[Effect of anticholinesterase preparations on the conduction of nociceptive excitation in the spinal cord].
The effect of anticholinesterases physostigmine and galanthamine on spontaneous and intraarterial bradykinin-induced bioelectrical activity in the ventrolateral tracts of the spinal cord in spinal rats was studied. Physostigmine (1, 2 and 4 micrograms) and galanthamine (25, 50 and 100 micrograms) administered intrathecally were found to produce dose-dependent inhibition both of spontaneous and induced bioelectrical activity. Atropine (1 mg/kg, intravenously) abolished the inhibitory effect of anticholinesterases.
Nemirovskiĭ
A Iu
AIu
D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001920:Bradykinin / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004347:Drug Interactions; D005702:Galantamine / Q000494:pharmacology; D009619:Nociceptors / Q000187:drug effects*; D010830:Physostigmine / Q000494:pharmacology; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D002800:Cholinesterase Inhibitors; D005702:Galantamine; D001285:Atropine; D010830:Physostigmine; D001920:Bradykinin
Vliianie antikholinésteraznykh preparatov na provedenie notsitseptivnogo vozbuzhdeniia v spinnom mozge.