title: Inhibition of cAMP phosphodiesterase by some phototherapeutic agents.
abstract: The behaviour of cyclic-3',5'-AMP phosphodiesterase has been studied in the presence of psoralen, 8-methoxy-psoralen (8-MOP), 4,5',8-trimethylpsoralen (TMP) (usually used in PUVA therapy), 4,6,4'-trimethylangelicin (TMA) and khellin recently proposed for the same therapeutical use. TMP and TMA exhibit a significant inhibitory effect on cyclic AMP phosphodiesterase; a light inhibition is produced by khellin at rather high concentration.
authors.affiliation: Institute of Biological Chemistry, University of Siena, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Bovalini
authors.forename: P
authors.initials: P
authors.lastname: Lusini
authors.forename: S
authors.initials: S
authors.lastname: Simoni
authors.forename: D
authors.initials: D
authors.lastname: Vedaldi
authors.forename: L
authors.initials: L
authors.lastname: Andreassi
authors.forename: F
authors.initials: F
authors.lastname: Dall'Acqua
authors.forename: P
authors.initials: P
authors.lastname: Martelli
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D011564:Furocoumarins / Q000494:pharmacology*; D007666:Khellin / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D011564:Furocoumarins; D007666:Khellin; D015105:3',5'-Cyclic-AMP Phosphodiesterases