Pregnancy induced hypertension: will treatment with dietary eicosapentaenoic acid be effective?
The current understanding of endothelial membrane prostaglandin metabolism is presented together with an explanation of how this may be altered in pregnancy induced hypertension (PIH). A hypothesis is proposed to explain why dietary supplementation with eicosapentaenoic acid (EPA) may reverse abnormal prostaglandin metabolism, increase membrane fluidity and lower blood pressure in PIH.
England
M J
MJ
Department of Obstetrics and Gynaecology, University of the Witwatersrand, Johannesburg Hospital, Parktown, South Africa.
Atkinson
P M
PM
Sonnendecker
E W
EW
D015118:Eicosapentaenoic Acid / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000178:diet therapy* / Q000378:metabolism; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000178:diet therapy* / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism
D011453:Prostaglandins; D015118:Eicosapentaenoic Acid