Antiviral activity of uridine 5'-diphosphate glucose analogues against some enveloped viruses in cell culture.
Twenty five analogues of uridine 5'-diphosphate glucose were screened against herpes simplex type 2, vaccinia virus, Sindbis virus and African swine fever virus. After screening, the compound 5'-[[[[(2",3",4",6"-tetra-O-benzoyl-alpha-D- glucopyranosyl)oxi]carbonyl]amino]sulfonyl]uridine (2), the synthesis of which has been reported (Camarasa et al., J. Med. Chem. 28, 40-46, 1985), was selected for further study. This compound showed in vitro activity against all viruses tested. The replication of herpes virus type 2 and African swine fever virus was completely inhibited at 100 micrograms/ml and 150 micrograms/ml respectively; vaccinia virus and Sindbis virus were inhibited to a lesser extent. The compound may inhibit several steps in the viral replication process.
Gil-Fernández
G
G
Centro de Investigaciones Biológicas, Madrid, Spain.
Pérez
S
S
Vilas
P
P
Pérez
C
C
de las Heras
F G
FG
García Gancedo
A
A
D000358:African Swine Fever Virus / Q000187:drug effects; D000818:Animals; D000998:Antiviral Agents; D018139:Simplexvirus / Q000187:drug effects; D012845:Sindbis Virus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014532:Uridine Diphosphate Glucose / Q000031:analogs & derivatives / Q000494:pharmacology*; D014539:Uridine Diphosphate Sugars / Q000494:pharmacology*; D014616:Vaccinia virus / Q000187:drug effects; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D014539:Uridine Diphosphate Sugars; D014532:Uridine Diphosphate Glucose