Spontaneous production of interleukin-2 and interleukin-3 by spleen cells from mice infected with mouse hepatitis virus type 4.
Spleen cells from mice, 4 to 60 days after infection with mouse hepatitis virus type 4, produced interleukin-2, as well as interleukin-3, in the absence of exogenous stimulants in vitro. This unique lymphokine production by mouse hepatitis virus type 4 infection was controlled by host genes.
Kyuwa
S
S
Department of Animal Pathology, University of Tokyo, Japan.
Yamaguchi
K
K
Hayami
M
M
Hilgers
J
J
Fujiwara
K
K
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D006524:Hepatitis, Viral, Animal / Q000235:genetics / Q000276:immunology*; D007376:Interleukin-2 / Q000096:biosynthesis*; D007377:Interleukin-3 / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D006517:Murine hepatitis virus / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000276:immunology*
D007376:Interleukin-2; D007377:Interleukin-3