Receptor-phosphoinositidase C coupling. Multiple G-proteins?
Recent evidence has suggested that receptor-mediated phosphoinositide turnover, like that of the adenylate cyclase cAMP pathway, is regulated by guanine nucleotides. It is likely that one or more guanine nucleotide-binding proteins (G-proteins) couple calcium-mobilizing receptors to the activation of phosphoinositidase C. Recent studies utilizing various bacterial toxins have strongly suggested the presence of multiple G-proteins in the regulation of receptor-phosphoinositidase C coupling in a variety of cell types.
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Parke-Davis Research Unit, Addenbrookes Hospital Site, Cambridge, England.
Hughes
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D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology; D004789:Enzyme Activation; D019204:GTP-Binding Proteins / Q000145:classification / Q000502:physiology*; D006801:Humans; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000502:physiology; D016283:Proto-Oncogene Proteins p21(ras); D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology*
D001427:Bacterial Toxins; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D010727:Phosphoric Diester Hydrolases; C021491:glycerophosphoinositol glycerophosphodiesterase; D019204:GTP-Binding Proteins; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras); D000262:Adenylyl Cyclases