Dynamic aspects in transient hyperphosphatasaemia of infancy.
A 20-month-old boy with absence epilepsy was found to have a strikingly elevated serum alkaline phosphatase (AP) at start of treatment with valproic acid. The monitoring of this therapy made it possible to follow the elimination of AP which was shown to be a first order kinetic with a half-life of 6.1 days. A concurrent adenovirus infection was diagnosed.
Rasmussen
K T
KT
Department of Paediatrics, Rigshospitalet, University Hospital, Copenhagen, Denmark.
Carstensen
H
H
D000257:Adenoviridae Infections / Q000150:complications / Q000201:enzymology*; D000469:Alkaline Phosphatase / Q000097:blood*; D004827:Epilepsy / Q000150:complications / Q000201:enzymology*; D006207:Half-Life; D006801:Humans; D007223:Infant; D008297:Male; D014635:Valproic Acid / Q000008:administration & dosage
D014635:Valproic Acid; D000469:Alkaline Phosphatase