Itraconazole activity against fungal germination.
Itraconazole was found to be superior to ketoconazole in its antifungal activity in vitro against Hyphomycetes and Candida. In particular, complete inhibition of germination of Candida albicans and Aspergillus spp. by a lower dose of itraconazole can explain the better activity in vivo of this drug.
Strippoli
V
V
Institute of Microbiology, University of Rome La Sapienza, Italy.
Simonetti
N
N
Retico
A
A
Lucchetti
G
G
D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects / Q000254:growth & development*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development*; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives* / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000187:drug effects
D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole