Metastatic extramammary Paget's disease: dramatic response to combined modality treatment.
A case of extramammary Paget's disease is reported. The distinguishing features of the case are: (1) localization of the primary lesion to the scrotum, (2) development of metastases in the absence of a recognizable underlying carcinoma, and (3) response of the systemic disease to a combination of radiation therapy and chemotherapy. The histogenesis, clinical behavior, and treatment of extramammary Paget's disease are reviewed.
Balducci
L
L
Department of Hematology/Oncology, University of Mississippi Medical Center, Jackson 39216.
Athar
M
M
Smith
G F
GF
Khansur
T
T
McKenzie
D
D
Crawford
E D
ED
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D010145:Paget Disease, Extramammary / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D011879:Radiotherapy Dosage; D012611:Scrotum / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D013997:Time Factors
D008937:Mitomycins; D016685:Mitomycin; D005472:Fluorouracil