Immunization against the polyoma tumor-specific transplantation antigen (TSTA) with polyoma T-antigens.
The relationship between the polyoma virus tumor-specific transplantation antigen (TSTA) and 2 of the virus proteins coded from the early region of polyomavirus was investigated. Mice were immunized with small T antigen and a truncated mutant of middle T antigen, both purified from genetically engineered Escherichia coli. The 2 proteins induced protective immunity against polyomavirus-induced tumors, but not against non-polyoma tumors, indicating that one or more of the polyoma T antigens are directly involved in a TSTA function.
Ramqvist
T
T
Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
Pallas
D O
DO
DeAnda
J
J
Ahrlund-Richter
L
L
Reinholdsson
G
G
Roberts
T M
TM
Schaffhausen
B S
BS
Dalianis
T
T
D000818:Animals; D000917:Antibody Formation; D000951:Antigens, Neoplasm / Q000276:immunology*; D000952:Antigens, Polyomavirus Transforming / Q000008:administration & dosage* / Q000235:genetics; D006649:Histocompatibility Antigens / Q000276:immunology*; D007114:Immunization; D051379:Mice; D011120:Polyomavirus / Q000276:immunology*; D011994:Recombinant Proteins / Q000008:administration & dosage; D014412:Tumor Virus Infections / Q000473:pathology / Q000517:prevention & control*; D014765:Viral Vaccines / Q000008:administration & dosage*
D000951:Antigens, Neoplasm; D000952:Antigens, Polyomavirus Transforming; D006649:Histocompatibility Antigens; D011994:Recombinant Proteins; D014765:Viral Vaccines; C029237:tumor-associated transplantation antigen