Regional cerebral blood flow during acute left ventricular failure in the dog: effect of converting enzyme inhibition.
Regional cerebral blood flow (rCBF) was studied in anesthetized dogs subjected to acute left ventricular failure and its treatment with enalaprilat (MK-422). When failure was induced a reduction in rCBF paralleling the reduction in systemic blood pressure was observed. After treatment rCBF did not change in spite of further blood pressure reduction. The results are explained by changes in vascular resistance of larger cerebral arteries. Vasoconstriction in these vessels during failure was counteracted by enalaprilat through reduction in circulating angiotensin II.
Hall
C
C
Institute for Surgical Research, University of Oslo, Norway.
Mørkrid
L
L
Zwetnow
N N
NN
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D002303:Cardiac Output, Low / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004285:Dogs; D004656:Enalapril / Q000031:analogs & derivatives / Q000494:pharmacology; D015773:Enalaprilat; D006352:Heart Ventricles; D006439:Hemodynamics / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril; D015773:Enalaprilat