Soluble extracts from a lymphoblastoid cell line modulate simian immunodeficiency syndrome (SAIDS) evolution.
Nineteen Macaca fascicularis monkeys were injected with SIV. They were subsequently divided into 5 groups. Four groups of 4 animals were injected with dialysable extracts (DLE) from a lymphoblastoid cell line which had been previously induced with DLE obtained either from the total lymphocyte population, or from the CD4 or CD8 subpopulations of mice immunized with SIV virus. The other three animals which constituted the control group received saline injections. The animals were kept under observation for a 108-day period, and the values of several biological parameters were compared in a multivariant statistical analysis. On the 108th day, the control group was significantly different from the other groups in the multivariant analysis. Furthermore, the CD4/CD8 ratio and the platelets and CD4 cell counts varied significantly between the groups in the univariant analysis. It is thus surmised that DLE obtained from CD8 cells or the total lymphocyte population of immunized animals may exert a modulating effect on the evolution of SAIDS.
Viza
D
D
Laboratoire d'Immunobiologie, Faculté de Médecine, Paris, France.
Vich
J M
JM
Minarro
A
A
Ablashi
D V
DV
Salahuddin
S Z
SZ
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D002460:Cell Line; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005455:Fluorescent Antibody Technique; D008214:Lymphocytes / Q000276:immunology*; D008252:Macaca fascicularis; D051379:Mice; D012192:Retroviridae Infections / Q000517:prevention & control*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000945:Antigens, Differentiation, T-Lymphocyte