Tacaribe virus infection may induce inhibition of the activity of the host cell Ca2+ and Na+/K+ pumps.
Infection of Vero cells with Tacaribe virus stocks containing a high ratio of standard (plaque-forming) viruses to defective interfering particles (DIP) induced inhibition of the host cell Ca2+ ATPase (Ca2+ pump) and the ouabain-sensitive Na+/K+ ATPase (Na+/K+ pump). The Mg2+ ATPase which is not involved in cation transport was not affected. The presence of DIP in the inocula protected the cells from alteration of the transport-associated ATPases induced by standard viruses.
Rey
O
O
Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina.
Rossi
J P
JP
López
R
R
Iapalucci-Espinoza
S J
SJ
Franze-Fernández
M T
MT
D000818:Animals; D001116:Arenaviridae / Q000502:physiology*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D003673:Defective Viruses / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D014709:Vero Cells; D014779:Virus Replication
D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase