A human inhibitor of tumor necrosis factor alpha.
Urine of some febrile patients exhibits a TNF-alpha inhibitory activity (TNF-alpha INH), sensitive to heat and trypsin, with an apparent mol wt of 40-60 X 10(3) and a pI range of 5.5-6.1. As for the Il-1 INH, the TNF INH activity involves a competitive mechanism of action suggesting the existence of a family of negative feedback-regulating molecules interfering with cytokines actions.
Seckinger
P
P
Department of Medicine, University Hospital, Geneva, Switzerland.
Isaaz
S
S
Dayer
J M
JM
D018288:Carcinoma, Small Cell / Q000652:urine; D002850:Chromatography, Gel; D005334:Fever / Q000209:etiology / Q000652:urine*; D054747:Histiocytic Sarcoma / Q000652:urine; D006801:Humans; D007739:L Cells / Q000187:drug effects; D008970:Molecular Weight; D009220:Myositis / Q000652:urine; D018805:Sepsis / Q000652:urine; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D014556:Urine / Q000032:analysis
D014409:Tumor Necrosis Factor-alpha