Inhibition of growth of the dimorphic fungus Paracoccidioides brasiliensis by ajoene.
Ajoene, a garlic-derived compound that prevents platelet activation, inhibited the growth of Paracoccidioides brasiliensis, a fungal pathogen for humans, by affecting the integrity of the fungal cytoplasmic membrane. This action may be the basis for the study of ajoene as a possible specific antifungal drug.
San-Blas
G
G
Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Carcas, Venezuela.
San-Blas
F
F
Gil
F
F
Mariño
L
L
Apitz-Castro
R
R
D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D004220:Disulfides / Q000494:pharmacology*; D008854:Microscopy, Electron; D003904:Mitosporic Fungi; D010228:Paracoccidioides / Q000187:drug effects / Q000254:growth & development* / Q000648:ultrastructure; D010936:Plant Extracts / Q000494:pharmacology*; D013454:Sulfoxides; D013997:Time Factors
D004220:Disulfides; D010936:Plant Extracts; D013454:Sulfoxides; C048980:ajoene