Effect of Clostridium perfringens alpha toxin on the isolated rat vas deferens.
Alpha toxin produced by Clostridium perfringens potentiated norepinephrine-evoked contraction in the isolated rat vas deferens, but itself caused no contraction within 60 min. The potentiating activity was dependent on the dose of the toxin and was quantitatively related to the phospholipase C activity of the toxin preparation.
Sakurai
J
J
Nomura
S
S
Fujii
Y
Y
Oshita
Y
Y
D000818:Animals; D001427:Bacterial Toxins / Q000032:analysis / Q000494:pharmacology*; D002135:Calcium-Binding Proteins; D003016:Clostridium perfringens; D004357:Drug Synergism; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D010738:Type C Phospholipases / Q000032:analysis; D014649:Vas Deferens / Q000187:drug effects
D001427:Bacterial Toxins; D002135:Calcium-Binding Proteins; D010738:Type C Phospholipases; C040649:alpha toxin, Clostridium perfringens; D009638:Norepinephrine