title: Coumarins as inhibitors of bacterial DNA gyrase.
abstract: Chlorobiocic acid and 3-(carbobenzoxyamino)-4,7-dihydroxy-8-methylcoumarin were identified as two new inhibitors of Micrococcus luteus DNA gyrase. Both compounds possess weak antibacterial activity against whole M. luteus cells which indicates that they probably lack efficient transport functions to penetrate the cell envelope.
authors.affiliation: Upjohn Company, Kalamazoo, MI 49001.
authors.forename: I W
authors.initials: IW
authors.lastname: Althaus
authors.forename: L
authors.initials: L
authors.lastname: Dolak
authors.forename: F
authors.initials: F
authors.lastname: Reusser
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology*; D004261:DNA Replication / Q000187:drug effects; D008837:Micrococcus / Q000201:enzymology*; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors
chemical_list: D000900:Anti-Bacterial Agents; D003374:Coumarins; D059005:Topoisomerase II Inhibitors; C055845:chlorobiocic acid; C055843:carbobenzoxycoumarin