Blood lipid peroxides in TIA: relation to platelet function and metabolic profile.
Patients with transient ischemic attacks (TIA) were previously shown to have high plasma values of thiobarbituric acid-reactive substances (TBA-RS). To study whether these changes could be related to platelet activability, TBA-RS was investigated in 24 TIA patients before and 24 h after 1 g aspirin, an inhibitor of platelet cyclooxygenase pathway. Baseline TBA-RS values were significantly higher in TIA than in controls. Conversely, TIA patients had TBA-RS values after aspirin similar to controls, suggesting that the increase of plasma TBA-RS was not attributable to platelet hyperfunction. The evaluation of metabolic profile showed that patients with highest TBA-RS had hypercholesterolemia, hypertriglyceridemia, and/or diabetes mellitus. This study suggests that the increase of plasma TBA-RS in TIA could be an epiphenomenon of altered metabolic pathway.
Violi
F
F
Institute of Clinical Medicine I, University La Sapienza, Rome, Italy.
Alessandri
C
C
Ghiselli
A
A
Germani
M
M
Caliendo
C
C
Censi
C
C
Servi
M
M
Balsano
F
F
D000284:Administration, Oral; D000368:Aged; D001161:Arteriosclerosis / Q000097:blood; D001241:Aspirin / Q000008:administration & dosage; D001786:Blood Glucose / Q000032:analysis; D001792:Blood Platelets / Q000502:physiology*; D003327:Coronary Disease / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood; D002546:Ischemic Attack, Transient / Q000097:blood*; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013858:Thiobarbiturates / Q000097:blood*
D001786:Blood Glucose; D008054:Lipid Peroxides; D013858:Thiobarbiturates; C029684:thiobarbituric acid; D001241:Aspirin