[Functional morphology of stomach secretions].
The stimulation of gastric secretion is regulated by neurovagal, endocrine and immunological reactions. During the gastric phase of digestion, especially acetylcholin, gastrin and histamin react as main transmitters, activated by mediators (prostaglandines, leucotrienes, lipoxygenases). The dominant role of nervus vagus has to be seen in the transactions of vago-vagal reflexes, the stimulation of gastrin liberation by an non-cholinergic mechanism and the regulation of the gastric microcirculation. The antrum pylori can be seen as an immunological area of reception, where immunological active cells (macrophages, NK-lymphocytes and T-lymphocytes) are recognizing antigens (e.g. food antigens). These immunocytes induce a cascade of endocrine and exocrine mechanisms of digestion. Mastcells, located intra-and extraepithelial, take a regulatory influence in producing histamins, leucotrienes and also prostaglandines.
Liebich
H G
HG
D000818:Animals; D002118:Calcium / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D005744:Gastric Acid / Q000378:metabolism*; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000033:anatomy & histology; D005755:Gastrins / Q000502:physiology; D006632:Histamine / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000502:physiology; D008407:Mast Cells / Q000648:ultrastructure; D008854:Microscopy, Electron; D018377:Neurotransmitter Agents / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology; D013270:Stomach / Q000033:anatomy & histology*; D009435:Synaptic Transmission; D014630:Vagus Nerve / Q000033:anatomy & histology
D005755:Gastrins; D007136:Immunoglobulins; D018377:Neurotransmitter Agents; D011453:Prostaglandins; D006632:Histamine; D000242:Cyclic AMP; D002118:Calcium
Funktionelle Morphologie der Magensekretion.