title: Superinfection with porcine cytomegalovirus initiating transplacental infection.
abstract: Four sows with circulating antibody were exposed to porcine cytomegalovirus. Virus was detected in 8 of 24 foetuses by immunofluorescence and/or virus isolation from 2 sows with low levels of antibody. In 6 of the infected foetuses, the virus was in capillary endothelium and macrophages of the lung, and was associated with interlobular oedema in 2 of these. Virus was also detected in the nasal mucosa, spleen and brain. The majority of the virus-positive foetuses were grossly normal.
authors.affiliation: Department of Microbiology and Parasitology, Royal Veterinary College, London, Gt. Britain.
authors.forename: N
authors.initials: N
authors.lastname: Edington
authors.forename: S
authors.initials: S
authors.lastname: Broad
authors.forename: A E
authors.initials: AE
authors.lastname: Wrathall
authors.forename: J T
authors.initials: JT
authors.lastname: Done
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000382:microbiology / Q000635:transmission / Q000662:veterinary*; D005260:Female; D005315:Fetal Diseases / Q000382:microbiology / Q000662:veterinary*; D005333:Fetus / Q000382:microbiology; D005455:Fluorescent Antibody Technique; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology / Q000635:transmission*
chemical_list: D000914:Antibodies, Viral