Antibody to herpes simplex virus (HSV) ICP-35 proteins after HSV challenge of animals immunized with HSV subunit vaccines.
The serological response to the ICP-35 group of herpes simplex virus type 2 (HSV-2) proteins was examined 30 d after vaginal challenge with HSV-2 of guinea pigs previously immunized with HSV glycoproteins. Detection of antibodies to ICP-35 proteins correlated best with the magnitude of vaginal viral replication. Animals that developed antibody to ICP-35 proteins had more-frequent recurrences (P less than .0002) that were of longer duration (P less than .005) than animals that did not. By covariate analysis the number of recurrences appeared to be related to the severity of the acute disease, inversely related to the enzyme-linked immunosorbent assay titer of antibody to HSV glycoproteins, and related to the detection of antibody to ICP-35 proteins. The duration of recurrent disease, however, could only be correlated with the presence of antibody to ICP-35 proteins. Detection of antibody to ICP-35 proteins is thus a useful prognostic indicator for identifying animals that developed more-severe recurrent disease.
Bernstein
D I
DI
James N. Gamble Institute of Medical Research, Cincinnati, Ohio 45219.
Stanberry
L R
LR
Kappes
J C
JC
Burke
R L
RL
Myers
M G
MG
D000208:Acute Disease; D000704:Analysis of Variance; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000276:immunology / Q000517:prevention & control*; D007118:Immunoassay; D009500:Neutralization Tests; D012008:Recurrence; D018139:Simplexvirus / Q000276:immunology* / Q000502:physiology; D014764:Viral Proteins / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*; D014779:Virus Replication
D000914:Antibodies, Viral; D014764:Viral Proteins; D014765:Viral Vaccines; C056094:herpes simplex virus type 2 protein ICP35