Stimulation of cellular DNA synthesis by wild type and mutant bovine papillomavirus DNA.
Microinjection of recombinant plasmids containing bovine papillomavirus type 1 DNA into the nuclei of mouse C127 cells results in the stimulation of cellular DNA synthesis. Mutations in the viral E2 gene have no apparent effect on this activity even though the same mutations prevent efficient C127 cell focus formation and inhibit transactivation by this gene.
Jaskulski
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D
Department of Pathology, Temple Medical School, Philadelphia, Pennsylvania.
Kaczmarek
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DiMaio
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D
D000818:Animals; D052688:Bovine papillomavirus 1 / Q000235:genetics*; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism; D002472:Cell Transformation, Viral; D004261:DNA Replication; D004274:DNA, Recombinant / Q000008:administration & dosage / Q000378:metabolism*; D004279:DNA, Viral / Q000235:genetics*; D051379:Mice; D008845:Microinjections; D009154:Mutation; D027383:Papillomaviridae / Q000235:genetics*; D010957:Plasmids; D013045:Species Specificity
D004274:DNA, Recombinant; D004279:DNA, Viral