title: The mechanism of ischemia-induced brain cell injury. The membrane theory.
abstract: Temporal ischemia of the brain injures only the selectively vulnerable brain cells. The dying process evolves along with glutamate-mediated intracellular signal-transduction system, together with a loss of Ca2+ homeostasis. Such post-ischemic changes eventually disrupt functional and structural integrity of the cell membrane and kill the neuron. Molecular basis in pharmacoprotective agents is discussed.
authors.affiliation: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kogure
authors.forename: J
authors.initials: J
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Araki
mesh_terms: D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000166:cytology* / Q000473:pathology / Q000648:ultrastructure; D001930:Brain Injuries / Q000503:physiopathology*; D002545:Brain Ischemia / Q000503:physiopathology*; D002121:Calcium Channel Blockers / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D002470:Cell Survival; D005849:Gerbillinae; D008854:Microscopy, Electron; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000502:physiology; D012964:Sodium / Q000502:physiology
chemical_list: D002121:Calcium Channel Blockers; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D012964:Sodium