Specific tissue targeting of polyoma virus oncogenicity in athymic nude mice.
Inbred athymic nu/nu mice (BALB/c and C57BL/6) were injected subcutaneously with polyoma virus A2 strain or with polyoma mutants which are able to infect undifferentiated embryonal carcinoma cells and harbor mutations in their enhancer sequences. Mammary adenocarcinomas were induced exclusively in females in which they represent the majority of the tumors. Both males and females developed sarcomas, mostly osteosarcomas, with a similar low frequency. No other type of neoplasm was observed. Mutations affecting the enhancers do not have any effect on the histotype of the tumors. Multiple copies of intact or defective free viral DNA were detected in all tumors. Such a sex-linked specific tissue targeting suggests a hormonal control of tumor initiation and/or promotion. From a pathological point of view, polyoma-induced adenocarcinomas are very similar to human early breast cancers. Tumor induction in nude mice by polyoma virus therefore represents a unique experimental model which differs from the more extensively used newborn immunocompetent mice.
Berebbi
M
M
J.E. CNRS, Marseille, France.
Dandolo
L
L
Hassoun
J
J
Bernard
A M
AM
Blangy
D
D
D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D008325:Mammary Neoplasms, Experimental / Q000209:etiology* / Q000235:genetics; D051379:Mice; D008819:Mice, Nude; D012516:Osteosarcoma / Q000209:etiology* / Q000235:genetics; D011120:Polyomavirus / Q000472:pathogenicity*; D012513:Sarcoma, Experimental / Q000209:etiology* / Q000235:genetics; D012737:Sex Factors
D000952:Antigens, Polyomavirus Transforming; D004279:DNA, Viral