[Possible molecular mechanisms of limited or infinite division of cells].
A new approach to the possible molecular mechanisms which determine the ability of cells to the infinite or limited division is presented. The ideas proposed are based on the experimentally demonstrated premise that the realization of DNA reparation and replication depends on the maintenance of a strict balance between the growth rate of replication forks and SSB-protein synthesis within the cells. The limited ability of cells to the division is considered to be a result of the disorganization of DNA reparation and replication processes when the above-mentioned balance is disturbed. The infinite ability of cells to the division is interpreted as a result of the absence of the disorganization of the above-mentioned processes with disturbance of the same balance. The molecular mechanisms which determine either the presence or absence of the cell response to the disturbed balance between the growth rates of replication forks and SSB-protein synthesis are discussed in detail. The conclusion is drawn that the ssb-gene is a protooncogene converted into an oncogene as a result of the dotted mutation manifesting in the functional inactivation of the third domain of the SSB-proteins.
Fradkin
G E
GE
D001426:Bacterial Proteins / Q000235:genetics; D002455:Cell Division; D004265:DNA Helicases / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics
D001426:Bacterial Proteins; D004265:DNA Helicases
O vozmozhnykh molekuliarnykh mekhanizmakh ogranichennogo ili beskonechnogo deleniia kletok.