title: Renal function studies during intravenous acyclovir treatment of immune suppressed patients including renal transplantation.
abstract: We assessed the effect of acyclovir therapy on renal function during a course of therapy for herpesvirus disease. Renal function was assessed by measuring the clearances of inulin, albumin, and beta 2-microglobulin at the beginning and end of acyclovir therapy. Thirty-two patients had valid paired inulin clearances and 21 had valid paired albumin and beta 2-microglobulin clearances. No significant mean decrement of renal function was observed; however, 2 patients had a reversible renal dysfunction associated with acyclovir therapy which disappeared soon after discontinuation of the drug and was unassociated with a prior or recurrent renal dysfunction in short-term follow-up.
authors.affiliation: University of Texas Health Science Center, Houston.
authors.forename: K
authors.initials: K
authors.lastname: Kumor
authors.forename: R
authors.initials: R
authors.lastname: Conklin
authors.forename: J
authors.initials: J
authors.lastname: Woo
authors.forename: L
authors.initials: L
authors.lastname: Katz
authors.forename: C
authors.initials: C
authors.lastname: Strocchia
mesh_terms: D000212:Acyclovir / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D000419:Albuminuria / Q000139:chemically induced; D002648:Child; D003404:Creatinine / Q000097:blood; D005260:Female; D006566:Herpesviridae Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007262:Infusions, Intravenous; D007444:Inulin; D007674:Kidney Diseases / Q000139:chemically induced*; D016030:Kidney Transplantation; D008297:Male; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D001613:beta 2-Microglobulin; D007444:Inulin; D003404:Creatinine; D000212:Acyclovir