title: The effect on newborn chicks of oral inoculation of reovirus isolated from chickens with tenosynovitis.
abstract: Reovirus strain 176, isolated from chickens with tenosynovitis, was highly pathogenic following oral inoculation of 1-day-old specific-pathogen-free chicks. Disseminated lesions including hepatic necrosis, splenic lymphostromal cell hyperplasia, and bursal atrophy occurred on day 3 postinoculation (PI), followed by myocarditis on day 6 PI and by pericarditis and tenosynovitis on day 9 PI. Reovirus was isolated from the liver as early as day 1 PI, whereas significant neutralizing antibody was detected on day 13 PI. Mortality occurred from day 4 to day 7 PI, and the death of birds was associated with the severity of hepatic necrosis. The occurrence of tenosynovitis in virus-inoculated birds was subclinical.
authors.affiliation: Tennessee Department of Agriculture, Ellington Agriculture Center, Nashville 37204.
authors.forename: K N
authors.initials: KN
authors.lastname: Tang
authors.forename: O J
authors.initials: OJ
authors.lastname: Fletcher
authors.forename: P
authors.initials: P
authors.lastname: Villegas
mesh_terms: D000818:Animals; D002060:Bursa of Fabricius / Q000473:pathology; D002645:Chickens; D008099:Liver / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D011201:Poultry Diseases / Q000382:microbiology* / Q000473:pathology; D012087:Reoviridae / Q000472:pathogenicity*; D012088:Reoviridae Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D013047:Specific Pathogen-Free Organisms; D013154:Spleen / Q000473:pathology; D013710:Tendons / Q000473:pathology; D013717:Tenosynovitis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*