Lack of mast cell reactivity during leukemic infiltration of the rat mesentery under syngeneic and allogeneic conditions. A study by transmission electron microscopy (TEM).
The ultrastructural morphology of mast cells localized in rat mesenteries was studied after intraperitoneal implantation of L5222 rat leukemia cells in syngeneic and allogenic hosts. It became evident that the mast cells in the syngeneic (BDIX rat) as well as the allogeneic system (BN rat) showed nor morphological alterations. Degranulation was never observed. This is in contrast to the behavior of macrophages which displayed a strong phagocytotic activity in allogeneic hosts. Thus, it seems that mast cells, under the present experimental conditions, remained inactive during a phase of intense tumor rejection.
Zugmaier
G
G
Sträuli
P
P
Haemmerli
G
G
D000818:Animals; D007942:Leukemia, Experimental / Q000276:immunology* / Q000473:pathology; D008407:Mast Cells / Q000276:immunology* / Q000648:ultrastructure; D008643:Mesentery / Q000276:immunology*; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D051381:Rats; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic