The effects of intracerebroventricular infusion of atrial natriuretic factor in conscious sheep.
The effects of 24-hour intracerebroventricular infusion of human atrial natriuretic factor (ANF) and two related fragments were studied in conscious sheep. ANF (1-28) had no effect on either mean arterial pressure (MAP) or heart rate (HR) when infused at 3 or 10 micrograms/hr, however a small diuresis and an increase in urinary sodium (Na) excretion was observed. The smaller fragment, ANF (5-27) infused at 10 micrograms/hr, increased MAP, HR and body temperature, although the same rate of infusion of ANF (5-28) was without effect. All peptides increased plasma sodium concentration and plasma osmolality. None of the peptides affected plasma ACTH, glucose or renin concentration. ANF (1-28) had no effect on either Na intake or water intake in Na-depleted sheep. These studies suggest that members of the ANF family can influence a number of physiological functions following central administration.
Parkes
D G
DG
Howard Florey Institute of Experimental Physiology and Medicine, Parkville, Australia.
Coghlan
J P
JP
Weisinger
R S
RS
Scoggins
B A
BA
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004326:Drinking / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007276:Injections, Intraventricular; D011188:Potassium / Q000378:metabolism; D012016:Reference Values; D012083:Renin / Q000097:blood; D012756:Sheep; D012890:Sleep / Q000187:drug effects*; D012964:Sodium / Q000378:metabolism
D001786:Blood Glucose; D009320:Atrial Natriuretic Factor; D000324:Adrenocorticotropic Hormone; D012964:Sodium; D012083:Renin; D011188:Potassium