Morphological transformation by early region human polyomavirus BK DNA of human fibroblasts with deletions in the short arm of one chromosome 11.
Human fibroblasts derived from four individuals with various deletions in the short arm of one chromosome 11 were susceptible to morphological transformation by early region BK virus DNA, whereas diploid human fibroblasts were not. This difference in susceptibility to transformation by early region BK virus DNA might be explained by a putative 'transformation suppressor' locus situated within the deleted region on the short arm of chromosome 11.
de Ronde
A
A
Department of Virology, University of Amsterdam, The Netherlands.
Mannens
M
M
Slater
R M
RM
Hoovers
J
J
Heyting
C
C
Bleeker-Wagemakers
E M
EM
Leschot
N J
NJ
van Strien
A
A
Sol
C J
CJ
ter Schegget
J
J
D001739:BK Virus / Q000235:genetics*; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D004279:DNA, Viral / Q000235:genetics*; D005347:Fibroblasts / Q000648:ultrastructure*; D006801:Humans; D011120:Polyomavirus / Q000235:genetics*; D013539:Simian virus 40 / Q000235:genetics
D004279:DNA, Viral