title: [Promoting effect of the Chinese medicinal herb, wikstroemia chamaedaphne and tung oil extracts on carcinoma of the uterine cervix induced by HSV-2 or methylcholanthrene (MCA) in mice].
abstract: The promoting effect of the Chinese medicinal herb, Wikstroemia chamaedaphne and Tung oil extracts (WC and HHPA) on carcinoma of uterine cervix induced by HSV-2 or MCA in mice was studied. The results showed that WC and HHPA extracts were not carcinogenic themselves. After carcinogen HSV-2 and MCA treatment, WC and HHPA were added separately. The inducing rates by HSV-2 increased from 7.4% to 21.1% and 26.3%, those by MCA increased from 56.5% to 82.8% and 84.4%. There was a significant difference between the combined groups and groups with HSV-2 or MCA only. The experimental results suggest that these two kinds of extracts play a promoting effect on carcinogenesis. The relation between the carcinogenesis of uterine cervix or nasopharynx and WC or HHPA extracts is discussed.
authors.affiliation: Institute of Virology, Hubei Medical College, Wuhan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: M H
authors.initials: MH
authors.lastname: Chen
authors.forename: Y X
authors.initials: YX
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Xiao
authors.forename: H Y
authors.initials: HY
authors.lastname: Liu
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced*; D003043:Cocarcinogenesis; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005260:Female; D008748:Methylcholanthrene; D051379:Mice; D010703:Phorbol Esters / Q000009:adverse effects*; D018139:Simplexvirus; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced*
chemical_list: D004365:Drugs, Chinese Herbal; D010703:Phorbol Esters; C028113:croton factor F1; D008748:Methylcholanthrene