Intestinal metaplasia as a common option of oval cells in relation to cholangiofibrosis in liver of rats exposed to 2-acetylaminofluorene.
Oval cell proliferation in the liver was studied in rats exposed to dietary 2-acetylaminofluorene for 2 weeks with partial hepatectomy performed midway at 1 week. Using autoradiography after either continuous or pulse exposure to [3H]thymidine, histochemical staining for leucine aminopeptidase and gamma-glutamyltransferase, and transmission electron microscopy, we found that every animal showed islands of oval cells with small intestinal metaplasia at 3 weeks. Transitions from these islands of metaplasia to cholangiofibrosis were commonly seen. The importance of small intestinal metaplasia of oval cells in the genesis of cholangiofibrosis is presented and discussed.
Tatematsu
M
M
Kaku
T
T
Medline
A
A
Farber
E
E
D015073:2-Acetylaminofluorene; D000818:Animals; D001345:Autoradiography; D001660:Biliary Tract Diseases / Q000473:pathology*; D006651:Histocytochemistry; D007421:Intestine, Small / Q000201:enzymology / Q000473:pathology; D007931:Leucyl Aminopeptidase / Q000032:analysis; D008099:Liver / Q000201:enzymology; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D008679:Metaplasia / Q000473:pathology; D051381:Rats; D011916:Rats, Inbred F344; D005723:gamma-Glutamyltransferase / Q000032:analysis
D015073:2-Acetylaminofluorene; D005723:gamma-Glutamyltransferase; D007931:Leucyl Aminopeptidase