[Mechanisms of the action of hypertonic solutions on the ionic permeability of human skin].
For human skin transcutaneous transport of I ions in vitro depends on sodium chloride-iodide concentration relations in mineral water, whereas such transport for Br ions in mainly determined by absolute concentration of sodium chloride. Optimal proportions of the salts have been specified for I and Br ions transcutaneous transport in definite concentration range. An unknown feature of the mechanism of action of hypertonic salt solutions on ionic skin permeability has been identified. The results are analyzed from the point of view of the ion pairs conception.
Tereshin
S Iu
SIu
Serov
S I
SI
D001965:Bromides / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D006982:Hypertonic Solutions; D066298:In Vitro Techniques; D007454:Iodides / Q000494:pharmacology*; D008900:Mineral Waters; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D012869:Skin Absorption / Q000187:drug effects*; D012964:Sodium / Q000494:pharmacology*; D017670:Sodium Compounds; D012974:Sodium Iodide / Q000494:pharmacology*
D001965:Bromides; D006982:Hypertonic Solutions; D007454:Iodides; D008900:Mineral Waters; D012462:Saline Solution, Hypertonic; D017670:Sodium Compounds; D012964:Sodium; D012974:Sodium Iodide; C027938:sodium bromide
Nekotorye mekhanizmy deĭstviia gipertonicheskikh rastvorov na ionnuiu pronitsaemost kozhi cheloveka.