[Isolated modification of the vascular system by vasopressor agents (akrinor, etilefrin, ephedrine, norfenefrine, amezinium) during extracorporeal circulation in man].
The influence of different vasopressors (Akrinor, etilefrine, ephedrine, norfenefrine, ameziniummetilsulfate) on arterial perfusion pressure and oxygenator volume during extracorporeal circulation was compared to a control group. All substances led to an increase in perfusion pressure, thus demonstrating a direct influence on arterial vessels. The rise in arterial pressure after injection of ameziniummetilsulfate persisted during the investigation period, whereas norfenefrine led to a short-lasting, but massive increase. No rise in venous tone was noticed during the investigation period.
Boldt
J
J
Müller
H
H
Börner
U
U
Kling
D
D
Moosdorf
R
R
Hempelmann
G
G
D015078:2-Hydroxyphenethylamine / Q000031:analogs & derivatives / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D004338:Drug Combinations / Q000494:pharmacology; D004809:Ephedrine / Q000494:pharmacology; D005039:Etilefrine / Q000494:pharmacology; D005112:Extracorporeal Circulation; D006801:Humans; D008875:Middle Aged; D009655:Octopamine / Q000031:analogs & derivatives*; D010100:Oxygen / Q000097:blood; D011724:Pyridazines / Q000494:pharmacology; D013806:Theophylline / Q000031:analogs & derivatives / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D004338:Drug Combinations; D011724:Pyridazines; D014662:Vasoconstrictor Agents; D009655:Octopamine; C000147:cafedrine, theodrenaline drug combination; D015078:2-Hydroxyphenethylamine; D013806:Theophylline; C005310:norfenefrine; D004809:Ephedrine; D010100:Oxygen; C027784:amezinium; D005039:Etilefrine
Untersuchung zur isolierten Beeinflussung des Gefässsystems durch verschiedene blutdrucksteigernde Medikamente (Akrinor, Etilefrin, Ephedrin, Norfenefrin, Amezinium) während der extrakorporalen Zirkulation beim Menschen.