Histamine2-receptor antagonists in gastroduodenal ulcer haemorrhage.
This paper reviews randomised trials in which the effects of histamine2-receptor antagonists have been studied in gastroduodenal ulcer haemorrhage. There is a trend in these studies that histamine2-receptor antagonists may reduce the number of rebleedings, especially in elderly patients with gastric ulcers. A randomised trial comparing cimetidine and ranitidine in high risk patients with massive gastroduodenal haemorrhage is also presented. The total mortality in this study was 12%, 15% for gastric ulcer patients and 11% for duodenal ulcer patients. There was no difference in mortality, amount of blood transfusion required, rebleedings or need for emergency surgery between the two treatment models.
Falk
A
A
Darle
N
N
Haglund
U
U
Törnqvist
A
A
D000368:Aged; D002927:Cimetidine / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000150:complications*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy*; D011897:Random Allocation; D011899:Ranitidine / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000150:complications*
D006635:Histamine H2 Antagonists; D002927:Cimetidine; D011899:Ranitidine