title: Hypercalcemia and abnormal 1,25-dihydroxyvitamin D concentrations in leprosy.
abstract: Two patients with lepromatous leprosy and hypercalcemia are presented. Serum immunoreactive parathyroid hormone and urinary cyclic adenosine monophosphate concentrations were suppressed. Serum 1,25-dihydroxyvitamin D [1,25-(OH)2D] concentrations were elevated in one patient and normal in the other. Urinary hydroxyproline excretion was slightly high in both patients. Hypercalcemia resolved excretion was slightly high in both patients. Hypercalcemia resolved with prednisone therapy. Abnormal 1,25-(OH)2D production and/or metabolism may play a role in the pathogenesis of hypercalcemia in some patients with leprosy.
authors.affiliation: Department of Internal Medicine, Los Angeles County/University of Southern California Medical Center.
authors.forename: E
authors.initials: E
authors.lastname: Ryzen
authors.forename: T H
authors.initials: TH
authors.lastname: Rea
authors.forename: F R
authors.initials: FR
authors.lastname: Singer
mesh_terms: D000328:Adult; D002117:Calcitriol / Q000097:blood*; D000242:Cyclic AMP / Q000652:urine; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D006934:Hypercalcemia / Q000209:etiology*; D007918:Leprosy / Q000150:complications* / Q000378:metabolism; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood
chemical_list: D010281:Parathyroid Hormone; D000242:Cyclic AMP; D002117:Calcitriol; D006909:Hydroxyproline