title: Abnormal scintigraphic evolution in AA hepatic amyloidosis.
abstract: A patient with AA amyloidosis secondary to ankylosing spondylitis showed intense liver uptake of Tc-99m MDP on bone imaging. The biopsy showed hepatic amyloid deposition. A repeat bone scan with Tc-99m MDP 1 year later was negative, although the clinical signs and liver function tests of the patient had not changed. A mechanism might exist, other than the affinity of amyloid to calcium, which would explain the extraosseous uptake of pyrophosphates and diphosphonates in organs and soft tissues affected by systemic amyloidosis.
authors.affiliation: Nuclear Medicine Service, Hospital Clinic, Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Lomeña
authors.forename: R
authors.initials: R
authors.lastname: Roselló
authors.forename: F
authors.initials: F
authors.lastname: Pons
authors.forename: M
authors.initials: M
authors.lastname: Grau
authors.forename: A
authors.initials: A
authors.lastname: García
authors.forename: A
authors.initials: A
authors.lastname: Catafau
authors.forename: J
authors.initials: J
authors.lastname: Setoain
mesh_terms: D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism; D011756:Diphosphates; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism; D008107:Liver Diseases / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011859:Radiography; D011877:Radionuclide Imaging; D013167:Spondylitis, Ankylosing / Q000150:complications; D013667:Technetium; D013669:Technetium Tc 99m Medronate / Q000378:metabolism; D016698:Technetium Tc 99m Pyrophosphate
chemical_list: D011756:Diphosphates; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium; D013669:Technetium Tc 99m Medronate