Defective jejunal brush-border Na+/H+ exchange: a cause of congenital secretory diarrhoea.
In a child with congenital secretory diarrhoea, jejunal perfusion studies showed net water and electrolyte secretion and suggested a defect in sodium/proton exchange. A technique was developed for investigation of such exchange in brush-border membrane vesicles from jejunal biopsy specimens. Vesicles from control specimens displayed proton-gradient-dependent sodium uptake, whereas those from the patient did not. These findings, as well as pointing to a cause of congenital secretory diarrhoea, confirm the existence and importance of jejunal sodium/proton exchange in man.
Booth
I W
IW
Stange
G
G
Murer
H
H
Fenton
T R
TR
Milla
P J
PJ
D002462:Cell Membrane / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000151:congenital / Q000378:metabolism*; D005260:Female; D006801:Humans; D006859:Hydrogen / Q000378:metabolism*; D007223:Infant; D007231:Infant, Newborn; D007583:Jejunum / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
D006859:Hydrogen; D012964:Sodium