title: [Effect of ascorbic acid on the hepatocarcinogenic action of N-nitrosodiethylamine in rats].
abstract: It is shown that the ascorbic acid (AA) administration to Wistar male rats (50 mg per animal intraperitoneally 3 times a week) accelerates hepatocarcinogenesis induced by N-nitrosodiethylamine (2.5 mg/kg 6 times a week in drinking water). In this case the activity of glucose-6-phosphate dehydrogenase in liver increases, while that of glucose-6-phosphatase decreases.
authors.forename: R V
authors.initials: RV
authors.lastname: Birk
authors.forename: L A
authors.initials: LA
authors.lastname: Kil'dema
authors.forename: L E
authors.initials: LE
authors.lastname: Teras
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D001205:Ascorbic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D004128:Dimethylnitrosamine / Q000493:pharmacokinetics / Q000633:toxicity*; D004347:Drug Interactions; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D005954:Glucosephosphate Dehydrogenase; D005952:Glucose-6-Phosphatase; D004128:Dimethylnitrosamine; D001205:Ascorbic Acid
vernacular_title: Vliianie askorbinovoĭ kisloty na gepatokantserogennoe deĭstvie N-nitrozodiétilamina u krys.