Phorbol esters mimic alpha-Adrenergic potentiation of serotonin N-acetyltransferase induction in the rat pineal.
alpha-Adrenergic stimulation of the rat pineal gland is known to stimulate phosphatidylinositol turnover and to potentiate the induction of serotonin N-acetyltransferase (SNAT) activity evoked by submaximal beta-adrenergic stimulation. In some (other) systems tumor-promoting phorbol esters are known to mimic physiologic stimulation and to enhance specifically the activity of protein kinase C. Here it is shown that phorbol esters specifically mimic the potentiating effect of alpha-adrenergic stimulation on SNAT activity in the rat pineal. These effects contribute to the argument for a role for phosphatidylinositol turnover and protein kinase C in mediating alpha-adrenergic stimulation.
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D000123:Acetyltransferases / Q000096:biosynthesis*; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D007545:Isoproterenol / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology; D015240:Phorbol 12,13-Dibutyrate; D010703:Phorbol Esters / Q000494:pharmacology*; D010704:Phorbols / Q000494:pharmacology*; D010870:Pineal Gland / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D000316:Adrenergic alpha-Agonists; D010703:Phorbol Esters; D010704:Phorbols; D010656:Phenylephrine; C008874:phorbol-12,13-diacetate; D015240:Phorbol 12,13-Dibutyrate; C011003:isolevin; D000123:Acetyltransferases; D001191:Arylamine N-Acetyltransferase; D007545:Isoproterenol