Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo.
There are two genes related to the viral erbB gene in the human genome. c-erbB-1 is the same as the gene for the epithelial-growth-factor (EGF) receptor, and c-erbB-2 encodes a receptor-like protein very similar to, but distinct from, the EGF receptor. Hybridisation analysis of DNA from 101 fresh human malignant tumours showed that the c-erbB-2 gene was amplified in 5 of 63 adenocarcinomas and none of 38 other types of tumours, whereas the c-erbB-1/EGF-receptor gene was amplified only in 1 of 8 squamous-cell carcinomas. Thus, the protein products of the amplified c-erbB-2 gene may have a role in the evolution of adenocarcinomas, as does the EGF receptor in some squamous-cell carcinomas.
Yokota
J
J
Yamamoto
T
T
Toyoshima
K
K
Terada
M
M
Sugimura
T
T
Battifora
H
H
Cline
M J
MJ
D000230:Adenocarcinoma / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics; D004279:DNA, Viral / Q000032:analysis; D066246:ErbB Receptors; D005784:Gene Amplification; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics; D009693:Nucleic Acid Hybridization; D011518:Proto-Oncogene Proteins / Q000032:analysis; D011519:Proto-Oncogenes; D011956:Receptors, Cell Surface / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics
D004279:DNA, Viral; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D066246:ErbB Receptors