Effect of amphotericin B and tear K+ on PD responses to changes in stromal K+ in frog cornea.
Data have been presented in this paper that support the hypothesis that normal or anomalous responses to changes in stromal K+ are a result of the relative conductances of the simple K+ and the (Na+ + K+)-ATPase pathways located in the basolateral membrane of the corneal epithelium. The simple K+ conductance may be changed by changing the tear K+ concentration in the presence of amphotericin B and by the use of Ba2+ in the stromal solution.
Carrasquer
G
G
Department of Medicine, University of Louisville, Kentucky.
Luo
R
R
Rehm
W S
WS
Schwartz
M
M
Dinno
M
M
D000666:Amphotericin B / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001464:Barium / Q000494:pharmacology; D003315:Cornea / Q000187:drug effects / Q000378:metabolism*; D004553:Electric Conductivity; D007700:Kinetics; D011188:Potassium / Q000378:metabolism*; D011892:Rana catesbeiana; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013666:Tears / Q000378:metabolism*
D001464:Barium; D000666:Amphotericin B; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium