title: [Intensive basic therapy decreases the need for drug treatment and improves glucose control: an important result of the diabetes intervention study].
abstract: In a period of five years in the diabetes intervention study (DIS), 1,139 diabetics aged 30-55 years, who in a 6-week screening phase had been classified as dietetically manageable, were treated in a controlled randomized study with intensified non-medicamentous basic therapy and--in a double blind trial--with 1,6 g clofibric acid. The essential components of the basic therapy were a fat-modified diet (so-called prudent diet) and recommendations for endurance training. Thus in comparison to the control group we succeeded in performing a ca. 40% decrease of the application of oral antidiabetic drugs. The fasting blood values were, nevertheless, with 155 mg% significantly lower than in the control group (169 mg%). Clofibric acid had no influence neither on the necessity to use insulin or oral antidiabetic drugs nor to the control of glycaemia.
authors.affiliation: Klinik für Innere Medizin, Medizinischen Akademie Carl Gustav Carus Dresden.
authors.forename: M
authors.initials: M
authors.lastname: Hanefeld
authors.forename: J
authors.initials: J
authors.lastname: Schulze
authors.forename: S
authors.initials: S
authors.lastname: Fischer
authors.forename: G
authors.initials: G
authors.lastname: Rössger
authors.forename: J
authors.initials: J
authors.lastname: Lindner
authors.forename: G
authors.initials: G
authors.lastname: Groh
authors.forename: A
authors.initials: A
authors.lastname: Nehring
authors.forename: R
authors.initials: R
authors.lastname: Capek
mesh_terms: D002986:Clinical Trials as Topic; D002994:Clofibrate / Q000031:analogs & derivatives*; D002995:Clofibric Acid / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003924:Diabetes Mellitus, Type 2 / Q000534:rehabilitation*; D003927:Diet, Diabetic; D004041:Dietary Fats / Q000008:administration & dosage; D004043:Dietary Fiber / Q000008:administration & dosage; D004311:Double-Blind Method; D015444:Exercise; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage; D026741:Physical Therapy Modalities / Q000379:methods*; D011897:Random Allocation
chemical_list: D004041:Dietary Fats; D004043:Dietary Fiber; D007004:Hypoglycemic Agents; D007328:Insulin; D002995:Clofibric Acid; D002994:Clofibrate
vernacular_title: Intensivierte Basistherapie verringert die Notwendigkeit medikamentöser Behandlung und verbessert die Glukosekontrolle: ein wichtiges Ergebnis der Diabetesinterventionsstudie (DIS).