[Effect of activation and blocking of the GABA-ergic system during disorders of memory trace reproduction].
Analysis of the effects of activation and blocade of GABA-ergic system showed significant changes in the level of reproduction of conditioned reaction of passive avoidance in mice--lowering under administration of muscimol and baclopfen and increase under administration of picrotoxin and bicucullin in a dose of 1 mg/kg. Sharp lowering was observed of the efficiency of activating influence of drugs depressing the activity of GABA-ergic system at a long interval from the moment of administration of "psychogenic" amnestic agent. Dependence was established of the drugs influence on the type of memory disturbance: higher value of bicucullin and picrotoxin in retrieval of memory trace disturbed by cycloheximide in comparison to "psychogenic" amnesia. On the basis of the obtained results a suggestion is made on the significance of GABA-ergic mechanisms in regulation of reproduction processes.
Dubrovina
N I
NI
Il'iuchenok
R Iu
RIu
D000647:Amnesia / Q000503:physiopathology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001640:Bicuculline / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010852:Picrotoxin / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology
D001640:Bicuculline; D010852:Picrotoxin; D011963:Receptors, GABA-A
Effekt aktivatsii i blokady GAMKergicheskoĭ sistemy pri narushenii vosproizvedeniia sleda pamiati.