Antimicrobial activity of N,N'-dialkylpolymethylenediamines against some dental plaque bacteria.
Twenty N,N'-dialkylpolymethylendiamine derivatives were synthesized, and a study was made of their antimicrobial activities in vitro against four oral microorganisms which are related to dental caries. The maximum activity was shown by N,N'-dinonyl or N,N'-didecyl derivatives among the complete homologous series of compounds studied.
Murata
Y
Y
School of Pharmacy, Hokuriku University, Kanazawa, Japan.
Mita
K
K
Miyamoto
E
E
Ueda
M
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003773:Dental Plaque / Q000382:microbiology*; D003959:Diamines / Q000494:pharmacology*; D005029:Ethylenediamines / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D003959:Diamines; D005029:Ethylenediamines