title: (+)-Curcuphenol and dehydrocurcuphenol, novel sesquiterpenes which inhibit H,K-ATPase, from a marine sponge Epipolasis sp.
abstract: Two H,K-ATPase inhibitors and an inactive related compound have been isolated from a marine sponge Epipolasis sp. They are aromatic sesquiterpene alpha-curcumenes.
authors.affiliation: Laboratory of Marine Biochemistry, Faculty of Agriculture, University of Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Fusetani
authors.forename: M
authors.initials: M
authors.lastname: Sugano
authors.forename: S
authors.initials: S
authors.lastname: Matsunaga
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects; D017506:H(+)-K(+)-Exchanging ATPase; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000032:analysis*; D051381:Rats; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D013270:Stomach / Q000201:enzymology
chemical_list: D012717:Sesquiterpenes; C054390:8,9-dehydrocurcuphenol; C054389:curcuphenol; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase