Plasma retinol, beta-carotene and vitamin E levels in relation to the future risk of pre-eclampsia.
20 healthy primigravidas were studied from 28 weeks' gestation until 4 days after delivery. In 9 of these women pre-eclampsia developed, the remaining 11 subjects who were age-matched had normal pregnancies. Plasma retinol, beta-carotene and vitamin E concentrations were measured by high performance liquid chromatography. The concentrations of retinol and vitamin E were significantly lower in the pre-eclampsia group than in the normotensive group at 28 weeks' gestation--that is before the onset of symptoms and signs of pre-eclampsia. The concentrations of retinol and vitamin E remained significantly lower in the pre-eclampsia group until delivery. It is suggested that measurement of the retinol or vitamin E concentration in plasma may be useful as a predictor of the likely development of pre-eclampsia.
Jendryczko
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Department of Biochemistry and Chemistry, Silesian Medical School, Katowice.
Drozdz
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D002338:Carotenoids / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis; D011237:Predictive Value of Tests; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D014801:Vitamin A / Q000097:blood*; D014810:Vitamin E / Q000097:blood; D014815:Vitamins / Q000097:blood*; D019207:beta Carotene
D014815:Vitamins; D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E; D002338:Carotenoids