[Effect of M-cholinomimetics on nociceptive stimulation in the spinal cord].
Two series of experiments were performed to study the effects of oxotremorine (5, 10 and 20 micrograms/kg), arecoline (0.25, 0.5 and 1.0 mg/kg), pilocarpine (5, 10 and 20 mg/kg) and aceclidine (0.25, 0.5 and 1.0 mg/kg) injected intravenously on nociceptive transmission in the spinal cord of spinal rats. It was established that the m-cholinomimetics inhibit in a dose-dependent manner the nociceptive reflex induced by intraarterial injection of bradykinin. When given in the same doses the drugs reduce the bradykinin-induced bioelectrical activity in the afferent tracts of the spinal cord. Atropine (1 mg/kg i. v.) abolishes the antinociceptive action of the cholinomimetics.
Nemirovskiĭ
A Iu
AIu
D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D006614:Hindlimb / Q000294:innervation; D009619:Nociceptors / Q000187:drug effects*; D010095:Oxotremorine / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology; D011812:Quinuclidines / Q000494:pharmacology; D051381:Rats; D012026:Reflex, Stretch / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D010277:Parasympathomimetics; D011812:Quinuclidines; D010862:Pilocarpine; D001115:Arecoline; D010095:Oxotremorine
Vliianie M-kholinomimetikov na provedenie notsitseptivnogo vozbuzhdeniia v spinnom mozge.