Cobalt-dependent stimulation of sodium transport in the amphibian skin and nephron.
One to ten millimolar CoCl2, when applied to the outer surface of the apical membrane of the frog skin (Rana temporaria), reversibly increased the potential differences and short-circuit current. These observations suggest that Co2+ may control the gating system of the sodium channel. In the kidney of the newt (Triturus vulgaris), proximal reabsorption is increased under the influence of 0.5 mM CoCl2 injected into the lumen. When CoCl2 (0.5 mM) was injected into the lumen of the distal tubule of the newt kidney, Na+ and Cl- reabsorption was stimulated simultaneously Ca2+ transport was inhibited. The data obtained suggested that Co2+ may affect the state of the sodium and calcium channels of nonexcitable membranes of amphibia, and thus may be involved in the regulation of the function of the renal tubules.
Natochin YuV
Goncharevskaya
O A
OA
Monin YuG
D000818:Animals; D003035:Cobalt / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009399:Nephrons / Q000187:drug effects / Q000502:physiology*; D009928:Organ Specificity; D011896:Rana temporaria; D012867:Skin / Q000187:drug effects; D012879:Skin Physiological Phenomena; D012964:Sodium / Q000378:metabolism*; D013045:Species Specificity; D014319:Triturus
D003035:Cobalt; D012964:Sodium; C018021:cobaltous chloride