Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists.
The effectiveness of several excitatory amino acid antagonists to delay or block seizures induced by oxygen at high pressure was examined in mice. Of the antagonists tested, namely, L-proline, DL-alpha-aminoadipate, DL-2-amino-5-phosphonovalerate, and L-glutamic acid diethyl ester, DL-2-amino-5-phosphonovalerate was the most effective in delaying or preventing seizures. L-Glutamic acid diethylester was also effective but at significantly higher doses, which were also associated with marked sedation.
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D015763:2-Amino-5-phosphonovalerate; D015074:2-Aminoadipic Acid / Q000494:pharmacology; D000596:Amino Acids / Q000037:antagonists & inhibitors*; D000818:Animals; D000927:Anticonvulsants; D005971:Glutamates / Q000494:pharmacology; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D051379:Mice; D011392:Proline / Q000494:pharmacology; D012640:Seizures / Q000209:etiology / Q000517:prevention & control*; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
D000596:Amino Acids; D000927:Anticonvulsants; D005971:Glutamates; C011829:glutamic acid diethyl ester; D015074:2-Aminoadipic Acid; D015763:2-Amino-5-phosphonovalerate; D011392:Proline; D014633:Valine