[The prevention of the side effects of cytostatics by administering them at various times of day].
Rats bearing Pliss' lymphosarcoma revealed diurnal variations of body temperature. Cyclophosphamide and methotrexate were significantly less toxic when injected at peak temperatures than at minimal ones.
Efimov
M L
ML
Vasil'eva
G S
GS
Kovalenko
V R
VR
Panina
T G
TG
Mustafina
R Kh
RKh
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects*; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000009:adverse effects / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects / Q000633:toxicity; D009368:Neoplasm Transplantation; D051381:Rats; D013997:Time Factors
D003520:Cyclophosphamide; D008727:Methotrexate
Profilaktika pobochnogo deĭstviia tsitostatikov putem ikh vvedeniia v razlichnoe vremia sutok.