The sign of Leser-Trélat associated with carcinoma of the stomach.
The sign of Leser-Trélat, which refers to the sudden appearance and rapid increase in size and number of seborrheic keratosis associated with a visceral malignant tumor, is very uncommon. This case concerns a 54-yr-old woman presenting with Leser-Trélat's sign associated with advanced gastric cancer. Seborrheic keratosis faded after resection of the tumor, but returned when the cancer recurred. At that time, 24-h urinary excretion of epidermal growth factor determined by radioreceptor assay was slightly elevated. Epidermal growth factor may play a part in the development of Leser-Trélat's sign.
Kameya
S
S
Third Department of Internal Medicine, Aichi Medical University, Japan.
Noda
A
A
Isobe
E
E
Watanabe
T
T
D002288:Adenocarcinoma, Mucinous / Q000150:complications* / Q000473:pathology / Q000601:surgery; D012628:Dermatitis, Seborrheic / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007642:Keratosis / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery