The importance of bradykinin and histamine in the skin response to antigen.
On three separate occasions 12 atopic subjects were injected intradermally with two doses of antigen and one of saline as control. Pretreatment with terfenadine 60 mg orally significantly inhibited the flare response to both the lower dose of antigen and to saline (P less than 0.05). Ingestion of enalapril 5 mg orally 3 h before increased the flare response to both doses of antigen. Neither enalapril nor terfenadine affected the weal response when compared with placebo. Both endogenous histamine and bradykinin appear to be released during the intradermal flare response but are not important in the weal reaction to antigen.
Warren
J B
JB
Department of Clinical Pharmacology, Royal Postgraduate Medical School, London.
Newman
C M
CM
Pixley
F J
FJ
Fuller
R W
RW
Dollery
C T
CT
D000328:Adult; D000818:Animals; D000941:Antigens / Q000502:physiology*; D001559:Benzhydryl Compounds / Q000494:pharmacology; D001920:Bradykinin / Q000502:physiology*; D003877:Dermatitis, Contact / Q000276:immunology / Q000503:physiopathology; D004656:Enalapril / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000502:physiology*; D006801:Humans; D008297:Male; D008925:Mites / Q000276:immunology; D011058:Pollen / Q000037:antagonists & inhibitors; D012867:Skin / Q000276:immunology; D012879:Skin Physiological Phenomena; D016593:Terfenadine
D000941:Antigens; D001559:Benzhydryl Compounds; D004656:Enalapril; D016593:Terfenadine; D006632:Histamine; D001920:Bradykinin