Effect of subacute administration of three organophosphorus pesticides on the hepatic phosphatases under various nutritional conditions.
In developing countries, extensive use of pesticides to meet with increased agricultural needs is inevitable and the indiscriminate use has led to several toxicological implications in humans. The toxic effects, however, to a large extent depend on the nutritional status of the individuals. In the present work, the hepatic susceptibility to pesticide toxicity has been studied in experimental animals maintained on diets containing different levels of protein for a period of 3 weeks. Along with protein deprivation, the rats were also exposed to three organophosphorus pesticides, viz., parathion, malathion, and phosalone, individually at various doses for the same time period. Phosphatases, the functionally important enzymes of the liver, were estimated and the results obtained indicated that protein deprivation further aggravated the pesticide-induced effects on the hepatic phosphatases.
Bulusu
S
S
Department of Biochemistry and Nutrition, All India Institute of Hygiene and Public Health, Government of India, Calcutta.
Chakravarty
I
I
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004044:Dietary Proteins / Q000378:metabolism; D005247:Feeding Behavior / Q000187:drug effects; D006128:Growth / Q000187:drug effects; D007306:Insecticides / Q000494:pharmacology*; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects / Q000201:enzymology*; D008294:Malathion / Q000494:pharmacology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D009946:Organothiophosphorus Compounds / Q000494:pharmacology; D010278:Parathion / Q000494:pharmacology; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D051381:Rats
D004044:Dietary Proteins; D007306:Insecticides; D009946:Organothiophosphorus Compounds; C003117:phosalone; D010278:Parathion; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D010744:Phosphoric Monoester Hydrolases; D008294:Malathion