title: Cyclic nucleotides and the activity of glia maturation factor in the hypoplastic cerebellum of developing jaundiced Gunn rats.
abstract: Developmental changes of cyclic nucleotides were studied in the hypoplastic cerebellum of jaundiced Gunn rats over the period of postnatal days 8 to 30. The mitogenic activity of glia maturation factor was also measured at day 15. In jaundiced homozygotes (jj), the amount of cyclic GMP on a protein basis was not significantly different from that in control heterozygotes (j+) at either day 8 or 15, but at day 30 it was reduced to about 19% of the control. On the other hand, a lowered nucleotide level on a wet weight basis in jj rats was already statistically significant at day 15. In contrast to cyclic GMP, the rates of increase of cyclic AMP on a wet weight basis were almost the same in the two groups of rats, but the nucleotide levels on a protein basis at days 15 and 30 were a little, but significantly, higher in jj rats than in j+ rats. The activity of glia maturation factor in jj rats was found to be 1.5-3 times as high as that in j+ rats. Possible implications of the present results are discussed.
authors.affiliation: Department of Perinatology, Aichi Prefecture Colony, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Aono
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: R
authors.initials: R
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: R
authors.initials: R
authors.lastname: Semba
authors.forename: S
authors.initials: S
authors.lastname: Kashiwamata
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development* / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism* / Q000473:pathology; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D020904:Glia Maturation Factor; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D051381:Rats; D011911:Rats, Gunn
chemical_list: D020904:Glia Maturation Factor; D009419:Nerve Tissue Proteins; D009712:Nucleotides, Cyclic; D000242:Cyclic AMP; D006152:Cyclic GMP