title: Vaccination to protect calves against infectious bovine rhinotracheitis.
abstract: A commercially available inactivated vaccine against infectious bovine rhinotracheitis (BHV1) was tested to assess its ability to immunise young seronegative calves and protect them against challenge with a virulent strain of BHV1. Calves showed seroconversion after one or two doses of vaccine. A two-dose and three-dose vaccination regimen each afforded calves significant protection against challenge as judged by the development of clinical symptoms. Vaccinated calves were on average 7 to 10 kg heavier than control calves 24 days after challenge, a statistically significant difference. Vaccination had no significant effect on the virus excretion pattern after challenge.
authors.affiliation: Bundesforschungsanstalt, Tübingen, Federal Republic of Germany.
authors.forename: O C
authors.initials: OC
authors.lastname: Straub
authors.forename: I C
authors.initials: IC
authors.lastname: Mawhinney
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001835:Body Weight; D002417:Cattle; D007242:Herpesvirus 1, Bovine / Q000254:growth & development / Q000276:immunology*; D007241:Infectious Bovine Rhinotracheitis / Q000517:prevention & control*; D009297:Nasal Mucosa / Q000382:microbiology; D011897:Random Allocation; D014611:Vaccination / Q000662:veterinary*; D014765:Viral Vaccines
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines