Effects of co-administration of monomethylaminoantipyrine with diethylaminoethyl 2,2-diphenylvalerate (SKF 525-A) on gamma-glutamyltranspeptidase, glutathione S-transferase and hepatic drug metabolizing enzyme activities in rats.
4-Monomethylaminoantipyrine (MAA)-induced increase of hepatic drug metabolizing enzymes was suppressed by SKF 525-A. This may be due to the partial binding of SKF 525-A to a portion of cytochrome P-450. On the other hand, glutathione S-transferase and gamma-glutamyltranspeptidase (gamma-GTP) activities of rat liver were both induced by repeated administration of MAA in combination with SKF 525-A. In addition, under the same condition, glutathione level in rat liver was significantly decreased.
Hoshi
K
K
Senda
N
N
Igarashi
T
T
Satoh
T
T
Ueno
K
K
Kitagawa
H
H
D000632:Aminopyrine / Q000031:analogs & derivatives*; D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D003600:Cytosol / Q000032:analysis; D004177:Dipyrone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005978:Glutathione / Q000032:analysis; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D011335:Proadifen / Q000008:administration & dosage / Q000494:pharmacology*; D047069:Pyrazolones; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D047069:Pyrazolones; D000632:Aminopyrine; D004177:Dipyrone; D011335:Proadifen; D006899:Mixed Function Oxygenases; D000633:Aminopyrine N-Demethylase; D005723:gamma-Glutamyltransferase; D005982:Glutathione Transferase; D005978:Glutathione; C008667:noramidopyrine