Autoradiographic localization of substance P receptors in rat spinal cord: effects of experimental spinal transection.
The autoradiographic localization of Substance P (SP) receptors was studied in the rat spinal cord following thoracic cordotomy. The binding of [125I]-BH-SP was measured in discrete gray matter structures above and below the injury site. There was a significant increase in SP receptor density 1 week after cordotomy in the dorsal horn and in the central canal of lumbar region, and in laminae 3-4-5 and also in the ventral horn of cervical spinal cord. Elevated SP receptor density was noted only in cervical ventral horn at 3 weeks after cordotomy. Since SP concentration has been reported to show similar localized increases, the present results are consistent with an up-regulation of SP receptors.
Vita
G
G
Institute of Neurological and Neurosurgical Sciences, University of Messina, Italy.
Haun
C K
CK
Hawkins
E F
EF
Engel
W K
WK
D000818:Animals; D001345:Autoradiography; D003714:Denervation; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*; D014018:Tissue Distribution
D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter