title: [Mutagenic activity of native and inactivated herpes simplex virus].
abstract: The mutagenic activity of native and inactivated herpes simplex virus (HSV-1) has been studied. The native HSV-1 strain has been shown to induce the gene mutations of 6-mercaptopurine resistance in Chinese hamster cells. The 1.5- to 2-fold decrease of mutagenic activity is due to HSV inactivation by thiophosphamide and formalin treatment. These data indicate the possibility of the given agents application for decreasing of the genetic danger of antiviral vaccine.
authors.forename: E L
authors.initials: EL
authors.lastname: Rubashevskiĭ
authors.forename: L L
authors.initials: LL
authors.lastname: Lukash
authors.forename: V S
authors.initials: VS
authors.lastname: Shved
authors.forename: V S
authors.initials: VS
authors.lastname: Mel'nichenko
authors.forename: L T
authors.initials: LT
authors.lastname: Tyl'vanchuk
mesh_terms: D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004352:Drug Resistance, Microbial / Q000235:genetics; D005557:Formaldehyde / Q000494:pharmacology; D006561:Herpes Simplex / Q000235:genetics / Q000382:microbiology; D015122:Mercaptopurine / Q000037:antagonists & inhibitors; D009154:Mutation; D018139:Simplexvirus / Q000187:drug effects / Q000235:genetics / Q000472:pathogenicity*; D013852:Thiotepa / Q000494:pharmacology; D014775:Virus Activation / Q000187:drug effects; D014776:Virus Cultivation / Q000379:methods
chemical_list: D005557:Formaldehyde; D013852:Thiotepa; D015122:Mercaptopurine
vernacular_title: Mutagennaia aktivnost' nativnogo i inaktivirovannogo virusa prostogo gerpesa.