title: [N-phosphonate synthesis of oligodeoxyribonucleotides with the use of a p-nitrophenylethyl blocking group].
abstract: p-Nitrophenylethyl blocking group was used to protect the endocyclic imido groups of guanine and thymine nucleoside 3'-H-phosphonates employed in the H-phosphonate synthesis of a large number of oligodeoxyribonucleotides varying in length from 8 to 45 units. A combination of the fully protected monomers with a condensing agent, pivaloyl chloride or mesitylenesulphonyl-3-nitro-1,2,4-triazole, provides a rapid and effective synthesis of long oligonucleotides.
authors.forename: N V
authors.initials: NV
authors.lastname: Skaptsova
authors.forename: A N
authors.initials: AN
authors.lastname: Kurkin
authors.forename: A V
authors.initials: AV
authors.lastname: Azhaev
mesh_terms: D001483:Base Sequence; D002852:Chromatography, Ion Exchange; D004591:Electrophoresis, Polyacrylamide Gel; D007202:Indicators and Reagents; D008969:Molecular Sequence Data; D009574:Nitro Compounds; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D063065:Organophosphonates
chemical_list: D007202:Indicators and Reagents; D009574:Nitro Compounds; D009838:Oligodeoxyribonucleotides; D063065:Organophosphonates
vernacular_title: N-foxfonatnyĭ sintez oligodezoksiribonukleotidov s ispol'zovaniem p-nitrofenilétil'noĭ zashchitnoĭ gruppy.