[Clinical and immune-modulating effects of the treatment with unsaturated fatty acids in atopic dermatitis].
The metabolism of essential unsaturated fatty acids seems to show changes in patients with atopic dermatitis (AD). A defect or a deficiency of a Delta-6-Desaturase, which transforms cis-linoleic acid into gamma-linolenic-acid will be discussed. We examined the influence of a treatment with unsaturated fatty acids on clinical phenotype and the surface antigens of lymphocytes in peripheral blood. Prolonged recurrence free intervals as well as a faster ability to control relapse were established. Dysbalance in the lymphocytic system was able to be positively influenced. We found an increase of Leu 2 a-antigen carrying T-suppressor-lymphocytes and of the Leu 3+8+- antigen carrying subpopulation of T-helper-lymphocytes, which are responsible for activation of precursor T-suppressor cells into.
Wehrmann
W
W
Universitäts-Hautklinik und Poliklinik Bonn.
Niedecken
H
H
Bauer
R
R
D000293:Adolescent; D000328:Adult; D003876:Dermatitis, Atopic / Q000276:immunology / Q000628:therapy*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007121:Immunocompetence / Q000187:drug effects*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage*; D008042:Linolenic Acids / Q000008:administration & dosage*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology; D017965:gamma-Linolenic Acid
D004042:Dietary Fats, Unsaturated; D008041:Linoleic Acids; D008042:Linolenic Acids; D017965:gamma-Linolenic Acid; D019787:Linoleic Acid
Klinische und immunmodulatorische Effekte einer Behandlung mit ungesättigten Fettsäuren bei atopischer Dermatitis.