title: Signet-ring cells in advanced gastric cancer. A clinical, pathological and histochemical study.
abstract: A pathological and histochemical study on the presence of signet-ring cells (SRC) in 108 advanced gastric cancer (AGC) has been evaluated. According to Laurén's classification, 59 were of intestinal (I) and 49 of diffuse (D) type. The amount of SRC seems to be a prognostic parameter in D-carcinoma: the 5-year survival rate was 49% and 22% in cases with 1-24% and 75-100% SRC, respectively. Histochemically, in our series of SRC D-carcinoma the quality of mucin secretion of SRC closely resembled the goblet cells of intestinal metaplasia. The histogenetic origin of D-gastric carcinoma was discussed.
authors.forename: D
authors.initials: D
authors.lastname: Santini
authors.forename: F
authors.initials: F
authors.lastname: Bazzocchi
authors.forename: G
authors.initials: G
authors.lastname: Mazzoleni
authors.forename: M
authors.initials: M
authors.lastname: Ricci
authors.forename: G
authors.initials: G
authors.lastname: Viti
authors.forename: D
authors.initials: D
authors.lastname: Marrano
authors.forename: G
authors.initials: G
authors.lastname: Martinelli
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000401:mortality / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D011379:Prognosis; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*