title: [Fatal pulmonary leukoagglutination after administration of fresh frozen plasma].
abstract: A case is reported of a 73 year old female patient who died during surgery for enlarged nephrectomy as a result of a massive non-cardiogenic pulmonary oedema. She had been given 2 red cell concentrates (450 g) and 3 fresh frozen plasma units (900 g). A postmortem examination did not reveal any pulmonary embolus, acute myocardial infarct, haemorrhage or cardiac tamponade. Further tests on the sera of the 5 plasma donors revealed a neutrophil-specific anti-NA2 antibody. Alveolar leukostasis was confirmed on the postmortem lung slices. This type of transfusion accident occurs for about 1 in 5,000 units transfused, fortunately not all as serious. This case confirms once more that fresh frozen plasma is not the ideal treatment for acute hypovolaemia, 4% human albumin being safer.
authors.affiliation: Service d'Anesthésie-Réanimation, Hôpital Necker-Enfants Malades, Paris.
authors.forename: B
authors.initials: B
authors.lastname: Cléro
authors.forename: J L
authors.initials: JL
authors.lastname: Celton
authors.forename: A
authors.initials: A
authors.lastname: Atinault
authors.forename: J B
authors.initials: JB
authors.lastname: Cazalaa
authors.forename: G
authors.initials: G
authors.lastname: Barrier
mesh_terms: D000368:Aged; D000371:Agglutination; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D007962:Leukocytes / Q000276:immunology / Q000473:pathology; D010949:Plasma; D011654:Pulmonary Edema / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D065227:Transfusion Reaction
chemical_list: D007518:Isoantibodies
vernacular_title: Leucoagglutination pulmonaire mortelle après administration de plasma frais congelé.