title: Osteoporosis of pregnancy.
abstract: Eight women with pregnancy-associated osteoporosis were studied for up to ten years. Back pain and vertebral collapse usually occurred in the first pregnancy and did not recur in two subsequent pregnancies. Except in one patient, bone histology showed no increase in resorption. Plasma concentrations of 1,25-dihydroxyvitamin D tended to be low whereas those of calcitonin were, with one exception, normal. It is suggested that in these patients there may have been a transient failure of the usual changes in calciotropic hormones to prepare the maternal skeleton for the stress of childbirth. However, subsequent pregnancies in such patients are not necessarily contraindicated.
authors.forename: R
authors.initials: R
authors.lastname: Smith
authors.forename: J C
authors.initials: JC
authors.lastname: Stevenson
authors.forename: C G
authors.initials: CG
authors.lastname: Winearls
authors.forename: C G
authors.initials: CG
authors.lastname: Woods
authors.forename: B P
authors.initials: BP
authors.lastname: Wordsworth
mesh_terms: D000328:Adult; D001842:Bone and Bones / Q000473:pathology; D002116:Calcitonin / Q000097:blood; D002117:Calcitriol / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010024:Osteoporosis / Q000097:blood / Q000473:pathology; D010281:Parathyroid Hormone / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000473:pathology
chemical_list: D010281:Parathyroid Hormone; D002116:Calcitonin; D002117:Calcitriol