Local anaesthetics modifying the dermal response of irradiation. An experimental study.
In a series of experiments in rabbits the dermal reaction, provoked by a single dose or intermittent doses of irradiation, was prevented or modified by topical or parenteral administration of local anaesthetics, compared to irradiated control animals. The topical application of a eutectic lidocaine/prilocaine cream, EMLA 5%, was found to be more effective than intravenously injected lidocaine (Xylocain 1%).
Ohlsén
L
L
Department of Plastic Surgery, University Hospital, Uppsala, Sweden.
Evers
H
H
Segerström
K
K
Hagelqvist
E
E
Graffman
S
S
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D006878:Hydroxides; D017665:Hydroxyl Radical; D008012:Lidocaine / Q000494:pharmacology; D000077442:Lidocaine, Prilocaine Drug Combination; D008297:Male; D011318:Prilocaine / Q000494:pharmacology; D011817:Rabbits; D011829:Radiation Dosage; D012867:Skin / Q000187:drug effects / Q000528:radiation effects*; D014945:Wound Healing
D000779:Anesthetics, Local; D004338:Drug Combinations; D006878:Hydroxides; D000077442:Lidocaine, Prilocaine Drug Combination; D011318:Prilocaine; D017665:Hydroxyl Radical; D008012:Lidocaine