Age-associated changes in pineal adrenergic receptors and melatonin synthesizing enzymes in the Wistar rat.
The nocturnal stimulation of pineal melatonin synthesis and elevation of serum melatonin is known to be reduced in old age in several species. In Wistar rats the capacity of the beta-adrenoceptor to develop supersensitivity (increase in Bmax) during the light period of the diurnal light/dark cycle is lost during maturation (3-6 months) rather than old age. Further, the present study shows that neither the alpha 1- nor beta-adrenoceptor density of the pineal declines as rats age. Pineal hydroxyindole-O-methyltransferase activity does fall (17-55%) in rats after 18 months of age, but nocturnal pineal arylalkylamine N-acetyltransferase activity is not significantly altered. Thus, from examination of these parameters across the life span of the rat, it seems likely that the reported reduction in serum melatonin in old animals is related to a reduced capacity of the pineal to synthesize melatonin, rather than an altered responsiveness of the gland to neural stimulation.
Dax
E M
EM
National Institute on Aging, Francis Scott Key Medical Center, Baltimore, Maryland.
Sugden
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D000121:Acetylserotonin O-Methyltransferase / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000378:metabolism; D001667:Binding, Competitive; D002940:Circadian Rhythm; D007700:Kinetics; D008297:Male; D008550:Melatonin / Q000096:biosynthesis*; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D010870:Pineal Gland / Q000254:growth & development / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; C029247:3-iodopindolol; D010869:Pindolol; D000121:Acetylserotonin O-Methyltransferase; D001191:Arylamine N-Acetyltransferase; D008550:Melatonin