Tn1331, a novel multiresistance transposon encoding resistance to amikacin and ampicillin in Klebsiella pneumoniae.
A 7.5-kilobase-pair multiresistance transposon, Tn1331, harboring amikacin resistance was identified as part of Klebsiella pneumoniae plasmid pJHCMW1. Restriction mapping, hybridization, and transposition complementation experiments demonstrated that Tn1331 belongs to the Tn3 family. Its structure is similar to that of Tn3 with the insertion of a DNA fragment encoding resistance to amikacin, kanamycin, and tobramycin.
Tolmasky
M E
ME
Department of Microbiology and Immunology, School of Medicine, Oregon Health Sciences University, Portland 97201.
Crosa
J H
JH
D000583:Amikacin / Q000494:pharmacology*; D000667:Ampicillin / Q000494:pharmacology*; D000668:Ampicillin Resistance; D003227:Conjugation, Genetic; D004262:DNA Restriction Enzymes; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000235:genetics; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010957:Plasmids
D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D000667:Ampicillin; D000583:Amikacin; D004262:DNA Restriction Enzymes