Antitumor property of the active principle of jawaharene.
The active principle of Jawaharene (JF1), a mixture of fatty acids, was studied for antitumor properties against Ehrlich Ascites Carcinoma (EAC) and Sarcoma-180 (S-180). Using a Warburg respirometer, respiratory O2-uptake by EAC and S-180 cells was completely inhibited by JF1 at the dose of 100 micrograms ml-1. The in vitro cytotoxicity assay revealed that 100% of JF1-treated tumor cells were killed within 60 min incubation. In vivo, EAC and S-180 ascites tumor development was completely inhibited by JF1 at the dose of 5 mg mouse-1 day-1 X 8.
Das
A K
AK
Department of Pharmacy, Jadavpur University, Calcutta, India.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000494:pharmacology*; D001201:Ascites; D002470:Cell Survival / Q000187:drug effects; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D019301:Oleic Acid; D009829:Oleic Acids / Q000494:pharmacology; D009930:Organic Chemicals; D010101:Oxygen Consumption / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D009829:Oleic Acids; D009930:Organic Chemicals; C006400:jawaharene; D019301:Oleic Acid