title: Liver adenoma and focal nodular hyperplasia in a man with high endogenous sex steroids.
abstract: The authors report the case of a 29-yr-old man presenting with both hepatocellular adenoma and focal nodular hyperplasia. The patient had never been treated with androgens or estrogens. Investigations revealed the existence of high plasma levels of androgens and estrogens. In addition, the patient presented features compatible with the syndrome of partial androgen resistance. We propose that the hepatic lesions could be secondary to an abnormally high secretion of sex steroids. We suggest that in the absence of known intake of either estrogens or androgens, the existence of hepatocellular adenoma or focal nodular hyperplasia, or both, should indicate a search for abnormal secretion of sex steroids.
authors.affiliation: Clinique d'Hépato-Gastroentérologie, Service d'Anatomie-Pathologie, Hôpital Saint Antoine, Paris, France.
authors.forename: J D
authors.initials: JD
authors.lastname: Grangé
authors.forename: J
authors.initials: J
authors.lastname: Guéchot
authors.forename: C
authors.initials: C
authors.lastname: Legendre
authors.forename: J
authors.initials: J
authors.lastname: Giboudeau
authors.forename: F
authors.initials: F
authors.lastname: Darnis
authors.forename: R
authors.initials: R
authors.lastname: Poupon
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000473:pathology; D006801:Humans; D006965:Hyperplasia / Q000209:etiology; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D013735:Testicular Hormones / Q000378:metabolism*
chemical_list: D013735:Testicular Hormones