Interactions of ethanol with benzodiazepine receptor ligands in tests of exploration, locomotion and anxiety.
The ability of benzodiazepine receptor ligands to modify the behavioral effects of ethanol in tests of exploration, locomotion and anxiety are reviewed. Drugs with inverse agonist activity appear capable of consistently antagonizing the reductions in exploration and anxiety caused by ethanol. In contrast, the locomotor stimulant action of ethanol has appeared relatively insensitive to inverse agonists, suggesting that this effect may not be mediated primarily by an action of ethanol at the benzodiazepine/GABA receptor complex.
Lister
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Laboratory of Clinical Studies, NIAAA, Bethesda, MD 20892.
D000818:Animals; D001007:Anxiety / Q000139:chemically induced*; D001569:Benzodiazepines / Q000037:antagonists & inhibitors*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects*; D015201:Meta-Analysis as Topic; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology
D011963:Receptors, GABA-A; D001569:Benzodiazepines; D000431:Ethanol