title: Pentavalent [99mTc]DMSA, [131I]MIBG, and [99mTc]MDP--an evaluation of three imaging techniques in patients with medullary carcinoma of the thyroid.
abstract: Nine patients with histologically proven medullary carcinoma of the thyroid (MCT) were imaged using pentavalent [99mTc]dimercaptosuccinic acid [(V)DMSA], [131I] metaiodobenzylguanidine (MIBG) and [99mTc]methylene diphosphonate (MDP). Technetium-99m (V)DMSA demonstrated most of the tumor sites in eight patients with proven metastases, with an overall sensitivity of 95% in lesion detection. Iodine-131 MIBG showed definite uptake in some of the tumor sites in three of the nine patients imaged, with equivocal uptake seen in a further one patient, with sensitivity of only 11% for lesion detection. Technetium-99m MDP demonstrated bony metastases only, in four of the patients imaged yielding a sensitivity of 61%. Technetium-99m (V)DMSA has been demonstrated in this study to be a useful imaging agent in patients with MCT, showing uptake in significantly more lesions and with better imaging qualities than [131I]MIBG, and with the ability to detect soft tissue as well as bony metastases.
authors.affiliation: Department of Nuclear Medicine, Guy's Hospital, London, England.
authors.forename: S E
authors.initials: SE
authors.lastname: Clarke
authors.forename: C R
authors.initials: CR
authors.lastname: Lazarus
authors.forename: P
authors.initials: P
authors.lastname: Wraight
authors.forename: C
authors.initials: C
authors.lastname: Sampson
authors.forename: M N
authors.initials: MN
authors.lastname: Maisey
mesh_terms: D019797:3-Iodobenzylguanidine; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000556:secondary; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D009942:Organometallic Compounds; D011877:Radionuclide Imaging; D004113:Succimer; D013438:Sulfhydryl Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013669:Technetium Tc 99m Medronate; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; D019797:3-Iodobenzylguanidine; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer; D013669:Technetium Tc 99m Medronate