Persistence of poliovirus-neutralizing antibodies 2-16 years after immunization with live attenuated vaccine. A seroepidemiologic survey in the mainland of Venice.
A seroepidemiological survey was conducted on subjects who had received a full vaccination course with live attenuated poliovirus 2-16 years before. For strains 1 and 2 prevalence of seropositives and median values dropped gradually during the first 10 years; strain 3 showed a much earlier decline. Environmental displacement of wild poliovirus by the attenuated, less immunogenic strain might eventually induce a 'gap', should complacency hamper needed vaccination efforts.
Trivello
R
R
School of Hygiene and Preventive Medicine, University of Padua, Italy.
Renzulli
G
G
Farisano
G
G
Bonello
C
C
Moschen
M
M
Gasparini
V
V
Benussi
G
G
D000914:Antibodies, Viral / Q000276:immunology*; D006801:Humans; D009500:Neutralization Tests; D017955:Poliovirus / Q000276:immunology*; D011055:Poliovirus Vaccine, Oral / Q000276:immunology*; D011446:Prospective Studies; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000276:immunology
D000914:Antibodies, Viral; D011055:Poliovirus Vaccine, Oral; D014613:Vaccines, Attenuated