title: Cytolytic response of human T cells against allogeneic small cell lung carcinoma treated with interferon gamma.
abstract: Human lymphocytes stimulated in vitro by allogeneic small cell lung carcinoma cell lines did not show any significant cytolytic activity against the stimulator tumor cells. However, a high level of lysis was observed when both stimulator and target small cell lung carcinoma cells were pretreated with interferon gamma, which increased considerably the expression of major histocompatibility class I molecules by these cells. The demonstration that small cell lung carcinoma cells can be lysed by cytolytic T lymphocytes, suggests that it will be feasible to study the autologous T cell response of patients against this tumor.
authors.affiliation: Université Catholique de Louvain, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Weynants
authors.forename: P
authors.initials: P
authors.lastname: Wauters
authors.forename: P G
authors.initials: PG
authors.lastname: Coulie
authors.forename: B
authors.initials: B
authors.lastname: Van den Eynde
authors.forename: M
authors.initials: M
authors.lastname: Symann
authors.forename: T
authors.initials: T
authors.lastname: Boon
mesh_terms: D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D006680:HLA Antigens / Q000096:biosynthesis; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D007371:Interferon-gamma