title: Somatostatin binding sites in cytosolic fractions of parietal and non-parietal cells from rabbit fundic mucosa.
abstract: Specific binding sites for somatostatin have been found in the cytosolic fractions of both parietal and non-parietal cells from rabbit gastric fundic mucosa. The stoichiometric data suggested the presence of two classes of binding sites in both types of cells. The number of low-affinity binding sites was significantly higher in parietal cells than in non-parietal cells. The reverse was true for the high-affinity binding sites. However, the affinity of each class of binding sites was similar in the cytosolic fractions of both parietal and non-parietal cells. It thus appears that low-affinity somatostatin binding sites are mainly located in the parietal cells whereas the high-affinity sites occur principally in the non-parietal cells.
authors.forename: E
authors.initials: E
authors.lastname: Arilla
authors.forename: M P
authors.initials: MP
authors.lastname: López-Ruiz
authors.forename: L
authors.initials: L
authors.lastname: Gonzalez-Guijarro
authors.forename: J C
authors.initials: JC
authors.lastname: Prieto
mesh_terms: D000818:Animals; D001665:Binding Sites; D003600:Cytosol / Q000378:metabolism; D005748:Gastric Fundus / Q000166:cytology / Q000378:metabolism; D005753:Gastric Mucosa / Q000166:cytology / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011817:Rabbits; D013004:Somatostatin / Q000378:metabolism*
chemical_list: D013004:Somatostatin