Pathways of alpha 1-adrenergic action: comparison with V1-vasopressin and A1-angiotensin.
The relation between the induction of phosphatidylinositol labelling and ureagenesis by epinephrine (alpha 1-adrenergic action), vasopressin, and angiotensin II was studied in liver cells. It was observed that the alpha 1-adrenergic activation consistently induced a greater stimulation of ureagenesis than the vasopressor peptides. In contrast, vasopressin stimulated phosphatidylinositol labelling to a much greater extent than epinephrine or angiotension II. We suggest that in addition to phosphoinositide turnover, alpha 1-adrenergic action involves other factor(s) in its mechanism of signal transduction.
Garcia-Sáinz
J A
JA
Departamento de Bioenergética, Universidad Nacional Autónoma de México.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D014508:Urea / Q000096:biosynthesis; D014667:Vasopressins / Q000494:pharmacology*
D010716:Phosphatidylinositols; D011942:Receptors, Adrenergic, alpha; D014667:Vasopressins; D000804:Angiotensin II; D014508:Urea; D011433:Propranolol; D004837:Epinephrine