title: Effect of somatostatin on the proliferation of mouse spleen lymphocytes in vitro.
abstract: The effect of somatostatin on the spontaneous proliferation of mouse spleen lymphocytes was investigated in vitro. The rate of 3H-thymidine incorporation was used as an index of lymphocyte proliferation. Somatostatin in a concentration of 10(-7) M enhanced the lymphocyte proliferation and abolished the antiproliferative effect of rat hypothalamic extract. Lower concentrations of somatostatin slightly decreased the lymphocyte DNA synthesis.
authors.forename: M
authors.initials: M
authors.lastname: Pawlikowski
authors.forename: H
authors.initials: H
authors.lastname: Stepien
authors.forename: J
authors.initials: J
authors.lastname: Kunert-Radek
authors.forename: A V
authors.initials: AV
authors.lastname: Schally
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013004:Somatostatin / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology*; D013936:Thymidine / Q000378:metabolism
chemical_list: D013004:Somatostatin; D013936:Thymidine