[The affinity of aromatic fluoride derivatives of phenothiazine neuroleptics to spiroperidol binding sites of dopamine receptors by the radioligand technic in vitro].
By introduction of fluorine into the position 7 of butaperazine, chlorpromazine, methoxypromazine, perphenazine, prochlorperazine or into the position 3 of promazine derivatives are obtained with higher affinities for the 3H-spiroperidol binding site of the dopamine receptor compared with the corresponding substances free of fluorine.
Oelssner
W
W
Peinhardt
G
G
Büge
A
A
D000818:Animals; D014150:Antipsychotic Agents / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D002090:Butyrophenones / Q000378:metabolism*; D006220:Haloperidol / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D010640:Phenothiazines; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism*
D014150:Antipsychotic Agents; D002090:Butyrophenones; D010640:Phenothiazines; D011954:Receptors, Dopamine; D013134:Spiperone; D006220:Haloperidol
Untersuchungen zur Affinität kernfluorierter Derivate von Phenothiazin-Neuroleptica zur 3H-Spiroperidol-Bindungsstelle des Dopaminrezeptors mittels Radioligandtechnik in vitro.