title: Treatment of Askin Rosai tumor--need for a more aggressive approach.
abstract: Fifteen cases of histologically proven Askin Rosai tumor were treated at Tata Memorial Hospital over a period of 3 years. Patients included 12 men and three women. Clinical features included chest wall mass (14), pain (11), bony involvement (6), fever (4), dyspnoea (4), weight loss (1), cough (1), and hemoptysis (1). Previously treated patients received different treatment protocols, which made evaluation difficult. Of our ten patients who have completed induction therapy, five received vincristine and cyclophosphamide, whereas the other five received more aggressive chemotherapy. Complete remission has been achieved in two and four of these patients, respectively. One patient in each group had recurrence of the disease, in both cases at the local site. Thus, from our preliminary data, we suggest that Askin Rosai tumor should be treated with complete surgical excision followed by an aggressive combination of chemotherapy and local radiotherapy.
authors.affiliation: Department of Medical Oncology, Tata Memorial Hospital, Bombay, India.
authors.forename: P M
authors.initials: PM
authors.lastname: Parikh
authors.forename: B S
authors.initials: BS
authors.lastname: Charak
authors.forename: S D
authors.initials: SD
authors.lastname: Banavali
authors.forename: S H
authors.initials: SH
authors.lastname: Advani
authors.forename: T K
authors.initials: TK
authors.lastname: Saikia
authors.forename: R
authors.initials: R
authors.lastname: Gopal
authors.forename: A M
authors.initials: AM
authors.lastname: Borges
authors.forename: R F
authors.initials: RF
authors.lastname: Chinoy
authors.forename: P B
authors.initials: PB
authors.lastname: Desai
mesh_terms: D000293:Adolescent; D000328:Adult; D018288:Carcinoma, Small Cell / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D008297:Male