title: Internal desynchronization between circadian rhythms of plasma aldosterone and erythrocyte membrane-bound Na/K-ATPase.
abstract: Normal-renin essential mesor hypertensives are characterized by a consistent increase in erythrocyte membrane-bound Na/K-ATPase activity. Low-renin essential hypertensives exhibit, in contrast, a lower activity in Na/K-ATPase of cell membranes. This study documents a third disorder characterized by a temporal shift in the rhythmic activity of the erythrocyte membrane-bound Na/K-ATPase in normal-renin hypertensives. The disorder causes the synchronism with the aldosterone circadian rhythm to be invariably lost. The uncoupling phenomenon could be invoked to explain the inversion in the day-night sodium excretion rate found in essential hypertensives. In addition, it suggests that the circadian rhythm in Na/K-ATPase is under the control of cycling factors other than aldosterone.
authors.forename: P
authors.initials: P
authors.lastname: Cugini
authors.forename: C
authors.initials: C
authors.lastname: Letizia
authors.forename: G
authors.initials: G
authors.lastname: Murano
authors.forename: P
authors.initials: P
authors.lastname: Lucia
authors.forename: D
authors.initials: D
authors.lastname: Scavo
authors.forename: R
authors.initials: R
authors.lastname: Verna
mesh_terms: D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood*; D002940:Circadian Rhythm; D004910:Erythrocyte Membrane / Q000201:enzymology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000201:enzymology; D008297:Male; D012083:Renin / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*
chemical_list: D000450:Aldosterone; D012083:Renin; D000254:Sodium-Potassium-Exchanging ATPase