[Morphofunctional changes in a culture of pancreatic islet cells from newborn piglets as affected by Coxsackie B3 viruses].
The direct influence of Coxsackie virus B-3 and its selected variants Abent+ and Abent- on the function and structure of neonatal pig pancreatic islet cells in monolayer cultures was studied. The viruses under study possessed cytopathogenic activity and were capable of reproduction. The Abent- variant of Coxsackie virus B-3 possessed the most pronounced cytopathogenic activity. Direct correlation between virus reproduction and insulin concentration in a culture medium was established.
Komissarenko
V P
VP
Turchin
I S
IS
Shirobokov
V P
VP
Zemlianskiĭ
V V
VV
Zhurba
T B
TB
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D029822:Enterovirus B, Human / Q000472:pathogenicity* / Q000502:physiology; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D009154:Mutation; D013552:Swine; D013997:Time Factors; D014779:Virus Replication
D007328:Insulin
Morfofunktsional'nye izmeneniia v kul'ture ostrovkovykh kletok podzheludochnoĭ zhelezy novorozhdennykh porosiat pod vliianiem virusov Koksaki B3.