Taxol effects on glia in organotypic mouse spinal cord-DRG cultures.
Exposure of organotypic mouse spinal cord-dorsal root ganglion cultures to 1-2 microM taxol for up to 6 days results in a remarkable increase in cytoplasmic microtubules in differentiated oligodendroglia. In contrast, there is a notably smaller change in the microtubule complement of astroglia. This suggests that the regulatory and/or synthetic systems for tubulin in these glial types may differ, and that oligodendroglia appear more responsive to modulation in the levels of tubulin subunits as a result of the action of taxol.
Masurovsky
E B
EB
Peterson
E R
ER
Crain
S M
SM
Horwitz
S B
SB
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001253:Astrocytes / Q000648:ultrastructure; D005727:Ganglia, Spinal / Q000187:drug effects* / Q000648:ultrastructure; D051379:Mice; D008870:Microtubules / Q000648:ultrastructure; D009457:Neuroglia / Q000187:drug effects* / Q000648:ultrastructure; D009924:Organ Culture Techniques; D017239:Paclitaxel; D013116:Spinal Cord / Q000187:drug effects* / Q000648:ultrastructure; D013997:Time Factors
D000470:Alkaloids; D017239:Paclitaxel