Age related decline in functional T cell subsets in the mouse.
The changes of two functions of regulatory T cells in mice of different ages were determined. Mice were immunized with SRBC. DTH responsiveness of spleen cells and the production of IL-2 after Concanavalin A stimulation of the same cell suspension was measured. Cell populations were analysed for expression of Lyt-2 and Thy-1 surface markers. The relationship between DTH responsiveness and T cell subset distribution in peripheral blood was analysed. A direct relationship between age related changes in DTH responsiveness and T cell subset distributions in peripheral blood was observed in most individual animals.
Boersma
W J
WJ
Vissinga
C S
CS
D000367:Age Factors; D000818:Animals; D000950:Antigens, Ly / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D003208:Concanavalin A / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology / Q000502:physiology*; D018800:Thy-1 Antigens
D000950:Antigens, Ly; D000954:Antigens, Surface; D007376:Interleukin-2; D018800:Thy-1 Antigens; D003208:Concanavalin A