Chromosomal changes in soft-tissue sarcomas. A new diagnostic parameter.
A cytogenetic study was performed on short-term cultures from fresh surgical specimens obtained from 41 patients with soft-tissue sarcomas of various histologic origins. The results demonstrated that myxoid liposarcomas (five tumors) were associated with a specific translocation between chromosomes 12 and 16 and that synovial sarcomas (six tumors) were associated with a specific translocation between the X chromosome and chromosome 18. These chromosomal data have been used to differentiate myxoid liposarcoma from other myxoid tumors exhibiting a non-characteristic histologic picture, as well as to ascertain the diagnosis of synovial sarcoma in undifferentiated soft-tissue sarcomas. The results to date indicate that identification of specific chromosomal changes in sarcomas may provide a new diagnostic criterion for these tumors and possibly improve prognostication with regard to survival and response to treatment.
Karakousis
C P
CP
Department of Surgical Oncology, Roswell Park Memorial Institute, Buffalo, NY 14263.
Dal Cin
P
P
Turc-Carel
C
C
Limon
J
J
Sandberg
A A
AA
D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D002885:Chromosomes, Human, Pair 16; D002887:Chromosomes, Human, Pair 18; D005260:Female; D006801:Humans; D008067:Lipoma / Q000235:genetics; D008080:Liposarcoma / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012303:Ring Chromosomes; D012509:Sarcoma / Q000235:genetics*; D013584:Sarcoma, Synovial / Q000235:genetics; D012983:Soft Tissue Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic; D014960:X Chromosome