The effect of oxytocin and fragment (MIF-I) on the development of tolerance to hypothermic and hypnotic action of ethanol in the rat.
The daily pretreatment of rats with oxytocin (OXY) or MIF-I prior to ethanol (Et-OH) administration markedly altered the alcohol tolerance when tested on the fifth day of treatment. OXY (800 and 2400 nmole/kg SC) and MIF (800 nmole/kg SC) inhibited the development of tolerance to the hypnotic effect of Et-OH. MIF at this dose also inhibited the tolerance to the hypothermic effect. Only OXY in the dose of 800 nmole/kg suppressed hypothermia in an acute experiment with Et-OH and produced by itself hypothermia after acute administration (2400 nmole/kg). The tolerance to this last effect developed after four days of peptide treatment. The results indicate that OXY and MIF-I can influence the processes of development of tolerance to some central depressive effects of Et-OH in rats.
Puciłowski
O
O
Kostowski
W
W
Trzaskowska
E
E
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D004361:Drug Tolerance / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D009075:MSH Release-Inhibiting Hormone / Q000494:pharmacology*; D008297:Male; D010121:Oxytocin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects
D000431:Ethanol; D010121:Oxytocin; D009075:MSH Release-Inhibiting Hormone