Age, menopausal status and DNA-content in endometrial adenocarcinoma.
In a prospective study of 283 women with endometrial carcinoma, 29 of whom were premenopausal and 254 postmenopausal, the DNA content and S-phase rate were measured by flow cytometry. Over 90% of the tumors in premenopausal women were peri-diploid and the remaining tumors were tetraploid, whereas 23% of the tumors in post-menopausal women were grossly aneuploid (p less than 0.01). Similar differences were found between women younger or older than 50 years. The results indicate that the hormonal status and/or age are of importance for the development of genetically different forms of endometrial carcinomas, as judged from the DNA-distribution.
Strang
P
P
Department of Oncology, Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden.
Stendahl
U
U
Tribukait
B
B
Wagenius
G
G
Boman
K
K
D000230:Adenocarcinoma / Q000032:analysis / Q000235:genetics / Q000473:pathology*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D009367:Neoplasm Staging; D011003:Ploidies; D014594:Uterine Neoplasms / Q000032:analysis / Q000235:genetics / Q000473:pathology*
D004273:DNA, Neoplasm