[Cyclic nucleotides in the dynamic development of shock caused by the murine toxin of Yersinia pestis].
The authors have studied the effect of Y. pestis "mouse" toxin (LD50), injected intravenously to rats, on cAMP and cGMP content in the tissues of different organs (the lungs, liver, heart, spleen, kidneys, small intestine) and in the blood in the course of the development of toxinfection shock. The effect of Y. pestis "mouse" toxin on cyclic nucleotide content in the organs of experimental animals is determined by the sum of oppositely directed effects produced by the thermostable and thermolabile fractions of the toxin. Its thermostable fraction, when introduced in the dose used in the experiments, did not kill the animals. The most pronounced changes in the cyclic nucleotide content have been detected in the lungs which appear to be the main target organ for Y. pestis "mouse" toxin.
Cherkasova
T D
TD
Vengrov
P R
PR
Melikhov
V I
VI
Avrorov
V P
VP
Iurkiv
V A
VA
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004355:Drug Stability; D007275:Injections, Intravenous; D051381:Rats; D012772:Shock, Septic / Q000139:chemically induced / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects; D014118:Toxins, Biological / Q000633:toxicity*; D015010:Yersinia pestis
D014118:Toxins, Biological; D000242:Cyclic AMP; D006152:Cyclic GMP
Tsiklicheskie nukleotidy v dinamike razvitiia shoka, vyzyvaemogo "myshinym" toksinom Yersinia pestis.