Progress toward resolving the possible linkage of multiple endocrine neoplasia type 2A to haptoglobin and group-specific loci: use of restriction fragment length polymorphisms extends exclusion region.
In an earlier paper, positive but nonsignificant lod scores were found in pair-wise linkage tests between multiple endocrine neoplasia type 2A (MEN-2A) and both the haptoglobin (HP) locus on chromosome 16 and group-specific component (GC) locus on chromosome 4. Recently discovered restriction fragment length polymorphisms for HP and for metallothionein 2 processed pseudogene 1 (MT2P1) near GC have made it possible to carry out a more powerful set of linkage tests with MEN-2A. This paper reports the results of such linkage analyses employing both pair-wise and multipoint tests. Close linkage of HP on chromosome 16 and MEN-2A is excluded. Linkage of MEN-2A on chromosome 4 with GC is excluded on the MT2P1 side of GC in a 7-centimorgan interval around MT2P1.
Kidd
K K
KK
Kidd
J R
JR
Castiglione
C M
CM
Pakstis
A J
AJ
Sparkes
R S
RS
D001797:Blood Protein Electrophoresis; D002874:Chromosome Mapping; D002902:Chromosomes, Human, 16-18; D002905:Chromosomes, Human, 4-5; D004262:DNA Restriction Enzymes; D005819:Genetic Markers; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D009377:Multiple Endocrine Neoplasia / Q000235:genetics*; D011110:Polymorphism, Genetic; D014809:Vitamin D-Binding Protein / Q000235:genetics*
D005819:Genetic Markers; D006242:Haptoglobins; D014809:Vitamin D-Binding Protein; D004262:DNA Restriction Enzymes