Sodium deprivation increases the antinociceptive activity of morphine.
In rats maintained for 50 days on a low-sodium diet and with a compensatory hyperactivity of the renin-angiotensin system, the antinociceptive activity of morphine was significantly longer-lasting than in controls. It is suggested that the renin-angiotensin system modulates opioid system responsivity.
Poggioli
R
R
Vergoni
A V
AV
Bertolini
A
A
D000700:Analgesics; D000818:Animals; D004039:Diet, Sodium-Restricted; D009020:Morphine / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects; D012684:Sensory Thresholds / Q000187:drug effects
D000700:Analgesics; D009020:Morphine