title: In vitro activities of azithromycin (CP 62,993), clarithromycin (A-56268; TE-031), erythromycin, roxithromycin, and clindamycin.
abstract: The in vitro activity of azithromycin (CP 62,993 or XZ-450) against Haemophilus influenzae was greater than that of three other macrolides. However, azithromycin was four- to eightfold less active than erythromycin against the gram-positive cocci and against Listeria monocytogenes. Erythromycin and azithromycin were similar in their activity against Legionella pneumophila, Neisseria gonorrhoeae, Neisseria meningitidis, and Branhamella catarrhalis.
authors.affiliation: Clinical Microbiology Institute, Tualatin, Oregon 97062.
authors.forename: A L
authors.initials: AL
authors.lastname: Barry
authors.forename: R N
authors.initials: RN
authors.lastname: Jones
authors.forename: C
authors.initials: C
authors.lastname: Thornsberry
mesh_terms: D017963:Azithromycin; D001419:Bacteria / Q000187:drug effects*; D017291:Clarithromycin; D002981:Clindamycin / Q000494:pharmacology*; D003470:Culture Media; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000031:analogs & derivatives / Q000494:pharmacology*; D006193:Haemophilus influenzae / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007933:Leucomycins / Q000494:pharmacology
chemical_list: D003470:Culture Media; D007933:Leucomycins; D002981:Clindamycin; D004917:Erythromycin; D017963:Azithromycin; D017291:Clarithromycin