[The role of irreparable DNA damage in initiating chromosomal mutagenesis in Chinese hamster cells irradiated with gamma and secondary proton radiation with an energy of 70 GeV].
The study on the kinetics of DNA injury repair in Chinese hamster cells exposed to gamma and secondary proton radiation (70 GeV) has demonstrated the absence of distinctions in the kinetics of repair of rapidly repaired damages, a decreased rate of repair of slowly repaired lesions, and an increased residual irreparable damage induced by secondary radiation that reliably correlates with the RBE value estimated by the cytogenetic effect.
Zaichkina
S I
SI
Livanova
I A
IA
Akhmadieva
A Kh
AKh
Antipov
A V
AV
Ganassi
E E
EE
D000818:Animals; D002478:Cells, Cultured; D002875:Chromosomes / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D004249:DNA Damage; D004260:DNA Repair / Q000528:radiation effects*; D004277:DNA, Single-Stranded / Q000528:radiation effects*; D005720:Gamma Rays; D007700:Kinetics; D009154:Mutation; D011522:Protons; D012062:Relative Biological Effectiveness; D013997:Time Factors
D004277:DNA, Single-Stranded; D011522:Protons
O roli nerepariruemogo povrezhdeniia DNK v initsiatsii khromosomnogo mutageneza v kletkakh kitaĭskogo khomiachka, obluchennykh gamma- i vtorichnym izlucheniem ot protonov s énergieĭ 70 GéV.