Immunohistochemical identification of type I procollagen in tumour cells of scirrhous adenocarcinoma of the stomach.
Human gastric carcinomas were tested for their immunohistochemical reactivity with anti-type I procollagen antiserum. In all specimens of scirrhous carcinomas, staining of the tumour cells was strongly positive, while in medullary carcinomas staining of the tumour cells was generally poor. These results suggest that the tumour cells in scirrhous carcinomas produce collagen in their stroma.
Niitsu
Y
Y
Department of Internal Medicine, Sapporo Medical College, Japan.
Ito
N
N
Kohda
K
K
Owada
M
M
Morita
K
K
Sato
S
S
Watanabe
N
N
Kohgo
Y
Y
Urushizaki
I
I
D002293:Adenocarcinoma, Scirrhous / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D011347:Procollagen / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism*
D011347:Procollagen