Epstein-Barr virus related lymphoepithelioma-like carcinoma of lung.
A malignant neoplasm localized to the lung is reported in a rather unusual host: a 40-year-old female, nonsmoker, of South-East Asiatic origin. The histology was of nasopharyngeal-like carcinoma character and ultrastructural examination confirmed a diagnosis of nonkeratinizing, poorly differentiated squamous cell carcinoma. The clinicopathologic findings were more suggestive of a primary pulmonary origin than the manifestation of an occult nasopharyngeal primary. The immunological profile was highly suggestive of an Epstein-Barr virus (EBV) associated epithelial neoplasia. This case might widen the spectrum of EBV-associated neoplasia, by inclusion of lower respiratory tract as a target organ.
Bégin
L R
LR
Department of Pathology, McGill University, Montreal, Quebec, Canada.
Eskandari
J
J
Joncas
J
J
Panasci
L
L
D000328:Adult; D002051:Burkitt Lymphoma / Q000150:complications*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology* / Q000503:physiopathology