MHC class I and class II antigen expression in normal human corneas and in corneas from cases of herpetic keratitis.
The expression of HLA class I and class II antigens in corneas from normal donors and patients with quiescent herpetic keratitis was investigated using specific monoclonal antibodies. Keratocytes from diseased corneas showed aberrant expression of HLA class I and class II (DR, DP and DQ) antigens. The expression of HLA antigens in these corneas was not associated with immune cell infiltrates or viral antigens.
McBride
B W
BW
University Department of Medical Microbiology, Southampton General Hospital.
McGill
J I
JI
Smith
J L
JL
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D000956:Antigens, Viral / Q000032:analysis; D003315:Cornea / Q000276:immunology*; D006681:HLA-D Antigens / Q000032:analysis*; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D006801:Humans; D007635:Keratitis, Dendritic / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008875:Middle Aged; D018139:Simplexvirus / Q000276:immunology
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D006681:HLA-D Antigens; D015395:Histocompatibility Antigens Class I