Platelet-derived growth factor: a multifunctional regulator of normal and abnormal cell growth.
Polypeptide growth factors, which are synthesized and secreted both by normal and transformed cells, have a multiplicity of roles in normal and abnormal cell growth. Platelet-derived growth factor (PDGF) is nearly identical to the transforming gene (oncogene) product of simian sarcoma virus p28v-sis. Binding of PDGF to high-affinity cell surface PDGF receptors stimulates the intrinsic autophosphorylating protein tyrosine kinase activity of these receptors and sets off a cascade of metabolic events. Among these events are induction of otherwise quiescent genes which regulate synthesis of transcriptional factors and thus are critical in cell division, differentiation and development.
Deuel
T F
TF
Department of Medicine and Biological Chemistry, Jewish Hospital, Washington University Medical Center, St Louis, MO 63110.
Silverman
N J
NJ
Kawahara
R S
RS
D000818:Animals; D001483:Base Sequence; D001792:Blood Platelets / Q000032:analysis; D002455:Cell Division; D002461:Cell Line, Transformed; D006224:Cricetinae; D005786:Gene Expression Regulation; D006801:Humans; D010982:Platelet-Derived Growth Factor / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology; D017479:Receptors, Platelet-Derived Growth Factor; D012689:Sequence Homology, Nucleic Acid
D010982:Platelet-Derived Growth Factor; D011956:Receptors, Cell Surface; D017479:Receptors, Platelet-Derived Growth Factor