title: Tumor-promoting activity of extracts of human semen in SENCAR mice.
abstract: Application of ether extracts of pooled human semen that induce Epstein-Barr virus (EBV) activation promoted skin tumor production in female SENCAR mice previously treated with 100 micrograms of 7, 12-dimethylbenz(a)anthracene (DMBA). Twice-weekly applications of 60 micrograms ether extract samples produced papillomas in SENCAR mice. Several samples of human semen were tested to determine the relationship between tumor-promoting activity and EBV activation in human semen. Pooled human semen that induced more than 10% EBV activation effectively promoted tumor production, but samples that induced less than 0.1% EBV activation were ineffective.
authors.affiliation: Department of Microbiology, Faculty of Medicine, Kyoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Kanaoka
authors.forename: O
authors.initials: O
authors.lastname: Yoshida
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002472:Cell Transformation, Viral / Q000187:drug effects*; D003043:Cocarcinogenesis; D005260:Female; D004854:Herpesvirus 4, Human / Q000254:growth & development*; D006801:Humans; D051379:Mice; D012661:Semen / Q000032:analysis*; D012878:Skin Neoplasms / Q000139:chemically induced*; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D015127:9,10-Dimethyl-1,2-benzanthracene