title: Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on Epstein-Barr virus (EBV)-infected cells.
abstract: We have examined if 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances soft agar clonability in Epstein-Barr virus (EBV)-infected cells on the basis of interaction between EBV and TPA. When primary human cord blood lymphocytes (HUCLs) were exposed to two different strains of EBV (B95-8 and NPC-KT) and seeded in soft agar medium containing TPA (0.25 ng/ml), it was observed that the number of transformed colonies increased. However, TPA did not enhance the number of colonies in two EBV genome-positive epithelial hybrid cell lines (NPC-KT and D98/HR-1).
authors.forename: T
authors.initials: T
authors.lastname: Takimoto
authors.forename: S
authors.initials: S
authors.lastname: Ishikawa
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
mesh_terms: D002460:Cell Line; D003043:Cocarcinogenesis; D004854:Herpesvirus 4, Human; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000209:etiology*; D013755:Tetradecanoylphorbol Acetate / Q000009:adverse effects*; D014412:Tumor Virus Infections / Q000209:etiology*
chemical_list: D013755:Tetradecanoylphorbol Acetate