Potent induction of human placental mono-oxygenase activity by previous dietary exposure to polychlorinated biphenyls and their thermal degradation products.
Placental tissues were obtained from women in Taiwan who had ingested rice oil contaminated with aromatic polychlorinated hydrocarbons 3-4 years before conception. Known contaminants in the rice oil were polychlorinated biphenyls and their thermal degradation products, including polychlorinated dibenzofurans and polychlorinated quaterphenyls. Placental homogenates showed large increases in mono-oxygenase enzymes, including aryl hydrocarbon hydroxylase, 7-ethoxycoumarin O-de-ethylase, and diol, quinone, and phenolic metabolites of benzo(a)pyrene (analysed by high performance liquid chromatography). The findings suggest that exposure to these widespread, environmental pollutants may exert substantial and persistent metabolic effects.
Wong
T K
TK
Everson
R B
RB
Hsu
S T
ST
D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D001564:Benzo(a)pyrene / Q000378:metabolism; D002681:China; D004790:Enzyme Induction; D005260:Female; D005506:Food Contamination; D006801:Humans; D007231:Infant, Newborn; D010105:Oxygenases / Q000378:metabolism*; D010920:Placenta / Q000201:enzymology* / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000378:metabolism / Q000506:poisoning*; D011247:Pregnancy; D012907:Smoking; D013997:Time Factors
D001564:Benzo(a)pyrene; D011078:Polychlorinated Biphenyls; D010105:Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases