Paracetamol suppositories: a comparative study.
Paracetamol suppositories in two different bases were given to children who had fever after operations. Plasma concentrations and the effect on temperature were compared. There was a significant correlation between peak plasma concentrations and maximum drop in temperature. A lipophilic base produced better results than a hydrophilic base.
Cullen
S
S
Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin.
Kenny
D
D
Ward
O C
OC
Sabra
K
K
D000082:Acetaminophen / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D011183:Postoperative Complications / Q000188:drug therapy*; D013488:Suppositories
D013488:Suppositories; D000082:Acetaminophen