Clinical problems of invasive hydatidiform mole in patients aged 40 or more.
Seventy-six patients with invasive hydatidiform mole (HM) were reviewed as to clinical course, particularly treatment and outcome, in relation to their age. The results were as follows: (i) metastatic cases showed approximately a twofold increase in patients over 40 compared with younger patients, (ii) more courses of chemotherapy were required to achieve a cure in patients over 40 than in younger patients and (iii) 4 of 19 patients (21.1%) over 40 developed choriocarcinoma, whereas none of younger patients did.
Kanazawa
K
K
Department of Obstetrics and Gynecology, School of Medicine, Niigata University, Japan.
Suzuki
T
T
Sasagawa
M
M
Takeuchi
S
S
D000328:Adult; D002822:Choriocarcinoma / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D002820:Hydatidiform Mole, Invasive / Q000175:diagnosis / Q000556:secondary / Q000628:therapy*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*