title: Mass spectrometry studies of a novel digoxin-like substance (DLIS-2) isolated from human plasma ultrafiltrate.
abstract: Two unique low molecular weight (531) compounds with both digoxin-like immunoreactivity and Na, K-ATPase inhibitory properties have been isolated from human plasma. One of these, digoxin-like substance 2, (DLIS-2), was studied by fast atom bombardment mass spectrometry and collisionally activated dissociation mass spectrometry/mass spectrometry. The fragment patterns were interpreted as being derived from a lysophosphatidyl serine containing a novel 19:4 fatty acid side chain. The molecular formula C25H42O9NP is consistent with these observations.
authors.forename: A
authors.initials: A
authors.lastname: Dasgupta
authors.forename: S
authors.initials: S
authors.lastname: Malik
authors.forename: S
authors.initials: S
authors.lastname: Ahmad
authors.forename: M
authors.initials: M
authors.lastname: Kenny
mesh_terms: D001798:Blood Proteins; D002298:Cardenolides; D004077:Digoxin; D006801:Humans; D013058:Mass Spectrometry; D008970:Molecular Weight; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D014462:Ultrafiltration
chemical_list: D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase