[Decrease in the level and enzymatic activity of cytochrome P-450 during diethylnitrosamine metabolism in vivo and in vitro].
Diethylnitrosamine (DENA) intoxication of rats was accompanied by a reduction of cytochrome P-450 content in the liver, which correlated well with inactivation of cytochrome P-450 during metabolism of DENA in the liver microsomes.
Goloshchapov
O F
OF
Koen
Ia M
IaM
Shuliakovskaia
T S
TS
Kaiushin
L P
LP
D000818:Animals; D001711:Biotransformation; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004052:Diethylnitrosamine / Q000493:pharmacokinetics / Q000633:toxicity*; D004578:Electron Spin Resonance Spectroscopy; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D065607:Cytochrome P-450 Enzyme Inhibitors; D004052:Diethylnitrosamine; D003577:Cytochrome P-450 Enzyme System
Snizhenie soderzhaniia i fermentativnoĭ aktivnosti tsitokhroma P-450 v khode metabolizma diétilnitrozamina in vivo i in vitro.