Intravenous administration mode for lead inclusion development in mouse tissues.
B6CF1 mice were injected with a 80 mg lead (Pb)/kg. One week later, the liver retained about 0.13 mg Pb/g or 9.8 +/- 1.5% of the injected dose (ID)/g fresh weight (mean +/- SE, n = 4). This level decreased to 3.9 +/- 0.6% ID/g (n = 5) after 2 weeks. Intranuclear Pb inclusions averaging 1.6 +/- 0.1 micron in diameter (n = 10) were present within parenchymal hepatocytes. Intravenous (i.v.) injections of 2.6 microCi were adequate for autoradiographic localization of Pb deposits within the liver. One week after Pb injection, most tracts were present over endothelial lining cells of the hepatic sinusoids; however, Pb, deposited within intranuclear inclusions of parenchymal hepatocytes was inadequate for tract development. Therefore, i.v. administration of 80 mg/kg Pb resulted in the formation of inclusions within nuclei of parenchymal hepatocytes of B6CF1 mice.
Sorensen
E M
EM
College of Pharmacy, Department of Pharmacology/Toxicology, University of Texas, Austin 78712.
Bhattacharyya
M H
MH
D000818:Animals; D001822:Body Burden; D005260:Female; D002479:Inclusion Bodies / Q000378:metabolism*; D007275:Injections, Intravenous; D007854:Lead / Q000008:administration & dosage / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D051379:Mice
D007854:Lead