title: Disposition of radiolabelled suppositories in humans.
abstract: The disposition of Witepsol H 15 suppositories radiolabelled with [99mTc] technetium hydroxymethyldiphosphonate was studied after rectal administration in volunteers. The migration of the radiolabel was monitored continuously by external scintigraphy. The resulting scintiphotos were superimposed on lower GI radiographs to determine the extent of spreading of the dosage form in the rectum. The dosage form migrated approximately 5-7 cm into the rectum in nearly all of the studies and was, in general, confined to the lower and middle regions of the rectum. Since the venous supply to the lower rectum leads primarily to the inferior vena cava, the data presented here indicate that the metabolism of drugs sensitive to the 'first-pass' effect may be partially avoided by their rectal administration.
authors.forename: M
authors.initials: M
authors.lastname: Jay
authors.forename: R M
authors.initials: RM
authors.lastname: Beihn
authors.forename: G A
authors.initials: GA
authors.lastname: Digenis
authors.forename: F H
authors.initials: FH
authors.lastname: Deland
authors.forename: L
authors.initials: L
authors.lastname: Caldwell
authors.forename: A R
authors.initials: AR
authors.lastname: Mlodozeniec
mesh_terms: D000328:Adult; D004164:Diphosphonates; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D012007:Rectum / Q000000981:diagnostic imaging / Q000378:metabolism; D013488:Suppositories; D013667:Technetium; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives*; D013997:Time Factors; D014280:Triglycerides / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D004164:Diphosphonates; D013488:Suppositories; D014280:Triglycerides; C009683:witepsol; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013667:Technetium; D013669:Technetium Tc 99m Medronate