title: Incidence of cytomegalovirus infections in renal transplant patients treated with conventional or cyclosporin therapy.
abstract: The incidence and severity of cytomegalovirus (CMV) infection was examined in groups of consecutive renal transplant patients: group A (50 patients) transplanted from August 1984 to October 1985 received cyclosporin (from the day of transplantation) and steroid therapy; group B (50 patients) transplanted between June and July 1984 received conventional therapy (azathioprine and steroids, and antilymphocyte globulin for 14 days). In groups A and B there were respectively 5 (10%) and 14 (28%) seronegative patients prior to transplantation (CMV antibody titre less than 128 by ELISA); the overall incidence of CMV was 38% vs 74% (P less than 0.001); the incidence of primary infection was 0% (0 of 5) vs 36% (5 of 14) (NS); the incidence of secondary infection was 42% (19 of 45) vs 89% (32 of 36) (P less than 0.00001); and the total incidence of symptomatic infection was 10% vs 26% (P = 0.04). Thus we conclude that initial cyclosporin therapy leads to a reduction in CMV infection.
authors.affiliation: Service de Néphrologie, Hôpital Nord, CHRU St Etienne, France.
authors.forename: C
authors.initials: C
authors.lastname: Guerin
authors.forename: B
authors.initials: B
authors.lastname: Pozzetto
authors.forename: C
authors.initials: C
authors.lastname: Genin
authors.forename: F C
authors.initials: FC
authors.lastname: Berthoux
authors.forename: O G
authors.initials: OG
authors.lastname: Gaudin
mesh_terms: D000961:Antilymphocyte Serum / Q000009:adverse effects / Q000627:therapeutic use; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use; D003524:Cyclosporins / Q000009:adverse effects / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000453:epidemiology* / Q000209:etiology; D005602:France; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects* / Q000379:methods; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016030:Kidney Transplantation; D008775:Methylprednisolone / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000961:Antilymphocyte Serum; D003524:Cyclosporins; D007166:Immunosuppressive Agents; D001379:Azathioprine; D008775:Methylprednisolone