title: Pharmacology of the erectile tissue of the canine penis.
abstract: To assess the role of different neuroeffector systems in penile erection, pharmacological agents were tested in vitro using strips of corpus cavernosum tissue from the dog. Alpha-adrenoceptor agonists, K+ or histamine caused concentration-dependent contraction. Tyramine caused a poorly sustained contraction, as did nicotine in some cases. In precontracted preparations, relaxation was caused by beta2-adrenoceptor or muscarinic cholinoceptor agonists, or by vasoactive intestinal peptide. The results suggest that a noradrenergic alpha-adrenoceptor system maintains penile flaccidity in the dog. Penile erection may result from the activation of inhibitory beta2-adrenergic, muscarinic and/or peptidergic systems.
authors.forename: C J
authors.initials: CJ
authors.lastname: Carati
authors.forename: R G
authors.initials: RG
authors.lastname: Goldie
authors.forename: A
authors.initials: A
authors.lastname: Warton
authors.forename: P J
authors.initials: PJ
authors.lastname: Henry
authors.forename: E J
authors.initials: EJ
authors.lastname: Keogh
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D004285:Dogs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology; D010410:Penile Erection / Q000187:drug effects*; D010656:Phenylephrine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
chemical_list: D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D008688:Methacholine Compounds; D010276:Parasympatholytics; D010656:Phenylephrine; D014660:Vasoactive Intestinal Peptide; D006632:Histamine; D002217:Carbachol; D011188:Potassium