Inverse temporal relationship between rate of neurite outgrowth and neurotransmitter function in rat superior cervical ganglion in vitro.
Explanation of the embryonic rat superior cervical ganglion initiated a retrograde response in noradrenergic neurons. By the 4th day of explanation, tyrosine hydroxylase activity per cell decreased to 62% of the day 0 control value. The rate of neurite outgrowth during the same period increased by 66%. By the 6th day both tyrosine hydroxylase activity and rate of neurite outgrowth returned to initial values. This inverse relationship is consistent with a proposed reordering of synthetic priorities that occurs in the parental cell body during axonal regeneration.
Cannella
M S
MS
Ross
R A
RA
D000320:Adrenergic Fibers / Q000378:metabolism / Q000502:physiology; D000818:Animals; D005728:Ganglia, Sympathetic / Q000254:growth & development / Q000378:metabolism*; D009474:Neurons / Q000254:growth & development*; D051381:Rats; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D014446:Tyrosine 3-Monooxygenase