In vivo EDRF activity influences platelet function.
The administration of carbachol to rabbits to stimulate the release of endothelium derived relaxing factor (EDRF) results in inhibition of platelet aggregation and elevation of platelet cyclic GMP content. These effects are reversed by simultaneous administration of the EDRF inhibitors methylene blue or haemoglobin. The data provide the first direct biochemical evidence of in vivo EDRF activity.
Hogan
J C
JC
Department of Pharmacology and Thereapeutics, University of Wales College of Medicine, Heath Park, Cardiff.
Lewis
M J
MJ
Henderson
A H
AH
D000818:Animals; D001685:Biological Factors / Q000494:pharmacology*; D006152:Cyclic GMP / Q000097:blood; D066298:In Vitro Techniques; D009569:Nitric Oxide; D009599:Nitroprusside / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits
D001685:Biological Factors; D009599:Nitroprusside; D009569:Nitric Oxide; D006152:Cyclic GMP