title: Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo.
abstract: There are two genes related to the viral erbB gene in the human genome. c-erbB-1 is the same as the gene for the epithelial-growth-factor (EGF) receptor, and c-erbB-2 encodes a receptor-like protein very similar to, but distinct from, the EGF receptor. Hybridisation analysis of DNA from 101 fresh human malignant tumours showed that the c-erbB-2 gene was amplified in 5 of 63 adenocarcinomas and none of 38 other types of tumours, whereas the c-erbB-1/EGF-receptor gene was amplified only in 1 of 8 squamous-cell carcinomas. Thus, the protein products of the amplified c-erbB-2 gene may have a role in the evolution of adenocarcinomas, as does the EGF receptor in some squamous-cell carcinomas.
authors.forename: J
authors.initials: J
authors.lastname: Yokota
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Toyoshima
authors.forename: M
authors.initials: M
authors.lastname: Terada
authors.forename: T
authors.initials: T
authors.lastname: Sugimura
authors.forename: H
authors.initials: H
authors.lastname: Battifora
authors.forename: M J
authors.initials: MJ
authors.lastname: Cline
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics; D004279:DNA, Viral / Q000032:analysis; D066246:ErbB Receptors; D005784:Gene Amplification; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics; D009693:Nucleic Acid Hybridization; D011518:Proto-Oncogene Proteins / Q000032:analysis; D011519:Proto-Oncogenes; D011956:Receptors, Cell Surface / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics
chemical_list: D004279:DNA, Viral; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D066246:ErbB Receptors