The anti-oedematogenic effect of SRS as an additional factor in the mode of action of non-steroid anti-inflammatory drugs.
A partially purified preparation of SRS was obtained from peritoneal exudates induced by a non-anaphylactic immediate hypersensitivity reaction. This preparation injected in the rat skin caused vasoconstriction and when administered together with carrageenin reduced oedema formation. Injection of carrageenin into the peritoneal cavity progressively increased exudate formation. Pretreatment of the animals with anti-inflammatory doses of aspirin, indomethacin and salicylate significantly reduced exudate formation and this inhibition was correlated with the appearance of SRS in the exudates. It is suggested that, in some inflammatory exudates, stimulation of the synthesis of vasoconstrictor SRS might be an additional factor to the inhibition of prostaglandin synthesis induced by non-steroid anti-inflammatory drugs.
Jancar
S
S
Faccioli
L H
LH
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001202:Ascitic Fluid / Q000378:metabolism; D012898:Autacoids / Q000302:isolation & purification / Q000378:metabolism / Q000502:physiology*; D002199:Capillary Permeability; D002351:Carrageenan; D016861:Cyclooxygenase Inhibitors; D004487:Edema / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D012898:Autacoids; D016861:Cyclooxygenase Inhibitors; D002351:Carrageenan