Changes in benzodiazepine receptors in Alzheimer-type dementia.
We studied benzodiazepine receptors in brains obtained at autopsy from 7 normal controls and 7 patients with Alzheimer-type dementia, using 3H-flunitrazepam as a ligand. Compared with controls, 3H-flunitrazepam binding sites were significantly reduced in number in frontal and temporal cortex and hippocampus in the Alzheimer-type dementia brains. These results suggest that there are significant changes in the number of benzodiazepine receptors in selected brain regions of patients with Alzheimer-type dementia.
Shimohama
S
S
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
Taniguchi
T
T
Fujiwara
M
M
Kameyama
M
M
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005445:Flunitrazepam / Q000378:metabolism*; D006801:Humans; D011963:Receptors, GABA-A / Q000378:metabolism*
D011963:Receptors, GABA-A; D005445:Flunitrazepam