Antiviral activity of flavones and potentiation by ascorbate.
We compared the anti-poliovirus activities of three flavones, quercetin, luteolin and 3-methylquercetin, which differ only at ring position 3. 3-Methylquercetin was the most potent compound. Quercetin exhibited antiviral activity only when protected against oxidative degradation by ascorbate. The antiviral activity of luteolin was comparable to that of ascorbate-stabilized quercetin.
Vrijsen
R
R
Department of Microbiology and Hygiene, Vrije Universiteit Brussel, Belgium.
Everaert
L
L
Boeyé
A
A
D000998:Antiviral Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D004357:Drug Synergism; D005419:Flavonoids / Q000494:pharmacology*; D044948:Flavonols; D047311:Luteolin; D010084:Oxidation-Reduction; D017955:Poliovirus / Q000187:drug effects / Q000502:physiology; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D005419:Flavonoids; D044948:Flavonols; C047368:3-methylquercetin; D011794:Quercetin; D047311:Luteolin; D001205:Ascorbic Acid