title: Vasodilators in hypertension--a review with special emphasis on the combined use of vasodilators and beta-adrenoceptor blockers.
abstract: This paper presents a review of studies dealing with combined beta-adrenoceptor blockade and vasodilatation in the treatment of hypertension. This therapy can be achieved either through the combined use of conventional beta-adrenoceptor blocking compounds given together with vasodilator drugs or with agents which show multiple action of this kind. From a hemodynamic point of view this therapeutic approach is quite logical since most forms of established hypertension are characterized by increased vascular resistance. It can therefore be concluded that combined beta-adrenoceptor blockade and vasodilation offers a rational and useful treatment of hypertension.
authors.forename: R
authors.initials: R
authors.lastname: Eggertsen
authors.forename: L
authors.initials: L
authors.lastname: Hansson
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002227:Carbazoles / Q000627:therapeutic use; D000077261:Carvedilol; D003981:Diazoxide / Q000627:therapeutic use; D004078:Dihydralazine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006146:Guanidines / Q000627:therapeutic use; D006801:Humans; D006830:Hydralazine / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy*; D008914:Minoxidil / Q000627:therapeutic use; D020110:Pinacidil; D010953:Plasma Volume / Q000187:drug effects; D011412:Propanolamines; D011724:Pyridazines / Q000627:therapeutic use; D012084:Renin-Angiotensin System / Q000187:drug effects; D012702:Serotonin Antagonists / Q000627:therapeutic use; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002121:Calcium Channel Blockers; D002227:Carbazoles; D006146:Guanidines; D011412:Propanolamines; D011724:Pyridazines; D012702:Serotonin Antagonists; D014665:Vasodilator Agents; D000077261:Carvedilol; D006830:Hydralazine; D008914:Minoxidil; D020110:Pinacidil; C024293:prizidilol; D003981:Diazoxide; D004078:Dihydralazine