Novel combination of c-myc, N-myc and N-ras oncogene alteration in brain tumors.
We have examined forty human brain tumors (neoplasias presenting an important incidence in Mexico), for cellular myc (c-myc), N-myc and N-ras proto-oncogene alterations. An elevated amplification and/or rearrangement of the oncogenes was detected in most samples (60% presenting alteration for c-myc, 54% for N-myc, 6% for N-ras and 60% for ras-related genes). The tumors were of different histological types and for some of them we detected either amplification and/or rearrangement of the oncogenes. We describe, for the first time, the alterations of two related genes (c-myc and N-myc) in the same tumor samples; in 64% of the analyzed samples, oncogene alterations were accompanied by enhanced expression of N-myc and ras-related genes. These results suggest an important role for c-myc, N-myc and N-ras oncogenes, in the development and progression of brain tumors.
Sauceda
R
R
Department of Genetics and Molecular Biology, CINVESTAV-IPN, Mexico, D.F.
Ocadiz
R
R
Gutierrez
A L
AL
Salcedo
M
M
Ortega
V
V
Figueroa
H H
HH
Gariglio
P
P
D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics*; D004262:DNA Restriction Enzymes; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005784:Gene Amplification; D011905:Genes, ras; D006801:Humans; D008297:Male; D008875:Middle Aged; D009710:Nucleotide Mapping; D009857:Oncogenes; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes
D004273:DNA, Neoplasm; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D004262:DNA Restriction Enzymes