title: Prostaglandin D2-induced potentiation of hexobarbitone hypnosis in rats: role of 5-hydroxytryptamine.
abstract: Prostaglandin D2 (PGD2) produced a dose-related increase in the duration and incidence of induction of sleep induced by hexobarbitone, in rats. Pretreatment with pharmacological agents known to reduce selectively brain 5-hydroxytryptaminergic activity, significantly inhibited PGD2-induced potentiation of hexobarbitone, indicating that this potentiation is mediated by 5-hydroxytryptamine.
authors.forename: S K
authors.initials: SK
authors.lastname: Bhattacharya
authors.forename: S S
authors.initials: SS
authors.lastname: Parmar
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006591:Hexobarbital / Q000494:pharmacology*; D006993:Hypnotics and Sedatives; D007276:Injections, Intraventricular; D008297:Male; D015230:Prostaglandin D2; D011457:Prostaglandins D / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*
chemical_list: D006993:Hypnotics and Sedatives; D011457:Prostaglandins D; D012701:Serotonin; D006591:Hexobarbital; D015230:Prostaglandin D2