title: Correlation of ovarian follicle size and the urinary excretion of oestrone glucuronide, luteinizing hormone and pregnanediol glucuronide in spontaneous cycles.
abstract: Ovarian follicular development was investigated in 17 apparently normal women in whom ovulation was dated using real-time ultrasonography. Ultrasonic determination of follicular growth was performed on a daily basis with a real-time sector scanner, and correlated with daily concentrations of oestrone-3-glucuronide (E1-3-G), luteinizing hormone (LH) and the ratio of E1-3-G to pregnanediol-3 alpha-glucuronide (Pd-3 alpha-G) in early morning urine. The main results from ultrasonography showed that all patients except one developed follicles greater than 1.8 cm, with a mean growth rate of 0.18 cm/day. There was a statistically significant correlation between the mean follicular diameter and the mean concentrations of urinary E1-3-G (r = 0.95, P less than 0.001) and ratio of E1-3-G to Pd-3 alpha-G (r = 0.97, P less than 0.001) during the 8 days prior to ovulation.
authors.affiliation: Department of Obstetrics and Gynaecology, University College Hospital, Ibadan, Nigeria.
authors.forename: A O
authors.initials: AO
authors.lastname: Adekunle
authors.forename: W P
authors.initials: WP
authors.lastname: Collins
authors.forename: M I
authors.initials: MI
authors.lastname: Whitehead
mesh_terms: D000328:Adult; D004970:Estrone / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000652:urine*; D008597:Menstrual Cycle; D006080:Ovarian Follicle / Q000033:anatomy & histology* / Q000502:physiology; D010060:Ovulation; D011276:Pregnanediol / Q000031:analogs & derivatives* / Q000652:urine; D014463:Ultrasonography
chemical_list: C022270:pregnanediol-3 alpha-glucuronide; C015856:estrone-3-glucuronide; D004970:Estrone; D007986:Luteinizing Hormone; D011276:Pregnanediol