title: Interruption of growth signal transduction by an antiviral and antitumoral xanthate compound.
abstract: The binding of growth factors to the cellular receptors elicits the phosphorylation of proteins which transmit growth signals to the nucleus [E. Rozengurt (1986) Science 234, 161-166]. Both the tyrosine-specific kinase (growth factor receptor) and the threonine-serine phosphorylating protein kinase C (pkC) become activated upon binding of the epidermal growth factor (EGF) to its receptor. Here we describe the selective inhibition of the pkC activation by tricyclodecane-9-yl-xanthogenate (D609) in the presence of unsuppressed receptor tyrosine autophosphorylation. As a consequence the affinity of EGF to the receptor was not down-regulated and the complex failed to be internalized.
authors.affiliation: Institute for Virus Research, German Cancer Research Center, Heidelberg.
authors.forename: K
authors.initials: K
authors.lastname: Müller-Decker
authors.forename: C
authors.initials: C
authors.lastname: Doppler
authors.forename: E
authors.initials: E
authors.lastname: Amtmann
authors.forename: G
authors.initials: G
authors.lastname: Sauer
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D002478:Cells, Cultured; D066246:ErbB Receptors / Q000032:analysis; D005347:Fibroblasts / Q000201:enzymology; D009636:Norbornanes; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D013859:Thiocarbamates; D013871:Thiones / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D001952:Bridged-Ring Compounds; D009636:Norbornanes; D013859:Thiocarbamates; D013871:Thiones; C046498:tricyclodecane-9-yl-xanthogenate; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases; D011493:Protein Kinase C