Radioiododemercuration: a simple synthesis of 5-[123/125/127I]iodo-2'-deoxyuridine.
Through the use of iododemercuration, 5-[123/125I]iodo-2'-deoxyuridine was synthesized rapidly and with high radiochemical purity from 5-chloromercuri-2'-deoxyuridine. The synthesis of radioiodinated 2'-deoxyuridine was achieved in one step in the presence of Iodogen in 50% yield after isolation by reverse phase high performance column chromatography. The radiochemical purity was greater than 99%. The ease and the absence of any starting material, suggests that radiohalodemercuration may be the method of choice for this and structurally similar compounds.
Baranowska-Kortylewicz
J
J
Department of Radiology (Nuclear Medicine), Harvard Medical School, Boston, MA 02115.
Kinsey
B M
BM
Layne
W W
WW
Kassis
A I
AI
D007065:Idoxuridine / Q000138:chemical synthesis*; D007457:Iodine Radioisotopes; D008722:Methods
D007457:Iodine Radioisotopes; D007065:Idoxuridine