title: The signal transducing system coupled to serotonin-S2 receptors.
abstract: The signal transducing system coupled to the serotonin-S2 receptor on platelets involves metabolism of inositol-containing phospholipid, elevation of intracellular free Ca2+ and activation of protein kinase C. Evidence for coupling of the serotonin-S2 receptor to the same signal transducing system in brain and smooth muscle tissue is reviewed.
authors.affiliation: Department of Biochemistry, Janssen Pharmaceutica Research Laboratories, Beerse, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: de Chaffoy de Courcelles
authors.forename: J E
authors.initials: JE
authors.lastname: Leysen
authors.forename: F
authors.initials: F
authors.lastname: de Clerck
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism / Q000502:physiology; D001921:Brain / Q000378:metabolism / Q000502:physiology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism / Q000502:physiology*
chemical_list: D010716:Phosphatidylinositols; D011985:Receptors, Serotonin