title: Different plasticity changes in D1 and D2 receptors in rat striatal subregions following impairment of dopaminergic transmission.
abstract: The precise topographical changes in striatal D1 and D2 dopamine receptor density that occurred after chronic treatment with haloperidol or SCH 23390 or after 6-hydroxydopamine-induced lesion of the mesostriatal dopaminergic pathway have been studied autoradiographically in the rat. Repeated treatment with SCH 23390 (0.5 mg/kg i.p., 21 days) caused an almost similar increase in [3H]SCH 23390 binding sites in the different striatal subregions whereas lesion of the dopaminergic pathway was ineffective. Subacute administration of haloperidol (2 mg/kg i.p., 18 days) or lesion of dopaminergic afferents provoked an increase in [3H]spiperone binding which was restricted to the ventro- and dorsolateral striatal sectors.
authors.affiliation: Laboratoires d'Etudes et de Recherches Synthélabo (L.E.R.S.), Biology Department, Bagneux, France.
authors.forename: M
authors.initials: M
authors.lastname: Savasta
authors.forename: A
authors.initials: A
authors.lastname: Dubois
authors.forename: J
authors.initials: J
authors.lastname: Benavidès
authors.forename: B
authors.initials: B
authors.lastname: Scatton
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D006220:Haloperidol; D006892:Hydroxydopamines; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D013134:Spiperone / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D001552:Benzazepines; D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D013134:Spiperone; D016627:Oxidopamine; D006220:Haloperidol; D004298:Dopamine