title: The effect of dietary fiber on the bioavailability of digoxin in capsules.
abstract: Sixteen healthy volunteers were regularly given 0.4 mg of digoxin daily as two capsules with breakfast. After ten days during which breakfast was supplemented with 11 g of bran fiber, steady-state predose mean serum digoxin was lower (0.89 +/- 0.19 versus 0.84 +/- 0.18 ng/mL, P less than .05) and mean 24-hour area under curve determination was lower (30.5 +/- 6.1 versus 28.4 +/- 6.0 ng X hr/mL, P less than .05) than during the control period without bran. Height and time of peak serum digoxin, and 24-hour urinary digoxin were not significantly different. The 6 to 7% reduction in digoxin absorption from capsules is less than that reported from tablets and is probably clinically unimportant.
authors.affiliation: Division of Clinical Pharmacology, University of Massachusetts Medical Center, Worcester 01605.
authors.forename: B F
authors.initials: BF
authors.lastname: Johnson
authors.forename: S M
authors.initials: SM
authors.lastname: Rodin
authors.forename: K
authors.initials: K
authors.lastname: Hoch
authors.forename: V
authors.initials: V
authors.lastname: Shekar
mesh_terms: D000328:Adult; D001682:Biological Availability; D002214:Capsules; D004043:Dietary Fiber / Q000494:pharmacology*; D004077:Digoxin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D002214:Capsules; D004043:Dietary Fiber; D004077:Digoxin