title: Paradoxical reactions elicited by diazepam in children with classic autism.
abstract: Administration of diazepam (10 mg i.m.) to seven children (two girls and five boys) affected by infantile autism elicited paradoxical behavioural responses. Mainly, anxiogenic effect, unsocialized aggressive behaviour and explosive aggression were dramatically increased in comparison with the same symptoms present before and after treatment. The results show for the first time that benzodiazepines may elicit paradoxical behavioural response in autistic children. The possible involvement of an altered function at the level of GABA/benzodiazepine receptor complex is discussed.
authors.affiliation: Institute of Neurology, University of Cagliari, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Marrosu
authors.forename: G
authors.initials: G
authors.lastname: Marrosu
authors.forename: M G
authors.initials: MG
authors.lastname: Rachel
authors.forename: G
authors.initials: G
authors.lastname: Biggio
mesh_terms: D000374:Aggression / Q000503:physiopathology / Q000523:psychology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy / Q000503:physiopathology; D001321:Autistic Disorder / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D002648:Child; D003975:Diazepam / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology
chemical_list: D011963:Receptors, GABA-A; D003975:Diazepam