title: Itraconazole in the treatment of acute vaginal candidiasis.
abstract: In a multicentre open prospective study itraconazole was evaluated in the treatment of acute vaginal candidiasis. Two dosage regimens were tested--200 mg twice a day for 1 day and 200 mg twice a day for 2 days. There were no statistically significant differences between these dosages, and cure rates at 7 and 28 days after treatment were 83% and 75% respectively. These are marginally lower than those produced by longer courses of oral ketoconazole (Nizoral; Janssen) and vaginal econazole nitrate but the advantages are better patient compliance and greater cost-effectiveness.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Cape Town.
authors.forename: B
authors.initials: B
authors.lastname: Bloch
authors.forename: P G
authors.initials: PG
authors.lastname: Barnard
authors.forename: G D
authors.initials: GD
authors.lastname: Burger
authors.forename: J S
authors.initials: JS
authors.lastname: Meyer
authors.forename: J R
authors.initials: JR
authors.lastname: Parkes
authors.forename: E
authors.initials: E
authors.lastname: Smythe
mesh_terms: D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D011446:Prospective Studies; D011897:Random Allocation
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole