Peptide T from human immunodeficiency virus envelope does not interact with hepatic, intestinal and colonic vasoactive intestinal peptide (VIP) receptors.
Acquired immunodeficiency syndrome (AIDS) is initiated by the attachment of the human immunodeficiency virus (HIV) to specific target cells. An octapeptide sequence contained within the envelope of HIV, peptide T, mediates the viral binding. Since there is a considerable structural homology between peptide T and VIP, it has been proposed that the VIP receptor may be the naturally occurring protein which provides the corresponding cellular attachment site. In three different models (rat intestinal epithelial cell membranes, rat liver plasma membranes and human colonic cells), we document the lack of interaction between peptide T and the VIP receptor. These observations would also exclude any pathophysiologic effect caused by the crossreactivity of peptide T or its analogues and these VIP receptors.
Nguyen
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TD
Division of Gastroenterology, Stanford University School of Medicine, CA 94305.
D000230:Adenocarcinoma; D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D003106:Colon / Q000378:metabolism*; D003110:Colonic Neoplasms; D004848:Epithelium / Q000378:metabolism; D006678:HIV / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008297:Male; D009842:Oligopeptides / Q000378:metabolism*; D015717:Peptide T; D051381:Rats; D011919:Rats, Inbred Strains; D011964:Receptors, Gastrointestinal Hormone / Q000378:metabolism*; D018005:Receptors, Vasoactive Intestinal Peptide; D011991:Receptors, Virus / Q000502:physiology*; D012191:Retroviridae Proteins / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D009842:Oligopeptides; D011964:Receptors, Gastrointestinal Hormone; D018005:Receptors, Vasoactive Intestinal Peptide; D011991:Receptors, Virus; D012191:Retroviridae Proteins; D015717:Peptide T; D014660:Vasoactive Intestinal Peptide