Effects of Ca-antagonists and antispasmodic drugs on contraction by ACh in molluscan smooth muscle.
The influence of Ca-antagonists and antispasmodic drugs on contractions by ACh and by DMPP were investigated. Verapamil (10(-5) to 10(-4) M), diltiazem (10(-5) to 10(-4) M) and D-600 (10(-5) to 10(-4) M) depressed both the contractions in a dose dependent manner. Papaverine (10(-5) to 10(-4) M) and Aspaminol (10(-6) to 10(-5) M) also depressed both the contractions in a dose dependent manner. These findings indicate that Ca2+, which initiates the contraction by ACh, is supplied from both the external medium and intracellular store sites.
Murakami
H
H
Ishikawa
T
T
Watanabe
H
H
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D049872:Bivalvia / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004110:Diltiazem / Q000494:pharmacology; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology; D004347:Drug Interactions; D005711:Gallopamil / Q000494:pharmacology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010208:Papaverine / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D010276:Parasympatholytics; D010880:Piperidines; D005711:Gallopamil; D004246:Dimethylphenylpiperazinium Iodide; D014700:Verapamil; D010208:Papaverine; D004110:Diltiazem; D000109:Acetylcholine