New delta-receptor antagonists.
A new delta-selective opiate antagonist has been synthesised in which the two glycine residues of diallyl leucine enkephalin have been replaced by 4-aminobenzoic acid. The compound has a different conformation to that of ICI 174,864 (N,N-diallyl-Tyr-Aib-Aib-Phe-Leu).
Thornber
C W
CW
Department of Chemistry, ICI Pharmaceuticals Division, Alderley Park, Cheshire, UK.
Shaw
J S
JS
Miller
L
L
Hayward
C F
CF
Morley
J S
JS
Timms
D
D
Wilkinson
A
A
D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009292:Narcotic Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects* / Q000378:metabolism; D017465:Receptors, Opioid, delta; D014649:Vas Deferens / Q000187:drug effects / Q000502:physiology
D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta