[Almost complete disappearance of metastatic pulmonary tumor and reduction of the main hepatic mass in a case of hepatocellular carcinoma treated with UFT].
A 61-year-old female patient with a low density area indicated by abdominal CT was admitted to hospital. Several circular shadows 5-20-mm in diameter were visible on the chest photos. Primary hepatocellular carcinoma complicated by compensatory cirrhosis accompanying pulmonary metastasis was diagnosed from blood biochemistry tests, a high AFP value (390,000 ng/ml) and angiogram findings. After two months of daily administration of 400 mg of UFT as ftorafur, both reduced AFP (46,000 ng/ml) and a reduction of the primary nidus were observed; after four months, the circular shadows were almost completely eliminated on chest photos. Although UFT administration was discontinued (total FT dose 33.6g) due to jaundice, in the eight months after discontinuation no enlargement of the primary nidus, recurrent shadows on chest photos, or recurrent rise of AFP were observed. This case is considered to suggest the effectiveness of UFT against primary hepatocellular carcinoma with accompanying pulmonary metastasis.
Hayashi
K
K
Maruyama
T
T
Nakatsuru
K
K
Nakamura
H
H
Kitamura
T
T
Shigehira
M
M
Tsuda
K
K
Hidaka
Y
Y
D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D008875:Middle Aged; D005641:Tegafur / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D014498:Uracil / Q000008:administration & dosage
D005641:Tegafur; D014498:Uracil