title: BoLA antigens are associated with increased frequency of persistent lymphocytosis in bovine leukaemia virus infected cattle and with increased incidence of antibodies to bovine leukaemia virus.
abstract: The association between bovine major histocompatibility system (BoLA) type and persistent lymphocytosis in cattle with antibodies to bovine leukaemia virus was examined by comparing antigen frequencies in cattle with persistent lymphocytosis to controls matched for age, sex, breed and presence of antibodies to BLV. The cattle came from nine dairy herds in south-east Queensland, Australia; six herds were Australian Illawarra Shorthorn (AIS), two herds were Jersey and one herd was Friesian. Antigen W6 and Eu28R were more common in cattle with persistent lymphocytosis than in controls. Antigen W8 was less common in AIS cattle with persistent lymphocytosis. A study of 24 offspring from one sire, heterozygous for W10 and Eu28R, showed that offspring inheriting Eu28R from the sire were significantly more likely to have antibodies to BLV than offspring inheriting the opposing W10 haplotype.
authors.affiliation: Department of Immunology, John Curtin School of Medical Research, Australian National University, ACT.
authors.forename: M J
authors.initials: MJ
authors.lastname: Stear
authors.forename: C K
authors.initials: CK
authors.lastname: Dimmock
authors.forename: M J
authors.initials: MJ
authors.lastname: Newman
authors.forename: F W
authors.initials: FW
authors.lastname: Nicholas
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000235:genetics; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics / Q000276:immunology*; D006239:Haplotypes; D006649:Histocompatibility Antigens / Q000145:classification / Q000235:genetics*; D007938:Leukemia / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D001909:Leukemia Virus, Bovine / Q000276:immunology; D008218:Lymphocytosis / Q000235:genetics / Q000276:immunology / Q000662:veterinary
chemical_list: D000914:Antibodies, Viral; D006649:Histocompatibility Antigens