title: Neuropathological changes in early HIV-1 dementia.
abstract: Early pathological abnormalities in human immunodeficiency virus (HIV-1)-related dementia have not been well documented. We report a homosexual man with fatigue and intermittent diarrhea in whom early HIV-1-related dementia was demonstrated during neurological screening in the Multicenter AIDS Cohort Study. Within 4 months he died of massive epistaxis, and the brain revealed astrocytosis of white matter and mild pallor of myelin staining in the absence of inflammation, multinucleated giant cells, and brain atrophy.
authors.affiliation: Johns Hopkins Medical Institutions, Baltimore, MD.
authors.forename: J C
authors.initials: JC
authors.lastname: McArthur
authors.forename: P S
authors.initials: PS
authors.lastname: Becker
authors.forename: J E
authors.initials: JE
authors.lastname: Parisi
authors.forename: B
authors.initials: B
authors.lastname: Trapp
authors.forename: O A
authors.initials: OA
authors.lastname: Selnes
authors.forename: D R
authors.initials: DR
authors.lastname: Cornblath
authors.forename: J
authors.initials: J
authors.lastname: Balakrishnan
authors.forename: J W
authors.initials: JW
authors.lastname: Griffin
authors.forename: D
authors.initials: D
authors.lastname: Price
mesh_terms: D015526:AIDS Dementia Complex / Q000473:pathology*; D000328:Adult; D006801:Humans; D008297:Male