title: [Effect of a decrease in perfusion pressure on the alpha-adrenergic reactions of the coronary vessels].
abstract: Acute dog experiments involving the perfusion of donor coronary arteries demonstrated that alpha-adrenoreceptor stimulation in the presence of a beta-adrenergic block resulted in a 30% drop of coronary flow. This response is maintained at low perfusion coronary blood pressure values (up to 25 +/- 13 mmHg, p less than 0.02), whereas coronary dilatation reserve is already fully depleted at 60 +/- 8 mmHg, suggesting that the degree of coronary arterial stenosis associated with coronary insufficiency may be a decisive factor shaping coronary response to alpha-adrenoreceptor stimulation.
authors.forename: E B
authors.initials: EB
authors.lastname: Novikova
authors.forename: L I
authors.initials: LI
authors.lastname: Serebriakova
authors.forename: O V
authors.initials: OV
authors.lastname: Tskitishvili
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology*; D004285:Dogs; D005260:Female; D006940:Hyperemia / Q000503:physiopathology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010477:Perfusion; D011433:Propranolol / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D011942:Receptors, Adrenergic, alpha; D011433:Propranolol; D007545:Isoproterenol; D009638:Norepinephrine
vernacular_title: Vliianie snizheniia perfuzionnogo davleniia na al'fa-adrenergicheskie reaktsii koronarnykh sosudov.