Hydatidiform mole and HLA. II. Compatibility between patient and conceptus.
In 52 conceptuses with known genomic origin, the HLA types expressed on whole villi and/or stromal cell cultures were compared with the HLA types of the patients. No preference for either HLA compatibility or incompatibility was found for androgenetic and paternally derived triploid conceptuses as a whole. Heterozygous, androgenetic, conceptuses, however, showed a trend towards preferential incompatibility, which may be of importance for their apparent greater risk for trophoblastic tumour. HLA antibodies were found in 19.2% of the women, i.e. in the range reported for molar as well as non-molar pregnancies. Non-HLA antibodies reacting with lymphocytes of the spouse and/or cells from the conceptus were observed.
Hansen
H E
HE
Institute of Forensic Genetics, Copenhagen, Denmark.
Vejerslev
L O
LO
Larsen
S O
SO
D003602:Cytotoxicity, Immunologic; D005260:Female; D005333:Fetus / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics* / Q000276:immunology; D008297:Male; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000453:epidemiology / Q000276:immunology; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000276:immunology
D006680:HLA Antigens