title: Tacaribe virus infection may induce inhibition of the activity of the host cell Ca2+ and Na+/K+ pumps.
abstract: Infection of Vero cells with Tacaribe virus stocks containing a high ratio of standard (plaque-forming) viruses to defective interfering particles (DIP) induced inhibition of the host cell Ca2+ ATPase (Ca2+ pump) and the ouabain-sensitive Na+/K+ ATPase (Na+/K+ pump). The Mg2+ ATPase which is not involved in cation transport was not affected. The presence of DIP in the inocula protected the cells from alteration of the transport-associated ATPases induced by standard viruses.
authors.affiliation: Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina.
authors.forename: O
authors.initials: O
authors.lastname: Rey
authors.forename: J P
authors.initials: JP
authors.lastname: Rossi
authors.forename: R
authors.initials: R
authors.lastname: López
authors.forename: S J
authors.initials: SJ
authors.lastname: Iapalucci-Espinoza
authors.forename: M T
authors.initials: MT
authors.lastname: Franze-Fernández
mesh_terms: D000818:Animals; D001116:Arenaviridae / Q000502:physiology*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D003673:Defective Viruses / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D014709:Vero Cells; D014779:Virus Replication
chemical_list: D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase