Fluperlapine vs haloperidol: a comparison of their neuroendocrinological profiles and the influence on serum lipids.
Twelve male patients suffering from acute paranoid schizophrenia, randomly receiving fluperlapine - a new dibenzodiazepine very similar to clozapine - or haloperidol were included in a double blind study. Plasma levels of triglyceride, cholesterol and HDL-cholesterol, prolactin, thyroxine, triiodothyronine, ACTH and cortisol were determined. There was no evidence, that fluperlapine has any relevant influence on those hypothalamic-pituitary axis mediated hormones with the possible exception of plasma lipids. These findings, together with the clinical experiences, suggest that fluperlapine might have a different mode of action than conventional neuroleptics.
Fleischhacker
W W
WW
Stuppäck
C
C
Moser
C
C
Schubert
H
H
Hinterhuber
H
H
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003984:Dibenzazepines / Q000627:therapeutic use*; D006220:Haloperidol / Q000627:therapeutic use*; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D011388:Prolactin / Q000097:blood; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D013963:Thyroid Hormones / Q000097:blood
D014150:Antipsychotic Agents; D003984:Dibenzazepines; D006728:Hormones; D008055:Lipids; D013963:Thyroid Hormones; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; C041528:fluperlapine; D006220:Haloperidol; D006854:Hydrocortisone