Delta 1-pyrroline-5-carboxylate dehydrogenase, a possible regulatory enzyme in transmitter glutamic acid metabolism--a preliminary report.
At 10 mM (unless stated), GABA (5 mM), glycine and hydroxyproline inhibited delta 1-pyrroline-5-carboxylate dehydrogenase by 84, 85 and 76%, respectively. Glutamate, glutamine, proline, cysteine and alanine inhibited delta 1-pyrroline-5-carboxylate dehydrogenase by 41-59%. Other amino acids studied were either ineffective or marginally effective. It is concluded that delta 1-pyrroline-5-carboxylate dehydrogenase may be a regulatory enzyme in the ornithine-glutamate pathway.
Wong
P T
PT
Leong
S F
SF
D050842:1-Pyrroline-5-Carboxylate Dehydrogenase; D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D002531:Cerebellum / Q000201:enzymology; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006863:Hydrogen-Ion Concentration; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D005971:Glutamates; D018377:Neurotransmitter Agents; D018698:Glutamic Acid; D050842:1-Pyrroline-5-Carboxylate Dehydrogenase; D000587:Oxidoreductases Acting on CH-NH Group Donors