[Inhibitory effect of interferons and tumor necrosis factor on syncytium formation by bovine leukemia virus].
The treatments of the bovine spleen cells BESp with recombinant human leukocyte interferon (HuIFN-alpha A) and human fibroblast interferon (HuIFN-beta) inhibit the syncytium formation by bovine leukemia virus (BLV) and the virus yield, depending on the IFN doses. But HuIFN-gamma did not inhibit the syncytium formation. The tumor-necrosis factor (TNF) also inhibits the syncytium formation and the virus yield, depending on the TNF doses. Furthermore, the combination of the HuIFN-alpha A with the TNF inhibits the syncytium formation more strongly than the HuIFN-alpha A alone or the TNF alone.
Imanishi
J
J
Département de Microbiologie, Université Médicale de la Préfecture de Kyoto, Japan.
Ike
H
H
Yamada
A
A
D000818:Animals; D002417:Cattle; D004357:Drug Synergism; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D001909:Leukemia Virus, Bovine / Q000187:drug effects / Q000502:physiology*; D012190:Retroviridae / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D007370:Interferon Type I; D014409:Tumor Necrosis Factor-alpha
Effet inhibiteur des interférons et du facteur de nécrose tumorale (TNF) sur la formation des syncytiums par le virus de leucémie bovine.