title: Myalgias and muscle contractures as the presenting signs of Addison's disease.
abstract: Severe generalized myalgias and muscle contractures of the lower extremities were the major initial manifestations of adrenal insufficiency in a 26 year old black male. The intensity of increased skin pigmentation was not fully appreciated until the patient's skin colour was compared to that of his brother. Replacement with physiological doses of gluco- and mineralocorticoids was associated with complete amelioration of symptomatology.
authors.affiliation: Department of Medicine C, Meir Hospital, Sapir Medicial Center, Kfar Sava, Israel.
authors.forename: M S
authors.initials: MS
authors.lastname: Shapiro
authors.forename: C
authors.initials: C
authors.lastname: Trebich
authors.forename: L
authors.initials: L
authors.lastname: Shilo
authors.forename: L
authors.initials: L
authors.lastname: Shenkman
mesh_terms: D000224:Addison Disease / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003286:Contracture / Q000209:etiology*; D006801:Humans; D008297:Male; D009135:Muscular Diseases / Q000209:etiology*; D010146:Pain / Q000209:etiology*
chemical_list: D000324:Adrenocorticotropic Hormone