title: Intraepithelial and invasive neoplasia of the vulva in association with human papillomavirus infection.
abstract: Colposcopic examination of 335 women with cytologically detected human papillomavirus (HPV) revealed involvement of the cervix in 316 patients (94%), vagina in 276 (82%) and vulva in 148 (44%). A symptom complex of pruritus and superficial dyspareunia was found in 98 of the 148 patients with vulvar infection (66%). Histologic examination revealed HPV-associated vulvar intraepithelial neoplasia (VIN) in 11 of 148 biopsies (7.4%). Follow-up of the patients with HPV infection with or without VIN showed a spontaneous regression rate of 56% but also demonstrated progression to VIN 3 in two patients and to invasive carcinoma of the vulva in one.
authors.affiliation: Department of Gynaecologic Oncology, Mercy Maternity Hospital, East Melbourne, Victoria, Australia.
authors.forename: R S
authors.initials: RS
authors.lastname: Planner
authors.forename: J B
authors.initials: JB
authors.lastname: Hobbs
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D002278:Carcinoma in Situ / Q000473:pathology*; D003127:Colposcopy; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae; D014412:Tumor Virus Infections / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000473:pathology*