[Comparative study of the effects of antibodies to S-100 protein and ouabain on neurons of Helix pomatia].
Ouabain, used in 5.10(-4) M concentration, elicits 12 +/- 5 mV (15 experiments) depolarization of membrane of snail Helix neurons. In 80% of experiments depolarization is not accompanied by changes in membrane conductance, in 20% of experiments the decrease of the membrane conductance is observed. Application of the antibodies to S-100 protein (their concentration in the micropipette being 0.05 mg/ml) induces similar effects. The effects of ouabain and antibodies to S-100 protein are not additive and the main difference in their action lies in the ability of the cell to recover the resting potential of the membrane in the solution containing ouabain.
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D000818:Animals; D000906:Antibodies / Q000008:administration & dosage*; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D006372:Helix, Snails / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D010042:Ouabain / Q000494:pharmacology*; D009418:S100 Proteins / Q000276:immunology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D000906:Antibodies; D009418:S100 Proteins; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase
Sravnitel'noe izuchenie éffektov antitel k belku S-100 i uabaina na neĭronakh vinogradnoĭ ulitki.