Relaxation and imaging of lithium in vivo.
It has recently been demonstrated that NMR imaging can be used to record the distribution of lithium. We now report on the parameters pertinent to this imaging. Specifically, the relaxation of Li in aqueous solution, in agarose gel, and in vivo has been investigated. In the latter case, both the longitudinal and transverse relaxations were biexponential, consistent with the behavior expected for a spin 3/2 quadrupole relaxed nucleus. The overall relaxation rate was quite slow in vivo with T'1 = 3.5 sec and T''1 = 6.6 sec.
Renshaw
P F
PF
Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104.
Haselgrove
J C
JC
Bolinger
L
L
Chance
B
B
Leigh
J S
JS
D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D002712:Chlorides / Q000493:pharmacokinetics*; D004285:Dogs; D008094:Lithium / Q000493:pharmacokinetics*; D018021:Lithium Chloride; D008279:Magnetic Resonance Imaging; D008961:Models, Structural; D014018:Tissue Distribution
D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride