Concomitant suppression of plasma ACTH- and beta-endorphin-like immunoreactivity by cyproheptadine, naloxone, and somatostatin in the ectopic ACTH syndrome.
Release of plasma ACTH- and beta-endorphin (beta-EP)-like immunoreactivity (LI) was studied in vivo in a patient with an ectopic ACTH-producing malignant thymoma. Administration of lysin vasopressin stimulated concomitant release of plasma ACTH- and beta-EP-LI. Administration of cyproheptadine, naloxone, and somatostatin significantly suppressed plasma levels of ACTH- and beta-EP-LI, while saline infusion did not. Gel exclusion chromatography of the plasma extracts revealed that ACTH-LI consisted of two components, large and small molecular weight form, while beta-EP-LI consisted of three components, large molecular weight, beta-lipotropin-, and beta-EP-sized form; each of these components was incompletely suppressed by somatostatin infusion. It is suggested that certain tumors may have acquired aberrant multiple receptors during malignant transformation which may lead to the paradoxical hormone response as demonstrated in this case.
Nakashima
H
H
Hirata
Y
Y
Uchihashi
M
M
Fujita
T
T
Taniguchi
H
H
Baba
S
S
Matsukura
S
S
D000182:ACTH Syndrome, Ectopic / Q000097:blood*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003533:Cyproheptadine / Q000494:pharmacology*; D004723:Endorphins / Q000097:blood; D006801:Humans; D008236:Lypressin / Q000494:pharmacology; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009384:Paraneoplastic Endocrine Syndromes / Q000097:blood*; D013004:Somatostatin / Q000494:pharmacology*; D013945:Thymoma / Q000097:blood; D013953:Thymus Neoplasms / Q000097:blood; D001615:beta-Endorphin
D004723:Endorphins; D003533:Cyproheptadine; D009270:Naloxone; D008236:Lypressin; D013004:Somatostatin; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone