title: Placental protein 10 (PP10) in the serum of patients with trophoblastic and nontrophoblastic gynaecological tumours.
abstract: Serum levels of placental protein 10 (PP10) were measured by radioimmunoassay in patients with trophoblastic (n = 23) and non-trophoblastic (n = 122) gynaecological tumours before, during and after treatment. Elevated levels (greater than 2.0 micrograms/l) were found in 96% of patients with an untreated trophoblastic tumour, and in 22%, 20% and 12% of patients with endometrial, cervical and ovarian carcinoma, respectively. After treatment the levels fell in patients with trophoblastic disease. Although PP10 may be tumour-associated in such cases, it is premature to assume any significance for PP10 as a tumour marker in clinical practice, because changes in serum hCG levels are much more informative.
authors.affiliation: Department I of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Tiitinen
authors.forename: G N
authors.initials: GN
authors.lastname: Than
authors.forename: K
authors.initials: K
authors.lastname: Iino
authors.forename: H
authors.initials: H
authors.lastname: Halila
authors.forename: M
authors.initials: M
authors.lastname: Seppälä
mesh_terms: D005260:Female; D005833:Genital Neoplasms, Female / Q000097:blood*; D006023:Glycoproteins; D006801:Humans; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D011863:Radioimmunoassay; D014328:Trophoblastic Neoplasms / Q000097:blood*; D014594:Uterine Neoplasms / Q000097:blood*
chemical_list: D006023:Glycoproteins; D011257:Pregnancy Proteins