Prophylactic and therapeutic efficacy of the soman-simulator, pinacolyl dimethylphosphinate.
Atropinized rats, intoxicated with 6 or 8 X LD50 soman and subsequently treated with the oxime HI-6 died several hours after intoxication. Oral or intravenous administration of the soman-simulator, pinacolyl dimethylphosphinate (PDP), given at progressively increasing time intervals before soman, appeared to be very active in preventing death and secondary failure of neuromuscular transmission that followed HI-6-induced recovery. Therapeutically, PDP was only effective when given immediately after soman intoxication and oxime treatment. In animals that received no treatment otherwise, intravenous administration of PDP 10 min before intoxication with 1 X LD50 soman did not enhance lethality.
Van Helden
H P
HP
van der Wiel
H J
HJ
Wolthuis
O L
OL
D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects; D010091:Oximes; D011726:Pyridinium Compounds / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012999:Soman / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity*; D009435:Synaptic Transmission / Q000187:drug effects; D013997:Time Factors
D000931:Antidotes; D010091:Oximes; D011726:Pyridinium Compounds; D001285:Atropine; C048957:pinacolyl dimethylphosphinate; D012999:Soman; C022870:asoxime chloride