[Dynamics of peroxidation of brain tissue lipids in mice infected with influenza virus in the presence of immobilization stress].
The poststress activation of peroxide oxidation reaction (POL) of lipids from brain tissue of the mice CBA and FI (CBA X C57 Black) has been confirmed. The principal difference in the nature of malonic dialdehyde level dynamics in brain tissue determined by a form of infectious process induced by influenza strain A/PR/8/34 pathogenic for mice has been found. The sublethal dose has been shown to activate while the lethal dose to suppress the POL process. Progression of influenza infection at the stress background was accompanied by a sharp unidirectional increase in MDA content in mice brain tissue. The increase was mostly expressed in case of mice infection with a lethal dose of the virus. The data obtained suggest a membrane mechanism for barrier damage as a reason of severing influenza infection by the stress background.
Misheneva
M S
MS
Chetverikova
L K
LK
Frolov
B A
BA
D000818:Animals; D001921:Brain / Q000378:metabolism*; D007103:Immobilization; D008054:Lipid Peroxides / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000150:complications / Q000378:metabolism*; D010084:Oxidation-Reduction; D013312:Stress, Physiological / Q000150:complications / Q000378:metabolism*
D008054:Lipid Peroxides; D008315:Malondialdehyde
Dinamika perekisnogo okisleniia lipidov mozgovoĭ tkani mysheĭ, zarazhennykh virusom grippa na fone immobilizatsionnogo stressa.