Prostaglandylinositol cyclic phosphate, an antagonist to cyclic AMP.
The existence of a low molecular weight intracellular regulator has been demonstrated. It is composed of PGE, myoinositol, and one phosphate and has been named cyclic PIP. Its synthesis is stimulated by hormones such as insulin in a dose-dependent manner, it is therefore suggested that cyclic PIP is a second messenger equivalent to cyclic AMP in its potency but antagonistic in its action.
Wasner
H K
HK
Diabetes-Forschungsinstitut, Düsseldorf, Federal Republic of Germany.
Salge
U
U
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D000242:Cyclic AMP / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D007294:Inositol / Q000378:metabolism; D007295:Inositol Phosphates / Q000302:isolation & purification / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D011458:Prostaglandins E / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D013403:Sugar Phosphates / Q000378:metabolism*; D014018:Tissue Distribution
D007295:Inositol Phosphates; D007328:Insulin; D011458:Prostaglandins E; D013403:Sugar Phosphates; C052775:prostaglandin-inositol cyclic phosphate; D007294:Inositol; D000242:Cyclic AMP