Expression of the c-myb and c-myc genes is regulated independently in differentiating mouse erythroleukemia cells by common processes of premature transcription arrest and increased mRNA turnover.
The mechanisms that modulate c-myb mRNA levels in mouse erythroleukemia cells induced toward erythroid differentiation were compared with those that act on c-myc. Both genes exhibited regulation at the levels of premature transcription arrest and RNA turnover. However, these common processes allowed temporally distinct control of gene expression.
Watson
R J
RJ
Imperial Cancer Research Fund Laboratories, St. Bartholomew's Hospital, Bartholomew Close, London, United Kingdom.
D000818:Animals; D004262:DNA Restriction Enzymes; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D007700:Kinetics; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics; D007942:Leukemia, Experimental / Q000235:genetics*; D051379:Mice; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes / Q000187:drug effects; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects
D012333:RNA, Messenger; D004262:DNA Restriction Enzymes; D004121:Dimethyl Sulfoxide