title: Regulation of diacylglycerol kinase in the transition from quiescence to proliferation in Dictyostelium discoideum.
abstract: Diacylglycerol kinase and phosphatidylinositol kinase were examined in stationary phase D. discoideum amoeba induced to synchronously proliferate by dilution into fresh medium. Membrane bound diacylglycerol kinase activity showed a rapid and transitory 3-5 fold increase in the preproliferative interphase while phosphatidylinositol kinase activity was kept quite constant during the same period. The changes in diacylglycerol kinase activity seem to be due to a translocation of the enzyme from the soluble to the particulate cell compartments.
authors.affiliation: Instituto de Investigaciones Biomédicas, CSIC y Departamento de Bioquímica, F. Medicina UAM, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Jímenez
authors.forename: M M
authors.initials: MM
authors.lastname: Van Lookeren Campagne
authors.forename: A
authors.initials: A
authors.lastname: Pestaña
authors.forename: M
authors.initials: M
authors.lastname: Fernández-Renart
mesh_terms: D019870:1-Phosphatidylinositol 4-Kinase; D002455:Cell Division; D002462:Cell Membrane / Q000201:enzymology; D003600:Cytosol / Q000378:metabolism; D019852:Diacylglycerol Kinase; D004023:Dictyostelium / Q000166:cytology / Q000201:enzymology*; D007700:Kinetics; D008081:Liposomes / Q000378:metabolism; D010712:Phosphatidic Acids / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000378:metabolism; D010770:Phosphotransferases / Q000378:metabolism*
chemical_list: D008081:Liposomes; D010712:Phosphatidic Acids; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; C037178:phosphatidylinositol 4-phosphate; D010770:Phosphotransferases; D019852:Diacylglycerol Kinase; D019870:1-Phosphatidylinositol 4-Kinase