Human ubiquitin genes: one member of the UbB gene subfamily is a tetrameric non-processed pseudogene.
The human ubiquitin gene family consists of three subfamilies. One of these, the UbB subfamily, includes a functional gene coding for a polyubiquitin protein that contains three ubiquitin copies tandemly repeated, as well as three pseudogenes of the processed type. We have now isolated a fifth human UbB type gene, different from any of the previously identified ones. This newly isolated gene is a tetrameric pseudogene which has presumably arisen by unequal crossing-over of two ancestral trimeric alleles. Southern blotting data indicate that all members of the human UbB gene subfamily are now accounted for.
Cowland
J B
JB
Laboratory of Molecular Biology, Statens Seruminstitut, Copenhagen S, Denmark.
Wiborg
O
O
Vuust
J
J
D000328:Adult; D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004926:Escherichia coli / Q000235:genetics; D005796:Genes; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D011544:Pseudogenes; D014452:Ubiquitins / Q000235:genetics*
D046911:Macromolecular Substances; D014452:Ubiquitins