MXT mammary tumor treated by low dose chemotherapy. A 31P-NMR and 1H-MRI study.
The effects induced by a low dose cyclophosphamide treatment (CPA) along with an attempt of estradiol-17-beta (E2) cell recruitment, on the bioenergetics and the phosphomonoesters/phosphodiesters (PME/PDE) ratio in the transplantable MXT mouse mammary tumor have been studied by 31P-NMR spectroscopy in vivo. Our results show that neither ovariectomy (OO) nor the additional low dose E2 + CPA treatment significantly decreased tumor growth, whilst E2 + CPA treatment induced significant modifications compared to values recorded in tumors grafted on intact or ovariectomized animals, of all peak height ratios but PME/PDE, which further remained at a constant value during tumor growth.
Scheiber
C
C
Service de Radiothérapie et de Médecine Nucléaire, Institut J. Bordet, Centre des Tumerurs de l'Université Libre de Bruxelles, Belgium.
Kiss
R
R
De Launoit
Y
Y
Frühling
J
J
D000818:Animals; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004958:Estradiol / Q000008:administration & dosage; D005260:Female; D008279:Magnetic Resonance Imaging; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy
D004958:Estradiol; D003520:Cyclophosphamide