In vitro antiviral activity of dammar resin triterpenoids.
Nine triterpenes with antiviral activity against Herpes simplex virus types I and II in vitro were isolated from dammar resin. Each compound caused a significant reduction in viral cytopathic effect when Vero cells were exposed continuously to 1-10 micrograms/ml of compound for 48 h after viral challenge. The triterpenes were identified as dammaradienol [1], dammarenediol-II [2], hydroxydammarenone-I [3], ursonic acid [5], hydroxyhopanone [11], dammarenolic acid [15], shoreic acid [16], eichlerianic acid [17], and a novel compound, hydroxyoleanonic lactone [7], on the basis of their chromatographic, spectroscopic, and physical properties.
Poehland
B L
BL
Research and Development Division, Smith, Kline and French Laboratories, Philadelphia, Pennsylvania 19101.
Carté
B K
BK
Francis
T A
TA
Hyland
L J
LJ
Allaudeen
H S
HS
Troupe
N
N
D000998:Antiviral Agents; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000032:analysis*; D012116:Resins, Plant / Q000032:analysis; D018139:Simplexvirus / Q000187:drug effects; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
D000998:Antiviral Agents; D012116:Resins, Plant; D014315:Triterpenes