[Effect of human interferons on cAMP phosphodiesterase activity in a culture of human ovarian carcinoma cells (CaOv)].
Crude and purified human interferons of alpha type exerted 2 step inhibition of cAMP phosphodiesterase activity in CaOv cells: in 4 and 24 hours after cells treatment with interferon. The maximal inhibition was obtained in response to interferon doses 1200-2000 IU/ml. In contrast to natural interferons the human alpha 2 recombinant interferon (20-25000 IU/ml) did not inhibit the cAMP phosphodiesterase activity in CaOv cells.
Kalmakhelidze
K A
KA
Krispin
T I
TI
Itkes
A V
AV
Solov'eva
M F
MF
Balandin
I G
IG
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism*; D000242:Cyclic AMP / Q000096:biosynthesis; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D010051:Ovarian Neoplasms / Q000201:enzymology; D011994:Recombinant Proteins / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000201:enzymology*
D007370:Interferon Type I; D011994:Recombinant Proteins; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases
Vliianie chelovecheskikh interferonov na aktivnost' fosfodiésterazy cAMP v kul'ture kletok kartsinomy iaichnika cheloveka (CaOv).