title: [Signs of natural infection with hepatitis A in brown macaques (Macaca arctoides)].
abstract: The results of examinations of stump-tailed monkeys (M. arctoides) held in captivity are presented. The presence and levels of anti-HAV and anti-HAV class M in the blood sera of monkeys were determined by the enzyme-immunoassay (EIA), and alanine aminotransferase (AIAT) activity was measured. HAV in stool specimens collected from the monkeys was detected by immune electron microscopy and EIA. In the first examination, 2 out of 10 monkeys were found to have anti-HAV and one of them to have anti-HAV class M. In repeat examination of 4 monkeys 32 days later, two of them showed an increase in AIAT and 3 had HAV in stools. In the 3rd examination in 91 days, all the four animals had anti-HAV and anti-HAV class M. Besides, three seronegative monkeys out of the ten examined initially, showed only total anti-HAV in 91 days. At the time of the 3rd blood specimen collection, 16 more monkeys were examined and all of these had anti-HAV but not anti-HAV class M. It is assumed that natural infection of stumptailed monkeys in captivity with a virus antigenically identical to HAV is possible.
authors.forename: A G
authors.initials: AG
authors.lastname: Andzhaparidze
authors.forename: Z V
authors.initials: ZV
authors.lastname: Shevtsov
authors.forename: L I
authors.initials: LI
authors.lastname: Korzaia
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Karetnyĭ
authors.forename: M S
authors.initials: MS
authors.lastname: Balaian
mesh_terms: D000818:Animals; D000835:Animals, Wild; D005243:Feces / Q000032:analysis / Q000382:microbiology; D006506:Hepatitis A / Q000175:diagnosis / Q000382:microbiology / Q000662:veterinary*; D006508:Hepatitis Antibodies / Q000032:analysis; D006507:Hepatovirus / Q000276:immunology / Q000302:isolation & purification; D007075:Immunoglobulin M / Q000032:analysis; D008251:Macaca; D008992:Monkey Diseases / Q000175:diagnosis* / Q000382:microbiology; D013997:Time Factors
chemical_list: D006508:Hepatitis Antibodies; D007075:Immunoglobulin M
vernacular_title: Priznaki estestvennoĭ infektsii gepatita A u burykh makak.