Splanchnic nerve stimulation inhibits duodenal HCO3- secretion in the rat.
Sympathoadrenergic inhibition of HCO3- secretion by the duodenal mucosa was studied in chloralose anesthetized rats. Duodenal HCO3- secretion was measured in situ by pH-stat titration. Direct efferent electrical stimulation of the cut splanchnic nerves (10 Hz, supramaximal intensity) inhibited the duodenal alkaline output by approximately 50%. This inhibitory response was blocked by the administration of either the adrenolytic agent guanethidine or the alpha 2-adrenoceptor antagonist yohimbine. However, neither the alpha 1-adrenoceptor antagonist prazosin nor the beta-adrenoceptor antagonist propranolol blocked the response to splanchnic nerve stimulation. The present data suggest that electrical splanchnic nerve stimulation inhibits duodenal HCO3- secretion via activation of adrenergic nerve fibers and alpha 2-adrenoceptors within the peripheral nervous system.
Jönson
C
C
Department of Physiology, University of Göteborg, Sweden.
Fändriks
L
L
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism*; D001794:Blood Pressure; D004386:Duodenum / Q000294:innervation* / Q000378:metabolism; D004558:Electric Stimulation; D006339:Heart Rate; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013153:Splanchnic Nerves / Q000502:physiology*
D001639:Bicarbonates