The possible involvement of changes in phosphoinositol turnover in the responses of renal sodium transport to noradrenaline.
Noradrenaline stimulated the formation of [3H]inositol monophosphates from 3H-inositol-phospholipids in rat kidney cortex slices. This response was inhibited by the alpha 1-adrenoceptor antagonist prazosin but not by the alpha 2-adrenoceptor antagonist yohimbine, suggesting that the response was mediated via an alpha 1-adrenoceptor. This is in keeping with the ability of noradrenaline to increase sodium transport in this tissue by alpha 1-adrenoceptor stimulation.
Plevin
R J
RJ
Department of Physiology and Pharmacology, University of Southampton, U.K.
Parsons
B J
BJ
Butcher
P
P
Poat
J A
JA
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D066298:In Vitro Techniques; D007295:Inositol Phosphates / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D012964:Sodium / Q000378:metabolism*; D013403:Sugar Phosphates / Q000378:metabolism*
D007295:Inositol Phosphates; D011942:Receptors, Adrenergic, alpha; D013403:Sugar Phosphates; D012964:Sodium; D009638:Norepinephrine