title: Circulating interferon in the guinea pig infected with the XJ, prototype Junin virus strain.
abstract: The interferon (IFN) induction capacity of the XJ prototype strain of Junín virus (JV) was investigated in the guinea pig model. Circulating alpha IFN was detected in 50% of the animals from days 2 to 9 postinfection (pi) and in 100% at day 11 pi, when all animals were in the premortem stage. Individual levels ranged from 20 to 1,280 guinea pig IFN units (GPIFNU)/ml. A correlation between XJ strain virulence and IFN titers was recorded. A possible role of IFN as a pathogenic factor in the outcome of the disease is discussed.
authors.affiliation: Instituto Nacional de Microbiología, Dr. C.G. Malbrán Departamento Virus, Buenos Aires, Argentina.
authors.forename: C B
authors.initials: CB
authors.lastname: Dejean
authors.forename: J R
authors.initials: JR
authors.lastname: Oubiña
authors.forename: G
authors.initials: G
authors.lastname: Carballal
authors.forename: A R
authors.initials: AR
authors.lastname: Teyssié
mesh_terms: D000818:Animals; D006477:Arenaviruses, New World; D006168:Guinea Pigs; D006478:Hemorrhagic Fever, American / Q000097:blood*; D007370:Interferon Type I / Q000097:blood*; D014766:Viremia / Q000097:blood
chemical_list: D007370:Interferon Type I