Functional beta 2-adrenoceptors in right atria isolated from footshock-stressed rats.
The participation of beta 2-adrenoceptors in the chronotropic response was evaluated in right atria isolated from rats submitted to daily footshock stress for three days. Footshock increased both the sensitivity to salbutamol and the pA2 of butoxamine. These results provide additional support for the proposal that repeated footshock stress increases the function of rat atrial postjunctional beta 2-adrenoceptors.
Bassani
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RA
Departamento de Farmacologia, Faculdade de Ciências Medicas, Campinas, SP, Brasil.
de Moraes
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S
D000420:Albuterol / Q000378:metabolism; D000818:Animals; D016275:Atrial Function; D002078:Butoxamine / Q000378:metabolism; D006339:Heart Rate; D007537:Isometric Contraction; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D013312:Stress, Physiological / Q000503:physiopathology*
D011943:Receptors, Adrenergic, beta; D002078:Butoxamine; D000420:Albuterol