title: Knemometric monitoring of early effects of human growth hormone on leg length in children with growth hormone deficiency.
abstract: The early effects of human growth hormone (hGH) were investigated by knemometry, a recently described technique of measuring lower leg length. In 14 growth hormone deficient children, the mean increase in the lower leg length was 0.47 +/- 0.10 (SE) mm within 24 h of a single intramuscular injection of 4 IU hGH. This increase occurred after about 80% of the single injections and was highly significant (p less than 0.01). 48 h after an injection, a slight but not significant reduction of the lower leg length was observed (-0.15 +/- 0.09 [SE]). These effects led to a marked zig-zag pattern of growth when hGH was given thrice weekly.
authors.forename: M
authors.initials: M
authors.lastname: Hermanussen
authors.forename: W G
authors.initials: WG
authors.lastname: Sippell
authors.forename: I M
authors.initials: IM
authors.lastname: Valk
mesh_terms: D000293:Adolescent; D000328:Adult; D001846:Bone Development / Q000187:drug effects; D002648:Child; D005260:Female; D013006:Growth Hormone / Q000172:deficiency* / Q000494:pharmacology; D006801:Humans; D007866:Leg / Q000254:growth & development*; D008297:Male
chemical_list: D013006:Growth Hormone