title: Aridicins, novel glycopeptide antibiotics. III. Preparation, characterization, and biological activities of aglycone derivatives.
abstract: The aglycone and two pseudoaglycones of aridicin A were prepared by selective hydrolysis and characterized, chemically and biologically. These new analogs demonstrate improved activities in vitro over the parent antibiotics against methicillin sensitive and resistant staphylococci. The major determinant of activity is the mannose substituent, the presence of which results in less potent compounds. The analogs have potent activity against enterococci.
authors.forename: R D
authors.initials: RD
authors.lastname: Sitrin
authors.forename: G W
authors.initials: GW
authors.lastname: Chan
authors.forename: F
authors.initials: F
authors.lastname: Chapin
authors.forename: A J
authors.initials: AJ
authors.lastname: Giovenella
authors.forename: S F
authors.initials: SF
authors.lastname: Grappel
authors.forename: P W
authors.initials: PW
authors.lastname: Jeffs
authors.forename: L
authors.initials: L
authors.lastname: Phillips
authors.forename: K M
authors.initials: KM
authors.lastname: Snader
authors.forename: L J
authors.initials: LJ
authors.lastname: Nisbet
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D001439:Bacteroides / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003013:Clostridium / Q000187:drug effects; D003016:Clostridium perfringens / Q000187:drug effects; D005673:Fusobacterium / Q000187:drug effects; D006020:Glycopeptides / Q000032:analysis / Q000494:pharmacology; D006868:Hydrolysis; D008358:Mannose; D008712:Methicillin; D051379:Mice; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013203:Staphylococcal Infections / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; C046074:aridicins; D008358:Mannose; D008712:Methicillin