Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis.
Palytoxon, which is a toxin with a molecular weight of 2681 daltons isolated from a marine coelenterate, is a potent skin irritant. However, it did not induce ornithine decarboxylase in mouse skin, or adhesion of human promyelocytic leukemia cells (HL-60). Moreover, it did not inhibit the specific binding of [3H]12-O-tetradecanoylphorbol-13-acetate (TPA) to a mouse skin particulate fraction or activate protein kinase C isolated from mouse brain in vitro. Since palytoxin showed strong irritation on mouse ear in one short-term screening test for a promoter, it was examined in a two-stage carcinogenesis experiment. The incidence of tumors in a group of mice treated with 7,12-dimethylbenz[a]anthracene plus palytoxin was 62.5% in week 25. These tumors were identified histologically as seven papillomas and one carcinoma. This paper reports the potent tumor-promoting activity of palytoxin, which is classified as a non-TPA-type tumor promoter.
Fujiki
H
H
Suganuma
M
M
Nakayasu
M
M
Hakii
H
H
Horiuchi
T
T
Takayama
S
S
Sugimura
T
T
D015127:9,10-Dimethyl-1,2-benzanthracene; D000178:Acrylamides; D000818:Animals; D002273:Carcinogens; D003064:Cnidarian Venoms / Q000633:toxicity*; D004790:Enzyme Induction; D005260:Female; D008235:Lyngbya Toxins / Q000633:toxicity; D051379:Mice; D008815:Mice, Inbred Strains; D009955:Ornithine Decarboxylase / Q000096:biosynthesis; D012878:Skin Neoplasms / Q000139:chemically induced*; D013755:Tetradecanoylphorbol Acetate / Q000378:metabolism; D000095702:Polyether Toxins
D015127:9,10-Dimethyl-1,2-benzanthracene; D000178:Acrylamides; D002273:Carcinogens; D003064:Cnidarian Venoms; D008235:Lyngbya Toxins; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate; C022176:teleocidins; C006610:aplysiatoxin; C010272:palytoxin; D000095702:Polyether Toxins