title: Antipsychotic drug side effects: their relationship to dose.
abstract: The risk of adverse side effects of neuroleptic agents must be considered carefully in the treatment of acute and long-term psychotic states. Consequences should be assessed by analysis of dose-response relationships, risk factors, and central nervous system (especially extrapyramidal) side effects, as well as the influence of neuroleptics on neurotransmitter systems. Appropriate minimum dosages of neuroleptics must be further evaluated as an effective measure in reducing these side effects.
authors.forename: J M
authors.initials: JM
authors.lastname: Kane
mesh_terms: D000380:Agranulocytosis / Q000139:chemically induced; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000139:chemically induced / Q000517:prevention & control; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005476:Fluphenazine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D006801:Humans; D007024:Hypotension, Orthostatic / Q000139:chemically induced; D008297:Male; D010787:Photosensitivity Disorders / Q000139:chemically induced; D010859:Pigmentation Disorders / Q000139:chemically induced; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000523:psychology; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012306:Risk; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced
chemical_list: D014150:Antipsychotic Agents; D017981:Receptors, Neurotransmitter; C011825:fluphenazine depot; D005476:Fluphenazine