title: [Metabolic regulation of the histidine operon in Escherichia coli and Salmonella typhimurium].
abstract: Expression of the histidine operon in Escherichia coli cells in contrast to the one in Salmonella typhimurium is changed proportionally to cells growth rate on the different carbon sources. The specific activity of histidinol-dehydrogenase is repressed by addition of 19 amino acids both in Escherichia coli and Salmonella typhimurium independent of the growth medium used. Using of Escherichia coli and Salmonella typhimurium strains containing the heterologous histidine operons made possible to demonstrate the dependence of the histidine operon metabolic regulation to be determined by the operon itself but not by the specificity of the recipient cells. ppGpp was shown to be a positive regulator of the histidine operon expression in Escherichia coli.
authors.forename: B V
authors.initials: BV
authors.lastname: Perel'man
authors.forename: R S
authors.initials: RS
authors.lastname: Shakulov
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Smirnov
authors.forename: A F
authors.initials: AF
authors.lastname: Lisenkov
authors.forename: G V
authors.initials: GV
authors.lastname: Astvatsaturiants
mesh_terms: D000429:Alcohol Oxidoreductases / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics*; D005786:Gene Expression Regulation; D006639:Histidine / Q000235:genetics*; D006642:Histidinol-Phosphatase / Q000378:metabolism; D009876:Operon; D012486:Salmonella typhimurium / Q000235:genetics*; D013045:Species Specificity; D013913:Threonine Dehydratase / Q000378:metabolism; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D006639:Histidine; D000429:Alcohol Oxidoreductases; C021358:histidinol dehydrogenase; D006642:Histidinol-Phosphatase; D001618:beta-Lactamases; D013913:Threonine Dehydratase
vernacular_title: Metabolicheskaia reguliatsiia gistidinovogo operona Escherichia coli i Salmonella typhimurium.