Regulation of mouse trophoblast giant cell nucleus development in hatched mouse blastocysts by cyclic cytidine 3',5'-monophosphate (cCMP).
The dibutyryl analog of cCMP enlarged the nuclei of trophoblast giant cells and promoted blastocyst development. The result suggests that cCMP has a trophic effect on embryonic development, specifically by altering the size of the trophoblast cell nucleus but does not enhance trophoblast cell proliferation processes.
Chan
P J
PJ
Department of Obstetrics and Gynecology, Oral Roberts University School of Medicine, Tulsa, Oklahoma 74104.
Henig
I
I
Tredway
D R
DR
D000818:Animals; D001755:Blastocyst / Q000502:physiology* / Q000648:ultrastructure; D002448:Cell Adhesion; D002455:Cell Division; D002467:Cell Nucleus / Q000648:ultrastructure; D046508:Culture Techniques; D003563:Cyclic CMP / Q000494:pharmacology*; D003597:Cytosine Nucleotides / Q000494:pharmacology*; D051379:Mice; D014327:Trophoblasts / Q000648:ultrastructure*
D003597:Cytosine Nucleotides; D003563:Cyclic CMP