title: Protection of microvasculature in rat brain against late radiation injury by gammaphos.
abstract: The ability of the radioprotector gammaphos to modify the development of late vascular changes in rat brain after local irradiation with 25 Gy was investigated by means of angiographic method. A protective effect was seen against late vascular abnormalities. It is suggested that a causative relationship exists between vascular abnormalities, brain necrosis, and radiation mortality after irradiation with moderate doses.
authors.affiliation: Institute of Biological Physics, Academy of Sciences of the USSR, Pushchino, Moscow Region.
authors.forename: E D
authors.initials: ED
authors.lastname: Plotnikova
authors.forename: M K
authors.initials: MK
authors.lastname: Levitman
authors.forename: V V
authors.initials: VV
authors.lastname: Shaposhnikova
authors.forename: J V
authors.initials: JV
authors.lastname: Koshevoj
authors.forename: L K
authors.initials: LK
authors.lastname: Eidus
mesh_terms: D004999:Amifostine / Q000627:therapeutic use*; D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000528:radiation effects; D008833:Microcirculation / Q000187:drug effects / Q000528:radiation effects*; D009946:Organothiophosphorus Compounds / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D009946:Organothiophosphorus Compounds; D011837:Radiation-Protective Agents; D004999:Amifostine