[Participation of the peptidergic and endogenous opiate systems in the pathogenesis of early manifestations of the alcohol abstinence syndrome].
TRH and naloxone influence on the clinical hormonal manifestations of the alcohol withdrawal syndrome (AWS) was studied. The results obtained were suggestive of the association of the pathogenesis of symptoms like frustration, skin hyperemia, tachycardia, and raised BP with function of the peptidergic system. It should be noted that symptoms like depression, sleep disturbances and headaches happened to be more sensitive to TRH while sweating is more sensitive to naloxone. A positive therapeutic effect of naloxone in the early period of AWS was likely to result from lowered function of the opiate system. The data obtained led to a preliminary conclusion of a close interrelationship and involvement of the hormonal, peptidergic and opiate systems in AWS pathogenesis, this being an important factor for the understanding of alcohol-induced abnormalities and for the choice of pathogenetically founded therapeutic methods.
Kokhanenko
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D000328:Adult; D000431:Ethanol / Q000009:adverse effects*; D006728:Hormones / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology; D009479:Neuropeptides / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000187:drug effects* / Q000502:physiology; D011957:Receptors, Opioid / Q000187:drug effects* / Q000502:physiology; D013375:Substance Withdrawal Syndrome / Q000097:blood / Q000209:etiology*; D013695:Temperance; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D013997:Time Factors
D006728:Hormones; D009479:Neuropeptides; D017981:Receptors, Neurotransmitter; D011957:Receptors, Opioid; D009270:Naloxone; D000431:Ethanol; D013973:Thyrotropin-Releasing Hormone
Izuchenie uchastiia peptidergicheskoĭ i éndogennoĭ opiatnoĭ sistem v patogeneze rannikh proiavleniĭ alkogol'nogo abstinentnogo sindroma.