Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria.
6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine. The 7th patient had taken amodiaquine alone, but at a higher dose. A retrospective analysis suggests that the frequency of severe neutropenia complicating amodiaquine taken prophylactically may be as high as 1 in 2000.
Hatton
C S
CS
Peto
T E
TE
Bunch
C
C
Pasvol
G
G
Russell
S J
SJ
Singer
C R
CR
Edwards
G
G
Winstanley
P
P
D000208:Acute Disease; D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced*; D000655:Amodiaquine / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008288:Malaria / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced*; D002727:Proguanil / Q000008:administration & dosage; D012189:Retrospective Studies; D013414:Sulfaguanidine / Q000008:administration & dosage; D013420:Sulfamethoxazole / Q000008:administration & dosage; D014195:Travel; D014295:Trimethoprim / Q000008:administration & dosage; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D004338:Drug Combinations; D013414:Sulfaguanidine; D000655:Amodiaquine; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole; D002727:Proguanil