title: Phase II pilot study with cisplatin, etoposide, and continuous-infusion 5-fluorouracil in metastatic non-small cell lung cancer.
abstract: A pilot study was conducted using a combination of cisplatin (70 mg/m2 i.v., day 1), etoposide (60 mg/m2 i.v., days 1 through 5), continuous-infusion 5-fluorouracil (800 mg/m2 i.v., days 1 through 5), and allopurinol (600 mg p.o., days 1 through 7). Treatment was repeated every 3-4 weeks. Ten patients with metastatic non-small cell lung cancer were treated. Significant toxicities were observed, including electrocardiographic changes simulating acute myocardial infarction in three patients. There was no objective response, therefore the study was closed early according to its design.
authors.affiliation: Department of Medical Oncology, University of Texas M. D. Anderson Hospital and Tumor Institute, Houston 77030.
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: H M
authors.initials: HM
authors.lastname: Dhingra
authors.forename: D F
authors.initials: DF
authors.lastname: Chiuten
authors.forename: P Y
authors.initials: PY
authors.lastname: Holoye
authors.forename: D
authors.initials: D
authors.lastname: Jeffries
authors.forename: W K
authors.initials: WK
authors.lastname: Murphy
authors.forename: T
authors.initials: T
authors.lastname: Umsawasdi
authors.forename: J A
authors.initials: JA
authors.lastname: Neidhart
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001773:Blood Cells / Q000187:drug effects; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D004341:Drug Evaluation; D004562:Electrocardiography; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006321:Heart / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D009362:Neoplasm Metastasis
chemical_list: D005047:Etoposide; D002945:Cisplatin; D005472:Fluorouracil