title: Tumor location and drug targeting using a monoclonal antibody (anti-SSEA-1) and antigen-binding fragments.
abstract: Both murine and heterotransplanted human nonseminomatous germ-cell tumors have been successfully located by external scintigraphy using radioiodinated anti-SSEA-1, a monoclonal IgM, and its pepsin-derived antigen-binding fragment, F(ab')2 mu. Antibody localization in the tumor is mainly due to antigenic specificity, rather than to nonspecific trapping, and depends strongly on the amount of time after injection. The antibody has been used for drug targeting in vitro and in vivo.
authors.forename: B
authors.initials: B
authors.lastname: Ballou
authors.forename: J M
authors.initials: JM
authors.lastname: Reiland
authors.forename: G
authors.initials: G
authors.lastname: Levine
authors.forename: R J
authors.initials: RJ
authors.lastname: Taylor
authors.forename: W C
authors.initials: WC
authors.lastname: Shen
authors.forename: H J
authors.initials: HJ
authors.lastname: Ryser
authors.forename: D
authors.initials: D
authors.lastname: Solter
authors.forename: T R
authors.initials: TR
authors.lastname: Hakala
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000276:immunology*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002822:Choriocarcinoma / Q000000981:diagnostic imaging; D005260:Female; D006017:Glycolipids / Q000276:immunology*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D007457:Iodine Radioisotopes; D016256:Lewis X Antigen; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging*; D011247:Pregnancy; D011877:Radionuclide Imaging; D013724:Teratoma / Q000000981:diagnostic imaging; D014183:Transplantation, Heterologous
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; D006017:Glycolipids; D007140:Immunoglobulin Fab Fragments; D007457:Iodine Radioisotopes; D016256:Lewis X Antigen