title: Ontogeny of cyclic AMP and cyclic GMP phosphodiesterase activities and of calmodulin levels in guinea pig ureter.
abstract: Cyclic AMP and cyclic GMP phosphodiesterase (PDE) activities and calmodulin levels were determined in ureters from guinea pigs of the following ages: 50 and 56 days fetuses, three, 10, 21, 50, and 90 days, and three years old. While there is little change in ureteral cyclic AMP-PDE with age, cyclic GMP-PDE increases with age. Activity of cyclic GMP-PDE in supernatants prepared from three-year-old guinea pig ureter homogenates is 462% and 216% higher than that from 50-day fetus and three-day animals, respectively. Calmodulin levels have a bimodal distribution with age; values are highest in supernatants from 10 and 21 day ureters, but also increase in the three-year ureters when compared to 50 and 90-day values.
authors.affiliation: Section of Urology, Yale University School of Medicine, New Haven, Connecticut 06504.
authors.forename: Y H
authors.initials: YH
authors.lastname: Cho
authors.forename: M A
authors.initials: MA
authors.lastname: Wheeler
authors.forename: R M
authors.initials: RM
authors.lastname: Weiss
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism*; D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000378:metabolism*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D002147:Calmodulin / Q000378:metabolism*; D006168:Guinea Pigs; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000378:metabolism* / Q000502:physiology; D014513:Ureter / Q000378:metabolism* / Q000502:physiology
chemical_list: D002147:Calmodulin; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D015106:3',5'-Cyclic-GMP Phosphodiesterases