title: [Hismanal--a non-sedating H1 antihistaminic].
abstract: The intake of antihistamines with CNS depressing side effects leads to a multiple increase of risk for accidents with lethal results in traffic. 12 special pharmacopsychological trials, e.g. at the Royal Air Force Institut, Great Britain; at the Association for Research into Accident Causes, Cologne; and the Department of Pharmacotherapy (Drugs and Driving Research Group), University of Utrecht, Netherlands, showed Hismanal to have neither sedation nor performance reducing side effects.
authors.forename: W
authors.initials: W
authors.lastname: Karrass
mesh_terms: D001143:Arousal / Q000187:drug effects*; D016589:Astemizole; D001334:Automobile Driving; D001562:Benzimidazoles / Q000009:adverse effects / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D006634:Histamine H1 Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy*; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D014792:Visual Acuity / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects
chemical_list: D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D016589:Astemizole
vernacular_title: Hismanal--Ein sedierungsfreies H1-Antihistaminikum.