Newcastle disease virus-infected splenocytes express the proopiomelanocortin gene.
Infection of murine splenocytes with Newcastle disease virus results in expression of the proopiomelanocortin gene as determined by dot and northern blot analysis of total cellular and poly(A)+ cytoplasmic RNA. These data provide the first evidence that the precursor protein for adrenocorticotropin and beta-endorphin can be synthesized by lymphoid cells.
Westly
H J
HJ
Kleiss
A J
AJ
Kelley
K W
KW
Wong
P K
PK
Yuen
P H
PH
D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis / Q000378:metabolism; D000818:Animals; D004723:Endorphins / Q000096:biosynthesis; D005786:Gene Expression Regulation; D008214:Lymphocytes / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009522:Newcastle disease virus / Q000502:physiology*; D011061:Poly A / Q000032:analysis; D011333:Pro-Opiomelanocortin / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D013154:Spleen / Q000166:cytology / Q000378:metabolism; D001615:beta-Endorphin
D004723:Endorphins; D012333:RNA, Messenger; D011061:Poly A; D001615:beta-Endorphin; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone