[Development of a Soviet diagnostic kit for determining class M immunoglobulins to the hepatitis A virus by immunoenzyme analysis (a test system for anti-HAV IgM)].
A new test system Diagn-A-Hep for the laboratory diagnosis of hepatitis A (HA) by means of the enzyme immunoassay has been developed at the Institute of Poliomyelitis and Viral Encephalitides (Moscow). The sensitivity and specificity of the newly developed test system have proved to be similar to those of the well-known commercial diagnostic system HAVAB manufactured by Abbott Laboratories (USA). Diagn-A-Hep permits the diagnosis of HA with 96-100% effectiveness both in patients with the acute form of the disease and in patients with its anicteric or inapparent forms. This system is simple and convenient, it may be employed in inadequately equipped laboratories or even under field conditions. The rules for the selection of immunobiological preparations to be included in the test system have been worked out.
Donets
M A
MA
Nel'ga
I V
IV
Grishina
G K
GK
Korolev
M B
MB
Kusov
Iu Iu
IuIu
D000327:Adsorption; D000914:Antibodies, Viral / Q000032:analysis*; D005069:Evaluation Studies as Topic; D006506:Hepatitis A / Q000175:diagnosis; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques / Q000295:instrumentation / Q000592:standards; D007075:Immunoglobulin M / Q000032:analysis*; D011933:Reagent Kits, Diagnostic / Q000592:standards; D012015:Reference Standards; D014586:USSR
D000914:Antibodies, Viral; D007075:Immunoglobulin M; D011933:Reagent Kits, Diagnostic
Razrabotka otechestvennogo diagnosticheskogo komplekta dlia opredeleniia immunoglobulinov klassa M k virusu gepatita A immunofermentnym analizom (test-sistema na anti-VGA IgM).