title: Adverse effect of low-dose prophylactic human recombinant leukocyte interferon-alpha treatment in renal transplant recipients. Cytomegalovirus infection prophylaxis leading to an increased incidence of irreversible rejections.
abstract: Since infections with Herpetoviridae after kidney transplantation still remain a major clinical problem, we conducted a double-blind, placebo-controlled trial using low-dose recombinant interferon-alpha-2C (rIFNa2C) prophylaxis in 50 renal graft recipients immunosuppressed with cyclosporine and methylprednisolone. Ten patients were excluded from further analysis because of graft loss due to surgical complications, side effects of rIFNa2C, and because of lack of compliance. There was a significant difference in graft loss due to irreversible rejections between the verum and the placebo group (6 vs. 0; P less than 0.05), whereas no difference was observed with regard to the occurrence of viral infections. We conclude, that low-dose rIFNa2C prophylaxis is harmful in renal allograft recipients treated with cyclosporine in view of the high incidence of irreversible transplant rejections without beneficial effects on the occurrence of viral infections.
authors.affiliation: Second Department of Internal Medicine, University of Vienna, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Kovarik
authors.forename: G
authors.initials: G
authors.lastname: Mayer
authors.forename: E
authors.initials: E
authors.lastname: Pohanka
authors.forename: M
authors.initials: M
authors.lastname: Schwarz
authors.forename: O
authors.initials: O
authors.lastname: Traindl
authors.forename: H
authors.initials: H
authors.lastname: Graf
authors.forename: J
authors.initials: J
authors.lastname: Smolen
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D003524:Cyclosporins / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000209:etiology; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006084:Graft Rejection / Q000187:drug effects; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D003524:Cyclosporins; D007370:Interferon Type I; D011994:Recombinant Proteins