Materials with opiate receptor binding activity in bovine testis and ovine pancreas.
Two groups of opiate-like materials, one with a molecular weight equal to or greater than 5000 daltons and another with a molecular weight smaller than 5000 daltons as judged by gel filtration on Sephadex G-25, were detected in bovine testes. The existence of opiate-like materials with a molecular weight smaller than 5000 daltons was demonstrated in ovine pancreas. The pancreatic fraction most strongly adsorbed on CM-cellulose possessed the highest opiate receptor binding activity. Bovine testis contained corticotropin-like material(s) which stimulated corticosterone production by isolated rat adrenal cells.
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Department of Biochemistry, Faculty of Medicine, Chinese University of Hong Kong, Shatin.
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D000818:Animals; D001923:Brain Chemistry; D002417:Cattle; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D004723:Endorphins / Q000032:analysis*; D004743:Enkephalin, Leucine / Q000032:analysis; D008297:Male; D008970:Molecular Weight; D010179:Pancreas / Q000032:analysis*; D051381:Rats; D011957:Receptors, Opioid / Q000378:metabolism*; D012756:Sheep; D013737:Testis / Q000032:analysis*
D004723:Endorphins; D011957:Receptors, Opioid; D004743:Enkephalin, Leucine