Phospholipid and fatty acid changes produced by cholecalciferol on intestinal mitochondrial membranes.
Cholecalciferol administration to vitamin D-deficient chicks produces, 24 h after treatment, a specific increase of the phosphatidylcholine content in the intestinal mitochondrial inner membrane plus matrix fraction without changes in its proportion in the outer membrane. The ratio of unsaturated/saturated fatty acids in the outer membrane phosphatidylcholine was increased by that treatment. The inner membrane plus matrix presents a decrease of 16:1 in phosphatidylethanolamine and 18:0 in the phosphatidylcholine fraction. Cardiolipin shows the largest change in the ratio of unsaturated/saturated fatty acids predominantly by an increase in the linoleic acid. The present data suggest that phosphatidylcholine and fatty acids modifications in both mitochondrial subfractions caused by vitamin D3 might have some role in the intestinal mitochondrial Ca transport.
Tolosa de Talamoni
N
N
Cátedra de Química Biológica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, República Argentina.
Hauen de Bronia
D
D
Pereira
R
R
Moreno
J
J
Cañas
F
F
D000818:Animals; D002645:Chickens; D002762:Cholecalciferol / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000378:metabolism*
D005227:Fatty Acids; D008563:Membrane Lipids; D010743:Phospholipids; D002762:Cholecalciferol