[Endogenous MMTV in the normal mammary gland and in dimethylanthracene-induced mammary cancer in BALB/c mice].
Immunization of DMBA-treated mice by the glycoprotein fraction from mammary glands of mice BALB/c did not decrease the frequencies of induction of mammary tumors. This is in contrast to the results obtained during immunization by the formaldehyde treated preparation of Mouse Mammary Tumor Virus (MMTV). EcoRI and HindIII cleaved DNA from the DMBA-induced mammary tumors did not contain the additional virus specific fragments. In mammary tumors the expression of p27 MMTV was registered in contrast to normal mammary glands and mammary epithelium cultures in which the proteins of MMTV are not expressed even after induction.
Komarova
E A
EA
Kriukova
I N
IN
Chernov
M V
MV
Kazarov
A R
AR
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002472:Cell Transformation, Viral; D005260:Female; D005814:Genes, Viral; D008321:Mammary Glands, Animal / Q000382:microbiology*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics / Q000382:microbiology*; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D014764:Viral Proteins / Q000235:genetics
D014764:Viral Proteins; D015127:9,10-Dimethyl-1,2-benzanthracene
Endogennye MMTV v normal'noĭ molochnoĭ zheleze i indutsirovannom dimetilbenzantratsenom kantserogeneze molochnoĭ zhelezy mysheĭ BALB/c.