title: [Cells of patients with ataxia telangiectasia show a normal capacity of radio-induced reactivation of damaged HSV-1 virus].
abstract: Herpes Simplex Virus (HSV-1) was used to probe the expression of enhanced reactivation (ER) in cells from patients with ataxia telangiectasia (AT). The survival of UV-irradiated HSV-1 was increased as a result of UV- or X-preirradiation of both AT and normal cells. This result contrasts with our previous observation showing that contrary to normal cells AT cells are deficient for ER of a single-stranded DNA parvovirus. A difference between the molecular processes underlying ER of single- and double-stranded DNA viruses might explain these results.
authors.affiliation: MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, United Kingdom.
authors.forename: G
authors.initials: G
authors.lastname: Hilgers
authors.forename: P J
authors.initials: PJ
authors.lastname: Abrahams
authors.forename: R
authors.initials: R
authors.lastname: Schouten
authors.forename: J J
authors.initials: JJ
authors.lastname: Cornelis
authors.forename: A R
authors.initials: AR
authors.lastname: Lehmann
authors.forename: A J
authors.initials: AJ
authors.lastname: Van der Eb
authors.forename: J
authors.initials: J
authors.lastname: Rommelaere
mesh_terms: D000818:Animals; D001260:Ataxia Telangiectasia / Q000382:microbiology / Q000473:pathology*; D004277:DNA, Single-Stranded / Q000528:radiation effects; D004279:DNA, Viral / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D018139:Simplexvirus / Q000254:growth & development / Q000528:radiation effects*; D014775:Virus Activation
chemical_list: D004277:DNA, Single-Stranded; D004279:DNA, Viral
vernacular_title: Les cellules de patients atteints d'ataxia telangiectasia manifestent une capacité normale de réactivation radioinduite du virus HSV-I endommagé.