title: Preparation of [11C]carbon dioxide from [11C]cyanide.
abstract: [11C]Carbon dioxide was prepared from [11C]cyanide. First, [11C]CH4 was produced by the (p, alpha) reaction on a N2/H2 mixture and was converted to [11C]CN- by reaction with ammonia over platinum at 1273 K. The [11C]CN- was adsorbed on a cobalt(II, III) oxide/ceramic furnace material at room temperature and was subsequently converted to [11C]CO2 by heating the cobalt(II, III) oxide to 948 K over a 10 min period and collecting the [11C]CO2 in a trap at 77 K. Specific activities as high as 600 mCi/mumol at end of bombardment (EOB) were obtained in a 15 microA irradiation for 10 min.
authors.affiliation: Cyclotron Facility, Baumritter Institute of Nuclear Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140.
authors.forename: T E
authors.initials: TE
authors.lastname: Boothe
authors.forename: R D
authors.initials: RD
authors.lastname: Finn
authors.forename: P J
authors.initials: PJ
authors.lastname: Kothari
authors.forename: A M
authors.initials: AM
authors.lastname: Emran
mesh_terms: D002245:Carbon Dioxide / Q000138:chemical synthesis*; D002250:Carbon Radioisotopes; D002851:Chromatography, High Pressure Liquid; D003486:Cyanides; D007202:Indicators and Reagents; D007553:Isotope Labeling / Q000379:methods*
chemical_list: D002250:Carbon Radioisotopes; D003486:Cyanides; D007202:Indicators and Reagents; D002245:Carbon Dioxide