title: The activity of nitrofurazone and furazolidone against Leishmania donovani, L. major and L. enriettii in vitro and in vivo.
abstract: Furazolidone and nitrofurazone showed in vitro activity against amastigotes of Leishmania donovani, L. enriettii and L. major in macrophages, at concentrations which were also toxic to the macrophages. A low grade of activity was observed against L. donovani infections in BALB/c mice by furazolidone but not with nitrofurazone. Nitrofurazone, in two concentrations, was not active when applied to the lesions of cutaneous leishmaniasis due to L. enriettii (guinea-pig infection) or L. major strain P (BALB/c mouse infection). After systemic administration to BALB/c mice infected with L. major strain JISH 252 clone 1, low-grade activity was observed at the highest level tested.
authors.affiliation: London School of Hygiene and Tropical Medicine, Winches Farm Laboratories, St. Albans, U.K.
authors.forename: R A
authors.initials: RA
authors.lastname: Neal
authors.forename: J
authors.initials: J
authors.lastname: van Bueren
authors.forename: G
authors.initials: G
authors.lastname: Hooper
mesh_terms: D000818:Animals; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use; D005664:Furazolidone / Q000494:pharmacology*; D006168:Guinea Pigs; D007891:Leishmania / Q000187:drug effects*; D007893:Leishmania donovani / Q000187:drug effects; D007894:Leishmania mexicana / Q000187:drug effects; D007895:Leishmania tropica / Q000187:drug effects; D007896:Leishmaniasis / Q000188:drug therapy / Q000469:parasitology; D008264:Macrophages / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D009583:Nitrofurazone / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D005664:Furazolidone; D000967:Antimony Sodium Gluconate; D009583:Nitrofurazone