title: Dynamics of beta-adrenoceptor blockade with cetamolol.
abstract: Cetamolol is a new beta-adrenoceptor blocking agent shown in animals to have moderate beta 1-adrenoceptor selectivity and partial agonist activity. In healthy normal volunteers, beta 1-adrenoceptor blockade was measured as the reduction of exercise-induced tachycardia, systolic blood pressure, and double product at 2, 8, and 24 h after a single oral dose of 10, 25, and 50 mg cetamolol. beta 1-adrenoceptor blockade was significantly linearly related to log serum cetamolol level, was maximal at 2 h, and was still clinically significant at 24 h. A crossover study of single 0, 10, and 25 mg doses confirmed these findings.
authors.forename: J
authors.initials: J
authors.lastname: Coelho
authors.forename: K
authors.initials: K
authors.lastname: Schnelle
authors.forename: L
authors.initials: L
authors.lastname: Joubert
authors.forename: D
authors.initials: D
authors.lastname: Ventura
authors.forename: J
authors.initials: J
authors.lastname: Mullane
mesh_terms: D000081:Acetamides / Q000097:blood / Q000494:pharmacology*; D000293:Adolescent; D000319:Adrenergic beta-Antagonists; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D005082:Physical Exertion; D011869:Radioligand Assay
chemical_list: D000081:Acetamides; D000319:Adrenergic beta-Antagonists; C038931:cetamolol