[Changes in the microviscosity of the plasma membrane and sensitivity to PGE1 of platelets stored at 22 and 4 degrees C].
Effect of platelet storage within 1-3 days on the cell membranes microviscosity, studied by means of a spin probe, and their sensitivity to PGEI, inhibitor of ADP aggregation, were studied. The highest values of fluidity and PGEI sensitivity exhibited plasmatic membranes of platelets stored at 22 degrees; lower values were found in the membranes stored at 4 degrees as compared with native fresh platelets. The data obtained suggest the dissimilar character of alterations in structure and functions of platelet plasmatic membrane during storage at 22 degrees and 4 degrees.
Kuznetsov
V A
VA
Melkonian
S G
SG
Lisovskaia
I L
IL
Volkova
R I
RI
D000527:Alprostadil / Q000494:pharmacology*; D001792:Blood Platelets / Q000032:analysis / Q000187:drug effects / Q000502:physiology*; D001793:Blood Preservation; D001809:Blood Viscosity; D002462:Cell Membrane / Q000032:analysis / Q000187:drug effects / Q000502:physiology; D003080:Cold Temperature; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D010974:Platelet Aggregation
D000527:Alprostadil
Izmenenie mikroviazkosti plazmaticheskoĭ membrany i chuvstvitel'nosti k PGE1 trombotsitov, khraniashchikhsia pri 22 i 4 gradusakh C.