Fluconazole penetration into cerebrospinal fluid in humans.
One hour after intravenous doses of 50 mg/d fluconazole for 6 days or 100 mg/d for seven days to healthy subjects, the cerebrospinal fluid concentrations of fluconazole were 1.26 mg/L and 2.74 mg/L, respectively. These values were approximately 52% and 62% those of serum. Four patients with an initial clinical diagnosis of meningitis also had significant concentrations of fluconazole in the cerebrospinal fluid.
Foulds
G
G
Central Research Division, Pfizer Inc., Groton, Connecticut 06340.
Brennan
D R
DR
Wajszczuk
C
C
Catanzaro
A
A
Garg
D C
DC
Knopf
W
W
Rinaldi
M
M
Weidler
D J
DJ
D015725:Fluconazole; D006207:Half-Life; D006801:Humans; D007262:Infusions, Intravenous; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D014230:Triazoles / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid* / Q000494:pharmacology
D014230:Triazoles; D015725:Fluconazole