title: Different patterns of molecular forms of somatostatin are released by the rat median eminence and hypothalamus.
abstract: The molecular forms of somatostatin (SOM) released from hypothalamic slices and from the isolated median eminence (ME) in vitro were compared by high-performance liquid chromatography and radioimmunoassay. SOM-14 was the predominant form of the peptide released from hypothalamic slices, although small amounts of SOM-28 were detected. Perifusates of ME tissue contained a larger proportion of SOM-28 and higher molecular weight peptides were present; depolarization increased the rates of release of all molecular forms of SOM. These results suggest that the capacity to release SOM-28 and high-molecular-weight forms of SOM may be a specialized function of nerve terminals in the ME.
authors.forename: A R
authors.initials: AR
authors.lastname: Pierotti
authors.forename: A J
authors.initials: AJ
authors.lastname: Harmar
authors.forename: L A
authors.initials: LA
authors.lastname: Tannahill
authors.forename: G W
authors.initials: GW
authors.lastname: Arbuthnott
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology; D007031:Hypothalamus / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008473:Median Eminence / Q000378:metabolism; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000378:metabolism*; D053561:Somatostatin-28
chemical_list: D013004:Somatostatin; D053561:Somatostatin-28; D011188:Potassium; D002118:Calcium