Release of pancreatic secretory trypsin inhibitor from human hepatoblastoma cells on stimulation with cytokines.
To determine whether or not human pancreatic secretory trypsin inhibitor (PSTI) is an acute phase reactant released from hepatocytes, we investigated the effects of various cytokines on the release of PSTI from cultured human hepatoblastoma cells. PSTI was synthesized in human hepatoblastoma cells and released on stimulation with various cytokines: interleukin-1, tumor necrosis factor and interferon-beta.
Murata
A
A
Second Department of Surgery, Osaka University Medical School, Japan.
Ogawa
M
M
Uda
K
K
Matsuura
N
N
Watanabe
Y
Y
Baba
T
T
Mori
T
T
D001685:Biological Factors / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D016207:Cytokines; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D007375:Interleukin-1 / Q000494:pharmacology; D008113:Liver Neoplasms; D010179:Pancreas / Q000201:enzymology; D011994:Recombinant Proteins; D014361:Trypsin Inhibitors / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D001685:Biological Factors; D016207:Cytokines; D007370:Interferon Type I; D007375:Interleukin-1; D011994:Recombinant Proteins; D014361:Trypsin Inhibitors; D014409:Tumor Necrosis Factor-alpha