Peptide growth factors are multifunctional.
The actions of many peptide growth factors include both stimulation and inhibition of cell proliferation, as well as effects unrelated to the control of cell growth. One peptide can have both stimulatory and inhibitory activity in a single cell, depending on the context of the other signal molecules present.
Sporn
M B
MB
Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892.
Roberts
A B
AB
D000818:Animals; D002455:Cell Division; D004815:Epidermal Growth Factor / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000502:physiology; D006133:Growth Substances / Q000502:physiology*; D007378:Interleukins / Q000502:physiology; D010455:Peptides / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology; D015291:Transforming Growth Factors; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D006133:Growth Substances; D007378:Interleukins; D010455:Peptides; D011956:Receptors, Cell Surface; D014409:Tumor Necrosis Factor-alpha; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D015291:Transforming Growth Factors