title: Effects of intraportal infusion of glucose and lysine on food intake in intact and hepatic-vagotomized chickens.
abstract: Cockerels of a laying strain were prepared at 16 weeks of age with catheters whose tip lay in the hepatic portal vein, to study the effect of 3-h infusions of nutrients into the liver on food intake. L-Lysine (300 mg) and D-glucose (1.26 mg) reduced food intake by up to 25 and 24% respectively when infused into the portal vein and gave an additive effect (-47%) when infused together. Bilateral abdominal vagotomy prevented the reduction in food intake caused by the infusions, although when no infusion was given intakes were lower than in intact birds and the birds ate significantly fewer meals which were of a greater size. These results suggest a role for the liver in the control of food intake of the domestic fowl, with the vagus nerves communicating between this organ and the central nervous system.
authors.affiliation: University of Leeds, Department of Animal Physiology and Nutrition, U.K.
authors.forename: A A
authors.initials: AA
authors.lastname: Rusby
authors.forename: M H
authors.initials: MH
authors.lastname: Anil
authors.forename: P
authors.initials: P
authors.lastname: Chatterjee
authors.forename: J M
authors.initials: JM
authors.lastname: Forbes
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001921:Brain / Q000502:physiology; D002645:Chickens; D004435:Eating / Q000187:drug effects*; D005947:Glucose / Q000008:administration & dosage*; D005950:Glucose Solution, Hypertonic / Q000008:administration & dosage*; D008099:Liver / Q000294:innervation*; D008239:Lysine / Q000008:administration & dosage*; D008297:Male; D011956:Receptors, Cell Surface / Q000502:physiology; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D005950:Glucose Solution, Hypertonic; D011956:Receptors, Cell Surface; C027786:glucose receptor; D005947:Glucose; D008239:Lysine