Demography predicts blood pressure response to once-daily enalapril monotherapy of mild to moderate essential hypertensive patients.
Enalapril was given once daily in low dose (5 to 10 mg) and high dose (20 to 40 mg) in 25 (15 white and 10 black) mild-to-moderate essential hypertensive patients. The white patients had a significant (p less than 0.005) supine diastolic blood pressure (SDBP) lowering with all doses of enalapril (from 97.2 +/- 1.8 to 85 +/- 2.4 mm Hg lowest). The black patient's SDBP did not decrease significantly (100.8 +/- 2.4 to 96.2 +/- 3.7 mm Hg lowest) with enalapril but addition of hydrochlorothiazide achieved satisfactory SDBP control. It is concluded that hydrochlorothiazide should be added if greater than 10 mg/day of enalapril is needed in white patients and the initial therapy in black patients should be a combination of enalapril and hydrochlorothiazide.
Thind
G S
GS
Department of Medicine, University of Louisville, School of Medicine, KY 40292.
D044383:Black People; D001794:Blood Pressure / Q000187:drug effects*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000008:administration & dosage* / Q000627:therapeutic use; D005544:Forecasting; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D011788:Quality of Life; D044465:White People
D006852:Hydrochlorothiazide; D004656:Enalapril