Long-term effects of the administration of the convulsive substance DL-methionine-DL-sulfoximine to the rabbit.
Methionine sulfoximine (MSO) is a centrally acting neurotoxin which inhibits the glutamate metabolism enzymes and has convulsive properties. Administration of a small dose of MSO to rabbits, either intravenously or intracerebroventricularly, except for the already known convulsive effects, may also be responsible for hind leg myopathy (rigid paralysis with histological findings resembling myositis) which sets in by the 4th day after MSO administration.
Apostolakis
M
M
Department of Physiology, Faculty of Medicine, University of Thessaloniki, Greece.
Anogianakis
G
G
Kallaras
C
C
Zaraboukas
T
T
Liangouris
J
J
Nowack-Apostolaki
E
E
Economou
L
L
D000818:Animals; D002531:Cerebellum / Q000187:drug effects / Q000473:pathology; D003292:Convulsants / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008717:Methionine Sulfoximine / Q000008:administration & dosage / Q000494:pharmacology*; D009132:Muscles / Q000187:drug effects / Q000473:pathology; D011817:Rabbits; D013997:Time Factors
D003292:Convulsants; D008717:Methionine Sulfoximine