Duodenal polyposis and malignancy in a case of familial polyposis coli.
Familial polyposis coli is characterized by progressive adenomatosis with ultimate progression to colon cancer. It is becoming clear that these patients also have a high incidence of upper gastrointestinal adenomatous polyps, with some developing periampullary malignancies similar to those seen in Gardner's syndrome. This has led to recommendations for periodic endoscopic screening of asymptomatic polyposis patients. We report a patient with familial polyposis coli who developed an adenocarcinoma in the distal duodenum. This case points out the importance of screening the upper gastrointestinal tract in patients at risk.
Buchi
K N
KN
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City.
Becker
J M
JM
Burt
R W
RW
D000230:Adenocarcinoma / Q000473:pathology* / Q000517:prevention & control; D011125:Adenomatous Polyposis Coli / Q000473:pathology* / Q000601:surgery; D003082:Colectomy; D004379:Duodenal Neoplasms / Q000473:pathology* / Q000517:prevention & control; D004724:Endoscopy; D006801:Humans; D007417:Intestinal Polyps / Q000473:pathology* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D012306:Risk