Screening of edible plants against possible anti-tumor promoting activity.
One hundred twenty-one species of edible plants (133 test-parts) were screened against possible anti-tumor promoting activity by an in vitro short-term assay system of inhibition of Epstein-Barr virus (EBV) activation induced by a phorbol-ester promoter, 12-O-hexadecanoylphorbol-13-acetate (HPA). The methanol-extracts (ME) of 14 species of the edible plants strongly inhibited the activation, 7 moderately and 12 weakly inhibited it. On partition of the randomly selected inactive ME (26 species) with ethyl acetate and water, 13 and 2 species were active, more or less, in the ethyl acetate and water soluble part, respectively. Thus, this result suggested that anti-tumor promoters occur in a wide variety of edible plants. The anti-tumor promoting activity in the crude extracts may be enhanced or reduced with co-occurring factors acting additively, synergistically or antagonistically.
Koshimizu
K
K
Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan.
Ohigashi
H
H
Tokuda
H
H
Kondo
A
A
Yamaguchi
K
K
D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis*; D004854:Herpesvirus 4, Human / Q000187:drug effects; D006801:Humans; D010703:Phorbol Esters; D010945:Plants, Edible / Q000032:analysis*; D014775:Virus Activation / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D010703:Phorbol Esters