Adrenal androgen secretion and dopaminergic activity in anorexia nervosa.
The aim of the present study was to investigate if the postulated deficient adrenal androgen secretion in Anorexia Nervosa (AN), could be associated with a status of sustained dopaminergic hyperactivity. The adrenal responses to ACTH and PRL response to dopaminergic receptor blockade were studied in seven patients with Anorexia Nervosa and seven regularly menstruating women. AN patients showed lower baseline DHEA-sulphate (DHEA-S), androstenedione (Adione) and prolactin (PRL) levels than controls. The response to ACTH revealed evidences of significantly decreased 17-20 desmolase activity in AN, with apparent predominance of glucocorticoid over androgenic pathways relative to controls. Because dopaminergic receptor blockade with Domperidone (DOM) showed intense dopaminergic hyperactivity in AN, we postulate that the adrenal regression seen in the disease is the consequence of a reduced zona reticularis as a consequence of the lack of trophic support by PRL and/or intermediate lobe proopiomelanocortin (IL-POMC). This is consistent with our previous results in pre-adrenarchal dogs and rabbits.
Devesa
J
J
Lab. de Neurociencias Ramón Dominguez, Dept. of Physiology, Faculty of Medicine, Santiago de Compostela, Spain.
Pérez-Fernández
R
R
Bokser
L
L
Gaudiero
G J
GJ
Lima
L
L
Casanueva
F F
FF
D000293:Adolescent; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone; D000328:Adult; D000728:Androgens / Q000378:metabolism*; D000735:Androstenedione / Q000378:metabolism; D000856:Anorexia Nervosa / Q000503:physiopathology*; D003687:Dehydroepiandrosterone / Q000378:metabolism; D004294:Domperidone / Q000494:pharmacology; D005260:Female; D006801:Humans; D011388:Prolactin / Q000378:metabolism; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*
D000728:Androgens; D011954:Receptors, Dopamine; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D004294:Domperidone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin