title: Beta-and alpha-adrenergic blockade and metabolic responses to insulin induced hypoglycaemia in diabetics.
abstract: The metabolic, autonomic and symptomatic effects of labetalol and metoprolol in comparison with placebo, were studied during insulin induced hypoglycaemia in 5 non-insulin dependent diabetics. Both drugs suppressed the expected increase in heart rate during hypoglycaemia, but did not affect awareness of hypoglycaemic symptoms. Neither drug produced a rise in blood pressure during hypoglycaemia nor delayed the recovery from insulin-induced hypoglycaemia. In both there was no inhibition of release of gluconeogenic substrates such as free fatty acids. The results indicate that both metoprolol, a selective beta-blocker, and labetalol, a combined alpha beta-blocker, do not impair awareness of hypoglycaemia nor alter the metabolic response to hypoglycaemia in diabetics.
authors.affiliation: Department of Medicine, University of Birmingham, UK.
authors.forename: O
authors.initials: O
authors.lastname: Odugbesan
authors.forename: M
authors.initials: M
authors.lastname: Toop
authors.forename: A H
authors.initials: AH
authors.lastname: Barnett
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006801:Humans; D007003:Hypoglycemia; D007328:Insulin; D007741:Labetalol / Q000494:pharmacology*; D008790:Metoprolol / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D008790:Metoprolol; D007741:Labetalol