Effects of GABA compounds injected into the subpallidal regions of rat brain on nucleus accumbens evoked hyperactivity.
The effects of administration of gamma-aminobutyric acid (GABA) compounds into the ventral pallidum and substantia innominata on the locomotor hyperactivity induced by the dopamine agonist 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN) in the nucleus accumbens were investigated in rats. Hyperactivity induced by ADTN was antagonized by the GABA receptor agonists muscimol, isoguvacine, and baclofen. The compounds were equally effective in both subpallidal regions. In contrast, the GABA antagonists picrotoxin and bicuculline injected into subpallidal sites had no effects on accumbens-evoked hyperactivity, although by themselves both antagonists caused a mild and transient locomotor stimulation. It is suggested that GABA receptors in the subpallidal areas are involved in locomotor stimulation elicited from the nucleus accumbens.
Patel
S
S
Department of Physiology, University of Manchester, United Kingdom.
Slater
P
P
D000818:Animals; D001143:Arousal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005917:Globus Pallidus / Q000187:drug effects*; D007267:Injections; D009043:Motor Activity / Q000187:drug effects*; D009281:Naphthalenes / Q000494:pharmacology*; D009434:Neural Pathways / Q000187:drug effects; D009714:Nucleus Accumbens / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects*; D012686:Septal Nuclei / Q000187:drug effects*; D013377:Substantia Innominata / Q000187:drug effects; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D009281:Naphthalenes; D011963:Receptors, GABA-A; D013764:Tetrahydronaphthalenes; C011639:ADTN