Ouabain-induced changes in extracellular aspartate, glutamate and GABA levels in the rabbit olfactory bulb in vivo.
The effect of ouabain on extracellular amino acid levels was investigated in the rabbit olfactory bulb using brain dialysis. Extracellular field potentials, elicited by stimulation of the lateral olfactory tract (LOT), were recorded simultaneously. Ouabain (100 microM) induced a rapid increase in extracellular aspartate, glutamate and gamma-aminobutyric acid. LOT-evoked potentials changed concomitantly, suggesting a neuronal depolarization.
Jacobson
I
I
Hagberg
H
H
Sandberg
M
M
Hamberger
A
A
D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D001224:Aspartic Acid / Q000032:analysis; D005071:Evoked Potentials / Q000187:drug effects; D005110:Extracellular Space / Q000032:analysis; D005971:Glutamates / Q000032:analysis; D018698:Glutamic Acid; D009830:Olfactory Bulb / Q000032:analysis* / Q000201:enzymology; D010042:Ouabain / Q000494:pharmacology*; D011817:Rabbits; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D000596:Amino Acids; D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase