The role of eicosanoids in paediatrics.
Prostanoids are unsaturated cyclic fatty acids, are synthesized primarily from arachidonic acid, and, like the leukotrienes, belong to the growing family of eicosanoids. As tissue hormones, prostanoids act on specific receptors near their site of synthesis and degradation. Prostanoids operate as modulators and mediators in a large spectrum of physiological processes. They are involved in the regulation of maternal and fetal circulation, patency of the ductus arteriosus, platelet-vessel wall interaction and kidney function. Besides their physiological function in protecting organ perfusion under stress conditions, they are also involved in diseases as described in the hyperprostaglandin E2-syndrome or--together with leukotrienes--in inflammatory processes. More specific pharmacological tools than the nonsteroidal antiinflammatory drugs, such as receptor antagonists, selective synthesis inhibitors, and eicosanoid analogues offer the prospect of enriching our arsenal of pharmacotherapeutic interventions in a variety of diseases. Before active intervention, however, more and specific biochemical analyses are required to identify the pathophysiological role of eicosanoid.
Seyberth
H W
HW
Universitäts-Kinderklinik, Heidelberg, Federal Republic of Germany.
Kühl
P G
PG
D001775:Blood Circulation; D001777:Blood Coagulation; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy; D004537:Eicosanoic Acids / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D005333:Fetus; D006801:Humans; D007668:Kidney / Q000502:physiology; D007975:Leukotriene B4 / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology; D013189:SRS-A / Q000502:physiology
D004537:Eicosanoic Acids; D011453:Prostaglandins; D013189:SRS-A; D007975:Leukotriene B4