Potentiation of small cell lung cancer-related SIADH by trifluoperazine.
The syndrome of inappropriate anti-diuretic hormone secretion (SIADH) is a feature of approximately 7% of cases of small cell lung cancer (SCLC). The elaboration of peptide hormones by this tumour is well recognised and cerebral oedema resulting from inappropriate ADH secretion may be a life-threatening complication of this illness, requiring prompt intervention. We report a patient with SCLC who presented with SIADH which worsened abruptly each time he was treated with trifluoperazine for a co-existing psychosis.
Kennedy
M J
MJ
Department of Haematology/Oncology, St. James's Hospital, Dublin, Ireland.
Shelley
R K
RK
Daly
P A
PA
D018288:Carcinoma, Small Cell / Q000378:metabolism*; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000150:complications / Q000209:etiology; D008175:Lung Neoplasms / Q000150:complications* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000150:complications / Q000188:drug therapy; D014268:Trifluoperazine / Q000009:adverse effects* / Q000627:therapeutic use
D014268:Trifluoperazine