Phenytoin induced fatal hepatic injury.
A 61 year old female developed fatal hepatic failure after phenytoin administration. A typical multisystem clinical pattern precedes the manifestations of hepatic injury. The hematologic, biochemical and pathologic features indicate a mixed hepatocellular damage due to drug hypersensitivity. In a patient receiving phenytoin who presents a viral-like illness, early recognition and discontinuation of the drug are mandatory.
Carro
J A
JA
Senior
J
J
Rubio
C E
CE
Torres
E A
EA
D001932:Brain Neoplasms / Q000601:surgery; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D006801:Humans; D008579:Meningioma / Q000601:surgery; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects*; D011183:Postoperative Complications / Q000517:prevention & control; D012640:Seizures / Q000517:prevention & control
D010672:Phenytoin