title: Cytomegalovirus infection after autologous bone marrow transplantation with comparison to infection after allogeneic bone marrow transplantation.
abstract: Cytomegalovirus (CMV) infection was detected in 65 of 143 (45%) autologous bone marrow transplant (BMT) patients. CMV pneumonitis occurred in only 2% of the patients and CMV retinitis occurred in none. Infection occurred in half of the 40 initially seronegative patients and 47% of the 94 initially seropositive patients. Among initially seropositive patients, platelet recovery was slower in infected patients than in those not infected (97 v 35 days median, P = .003), and neutrophil recovery was slightly delayed in infected patients (31 days v 24 days, P = .02). Although the incidence of CMV infection was comparable in autologous and allogeneic BMT patients, CMV pneumonitis was less frequent in autologous BMT patients (2% v 12%, P less than .001). The risk for CMV pneumonitis in autologous BMT patients was comparable with that in allogeneic BMT patients without graft-v-host disease (GVHD) (2% v 6%), but significantly lower than the risk in allogeneic BMT patients with GVHD (2% v 23%, P less than .001).
authors.affiliation: Oncology Center, Johns Hopkins Medical Institutions, Baltimore, MD.
authors.forename: J R
authors.initials: JR
authors.lastname: Wingard
authors.forename: D Y
authors.initials: DY
authors.lastname: Chen
authors.forename: W H
authors.initials: WH
authors.lastname: Burns
authors.forename: D J
authors.initials: DJ
authors.lastname: Fuller
authors.forename: H G
authors.initials: HG
authors.lastname: Braine
authors.forename: A M
authors.initials: AM
authors.lastname: Yeager
authors.forename: H
authors.initials: H
authors.lastname: Kaiser
authors.forename: P J
authors.initials: PJ
authors.lastname: Burke
authors.forename: M L
authors.initials: ML
authors.lastname: Graham
authors.forename: G W
authors.initials: GW
authors.lastname: Santos
mesh_terms: D016026:Bone Marrow Transplantation; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000209:etiology*; D006086:Graft vs Host Disease; D006801:Humans; D007958:Leukocyte Count; D008396:Maryland; D010976:Platelet Count; D011024:Pneumonia, Viral / Q000453:epidemiology / Q000209:etiology; D011183:Postoperative Complications / Q000453:epidemiology*; D012173:Retinitis / Q000453:epidemiology / Q000209:etiology; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014775:Virus Activation