title: Exercise hemodynamics and gas exchange in patients with chronic obstruction pulmonary disease, sleep desaturation, and a daytime PaO2 above 60 mm Hg.
abstract: Nocturnal oxyhemoglobin desaturation (NOD) has been reported in patients with disease of the pulmonary parenchyma and/or chest wall. The resulting hypoxemia could play a role in the development of pulmonary hypertension. We have previously demonstrated a small but statistically significant difference in resting pulmonary artery pressure (Ppa) and pulmonary vascular resistance (PVR) between two groups of patients with COPD of similar age, symptomatology, and degree of pulmonary dysfunction. These two groups were selected only on the basis of the presence or absence of NOD, and all had a mean daytime PaO2 at or above 60 mm Hg. The present study uses exercise to stress the pulmonary circulation of two groups of patients similar to the above. The purpose was to see if exercise can amplify underlying cardiopulmonary hemodynamic differences between NOD and non-NOD subjects. In addition, we attempted to confirm or refute previous studies which claimed that exercise desaturation correlates with NOD. Resting supine, resting upright, and upright exercise cardiopulmonary hemodynamics were measured using an indwelling right heart catheter, and arterial blood and expiratory gases were collected to assess metabolic and other gas exchange parameters. Although both groups showed increase in Ppa during exercise, the increases in systolic Ppa, mean Ppa, and driving pressure were disparately higher in subjects with NOD. Exercise desaturation was not predictive of NOD. The presence of NOD was predictive of a resting PVR greater than 120 dyne.s.cm-5, whereas mean sleep SaO2 and daytime PaO2 were unable to discriminate patients with COPD above or below this level.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, Houston Veterans Administration Medical Center 77211.
authors.forename: E C
authors.initials: EC
authors.lastname: Fletcher
authors.forename: R A
authors.initials: RA
authors.lastname: Luckett
authors.forename: T
authors.initials: T
authors.lastname: Miller
authors.forename: J G
authors.initials: JG
authors.lastname: Fletcher
mesh_terms: D001158:Arteries; D002940:Circadian Rhythm; D015444:Exercise; D006439:Hemodynamics; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D008173:Lung Diseases, Obstructive / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000032:analysis*; D010313:Partial Pressure; D011187:Posture; D011652:Pulmonary Circulation; D011659:Pulmonary Gas Exchange; D012146:Rest; D012890:Sleep / Q000502:physiology*; D014655:Vascular Resistance
chemical_list: D010108:Oxyhemoglobins; D010100:Oxygen