title: Synthesis and beta-adrenoceptor blocking activity of thiophenic analogues of metoprolol.
abstract: The synthesis of the thiophenic analogue of metoprolol (VI) and of its related compound (VII) are described. Except for cardioselectivity at low doses, the thiophenic analogue of metoprolol behaves in a very similar way as this compound in all the aspects considered in a preliminary pharmacological study.
authors.forename: S
authors.initials: S
authors.lastname: Conde
authors.forename: C
authors.initials: C
authors.lastname: Corral
authors.lastname: Lissavetzky
authors.forename: V
authors.initials: V
authors.lastname: Darias
authors.forename: D
authors.initials: D
authors.lastname: Martin
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis*; D000779:Anesthetics, Local; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007928:Lethal Dose 50; D008297:Male; D008790:Metoprolol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000319:Adrenergic beta-Antagonists; D000779:Anesthetics, Local; D008790:Metoprolol