Role of calcium in electron-acupuncture analgesia and the developments of analgesic tolerance to electro-acupuncture and morphine.
Role of brain Ca2+ in electro-acupuncture analgesia and the development of analgesic tolerance to electro-acupuncture and morphine were studied. At the same time, the inhibition by protein synthesis inhibitors of the development of analgesic tolerance to electro-acupuncture was observed. The results showed that like morphine tolerance, the brain Ca2+ and cAMP levels in mice were enhanced with the development of analgesic tolerance to electro-acupuncture. After treatment with protein synthesis inhibitors anisomycin, actinomycin or cycloheximide the development of analgesic tolerance to electro-acupuncture was inhibited, and concurrently, the brain Ca2+ and cAMP levels in the animals greatly reduced. From the changes of brain Ca2+ and cAMP levels, the analgesic effects by electro-acupuncture, morphine and lanthanides seem to be very similar and share a mutual ion basis and the mechanism of action. So does the development of analgesic tolerance to electro-acupuncture and morphine. These findings also suggest that the inhibition induced by the inhibitors of the analgesic tolerance to electro-acupuncture and morphine may be related to synthesis of new peptides or RNA in brain.
Zhang
Z X
ZX
Division of Physiology, Department of Biology, Nanjing Unviversity.
Zhang
Y Z
YZ
Jia
S P
SP
Lu
X J
XJ
Yu
R R
RR
Wang
X G
XG
Chen
R S
RS
D015670:Acupuncture Therapy; D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism* / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism; D004361:Drug Tolerance; D004599:Electric Stimulation Therapy; D005260:Female; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D004561:Transcutaneous Electric Nerve Stimulation
D000841:Anisomycin; D009020:Morphine; D000242:Cyclic AMP; D002118:Calcium