title: Modulation of renal noradrenaline release by prejunctional receptor systems in vitro.
abstract: 1. The amount of noradrenaline released per nerve impulse from renal sympathetic nerves can be modulated through specific prejunctional receptors. 2. Under in vitro conditions activation of alpha 1-, alpha 2-, prostaglandin, adenosine, dopamine and serotonin receptors inhibits noradrenaline release from the kidney. 3. Stimulation of prejunctional beta-adrenoceptors, probably of the beta 2-subtype, as well as stimulation of prejunctional angiotensin II receptors facilitates noradrenaline release. Moreover, neuronally released noradrenaline inhibits its own release through activation of both prejunctional alpha 1- and alpha 2-adrenoceptors. 4. Locally produced PGE2, which is formed and released via stimulation of postjunctional alpha 1-adrenoceptors, as well as adenosine, released from postjunctional sites by renal nerve stimulation (RNS), seems to inhibit noradrenaline release through their specific prejunctional receptor systems.
authors.affiliation: Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: L C
authors.initials: LC
authors.lastname: Rump
mesh_terms: D000241:Adenosine / Q000502:physiology; D000818:Animals; D066298:In Vitro Techniques; D007668:Kidney / Q000294:innervation*; D009638:Norepinephrine / Q000096:biosynthesis* / Q000502:physiology; D011817:Rabbits; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D011945:Receptors, Angiotensin / Q000502:physiology; D011982:Receptors, Prostaglandin / Q000502:physiology; D013564:Sympathetic Nervous System / Q000378:metabolism*
chemical_list: D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011945:Receptors, Angiotensin; D011982:Receptors, Prostaglandin; D000241:Adenosine; D009638:Norepinephrine