title: Circulating activities during constant infusion of heparin or a low molecular weight derivative (enoxaparine): failure to demonstrate any circadian variations.
abstract: We compared in six patients successively treated with an unfractionated heparin (UFH) and a low molecular weight heparin (LMWH) the variations in plasma anti-Xa activity, measured in a chromogenic assay, during a 36 h constant infusion. The values varied in a wider range during UHF infusion, but remained in the therapeutic range except once in one patient. No circadian rhythm could be demonstrated in our six patients. LMWH infusion yielded very constant anti-Xa circulating activities. In both cases, there were no significant modifications of three proteins with high heparin affinity (antithrombin III, heparin cofactor II, histidine-rich glycoprotein). Our results suggest that the circadian rhythm of the biological activities previously observed in patients treated with constant heparin infusion using clotting method is due to other factors than heparin itself.
authors.affiliation: Centre de Recherche Claude-Bernard sur les maladies vasculaires périphériques et Hôpital Broussais, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Toulon
authors.forename: J F
authors.initials: JF
authors.lastname: Vitoux
authors.forename: C
authors.initials: C
authors.lastname: Leroy
authors.forename: T
authors.initials: T
authors.lastname: Lecomte
authors.forename: M
authors.initials: M
authors.lastname: Roncato
authors.forename: Y
authors.initials: Y
authors.lastname: Motobashi
authors.forename: M
authors.initials: M
authors.lastname: Aiach
authors.forename: J N
authors.initials: JN
authors.lastname: Fiessinger
mesh_terms: D000328:Adult; D000368:Aged; D002940:Circadian Rhythm; D015951:Factor Xa; D006493:Heparin / Q000008:administration & dosage* / Q000097:blood; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D015842:Serine Proteinase Inhibitors; D014652:Vascular Diseases / Q000097:blood / Q000188:drug therapy
chemical_list: D006495:Heparin, Low-Molecular-Weight; D015842:Serine Proteinase Inhibitors; D006493:Heparin; D015951:Factor Xa