title: Malignant progression of laryngeal papilloma associated with human papilloma virus type 6 (HPV-6) DNA.
abstract: A case of laryngeal squamous papilloma in the early stages of development showed histological features suggestive of virus infection. Five years later positive evidence of HPV-6 infection was obtained at a time when the lesion had developed into a squamous cell carcinoma. It is concluded that this case represents a complete example of the virus to papilloma to carcinoma sequence, and as far as is known, is the first reported case of its kind in the larynx.
authors.affiliation: Department of Otolaryngology, Manchester Royal Infirmary, Christie Hospital and Holt Radium Institute.
authors.forename: A P
authors.initials: AP
authors.lastname: Zarod
authors.forename: J D
authors.initials: JD
authors.lastname: Rutherford
authors.forename: G
authors.initials: G
authors.lastname: Corbitt
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000032:analysis / Q000382:microbiology / Q000473:pathology*; D010212:Papilloma / Q000032:analysis / Q000382:microbiology / Q000473:pathology*; D027383:Papillomaviridae / Q000302:isolation & purification; D014412:Tumor Virus Infections / Q000150:complications / Q000473:pathology*
chemical_list: D004279:DNA, Viral