Genital warts, papillomaviruses, and genital malignancies.
Human papillomavirus (HPV) infections of the genital tract are widespread and often subclinical. Of about a dozen genital tract HPVs, types 16 and 18 are strongly associated with squamous cell carcinoma of the cervix and of other sites in the lower genital tract. In invasive cervical cancers, the viral genomes are often integrated into the cellular DNA and are transcriptionally active. These viruses, with additional cofactors, play a role in genital tract malignancies.
Shah
K V
KV
Department of Immunology and Infectious Diseases, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205.
Buscema
J
J
D002294:Carcinoma, Squamous Cell / Q000209:etiology; D005260:Female; D005814:Genes, Viral; D005833:Genital Neoplasms, Female / Q000209:etiology*; D005834:Genital Neoplasms, Male / Q000209:etiology*; D006801:Humans; D008297:Male; D027383:Papillomaviridae; D012749:Sexually Transmitted Diseases / Q000209:etiology; D014412:Tumor Virus Infections; D014860:Warts / Q000209:etiology*