BN/GRP-like peptides and receptors in small cell lung cancer.
BN/GRP-like peptides are produced in high concentrations in SCLC cell lines and in low concentrations in beta-lymphoblastoid cell lines. The BN/GRP-like peptides are secreted from SCLC cell line NCI-H345 by stimuli which elevate the intracellular cAMP levels. These stimuli include theophylline, PHI, secretin and VIP. Also, elevated plasma levels of BN/GRP-like peptides are found in patients with extensive SCLC. In these patients the levels of BN/GRP-like peptides can be increased further approximately 5-fold after secretin infusion. Because SCLC cells make and secrete BN/GRP-like peptides, they may function as regulatory peptides in this disease.
Moody
T W
TW
Biochemistry Department, George Washington University School of Medicine and Health Sciences, Washington, D.C. 20037.
Lebovic
G S
GS
Carney
D N
DN
Korman
L Y
LY
D018288:Carcinoma, Small Cell / Q000032:analysis*; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism; D019886:Gastrin-Releasing Peptide; D006801:Humans; D008175:Lung Neoplasms / Q000032:analysis*; D010455:Peptides / Q000032:analysis*; D018004:Receptors, Bombesin; D017981:Receptors, Neurotransmitter / Q000032:analysis*; D012633:Secretin / Q000494:pharmacology
D010455:Peptides; D018004:Receptors, Bombesin; D017981:Receptors, Neurotransmitter; D012633:Secretin; D019886:Gastrin-Releasing Peptide; D000242:Cyclic AMP