title: Permeability of the blood-retinal barrier in myopia. An analysis employing vitreous fluorophotometry and computer simulation.
abstract: Vitreous fluorophotometry was performed in 165 eyes of 93 cases with various degrees of myopia. The age range was 10-39 years. On background of the significant correlation between the refractive diopter value and the length of vitreous cavity, a simulation model for myopia has been established for assessing the permeability of the blood-retinal barrier. Significant negative correlations between the diopter and P-in and the diopter and D-p were found, indicating that by increasing degree of myopia, the functional disorder of the blood-retinal barrier and the liquefaction of the posterior vitreous gel progress. From the comparative study between eyes with slight myopia and eyes with emmetropia, a significant increase in the length of the vitreous cavity and P-in was found in the former, whereas no significant difference was observed in D-p. Therefore, it is suggested that the functional disorder of the blood-retinal barrier in myopia produces the liquefaction of the posterior vitreous gel.
authors.affiliation: Department of Ophthalmology, Asahikawa Medical College, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Hosaka
mesh_terms: D000293:Adolescent; D000328:Adult; D001813:Blood-Retinal Barrier; D002199:Capillary Permeability; D002648:Child; D003198:Computer Simulation; D005451:Fluorescein Angiography; D006801:Humans; D009216:Myopia / Q000503:physiopathology*; D012029:Refraction, Ocular; D014822:Vitreous Body / Q000503:physiopathology