Reduction of high affinity glutamate uptake in rat hippocampus by two polyamine-like toxins isolated from the venom of the predatory wasp Philanthus triangulum F.
Two components of the venom of the predatory wasp Philanthus triangulum F. significantly reduce--to a greater or less extent--the high affinity uptake of glutamate in rat hippocampus. A concentration of 10 microM delta-PTX caused a reduction of 74%, while the other component, beta-PTX, at the same concentration, caused a reduction of 18%. Hence the effect of delta-PTX on high affinity glutamate uptake in the hippocampus is comparable with its effect on high affinity glutamate uptake in insect neuromuscular junctions. Contrary to our previous findings that beta-PTX has no effect on high affinity glutamate uptake in insect glutamatergic terminal axons, however, beta-PTX significantly reduces high affinity glutamate uptake in the hippocampus, albeit less effectively than delta-PTX.
van Marle
J
J
Piek
T
T
Lind
A
A
van Weeren-Kramer
J
J
D000818:Animals; D001514:Bee Venoms / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006624:Hippocampus / Q000378:metabolism*; D007313:Insecta / Q000378:metabolism; D009469:Neuromuscular Junction / Q000378:metabolism; D011073:Polyamines / Q000494:pharmacology*; D051381:Rats; D014862:Wasp Venoms / Q000494:pharmacology*
D001514:Bee Venoms; D005971:Glutamates; D011073:Polyamines; D014862:Wasp Venoms; D018698:Glutamic Acid; C034092:delta-philanthotoxin; C048056:beta-philanthotoxin