Decreased neurotransmitter receptor binding in striatum and cortex from adult hypothyroid rats.
The consequences of propylthiouracil-induced thyroid deficiency on pre- and postsynaptic biochemical markers in the corpus striatum and the visual cortex were investigated in adult rats. Hypothyroidism in adult rats significantly impaired (by 30%) striatal [3H]spiroperidol binding capacity. In the visual cortex, small but significant reductions in [3H]WB.4101 and in [3H]muscimol binding were evident, whereas glutamate decarboxylase activity was increased by 18% in the thyroid-deficient rats. Compatible with previous morphological evidence (Ruiz-Marcos et al.), the present observations may imply alterations in dendritic morphology of neurones in the striatum and cortex during long-term hypothyroidism in adult rats. However, the molecular changes observed suggest a differential sensitivity of transmitter-specific neurones in the central nervous system to thyroid hormone.
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D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D004146:Dioxanes / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism; D007037:Hypothyroidism / Q000378:metabolism*; D009118:Muscimol / Q000378:metabolism; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D014793:Visual Cortex / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D004146:Dioxanes; D017981:Receptors, Neurotransmitter; D009118:Muscimol; D013134:Spiperone; D005680:gamma-Aminobutyric Acid; D011813:Quinuclidinyl Benzilate; C010654:(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane; D014446:Tyrosine 3-Monooxygenase; D002795:Choline O-Acetyltransferase; D005968:Glutamate Decarboxylase