GABAB receptor activation inhibits 5-hydroxytryptamine-stimulated inositol phospholipid turnover in mouse cerebral cortex.
The effects of GABA agonists on inositol phospholipid metabolism were investigated in mouse cerebral cortex. GABA (in the presence of 1 mM nipecotic acid) dose dependently inhibited 5-hydroxytryptamine (5-HT)-stimulated [3H]inositol phosphate formation; maximal inhibition 60.4 +/- 8.8%, ED50 200 nM. The GABAB agonist baclofen had a similar effect; maximal inhibition 41.7 +/- 4.5%, ED50 100 nM. The inhibitory action of GABA was not blocked by bicucculine. The results suggest that GABAB receptors may modulate 5-HT2 receptor function at the level of signal transduction.
Godfrey
P P
PP
University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, U.K.
Grahame-Smith
D G
DG
Gray
J A
JA
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D007294:Inositol / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010743:Phospholipids / Q000378:metabolism*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology*
D010743:Phospholipids; D011963:Receptors, GABA-A; D012701:Serotonin; D007294:Inositol