[Specific IgM of cytomegaloviruses and primary infection in kidney transplant patients].
In 20 renal transplant recipients suffering from symptomatic CMV infection we looked if a specific IgM response was indicative of a primary infection. By an ELISA technique we investigated the specific IgG and IgM in a pair of sera taken at the time of the transplantation and later at the time of the CMV isolation. For 7 out of 8 patients exhibiting an IgM response in the late serum, the pretransplant serum did not contain either IgG or IgM specific antibodies. Therefore the specific IgM response was associated in 7 out of 8 patients with a primary CMV infection. Nevertheless in 6 other primary infected patients no specific IgM response was detected. Otherwise rheumatoid factors appeared in each primary infected patient developing a specific IgG response, with or without specific IgM response.
Devillechabrolle
A
A
Laboratoire de Bactériologie-Virologie, Group Hospitalier Pitié-Salpêtrière, Paris, France.
Nguyen
T T
TT
Luciani
J
J
Frantz
P
P
Huraux
J M
JM
D000914:Antibodies, Viral / Q000032:analysis; D003586:Cytomegalovirus Infections / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis*; D016030:Kidney Transplantation; D011183:Postoperative Complications
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M
IgM spécifiques du cytomégalovirus et primo-infection chez les transplantés rénaux.