Short-term estrogen test for cytodiagnosis in postmenopausal women.
A short-term estrogen test was used to obtain a correct cytologic diagnosis in 73 patients with an equivocal atrophic cellular pattern. Overestimation in cytodiagnosis was markedly eliminated, and the correct cytologic diagnosis was made in 81% of the cell samples after the estrogen test. The purpose of this study was not only to confirm the usefulness of the short-term estrogen test, but also to observe the cytomorphologic changes before and after the test. Thick cytoplasm, vacuoles in the cytoplasm, and a distinct cell border increased, while the amorphous chromatin pattern was eliminated after the estrogen test. Maturation of atypical cells in cases of dysplasia, carcinoma in situ, and invasive squamous-cell carcinoma was investigated before and after the estrogen test. Although malignant cells were not influenced by estrogen, maturation of dysplastic cells was induced after the test.
Kashimura
M
M
Department of Obstetrics and Gynecology, University of Occupational and Environmental Health, Fukuoka, Japan.
Baba
S
S
Nakamura
S
S
Matsukuma
K
K
Kamura
T
T
D000328:Adult; D000368:Aged; D003581:Cytodiagnosis / Q000379:methods; D004966:Estrogens, Conjugated (USP); D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D002577:Uterine Cervical Diseases / Q000175:diagnosis* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology; D002575:Uterine Cervicitis / Q000175:diagnosis / Q000473:pathology
D004966:Estrogens, Conjugated (USP)