[Transmembrane transfer of sodium ions in cell membranes of normal and tumor cells].
Changes of sodium transport in tumor cells and their normal analogs were studied. For the first time we used a direct method of investigation with sodium-selective electrodes which permitted the study of ion transport in dynamics. As a result of investigation of sodium transport on malignant transplanted cultures of fibroblasts (7L strain) and on their normal prototypes--embryonic fibroblasts of hamsters, and also on the cells of Ehrlich ascite tumor--it was shown that when transferred the tumor cells in 15% hypertonic solution significant active transport of ions from the cells into the external medium was recorded. This phenomenon was not found in the normal cells. The experiments showed that in the process of malignancy significant changes began in the cellular membranes connected with the disturbance of activation of some enzymes, particularly Na,K-ATPase.
Mtskhvetadze
A V
AV
Chillingarov
A O
AO
Tushishvili
D I
DI
D000818:Animals; D001693:Biological Transport, Active; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D008297:Male; D051379:Mice; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase
Transmembrannyĭ perenos natriia v kletochnykh membranakh normal'nykh i opukholevykh kletok.