Dextrorphan: an antagonist for phencyclidine receptor.
Radio-binding assay, bioassay and HPLC detection were used to observe the antagonistic effects of dextrorphan on PCP's actions. Dextrorphan displayed high affinity to PCP receptors and it had weak PCP-like bioactivity, but could antagonize PCP's action dose-dependently in vitro and shift the dose-response curve to the right. PCP increased the contents of norepinephrine in bath medium, which was reversed by dextrorphan. Thus, the results suggest that dextrorphan is a partial antagonist for PCP receptors.
Sun
F Y
FY
Dept. of Neurobiology, Shanghai Medical University, China.
Zhu
H
H
Zhang
L M
LM
Xu
X R
XR
Zhang
A Z
AZ
D000818:Animals; D001808:Blood Vessels / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003917:Dextrorphan / Q000494:pharmacology*; D066298:In Vitro Techniques; D009019:Morphinans / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D010622:Phencyclidine / Q000378:metabolism / Q000494:pharmacology; D011817:Rabbits; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D017478:Receptors, Phencyclidine
D009019:Morphinans; D017981:Receptors, Neurotransmitter; D011957:Receptors, Opioid; D017478:Receptors, Phencyclidine; D003917:Dextrorphan; D010622:Phencyclidine; D009638:Norepinephrine