title: HIV-1 production from infected peripheral blood T cells after HTLV-I induced mitogenic stimulation.
abstract: The human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type I (HTLV-I) are two distinct human retroviruses that infect T cells. Recent epidemiologic studies have identified a cohort of individuals that are coinfected with both viruses. It is reported here that human peripheral blood leukocytes infected with HIV-1 in vitro can be induced to produce large quantities of HIV-1 after mitogenic stimulation by noninfectious HTLV-I virions. It is also shown that HTLV-I virions may exert this effect prior to, immediately following, or well after the cells are infected with HIV-1. These results provide further impetus for epidemiologic studies of dually infected individuals to determine whether HTLV-I may act as a cofactor for acquired immunodeficiency syndrome (AIDS).
authors.affiliation: Division of Hematology-Oncology, UCLA School of Medicine 90024.
authors.forename: J A
authors.initials: JA
authors.lastname: Zack
authors.forename: A J
authors.initials: AJ
authors.lastname: Cann
authors.forename: J P
authors.initials: JP
authors.lastname: Lugo
authors.forename: I S
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology; D017977:Deltaretrovirus / Q000276:immunology*; D006678:HIV / Q000254:growth & development* / Q000302:isolation & purification; D006801:Humans; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology / Q000382:microbiology*; D014775:Virus Activation