[Role of Ca-calmodulin- and cAMP-dependent reactions in forming the cardiac cycle].
The mechanisms of regulation of calcium ion concentration in the heart muscle during cardiac cycle have been considered. A great deal of attention has been devoted to the interaction of Ca2+-calmodulin- and cAMP-dependent reactions in the heart contraction-relaxation processes. The hypothesis on the two-phase structure of cardiac cycle has been proposed. This hypothesis allows to explain some biochemical mechanisms in the positive inotropic effect of catecholamines, cardiac glycosides and caffeine.
Laptev
B I
BI
Prokop'eva
V D
VD
Bogomaz
S A
SA
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000502:physiology*; D002147:Calmodulin / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology*; D004734:Energy Metabolism; D006339:Heart Rate; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D012508:Sarcolemma / Q000502:physiology
D002147:Calmodulin; D000242:Cyclic AMP; D002118:Calcium
Rol' Ca-kal'modulin- i tsAMF-zavisimykh reaktsiĭ v formirovanii serdechnogo tsikla.