The role of adenosine in cerebral vascular regulation during reductions in perfusion pressure.
The adenosine antagonist caffeine was used to test the hypothesis that endogenous adenosine contributes to the regulation of cerebral blood flow during acute reductions in mean arterial blood pressure. Caffeine, administered intraperitoneally in 20 and 40 mg kg-1 doses, failed to alter the autoregulatory flow responses to marked reductions in arterial blood pressure, showing that adenosine is not essential for cerebrovascular regulation during severe hypotension.
Phillis
J W
JW
DeLong
R E
RE
D000241:Adenosine / Q000502:physiology*; D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure; D002110:Caffeine / Q000494:pharmacology; D002560:Cerebrovascular Circulation; D007274:Injections, Intraperitoneal; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D014655:Vascular Resistance / Q000187:drug effects
D002110:Caffeine; D000241:Adenosine