Combinations of rifampin or rifabutine plus ethambutol against Mycobacterium avium complex. Bactericidal synergistic, and bacteriostatic additive or synergistic effects.
Ethambutol, when combined with rifampin or rifabutine (ansamycin, LM427), produced an additive inhibitory effect against most of the tested M avium complex strains (12 of 16 with rifampin, 13 of 16 with rifabutine). The inhibitory effect was synergistic for the remaining 4 of 16 and 3 of 16 strains. This relationship reduced the minimal inhibitory concentrations for each drug in combination. In addition, the minimal bactericidal concentrations of all 3 drugs were reduced because of synergistic bactericidal activity in 6 of 6 strains tested.
Heifets
L B
LB
National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
Iseman
M D
MD
Lindholm-Levy
P J
PJ
D004347:Drug Interactions; D004357:Drug Synergism; D004977:Ethambutol / Q000494:pharmacology*; D009162:Mycobacterium avium / Q000187:drug effects*; D017828:Rifabutin; D012293:Rifampin / Q000494:pharmacology*; D012294:Rifamycins / Q000494:pharmacology*
D012294:Rifamycins; D017828:Rifabutin; D004977:Ethambutol; D012293:Rifampin