title: Digestive tract endoluminal perfusion of cisapride (R 51619) and effects on gastrointestinal hormone levels in anaesthetized pigs.
abstract: The authors evaluated the in vivo effects of the new drug Cisapride on gastrointestinal hormone release in the mini-pig. Cisapride has been reported to stimulate and coordinate peristalsis of the GI tract. Selective endoluminal perfusion with Cisapride solution of the isolated but not denervated gastric antrum, duodenum and distal ileum demonstrated a significant increase of gastrin levels following perfusion of the gastric antrum and a decrease in vasoactive intestinal peptide following perfusion of the duodenum, only at very high doses.
authors.forename: U
authors.initials: U
authors.lastname: Caruso
authors.forename: E
authors.initials: E
authors.lastname: Lezoche
authors.forename: M
authors.initials: M
authors.lastname: Elli
authors.forename: G
authors.initials: G
authors.lastname: Tisone
authors.forename: P
authors.initials: P
authors.lastname: Mariani
authors.forename: D
authors.initials: D
authors.lastname: D'Alessandro
authors.forename: E
authors.initials: E
authors.lastname: Cravotto
authors.forename: P A
authors.initials: PA
authors.lastname: Lombardo
authors.forename: M
authors.initials: M
authors.lastname: Tavolaro
authors.forename: M
authors.initials: M
authors.lastname: Silvaroli
mesh_terms: D000818:Animals; D020117:Cisapride; D004305:Dose-Response Relationship, Drug; D005260:Female; D005755:Gastrins / Q000097:blood; D005768:Gastrointestinal Hormones / Q000097:blood*; D007700:Kinetics; D010191:Pancreatic Polypeptide / Q000097:blood; D010477:Perfusion; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D013004:Somatostatin / Q000097:blood; D013552:Swine; D013556:Swine, Miniature; D014660:Vasoactive Intestinal Peptide / Q000097:blood
chemical_list: D005755:Gastrins; D005768:Gastrointestinal Hormones; D010880:Piperidines; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D010191:Pancreatic Polypeptide; D020117:Cisapride