[Toxic hemolytic anemia in the newborn infant following ingestion of a phenazone derivative (Cibalgin) via breast milk].
After the administration of Cibalgin (a Phenazone-derivative) to a lactating mother during the first days after delivery, her healthy newborn infant developed a toxic hemolytic anemia with precipitation of globin, forming large inclusion bodies in the erythrocytes. Phenazone was found in the mothers milk up to 8 days after the end of Cibalgin administration. During the acute phase of hemolysis it could also be demonstrated in the infants serum. A list of medicaments that pass into the milk and can cause a toxic hemolytic anemia in the child is included.
Frei
H
H
Bühlmann
U
U
Rudin
O
O
D000632:Aminopyrine / Q000009:adverse effects* / Q000378:metabolism; D000743:Anemia, Hemolytic / Q000139:chemically induced*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000378:metabolism; D000983:Antipyrine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism; D001463:Barbiturates / Q000009:adverse effects* / Q000378:metabolism; D001663:Bilirubin / Q000097:blood; D001942:Breast Feeding; D004338:Drug Combinations / Q000009:adverse effects / Q000378:metabolism; D006452:Hemoglobinometry; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000139:chemically induced*; D008297:Male; D008895:Milk, Human / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001463:Barbiturates; D004338:Drug Combinations; D000632:Aminopyrine; C018538:eunalgit; C009077:propyphenazone; D001663:Bilirubin; D000983:Antipyrine
Toxische hämolytische Anämie beim Neugeborenen nach Ingestion eines Phenazon-Derivates (Cibalgin) via Muttermilch.