Significance of particle size of mebendazole in the treatment of tapeworm infections.
Taenia hydatigena and Echinococcus granulosus in dogs have been used as a model to evaluate the response of these parasites to increasing doses of mebendazole in different dose forms (powder, micronized powder and tablets of micronized powder). Overall the micronized powder proved to be the most active, the tablets less so and the normal powder least active. Statistical confirmation was obtained that the use of this drug in different dose forms changed the rate of the response, suggesting that in the treatment of human hydatid disease caused by Echinococcus spp and cysticercosis caused by Taenia solium, the dosage form may be a vital factor in the drug's efficacy.
Gemmell
M A
MA
Johnstone
P D
PD
Oudemans
G
G
D000818:Animals; D001682:Biological Availability; D002590:Cestode Infections / Q000188:drug therapy*; D004285:Dogs; D066298:In Vitro Techniques; D008463:Mebendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D010316:Particle Size; D011208:Powders
D011208:Powders; D008463:Mebendazole