title: Synthesis and characterization of potential tumor scintigraphic agents.
abstract: Potential tumor imaging radiopharmaceutical agents have been prepared by attaching a cisplatin derivative to a ligand capable of forming a stable complex with 99mTc. Three new organometallic compounds, with iminodiacetic acid as the 99mTc chelating group and 2,3-diaminopropionamide as the platinum complexing group, have been prepared and characterized. Preliminary biodistribution studies in tumor bearing mice support the utility of this approach.
authors.affiliation: Isotope Division, Prime Minister's Department, Bangi, Malaysia.
authors.forename: A B
authors.initials: AB
authors.lastname: Awaluddin
authors.forename: J J
authors.initials: JJ
authors.lastname: Jacobs
authors.forename: D W
authors.initials: DW
authors.lastname: Bourne
authors.forename: D J
authors.initials: DJ
authors.lastname: Maddalena
authors.forename: J G
authors.initials: JG
authors.lastname: Wilson
authors.forename: R E
authors.initials: RE
authors.lastname: Boyd
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D007202:Indicators and Reagents; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000000981:diagnostic imaging*; D012516:Osteosarcoma / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013329:Structure-Activity Relationship; D013667:Technetium; D014018:Tissue Distribution
chemical_list: D007202:Indicators and Reagents; D013667:Technetium