title: Immunohistochemical evidence for the presence of peptides derived from proenkephalin, prodynorphin and proopiomelanocortin in the guinea pig pineal gland.
abstract: By using a plethora of region-specific antisera, this light microscopic immunohistochemical study revealed that derivatives from the three opioid precursors, i.e. proenkephalin, prodynorphin and proopiomelanocortin are differentially distributed in the pineal gland of guinea pig. Various molecular forms of immunoreactive opioid peptides derived from proenkephalin or prodynorphin were present in a minority of pinealocytes as well as in nerves. In contrast to this dual distribution pattern of opioid-active peptides, the opioid-inactive derivative from proopiomelanocortin, alpha-melanocyte stimulating hormone, was exclusively present in a large proportion of pinealocytes. A multiple and differential origin and function of opioidergic pineal innervation involving sympathetic, parasympathetic and sensory components is suggested. alpha-MSH is proposed as a pineal hormone which may act in concert with melatonin to regulate pineal rhythms or may function like MSH of pituitary origin.
authors.affiliation: Department of Anatomy, Johannes Gutenberg-Universität, Mainz, Federal Republic of Germany.
authors.forename: H
authors.initials: H
authors.lastname: Schröder
authors.forename: E
authors.initials: E
authors.lastname: Weihe
authors.forename: D
authors.initials: D
authors.lastname: Nohr
authors.forename: L
authors.initials: L
authors.lastname: Vollrath
mesh_terms: D000818:Animals; D004745:Enkephalins / Q000378:metabolism; D006168:Guinea Pigs; D007150:Immunohistochemistry; D008297:Male; D010455:Peptides / Q000378:metabolism*; D010870:Pineal Gland / Q000378:metabolism*; D011333:Pro-Opiomelanocortin / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism; D000521:alpha-MSH / Q000378:metabolism
chemical_list: D004745:Enkephalins; D010455:Peptides; D011498:Protein Precursors; C029992:proenkephalin; D000521:alpha-MSH; D011333:Pro-Opiomelanocortin; C033660:preproenkephalin