The risk of cytomegalovirus transmission by penetrating keratoplasty.
To investigate the risk of cytomegalovirus transmission by corneal transplantation, we quantitated anticytomegalovirus IgG levels of donor, preoperative, and postoperative serum samples. Of 118 patients, 79 (67%) were seropositive preoperatively. Twenty-five patients who were seronegative preoperatively received a graft from a positive donor and two (8%) seroconverted. Eleven patients who were seronegative preoperatively received a graft from a negative donor and one (9%) seroconverted. None of the patients who seroconverted had a febrile illness and all three grafts were clear.
Holland
E J
EJ
Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City 52242.
Bennett
S R
SR
Brannian
R
R
Osborne
J C
JC
Goeken
J A
JA
Krachmer
J H
JH
D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D003315:Cornea / Q000382:microbiology; D016039:Corneal Transplantation; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000635:transmission*; D006801:Humans; D007108:Immune Tolerance; D008875:Middle Aged; D012307:Risk Factors; D012698:Serologic Tests; D014019:Tissue Donors
D000914:Antibodies, Viral