Effect of angiotensin-converting enzyme inhibitors captopril and enalapril on cAMP content of specific brain areas in spontaneously hypertensive rats.
1. The influence of two angiotensin-converting enzyme inhibitors, captopril and enalapril, on the cAMP content of microdissected brain areas was examined in spontaneously hypertensive rats. Both drugs depleted systolic arterial blood pressure significantly. 2. Captopril and enalapril increased the level of cAMP in catecholaminergic cell groups in the lower brain-stem. Captopril was more effective in the substantia nigra, while enalapril treatment resulted in high cAMP levels in the ventrolateral medulla oblongata (A1 catecholaminergic cell group). 3. Both drugs, especially captopril, depleted cAMP content in the cingulate cortex. 4. No changes in cAMP levels were measured in the primary baroreceptor centre (nucleus of the solitary tract) following either captopril or enalapril treatment.
Geiger
H
H
Medical Clinic, University of Würzburg, Germany.
Bahner
U
U
Palkovits
M
M
Heidland
A
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002216:Captopril / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D004656:Enalapril / Q000494:pharmacology*; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR
D004656:Enalapril; D002216:Captopril; D000242:Cyclic AMP