title: Immunological activities of multiprenylacetyl derivatives of muramyldipeptides.
abstract: The immunological properties of six kinds of multiprenylacetic acids and six kinds of multiprenylacetyl muramyldipeptide (MDP) derivatives were examined by using experimental models in mice and guinea-pigs. All the multiprenylacetyl MDP derivatives, particularly TMD-232, showed potent adjuvant activity on the circulating antibody formation against bacterial alpha-amylase in mice, and induction of delayed-type hypersensitivity to monoazobenzenearsonate N-acetyl-L-tyrosine in guinea-pigs. All multiprenylacetic acid preparations tested in this study, however, showed no adjuvant activity in these immune systems. Both TMD-17 and TMD-232 entrapped into multilamellar vesicles showed potent host stimulation activity against Sendai virus infection in mice.
authors.affiliation: Institute of Immunological Science, Hokkaido University, Sapporo, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Azuma
authors.forename: I
authors.initials: I
authors.lastname: Saiki
authors.forename: J
authors.initials: J
authors.lastname: Iida
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives / Q000276:immunology*; D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D008297:Male; D051379:Mice; D018184:Paramyxoviridae Infections / Q000276:immunology; D014443:Tyrosine / Q000031:analogs & derivatives / Q000276:immunology; D000516:alpha-Amylases / Q000276:immunology; D010132:p-Azobenzenearsonate / Q000031:analogs & derivatives / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; C000234:azobenzenearsonate-N-acetyl-L-tyrosine; D014443:Tyrosine; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D010132:p-Azobenzenearsonate; D000516:alpha-Amylases