An excitatory amino acid projection from rat prefrontal cortex to periaqueductal gray.
High affinity D-[3H]aspartate and [3H]GABA uptake, and amino acid concentrations were examined in synaptosome-enriched preparations of rat periaqueductal gray matter 6-7 days following N-methyl-D-aspartate lesions confined to medial prefrontal cortex. Specific reductions were observed in the high affinity uptake of D-[3H]aspartate (78% of control, p less than 0.025), but not of [3H]GABA. Concentrations of glutamate, aspartate, GABA, glycine and alanine were not significantly reduced in lesioned animals. These results suggest the presence of glutamatergic and/or aspartatergic projections from medial prefrontal cortex to periaqueductal grey matter.
Christie
M J
MJ
James
L B
LB
Beart
P M
PM
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D005625:Frontal Lobe / Q000033:anatomy & histology* / Q000473:pathology; D005971:Glutamates; D018698:Glutamic Acid; D008297:Male; D016202:N-Methylaspartate; D009336:Necrosis; D018377:Neurotransmitter Agents; D010487:Periaqueductal Gray / Q000033:anatomy & histology* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000378:metabolism
D005971:Glutamates; D018377:Neurotransmitter Agents; D001224:Aspartic Acid; D018698:Glutamic Acid; D016202:N-Methylaspartate