title: [Characteristics of purine nucleotide metabolism and GMP-reductase activity in chicken tissues].
abstract: The [3H]guanosine and [3H]guanine label is shown to be distributed unevenly in the purine components of chicken tissues. 60 min after isotope administration about 80% of radioactivity is localized in xanthine and uric acid in the liver and duodenum, that agrees with high activity of purine nucleoside phosphorylase (EC 2.4.2.1) and guanine deaminase (EC 3.5.4.3). At the same time over 50% of label is found in the spleen in adenine nucleotides of the pool, RNA as well as in hypoxanthine and only 20% in oxypurines. Such a distribution of the label is in direct correlation with the activity of GMP-reductase (EC 1.6.6.8) catalyzing the reduction deamination of GMP in IMP.
authors.forename: V A
authors.initials: VA
authors.lastname: Kokunin
authors.forename: A V
authors.initials: AV
authors.lastname: Kotsiuruba
authors.forename: S S
authors.initials: SS
authors.lastname: Tarakanov
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Kostychev
mesh_terms: D000818:Animals; D002384:Catalysis; D002645:Chickens; D050899:GMP Reductase; D006157:Guanosine Monophosphate / Q000378:metabolism; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism; D007291:Inosine Monophosphate / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D011685:Purine Nucleotides / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D007042:Hypoxanthines; D011685:Purine Nucleotides; D007291:Inosine Monophosphate; D019271:Hypoxanthine; D006157:Guanosine Monophosphate; D009247:NADH, NADPH Oxidoreductases; D050899:GMP Reductase
vernacular_title: Osobennosti obmena purinovykh nukleotidov i aktivnost' GMP-reduktazy v tkaniakh ptits.