[C-2 basically substituted thiazoles with H2-antagonistic action. 21. H2-antihistaminics].
In studies on structure-activity relationships of histamine H2-receptor antagonists, C-2 basically substituted thiazoles were prepared and tested for their H2-antihistaminic activity on the isolated guinea-pig atrium and on the histamine stimulated acid secretion of the anaesthetized rat. As a basic substituent the dimethylaminomethyl group is especially suitable, while cyclic guanidines lead to lower H2-antagonistic activity.
Trumm
K A
KA
Sattler
H J
HJ
Postius
S
S
Szelenyi
I
I
Schunack
W
W
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004558:Electric Stimulation; D005744:Gastric Acid / Q000378:metabolism; D006168:Guinea Pigs; D006635:Histamine H2 Antagonists / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013844:Thiazoles / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology
D006635:Histamine H2 Antagonists; D013844:Thiazoles
C-2 Basisch substituierte Thiazole mit H2-antagonistischer Wirkung 21. Mitt.: H2-Antihistaminika.