Neuropeptide Y does not inhibit the release of alpha-MSH from the pars intermedia of the rat adenohypophysis.
Neuropeptide Y in concentrations from 10(-8) to 10(-6) M inhibits the release of alpha-MSH from the frog (Rana pipiens) pituitary in a reversible, sustained, and concentration-related manner. However, it does not inhibit the release of alpha-MSH from the rat pars intermedia. Thus, while neuropeptide Y may play a role in the control of alpha-MSH release in amphibia, it appears not to be a regulatory peptide for the mammalian pars intermedia.
Kraicer
J
J
Department of Physiology, University of Western Ontario, London, Canada.
Lussier
B
B
Kotanen
S
S
Moor
B C
BC
D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D009478:Neuropeptide Y / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D011894:Rana pipiens; D051381:Rats; D000521:alpha-MSH / Q000378:metabolism*
D009478:Neuropeptide Y; D000521:alpha-MSH