[Effect of opiate agonists administered intrathecally on the behavioral and hemodynamic manifestations of pain].
An agonist of mu-opiate receptors, D-Ala2-Gly-ol5-enkephalin (DAGO, 0.5 mcg), administered intrathecally, was found to inhibit behavioral and hemodynamic reactions induced by thermal and electrical stimulation of conscious male rats. D-Ala2-D-Leu-enkephalin (DADL, 0.5 mcg), acting on delta-receptors, was shown to potentiate nociceptive shifts of arterial blood pressure. Phencyclidine and bremazocine failed to exert any significant effect on the opioidergic mechanisms of the spinal cord.
Zaĭtsev
A A
AA
Petriaevskaia
N V
NV
Khvan
A A
AA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001575:Benzomorphans / Q000008:administration & dosage / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004743:Enkephalin, Leucine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine; D004745:Enkephalins / Q000008:administration & dosage / Q000494:pharmacology; D006358:Hot Temperature / Q000009:adverse effects; D007278:Injections, Spinal; D008297:Male; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D010622:Phencyclidine / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects*
D001575:Benzomorphans; D004745:Enkephalins; D011957:Receptors, Opioid; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C027248:bremazocine; D010622:Phencyclidine
Vliianie opiatnykh agonistov pri ikh intratekal'nom vvedenii na povedencheskie i gemodinamicheskie proiavlenbiia boli.