Intrarenal kallikrein-kinin activity in acute renovascular hypertension in dogs.
The intrarenal kallikrein-kinin system was studied during the acute phase of renovascular hypertension induced by renal artery constriction and during teprotide inhibition of kininase II in the dog. Kallikrein-like activity measured by both kininogenase and esterolytic assays, was increased during renal artery constriction (p less than 0.5) and (p less than 0.01). The administration of teprotide resulted in a further increase of renal cortical kallikrein-like activity and inhibited kininase II activity (p less than 0.01). Following the inhibition of kininase II, the plasma concentration of kininogen was also significantly decreased (p less than 0.01). These results suggest that kininase II inhibition may increase levels of intrarenal and plasma kinins and that decreased degradation of kinin peptides may contribute significantly to the acute hypertensive effect of teprotide.
Verma
P S
PS
Department of Medicine, College of Medicine, Howard University, Washington, D.C.
Gagnon
J A
JA
Miller
R L
RL
D000818:Animals; D004285:Dogs; D006978:Hypertension, Renovascular / Q000201:enzymology*; D007610:Kallikreins / Q000378:metabolism*; D007704:Kininogens / Q000097:blood; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D013722:Teprotide / Q000494:pharmacology
D007704:Kininogens; D013722:Teprotide; D007703:Peptidyl-Dipeptidase A; D007610:Kallikreins