title: [Hepatocellular carcinoma and hyperestrogenia in a male].
abstract: The case of a 38 year-old man with hepatocellular carcinoma in a non-cirrhotic liver is reported. Hyperestrogenosis with gynecomastia, polycythemia and proteinuria were present. After complete removal of the tumor, estrogen levels, red blood-cell volume and urine analysis did not return to normal and these pathologic findings were probably not paraneoplastic syndromes. Outcome was good, the patient remaining completely well without evidence of recurrence during the ensuing 30 months. The likely explanation for the persistent hyperestrogenosis was an excessive conversion of sexual hormones. The authors suggest that this abnormal hyperestrogenic state could promote hepatic neoplasia as it has been established in animals.
authors.affiliation: Service de Médecine Interne, Centre Hospitalier Lyon Sud, Pierre-Bénite.
authors.forename: G
authors.initials: G
authors.lastname: Salles
authors.forename: D
authors.initials: D
authors.lastname: Vital Durand
authors.forename: R
authors.initials: R
authors.lastname: Mackiewicz
authors.forename: M
authors.initials: M
authors.lastname: Pugeat
authors.forename: R
authors.initials: R
authors.lastname: Levrat
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D004967:Estrogens / Q000097:blood*; D006177:Gynecomastia / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D008297:Male
chemical_list: D004967:Estrogens
vernacular_title: Carcinome hépatocellulaire et hyperoestrogénie chez un homme.