Effects of alpha-aminoadipic acid on the glutamate-isolated P III of the rabbit electroretinogram.
alpha-Aminoadipic acid was intravitreally applied to adult rabbits. After 5 h, the retinae of these animals were examined by electroretinography and histochemistry. The retinal Müller cells were extremely swollen, and the electroretinographic slow P III was extinguished. The mass receptor potential was somewhat diminished. The results are consistent with the opinion that the slow P III is the reaction of the Müller cells to the changed external potassium ion concentration caused by the activity of the photoreceptors.
Reichenbach
A
A
Wohlrab
F
F
D015074:2-Aminoadipic Acid / Q000494:pharmacology*; D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology*; D000818:Animals; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D004594:Electrophysiology; D004596:Electroretinography; D005971:Glutamates; D018698:Glutamic Acid; D009457:Neuroglia / Q000187:drug effects*; D010786:Photoreceptor Cells / Q000503:physiopathology*; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology
D000600:Amino Acids, Dicarboxylic; D005971:Glutamates; D015074:2-Aminoadipic Acid; D018698:Glutamic Acid; D008058:Dihydrolipoamide Dehydrogenase