Correlation of ovarian follicle size and the urinary excretion of oestrone glucuronide, luteinizing hormone and pregnanediol glucuronide in spontaneous cycles.
Ovarian follicular development was investigated in 17 apparently normal women in whom ovulation was dated using real-time ultrasonography. Ultrasonic determination of follicular growth was performed on a daily basis with a real-time sector scanner, and correlated with daily concentrations of oestrone-3-glucuronide (E1-3-G), luteinizing hormone (LH) and the ratio of E1-3-G to pregnanediol-3 alpha-glucuronide (Pd-3 alpha-G) in early morning urine. The main results from ultrasonography showed that all patients except one developed follicles greater than 1.8 cm, with a mean growth rate of 0.18 cm/day. There was a statistically significant correlation between the mean follicular diameter and the mean concentrations of urinary E1-3-G (r = 0.95, P less than 0.001) and ratio of E1-3-G to Pd-3 alpha-G (r = 0.97, P less than 0.001) during the 8 days prior to ovulation.
Adekunle
A O
AO
Department of Obstetrics and Gynaecology, University College Hospital, Ibadan, Nigeria.
Collins
W P
WP
Whitehead
M I
MI
D000328:Adult; D004970:Estrone / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000652:urine*; D008597:Menstrual Cycle; D006080:Ovarian Follicle / Q000033:anatomy & histology* / Q000502:physiology; D010060:Ovulation; D011276:Pregnanediol / Q000031:analogs & derivatives* / Q000652:urine; D014463:Ultrasonography
C022270:pregnanediol-3 alpha-glucuronide; C015856:estrone-3-glucuronide; D004970:Estrone; D007986:Luteinizing Hormone; D011276:Pregnanediol