Comparison of clenbuterol enantiomers using four psychopharmacological tests sensitive to beta-agonists.
The effects of the enantiomers of clenbuterol were compared in four psychopharmacological tests in which beta-adrenergic agonists are known to be active. In mice (+/-)-clenbuterol 0.06 mg/kg decreased motor activity and antagonized the hypothermia induced by 16 mg/kg of apomorphine; at 0.5 mg/kg it increased head-twitches and tremors induced by 1-5-hydroxytryptophan (4 mg/kg) and decreased the number of bites of a food pellet by mice which had been maintained on a water only diet for 24-27 h ('Tantale' test). The present results show that the (-) form is responsible for this activity and that the (+) form has no effect per se and does not antagonize the (-) enantiomer.
Martin
P
P
Puech
A J
AJ
Brochet
D
D
Soubrié
P
P
Simon
P
P
D006916:5-Hydroxytryptophan / Q000037:antagonists & inhibitors; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D002976:Clenbuterol / Q000494:pharmacology*; D004983:Ethanolamines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013237:Stereoisomerism; D014202:Tremor / Q000139:chemically induced
D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D006916:5-Hydroxytryptophan; D001058:Apomorphine; D002976:Clenbuterol