Inhibitory potential of acetaminophen and o-, m-, p- aminophenols for development of gamma-glutamyltranspeptidase-positive liver cell foci in rats pretreated with diethylnitrosamine.
The inhibitory potential of treatment with acetaminophen (AAP) and 3 different isometric forms of monoaminophenols (o-, m-, p-AP) for the development of gamma-glutamyltranspeptidase-positive (gamma-GT+) liver cell foci was examined in an in vivo short-term assay system. Rats were initially given a single intraperitoneal injection of diethylnitrosamine (DEN) and fed test compounds from week 2 until they were killed at week 6, all rats being subjected to two-thirds partial hepatectomy at week 3. All 4 compounds exerted obvious inhibition of the development of gamma-GT foci with both number and area (mm2) being reduced. AAP proved the most potent agent whereas dose-related inhibitory potential was observed within the 2 doses of p-AP treated.
Kurata
Y
Y
Tsuda
H
H
Tamano
S
S
Ito
N
N
D000082:Acetaminophen / Q000494:pharmacology*; D000627:Aminophenols / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004052:Diethylnitrosamine; D008099:Liver / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000201:enzymology / Q000517:prevention & control*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011230:Precancerous Conditions / Q000201:enzymology / Q000517:prevention & control*; D051381:Rats; D011916:Rats, Inbred F344; D005723:gamma-Glutamyltransferase / Q000032:analysis*
D000627:Aminophenols; D000082:Acetaminophen; D004052:Diethylnitrosamine; D005723:gamma-Glutamyltransferase