[Unusual abdominal apudomas. I. Cushing syndrome in association with Zollinger-Ellison syndrome in an endocrine pancreas tumor].
Ectopic production of ACTH is observed in 6% of patients with Cushing syndrome. Ten percent of these cases are related to endocrine pancreatic tumors. In a few cases a multiplicity of hormones are produced. The combination with a Zollinger-Ellison syndrome is very infrequent. In the present case, a female patient aged 54, there was an interval between the onset of Zollinger-Ellison and Cushing syndrome. The combination of bilaterally enlarged adrenals in the absence of an adrenal adenoma and the presence of Crooke-cells in the adenohypophysis in a patient with Cushing syndrome are of diagnostic significance. This trias should always alert the physician to the possibility of extrahypophyseal ACTH production.
Gottschalk
J
J
Buntrock
P
P
Gerl
H
H
Knappe
G
G
Rohde
W
W
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D001079:Apudoma / Q000150:complications*; D001344:Autopsy; D003480:Cushing Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000150:complications* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000473:pathology; D015043:Zollinger-Ellison Syndrome / Q000150:complications* / Q000473:pathology
D000324:Adrenocorticotropic Hormone
Ungewöhnliche abdominelle Apudome. I. Mitteilung: Cushing-Syndrom in Kombination mit Zollinger-Ellison-Syndrom bei endokrinem Pankreastumor.