title: [Antimicrobial activity of new beta-lactams and aminoglycosides in vitro under conditions of anaerobiosis].
abstract: Sensitivity of 135 strains of aerobic, facultative anaerobic and anaerobic asporogenous bacteria was tested in vitro with respect to 7 beta-lactam antibiotics and 4 aminoglycosides. It was shown that anaerobiosis influenced the MICs of the drugs for the majority of the strains. Under such conditions sensitivity of the aerobic and facultative anaerobic organisms to the beta-lactams increased 2-8 times. On the contrary, the MICs of the aminoglycosides for 74.6-85.1 per cent of the strains increased 2-16 times. The asporogenous anaerobic bacteria of clinical origin were highly sensitive to the beta-lactam antibiotics such as cefoxitin, cefotaxime, mezlocillin and carbenicillin whose MICs did not exceed 16-31.2 micrograms/ml.
authors.forename: L V
authors.initials: LV
authors.lastname: Bol'shakov
authors.forename: N S
authors.initials: NS
authors.lastname: Bogomolova
authors.forename: B A
authors.initials: BA
authors.lastname: Shenderov
mesh_terms: D000617:Aminoglycosides; D000693:Anaerobiosis; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001420:Bacteria, Aerobic / Q000187:drug effects; D001421:Bacteria, Anaerobic / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D047090:beta-Lactams
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D047090:beta-Lactams
vernacular_title: Antimikrobnaia aktivnost' novykh betalaktamov i aminoglikozidov in vitro v usloviiakh anaérobioza.