title: Development of cervical and vaginal squamous cell neoplasia as a late consequence of in utero exposure to diethylstilbestrol.
abstract: During the last 14 years, several articles have given contradictory reports on prevalence rates of squamous cell neoplasia of the cervix and vagina in diethylstilbestrol (DES)-exposed progeny. In 1984, the DES-Adenosis (DESAD) Project found that the incidence of cervical and vaginal intraepithelial neoplasia in DES-exposed daughters was twice as high as in a comparison group of unexposed women. This was also associated with a higher rate of herpes simplex virus and human papillomavirus infections. Possible hypotheses on the etiology of the increased incidence of squamous neoplasia are discussed.
authors.affiliation: Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030.
authors.forename: J
authors.initials: J
authors.lastname: Bornstein
authors.forename: E
authors.initials: E
authors.lastname: Adam
authors.forename: K
authors.initials: K
authors.lastname: Adler-Storthz
authors.forename: R H
authors.initials: RH
authors.lastname: Kaufman
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000453:epidemiology*; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D006561:Herpes Simplex / Q000453:epidemiology; D006801:Humans; D027383:Papillomaviridae; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014412:Tumor Virus Infections / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology*; D014625:Vaginal Neoplasms / Q000453:epidemiology*
chemical_list: D004054:Diethylstilbestrol