Highly potent and selective ligands for a new class H3 of histamine receptor.
The third histamine receptor was first indentified on brain neurons and seems to be present in other cells such as lung mast cells. Hence the novel and potent H3-receptor agonist (R) alpha-methylhistamine might find therapeutic applications in allergic diseases.
Arrang
J M
JM
Unité 109 de Neurobiologie et Pharmacologie, Centre Paul Broca de l'INSERM, Paris, France.
Garbarg
M
M
Lancelot
J C
JC
Lecomte
J M
JM
Pollard
H
H
Robba
M
M
Schunack
W
W
Schwartz
J C
JC
D000818:Animals; D008761:Methylhistamines; D010880:Piperidines; D011869:Radioligand Assay; D051381:Rats; D011968:Receptors, Histamine / Q000187:drug effects / Q000302:isolation & purification*; D018100:Receptors, Histamine H3
D008761:Methylhistamines; D010880:Piperidines; D011968:Receptors, Histamine; D018100:Receptors, Histamine H3; C052075:thioperamide