[Participation of the central noradrenergic system in the mechanisms of latent inhibition].
Male Wistar rats were learnt to conditioned reaction of passive avoidance 10 days after intraperitoneal administration of 50 mg/kg of specific neurotoxin DSP4. The character of conditioned reaction reproduction, duration of its conservation and its stability against amnestic processing were analyzed. It has been found that reduction of activity of noradrenergic coerulo-cortical system does not influence the conditioned reaction reproduction but inhibits its spontaneous extinction and prevents amnesia development. The obtained data are discussed in aspect of central noradrenaline participation in latent inhibition mechanisms.
Loskutova
L V
LV
D000647:Amnesia / Q000503:physiopathology; D000818:Animals; D001596:Benzylamines / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004558:Electric Stimulation; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects; D009498:Neurotoxins / Q000494:pharmacology; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology*; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D001596:Benzylamines; D009498:Neurotoxins; D011941:Receptors, Adrenergic; C012102:DSP 4; D009638:Norepinephrine
Uchastie tsentral'noĭ noradrenergicheskoĭ sistemy v mekhanizmakh latentnogo tormozheniia.