Prevention of T-cell lymphoma in AKR/J mice.
Injection of a dual tropic virus (DTV) isolated from a T cell lymphoma AKR/J mice into the thymus of 14 day old AKR/J puppies accelerates lymphoma development; 90-100% of the injected mice develop the disease within 120 days. In contrast a cell free centrifuge CFC-666 prepared B cell lymphoma of AKR/J origin injected into the thymus of 14 day old AKR/J mice failed to accelerate T cell lymphomagenesis and actually prevented the spontaneous T cell lymphoma development. However, 50% of the treated mice developed B cell lymphoma with a latency of 417 + 18 days. DTV injection induces amplification of thymic expression of MuLV related antigens, besides changes in thymus subpopulation. Such changes emerge spontaneously in 5-6 month preleukemic AKR/J mice (at the time of spontaneous DTV formation in the thymus). These changes in the thymus were not observed following CFC-666 injection. We assume therefore that CFC-666 interferes with spontaneous DTV formation that contributes to T cell lymphomagenesis.
Peled
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A
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
Haran-Ghera
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N
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D001402:B-Lymphocytes / Q000382:microbiology; D005260:Female; D006183:H-2 Antigens / Q000032:analysis; D007114:Immunization; D009052:Leukemia Virus, Murine / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D008223:Lymphoma / Q000209:etiology / Q000382:microbiology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D011289:Preleukemia / Q000209:etiology / Q000473:pathology; D013601:T-Lymphocytes / Q000382:microbiology; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D014762:Viral Interference; D014779:Virus Replication
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D006183:H-2 Antigens