Serum and liver enzyme changes in rats after short term exposure to dichlorvos.
Rat serum and liver ICDH, OCT, GOT and GPT activities are significantly elevated 2-6 hr after i.p. injections of single doses (2.5 mg/kg body wt) of dichlorvos. ICDH, OCT, GOT and GPT activities are significantly increased in serum and liver of rats receiving daily injections (0.25 mg/kg body wt) for 7 days. Although liver SD is significantly elevated in the single and repeated dosage study, serum SD appears unaffected at these levels of dichlorvos toxicity. Changes in serum OCT activity estimations maybe a useful single parameter for screening pesticides for potential hepatotoxic effects in humans and farm animals.
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D000818:Animals; D004006:Dichlorvos / Q000633:toxicity*; D004798:Enzymes / Q000097:blood / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D004798:Enzymes; D011506:Proteins; D004006:Dichlorvos