Inhibitory effect of myoglobin and hemoglobin on the direct-acting mutagenicity of protein pyrolysate heterocyclic amine derivatives.
We have shown in our earlier reports (Arimoto et al., 1980a, b) that hemin and some other porphyrins can inhibit the mutagenicity in Salmonella of heterocyclic amines derived from cooking of proteins. A direct interaction between hemin and the mutagens was implicated on the basis of the observation that some of the mutagens were inactivated when they had been metabolically converted into direct-acting mutagens before the treatment with hemin. Hemin is a bound constituent of various proteins including hemoglobin and myoglobin, which are abundantly present in the blood and muscles, respectively. An interesting question is whether or not hemoglobin and myoglobin can inhibit the activities of the mutagenic heterocyclic amines.
Arimoto
S
S
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Ohara
Y
Y
Hiramoto
K
K
Hayatsu
H
H
D000588:Amines / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation; D002417:Cattle; D003574:Cytochrome c Group / Q000378:metabolism; D004044:Dietary Proteins / Q000009:adverse effects*; D006420:Hemeproteins / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D006571:Heterocyclic Compounds / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics / Q000633:toxicity*; D006736:Horses; D006358:Hot Temperature; D009152:Mutagenicity Tests; D009153:Mutagens / Q000493:pharmacokinetics; D009211:Myoglobin / Q000378:metabolism; D010084:Oxidation-Reduction
D000588:Amines; D003574:Cytochrome c Group; D004044:Dietary Proteins; D006420:Hemeproteins; D006454:Hemoglobins; D006571:Heterocyclic Compounds; D009153:Mutagens; D009211:Myoglobin