title: Suloctidil-induced hepatotoxicity.
abstract: Suloctidil is a new drug that is currently being evaluated in many clinical trials for use in dementia and thrombotic disorders. Hepatotoxicity has to date been reported exclusively in the European literature, and the few available histologic descriptions have been reported in the French language. We report a case of suloctidil-induced hepatotoxicity documented by serum liver biochemical tests and liver biopsy. Histologic features included focal necrosis of hepatocytes, mild hyperplasia of Kupffer cells, and other features suggestive of mild acute hepatitis.
authors.affiliation: Department of Medicine, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee.
authors.forename: M W
authors.initials: MW
authors.lastname: Chung
authors.forename: R A
authors.initials: RA
authors.lastname: Komorowski
authors.forename: R R
authors.initials: RR
authors.lastname: Varma
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D011412:Propanolamines / Q000009:adverse effects*; D013468:Suloctidil / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D011412:Propanolamines; D013468:Suloctidil