[Pharmacokinetics of fenazepam and its metabolite 3-oxyfenazepam in animals of different species and in man].
It has been established that phenazepam is rapidly absorbed from the gastrointestinal tract of animals and man. The maximal concentrations of the unchanged drugs are reached 1, 0.5, 2 and 4 hours in rats, dogs, cats and man, respectively. The half-life of phenazepam in animal and human blood decreases in the following order: man greater than cat greater than dog greater than rat. The metabolite 3 + hydroxyphenazepam was identified in appreciable amounts in cat and rat blood.
Zherdev
V P
VP
Martynova
L A
LA
Caccia
S
S
Garattini
S
S
Ekonomov
A L
AL
D000818:Animals; D014151:Anti-Anxiety Agents / Q000097:blood* / Q000627:therapeutic use; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000097:blood* / Q000627:therapeutic use; D002415:Cats; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D008297:Male; D009440:Neurasthenia / Q000097:blood / Q000188:drug therapy; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; C038294:3-hydroxyphenazepam
Farmakokinetika fenazepama i ego metabolita 3-oksifenazepama u zhivotnykh raznykh vidov i cheloveka.