title: Flumezapine and zotepine: 5-hydroxytryptamine antagonism not involved in the lack of synergism of these antipsychotic drugs with amfonelic acid in rats.
abstract: Two antipsychotic drugs, flumezapine and zotepine, resembled clozapine, not spiperone, in not acting synergistically with amfonelic acid to elevate striatal concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC) in rats. Since flumezapine, zotepine and clozapine antagonize 5-hydroxytryptamine (5-HT) receptors with potency similar to their potency in antagonizing dopamine receptors, the possibility that 5-HT receptor blockade prevented their synergism with amfonelic acid was considered. Methiothepin, a potent 5-HT antagonist and dopamine antagonist, mimicked spiperone in causing a marked increase in striatal DOPAC in amfonelic acid-treated rats, indicating that 5-HT antagonism is not involved in the lack of synergism of flumezapine and zotepine with amfonelic acid.
authors.forename: R W
authors.initials: RW
authors.lastname: Fuller
authors.forename: H D
authors.initials: HD
authors.lastname: Snoddy
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism; D003988:Dibenzothiepins / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D009268:Nalidixic Acid / Q000031:analogs & derivatives; D009287:Naphthyridines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists / Q000494:pharmacology*
chemical_list: D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D003988:Dibenzothiepins; D009287:Naphthyridines; D012702:Serotonin Antagonists; D015102:3,4-Dihydroxyphenylacetic Acid; D001569:Benzodiazepines; D009268:Nalidixic Acid; C045983:flumezapine; C006486:amfonelic acid; C022172:zotepine