[Animal experiment studies of the diagnosis and therapy of chymopapain-induced spinal complications].
Short and long-term effects of chymopapain on nervous transmission were studied in rats. The drug was injected into the lumbar spinal canal. Action potentials evoked by electrical stimulation of the sciatic nerve were recorded at the dorsal root entry zone of the lumbar cord. One group of rats was pre-treated with dexamethasone. Chymopapain prolongs impulse latency compared to that of control rats treated with isotonic saline. The effect is dose dependent and can last for several weeks. Rats pre-treated with dexamethasone showed milder impairment of nervous transmission after chymopapain injection compared to the rats treated only with papain.
Wehling
P
P
Orthopädische Klinik und Poliklinik der Universität Düsseldorf.
Pak
M A
MA
Schulitz
K P
KP
D000818:Animals; D002917:Chymopapain / Q000633:toxicity*; D003907:Dexamethasone / Q000008:administration & dosage; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D008159:Lumbar Vertebrae / Q000187:drug effects*; D008297:Male; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects*; D013126:Spinal Nerve Roots / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D003907:Dexamethasone; D002917:Chymopapain
Tierexperimentelle Untersuchungen zur Diagnostik und Therapie chymopapaininduzierter spinaler Komplikationen.