title: Effect of diet particle size and feeding of H2-receptor antagonists on gastric ulcers in swine.
abstract: Four experiments were conducted to evaluate the effect of diet and the administration of H2-antagonists in feed on gastric ulcer formation and performance of growing-finishing swine. Pigs receiving a finely ground diet (less than lmm) grew faster (.73 vs .68 kg/d, P less than .01) and had better feed utilization (3.47 vs 3.76, P less than .01) than pigs receiving a cracked corn-based diet. Incidence of ulcers in the esophageal region of the stomach of pigs fed the finely ground diet was greater (P less than .01) than in pigs fed cracked corn. The average daily gain of pigs receiving the finely ground diet was inversely related to ulcer incidence (r = .403, P less than .01, df = 59). The addition of 5, 10, 20 or 100 ppm of the H2-antagonist, metiamide, or 6, 18 or 54 ppm of SK&F 93479 to the finely ground diet did not improve pig performance or affect the incidence of gastric ulceration. The addition of 2, 6 and 18 ppm of SK&F 93479 to a corn-soy diet containing 4.5% alfalfa meal caused a reduction in gastric ulceration (P less than .05) and improved feed utilization by 3.2% (P less than .05). These data suggest that finely ground diets improve the performance of growing-finishing swine, but increase the incidence of ulcers in the esophageal region of the stomach. Severe gastric ulceration adversely affects swine performance. Feeding H2-antagonists does not reduce the ulcerogenic properties of finely ground diets, suggesting factors other than gastric acid secretion are involved in ulcerogenesis. The use of H2-antagonists in corn-soy diets improves feed utilization and reduces ulceration.
authors.forename: R D
authors.initials: RD
authors.lastname: Hedde
authors.forename: T O
authors.initials: TO
authors.lastname: Lindsey
authors.forename: R C
authors.initials: RC
authors.lastname: Parish
authors.forename: H D
authors.initials: HD
authors.lastname: Daniels
authors.forename: E A
authors.initials: EA
authors.lastname: Morgenthien
authors.forename: H B
authors.initials: HB
authors.lastname: Lewis
mesh_terms: D000821:Animal Feed / Q000009:adverse effects; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005503:Food Additives; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008297:Male; D008785:Metiamide / Q000494:pharmacology*; D010316:Particle Size; D011744:Pyrimidinones / Q000494:pharmacology*; D013276:Stomach Ulcer / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D013552:Swine / Q000254:growth & development*; D013553:Swine Diseases / Q000453:epidemiology* / Q000209:etiology; D013890:Thiourea / Q000031:analogs & derivatives*
chemical_list: D005503:Food Additives; D006635:Histamine H2 Antagonists; D011744:Pyrimidinones; D008785:Metiamide; C033275:SK&F 93479; D013890:Thiourea