Tardive dyskinesia in young mentally retarded individuals.
The results of a systematic neuroleptic withdrawal study in 38 mentally retarded children, adolescents, and young adults are described. The focus of the study was the occurrence of side effects of chronic neuroleptic treatment: tardive dyskinesia, transient withdrawal dyskinesia, nondyskinetic withdrawal symptoms, and a possible behavioral analogue of withdrawal dyskinesia. Transient side effects were noted in 34% of the subjects, and tardive dyskinesia in an equal proportion. The data suggest that cumulative neuroleptic dose may play a role as a risk factor in the development of severe tardive dyskinesia.
Gualtieri
C T
CT
Schroeder
S R
SR
Hicks
R E
RE
Quade
D
D
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D002648:Child; D004305:Dose-Response Relationship, Drug; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D007361:Intelligence Tests; D008297:Male; D008875:Middle Aged; D012306:Risk; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000209:etiology*
D014150:Antipsychotic Agents