Prolyl derivatives of enalapril as potential angiotensin converting enzyme inhibitors.
The synthesis of a new class of potential angiotensin converting enzyme (ACE) inhibitors, analogs of enalapril, is reported. In these molecules the C-terminal amino acidic sequence Ala-Pro of enalapril was replaced by the sequence Pro-Pro. The compounds were tested both in vitro and in vivo. They showed no in vivo activity but only a week in vitro inhibitory activity.
Ciabatti
R
R
Merrell - Dow Research Institute - Lepetit Research Center - Gerenzano (Va), Italy.
Tarzia
G
G
Battaglia
F
F
Barone
D
D
Baldoli
E
E
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004055:Differential Thermal Analysis; D004656:Enalapril / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D006977:Hypertension, Renal / Q000188:drug therapy / Q000503:physiopathology; D066298:In Vitro Techniques; D051381:Rats; D011919:Rats, Inbred Strains
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril