RO 15-4513 and FG 7142 reverse the reduction in social behavior caused by ethanol in mice.
Ethanol (2 g/kg) reduces the time spent in social interaction and increases locomotor activity of pairs of NIH Swiss mice. This study examined whether two benzodiazepine receptor inverse agonists, RO 15-4513 (3 mg/kg) and FG 7142 (30 mg/kg) are able to reverse these effects. Neither drug alone altered social behavior, but both significantly attenuated the effect of ethanol on social interaction. They did not affect the ethanol-induced increase in motor activity. Benzodiazepine receptor inverse agonists thus appear capable of antagonizing some, but not all of the behavioral effects of ethanol in this paradigm.
Hilakivi
L A
LA
Laboratory of Clinical Studies, National Institute of Alcohol Abuse and Alcoholism, Bethesda, MD 20892.
Lister
R G
RG
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001386:Azides / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects; D012919:Social Behavior
D001386:Azides; D002243:Carbolines; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D000431:Ethanol; C035874:FG 7142; C042957:Ro 15-4513