[Effect of excitant amino acid antagonists on glutamate receptors in the locust and on convulsions induced by glutamate, aspartate, kynurenine and quinolinic acid in mice].
All excitatory amino acid antagonists studied: diethyl esters of aspartic (DEEA) and glutamic (DEEG) acids, 2-amino-3-phosphono-propionic acid (APPA) and 2-amino-4-phosphono-butanoic acid (APBA), diminished the amplitude of excitatory postsynaptic potentials (EPP) of the locust (Locusta migratoria migratorioides) muscle fibers and arbitrary blocked glutamate (GLU) and aspartate (ASP) responses. Kynurenine (KYN) and quinolinic (QUI) acid had no effect on EPP even at a concentration of 2 X 10(-2) M. The antagonists were not strictly selective against intracerebroventricularly administered endogenous convulsants: GLU, ASP, KYN and QUI and in simulation of experimental seizures in mice. The antagonists structurally similar to ASP prevented ASP- and KYN-induced seizures in lower doses than GLU derivatives. Anti-KYN, but not anti-QUI DEEA, DEEG, APPA and APBA efficacy suggests that KYN and QUI act on different structures or binding sites.
Ryzhov
I V
IV
Slepokurov
M V
MV
Lapin
I P
IP
Mandel'shtam
Iu E
IuE
Aleksandrov
V G
VG
D000409:Alanine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D000596:Amino Acids / Q000037:antagonists & inhibitors*; D000613:Aminobutyrates / Q000037:antagonists & inhibitors; D000818:Animals; D001224:Aspartic Acid / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005971:Glutamates / Q000378:metabolism* / Q000633:toxicity*; D018698:Glutamic Acid; D006110:Grasshoppers / Q000187:drug effects*; D007737:Kynurenine / Q000633:toxicity*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D009132:Muscles / Q000187:drug effects; D011725:Pyridines / Q000633:toxicity*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000633:toxicity*; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
D000596:Amino Acids; D000613:Aminobutyrates; D005971:Glutamates; D011725:Pyridines; D011805:Quinolinic Acids; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; C000211:2-amino-3-phosphonopropionic acid; D001224:Aspartic Acid; D007737:Kynurenine; D018698:Glutamic Acid; D017378:Quinolinic Acid; C012729:2-amino-4-phosphonobutyric acid; D000409:Alanine
Vliianie antagonistov vozbuzhdaiushchikh aminokislot na glutamatnye retseptory saranchi i sudorogi, vyzvannye glutamatom, aspartatom, kinureninom i khinolinovoĭ kislotoĭ na myshakh.