title: Neuropathy and IgM paraproteinemia: differential binding of IgM M-proteins to peripheral nerve glycolipids.
abstract: Two patients with neuropathy and IgM paraproteinemia displayed different immunoreactivity to acidic peripheral nerve glycolipids. In one patient, immunostaining on thin-layer chromatographic plate revealed binding of the IgM to sulfated glucuronosyl paragloboside (SGPG) and sulfated glucuronosyl lactosaminyl paragloboside (SGLPG). The other IgM bound SGPG, SGLPG, and a new third glycolipid. Immunoreactivity of the IgM varies in this syndrome.
authors.affiliation: Department of Neurology, Yale University School of Medicine, New Haven, CT 06510.
authors.forename: S
authors.initials: S
authors.lastname: Kusunoki
authors.forename: T
authors.initials: T
authors.lastname: Kohriyama
authors.forename: A R
authors.initials: AR
authors.lastname: Pachner
authors.forename: N
authors.initials: N
authors.lastname: Latov
authors.forename: R K
authors.initials: RK
authors.lastname: Yu
mesh_terms: D000368:Aged; D002855:Chromatography, Thin Layer; D006017:Glycolipids / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology* / Q000302:isolation & purification; D008297:Male; D009132:Muscles / Q000503:physiopathology; D010265:Paraproteinemias / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D011485:Protein Binding
chemical_list: D006017:Glycolipids; D007075:Immunoglobulin M