Effects of IGF-I on proliferation and steroidogenesis of cultured adrenal zona glomerulosa cells.
In a primary culture of bovine adrenal zona glomerulosa cells, insulin-like growth factor I (IGF-I)/somatomedin C stimulated DNA synthesis, as measured by [3H] thymidine uptake, at concentrations of 10(-9) and 10(-7) M. IGF-I also prevented ACTH-induced suppression of [3H] thymidine uptake. IGF-I in no way affected aldosterone secretion during short-term exposure to cultured cells, however. Our findings suggest that IGF-I plays an important role in the proliferation of adrenal zona glomerulosa cells.
Horiba
N
N
Department of Medicine, Tokyo Women's Medical College, Japan.
Nomura
K
K
Hizuka
N
N
Takano
K
K
Demura
H
H
Shizume
K
K
D000302:Adrenal Cortex / Q000166:cytology* / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D013002:Somatomedins / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism
D013002:Somatomedins; D000450:Aldosterone; D007334:Insulin-Like Growth Factor I; D000324:Adrenocorticotropic Hormone; D013936:Thymidine