[Severe chronic Epstein-Barr virus infection with natural killer cell defect].
Chronic Epstein-Barr virus infection was confirmed serologically in a 27-year-old man with pneumonia, splenomegaly, pancytopenia, arthritis, neuropathy and psychological changes. Immunological tests revealed a defect in the cytotoxic activity of the natural killer cells. Treatment with high doses of acyclovir intravenously and of antimycotic drugs dramatically and lastingly improved the patient's condition.
Hartung
K
K
Abteilung Immunologie und Transfusionsmedizin, Medizinischen Hochschule Hannover.
Le Blanc
S
S
Franz
A
A
Jacobs
R
R
Wittekind
C
C
Bornkamm
G W
GW
Schmidt
R E
RE
D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D002908:Chronic Disease; D003601:Cytotoxicity Tests, Immunologic; D003937:Diagnosis, Differential; D006566:Herpesviridae Infections / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D004854:Herpesvirus 4, Human; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male
D000212:Acyclovir
Schwere chronische Epstein-Barr-Virus-Infektion mit Natural-Killer-Zell-Defekt.