title: Platelet membrane and calcium control abnormalities in essential hypertension.
abstract: The mechanisms whereby intracellular calcium concentration is controlled are briefly reviewed. With the current knowledge of both calcium homeostasis and the function and properties of cellular Ca2+-target proteins/signal transduction systems, a dysfunction of cellular calcium metabolism is considered in relation to the pathogenesis of hypertension. Although the enhanced peripheral vascular resistance characteristic of hypertension is ultimately a function of Ca2+ availability for smooth muscle cell contraction, the platelet possesses many parallel biochemical and physiologic properties. Therefore, we have utilized the platelet as the cell model for investigating the role of Ca2+ in hypertension disorders. An overview of Ca2+-linked platelet processes altered in essential hypertension is presented, and an attempt is made to integrate these multiple aberrations in a fundamental membrane lesion.
authors.affiliation: Department of Research, University Hospital, Basel, Switzerland.
authors.forename: F R
authors.initials: FR
authors.lastname: Bühler
authors.forename: T J
authors.initials: TJ
authors.lastname: Resink
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism* / Q000648:ultrastructure; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D007424:Intracellular Fluid / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism
chemical_list: D002147:Calmodulin; D010716:Phosphatidylinositols; D000262:Adenylyl Cyclases; D002118:Calcium