Inhibition by nedocromil sodium of IgE-mediated activation of human mononuclear phagocytes and platelets in allergy.
The demonstration of a specific receptor for IgE on nonmast cell or basophil leukocytes, such as mononuclear phagocytes, eosinophils, and platelets, suggests that these cells may participate directly in immunological disorders of allergy. Thus, a full understanding of the mode of action of antiallergic or antiasthma drugs must take into account their activity on these nonmast cell leukocytes. Consequently, inhibition by nedocromil sodium of IgE-dependent activation of human alveolar macrophages, blood monocytes and platelets, was investigated. This compound induced an inhibition of the IgE-mediated generation of cytotoxic molecules from monocytes and platelets, together with a concomitant inhibition of their oxidative metabolism, measured by chemiluminescence, and a reduction of the potential ability of alveolar macrophages to synthesize and release mediators, estimated by lysosomal beta-glucuronidase activity. These observations confirm the hypothesis that nedocromil sodium acts on a cell compartment other than the classical mast cell population, in IgE-dependent allergy and, more particularly, in asthma.
Thorel
T
T
Centre d'Immunologie et de Biologie Parasitaire, Unité mixte INSERM 167-CNRS 624, Institut Pasteur, Lille, France.
Joseph
M
M
Tsicopoulos
A
A
Tonnel
A B
AB
Capron
A
A
D000402:Airway Obstruction / Q000276:immunology / Q000473:pathology; D001249:Asthma / Q000276:immunology* / Q000473:pathology; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D002470:Cell Survival; D006801:Humans; D007073:Immunoglobulin E / Q000494:pharmacology*; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D017835:Nedocromil; D010586:Phagocytes / Q000187:drug effects / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000166:cytology; D011804:Quinolines / Q000494:pharmacology*
D011804:Quinolines; D017835:Nedocromil; D007073:Immunoglobulin E