title: Human immunodeficiency virus type 1 has an additional coding sequence in the central region of the genome.
abstract: Eight coding regions designated gag, pol, env, sor, R, tat, art/trs, and 3' orf have been identified in the genome of the human immunodeficiency virus type 1 (HIV-1). Several other open reading frames have the potential to encode additional viral proteins. In this study, we show that HIV-1 has another coding sequence whose product is expressed during natural infection. Unlike antibody to other HIV-1 proteins, the prevalence of antibody to the product encoded by this region is elevated in patients with acquired immune deficiency syndrome (AIDS). Because no analogous coding region has been identified in HIV-2, the antibody to the product of this coding region may serve as a marker to distinguish infection with HIV-1 from infection with HIV-2.
authors.affiliation: Department of Cancer Biology, Harvard University School of Public Health, Boston, MA 02115.
authors.forename: Z
authors.initials: Z
authors.lastname: Matsuda
authors.forename: M J
authors.initials: MJ
authors.lastname: Chou
authors.forename: M
authors.initials: M
authors.lastname: Matsuda
authors.forename: J H
authors.initials: JH
authors.lastname: Huang
authors.forename: Y M
authors.initials: YM
authors.lastname: Chen
authors.forename: R
authors.initials: R
authors.lastname: Redfield
authors.forename: K
authors.initials: K
authors.lastname: Mayer
authors.forename: M
authors.initials: M
authors.lastname: Essex
authors.forename: T H
authors.initials: TH
authors.lastname: Lee
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics* / Q000382:microbiology; D001483:Base Sequence; D004279:DNA, Viral / Q000032:analysis*; D017977:Deltaretrovirus / Q000276:immunology; D005819:Genetic Markers; D006678:HIV / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011994:Recombinant Proteins / Q000032:analysis; D014764:Viral Proteins / Q000032:analysis
chemical_list: D004279:DNA, Viral; D005819:Genetic Markers; D011994:Recombinant Proteins; D014764:Viral Proteins