Detection of DNA transcripts of measles genes in multiple sclerosis brain tissue by transfection.
Transfection studies on DNA obtained from 16 multiple sclerosis (MS) and 13 non-MS brain tissues suggested that 3/16 (19%) MS and 3/13 (23%) non-MS samples contained contaminating measles virus double-stranded RNA, and that 6/16 (38%) MS and 0/13 non-MS samples contained DNA transcripts of measles genes. It is argued that the DNA transcripts most probably originated from dual retrovirus and measles infections in the subjects.
Greenham
L W
LW
Department of Microbiology, University of Bristol, U.K.
Hicks
D
D
Smith
S
S
D000328:Adult; D000368:Aged; D001923:Brain Chemistry; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008459:Measles virus / Q000235:genetics*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000382:microbiology*; D012192:Retroviridae Infections / Q000382:microbiology*; D014162:Transfection
D004279:DNA, Viral