title: [Treatment of malignant intracranial germ-cell tumors in children. 7 cases].
abstract: Seven children, aged from 9 to 16 years, with intracranial germ cell tumour received post-operative chemotherapy prior to radiotherapy. Treatment consisted of several courses of vinblastine, bleomycin and cisplatin alternating or not with courses of cyclophosphamide and actinomycin D. In the 6 children whose tumours secreted alphafoetoprotein or chorionic gonadotrophin, chemotherapy brought these markers down to normal. Tumoral regression at radiology exceeded 75 per cent in 6 patients. These results demonstrate the effectiveness of chemotherapy against intracranial germ cell tumours such as pure germinomas or secreting tumours. They encourage the systematic use of pre-irradiation chemotherapy in order to reduce the radiation doses delivered and to improve the prognosis.
authors.affiliation: Service de Pédiatrie B, Hôtel-Dieu, CHRU, BP 69, Clermont-Ferrand.
authors.forename: F
authors.initials: F
authors.lastname: Deméocq
authors.forename: M C
authors.initials: MC
authors.lastname: Baranzelli
authors.forename: D
authors.initials: D
authors.lastname: Rénier
authors.forename: C
authors.initials: C
authors.lastname: Dionet
authors.forename: L
authors.initials: L
authors.lastname: de Lumley
authors.forename: E
authors.initials: E
authors.lastname: Legall
authors.forename: F
authors.initials: F
authors.lastname: Flamant
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy; D004407:Dysgerminoma / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D009373:Neoplasms, Germ Cell and Embryonal / Q000628:therapy*; D013125:Spinal Neoplasms / Q000556:secondary; D013997:Time Factors
vernacular_title: Traitement des tumeurs germinales malignes intracrâniennes de l'enfant. Sept cas.