Effect of beta h-endorphin on release of insulin by rabbit pancreas in response to four secretagogues: comparison with somatostatin and epinephrine.
Previous work showed beta h-endorphin inhibits glucose-stimulated secretion of insulin by rabbit pancreas slices. This study, also conducted with rabbit pancreas slices, compared the antisecretagogue actions of beta h-endorphin, somatostatin 1-14, and epinephrine versus four secretagogues, glucose, mannose, leucine and potassium chloride. All three antisecretagogues inhibited all four secretagogues. The order of potency of the antisecretagogues varied according to secretagogue. Naloxone antagonized only beta h-endorphin among the three antisecretagogues, and phentolamine antagonized only epinephrine.
Rudman
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Kutner
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D000818:Animals; D004723:Endorphins / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D009270:Naloxone / Q000494:pharmacology; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010646:Phentolamine / Q000494:pharmacology; D011817:Rabbits; D013004:Somatostatin / Q000494:pharmacology*; D001615:beta-Endorphin
D004723:Endorphins; D007328:Insulin; D009270:Naloxone; D013004:Somatostatin; D001615:beta-Endorphin; D004837:Epinephrine; D010646:Phentolamine