Inhibition of infectivity and replication of HIV-2 and SIV in helper T-cells by 2',3'-dideoxynucleosides in vitro.
We have previously shown that 2',3'-dideoxynucleosides and their derivatives are potent inhibitors of the infectivity and cytopathic effect mediated by human immunodeficiency virus type-1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS). Recently a new group of retroviruses has been found in individuals originating from the western part of Africa. One member of this group is human immunodeficiency virus type-2 (HIV-2), previously designated lymphadenopathy-associated virus type-2 (LAV-2), found in patients with an AIDS-like illness. In this report, we show that 2',3'-dideoxynucleosides including 3'-azido-2',3'-dideoxythymidine (AZT) can significantly inhibit the infectivity and/or cytopathic effect of these retroviruses in vitro. Current data provide a rationale for considering 2',3'-dideoxynucleosides and their derivatives as experimental antiviral agents in individuals with illnesses caused by these new retroviruses.
Mitsuya
H
H
Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20892.
Broder
S
S
D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D003839:Deoxyadenosines / Q000031:analogs & derivatives / Q000494:pharmacology; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000494:pharmacology; D016048:Dideoxyadenosine; D006678:HIV / Q000187:drug effects*; D066298:In Vitro Techniques; D009705:Nucleosides / Q000494:pharmacology*; D012190:Retroviridae / Q000187:drug effects* / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000382:microbiology*; D013936:Thymidine / Q000031:analogs & derivatives / Q000494:pharmacology; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects*; D016047:Zalcitabine; D015215:Zidovudine
D003839:Deoxyadenosines; D009705:Nucleosides; D014764:Viral Proteins; D003841:Deoxycytidine; D015215:Zidovudine; D016048:Dideoxyadenosine; D016047:Zalcitabine; D013936:Thymidine