Structure of a novel human granulocyte peptide with anti-ACTH activity.
We report the purification, structure and biological properties of a peptide of novel sequence from human granulocytes that inhibits ACTH stimulated synthesis of corticosterone in rat adrenal cell suspensions. The peptide HP-4 is homologous to a previously described human granulocyte peptide HP-1 that has no anti-ACTH activity.
Singh
A
A
Royal Victoria Hospital, Department of Medicine, Montreal, Quebec, Canada.
Bateman
A
A
Zhu
Q Z
QZ
Shimasaki
S
S
Esch
F
F
Solomon
S
S
D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000037:antagonists & inhibitors*; D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D006098:Granulocytes / Q000032:analysis*; D006131:Growth Inhibitors / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000302:isolation & purification* / Q000502:physiology; D051381:Rats; D013329:Structure-Activity Relationship
D006131:Growth Inhibitors; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C054598:corticostatin; D000324:Adrenocorticotropic Hormone