[Effect of chronic psychogenic stress on the characteristics of synaptic membrane receptors in the rat brain].
It has been shown that the 15-day stressing of rats by means of stochastic footshock combined with light flashes leads to a relatively stable "behavioral depression". Twenty-four hours after the last exposure to stress crude synaptosomes isolated from the whole brain demonstrated an increase in the KD of 3H-dihydroalprenolol specific binding and a lowering of the Bmax of 3H-WB-4101 specific binding sites. Specific binding of 3H-flunitrazepam changes inconclusively: the decrease in the KD is followed by a reduction in the concentration of receptors. Specific binding of 3H-imipramine by brain membranes remains unchanged under the above conditions.
Nikuradze
V O
VO
Rozhanets
V V
VV
Kozlovskaia
M M
MM
Val'dman
A V
AV
D000317:Adrenergic alpha-Antagonists / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004082:Dihydroalprenolol / Q000378:metabolism; D004146:Dioxanes / Q000378:metabolism; D005445:Flunitrazepam / Q000378:metabolism; D007099:Imipramine / Q000378:metabolism; D008297:Male; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013315:Stress, Psychological / Q000378:metabolism*
D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D017981:Receptors, Neurotransmitter; D004082:Dihydroalprenolol; D005445:Flunitrazepam; C010654:(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane; D007099:Imipramine
Vliianie khronicheskogo psikhogennogo stressa na kharakteristiki nekotorykh retseptorov sinapticheskikh membran golovnogo mozga krys.