title: Effect of somatostatin on growth hormone and prolactin response to dermorphin in man.
abstract: The effects of iv somatostatin (somatotrophin release inhibiting factor (SRIF) on growth hormone (GH) and prolactin (Prl) response to dermorphin (D) were tested in 6 healthy men. In all subjects D induced a significant increase in GH and Prl levels, as expected. SRIF completely blocked the GH-releasing activity of D, whereas it only reduced the Prl-releasing activity. The results confirm that D is a potent stimulant for GH and Prl release in man, and furthermore demonstrate that the action of D on GH secretion can be completely overridden by SRIF.
authors.forename: E C
authors.initials: EC
authors.lastname: degli Uberti
authors.forename: G
authors.initials: G
authors.lastname: Trasforini
authors.forename: S
authors.initials: S
authors.lastname: Salvadori
authors.forename: A
authors.initials: A
authors.lastname: Margutti
authors.forename: V
authors.initials: V
authors.lastname: Teodori
authors.forename: C
authors.initials: C
authors.lastname: Rotola
authors.forename: R
authors.initials: R
authors.lastname: Tomatis
authors.forename: R
authors.initials: R
authors.lastname: Pansini
mesh_terms: D000328:Adult; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D011388:Prolactin / Q000378:metabolism*; D013004:Somatostatin / Q000494:pharmacology*
chemical_list: D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin; D013004:Somatostatin; D011388:Prolactin; D013006:Growth Hormone