Treatment with beta-adrenoceptor blockers reduces plasma melatonin concentration.
In treated hypertensive patients plasma melatonin levels were lower in subjects receiving beta-adrenoceptor blockers than those treated with diuretics. Melatonin concentrations in middle-aged and young control subjects were similar to each other and to those of the diuretic-treated patients. The results suggest that treatment with beta-adrenoceptor blockers causes a persistent reduction in plasma melatonin but it is unclear if this finding has clinical implications.
Cowen
P J
PJ
Bevan
J S
JS
Gosden
B
B
Elliott
S A
SA
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000367:Age Factors; D000368:Aged; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008550:Melatonin / Q000097:blood*; D008875:Middle Aged
D000319:Adrenergic beta-Antagonists; D004232:Diuretics; D008550:Melatonin