NGF receptor immunoreactivity in rat brain: topographic distribution and response to entorhinal ablation.
Nerve growth factor receptor (NGFR) immunoreactivity was distributed in neuronal cell bodies, axons and/or dendrites of cholinergic and non-cholinergic structures of the rat brain. The dentate gyrus of normal animals showed immunostained fibers mainly in the supragranular band, whereas following entorhinal ablation a greater density of immunostained fibers appeared in the outer molecular layer and a wider clear zone was apparent in the inner molecular layer. The NGFR-positive fibers followed the pattern of reorganization of septal fibers visualized with acetylcholinesterase staining. The results suggest that the NGF/NGFR may have a role in reorganization of septal fibers following entohinal lesion.
Gomez-Pinilla
F
F
Department of Psychobiology, University of California, Irvine 92717.
Cotman
C W
CW
Nieto-Sampedro
M
M
D000818:Animals; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000502:physiology*; D006624:Hippocampus / Q000032:analysis; D009414:Nerve Growth Factors / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000032:analysis*; D017475:Receptors, Nerve Growth Factor
D009414:Nerve Growth Factors; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor