Somatostatin increases the ratio between gastric mucosal blood flow and gastric acid and pepsin secretion in dogs.
The effects of somatostatin on gastric mucosal blood flow (GMBF), acid secretion, and pepsin secretion were evaluated. Conscious gastric fistula dogs were used, with neutral red clearance as the method for estimating the mucosal blood flow. Somatostatin inhibited the pentagastrin- and bethanechol-stimulated gastric acid and pepsin secretion and resulted in an absolute decrease in mucosal blood flow. The ratios between GMBF and secretion (acid and pepsin) were increased during somatostatin infusion, which suggests a relative increase in mucosal blood flow and independent inhibition of gastric secretion. It may be concluded from this study that the acid- and pepsin-inhibitory effects of somatostatin are not mediated by changes in the GMBF.
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D000818:Animals; D001626:Bethanechol Compounds / Q000037:antagonists & inhibitors; D004285:Dogs; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects; D008297:Male; D010418:Pentagastrin / Q000037:antagonists & inhibitors; D010434:Pepsin A / Q000378:metabolism*; D012039:Regional Blood Flow / Q000187:drug effects; D012636:Secretory Rate / Q000187:drug effects; D013004:Somatostatin / Q000494:pharmacology*
D001626:Bethanechol Compounds; D013004:Somatostatin; D010434:Pepsin A; D010418:Pentagastrin