Single nocturnal doses of pirenzepine effectively inhibit overnight gastric secretion.
The gastric antisecretory effects of two dose levels of pirenzepine given at night were investigated in a group of healthy male volunteers. Compared with placebo, three days of treatment with pirenzepine 100 mg nocte or 150 mg nocte inhibited mean nocturnal intragastric acidity by 54% and 53%, respectively (p less than 0.01). The volume of gastric juice secreted was reduced by 47% and 52% (p less than 0.005), by 100 mg and 150 mg nocte, respectively. Each dose suppressed mean gastric acid output by 67% (p less than 0.001). Pepsin output was not significantly altered. There were no differences in effect between the two dose levels studied, but side-effects such as dry mouth were only seen with the higher dose. Pirenzepine 100 mg is the optimum dose which can conveniently be given at night. This will limit side-effects, and may be a useful treatment for patients with duodenal ulcer.
Howden
C W
CW
Burget
D W
DW
Silletti
C
C
Hunt
R H
RH
D000328:Adult; D001570:Benzodiazepinones / Q000008:administration & dosage* / Q000494:pharmacology; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D008297:Male; D010437:Peptic Ulcer / Q000188:drug therapy; D010890:Pirenzepine; D013997:Time Factors
D001570:Benzodiazepinones; D006635:Histamine H2 Antagonists; D010890:Pirenzepine