Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioral findings.
Six of eight patients with obsessive-compulsive disorder had an exacerbation of symptoms when given m-chlorophenylpiperazine. Fenfluramine and placebo produced mild improvement. Six patients given intravenous clonidine experienced marked reduction in obsessions. Implications for serotonergic and noradrenergic hypotheses of obsessive-compulsive disorder are discussed.
Hollander
E
E
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032.
Fay
M
M
Cohen
B
B
Campeas
R
R
Gorman
J M
JM
Liebowitz
M R
MR
D000328:Adult; D003000:Clonidine / Q000494:pharmacology; D005277:Fenfluramine / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D010879:Piperazines / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology*
D010879:Piperazines; D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin; D005277:Fenfluramine; D003000:Clonidine; C015068:1-(3-chlorophenyl)piperazine