[Promoting effect of the Chinese medicinal herb, wikstroemia chamaedaphne and tung oil extracts on carcinoma of the uterine cervix induced by HSV-2 or methylcholanthrene (MCA) in mice].
The promoting effect of the Chinese medicinal herb, Wikstroemia chamaedaphne and Tung oil extracts (WC and HHPA) on carcinoma of uterine cervix induced by HSV-2 or MCA in mice was studied. The results showed that WC and HHPA extracts were not carcinogenic themselves. After carcinogen HSV-2 and MCA treatment, WC and HHPA were added separately. The inducing rates by HSV-2 increased from 7.4% to 21.1% and 26.3%, those by MCA increased from 56.5% to 82.8% and 84.4%. There was a significant difference between the combined groups and groups with HSV-2 or MCA only. The experimental results suggest that these two kinds of extracts play a promoting effect on carcinogenesis. The relation between the carcinogenesis of uterine cervix or nasopharynx and WC or HHPA extracts is discussed.
Sun
Y
Y
Institute of Virology, Hubei Medical College, Wuhan.
Chen
M H
MH
Zhang
Y X
YX
Xiao
H
H
Liu
H Y
HY
Chen
X
X
Zeng
Y
Y
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced*; D003043:Cocarcinogenesis; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005260:Female; D008748:Methylcholanthrene; D051379:Mice; D010703:Phorbol Esters / Q000009:adverse effects*; D018139:Simplexvirus; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced*
D004365:Drugs, Chinese Herbal; D010703:Phorbol Esters; C028113:croton factor F1; D008748:Methylcholanthrene