[Effect of 5-aminosalicylic acid as a constituent of sulfasalazine in the treatment of chronic polyarthritis].
Sulphasalazine, a combination of sulphapyridine and 5-aminosalicylic acid, has recently been shown to be an effective second line agent in the treatment of rheumatoid arthritis. 20 patients were treated for 12 weeks either with sulphasalazine or 5-aminosalicylic acid (5-ASA) to investigate whether 5-ASA is the active moiety. In a second investigation the analgesic effect of 5-ASA was studied. 5-ASA showed no second line effect and no analgesic effect. Sulphapyridine therefore appears to be the active moiety.
Wörth
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Müller
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D000328:Adult; D000368:Aged; D000636:Aminosalicylic Acids / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007596:Joints / Q000187:drug effects; D008297:Male; D019804:Mesalamine; D008875:Middle Aged; D012460:Sulfasalazine / Q000627:therapeutic use*
D000636:Aminosalicylic Acids; D012460:Sulfasalazine; D019804:Mesalamine
Die Wirkung der 5-Aminosalicylsäure als Bestandteil des Sulphasalazins in der Behandlung der chronischen Polyarthritis.