Prevention of epinephrine-induced hypokalemia by nonselective beta blockers.
Experimental evidence is presented that activation of beta 2 adrenoreceptors causes a dose-dependent decrease in plasma potassium, probably by shifting potassium into the cell. By this mechanism epinephrine may cause hypokalemia and predispose to cardiac arrhythmias. Prevention of these effects by nonselective beta blockers may contribute to the cardioprotective action of these drugs.
Vincent
H H
HH
Man in't Veld
A J
AJ
Boomsma
F
F
Schalekamp
M A
MA
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000420:Albuterol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D007008:Hypokalemia / Q000503:physiopathology*; D007545:Isoproterenol / Q000494:pharmacology; D011188:Potassium / Q000097:blood*; D011217:Practolol / Q000031:analogs & derivatives / Q000494:pharmacology; D011294:Prenalterol; D011433:Propranolol / Q000494:pharmacology; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D007545:Isoproterenol; D011294:Prenalterol; D000420:Albuterol; D011188:Potassium; D011217:Practolol; D004837:Epinephrine