title: The action of LPS porins and peptidoglycan fragments on human spermatozoa.
abstract: This study examines the action of the cell wall components of enterobacteria on the vitality of human spermatozoa. Lipopolysaccharides extracted from Escherichia coli K12 killed about 80% of the spermatozoa at a concentration of 50 micrograms/ml. Porins extracted from E. coli, Proteus mirabilis and Salmonella typhimurium killed between 80% and 100% of the spermatozoa at a concentration of 50 micrograms/ml. Muramic acid and N-acetylmuramic acid caused about 60% mortality at a concentration of 50 micrograms/ml. The possibility that the products of cellular lysis in the course of gram-negative infections cause temporary sterility is discussed.
authors.affiliation: Istituto di Microbiologia, I Facoltà di Medicina e Chirurgia Università di Napoli.
authors.forename: F
authors.initials: F
authors.lastname: Galdiero
authors.forename: F
authors.initials: F
authors.lastname: Gorga
authors.forename: C
authors.initials: C
authors.lastname: Bentivoglio
authors.forename: R
authors.initials: R
authors.lastname: Mancuso
authors.forename: E
authors.initials: E
authors.lastname: Galdiero
authors.forename: M A
authors.initials: MA
authors.lastname: Tufano
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004926:Escherichia coli; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D010457:Peptidoglycan / Q000494:pharmacology*; D018272:Porins; D011513:Proteus mirabilis; D012486:Salmonella typhimurium; D013094:Spermatozoa / Q000187:drug effects*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D008070:Lipopolysaccharides; D010457:Peptidoglycan; D018272:Porins