Biochemical mechanisms responsible for alcohol-associated myocardiopathy.
An overview of alcohol metabolism is presented followed by a discussion of the unique pathways for the metabolism of ethanol by the heart. The evidence for cardiac metabolic injury produced as a result of ethanol metabolism is then presented. Such injury involves the mitochondria, contractile proteins, and alterations in calcium fluxes and storage.
Van Thiel
D H
DH
Gavaler
J S
JS
Lehotay
D C
DC
D000079:Acetaldehyde / Q000633:toxicity; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002310:Cardiomyopathy, Alcoholic / Q000209:etiology* / Q000378:metabolism; D003285:Contractile Proteins / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D010750:Phosphoproteins / Q000032:analysis; D010766:Phosphorylation
D003285:Contractile Proteins; D005227:Fatty Acids; D010750:Phosphoproteins; D000431:Ethanol; D006162:Guanylate Cyclase; D000079:Acetaldehyde; D002118:Calcium