Nuclear factor 1 (NF-1) binding sites in the genomes of human oncoviruses: a hypothetic role for reintegrated cellular origins of replication in malignant transformation.
We have found that genomes of human T cell leukemia-lymphoma virus type I (HTLV-I), BK virus (BKV), and a hepatitis B virus (HBV) DNA sequence integrated into DNA of a hepatoma-derived cell line contain binding sites for nuclear factor 1 (NF-1), a cellular protein which binds to adenoviral and putative cellular origins of DNA replication. We suggest that cellular origins of DNA replication acquired by oncoviruses may play a role in malignant transformation after reintegration into the cellular genome by providing new targets for cellular factors initiating DNA replication and by perturbing the temporal order of replication.
Minarovits
J
J
Microbiological Research Group, National Institute of Hygiene, Budapest, Hungary.
Segesdi
J
J
Kovacs
Z
Z
Földes
I
I
D001665:Binding Sites; D022762:CCAAT-Enhancer-Binding Proteins; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism*; D004261:DNA Replication; D004279:DNA, Viral / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D017977:Deltaretrovirus / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D051839:NFI Transcription Factors; D009687:Nuclear Proteins; D009858:Oncogenic Viruses / Q000235:genetics*; D027383:Papillomaviridae / Q000235:genetics; D027382:Polyomaviridae; D012689:Sequence Homology, Nucleic Acid; D014157:Transcription Factors; D051840:Y-Box-Binding Protein 1
D022762:CCAAT-Enhancer-Binding Proteins; D004279:DNA, Viral; D004268:DNA-Binding Proteins; D051839:NFI Transcription Factors; D009687:Nuclear Proteins; D014157:Transcription Factors; D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human