title: Interaction between atrial natriuretic factor and angiotensin II receptors in the regulation of blood pressure.
abstract: Atrial natriuretic factor (ANF) and angiotensin II (Ang II) appear to act as physiological antagonists in the regulation of blood pressure and fluid homeostasis. After 18 h incubation in cultured vascular smooth muscle cells, Ang II (10(-8) mol/l) induced down-regulation of ANF receptors (reduced by 60% of total binding capacity) that was inhibited by Sar1-Ile8-Ang II (10(-7) mol/l), whereas ANF (10(-8), 10(-7) mol/l) was not able to affect Ang II receptors. The down-regulation provoked by Ang II was associated with an enhancement of ANF-stimulated cyclic (c) GMP formation and was confined to the non-guanylate cyclase-coupled ANF receptor subtype. This suggests that the decrease in ANF receptors elicited by Ang II and the paradoxical increase in the biological activity of ANF may represent a mechanism that represses excessive or long-term pressor effects of Ang II.
authors.affiliation: Institut Henri Beaufour Research Laboratories, Les Ulis, France.
authors.forename: P E
authors.initials: PE
authors.lastname: Chabrier
authors.forename: P
authors.initials: P
authors.lastname: Roubert
authors.forename: M O
authors.initials: MO
authors.lastname: Longchamps
authors.forename: P
authors.initials: P
authors.lastname: Plas
authors.forename: P
authors.initials: P
authors.lastname: Braquet
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001011:Aorta; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure; D006152:Cyclic GMP / Q000378:metabolism; D004789:Enzyme Activation; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D051381:Rats; D011945:Receptors, Angiotensin / Q000502:physiology*; D017461:Receptors, Atrial Natriuretic Factor; D011956:Receptors, Cell Surface / Q000502:physiology*
chemical_list: D011945:Receptors, Angiotensin; D011956:Receptors, Cell Surface; D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D017461:Receptors, Atrial Natriuretic Factor; D006152:Cyclic GMP