title: Immunotoxicology: environmental contamination by polybrominated biphenyls and immune dysfunction among residents of the State of Michigan.
abstract: In 1973, inadvertent contamination occurred in a special farm feed supplement for lactating cows. Polybrominated biphenyls (PBBs) were used in place of magnesium oxide resulting in serious harm to farm animals, including cattle, chickens, geese, ducks. Farm families, accustomed to eating their own products, were most heavily exposed. To study the impact of PBBs, 336 adult Michigan farm residents, 117 general consumers for comparison, 75 dairy farm residents in Wisconsin, who had not eaten PBB-contaminated food, were examined, as were 79 healthy subjects in New York City. Abnormalities in the Michigan groups included hypergammaglobulinemia, exaggerated hypersensitive response to streptococci, significant decrease in absolute numbers and percentage of T and B-lymphocytes, and increased number of lymphocytes with no detectable surface markers ("null cells"). Significant reduction of in vitro immune function was noted in 20-25% of the Michigan farm residents who had eaten food containing PBB. The decreased immune function detected among the PBB-exposed farm residents tended to affect families as a unit and was independent of exposed individuals' age or sex, pointing against the possibility of genetic predisposition.
authors.affiliation: Department of Neoplastic Diseases, Mount Sinai School of Medicine of the City University of New York, NY 10029.
authors.forename: J G
authors.initials: JG
authors.lastname: Bekesi
authors.forename: J P
authors.initials: JP
authors.lastname: Roboz
authors.forename: A
authors.initials: A
authors.lastname: Fischbein
authors.forename: P
authors.initials: P
authors.lastname: Mason
mesh_terms: D000382:Agricultural Workers' Diseases / Q000209:etiology / Q000276:immunology*; D000818:Animals; D004787:Environmental Pollution; D006801:Humans; D007154:Immune System Diseases / Q000209:etiology*; D008824:Michigan; D011075:Polybrominated Biphenyls / Q000009:adverse effects* / Q000633:toxicity
chemical_list: D011075:Polybrominated Biphenyls