title: Peripheral nerve repair using muscle autografts. Recovery of transmission in primates.
abstract: Skeletal muscle grafts, when thawed after freezing, can be used to repair peripheral nerves. This method was used after transection of the median nerve in the upper arm in marmosets. Examination at 28 days showed total denervation of flexor carpi radialis; at 150 days electrophysiological evidence of recovery of nerve conduction across the graft and of muscle activation was seen. Sections at this time showed nerve fibres and new functional neuromuscular junctions in the muscle. It is concluded that effective reinnervation of target muscles is possible after peripheral nerve repair using skeletal muscle autografts.
authors.affiliation: Department of Anatomy, Royal College of Surgeons of England, London.
authors.forename: J M
authors.initials: JM
authors.lastname: Gattuso
authors.forename: A H
authors.initials: AH
authors.lastname: Davies
authors.forename: M A
authors.initials: MA
authors.lastname: Glasby
authors.forename: S E
authors.initials: SE
authors.lastname: Gschmeissner
authors.forename: C L
authors.initials: CL
authors.lastname: Huang
mesh_terms: D000200:Action Potentials; D000818:Animals; D002143:Callitrichinae; D002350:Carpus, Animal; D004576:Electromyography; D005552:Forelimb / Q000294:innervation; D005615:Freezing; D008475:Median Nerve / Q000293:injuries; D009132:Muscles / Q000473:pathology / Q000503:physiopathology / Q000637:transplantation*; D009416:Nerve Regeneration; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000503:physiopathology / Q000601:surgery; D009435:Synaptic Transmission; D014182:Transplantation, Autologous / Q000379:methods