Lack of effect of the benzodiazepine receptor antagonist Ro 15-1788 on ethanol-induced intoxication in mice.
The effects of 3, 6 and 48 mg/kg of the benzodiazepine receptor antagonist Ro 15-1788 on the ethanol-induced depressant action were evaluated in mice. These results support and extend previous findings in experimental animals and show that Ro 15-1788 in doses devoid of intrinsic effects, does not antagonize the motor impairment, hypnotic effect or lethality induced by ethanol.
Masur
J
J
Departamento de Psicobiologia, Escola Paulista de Medicina, São Paulo, Brasil.
Silva-Filho
A R
AR
de Souza
M L
ML
Pires
M L
ML
D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D005442:Flumazenil / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects
D011963:Receptors, GABA-A; D005442:Flumazenil