Solubility of diazepam and prazepam in aqueous non-ionic surfactants.
The solubility of diazepam and prazepam in aqueous polyoxyethylen-10-dodecanol, polyoxyethylen-23-dodecanol and polyoxyethylen-20-hexadecanol, has been determined at 25.0 degrees C. Diazepam seems to achieve a higher micellar penetration than prazepam, in spite of an expected smaller hydrophobic character. Thermodynamic interpretation of the micellar solutions is carried out using the regular solutions approach. A surfactant-independent relation between solubilities of both drugs has been derived.
Moro
M E
ME
Velazquez
M M
MM
Cachaza
J M
JM
Rodriguez
L J
LJ
D003975:Diazepam; D008823:Micelles; D011092:Polyethylene Glycols; D011222:Prazepam; D012995:Solubility; D013816:Thermodynamics
D008823:Micelles; D011092:Polyethylene Glycols; D011222:Prazepam; D003975:Diazepam