An endogenous ligand for phencyclidine receptors: isolated from human brains.
Using preparative HPLC, Sephadex G-25 and analytic HPLC, we obtained an active peak inhibiting (3H) PCP receptor binding, with a molecular weight of 3,000 daltons. Another isolation process included acetic acid extraction, Toyopearl HW gel filtration, Sephadex G-10 chromatography and analytic HPLC. An active peak was also observed, which was consistent with that from the first isolation process.
Lu
W X
WX
Shanghai Medical University, China.
Liu
Y F
YF
Zhu
Y X
YX
Xi
G L
GL
Zhang
A Z
AZ
D001921:Brain / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008970:Molecular Weight; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D017478:Receptors, Phencyclidine; D014020:Tissue Extracts / Q000378:metabolism
D008024:Ligands; D017981:Receptors, Neurotransmitter; D011957:Receptors, Opioid; D017478:Receptors, Phencyclidine; D014020:Tissue Extracts