[Effect of magnesium ions on the inhibition of the mitochondrial ATPase (ATP-synthetase) complex by azide].
The effect of azide on the activity and phosphorylation of ATPase in rat liver mitochondria was studied. It was shown that in the absence of exogenous Mg2+ azide inhibits both the activity and phosphorylation of ATPase. In the presence of exogenous Mg2+ azide inhibits ATPase hydrolysis, but does not inhibit the enzyme phosphorylation. It is concluded that the one-sided effect of azide on the activity of the ATPase (ATP-synthetase) mitochondrial complex is realized by participation of Mg2+. It was found also that the inhibitory effect of azide depends on the exogenous Mg2+ concentration.
Chakyrov
S
S
Grancharova
E
E
Minkov
I
I
D025181:ATP Synthetase Complexes; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D001386:Azides / Q000494:pharmacology*; D006868:Hydrolysis; D066298:In Vitro Techniques; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000201:enzymology*; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors; D010766:Phosphorylation; D010770:Phosphotransferases / Q000037:antagonists & inhibitors; D051381:Rats
D001386:Azides; D009097:Multienzyme Complexes; D000255:Adenosine Triphosphate; D010770:Phosphotransferases; D025181:ATP Synthetase Complexes; D000251:Adenosine Triphosphatases; D008274:Magnesium
Vliianie ionov magniia na ingibirovanie aktivnosti ATPaznogo (ATP-sintetaznogo) kompleksa mitokhondriĭ azidom.