11C-labelled glycine: synthesis and preliminary report on its use in the investigation of intracranial tumours using positron emission tomography.
Carbon-11-labelled glycine has been prepared by a Bücherer-Strecker synthesis using [11C]cyanide, formaldehyde and ammonium carbonate. Total synthesis time, including chromatographic purification, was 30-35 min from end-of-bombardment. Radiochemical yield was 35%, based on [11C]cyanide and radiochemical purity was shown to be greater than 98% by analytical HPLC. The 11C-labelled glycine thus prepared was used along with [68Ga]EDTA and L-[methyl-11C]methionine in the visualization of an anaplastic astrocytoma by positron emission tomography.
Johnström
P
P
Karolinska Pharmacy, Stockholm, Sweden.
Stone-Elander
S
S
Ericson
K
K
Mosskin
M
M
Bergström
M
M
D001254:Astrocytoma / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D002250:Carbon Radioisotopes; D004492:Edetic Acid; D005710:Gallium Radioisotopes; D005998:Glycine; D006801:Humans; D008715:Methionine; D014055:Tomography, Emission-Computed / Q000379:methods
D002250:Carbon Radioisotopes; D005710:Gallium Radioisotopes; D004492:Edetic Acid; D008715:Methionine; D005998:Glycine