Evidence that prolonged alpha-MSH infusion enhances the steroidogenic capacity of rat adrenal zona glomerulosa in vivo.
Prolonged infusion with 120 micrograms/kg/day alpha-MSH significantly increased basal plasma level of aldosterone in the rat, as well as raised the acute aldosterone response to a bolus administration of a high dose of ACTH or angiotensin II. These findings suggest that chronic alpha-MSH treatment stimulates the steroidogenic capacity of rat zona glomerulosa.
Mazzocchi
G
G
Department of Anatomy, University of Padua, Italy.
Malendowicz
L K
LK
Gottardo
G
G
Nussdorfer
G G
GG
D000311:Adrenal Glands / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000378:metabolism*; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D003345:Corticosterone / Q000378:metabolism*; D008297:Male; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D000521:alpha-MSH / Q000494:pharmacology*
D000804:Angiotensin II; D000450:Aldosterone; D000521:alpha-MSH; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone