title: Effect of paf-acether on isoprenaline-induced relaxation in isolated tracheal segments of rats and guinea pigs.
abstract: Platelet activating factor (paf-acether) was found to contract rat and guinea pig tracheal segments. It does not cause down regulation of beta-adrenoceptor in guinea pig trachea. In addition, paf-contracted rat tracheal segments lose their ability to relax in response to isoprenaline.
authors.affiliation: Department of Pharmacology, Wallace Laboratories, Division of Carter-Wallace, Inc., Cranbury, NJ 08512.
authors.forename: N
authors.initials: N
authors.lastname: Chand
authors.forename: W
authors.initials: W
authors.lastname: Diamantis
authors.forename: R D
authors.initials: RD
authors.lastname: Sofia
mesh_terms: D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D010972:Platelet Activating Factor / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D014132:Trachea / Q000187:drug effects*
chemical_list: D010972:Platelet Activating Factor; D011943:Receptors, Adrenergic, beta; D002217:Carbachol; D007545:Isoproterenol