title: Teicoplanin, its pharmacokinetics, blister and peritoneal fluid penetration.
abstract: The pharmacokinetics of a 440 mg iv dose of teicoplanin were studied in six male volunteers. The levels of the compound were measured microbiologically in serum, blister fluid and urine. The mean serum level 0-5 h after injection was 44.6 mg 1(-1), falling to 3.6 mg 1(-1) at 49 h. The serum elimination half-life of teicoplanin when fitted to a two-compartment model was 34.2 h; a three-compartment model gave a longer half-life. The apparent distribution half-life was 1.5 h. Penetration into cantharides induced blister fluid was moderately fast, the mean maximum concentration (14.8 mg 1(-1)) occurring at 2.7 h, the mean percentage penetration being 77.4%. Urinary recovery of the drug was 48.3% by 96 h. The drug penetrated rapidly into the non-inflammed peritoneal fluid of 34 patients undergoing elective surgery. The percentage penetration being 40% within the first hour, and 94.6% over the period of the study.
authors.forename: R
authors.initials: R
authors.lastname: Wise
authors.forename: I A
authors.initials: IA
authors.lastname: Donovan
authors.forename: C A
authors.initials: CA
authors.lastname: McNulty
authors.forename: R
authors.initials: R
authors.lastname: Waldron
authors.forename: J M
authors.initials: JM
authors.lastname: Andrews
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000097:blood / Q000378:metabolism*; D001202:Ascitic Fluid / Q000378:metabolism*; D001768:Blister / Q000378:metabolism*; D006020:Glycopeptides / Q000097:blood / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D017334:Teicoplanin
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D017334:Teicoplanin