title: Hepatocellular carcinoma after danazol therapy.
abstract: Danazol, an inhibitor of pituitary gonadotropin, has been proposed in the treatment of systemic lupus erythematosus (SLE). We report the case of a female patient with SLE in whom a hepatocellular carcinoma was discovered after 4 years of treatment with danazol. Except for 3 days of hypochondrium pain, there were neither clinical signs of liver tumor nor biological abnormalities. An ultrasonography showed 2 tumors of the liver. At histological examination after surgery, one of the tumors was found to be a benign adenoma, while the other was a well differentiated hepatocellular carcinoma. When longterm danazol therapy is required, ultrasonography may be useful for early tumor detection.
authors.affiliation: Rheumatology Department, Hôpital Cochin, Paris, France.
authors.forename: B J
authors.initials: BJ
authors.lastname: Weill
authors.forename: C J
authors.initials: CJ
authors.lastname: Menkès
authors.forename: C
authors.initials: C
authors.lastname: Cormier
authors.forename: A
authors.initials: A
authors.lastname: Louvel
authors.forename: M
authors.initials: M
authors.lastname: Dougados
authors.forename: D
authors.initials: D
authors.lastname: Houssin
mesh_terms: D000236:Adenoma / Q000139:chemically induced / Q000175:diagnosis; D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000175:diagnosis; D003613:Danazol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000175:diagnosis; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy; D011245:Pregnadienes / Q000009:adverse effects*; D014463:Ultrasonography
chemical_list: D011245:Pregnadienes; D003613:Danazol