[Effect of immunomodulators on resistance to gas gangrene. The enhanced resistance of white mice to perfringens toxin type A as affected by prodigiozan].
Experiments on 575 noninbred white mice have revealed that the nonspecific resistance of the animals to type A C. perfringens toxin can be enhanced by the administration of Prodigiosan, a commercial immunostimulating agent. Prodigiosan, introduced in 3-4 injections (the last one made 24 hours before intoxication) has been found to enhance the resistance of the animals to the subcutaneous injection of type A C. perfringens toxin by 40-60% and to its intraperitoneal injection by 60-97%.
Konikova
R E
RE
Stepanov
A V
AV
Sviridov
L P
LP
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001427:Bacterial Toxins / Q000037:antagonists & inhibitors / Q000276:immunology*; D002135:Calcium-Binding Proteins; D003016:Clostridium perfringens; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D005738:Gas Gangrene / Q000188:drug therapy / Q000276:immunology* / Q000401:mortality; D007113:Immunity, Innate / Q000187:drug effects; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D011354:Prodigiozan / Q000627:therapeutic use*; D013997:Time Factors; D010738:Type C Phospholipases
D000276:Adjuvants, Immunologic; D001427:Bacterial Toxins; D002135:Calcium-Binding Proteins; D011135:Polysaccharides, Bacterial; D011354:Prodigiozan; D010738:Type C Phospholipases; C040649:alpha toxin, Clostridium perfringens
Izuchenie vliianiia immunomoduliatorov na ustoĭchivost' organizma k agzovoĭ gangrene. Povyshenie ustoĭchivosti belykh mysheĭ k toksinu perfringens tipa A pod vliianiem prodigiozana.