Comparison of radiation-induced chromosomal damage between normal individuals and patients with familial polyposis coli.
Cultured leukocytes of peripheral blood obtained from normal, healthy individuals and from patients with familial polyposis coli (FP) were exposed to 0 rads or 300 rads of 137Cs gamma radiation at G0 to compare damage in these two groups. Only cells in the first mitotic division were considered. The average chromosomal damage in the FP patients was not significantly higher than that in the normal group. The induced chromosomal damage at G0 was normally distributed in both the control and the patient groups as well as when they were combined.
Kakati
S
S
Department of Genetics and Endocrinology, Roswell Park Memorial Institute, Buffalo, NY 14263.
Herrera
L
L
Drury
R E
RE
Sandberg
A A
AA
D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D000328:Adult; D002586:Cesium; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D006801:Humans; D007962:Leukocytes / Q000528:radiation effects; D008875:Middle Aged
D002586:Cesium