Stress by forced swimming in the rat: effects of mianserin and moclobemide on GABAergic-monoaminergic systems in the brain.
The stress caused by forced swimming in male rats provoked a decrease in brain NA levels without changes in DA and 5-HT content, MAO and GABAergic activity. Acute or chronic treatment with mianserin did not modify the decrease in NA concentration in the brain of stressed rats. Acute treatment with moclobemide (IMAO) did not modify the decrease in NA content caused by stress; chronic treatment blocked the decrease in NA content in stressed rats.
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D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D001679:Biogenic Amines / Q000502:physiology*; D001923:Brain Chemistry / Q000187:drug effects; D003984:Dibenzazepines / Q000494:pharmacology*; D005968:Glutamate Decarboxylase / Q000378:metabolism; D008297:Male; D008803:Mianserin / Q000494:pharmacology*; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*; D013550:Swimming; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D001549:Benzamides; D001679:Biogenic Amines; D003984:Dibenzazepines; D008996:Monoamine Oxidase Inhibitors; D008803:Mianserin; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase; D020912:Moclobemide