Exercise-induced fall in coupling of human beta 2-adrenergic receptors.
The purpose of this study was to quantitatively examine to what extent acute exertion diminishes the activity of beta-adrenergic receptors through diminishing coupling. Normal neutrophil membrane preparations containing beta 2-adrenergic receptors were obtained from healthy human volunteers, then exposed to autologous venous plasma obtained before and after acute forearm exertion. There was an acute, dramatic diminution in coupling (P less than .003) after only a few minutes of exercise. Preexertion plasma had no significant effect upon coupling. Substantial diminution in beta-adrenergic receptor sensitivity is thus acutely demonstrable in this model which serves as a model for both metabolic acidosis and acute exertion.
Davies
A O
AO
Department of Medicine, Baylor College of Medicine, Houston, TX 77030.
D000138:Acidosis / Q000097:blood; D000293:Adolescent; D000328:Adult; D002462:Cell Membrane / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D015444:Exercise; D005260:Female; D006801:Humans; D020120:Iodocyanopindolol; D007545:Isoproterenol / Q000378:metabolism; D008297:Male; D009504:Neutrophils / Q000378:metabolism; D005082:Physical Exertion; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism* / Q000502:physiology
D011943:Receptors, Adrenergic, beta; D020120:Iodocyanopindolol; D010869:Pindolol; D000242:Cyclic AMP; D007545:Isoproterenol