Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord.
When administered microelectrophoretically, a sulphonic acid derivative of baclofen, 3-amino-2-(4-chlorophenyl)-2-hydroxy-propylsulphonic acid, reversibly reduced the presynaptic reduction by (-)-baclofen of the monosynaptic excitation of spinal interneurones by impulses in low threshold primary afferent fibres of the cat as well as the postsynaptic depression by (-)-baclofen of the firing of these neurones. This compound, 2-hydroxy-saclofen, may be useful in assessing the physiological significance of central baclofen receptors.
Curtis
D R
DR
Neuropharmacology Research Group, John Curtin School of Medical Research, Canberra, A.C.T., Australia.
Gynther
B D
BD
Beattie
D T
DT
Kerr
D I
DI
Prager
R H
RH
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001418:Baclofen / Q000031:analogs & derivatives* / Q000494:pharmacology; D002415:Cats; D004558:Electric Stimulation; D007395:Interneurons / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*
D011963:Receptors, GABA-A; D001418:Baclofen; C057491:2-hydroxysaclofen