The activities of 2,2',5,5'-tetrachlorobiphenyl, its 3,4-oxide metabolite, and 2,2',4,4'-tetrachlorobiphenyl in tumor induction and promotion assays.
Sensitive assays for the induction of lung adenomas in A/J mice or skin papillomas in SENCAR mice failed to show activity for either 2,2',5,5'-tetrachlorobiphenyl or 2,2',5,5'-tetrachlorobiphenyl 3,4-oxide. Injections of the 3,4-oxide into preweanling A/J mice caused considerable mortality, whereas the parent hydrocarbon did not. Both 2,2',5,5'- and 2,2',4,4'-tetrachlorobiphenyl showed promoting activity for hepatic gamma-glutamyl transpeptidase-positive foci initiated in rat liver by treatment with diethylnitrosamine. The promoting activity of 2,2',4,4'-tetrachlorobiphenyl was approximately 10-fold greater than that of the 2,2',5,5'-isomer.
Preston
B D
BD
Miller
E C
EC
Miller
J A
JA
D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010212:Papilloma / Q000139:chemically induced; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D051381:Rats; D012878:Skin Neoplasms / Q000139:chemically induced; D005723:gamma-Glutamyltransferase / Q000032:analysis
D002273:Carcinogens; C009407:2,5,2',5'-tetrachlorobiphenyl; C035976:2,4,2',4'-tetrachlorobiphenyl; C042328:2,2',5,5'-tetrachlorobiphenyl 3,4-oxide; D011078:Polychlorinated Biphenyls; D005723:gamma-Glutamyltransferase