Synthesis and binding study on pyrazolo[4,5-c] [1,8]naphthyridines.
Following our previous reports on pyrazolo[4,5-c]quinoline derivatives some isosteric pyrazolo[4,5-c] [1,8]naphthyridines were synthesized and tested for their ability to displace [3H]flunitrazepam from rat brain membranes. The lack of activity of the synthesized compounds and structure-activity relationships for the whole series are discussed.
Cecchi
L
L
Dipartimento di Scienze Farmaceutiche, Università di Firenze, Italy.
Colotta
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V
Filacchioni
G
G
Melani
F
F
Palazzino
G
G
Galli
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A
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D002540:Cerebral Cortex / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D003975:Diazepam / Q000378:metabolism; D005445:Flunitrazepam / Q000378:metabolism; D066298:In Vitro Techniques; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects*; D013570:Synaptic Membranes / Q000378:metabolism
D009287:Naphthyridines; D011720:Pyrazoles; D011963:Receptors, GABA-A; D005445:Flunitrazepam; D003975:Diazepam