[Metabolic changes in the peritoneal macrophages of mice differing in the H-2 locus of histocompatibility after intraperitoneal administration of salmozan].
The activity of 5'-nucleotidase in mouse peritoneal macrophages differing by histocompatibility locus H-2 after intraperitoneal injection of salmozan, an immunostimulating agent, has been studied. The character of changes in the activity of 5'-nucleotidase in peritoneal exudate macrophages after the intraperitoneal injection of salmozan has proved to be unrelated to the genotype of mice. The injection of salmozan induces a deep and prolonged decrease in the activity of 5'-nucleotidase in these macrophages. In mice of different strains changes in the activity of 5'-nucleotidase after the intraperitoneal injection of salmozan are of a linear type and can be approximated by a linear regression model.
Tumanian
M A
MA
Kirillicheva
G B
GB
Ermolova
E V
EV
D015720:5'-Nucleotidase; D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D005838:Genotype; D006183:H-2 Antigens / Q000276:immunology*; D007274:Injections, Intraperitoneal; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009708:Nucleotidases / Q000378:metabolism; D010529:Peritoneal Cavity / Q000166:cytology; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage*
D000276:Adjuvants, Immunologic; D006183:H-2 Antigens; D011135:Polysaccharides, Bacterial; C029023:salmozan; D009708:Nucleotidases; D015720:5'-Nucleotidase
Izuchenie metabolicheskikh izmeneniĭ v peritoneal'nykh makrofagakh mysheĭ, razlichaiushchikhsia po H-2-lokusu gistosovmestimosti, pri vnutribriushinnom vvedenii sal'mozana.