[Induction of gamma-glutamyltransferase in cultured brain cells].
gamma-Glutamyltransferase is a membrane-bound enzyme widely distributed in animal tissues. This enzyme is involved in glutathione metabolism, but its exact biological function is still an open question. In rat brain cells in culture a depletion of L-cystine and L-glutamine or the addition of diethyl maleate to the culture medium leads to a decrease of intracellular glutathione concentration and to an increase of the specific activity of gamma-glutamyltransferase. The induction of the enzyme is inhibited by the addition of cycloheximide or actinomycin D to the culture medium.
Müller
W H
WH
Freimüller-Kreutzer
B
B
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002478:Cells, Cultured; D003513:Cycloheximide / Q000494:pharmacology; D003553:Cystine / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D005973:Glutamine / Q000494:pharmacology; D008298:Maleates / Q000494:pharmacology; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000096:biosynthesis*
D008298:Maleates; D005973:Glutamine; D003609:Dactinomycin; D003553:Cystine; D003513:Cycloheximide; D005723:gamma-Glutamyltransferase; C014476:diethyl maleate
Induktion der gamma-Glutamyltransferase bei Hirnzellen in Kultur.