[Establishment of a T lymphoid cell line producing a retrovirus of HTLV-I type, from peripheral blood of a patient with tropical spastic paraparesis].
HTLV-I, the causative agent of Adult T cell Leukemia, has recently been found to be associated with chronic neuromyelopathies common in tropical areas and in Japan. We report here the establishment of a lymphoid T cell line from peripheral blood lymphocytes of a patient with Tropical Spastic Paraparesis. This cell line produces a retrovirus whose morphologic, antigenic and genetic characteristics show no detectable difference from the leukemogenic prototype of HTLV-I.
Gessain
A
A
Institut de Recherches sur les Maladies du Sang, Laboratoire de Virologie des Leucémies, L.O.I.-C.N.R.S., Hôpital Saint-Louis, Paris.
Saal
F
F
Vilette
D
D
Lasneret
J
J
Giron
M L
ML
Sigaux
F
F
Gout
O
O
Emanoil-Ravier
R
R
de Thé
G
G
Periés
J
J
D000957:Antigens, Viral, Tumor / Q000032:analysis; D002460:Cell Line; D004279:DNA, Viral / Q000032:analysis; D017977:Deltaretrovirus / Q000235:genetics / Q000254:growth & development* / Q000276:immunology; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D009128:Muscle Spasticity / Q000097:blood; D010243:Paralysis / Q000097:blood*; D013601:T-Lymphocytes / Q000382:microbiology* / Q000473:pathology / Q000648:ultrastructure
D000957:Antigens, Viral, Tumor; D004279:DNA, Viral
Etablissement d'une lignée lymphoïde T productrice d'un rétrovirus de type HTLV-I à partir du sang périphérique d'un patient atteint de paraparésie spastique tropicale.