[Self stimulation against a background of action of blockers of the synthesis of proteins and oligopeptides].
The experiments on rabbits have demonstrated that blockade of protein synthesis by the administration of cycloheximide and actinomycin D abolishes self-stimulation in the central nervous system. The treatment with ACTH fragment (ACTH4-10) restored the self-stimulation. Unlike ACTH, injections of pentagastrin, Met-enkephalin, Leu-enkephalin and cholecystokinin were ineffective. The present study shows that ACTH4-10 plays an important role in genetic determination of self-stimulation behaviour.
Burchuladze
R A
RA
Salieva
R M
RM
Koshelev
S G
SG
Samko
Iu N
IuN
D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D008297:Male; D009842:Oligopeptides / Q000096:biosynthesis*; D010446:Peptide Fragments / Q000502:physiology; D014176:Protein Biosynthesis; D011817:Rabbits; D012653:Self Stimulation / Q000187:drug effects / Q000502:physiology*
D009842:Oligopeptides; D010446:Peptide Fragments; D003609:Dactinomycin; D000324:Adrenocorticotropic Hormone; D003513:Cycloheximide; C011394:ACTH (4-10)
Samostimuliatsiia na fone deĭstviia blokatorov sinteza belkov i oligopeptidov.