Influence of oestradiol on alpha 2-adrenoceptor binding sites on intact platelets of young male volunteers.
The specific binding (Bmax) of (3H-methyl)yohimbine to alpha 2-adrenoceptor binding sites on intact platelets was increased by 43% in 6 out of 7 young male volunteers 4 days after a single i.m. injection of 10 mg sustained release oestradiol, and it had returned to the starting value 4 weeks after drug administration. Mean plasma oestradiol was 331 pg/ml on Day 4 and it was within the pre-treatment control range of 19 pg/ml 4 weeks after the injection. A close correlation between the post-injection plasma oestradiol concentration and the increase in alpha 2-adrenoceptor binding sites on intact platelets was not found.
Reimann
I W
IW
Humanpharmakologisches Institut, CIBA-GEIGY, Tübingen, Federal Republic of Germany.
Britzelmeier
C
C
Haber
P
P
Wollmann
H
H
Antonin
K H
KH
Bieck
P R
PR
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D004958:Estradiol / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000378:metabolism; D015016:Yohimbine
D011942:Receptors, Adrenergic, alpha; D015016:Yohimbine; D004958:Estradiol