[Early results of the treatment of chronic progressive forms of multiple sclerosis with cyclophosphamide and ACTH].
A group of 16 patients with chronic-progressing type of multiple sclerosis treated by intense immunosuppression (cyclophosphamide and ACTH) were followed-up for one year after completion of therapy. The results were compared with the observation of a control group of 16 patients with a similar type of multiple sclerosis. The choice of the type of therapy was done at random, and the results were assessed by a doctor who ignored the type of therapy used. In only a part of the observed cases stabilization of the disease process was observed, in a greater number in the cases treated with cyclophosphamide and ACTH than in the those treated with ACTH alone. However, the duration of follow-up is regarded as too short for reaching final conclusions regarding the effect of therapy on the course of this type of multiple sclerosis.
Wender
M
M
Katedry Neurologii AM w Poznaniu.
Tokarz-Kupczyk
E
E
Mularek
O
O
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage*; D000328:Adult; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D012074:Remission Induction; D013997:Time Factors
D003520:Cyclophosphamide; D000324:Adrenocorticotropic Hormone
Wczesne wyniki leczenia postaci przewlekle postepujacych stwardnienia rozsianego cyklofosfamidem i ACTH.