Myocardial hypertrophy: the effect of sodium and the role of sympathetic nervous system activity.
Dietary sodium and the myocardial alpha 1-receptor have been implicated in the hypertrophic response of myocardial tissue. Alterations in sodium homeostasis have been demonstrated to influence sympathetic nervous function, centrally and peripherally. In this investigation, we have examined the effect of dietary sodium on the development of myocardial hypertrophy; and the role of sympathetic neuroeffector mechanisms in the hypertrophic response. Studies were performed in three groups of uninephrectomized rats: A-regular diet; B-1% saline/regular diet; C-1% Saline/doca/regular diet. Groups A and B did not develop systemic hypertension (SHT). Saline treatment increased heart weight and the density of surface alpha 1-receptors; myocardial norepinephrine (NE) was reduced. Group C developed SHT. Heart weight was greatest in Group C; and myocardial NE was severely depleted. Downregulation of myocardial alpha 1-receptors, a finding consistent with the hyperadrenergic state, was observed in Group C. Our results suggest dietary sodium may modulate hypertrophic response in myocardial tissue, by altering sympathetic neuroeffector mechanisms.
Meggs
L G
LG
Department of Medicine, New York Medical College, Valhalla 10595.
Ben-Ari
J
J
Gammon
D
D
Goodman
A I
AI
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006332:Cardiomegaly / Q000139:chemically induced*; D003900:Desoxycorticosterone / Q000031:analogs & derivatives; D006973:Hypertension / Q000139:chemically induced; D007457:Iodine Radioisotopes; D008297:Male; D009206:Myocardium / Q000032:analysis / Q000473:pathology; D009638:Norepinephrine / Q000032:analysis; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000032:analysis / Q000187:drug effects; D012982:Sodium, Dietary / Q000009:adverse effects* / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*
D007457:Iodine Radioisotopes; D011942:Receptors, Adrenergic, alpha; D012982:Sodium, Dietary; C019323:deoxycortone pivalate; D003900:Desoxycorticosterone; D009638:Norepinephrine