title: Gene dosage studies regionally assign the phosphoserine phosphatase gene to 7p15.1 or 2.
abstract: Gene dosage studies in subjects with imbalances of the short arm of chromosome 7 have suggested the localization of the phosphoserine phosphatase (PSP) structural gene to p22.1----pter or p15----p21.2. We have found normal enzyme activity in the fibroblasts from a patient with dup (7) (p15.3----pter). This result refines the assignment of the PSP gene to the 7p15.1----p15.2 sub-bands.
authors.affiliation: Dipartimento di Sanità Pubblica e Biologica Cellulare, II Università di Roma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Novelli
authors.forename: B
authors.initials: B
authors.lastname: Dallapiccola
mesh_terms: D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D002897:Chromosomes, Human, Pair 7; D005347:Fibroblasts / Q000201:enzymology; D005796:Genes; D006801:Humans; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D010744:Phosphoric Monoester Hydrolases; C022394:phosphoserine phosphatase