The natural history of acquired cytomegalovirus infection among children in group day care.
We studied the natural history of cytomegalovirus (CMV) excretion among 79 children in a single day-care center over a 2 1/2-year period. During the study interval, 28 children (35%) excreted CMV in their urine, or saliva, or both. The CMV acquisition rate among children who were initially culture negative was 12.6% per year. In such children, CMV excretion began 11 to 59 months after entry into day care. The duration of CMV excretion varied from 3.0 to 28.4 months, with a mean of 13.0 +/- 9.1 months for urine and 7.0 +/- 2.7 months for saliva. The quantity of CMV in saliva or urine was highest during the first three months of excretion, as high as 10(5) 50% tissue culture infectious dose per milliliter. Children excreting CMV entered day care at a younger age (mean, 5.3 +/- 8.5 months for excretors vs 12.7 +/- 14.8 months for nonexcretors) and spent more hours in day care per week than the nonexcretors (mean, 41.8 +/- 9.0 h/wk for excretors vs 36.1 +/- 10.9 h/wk for nonexcretors).
Murph
J R
JR
Divisions of Ambulatory Pediatrics, University of Iowa College of Medicine, Iowa City.
Bale
J F
JF
D002648:Child; D002656:Child Day Care Centers; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D007484:Iowa; D008137:Longitudinal Studies; D008297:Male; D012463:Saliva / Q000382:microbiology; D013997:Time Factors; D014505:Urban Population; D014556:Urine / Q000382:microbiology