Bronchodilator effects of terbutaline and theophylline alone and in combination in patients with chronic obstructive lung disease.
Thirteen patients with severe partially reversible chronic obstructive lung disease received long-term treatment with a sustained-release preparation of theophylline and a beta 2-agonist (terbutaline) alone and in combination. Combination therapy induced significantly greater bronchodilation than treatment with terbutaline alone in the recommended dose. In 9 out of 13 patients the peak flows were higher during combination therapy than during theophylline treatment alone, but this did not reach statistical significance. Only mild side effects were observed.
Baadsgaard
O
O
Oberg
B
B
Thomsen
L
L
Klitgaard
N
N
Simonsen
E
E
D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use; D013726:Terbutaline / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013806:Theophylline / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D001993:Bronchodilator Agents; D010880:Piperidines; D013806:Theophylline; D013726:Terbutaline