title: Systemic ethanol: selective enhancement of responses to acetylcholine and somatostatin in hippocampus.
abstract: In rat hippocampal pyramidal cells tested in situ by iontophoresis of several neurotransmitters, ethanol significantly enhanced excitatory responses to acetylcholine and inhibitory responses to somatostatin-14 but had no statistically significant effect on excitatory responses to glutamate or inhibitory responses to gamma-aminobutyric acid or, in preliminary tests, to norepinephrine or serotonin. The effects of ethanol on responses to acetylcholine and somatostatin-14 may provide insight into synaptic mechanisms underlying the behavioral consequences of ethanol intoxication.
authors.forename: J R
authors.initials: JR
authors.lastname: Mancillas
authors.forename: G R
authors.initials: GR
authors.lastname: Siggins
authors.forename: F E
authors.initials: FE
authors.lastname: Bloom
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D006054:Goldfish; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology; D013004:Somatostatin / Q000494:pharmacology*; D013570:Synaptic Membranes / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D012701:Serotonin; D000431:Ethanol; D013004:Somatostatin; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine; D009638:Norepinephrine