Superinfection with porcine cytomegalovirus initiating transplacental infection.
Four sows with circulating antibody were exposed to porcine cytomegalovirus. Virus was detected in 8 of 24 foetuses by immunofluorescence and/or virus isolation from 2 sows with low levels of antibody. In 6 of the infected foetuses, the virus was in capillary endothelium and macrophages of the lung, and was associated with interlobular oedema in 2 of these. Virus was also detected in the nasal mucosa, spleen and brain. The majority of the virus-positive foetuses were grossly normal.
Edington
N
N
Department of Microbiology and Parasitology, Royal Veterinary College, London, Gt. Britain.
Broad
S
S
Wrathall
A E
AE
Done
J T
JT
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000382:microbiology / Q000635:transmission / Q000662:veterinary*; D005260:Female; D005315:Fetal Diseases / Q000382:microbiology / Q000662:veterinary*; D005333:Fetus / Q000382:microbiology; D005455:Fluorescent Antibody Technique; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology / Q000635:transmission*
D000914:Antibodies, Viral