Paraneoplastic limbic encephalopathy.
Paraneoplastic limbic encephalopathy (PLE) is a remote, nonmetastatic complication of carcinoma. Neuropsychiatric symptoms consists of cognitive, affective, and behavioral changes that can predate the diagnosis of carcinoma by as much as 6 years. The most striking feature is the development of an amnestic syndrome without generalized intellectual decline. We report a case of PLE, including neuropsychological test results, and review the features of similar cases in the literature. The postulated causes and clinical implications of PLE are discussed.
Camara
E G
EG
Department of Psychiatry, Cleveland Clinic Foundation, Ohio 44106.
Chelune
G J
GJ
D018288:Carcinoma, Small Cell / Q000150:complications / Q000523:psychology; D004660:Encephalitis / Q000209:etiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008032:Limbic System; D008175:Lung Neoplasms / Q000150:complications / Q000523:psychology; D008875:Middle Aged; D009483:Neuropsychological Tests; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000523:psychology