Changes in angiotensin converting enzyme in testes and epididymis of rat due to serotonin administration.
Effect of exogenous serotonin and blockade of its endogenous production on Angiotensin Converting Enzyme (ACE) in testes and epididymis was studied. Serotonin (30 mg/kg) and p-chlorophenylalanine (100 mg/kg) were injected for 4 and 3 days respectively. Serotonin reduced the weights of testes, seminal vesicle and ventral prostate whereas epididymal weight increased due to fluid accumulation. ACE was significantly reduced in tissue and fluid fractions of testes and epididymis of serotonin treated rats. pCPA had no effect on ACE levels. Serotonin seems to have direct effect on epididymis also.
Singh
U S
US
Division of Biochemistry and Food Science, IVRI, Izatnagar/India.
Kumar
M V
MV
Panda
J N
JN
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D004822:Epididymis / Q000187:drug effects* / Q000201:enzymology; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D011467:Prostate / Q000187:drug effects; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects* / Q000201:enzymology
D000806:Angiotensin-Converting Enzyme Inhibitors; D012701:Serotonin; D007703:Peptidyl-Dipeptidase A; D010134:Fenclonine