title: A non-metastatic remote effect of lung carcinoma.
abstract: A 37-year-old man, who had an oat cell carcinoma of the left lung, lost in a few months a substantial part of both visual fields, on account of a destructive retinal process. This syndrome is known in the literature as a visual paraneoplastic syndrome, which clinically shows the very rapid development of a pseudoretinitis pigmentosa sine pigmento. For most of the patients described the visual problem was the presenting symptom. In contrast with most other described cases, our patient responded very well to systemic tumor treatment and his ocular process also came to a standstill after some delay. The nature of the relationship between the primary tumor and the photoreceptor destruction is not yet clear in detail. An auto-immune process probably forms the basis of the syndrome, but hormonal activity of the tumor could not be excluded in all cases.
authors.affiliation: Department of Ophthalmology, Medical Center Leeuwarden, The Netherlands.
authors.forename: B A
authors.initials: BA
authors.lastname: van der Pol
authors.forename: J T
authors.initials: JT
authors.lastname: Planten
mesh_terms: D000328:Adult; D018288:Carcinoma, Small Cell / Q000150:complications*; D004585:Electrooculography; D004596:Electroretinography; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D012164:Retinal Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D014792:Visual Acuity; D014794:Visual Fields