title: Peripheral dopamine receptor blockade by SCH 23390 and domperidone in vitro.
abstract: The antagonist potencies of SCH 23390 and domperidone have been determined at vascular and neuronal dopamine receptors in the rabbit isolated splenic artery and rectococcygeus muscle, respectively. SCH 23390 was a potent, competitive antagonist at vascular (pA2 = 10.65) but not neuronal (pA2 less than 6.0) receptors. Domperidone was a potent, competitive antagonist at neuronal (pA2 = 7.9) but not vascular (pA2 less than 4.0) receptors. SCH 23390 and domperidone are, therefore, highly selective vascular and neuronal dopamine receptor antagonists respectively.
authors.forename: A
authors.initials: A
authors.lastname: Hilditch
authors.forename: G M
authors.initials: GM
authors.lastname: Drew
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001158:Arteries / Q000187:drug effects; D001552:Benzazepines / Q000494:pharmacology*; D015237:Dinoprost; D004294:Domperidone / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D010643:Phenoxybenzamine / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011817:Rabbits; D011954:Receptors, Dopamine / Q000187:drug effects*
chemical_list: D014150:Antipsychotic Agents; D001552:Benzazepines; D011460:Prostaglandins F; D011954:Receptors, Dopamine; D010643:Phenoxybenzamine; D004294:Domperidone; D015237:Dinoprost