[Structural stabilization of lipids and visual pigment rhodopsin in the photoreceptor membrane by vitamin E].
Interaction of alpha-tocopherol with free fatty acids in bovine retinal photoreceptor membranes was studied using ESR spin-probe technique and measurements of rhodopsin thermal denaturation rates. Exogenous alpha-tocopherol incorporated into photoreceptor membranes prevented thermal destabilization of rhodopsin caused by free fatty acids. The efficiency of the stabilizing action of alpha-tocopherol directly depended both on the chain length and the degree of fatty acid unsaturation.
Tiurin
V A
VA
Korol'kov
S N
SN
Berman
A L
AL
Kagan
V E
VE
D000818:Animals; D002417:Cattle; D004347:Drug Interactions; D004578:Electron Spin Resonance Spectroscopy; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D008563:Membrane Lipids / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D010786:Photoreceptor Cells / Q000187:drug effects* / Q000378:metabolism; D012168:Retinal Pigments / Q000378:metabolism*; D012243:Rhodopsin / Q000378:metabolism*; D013113:Spin Labels; D014810:Vitamin E / Q000494:pharmacology*
D005230:Fatty Acids, Nonesterified; D008563:Membrane Lipids; D010743:Phospholipids; D012168:Retinal Pigments; D013113:Spin Labels; D014810:Vitamin E; D012243:Rhodopsin
Strukturnaia stabilizatsiia lipidov i zritel'nogo pigmenta rodopsina v fotoretseptornoĭ membrane vitaminom E.