[Ca2+ participation in vasodilator reactions].
Stimulation of alpha-adrenoceptors was simulated by intraarterial injection of 0.6 mmol CaCl2 in acute experiments on resting muscles of the dog hind leg. It has been demonstrated that alpha-adrenergic stimulation of metabolism in skeletal muscles has a vasodilative effect in the muscle-supplying vessels. It has been also shown that imitation of alpha-adrenergic stimulation effect by intraarterial injection of CaCl2 causes Ca- and alpha-adrenergic-dependent vasodilative reactions. It is suggested that disturbance of vasodilative effects caused by alpha-adrenergic stimulation in the effector tissues, counteracting the direct constrictive alpha-adrenoceptor effect in the smooth muscle cells of the vessel wall, can lead to systemic impairment of the vascular tone.
Lysenko
L T
LT
Kirishchuk
S I
SI
Kostenko
T O
TO
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000502:physiology*; D002122:Calcium Chloride / Q000494:pharmacology; D004285:Dogs; D005263:Femoral Artery / Q000187:drug effects / Q000502:physiology*; D006439:Hemodynamics / Q000187:drug effects; D006940:Hyperemia / Q000139:chemically induced / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D011942:Receptors, Adrenergic, alpha; D002122:Calcium Chloride; D010100:Oxygen; D002118:Calcium
Uchastie Ca2+ v sosudorasshiritel'nykh reaktsiiakh.