title: Novel molecules that antagonize leukotriene B4 binding to neutrophils.
abstract: A series of LTB4 analogues have been synthesized that replace carbons 7-9 of the cis-trans-trans triene unit of LTB4 with a stable ring structure. Meta-substituted pyridine analogues are more potent inhibitors than benzene or furan analogues. C-1 alcohols are often more potent inhibitors than free carboxylic acids, and 5,6-cis double bond compounds are more potent than 5,6-trans compounds. Compounds such as these may prove to be useful in the treatment of inflammatory diseases.
authors.affiliation: Cell Biology and Metabolic Diseases Research, Upjohn Company, Kalamazoo, Michigan 49001.
authors.forename: A H
authors.initials: AH
authors.lastname: Lin
authors.forename: J
authors.initials: J
authors.lastname: Morris
authors.forename: D G
authors.initials: DG
authors.lastname: Wishka
authors.forename: R R
authors.initials: RR
authors.lastname: Gorman
mesh_terms: D007975:Leukotriene B4 / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D011485:Protein Binding; D011971:Receptors, Immunologic / Q000187:drug effects* / Q000378:metabolism; D018102:Receptors, Leukotriene B4; D013329:Structure-Activity Relationship
chemical_list: D011971:Receptors, Immunologic; D018102:Receptors, Leukotriene B4; D007975:Leukotriene B4