title: Effect of high temperature on Aedes albopictus cells infected with Mayaro virus.
abstract: The multiplication of Mayaro virus in Aedes albopictus cells was drastically inhibited after incubation at 37 degrees C. The effect of short-term exposure of infected cells to high temperatures (heat shock) produced a preferential translation of the heat shock messengers when compared to the viral mRNAs. When cells were shifted back to 28 degrees C (the optimum growth temperature for Aedes albopictus cells), preferential translation of viral mRNA occurred. Although the infected cells were programmed for preferential translation of viral messengers, the thermal treatment was able to shift the translational machinery towards synthesis of heat shock proteins.
authors.affiliation: Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brasil.
authors.forename: M G
authors.initials: MG
authors.lastname: Carvalho
authors.forename: M A
authors.initials: MA
authors.lastname: Rebello
authors.forename: J M
authors.initials: JM
authors.lastname: Mezencio
mesh_terms: D000330:Aedes / Q000382:microbiology*; D000524:Alphavirus / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002999:Clone Cells / Q000382:microbiology; D005786:Gene Expression Regulation; D006358:Hot Temperature; D014176:Protein Biosynthesis; D012367:RNA, Viral; D014779:Virus Replication
chemical_list: D012367:RNA, Viral