The influence of dimetindene maleate on the endogenous hydrocortisone synthesis suppressing potency of betamethasone.
Plasma hydrocortisone (cortisol) levels in 7 healthy volunteers were measured following administration of 0.25 mg betamethasone or 0.25 mg betamethasone and 1 mg dimetindene maleate. The H1-receptor antagonist dimetindene maleate did not influence the hydrocortisone suppressing activity of betamethasone, which was proved by comparison with the published plasma hydrocortisone levels of 162 young healthy untreated volunteers.
Rehn
D
D
Haack
D
D
Vecsei
P
P
Hennings
G
G
D000328:Adult; D001623:Betamethasone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002940:Circadian Rhythm; D004115:Dimethindene / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000096:biosynthesis* / Q000097:blood; D008297:Male
D006634:Histamine H1 Antagonists; D004115:Dimethindene; D001623:Betamethasone; D006854:Hydrocortisone