Science policy choices and the estimation of cancer risk associated with exposure to TCDD.
United States regulatory agencies use no-threshold models for estimating carcinogenic risks. Other countries use no-threshold models for carcinogens that are genotoxic and threshold models for carcinogens that are not genotoxic, such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD or "dioxin"). The U.S. Environmental Protection Agency has proposed a revision of the carcinogenic potency estimate for TCDD that is based on neither a threshold nor a no-threshold model; instead, it is a compromise between risk numbers generated by the two irreconcilably different models. This paper discusses the revision and its implications.
Gough
M
M
Center for Risk Management, Resources for the Future, Washington, D.C. 20036.
D002273:Carcinogens; D004147:Dioxins / Q000633:toxicity*; D006801:Humans; D008452:Maximum Allowable Concentration; D015233:Models, Statistical; D009369:Neoplasms / Q000139:chemically induced*; D000072317:Polychlorinated Dibenzodioxins / Q000008:administration & dosage / Q000633:toxicity*; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug / Q000187:drug effects; D012307:Risk Factors; D014481:United States; D014484:United States Environmental Protection Agency
D002273:Carcinogens; D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug