Comparison of fluconazole and amphotericin B in treating histoplasmosis in immunosuppressed mice.
Fluconazole (UK-49,858) was compared with amphotericin B in treating histoplasmosis in female AKR mice immunosuppressed with either cyclophosphamide or cortisone. Both drugs protected animals from a lethal challenge with Histoplasma capsulatum, but neither regimen resulted in cures since viable organisms were cultured from spleens of survivors.
Kobayashi
G S
GS
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri 63110.
Travis
S J
SJ
Medoff
G
G
D000666:Amphotericin B / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D003520:Cyclophosphamide; D005260:Female; D015725:Fluconazole; D006660:Histoplasmosis / Q000188:drug therapy*; D006854:Hydrocortisone / Q000494:pharmacology; D007165:Immunosuppression Therapy; D051379:Mice; D008806:Mice, Inbred AKR; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; D000666:Amphotericin B; D003520:Cyclophosphamide; D015725:Fluconazole; D006854:Hydrocortisone