Mechanism of action of the antiviral compound MDL 20,610.
The purpose of this study was to probe the antirhinovirus (RV) mechanism of action of MDL 20,610. Evaluation of the compound's effects on RV RNA synthesis, uncoating of neutral red-sensitized RV, plasma membrane penetration by RV, stabilization of RV against heat (56 degrees C) and low pH (5.0) inactivation, and studies with MDL 20,610-resistant RV mutants indicate that MDL 20,610 binds directly to the RV capsid with subsequent inhibition of acid-mediated virion uncoating.
Kenny
M T
MT
Department of Pharmacology, Merrell Dow Research Institute, Indianapolis, Indiana 46268-0470.
Torney
H L
HL
Dulworth
J K
JK
D000998:Antiviral Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006367:HeLa Cells; D006358:Hot Temperature; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009154:Mutation; D011725:Pyridines / Q000494:pharmacology*; D012367:RNA, Viral / Q000096:biosynthesis; D012229:Rhinovirus / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism
D000998:Antiviral Agents; D011725:Pyridines; D012367:RNA, Viral; C050725:MDL 20610