Protection of microvasculature in rat brain against late radiation injury by gammaphos.
The ability of the radioprotector gammaphos to modify the development of late vascular changes in rat brain after local irradiation with 25 Gy was investigated by means of angiographic method. A protective effect was seen against late vascular abnormalities. It is suggested that a causative relationship exists between vascular abnormalities, brain necrosis, and radiation mortality after irradiation with moderate doses.
Plotnikova
E D
ED
Institute of Biological Physics, Academy of Sciences of the USSR, Pushchino, Moscow Region.
Levitman
M K
MK
Shaposhnikova
V V
VV
Koshevoj
J V
JV
Eidus
L K
LK
D004999:Amifostine / Q000627:therapeutic use*; D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000528:radiation effects; D008833:Microcirculation / Q000187:drug effects / Q000528:radiation effects*; D009946:Organothiophosphorus Compounds / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D009946:Organothiophosphorus Compounds; D011837:Radiation-Protective Agents; D004999:Amifostine