title: Clearance of polymeric IgA aggregates in humans.
abstract: Clearance of aggregated human secretory immunoglobulin A (AHS-IgA) was studied in nine patients affected by primary IgA nephropathy (IgAGN) and six normal volunteers from the medical staff. Samples of whole blood, erythrocytes, and serum were taken from 3 to 120 minutes after injection of 0.5 mg of 131iodine-labeled AHS-IgA. No significant radioactivity was recorded on erythrocytes. The clearance curve of AHS-IgA from the circulation, calculated by measuring trichloroacetic acid precipitable radioactivity in serum, was found to be biexponential with an initial fast component significantly prolonged in patients (mean half-time, 19.4 minutes, range, 14 to 26 minutes) compared with controls (mean, 12.2 minutes, range, 7.6 to 16.8 minutes; P less than 0.01). These data indicate that clearance of aggregated polymeric IgA does not involve the erythrocyte transport system and seems to be defective in IgAGN patients.
authors.affiliation: Divisione Nefrologia e Dialisi, Ospedale Nuova Astanteria Martini, Torino, Italia.
authors.forename: D
authors.initials: D
authors.lastname: Roccatello
authors.forename: G
authors.initials: G
authors.lastname: Picciotto
authors.forename: R
authors.initials: R
authors.lastname: Coppo
authors.forename: G
authors.initials: G
authors.lastname: Piccoli
authors.forename: A
authors.initials: A
authors.lastname: Molino
authors.forename: G
authors.initials: G
authors.lastname: Cacace
authors.forename: A
authors.initials: A
authors.lastname: Amore
authors.forename: A
authors.initials: A
authors.lastname: Amoroso
authors.forename: G
authors.initials: G
authors.lastname: Quattrocchio
authors.forename: L M
authors.initials: LM
authors.lastname: Sena
mesh_terms: D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000276:immunology; D001774:Blood Chemical Analysis; D006680:HLA Antigens / Q000032:analysis / Q000145:classification; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000378:metabolism* / Q000652:urine; D007674:Kidney Diseases / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D011108:Polymers; D012016:Reference Values
chemical_list: D000936:Antigen-Antibody Complex; D006680:HLA Antigens; D007071:Immunoglobulin A, Secretory; D011108:Polymers