title: Paget's disease with extensive involvement of the female genital tract initially detected by cervical cytosmear.
abstract: A 78-year-old woman with extramammary Paget's disease presented with vaginal bleeding and vulvar pruritus. Paget's cells were demonstrated initially in a cervical cytosmear and, subsequently, in the epithelia of the vagina and cervix, in addition to those of the vulva, periurethral area, and perineum. Such extensive intraepithelial spread of Paget's disease in the genital tract has rarely been reported previously. This is the first case, to our knowledge, in which the cells of cervicovaginal Paget's disease were detected by Papanicolaou smear.
authors.affiliation: Department of Pathology, Beth Israel Hospital, Boston, MA 02215.
authors.forename: T J
authors.initials: TJ
authors.lastname: Costello
authors.forename: H H
authors.initials: HH
authors.lastname: Wang
authors.forename: S J
authors.initials: SJ
authors.lastname: Schnitt
authors.forename: R
authors.initials: R
authors.lastname: Ritter
authors.forename: D A
authors.initials: DA
authors.lastname: Antonioli
mesh_terms: D000368:Aged; D001706:Biopsy; D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology* / Q000601:surgery; D005836:Genitalia, Female / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D010145:Paget Disease, Extramammary / Q000473:pathology* / Q000601:surgery; D065006:Papanicolaou Test; D010502:Perineum / Q000473:pathology; D014521:Urethra / Q000473:pathology; D014626:Vaginal Smears