Changes in the histograms of nerves resulting from growth and various modalities of damage. A computer simulation.
A computer program simulates the changes in a nerve's histogram during normal growth and from various neuropathies. The program shows how a nerve's histogram will change from various percentages of fiber damage or from preferential damage to either thick or thin fibers, or from various degrees of fiber restitution, or from single-event or repetitive damage. In single-event damage, the main alteration is a preponderance of thin (regenerating) fibers. Patterns of selective fiber vulnerability are difficult to deduce from the shape of the histogram. Repetitive damage remodels the histogram to a broad unimodal fiber distribution at reduced mean caliber. Comparison of simulated changes with data from an experimental isoniazid neuropathy yielded a close match between observed changes and simulation.
Bunker
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Abteilung für Neuropathologie, Universität Göttingen, Federal Republic of Germany.
Friede
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D000818:Animals; D003198:Computer Simulation; D006801:Humans; D007538:Isoniazid; D009412:Nerve Fibers / Q000473:pathology; D009416:Nerve Regeneration; D009420:Nervous System / Q000254:growth & development; D009422:Nervous System Diseases / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D051381:Rats
D007538:Isoniazid