title: [Breast cancers, apparently non-metastatic, treated by prior chemotherapy and radiotherapy, combined with or without excision surgery. Preliminary results].
abstract: Combined treatment modality was applied in 51 consecutive patients with locally advanced breast carcinoma between December 1982 and December 1984. The treatment was started with 4 cycles of chemotherapy with combination of adriamycin, vincristine, 5-fluorouracil and cyclophosphamide. This was followed by high-energy radiotherapy (45 Gy to the breast and lymphatic areas), with or without surgery. After radiotherapy, the response rate was 76%: 39/51 (complete response 39%: 20/51). Twenty-nine patients (57%) were treated conservatively (20 treated by radiotherapy alone and 9 treated by tumorectomy with axillary dissection followed by interstitial implantation). For 22 patients (43%), the mastectomy with axillary dissection was necessary. The three year overall survival rate and disease free survival rate were 88, and 86%. Local recurrences occurred in one patient (2%). The toxicity with this combined treatment regime was low. The cosmetic results were acceptable when a conservative treatment was proposed.
authors.affiliation: Centre des tumeurs, CHU Pitié-Salpêtrière, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Touboul
authors.forename: J P
authors.initials: JP
authors.lastname: Lefranc
authors.forename: J
authors.initials: J
authors.lastname: Blondon
authors.forename: R A
authors.initials: RA
authors.lastname: Guerin
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D002277:Carcinoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000188:drug therapy / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D013997:Time Factors
vernacular_title: Cancers du sein, en apparence non métastasés, traités par chimiothérapie première et radiothérapie, associées ou non à une chirurgie d'exérèse. Résultats préliminaires.