title: Serum progesterone and norethisterone levels following injection of norethisterone enanthate in different sites and doses.
abstract: Serum progesterone (P) and norethisterone (NET) levels following injection of norethisterone enanthate (NETEN) were studied in 11 regularly menstruating women. In 6 subjects 200 mg NETEN was administered to the gluteal (IG) or deltoid (ID) region sequentially. The serum P levels remained anovulatory (less than 4 ng/mL) up to 12 weeks. Serum NET levels were similar whether injection was given IG or ID (paired t - test, NS). In 5 subjects given a 150-mg dose, serum P levels remained anovulatory up to 11 weeks. Serum NET levels declined faster than with the 200-mg dose, but the difference was not significant (Student's t - test, NS). Wide inter-subject variations were seen in both groups. NETEN therefore can effectively be administered in gluteal or deltoid regions. A lower dose of 150 mg may have contraceptive potential on an 8-week schedule.
authors.affiliation: Institute for Research in Reproduction, Bombay, India.
authors.forename: J V
authors.initials: JV
authors.lastname: Joshi
authors.forename: K T
authors.initials: KT
authors.lastname: Hazari
authors.forename: R S
authors.initials: RS
authors.lastname: Shah
authors.forename: U C
authors.initials: UC
authors.lastname: Chadha
authors.forename: S
authors.initials: S
authors.lastname: Chitlange
authors.forename: J S
authors.initials: JS
authors.lastname: Gokral
authors.forename: S G
authors.initials: SG
authors.lastname: Arolkar
mesh_terms: D000328:Adult; D000858:Anovulation / Q000139:chemically induced; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008598:Menstruation; D009640:Norethindrone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood* / Q000494:pharmacology; D011374:Progesterone / Q000097:blood*
chemical_list: D003280:Contraceptives, Oral, Synthetic; D011374:Progesterone; C024319:norethindrone enanthate; D009640:Norethindrone