Combined vaccine against measles, mumps, rubella, and varicella.
A combined measles, mumps, rubella, and varicella vaccine produced seroconversions for all four components similar to that found if measles, mumps, and rubella vaccine or live varicella vaccine were given separately. In addition, those exposed to varicella were completely protected or had only a mild rash. Moreover, the reaction rates were not increased if the vaccines were combined. The somewhat lower and delayed serologic response to live varicella vaccine as compared with the combined measles, mumps, rubella, and varicella may have been due to the small amount of varicella vaccine virus used or to its degree of attenuation. Persistence of antibody was observed 1 year postimmunization.
Brunell
P A
PA
Department of Pediatrics, University of Texas Health Science Center, San Antonio.
Novelli
V M
VM
Lipton
S V
SV
Pollock
B
B
D000914:Antibodies, Viral / Q000096:biosynthesis; D019433:Chickenpox Vaccine; D003872:Dermatitis / Q000209:etiology; D004338:Drug Combinations / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D005334:Fever / Q000209:etiology; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D007223:Infant; D008458:Measles Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D011897:Random Allocation; D012411:Rubella Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D017778:Vaccines, Combined; D014765:Viral Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology
D000914:Antibodies, Viral; D019433:Chickenpox Vaccine; D004338:Drug Combinations; D008458:Measles Vaccine; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine; D012411:Rubella Vaccine; D017778:Vaccines, Combined; D014765:Viral Vaccines; C050102:measles, mumps, rubella, varicella vaccine