title: Aluminosilicates and senile plaque formation in Alzheimer's disease.
abstract: Aluminium and silicon were found to be colocalised in the central region of senile plaque cores in studies with energy dispersive X-ray microanalysis. The distribution of these elements was similar in cores isolated from the cerebral cortex of patients with senile dementia of the Alzheimer type and in cores studied in situ from tissue sections from the cerebral cortex of presenile and senile patients with Alzheimer's disease, and elderly, mentally normal patients. High-resolution solid-state nuclear magnetic resonance techniques showed aluminium and silicon to be present as aluminosilicates. The presence of aluminosilicates at the centre of senile plaque cores contrasts with the distribution of other inorganic constituents and suggests that they may be involved in the initiation or early stages of senile plaque formation.
authors.forename: J M
authors.initials: JM
authors.lastname: Candy
authors.forename: A E
authors.initials: AE
authors.lastname: Oakley
authors.forename: J
authors.initials: J
authors.lastname: Klinowski
authors.forename: T A
authors.initials: TA
authors.lastname: Carpenter
authors.forename: R H
authors.initials: RH
authors.lastname: Perry
authors.forename: J R
authors.initials: JR
authors.lastname: Atack
authors.forename: E K
authors.initials: EK
authors.lastname: Perry
authors.forename: G
authors.initials: G
authors.lastname: Blessed
authors.forename: A
authors.initials: A
authors.lastname: Fairbairn
authors.forename: J A
authors.initials: JA
authors.lastname: Edwardson
mesh_terms: D000368:Aged; D000538:Aluminum Silicates / Q000032:analysis*; D000544:Alzheimer Disease / Q000473:pathology*; D000682:Amyloid / Q000032:analysis; D002540:Cerebral Cortex / Q000032:analysis* / Q000648:ultrastructure; D006801:Humans; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000538:Aluminum Silicates; D000682:Amyloid