title: [Animal experiment studies of callus formation by hydroxyapatite injection].
abstract: Hydroxy-apatite may be suspended well in liquid high-molecular gelatine. This renders possible an application by local injection. By means of experimental animal investigations in 64 rabbits it could be proved, that hydroxy-apatite stimulates osteogenesis and local callus formation when being injected at artificial bone defects. Gelatine on its own without any HA-grains only leads to a callus-free bridging of the bone defect. In case of an injection of the HA-suspensions to muscular soft tissue, no stimulation of the osteogenesis could be proved. It has to be concluded, that hydroxy-apatite stimulates osteogenesis. To achieve this effect, a direct contact to osteogenetic cells is necessary.
authors.affiliation: Orthopädische Universitätsklinik Homburg/Saar.
authors.forename: J
authors.initials: J
authors.lastname: Heisel
mesh_terms: D000818:Animals; D002146:Bony Callus / Q000187:drug effects* / Q000473:pathology; D004195:Disease Models, Animal; D017886:Durapatite; D005269:Femur / Q000187:drug effects / Q000473:pathology; D006882:Hydroxyapatites / Q000008:administration & dosage*; D007267:Injections; D011817:Rabbits
chemical_list: D006882:Hydroxyapatites; D017886:Durapatite
vernacular_title: Tierexperimentelle Untersuchungen zur Kallusformation durch Hydroxylapatit-Injektion.