title: Cyclic GMP phosphodiesterase from bovine retina. Amino acid sequence of the alpha-subunit and nucleotide sequence of the corresponding cDNA.
abstract: The alpha-subunit primary structure of cyclic GMP phosphodiesterase has been determined by parallel analysis of the protein amino acid sequence and the corresponding cDNA nucleotide sequence. The enzyme alpha-subunit contains 858 amino acid residues, its N-terminal amino group being acetylated. The partial primary structure of the enzyme beta-subunit has also been elucidated. A significant homology has been found between the alpha- and beta-subunits of cGMP phosphodiesterase.
authors.affiliation: Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, Moscow.
authors.lastname: Ovchinnikov YuA
authors.forename: V V
authors.initials: VV
authors.lastname: Gubanov
authors.forename: N V
authors.initials: NV
authors.lastname: Khramtsov
authors.forename: K A
authors.initials: KA
authors.lastname: Ischenko
authors.forename: V E
authors.initials: VE
authors.lastname: Zagranichny
authors.forename: K G
authors.initials: KG
authors.lastname: Muradov
authors.forename: T M
authors.initials: TM
authors.lastname: Shuvaeva
authors.forename: V M
authors.initials: VM
authors.lastname: Lipkin
mesh_terms: D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D008969:Molecular Sequence Data; D010442:Peptide Chain Initiation, Translational; D012160:Retina / Q000201:enzymology*
chemical_list: D004247:DNA; D015106:3',5'-Cyclic-GMP Phosphodiesterases