Delayed hypersensitivity reactions to virus-augmented syngeneic and allogeneic tumor associated antigens.
Delayed hypersensitivity (DH) reactions to intact MSV-induced tumor cells or their crude membranes (CM) were studied across the H-2 histocompatibility barrier, using the radioisotopic footpad assay. Allogeneic as well as syngeneic tumor cells or their CM produced significant DH reactions in MSV-immune mice. CM from these cells after infection with influenza virus induced a stronger tumor-specific DH reaction in immune mice than did CM from uninfected cells. These results indicate that H-2 histocompatibility is not always required for induction of a cell-mediated immune response to tumor associated antigens and support the feasibility of a tumor specific skin test in humans using CM of autologous or allogeneic cultured human tumor cells.
Takeichi
N
N
Cell Biology Section, National Cancer Institute, Bethesda Maryland 20014.
Oikawa
T
T
Austin
F C
FC
Boone
C W
CW
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008722:Methods; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009053:Sarcoma Viruses, Murine / Q000276:immunology*
D000951:Antigens, Neoplasm