title: Effect of non-ionic surfactants in a polyacrylic acid gel base on the rectal absorption of [Asu1,7]-eel calcitonin in rats.
abstract: The effect of non-ionic surfactants in a polyacrylic acid gel base on the rectal absorption of [Asu1,7]-eel calcitonin, a calcitonin analogue, was studied in rats. Absorption was enhanced by a microenema which used a polyacrylic acid gel base, but it was reduced by the incorporation of polysorbate 80 (0.1-5% v/v). The incorporation of polyoxyethylene 9 lauryl ether (0.1-5% v/v) in the polyacrylic acid gel base enhanced the absorption. Rectal administration in the base containing 0.5% v/v polyoxyethylene 9 lauryl ether required a dose of the calcitonin 2-3 times greater than an intramuscularly administered dose to achieve an equivalent hypocalcaemic effect.
authors.forename: K
authors.initials: K
authors.lastname: Morimoto
authors.forename: H
authors.initials: H
authors.lastname: Akatsuchi
authors.forename: K
authors.initials: K
authors.lastname: Morisaka
authors.forename: A
authors.initials: A
authors.lastname: Kamada
mesh_terms: D000180:Acrylic Resins / Q000378:metabolism; D000818:Animals; D002116:Calcitonin / Q000031:analogs & derivatives* / Q000378:metabolism; D002118:Calcium / Q000097:blood; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012007:Rectum / Q000378:metabolism; D013501:Surface-Active Agents
chemical_list: D000180:Acrylic Resins; D013501:Surface-Active Agents; C006903:carbopol 940; D002116:Calcitonin; D002118:Calcium; C012755:elcatonin