Effect of DL-erythro-dihydroxyphenylserine on the locomotor activity of the mouse.
Effect of dihydroxyphenylserine (DOPS) on the locomotor activity of mice pretreated with beta-phenylisopropylhydrazine was studied using an Animex activity meter. An intraperitoneal injection of DL-erythro-DOPS (200 mg/kg) suppressed significantly the locomotor stimulation by the MAO inhibitor, while DL-threo-DOPS (200 mg/kg) had no effect. Only slight suppression was observed after the administration of 100 mg/kg of DL-erythro-DOPS. Effect of DOPS on the concentrations of brain catecholamines and serotonin of mice pretreated with the MAO inhibitor was also analysed. The administration of DL-erythro-DOPS significantly increased the concentration of noradrenaline, while DL-threo-DOPS did not affect the contents of brain amines in the experimental condition. The suppressive effect of DL-erythro-DOPS on the locomotor stimulation by the MAO inhibitor was confirmed by a simultaneous administration of the amino acid and d-phenylisopropylmethylamine to mice. Based on these findings, the neural mechanisms of the locomotor activity and a clinical application of DL-erythro-DOPS to the manic syndrome were discussed.
Mori
T
T
Nakajima
T
T
Hashimoto
H
H
Noto
T
T
Kato
N
N
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D015103:Droxidopa / Q000494:pharmacology*; D004347:Drug Interactions; D006834:Hydrazines / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009638:Norepinephrine / Q000378:metabolism; D012110:Reserpine / Q000494:pharmacology; D012694:Serine / Q000031:analogs & derivatives*; D012701:Serotonin / Q000378:metabolism
D000596:Amino Acids; D002395:Catecholamines; D006834:Hydrazines; D012701:Serotonin; D008694:Methamphetamine; D012694:Serine; D012110:Reserpine; D015103:Droxidopa; D004298:Dopamine; D009638:Norepinephrine