[Synthesis of 7-(4,7-di-substituted coumarin-3-acetamido)cephalosporins].
Seventeen derivatives of 7-(4,7-di-substituted coumarin-3-acetamido)cephalosporins were synthesized with acid chloride method, Vilsmeier reagent method and mixed anhydride method. Isolation and purification were fulfilled with Sephadex LH-20 column chromatography and centrifugal-TLC technique. Their chemical structures were identified by elemental analysis, IR and 1HNMR spectrum. The preliminary antibacterial activity tests showed that these cephalosporin derivatives exhibited good activity against Gram-positive bacteria and individual Gram-negative bacteria. Further experiments in pharmacology will be made.
Fan
H J
HJ
Duan
T H
TH
Li
M H
MH
D002511:Cephalosporins / Q000138:chemical synthesis*; D003374:Coumarins / Q000138:chemical synthesis*
D002511:Cephalosporins; D003374:Coumarins