title: Effect of implantation site on phagocyte/polymer interaction and fibrous capsule formation.
abstract: Implants of Silastic, Estane, polypropylene oxide and an HPOE/PBT segmented polyether polyester copolymer were qualitatively and quantitatively evaluated, with respect to interaction with mononuclear and multinucleated phagocytes as well as fibrous capsule formation, after implantation at three sites in the rat middle ear. The volume of the phagocyte exudate surrounding the implants, the degree of implant degradation and fragmentation and the thickness of the fibrous capsules were found to be correlated with the implantation site. From these findings, it can be concluded that it is important to assess the biological performance of a biomaterial at carefully chosen implantation sites.
authors.affiliation: Ear, Nose and Throat Department, University of Leiden, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Bakker
authors.forename: C A
authors.initials: CA
authors.lastname: van Blitterswijk
authors.forename: S C
authors.initials: SC
authors.lastname: Hesseling
authors.forename: J J
authors.initials: JJ
authors.lastname: Grote
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D001842:Bone and Bones / Q000166:cytology; D005549:Foreign-Body Reaction; D008297:Male; D008854:Microscopy, Electron; D009092:Mucous Membrane / Q000166:cytology; D009132:Muscles / Q000166:cytology; D009998:Ossicular Prosthesis; D010586:Phagocytes / Q000502:physiology* / Q000648:ultrastructure; D010587:Phagocytosis; D011095:Polyethylenes; D011108:Polymers; D011140:Polyurethanes; D011409:Propylene Glycols; D051381:Rats; D011919:Rats, Inbred Strains; D012826:Silicone Elastomers; D012828:Silicones; D014432:Tympanic Membrane / Q000166:cytology
chemical_list: D001672:Biocompatible Materials; D011095:Polyethylenes; D011108:Polymers; D011140:Polyurethanes; D011409:Propylene Glycols; D012826:Silicone Elastomers; D012828:Silicones; C009879:estane plastic; C012504:polypropylene glycol