title: Solubility of diazepam and prazepam in aqueous non-ionic surfactants.
abstract: The solubility of diazepam and prazepam in aqueous polyoxyethylen-10-dodecanol, polyoxyethylen-23-dodecanol and polyoxyethylen-20-hexadecanol, has been determined at 25.0 degrees C. Diazepam seems to achieve a higher micellar penetration than prazepam, in spite of an expected smaller hydrophobic character. Thermodynamic interpretation of the micellar solutions is carried out using the regular solutions approach. A surfactant-independent relation between solubilities of both drugs has been derived.
authors.forename: M E
authors.initials: ME
authors.lastname: Moro
authors.forename: M M
authors.initials: MM
authors.lastname: Velazquez
authors.forename: J M
authors.initials: JM
authors.lastname: Cachaza
authors.forename: L J
authors.initials: LJ
authors.lastname: Rodriguez
mesh_terms: D003975:Diazepam; D008823:Micelles; D011092:Polyethylene Glycols; D011222:Prazepam; D012995:Solubility; D013816:Thermodynamics
chemical_list: D008823:Micelles; D011092:Polyethylene Glycols; D011222:Prazepam; D003975:Diazepam