Triazolam and ethanol interaction: kinetic and dynamic consequences.
The kinetic and dynamic consequences of the coadministration of triazolam and ethanol were investigated in six normal subjects. Each received three treatments: triazolam, 0.25 mg by mouth, preceded by 1 hour and followed for 7.5 hours by oral ethanol dosed to maintain breath concentrations of 800 to 950 mg/L; placebo and ethanol; and triazolam and orange juice. After ethanol, triazolam total AUC0-infinity increased (mean +/- SD = 21% +/- 18%). Subjects showed greater psychomotor impairment on measures of free recall, postural stability, and hand-eye coordination after the combination than after either drug alone. These dynamic interactions are greater than the kinetic changes.
Dorian
P
P
Sellers
E M
EM
Kaplan
H L
HL
Hamilton
C
C
Greenblatt
D J
DJ
Abernethy
D
D
D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D014151:Anti-Anxiety Agents / Q000378:metabolism*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D011897:Random Allocation; D014229:Triazolam / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D014229:Triazolam; D000431:Ethanol