title: Experimental models of virus attenuation and demyelinating disease.
abstract: Several lines of evidence suggest that viruses may be aetiologically related to human demyelinating disorders, but no clear causal relationships have been established. In an effort to understand the pathogenesis of virus-induced CNS disease, animal model systems have been employed. Recent results indicate that mutational changes in viral surface components may profoundly affect the course and outcome of disease.
authors.affiliation: Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037.
authors.forename: M J
authors.initials: MJ
authors.lastname: Koolen
authors.forename: M J
authors.initials: MJ
authors.lastname: Buchmeier
mesh_terms: D000818:Animals; D003711:Demyelinating Diseases / Q000382:microbiology*; D004195:Disease Models, Animal; D004680:Maus Elberfeld virus / Q000235:genetics* / Q000472:pathogenicity; D051379:Mice; D006517:Murine hepatitis virus / Q000235:genetics* / Q000472:pathogenicity; D009154:Mutation; D012087:Reoviridae / Q000235:genetics* / Q000472:pathogenicity; D014777:Virus Diseases / Q000382:microbiology