Genes of nuclear encoded mitochondrial proteins: evidence for a variant of the 3' splice-site consensus sequence.
The introns of animal nuclear genes and of viral genes encoding protein possess at their 3' splice-site the consensus sequence (CT)11NTCAG (Mount, S.M. (1982) Nucl. Acids Res. 10, 459-472; Green, M.R. (1986) Ann. Rev. Genet. 20, 671-708). However, the total 39 introns of the 5 imported mitochondrial proteins of higher eucaryotes whose gene structure has been determined to date show a predominance of 44% for base T at position -4. Apparently, a variant consensus sequence, i.e. (CT)11TTCAG, characterizes the genes of nuclear encoded mitochondrial proteins.
Juretić
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N
Biochemisches Institut, Universität Zürich, Switzerland.
Jaussi
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R
Mattes
U
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Christen
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P
D000624:5-Aminolevulinate Synthetase / Q000235:genetics; D001219:Aspartate Aminotransferases / Q000235:genetics; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / Q000235:genetics; D003574:Cytochrome c Group / Q000235:genetics; D005796:Genes; D008928:Mitochondria / Q000502:physiology*; D012326:RNA Splicing; D012045:Regulatory Sequences, Nucleic Acid
D003574:Cytochrome c Group; D000624:5-Aminolevulinate Synthetase; D001219:Aspartate Aminotransferases; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)