Lower number of atrial natriuretic peptide receptors in thymocytes and spleen cells of spontaneously hypertensive rats.
Spontaneously hypertensive rats (SHR) have a much lower number of atrial natriuretic peptide (ANP) receptors in thymus and spleen from young and adult animals than age-matched normotensive controls. In spite of this low receptor concentration, the ANP-stimulated cyclic GMP response in isolated thymocytes and spleen cells from SHR was similar to that of normotensive control rats. Alterations in ANP receptor concentration in thymus and spleen of SHR may be related to the immune abnormalities described in these animals, and to the pathophysiology of genetic hypertension.
Kurihara
M
M
Unit on Preclinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892.
Castrén
E
E
Gutkind
J S
JS
Saavedra
J M
JM
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism / Q000494:pharmacology; D006152:Cyclic GMP / Q000096:biosynthesis; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism*; D011919:Rats, Inbred Strains / Q000378:metabolism*; D011921:Rats, Inbred WKY; D017461:Receptors, Atrial Natriuretic Factor; D011956:Receptors, Cell Surface / Q000032:analysis* / Q000172:deficiency; D013154:Spleen / Q000032:analysis* / Q000166:cytology; D013268:Stimulation, Chemical; D013950:Thymus Gland / Q000032:analysis* / Q000166:cytology
D011956:Receptors, Cell Surface; D009320:Atrial Natriuretic Factor; D017461:Receptors, Atrial Natriuretic Factor; D006152:Cyclic GMP