The use of indomethacin, sulindac, and tamoxifen for the treatment of desmoid tumors associated with familial polyposis.
Seven familial polyposis patients with desmoid tumors were treated with indomethacin, sulindac, or tamoxifen either as single agents or in combination. Serial computed tomographic (CT) scan examination was employed for objective measurement of tumor size since physical examination alone was an inaccurate means to evaluate intraabdominal and retroperitoneal desmoids. Only one patient with minimal tumor burden demonstrated a favorable response with complete resolution of an abdominal wall desmoid.
Klein
W A
WA
Department of Surgery, Memorial Sloan-Kettering Cancer Center, Cornell University Medical College, New York, NY 10021.
Miller
H H
HH
Anderson
M
M
DeCosse
J J
JJ
D011125:Adenomatous Polyposis Coli / Q000188:drug therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D005350:Fibroma / Q000188:drug therapy*; D006801:Humans; D007192:Indenes / Q000627:therapeutic use*; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D013467:Sulindac / Q000627:therapeutic use*; D013629:Tamoxifen / Q000627:therapeutic use*
D007192:Indenes; D013629:Tamoxifen; D013467:Sulindac; D007213:Indomethacin