title: Infectious mononucleosis mimicking a B cell immunoblastic lymphoma associated with an abnormality in regulatory T cells.
abstract: An elderly woman is described with infectious mononucleosis in whom cervical node biopsy was interpreted as showing immunoblastic lymphoma. Concomitant reactive lymphocytosis, Epstein-Barr virus serologic results consistent with an acute infection, and demonstration of polyclonal B cell infiltration of other tissues argued against intervention. Defective in vitro T cell responses were demonstrated during the acute phase of Epstein-Barr virus infection. Infectious mononucleosis has rarely been reported as mimicking a non-Hodgkin's lymphoma. At 18 months, our patient's course has been typical for infectious mononucleosis with no evidence of disseminated malignancy.
authors.forename: L A
authors.initials: LA
authors.lastname: Otteman
authors.forename: P R
authors.initials: PR
authors.lastname: Greipp
authors.forename: G J
authors.initials: GJ
authors.lastname: Ruiz-Argüelles
authors.forename: P M
authors.initials: PM
authors.lastname: Banks
authors.forename: C Y
authors.initials: CY
authors.lastname: Li
authors.forename: J A
authors.initials: JA
authors.lastname: Katzmann
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007244:Infectious Mononucleosis / Q000175:diagnosis* / Q000473:pathology; D007958:Leukocyte Count; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology