An endogenous ligand from human CSE for the phencyclidine receptor.
A fraction which potently and specifically competed with 3H-PCP binding to rat membranes was isolated from human CSF. This substance ran just before the salts in Sephadex G-25 column and was eluted with low concentrations of acetonitrile in reverse phase HPLC, predicating that it may be a small hydrophilic compound with a MW. of less than 1,000 daltons.
Zhou
G Z
GZ
Dept. of Neurobiology, Shanghai Medical Univ.
Gong
D W
DW
Jiang
C C
CC
Yao
J L
JL
Gao
H
H
Zhu
Y X
YX
Pan
B S
BS
Zhang
A Z
AZ
D000818:Animals; D001921:Brain / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002555:Cerebrospinal Fluid / Q000378:metabolism*; D006801:Humans; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D017478:Receptors, Phencyclidine; D014020:Tissue Extracts / Q000378:metabolism
D017981:Receptors, Neurotransmitter; D011957:Receptors, Opioid; D017478:Receptors, Phencyclidine; D014020:Tissue Extracts