title: Immunocytological demonstration of HSV-II antigen on exfoliated cells from precancerous and cancerous lesions of the uterine cervix.
abstract: Cancer of the uterine cervix is the most common malignancy among Indian women. Evidence has shown that cervical cancer is preceded by dysplastic, or precancerous, lesions. HSV-II has been associated with this process of cervical carcinogenesis. We collected 167 cervical smears that had been diagnosed as normal, dysplastic, or carcinoma-in-situ and found a significantly high positivity of HSV-II antigen in women with cervical dysplasia (38.8%) and carcinoma-in-situ (33.3%) versus women with normal cytology (17.02%). Latent HSV-II infection of cervical epithelium may be considered of prognostic value to identify a population at high risk for cervical cancer.
authors.affiliation: Division of Immunology and Immunocytology, Maulana Azad Medical College Campus, New Delhi, India.
authors.forename: M M
authors.initials: MM
authors.lastname: Gupta
authors.forename: B K
authors.initials: BK
authors.lastname: Sharma
authors.forename: V
authors.initials: V
authors.lastname: Singh
authors.forename: U K
authors.initials: UK
authors.lastname: Luthra
mesh_terms: D000956:Antigens, Viral / Q000032:analysis*; D002278:Carcinoma in Situ / Q000382:microbiology*; D003593:Cytoplasm / Q000382:microbiology; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D018139:Simplexvirus / Q000276:immunology*; D002578:Uterine Cervical Dysplasia / Q000382:microbiology*; D002583:Uterine Cervical Neoplasms / Q000382:microbiology*; D014626:Vaginal Smears
chemical_list: D000956:Antigens, Viral