Direct determination of urinary pseudouridine by high-performance liquid chromatography.
A reversed-phase high-performance liquid chromatographic method was developed for the determination of pseudouridine in urine. This method does not need pretreatment by boronate affinity gel. Therefore, it can be used in screening patients with malignant disease and for monitoring clinical response to chemotherapy with other tumor markers.
Yamamoto
T
T
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
Higashino
K
K
Tamura
S
S
Fujioka
H
H
Amuro
Y
Y
Hada
T
T
D014408:Biomarkers, Tumor / Q000652:urine; D002277:Carcinoma / Q000652:urine; D006528:Carcinoma, Hepatocellular / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000652:urine; D006801:Humans; D008113:Liver Neoplasms; D008991:Monitoring, Physiologic; D011560:Pseudouridine / Q000652:urine*; D014529:Uridine / Q000031:analogs & derivatives*
D014408:Biomarkers, Tumor; D011560:Pseudouridine; D003404:Creatinine; D014529:Uridine