5'-Nucleotidase in skin fibroblasts from patients with Duchenne muscular dystrophy.
The 5'-nucleotidase of plasma membranes of cultured skin fibroblasts from patients with Duchenne muscular dystrophy had a reduced affinity for its substrate, 5'-AMP. The Arrhenius plot of the temperature dependence of this enzyme activity was normal. There was no difference between patients and controls in the specific 5'-nucleotidase activity in the whole cell homogenates.
Sinclair
C E
CE
Department of Neurochemistry, Newcastle General Hospital, Newcastle upon Tyne, England.
Ecob-Prince
M S
MS
Pennington
R J
RJ
D015720:5'-Nucleotidase; D000293:Adolescent; D002455:Cell Division; D002462:Cell Membrane / Q000201:enzymology; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D005347:Fibroblasts / Q000166:cytology / Q000201:enzymology; D006801:Humans; D007223:Infant; D008297:Male; D009136:Muscular Dystrophies / Q000201:enzymology*; D009708:Nucleotidases / Q000378:metabolism*; D012867:Skin / Q000166:cytology / Q000201:enzymology*; D013696:Temperature
D009708:Nucleotidases; D015720:5'-Nucleotidase