The effects of three beta-lactamase inhibitors: YTR830H, sulbactam and clavulanic acid on the growth of human cells in culture.
Three beta-lactamase inhibitors: YTR83OH (YTR), sulbactam and clavulanic acid were studied for their effects on the growth of human amnion FL line cells. The numbers of viable cells after the 3-day culture were almost unaffected by YTR at concentrations up to 250 mg/l. The effects of sulbactam on FL cells were similar to those of YTR. The growth inhibitory effects of clavulanic acid were significantly different and were effective down to a concentration of 50 mg/l. The morphological effects were also observed microscopically.
Yamabe
S
S
Kobe College Research Institute, Nishinomiya, Japan.
Adachi
K
K
Watanabe
M
M
Ueda
S
S
D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000633:toxicity*; D006801:Humans; D010397:Penicillanic Acid / Q000633:toxicity*; D013407:Sulbactam / Q000633:toxicity*; D000078142:Tazobactam; D065093:beta-Lactamase Inhibitors
D002969:Clavulanic Acids; D065093:beta-Lactamase Inhibitors; D019818:Clavulanic Acid; D010397:Penicillanic Acid; D013407:Sulbactam; D000078142:Tazobactam