Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on Epstein-Barr virus (EBV)-infected cells.
We have examined if 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances soft agar clonability in Epstein-Barr virus (EBV)-infected cells on the basis of interaction between EBV and TPA. When primary human cord blood lymphocytes (HUCLs) were exposed to two different strains of EBV (B95-8 and NPC-KT) and seeded in soft agar medium containing TPA (0.25 ng/ml), it was observed that the number of transformed colonies increased. However, TPA did not enhance the number of colonies in two EBV genome-positive epithelial hybrid cell lines (NPC-KT and D98/HR-1).
Takimoto
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Ishikawa
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Miyazaki
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D002460:Cell Line; D003043:Cocarcinogenesis; D004854:Herpesvirus 4, Human; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000209:etiology*; D013755:Tetradecanoylphorbol Acetate / Q000009:adverse effects*; D014412:Tumor Virus Infections / Q000209:etiology*
D013755:Tetradecanoylphorbol Acetate