Acetyl CoA carboxylase inhibitors from the fungus Gongronella butleri.
Four active metabolites that specifically inhibit acetyl CoA carboxylase, the late-limiting enzyme in fatty acid biosynthesis, have been isolated from a strain of Gongronella butleri mating type (+). Their chemical structures were determined to be octyl pentanedioic acid, 9-decenyl-1-pentenedioic acid, decanyl-1-pentenedioic acid, decanyl-2-pentenedioic acid, respectively. These compounds inhibited rat liver acetyl CoA carboxylase 50% at a concentration of 30 approximately 55 micrograms/ml.
Endo
A
A
Takeshima
H
H
Kuwabara
K
K
D000103:Acetyl-CoA Carboxylase / Q000037:antagonists & inhibitors*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D008025:Ligases / Q000037:antagonists & inhibitors*; D009090:Mucorales / Q000378:metabolism*; D051381:Rats
D004791:Enzyme Inhibitors; D008025:Ligases; D000103:Acetyl-CoA Carboxylase