Effect of sodium depletion on pressor responsiveness in ACTH-induced hypertension in man.
1. Pressor responsiveness to angiotensin II (AII) and phenylephrine (PHE) was measured before and after 5 days of ACTH (1 mg i.m. daily) in six normal men maintained on low sodium diet (15 mmol daily). 2. ACTH caused a significant increase in systolic blood pressure of 9 mmHg. 3. There was no change in pressor responsiveness to AII with ACTH. 4. ACTH increased pressor responsiveness to PHE for both systolic and diastolic blood pressure, with a fall in the threshold for response from 0.9 to 0.6 micrograms/kg per min. 5. Increased pressor sensitivity to catecholamines during ACTH administration in man is not sodium-dependent.
Connell
J M
JM
MRC Blood Pressure Unit, Western Infirmary, Glasgow, Scotland.
Fisher
B M
BM
Davidson
G
G
Fraser
R
R
Whitworth
J A
JA
D000324:Adrenocorticotropic Hormone / Q000009:adverse effects*; D000328:Adult; D000804:Angiotensin II / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D004039:Diet, Sodium-Restricted; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D007262:Infusions, Intravenous; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology
D000804:Angiotensin II; D010656:Phenylephrine; D000324:Adrenocorticotropic Hormone