title: Polymorphonuclear leucocyte function and previous yersinia arthritis: correlation of enhanced superoxide production with late manifestations.
abstract: Polymorphonuclear leucocyte (PMN) functions (migration in vitro, chemiluminescence, O-2 production, and aggregation) were studied in 32 patients with previous yersinia arthritis (YA). PMNs of 11 HLA-B27 positive patients who had chronic or recurrent inflammatory symptoms showed O-2 production significantly higher than that of PMNs of 11 HLA-B27 positive patients without late manifestations. Also, PMNs of both HLA-B27 positive and negative patients tended to show chemotactic and chemokinetic migration rates higher than those of control cells of healthy HLA-B27 negative subjects. These functional aberrations may play a part in the development of the patients' inflammatory symptoms.
authors.affiliation: Department of Bacteriology and Immunology, University of Helsinki, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Repo
authors.forename: P
authors.initials: P
authors.lastname: Koivuranta-Vaara
authors.forename: M
authors.initials: M
authors.lastname: Leirisalo-Repo
mesh_terms: D000328:Adult; D001170:Arthritis, Infectious / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D002634:Chemotaxis, Leukocyte; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D013481:Superoxides / Q000378:metabolism*; D015009:Yersinia Infections / Q000150:complications / Q000276:immunology* / Q000378:metabolism
chemical_list: D006680:HLA Antigens; D015796:HLA-B27 Antigen; D013481:Superoxides