Identification of the human hepatic microsomal glucose-6-phosphatase enzyme.
The glucose-6-phosphatase enzyme protein of the human hepatic microsomal glucose-6-phosphatase system was identified as a 36.5 kDa polypeptide. The 36.5 kDa glucose-6-phosphatase enzyme protein was shown to be absent in the microsomes isolated from a patient previously diagnosed as having a type 1a glycogen storage disease.
Burchell
A
A
Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland.
Waddell
I D
ID
Countaway
J L
JL
Arion
W J
WJ
Hume
R
R
D000818:Animals; D001665:Binding Sites; D004591:Electrophoresis, Polyacrylamide Gel; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates / Q000378:metabolism; D005953:Glycogen Storage Disease Type I / Q000201:enzymology*; D006801:Humans; D015151:Immunoblotting; D008862:Microsomes, Liver / Q000201:enzymology*; D010761:Phosphorus Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains
D005958:Glucosephosphates; D010761:Phosphorus Radioisotopes; D019298:Glucose-6-Phosphate; D005952:Glucose-6-Phosphatase