title: Lymphatic transport of sodium cefoxitin in the presence of sodium 5-methoxysalicylate after injection into rat rectal connective tissue, femoral muscle and femoral vein.
abstract: Lymphatic uptake of sodium cefoxitin after injection into rectal connective tissue was greater than after injection into the femoral muscle of rats. Coadministration with sodium 5-methoxysalicylate enhanced lymphatic drug uptake at both sites. This enhancement may be an indirect result of 5-methoxysalicylate's suppression of vascular permeation of the cefoxitin. An adjuvant-induced increase in lymphatic fluid flow may also be partially involved in the enhancement of cefoxitin lymphatic transport.
authors.forename: T
authors.initials: T
authors.lastname: Nishihata
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.forename: A
authors.initials: A
authors.lastname: Kamada
authors.forename: G
authors.initials: G
authors.lastname: Frederick
authors.forename: M
authors.initials: M
authors.lastname: Dillsaver
authors.forename: T
authors.initials: T
authors.lastname: Higuchi
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D002440:Cefoxitin / Q000097:blood / Q000378:metabolism*; D003238:Connective Tissue / Q000378:metabolism*; D062425:Hydroxybenzoate Ethers; D008208:Lymphatic System / Q000378:metabolism*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012007:Rectum / Q000378:metabolism; D012459:Salicylates / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D062425:Hydroxybenzoate Ethers; D012459:Salicylates; C033304:5-methoxysalicylic acid; D002440:Cefoxitin