Blood copper in organophosphate-induced delayed polyneuropathy.
Some organophosphorous esters cause a polyneuropathy which becomes clinically evident 2 weeks after a single dose. The pathogenesis involves modifications of a target protein, neuropathy target esterase, in the axons and a selective inhibition of retrograde axonal transport. It was suggested that copper metabolism might also be involved because of increased levels of plasma copper and ceruloplasmin in animals developing this polyneuropathy. Our results do not confirm this observation; treatment of hens with highly neuropathic single doses of two organophosphates (dihexyl-2,2-dichlorovinyl phosphate and mono-o-cresyl diphenyl phosphate) does not affect total and plasma free copper when measured several times during the development of polyneuropathy. We concluded that copper homeostasis is not affected and that copper changes are unlikely to be involved in the pathogenesis of this polyneuropathy.
Lotti
M
M
Istituto di Medicina del Lavoro, Università degli Studi di Padova, Italy.
Caroldi
S
S
Moretto
A
A
D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000037:antagonists & inhibitors; D002645:Chickens; D003300:Copper / Q000097:blood*; D005260:Female; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000139:chemically induced*
D009943:Organophosphorus Compounds; D003300:Copper; D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase