[Nephroblastoma with symptomatic neuronal differentiation].
We report the anatomoclinical analysis of a child with a renal tumor: the preoperative diagnosis was neuroblastoma, because of elevated dopamine urinary excretion and positive MIBG scintigraphy. The histopathological and immunohistochemical analysis revealed a prominent neural differentiation in a multicystic nephroblastoma. This observation recalls the Masson's proposed neuroectodermal histogenesis of Wilms tumor; however the currently accepted metanephrogenic blastematous origin is not reconsidered. This is the first case of nephroblastoma with a neural differentiation detectable otherwise from by pathological analysis.
Saint-André
J P
JP
Laboratoire d'Anatomie Pathologique, CHU, Angers.
Chapeau
M C
MC
Pein
F
F
D002454:Cell Differentiation; D002675:Child, Preschool; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D009396:Wilms Tumor / Q000473:pathology*
Néphroblastome avec différentiation neuronale symptomatique.