title: Midazolam-thiopental anesthetic interaction in patients.
abstract: The effect of thiopental on the induction dose-response curve for midazolam was studied in nonpremedicated ASA physical status I and II patients. As an endpoint of anesthesia, ability to open eyes on command was used. Dose-response curves for thiopental, midazolam, and their combination were determined with a probit procedure and compared with an isobolographic analysis. Interaction between midazolam and thiopental was found to be synergistic (supraadditive). The degree of midazolam-thiopental anesthetic synergism in surgical patients was close to that reported previously in rats with loss of the righting reflex as an index of anesthesia.
authors.affiliation: Department of Anesthesiology, Rebecca Sieff Government Hospital, Safed, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Tverskoy
authors.forename: G
authors.initials: G
authors.lastname: Fleyshman
authors.forename: E L
authors.initials: EL
authors.lastname: Bradley
authors.forename: I
authors.initials: I
authors.lastname: Kissin
mesh_terms: D000328:Adult; D000758:Anesthesia; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008874:Midazolam / Q000494:pharmacology*; D008875:Middle Aged; D011963:Receptors, GABA-A / Q000187:drug effects; D013874:Thiopental / Q000494:pharmacology*
chemical_list: D011963:Receptors, GABA-A; D013874:Thiopental; D008874:Midazolam