Effect of phenobarbitone on the pharmacokinetics and tissue levels of amiodarone in the rat.
Phenobarbitone pretreatment has been shown to increase amiodarone total clearance and decrease amiodarone elimination half-life after a single intravenous amiodarone dose in the rat. Coadministration of phenobarbitone with amiodarone for 7 days resulted in decreased tissue amiodarone levels compared to controls. These results may have implications for patients undergoing therapy with amiodarone and concomitant potent enzyme inducing drugs.
Fruncillo
R J
RJ
Bernhard
R
R
Swanson
B N
BN
Vlasses
P H
PH
Ferguson
R K
RK
D000638:Amiodarone / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001572:Benzofurans / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D001572:Benzofurans; C036116:desethylamiodarone; D000638:Amiodarone; D010634:Phenobarbital