Cholecystokinin neuron systems and their interactions with the presynaptic features of the dopamine neuron systems. A morphometric and neurochemical analysis involving studies on the action of cholecystokinin-8 and cholecystokinin-58.
A unique role for CCK-58 compared to that for CCK-8 has been demonstrated in the modulation of central catecholaminergic mechanisms and neuroendocrine functions. It is of paramount importance to localize CCK-58 immunoreactivity within the brain in order to establish if separate CCK-58- and CCK-8-immunoreactive neuron systems exist. The two most significant actions of CCK-58 are a marked lowering of TSH secretion and a selective increase of DA turnover in DA-CCK co-existing synapses in the nucleus accumbens and tuberculum olfactorium.
Fuxe
K
K
Agnati
L F
LF
Vanderhaeghen
J J
JJ
Tatemoto
K
K
Andersson
K
K
Eneroth
P
P
Härfstrand
A
A
Von Euler
G
G
Toni
R
R
Goldstein
M
M
D000818:Animals; D001923:Brain Chemistry; D002395:Catecholamines / Q000032:analysis; D002766:Cholecystokinin / Q000032:analysis / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects; D007263:Infusions, Parenteral; D007276:Injections, Intraventricular; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000032:analysis / Q000187:drug effects*; D012844:Sincalide / Q000494:pharmacology*; D013687:Telencephalon / Q000187:drug effects; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D002395:Catecholamines; D011954:Receptors, Dopamine; C038823:cholecystokinin 58; D002766:Cholecystokinin; D014446:Tyrosine 3-Monooxygenase; D012844:Sincalide; D004298:Dopamine