title: Treatment with itraconazole of widespread tinea corporis due to Trichophyton rubrum in a bone marrow transplant recipient.
abstract: An immunocompromised patient, 6 weeks after bone marrow transplantation, developed extensive skin infection due to Trichophyton rubrum. Because she could not tolerate ketoconazole and was hypersensitive to griseofulvin, she received itraconazole with complete recovery within 30 days. This case demonstrates that itraconazole may be effective treatment for dermatophytosis, even in immunocompromised hosts, and that there is no cross-reactivity between ketoconazole and itraconazole.
authors.affiliation: Department of Clinical Microbiology, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Engelhard
authors.forename: R
authors.initials: R
authors.lastname: Or
authors.forename: E
authors.initials: E
authors.lastname: Naparstek
authors.forename: V
authors.initials: V
authors.lastname: Leibovici
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009190:Myelodysplastic Syndromes / Q000628:therapy; D014005:Tinea / Q000188:drug therapy* / Q000209:etiology
chemical_list: D017964:Itraconazole; D007654:Ketoconazole