title: [Effectiveness and tolerance of metipranolol--results of a multi-center long-term study in Switzerland].
abstract: The results of this continuing multicenter study revealed a good efficacy and tolerance of Metipranolol used in patients with ocular hypertension and chronic open-angle glaucoma. After 4 weeks' treatment a reduction in average intraocular pressure of 5.6 mmHg could be observed. This favorable effect on pressure values could be confirmed during long-term treatment up to 16 weeks (average reduction in intraocular pressure of 5.9 mmHg equal to 25%). More than 90% of patients treated with 0.1% Metipranolol showed very good or good tolerance. In conclusion, it can be established that 0.1% Metipranolol has also confirmed its value in daily practice and offers an interesting possibility for low-dosage beta-blocker therapy.
authors.forename: O
authors.initials: O
authors.lastname: Müller
authors.forename: H R
authors.initials: HR
authors.lastname: Knobel
mesh_terms: D002986:Clinical Trials as Topic; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008134:Long-Term Care; D014290:Metipranolol / Q000009:adverse effects / Q000627:therapeutic use*; D009798:Ocular Hypertension / Q000188:drug therapy*; D011412:Propanolamines / Q000627:therapeutic use*; D013557:Switzerland
chemical_list: D011412:Propanolamines; D014290:Metipranolol
vernacular_title: Wirksamkeit und Verträglichkeit von Metipranolol--Resultate einer multizentrischen Langzeitstudie in der Schweiz.