[Role of histamine as an intermediary in the action of estradiol on the rat uterus: inhibition of the hormonal induction of enzymes using histamine antagonists].
The administration of methiamide, a blocker of histamine H2-receptors, to rats was shown to prevent the induction of hexokinase (HK) and glucose-6-phosphate dehydrogenase (G-6PD) caused by both histamine and estradiol. An inhibitory effect of methiamide remained stable up to 16 h after histamine and estradiol administration. Diphenhydramine, a blocker of histamine H1-receptors, produces a short-term inhibitory effect on the HK and G-6PD activity stimulated by histamine and estradiol. The short-term nature of the diphenhydramine effect may be attributed to a low affinity to histamine H2-receptors and histamine fast dissociation. It may be concluded that some of the estradiol effects, particularly the HK and G-6PD induction in the uterus are histamine-mediated, apparently by means of H2-receptors. The administration of histamine to rats increases the uterus mass causing its inundation, and H1- and H2-blockers prevent this effect of histamine. However, the above histamine antagonists do not inhibit uterus inundation caused by estradiol. A conclusion is made that estradiol stimulates the uterus inundation not only by means of histamine but also by some other means.
Pankova
T G
TG
Igonina
T M
TM
Salganik
R I
RI
D000818:Animals; D004155:Diphenhydramine / Q000494:pharmacology; D004790:Enzyme Induction; D004958:Estradiol / Q000502:physiology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000096:biosynthesis*; D006593:Hexokinase / Q000096:biosynthesis*; D006632:Histamine / Q000502:physiology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D008785:Metiamide / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000187:drug effects / Q000201:enzymology*
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D008785:Metiamide; D004958:Estradiol; D006632:Histamine; D004155:Diphenhydramine; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase
Rol' gistamina kak posrednika v deĭstvii éstradiola ma matku krys: tormozhenie gormonal'noĭ induktsii fermentov s pomoshch'iu antagonistov histamina.