Effect of gold thiomalate on cell proliferation and collagen synthesis of synovial cells in culture.
Human synovial cells from cases of rheumatoid and osteoarthritis were cultured and at their 3-5 passages, were treated with gold thiomalate. At early-log phase gold thiomalate arrested the proliferation of cells. However, at confluent state shere was a slight proliferation of synovial cells. This was followed by an increase in prolyl hydroxylase, collagen and protein synthesis, indicating that gold salts directly stimulate the synovial cells.
Kuttan
R
R
Amala Cancer Research Centre, Amala Nagar, Trichur.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D006052:Gold Sodium Thiomalate / Q000494:pharmacology*; D006801:Humans; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism; D013583:Synovial Membrane / Q000166:cytology / Q000187:drug effects*
D006052:Gold Sodium Thiomalate; D003094:Collagen; D011393:Procollagen-Proline Dioxygenase