Activity of beta-kainic acid on neocortical neurons in vivo and hippocampal neurons in vitro.
The beta-isomer of kainic acid has been reported to have anticonvulsant activity with a profile suggesting amino acid antagonism. The present study, on neurons in the cerebral cortex of anaesthetised rats or in hippocampal slices, shows that beta-kainate does not antagonise any of the major agonists at amino acid receptors: N-methylaspartate, quisqualic acid or alpha-kainic acid. beta-Kainate does have an excitant action of its own which can be partially reduced by 2-amino-5-phosphonovaleric acid but is unaffected by gamma-D-glutamylglycine. It is blocked completely by kynurenic acid.
Stone
T W
TW
Collins
J F
JF
D015763:2-Amino-5-phosphonovalerate; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D004151:Dipeptides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007478:Iontophoresis; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D016202:N-Methylaspartate; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
D004151:Dipeptides; D017981:Receptors, Neurotransmitter; C028929:gamma-glutamylglycine; D001224:Aspartic Acid; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; D014633:Valine; D007608:Kainic Acid