[Induction of tumors of the meningeal membranes in chicks by the avian myeloblastosis virus].
The meningiomas could be easily produced by intracerebral injection of the avian myeloblastosis virus (0.01 ml of virus suspension with titer 10(9)-10(12) PFU/ml) into highly susceptible (White Leghorn Anya cross) or randomly bred newborn (24-48 hours) chicken. Tumours were observed in 66.7% highly susceptible chickens and in 33.73% of randomly bred chickens. First clinical signs of disease appeared on the 7-9th days after infection. Death occurred on the 3-4th days after beginning of the disease. Five types of tumours were detected: meningotheliomatous, fibroblastic, angiomatous, mixed and anaplastic. Our data are first description of the tumours of CNS induced by the avian myeloblastosis virus.
Tiufanov
A V
AV
D000818:Animals; D000831:Animals, Newborn; D001353:Avian Leukosis / Q000209:etiology* / Q000473:pathology; D001354:Avian Leukosis Virus / Q000472:pathogenicity*; D009189:Avian Myeloblastosis Virus / Q000472:pathogenicity*; D001921:Brain / Q000473:pathology; D002645:Chickens; D004195:Disease Models, Animal; D008577:Meningeal Neoplasms / Q000209:etiology* / Q000473:pathology; D008579:Meningioma / Q000209:etiology* / Q000473:pathology; D013997:Time Factors
Induktsiia opukholeĭ obolochek golovnogo mozga u tsypliat virusom mieloblastoza ptits.