title: Antibody reactivity with Skinner HSV vaccine.
abstract: Antibody reactivity against herpes simplex virus (HSV) was investigated in 15 subjects who received three subcutaneous immunisations with Skinner HSV vaccine. Humoral antibody responses were detected against type 1 HSV in every subject and against type 2 HSV in all but one subject; immuno-precipitating antibody responses were infrequently detected. There was no antibody reactivity against host-cell (MRC-5), foetal calf serum or rubella virus antigen. None of the vaccinated subjects developed clinical evidence of herpes genitalis.
authors.affiliation: Department of Medical Microbiology, Medical School, University of Birmingham, UK.
authors.forename: E M
authors.initials: EM
authors.lastname: Muniu
authors.forename: J
authors.initials: J
authors.lastname: Durham
authors.forename: D
authors.initials: D
authors.lastname: Shariff
authors.forename: C E
authors.initials: CE
authors.lastname: Hartley
authors.forename: A
authors.initials: A
authors.lastname: Fuller
authors.forename: J
authors.initials: J
authors.lastname: Melling
authors.forename: C
authors.initials: C
authors.lastname: Wiblin
authors.forename: G
authors.initials: G
authors.lastname: Wilkins
authors.forename: A
authors.initials: A
authors.lastname: Buchan
authors.forename: G R
authors.initials: GR
authors.lastname: Skinner
mesh_terms: D000914:Antibodies, Viral / Q000096:biosynthesis*; D000956:Antigens, Viral / Q000276:immunology*; D006558:Herpes Genitalis / Q000517:prevention & control*; D006801:Humans; D007118:Immunoassay; D005779:Immunodiffusion; D009500:Neutralization Tests; D011863:Radioimmunoassay; D012412:Rubella virus / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D014765:Viral Vaccines; C040901:rubella antibodies