title: Alternative method for calculating right ventricular ejection fraction from first-pass time-activity curves.
abstract: Single-beat right ventricular ejection fraction (RVEF) determined using the first-pass method changes with rapid variations in the concentration of radionuclide tracer in the ventricle. Underestimation of single-beat RVEF occurs when radionuclide tracer rapidly enters the ventricle, and overestimation results when the tracer quickly flows out of the ventricle. In order to attenuate this effect, a data processing technique employing the relative "time-volume" curve was proposed. In the present paper, it was assumed that this time-volume curve could be approximated by dividing the original time-activity curve by a gamma variate function representing the time-concentration curve. Each single-beat ejection fraction calculated from the time-volume curve agreed well with the known phantom ejection fraction although the concentration of tracer varied rapidly. This new method was applied to several clinical cases.
authors.affiliation: Department of Oncoradiology, Nara Medical University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Iwata
mesh_terms: D006321:Heart / Q000000981:diagnostic imaging* / Q000502:physiology; D006801:Humans; D008722:Methods; D008961:Models, Structural; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D013318:Stroke Volume
chemical_list: D013670:Sodium Pertechnetate Tc 99m