[Effect of corticotropin and hydrocortisone on carbohydrate metabolism in skeletal muscles].
The intraperitoneal administration of corticotropin (ACTH) in the rate of 1 and 2 units per 100 g of body weight and that of hydrocortisone in the rate of 1 mg and 5 mg per 100 g body weight were studied for their effects on carbohydrate metabolism rate in musculus gastrocnemius as well as on the level of 11-oxycorticosteroids in blood plasma of rats. The glycogen level in muscles was found to rise 3 hours after ACTH and hydrocortisone administration and it correlated with the hydrocortisone level increase in blood plasma (r = 0.714 and 0.863, respectively); the activity of pyruvate kinase decreased. Simultaneously ACTH did not change while hydrocortisone lowered the phosphorylase activity and the content of both fructose-6-phosphate and lactate.
Korkach
V I
VI
D015062:11-Hydroxycorticosteroids / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D050260:Carbohydrate Metabolism; D003345:Corticosterone / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D007773:Lactates / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D051381:Rats
D015062:11-Hydroxycorticosteroids; D007773:Lactates; D000324:Adrenocorticotropic Hormone; D006003:Glycogen; D003345:Corticosterone; D006854:Hydrocortisone
Vliianie kortikotropina i gidrokortizona na uglevodnyĭ obmen v skeletnykh myshtsakh.