title: Enhanced histamine- and beta-adrenoceptor-mediated cyclic AMP formation in leukocytes from patients with endogenous depression.
abstract: Beta-adrenoceptor-mediated cyclic AMP formation was found to be increased in leukocytes from manic-depressive patients during untreated depression when compared with euthymic patients treated with antidepressants. The difference was dependent on the stimulation used (isoprenaline or a combination of noradrenaline and phentolamine) and was only significant when the combination was used. Histamine-stimulated cyclic AMP formation in leukocytes was enhanced in patients with untreated depression, both when compared with euthymic patients suffering from manic-depressive illness, with or without treatment with antidepressant drugs, and also when compared with control persons without any known psychiatric disease. Although at variance with the results of some other studies on the same topic, the results of the present study indicate that changes in receptor function in leukocytes may be a state-dependent marker in depressive illness.
authors.affiliation: Department of Pharmacology, University of Copenhagen, Denmark.
authors.forename: R
authors.initials: R
authors.lastname: Klysner
authors.forename: A
authors.initials: A
authors.lastname: Geisler
authors.forename: R
authors.initials: R
authors.lastname: Rosenberg
mesh_terms: D000328:Adult; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000503:physiopathology; D000242:Cyclic AMP / Q000097:blood*; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006632:Histamine / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology*; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D011968:Receptors, Histamine / Q000187:drug effects / Q000502:physiology
chemical_list: D000929:Antidepressive Agents, Tricyclic; D011943:Receptors, Adrenergic, beta; D011968:Receptors, Histamine; D006632:Histamine; D008094:Lithium; D000242:Cyclic AMP