title: Fibrostatins, new inhibitors of prolyl hydroxylase. I. Taxonomy, isolation and characterization.
abstract: Fibrostatins, potent inhibitors of prolyl hydroxylase, were isolated as orange crystals from the culture broth of strain No. 23924, which was identified as Streptomyces catenulae subsp. griseospora. In vitro inhibitory activity (ID50 value) of fibrostatins A, B, C, D, E and F against prolyl hydroxylase of chick embryos was 23, 39, 29, 180, 10 and 14 microM, respectively.
authors.affiliation: Applied Microbiology Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ishimaru
authors.forename: T
authors.initials: T
authors.lastname: Kanamaru
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: H
authors.initials: H
authors.lastname: Okazaki
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003545:Cysteine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D009285:Naphthoquinones / Q000302:isolation & purification* / Q000494:pharmacology; D011393:Procollagen-Proline Dioxygenase / Q000037:antagonists & inhibitors*; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000032:analysis
chemical_list: D009285:Naphthoquinones; C058033:fibrostatin C; D011393:Procollagen-Proline Dioxygenase; D003545:Cysteine