Low protein diet modifies acrylamide neurotoxicity.
The present study deals with the role of protein deficiency in the neurobehavioural effects of acrylamide in rat pups exposed during pregnancy and early infancy. The data indicated that acrylamide could be more toxic in protein-deficient hosts as it significantly decreased the dopamine and benzodiazepine receptor binding and delayed the development of reflexes and land marks in these pups.
Khanna
V K
VK
Industrial Toxicology Research Centre, Lucknow, India.
Husain
R
R
Seth
P K
PK
D020106:Acrylamide; D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D005260:Female; D009043:Motor Activity / Q000187:drug effects*; D011247:Pregnancy; D011488:Protein Deficiency / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D011963:Receptors, GABA-A / Q000187:drug effects*
D000178:Acrylamides; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D020106:Acrylamide