[Potential value of eicosapentaenoic acid].
The arachidonic acid substitution by an alternative fatty acid, substrate for the 5-lipoxygenase and the cyclo-oxygenase pathway constitutes a novel therapeutic approach or a complement for other therapeutics in the inflammation area. Eicosapentaenoic acid (EPA), one of the fish oil components, is a substrate for both enzymes and an inhibitor for several enzymes of arachidonic acid cascade, in vitro and in vivo. The EPA-generated metabolites have less pro-inflammatory effects than those produced by arachidonic acid metabolism.
Robin
J L
JL
D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000378:metabolism; D015118:Eicosapentaenoic Acid / Q000378:metabolism / Q000627:therapeutic use*; D005395:Fish Oils / Q000008:administration & dosage / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D007975:Leukotriene B4 / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism
D005395:Fish Oils; D007975:Leukotriene B4; D015118:Eicosapentaenoic Acid; D001094:Arachidonate 5-Lipoxygenase
Intérêt potentiel de l'acide eicosapentaénoïque.