[3H]imipramine binding sites are decreased in platelets of chronic pain patients.
Tritiated imipramine binding to whole platelets was measured in 16 chronic pain patients not suffering from major depression and in a control group. Maximum binding was significantly lower in chronic pain patients than in the control group, whereas the binding affinity was not significantly different.
Magni
G
G
Department of Psychiatry, University of Padua School of Medicine, Italy.
Andreoli
F
F
Arduino
C
C
Arsié
D
D
Ceccherelli
F
F
Ambrosio
F
F
Eandi
M
M
D001792:Blood Platelets / Q000032:analysis*; D002352:Carrier Proteins; D002908:Chronic Disease; D003863:Depression / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000097:blood*; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000032:analysis*
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor