title: Late asthmatic reactions and changes in histamine responsiveness provoked by occupational agents.
abstract: The temporal and quantitative relationship between increases in airway responsiveness and late asthmatic reactions provoked by inhalation challenge with occupational agents was studied in nine individuals who underwent a total of thirteen active inhalation challenge tests with one of the following agents: toluene diisocyanate (TDI), maleic anhydride (MA), trimellitic anhydride (TMA), carmine, or colophony (pine wood resin). Airway responsiveness to inhaled histamine (histamine PC20) was measured before and at approximately 3 and 24 h after control and active challenge exposure, when, on all but four occasions, FEV1 was within 10% of pre-challenge values. Significant increases (p less than 0.02) in histamine responsiveness were present at 3 h following challenge exposures which subsequently provoked a definite late asthmatic reaction (FEV1 decrease greater than 15% 3-11 h post challenge). These increases in histamine responsiveness were significantly greater than those at 3 h following the challenges which provoked an isolated early (FEV1 decrease less than 6% 3-11 h post-challenge) or equivocal late asthmatic reaction (FEV1 decrease 6-15% 3-11 h post-challenge) (p less than 0.03). Although histamine responsiveness remained high at 24 h after challenges provoking late asthmatic reactions (p less than 0.05), this was less than the increase at 3 h and not significantly different from the PC20 at 24 h after challenges provoking either single early or equivocal late asthmatic reactions.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: John Radcliffe Hospital, Headington, Oxford, UK.
authors.forename: B J
authors.initials: BJ
authors.lastname: Graneek
authors.forename: S R
authors.initials: SR
authors.lastname: Durham
authors.forename: A J
authors.initials: AJ
authors.lastname: Newman Taylor
mesh_terms: D001249:Asthma / Q000139:chemically induced* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D005541:Forced Expiratory Volume; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D008299:Maleic Anhydrides / Q000009:adverse effects; D009784:Occupational Diseases / Q000139:chemically induced* / Q000503:physiopathology; D010796:Phthalic Anhydrides / Q000009:adverse effects; D012123:Pulmonary Ventilation / Q000187:drug effects*; D012116:Resins, Plant / Q000009:adverse effects; D013638:Tars / Q000009:adverse effects; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects
chemical_list: D008299:Maleic Anhydrides; D010796:Phthalic Anhydrides; D012116:Resins, Plant; D013638:Tars; D014051:Toluene 2,4-Diisocyanate; C015559:trimellitic anhydride; D006632:Histamine; C013893:rosin