS
authors.lastname: Cascio
authors.forename: J
authors.initials: J
authors.lastname: Shinsako
authors.forename: M F
authors.initials: MF
authors.lastname: Dallman
mesh_terms: D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D002940:Circadian Rhythm; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology; D004343:Drug Implants; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013493:Suprachiasmatic Nucleus / Q000502:physiology*
chemical_list: D004343:Drug Implants; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone