Heterophyle antibodies causing false positive radio-immunoassay results. A case report.
A case report of falsely elevated serum hormone values measured by radio-immunoassay (RIA) is described. The radio-immunoassays concerned have a first antibody raised in rabbits and mostly a separation technique based on a second antibody-solid phase system. The presence of heterophyle (anti-rabbit) antibodies in patients' serum is proved.
Smitz
J
J
University Hospital and Medical School, Brussel, Belgium.
Foulon
W
W
Heip
J
J
Naaktgeboren
N
N
Van Steirteghem
A
A
D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000328:Adult; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D003429:Cross Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D011247:Pregnancy; D011259:Pregnancy Tests, Immunologic / Q000379:methods*; D011817:Rabbits; D011863:Radioimmunoassay
D000906:Antibodies; D000324:Adrenocorticotropic Hormone