Molecular size of the high-affinity glutamate-binding site on synaptic membranes from rat brain.
We have used radiation inactivation as a means of determining the molecular size of the high-affinity glutamate-binding site on rat brain synaptic membranes. The molecular size was 75,000 +/- 15,000 in the absence of glutamate and 263,000 +/- 34,000 in the presence of glutamate. These data may be interpreted as suggesting that the high-affinity glutamate-binding site is comprised of a number of subunits. The minimum sub-unit size detected by this method was 75,000 +/- 15,000.
Bardsley
M E
ME
Roberts
P J
PJ
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D046911:Macromolecular Substances; D008297:Male; D008433:Mathematics; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains; D013570:Synaptic Membranes / Q000378:metabolism*
D005971:Glutamates; D046911:Macromolecular Substances; D018698:Glutamic Acid