The effect of peripherally administered GABA on noradrenaline-induced reflex vagal bradycardia in urethane anaesthetized rats.
Intravenously administered GABA significantly reduced the size of noradrenaline-induced reflex vagal bradycardia without affecting blood pressure increase. Intravenously administered GABA reduced bradycardia elicited by stimulation of preganglionic fibres in the vagus nerve. These findings provide evidence suggesting that, in addition to its well known effects on structures regulation cardiovascular function at CNS level GABA could modulate baroreceptor reflex(es) by acting at a peripheral site.
Maggi
C A
CA
Giuliani
S
S
Meli
A
A
D000758:Anesthesia; D000818:Animals; D004347:Drug Interactions; D004558:Electric Stimulation; D006339:Heart Rate / Q000187:drug effects*; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007275:Injections, Intravenous; D008297:Male; D009638:Norepinephrine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000187:drug effects; D013654:Taurine / Q000031:analogs & derivatives / Q000494:pharmacology; D014520:Urethane; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology*
D006584:Hexamethonium Compounds; D013654:Taurine; D018738:Hexamethonium; D014520:Urethane; D005680:gamma-Aminobutyric Acid; C001355:tramiprosate; D009638:Norepinephrine; D010646:Phentolamine