title: [Identification of alpha-2 adrenergic receptors in rabbit adipocytes].
abstract: Adrenaline, an alpha and beta adrenergic agonist don't modify theophylline induced lipolysis in perirenal and epididymal adipose tissue of the rabbit. Clonidine an alpha 2 adrenergic agonist inhibits theophylline stimulated lipolysis in the two tissue indicating the existence of alpha 2 adrenergic responsiveness. Direct identification of these receptors by radioligand binding studies shows that (H3) yohimbine an alpha 2 adrenergic antagonist binds to rabbit's fat cell membranes with high affinity: KD = 1.7 +/- 0.1 nmoles. The maximal number of binding sites at saturation is low 16 +/- 29 fmoles/mg protein.
authors.affiliation: Institut National de Nutrition de Tunis, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Nasraoui
authors.forename: R
authors.initials: R
authors.lastname: Rozen
authors.forename: M
authors.initials: M
authors.lastname: Apfelbaum
mesh_terms: D000273:Adipose Tissue / Q000032:analysis* / Q000166:cytology / Q000187:drug effects; D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D011942:Receptors, Adrenergic, alpha / Q000032:analysis* / Q000187:drug effects; D013806:Theophylline / Q000494:pharmacology*; D015016:Yohimbine / Q000494:pharmacology*
chemical_list: D011942:Receptors, Adrenergic, alpha; D015016:Yohimbine; D013806:Theophylline; D003000:Clonidine; D004837:Epinephrine
vernacular_title: Identification des récepteurs alpha 2 adrénergiques sur les adipocytes de lapin.