title: Changes in bronchial response after Sendai virus infection in guinea pigs.
abstract: Enhanced bronchial reactivity to inhaled histamine was observed in guinea pigs infected with Sendai virus with concomitant decrease of beta-adrenergic receptor density in the pulmonary parenchyma 2 to 3 weeks after the inoculation. Histologic examination of the bronchi showed shedding of epithelial cells with a marked infiltration of mononuclear cells. These observations suggest that damage of the bronchial epithelium and decreased density of beta-adrenergic receptor may be the causes of observed bronchial reactivity.
authors.affiliation: Department of Medicine and Clinical Immunology, Dokkyo University School of Medicine, Tochigi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ohashi
authors.forename: S
authors.initials: S
authors.lastname: Motojima
authors.forename: K
authors.initials: K
authors.lastname: Yamanouchi
authors.forename: S
authors.initials: S
authors.lastname: Makino
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001980:Bronchi / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D004848:Epithelium / Q000473:pathology; D006168:Guinea Pigs; D006632:Histamine / Q000008:administration & dosage; D008297:Male; D010222:Parainfluenza Virus 1, Human; D018184:Paramyxoviridae Infections / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral; D006632:Histamine