Natural killing of fibroblasts infected with low-passage clinical isolates of human cytomegalovirus.
Fibroblasts infected with most low-passage clinical isolates of human cytomegalovirus (CMV) were as susceptible to lysis by human natural killer (NK) cells as high passage AD-169-infected fibroblasts. NK lysis occurred despite the absence of detectable CMV-specific late membrane antigen(s) on the majority of the target cells infected with most of the low passage strains. The magnitude of NK lysis of different CMV-infected target cells did not correlate with their ability to induce IFN-alpha. NK cell-mediated lysis of cells infected with low-passage clinical isolates of CMV required both NK cells and HLA-DR+ accessory cells, as previously shown for AD-169-infected target cells.
Bandyopadhyay
S
S
Department of Pediatrics, Joseph Stokes Jr. Research Institute, Children's Hospital of Philadelphia, Pennsylvania.
Oh
S H
SH
Michelson
S
S
Miller
D S
DS
Virelizier
J L
JL
Starr
S E
SE
D000938:Antigen-Presenting Cells / Q000276:immunology; D000956:Antigens, Viral / Q000032:analysis; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005347:Fibroblasts / Q000276:immunology; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology*
D000956:Antigens, Viral; D007370:Interferon Type I