title: The nucleotide sequence of human rhinovirus 1B: molecular relationships within the rhinovirus genus.
abstract: We have determined the complete nucleotide sequence of human rhinovirus 1B and made comparisons with other rhinoviruses. Extensive homology was found with serotypes 2 and 89 but the similarity to serotype 14 was considerably less. Rhinovirus-specific characteristics have been noted, in particular the length of the 5' non-coding region and the pattern of codon usage, and these may be sufficient to define the rhinoviruses as a distinct genus rather than being considered as members of the enteroviruses as has been suggested previously.
authors.affiliation: Department of Biology, University of Essex, Colchester, U.K.
authors.forename: P J
authors.initials: PJ
authors.lastname: Hughes
authors.forename: C
authors.initials: C
authors.lastname: North
authors.forename: C H
authors.initials: CH
authors.lastname: Jellis
authors.forename: P D
authors.initials: PD
authors.lastname: Minor
authors.forename: G
authors.initials: G
authors.lastname: Stanway
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D003062:Codon / Q000235:genetics; D004247:DNA / Q000235:genetics; D004770:Enterovirus / Q000235:genetics; D005814:Genes, Viral; D006801:Humans; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics*; D012229:Rhinovirus / Q000145:classification / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D003062:Codon; D012367:RNA, Viral; D014764:Viral Proteins; D004247:DNA