Cyclopia and congenital cytomegalovirus infection.
We describe the first documented association of congenital cytomegalovirus (CMV) infection and cyclopia. A previous report has suggested that any infant with congenital ocular defects should be investigated for CMV infection [Frenkel et al, 1980]. Our case underlines this suggestion and questions a teratogenic role for CMV in cyclopiaholoprosencephaly. More documented cases may help clarify the relationship of transplacental CMV infection to the holoprosencephaly developmental field defect, including cyclopia.
Byrne
P J
PJ
Department of Pediatrics, St. Josephs Hospital, London, Ontario, Canada.
Silver
M M
MM
Gilbert
J M
JM
Cadera
W
W
Tanswell
A K
AK
D000015:Abnormalities, Multiple / Q000209:etiology; D001921:Brain / Q000002:abnormalities*; D002540:Cerebral Cortex / Q000002:abnormalities; D003586:Cytomegalovirus Infections / Q000151:congenital*; D005124:Eye Abnormalities; D005145:Face / Q000002:abnormalities; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012886:Skull / Q000002:abnormalities