title: Pharmacokinetic parameters of bevantolol in volunteers.
abstract: The pharmacokinetics of the new beta-adrenoceptor blocking drug bevantolol and some aspects of its beta-blocking effect have been studied in healthy volunteers. Bevantolol had a short serum half-life (86 +/- 33 min) and high systemic availability after oral administration. The observed changes in heart rate, systolic blood pressure during exercise and plasma renin activity were all compatible with beta-adrenoceptor blockade. After 200 mg p.o. in the morning, the effects lasted for less than 24 h.
authors.forename: P
authors.initials: P
authors.lastname: Vermeij
authors.forename: P
authors.initials: P
authors.lastname: van Brummelen
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000378:metabolism* / Q000494:pharmacology; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008297:Male; D011412:Propanolamines / Q000378:metabolism* / Q000494:pharmacology; D012083:Renin / Q000097:blood; D013997:Time Factors
chemical_list: D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C021148:bevantolol; D012083:Renin