Uric acid nephrolithiasis and acute renal failure secondary to streptozotocin nephrotoxicity.
Uric acid nephrolithiasis developed in a 75-year-old man who had received a large cumulative dose of streptozotocin for treatment of metastatic islet cell carcinoma of the pancreas. Oligoanuric renal failure mediated by massive intraureteral uric acid deposits occurred despite normal serum concentrations of uric acid. This case implicates the uricosuric effects of streptozotocin in the pathogenesis of uric acid nephropathy and suggests that renal uric acid excretion should be monitored routinely in patients receiving large cumulative doses of this drug.
Hricik
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DE
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Goldsmith
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GH
D058186:Acute Kidney Injury / Q000139:chemically induced*; D007516:Adenoma, Islet Cell / Q000188:drug therapy; D000368:Aged; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007669:Kidney Calculi / Q000032:analysis / Q000139:chemically induced*; D008297:Male; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D013311:Streptozocin / Q000009:adverse effects* / Q000627:therapeutic use; D014527:Uric Acid / Q000378:metabolism*
D014527:Uric Acid; D013311:Streptozocin; D005472:Fluorouracil