Glial brain tumors lack microvascular adrenergic receptors.
In human and animal brain microvessels beta-adrenergic receptors have been identified which are suggested to subserve the regulation of capillary function in both physiological and pathological conditions. Brain tumors are supplied by vessels that differ from those supplying normal cerebral tissue in various structural and functional parameters. In order to study the characteristics of brain tumor microcirculation, we have investigated the presence of beta-adrenergic receptors in capillaries isolated from different types of neoplasms using the specific radioligand 125I-iodocyanopindolol (ICYP). The microvessels were isolated and prepared by albumin flotation and glass bead filtration from normal and pathological tissues. No ICYP-specific binding was detected in the microvessels of tumors of glial origin, while capillaries obtained from meningiomas and neurinomas showed, like the normal brain, a specific binding of the radioligand. The data indicate that the regulation of capillary function in glial tumors differs from that of normal cerebral tissue and extraparenchymal tumors, thus indicating an impaired control of the vascular permeability.
Magnoni
M S
MS
Institute of Pharmacological Sciences, Medical School, University of Milan, Italy.
Frattola
L
L
Piolti
R
R
Govoni
S
S
Kobayashi
H
H
Trabucchi
M
M
D001932:Brain Neoplasms / Q000098:blood supply*; D002536:Cerebral Arteries / Q000473:pathology*; D005910:Glioma / Q000098:blood supply; D006801:Humans; D020120:Iodocyanopindolol; D008577:Meningeal Neoplasms / Q000098:blood supply; D008579:Meningioma / Q000098:blood supply; D008833:Microcirculation / Q000473:pathology; D009442:Neurilemmoma / Q000098:blood supply; D009837:Oligodendroglioma / Q000098:blood supply; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D011943:Receptors, Adrenergic, beta; D020120:Iodocyanopindolol; D010869:Pindolol