title: Changes in B lymphocyte function in rheumatoid arthritis and lupus nephritis after total lymphoid irradiation.
abstract: Patients with rheumatoid arthritis and patients with lupus nephritis underwent total lymphoid irradiation (TLI). Peripheral blood mononuclear cells from these patients showed a decrease in pokeweed mitogen-induced immunoglobulin secretion after TLI. A defect in non-T cells contributed to the decreased response. No defect in the response of non-T cells to T cell-independent activators of B cells, Staphylococcus aureus Cowan 1 and Epstein-Barr virus, was observed after TLI. We conclude that TLI induces a selective deficit in B cells, which respond to T cell-dependent mitogen stimulation.
authors.affiliation: Department of Medicine, Stanford University Medical Center, CA 94305-5111.
authors.forename: J J
authors.initials: JJ
authors.lastname: Solovera
authors.forename: M C
authors.initials: MC
authors.lastname: Fariñas
authors.forename: S
authors.initials: S
authors.lastname: Strober
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000628:therapy*; D001402:B-Lymphocytes / Q000502:physiology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis / Q000378:metabolism; D008181:Lupus Nephritis / Q000276:immunology* / Q000628:therapy*; D015182:Lymphatic Irradiation; D008213:Lymphocyte Activation; D008297:Male; D009000:Monocytes / Q000502:physiology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007136:Immunoglobulins; D011043:Pokeweed Mitogens