title: Ventricular fluid somatostatin concentration decreases in childhood-onset dystonia.
abstract: Somatostatin was measured in CSF from individuals with a variety of neurologic diseases. In ventricular CSF, somatostatin concentration was significantly lower in individuals with childhood-onset dystonia than in individuals with other forms of dystonia or with other disorders. Severity of childhood dystonia correlated with somatostatin concentration, suggesting a progressive dysfunction of somatostatin-containing neurons with increasing disease severity. There were no significant differences in somatostatin concentration in lumbar CSF. Multiple forms of immunoreactive somatostatin were found in a pool of lumbar CSF from normal individuals. Labeled somatostatin administered intra-arterially to rats failed to cross the blood-brain barrier.
authors.forename: L J
authors.initials: LJ
authors.lastname: Thal
authors.forename: N S
authors.initials: NS
authors.lastname: Sharpless
authors.forename: D
authors.initials: D
authors.lastname: Rosenbaum
authors.forename: P
authors.initials: P
authors.lastname: Davies
authors.forename: I M
authors.initials: IM
authors.lastname: Amin
authors.forename: J M
authors.initials: JM
authors.lastname: Waltz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001923:Brain Chemistry; D002648:Child; D004421:Dystonia / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013004:Somatostatin / Q000134:cerebrospinal fluid*
chemical_list: D013004:Somatostatin