Crohn's disease with persistence of Clostridium difficile, surgical elimination.
Clostridium difficile has been associated with increased activity of Crohn's disease in some patients, and in them its eradication has proved beneficial. We have seen a patient unresponsive to two courses of vancomycin with persistence of C. difficile colonization and toxin production in whom surgical intervention eliminated the C. difficile cytotoxin and organism.
DeRidder
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PH
Kadro
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D000293:Adolescent; D003013:Clostridium / Q000187:drug effects; D003424:Crohn Disease / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery*; D003603:Cytotoxins / Q000096:biosynthesis; D004352:Drug Resistance, Microbial; D006801:Humans; D008297:Male; D011241:Prednisone / Q000494:pharmacology / Q000627:therapeutic use; D012460:Sulfasalazine / Q000494:pharmacology / Q000627:therapeutic use; D014640:Vancomycin / Q000494:pharmacology / Q000627:therapeutic use
D003603:Cytotoxins; D012460:Sulfasalazine; D014640:Vancomycin; D011241:Prednisone