Hemopoietic growth factors and their interactions with specific receptors.
Four hemopoietic growth factors (colony-stimulating factors--CSF's) interact with committed progenitors of granulocytes and macrophages to control their survival, proliferation, differentiation, and functional activation of the mature cells. All four growth factors have now been purified and cloned, and their human equivalents identified and cloned. In this review the most important characteristics of the biological specificities of each CSF are described and correlated with what has been learned about the interactions of the CSF's with specific cellular receptors.
Nicola
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Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D003115:Colony-Stimulating Factors / Q000378:metabolism / Q000494:pharmacology*; D004347:Drug Interactions; D006133:Growth Substances / Q000378:metabolism / Q000494:pharmacology*; D016298:Hematopoietic Cell Growth Factors; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism; D016184:Receptors, Colony-Stimulating Factor; D013329:Structure-Activity Relationship
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D016298:Hematopoietic Cell Growth Factors; D011956:Receptors, Cell Surface; D016184:Receptors, Colony-Stimulating Factor