Prolongation of thiopentone-induced sleep by trazodone and its metabolite, m-chlorophenylpiperazine.
Trazodone and its metabolite, m-chlorophenylpiperazine (CPP) prolonged significantly thiopentone-induced sleep in mice. Neither trazodone, nor CPP changed the cerebral concentrations of thiopentone. As cyproheptadine by itself did not affect thiopentone sleep and did not antagonize the effect of CPP, the effect of trazodone and CPP seems to be independent of their respective 5-HT-antagonistic and 5-HT-agonistic properties.
Adamus
A
A
Sansone
M
M
Melzacka
M
M
Vetulani
J
J
D000758:Anesthesia; D000818:Animals; D001921:Brain / Q000378:metabolism; D004357:Drug Synergism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010879:Piperazines / Q000494:pharmacology*; D013874:Thiopental / Q000378:metabolism; D013997:Time Factors; D014196:Trazodone / Q000378:metabolism / Q000494:pharmacology*
D010879:Piperazines; D013874:Thiopental; C015068:1-(3-chlorophenyl)piperazine; D014196:Trazodone