Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor.
Kynurenate produces an unsurmountable antagonism of the response to N-methyl-D-aspartate (NMDA) in the baby rat hemisected spinal cord. This effect is completely reversible and prevented by co-superfusion with D-serine or glycine in the presence of strychnine. In the presence of D-serine kynurenate acts as a weak competitive antagonist. The results suggest that one of the actions of kynurenate is to antagonise NMDA responses via an action at the strychnine-insensitive glycine receptor.
Birch
P J
PJ
Department of Neuropharmacology, Glaxo Group Research, Ware, Herts., U.K.
Grossman
C J
CJ
Hayes
A G
AG
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D005998:Glycine / Q000494:pharmacology; D066298:In Vitro Techniques; D007736:Kynurenic Acid / Q000494:pharmacology*; D016202:N-Methylaspartate; D051381:Rats; D011919:Rats, Inbred Strains; D018009:Receptors, Glycine; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D012694:Serine / Q000494:pharmacology; D013331:Strychnine / Q000494:pharmacology*
D018009:Receptors, Glycine; D017981:Receptors, Neurotransmitter; D001224:Aspartic Acid; D012694:Serine; D016202:N-Methylaspartate; D007736:Kynurenic Acid; D013331:Strychnine; D005998:Glycine