Fibroblast growth factor: structural and biological properties.
Basic fibroblast growth factor (FGF) and acidic FGF are two closely related peptides that are multifunctional. They control proliferation, differentiation, and various other cellular functions in cells derived from the mesoderm and the neuroectoderm. The structural properties, genomic organization, and biological functions of both peptides in vitro or in vivo are reviewed. Their marked ability to enhance formation of connective tissue and vascular capillaries, as well as their involvement in limb regeneration, suggest several possible therapeutic applications.
Gospodarowicz
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Cancer Research Institute, University of California Medical Center, San Francisco 94143.
Neufeld
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Schweigerer
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D000818:Animals; D002478:Cells, Cultured; D046508:Culture Techniques; D004347:Drug Interactions; D005109:Extracellular Matrix / Q000187:drug effects; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D011956:Receptors, Cell Surface / Q000187:drug effects; D017468:Receptors, Fibroblast Growth Factor; D013329:Structure-Activity Relationship
D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors