Susceptibility of Bordetella pertussis to doxycycline, cinoxacin, nalidixic acid, norfloxacin, imipenem, mecillinam and rifampicin.
The susceptibility of Bordetella pertussis to doxycycline, cinoxacin, nalidixic acid, norfloxacin, imipenem (N-formimidoyl-thienamycin), mecillinam and rifampicin was studied by agar and broth dilution. There were discrepancies between MICs registered on solid medium and in fluid medium. There seems to be a need for methodological studies on the antibiotic susceptibility of Bord. pertussis using different techniques. None of the compounds tested seemed to be realistic alternatives to the well documented erythromycin.
Zackrisson
G
G
Brorson
J E
JE
Björnegård
B
B
Trollfors
B
B
D000560:Amdinocillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001886:Bordetella pertussis / Q000187:drug effects*; D002937:Cinoxacin / Q000494:pharmacology; D004318:Doxycycline / Q000494:pharmacology; D015378:Imipenem; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D009643:Norfloxacin; D012293:Rifampin / Q000494:pharmacology; D013845:Thienamycins / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D013845:Thienamycins; D009268:Nalidixic Acid; D015378:Imipenem; D002937:Cinoxacin; D009643:Norfloxacin; D004318:Doxycycline; D000560:Amdinocillin; D012293:Rifampin