title: Relative roles of genetic factors, dietary deficiency, and infection in anaemia in Vanuatu, South-West Pacific.
abstract: Hypochromic anaemia is very common among the island populations of Vanuatu in the South-West Pacific. Results of a large-scale survey show that, unexpectedly, this form of anaemia is seldom due to iron deficiency or coexistent parasitic disease. Rather, it results from a previously unsuspected high incidence of alpha-thalassaemia which has been identified only by application of DNA analysis to the populations studied. These findings suggest that hypochromic anaemia in tropical or subtropical populations should not necessarily be attributed to iron deficiency; detailed studies of iron status should be carried out before major dietary changes or fortification of food with iron are implemented.
authors.forename: D K
authors.initials: DK
authors.lastname: Bowden
authors.forename: A V
authors.initials: AV
authors.lastname: Hill
authors.forename: D R
authors.initials: DR
authors.lastname: Higgs
authors.forename: D J
authors.initials: DJ
authors.lastname: Weatherall
authors.forename: J B
authors.initials: JB
authors.lastname: Clegg
mesh_terms: D000293:Adolescent; D000328:Adult; D000747:Anemia, Hypochromic / Q000097:blood / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D002648:Child; D004247:DNA / Q000235:genetics; D004909:Erythrocyte Indices; D005260:Female; D006455:Hemoglobins, Abnormal / Q000032:analysis / Q000235:genetics; D006801:Humans; D000090463:Iron Deficiencies; D008297:Male; D010272:Parasitic Diseases / Q000150:complications*; D013789:Thalassemia / Q000150:complications / Q000175:diagnosis; D009514:Vanuatu
chemical_list: D006455:Hemoglobins, Abnormal; D004247:DNA