Effect of immunoglobulin G therapy on serum antibody titers to cytomegalovirus in burn patients.
We attempted to determine the incidence and significance of cytomegalovirus infection and the effect of immunoglobulin G infusions on specific cytomegalovirus titers in burn patients. On admission, 48 percent of a group of 120 patients (mean burn size 28.5 percent of the total body surface area) were seronegative, including 95 percent of all patients under 20 years of age. Subsequently, 4 of a subgroup of 26 patients (15 percent) had development of a primary infection, and 1 of these patients died from overwhelming bacterial infection. Immunoglobulin G infusion used in the prophylaxis of the septic complications achieved high titers of cytomegalovirus-specific immunoglobulin G, as well as the subsets immunoglobulin G1 and immunoglobulin G3 which are also active against cytomegalovirus.
Moran
K T
KT
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Thupari
J N
JN
O'Reilly
T J
TJ
Munster
A M
AM
D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology*; D002056:Burns / Q000150:complications*; D002986:Clinical Trials as Topic; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D008297:Male; D011897:Random Allocation; D014946:Wound Infection / Q000517:prevention & control*
D000914:Antibodies, Viral; D007074:Immunoglobulin G