The effect of auranofin on the colonic transport of Na+ and fluid in the rat.
Auranofin in the mucosal fluid caused a dose-dependent inhibition of fluid and Na+ absorption by everted sacs of rat colon. Serosal auranofin was without effect. (Na+ + K+)ATPase activity of homogenates of mucosal scrapes of rat colon was inhibited by auranofin in a dose-related manner, while Mg2+-ATPase activity was little affected. These actions of the drug on colonic transport mechanisms could contribute to the diarrhoea associated with auranofin therapy.
Hardcastle
J
J
Hardcastle
P T
PT
Kelleher
D K
DK
Fondacaro
J D
JD
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001310:Auranofin; D006051:Aurothioglucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D003106:Colon / Q000378:metabolism*; D006046:Gold / Q000031:analogs & derivatives*; D007413:Intestinal Mucosa / Q000201:enzymology; D008297:Male; D051381:Rats; D012964:Sodium / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D006051:Aurothioglucose; D001310:Auranofin; D006046:Gold; D012964:Sodium; D000251:Adenosine Triphosphatases