Distinctive implication of emotional factors in various types of stress-induced analgesia.
Diazepam, an antianxietic agent, antagonized the stress-induced analgesia (SIA) distinctively depending on the characteristics of the stress. Psychological (PSY, using communication box)-SIA was completely blocked by 1 or 2 mg/kg of diazepam in the tail pinch (TP) method, but not antagonized by 1 mg/kg of the drug in the tail flick test. Swimming-SIA was resistant to diazepam in both methods and footshock-SIA was only suppressed slightly by 2 mg/kg in the TP method. Thus, emotional factors play an essential role in the production of PSY-SIA, although the participation of the factors in the other SIAs can not be excluded.
Takahashi
M
M
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University, Japan.
Tokuyama
S
S
Kaneto
H
H
D000698:Analgesia; D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D004597:Electroshock; D004644:Emotions / Q000502:physiology*; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects; D013315:Stress, Psychological / Q000503:physiopathology*; D013550:Swimming
D011957:Receptors, Opioid; D009270:Naloxone; D003975:Diazepam