[Effect of beta-adrenoreceptor blockade on cell division processes in the corneal and tongue epithelium of white rats with chronic oxygen starvation].
A study was made of the changes in the mitotic activity, DNA synthesis, and the number of pathological mitoses after administration of the beta-adrenoblocker propranolol in the corneal and tongue epithelium of white rats kept in pressure chamber for 7 days (4 h daily) at a "height" of 9000 meters. The mitotic and the label indices (inclusion of 3H-thymidine by the epithelium nuclei) were analysed for mitotic activity and DNA synthesis, respectively. The experiments showed that the mitotic activity, DNA synthesis, the number of pathological mitoses were stabilized due to the propranolol administration.
Vdovenko
S V
SV
Timoshin
S S
SS
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002908:Chronic Disease; D003315:Cornea / Q000187:drug effects* / Q000473:pathology; D004247:DNA / Q000096:biosynthesis; D004848:Epithelium / Q000187:drug effects; D005898:Glass / Q000494:pharmacology; D000860:Hypoxia / Q000473:pathology*; D008297:Male; D008938:Mitosis / Q000187:drug effects; D051381:Rats; D014059:Tongue / Q000187:drug effects* / Q000473:pathology
D000319:Adrenergic beta-Antagonists; C036485:obsidian; D004247:DNA
Vliianie blokady beta-adrenoretseptorov na protsessy kletochnogo deleniia épiteliia rogovitsy i iazyka belykh krys pri khronicheskom kislorodnom golodanii.