title: [Hepatocyte receptors for polymerized albumin. Experimental study on isolated hepatocytes and in vivo animals].
abstract: In the present work receptors for polymerized rat serum albumin (P-RSA) were studied by incubation of radiolabelled polymers with rat hepatocytes isolated with mechanical techniques. Isolated rat hepatocytes showed a receptor activity for polymerized albumin and such a membrane receptor seems to be controlled by the cellular cytoskeleton. During rat total body scintigraphy receptor expression was detected exclusively in the liver. These observations support the hypothesis of a selective receptor activity of the liver cells for polymerized albumin. To confirm our results, further studies were performed on rat bile, after 125I-P-RSA infusion in vivo.
authors.affiliation: Università di Padova, Istituto di Medicina Clinica, Ospedale Civile di Padova.
authors.forename: A
authors.initials: A
authors.lastname: Trevisan
authors.forename: R
authors.initials: R
authors.lastname: Cavigli
authors.forename: D
authors.initials: D
authors.lastname: Stenico
authors.forename: D
authors.initials: D
authors.lastname: Casara
authors.forename: C
authors.initials: C
authors.lastname: Pasquali
authors.forename: C
authors.initials: C
authors.lastname: Capri
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D007457:Iodine Radioisotopes; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism*; D011877:Radionuclide Imaging; D051381:Rats; D017457:Receptors, Albumin; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D007457:Iodine Radioisotopes; D017457:Receptors, Albumin; D011956:Receptors, Cell Surface
vernacular_title: Recettori epatocitari per albumina polimerica. Studio sperimentale su epatociti isolati ed animali in vivo.