title: [Nyctohemeral variations of cyclosporine administered orally in renal transplant patients].
abstract: The circadian intraindividual variations of cyclosporin blood concentrations were studied in nine renal transplant patients at steady state. The cyclosporin was administrated orally twice a day (9 a.m. and 21 p.m.). Blood concentrations were analysed by H.P.L.C. AUC = area under the drug concentration versus time curve, Cmax = maximum blood concentration, Cmin = minimum blood concentration, Tmax = Time to maximum concentration. Statistical analysis (t, Wilcoxon) shows: AUC, Cmax and Tmax are not significantly modified, Cmin (21) less than Cmin (9) (p less than 0.02). This phenomenon seems to be rather a cyclosporin metabolism variation than an absorption alteration.
authors.forename: M
authors.initials: M
authors.lastname: Ramon
authors.forename: D
authors.initials: D
authors.lastname: Morel
authors.forename: F
authors.initials: F
authors.lastname: Penouil
authors.forename: J
authors.initials: J
authors.lastname: Grellet
authors.forename: L
authors.initials: L
authors.lastname: Potaux
authors.forename: M C
authors.initials: MC
authors.lastname: Saux
authors.forename: A
authors.initials: A
authors.lastname: Brachet-Liermain
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002940:Circadian Rhythm; D003524:Cyclosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged
chemical_list: D003524:Cyclosporins
vernacular_title: Variations nycthémérales de la ciclosporine administrée par voie orale à des transplantés rénaux.