title: Nature, incidence and prognosis of neurological involvement in the acquired immunodeficiency syndrome in central London.
abstract: Clinical neurological involvement at various times throughout the illness was recorded in 52% of 122 patients seen in central London who died from acquired immunodeficiency syndrome (AIDS). Various metabolic encephalopathies, dementias, focal encephalopathies, retinopathies and peripheral nerve pathology were the most frequent manifestations. Seven of 9 patients with a neurological presentation had no other major systemic illness. The median time from diagnosis of AIDS to death was 9 months and from onset of neurological symptoms to death 4 months. Human immunodeficiency virus dementia, central nervous system opportunistic infections, presence of Kaposi sarcoma, neurological presentations and minor symptoms were not associated with major change in survival time.
authors.affiliation: Department of Neurology, St Stephen's Hospital, London, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Guiloff
authors.forename: G N
authors.initials: GN
authors.lastname: Fuller
authors.forename: A
authors.initials: A
authors.lastname: Roberts
authors.forename: M
authors.initials: M
authors.lastname: Hargreaves
authors.forename: B
authors.initials: B
authors.lastname: Gazzard
authors.forename: F
authors.initials: F
authors.lastname: Scaravilli
authors.forename: J N
authors.initials: JN
authors.lastname: Harcourt-Webster
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001927:Brain Diseases / Q000209:etiology; D003704:Dementia / Q000209:etiology; D006801:Humans; D008131:London; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology*; D010523:Peripheral Nervous System Diseases / Q000209:etiology; D011379:Prognosis; D012164:Retinal Diseases / Q000209:etiology; D013997:Time Factors