Isolation of retroviruses from two patients with "common variable" hypogammaglobulinaemia.
Retroviruses related to human T-lymphotropic virus III/lymphadenopathy-associated virus (HTLV-III/LAV) have been isolated from peripheral-blood mononuclear cells of two patients with "common variable" hypogammaglobulinaemia who were being treated with intravenous gammaglobulin. One has had three different opportunistic infections. In both patients hypogammaglobulinaemia developed within 6 years of a longlasting undiagnosed viral-like illness in adolescence, and it is suggested that the virus causing that illness also gave rise to the hypogammaglobulinaemia. However, iatrogenic infection from intravenous gammaglobulin cannot be ruled out.
Webster
A D
AD
Dalgleish
A G
AG
Malkovsky
M
M
Beattie
R
R
Patterson
S
S
Asherson
G L
GL
North
M
M
Weiss
R A
RA
D000293:Adolescent; D000361:Agammaglobulinemia / Q000150:complications / Q000382:microbiology* / Q000628:therapy; D001991:Bronchitis / Q000150:complications; D017977:Deltaretrovirus / Q000302:isolation & purification*; D005260:Female; D006526:Hepatitis C / Q000150:complications; D006562:Herpes Zoster / Q000150:complications; D006801:Humans; D007049:Iatrogenic Disease; D007116:Immunization, Passive / Q000009:adverse effects; D007275:Injections, Intravenous; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000150:complications