title: Herpes simplex virus type 1 induces anterior chamber-associated immune deviation (ACAID) in mouse strains resistant to intraocular infection.
abstract: Inoculation of herpes simplex virus Type 1 into the anterior chamber of BALB/c mice induces a characteristic ocular infection involving primarily the anterior segment of virus-injected eyes and the retina of contralateral uninjected eyes. In the BALB/c strain, which is susceptible to herpetic retinitis, anti-HSV delayed hypersensitivity responses are actively suppressed, although anti-HSV antibody responses remain intact. We previously demonstrated that C57B1/6 mice, as well as (BALB/c X C57B1/6) F1 are highly resistant to HSV-1 retinitis. Studies have now been performed to determine the relationship between systemic immune responses to HSV and the resistance of C57B1/6 and the (BALB/c X C57B1/6) F1 to develop retinitis after inoculation of HSV into one anterior chamber. Despite the resistance to herpetic retinitis by B6 and F1 mice, both strains developed a pattern of systemic immune responses to HSV similar to those observed in the susceptible BALB/c mice. Therefore, resistance to retinal infection with HSV-1 does not appear to correlate with the pattern of systemic cell-mediated or humoral immune responses to intracameral HSV-1.
authors.affiliation: Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
authors.forename: J A
authors.initials: JA
authors.lastname: Whittum-Hudson
authors.forename: J S
authors.initials: JS
authors.lastname: Pepose
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000276:immunology* / Q000382:microbiology; D000914:Antibodies, Viral / Q000032:analysis; D004198:Disease Susceptibility; D006561:Herpes Simplex; D006968:Hypersensitivity, Delayed / Q000517:prevention & control*; D007165:Immunosuppression Therapy; D051379:Mice / Q000235:genetics*; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012173:Retinitis / Q000209:etiology*; D018139:Simplexvirus / Q000502:physiology*
chemical_list: D000914:Antibodies, Viral