title: [Effect of neutral muscle proteases on parameters of the contraction of isolated myocardial strips from albino rats during overload and during the period of readaptation].
abstract: The treatment of an isolated myocardial strip with Ca2+-activated neutral muscle proteases reduced the contraction amplitude and the relaxation rate of the myocardium by 21.0 +/- 1.7% and 25.0 +/- 1.6%, respectively, and the tension development rate--by 13.0 +/- 1.0%. In the animals exposed to +5 Gz (for 25 min daily during 15 days) the inhibitory effect of neutral proteases on the contractile function of an isolated myocardial strip increased from 23.0 +/- 1.7% to 34.0 +/- 4.3%. The initial sensitivity of the contraction apparatus to proteases did not return to the baseline after 30 days of readaptation.
authors.forename: S B
authors.initials: SB
authors.lastname: Barinian
authors.forename: S S
authors.initials: SS
authors.lastname: Oganesian
authors.forename: M A
authors.initials: MA
authors.lastname: Eloian
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002154:Calpain / Q000494:pharmacology*; D003470:Culture Media; D066298:In Vitro Techniques; D008297:Male; D009132:Muscles / Q000201:enzymology*; D009200:Myocardial Contraction; D051381:Rats; D011919:Rats, Inbred Strains; D012399:Rotation; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D003470:Culture Media; D002154:Calpain
vernacular_title: Deĭstvie neitral'nykh myshechnykh proteaz na parametry sokrashcheniia izolirovannoĭ poloski miokarda belykh krys pri peregruzkei v period readaptatsii.