MPDP+ causes a non-reversible decrease in neostriatal synaptic transmission in mouse brain slice.
MPTP causes a Parkinson's disease-like syndrome in man and certain other animals. The toxic effect occurs if monoamine oxidase B is available, indicating that an MPTP metabolite may cause the toxic effect. We tested the effect of MPDP+, the first product of MPTP oxidation, and found that it, like MPTP, caused a non-reversible decrease in synaptic transmission in the mouse brain slice preparation. As the second oxidation product, MPP+ had been shown not to cause a similar, non-reversible decrease in synaptic transmission, MPDP+ is a better candidate for the role of toxic substance.
Wilson
J A
JA
Laboratory of Preclinical Studies, National Institute on Alcohol, Abuse and Alcoholism, Rockville, MD 20852.
Wilson
J S
JS
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D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D066298:In Vitro Techniques; D051379:Mice; D010293:Pargyline / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*
D011726:Pyridinium Compounds; C044755:1-methyl-4-phenyl-2,3-dihydropyridinium; D010293:Pargyline