Luteinising hormone releasing hormone for incomplete descent of the testis.
Forty boys with 54 incompletely descended testes took part in a double blind, controlled trial of intranasal luteinising hormone releasing hormone. In the control (placebo) group of 18 boys there was no significant change in testicular descent and all required orchidopexy; in the 22 treated boys, however, 12 of 29 testes (42%) were found in a lower position. This study supports the idea that a trial of intranasal luteinising hormone releasing hormone (1200 micrograms/day for 28 days) will help clarify the need for orchidopexy in at least 30% of boys with incomplete descent of the testis, particularly those in whom the testes have emerged from the inguinal canal.
Klidjian
A M
AM
Swift
P G
PG
Johnstone
J M
JM
D000281:Administration, Intranasal; D002648:Child; D002986:Clinical Trials as Topic; D003456:Cryptorchidism / Q000188:drug therapy*; D004311:Double-Blind Method; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male
D007987:Gonadotropin-Releasing Hormone