A BrdU-enhanceable fragile site or viral modification site at 11q23.1 in lymphoblastoid cultures.
Chromosomes prepared from EBV-transformed lymphoblastoid cell lines show an achromatic gap or fragile site-like lesion at 11q23.1. The low spontaneous expression of this lesion is greatly enhanced by BrdU and n-butyric acid. The lesion was expressed homozygously in all 16 cell lines examined. It is suggested that the lesion is a viral chromosome modification site.
Sutherland
G R
GR
Cytogenetics Unit, Adelaide Children's Hospital, Australia.
Baker
E
E
Callen
D F
DF
D001973:Bromodeoxyuridine / Q000494:pharmacology; D002461:Cell Line, Transformed; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002880:Chromosomes, Human, Pair 11; D004854:Herpesvirus 4, Human; D006801:Humans; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D001973:Bromodeoxyuridine; D013755:Tetradecanoylphorbol Acetate