Time for phenytoin concentration to peak: consequences of first-order and zero-order absorption.
An increase in the time required to achieve the peak plasma concentration is observed following the oral administration of increasing doses of phenytoin. Zero-order absorption is the usual explanation for this observation. The presence of Michaelis-Menten elimination also increases the peak time when absorption is first order. The contribution of each of these mechanisms in vivo is unknown.
McCauley
D L
DL
Division of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco 94143-0622.
Tozer
T N
TN
Winter
M E
ME
D000284:Administration, Oral; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008954:Models, Biological; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
D010672:Phenytoin