Histochemical and immunohistochemical detection of putative preneoplastic liver foci in women after long-term use of oral contraceptives.
Localized areas with altered enzyme patterns were observed in liver tissue surrounding focal nodular hyperplasia in women after long-term use of oral contraceptives. These localized lesions were of three different types. Type I lesions were characterized by glycogen storage, a reduction in ATPase and an increase in gamma-glutamyltranspeptidase (gamma-GT) and UDP-glucuronyltransferase (UDP-GT) detected immunohistochemically. Type II lesions, which were morphologically very similar to small hyperplastic nodules, showed only a decreased ATPase reaction. Type III lesions showed an increase in gamma-GT (detected histochemically) and a slight reduction in ATPase. The results indicated that in human liver from patients given oral contraceptives long-term, localized lesions with altered enzyme patterns may occur which are very similar to those observed in animal models during experimental hepatic carcinogenesis.
Fischer
G
G
Hartmann
H
H
Droese
M
M
Schauer
A
A
Bock
K W
KW
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000328:Adult; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D014453:Glucuronosyltransferase / Q000378:metabolism; D006801:Humans; D008112:Liver Glycogen / Q000378:metabolism; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D008875:Middle Aged; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D003276:Contraceptives, Oral; D008112:Liver Glycogen; D005723:gamma-Glutamyltransferase; D014453:Glucuronosyltransferase; D000251:Adenosine Triphosphatases