title: Passive serum antibody causes temporary recovery from influenza virus infection of the nose, trachea and lung of nude mice.
abstract: BALB/c normal and nude mice were infected with a non-lethal mouse-passaged A/PC/1/73 (H3N2) influenza virus in order to assess the role of T cells on the course of disease of the nose, trachea and lung. The tracheal epithelium of both mouse strains was desquamated by 3 days after infection. Although normal regeneration began, nude mice never completed that regeneration whereas normal mice had fully regenerated tracheas by Day 14. This failure to complete the recovery was also evident from the continued virus shedding by the nude mouse. In order to assess the role of serum antibody on recovery from infection, ferret, goat or mouse antibody to H3N2 influenza virus was passively administered to nude mice after infection. It resulted in a transient decrease in virus shedding from the nose, trachea and lung, and complete but temporary regeneration of the tracheal epithelium. However, later in the course of the infection, when serum antibody levels were no longer detectable, the tracheal epithelium of these animals redesquamated and large amounts of virus were again shed from nose, trachea and lungs. We conclude that: (i) desquamation of the ciliated epithelium of the trachea is not T-cell dependent; and (ii) serum antibody can contribute to temporary recovery from infection, but by itself is insufficient for permanent recovery of the nose, trachea or lung.
authors.affiliation: Biotechnology Research Center, Rockville, Maryland.
authors.forename: R M
authors.initials: RM
authors.lastname: Kris
authors.forename: R A
authors.initials: RA
authors.lastname: Yetter
authors.forename: R
authors.initials: R
authors.lastname: Cogliano
authors.forename: R
authors.initials: R
authors.lastname: Ramphal
authors.forename: P A
authors.initials: PA
authors.lastname: Small
mesh_terms: D000818:Animals; D005289:Ferrets; D006041:Goats; D007116:Immunization, Passive; D009980:Influenza A virus; D008168:Lung / Q000382:microbiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008855:Microscopy, Electron, Scanning; D009666:Nose / Q000382:microbiology*; D009976:Orthomyxoviridae Infections / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D014132:Trachea / Q000382:microbiology* / Q000648:ultrastructure