title: Combined short- and long-term therapy for the treatment of cytomegalovirus retinitis using ganciclovir (BW B759U).
abstract: A total of 66 eyes in 41 patients were treated for cytomegalovirus (CMV) retinitis with a new acyclic nucleoside, ganciclovir (BW B759U). At the completion of the short-term therapy period of 21 days, 87.7% of eyes had stabilized or improved. Seventy-two percent of eyes stabilized or improved during long-term home maintenance therapy. Leukopenia and increased liver function abnormalities were the most common adverse drug reactions seen in this series. Ganciclovir dramatically improved the quality of life in these patients, but clinical evidence suggests that it is a virostatic medication requiring indefinite long-term maintenance therapy.
authors.affiliation: Department of Ophthalmology, Beth Israel Medical Center, New York, NY 10003.
authors.forename: J
authors.initials: J
authors.lastname: Orellana
authors.forename: S A
authors.initials: SA
authors.lastname: Teich
authors.forename: A H
authors.initials: AH
authors.lastname: Friedman
authors.forename: F
authors.initials: F
authors.lastname: Lerebours
authors.forename: J
authors.initials: J
authors.lastname: Winterkorn
authors.forename: D
authors.initials: D
authors.lastname: Mildvan
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000212:Acyclovir / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism; D003586:Cytomegalovirus Infections; D005260:Female; D015774:Ganciclovir; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D012173:Retinitis / Q000150:complications / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D013997:Time Factors
chemical_list: D000469:Alkaline Phosphatase; D015774:Ganciclovir; D000212:Acyclovir