[Restoration of neuromuscular transmission in the rat diaphragm after the action of an organophosphorus inhibitor of acetylcholinesterase by using curare].
The acetylcholinesterase phospho-organic inhibitor armine (4.10(-7) M) reduces the muscle response to a single nerve stimulus (up to 50%) and the nerve-induced tetanic tension in the rat phrenic-diaphragm muscle preparation. Tubocurarine exerts a similar effect. Substitution of armine by 0.5.10(-7) or 1.10(-7) M tubocurarine for 60-90 min leads to almost complete restoration of neuromuscular transmission. In the presence of armine, tubocurarine exerts a considerably lesser effect. Possible pre- and post-synaptic mechanisms of the tubocurarine action, are discussed.
Krivoĭ
I I
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D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001138:Armin / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D003472:Curare / Q000494:pharmacology*; D003964:Diaphragm / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors; D014403:Tubocurarine / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D003472:Curare; D001138:Armin; D014403:Tubocurarine
Vosstanovlenie nervno-myschechnoĭ peredachi v diafragme krysy posle deĭstviia fosfororganicheskogo ingibitora atsetilkholinésterazy s pomoshch'iu kurare.