title: Lisuride infusion pump: a device for the treatment of motor fluctuations in Parkinson's disease.
abstract: Intravenous levodopa or lisuride infusions can successfully reduce daily motor fluctuations in Parkinson's disease, which indicates adequate striatal dopaminergic mechanisms even in severe cases. In 3 patients who received continuous subcutaneous administration of lisuride, by means of a portable mini-infusion pump, in addition to oral levodopa plus decarboxylase inhibitor, mobility improved considerably and "off" periods were reduced or abolished. This response was maintained for 4 to 7 months without toxic side-effects, but increased dyskinetic movements were observed. All 3 patients were discharged and have been able to live independently during the months on treatment. These results suggest that continuous dopaminergic stimulation with the use of a portable delivery system can be a practical therapeutic tool in parkinsonian patients with complicated motor fluctuations.
authors.forename: J A
authors.initials: JA
authors.lastname: Obeso
authors.forename: M R
authors.initials: MR
authors.lastname: Luquin
authors.forename: J M
authors.initials: JM
authors.lastname: Martínez-Lage
mesh_terms: D004873:Ergolines / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral / Q000295:instrumentation; D007279:Injections, Subcutaneous / Q000295:instrumentation; D008090:Lisuride / Q000008:administration & dosage*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009069:Movement Disorders / Q000188:drug therapy*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D004873:Ergolines; D008090:Lisuride