title: Facilitated transport of sodium salicylate across an artificial lipid membrane by Azone.
abstract: The ability of Azone (1-dodecylazacylcoheptan-2-one), a recently developed penetration enhancer, to facilitate the transport of sodium salicylate across an artificial lipid membrane has been investigated using the rotating diffusion cell, a well defined model for percutaneous absorption. Azone was found to be capable of enhancing the transport of the salicylate anion across an isopropyl myristate membrane, by using a pH gradient as the chemical driving force. The results indicate that Azone may be capable of forming ion pairs with anionic drugs.
authors.forename: J
authors.initials: J
authors.lastname: Hadgraft
authors.forename: K A
authors.initials: KA
authors.lastname: Walters
authors.forename: P K
authors.initials: PK
authors.lastname: Wotton
mesh_terms: D001381:Azepines / Q000032:analysis*; D004058:Diffusion; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000032:analysis*; D008567:Membranes, Artificial; D012459:Salicylates / Q000032:analysis*; D020156:Salicylic Acid
chemical_list: D001381:Azepines; D008055:Lipids; D008567:Membranes, Artificial; D012459:Salicylates; C035229:laurocapram; D020156:Salicylic Acid