Agonist-like effects of the benzodiazepine receptor antagonist RO 15-1788.
The present study investigated the effects of the benzodiazepine receptor antagonist RO 15-1788 on the ability to resist sleep after 1 night of sleep deprivation. Repeated administrations of RO 15-1788 to 6 subjects significantly decreased their ability to resist sleep in comparison with repeated administration of 100 mg of vitamin C, and with a nontreatment condition. Most of the hypnotic effect occurred 80-100 min after drug ingestion. RO 15-1788 also significantly enhanced sleep stage 2 spindles activity. These results demonstrate that at certain dosages RO 15-1788 has agonist-like effects.
Lavie
P
P
Peled
R
R
Wollman
M
M
Zomer
J
J
Tzischinsky
O
O
D000328:Adult; D001143:Arousal / Q000187:drug effects*; D005442:Flumazenil / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects*; D012892:Sleep Deprivation; D012894:Sleep Stages / Q000187:drug effects*
D011963:Receptors, GABA-A; D005442:Flumazenil