title: Effect of the recombinant vaccinia viruses that express HTLV-I envelope gene on HTLV-I infection.
abstract: The human T-lymphotropic virus type I (HTLV-I) is etiologically linked to adult T-cell leukemia (ATL). To develop a vaccine against ATL, we constructed recombinant vaccinia viruses containing the envelope gene of HTLV-I in the vaccinia virus hemagglutinin (HA) gene, a new site where foreign genes can be inserted. A single inoculation of the recombinant virus induced antibodies to the env proteins of HTLV-I in rabbits and had a protective effect against HTLV-I infection.
authors.affiliation: Institute for Virus Research, Kyoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Shida
authors.forename: T
authors.initials: T
authors.lastname: Tochikura
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Konno
authors.forename: K
authors.initials: K
authors.lastname: Hirayoshi
authors.forename: M
authors.initials: M
authors.lastname: Seki
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Hatanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Hinuma
authors.forename: M
authors.initials: M
authors.lastname: Sugimoto
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis / Q000235:genetics; D002460:Cell Line; D017977:Deltaretrovirus / Q000235:genetics*; D005796:Genes; D005814:Genes, Viral; D005822:Genetic Vectors; D010957:Plasmids; D011401:Promoter Regions, Genetic; D011817:Rabbits; D011995:Recombination, Genetic; D014616:Vaccinia virus / Q000235:genetics*; D014759:Viral Envelope Proteins / Q000235:genetics*
chemical_list: D000956:Antigens, Viral; D014759:Viral Envelope Proteins