Influence of methionine-enkephalin analogue (FK-33-824) on the secretion of pancreatic hormones.
To determine the effects of methionine-enkephalin on secretion of pancreatic hormones, five healthy male adults were intramuscularly given 0.5 mg of FK 33-824, a methionine-enkephalin analog and blood levels of pancreatic hormones were measured at different time intervals. FK 33-824 significantly lowered basal levels of plasma insulin (IRI) and pancreatic polypeptide and decreased IRI secretion in 75 g-OGTT. It also delayed the elevation of blood sugar level in 75 g-OGTT. No change occurred in the basal levels of plasma glucagon, somatostatin and blood sugar. These results imply that methionine-enkephalin in the pancreas and alimentary tract may act as an inhibitor on the secretion of insulin and pancreatic polypeptide and hence relates to the absorption of sugar.
Sekiya
K
K
Funakoshi
A
A
Shinozaki
H
H
Nawata
H
H
Kato
K
K
Ibayashi
H
H
D000328:Adult; D000818:Animals; D000941:Antigens / Q000032:analysis; D001786:Blood Glucose / Q000378:metabolism; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin / Q000494:pharmacology*; D005934:Glucagon / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D010187:Pancreatic Hormones / Q000097:blood / Q000378:metabolism*; D010191:Pancreatic Polypeptide / Q000097:blood; D011817:Rabbits; D011863:Radioimmunoassay; D013004:Somatostatin / Q000097:blood; D013997:Time Factors
D000941:Antigens; D001786:Blood Glucose; D007328:Insulin; D010187:Pancreatic Hormones; D013004:Somatostatin; D010191:Pancreatic Polypeptide; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D005934:Glucagon