Biology and pharmacology of recombinant human interleukin-1 beta-induced rat ear inflammation.
A single, 10 ng intradermal injection of human recombinant interleukin-1 beta (rIL-1 beta) into rat ears produced acute inflammation. Tissue wet weight (edema) and total myeloperoxidase activity (PMN accumulation), peaked at 3 hours and returned to base line at 3 days. Given orally, 1 hour prior to rIL-1 beta injection, cyproheptadine, dexamethasone, conventional NSAID's, or mixed cyclooxygenase/lipoxygenase inhibitors were potent antagonists of edema and moderate antagonists of PMN accumulation. In addition, the putative DMARD's, auranofin, dapsone, and levamisole were effective inhibitors of rIL-1 beta induced inflammation.
De Young
L M
LM
Syntex Research, Palo Alto, CA 94304.
Spires
D A
DA
Kheifets
J
J
Terrell
T G
TG
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001310:Auranofin / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced* / Q000201:enzymology / Q000517:prevention & control; D007375:Interleukin-1 / Q000494:pharmacology*; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007375:Interleukin-1; D001310:Auranofin; D003907:Dexamethasone; D009195:Peroxidase