[Droperidol, seduxen, fentanyl: a study of immune reactions in vitro].
Clinical concentration of droperidol, seduxen, fentanyl were studied for their effects on in vitro immunity reaction with lymphocytes from donors and patients with lung carcinoma. In the donors, the agents caused no changes in E- and EAC-rosette formation. In the patients with lung carcinoma, droperidol elevated the number of theophylline-sensitive T lymphocytes, lowered theophylline-resistant ones and eventually normalized a theophylline-resistant to theophylline-sensitive T cell ratio. Fentanyl, 5 ng/ml was demonstrated to increase amounts of early T lymphocytes. Fentanyl concentrations (5 and 25 ng/ml) decreased B lymphocytes. It was concluded that droperidol produced a positive action and fentanyl showed heterogeneous effects on E- and EAC-rosette formation in patients with lung carcinoma.
Gadalov
V P
VP
Filatov
P P
PP
Medvedev
V N
VN
Malik
S S
SS
D000328:Adult; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D003975:Diazepam / Q000494:pharmacology*; D004329:Droperidol / Q000494:pharmacology*; D005260:Female; D005283:Fentanyl / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007958:Leukocyte Count / Q000187:drug effects; D008175:Lung Neoplasms / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D004329:Droperidol; D003975:Diazepam; D005283:Fentanyl
Droperidol, seduksen, fentanil: izuchenie reaktsiĭ immuniteta in vitro.