title: Multiple forms of somatostatin-like immunoreactivity are not influenced by cholinergic denervation of rat hippocampus.
abstract: Hippocampal choline acetyltransferase was reduced by 89% in rats two weeks after electrolytic lesion of the septum. The hippocampal concentrations of somatostatin (SOM)-14, SOM-28 and high-molecular-weight SOM were unaltered, suggesting that the activity of hippocampal SOM neurones is not influenced by cholinergic afferents. The relevance of this finding to Alzheimer-type dementia and Down's syndrome is discussed.
authors.forename: A R
authors.initials: AR
authors.lastname: Pierotti
authors.forename: J
authors.initials: J
authors.lastname: Simpson
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003714:Denervation; D004314:Down Syndrome / Q000378:metabolism; D006624:Hippocampus / Q000201:enzymology / Q000276:immunology* / Q000502:physiology; D008297:Male; D010275:Parasympathetic Nervous System / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000276:immunology* / Q000378:metabolism
chemical_list: D013004:Somatostatin; D002795:Choline O-Acetyltransferase