title: Podophyllotoxins for brain metastases of small cell lung cancer.
abstract: A patient with brain metastases of small cell lung cancer (SCLC) responded initially to cranial irradiation. Recurrences were subsequently successfully treated with high-dose intravenous etoposide (VP 16-213) and teniposide (VM 26). Epipodophyllotoxins are potentially useful for CNS metastases of SCLC.
authors.affiliation: Department of Neurology, University Hospital, Groningen, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Haaxma-Reiche
authors.forename: H H
authors.initials: HH
authors.lastname: Berendsen
authors.forename: P E
authors.initials: PE
authors.lastname: Postmus
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D005047:Etoposide / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011034:Podophyllotoxin / Q000031:analogs & derivatives*; D013713:Teniposide / Q000627:therapeutic use*
chemical_list: D005047:Etoposide; D013713:Teniposide; D011034:Podophyllotoxin