In vitro activity of LY146032 alone and in combination with other antibiotics against gram-positive bacteria.
The antibacterial activity of LY146032 alone and in combination with other drugs was assayed against gram-positive isolates. Synergism was found when LY146032 was combined with netilmicin, amikacin, imipenem, and fosfomycin by both checkerboard and time-kill tests. Indifference predominated when LY146032 was combined with teicoplanin, vancomycin, and rifampin. Under no circumstances and with no combinations was an antagonistic effect detected.
Debbia
E
E
Institute of Microbiology, Medical School, University of Genoa, Italy.
Pesce
A
A
Schito
G C
GC
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017576:Daptomycin; D004347:Drug Interactions; D004357:Drug Synergism; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010455:Peptides; D017576:Daptomycin