title: [Interaction of prostaglandin E2 with receptors and their effect on adenylate cyclase activity in human thyroid tissue].
abstract: The investigations have been performed on thyroid tissue excised from patients suffering from euthyroid goiter and thyrotoxicosis. The study of thyroid thyrotoxic tissue has revealed the decrease in the number of free receptors to 3H-PGE2 caused by the enhanced production of receptor-endogenous PGE2 complexes whose level in thyrotoxic tissue was significantly higher than in euthyroid tissue. PGE2 and GppNHp had a pronounced stimulating effect on adenylate cyclaze activity both in euthyroid and thyrotoxic tissues, with enzyme sensitivity to stimulating effects considerably increased in the latter case.
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Gal'chinskaia
authors.forename: E S
authors.initials: ES
authors.lastname: Rom-Bugoslavskaia
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Lille
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D015232:Dinoprostone; D004347:Drug Interactions; D006044:Goiter, Nodular / Q000201:enzymology; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology; D006801:Humans; D006980:Hyperthyroidism / Q000201:enzymology; D066298:In Vitro Techniques; D007700:Kinetics; D008024:Ligands; D011458:Prostaglandins E / Q000378:metabolism / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011982:Receptors, Prostaglandin / Q000187:drug effects* / Q000378:metabolism; D018078:Receptors, Prostaglandin E; D013268:Stimulation, Chemical; D013961:Thyroid Gland / Q000187:drug effects* / Q000201:enzymology
chemical_list: D008024:Ligands; D011458:Prostaglandins E; D011956:Receptors, Cell Surface; D011982:Receptors, Prostaglandin; D018078:Receptors, Prostaglandin E; D006165:Guanylyl Imidodiphosphate; D000262:Adenylyl Cyclases; D015232:Dinoprostone
vernacular_title: Vzaimodeĭstvie prostaglandinov E2 s retseptorami i ikh vliianie na aktivnost' adenilattsiklazy v tkani shchitovidnoĭ zhelezy cheloveka.