Hepatocellular carcinoma in a child with familial Russell-Silver syndrome.
We describe a 4-year-old boy with Russell-Silver syndrome (RSS) found to have hepatocellular carcinoma. The brother of this child also had manifestations of RSS. This is the third malignancy and the first hepatocellular carcinoma described in a patient with RSS. The coexistence of hepatocellular carcinoma and RSS may be completely fortuitous; however, the known association of liver cancer with growth abnormality and hemihypertrophy, findings also present in RSS, suggest that these disorders may be related.
Chitayat
D
D
University of British Columbia Clinical Genetics Unit, Grace Hospital, Vancouver, B.C., Canada.
Friedman
J M
JM
Anderson
L
L
Dimmick
J E
JE
D000015:Abnormalities, Multiple / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000235:genetics; D002675:Child, Preschool; D004423:Ear / Q000002:abnormalities; D005145:Face / Q000002:abnormalities; D006130:Growth Disorders / Q000150:complications* / Q000235:genetics; D006226:Hand Deformities / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000235:genetics; D008297:Male