title: Anti-RH immunoglobulin therapy for human immunodeficiency virus-related immune thrombocytopenic purpura.
abstract: The potential hazards of steroids in human immunodeficiency virus (HIV)-infected patients led us to evaluate the effectiveness and safety of anti-D and anti-c Ig in 17 adults with severe HIV-related immune thrombocytopenic purpura (platelet count less than 20 x 10(9)/L). The 14 Rh+ patients received 12 to 25 micrograms/kg of anti-D IgG intravenously on two consecutive days. A significant platelet rise above 50 x 10(9)/L was obtained in nine patients. Repeated boosters were performed in six cases and were effective in all cases. The 3 Rh- patients had a good response after they were given 20 mL x 2 of plasma containing potent anti-c antibodies. Therapy was well tolerated, and only one patient had significant hemolysis. These data suggest that anti-Rh IgG can be effective and safe in HIV-related thrombocytopenic purpura and that a specific interaction between the RBC antigens and the anti-Rh antibodies is required.
authors.affiliation: Department of Immunohematology, Institut National de la Santé et de la Récherche Medicale U108, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Oksenhendler
authors.forename: P
authors.initials: P
authors.lastname: Bierling
authors.forename: Y
authors.initials: Y
authors.lastname: Brossard
authors.forename: C
authors.initials: C
authors.lastname: Schenmetzler
authors.forename: P M
authors.initials: PM
authors.lastname: Girard
authors.forename: M
authors.initials: M
authors.lastname: Seligmann
authors.forename: J P
authors.initials: JP
authors.lastname: Clauvel
mesh_terms: D001327:Autoimmune Diseases / Q000209:etiology / Q000628:therapy*; D005069:Evaluation Studies as Topic; D005260:Female; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D007116:Immunization, Passive; D007518:Isoantibodies / Q000627:therapeutic use*; D008297:Male; D011696:Purpura, Thrombocytopenic / Q000209:etiology / Q000628:therapy*; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D018029:Rho(D) Immune Globulin
chemical_list: D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin