title: Metastatic extramammary Paget's disease: dramatic response to combined modality treatment.
abstract: A case of extramammary Paget's disease is reported. The distinguishing features of the case are: (1) localization of the primary lesion to the scrotum, (2) development of metastases in the absence of a recognizable underlying carcinoma, and (3) response of the systemic disease to a combination of radiation therapy and chemotherapy. The histogenesis, clinical behavior, and treatment of extramammary Paget's disease are reviewed.
authors.affiliation: Department of Hematology/Oncology, University of Mississippi Medical Center, Jackson 39216.
authors.forename: L
authors.initials: L
authors.lastname: Balducci
authors.forename: M
authors.initials: M
authors.lastname: Athar
authors.forename: G F
authors.initials: GF
authors.lastname: Smith
authors.forename: T
authors.initials: T
authors.lastname: Khansur
authors.forename: D
authors.initials: D
authors.lastname: McKenzie
authors.forename: E D
authors.initials: ED
authors.lastname: Crawford
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D010145:Paget Disease, Extramammary / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D011879:Radiotherapy Dosage; D012611:Scrotum / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D013997:Time Factors
chemical_list: D008937:Mitomycins; D016685:Mitomycin; D005472:Fluorouracil