title: Possible involvement of interferon alfa in the pathogenesis of fever in systemic lupus erythematosus.
abstract: Serum concentrations of interferon alfa, interleukin 1, and tumour necrosis factor alpha were measured in 25 untreated patients with systemic lupus erythematosus (SLE). A close correlation was found between serum concentrations of interferon alfa and the degree of fever, while no significant correlations were found between fever and interleukin 1 or tumour necrosis factor alpha. These results suggest the possible involvement of interferon alfa in the pathogenesis of fever in SLE.
authors.affiliation: First Department of Internal Medicine, Osaka City University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kanayama
authors.forename: T
authors.initials: T
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Inariba
authors.forename: N
authors.initials: N
authors.lastname: Negoro
authors.forename: M
authors.initials: M
authors.lastname: Okamura
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: T
authors.initials: T
authors.lastname: Inoue
mesh_terms: D005334:Fever / Q000097:blood / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007370:Interferon Type I / Q000097:blood / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*
chemical_list: D007370:Interferon Type I