title: Zetidoline, a novel neuroleptic, activates nigral dopaminergic neurons in rats.
abstract: Zetidoline (ZET), a rather selective dopamine (DA) D2-receptor blocker, was found to be equipotent to haloperidol and over 300 times as potent as sulpiride in activating the firing rate of substantia nigra dopaminergic neurons (SN-DA neurons) in unanesthetized rats. Moreover, like classic and atypical neuroleptics, ZET reversed and prevented apomorphine-induced inhibition of SN-DA neurons.
authors.forename: G
authors.initials: G
authors.lastname: Mereu
authors.forename: B
authors.initials: B
authors.lastname: Fanni
authors.forename: M
authors.initials: M
authors.lastname: Collu
authors.forename: A
authors.initials: A
authors.lastname: Diena
authors.forename: A
authors.initials: A
authors.lastname: Glasser
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D004594:Electrophysiology; D006220:Haloperidol / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000166:cytology* / Q000187:drug effects; D013469:Sulpiride / Q000494:pharmacology
chemical_list: D014150:Antipsychotic Agents; D007093:Imidazoles; C027277:zetidoline; D013469:Sulpiride; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine