Effects of ethylketocyclazocine on behaviors in mice using multi-dimensional behavioral analyses.
The effects of ethylketocyclazocine, a relatively selective kappa opioid agonist on the behaviors in mice were examined by using multi-dimensional behavioral analyses. Within 15 min after the measurements, ethylketocyclazocine (0.03, 0.1 and 0.3 mg/kg) dose-dependently decreased the linear locomotion, rearing, and grooming behaviors in mice. Fifteen to 30 min ethylketocyclazocine (0.3 mg/kg) decreased most of the behaviors in mice. The ethylketocyclazocine (0.3 mg/kg)-induced behavioral effects were antagonized by naloxone (1 and 2 mg/kg). These data suggest that the decreases in the linear locomotion, rearing and grooming behaviors are mediated via kappa opioid system.
Ukai
M
M
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Kameyama
T
T
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003496:Cyclazocine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D016314:Ethylketocyclazocine; D006120:Grooming / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D011957:Receptors, Opioid / Q000378:metabolism; D017473:Receptors, Opioid, kappa; D013997:Time Factors
D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D009270:Naloxone; D016314:Ethylketocyclazocine; D003496:Cyclazocine