Are increases in GABAB receptors consistent findings following chronic antidepressant administration?
Desmethylimipramine and zimelidine (10 mg/kg) were administered to rats once daily for 21 days. Chronic desmethylimipramine significantly reduced the number of 5HT2 binding sites in the frontal cortex but not hippocampus while chronic zimelidine did not affect 5HT2 binding in either brain region. The number and affinity of GABAB binding sites in the frontal cortex were unaltered by either drug.
Cross
J A
JA
Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London, U.K.
Horton
R W
RW
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D003891:Desipramine / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects
D000928:Antidepressive Agents; D011963:Receptors, GABA-A; D011985:Receptors, Serotonin; D003891:Desipramine