Taurine modulates glycine response in Xenopus oocytes injected with messenger RNA from mouse brain.
The modulatory action of taurine on the glycine response was investigated in Xenopus oocytes injected with messenger RNA from mouse brainstem under voltage-clamped condition. Taurine competitively inhibited the glycine response in a dose-dependent manner. This inhibition was insensitive to bicuculline and intracellularly injected EGTA. The results suggest that taurine could directly modulate glycinergic neurotransmission in the central nervous system.
Horikoshi
T
T
Department of Physiology, School of Dental Medicine, Tsurumi University, Yokohama, Japan.
Asanuma
A
A
Yanagisawa
K
K
Goto
S
S
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D018118:Chloride Channels; D002712:Chlorides / Q000378:metabolism / Q000502:physiology; D005260:Female; D005998:Glycine / Q000494:pharmacology; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology; D051379:Mice; D009865:Oocytes / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D018009:Receptors, Glycine; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D013654:Taurine / Q000494:pharmacology*; D014982:Xenopus laevis
D018118:Chloride Channels; D002712:Chlorides; D008565:Membrane Proteins; D012333:RNA, Messenger; D018009:Receptors, Glycine; D017981:Receptors, Neurotransmitter; D013654:Taurine; D005998:Glycine