Hepatotoxic effects elicited by n-hexane or n-heptane.
Hepatotoxic effects of n-hexane and n-heptane administered i.p. (1 ml/kg body wt) were studied in albino rats after 1, 2, 7 and 45 days of treatment. Hepatic protein content decreased with n-heptane and total sulphydryl content showed a significant decrease in the rats exposed to either solvent. A significant increase in lipid peroxidation was observed after 24 h and 48 h exposure to n-hexane or n-heptane. A marked decrease in drug metabolizing activity and an increase in pentabarbitone sleeping time was also observed. Hepatic glucose-6-phosphatase, a microsomal marker enzyme, showed a significant decrease.
Goel
S K
SK
Industrial Toxicology Research Centre, Lucknow, India.
Rao
G S
GS
Pandya
K P
KP
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology*; D005260:Female; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D006536:Heptanes / Q000506:poisoning*; D006586:Hexanes / Q000506:poisoning*; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010424:Pentobarbital / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013347:Subcellular Fractions / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism
D006536:Heptanes; D006586:Hexanes; D008054:Lipid Peroxides; D011506:Proteins; D013438:Sulfhydryl Compounds; C026385:n-hexane; C028618:n-heptane; D006899:Mixed Function Oxygenases; D005952:Glucose-6-Phosphatase; D010424:Pentobarbital