Role of enteric adenoviruses and rotaviruses in mild and severe acute enteritis.
The role of enteric-type adenoviruses and rotaviruses in mild and severe acute gastroenteritis was investigated among children younger than 5 years of age seeking treatment at an urban hospital (UH) and at a rural health center (RHC) in India. There were 330 children at the UH and 340 at the RHC; 319 and 315 age matched nondiarrheal children served as controls for the respective groups. Rotavirus was detected in 15.2% of 330 cases and 1.9% of 319 controls at the UH (P less than 0.001) and in 16.5% of 340 cases and 2.9% of 315 controls at the RHC (P less than 0.001). RV excretion was 3- to 5-fold more common in severe compared with mild diarrhea at the UH and at the RHC (P less than 0.001). The detection rate for enteric-type adenoviruses was similar in patients and controls, respectively, at the UH (0.9%; 2.5%) and RHC (3.8%; 2.5%). At the RHC adenovirus types other than 40 and 41 were excreted by 8.8% of the patients and by only 1.0% of the controls (P less than 0.001). It is possible that the diarrheagenic role of adenoviruses may not be restricted to types 40 and 41.
Bhan
M K
MK
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi.
Raj
P
P
Bhandari
N
N
Svensson
L
L
Stintzing
G
G
Prasad
A K
AK
Jayashree
S
S
Srivastava
R
R
D000260:Adenoviruses, Human / Q000302:isolation & purification*; D002675:Child, Preschool; D003681:Dehydration / Q000209:etiology; D003967:Diarrhea / Q000150:complications / Q000382:microbiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000382:microbiology; D006786:Hospitals, Urban; D006801:Humans; D007194:India; D007223:Infant; D012401:Rotavirus / Q000302:isolation & purification*; D012423:Rural Health