Action of uric acid, allopurinol and oxypurinol on the myeloperoxidase-derived oxidant hypochlorous acid.
Both oxypurinol and uric acid react with the myeloperoxidase-derived oxidant hypochlorous acid at physiological pH, and they can protect the elastase-inhibitory capacity of human alpha 1-antiprotease against inactivation by hypochlorous acid. Allopurinol does not protect alpha 1-antiprotease, possibly because the redox potential of allopurinol at physiological pH is too positive to permit oxidation by hypochlorous acid.
Grootveld
M
M
Department of Biochemistry, King's College (KQC), Strand Campus, London, UK.
Halliwell
B
B
Moorhouse
C P
CP
D000493:Allopurinol; D005609:Free Radicals; D006997:Hypochlorous Acid; D010084:Oxidation-Reduction; D010117:Oxypurinol; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D009195:Peroxidase; D011743:Pyrimidines; D014527:Uric Acid
D005609:Free Radicals; D011743:Pyrimidines; D014527:Uric Acid; D000493:Allopurinol; D006997:Hypochlorous Acid; D009195:Peroxidase; D010196:Pancreatic Elastase; D010117:Oxypurinol