Skin conductance reaction (SCR)-habituation test, a tool to detect anxiolytic activity. Its justification by the correlation between SCR-habituation test activities and specific binding potencies in benzodiazepines.
Correlation between specific binding potencies "in vitro" of several benzodiazepines and activities in SCR-habituation test is very satisfactory. As the SCR-habituation test might be considered as an elementary model of anxiety state, the test is suggested to be used as an intermediate psychopharmacological tool before clinical study. SCR-magnitude test exhibits no correlation of this kind proving that sedative activity is of a different mechanism.
Marcy
R
R
Quermonne
M A
MA
Raoul
J
J
Nammathao
B
B
Smida
A
A
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy*; D001569:Benzodiazepines; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005712:Galvanic Skin Response / Q000187:drug effects*; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D051379:Mice
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines