[Complex pathogenetic therapy of experimental botulism].
The study of survival and life span of mice and white rats upon the administration of LD50 of the toxin has shown that an antihypoxic agent--gutimine (50-200 mg/kg)--had a protecting effect in type C botulinum intoxication. A combined use of gutimine and 4-aminopyridine (1-5 mg/kg), facilitating a transmitter release in synapses, had a more marked protecting effect in botulinum intoxication. Due to the potentiation of the drugs effect during their combined application, the doses of each drug in the combination could be reduced.
Kryzhanovskiĭ
G N
GN
Morrison
V V
VV
D015761:4-Aminopyridine; D000631:Aminopyridines / Q000008:administration & dosage* / Q000627:therapeutic use; D000818:Animals; D001906:Botulism / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006164:Guanylthiourea / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D013890:Thiourea / Q000031:analogs & derivatives*
D000631:Aminopyridines; D015761:4-Aminopyridine; D013890:Thiourea; D006164:Guanylthiourea
Kompleksnaia patogeneticheskaia terapiia pri éksperimental'noĭ botulinicheskoĭ intoksikatsii.