title: [Establishment of a T lymphoid cell line producing a retrovirus of HTLV-I type, from peripheral blood of a patient with tropical spastic paraparesis].
abstract: HTLV-I, the causative agent of Adult T cell Leukemia, has recently been found to be associated with chronic neuromyelopathies common in tropical areas and in Japan. We report here the establishment of a lymphoid T cell line from peripheral blood lymphocytes of a patient with Tropical Spastic Paraparesis. This cell line produces a retrovirus whose morphologic, antigenic and genetic characteristics show no detectable difference from the leukemogenic prototype of HTLV-I.
authors.affiliation: Institut de Recherches sur les Maladies du Sang, Laboratoire de Virologie des Leucémies, L.O.I.-C.N.R.S., Hôpital Saint-Louis, Paris.
authors.forename: A
authors.initials: A
authors.lastname: Gessain
authors.forename: F
authors.initials: F
authors.lastname: Saal
authors.forename: D
authors.initials: D
authors.lastname: Vilette
authors.forename: J
authors.initials: J
authors.lastname: Lasneret
authors.forename: M L
authors.initials: ML
authors.lastname: Giron
authors.forename: F
authors.initials: F
authors.lastname: Sigaux
authors.forename: O
authors.initials: O
authors.lastname: Gout
authors.forename: R
authors.initials: R
authors.lastname: Emanoil-Ravier
authors.forename: G
authors.initials: G
authors.lastname: de Thé
authors.forename: J
authors.initials: J
authors.lastname: Periés
mesh_terms: D000957:Antigens, Viral, Tumor / Q000032:analysis; D002460:Cell Line; D004279:DNA, Viral / Q000032:analysis; D017977:Deltaretrovirus / Q000235:genetics / Q000254:growth & development* / Q000276:immunology; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D009128:Muscle Spasticity / Q000097:blood; D010243:Paralysis / Q000097:blood*; D013601:T-Lymphocytes / Q000382:microbiology* / Q000473:pathology / Q000648:ultrastructure
chemical_list: D000957:Antigens, Viral, Tumor; D004279:DNA, Viral
vernacular_title: Etablissement d'une lignée lymphoïde T productrice d'un rétrovirus de type HTLV-I à partir du sang périphérique d'un patient atteint de paraparésie spastique tropicale.