Norfloxacin resistance in a clinical isolate of Escherichia coli.
Analysis of DNA gyrase supercoiling and of norfloxacin uptake in Escherichia coli GN14176, a moderately norfloxacin-resistant clinical isolate, indicated that resistance was associated with both an altered drug target and a reduction in drug uptake.
Aoyama
H
H
Episome Institute, Gunma, Japan.
Sato
K
K
Kato
T
T
Hirai
K
K
Mitsuhashi
S
S
D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000378:metabolism / Q000494:pharmacology*; D014552:Urinary Tract Infections / Q000382:microbiology
D004250:DNA Topoisomerases, Type II; D009643:Norfloxacin