Progression of dermatofibrosarcoma protuberans to malignant fibrous histiocytoma: report of a case with implications for tumor histogenesis.
A 79-year-old woman required amputation of her left leg for the control of a rapidly growing malignant fibrous histiocytoma. This tumor had developed at the precise site of repeated recurrence of a previously diagnosed dermatofibrosarcoma protuberans. Biopsy specimens from the recurrences revealed a gradual change in appearance from dermatofibrosarcoma protuberans to malignant fibrous histiocytoma.
O'Dowd
J
J
Department of Pathology, University of Wales College of Medicine, Cardiff, United Kingdom.
Laidler
P
P
D000368:Aged; D001706:Biopsy; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology*; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009364:Neoplasm Recurrence, Local