Veno-occlusive disease of the liver following chemotherapy with mitomycin C and doxorubicin.
A 54-year-old woman with metastatic breast cancer developed veno-occlusive disease of the liver following chemotherapy with mitomycin C and doxorubicin. The dose of mitomycin C received by this patient was much lower than that previously described to cause this complication. As both these drugs are used widely physicians should be aware of this complication.
Craft
P S
PS
Dept of Medical Oncology, Woden Valley Hospital, ACT.
Pembrey
R G
RG
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000188:drug therapy*; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000009:adverse effects; D005260:Female; D006503:Hepatic Veins / Q000473:pathology; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000009:adverse effects
D008937:Mitomycins; D016685:Mitomycin; D004317:Doxorubicin