title: [Evaluation of the functional state of the leprous macrophages].
abstract: Cytochrome oxidase (CCO), peroxidase, succinic dehydrogenase (SDG) and NADH-diaphorase were studied electron-cytochemically in leprous macrophages (LM) of granulomas of patients suffering from lepromatous leprosy. The LM peroxidase activity and location differed, this affecting the completeness of M. leprae phagocytosis. High CCO activity in LM cytoplasm was not a factor essentially influencing M. leprae disintegration. SDG and NADH-diaphorase, locating predominantly in membraneous structures of M. leprae, show low activity in LM cytoplasm.
authors.forename: A K
authors.initials: AK
authors.lastname: Maslov
authors.forename: A A
authors.initials: AA
authors.lastname: Iushchenko
mesh_terms: D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D006801:Humans; D007918:Leprosy / Q000276:immunology / Q000378:metabolism*; D008264:Macrophages / Q000201:enzymology / Q000502:physiology* / Q000648:ultrastructure; D010544:Peroxidases / Q000378:metabolism; D010587:Phagocytosis; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D010544:Peroxidases; D013385:Succinate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase; D003576:Electron Transport Complex IV
vernacular_title: Otsenka funktsional'nogo sostoyaniya leproznykh makrofagov.