title: Time for phenytoin concentration to peak: consequences of first-order and zero-order absorption.
abstract: An increase in the time required to achieve the peak plasma concentration is observed following the oral administration of increasing doses of phenytoin. Zero-order absorption is the usual explanation for this observation. The presence of Michaelis-Menten elimination also increases the peak time when absorption is first order. The contribution of each of these mechanisms in vivo is unknown.
authors.affiliation: Division of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco 94143-0622.
authors.forename: D L
authors.initials: DL
authors.lastname: McCauley
authors.forename: T N
authors.initials: TN
authors.lastname: Tozer
authors.forename: M E
authors.initials: ME
authors.lastname: Winter
mesh_terms: D000284:Administration, Oral; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008954:Models, Biological; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D010672:Phenytoin