[Immunomodulating effect of substances activating and blocking the GABA receptor-ionophore complex].
A direct agonist of GABAA-receptor muscimol was shown to stimulate the immune response in CBA mice, whereas a competitive inhibitor of GABA-receptor bicuculline and a blocker of Cl-ionophores picrotoxin were found to inhibit the immune response. The immunomodulating effect of the GABAergic system was suggested.
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D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007114:Immunization; D007476:Ionophores / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D009118:Muscimol / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000276:immunology; D012397:Rosette Formation; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D001640:Bicuculline; D007476:Ionophores; D009118:Muscimol; D010852:Picrotoxin; D011963:Receptors, GABA-A
Immunomoduliruiushchee vliianie veshchestv, aktiviruiushchikh i blokiruiushchikh kompleks GAMK-retseptor--ionofor.