Effect of low protein diet on manganese neurotoxicity: III. Brain neurotransmitter levels.
The effect of concurrent low protein (10% casein) diet and manganese (Mn) exposure (3 mg/ml drinking water) on brain levels of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT) were investigated in Fo-growing (90 days exposure), Fo-diet rehabilitated (low----normal protein diet-28 days) and F1-weaned rats. Mn exposure in either diet group resulted in a significant increase in the DA and NE levels but a decrease in the 5-HT level. These effects were more pronounced in the rats fed the low protein diet, especially in the F1-offsprings. Diet rehabilitation reduced the effects of Mn exposure.
Ali
M M
MM
Murthy
R C
RC
Mandal
S K
SK
Chandra
S V
SV
D000818:Animals; D001923:Brain Chemistry; D001927:Brain Diseases / Q000139:chemically induced*; D004298:Dopamine / Q000032:analysis; D005260:Female; D008297:Male; D020149:Manganese Poisoning; D018377:Neurotransmitter Agents / Q000032:analysis*; D009638:Norepinephrine / Q000032:analysis; D011488:Protein Deficiency / Q000150:complications* / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000032:analysis
D018377:Neurotransmitter Agents; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine