title: Sjögren-like syndrome after drug-induced toxic epidermal necrolysis.
abstract: 7 of 9 patients recovering from a drug-induced toxic epidermal necrolysis (TEN) which they had had 2 months to 4 years before had xerostomia, or keratoconjunctivitis sicca, or both. 5 patients had symptoms; 2 had severe visual impairment. In 5 cases there was lymphocytic infiltration of small salivary glands; in 2 patients this was identical to that of Sjögren syndrome. None of the patients had antinuclear antibody. TEN may occur during acute graft-versus-host disease (GVHD) and these observations are reminiscent of the sicca syndromes reported during chronic GVHD. They suggest that autoimmune mechanisms may be involved in drug-induced TEN and that Sjögren syndrome may occur as the result of a drug reaction.
authors.forename: J C
authors.initials: JC
authors.lastname: Roujeau
authors.forename: C
authors.initials: C
authors.lastname: Phlippoteau
authors.forename: M
authors.initials: M
authors.lastname: Koso
authors.forename: J
authors.initials: J
authors.lastname: Wechsler
authors.forename: C
authors.initials: C
authors.lastname: Andre
authors.forename: M
authors.initials: M
authors.lastname: Binaghi
authors.forename: J
authors.initials: J
authors.lastname: Revuz
authors.forename: R
authors.initials: R
authors.lastname: Touraine
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005128:Eye Diseases / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012469:Salivary Glands / Q000473:pathology; D012859:Sjogren's Syndrome / Q000209:etiology* / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000473:pathology