Psychiatric disorders in the first-degree relatives of probands with bulimia nervosa.
Data from a family study of psychiatric disorders showed higher rates of major affective disorders, eating disorders, and alcoholism in first-degree relatives of 40 bulimic probands than in first-degree relatives of 24 control subjects. More importantly, the data showed higher rates of major affective disorders in relatives of bulimic probands who themselves had no history of major affective disorders than in relatives of control subjects. This significant finding indicates a familial relationship between bulimia nervosa and major affective disorders, which suggests the possibility of a common diathesis.
Kassett
J A
JA
Laboratory of Clinical Science, NIMH, Bethesda, MD.
Gershon
E S
ES
Maxwell
M E
ME
Guroff
J J
JJ
Kazuba
D M
DM
Smith
A L
AL
Brandt
H A
HA
Jimerson
D C
DC
D000328:Adult; D000437:Alcoholism / Q000235:genetics; D000987:Antisocial Personality Disorder / Q000235:genetics; D002032:Bulimia / Q000150:complications / Q000235:genetics*; D001068:Feeding and Eating Disorders / Q000235:genetics; D005260:Female; D006801:Humans; D001523:Mental Disorders / Q000150:complications / Q000235:genetics*; D019964:Mood Disorders / Q000235:genetics; D019966:Substance-Related Disorders / Q000235:genetics