Light-induced changes in the content of inositol phosphates in squid (Loligo pealei) retina.
Illumination induced an increase in inositol polyphosphates, inositol 1,4-bisphosphate and inositol 1,4,5-trisphosphate, in the photoreceptors of the squid, Loligo pealei. There was a concomitant decrease in phosphatidylinositol 4,5-bisphosphate, but no light-induced change in any other phosphoinositide. None of these stimulus-induced changes were altered by treatment in vivo with pertussis toxin, which ADP-ribosylated a Mr-39000-peptide. These findings support the hypothesis that inositol 1,4,5-trisphosphate participates as either a messenger or a modulator in transduction in invertebrate photoreceptors.
Brown
J E
JE
Department of Ophthalmology, Washington University School of Medicine, St. Louis, MO 63110.
Watkins
D C
DC
Malbon
C C
CC
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D049832:Decapodiformes / Q000378:metabolism*; D007295:Inositol Phosphates / Q000378:metabolism*; D008027:Light; D037342:Pertussis Toxin; D010716:Phosphatidylinositols / Q000378:metabolism; D012160:Retina / Q000187:drug effects / Q000378:metabolism*; D013403:Sugar Phosphates / Q000378:metabolism*; D010566:Virulence Factors, Bordetella / Q000494:pharmacology
D007295:Inositol Phosphates; D010716:Phosphatidylinositols; D013403:Sugar Phosphates; D010566:Virulence Factors, Bordetella; D037342:Pertussis Toxin