Possible involvement of interferon alfa in the pathogenesis of fever in systemic lupus erythematosus.
Serum concentrations of interferon alfa, interleukin 1, and tumour necrosis factor alpha were measured in 25 untreated patients with systemic lupus erythematosus (SLE). A close correlation was found between serum concentrations of interferon alfa and the degree of fever, while no significant correlations were found between fever and interleukin 1 or tumour necrosis factor alpha. These results suggest the possible involvement of interferon alfa in the pathogenesis of fever in SLE.
Kanayama
Y
Y
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Kim
T
T
Inariba
H
H
Negoro
N
N
Okamura
M
M
Takeda
T
T
Inoue
T
T
D005334:Fever / Q000097:blood / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007370:Interferon Type I / Q000097:blood / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*
D007370:Interferon Type I