title: Effect of diethylcarbamazine on serum antibodies to feline infectious peritonitis in cats.
abstract: In preceding studies by the author, use of the immunomodulator drug diethylcarbamazine resulted in the detection of antibodies to feline oncornavirus-associated cell membrane antigen in nine feline leukaemia virus infected cats that had previously given negative results to this antibody. In the present report, seven diethylcarbamazine-treated cats developed higher serum antibody titres to feline infectious peritonitis more frequently than did seven untreated controls. Since feline infectious peritonitis is caused by a coronavirus, these results suggest that diethylcarbamazine treatment could be exploited for vaccination and treatment strategies for non-retroviral in addition to retroviral infections.
authors.affiliation: Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115.
authors.forename: L W
authors.initials: LW
authors.lastname: Kitchen
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D002415:Cats; D004049:Diethylcarbamazine / Q000494:pharmacology*; D028301:Feline Panleukopenia Virus / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D010321:Parvoviridae / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D004049:Diethylcarbamazine