Prophylactic efficacy of buparvaquone in experimentally induced Theileria annulata infection in calves.
The antitheilerial activity of buparvaquone (BW 720C) was evaluated in experimentally induced Theileria annulata infections in cross-bred male calves. T. annulata infections were induced by injecting a suspension of infected ground tick tissue suspension (GUTTS) equivalent to two ticks subcutaneously into each calf. Buparvaquone at a dose of 2.5 mg kg-1 body weight was given as a single injection (intramuscularly) on Day 0 (Group 1), Day 8 (Group 2) and Day 12 (Group 3) post-infection. The animals in Groups 4 and 5 were untreated and challenged controls, respectively. All of the recovered animals from Groups 1-4 were challenged with a lethal dose of T. annulata at 6 weeks post-infection. The immunized animals were resistant to the homologous challenge, which killed three of four control animals (Group 5); the controls showed typical antemortem and post-mortem lesions of theileriosis.
Bansal
G C
GC
Division of Parasitology, Indian Veterinary Research Institute, Izatnagar, India.
Sharma
N N
NN
D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D002417:Cattle; D008297:Male; D009285:Naphthoquinones / Q000627:therapeutic use*; D011897:Random Allocation; D013801:Theileriasis / Q000188:drug therapy / Q000517:prevention & control*
D000981:Antiprotozoal Agents; D009285:Naphthoquinones; C046326:buparvaquone