title: Clinical experiences in the administration of a low molecular weight heparin (Fragmin, Kabi-Vitrum) to healthy volunteers and in the treatment of established deep venous thrombosis.
abstract: A low molecular weight heparin (Fragmin, Kabi-Vitrum) with a mean molecular weight of 4,000-5,000 D has been investigated in healthy volunteers and in patients with DVT. We found a T 1/2 of 4 hours and a high bioavailability after subcutaneous injection in volunteers. In a randomised study, patients with phlebographically verified DVT, 120 U(anti-FXa)/kg Fragmin injected twice daily was found to be as effective as 240 U/kg, 12 h standard heparin as continuous infusion in preventing DVT progress. No major bleedings were seen in the Fragmin group. We conclude that Fragmin administered subcutaneously twice daily results in adequate anticoagulation and is safe and practical in the treatment of DVT.
authors.affiliation: Thrombosis Unit, Huddinge University Hospital, Sweden.
authors.forename: G A
authors.initials: GA
authors.lastname: Bratt
authors.forename: E
authors.initials: E
authors.lastname: Törnebohm
authors.forename: M
authors.initials: M
authors.lastname: Johanson
authors.forename: W
authors.initials: W
authors.lastname: Aberg
authors.forename: S
authors.initials: S
authors.lastname: Granqvist
authors.forename: D
authors.initials: D
authors.lastname: Lockner
mesh_terms: D001682:Biological Availability; D004341:Drug Evaluation; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D010690:Phlebography; D011897:Random Allocation; D013924:Thrombophlebitis / Q000000981:diagnostic imaging / Q000188:drug therapy*
chemical_list: D006495:Heparin, Low-Molecular-Weight; D006493:Heparin