Viral infections in beta-thalassemia/hemoglobin E patients.
One hundred ten patients with beta-thal/Hb E disease and 60 normal controls matched for age and socioeconomic status were followed for 1.5 years. They were examined clinically, and blood and plasma were studied for Coxsackie B viruses and others. The findings suggest that the patients are more susceptible to Coxsackie B virus but not to rubella, herpes simplex, cytomegalovirus, adenovirus, and M. pneumoniae. In contrast to bacterial infections, splenectomized patients did not show evidence of increased viral infections.
Wasi
C
C
Department of Microbiology, Siriraj Hospital, Bangkok, Thailand.
Kuntang
R
R
Louisirirotchanakul
S
S
Siritantikorn
S
S
Fucharoen
S
S
Aswapokee
P
P
Aswapokee
N
N
Hirunraks
A
A
Wasi
P
P
D000914:Antibodies, Viral / Q000032:analysis; D003168:Complement Fixation Tests; D003384:Coxsackievirus Infections / Q000150:complications; D029822:Enterovirus B, Human / Q000276:immunology / Q000302:isolation & purification; D005500:Follow-Up Studies; D006385:Hemagglutination Inhibition Tests; D006446:Hemoglobin E / Q000032:analysis*; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D009500:Neutralization Tests; D013789:Thalassemia / Q000097:blood* / Q000150:complications; D014777:Virus Diseases / Q000150:complications*
D000914:Antibodies, Viral; D006455:Hemoglobins, Abnormal; D006446:Hemoglobin E