title: Primary tumours of the thymus in the rat.
abstract: The features of 192 primary thymic tumours occurring in the rat are described. Of these neoplasms, 170 were classified as benign thymomas, one as a benign fibrous histiocytoma, 20 as various types of malignant thymoma, 3 lympho-epithelioma-like carcinomas, one mixed small cell undifferentiated-squamous cell carcinoma, one sarcoma-like carcinoma, 4 undifferentiated carcinomas, 11 squamous cell carcinomas and the one remaining tumour as a carcinoid. A mouse, anti-epithelial, monoclonal antibody, lu-5, was used to confirm the epithelial nature of the malignant thymomas, and neuron-specific enolase to confirm the diagnosis of carcinoid. The tumours showed many features in common with those reported in man.
authors.affiliation: Department of Toxicological Pathology, Ciba-Geigy AG, Basel, Switzerland.
authors.forename: D C
authors.initials: DC
authors.lastname: Naylor
authors.forename: G J
authors.initials: GJ
authors.lastname: Krinke
authors.forename: H J
authors.initials: HJ
authors.lastname: Ruefenacht
mesh_terms: D000818:Animals; D002276:Carcinoid Tumor / Q000145:classification / Q000473:pathology / Q000662:veterinary; D002277:Carcinoma / Q000145:classification / Q000473:pathology / Q000662:veterinary; D018219:Histiocytoma, Benign Fibrous / Q000145:classification / Q000473:pathology / Q000662:veterinary; D051381:Rats; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000145:classification* / Q000473:pathology; D013945:Thymoma / Q000145:classification / Q000473:pathology / Q000662:veterinary; D013953:Thymus Neoplasms / Q000145:classification / Q000473:pathology / Q000662:veterinary*