[Entry of cyclic nucleotides into frog muscles in vivo and in vitro].
The radioactive isotopes of cyclic nucleotides were used to study the possibility of their income to the isolated frog muscle from the environment as well as their distribution between blood plasma and muscle after injection to an animal. It is shown that the intracellular levels of nucleotides may be considerably higher after soaking the isolated muscle in 10(-6) M cGMP or 10(-4) cAMP solutions. After the cAMP injection into the lymphatic sac its content in blood and especially in muscles is high for a long time. In this case the label loss in muscles proceeds slower than in blood. A conclusion is drawn that conduction of studies on the artificial increase of the intracellular level of cyclic nucleotides by means of their injection to an animal is appropriate.
Kudriavtseva
N V
NV
Nasledov
G A
GA
Nikol'skiĭ
N N
NN
Volkov
E M
EM
D000818:Animals; D002854:Chromatography, Paper; D000242:Cyclic AMP / Q000097:blood / Q000378:metabolism*; D006152:Cyclic GMP / Q000097:blood / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D009132:Muscles / Q000378:metabolism*; D011896:Rana temporaria
D000242:Cyclic AMP; D006152:Cyclic GMP
Postuplenie tsiklicheskikh nukleotidov v myshtsy liagushki v usloviiakh in vivo i in vitro.