[The effect of verdazyl radicals on Ca2+ metabolism in preparations of heavy sarcoplasmic reticulum].
Three verdazyl radicals were studied for their effect on calcium accumulation and outflux (passive and Ca- or caffeine-induced) and conformational state of the Ca-ATPase. All three compounds differently affected the ATP-dependent Ca-accumulation. Their effect on the Ca-release from the sarcoplasmic reticulum vesicles could not be explained by their influence on the Ca-accumulation system. The Ca2+ amount liberated by the calcium or caffeine addition was equal in both cases but was modified differently by the used verdazyl compounds. The data obtained suggest that Ca-induced and caffeine-induced calcium release is realized by different mechanisms.
Uspanova
Zh K
ZhK
Rubtsov
A M
AM
Vigalok
I V
IV
Boldyrev
A A
AA
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D005609:Free Radicals; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000378:metabolism
D015220:Calcium Channels; D005609:Free Radicals; D006571:Heterocyclic Compounds; D013438:Sulfhydryl Compounds; C057662:6-(4-methoxyphenyl)-2,4-diphenylverdazyl; C057661:2,4,6-triphenylverdazyl; C057663:6-(4-nitrophenyl)-2,4-diphenylverdazyl; D002110:Caffeine; D000252:Calcium-Transporting ATPases; D002118:Calcium
Vliianie verdazil'nykh radikalov na obmen Ca2+ v preparatakh tiazhelogo sarkoplazmaticheskogo retikuluma.