Antidiuretic effect of ritodrine with and without beta-adrenergic blockade.
Dose-related effects of ritodrine and ritodrine combined with metoprolol on urinary excretion rate were studied in anesthetized dogs. Urine production was abruptly reduced after a total dose of 4 micrograms.kg-1 of ritodrine. This effect could not be antagonized by metoprolol, although the ritodrine-induced decrease of mean arterial pressure and renal arterial blood flow was significantly inhibited. The possible role of fluid retention during tocolytic treatment, even with beta-adrenergic blockade, in the etiology of pulmonary edema is discussed with a review on recent literature.
Gerritse
R
R
Pinas
I M
IM
Reuwer
P J
PJ
Haspels
A A
AA
Charbon
G A
GA
Beijer
H J
HJ
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005260:Female; D008790:Metoprolol / Q000494:pharmacology; D012079:Renal Circulation / Q000187:drug effects; D012312:Ritodrine / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D008790:Metoprolol; D012312:Ritodrine