Efficacies of four antifungal agents in experimental murine sporotrichosis.
Four antifungal agents, amphotericin B, SDZ 89-485, itraconazole, and terbinafine, were tested for efficacy in a murine model of systemic sporotrichosis. Survival in the groups treated with amphotericin B, SDZ 89-485, and itraconazole was significantly better than that of control infected mice. However, these agents did not wholly protect the infected mice, as tail and paw lesions, whole-body radiographs, and positive cultures from survivors showed evidence of dissemination. Terbinafine-treated mice had the same or poorer survival as control infected mice, despite documented drug absorption.
Kan
V L
VL
Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Bennett
J E
JE
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives / Q000627:therapeutic use; D051379:Mice; D009281:Naphthalenes / Q000627:therapeutic use; D013175:Sporothrix / Q000187:drug effects / Q000254:growth & development; D013174:Sporotrichosis / Q000188:drug therapy*; D000077291:Terbinafine; D014230:Triazoles / Q000627:therapeutic use
D000935:Antifungal Agents; D009281:Naphthalenes; D014230:Triazoles; C060176:SDZ 89-485; D017964:Itraconazole; D000666:Amphotericin B; D000077291:Terbinafine; D007654:Ketoconazole