Brain dopamine D-1 receptors in senile dementia.
Brain dopamine D-1 binding sites were studied by using [3H]flupenthixol in 4 brain regions of 44 senile patients with neuropathologically verified organic dementia and 28 age-matched controls. The D-1 binding sites were decreased in the substantia nigra and nucleus accumbens in patients with Alzheimer's disease, while no change was found in multi-infarct or combined dementia. The striatal D-1 binding sites were unchanged in all groups of patients. Only a few correlations between various clinical and post-mortem variables and the [3H]flupenthixol binding of the dementia patients were found. The findings of this study indicate that there is reduction of brain D-1 binding sites in patients with Alzheimer's disease.
Rinne
J O
JO
Säkö
E
E
Paljärvi
L
L
Mölsä
P K
PK
Rinne
U K
UK
D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001479:Basal Ganglia / Q000032:analysis; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000032:analysis; D003704:Dementia / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D008032:Limbic System / Q000032:analysis; D011954:Receptors, Dopamine / Q000032:analysis*; D017447:Receptors, Dopamine D1
D014150:Antipsychotic Agents; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1