title: [Citrate influence on acetyl-CoA-carboxylase activation and phosphorylation in chicken liver with lipogenesis inhibited by nicotinic acid].
abstract: Nicotinic acid in vivo affects the citrate demand for acetyl-CoA-carboxylase activation in the chicken liver under conditions of alimentary lipogenesis stimulation. Stoichiometry of the citrate binding with the dissociation constant of the enzyme-allosteric activator complex is determined under experimental conditions. Endogenic phosphorylation of acetyl-CoA-carboxylase completely correlates with its inactivation and depends on the citrate level. cAMP is established to have an activating effect on phosphorylation of acetyl-CoA-carboxylase of test animals.
authors.forename: A I
authors.initials: AI
authors.lastname: Fomenko
authors.forename: A G
authors.initials: AG
authors.lastname: Khalmuradov
authors.forename: L N
authors.initials: LN
authors.lastname: Khustochka
authors.forename: S V
authors.initials: SV
authors.lastname: Pozharum
authors.forename: S P
authors.initials: SP
authors.lastname: Stepanenko
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000378:metabolism*; D000818:Animals; D002645:Chickens; D002951:Citrates / Q000378:metabolism*; D019343:Citric Acid; D000242:Cyclic AMP / Q000502:physiology; D004789:Enzyme Activation; D008025:Ligases / Q000378:metabolism*; D008055:Lipids / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D009525:Niacin / Q000494:pharmacology*; D010766:Phosphorylation
chemical_list: D002951:Citrates; D008055:Lipids; D009525:Niacin; D019343:Citric Acid; D000242:Cyclic AMP; D008025:Ligases; D000103:Acetyl-CoA Carboxylase
vernacular_title: Vliianie tsitrata na aktivatsiiu i stepen' fosforilirovaniia atsetil CoA-karboksilazy pecheni tsypliat pri ingibirovanii lipogeneza nikotinovoĭ kislotoĭ.