Lack of effects of emulsified propofol ('Diprivan') on vecuronium pharmacodynamics--preliminary results in man.
The possible interaction between vecuronium and propofol or thiopentone has been investigated. Cumulative dose response curves for vecuronium and the pharmacodynamic variables measured were similar with both anaesthetic agents. Patients were intubated following the topical application of lignocaine to the larynx and before the administration of vecuronium. A greater degree of relaxation of the vocal cords was noted in patients anaesthetized with propofol.
De Grood
P M
PM
Van Egmond
J
J
Van De Wetering
M
M
Van Beem
H B
HB
Booij
L H
LH
Crul
J F
JF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004655:Emulsions; D006801:Humans; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000494:pharmacology; D010636:Phenols / Q000008:administration & dosage*; D015742:Propofol; D013874:Thiopental / Q000494:pharmacology; D014673:Vecuronium Bromide
D004655:Emulsions; D009466:Neuromuscular Blocking Agents; D010636:Phenols; D014673:Vecuronium Bromide; D010197:Pancuronium; D013874:Thiopental; D015742:Propofol