[Phosphate inhibition of the conversion of ribose-1-phosphate--a product of purine nucleoside phosphorylase splitting in the phosphoribomutase reaction].
Different phosphate concentrations were studied for their effect on the degradation of adenosine by rat liver homogenates. It is shown that phosphate considerably inhibits the phosphoribomutase reaction without a significant effect on adenosine deaminase and purine nucleoside phosphorylase activities, that leads to the ribose-1-phosphate accumulation and to the disturbance of nucleoside utilization in reactions of the pentose phosphate pathway. It is supposed that the inhibition of the phosphoribomutase reaction by phosphate is important for regulation of nucleoside and nucleotide formation in a cell.
Golovatskiĭ
I D
ID
Tsegel'skiĭ
A A
AA
D000241:Adenosine / Q000378:metabolism; D000818:Animals; D003864:Depression, Chemical; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D010428:Pentosephosphates / Q000378:metabolism*; D010430:Pentosyltransferases / Q000378:metabolism*; D010710:Phosphates / Q000494:pharmacology*; D010770:Phosphotransferases / Q000378:metabolism*; D011683:Purine-Nucleoside Phosphorylase / Q000378:metabolism*; D051381:Rats; D012267:Ribosemonophosphates / Q000378:metabolism*
D010428:Pentosephosphates; D010710:Phosphates; D012267:Ribosemonophosphates; C031154:ribose 1-phosphate; D010430:Pentosyltransferases; D011683:Purine-Nucleoside Phosphorylase; D010770:Phosphotransferases; C036179:phosphoribomutase; D000241:Adenosine
Tormozhenie fosfatom prevrashcheniia ribozo-1-fosfata--produkta purinnukleozidfosforilaznogo rasshchepleniia v fosforibomutaznoĭ reaktsii.