Inhibition of [3H] glutamate release from rat hippocampal slices by L-phenylisopropyladenosine.
Hippocampal slices were labelled with [3H]glutamate. Evoked release, which was calcium-dependent and inhibited by tetrodotoxin, could be reduced concentration-dependently by L-PIA. The effect of L-PIA was blocked by 10 microM 8-phenyltheophylline. The results indicate that there are adenosine receptors modulating the efflux of glutamate in field stimulated hippocampal slices.
Fastbom
J
J
Fredholm
B B
BB
D000241:Adenosine / Q000031:analogs & derivatives*; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D010660:Phenylisopropyladenosine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013779:Tetrodotoxin / Q000494:pharmacology; D013806:Theophylline / Q000031:analogs & derivatives / Q000494:pharmacology
D005971:Glutamates; D010660:Phenylisopropyladenosine; D018698:Glutamic Acid; D013779:Tetrodotoxin; D013806:Theophylline; C028322:8-phenyltheophylline; D000241:Adenosine; D002118:Calcium