[Type-II alveolocytes in the treatment of the pulmonary form of oxygen poisoning (electron microscopic and morphometric research)].
The effect of cytochrome C, thymalin and their combination has been studied concerning morphofunctional state of alveolocytes of the II type (A II) in the lungs of 33 non-inbred white rats at the pulmonary form of oxygen poisoning. The phenomenon develops, when the animals are in pure oxygen under pressure of 0.25 MPa for 10 h. The ultrastructural stereological analysis demonstrates that after exposure of the mice in the barochamber, immediately after decompression and during the 1st and the 3d day in the animals not given the pharmacological preparations in the A II diffuse and local edema develops in hyaloplasm, certain changes develop in mitochondria and endoplasmic reticulum. Comparing to intact animals, a relative volume of the lamellar bodies decreases nearly two times, the volume of mitochondria increases by 1.5 times, amount of A II drops. While treating the pulmonary form of oxygen poisoning with cytochrome C or thymalin, in 3 days after beginning to administer the preparations, the relative volume of the lamellar bodies increase by 1.5 times in comparison with those in the group of untreated animals, and at the combined administration-by 2.5 times. This demonstrates stimulation of the pulmonary surfactant synthesis. When the preparations are applied together, by the 3d day the relative volume of mitochondria and amount of A II do not differ from the corresponding indices in intact animals.
Zaĭtseva
K K
KK
Grigor'eva
Iu A
IuA
Lotovin
A P
AP
D000818:Animals; D001273:Atmosphere Exposure Chambers; D003574:Cytochrome c Group / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D008171:Lung Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D008854:Microscopy, Electron; D010100:Oxygen / Q000506:poisoning*; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000648:ultrastructure; D013951:Thymus Hormones / Q000627:therapeutic use; D013997:Time Factors
D003574:Cytochrome c Group; D013951:Thymus Hormones; C032805:thymalin; D010100:Oxygen
Al'veolotsity II tipa pri lechenii legochnoĭ formy otravleniia kislorodom (élektronno-mikroskopicheskoe i morfometricheskoe issledovanie).