Adenoviral control regions activated by E1A and the cAMP response element bind to the same factor.
Transcription of adenoviral early genes is activated by viral E1A gene products. Four of the five early genes contain sequence homologies to the cAMP-inducible element identified in cellular genes. Co-purification and competition assays demonstrated that the adenovirus and cAMP-inducible transcriptional control regions bind the same factor or factors. Since the binding sites map to regions necessary for transcription of the three adenoviral early genes whose control regions were analyzed, it is likely that the activities play a role in their transcription.
Hardy
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Department of Molecular Biology, Princeton University, NJ 08544.
Shenk
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D017456:Adenovirus Early Proteins; D000260:Adenoviruses, Human / Q000187:drug effects / Q000235:genetics*; D000957:Antigens, Viral, Tumor / Q000235:genetics*; D001483:Base Sequence; D000242:Cyclic AMP / Q000494:pharmacology*; D005786:Gene Expression Regulation; D005796:Genes; D005814:Genes, Viral; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000235:genetics* / Q000502:physiology; D014158:Transcription, Genetic / Q000187:drug effects
D017456:Adenovirus Early Proteins; D000957:Antigens, Viral, Tumor; D009856:Oncogene Proteins, Viral; D000242:Cyclic AMP