title: [Neuronal impulse activity in surviving sections of the guinea pig neocortex during blockade of synaptic transmission by adenosine].
abstract: Background neuronal discharges were recorded extracellularly in guinea pig cerebral cortex slices maintained in vitro. Synaptic disconnection was reached by adding 100 microM of adenosine or 20-75 microM of 5-AMP. It was shown that 30-40% of neurons continued to discharge even under conditions of complete synaptic blockade, although the discharge frequency decreased. These neurons were considered as endogenously active ones. Other cells stopped their activity as soon as adenosine reached the slice, but they began to generate action potentials again after superfusion with normal solution. These cells were synaptically activated and were considered as exogenously active. In particular most cells with initially very regular discharges became silent during blockade and restored their activity after superfusion with normal saline. This fact suggests the existence of reverberating activity in neocortical slices with periods of 30-140 ms.
authors.forename: S V
authors.initials: SV
authors.lastname: Karnup
authors.forename: A V
authors.initials: AV
authors.lastname: Kolomoets
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000241:Adenosine; D000249:Adenosine Monophosphate; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009407:Nerve Block; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D013569:Synapses / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D000249:Adenosine Monophosphate; D000241:Adenosine
vernacular_title: Impul'satsiia neĭronov v perezhivaiushchikh srezakh neokorteksa morskoĭ svinki pri blokade sinapticheskoĭ peredachi adenozinom.