title: Influence of ganglioside treatment on acrylamide neuropathy in mice. A morphometric study.
abstract: Female CBA/J mice were given oral doses of 40 mg/kg acrylamide 3 times weekly for 7 or 11 weeks in order to induce peripheral neuropathy. Half the animals were concurrently treated with 20 mg/kg, subcutaneously, of a ganglioside mixture (Cronassial). The other half received physiological saline and served as control. At the end of 7 or 11 weeks, the tibial nerves were removed and examined histomorphometrically. Every animal had developed a neuropathy. However, the mice treated with the ganglioside mixture showed on both the examination dates a substantially larger proportion of small sprouting nerve fibres than the control. It was concluded from this that treatment with gangliosides stimulated the regenerative potential of the damaged nerves.
authors.affiliation: Department of Toxicology/Experimental Pathology, Dr. Madaus GmbH & Co., Cologne, Fed. Rep. of Germany.
authors.forename: C D
authors.initials: CD
authors.lastname: Stotzem
authors.forename: U
authors.initials: U
authors.lastname: Mengs
authors.forename: K P
authors.initials: KP
authors.lastname: Odenthal
mesh_terms: D000178:Acrylamides; D000818:Animals; D005260:Female; D005732:Gangliosides / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D008808:Mice, Inbred CBA; D009416:Nerve Regeneration / Q000187:drug effects*; D010525:Peripheral Nerves / Q000473:pathology / Q000503:physiopathology*; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000473:pathology; D013979:Tibial Nerve / Q000473:pathology / Q000503:physiopathology*
chemical_list: D000178:Acrylamides; D005732:Gangliosides