title: Effects of changes in dietary sodium intake and saline infusion on immunoreactive atrial natriuretic peptide in human plasma.
abstract: Plasma levels of immunoreactive atrial natriuretic peptide (IrANP) were measured in healthy normotensive subjects before and after saline infusion and changes in dietary salt intakes. When 2 litres of 0.9% saline (308 mmol Na+) were infused over 1 h, plasma levels (mean +/- SD) of IrANP increased from 5.8 +/- 2.8 pg/ml to 15.8 +/- 12.5 pg/ml. Plasma levels on the fifth day of a low sodium diet (10 mmol/day) were 3.8 +/- 2.4 pg/ml, a normal sodium intake (150 mmol/day) 6.4 +/- 2.9 pg/ml, and a high salt intake (350 mmol/day) 12.7 +/- 6 pg/ml. These results suggest that atrial natriuretic peptides could be important hormones in the control of sodium balance in normal man.
authors.forename: G A
authors.initials: GA
authors.lastname: Sagnella
authors.forename: N D
authors.initials: ND
authors.lastname: Markandu
authors.forename: A C
authors.initials: AC
authors.lastname: Shore
authors.forename: G A
authors.initials: GA
authors.lastname: MacGregor
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000276:immunology; D004032:Diet; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D012964:Sodium / Q000008:administration & dosage*
chemical_list: D009320:Atrial Natriuretic Factor; D012964:Sodium