[Determination of haplotypes of DNA markers linked to the mucoviscidosis locus: detection of heterozygotes].
Linked DNA probes have been used in three families presenting an affected child with cystic fibrosis. The strategy used for the determination of haplotypes associated with parental normal and mutated genes is presented as well as its application to the detection of cystic fibrosis carriers among healthy children.
Vasseur
F
F
Service de Génétique, Faculté de Médecine, Lille.
Fontaine
F
F
Savary
J B
JB
Deminatti
M M
MM
D002648:Child; D002874:Chromosome Mapping; D003550:Cystic Fibrosis / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D004262:DNA Restriction Enzymes / Q000032:analysis; D005260:Female; D006580:Genetic Carrier Screening; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D008297:Male; D010375:Pedigree
D005819:Genetic Markers; D004247:DNA; D004262:DNA Restriction Enzymes
Etablissement des haplotypes des marqueurs d'ADN proches du locus de la mucoviscidose: détection des hétérozygotes.