Identification of an LtB4-protein complex as evidence of endothelial cell cytotoxic activity (ECA) in progressive systemic sclerosis (PSS).
A low molecular weight LtB4-carrier complex has been identified as endothelial cytotoxic activity (ECA) in progressive systemic sclerosis (PSS) patients' sera. ECA is thought to play a key role in the initiation of obliterative vasculopathy, a basic tissue lesion of this disease.
Deicher
H R
HR
Abt. Immunologie und Transfusionsmedizin, Medizinische Hochschule Hannover, FRG.
Drenk
F
F
Hoffman
G
G
D002352:Carrier Proteins / Q000097:blood*; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D007975:Leukotriene B4 / Q000097:blood*; D008970:Molecular Weight; D012595:Scleroderma, Systemic / Q000097:blood / Q000473:pathology*
D002352:Carrier Proteins; D007975:Leukotriene B4