title: In vitro activity of LY146032 alone and in combination with other antibiotics against gram-positive bacteria.
abstract: The antibacterial activity of LY146032 alone and in combination with other drugs was assayed against gram-positive isolates. Synergism was found when LY146032 was combined with netilmicin, amikacin, imipenem, and fosfomycin by both checkerboard and time-kill tests. Indifference predominated when LY146032 was combined with teicoplanin, vancomycin, and rifampin. Under no circumstances and with no combinations was an antagonistic effect detected.
authors.affiliation: Institute of Microbiology, Medical School, University of Genoa, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Debbia
authors.forename: A
authors.initials: A
authors.lastname: Pesce
authors.forename: G C
authors.initials: GC
authors.lastname: Schito
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017576:Daptomycin; D004347:Drug Interactions; D004357:Drug Synergism; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; D017576:Daptomycin