Localization of radiolabeled monoclonal antibody S74 in human scirrhous type gastric cancer xenografts in nude mice.
A mouse monoclonal antibody (MoAb), S74 against a human scirrhous gastric carcinoma cell line was developed. The radioiodinated antibody bound preferentially in vivo to xenografted tumors rather than to normal tissue, whereas tumor uptake of normal mouse IgG did not occur. Thus this MoAb was able to selectively localize a human tumor in an animal model, and clinically it may enable immunotherapy against scirrhous carcinoma of the stomach.
Yokota
T
T
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Takahashi
T
T
Yamaguchi
T
T
Otsuji
E
E
Sawai
K
K
Kitai
S
S
Kitamura
K
K
Noguchi
A
A
Ahn
T
T
D002293:Adenocarcinoma, Scirrhous / Q000276:immunology*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis*; D001666:Binding Sites, Antibody; D002460:Cell Line; D004064:Digestive System / Q000276:immunology; D006801:Humans; D007457:Iodine Radioisotopes; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000276:immunology*
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes