Rapid progressive glomerulonephritis in patients with familial Mediterranean fever.
Two patients with a long-standing history of familial Mediterranean fever (FMF) presented with gross hematuria, oliguria, and acute renal failure; both required dialysis support. Kidney biopsies from both patients revealed crescentic rapid progressive glomerulonephritis (RPGN) without amyloidosis. One patient recovered renal function with methylprednisolone pulse therapy and cyclophosamide. The second patient did not improve and required regular hemodialysis. He is asymptomatic on colchicine therapy. To our knowledge, these are the first cases documenting the presence of RPGN in patients with FMF.
Said
R
R
Department of Medicine, School of Medicine, Jordan University, Amman.
Hamzeh
Y
Y
Tarawneh
M
M
el-Khateeb
M
M
Abdeen
M
M
Shaheen
A
A
D000293:Adolescent; D001706:Biopsy; D002648:Child; D003078:Colchicine / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D010505:Familial Mediterranean Fever / Q000150:complications*; D005921:Glomerulonephritis / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D006435:Renal Dialysis
D003520:Cyclophosphamide; D003078:Colchicine; D008775:Methylprednisolone