title: Iron release from ferritin by alloxan radical.
abstract: Alloxan in the presence of reduced glutathione released iron from ferritin which is the major intracellular iron storage protein. Superoxide dismutase inhibited by only about 30% the alloxan-dependent iron release from ferritin but completely inhibited the iron release from ferritin induced by hypoxanthine-xanthine oxidase. Under anaerobic conditions, the ESR spectrum of alloxan radical was obtained and interaction with ferritin resulted in a marked diminution of the alloxan radical signal. These results indicate that alloxan radical rapidly releases iron from ferritin.
authors.affiliation: Department of Biochemistry, Hokkaido Institute of Pharmaceutical Sciences, Otaru, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miura
authors.forename: K
authors.initials: K
authors.lastname: Sakurai
mesh_terms: D000496:Alloxan / Q000494:pharmacology*; D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D005293:Ferritins / Q000378:metabolism*; D005609:Free Radicals; D005978:Glutathione / Q000494:pharmacology; D007501:Iron / Q000378:metabolism*; D007700:Kinetics; D013482:Superoxide Dismutase / Q000097:blood; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D005609:Free Radicals; D000496:Alloxan; D005293:Ferritins; D007501:Iron; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D005978:Glutathione