[Interaction of the calcium antagonists nifedipine and nisoldipine with the nondepolarizing muscle relaxant vecuronium bromide in an vivo rat preparation].
The interaction of two orally administered Ca-channel blockers, the dihydropyridines nisoldipine and nifedipine, with the non-depolarizing muscle relaxant, vecuronium bromide, was tested in the indirectly stimulated tibialis anterior muscle of anesthetized and ventilated Sprague-Dawley rats. In both the nisoldipine and the nifedipine group, depression of twitch tension and duration of vecuronium-induced neuromuscular blockade was potentiated when compared with a control group. The possible clinical relevance of these findings is discussed.
Ilias
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Steinbereithner
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D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004357:Drug Synergism; D009132:Muscles / Q000187:drug effects*; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D009543:Nifedipine / Q000031:analogs & derivatives / Q000494:pharmacology*; D015737:Nisoldipine; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014673:Vecuronium Bromide
D002121:Calcium Channel Blockers; D003473:Neuromuscular Nondepolarizing Agents; D015737:Nisoldipine; D014673:Vecuronium Bromide; D009543:Nifedipine; D010197:Pancuronium
Zur Wechselwirkung der Ca-Antagonisten Nifedipin und Nisoldipin mit dem nichtdepolarisierenden Muskelrelaxans Vecuroniumbromid im "in vivo" Rattenpräparat.