Inhibition of human lymphocyte cyclic nucleotide phosphodiesterases by the chlorinated adenosine analog DTA-35.
Human (E+)-T-lymphocytes have multiple cyclic nucleotide phosphodiesterase activities, some of which are markedly inhibited by the chlorinated adenosine derivative 9-(3',5'-dichloro-2',3',5'-trideoxy-beta-D-threo-pentofuranosyl)adenine (DTA-35).
Hurwitz
M Y
MY
Department of Biochemistry, University of Minnesota, Minneapolis 55455.
Hurwitz
R L
RL
Edstrom
R D
RD
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D003839:Deoxyadenosines / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000201:enzymology* / Q000276:immunology
D003839:Deoxyadenosines; C059947:DTA 35; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D015106:3',5'-Cyclic-GMP Phosphodiesterases