Migration of neutrophils in experimental asthma.
Ovalbumin (OA) aerosol exposure caused an increase in phospholipase (PLase) activity in guinea pig lung membranes and in leukotriene B4 (LTB4) in lung lavages with subsequent neutrophil influx into lung lavages. These results suggest that activation of PLase after exposure to OA aerosol triggers an increase in LTB4 synthesis resulting in neutrophil influx into the airways.
Taki
F
F
Department of Internal Medicine and Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Japan.
Iwata
M
M
Sugiyama
S
S
Takagi
K
K
Satake
T
T
Ozawa
T
T
D000818:Animals; D001249:Asthma / Q000201:enzymology / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D002452:Cell Count; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D007975:Leukotriene B4 / Q000032:analysis; D008168:Lung / Q000032:analysis / Q000201:enzymology; D008566:Membranes / Q000201:enzymology; D009504:Neutrophils / Q000166:cytology / Q000473:pathology*; D010740:Phospholipases / Q000378:metabolism; D007507:Therapeutic Irrigation; D013997:Time Factors
D007975:Leukotriene B4; D010740:Phospholipases