Interactions between calcium entry blockers and vecuronium bromide in anaesthetized cats.
Possible interactions between three calcium entry blocking agents (nifedipine, verapamil and bepridil) and the non-depolarizing neuromuscular blocking agent, vecuronium bromide, were investigated in chloralose-anaesthetized cats. In i.v. doses which caused decreases in arterial pressure, the calcium entry blockers did not affect indirectly-elicited twitches of tibialis muscle, but did potentiate the effects of vecuronium. No such potentiation of vecuronium was observed with the vasodilator drug, sodium nitroprusside. Experiments using close-arterial injections of acetylcholine suggested that the probable site of interaction is on the postsynaptic muscle membrane and probably involves blockade of calcium channels in skeletal muscle.
Anderson
K A
KA
Marshall
R J
RJ
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D015764:Bepridil; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology; D013997:Time Factors; D014673:Vecuronium Bromide
D002121:Calcium Channel Blockers; D009466:Neuromuscular Blocking Agents; D011759:Pyrrolidines; D009599:Nitroprusside; D015764:Bepridil; D014673:Vecuronium Bromide; D010197:Pancuronium; D000109:Acetylcholine