Hormonal changes during decompression sickness.
Changes in plasma hormone levels were studied in anesthetized dogs during decompression sickness. Hormone levels were measured in 4 groups: control (no dive, n = 9); air group (air dive, ventilated with air postdive, n = 6); helium-oxygen (He-O2) group (air dive, ventilation changed to He-O2 at 30 min postdive, n = 9); nonsurvivor group (air dive, died within 30 min postdive, n = 9). Dived animals were subjected to repetitive dives until pulmonary artery pressure doubled. Plasma epinephrine (Epi) and norepinephrine (NE) concentrations rapidly increased postdive in all animals. Serum angiotensin-converting enzyme (ACE) activity increased postdive in the He-O2 group only, and these increases were small. Diving did not alter serum concentrations of cortisol, thyroxine (T4), or triiodothyronine (T3); however, T4 and T3 fell in all animals, probably as a consequence of anesthesia. He-O2 breathing did not affect concentrations of Epi, NE, cortisol, T4, T3, or serum ACE activity.
Catron
P W
PW
Thomas
L B
LB
McDermott
J J
JJ
Smallridge
R C
RC
Lake
C R
CR
Kinzer
C
C
Chernow
B
B
Flynn
E T
ET
D000818:Animals; D001794:Blood Pressure; D001831:Body Temperature; D002395:Catecholamines / Q000097:blood*; D003665:Decompression Sickness / Q000097:blood*; D004285:Dogs; D006371:Helium; D006728:Hormones / Q000097:blood*; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010100:Oxygen; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood; D013997:Time Factors
D002395:Catecholamines; D006728:Hormones; D013963:Thyroid Hormones; D006371:Helium; D007703:Peptidyl-Dipeptidase A; D010100:Oxygen; D006854:Hydrocortisone