[Respiratory sequellae after alternated chemotherapy and radiotherapy for small cell anaplastic cancer].
The authors analyze the respiratory sequelae in 19 patients with limited small cell lung carcinoma who survived for more than 30 months following an alternating chemo-radiotherapeutic combined regimen. The clinical tolerance measured with respiratory functional test is acceptable. In two patients an effort dyspnea is increased by evolutive, chronic obstructive bronchopneumopathy. Radiologic sequellae are constant and correlated with the volume of irradiation and cumulative etoposide doses. The role of a combined chemo-radiotherapeutic in pulmonary toxicity is discussed.
de Cremoux
H
H
Centre Hospitalier intercommunal, Créteil, France.
Baldeyrou
P
P
Martin
M
M
Ruffié
P
P
Arriagada
R
R
Le Chevalier
T
T
D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000528:radiation effects; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D008176:Lung Volume Measurements; D008297:Male; D012120:Respiration Disorders / Q000209:etiology*; D012129:Respiratory Function Tests
Sequelles respiratoires après chimiothérapie et radiothérapie alternées pour cancer anaplasique à petites cellules.