title: Intraphagocytic penetration of antibiotics.
abstract: The penetration of several antibiotics into human polymorphonuclear leucocytes was measured with a bioassay. The aminoglycosides (gentamicin, netilmicin), oxacillin and LY146032, a new lipopeptidic antibiotic, had a penetration which was generally less than 60%, whereas new fluoro-quinolones (enoxacin, ciprofloxacin, CI934, Ro236240) and rifamycins (rifampicin, LM427) were concentrated 2.4 to 14.2-fold. The concentration of vancomycin and teicoplanin associated with the neutrophils appeared to be saturable over the range of extracellular concentrations tested (5-20 mg/l). Coumermycin, an inhibitor of DNA-gyrase, was highly concentrated (11.3 to 16.6-fold) within the neutrophils. The penetration of clindamycin and erythromycin was low (0.60- to 1.48-fold).
authors.affiliation: Laboratoire d'Investigation Clinique H. J. Tagnon, Service de Médecine, Institut Jules Bordet, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Van der Auwera
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Husson
mesh_terms: D042462:4-Quinolones; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000493:pharmacokinetics; D017576:Daptomycin; D008826:Microbial Sensitivity Tests; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010068:Oxacillin / Q000493:pharmacokinetics; D010455:Peptides / Q000493:pharmacokinetics; D012294:Rifamycins / Q000493:pharmacokinetics
chemical_list: D042462:4-Quinolones; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D010455:Peptides; D012294:Rifamycins; D017576:Daptomycin; D010068:Oxacillin