title: ADCC and complement-dependent lysis as immune mechanisms against EHV-1 infection in the horse.
abstract: Immunity to equine herpesvirus type 1 (EHV-1) was evaluated using sera collected from yearling horses involved in a trial of a commercial vaccine. Measurement of the ability of these sera to mediate antibody-dependent cellular cytotoxicity and complement-dependent lysis revealed that these mechanisms, although potentially important in recovery from EHV-1 infection, do not play a role in protection following vaccination.
authors.affiliation: Animal Virus Research Institute, Pirbright, Woking, Surrey.
authors.forename: A
authors.initials: A
authors.lastname: Stokes
authors.forename: R C
authors.initials: RC
authors.lastname: Wardley
mesh_terms: D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D003165:Complement System Proteins / Q000276:immunology*; D006566:Herpesviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D004861:Herpesvirus 1, Equid; D006734:Horse Diseases / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D006736:Horses; D014765:Viral Vaccines
chemical_list: D014765:Viral Vaccines; D003165:Complement System Proteins