Amphetamine-induced circling behaviour in MPTP-lesioned mice.
This study was designed to examine the effect of intrastriatal administration of MPTP on (+)-amphetamine-induced circling behaviour in mice. The results demonstrate that (+)-amphetamine elicits circling behaviour in MPTP-lesioned animals. MPTP produced a 70% depletion of striatal dopamine concentration.
Fung
Y K
YK
Troxel
C E
CE
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011725:Pyridines / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects*
D011725:Pyridines; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000661:Amphetamine; D003913:Dextroamphetamine; D004298:Dopamine