Subacute sensory neuronopathy associated with small cell lung carcinoma: diagnosis aided by autoimmune serology.
In two patients with subacute sensory neuronopathy associated with small cell carcinoma of the lung, the diagnosis of the paraneoplastic syndrome was aided by the finding, in highly diluted serum (1/500 and 1/2,000, respectively), of unusual and distinctive antinuclear antibodies with reactivity restricted to neuronal nuclei. Magnetic resonance imaging of the chest was instrumental in detecting both lung cancers.
Kimmel
D W
DW
Department of Neurology, Mayo Clinic, Rochester, MN 55905.
O'Neill
B P
BP
Lennon
V A
VA
D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis*; D000912:Antibodies, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000276:immunology*; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology / Q000276:immunology*; D012677:Sensation
D000974:Antibodies, Antinuclear; D000912:Antibodies, Neoplasm; D014408:Biomarkers, Tumor