title: Cosinor analysis of diurnal changes of the reduced glutathione level in the blood, brain, liver and kidneys of mice, induced by ACTH administration.
abstract: The influence of a single dose of ACTH(100 I.U. /kg body weight) on the diurnal rhythm of reduced glutathione (GSH) was studied in the blood and brain, liver and kidney homogenates of male mice. Cosinor analysis revealed that ACTH induces changes in the mean diurnal amount of GSH in the blood, brain, liver and kidneys. At the same time, GSH amplitudes in the blood and kidneys increased significantly, whereas in the case of brain and liver they decreased markedly. Moreover, it was found that ACTH induces a shift in GSH acrophases in the blood, brain, liver and kidneys as compared with the control values.
authors.affiliation: Department of Animal Physiology, Teacher Training College, Kraków, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Lach
authors.forename: J
authors.initials: J
authors.lastname: Surowiak
authors.forename: K
authors.initials: K
authors.lastname: Dziubek
authors.forename: S
authors.initials: S
authors.lastname: Krawczyk
authors.forename: W
authors.initials: W
authors.lastname: Szaroma
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002940:Circadian Rhythm / Q000187:drug effects*; D005978:Glutathione / Q000097:blood / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D014018:Tissue Distribution
chemical_list: D000324:Adrenocorticotropic Hormone; D005978:Glutathione