The effect of dexamethasone on plasma glucose and liver glycogen levels in premetamorphic Rana catesbeiana tadpoles and frogs.
Premetamorphic Rana catesbeiana tadpoles and adult frogs demonstrate significant elevations in plasma glucose levels following dexamethasone (dex) injections. This response is greatest in the tadpole 24 hr after dex administration and is still detectable at 48 hr. Liver glycogen levels increase in the frog, but not in the tadpole, following daily injections of dex for five consecutive days. The response of the tadpole to dex occurs at a time when hepatic cytosolic glucocorticoid receptors have been observed, but when endogenous corticosterone is absent.
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D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology*; D007814:Larva; D008112:Liver Glycogen / Q000378:metabolism*; D008675:Metamorphosis, Biological; D011892:Rana catesbeiana / Q000097:blood / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000502:physiology; D013997:Time Factors; D014284:Triiodothyronine / Q000494:pharmacology
D001786:Blood Glucose; D008112:Liver Glycogen; D011965:Receptors, Glucocorticoid; D014284:Triiodothyronine; D003907:Dexamethasone