Beta-lactam resistance mechanisms in gram-negative bacteria.
Beta-lactam antibiotics are commonly used to treat a variety of bacterial infections. Gram-negative bacteria have evolved several resistance mechanisms including altered permeability and beta-lactamase production. New trends in resistance are emerging amongst clinical isolates which may reflect the choice of beta-lactam employed.
Cole
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ST
Unité des Applications du Génie Génétique, Institute Pasteur, Paris, France.
Nicolas
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MH
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002463:Cell Membrane Permeability; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000378:metabolism; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams