title: Elevated lactate dehydrogenase isoenzyme 1 as a tumour marker in patients with germ cell testicular tumours.
abstract: In a series of 50 patients with testicular tumours evaluated prior to orchidectomy, 12 out of 19 with pure seminoma and seven out of 31 with non-seminomatous or mixed seminomatous and non-seminomatous germ cell tumours had elevated plasma lactate dehydrogenase isoenzyme 1 concentrations. In contrast, seven of the 19 seminoma patients had elevated serum human chorionic gonadotrophin (hCG) concentrations and 25 of the 31 non-seminomatous and mixed seminomatous and non-seminomatous germ cell tumour patients had elevations of hCG and/or alpha-fetoprotein. Using these three markers, 12 out of 19 seminoma patients and 27 out of 31 non-seminomatous or mixed seminomatous and non-seminomatous tumour patients were positive for one or more of these tumour markers.
authors.affiliation: Department of Surgery, University of Queensland, Herston, Australia.
authors.forename: D C
authors.initials: DC
authors.lastname: Winkle
authors.forename: A E
authors.initials: AE
authors.lastname: Clague
authors.forename: R A
authors.initials: RA
authors.lastname: Gardiner
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D004407:Dysgerminoma / Q000201:enzymology*; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000201:enzymology*; D009919:Orchiectomy; D013736:Testicular Neoplasms / Q000201:enzymology*
chemical_list: D014408:Biomarkers, Tumor; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase