Effect of the composition of the eluent in the chromatography of 99mTc-diphosphonate complexes.
When the ligand and the reducing agent are added to the eluent used in the separation of 99mTc-diphosphonate complexes by column chromatography, a significant increase in recovery is obtained. The addition of the ligand and the reducing agent also influences the shape of the chromatogram.
Huigen
Y M
YM
Analytical Chemistry Laboratory, State University of Utrecht, The Netherlands.
Gelsema
W J
WJ
de Ligny
C L
CL
D002845:Chromatography / Q000379:methods*; D004164:Diphosphonates / Q000302:isolation & purification*; D004355:Drug Stability; D013667:Technetium / Q000302:isolation & purification*; D017556:Technetium Compounds
D004164:Diphosphonates; D017556:Technetium Compounds; D013667:Technetium; C029045:technetium Tc 99m diphosphonate