Suppressive effect of indazole adenine dinucleotides on proliferation of normal and malignant cells.
The suppressive effects of newly synthesized NAD-analogs, indazole adenine dinucleotides (IAD), on the cellular proliferation of normal and L5178Y cells were investigated in connection with their inhibitory activity on inosine 5'-monophosphate dehydrogenase (IMPD). All the dinucleotides, except compounds VIII and IX, were observed to show a certain extent of suppression at a concentration of 100 micrograms/ml. In particular, some compounds (II, VII, X and XI) among them showed a strong suppression (70-90%) in the leukemic cell system. The suppression seemed to be roughly correlative with the degree of IMPD inhibition of the dinucleotide.
Tono-Oka
S
S
Tone
Y
Y
Azuma
I
I
D000227:Adenine Nucleotides / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors; D007191:Indazoles / Q000494:pharmacology*; D007940:Leukemia L5178 / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D011720:Pyrazoles / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013329:Structure-Activity Relationship
D000227:Adenine Nucleotides; D007191:Indazoles; D011720:Pyrazoles; D007168:IMP Dehydrogenase