title: Oxidative stress and lens opacity: an overall approach to screening anticataractous drugs.
abstract: Since oxidative stress is a well substantiated hypothesis of cataract pathogenesis, screening was performed in acellular systems in order to select scavengers of reactive oxygen species; the selected compounds are at present being tested in lens culture and in animal models.
authors.affiliation: Centre de Recherche, Laboratoires Chauvin S.A., Montpellier, France.
authors.forename: G
authors.initials: G
authors.lastname: Tissié
authors.forename: V
authors.initials: V
authors.lastname: Guillermet
authors.forename: E
authors.initials: E
authors.lastname: Latour
authors.forename: C
authors.initials: C
authors.lastname: Coquelet
authors.forename: C
authors.initials: C
authors.lastname: Bonne
mesh_terms: D000818:Animals; D000838:Anions / Q000378:metabolism; D002386:Cataract / Q000139:chemically induced / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals; D006878:Hydroxides / Q000378:metabolism; D007908:Lens, Crystalline / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D010545:Peroxides / Q000037:antagonists & inhibitors / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
chemical_list: D000838:Anions; D005609:Free Radicals; D006878:Hydroxides; D008081:Liposomes; D010545:Peroxides; D013481:Superoxides; D010100:Oxygen