title: Enhancement of mitochondrial tyrosine kinase activity following viral transformation.
abstract: A tyrosine protein kinase activity has been detected in the mitochondrial fraction purified from normal and virus-transformed cultured cells. The addition of serum to cells whose growth was restricted by serum limitation induced a marked decrease of tyrosine kinase activity associated with the mitochondrial fraction. At all the culture conditions tested this enzyme activity always resulted several fold higher in the virus-transformed cells than in the normal parental cells.
authors.affiliation: Istituto di Patologia Generale, Università di Parma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Piedimonte
authors.forename: L
authors.initials: L
authors.lastname: Silvotti
authors.forename: A F
authors.initials: AF
authors.lastname: Borghetti
authors.forename: L
authors.initials: L
authors.lastname: Montagnier
mesh_terms: D000818:Animals; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D003470:Culture Media; D008928:Mitochondria / Q000201:enzymology*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D013539:Simian virus 40
chemical_list: D003470:Culture Media; D011505:Protein-Tyrosine Kinases