Case report of prolactin and bipolar illness: a longitudinal study.
A longitudinal and naturalistic study of nine bipolar patients attending a lithium clinic during a six-month period was undertaken. Prolactin plasma levels and psychiatric symptoms were evaluated bi-weekly. Wide interindividual and intraindividual fluctuations were observed both in prolactin levels and psychiatric symptoms. The relationship between prolactin and affective episodes was found to be complex. In a few instances, sharp prolactin changes preceded behavioral modifications. Bipolar disorders, even if treated, appeared to be unstable conditions, from both the phenomenological and neuroendocrinological viewpoints.
Fava
G A
GA
Molnar
G
G
Spinks
M
M
Loretan
A
A
Edwards
L
L
Morphy
M A
MA
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood*; D010054:Brief Psychiatric Rating Scale; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*
D011388:Prolactin