Venereal papilloma and papillomavirus in a colobus monkey (Colobus guereza).
A papilloma on the penis of a colobus monkey was found to contain papilloma-virus group specific antigens by immunohistochemical analysis and virus-like particles in the nuclei of epithelial cells by transmission electron microscopy. In low-stringency Southern blot hybridizations, DNA from the lesion annealed with human papillomavirus 11 DNA, but not with the DNAs of 13 other papillomaviruses. Using human papillomavirus 11 DNA as a probe in Southern blot hybridizations, DNA from the penile papilloma was shown to contain a supercoiled DNA approximately 8 kilobases in size. This represents the first demonstration of a papillomavirus-associated venereal lesion in a nonhuman primate.
O'Banion
M K
MK
Department of Microbiology, School of Life Sciences, University of Illinois, Urbana.
Sundberg
J P
JP
Shima
A L
AL
Reichmann
M E
ME
D000818:Animals; D003104:Colobus; D004279:DNA, Viral / Q000302:isolation & purification; D008297:Male; D008992:Monkey Diseases / Q000382:microbiology*; D010212:Papilloma / Q000382:microbiology / Q000662:veterinary*; D027383:Papillomaviridae / Q000302:isolation & purification; D014412:Tumor Virus Infections / Q000382:microbiology / Q000662:veterinary*; D014685:Venereal Tumors, Veterinary / Q000382:microbiology*
D004279:DNA, Viral