title: [Pharmacokinetics of fenazepam and its metabolite 3-oxyfenazepam in animals of different species and in man].
abstract: It has been established that phenazepam is rapidly absorbed from the gastrointestinal tract of animals and man. The maximal concentrations of the unchanged drugs are reached 1, 0.5, 2 and 4 hours in rats, dogs, cats and man, respectively. The half-life of phenazepam in animal and human blood decreases in the following order: man greater than cat greater than dog greater than rat. The metabolite 3 + hydroxyphenazepam was identified in appreciable amounts in cat and rat blood.
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: L A
authors.initials: LA
authors.lastname: Martynova
authors.forename: S
authors.initials: S
authors.lastname: Caccia
authors.forename: S
authors.initials: S
authors.lastname: Garattini
authors.forename: A L
authors.initials: AL
authors.lastname: Ekonomov
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000097:blood* / Q000627:therapeutic use; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000097:blood* / Q000627:therapeutic use; D002415:Cats; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D008297:Male; D009440:Neurasthenia / Q000097:blood / Q000188:drug therapy; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; C038294:3-hydroxyphenazepam
vernacular_title: Farmakokinetika fenazepama i ego metabolita 3-oksifenazepama u zhivotnykh raznykh vidov i cheloveka.