title: A route to 2',5'-oligoadenylates with increased stability towards phosphodiesterases.
abstract: The rates of enzymatic hydrolysis of 2',5'-oligoadenylates and their synthetic analogs have been measured. These compounds were treated with either NIH 3T3 cell lysates, mouse liver homogenates or snake venom phosphodiesterase. All analogs with 3'-terminal acyclic nucleoside residues demonstrated greater stability compared with the natural compound adenylyl(2'-5')adenylyl(2'-5')adenosine.
authors.affiliation: Institute of Molecular Biology, USSR Academy of Sciences, Moscow.
authors.forename: A V
authors.initials: AV
authors.lastname: Itkes
authors.lastname: Karpeisky MYa
authors.forename: O N
authors.initials: ON
authors.lastname: Kartasheva
authors.forename: S N
authors.initials: SN
authors.lastname: Mikhailov
authors.forename: G P
authors.initials: GP
authors.lastname: Moiseyev
authors.forename: W
authors.initials: W
authors.lastname: Pfleiderer
authors.forename: R
authors.initials: R
authors.lastname: Charubala
authors.forename: G I
authors.initials: GI
authors.lastname: Yakovlev
mesh_terms: D000227:Adenine Nucleotides / Q000138:chemical synthesis / Q000378:metabolism; D000818:Animals; D002474:Cell-Free System; D066298:In Vitro Techniques; D051379:Mice; D009843:Oligoribonucleotides / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000227:Adenine Nucleotides; D009843:Oligoribonucleotides; C023505:2',5'-oligoadenylate; D010727:Phosphoric Diester Hydrolases