title: A double-blind randomised cross-over comparison of nabilone and metoclopramide in the control of radiation-induced nausea.
abstract: Forty patients who were suffering from radiation induced emesis were entered into a prospectively randomised double-blind cross-over study comparing nabilone with metoclopramide. Only patients who had at least five treatments remaining of their planned course of irradiation were randomised, in order to allow an adequate time to monitor the degree of symptom control and any adverse effects of the two drugs. Patient characteristics and the incidence and severity of nausea and vomiting were similar for the two groups. There was no difference in the efficacy of the two drugs but the incidence and severity of adverse reactions was significantly greater in those patients who received nabilone.
authors.affiliation: Department of Radiotherapy, Queen Elizabeth Hospital, Birmingham.
authors.forename: S G
authors.initials: SG
authors.lastname: Priestman
authors.forename: T J
authors.initials: TJ
authors.lastname: Priestman
authors.forename: P A
authors.initials: PA
authors.lastname: Canney
mesh_terms: D000932:Antiemetics / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D013759:Dronabinol / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D009325:Nausea / Q000188:drug therapy* / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D011897:Random Allocation
chemical_list: D000932:Antiemetics; C011941:nabilone; D013759:Dronabinol; D008787:Metoclopramide