Recent insertion of an Alu sequence in the beta-globin gene cluster of the gorilla.
We present the nucleotide sequence of a new Alu family member that lies between the delta- and beta-globin genes in gorilla DNA. The sequence exhibits 91% similarity with a consensus sequence of the Alu family. It is flanked by a perfect repetition of a 16-nucleotide target sequence and terminates with 24 adenylic residues. As this sequence is absent at this locus in other primate DNAs, its insertion occurred less than 8 million years ago, thus supporting the idea that Alu sequences are still mobile elements in the hominoid genome.
Trabuchet
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Département de Biologie Générale et Appliquée Claude Bernard-Lyon, Villeurbanne, France.
Chebloune
Y
Y
Savatier
P
P
Lachuer
J
J
Faure
C
C
Verdier
G
G
Nigon
V M
VM
D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D004262:DNA Restriction Enzymes; D004251:DNA Transposable Elements; D005796:Genes; D005914:Globins / Q000235:genetics*; D006071:Gorilla gorilla / Q000235:genetics*; D008969:Molecular Sequence Data
D004251:DNA Transposable Elements; D005914:Globins; D004262:DNA Restriction Enzymes