Effect of clonidine on adrenal medulla catecholamine levels in rats.
The effects of clonidine on adrenal medulla catecholamines levels were studied in normotensive rats. Intraperitoneal injections (50,100 micrograms/kg) of clonidine caused a dose-dependent decrease in adrenaline content of the gland. This effect was suppressed by denervation of the adrenal medulla, i.e. unilateral section of splanchnic fibers performed 5 days before. These results demonstrate that clonidine decreases the catecholamine content of the adrenal medulla only through a central action. They suggest that the adrenal medulla is involved in the hypotensive effect of clonidine.
Gaillard
G
G
Laboratoire de Pharmacologie Médicale et Clinique (UA 644 du CNRS), Toulouse, France.
Tran
M A
MA
Rostin
M
M
Salvayre
R
R
Montastruc
J L
JL
D000313:Adrenal Medulla / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D003000:Clonidine / Q000494:pharmacology*; D003714:Denervation; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism
D002395:Catecholamines; D011942:Receptors, Adrenergic, alpha; D003000:Clonidine