Azithromycin, a macrolide antibiotic with potent activity against Toxoplasma gondii.
Doses of 200 mg of azithromycin per kg (body weight) administered by the oral route daily for 10 days completely protected mice against death caused by intraperitoneal infection with Toxoplasma gondii. The same treatment regimen also protected 80% of mice infected intracerebrally, which suggests that azithromycin attains active concentrations in the inflamed central nervous system.
Araujo
F G
FG
Research Institute, Palo Alto Medical Foundation, California 94301.
Guptill
D R
DR
Remington
J S
JS
D000818:Animals; D017963:Azithromycin; D001927:Brain Diseases / Q000188:drug therapy; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051379:Mice; D010538:Peritonitis / Q000188:drug therapy; D014124:Toxoplasmosis, Animal / Q000188:drug therapy*
D004917:Erythromycin; D017963:Azithromycin