Effects of agonists on the intracellular cyclic AMP concentration in monkey trabecular meshwork cells.
We examined the effects of several neuroendocrine agents on the intracellular cyclic AMP level in cultured monkey trabecular meshwork cells. Among the peptide agonists studied, only the vasoactive intestinal peptide elevated the cyclic AMP level. Alpha-melanocyte stimulating hormone, glucagon, and others showed no stimulation. Prostaglandin E1 and L-isoproterenol also enhanced the intracellular cyclic AMP level. Such effects may implicate physiologic roles of these agonists in the trabecular meshwork.
Koh
S W
SW
Department of Ophthalmology, University of Maryland, Baltimore 21201.
Yue
B Y
BY
D000818:Animals; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology*; D008252:Macaca fascicularis; D009490:Neurosecretory Systems / Q000187:drug effects / Q000502:physiology; D011453:Prostaglandins / Q000494:pharmacology*; D014129:Trabecular Meshwork / Q000187:drug effects / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D011453:Prostaglandins; D014660:Vasoactive Intestinal Peptide; D000242:Cyclic AMP; D007545:Isoproterenol