[Effect of intra-arterially injected cisplatinum and lipiodol on the rat liver].
The purpose of this study was to elucidate the availability of cis-platinum powder suspended in lipiodol as a means for the treatment of liver cancer. The effects of cis-platinum powder (1.0 mg), suspended in lipiodol or saline (0.1 ml), as well as that of lipiodol (0.1 ml, 0.3 ml) alone, on the liver, was investigated by intra-arterially administration to 72 normal Wistar rats. It was found that injection of Cis-platinum powder suspended in Lipiodol, is compared to the suspension in saline, resulted in higher concentrations of platinum in the liver Severe histological degenerative and necrotic changes were also found. The liver cells were only moderately affected by lipiodol alone, but large amounts of lipiodol multiple anemic infarctions in the peripheral area 24 hours later. These results suggest that cis-platinum itself affects liver cells only slightly and therefore can be used for the treatment of liver cancer.
Kawakami
A
A
Dept. of Radiology and Pathology, Kinki University School of Medicine.
Ishida
O
O
Suzuki
T
T
D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology*; D007269:Injections, Intra-Arterial; D007459:Iodized Oil / Q000008:administration & dosage*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007459:Iodized Oil; D002945:Cisplatin