Contraction induced by (-)-tartaric acid on rat isolated gastric fundus and its inhibition with indomethacin.
Tartaric acid-evoked contractions of the rat isolated fundus could not be antagonized by atropine sulphate or methysergide hydrogen maleate, but were partially reduced by mepyramine hydrochloride. The contractions were prevented by indomethacin (25 micrograms ml-1) although the tissue remained sensitive to PGE2.
Tuğrul
L
L
Ozer
A
A
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D015232:Dinoprostone; D005260:Female; D005748:Gastric Fundus / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D011458:Prostaglandins E / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013644:Tartrates / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D011458:Prostaglandins E; D013644:Tartrates; D001285:Atropine; D006632:Histamine; D011738:Pyrilamine; D015232:Dinoprostone; D000109:Acetylcholine; C029768:tartaric acid; D007213:Indomethacin