Adjunctive imipramine maintenance treatment in schizophrenic patients with remitted postpsychotic depression.
Ten patients with histories of postpsychotic depression responsive to adjunctive imipramine added to fluphenazine decanoate and benztropine underwent a double-blind trial of imipramine discontinuation 6 months after responding to the adjunctive imipramine. Discontinuation of imipramine was associated with depressive relapse.
Siris
S G
SG
Hillside Hospital Division, Long Island Jewish Medical Center, New York.
Cutler
J
J
Owen
K
K
Mason
S
S
Gingerich
S
S
Lang
M P
MP
D000328:Adult; D001590:Benztropine / Q000627:therapeutic use; D003866:Depressive Disorder / Q000150:complications* / Q000188:drug therapy; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005476:Fluphenazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008875:Middle Aged; D011618:Psychotic Disorders / Q000150:complications* / Q000188:drug therapy; D014149:Tranquilizing Agents / Q000627:therapeutic use
D014149:Tranquilizing Agents; D001590:Benztropine; C011825:fluphenazine depot; D007099:Imipramine; D005476:Fluphenazine