title: Influence of the granulation technique and starting material properties on the lubricating effect of granular magnesium stearate.
abstract: Magnesium stearate has been granulated in four ways to produce lubricant granulations with different properties. The lubricating properties, as well as the tablet properties with the granulated lubricant, were evaluated on tablets prepared from a mixture of dicalcium phosphate, corn starch and microcrystalline cellulose. The lubricating effect of the magnesium stearate granulations showed a similar pattern regardless of the granulation technique used except for a granulation with providone. Increasing the particle size of the magnesium stearate granulation increased the amount of lubricant required to obtain lubrication similar to powdered magnesium stearate. Variations in the specific surface area of the starting materials could be masked by using them in granular form.
authors.forename: M E
authors.initials: ME
authors.lastname: Johansson
mesh_terms: D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D005079:Excipients; D008153:Lubrication; D011208:Powders; D012995:Solubility; D013229:Stearic Acids; D013607:Tablets; D013718:Tensile Strength
chemical_list: D005079:Excipients; D011208:Powders; D013229:Stearic Acids; D013607:Tablets; C031183:stearic acid