title: Functions of the DnaA protein of Escherichia coli in replication and transcription.
abstract: The function of DnaA protein as a replisome organizer in the initiation of DNA replication is reviewed. A model is presented showing the construction of two basic types of DnaA-dependent replication origin. New data demonstrate that the dnaA box-DnaA protein complex is a transcription terminator. Only one orientation of the dnaA box results in termination of transcription. Mutation of the dnaA box within the dnaA reading frame shows that DnaA-mediated transcription termination has a role in the autoregulation of the dnaA gene.
authors.affiliation: Max-Planck-Institut für molekulare Genetik, Berlin, F.R.G.
authors.forename: W
authors.initials: W
authors.lastname: Messer
authors.forename: W
authors.initials: W
authors.lastname: Seufert
authors.forename: C
authors.initials: C
authors.lastname: Schaefer
authors.forename: A
authors.initials: A
authors.lastname: Gielow
authors.forename: H
authors.initials: H
authors.lastname: Hartmann
authors.forename: M
authors.initials: M
authors.lastname: Wende
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000502:physiology*; D001483:Base Sequence; D004261:DNA Replication; D004926:Escherichia coli; D008969:Molecular Sequence Data; D012097:Repressor Proteins; D014157:Transcription Factors; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; D012097:Repressor Proteins; D014157:Transcription Factors