title: In vitro absorption of some chlorinated paraffins through human skin.
abstract: The in vitro absorption of chlorinated paraffins, Cereclor S52 and Cereclor 56L (present in a cutting fluid), has been measured through human skin. During 56 h continuous skin contact no Cereclor S52 was detected to have been absorbed and only a very slow rate of Cereclor 56L absorption (mean rate, 0.04 micrograms/cm/h) was measured. This rate was only apparent after more than 7 h continuous skin contact. These chlorinated paraffins were very poorly absorbed through human skin and human dermal exposure should not cause significant systemic levels.
authors.affiliation: Biochemical Toxicology Section, ICI Central Toxicology Laboratory, Nr Macclesfield, Cheshire, UK.
authors.forename: R C
authors.initials: RC
authors.lastname: Scott
mesh_terms: D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000493:pharmacokinetics*; D010232:Paraffin / Q000493:pharmacokinetics*; D014677:Pharmaceutical Vehicles; D012869:Skin Absorption
chemical_list: D006843:Hydrocarbons, Chlorinated; D014677:Pharmaceutical Vehicles; D010232:Paraffin