title: The role of adenine nucleotide translocators in regulation of oxidative phosphorylation in heart mitochondria.
abstract: The regulative role of adenine nucleotide translocators (ANTs) in oxidative phosphorylation has been estimated by the titration of respiration of isolated rabbit heart mitochondria with carboxyatractyloside in the presence of a non-rate limiting creatine phosphokinase ADP-regenerating system. It has been established that the respiration rate is not controlled by ANTs in the two extreme states, state 3 and state 4. On the other hand, at an intermediate respiration rate (30-70% of the state 3 respiration, which roughly corresponds to that under physiological conditions) the ANT control coefficient had a value of 0.62-0.75. Thus, ANTs seem to play a key role in the regulation of oxidative phosphorylation.
authors.affiliation: Research Institute for Technology and Safety of Drugs, Moscow Region, USSR.
authors.forename: B
authors.initials: B
authors.lastname: Kholodenko
authors.forename: V
authors.initials: V
authors.lastname: Zilinskiene
authors.forename: V
authors.initials: V
authors.lastname: Borutaite
authors.forename: L
authors.initials: L
authors.lastname: Ivanoviene
authors.forename: A
authors.initials: A
authors.lastname: Toleikis
authors.forename: A
authors.initials: A
authors.lastname: Praskevicius
mesh_terms: D000818:Animals; D001278:Atractyloside / Q000031:analogs & derivatives; D008929:Mitochondria, Heart / Q000502:physiology*; D000226:Mitochondrial ADP, ATP Translocases / Q000502:physiology*; D009713:Nucleotidyltransferases / Q000502:physiology*; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D010725:Phosphocreatine / Q000378:metabolism; D011817:Rabbits
chemical_list: D010725:Phosphocreatine; D001278:Atractyloside; D000226:Mitochondrial ADP, ATP Translocases; D009713:Nucleotidyltransferases; C003853:carboxyatractyloside