title: [Nephroblastoma with symptomatic neuronal differentiation].
abstract: We report the anatomoclinical analysis of a child with a renal tumor: the preoperative diagnosis was neuroblastoma, because of elevated dopamine urinary excretion and positive MIBG scintigraphy. The histopathological and immunohistochemical analysis revealed a prominent neural differentiation in a multicystic nephroblastoma. This observation recalls the Masson's proposed neuroectodermal histogenesis of Wilms tumor; however the currently accepted metanephrogenic blastematous origin is not reconsidered. This is the first case of nephroblastoma with a neural differentiation detectable otherwise from by pathological analysis.
authors.affiliation: Laboratoire d'Anatomie Pathologique, CHU, Angers.
authors.forename: J P
authors.initials: JP
authors.lastname: Saint-André
authors.forename: M C
authors.initials: MC
authors.lastname: Chapeau
authors.forename: F
authors.initials: F
authors.lastname: Pein
mesh_terms: D002454:Cell Differentiation; D002675:Child, Preschool; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D009396:Wilms Tumor / Q000473:pathology*
vernacular_title: Néphroblastome avec différentiation neuronale symptomatique.