Acute and chronic effects of climbing fiber lesions on cerebellar cyclic guanosine monophosphate.
The neurotoxin 3-acetylpyridine was administered to 20-day-old rats to produce lesions of the inferior olive-climbing fiber projection to the cerebellum. Cerebellar cGMP levels were determined 6 h, 24 h, 48 h, 7 days, 14 days and 20 days postlesion. A significant effect on cGMP was found only at 48 h (-28%) and 7 days (-45%) postlesion. The results are discussed with respect to the cellular localization of cGMP and the hypothesized relationship of cGMP to cerebellar Purkinje cell activity.
Oltmans
G A
GA
Department of Pharmacology, University of Health Sciences, Chicago Medical School, IL 60064.
Moss
L E
LE
Lorden
J F
JF
Beales
M
M
D000200:Action Potentials; D000818:Animals; D002531:Cerebellum / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D005260:Female; D008297:Male; D009412:Nerve Fibers / Q000502:physiology*; D009847:Olivary Nucleus / Q000502:physiology*; D011689:Purkinje Cells / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission; D013997:Time Factors
D006152:Cyclic GMP