Effects of extracellular egg factors on sperm guanylate cyclase.
Extracellular factors from the sea urchin egg induce a change in the electrophoretic mobility of an abundant sperm membrane phosphoprotein. The modified protein was identified as guanylate cyclase. The mobility shift of the cyclase was shown to be associated with a decrease in its enzymatic activity.
Ward
G E
GE
Garbers
D L
DL
Vacquier
V D
VD
D000818:Animals; D004789:Enzyme Activation; D005260:Female; D005306:Fertilization; D006162:Guanylate Cyclase / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008970:Molecular Weight; D010750:Phosphoproteins / Q000378:metabolism; D012617:Sea Urchins; D013079:Sperm Maturation; D013084:Sperm-Ovum Interactions; D013094:Spermatozoa / Q000201:enzymology*
D008565:Membrane Proteins; D010750:Phosphoproteins; D006162:Guanylate Cyclase