title: Cytomegalovirus infection in HIV-1-infected individuals.
abstract: Urinary excretion of Cytomegalovirus and the presence of serum antibodies against CMV were examined in 79 HIV-1-infected patients at different stages of the disease, as well as in 27 heterosexual and 52 male homosexual controls and correlated to clinical and laboratory results. HIV-1-infected and healthy individuals differed significantly with regard to cutaneous delayed type reactions, absolute numbers of CD4+ cells and CD4+/CD8+ ratios. IgG antibodies against CMV were found in 87% of homosexual and in 52% of heterosexual controls, and in all HIV-1-infected homosexuals. CMV excretion in the urine was exclusively found in HIV-1-infected individuals where the incidence correlated with the CDC-defined disease stage (stage II: 6%, stage III/IV A: 22%, stage IV B/C: 55%). HIV-1-infected patients excreting CMV in the urine also exhibited distinctly decreased numbers of CD4+ cells and significantly decreased CD4+/CD8+ ratios compared to those without CMV viruria.
authors.affiliation: Virologische Abteilung, Staatliches Medizinaluntersuchungsamt, Hannover.
authors.forename: U
authors.initials: U
authors.lastname: Süttmann
authors.forename: H
authors.initials: H
authors.lastname: Willers
authors.forename: R
authors.initials: R
authors.lastname: Gerdelmann
authors.forename: W
authors.initials: W
authors.lastname: Höpken
authors.forename: I
authors.initials: I
authors.lastname: Schedel
authors.forename: H
authors.initials: H
authors.lastname: Deicher
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology; D000914:Antibodies, Viral / Q000032:analysis; D003586:Cytomegalovirus Infections / Q000209:etiology* / Q000276:immunology; D005260:Female; D006716:Homosexuality; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008297:Male; D012882:Skin Tests; D013601:T-Lymphocytes / Q000145:classification
chemical_list: D000914:Antibodies, Viral