Effects of extracellular fluid volume changes on renal response to low-dose dopamine infusion in normal women.
Dopamine (DA) i.v. infused in a low dose (0.1 microgram/kg/min) in healthy women during sustained hypotonic polyuria, produced different renal functional effects as variations in extracellular fluid volume occurred. (1) In hydro-saline retention (n = 23), induced by desoxycorticosterone acetate treatment, DA produced typical vasodilator and hydro-natriuretic effects (Goldberg, 1972). (2) In hydro-saline depletion (n = 19), induced by diuretic treatment and low dietary sodium intake, DA lost its vasodilator and natriuretic efficacy, manifesting, on the other hand, renal sodium conserving effects mainly dependent on the increase in distal sodium reabsorption and a trend towards afferent arteriolar vasoconstriction. (3) Treatment with prazosin (n = 9) or propranolol (n = 9) in hydro-saline depletion, was efficacious in partly restoring the typical vasodilator and natriuretic effects of DA. Thus, in hydro-saline depletion, DA produced sympathomimetic effects which were sufficiently intense to outweigh those due to activation of specific DA renal receptors.
Agnoli
G C
GC
Istituto di Clinica Medica II dell'Università di Bologna, Italy.
Cacciari
M
M
Garutti
C
C
Ikonomu
E
E
Lenzi
P
P
Marchetti
G
G
D000328:Adult; D001834:Body Water / Q000378:metabolism; D003900:Desoxycorticosterone / Q000494:pharmacology; D004298:Dopamine / Q000008:administration & dosage*; D005110:Extracellular Space / Q000502:physiology*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology; D012079:Renal Circulation / Q000187:drug effects; D012964:Sodium / Q000378:metabolism; D014655:Vascular Resistance / Q000187:drug effects
D011943:Receptors, Adrenergic, beta; D003900:Desoxycorticosterone; D012964:Sodium; D011433:Propranolol; D004298:Dopamine; D011224:Prazosin