[Photodynamic laser tumor therapy with a hematoporphyrin derivative in spinocellular carcinoma of the external ear].
Haematoporphyrine-derivative (hpd) selectively photosensitises malignant tumours following intravenous application. 48 hours after injection of hpd an integral laser-light application of the tumour and the surrounding normal tissue was performed. We report on the successful administration of this photodynamic therapy in a patient with a spinocellular carcinoma of the auricle. 16 days after therapy the tumour showed a complete response without damage of the also irradiated surrounding normal tissue. Apart from a temporary sensitivity to light no side effects of the therapy were seen.
Feyh
J
J
Klinik und Poliklinik für Hals-, Nasen-Ohrenheilkunde, Klinikum Grosshadern, Ludwig-Maximilians-Universität München.
Goetz
A
A
Martin
F
F
Lumper
W
W
Müller
W
W
Brendel
W
W
Kastenbauer
E
E
D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D004428:Ear Neoplasms / Q000188:drug therapy*; D004431:Ear, External / Q000187:drug effects; D005500:Follow-Up Studies; D006414:Hematoporphyrin Photoradiation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy
Photodynamische Lasertumortherapie mit Hämatoporphyrin-Derivat (HpD) eines Spinozellulären Karzinomes der Ohrmuschel.