[Immunomodulating properties of salmozan and its effect on the functional activity of macrophages].
The effect of salmozan on the resistance of mice to Listeria monocytogenes infection, the formation of delayed hypersensitivity (DH) to sheep red blood cells in the animals, as well as changes in some functional activity characteristics of macrophages have been studied. The study has revealed that salmozan enhances anti-infectious resistance, suppresses the dermal manifestations of DH, and decreases the level of 5'-nucleotidase in peritoneal macrophages, stimulating their phagocytic activity. The intensity of the drug action depends on the time of its administration. The most pronounced immunomodulating action and maximal changes in the function of macrophages have been registered simultaneously after the treatment of the animals with salmozan.
Tumanian
M A
MA
Mysiakin
E B
EB
Duplishcheva
A P
AP
Zaĭtseva
L G
LG
Sinilova
N G
NG
D015720:5'-Nucleotidase; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D006968:Hypersensitivity, Delayed / Q000276:immunology / Q000517:prevention & control; D008088:Listeriosis / Q000276:immunology / Q000517:prevention & control; D008211:Lymphocyte Cooperation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009708:Nucleotidases / Q000032:analysis; D010587:Phagocytosis / Q000187:drug effects; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D012485:Salmonella typhi; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D011135:Polysaccharides, Bacterial; C029023:salmozan; D009708:Nucleotidases; D015720:5'-Nucleotidase
Immunomoduliruiushchie svoĭstva sal'mozana i ego vliianie na funktsional'nuiu aktivnost' makrofaga.