title: The genome of budgerigar fledgling disease virus, an avian polyomavirus.
abstract: Budgerigar fledgling disease virus (BFDV) represents the first avian member of the Polyomavirus family. In contrast to mammalian polyomaviruses BFDV exhibits unique biological properties, in particular it is able to cause an acute disease with distinct organ manifestations in affected birds. Here we present the complete nucleotide sequence of the BFDV genome, consisting of 4980 bp. When compared to published nucleotide sequences of other polyomaviruses, the BFDV genome exposes a number of very similar structural features, and undoubtedly qualifies as a member of that family of viruses. The most important differences include a large T antigen remarkably reduced in size, and an origin of replication region with fundamental deviations from the origin structure of all other polyomaviruses. The specific characteristics of the BFDV genome may be used to place this virus into a distinct subgroup within the Polyomavirus family and may give a clue to the elucidation of its extraordinary biological properties.
authors.affiliation: Institut für Mikrobiologie und Molekularbiologie, Justus-Liebig-Uniersität Giessen, Federal Republic of Germany.
authors.forename: O
authors.initials: O
authors.lastname: Rott
authors.forename: M
authors.initials: M
authors.lastname: Kröger
authors.forename: H
authors.initials: H
authors.lastname: Müller
authors.forename: G
authors.initials: G
authors.lastname: Hobom
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics; D001483:Base Sequence; D001715:Bird Diseases / Q000382:microbiology; D005814:Genes, Viral; D008969:Molecular Sequence Data; D010240:Parakeets; D011120:Polyomavirus / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012045:Regulatory Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid; D014412:Tumor Virus Infections / Q000382:microbiology / Q000662:veterinary; D014764:Viral Proteins / Q000235:genetics
chemical_list: D000952:Antigens, Polyomavirus Transforming; D014764:Viral Proteins