title: Visualization of growth factor receptor sites in rat forebrain.
abstract: It is now known that various growth factors may also act in the central nervous system. Among them, it has recently been shown that epidermal growth factor (EGF) and insulin-like growth factor I (IGF-I) may possess trophic effects in the mammalian brain. We report here on the respective autoradiographic distribution of [125I]EGF and [125I]IGF-I receptor binding sites in the rat brain, both during ontogeny and in adulthood. It appears that [125I]EGF sites are mostly found in the rat forebrain during brain development. On the other hand, [125I]IGF-I sites are more widely distributed both during ontogeny and in adulthood. These results reveal the plasticity of the expression of EGF and IGF-I receptor sites in the mammalian brain. This could be relevant for the respective role of these two growth factors in the development and maintenance of neuronal function.
authors.affiliation: Douglas Hospital Research Centre, McGill University, Verdun, Québec, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Quirion
authors.forename: D
authors.initials: D
authors.lastname: Araujo
authors.forename: N P
authors.initials: NP
authors.lastname: Nair
authors.forename: J G
authors.initials: JG
authors.lastname: Chabot
mesh_terms: D000375:Aging; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007457:Iodine Radioisotopes; D009928:Organ Specificity; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017451:Receptors, Somatomedin; D013002:Somatomedins / Q000378:metabolism*
chemical_list: D007457:Iodine Radioisotopes; D011956:Receptors, Cell Surface; D017451:Receptors, Somatomedin; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D066246:ErbB Receptors