HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes.
The human T-cell leukemia virus (HTLV) types I and II have two nonstructural genes that are encoded in overlapping reading frames. One of these genes, known as tax, has been shown to encode a protein responsible for enhanced transcription (transactivation) from the viral long terminal repeats (LTRs). Genetic evidence indicates that the second nonstructural gene of HTLV-II, here designated rex, acts in trans to modulate tax gene-mediated transactivation in a concentration-dependent fashion. The rex gene may regulate the process of transactivation during the viral life cycle.
Rosenblatt
J D
JD
Department of Medicine, UCLA School of Medicine.
Cann
A J
AJ
Slamon
D J
DJ
Smalberg
I S
IS
Shah
N P
NP
Fujii
J
J
Wachsman
W
W
Chen
I S
IS
D001483:Base Sequence; D004274:DNA, Recombinant; D004279:DNA, Viral / Q000235:genetics; D017977:Deltaretrovirus / Q000235:genetics*; D005809:Genes, Regulator; D005814:Genes, Viral; D009154:Mutation; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D013539:Simian virus 40 / Q000235:genetics; D014158:Transcription, Genetic; D014162:Transfection
D004274:DNA, Recombinant; D004279:DNA, Viral; D012333:RNA, Messenger; D012367:RNA, Viral