Anti-Epstein-Barr virus antibodies in systemic lupus erythematosus.
Sera from 18 patients with Systemic Lupus Erythematosus (SLE), 20 with nonA-nonB acute hepatitis and 19 healthy subjects were tested for the presence of antibodies to the viral capside of Epstein-Barr virus. In patients with SLE the mean titre of anti-VCA IgG was significantly higher than in normal subjects (p less than 0.02), and the percentage of patients with titres greater than 1:160 was significantly higher than in normal population (p less than 0.01). These high anti-VCA) titres in SLE patients are probably related to a defective immune surveillance.
Origgi
L
L
Istituto di Medicina Interna, Università degli Studi di Milano, Italy.
Perego
R
R
Hu
C
C
Bertetti
E
E
D'Agostino
P
P
Asero
R
R
Riboldi
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis*; D002213:Capsid / Q000276:immunology; D005260:Female; D006526:Hepatitis C / Q000276:immunology*; D006525:Hepatitis, Viral, Human / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis* / Q000276:immunology; D007157:Immunologic Surveillance; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000914:Antibodies, Viral; D007074:Immunoglobulin G