Studies of contents of norepinephrine and 5-hydroxytryptamine in brain--II. Effect of sodium barbitone and chlorpromazine.
The effect of i.p. injection of sodium barbitone and chlorpromazine (25 mg/100 g body wt) on the levels of NE, 5-HT and body temperature was investigated in the brain regions of the field rat and the guinea-pig. Injection of the field rat with barbitone sodium or chlorpromazine provoked a general increase in the NE and 5-HT concentrations of the various brain parts. In guinea-pig variable changes were observed. Following injection with either of the two drugs, hypothermia was induced in the two animals at all of the time intervals examined.
Rahman
T A
TA
Mohamed
M I
MI
Aly
M S
MS
Moustafa
S
S
D000818:Animals; D001462:Barbital / Q000494:pharmacology*; D001463:Barbiturates / Q000494:pharmacology*; D001833:Body Temperature Regulation / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping; D002746:Chlorpromazine / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009115:Muridae; D009638:Norepinephrine / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*
D001463:Barbiturates; D012701:Serotonin; D001462:Barbital; D002746:Chlorpromazine; D009638:Norepinephrine