title: Rise in plasma beta-endorphin, ACTH, and cortisol in cancer patients undergoing whole body hyperthermia.
abstract: It has been previously reported that sauna-induced fevers (approximately 39 degrees C) result in rises of beta-endorphins in normal volunteers. This report describes changes in plasma beta-endorphins in cancer patients undergoing whole body hyperthermia (40.5 degrees C to 41.8 degrees C). Results presented show that there is a linear relationship between thermal stress, defined in terms of core temperature and/or duration of hyperthermia, and the quantitative rise in plasma beta-endorphin levels. Data relating to changes in ACTH and cortisol levels are in a single temperature range (41.5 degrees C--41.8 degrees C) are also reported.
authors.affiliation: Department of Human Oncology, University of Wisconsin Clinical Cancer Center, Madison.
authors.forename: H I
authors.initials: HI
authors.lastname: Robins
authors.forename: N H
authors.initials: NH
authors.lastname: Kalin
authors.forename: S E
authors.initials: SE
authors.lastname: Shelton
authors.forename: P A
authors.initials: PA
authors.lastname: Martin
authors.forename: L M
authors.initials: LM
authors.lastname: Shecterle
authors.forename: C M
authors.initials: CM
authors.lastname: Barksdale
authors.forename: A J
authors.initials: AJ
authors.lastname: Neville
authors.forename: J
authors.initials: J
authors.lastname: Marshall
mesh_terms: D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D003110:Colonic Neoplasms / Q000097:blood / Q000628:therapy; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D006979:Hyperthermia, Induced; D008297:Male; D008545:Melanoma / Q000097:blood / Q000628:therapy; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000628:therapy*; D010190:Pancreatic Neoplasms / Q000097:blood / Q000628:therapy; D012509:Sarcoma / Q000097:blood / Q000628:therapy; D001615:beta-Endorphin / Q000097:blood*
chemical_list: D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone