Oxidative stress and lens opacity: an overall approach to screening anticataractous drugs.
Since oxidative stress is a well substantiated hypothesis of cataract pathogenesis, screening was performed in acellular systems in order to select scavengers of reactive oxygen species; the selected compounds are at present being tested in lens culture and in animal models.
Tissié
G
G
Centre de Recherche, Laboratoires Chauvin S.A., Montpellier, France.
Guillermet
V
V
Latour
E
E
Coquelet
C
C
Bonne
C
C
D000818:Animals; D000838:Anions / Q000378:metabolism; D002386:Cataract / Q000139:chemically induced / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals; D006878:Hydroxides / Q000378:metabolism; D007908:Lens, Crystalline / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D010545:Peroxides / Q000037:antagonists & inhibitors / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
D000838:Anions; D005609:Free Radicals; D006878:Hydroxides; D008081:Liposomes; D010545:Peroxides; D013481:Superoxides; D010100:Oxygen