title: Discordance between the cortisol response to insulin-hypoglycemia and 30-minute ACTH stimulation test in chronic alcoholic men.
abstract: An insulin hypoglycemia test and a 30-min ACTH stimulation test was performed in 10 chronic alcoholic men, who had been abstinent from alcohol for at least one month. Attenuated serum cortisol responses were found in six of the patients despite a normal ACTH test. Four patients showed normal responses to both the insulin hypoglycemia test and the short ACTH test. No correlation was demonstrated between the cortisol response and the severity of alcoholism, cerebral atrophy, and peripheral neuropathy. It is concluded that in chronic alcoholism the short ACTH test may fail in disclosing hypofunction of the integrated hypothalamic-pituitary-adrenocortical (HPA) axis as assessed with the insulin hypoglycemia test.
authors.forename: G M
authors.initials: GM
authors.lastname: Knudsen
authors.forename: H
authors.initials: H
authors.lastname: Christensen
authors.forename: D
authors.initials: D
authors.lastname: Berild
authors.forename: B
authors.initials: B
authors.lastname: Melgaard
authors.forename: C
authors.initials: C
authors.lastname: Kirkegaard
authors.forename: H
authors.initials: H
authors.lastname: Hasselbalch
mesh_terms: D000324:Adrenocorticotropic Hormone; D000328:Adult; D000437:Alcoholism / Q000097:blood* / Q000503:physiopathology; D001786:Blood Glucose / Q000032:analysis; D003366:Cosyntropin; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007003:Hypoglycemia / Q000139:chemically induced* / Q000503:physiopathology; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007328:Insulin; D008297:Male; D008875:Middle Aged; D010912:Pituitary-Adrenal Function Tests
chemical_list: D001786:Blood Glucose; D007328:Insulin; D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone