title: Alloantibodies, autoantibodies, and immune complexes in patients with lung cancer.
abstract: The sera of patients with lung cancer, nonmalignant lung disease, and blood donors were subjected to various immunologic assays. Nine assays, based on immunoradiometric (IRMA) and immunoenzymatic (ELISA) principles, included 3 types of fetal cell antibodies, 2 established lung cancer cell antibodies, anti-DNA, anti-IgG autoantibodies, and immune complex assays based on C1q binding and anti-C3 activity. Antitumor cell antibody level was significantly lower in patients with lung cancer compared to blood donors. In the remaining 7 assays, the lung cancer patients tended towards higher median values compared to both control patients and blood donors, but without statistical significance, with the exception of anti-DNA antibodies. Statistical analysis of all 9 assays taken together has shown significant differences between the 3 groups. When only 5 assays were used to assess 3 types of fetal cell antibodies, anti-DNA antibodies, and immune complexes by means of ELISA anti-C3, the margins between groups increased. A range of values for the selected assays was established that may discriminate 70% of tested individuals of the 3 groups. These results suggest the existence of a characteristic profile of deranged humoral immunity in lung cancer patients.
authors.affiliation: Department of Clinical Pathomorphology, Academy of Medicine, Poznań, Poland.
authors.forename: M K
authors.initials: MK
authors.lastname: Górny
authors.forename: M
authors.initials: M
authors.lastname: Lawniczak
authors.forename: R
authors.initials: R
authors.lastname: Jenek
authors.forename: A
authors.initials: A
authors.lastname: Słowik-Gabryelska
authors.forename: E
authors.initials: E
authors.lastname: Kaczmarek
authors.forename: J
authors.initials: J
authors.lastname: Zeromski
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology; D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis* / Q000276:immunology; D000912:Antibodies, Neoplasm / Q000032:analysis* / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000032:analysis* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology; D018288:Carcinoma, Small Cell / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000276:immunology; D004273:DNA, Neoplasm / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007518:Isoantibodies / Q000032:analysis* / Q000276:immunology; D008175:Lung Neoplasms / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000912:Antibodies, Neoplasm; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D004273:DNA, Neoplasm; D007074:Immunoglobulin G; D007518:Isoantibodies