[Combined action of nucleosides and alpha-interferon in inhibiting the reproduction of the herpes simplex type-II virus].
Therapeutic effect of four combinations of antiherpetic chemical preparations--acyclovir (ACV), 9-beta-D-arabinofuranosyladenine (ARA-A) and E-5-(2-bromovinyl)-2'-desoxyuridine (BVDU)--has been studied. Mutual enhancement was observed in all the combinations studied, except for ACV and ARA-A combination, where partial antagonism was observed. ACV + BVDU was shown to be the most optimal combination, with the minimum inhibitory concentration (MIC) of BVDU decreasing 400-fold. A significant enhancement of nucleosides antiviral effect was noted when the human leucocyte interferon was used with the combinations. Along with synergistic effect during the interaction of alpha-interferon with ACV the antagonism in the combination of alpha-interferon with ARA-A was observed.
Temicheva
E V
EV
Malinovskaia
V V
VV
Manakhova
L S
LS
Mironova
L L
LL
Galegov
G A
GA
D000212:Acyclovir / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives / Q000494:pharmacology; D003864:Depression, Chemical; D004357:Drug Synergism; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D009705:Nucleosides / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology; D014740:Vidarabine / Q000494:pharmacology; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D007370:Interferon Type I; D009705:Nucleosides; C020235:brivudine; D014740:Vidarabine; D001973:Bromodeoxyuridine; D000212:Acyclovir
Sochetannoe deĭstvie nekotorykh nukleozidov i al'fa-interferona pri ingibirovanii reproduktsii virusa prostogo gerpesa II tipa.