title: Atrial natriuretic peptide administration to normal and salt depleted rats--effects on digoxin-like immunoreactive factor, aldosterone, ACTH, and renal function.
abstract: In view of the known interrelationships between renin, aldosterone, and atrial natriuretic peptide (ANP), we sought to examine whether there also exists an interaction between ANP and digoxin-like immunoreactive factor (DLIF). We therefore studied the effects of ANP administration on normal and salt-depleted rats, and measured the effects on blood pressure, urine output, glomerular filtration rate, sodium excretion, aldosterone, ACTH, and DLIF levels. ANP administration resulted in a significant elevation of sodium excretion and glomerular filtration rate and a fall in blood pressure. DLIF concentrations in plasma rose significantly, as did urinary DLIF excretion. ANP administration resulted in a fall in aldosterone as well as ACTH. These observations suggest that ANP has a direct inhibitory effect on ACTH secretion. Our findings support the concept of an interrelationship between ANP and DLIF.
authors.affiliation: Department of Medicine C, Meir Hospital, Sapir Medical Center, Kfar Saba, Israel.
authors.forename: L
authors.initials: L
authors.lastname: Shilo
authors.forename: A
authors.initials: A
authors.lastname: Pomeranz
authors.forename: M
authors.initials: M
authors.lastname: Rathaus
authors.forename: E
authors.initials: E
authors.lastname: Weiss
authors.forename: J
authors.initials: J
authors.lastname: Bernheim
authors.forename: L
authors.initials: L
authors.lastname: Shenkman
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000450:Aldosterone / Q000097:blood*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism* / Q000652:urine; D002298:Cardenolides; D004077:Digoxin; D004231:Diuresis / Q000187:drug effects; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D009318:Natriuresis / Q000187:drug effects; D051381:Rats; D012503:Saponins
chemical_list: D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D000450:Aldosterone; D004077:Digoxin; D009320:Atrial Natriuretic Factor; D000324:Adrenocorticotropic Hormone