[Oxygen free radicals and bronchial asthma].
Oxygen free radicals are released generally by many cells during phagocytosis and cell activation. In asthmatics, some experimental evidence indicates that oxygen free radicals may be considered to be chemical mediators of anaphylaxis. They are released by macrophages, eosinophils and neutrophils, the cells that are found in bronchoalveolar lavage. They may explain some pathological changes, such as hardening of the airways, bronchial hyper-reactivity and inflammation. Therapeutic implications are discussed.
Godard
P
P
Clinique des Maladies Respiratoires, Hôpital Aiguelongue, CHRU, Montpellier.
Damon
M
M
Cluzel
M
M
Bousquet
J
J
Chanez
P
P
Crastes De Paulet
A
A
Michel
F B
FB
D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D005609:Free Radicals; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism
D005609:Free Radicals; D013481:Superoxides; D010100:Oxygen
Radicaux libres de l'oxygène et asthme bronchique.