Chronic administration of sertraline, a selective serotonin uptake inhibitor, decreased the density of beta-adrenergic receptors in rat frontoparietal cortex.
Sertraline, a potent and selective inhibitor of serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]dihydroalprenolol ([3H]DHA) was reduced in cortex layers IV-VI. Results of a saturation experiment indicated that the reduction in cortex layer IV was due to a change in number but not affinity of beta-adrenergic receptors.
Byerley
W F
WF
Department of Psychiatry, University of Utah Medical Center, Salt Lake City 84132.
McConnell
E J
EJ
McCabe
R T
RT
Dawson
T M
TM
Grosser
B I
BI
Wamsley
J K
JK
D015057:1-Naphthylamine / Q000008:administration & dosage* / Q000031:analogs & derivatives; D000818:Animals; D001345:Autoradiography; D004082:Dihydroalprenolol / Q000378:metabolism; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage*; D010296:Parietal Lobe / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D020280:Sertraline
D009281:Naphthalenes; D011943:Receptors, Adrenergic, beta; D012701:Serotonin; D004082:Dihydroalprenolol; D015057:1-Naphthylamine; D020280:Sertraline