Intrathecal administration of beta-endorphin and dynorphin-(1-13) for the treatment of intractable pain.
Seven cases of chronic pain were treated by intrathecal administration of 30 micrograms of beta-endorphin and dynorphin-(1-13). Compared with saline, both peptides were able to suppress pain for periods up to 4.5 and 7 hours on the average, respectively. No significant side reactions were noticed during the entire investigation.
Wen
H L
HL
Mehal
Z D
ZD
Ong
B H
BH
Ho
W K
WK
Wen
D Y
DY
D000328:Adult; D000368:Aged; D002544:Cerebral Infarction / Q000503:physiopathology; D004399:Dynorphins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004723:Endorphins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006562:Herpes Zoster / Q000503:physiopathology; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000503:physiopathology; D010148:Intractable Pain / Q000188:drug therapy*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014948:Wounds, Gunshot / Q000503:physiopathology; D001615:beta-Endorphin
D004723:Endorphins; D010446:Peptide Fragments; D001615:beta-Endorphin; C026843:dynorphin (1-13); D004399:Dynorphins