A comparative study of the hepatotoxicity of monochlorobenzene in the rainbow trout (Salmo gairdnerii) and the Sprague-Dawley rat.
Chlorobenzene (CB) was less hepatotoxic to trout than to rats. This difference could not be totally accounted for by reduced absorption in the trout and CB was metabolized in the trout. Glutathione concentrations in trout livers were 1/3 of those of the rat and prior depletion of the tripeptide led to irreversible binding of CB to trout liver protein equivalent to that of rats suffering extensive necrosis. No consistent correlation between glutathione content or protein binding and liver damage was seen in either species.
Dalich
G M
GM
Larson
R E
RE
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001571:Benzoflavones / Q000494:pharmacology; D002722:Chlorobenzenes / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008298:Maleates / Q000494:pharmacology; D009336:Necrosis; D009474:Neurons / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains; D012487:Salmonidae / Q000502:physiology*; D013045:Species Specificity; D013997:Time Factors; D014337:Trout / Q000502:physiology*; D019324:beta-Naphthoflavone
D001571:Benzoflavones; D002722:Chlorobenzenes; D008298:Maleates; D019324:beta-Naphthoflavone; D000410:Alanine Transaminase; C014476:diethyl maleate; D005978:Glutathione; C031294:chlorobenzene; D010634:Phenobarbital