Inhibitory influences of envelope glycoproteins of HIV-1 on normal immune responses.
Infection with the human immunodeficiency virus (HIV-1) leads to a wide range of immunological abnormalities. We have shown that native envelope glycoproteins (gp120) of HIV-1 inhibit antigen-specific and anti-CD3 induced lymphoproliferation of normal lymphocytes. We have demonstrated that gp120 binds to CD4 positive T lymphocytes and is internalized. These studies suggest that interaction of gp120 with the CD4 receptor may be sufficient to inhibit antigen-specific T cell responses that are mediated via the CD3-Ti receptor complex. Such an event could represent another mechanism by which the overall immune function of the CD4 positive T lymphocyte is depressed and may be relevant in planning investigations on the ongoing vaccine trial involving envelope glycoproteins.
Chirmule
N
N
Department of Pediatrics, North Shore University Hospital, Cornell University Medical College, Manhasset, NY 11030.
Kalyanaraman
V
V
Oyaizu
N
N
Pahwa
S
S
D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D017252:CD3 Complex; D015483:HIV Antibodies / Q000276:immunology; D015699:HIV Envelope Protein gp120; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation / Q000187:drug effects; D008934:Mitogens / Q000494:pharmacology; D009183:Mycotoxins / Q000494:pharmacology; D011485:Protein Binding; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D015728:Receptors, HIV; D011991:Receptors, Virus / Q000187:drug effects / Q000276:immunology; D012191:Retroviridae Proteins / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D013745:Tetanus Toxoid / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014373:Tuberculin / Q000494:pharmacology
D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120; D008934:Mitogens; D009183:Mycotoxins; D011948:Receptors, Antigen, T-Cell; D015728:Receptors, HIV; D011991:Receptors, Virus; D012191:Retroviridae Proteins; D013745:Tetanus Toxoid; D014373:Tuberculin; D013936:Thymidine