Vecuronium and d-tubocurarine combination: potentiation of effect.
To evaluate possible potentiation of neuromuscular blocking effect of a combination of vecuronium and d-tubocurarine, cumulative dose-response curves were constructed to compare the potency of this combination with vecuronium and d-tubocurarine given alone. Ten patients each were given incremental injections of 80 micrograms/kg d-tubocurarine or 5 micrograms/kg vecuronium plus 40 micrograms/kg d-tubocurarine, the data for incremental administration of 10 micrograms/kg vecuronium being used from our previously published study (7). The results showed the combination of vecuronium plus d-tubocurarine to be significantly more potent (P less than 0.05) than would be expected from a simple additive effect of the individual drugs given alone. The ED95 doses of d-tubocurarine and vecuronium were 530 micrograms/kg and 57 micrograms/kg, respectively, when administered alone, but when administered together, the ED95 doses were 160 and 20 micrograms/kg, respectively.
Mirakhur
R K
RK
Gibson
F M
FM
Ferres
C J
CJ
D000328:Adult; D000704:Analysis of Variance; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004357:Drug Synergism; D006801:Humans; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage*; D010197:Pancuronium / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014403:Tubocurarine / Q000008:administration & dosage*; D014673:Vecuronium Bromide
D004338:Drug Combinations; D009466:Neuromuscular Blocking Agents; D014673:Vecuronium Bromide; D010197:Pancuronium; D014403:Tubocurarine