[Mechanisms of regulation of arterial blood pressure: role of the sympathetic nervous system and of the renin-angiotensin system in patients on a low-sodium diet].
In order to discover more about the role of the sympathetic nervous and renin-angiotensin systems in the preservation of homeostasis during chronic reductions of salt intake, blood pressure, blood catecholamines and renin activity were measured in a group of healthy subjects in normal conditions and on a salt-free diet combined with blockade of the conversion enzyme by enalapril. The results confirmed the hypothesis advanced on an earlier occasion i.e. that both hormone systems contribute to pressure during salt depletion in the initial phase, while over the long term only the renin-angiotensin system is activated though when this is inhibited, the sympathetic nervous system will take over its function.
Lembo
G
G
II Facoltà di Medicina, Università degli Studi di Napoli.
Autiero
C
C
Morganti
A
A
Ricci
A
A
Volpe
M
M
Condorelli
M
M
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004039:Diet, Sodium-Restricted; D004656:Enalapril / Q000494:pharmacology; D004837:Epinephrine / Q000097:blood; D006801:Humans; D009638:Norepinephrine / Q000097:blood; D011187:Posture; D012084:Renin-Angiotensin System; D012964:Sodium / Q000652:urine; D013564:Sympathetic Nervous System / Q000502:physiology*
D004656:Enalapril; D012964:Sodium; D009638:Norepinephrine; D004837:Epinephrine
I meccanismi della regolazione della pressione arteriosa: ruolo del sistema simpatico e di quello renina angiotensina in pazienti sottoposti a dieta iposodica.