6,7-Dihydro-5-[[(cis-2-hydroxy-trans-3-phenoxycyclopentyl)amino] methyl]-2-methylbenzo[b]thiophen-4(5H)-one: a novel alpha 1-adrenergic receptor antagonist and renal vasodilator.
McCarthy
J R
JR
Zimmerman
M B
MB
Trepanier
D L
DL
LeTourneau
M E
ME
Wiedeman
P E
PE
Whitten
J P
JP
Broersma
R J
RJ
Shea
P J
PJ
Wiech
N L
NL
Huffman
J C
JC
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011224:Prazosin / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D011918:Rats, Inbred SHR; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology; D012079:Renal Circulation / Q000187:drug effects*; D013237:Stereoisomerism; D013876:Thiophenes / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D014664:Vasodilation / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D011942:Receptors, Adrenergic, alpha; D013876:Thiophenes; C046470:MDL 19744A; D011224:Prazosin