Interferon gamma does not induce antiviral resistance in T lymphocytes.
We compared the activity of human recombinant alpha and gamma interferons (IFNs) on normal T lymphocytes and various T cell lines. IFN gamma, unlike IFN alpha, did not promote the antiviral state in these cells, or induce the activity of 2'-5' oligoadenylate synthetase. The lack of antiviral effect was observed using an RNA virus (VSV) and a DNA virus (HSV, type 1) as challenger viruses.
Zucca
M
M
Institute of Microbiology, University, Torino, Italy.
Gribaudo
G
G
Ferrara
B
B
Cavallo
G
G
Landolfo
S
S
D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism; D015153:Blotting, Western; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology; D011994:Recombinant Proteins; D018139:Simplexvirus; D013601:T-Lymphocytes / Q000276:immunology*; D014407:Tumor Cells, Cultured; D014721:Vesicular stomatitis Indiana virus
D007370:Interferon Type I; D007376:Interleukin-2; D011994:Recombinant Proteins; D007371:Interferon-gamma; D015088:2',5'-Oligoadenylate Synthetase