Decreased density of peripheral benzodiazepine binding sites on platelets of currently drinking, but not abstinent alcoholics.
Using the isoquinoline carboxamide derivative, PK 11195 as selective ligand, the binding properties of peripheral benzodiazepine binding sites were compared on platelets of alcoholics and non-alcoholic, healthy controls. When compared to controls, alcoholics during prolonged ethanol consumption show a significant reduction in the density of platelet [3H]PK 11195 binding sites. However, following abstention from alcohol, the density of these sites is similar to controls. These data suggest that a reduction in the density of peripheral benzodiazepine binding sites on platelets may be a biochemical index of prolonged ethanol use and indicate a possible role for these sites in mediating the chronic effects of alcohol.
Suranyi-Cadotte
B
B
Douglas Hospital Research Centre, Verdun, Québec, Canada.
Lafaille
F
F
Dongier
M
M
Dumas
M
M
Quirion
R
R
D000328:Adult; D000428:Alcohol Drinking; D000437:Alcoholism / Q000097:blood*; D001665:Binding Sites; D001792:Blood Platelets / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007546:Isoquinolines; D008297:Male; D008875:Middle Aged; D011963:Receptors, GABA-A / Q000097:blood / Q000187:drug effects*; D013695:Temperance
D007546:Isoquinolines; D011963:Receptors, GABA-A; C037850:PK 11195