[Low molecular weight and protein dinitrosyl complexes of non-heme iron as inhibitors of platelet aggregation].
Dinitrosyl complexes of ferrum with thiosulfate or reduced glutathione were found to inhibit completely aggregation of human thrombocytes, suspended in artificial protein-free medium. The inhibitory effect appears to occur as a result of activating action of nitrogen oxide derived from the complexes and affecting the thrombocyte guanylate cyclase.
Kuznetsov
V A
VA
Mordvintsev
P I
PI
Dank
E Kh
EKh
Iurkiv
V A
VA
Vanin
A F
AF
D001792:Blood Platelets / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D000001:Calcimycin / Q000494:pharmacology; D006152:Cyclic GMP / Q000097:blood; D005978:Glutathione / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007501:Iron / Q000378:metabolism / Q000494:pharmacology*; D008024:Ligands; D010974:Platelet Aggregation / Q000187:drug effects*; D013885:Thiosulfates / Q000378:metabolism / Q000494:pharmacology*; D013917:Thrombin / Q000494:pharmacology
D001798:Blood Proteins; D008024:Ligands; D013885:Thiosulfates; D000001:Calcimycin; D007501:Iron; D013917:Thrombin; D005978:Glutathione; D006152:Cyclic GMP
Nizkomolekuliarnye i belkovye dinitrozil'nye kompleksy negemovogo zheleza kak ingibitory agregatsii trombotsitov.