Erythrocyte 2,3-diphosphoglycerate in liver diseases.
The erythrocyte 2,3-diphosphoglycerate (2,3-DPG) was studied in patients with liver diseases, chronic obstructive pulmonary disease, and in normal subjects. The level of 2,3-DPG in liver diseases occurred in the following increasing order: chronic persistent hepatitis, chronic active hepatitis, liver cirrhosis, and cirrhosis with hepatocellular carcinoma. A significant negative correlation between the 2,3-DPG concentration and serum albumin concentration was found in the liver diseases. The 2,3-DPG level was correlated to the serum concentration of total bile acids and to the arterial blood pH. A negative correlation was found between the arterial blood pH and the serum albumin concentration. The level of 2,3-DPG in hepatocellular carcinoma and/or liver cirrhosis was higher than that in more hypoxic chronic obstructive pulmonary disease. And an increased level of 2,3-DPG was also shown in nonhypoxic patients with liver diseases. These results suggest that the level of erythrocyte 2,3-DPG increases according to the severity of the liver disease, and compared to the level in hypoxic chronic obstructive pulmonary disease, the level of erythrocyte 2,3-DPG is higher in both hepatocellular carcinoma and liver cirrhosis.
Nakano
T
T
Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Fujioka
H
H
Tamura
S
S
Amuro
Y
Y
Nabeshima
K
K
Hada
T
T
Higashino
K
K
D019794:2,3-Diphosphoglycerate; D001647:Bile Acids and Salts / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood*; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008107:Liver Diseases / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood*; D008173:Lung Diseases, Obstructive / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism
D001647:Bile Acids and Salts; D004163:Diphosphoglyceric Acids; D012709:Serum Albumin; D019794:2,3-Diphosphoglycerate