[Value of the detection of serum anti-cytomegalovirus antibodies applied to the diagnosis of recent infection].
Cytomegalovirus (CMV) infection is a major cause of morbidity in immunodepressed patients: the diagnosis is based on the demonstration of CMV viraemia and/or specific IgM and/or a significant rise in antibody titres. This study was undertaken to compare the diagnostic value of these parameters. Eighteen patients with the AIDS and CMV infection were investigated; CMV viraemia was demonstrated in 87 p. 100 and specific IgM in 23 p. 100 of cases; in 24 patients followed up for 4 months after bone marrow transplantation viraemia was demonstrated in 70 p. 100 and IgM in 54 p. 100 of cases; however, the detection of IgM was often late. In contrast, specific IgM is frequently detected in CMV infection of non-immunodepressed patients.
Harzic
M
M
Laboratoire de Bactériologie-Virologie, Hôpital Saint-Louis, Paris.
Mazeron
M C
MC
Bertrand
C
C
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000914:Antibodies, Viral / Q000032:analysis*; D016026:Bone Marrow Transplantation; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D011183:Postoperative Complications; D014766:Viremia / Q000276:immunology*
D000914:Antibodies, Viral; D007075:Immunoglobulin M
Evaluation de la détection des anticorps sériques anti-CMV appliquée au diagnostic de l'infection récente.