title: Hypergastrinemia develops within 24 hours of truncal vagotomy in dogs.
abstract: Postvagotomy hypergastrinemia may result from withdrawal of tonic vagal inhibitory mechanism(s) or from G-cell hyperplasia secondary to diminished acid secretion. Early development of hypergastrinemia, after vagotomy, would favor the first mechanism, whereas delayed development would favor the second. We sought to distinguish between these two mechanisms and to determine whether alterations in somatostatin release might mediate postvagotomy hypergastrinemia. We measured plasma concentrations of gastrin and somatostatinlike immunoreactivity basally and in response to meal (pH controlled at 5.5) and to insulin hypoglycemia before and after truncal vagotomy in 11 dogs. Basal and postprandial hypergastrinemia were established within 24 and 48 h after vagotomy, respectively. Basal and meal-stimulated plasma somatostatinlike immunoreactivity concentrations were unaltered by vagotomy, although insulin hypoglycemia-induced rises in plasma somatostatinlike immunoreactivity were abolished by vagotomy. Our data suggest that neither G-cell hyperplasia nor alterations in somatostatin release explain postvagotomy hypergastrinemia in the dog. The observations support the hypothesis that postvagotomy hypergastrinemia results from the withdrawal of a tonic vagal inhibitory mechanism of gastrin release that is independent of somatostatin. Whether the tonic vagal inhibition of gastrin is direct or indirect is unknown.
authors.forename: J W
authors.initials: JW
authors.lastname: Hollinshead
authors.forename: H T
authors.initials: HT
authors.lastname: Debas
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: J
authors.initials: J
authors.lastname: Elashoff
authors.forename: B
authors.initials: B
authors.lastname: Osadchey
authors.forename: J H
authors.initials: JH
authors.lastname: Walsh
mesh_terms: D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism; D005747:Gastric Fistula / Q000097:blood; D005755:Gastrins / Q000097:blood*; D006632:Histamine; D007003:Hypoglycemia / Q000097:blood; D007328:Insulin; D011184:Postoperative Period; D013004:Somatostatin / Q000097:blood; D013997:Time Factors; D014628:Vagotomy
chemical_list: D005755:Gastrins; D007328:Insulin; D013004:Somatostatin; D006632:Histamine