Association between nonspecific bronchial hyperreactivity and superoxide anion production by polymorphonuclear leukocytes in chronic air-flow obstruction.
Inflammatory reactions are believed to be important in nonspecific bronchial hyperreactivity (BHR). To investigate the potential role for oxidant-mediated modulation of BHR, we investigated oxidative metabolism of polymorphonuclear leukocytes (PMN) from the peripheral blood in 28 nonallergic patients with chronic air-flow obstruction (CAO). No difference in O2- was found between 14 smokers and 14 ex-smokers with CAO. A significant correlation was found between the degree of BHR and O2(-)-generation of PMN after stimulation with 20 ng/ml phorbol myristate acetate, both in smokers (r = 0.59, p less than 0.01) and in ex-smokers (r = 0.79, p less than 0.01). In the light of other findings in experimental animal studies, the results suggest a direct or indirect role for O2- in the modulation of BHR. Thus, in nonallergic patients with CAO, BHR and inflammation may be linked in a similar way as in allergic patients with asthma.
Postma
D S
DS
Department of Pulmonology, State University Hospital, Groningen, The Netherlands.
Renkema
T E
TE
Noordhoek
J A
JA
Faber
H
H
Sluiter
H J
HJ
Kauffman
H
H
D000328:Adult; D000368:Aged; D000838:Anions; D001980:Bronchi / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D005541:Forced Expiratory Volume; D006632:Histamine; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D012907:Smoking; D013481:Superoxides / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014797:Vital Capacity
D000838:Anions; D013481:Superoxides; D006632:Histamine; D013755:Tetradecanoylphorbol Acetate