[Hepatitis and mononucleosis syndrome related to the ingestion of salazosulfapyridine].
The authors report the case of a patient treated by salazosulfapyridine and presenting with hepatitis and mononucleosis. The clinical pattern was similar to infectious mononucleosis including pharyngitis and lymphadenopathy but infection by Epstein Barr virus or cytomegalovirus has been ruled out by serological tests. Responsibility of salazosulfapyridine was highly suggested by the following facts: hepatocellular necrosis was sharply centrolobular, plasmocytosis was the main finding in the white blood cells count and all abnormalities rapidly improved after treatment withdrawal. The authors point out that salazosulfapyridine intolerance could mimic infectious mononucleosis and viral hepatitis. In such cases the drug must be rapidly withdrawn to avoid massive hepatic necrosis.
Labadie
H
H
Beaugrand
M
M
Ferrier
J P
JP
D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003937:Diagnosis, Differential; D006801:Humans; D007244:Infectious Mononucleosis / Q000175:diagnosis*; D008297:Male; D012460:Sulfasalazine / Q000009:adverse effects*; D013577:Syndrome
D012460:Sulfasalazine
Hépatite et syndrome mononucléosique liés à la prise de salazosulfapyridine.