[Inhibitory effect of various analogs of nucleoside-5'-triphosphates on DNA synthesis catalyzed by DNA polymerase from herpes simplex virus type I].
The effect of nucleoside-5-triphosphates analogues on the DNA polymerase of herpes simplex virus (HSV) has been investigated. Evidence is obtained that 3-amino-2,3-dideoxythymidine triphosphate selectively inhibits the DNA synthesis, catalyzed by HSV DNA polymerase. 3-amino-2,3-dideoxythymidine exhibits antiherpetic effect in single cells cultures. It may be phosphorylated by cellular thymidine kinase. The nuclei of Vero cells infected by HSV are an adequate system for antiherpetic compounds screening.
Kilesso
T Iu
TIu
Shobukhov
V M
VM
Papchikhin
A V
AV
Galegov
G A
GA
D000818:Animals; D000998:Antiviral Agents; D004279:DNA, Viral / Q000096:biosynthesis* / Q000187:drug effects; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D019384:Nucleic Acid Synthesis Inhibitors; D009711:Nucleotides / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects / Q000201:enzymology*; D013329:Structure-Activity Relationship; D014709:Vero Cells
D000998:Antiviral Agents; D004279:DNA, Viral; D019384:Nucleic Acid Synthesis Inhibitors; D009711:Nucleotides; D004259:DNA-Directed DNA Polymerase
Ingibiruiushchee deĭstvie nekotorykh analogov nukleozid-5'-trifosfatov na sintez DNK, kataliziruemyĭ DNK-polimerazoĭ virusa gerpesa prostogo I tipa.