Mutagenicity of inhaled anesthetics in Drosophila melanogaster.
The mutagenic effects of several inhaled anesthetic agents were investigated using the sex-linked recessive lethal assay in the fruit fly, Drosophila melanogaster. Male wild-type flies were exposed for 1 hr to either halothane, enflurane, isoflurane, or fluroxene at vapor concentrations of 1 or 2% or to nitrous oxide at concentrations of 40 or 80%. Control flies were exposed to air alone. Following treatment, male flies were mated with untreated virgin females of the Basc strain and the rate of sex-linked recessive lethals was determined in the F2 generation. Halothane and fluroxene produced a dose-dependent and statistically significant increase in the rate of sex-linked recessive lethals, whereas enflurane, isoflurane, and nitrous oxide were not mutagenic at the concentrations tested.
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D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000633:toxicity*; D000818:Animals; D004331:Drosophila melanogaster; D004737:Enflurane / Q000633:toxicity; D004987:Ethers / Q000633:toxicity; D005804:Genes, Lethal / Q000187:drug effects; D005808:Genes, Recessive / Q000187:drug effects; D006221:Halothane / Q000633:toxicity; D007530:Isoflurane / Q000633:toxicity; D008297:Male; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D009609:Nitrous Oxide / Q000633:toxicity
D000777:Anesthetics; D004987:Ethers; D009153:Mutagens; D004737:Enflurane; D007530:Isoflurane; D009609:Nitrous Oxide; D006221:Halothane