Coxsackie-B-virus-specific IgM responses, complement-fixing islet-cell antibodies, HLA DR antigens, and C-peptide secretion in insulin-dependent diabetes mellitus.
To evaluate the role of Coxsackie B viruses in the pathogenesis of insulin-dependent (juvenile-onset, type 1) diabetes mellitus (IDDM), attempts were made to correlate virus-specific IgM responses with HLA genes, autoimmune responses, and C-peptide secretion. HLA DR3, DR4, or both were present in 73 of 90 (81%) diabetic patients; 22 of 23 (96%) with Coxsackie-B-virus-specific IgM had at least one of these HLA types, compared with 51 of 67 (76%) without virus-specific IgM. There was no correlation between HLA A, B, or C types or immunoglobulin allotypes and virus-specific IgM responses. 16 of 22 (64%) patients with Coxsackie-B-virus-specific IgM compared with 26 of 72 (36%) without had complement-fixing islet-cell antibodies; no relation was found between virus-specific IgM and antibodies against thyroid or adrenal tissue or parietal cells. C-peptide secretion was significantly lower in patients with Coxsackie-B-virus-specific IgM.
Schernthaner
G
G
Banatvala
J E
JE
Scherbaum
W
W
Bryant
J
J
Borkenstein
M
M
Schober
E
E
Mayr
W R
WR
D000293:Adolescent; D000311:Adrenal Glands / Q000276:immunology; D000328:Adult; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis* / Q000096:biosynthesis / Q000276:immunology; D002096:C-Peptide / Q000378:metabolism*; D002648:Child; D003168:Complement Fixation Tests; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000378:metabolism / Q000382:microbiology*; D029822:Enterovirus B, Human / Q000276:immunology*; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis* / Q000276:immunology; D007330:Insulin Antibodies / Q000032:analysis; D010295:Parietal Cells, Gastric / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology
D000914:Antibodies, Viral; D001323:Autoantibodies; D002096:C-Peptide; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D007075:Immunoglobulin M; D007330:Insulin Antibodies; C024211:islet cell antibody