Evaluation of cyclosporine nephrotoxicity in rats with various renal radioactive agents.
The efficacy of different radiodiagnostic agents for demonstrating the decline in renal function from cyclosporine (CyA) nephrotoxicity was assessed in rats receiving a standard dose of the drug for 2 wk, compared with control rats. The agents included [99mTc]DTPA, [131I]hippuran, [111In]lysozyme, [99mTc]glucoheptonate (GHA), [99mTc]dimercaptosuccinate (DMS) and [111In]aminated dextran (amdex). A small dose of [99mTc]- or [111In]DTPA was administered simultaneously to normalize the results for variations in drug response from one animal to another. There were statistically significant differences in the detectability of the renal functional impairment by plasma clearance, early and 2-hr renal uptake among the different agents. However, none was clearly superior to DTPA. This conclusion is consistent with previous studies which showed a parallel decline in glomerular filtration rate (GFR) and effective renal plasma flow in acute CyA toxicity probably due primarily to vasoconstriction.
McAfee
J G
JG
Department of Radiology, SUNY Health Science Center, Syracuse.
Thomas
F D
FD
Subramanian
G
G
Roskopf
M
M
Hellwig
B
B
D000818:Animals; D003524:Cyclosporins / Q000633:toxicity*; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D007668:Kidney / Q000000981:diagnostic imaging*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D004113:Succimer; D013400:Sugar Acids; D013667:Technetium; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D016284:Technetium Tc 99m Pentetate; D014018:Tissue Distribution
D003524:Cyclosporins; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D013400:Sugar Acids; D007465:Iodohippuric Acid; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013667:Technetium; D004369:Pentetic Acid; D004113:Succimer; C100014:technetium Tc 99m gluceptate; D016284:Technetium Tc 99m Pentetate