Influence of thyroid hormones and testosterone on the activities of hepatic mitochondrial enzymes in the Indian garden lizard, Calotes versicolor.
Thyroidectomy and castration in Calotes versicolor significantly decreased the activities of hepatic mitochondrial cytochrome oxidase, alpha-glycerophosphate dehydrogenase (alpha-GPDH), and succinate dehydrogenase (SDH) when compared to sham-operated controls. Administration of thyroid hormones in thyroidectomized lizards and testosterone in castrated specimens stimulated the activities of all three enzymes studied. Chloramphenicol, when injected with thyroxine prevented the hormone-stimulated activities of cytochrome oxidase and SDH, while actinomycin D and chloramphenicol, when administered along with testosterone propionate (low dose) prevented the testosterone-stimulated activities of cytochrome oxidase and alpha-GPDH.
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Department of Zoology, University of Kerala, Trivandrum, India.
Sreedeviamma
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KK
D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D003576:Electron Transport Complex IV / Q000378:metabolism; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D008116:Lizards / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D009919:Orchiectomy; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013739:Testosterone / Q000494:pharmacology*; D013963:Thyroid Hormones / Q000494:pharmacology*; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology; D014284:Triiodothyronine / Q000494:pharmacology
D013963:Thyroid Hormones; D014284:Triiodothyronine; D003609:Dactinomycin; D013739:Testosterone; D002701:Chloramphenicol; D005993:Glycerolphosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D013974:Thyroxine