[In vitro effect of pentoxifylline on the metabolism of glycogen and the secretory process in the parotid and lacrimal extraorbital glands in rats].
In the present work, we have shown that pentoxifylline (BL 191) and propentofylline (HW 285) penetrate very fast, without storage, in rat parotid and lacrimal gland cells. As phosphodiesterase inhibitor, pentoxifylline induces an increase of cAMP intracellular concentration. Pentoxifylline has a slight but sustained effect on 45Ca efflux and triggers a substantial labeled protein secretion and important glycogenolysis. Taken together, these data could be explained as a synergism between the different regulation routes involving calcium and cAMP.
Mauduit
P
P
Laboratoire de Biochimie des Transports Cellulaires (CNRS UA 1116), Université de Paris-Sud, Orsay, France.
Herman
G
G
Dreux
C
C
Rossignol
B
B
D000818:Animals; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism*; D007765:Lacrimal Apparatus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010306:Parotid Gland / Q000187:drug effects / Q000378:metabolism*; D010431:Pentoxifylline / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013805:Theobromine / Q000031:analogs & derivatives*; D014970:Xanthines / Q000494:pharmacology*
D011506:Proteins; D014970:Xanthines; C032114:propentofylline; D006003:Glycogen; D000242:Cyclic AMP; D013805:Theobromine; D010431:Pentoxifylline; D002118:Calcium
Effet in vitro de la pentoxifylline sur le métabolisme du glycogène et le processus sécrétoire dans les glandes parotides et lacrymales extraorbitaires de rat.