Suppression of active collagenase from calcified lapine synovium by Arteparon.
Collagenase has been implicated in the pathogenesis of several arthropathies. Arteparon [glycos-aminoglycan (GAG) polysulfate] is a proteinase inhibitor that is being investigated as a therapeutic agent in osteoarthritis. We found that cultures of calcified lapine synovium release collagenase, one tenth of which is already activated. Normal synovium produces no active collagenase. GAG polysulfate suppresses the amount of active collagenase by one half. GAG polysulfate may interfere with the activation process of collagenase.
Halverson
P B
PB
Division of Rheumatology, Medical College of Wisconsin, Milwaukee.
Cheung
H S
HS
Struve
J
J
McCarty
D J
DJ
D000818:Animals; D002114:Calcinosis / Q000201:enzymology*; D046508:Culture Techniques; D004789:Enzyme Activation / Q000187:drug effects; D006025:Glycosaminoglycans / Q000494:pharmacology*; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors*; D011817:Rabbits; D013583:Synovial Membrane / Q000187:drug effects / Q000201:enzymology*
D006025:Glycosaminoglycans; C010034:Arteparon; D003012:Microbial Collagenase