title: The risk of cytomegalovirus transmission by penetrating keratoplasty.
abstract: To investigate the risk of cytomegalovirus transmission by corneal transplantation, we quantitated anticytomegalovirus IgG levels of donor, preoperative, and postoperative serum samples. Of 118 patients, 79 (67%) were seropositive preoperatively. Twenty-five patients who were seronegative preoperatively received a graft from a positive donor and two (8%) seroconverted. Eleven patients who were seronegative preoperatively received a graft from a negative donor and one (9%) seroconverted. None of the patients who seroconverted had a febrile illness and all three grafts were clear.
authors.affiliation: Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City 52242.
authors.forename: E J
authors.initials: EJ
authors.lastname: Holland
authors.forename: S R
authors.initials: SR
authors.lastname: Bennett
authors.forename: R
authors.initials: R
authors.lastname: Brannian
authors.forename: J C
authors.initials: JC
authors.lastname: Osborne
authors.forename: J A
authors.initials: JA
authors.lastname: Goeken
authors.forename: J H
authors.initials: JH
authors.lastname: Krachmer
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D003315:Cornea / Q000382:microbiology; D016039:Corneal Transplantation; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000635:transmission*; D006801:Humans; D007108:Immune Tolerance; D008875:Middle Aged; D012307:Risk Factors; D012698:Serologic Tests; D014019:Tissue Donors
chemical_list: D000914:Antibodies, Viral