title: Experience with the use of depo-medroxyprogesterone acetate in a Nigerian population.
abstract: Eight hundred and ten patients who accepted to use depo-medroxyprogesterone acetate (DMPA) for contraception were studied over a period of 11 years (1976-1986). Important side-effects observed were amenorrhoea (36.3%), weight gain (15.8%), weight loss (10.6%), metrorrhagia (6.7%) and menorrhagia (6.0%). Amenorrhoea, menorrhagia and metrorrhagia were major reasons for discontinuation of DMPA in 11% of acceptors. There were no cases of pregnancy, genital or breast malignancies during DMPA use. Our experience indicates that DMPA as a contraceptive is effective and should be available for suitable clients who demonstrate oestrogen intolerance.
authors.affiliation: Department of Obstetrics & Gynaecology, University College Hospital, Ibadan, Nigeria.
authors.forename: E A
authors.initials: EA
authors.lastname: Falase
authors.forename: E O
authors.initials: EO
authors.lastname: Otolorin
authors.forename: O A
authors.initials: OA
authors.lastname: Ladipo
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000139:chemically induced; D000814:Aniline Compounds / Q000008:administration & dosage / Q000009:adverse effects; D001835:Body Weight / Q000187:drug effects; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007273:Injections, Intramuscular; D009549:Nigeria; D014592:Uterine Hemorrhage / Q000139:chemically induced
chemical_list: D000814:Aniline Compounds; D003271:Contraceptive Agents, Female; C050795:N,N-dimethyl-4-anisidine