Serological and structural comparison of immunodeficiency viruses from man, African green monkey, rhesus monkey and sooty mangabey.
We have studied the serological relationship among the human immunodeficiency virus type 1 (HIV-1), and three simian immunodeficiency viruses (SIV). SIVagm was isolated from African green monkeys (Cercopithecus aethiops), and compared with the previously described isolates of SIVmac from a rhesus macaque (Macaca mulatta) and SIVsm from a sooty mangabey (Cercocebus atys). With respect to the glycoproteins, the simian viruses represent a subgroup apparently different from HIV. To classify HIV and SIV isolates further, we compared tryptic peptide maps of the core polypeptides p 18 and p 24 of HIV-2, three HIV-1 and five SIV isolates. Each peptide map was distinguishable, and differences are most prominent between the HIV-1 group and the SIVmac/SIVsm group. HIV-2 is very similar to SIVmac and SIVsm. The three SIVagm isolates form a more heterogeneous group. The p24s of all SIVagms are more similar to the p24s of HIV-1, but with respect to p 18, one isolate is similar to HIV-1, while the two others are more related to SIVmac, SIVsm, and HIV-2.
Jurkiewicz
E
E
Deutsches Primaten-Zentrum, Göttingen, Bundesrepublik Deutschland.
Hunsmann
G
G
Hayami
M
M
Ohta
Y
Y
Schmitz
H
H
Schneider
J
J
D002520:Cercopithecidae / Q000382:microbiology*; D002521:Cercopithecus / Q000382:microbiology*; D002522:Chlorocebus aethiops / Q000382:microbiology*; D003429:Cross Reactions; D017977:Deltaretrovirus / Q000276:immunology / Q000302:isolation & purification*; D006678:HIV / Q000276:immunology / Q000302:isolation & purification*; D000882:Haplorhini / Q000382:microbiology*; D006801:Humans; D008251:Macaca / Q000382:microbiology*; D008253:Macaca mulatta / Q000382:microbiology*; D012703:Serotyping; D013045:Species Specificity