[Effect of nimodipine on plasma catecholamines and perioperative endocrine stress parameters].
The influence of nimodipine on plasma-catecholamines, ADH, ACTH and cortisol during standardized, modified neurolept-anaesthesia was investigated in 20 patients for major abdominal and thoracic surgery. The application of nimodipine led to an intra- and postoperative increase in both adrenaline and noradrenaline. No influence could be demonstrated on ADH, ACTH or cortisol. Group-levels of MAP were lower in the nimodipine-group. No statistical differences became obvious for HR, glucose, lactate and free glycerol. The increases in adrenaline and noradrenaline can be attributed to a cardiocirculatory rebound-phenomenon due to the vasodilative properties of the substance. Under the conditions of adequate fentanylanalgesia, no influence of nimodipine on ADH, ACTH or cortisol was found.
Adams
H A
HA
Abteilung für Anästhesiologie und Operative Intensivmedizin, Klinikum der Justus-Liebig-Universität Giessen.
Müller
H
H
von Bormann
B
B
Börner
U
U
Hempelmann
G
G
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001786:Blood Glucose / Q000378:metabolism; D004837:Epinephrine / Q000097:blood*; D005260:Female; D005990:Glycerol / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D009553:Nimodipine / Q000008:administration & dosage*; D009638:Norepinephrine / Q000097:blood*; D011292:Premedication; D013312:Stress, Physiological / Q000097:blood*; D014667:Vasopressins / Q000097:blood
D001786:Blood Glucose; D007773:Lactates; D014667:Vasopressins; D019344:Lactic Acid; D009553:Nimodipine; D000324:Adrenocorticotropic Hormone; D005990:Glycerol; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine
Der Einfluss von Nimodipin auf Plasma-Katecholamine und perioperative endokrine Stress-Parameter.