title: Alpha 1-adrenoceptor function in the rat hippocampus as assessed by noradrenaline-stimulated inositol phospholipid breakdown after destruction of noradrenergic neurons by neonatal 6-hydroxydopamine treatment.
abstract: Neonatal 6-hydroxydopamine treatment of male Sprague-Dawley rats resulted in a large depletion of noradrenaline 84-87 days later, as demonstrated by an 82% reduction in the intra-synaptosomal deamination of [14C]noradrenaline within noradrenergic synaptosomes with only marginal effects upon the extrasynaptosomal deamination. The hippocampal stimulation of inositol phospholipid breakdown by noradrenaline was, however, unaffected by the neonatal 6-hydroxydopamine treatment.
authors.forename: C J
authors.initials: CJ
authors.lastname: Fowler
authors.forename: I
authors.initials: I
authors.lastname: Fagervall
authors.forename: B G
authors.initials: BG
authors.lastname: Minor
authors.forename: S B
authors.initials: SB
authors.lastname: Ross
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology; D007295:Inositol Phosphates / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology* / Q000502:physiology; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D013403:Sugar Phosphates / Q000378:metabolism*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
chemical_list: D006892:Hydroxydopamines; D007295:Inositol Phosphates; D011942:Receptors, Adrenergic, alpha; D013403:Sugar Phosphates; D016627:Oxidopamine; D009638:Norepinephrine