title: Demography predicts blood pressure response to once-daily enalapril monotherapy of mild to moderate essential hypertensive patients.
abstract: Enalapril was given once daily in low dose (5 to 10 mg) and high dose (20 to 40 mg) in 25 (15 white and 10 black) mild-to-moderate essential hypertensive patients. The white patients had a significant (p less than 0.005) supine diastolic blood pressure (SDBP) lowering with all doses of enalapril (from 97.2 +/- 1.8 to 85 +/- 2.4 mm Hg lowest). The black patient's SDBP did not decrease significantly (100.8 +/- 2.4 to 96.2 +/- 3.7 mm Hg lowest) with enalapril but addition of hydrochlorothiazide achieved satisfactory SDBP control. It is concluded that hydrochlorothiazide should be added if greater than 10 mg/day of enalapril is needed in white patients and the initial therapy in black patients should be a combination of enalapril and hydrochlorothiazide.
authors.affiliation: Department of Medicine, University of Louisville, School of Medicine, KY 40292.
authors.forename: G S
authors.initials: GS
authors.lastname: Thind
mesh_terms: D044383:Black People; D001794:Blood Pressure / Q000187:drug effects*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000008:administration & dosage* / Q000627:therapeutic use; D005544:Forecasting; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D011788:Quality of Life; D044465:White People
chemical_list: D006852:Hydrochlorothiazide; D004656:Enalapril