title: Effect of phenobarbitone on the pharmacokinetics and tissue levels of amiodarone in the rat.
abstract: Phenobarbitone pretreatment has been shown to increase amiodarone total clearance and decrease amiodarone elimination half-life after a single intravenous amiodarone dose in the rat. Coadministration of phenobarbitone with amiodarone for 7 days resulted in decreased tissue amiodarone levels compared to controls. These results may have implications for patients undergoing therapy with amiodarone and concomitant potent enzyme inducing drugs.
authors.forename: R J
authors.initials: RJ
authors.lastname: Fruncillo
authors.forename: R
authors.initials: R
authors.lastname: Bernhard
authors.forename: B N
authors.initials: BN
authors.lastname: Swanson
authors.forename: P H
authors.initials: PH
authors.lastname: Vlasses
authors.forename: R K
authors.initials: RK
authors.lastname: Ferguson
mesh_terms: D000638:Amiodarone / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001572:Benzofurans / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001572:Benzofurans; C036116:desethylamiodarone; D000638:Amiodarone; D010634:Phenobarbital