[Transcatheter arterial chemoembolization in liver metastases of colorectal cancer (lipiodol cisplatin sandwich therapy].
The transcatheter arterial chemoembolization (LPD-CDDP Sandwich Therapy) developed by us was applied to 15 patients with unresectable liver metastases (H2-H3) of colorectal cancer. Computed tomography or ultra-sonography revealed an overall response rate of 27%. Serum CEA values decreased to lower than the pre-TACE value in 11 (78%) of 14 patients excluding one showing the normal range before TACE. The post-TACE CEA values were completely normalized in 2 of the 11 patients. One-year cumulative survival rate was 72% and median survival was 18 months, showing a prolongation compared with intraarterial or systemic chemo-immunotherapy. The histological antitumor effect of LPD-CDDP Sandwich Therapy was examined in the hepatic specimens from 6 patients who underwent hepatectomy after this therapy for liver metastases (H1-H2) of colo-rectal cancer. The necrotic area in the main tumor was 95-100% in 3 patients, 75-94% in 2 patients and 50-74% in one patient. LPD-CDDP sandwich therapy was considered an effective treatment without any serious side effects for liver metastases of colo-rectal cancer.
Kameyama
M
M
Dept. of Surgery, Center for Adult Diseases, Osaka.
Fukuda
I
I
Imaoka
S
S
Sasaki
Y
Y
Shibata
T
T
Furukawa
H
H
Koyama
H
H
Iwanaga
T
T
Ishiguro
S
S
D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use; D003110:Colonic Neoplasms; D004621:Embolization, Therapeutic / Q000379:methods; D005069:Evaluation Studies as Topic; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage* / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D012004:Rectal Neoplasms; D012074:Remission Induction
D007459:Iodized Oil; D002945:Cisplatin