T cells are required for coxsackievirus B1 induced murine polymyositis.
Murine polymyositis (PM) induced by coxsackievirus B1 (CVB1) has been used as a model of human PM. Our study was undertaken to investigate the role of T cells in CVB1 induced PM by examining disease development in neonatally thymectomized mice. Clinical weakness and histological inflammatory myositis occurred in 42.7% of sham operated animals but only 7.7% of thymectomized mice. These experiments demonstrate the importance of T cells in the pathogenesis of this virus induced autoimmune disorder.
Ytterberg
S R
SR
Department of Medicine, Minneapolis Veterans Administration Medical Center, MN 55417.
Mahowald
M L
ML
Messner
R P
RP
D000818:Animals; D003384:Coxsackievirus Infections; D004198:Disease Susceptibility; D029822:Enterovirus B, Human; D008214:Lymphocytes / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D009132:Muscles / Q000473:pathology / Q000503:physiopathology; D009220:Myositis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D009336:Necrosis; D013934:Thymectomy