Regional difference in sympathetic vasoconstrictor tone in conscious rats.
Regional differences in sympathetic vasoconstrictor tone were studied in conscious rats. In each rat an electromagnetic flow probe was chronically implanted around the common carotid, superior mesenteric, or renal artery, or the terminal aorta. An indwelling catheter for the measurement of arterial pressure was inserted into the terminal aorta via the right femoral artery. Peripheral resistance was calculated by dividing arterial pressure by flow. The per cent decrease in peripheral resistance on the ganglion blockade with hexamethonium bromide was used as a measure of regional sympathetic vasoconstrictor tone. A significant decrease in peripheral resistance, assumed to indicate a substantial tonic discharge to resistance vessels, was observed in conscious rats only in the carotid and renal areas and not in the superior mesenteric and hindquarter (supplied by the terminal aorta) areas. Since ganglion blockade also diminished the sum of the mean regional flows, cardiac output was estimated to decrease on the ganglion blockade. This suggests that capacitance vessels are also receiving a sizable vasoconstrictor tone, because the ganglion blockade did not elevate right atrial pressure. Pentobarbital anesthesia markedly inhibited the assumed tone to the renal area and was estimated to newly generate a tone to the hindquarters.
Iriuchijima
J
J
Sakata
S
S
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001011:Aorta / Q000294:innervation; D001158:Arteries / Q000294:innervation*; D001794:Blood Pressure / Q000187:drug effects; D002339:Carotid Arteries / Q000294:innervation; D002395:Catecholamines / Q000097:blood; D003714:Denervation; D005260:Female; D005263:Femoral Artery / Q000294:innervation; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008297:Male; D008638:Mesenteric Arteries / Q000294:innervation; D009200:Myocardial Contraction; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D012077:Renal Artery / Q000294:innervation; D013564:Sympathetic Nervous System / Q000502:physiology*; D014661:Vasoconstriction / Q000187:drug effects
D000959:Antihypertensive Agents; D002395:Catecholamines; D006584:Hexamethonium Compounds; D018738:Hexamethonium