Influence of centrally administered alpha- and gamma 2-melanocyte-stimulating hormone on hypothalamic blood flow autoregulation in the rat.
The effect of intracerebroventricularly (i.c.v.) administered alpha-melanocyte-stimulating hormone (MSH) and gamma 2-MSH on hypothalamic blood flow autoregulation was studied in anesthetized rats at different levels of standardized arterial hypotension. Autoregulation was impaired upon i.c.v. administration of 5 micrograms/kg gamma 2-MSH while alpha-MSH caused no changes. Since this effect of gamma 2-MSH was identical to that produced by i.c.v. naloxone in the same model, gamma 2-MSH may be a functional antagonist of central opioid mechanisms participating in the control of cerebral blood flow autoregulation.
Sandor
P
P
Experimental Research Department, Semmelweis University Medical School, Budapest, Hungary.
de Jong
W
W
Cox-van Put
J
J
de Wied
D
D
D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006470:Hemorrhage / Q000503:physiopathology; D006706:Homeostasis / Q000187:drug effects; D007022:Hypotension / Q000503:physiopathology; D007031:Hypothalamus / Q000098:blood supply*; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D000521:alpha-MSH / Q000494:pharmacology*
D000521:alpha-MSH; D009074:Melanocyte-Stimulating Hormones