Atrial natriuretic peptide in the central nervous system of the rat.
1. Studies of the presence of atrial natriuretic peptide immunoreactivity and receptor binding sites in the central nervous system have revealed unusual sites of interest. 2. As a result, numerous studies have appeared that indicate that brain atrial natriuretic peptide is implicated in the regulation of blood pressure, fluid and sodium balance, cerebral blood flow, brain microcirculation, blood-brain barrier function, and cerebrospinal fluid production. 3. Alteration of the atrial natriuretic peptide system in the brain could have important implications in hypertensive disease and disorders of water balance in the central nervous system.
Skofitsch
G
G
Department of Zoology, University of Graz, Austria.
Jacobowitz
D M
DM
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000276:immunology* / Q000378:metabolism* / Q000502:physiology; D001931:Brain Mapping; D002319:Cardiovascular System / Q000187:drug effects; D002490:Central Nervous System / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D017461:Receptors, Atrial Natriuretic Factor; D011956:Receptors, Cell Surface / Q000378:metabolism*
D011956:Receptors, Cell Surface; D009320:Atrial Natriuretic Factor; D017461:Receptors, Atrial Natriuretic Factor