The effect of n-3 fatty acids on lipids and haemostasis in patients with type IIa and type IV hyperlipidaemia.
Plasma lipids and haemostasis were investigated in 17 patients with hyperlipidaemia before and after 6 weeks supplementation with 6 g n-3 fatty acids. Nine of the patients had type IIa and 8 had type IV hyperlipidaemia. No effect on plasma cholesterol, LDL- or HDL-cholesterol were seen, but plasma triglycerides decreased after n-3 supplementation. Apolipoprotein B increased and apolipoprotein A1 decreased after the oil supplement. The bleeding time was prolonged, but platelet aggregation was unaltered by n-3 fatty acids. Protein C activity increased in type IIa and decreased in type IV after the supplement. Fibrinolysis was markedly depressed while von Willebrand factor antigen was reduced after intake of n-3 fatty acids.
Schmidt
E B
EB
Department of Clinical Chemistry, Aalborg Hospital, Denmark.
Ernst
E
E
Varming
K
K
Pedersen
J O
JO
Dyerberg
J
J
D000328:Adult; D004042:Dietary Fats, Unsaturated / Q000009:adverse effects / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000178:diet therapy; D006953:Hyperlipoproteinemia Type IV / Q000097:blood* / Q000178:diet therapy; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged
D004042:Dietary Fats, Unsaturated; D005231:Fatty Acids, Unsaturated; D008055:Lipids