Regional differences in rat brain displayed by fast MRI with superparamagnetic contrast agents.
Gradient echo images of coronal sections through the brains of normal rats have been recorded at 2.0 T both before and at various times after intravenous bolus administrations of a superparamagnetic iron oxide suspension. The decrease in NMR signal due to the transit of the contrast agent has been quantified as a function of time. The image immediately following the injection can be subtracted from that pre-contrast to reveal regional differences related to blood flow.
Majumdar
S
S
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06510.
Zoghbi
S S
SS
Gore
J C
JC
D000818:Animals; D001810:Blood Volume; D001921:Brain / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D004578:Electron Spin Resonance Spectroscopy; D005290:Ferric Compounds; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013670:Sodium Pertechnetate Tc 99m; D013382:Subtraction Technique
D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide; D013670:Sodium Pertechnetate Tc 99m