title: Effect of PK 11195, an antagonist of benzodiazepine receptors, on platelet aggregation in a model of anxiety in the rat.
abstract: 1. Anxiety induced by forced swimming increases maximal intensity (h) of platelet aggregation (PAG) and time to reach it (t). 2. PK 11195 pretreatment (12.5 and 25 mg/kg) reverses anxiety-induced PAG changes. At 6.25 mg/kg it inhibits PAG. 3. Changes induced by anxiety on PAG may be mediated by peripheral-benzodiazepine receptors.
authors.affiliation: Departamento de Farmacologia y Terapéutica, Facultad de Medicina, Sevilla, Spain.
authors.forename: J S
authors.initials: JS
authors.lastname: Serrano
authors.forename: A
authors.initials: A
authors.lastname: Hevia
authors.forename: A
authors.initials: A
authors.lastname: Fernández-Alonso
authors.forename: J R
authors.initials: JR
authors.lastname: Castillo
mesh_terms: D000818:Animals; D001007:Anxiety / Q000097:blood*; D005260:Female; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000378:metabolism*
chemical_list: D007546:Isoquinolines; D011963:Receptors, GABA-A; C037850:PK 11195