Effect of diet restriction on 24-hr urinary C-peptide excretion in non-insulin-dependent non-obese diabetic subjects.
Changes in insulin secretory responses by diet restriction were analyzed in non-insulin-dependent non-obese diabetic subjects (NIDDM-NO) as well as in healthy volunteers by determining 24-hr urinary C-peptide immunoreactivity (24-hr UCPR). Insulin sensitivity for glucose utilization was measured by using cyclic somatostatin. Overnight fasting plasma glucose concentrations decreased in NIDDM-NO; however, 24-hr UCPR was reduced in both NIDDM-NO and healthy controls by diet restriction (25 kcal/kg) for 14 days. The level of 24-hr UCPR was higher but insulin sensitivity was lower in NIDDM-NO as compared with those in healthy controls. Therefore, diet restriction may be effective in controlling hyperglycemia and hypersecretion of insulin in NIDDM-NO, but it alone may not improve the reduced insulin sensitivity.
Oshima
Y
Y
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002097:C-Reactive Protein / Q000652:urine*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000178:diet therapy / Q000652:urine*; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D007328:Insulin; D008297:Male; D008875:Middle Aged; D013004:Somatostatin
D001786:Blood Glucose; D007328:Insulin; D013004:Somatostatin; D002097:C-Reactive Protein