title: Inhibition of human lymphocyte cyclic nucleotide phosphodiesterases by the chlorinated adenosine analog DTA-35.
abstract: Human (E+)-T-lymphocytes have multiple cyclic nucleotide phosphodiesterase activities, some of which are markedly inhibited by the chlorinated adenosine derivative 9-(3',5'-dichloro-2',3',5'-trideoxy-beta-D-threo-pentofuranosyl)adenine (DTA-35).
authors.affiliation: Department of Biochemistry, University of Minnesota, Minneapolis 55455.
authors.forename: M Y
authors.initials: MY
authors.lastname: Hurwitz
authors.forename: R L
authors.initials: RL
authors.lastname: Hurwitz
authors.forename: R D
authors.initials: RD
authors.lastname: Edstrom
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D003839:Deoxyadenosines / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000201:enzymology* / Q000276:immunology
chemical_list: D003839:Deoxyadenosines; C059947:DTA 35; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D015106:3',5'-Cyclic-GMP Phosphodiesterases