The effect of short-term lithium administration on noradrenaline metabolism in the limbic forebrain and hemispheres of rats.
Short-term lithium administration to rats affected the turnover of noradrenaline (NA) in the limbic forebrain and in the hemispheres in different ways. An increase was found in the limbic forebrain whereas no effect was seen in the hemispheres. This finding suggests that short-term lithium administration has regionally variable effects on the turnover of NA in brain. Short-term lithium administration had no significant effect on the endogenous levels or on the synthesis of NA in the two brain parts examined.
Berggren
U
U
Department of Pharmacology, University of Göteborg, Sweden.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002712:Chlorides / Q000008:administration & dosage / Q000494:pharmacology*; D008032:Limbic System / Q000187:drug effects / Q000378:metabolism; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology*; D018021:Lithium Chloride; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride; D009638:Norepinephrine