title: Non-invasive method for early diagnosis of herpes simplex encephalitis.
abstract: For the early diagnosis of herpes simplex encephalitis IgG and IgM antibodies to herpes simplex virus in cerebrospinal fluid were measured by an enzyme linked immunosorbent assay (ELISA) and a local production index was calculated. Using these three criteria, 31 cases of various neurological illnesses were analysed. All eight cases of herpes simplex encephalitis were diagnosed correctly in the acute phase, and there were no false positive results.
authors.affiliation: Department of Paediatrics, Nagoya University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hanada
authors.forename: S
authors.initials: S
authors.lastname: Kido
authors.forename: M
authors.initials: M
authors.lastname: Terashima
authors.forename: K
authors.initials: K
authors.lastname: Nishikawa
authors.forename: T
authors.initials: T
authors.lastname: Morishima
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004660:Encephalitis / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006561:Herpes Simplex / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007159:Immunologic Tests / Q000379:methods; D007223:Infant; D007231:Infant, Newborn; D018139:Simplexvirus / Q000276:immunology; D013997:Time Factors
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M