title: Noradrenergic modulation of olfactory bulb excitability in the postnatal rat.
abstract: Noradrenergic centrifugal inputs to the rat olfactory bulb mainly terminate on granule cells, which are inhibitory interneurons. In the mature bulb, norepinephrine suppresses granule cell activity, thus increasing the excitability of the primary output neurons of the bulb. However, since the majority of granule cells develop postnatally, the effectiveness of noradrenergic inputs to the bulb during development is unclear. The present report describes the postnatal development of noradrenergic modulation of olfactory bulb function by examining the effects of noradrenergic beta-receptor agonists and antagonists on paired-pulse inhibition at the granule cell/mitral cell reciprocal synapse. The results demonstrate that noradrenergic modulation of olfactory bulb excitability emerges during the first postnatal week in the rat. These results suggest that noradrenergic centrifugal control of olfactory bulb activity appears early during postnatal development, and thus is capable of playing an important role in pup responses to olfactory cues early in life.
authors.affiliation: Department of Psychobiology, University of California, Irvine 92717.
authors.forename: D A
authors.initials: DA
authors.lastname: Wilson
authors.forename: M
authors.initials: M
authors.lastname: Leon
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000375:Aging / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology / Q000502:physiology*; D009830:Olfactory Bulb / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*
chemical_list: D011941:Receptors, Adrenergic; D011433:Propranolol; D007545:Isoproterenol; D009638:Norepinephrine