Effects of ginsenosides, lectins and Momordica charantia insulin-like peptide on corticosterone production by isolated rat adrenal cells.
Ginsenosides Rb1, Rb2, Rc and Rg1 inhibited steroidogenesis induced by a maximally active dose of corticotropin in isolated rat adrenal cells. The galactose-binding lectins from Momordica charantia seeds and Trichosanthes kirilowii tubers and mannose-binding concanavalin A did not affect basal corticosterone production. The lectins potentiated steroidogenesis induced by a submaximal dose of corticotropin but were without effect on steroidogenesis induced by a maximally active dose of corticotropin. Momordica charantia insulin-like peptide did not affect steroidogenesis.
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Department of Biochemistry, Chinese University of Hong Kong Shatin, N.T.
Li
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Yeung
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D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D003345:Corticosterone / Q000096:biosynthesis*; D036145:Ginsenosides; D007328:Insulin / Q000494:pharmacology; D037102:Lectins / Q000494:pharmacology*; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D037121:Plant Lectins; D010946:Plants, Medicinal / Q000032:analysis*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012503:Saponins / Q000494:pharmacology*
D036145:Ginsenosides; D007328:Insulin; D037102:Lectins; D010455:Peptides; D037121:Plant Lectins; D012503:Saponins; D003208:Concanavalin A; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone