Development of bladder tumour containing HPV type 11 DNA after renal transplantation.
We report a case of bladder cancer developing in a patient after renal transplantation in whom it was possible to demonstrate DNA evidence for infection of the tumour with HPV Type 11. The significance of the observation is discussed in relation to the hypothesis that immunosurveillance can control the development of malignancy.
Querci della Rovere
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G
Renal Transplant Unit, Cromwell Hospital, London.
Oliver
R T
RT
McCance
D J
DJ
Castro
J E
JE
D000328:Adult; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D016030:Kidney Transplantation; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae; D011183:Postoperative Complications / Q000209:etiology*; D014412:Tumor Virus Infections / Q000209:etiology*; D001749:Urinary Bladder Neoplasms / Q000209:etiology* / Q000235:genetics
D004279:DNA, Viral