Role of cyclic AMP in steroid action in rat intestine.
We have investigated the effect of mineralocorticoids on intestinal fluid and electrogenic glucose-linked Na+ transport across isolated sections of the rat small intestine. A rapid in vitro response is observed that contrast with the delay normally associated with steroid hormone responses. Cyclic AMP is known to affect intestinal glucose, water and Na+ transport and the effects of the steroids may be understood in terms of an inhibitory effect on intestinal cyclic AMP production. An inhibitory effect of the steroids on membrane-bound adenylate cyclase has been demonstrated and dose-response effects suggest the presence of specific membrane-bound glucocorticoid receptors.
Franco
F
F
Department of Zoology, The University, Sheffield, U.K.
Snart
R S
RS
D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport; D003345:Corticosterone / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism
D000450:Aldosterone; D003907:Dexamethasone; D012964:Sodium; D000242:Cyclic AMP; D005947:Glucose; D003345:Corticosterone