[Dynamics of the corticotropin, cortisol and prolactin content of the blood plasma of women with Itsenko-Cushing disease administered luliberin].
The paper is concerned with the results of a study of the level of plasma ACTH, cortisol and prolactin before and after i. v. injection of LHRH to 20 patients with Itsenko-Cushing disease and to 5 healthy persons. In healthy persons LHRH injection caused no significant changes in the level of plasma ACTH, cortisol and prolactin. Patients with Itsenko-Cushing disease who had a high basal level of corticotropin on the 30th min after i.v. LHRH injection demonstrated a significant increase in the hormone level. A response to LHRH injection was absent in patients with a normal basal level of corticotropin and in healthy persons. A statistically significant increase in cortisol concentration was noted on the 60th min after LHRH injection in some of the patients responding to LHRH by a high ACTH level. LHRH injection was not accompanied by significant changes in the level of plasma prolactin in either of the subgroups.
Manusharova
R A
RA
Cheban
A K
AK
Komissarenko
I V
IV
Slavnov
V N
VN
Veĭnberg
E G
EG
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D003480:Cushing Syndrome / Q000097:blood* / Q000188:drug therapy; D004341:Drug Evaluation; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007262:Infusions, Intravenous; D011388:Prolactin / Q000097:blood*; D013997:Time Factors
D007987:Gonadotropin-Releasing Hormone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D006854:Hydrocortisone
Dinamika soderzhaniia kortikotropina, kortizola i prolaktina v plazme krovi zhenshchin s bolezn'iu Itsenko-Kushinga pri vvedenii liuliberina.