Systemic mastocytosis associated with membranous nephropathy and peripheral neuropathy.
A report of the occurrence of membranous nephropathy and peripheral neuropathy in a patient with systemic mastocytosis is presented. Previous reviews of patients with systemic mastocytosis have not noted this association. During cyclical therapy with prednisone and chlorambucil in this case, nephrotic-range proteinuria remitted. Peripheral neuropathy resolved 10 months after discontinuation of therapy. Pathophysiological mechanisms resulting in this clinical presentation may be immunologically mediated.
Lal
S M
SM
Department of Medicine, University of Missouri Health Sciences Center, Columbia 65212.
Brooks
C S
CS
Luger
A M
AM
Davenport
J G
JG
Weber
R D
RD
Loy
T S
TS
Haibach
H H
HH
D003711:Demyelinating Diseases / Q000150:complications / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D008415:Mastocytosis / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications* / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000150:complications*; D013497:Sural Nerve / Q000473:pathology