Hodgkin-cell leukaemia of B-cell origin.
A case of lymphocyte-depleted nodular sclerosing Hodgkin's disease with a terminal leukaemic phase is described. Circulating Hodgkin cells were shown to be of B-cell origin by immunological phenotyping and the demonstration of clonal immunoglobulin gene rearrangement.
Linch
D C
DC
Jones
H M
HM
Berliner
N
N
MacLennan
K
K
O'Flynn
K
K
Huehns
E R
ER
Kay
L A
LA
Goff
K
K
D000368:Aged; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000145:classification / Q000276:immunology* / Q000378:metabolism / Q000648:ultrastructure; D002118:Calcium / Q000378:metabolism; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007938:Leukemia / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D010641:Phenotype; D010835:Phytohemagglutinins / Q000494:pharmacology
D000911:Antibodies, Monoclonal; D007136:Immunoglobulins; D010835:Phytohemagglutinins; D002118:Calcium