title: [After care of differentiated thyroid gland carcinoma with special reference to serum thyroglobulin level].
abstract: The histories of 358 patients with carcinomas of the thyroid have been evaluated. Differentiated carcinomas of the thyroid (84.6%) were treated by means of thyroidectomy, ablative radio-iodine therapy (tissue dose 1000 Gray), TSH-suppressive thyroid hormone medication and, in special cases, external radiation. Even differentiated carcinomas showed a high recurrence rate. Metastases occurred particularly in the lungs, the skeleton and locally; low iodine uptake, particularly in distant metastases from papillary carcinomas, often made it impossible to reach a diagnosis by using radio-iodine. Some pulmonary metastases could only be demonstrated radiologically and some skeletal metastases could be shown radiologically or scintigraphically. A modified follow-up program for differentiated carcinomas is suggested, based on the highly sensitive and specific thyroglobulin determination under TSH suppression (sensitivity 97.9%, specificity 93.6%).
authors.affiliation: Krankenhausweckverband Augsburg.
authors.forename: W
authors.initials: W
authors.lastname: Kanitz
authors.forename: I G
authors.initials: IG
authors.lastname: Böttger
authors.forename: H W
authors.initials: HW
authors.lastname: Pabst
authors.forename: P
authors.initials: P
authors.lastname: Heidenreich
authors.forename: W
authors.initials: W
authors.lastname: Dirr
mesh_terms: D002277:Carcinoma / Q000097:blood / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D011863:Radioimmunoassay; D011879:Radiotherapy Dosage; D013954:Thyroglobulin / Q000097:blood*; D013963:Thyroid Hormones / Q000627:therapeutic use; D013964:Thyroid Neoplasms / Q000097:blood / Q000628:therapy*; D013965:Thyroidectomy
chemical_list: D007457:Iodine Radioisotopes; D013963:Thyroid Hormones; D013954:Thyroglobulin
vernacular_title: Nachsorge des differenzierten Schilddrüsenkarzinoms unter spezieller Berücksichtigung des Serum-Thyreoglobulin-(hTg-)Spiegels.