A comparison of nalbuphine and morphine as premedication agents for minor gynaecological surgery.
Nalbuphine 10 mg and morphine 10 mg were compared in a randomised double-blind trial as intramuscular premedication in 50 patients undergoing minor gynaecological surgery. Both nalbuphine and morphine produced significant sedation without anxiolysis as assessed by patient linear analogue scales, but there were no significant differences between the two drugs. Observer ratings demonstrated that nalbuphine produced calm/sleepy patients to a greater extent than morphine. There were no differences in untoward effects produced by each drug.
Pinnock
C A
CA
Bell
A
A
Smith
G
G
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D002986:Clinical Trials as Topic; D004107:Dilatation and Curettage; D004244:Dizziness / Q000139:chemically induced; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008875:Middle Aged; D009019:Morphinans / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D009266:Nalbuphine / Q000494:pharmacology; D011229:Preanesthetic Medication; D011897:Random Allocation; D012890:Sleep / Q000187:drug effects
D014151:Anti-Anxiety Agents; D009019:Morphinans; D009020:Morphine; D009266:Nalbuphine