title: Combination therapy of theophylline and terbutaline as sustained-release preparations in patients with asthmatic bronchitis.
abstract: In a group of ten patients with chronic asthmatic bronchitis, the effect of monotherapy with theophylline and terbutaline and the combination of both drugs, as sustained-release tablets, was compared to placebo, in a double-blind cross-over, triple dummy at random study. Lung function parameters, tremor measurements, c-AMP plasma levels, theophylline- and terbutaline-plasma levels were determinated. Monotherapy with theophylline and terbutaline in a relatively low dosage achieved a good lung function improvement without severe side effects, as compared to placebo. The combination of both drugs in the same dosage achieved a statistically significant enhancement of the lung function improvement, as compared to monotherapy, without an increase of side effects. An additional effect of theophylline and terbutaline on bronchodilation is demonstrated.
authors.affiliation: Department of Pulmonology, University Hospital Maastricht, University of Limburg, The Netherlands.
authors.forename: A P
authors.initials: AP
authors.lastname: van der Vet
authors.forename: J
authors.initials: J
authors.lastname: Kreukniet
authors.forename: R H
authors.initials: RH
authors.lastname: van Drost
authors.forename: R A
authors.initials: RA
authors.lastname: Maes
authors.forename: J K
authors.initials: JK
authors.lastname: Fokkens
authors.forename: M J
authors.initials: MJ
authors.lastname: Hamelink
mesh_terms: D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D000242:Cyclic AMP / Q000097:blood; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012129:Respiratory Function Tests; D013726:Terbutaline / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D013806:Theophylline / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D014202:Tremor / Q000139:chemically induced
chemical_list: D003692:Delayed-Action Preparations; D013806:Theophylline; D000242:Cyclic AMP; D013726:Terbutaline