Bone biopsies and serum vitamin-D levels in patients with hip fracture.
To assess the correlation between osteoid and vitamin D in patients with a proximal femoral fracture, bone biopsies of the fracture site and the iliac crest were studied; and vitamin-D levels were measured in fasting blood taken on the day of admission. No osteomalacia was found at either site in any of the 95 patients investigated. In 65/95 patients, levels of 25-hydroxy-vitamin D (25-OHD) and 24,25-dihydroxy-vitamin D (24, 25-OH2D) were within the normal range, whereas 30/95 patients were deficient. Because there was no correlation between the amount of osteoid and vitamin-D metabolites in our patients, we concluded that osteomalacia was not a contributory factor in the pathogenesis of the hip fracture.
Eventov
I
I
Department of Orthopedics, Ichilov Hospital and Sackler School of Medicine, Tel-Aviv University, Israel.
Frisch
B
B
Alk
D
D
Eisenberg
Z
Z
Weisman
Y
Y
D015650:24,25-Dihydroxyvitamin D 3 / Q000097:blood; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D005069:Evaluation Studies as Topic; D005260:Female; D005272:Femur Neck / Q000473:pathology*; D006620:Hip Fractures / Q000097:blood* / Q000150:complications; D006801:Humans; D007085:Ilium / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000150:complications / Q000473:pathology*; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000150:complications
D014807:Vitamin D; D015650:24,25-Dihydroxyvitamin D 3