[Dipeptidyl peptidase IV activity in the serum and synovia of patients with rheumatoid arthritis].
Over 90 patients with rheumatoid arthritis (RA) were examined to ascertain the activity of the enzyme dipeptidylpeptidase IV (DP IV) (EC number: 3.4.14.-) in serum and synovial fluid. If the activity stage of RA (clinical and paraclinical picture) is on the increase, the gly-pro-NHNp-hydrolysis in serum and synovial fluid decreases. Indirect statistical connections between the cytological activity stage and the DP IV activity are detectable. Although the enzyme from the serum with the molecular weight of 270 kD can only filter scantily into the synovia, there is an intraindividual connection between the enzyme activity in the synovial fluid and serum. With the aid of combined experiments the effect of the endogenous inhibitors can be excluded.
Küllertz
G
G
Boigk
J
J
D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000201:enzymology*; D018819:Dipeptidyl Peptidase 4; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000097:blood*; D006801:Humans; D007700:Kinetics; D013582:Synovial Fluid / Q000166:cytology / Q000201:enzymology*
D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D018819:Dipeptidyl Peptidase 4
Dipeptidylpeptidase IV-Aktivität in Serum und Synovia bei Patienten mit rheumatoider Arthritis.