title: Functional interleukin 2 receptors on B cells lacking Tac antigens.
abstract: Human B lymphoblastoid line, SKW 6-4, cells were induced to IgM-secreting cells by high concentrations of interleukin 2 (IL 2). These cells were found to be unreactive with anti-Tac antibody and did not express mRNA detectable for Tac antigen. In Scatchard plot analysis, low-affinity IL 2-binding sites were found on SKW 6-4 cells. Moreover, analysis of the IL 2-binding molecules revealed ones (molecular weight 70,000 and 75,000) distinct from Tac antigen. It is conceivable that IL 2 exerts its effect through its interaction with these novel IL 2-binding molecules in SKW 6-4 cells.
authors.affiliation: Third Department of Internal Medicine, Osaka University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: O
authors.initials: O
authors.lastname: Saiki
authors.forename: S
authors.initials: S
authors.lastname: Doi
authors.forename: M
authors.initials: M
authors.lastname: Hatakeyama
authors.forename: T
authors.initials: T
authors.lastname: Doi
authors.forename: T
authors.initials: T
authors.lastname: Kono
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: M
authors.initials: M
authors.lastname: Fujii
authors.forename: K
authors.initials: K
authors.lastname: Sugamura
authors.forename: S
authors.initials: S
authors.lastname: Negoro
mesh_terms: D000954:Antigens, Surface / Q000032:analysis*; D001402:B-Lymphocytes / Q000032:analysis*; D002454:Cell Differentiation; D002460:Cell Line; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D007376:Interleukin-2 / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D011971:Receptors, Immunologic / Q000032:analysis* / Q000145:classification / Q000378:metabolism; D015375:Receptors, Interleukin-2; D011994:Recombinant Proteins / Q000378:metabolism; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7
chemical_list: D000954:Antigens, Surface; D007075:Immunoglobulin M; D007376:Interleukin-2; D012333:RNA, Messenger; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D011994:Recombinant Proteins; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7