title: The significance of central nicotine receptors in the aggression of isolated mice.
abstract: The effect of nicotine, and some nicotinic antagonists on aggressive behavior of isolated mice was tested. Nicotine in doses of 0.5-2 mg/kg ip and 0.005-0.06 mg/mouse ivtr potentiated the aggressiveness. However, higher doses nicotine (4 mg/kg ip and 0.09 mg/kg (Polfa). Co-suppressed the aggression. Mecamylamine, a central nicotinic antagonist in a dose of 2 mg/kg facilitated the aggression while in doses of 4 and 8 mg/kg inhibited it. Hexamethonium, a peripheral nicotinic antagonist, partially suppressed the aggressive behavior. Our results indicate that central nicotinic receptors have also a certain role in mediating the investigated type of mouse aggression.
authors.forename: Z
authors.initials: Z
authors.lastname: Roliński
authors.forename: M
authors.initials: M
authors.lastname: Herbut
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D051379:Mice; D009538:Nicotine / Q000494:pharmacology*; D010830:Physostigmine / Q000494:pharmacology; D011978:Receptors, Nicotinic / Q000502:physiology*; D012934:Social Isolation
chemical_list: D006584:Hexamethonium Compounds; D011978:Receptors, Nicotinic; D018738:Hexamethonium; D008464:Mecamylamine; D009538:Nicotine; D010830:Physostigmine