[Adjusting the dosage of netilmicin from two measurements. Program validation].
The aim of this study is to give to clinicians a well validated usefull tool allowing an increase of safety in the monitoring of netilmicin. During the first administration of the drug, two plasmatic concentrations are measured, and input in a preprogrammed hand-held calculator. A posology and a rythm of administration are returned by the calculator. After six days of this dosage regiment, the peak and the valley concentrations are compared with those previously given by the computer as values at equilibrium. No significant difference can be observed. There is no change in plasmatic creatinine level from the first to the sixth day of treatment. So, a preprogrammed hand-held computer can be convenient and safe to monitor netilmicin.
Guedes
Y
Y
Abgrall
J F
JF
Lebot
M A
MA
Voirin
T
T
L'Azou
D
D
Dheilly
M
M
Tanguy
R L
RL
Le Garrec
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008838:Microcomputers; D008875:Middle Aged; D009428:Netilmicin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics
D009428:Netilmicin; D003404:Creatinine
Adaptation des posologies de la nétilmicine à partir de deux points. Validation d'un programme.