Alpha 1-adrenergic responsiveness of young adult and aged rat submandibular cells in vitro.
The present study has evaluated, in vitro, alpha 1-adrenergic receptor mediated responses in submandibular cells from young adult and aged rats. Submandibular glands from different aged rats possess a similar number of alpha 1-adrenergic receptors that display comparable binding characteristics. Following alpha 1-adrenergic stimulation, cells from both groups of rats show a similar ability to mobilize intracellular Ca2+ (45Ca2+ time course, agonist dose-response) and to elicit a functional response (inhibition of protein synthesis by epinephrine) which reflects Ca2+ mobilization.
Baum
B J
BJ
Kuyatt
B L
BL
Helman
Y
Y
Gee
M V
MV
Roth
G S
GS
D000375:Aging; D000818:Animals; D002118:Calcium / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D011224:Prazosin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D013363:Submandibular Gland / Q000187:drug effects / Q000254:growth & development*
D011942:Receptors, Adrenergic, alpha; D002118:Calcium; D011224:Prazosin; D004837:Epinephrine