[Changes in the sensitivity of the alpha 2- and beta 1-adrenoreactive systems during the intensive cooling of rats acclimatized to cold].
Cold-acclimated rats with an increased resistance against intensive cold, differ from ordinary animals by increased beta 1- and decreased alpha 2-adrenoreactivity in ordinary conditions; their beta 1-adrenoreactive systems preserve sensitivity at intensive cold exposure (up to hypothermia below 25 degrees C), whereas the sensitivity of their alpha 2-adrenoreactive systems declines more rapidly (up to a moderate hypothermia--33-34 degrees C). The data obtained suggest the described shifts to be important for essential increase in general resistance against acute intensive cold exposure in rats.
Kulinskiĭ
V I
VI
Gertsov
G E
GE
Plotnikov
N Iu
NIu
Bezachev
V G
VG
D000064:Acclimatization / Q000187:drug effects; D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D003080:Cold Temperature / Q000009:adverse effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007035:Hypothermia / Q000503:physiopathology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol; D003000:Clonidine; D011224:Prazosin; D010646:Phentolamine
Izmeneniia chuvstvitel'nosti al'fa 2- i beta 1-adrenoreaktivnykh sistem pri intensivnom okhlazhdenii akklimirovannykh k kholodu krys.