Cyclic AMP signal transduction in posttraumatic stress disorder.
Cyclic adenosine 3',5'-monophosphate (cAMP) signal transduction was examined in lymphocytes and platelets obtained from patients with posttraumatic stress disorder. Intact lymphocytes from the posttraumatic patients (N = 10) showed significantly lower basal, isoproterenol-, and forskolin-stimulated cAMP levels than those from 10 healthy control subjects. In platelet membrane preparations, basal, forskolin-, aluminum chloride plus sodium fluoride-, and prostaglandin E1-stimulated adenylate cyclase activity levels were all significantly lower in the posttraumatic group than in the control group. The authors discuss the potential role of their findings as a biological marker for posttraumatic stress disorder.
Lerer
B
B
Jerusalem Mental Health Center-Ezrath Nashim, Israel.
Ebstein
R P
RP
Shestatsky
M
M
Shemesh
Z
Z
Greenberg
D
D
D000262:Adenylyl Cyclases / Q000378:metabolism; D000328:Adult; D000527:Alprostadil / Q000494:pharmacology; D000535:Aluminum / Q000494:pharmacology; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D002712:Chlorides / Q000494:pharmacology; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008214:Lymphocytes / Q000378:metabolism*; D008875:Middle Aged; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D013313:Stress Disorders, Post-Traumatic / Q000097:blood* / Q000378:metabolism
D017607:Aluminum Compounds; D002712:Chlorides; D011943:Receptors, Adrenergic, beta; D005576:Colforsin; D000077410:Aluminum Chloride; D000535:Aluminum; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D000527:Alprostadil; D007545:Isoproterenol