Effects of psyllium fiber and short-chain organic acids derived from fiber breakdown on colonic epithelial cells from high-risk patients.
The effect of a purified fiber, psyllium and the short-chain organic acids derived from fiber breakdown, were assayed on isolated colonic epithelial cells primary-cultured from patients at high-risk of colon cancer, due to adenoma growth or family history of colon cancer. Psyllium fiber provided colonocytes some protection from deoxycholic acid-induced lysis. Propionic acid, a product of fiber breakdown, was a potent colonocyte mitogen, suggesting that fiber could indirectly protect the colon by providing colonocyte nutrients.
Friedman
E
E
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Lightdale
C
C
Winawer
S
S
D000328:Adult; D000368:Aged; D001706:Biopsy; D003106:Colon / Q000187:drug effects* / Q000473:pathology; D003840:Deoxycholic Acid; D004043:Dietary Fiber / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011620:Psyllium / Q000494:pharmacology*; D012307:Risk Factors
D004043:Dietary Fiber; D003840:Deoxycholic Acid; D011620:Psyllium