Interleukin-1 inhibits follicle stimulating hormone-induced differentiation in rat granulosa cells in vitro.
Increasing evidence suggests that factors secreted from cells of the immune system can affect endocrine function. In this report we show that the monokine, interleukin-1, inhibits follicle stimulating hormone-induced development of luteinizing hormone receptors and reduces progesterone secreted from cultured rat granulosa cells. These effects of interleukin-1 were observed in the physiological range of 10(-9) M. The ability of sex steroids to influence the immune response together with our results support the hypothesis that there is a bidirectional communication network which links the immune and reproductive endocrine systems.
Gottschall
P E
PE
U.S.-Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, Louisisana 70037.
Uehara
A
A
Hoffmann
S T
ST
Arimura
A
A
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D006107:Granulosa Cells / Q000166:cytology / Q000187:drug effects*; D007375:Interleukin-1 / Q000494:pharmacology*; D011374:Progesterone / Q000378:metabolism; D051381:Rats; D011974:Receptors, LH / Q000096:biosynthesis
D007375:Interleukin-1; D011974:Receptors, LH; D011374:Progesterone; D000324:Adrenocorticotropic Hormone; D005640:Follicle Stimulating Hormone