title: Evaluation of valvular regurgitation by factor analysis of first-pass angiography.
abstract: We have evaluated left ventricular regurgitation by means of factor analysis of 99mTc first-pass radionuclide angiography (FPRNA) and time-activity curve deconvolution. The FPRNA regurgitant fraction (RF) was computed in 26 individuals: 13 patients (eight mitral, three aortic, and two mitral-aortic) and 13 controls. The reference method was contrast ventriculography (CV) performed within 1 hr after FPRNA. In 19 patients, CV was preceded by the determination of cardiac output, using indocyanine green dye (n = 16) or thermodilution technique (n = 3), to determine a catheterization regurgitant fraction (CATH-RF). Lung and left ventricular (LV) time-activity curves were gathered by factor analysis and the FPRNA regurgitant fraction assessed by a lagged normal deconvolution of these curves. In valvular regurgitation, the LV deconvolved curve demonstrates the appearance of a long transit time component that is amenable to quantification. The presence of regurgitation was determined by contrast ventriculography. With a 10% RF as an acceptable upper limit of normal for nonregurgitant patients, FPRNA yielded one false-negative and no false-positive studies (n = 26), while CATH-RF yielded two false-negative and four false-positive determinations (n = 19). The following are results of quantitative determination of RF (mean +/- s.d.): FPRNA 0.39 +/- 0.19 (n = 13 Valvular), 0.01 +/- 0.03 (n = 13 Controls); CATH 0.34 +/- 0.24 (n = 11 Valvular), 0.13 +/- 0.12 (n = eight controls). FPRNA was able to differentiate (p less than 0.001) between control patients (CV grading 0) and mild/moderate regurgitation (CV grading 1+ or 2+) and severe regurgitation (3+ or 4+) (p less than 0.025).
authors.affiliation: Division of Nuclear Medicine, Harbor-UCLA Medical Center, Torrance 90509.
authors.forename: L
authors.initials: L
authors.lastname: Philippe
authors.forename: I
authors.initials: I
authors.lastname: Mena
authors.forename: J
authors.initials: J
authors.lastname: Darcourt
authors.forename: W J
authors.initials: WJ
authors.lastname: French
mesh_terms: D000328:Adult; D000368:Aged; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging*; D005069:Evaluation Studies as Topic; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m
chemical_list: D013670:Sodium Pertechnetate Tc 99m