[Anti-ischemia effect of enalapril in coronary heart disease. A randomized placebo-controlled double-blind study].
The anti-anginal effect of the ACE inhibitor enalapril, at a dosage of 5 mg twice a day, was tested in a randomised, placebo-controlled double-blind trial on 12 normotensive patients with proven coronary-heart disease. There was a reduction of exercise-induced ST depression by 22% already after the first dose of 5 mg. After 15 days of treatment the ST depression had decreased by 35% (P less than 0.05).
Rietbrock
N
N
Abteilung für Klinische Pharmakologie, Universität Frankfurt, Main.
Thürmann
P
P
Kirsten
R
R
Schneider
W
W
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D004656:Enalapril / Q000627:therapeutic use*; D005080:Exercise Test; D006801:Humans; D008875:Middle Aged; D010919:Placebos; D011897:Random Allocation
D010919:Placebos; D004656:Enalapril
Antiischämische Wirksamkeit von Enalapril bei koronarer Herzkrankheit. Eine randomisierte, placebo-kontrollierte Doppelblindstudie.