title: Alcohol consumption alters the pharmacodynamics of alfentanil.
abstract: Two groups of women, ASA physical status 1, undergoing surgery for primary breast cancer, were studied to assess the effect of alcohol intake on alfentanil pharmacodynamics. Patients in group 1 (n = 6) had an average daily consumption of 20-40 g alcohol. Patients in group 2 (n = 8) were life-long abstainers or drank only occasionally (less than 60 g per year). Anesthesia was induced and maintained with 66% N2O in O2 and alfentanil. Alfentanil was administered by a computer-controlled infusion pump. If during surgery the patient exhibited somatic, hemodynamic, or other autonomic signs of inadequate anesthesia (response), the target alfentanil plasma concentration was increased by 50-100 ng/ml. If there was no response during a 15-min period, the target concentration was decreased by 50-100 ng/ml. Arterial blood samples were taken before any change of the target concentration, 4 min after a new predicted target concentration was achieved, and at extubation. Plasma concentrations were determined by capillary gas chromatography. Alfentanil protein binding was measured by equilibrium dialysis. Plasma alfentanil concentration-effect data were analyzed by nonlinear regression, where effect was either response or no response to surgical stimuli. The average total alfentanil requirement was significantly (P less than 0.005) higher in group 1 (3.7 +/- 1.2 micrograms.kg-1.min-1) than in group 2 (1.9 +/- 0.4 micrograms.kg-1.min-1). The average Cp50 (the plasma concentration for which the probability of no response during surgery is 50%) was significantly (P less than 0.001) higher in group 1 (522 +/- 104 ng/ml) than in group 2 (208 +/- 26 ng/ml).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesiology, University Hospital, Leiden, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: Lemmens
authors.forename: J G
authors.initials: JG
authors.lastname: Bovill
authors.forename: P J
authors.initials: PJ
authors.lastname: Hennis
authors.forename: M P
authors.initials: MP
authors.lastname: Gladines
authors.forename: A G
authors.initials: AG
authors.lastname: Burm
mesh_terms: D000428:Alcohol Drinking; D015760:Alfentanil / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D003243:Consciousness / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009270:Naloxone / Q000627:therapeutic use; D009994:Osmolar Concentration; D012119:Respiration / Q000187:drug effects
chemical_list: D015760:Alfentanil; D009270:Naloxone