Etretinate modulates the leukotriene B4 induced intra-epidermal accumulation of polymorphonuclear leukocytes.
The effect of etretinate on the intra-epidermal accumulation of polymorphonuclear leukocytes following epicutaneous application of leukotriene B4 was studied in five psoriatic patients. Polymorphonuclear leukocytes were quantified using the marker enzyme elastase. An inverse relationship was found between the dosage of etretinate and the number of infiltrating polymorphonuclear leukocytes.
Lammers
A M
AM
Department of Dermatology, University of Nijmegen, The Netherlands.
van de Kerkhof
P C
PC
D000279:Administration, Cutaneous; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005050:Etretinate / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D011565:Psoriasis / Q000188:drug therapy; D012867:Skin / Q000187:drug effects* / Q000473:pathology
D007975:Leukotriene B4; D005050:Etretinate