Effect of serotonin on pentagastrin-stimulated gastric pepsin secretion in dogs with gastric fistula.
The effect of serotonin on pentagastrin-stimulated gastric pepsin secretion in dogs was evaluated with regard to dose-response kinetics and receptor mediation. The pepsin secretion showed a dual response to exogenous serotonin. The high and low doses of serotonin stimulated, whereas the doses in between inhibited. The inhibition was of a non-competitive type and could be significantly counteracted by beta-adrenergic blocking drugs. This study supports the concept that the serotonin effect on gastric functions is mediated via sympathetic nerves releasing noradrenaline.
Bech
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Andersen
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D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005747:Gastric Fistula / Q000503:physiopathology; D005750:Gastric Juice / Q000032:analysis; D007213:Indomethacin / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D010434:Pepsin A / Q000032:analysis / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012701:Serotonin; D010434:Pepsin A; D010418:Pentagastrin; D007213:Indomethacin