Synthesis of 1H-pyrazolo[4,3-d]pyrimidine-7(6H)-ones and pyrazolo-5-carboxamides and interaction with benzodiazepine and adenosine A1 receptors in rat cerebral cortex.
The effects of several newly synthesized pyrazolo [4,3-d] pyrimidine-7-ones and pyrazolo-5-carboxamides on [3H]-flunitrazepam and [3H]-cyclohexyladenosine binding in rat cerebral cortex membranes have been studied. The compounds under examination, displaying affinities in the micromolar range for both benzodiazepine and adenosine A1 receptors, could be of interest in the study of a possible link between the two receptor systems.
Baraldi
P G
PG
Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy.
Casolari
A
A
Manfredini
S
S
Periotto
V
V
Zanirato
V
V
Florio
C
C
Traversa
V
V
Bertelli
G M
GM
Borea
P A
PA
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002540:Cerebral Cortex / Q000378:metabolism*; D004347:Drug Interactions; D008297:Male; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D011983:Receptors, Purinergic / Q000378:metabolism*
D011720:Pyrazoles; D011743:Pyrimidines; D011963:Receptors, GABA-A; D011983:Receptors, Purinergic; C027180:7-ketopyrazolo(4,3-d)pyrimidine