title: The role of iron in the initiation of lipid peroxidation.
abstract: Iron is required for the initiation of lipid peroxidation. Evidence is presented that lipid peroxidation requires both Fe3+ and Fe2+, perhaps with oxygen to form a Fe3+-dioxygen-Fe2+ complex. Other mechanisms of initiation, mostly involving the iron-catalyzed formation of hydroxyl radical, are described and discussed from both theoretical and experimental view points.
authors.affiliation: Department of Biochemistry, Michigan State University, East Lansing 48824-1319.
authors.forename: G
authors.initials: G
authors.lastname: Minotti
authors.forename: S D
authors.initials: SD
authors.lastname: Aust
mesh_terms: D005609:Free Radicals; D006878:Hydroxides; D017665:Hydroxyl Radical; D007501:Iron / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D010544:Peroxidases / Q000378:metabolism*
chemical_list: D005609:Free Radicals; D006878:Hydroxides; D008054:Lipid Peroxides; D017665:Hydroxyl Radical; D007501:Iron; D010544:Peroxidases