Somatostatin's ability to inhibit gastric acid is not prostaglandin-mediated in the dog.
The role of prostaglandins in the effect of somatostatin to inhibit cholinergically stimulated gastric acid output was examined in gastric fistula dogs. Methacholine stimulation of gastric acid output to a maximum of 810 +/- 423 mu eq of [H+] per 15 min was inhibited by 10 nM somatostatin to the same extent either in the presence and/or the absence of indomethacin. In contrast, histamine-induced acid secretion was stimulated weakly by 10 nM somatostatin. Our data do not support a role for prostaglandins in somatostatin's action to inhibit cholinergically stimulated acid secretion.
Gerber
J G
JG
Hughes
M
M
Payne
N A
NA
D000818:Animals; D004285:Dogs; D004347:Drug Interactions; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D008688:Methacholine Compounds / Q000494:pharmacology; D011453:Prostaglandins / Q000502:physiology*; D013004:Somatostatin / Q000494:pharmacology*
D008688:Methacholine Compounds; D011453:Prostaglandins; D013004:Somatostatin; D006632:Histamine; D007213:Indomethacin