Antagonistic adrenergic-muscarinic regulation of M current in smooth muscle cells.
The beta-adrenergic agonist isoproterenol and analogs of adenosine 3',5'-monophosphate (cAMP) induced a potassium current, M current, in freshly dissociated gastric smooth muscle cells. Muscarinic agonists suppress this current, apparently by acting at a locus downstream from regulation of cAMP levels by adenylate cyclase and phosphodiesterase. Thus, M current can be induced by an agent and regulated in antagonistic fashion by beta-adrenergic and muscarinic systems.
Sims
S M
SM
Department of Physiology, University of Massachusetts Medical School Worcester 01655.
Singer
J J
JJ
Walsh
J V
JV
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002024:Bufo marinus; D000242:Cyclic AMP / Q000502:physiology; D004553:Electric Conductivity; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009116:Muscarine / Q000494:pharmacology; D009130:Muscle, Smooth / Q000502:physiology*; D011188:Potassium / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000502:physiology*; D013270:Stomach / Q000502:physiology
D011943:Receptors, Adrenergic, beta; D011976:Receptors, Muscarinic; D009116:Muscarine; D000242:Cyclic AMP; D007545:Isoproterenol; D000109:Acetylcholine; D011188:Potassium