title: Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.
abstract: Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.
authors.affiliation: Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY.
authors.forename: R
authors.initials: R
authors.lastname: Sircar
authors.forename: H
authors.initials: H
authors.lastname: Samaan
authors.forename: R
authors.initials: R
authors.lastname: Nichtenhauser
authors.forename: L D
authors.initials: LD
authors.lastname: Snell
authors.forename: K M
authors.initials: KM
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: Rivier
authors.forename: W
authors.initials: W
authors.lastname: Vale
authors.forename: R S
authors.initials: RS
authors.lastname: Zukin
authors.forename: S R
authors.initials: SR
authors.lastname: Zukin
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D001921:Brain / Q000502:physiology*; D008297:Male; D016202:N-Methylaspartate; D009638:Norepinephrine / Q000378:metabolism; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D017478:Receptors, Phencyclidine; D017480:Receptors, sigma
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D011957:Receptors, Opioid; D017478:Receptors, Phencyclidine; D017480:Receptors, sigma; D001224:Aspartic Acid; D016202:N-Methylaspartate; D000109:Acetylcholine; D009638:Norepinephrine