title: Acquired immunodeficiency syndrome in the child of a haemophiliac.
abstract: Oral thrush developed during the second month of life in the 5-month-old son of a patient with haemophilia A. He did not feed well, and interstitial pneumonitis, lymphadenopathy, hepatosplenomegaly, and a cellular immune defect consistent with the acquired immunodeficiency syndrome (AIDS) followed. Both parents had signs of pre-AIDS during the year before their son's illness. Transmission presumably occurred in 3 steps: parenterally, via factor VIII concentrate in the haemophiliac; heterosexually, from the haemophiliac to his wife; and vertically, from mother to infant, or via close paternal-infant or maternal-infant contact. This first report of AIDS in the child of a haemophiliac supports the theory that AIDS is caused by an infectious agent. Concentrate-treated haemophiliacs may transmit this agent to their spouses or children, resulting in pre-AIDS or AIDS.
authors.forename: M V
authors.initials: MV
authors.lastname: Ragni
authors.forename: A H
authors.initials: AH
authors.lastname: Urbach
authors.forename: S
authors.initials: S
authors.lastname: Kiernan
authors.forename: J
authors.initials: J
authors.lastname: Stambouli
authors.forename: B
authors.initials: B
authors.lastname: Cohen
authors.forename: B S
authors.initials: BS
authors.lastname: Rabin
authors.forename: A
authors.initials: A
authors.lastname: Winkelstein
authors.forename: J C
authors.initials: JC
authors.lastname: Gartner
authors.forename: B Z
authors.initials: BZ
authors.lastname: Zitelli
authors.forename: J J
authors.initials: JJ
authors.lastname: Malatack
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics* / Q000276:immunology / Q000635:transmission; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D002675:Child, Preschool; D017977:Deltaretrovirus / Q000276:immunology; D005169:Factor VIII / Q000627:therapeutic use; D005260:Female; D006467:Hemophilia A / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D000914:Antibodies, Viral; D005169:Factor VIII