Changes in serum cholinesterase (EC 3.1.1.8) activity in rats consuming a high-fat diet.
Adult male rats were fed on a control diet containing (g/kg) carbohydrate 600, lipid 35 and protein 190, or on a high-fat diet containing carbohydrate 360, lipid 420 and protein 120. After 30 d, the high-fat diet provoked a decrease in serum cholinesterase (EC 3.1.1.8) activity which was reversed by feeding rats on the control diet. The observed decrease after 90 d on the high-fat diet was not seen if a simultaneous daily intraperitoneal injection of a lipotrophic agent containing (mg/kg) S-adenosyl-L-methionine 3, coenzyme A 0.1, UDP-glucose 30 and CDP-choline 1.5 was given to rats on the high-fat diet. The findings are discussed in relation to the apparent susceptibility of serum cholinesterase to dietary components and its possible role in lipid metabolism.
Osada
J
J
Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Zaragoza, Spain.
Aylagas
H
H
Cao
G
G
Miró-Obradors
M J
MJ
Palacios-Alaiz
E
E
D000818:Animals; D002802:Cholinesterases / Q000097:blood*; D003065:Coenzyme A / Q000494:pharmacology; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology; D004041:Dietary Fats / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012436:S-Adenosylmethionine / Q000494:pharmacology; D014532:Uridine Diphosphate Glucose / Q000494:pharmacology
D004041:Dietary Fats; D003566:Cytidine Diphosphate Choline; D012436:S-Adenosylmethionine; D002802:Cholinesterases; D003065:Coenzyme A; D014532:Uridine Diphosphate Glucose