Protein kinase activity, growth and differentiation of murine erythroleukemia cells.
The addition of type 2 cAMP-dependent protein kinase stimulates division of cultured Friend erythroleukemia cells. A synthetic peptide representing the inhibitory portion of the heat stable protein kinase inhibitor protein and an inhibitor of cAMP-dependent protein kinase (N-(2-aminoethyl)-5-isoquinolinesulfonamide dihydrochloride or H-9) inhibited cell division. The latter inhibitor (H-9) induced differentiation of the cells.
Flickinger
R A
RA
Department of Biological Sciences, State University of New York, Buffalo 14260.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D000242:Cyclic AMP / Q000494:pharmacology; D007546:Isoquinolines / Q000494:pharmacology*; D004915:Leukemia, Erythroblastic, Acute; D007942:Leukemia, Experimental; D051379:Mice; D010766:Phosphorylation; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000378:metabolism*; D013449:Sulfonamides
D007546:Isoquinolines; D047428:Protein Kinase Inhibitors; D013449:Sulfonamides; C044388:N-(2-aminoethyl)-5-isoquinolinesulfonamide; D000242:Cyclic AMP; D011494:Protein Kinases