[Izokorin--a new blockader of gamma-aminobutyric acid receptors in the mammalian nervous system].
Experiments on isolated neurons of sensory ganglions of rats aimed to find physiologically active plant drugs were carried out by means of voltage-clamp, intracellular perfusion and "concentration-clamp" methods. Izokorin was shown to exert blocking action on GABA-activated currents as bicuculline and korlumin. It is suggested that other bicuculline-like alkaloids corresponding to isomers can exert the same effect on GABA-activated currents.
Valeev
A E
AE
Chernevskaia
N I
NI
Dzhakhangirov
F N
FN
Israilov
I A
IA
Iunusov
M S
MS
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D066298:In Vitro Techniques; D007536:Isomerism; D008564:Membrane Potentials / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D009424:Nervous System Physiological Phenomena; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D013329:Structure-Activity Relationship; D014276:Trigeminal Nerve / Q000187:drug effects / Q000502:physiology
D000470:Alkaloids; D011963:Receptors, GABA-A; D001640:Bicuculline
Izokorin--novyĭ blokator retseptorov gamma-aminomaslianoĭ kisloty v nervnoĭ sisteme mlekopitaiushchikh.