title: Immunization against the polyoma tumor-specific transplantation antigen (TSTA) with polyoma T-antigens.
abstract: The relationship between the polyoma virus tumor-specific transplantation antigen (TSTA) and 2 of the virus proteins coded from the early region of polyomavirus was investigated. Mice were immunized with small T antigen and a truncated mutant of middle T antigen, both purified from genetically engineered Escherichia coli. The 2 proteins induced protective immunity against polyomavirus-induced tumors, but not against non-polyoma tumors, indicating that one or more of the polyoma T antigens are directly involved in a TSTA function.
authors.affiliation: Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Ramqvist
authors.forename: D O
authors.initials: DO
authors.lastname: Pallas
authors.forename: J
authors.initials: J
authors.lastname: DeAnda
authors.forename: L
authors.initials: L
authors.lastname: Ahrlund-Richter
authors.forename: G
authors.initials: G
authors.lastname: Reinholdsson
authors.forename: T M
authors.initials: TM
authors.lastname: Roberts
authors.forename: B S
authors.initials: BS
authors.lastname: Schaffhausen
authors.forename: T
authors.initials: T
authors.lastname: Dalianis
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000951:Antigens, Neoplasm / Q000276:immunology*; D000952:Antigens, Polyomavirus Transforming / Q000008:administration & dosage* / Q000235:genetics; D006649:Histocompatibility Antigens / Q000276:immunology*; D007114:Immunization; D051379:Mice; D011120:Polyomavirus / Q000276:immunology*; D011994:Recombinant Proteins / Q000008:administration & dosage; D014412:Tumor Virus Infections / Q000473:pathology / Q000517:prevention & control*; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D000951:Antigens, Neoplasm; D000952:Antigens, Polyomavirus Transforming; D006649:Histocompatibility Antigens; D011994:Recombinant Proteins; D014765:Viral Vaccines; C029237:tumor-associated transplantation antigen