[Opioids evoke postural asymmetry in rats: the side of the flexed paw depends on the type of opioid agonist].
Opioid kappa-agonists bremazocine and dynorphin (1-13), sigma-agonist SKF 10.047 and delta-agonist D-Ala2, D-Leu5-enkephalin (DADL) induce postural asymmetry of rats hind limbs under subarachnoidal administration below the level of spinal cord section (T3-T4). The side of the flexed leg depends on the opioid agonist type: bremazocine and dynorphin (1-13) induce predominantly right flexion. SKF 10.047--the left flexion, but not in all doses, DADL--in small doses (1 and 100 pg per animal)--of the right one, in larger doses (up to 10 ng per animal)--of the left one. Saline and opiate mu-agonist morphine do not induce postural asymmetry. Opiate antagonist naloxone prevents asymmetry development when injected prior opioid agonists, and also decreases the number of asymmetries induced by these agonists. Naloxone alone does not influence the per cent of animals with pose asymmetry. The opioid receptors are involved in asymmetry development. The revealed ability of opioid kappa-, delta- and sigma-agonists may be based on lateralization of opioid receptors in the rat spinal cord.
Kobylianskiĭ
A G
AG
Bakalkin
G Ia
GIa
D000818:Animals; D003655:Decerebrate State / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000494:pharmacology*; D005528:Foot / Q000187:drug effects* / Q000502:physiology; D007839:Functional Laterality / Q000187:drug effects* / Q000502:physiology; D006614:Hindlimb; D009270:Naloxone / Q000494:pharmacology; D011187:Posture; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects
D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone
Opioidy vyzyvaiut asimmetriiu pozy u krys : storona fleksirovannoĭ lapy zavisit ot tipa opioidnogo agonista.