title: Metabolic effects of a low-glycemic-index diet.
abstract: Six healthy male volunteers underwent 2-wk metabolically controlled high-glycemic-index (GI) and low-GI diets in random order. Over the low-GI diet significant reductions were seen in serum fructosamine (7.0 +/- 1.0%, p less than 0.01), 12-h blood glucose profile (37 +/- 7%, p less than 0.01), and total serum cholesterol (15 +/- 3%, p less than 0.01). As a measure of insulin secretion, 24-h urinary C-peptide levels were 32 +/- 10% lower (p less than 0.05) after the low-GI than after the high-GI diet. Lower C-peptide levels were maintained after a standard carbohydrate challenge after the low-GI diet despite higher blood glucose levels. Differences in blood glucose were not seen after a 5-g intravenous glucose challenge. These results are of interest with respect to the effect that prolonged postprandial reductions in nutrient fluxes and insulin secretion may have on carbohydrate and lipid metabolism and renal function.
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada.
authors.forename: D J
authors.initials: DJ
authors.lastname: Jenkins
authors.forename: T M
authors.initials: TM
authors.lastname: Wolever
authors.forename: G R
authors.initials: GR
authors.lastname: Collier
authors.forename: A
authors.initials: A
authors.lastname: Ocana
authors.forename: A V
authors.initials: AV
authors.lastname: Rao
authors.forename: G
authors.initials: G
authors.lastname: Buckley
authors.forename: Y
authors.initials: Y
authors.lastname: Lam
authors.forename: A
authors.initials: A
authors.lastname: Mayer
authors.forename: L U
authors.initials: LU
authors.lastname: Thompson
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002096:C-Peptide / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004043:Dietary Fiber / Q000008:administration & dosage; D019270:Fructosamine; D006595:Hexosamines / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D014508:Urea / Q000097:blood
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D004040:Dietary Carbohydrates; D004043:Dietary Fiber; D006595:Hexosamines; D007328:Insulin; D008055:Lipids; D019270:Fructosamine; D014508:Urea; D003404:Creatinine