title: [Effect of ritmilen and allapinin on prostanoid and cyclic nucleotide levels in patients with cardiac rhythm disorders].
abstract: The effect of antiarrhythmic drugs, ritmilen and allapinin, on endogenic prostanoid and cyclic nucleotide levels was examined in patients with heart rhythm disorders. Intravenous administration of antiarrhythmic agents is shown to be accompanied with increased release of prostacyclin that has antiarrhythmic properties into myocardial outflow. Both ritmilen and allapinin promoted the predominance of prostacyclin over thromboxane, with its intrinsic arrhythmogenic properties. Ritmilen- or allapinin-induced changes in prostaglandins E and F2 alpha consisted in that PGE prevailed, as compared to PGF2 alpha. There were no significant changes in cyclic nucleotide ratios (cAMP/cGMP) in response to treatment.
authors.forename: A S
authors.initials: AS
authors.lastname: Smetnev
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Bunin
authors.forename: I E
authors.initials: IE
authors.lastname: Smirnov
authors.forename: E U
authors.initials: EU
authors.lastname: Asymbekova
authors.forename: A P
authors.initials: AP
authors.lastname: Savchenko
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives*; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000188:drug therapy*; D000242:Cyclic AMP / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D015237:Dinoprost; D004206:Disopyramide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009712:Nucleotides, Cyclic / Q000097:blood*; D011453:Prostaglandins / Q000097:blood*; D011458:Prostaglandins E / Q000097:blood; D011460:Prostaglandins F / Q000097:blood; D013268:Stimulation, Chemical
chemical_list: D000889:Anti-Arrhythmia Agents; D009712:Nucleotides, Cyclic; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; C051402:allapinin; D015237:Dinoprost; D000242:Cyclic AMP; D004206:Disopyramide; D006152:Cyclic GMP; D000157:Aconitine
vernacular_title: Vliianie ritmilena i allapinina na soderzhanie prostanoidov i tsiklicheskikh nukleotidov u bol'nykh s narusheniiami ritma serdtsa.