Glucocorticoids stimulate the growth of mouse mammary carcinoma Shionogi cells in culture.
The relative potency of a series of glucocorticoids to stimulate the growth of a cloned cell line (SEM-1) derived from the androgen-sensitive Shionogi mouse mammary carcinoma is proportional to their known affinity for the glucocorticoid receptor. The stimulatory action of glucocorticoids is not inhibited by the pure antiandrogen hydroxyflutamide while the antiglucocorticoids RU25593 and RU38486 cause 100% and 80% inhibitions of the activity of triamcinolone acetonide, respectively, thus indicating that the stimulatory effect of glucocorticoids on Shionogi cell growth is mediated by the glucocorticoid receptor. Such data indicate that not only androgens but also glucocorticoids should be taken into account when assessing the endocrine control of the growth of these mammary carcinoma cells.
Labrie
F
F
MRC Group in Molecular Endocrinology, Laval University Medical Center, Quebec, Canada.
Veilleux
R
R
Fournier
A
A
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000728:Androgens / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D005938:Glucocorticoids / Q000494:pharmacology*; D006128:Growth / Q000187:drug effects*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000503:physiopathology; D051379:Mice; D010902:Pituitary Gland / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000728:Androgens; D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone