Regional mapping to 4q32.1 by in situ hybridization of a DNA domain rearranged in human liver cancer.
Recently, a unique cellular DNA segment, representing the normal allele counterpart of hepatitis B virus integration site, has been isolated. It has allowed the identification of a cellular domain in which rearrangements occur in approximately 10% of primary liver tumours. We here report on the assignment of this probe, D4S112, by in situ hybridization to band 4q32.1.
Blanquet
V
V
U.173 INSERM-UA.119 CNRS, Hôpital Necker-Enfants-Malades, Paris, France.
Garreau
F
F
Chenivesse
X
X
Brechot
C
C
Turleau
C
C
D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000382:microbiology; D002478:Cells, Cultured; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D004279:DNA, Viral / Q000235:genetics; D015321:Gene Rearrangement; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D008113:Liver Neoplasms / Q000235:genetics* / Q000382:microbiology; D009693:Nucleic Acid Hybridization; D011995:Recombination, Genetic
D004279:DNA, Viral