Search for I-A trans-complementation affecting the anti-thy-1 response in mice: a final report.
Twenty-nine different F1 hybrids were tested for the possible effect of the H-2 (I-A) heterozygosity purportedly mediated by I-A trans-complementation, on the magnitude of the anti-Thy-1 response. Although the hybrids tested responded well to immunization with Thy-1 disparate thymocytes from donors H-2 compatible with one of the parents they responded poorly when immunized with thymocytes from donors H-2 incompatible with both parents. Preliminary data suggest that H-2 heterozygosity may exert a small but definite effect in H-2r/H-2f hybrids.
Quackenbush
L J
LJ
Dowjat
W K
WK
Zaleski
M B
MB
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology*; D005260:Female; D005816:Genetic Complementation Test; D006183:H-2 Antigens / Q000235:genetics*; D006579:Heterozygote; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006824:Hybridization, Genetic; D007518:Isoantibodies / Q000235:genetics / Q000276:immunology*; D008297:Male; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II; D007518:Isoantibodies; D018800:Thy-1 Antigens