Cloning, nucleotide sequence and characterization of a New Zealand rabbit metallothionein-I gene.
We have isolated a rabbit metallothionein-I gene from a lambda gt10 library. The coding sequence of this gene is interrupted by two introns occurring at amino acid positions 9 1/3 and 30 1/3. Comparison of the promoter sequence of this gene with the promoters of other metallothionein genes identified a number of oligonucleotide sequences which are recognized by trans-acting proteins involved in the regulation of these genes by heavy metals, glucocorticoids and alpha interferon.
Tam
Y C
YC
Department of Microbiology, Faculty of Medicine Centre Hospitalier Universitaire, Sherbrooke, Quebec, Canada.
Chopra
A
A
Hassan
M
M
Thirion
J P
JP
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes / Q000378:metabolism; D005091:Exons; D007438:Introns; D008668:Metallothionein / Q000235:genetics*; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D011817:Rabbits
D008668:Metallothionein; D004262:DNA Restriction Enzymes