Serotonin and dopamine as regulators of adenylate cyclase and relaxation in a smooth muscle of the mussel Mytilus edulis.
Serotonin and dopamine show similar dose-response relationships when they relax tonically contracted intact muscle fibres of the anterior byssus retractor muscle of Mytilus edulis. In saponin-treated muscle fibers, only serotonin or high doses of dopamine relax tonic contraction. In a membrane fraction, enriched in adenylate cyclase activity, serotonin and dopamine increase the rate of cAMP production. Serotonin is a far more potent activator of adenylate cyclase than dopamine.
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D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D049872:Bivalvia / Q000502:physiology; D004298:Dopamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D000262:Adenylyl Cyclases; D004298:Dopamine