Effect of recombinant human growth hormone therapy on bone and clinical parameters in girls with Turner's syndrome. The Spanish Collaborative Group.
Forty-eight girls with Turner's syndrome were assigned to one of three treatments; recombinant human growth hormone (rhGH) alone, rhGH plus oxandrolone, and rhGH plus ethinyloestradiol. Treatment with rhGH alone or in combination with oxandrolone induced catch-up growth. Older girls treated with rhGH plus ethinyloestradiol showed less marked improvement. The gain in height was associated with a gain in bone diameter and cortical thickness (reflecting increased bone mass). There was a rapid loss of subcutaneous fat. These effects of growth hormone are similar to those observed in patients with growth hormone deficiency.
Ferrández
A
A
Endocrine Unit, Children's Hospital, Zaragoza, Spain.
Mayayo
E
E
Arnal
J M
JM
García
C
C
Buñuel
C
C
Lasarte
J J
JJ
Anton
R
R
Puyuelo
P
P
D000293:Adolescent; D001846:Bone Development / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy*; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D010074:Oxandrolone / Q000627:therapeutic use; D011994:Recombinant Proteins; D012885:Skinfold Thickness; D014424:Turner Syndrome / Q000150:complications*
D011994:Recombinant Proteins; D004997:Ethinyl Estradiol; D010074:Oxandrolone; D013006:Growth Hormone