The effect of nedocromil sodium, sodium cromoglycate and codeine phosphate on citric acid-induced cough in dogs.
1. The effects of nedocromil sodium, sodium cromoglycate and codeine phosphate on citric acid-induced cough have been studied in conscious tracheostomised dogs. 2. Nedocromil sodium (approximately 15 mg given as an aerosol) and codeine phosphate (5 mg kg-1, i.v.) significantly increased the time to the first cough when dogs were challenged with citric acid aerosol. The mean number of coughs in the initial period of coughing fell after treatment of dogs with nedocromil sodium or with codeine phosphate, but this reduction in mean cough number was not statistically significant. 3. Neither sodium cromoglycate (approximately 15 mg given as an aerosol) nor saline had significant effect on a citric acid challenge. 4. It is concluded that nedocromil sodium, but not sodium cromoglycate, possesses an anti-tussive action that may result from inhibition of sensory nerve activity in the lung. Nedocromil sodium may prove useful in the treatment of unproductive cough in situations where the use of a centrally-acting antitussive is undesirable.
Jackson
D M
DM
Fisons plc-Pharmaceutical Division, Research and Development Laboratories, Loughborough, Leicestershire.
D000818:Animals; D000996:Antitussive Agents / Q000627:therapeutic use*; D002951:Citrates; D019343:Citric Acid; D003061:Codeine / Q000627:therapeutic use; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy*; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D004285:Dogs; D005260:Female; D008297:Male; D017835:Nedocromil; D011804:Quinolines / Q000627:therapeutic use*
D000996:Antitussive Agents; D002951:Citrates; D011804:Quinolines; D017835:Nedocromil; D019343:Citric Acid; D004205:Cromolyn Sodium; D003061:Codeine