Cyproheptadine inhibits the corticotropin releasing hormone (CRH)--induced hormone release in normal subjects.
To further elucidate the inhibitory action of cyproheptadine on ACTH release, we studied the influence of cyproheptadine (0.1 mg/kg body weight) on the corticotropin releasing hormone (CRH)--induced hormone release in normal subjects. On two occasions six healthy volunteers underwent a CRH-test (0.1 mg hCRH as bolus i.v.) combined with an infusion of either cyproheptadine or saline starting 30 min prior to the CRH injection. Cyproheptadine led to a significant suppression of the plasma ACTH (p less than 0.05) and serum cortisol (p less than 0.005) response to CRH compared to placebo suggesting a direct inhibitory action of cyproheptadine at the pituitary level.
Allolio
B
B
Medizinische Universitätsklinik II, Köln, Germany.
Schulte
H M
HM
Deuss
U
U
Winkelmann
W
W
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000328:Adult; D003346:Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism
D003533:Cyproheptadine; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone