Enhancement of nasal absorption of insulin and calcitonin using polyacrylic acid gel.
The effects of polyacrylic acid gel on the nasal absorption of insulin and [Asu1,7]-eel calcitonin were investigated in rats. The nasal administration of insulin (1 IU kg-1) in polyacrylic acid gel at 0.1 and 1% w/v showed maximum hypoglycaemic effects at 30 min and 1 h after administration, respectively. However, the nasal administration of insulin in carboxymethyl cellulose (1% w/v) solution had no hypoglycaemic effect at the same dose. When [Asu1,7]-eel calcitonin (10 U kg-1) was administered nasally in polyacrylic acid gel (0.1% w/v), a prominent hypocalcaemic effect was observed during the first 30 min. Nasal administration of [Asu1,7]-eel calcitonin in saline had no hypocalcaemic effect at the same dose. The results indicate that the polyacrylic acid gel base significantly enhanced the absorption of insulin and [Asu1,7]-eel calcitonin via the nasal cavity.
Morimoto
K
K
Morisaka
K
K
Kamada
A
A
D000042:Absorption; D000180:Acrylic Resins / Q000494:pharmacology*; D000818:Animals; D002116:Calcitonin / Q000378:metabolism*; D005782:Gels; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000378:metabolism*; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000180:Acrylic Resins; D005782:Gels; D007328:Insulin; C006903:carbopol 940; D002116:Calcitonin