title: A combined glucagonoma and VIPoma syndrome. First pathologic and clinical report.
abstract: We report a case of pancreatic tumour metastatic to the liver in a patient with insulin-treated diabetes, anaemia, cheilitis, necrolytic migratory erythema, hypokalemia and chronic watery diarrhea, a picture suggesting combined glucagonoma and VIPoma syndromes. Immunocytochemistry of a biopsied hepatic metastatic nodule revealed both glucagon and vasoactive intestinal peptide (VIP) positive cells. Increased plasma glucagon and VIP levels were detected (values of 900 pmol/l and 277 pmol/l respectively). This is the first reported case showing not only immunocytochemical, but also clinical evidence of the combined secretion of these hormones.
authors.affiliation: Institute of Internal Medicine, University of Turin, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Cavallo-Perin
authors.forename: M
authors.initials: M
authors.lastname: De Paoli
authors.forename: G
authors.initials: G
authors.lastname: Guiso
authors.forename: A
authors.initials: A
authors.lastname: Sapino
authors.forename: M
authors.initials: M
authors.lastname: Papotti
authors.forename: R
authors.initials: R
authors.lastname: Coda
authors.forename: G
authors.initials: G
authors.lastname: Pagano
mesh_terms: D007516:Adenoma, Islet Cell / Q000378:metabolism*; D005935:Glucagonoma / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D003969:Vipoma / Q000378:metabolism*