[Effect of the microiontophoretic application of acetylcholine on the formation of conditioned reactions in motor cortex neurons].
In alert rabbits the activity of the motor cortex neurones was recorded with simultaneous application of acetylcholine to them in the process of defensive conditioning. Conditioned reorganization, mainly of activation type, were found in 60% of neurones. In most cases conditionally reacting cells were sensitive to acetylcholine. Ionophoretic application of the transmitter promoted the formation of conditioned neuronal responses and increased them in comparison with conditioned reactions evoked in absence of acetylcholine. It is supposed that the influence of acetylcholine on conditioned cellular process is realized due to its action on the state of excitability of the cortical neurones.
Mednikova
Iu S
IuS
D000109:Acetylcholine / Q000008:administration & dosage*; D000161:Acoustic Stimulation; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D004558:Electric Stimulation; D004576:Electromyography; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D007478:Iontophoresis; D008839:Microelectrodes; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology
D000109:Acetylcholine
Vliianie mikroionoforeticheskogo podvedeniia atsetilkholina na formirovanie uslovnykh reaktsiĭ u neĭronov motornoĭ kory.