Topical antibiotics in chronic sickle cell leg ulcers.
A randomized, controlled, trial of a topical antibiotic preparation (neomycin, bacitracin, and polymyxin B) was performed in 30 patients with homozygous sickle cell (SS) disease and chronic leg ulceration. Over a period of 8 weeks, the reduction in ulcer size was significantly (P less than 0.05) greater in the treatment group than in the control group. The results suggest that these topical antibiotics may contribute to the therapy of chronic leg ulceration associated with sickle cell disease.
Baum
K F
KF
Medical Research Council Laboratories, University of the West Indies, Kingston, Jamaica.
MacFarlane
D E
DE
Maude
G H
GH
Serjeant
G R
GR
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D001414:Bacitracin / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009355:Neomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D011112:Polymyxin B / Q000008:administration & dosage / Q000627:therapeutic use*; D011113:Polymyxins / Q000627:therapeutic use*; D011897:Random Allocation
D004338:Drug Combinations; D011113:Polymyxins; D001414:Bacitracin; D009355:Neomycin; D011112:Polymyxin B