Effects of postnatal protein undernutrition on myelination in rat brain.
Pups were subjected, from birth, to protein undernutrition by feeding the lactating dams 8% casein (CS) or 8% soy protein (SP) diet up to weaning; the weanlings were fed the same diets until 6 weeks of age. At 3 and 6 weeks of age, myelin was isolated from the brains and characterized. The quantities of myelin and its content of cholesterol, galactolipids and phospholipids, were significantly depressed in the 8% CS and 8% SP groups but not when soy protein was fed at the same level as casein (25%) in the control. Furthermore, the severity of the deficits in myelination showed a differential pattern depending on the type of dietary protein fed. At weaning, the deficits with the 8% SP diet were 1.5-2.0-times greater than with the corresponding casein diet. A more pronounced retardation in the initiation, progression and capacity of myelination in postnatal soy protein undernutrition was indicated.
Egwim
P O
PO
Cho
B H
BH
Kummerow
F A
FA
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000254:growth & development / Q000503:physiopathology*; D002364:Caseins / Q000172:deficiency*; D009186:Myelin Sheath / Q000502:physiology*; D011488:Protein Deficiency / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013025:Glycine max
D002364:Caseins