title: Interferon-alpha in treatment of intraepithelial neoplasia of the lower genital tract: a case report.
abstract: A patient with persistent intraepithelial neoplasia of the vulva, vagina and cervix was treated with subcutaneous injections of interferon-alpha-2b. Previous surgical and laser procedures had failed. HPV subtype 16 was found in biopsies from all sites and an immunological screening was performed before and after therapy. Histologically proven regression of the intraepithelial neoplasia was seen at all sites, with a complete remission of the cervical lesions. The role of interferon in treatment of intraepithelial neoplasia is discussed.
authors.affiliation: Department of Obstetrics and Gynecology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: B J
authors.initials: BJ
authors.lastname: Slotman
authors.forename: T J
authors.initials: TJ
authors.lastname: Helmerhorst
authors.forename: P W
authors.initials: PW
authors.lastname: Wijermans
authors.forename: J J
authors.initials: JJ
authors.lastname: Calame
mesh_terms: D000328:Adult; D005260:Female; D005833:Genital Neoplasms, Female / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D027383:Papillomaviridae; D014412:Tumor Virus Infections / Q000473:pathology / Q000628:therapy*; D002583:Uterine Cervical Neoplasms / Q000382:microbiology / Q000628:therapy; D014625:Vaginal Neoplasms / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D014846:Vulvar Neoplasms / Q000382:microbiology / Q000628:therapy
chemical_list: D007370:Interferon Type I