Presence of different types of procollagen messenger RNAs in human hepatoma cell lines.
Human hepatoma cell lines were shown for the first time to contain various types of procollagen mRNAs. The amounts and types of procollagen mRNAs differed depending on the cell lines. Pro alpha 1 (III) and pro alpha 1 (IV) collagen mRNAs were present in PLC/PRF/5, a hepatocellular carcinoma cell line, whereas pro alpha 1 (I), pro alpha 2 (I), pro alpha 1 (IV) and pro alpha 2 (V) collagen genes contrast, HepG2 cells derived from hepatoblastoma contained little, if any, mRNAs for these types of procollagens we had examined.
Inagaki
Y
Y
Genetics Division, National Cancer Center Research Institute, Tokyo, Japan.
Tsunokawa
Y
Y
Sakamoto
H
H
Hirohashi
S
S
Kobayashi
K
K
Hattori
N
N
Ramirez
F
F
Terada
M
M
Sugimura
T
T
D000199:Actins / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002460:Cell Line; D005353:Fibronectins / Q000235:genetics; D005796:Genes; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D011347:Procollagen / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics* / Q000302:isolation & purification; D014158:Transcription, Genetic
D000199:Actins; D005353:Fibronectins; D011347:Procollagen; D012333:RNA, Messenger