Synthesis of (+)-1,5-dideoxy-1,5-imino-D-galactitol, a potent alpha-D-galactosidase inhibitor.
Bernotas
R C
RC
Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, New York 14853.
Pezzone
M A
MA
Ganem
B
B
D000818:Animals; D005688:Galactosamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005696:Galactosidases / Q000037:antagonists & inhibitors*; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors; D050112:Imino Pyranoses; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009904:Optical Rotation; D013329:Structure-Activity Relationship; D000519:alpha-Galactosidase / Q000037:antagonists & inhibitors*
D050112:Imino Pyranoses; D007202:Indicators and Reagents; C051196:1,5-dideoxy-1,5-iminogalactitol; D005688:Galactosamine; D005696:Galactosidases; D006026:Glycoside Hydrolases; D000519:alpha-Galactosidase