Stimulation of D2-receptors in rat nucleus accumbens slices inhibits dopamine and acetylcholine release but not cyclic AMP formation.
We compared some functional responses of D1- and D2-receptor stimulation in tissue slices of rat neostriatum with those in slices of the nucleus accumbens. In both brain regions D2-receptor stimulation inhibited the electrically evoked release of radiolabeled dopamine and acetylcholine. In both brain regions D1-receptor stimulation and forskolin increased the cyclic AMP formation. Only in the neostriatum, stimulation of D2-receptors inhibited the formation of cyclic AMP, brought about by forskolin or by D1-receptor stimulation. It is concluded from these experiments that, although functional responses of D2-receptor stimulation can be demonstrated in the nucleus accumbens, D2-receptors in this brain region are apparently uncoupled to adenylate cyclase.
Stoof
J C
JC
Department of Neurology, Medical Faculty, Free University, Amsterdam, The Netherlands.
Verheijden
P F
PF
Leysen
J E
JE
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D005576:Colforsin / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D000242:Cyclic AMP / Q000096:biosynthesis*; D004298:Dopamine / Q000378:metabolism*; D018492:Dopamine Antagonists; D004873:Ergolines / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D019257:Quinpirole; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D012686:Septal Nuclei / Q000502:physiology*; D013469:Sulpiride / Q000494:pharmacology*
D001552:Benzazepines; D018492:Dopamine Antagonists; D004873:Ergolines; D011954:Receptors, Dopamine; D005576:Colforsin; D019257:Quinpirole; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D013469:Sulpiride; D000242:Cyclic AMP; D000109:Acetylcholine; D004298:Dopamine