Growth-hormone releasing factor does not antagonize somatostatin effects on pancreatic and gastric secretions.
The effect of human GRF 44 upon somatostatin-inhibited pancreatic and gastric secretions was studied in rats with chronic fistulas. GRF did not show any antagonist action of somatostatin on these gastro-intestinal organs. GRF alone had a small inhibitory effect on gastric acid output.
Chovet
M
M
Dubrasquet
M
M
Chariot
J
J
Rozé
C
C
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D005744:Gastric Acid / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D001639:Bicarbonates; D010446:Peptide Fragments; D013004:Somatostatin; D013007:Growth Hormone-Releasing Hormone