[Characteristics of the development of humoral immunity to hepatitis A in children's day care centers].
Solid-phase enzyme immunoassay was used to study changes in the frequency and levels of antibody to hepatitis A virus (anti-HAV) in 567 children in 20 isolated groups of 5 day-care centers of the town of Kemerovo. The observation period included the seasonal rise in hepatitis A incidence. An increase in the portion of seropositive children occurred in the groups where manifest or asymptomatic infection with hepatitis A existed. The number of seropositive subjects in the groups where the children were given immunoglobulin by epidemiological indications increased by 0-8%, and in those without immunoglobulin by 11-37.5%. The passive antibody received with immunoglobulin were detected in the originally seronegative children and declined to undetectable levels within 2 months. Subsequently, no clinical cases of hepatitis A or asymptomatic seroconversions were observed in these children. Some cases of reinfection showing an increase in anti-HAV levels but without clinical manifestations of hepatitis A were detected.
Prikazchikov
S A
SA
Karetnyĭ
Iu V
IuV
Vakar
E I
EI
Balaian
M S
MS
Zenkov
V A
VA
D000917:Antibody Formation; D000956:Antigens, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D006506:Hepatitis A / Q000453:epidemiology / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000032:analysis; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M / Q000032:analysis; D012008:Recurrence; D012621:Seasons; D012800:Siberia; D014505:Urban Population
D000956:Antigens, Viral; D006508:Hepatitis Antibodies; D007075:Immunoglobulin M
Osobennosti formirovaniia gumoral'nogo immuniteta k gepatitu A v kollektivakh detskikh doshkol'nykh uchrezhdeniĭ.