The significance of human papilloma virus atypia ('wart virus infection') found alone on cervical cytology screening.
A series of 429 patients has been analysed in which the cytology smear report suggested human papillomavirus (HPV) infection alone. All patients were examined colposcopically and in 58 (13.6%) associated histologically confirmed cervical intraepithelial neoplasia (CIN) was demonstrated. CIN subsequently developed in an additional 10% of those patients who returned for follow-up over an ensuing 3-year period. Follow-up with repeat cervical cytology smears alone was unreliable as 4% of patients even with normal repeat smears has histologically proven CIN and a further 4% of these patients subsequently developed CIN. Colposcopy is recommended in all patients whose cytology smear shows HPV infection.
Pagano
R
R
Colposcopy and Dysplasia Unit, Royal Women's Hospital, Melbourne.
Chanen
W
W
Rome
R M
RM
Johnstone
N R
NR
D000293:Adolescent; D000328:Adult; D000368:Aged; D003127:Colposcopy; D003581:Cytodiagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000473:pathology; D002577:Uterine Cervical Diseases / Q000453:epidemiology* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology; D014860:Warts / Q000453:epidemiology