Prostaglandin E1 inhibits calcium-dependent potentials in mammalian sympathetic neurons.
Prostaglandin E1 (PGE1, 10-500 nM) reversibly depressed 3 types of calcium-dependent potentials associated with the spike potential of rabbit superior cervical ganglion cells, namely, the spike after-hyperpolarization, the post-tetanic hyperpolarization, and the Ca2+ spike evoked in a Na+-free/high Ca2+ solution. The results suggest that PGE1 reduces Ca conductance and that this action may underlie its inhibitory action on transmitter release at adrenergic and cholinergic nerve terminals.
Mo
N
N
Ammari
R
R
Dun
N J
NJ
D000200:Action Potentials / Q000187:drug effects; D000527:Alprostadil; D000818:Animals; D002118:Calcium / Q000502:physiology*; D004553:Electric Conductivity; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005728:Ganglia, Sympathetic / Q000187:drug effects*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology*; D011817:Rabbits; D013569:Synapses / Q000378:metabolism
D018377:Neurotransmitter Agents; D011458:Prostaglandins E; D000527:Alprostadil; D002118:Calcium