Effects of chronic dietary lithium on phosphatidylinositol pathway in heart and arteries of DOCA-salt hypertensive rats.
The sensitivity of the phosphatidylinositol (PI) pathway was evaluated in slices of atria (A), ventricles (V), and mesenteric artery (MA) in normotensive (NT) and DOCA-salt hypertensive (DOCA-HT) rats. During norepinephrine (NE) activation, the PI reactivity was two to three times greater in A, V, and MA of HT rats compared to NT rats. The long-term (2 weeks) administration of dietary lithium (Li) reduced the activation of PI by NE in left A and right V but caused no changes in MA of HT rats. The Li-treated hypertensive rats were also characterized by a lower systolic blood pressure and a lower ratio of ventricular weight/body weight. Plasma epinephrine (E) levels that were higher in HT rats were normalized in DOCA-HT + Li-treated rats, while the NE levels remained elevated in the DOCA-HT + Li group.
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Départment de Physiologie, Faculté de Médicine, Université de Montréal, PQ, Canada.
de Champlain
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J
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone; D004837:Epinephrine / Q000097:blood; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism*; D007295:Inositol Phosphates / Q000378:metabolism; D008094:Lithium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D016651:Lithium Carbonate; D008638:Mesenteric Arteries / Q000032:analysis / Q000378:metabolism*; D009206:Myocardium / Q000032:analysis / Q000378:metabolism*; D009638:Norepinephrine / Q000097:blood; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism
D007295:Inositol Phosphates; D010716:Phosphatidylinositols; D011942:Receptors, Adrenergic, alpha; D016651:Lithium Carbonate; D003900:Desoxycorticosterone; D008094:Lithium; D009638:Norepinephrine; D004837:Epinephrine