Changes in bronchial response after Sendai virus infection in guinea pigs.
Enhanced bronchial reactivity to inhaled histamine was observed in guinea pigs infected with Sendai virus with concomitant decrease of beta-adrenergic receptor density in the pulmonary parenchyma 2 to 3 weeks after the inoculation. Histologic examination of the bronchi showed shedding of epithelial cells with a marked infiltration of mononuclear cells. These observations suggest that damage of the bronchial epithelium and decreased density of beta-adrenergic receptor may be the causes of observed bronchial reactivity.
Ohashi
Y
Y
Department of Medicine and Clinical Immunology, Dokkyo University School of Medicine, Tochigi, Japan.
Motojima
S
S
Yamanouchi
K
K
Makino
S
S
D000280:Administration, Inhalation; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001980:Bronchi / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D004848:Epithelium / Q000473:pathology; D006168:Guinea Pigs; D006632:Histamine / Q000008:administration & dosage; D008297:Male; D010222:Parainfluenza Virus 1, Human; D018184:Paramyxoviridae Infections / Q000503:physiopathology*; D013997:Time Factors
D000914:Antibodies, Viral; D006632:Histamine