Acceleration of recovery from sciatic nerve damage by the ACTH (4-9) analog Org 2766: different routes of administration.
Functional recovery following a sciatic nerve crush in rats was investigated by measuring the reflex withdrawal of the hindpaw to a hot air stream. The ACTH(4-9) analog Org 2766 accelerated recovery when administered subcutaneously (two-daily injections: 10 micrograms/animal; minipumps: 20-40 micrograms/animal per 24 hr: biodegradable microspheres: 40 micrograms/animal per 24 hr), but oral administration (1.5-20 mg/animal daily, in the drinking water; 1.5-15 mg/animal daily, by gavage) was not effective.
Dekker
A J
AJ
Scientific Development Group, Organon International BV, Oss, The Netherlands.
Princen
M M
MM
De Nijs
H
H
De Leede
L G
LG
Broekkamp
C L
CL
D000284:Administration, Oral; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007279:Injections, Subcutaneous; D009416:Nerve Regeneration / Q000187:drug effects*; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000502:physiology
D010446:Peptide Fragments; C013765:Org 2766; D000324:Adrenocorticotropic Hormone