[Evaluation of the functional state of the leprous macrophages].
Cytochrome oxidase (CCO), peroxidase, succinic dehydrogenase (SDG) and NADH-diaphorase were studied electron-cytochemically in leprous macrophages (LM) of granulomas of patients suffering from lepromatous leprosy. The LM peroxidase activity and location differed, this affecting the completeness of M. leprae phagocytosis. High CCO activity in LM cytoplasm was not a factor essentially influencing M. leprae disintegration. SDG and NADH-diaphorase, locating predominantly in membraneous structures of M. leprae, show low activity in LM cytoplasm.
Maslov
A K
AK
Iushchenko
A A
AA
D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D006801:Humans; D007918:Leprosy / Q000276:immunology / Q000378:metabolism*; D008264:Macrophages / Q000201:enzymology / Q000502:physiology* / Q000648:ultrastructure; D010544:Peroxidases / Q000378:metabolism; D010587:Phagocytosis; D013385:Succinate Dehydrogenase / Q000378:metabolism
D010544:Peroxidases; D013385:Succinate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase; D003576:Electron Transport Complex IV
Otsenka funktsional'nogo sostoyaniya leproznykh makrofagov.