[Antigenic structure of the foot-and-mouth disease virus. II. Synthesis of protective peptides from the major immunogenic region of VP1 protein of foot-and-mouth disease virus type A22].
Earlier we found that the immune response and antiviral protection from FMDV can be achieved by immunization with uncoupled FMDV peptides. In a search of approaches to animal protection from FMDV A22 strain we prepared a series of peptides corresponding to the putative antigenic determinants. Synthetic 131-149 and 140-149 sequences afforded 50 to 80% protection, both in the free state and conjugated with keyhole limpet hemocyanin. We believe that the 140-149 segment is so far the smallest peptide capable of eliciting specific antiviral protection without conjugation with a high molecular carrier.
Vol'pina
O M
OM
Surovoĭ
A Iu
AIu
Ul'iashin
V V
VV
Ivanov
V T
VT
Chepurkin
A V
AV
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D005537:Aphthovirus / Q000276:immunology*; D002851:Chromatography, High Pressure Liquid; D005536:Foot-and-Mouth Disease / Q000517:prevention & control; D006168:Guinea Pigs; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology*; D014764:Viral Proteins / Q000138:chemical synthesis / Q000276:immunology*; D015678:Viral Structural Proteins; D014765:Viral Vaccines
D000956:Antigens, Viral; D010455:Peptides; D014764:Viral Proteins; D015678:Viral Structural Proteins; D014765:Viral Vaccines
Antigennaia struktura virusa iashchura. II. Sintez protektivnykh peptidov posledovatel'nosti osnovnogo immunogennogo raĭona belka VP1 virusa iashchura shtamma A22.