title: The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization.
abstract: The Na+/H+ antiporter is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells. We cloned the human gene capable of complementing antiporter-deficient mouse fibroblasts and isolated an exon-containing genomic DNA fragment. Using this genomic probe, we mapped the putative structural gene of the amiloride-sensitive Na+/H+ antiporter to the human chromosome region 1p35----p36.1 by in situ hybridization.
authors.affiliation: INSERM U242, Centre de Génétique Médicale, Hôpital d'enfants de la Timone, Marseille, France.
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: C
authors.initials: C
authors.lastname: Sardet
authors.forename: A
authors.initials: A
authors.lastname: Franchi
authors.forename: J
authors.initials: J
authors.lastname: Pouysségur
mesh_terms: D002352:Carrier Proteins / Q000235:genetics*; D002478:Cells, Cultured; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D005347:Fibroblasts; D005796:Genes; D006801:Humans; D008677:Metaphase; D009693:Nucleic Acid Hybridization; D017923:Sodium-Hydrogen Exchangers; D014162:Transfection
chemical_list: D002352:Carrier Proteins; D015342:DNA Probes; D017923:Sodium-Hydrogen Exchangers; D004247:DNA