[Malignant lymphoma in rabbits induced by the administration of herpes virus-containing material from brown macaques].
Oncogenicity for rabbits of lymphotropic herpesvirus of M. arctoides (HVMA) isolated by us earlier from lymphoid cells of lines MAL-1-3 has been shown in the course of studies. Inoculation of animals both with HVMA-containing cells and cell-free virus caused the development of generalized malignant lymphomas of prolymphocytic-lymphoblastic character leading the animals to death. The molecular hybridization method permitted revealing DNA sequences related to the DNAs of B-lymphotropic herpesviruses of primates in the cells of HVMA-containing cultures, primarily-induced tumours, and in a cell line established from rabbit tumour. This fact is indicative of etiological role of HVMA in the development of malignant lymphomas in rabbits. The question about the origin of the C type particles found in MAL-1-3 and OK-1 cells remains open.
Timanovskaia
V V
VV
Voevodin
A F
AF
Iakovleva
L A
LA
Markarian
D S
DS
Ivanov
M T
MT
D000818:Animals; D004279:DNA, Viral / Q000032:analysis; D017977:Deltaretrovirus / Q000032:analysis; D006564:Herpesviridae / Q000472:pathogenicity*; D006568:Herpesvirus 1, Cercopithecine / Q000032:analysis / Q000302:isolation & purification / Q000472:pathogenicity*; D007621:Karyotyping; D008223:Lymphoma / Q000209:etiology* / Q000382:microbiology / Q000648:ultrastructure; D008251:Macaca / Q000382:microbiology*; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D009693:Nucleic Acid Hybridization; D011817:Rabbits; D013997:Time Factors; D014407:Tumor Cells, Cultured
D004279:DNA, Viral
Zlokachestvennye limfomy u krolikov, vyzvannye vvedeniem materiala, soderzhashchego virus gerpesa burykh makakov.