title: The effects of sodium borate and sodium bicarbonate upon fluoride retention and serum calcium and phosphate in sheep.
abstract: Six sheep were each given a fluoride slow-release intra-ruminal capsule which delivered 30 +/- 1.02 mg F/d. After 20 days, fluoride balance studies were carried out for four days and serum fluoride measured daily. Each sheep was then given 23.1 mg sodium borate daily via drench gun for six days, and the balance studies continued. In a separate similar experiment, six sheep were given capsules which released 66.4 +/- 4.2 mg F/d, and 25 ml of 25 g/L sodium bicarbonate was administered half-hourly over four hours, 14 days after capsule administration. Urinary pH was also measured. Sodium borate treatment increased fluoride output, mainly in the faeces, and temporarily reduced serum fluoride concentration. Serum phosphate fell during sodium borate administration, while serum calcium was unaffected. Sodium bicarbonate reduced serum fluoride concentration over the three days, and fluoride output was increased, mainly via the urine, while urinary pH was largely unaffected. Serum calcium and phosphate were temporarily affected to a small extent.
authors.affiliation: N.S.W. Department of Agriculture, Hawkesbury Agricultural Research Unit, Richmond, Australia.
authors.forename: S M
authors.initials: SM
authors.lastname: Wheeler
authors.forename: A D
authors.initials: AD
authors.lastname: Turner
authors.forename: K J
authors.initials: KJ
authors.lastname: Ellis
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D001881:Borates / Q000494:pharmacology*; D002118:Calcium / Q000097:blood*; D002214:Capsules; D003692:Delayed-Action Preparations; D005459:Fluorides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006863:Hydrogen-Ion Concentration; D008297:Male; D010710:Phosphates / Q000097:blood*; D012756:Sheep; D012964:Sodium / Q000494:pharmacology*; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D001881:Borates; D002214:Capsules; D003692:Delayed-Action Preparations; D010710:Phosphates; D017693:Sodium Bicarbonate; C010634:sodium borate; D012964:Sodium; D005459:Fluorides; D002118:Calcium