[Digitalis receptor].
It has been well established that the Na+,K+-ATPase is the pharmacological receptor of cardiac glycosides. One or several endogenous analogues of these digitalis compounds have been shown to interfere with radioimmunoassays (RIA). Given the low therapeutic range of the steroid cardiotonics, such interference must be taken into consideration. The present review briefly describes the digitalis receptor and discusses monitoring by RIA of patients treated with cardiac glycosides. Finally, the putative origin and chemical nature of this (these) endogenous digoxin-like factor(s) are presented in detail.
Rey
H G
HG
Département de pharmacologie, Centre médical universitaire, Genéve.
Anner
B M
BM
D000328:Adult; D000906:Antibodies / Q000032:analysis; D001798:Blood Proteins; D002298:Cardenolides; D004070:Digitalis; D004071:Digitalis Glycosides / Q000627:therapeutic use; D004077:Digoxin / Q000097:blood / Q000276:immunology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010946:Plants, Medicinal; D010947:Plants, Toxic; D011247:Pregnancy; D011863:Radioimmunoassay; D011955:Receptors, Drug; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism
D000906:Antibodies; D001798:Blood Proteins; D002298:Cardenolides; D004071:Digitalis Glycosides; D011955:Receptors, Drug; D012503:Saponins; C027082:digitalis receptor; C034504:digoxin-like factors; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase
Le récepteur digitalique.