title: Post-transfusion purpura and isoimmune neonatal thrombocytopenia in the same family.
abstract: Post-transfusion purpura and isoimmune neonatal thrombocytopenia are rare and unusual syndromes leading to severe thrombocytopenia. In both disorders the PLA1 platelet antigen is involved in the pathogenesis. A 41-year-old woman with an obstetrical history of isoimmune neonatal thrombocytopenia in two of her children developed post-transfusion purpura following a transfusion of packed red blood cells. Despite the apparent link in these two disorders associated with the PLA1 platelet antigen, this is the first reported case of post-transfusion purpura and isoimmune neonatal thrombocytopenia occurring in the same family.
authors.affiliation: Department of Medicine, Letterman Army Medical Center Presidio, San Francisco.
authors.forename: E
authors.initials: E
authors.lastname: Cobos
authors.forename: D R
authors.initials: DR
authors.lastname: Gandara
authors.forename: L J
authors.initials: LJ
authors.lastname: Geier
authors.forename: S
authors.initials: S
authors.lastname: Kirmani
mesh_terms: D000328:Adult; D000941:Antigens / Q000032:analysis; D001792:Blood Platelets / Q000276:immunology; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000276:immunology; D011693:Purpura / Q000150:complications* / Q000276:immunology; D013921:Thrombocytopenia / Q000150:complications* / Q000276:immunology
chemical_list: D000941:Antigens; D007518:Isoantibodies