Acetylcholine receptor density and binding in murine dystrophy.
The concentration and binding characteristics of acetylcholine receptors (AChR) in sarcolemmal fractions from normal and dystrophic mice have been measured. Unlike the results following denervation, AChR concentration (per g wet weight) is unchanged and AChR affinity for two different alpha-neurotoxins is also unchanged. In contrast sarcolemmal ATPase is significantly reduced in dystrophic tissues. These data reaffirm that denervation is a poor model of dystrophy.
Kruck
T P
TP
Department of Biology, York University, Downsview, Ontario, Canada.
Logan
D M
DM
D000818:Animals; D001667:Binding, Competitive; D002038:Bungarotoxins / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008817:Mice, Mutant Strains; D009121:Muscle Denervation; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D009498:Neurotoxins / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000378:metabolism*; D012508:Sarcolemma / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D002038:Bungarotoxins; D009498:Neurotoxins; D011950:Receptors, Cholinergic; D000254:Sodium-Potassium-Exchanging ATPase