Failure of intraventricular gammaglobulin and alpha interferon for persistent encephalitis in congenital hypogammaglobulinaemia.
A boy with congenital hypogammaglobulinaemia died at the age of 12 years after a viral meningoencephalitis of two and a half years duration due to an untypable picornavirus. He had received intravenous immunoglobulin every four weeks from the time of the start of immunoglobulin replacement treatment at the age of 3 years. The encephalitis did not respond to high dose intravenous gammaglobulin (2500 g during 22 months). The virus could not be isolated during the administration of intraventricular immunoglobulin (38.15 g) and intraventricular recombinant alpha interferon (121 X 10(6) units), but recurred rapidly each time intraventricular treatment was stopped. Further modes of treatment are still required for prevention and treatment of this disorder.
Roberton
D M
DM
Department of Immunology, Royal Children's Hospital, Melbourne, Victoria, Australia.
Jack
I
I
Joshi
W
W
Law
F
F
Hosking
C S
CS
D000361:Agammaglobulinemia / Q000150:complications* / Q000151:congenital; D002675:Child, Preschool; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D007276:Injections, Intraventricular; D007370:Interferon Type I / Q000627:therapeutic use*; D008297:Male; D008590:Meningoencephalitis / Q000209:etiology / Q000628:therapy*; D010850:Picornaviridae Infections / Q000628:therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use
D007074:Immunoglobulin G; D007370:Interferon Type I; D011994:Recombinant Proteins