Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse.
The gene for insulin-like growth factor II (IGF-II) receptor (IGF2R) that has recently been found, by DNA sequencing, to be identical to the cation-independent mannose 6-phosphate receptor (CIM6PR) has been mapped in the human and murine species. Cloned cDNAs for human and rat IGF-II receptors were used to probe Southern blots of somatic cell hybrid DNA and for in situ chromosomal hybridization. The genes are located in a region of other conserved syntenic genes on the long arm of human chromosome 6, region 6q25----q27, and mouse chromosome 17, region A-C. The CIM6PR/IGF2R locus in man is asyntenic with the genes encoding IGF-II (IGF2), the IGF-I receptor (IGF1R), and the cation-dependent mannose 6-phosphate receptor (CDM6PR).
Laureys
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G
Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510.
Barton
D E
DE
Ullrich
A
A
Francke
U
U
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D005796:Genes; D006600:Hexosephosphates / Q000378:metabolism*; D006801:Humans; D006822:Hybrid Cells / Q000166:cytology; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008360:Mannosephosphates / Q000378:metabolism*; D051379:Mice; D009693:Nucleic Acid Hybridization; D017527:Receptor, IGF Type 2; D011956:Receptors, Cell Surface / Q000235:genetics*; D017451:Receptors, Somatomedin; D013002:Somatomedins / Q000378:metabolism*; D013045:Species Specificity
D006600:Hexosephosphates; D008360:Mannosephosphates; D017527:Receptor, IGF Type 2; D011956:Receptors, Cell Surface; D017451:Receptors, Somatomedin; D013002:Somatomedins; D007335:Insulin-Like Growth Factor II