title: Adverse haemodynamic effects of sodium bicarbonate in metabolic acidosis.
abstract: In a patient with viral pneumonia, acute respiratory and renal failure and metabolic acidosis, a reduction in left ventricular stroke work was observed on the three occasions that 100 ml of 8.4% sodium bicarbonate was infused. Blood pressure and cardiac output decreased on two of the occasions. Since intravenous sodium bicarbonate may produce adverse cardiovascular effects, a right heart catheter should be inserted to monitor these effects when alkali therapy is administered to an acutely ill patient with metabolic acidosis.
authors.affiliation: Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital South Australia.
authors.forename: D J
authors.initials: DJ
authors.lastname: Cooper
authors.forename: L I
authors.initials: LI
authors.lastname: Worthley
mesh_terms: D000138:Acidosis / Q000188:drug therapy* / Q000503:physiopathology; D058186:Acute Kidney Injury / Q000150:complications; D000368:Aged; D001639:Bicarbonates / Q000009:adverse effects*; D006333:Heart Failure / Q000139:chemically induced* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D011024:Pneumonia, Viral / Q000150:complications; D012964:Sodium / Q000009:adverse effects*; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D017693:Sodium Bicarbonate; D012964:Sodium