title: Malabsorption of flucytosine in a pediatric patient with Shwachman syndrome.
abstract: The malabsorption of drugs from the gastrointestinal tract in patients with pancreatic insufficiency is not well documented in the literature. We describe a case of flucytosine malabsorption in a pediatric patient with Shwachman syndrome, a rare disease in the pediatric age group characterized by pancreatic insufficiency. A significant increase in serum concentrations of flucytosine was noted when the drug was administered in a lipophilic vehicle, possibly due to enhanced absorption.
authors.affiliation: College of Pharmacy, University of Texas, Austin.
authors.forename: K J
authors.initials: KJ
authors.lastname: Harper
authors.forename: W T
authors.initials: WT
authors.lastname: Sawyer
mesh_terms: D000328:Adult; D005437:Flucytosine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D010182:Pancreatic Diseases / Q000378:metabolism*; D013577:Syndrome
chemical_list: D005437:Flucytosine