Effect of lidamidine, a proposed alpha 2-adrenoreceptor agonist, on salt and water transport in human jejunum.
The effects of a new antidiarrheal agent, lidamidine (10 mg per os) and an identical placebo on jejunal fluid and electrolyte transport in vivo were investigated in five normal volunteers during steady-state perfusion of a 25-cm length of jejunum with a plasma-like solution. Studies were carried out under basal conditions and during secretion stimulated by incorporation of prostaglandin E2 (5 X 10(-6) M) in the infusate. Lidamidine had no significant effect on jejunal fluid transport under basal conditions but reduced secretion induced by prostaglandin E2 (P less than 0.05).
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D000316:Adrenergic alpha-Agonists / Q000009:adverse effects / Q000494:pharmacology*; D000328:Adult; D001692:Biological Transport / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001834:Body Water / Q000187:drug effects / Q000378:metabolism*; D003967:Diarrhea / Q000139:chemically induced; D015232:Dinoprostone; D004573:Electrolytes / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010671:Phenylurea Compounds / Q000009:adverse effects / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011674:Pulse / Q000187:drug effects; D013997:Time Factors
D000316:Adrenergic alpha-Agonists; D004573:Electrolytes; D010671:Phenylurea Compounds; D011458:Prostaglandins E; D015232:Dinoprostone; C020918:lidamidine