Field trial of oral cholera vaccines in Bangladesh.
The protective efficacy of oral B subunit killed whole-cell (BS-WC) and killed whole-cell (WC) cholera vaccines was assessed in 63 498 Bangladeshi children aged 2-15 years and women aged over 15 years. Each received three doses of BS-WC, WC, or placebo in a randomised, double-blinded fashion. Surveillance for cases seeking medical care up to six months after the third dose revealed 26 cases of confirmed cholera in the placebo group, 4 cases in the BS-WC group (protective efficacy 85%; p less than 0.0001), and 11 cases in the WC group (protective efficacy 58%; p less than 0.01). For each vaccine protective efficacy was consistent in different age-groups (2-10 years versus greater than 10 years) and for different severities of cholera.
Clemens
J D
JD
Sack
D A
DA
Harris
J R
JR
Chakraborty
J
J
Khan
M R
MR
Stanton
B F
BF
Kay
B A
BA
Khan
M U
MU
Yunus
M
M
Atkinson
W
W
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001459:Bangladesh; D002648:Child; D002675:Child, Preschool; D002771:Cholera / Q000517:prevention & control*; D022121:Cholera Vaccines / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D011897:Random Allocation; D014611:Vaccination
D022121:Cholera Vaccines