title: A repeat sequence, GGGTTA, is shared by DNA of human herpesvirus 6 and Marek's disease virus.
abstract: Some regions of the genomes of human B-lymphotrophic virus (HBLV), also designated as human herpesvirus 6, and Marek's disease virus were found to hybridize to each other under moderate to stringent conditions, scoring from 10 to 30% base-pair mismatch. Nucleotide sequence analysis showed that a 6-base-pair repetitive sequence, GGGTTA (DR2), present in the IRS-IRL junction region of the Marek's disease virus genome, was also reiterated in the HBLV genome. The function(s) of such a sequence is unknown, but this is the first report of homology between HBLV and a nonhuman herpesvirus.
authors.affiliation: Department of Virology, Showa University Research Institute for Biomedicine in Florida, St. Petersburg 33716.
authors.forename: M
authors.initials: M
authors.lastname: Kishi
authors.forename: H
authors.initials: H
authors.lastname: Harada
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: A
authors.initials: A
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: M
authors.initials: M
authors.lastname: Nonoyama
authors.forename: S F
authors.initials: SF
authors.lastname: Josephs
authors.forename: A
authors.initials: A
authors.lastname: Buchbinder
authors.forename: F
authors.initials: F
authors.lastname: Schachter
authors.forename: D V
authors.initials: DV
authors.lastname: Ablashi
mesh_terms: D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D003429:Cross Reactions; D015342:DNA Probes; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000235:genetics*; D015245:Deoxyribonuclease BamHI; D006564:Herpesviridae / Q000235:genetics*; D008381:Herpesvirus 2, Gallid / Q000235:genetics*; D006801:Humans; D009693:Nucleic Acid Hybridization; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D015342:DNA Probes; D004279:DNA, Viral; D004262:DNA Restriction Enzymes; D015245:Deoxyribonuclease BamHI