title: Humoral and cellular immunity to varicella-zoster virus glycoprotein gpI and to a non-glycosylated protein, p170, in the strain 2 guinea-pig.
abstract: Strain 2 guinea-pigs were inoculated with infectious varicella-zoster virus (VZV) or with immunoaffinity-purified proteins of VZV. Monoclonal antibodies to the VZV gpI (90,000/58,000 complex) and to a non-glycosylated protein, p170, were used to prepare the polypeptide antigens. Humoral and cell-mediated immune responses to the infectious virus were compared with those elicited by the gpI and p170 proteins. Both VZV IgG antibody production and T lymphocyte proliferation to VZV were detected after immunization with infectious VZV and with VZV proteins. The antibody and T lymphocyte responses waned after protein immunization in comparison with the responses induced by infectious VZV but were detected again immediately after reimmunization with gpI or p170.
authors.affiliation: Department of Pediatrics, Stanford University School of Medicine, California 94305.
authors.forename: A M
authors.initials: AM
authors.lastname: Arvin
authors.forename: S M
authors.initials: SM
authors.lastname: Solem
authors.forename: C M
authors.initials: CM
authors.lastname: Koropchak
authors.forename: E
authors.initials: E
authors.lastname: Kinney-Thomas
authors.forename: S G
authors.initials: SG
authors.lastname: Paryani
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000917:Antibody Formation; D006168:Guinea Pigs; D014645:Herpesvirus 3, Human / Q000276:immunology*; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000032:analysis; D007700:Kinetics; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D014764:Viral Proteins / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D014764:Viral Proteins