Prospective study of cancer in patients with hypogammaglobulinaemia.
Among 377 patients with primary hypogammaglobulinaemia, mainly common variable immunodeficiency (CVID), 316 patients survived the first 2 years after diagnosis and were the subject of a study of cancer incidence. Among the 220 patients with CVID, there was a 5-fold increase of cancer due mainly to large excesses of stomach cancer (47-fold) and lymphomas (30-fold). The excess of stomach cancer is probably related to the high frequency of achlorhydria in CVID. 3 of the 7 patients with stomach cancer and CVID survived for 5 years or longer.
Kinlen
L J
LJ
Webster
A D
AD
Bird
A G
AG
Haile
R
R
Peto
J
J
Soothill
J F
JF
Thompson
R A
RA
D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications*; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008223:Lymphoma / Q000453:epidemiology / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000401:mortality; D011379:Prognosis; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000401:mortality