title: [The GABA-ergic system and brain edema].
abstract: It has been shown in rats with experimental toxic and traumatic edemas that picrotoxin (1 mg/kg) removes the antiedematous action of diazepam, phenazepam, phenibut and amizyl and reduces the action of phentolamine. When the dose of picrotoxin is minimized to 0.5 mg/kg such an effect is not observed. Prolonged daily administration of picrotoxin in a dose of 1 mg/kg results in the development of brain edema. It is recommended that GABA-positive drugs be included into a complex of treatment measures for edema.
authors.forename: V S
authors.initials: VS
authors.lastname: Iasnetsov
authors.forename: V E
authors.initials: VE
authors.lastname: Novikov
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D001535:Benactyzine / Q000627:therapeutic use; D001569:Benzodiazepines; D001570:Benzodiazepinones; D001929:Brain Edema / Q000188:drug therapy / Q000209:etiology*; D001930:Brain Injuries / Q000150:complications; D003975:Diazepam / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D005260:Female; D008297:Male; D009538:Nicotine / Q000633:toxicity; D010276:Parasympatholytics / Q000627:therapeutic use; D010646:Phentolamine / Q000627:therapeutic use; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D014151:Anti-Anxiety Agents; D001535:Benactyzine; D001569:Benzodiazepines; D001570:Benzodiazepinones; D003975:Diazepam; D009538:Nicotine; D010276:Parasympatholytics; D010646:Phentolamine; D010852:Picrotoxin; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; C017928:phenazepam; C008842:4-amino-3-phenylbutyric acid
vernacular_title: GAMK-ergicheskaia sistema i otek golovnogo mozga.