Behavioral indications for phenothiazine and benzodiazepine tranquilizers in dogs.
In a controlled study on 18 caged dogs, the effects of 2 psychoactive drugs on friendliness, excitability, and fearfulness were systematically and quantitatively evaluated. Diazepam was selected to represent the benzodiazepine group, and chlorpromazine represented the phenothiazine group. Diazepam was more effective in suppressing signs of fear than was chlorpromazine. Diazepam increased measures of excitability, whereas chlorpromazine had opposite effects.
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D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002707:Chlordiazepoxide / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004285:Dogs / Q000502:physiology*; D005239:Fear / Q000187:drug effects; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D006791:Hostility / Q000187:drug effects; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects
D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D000639:Amitriptyline; D008774:Methylphenidate; D002707:Chlordiazepoxide; D006220:Haloperidol; D003975:Diazepam; D002746:Chlorpromazine