[The cholinergic system of the forebrain modulates the activity of the GABA-ergic interneurons which realize presynaptic regulation in the neocortex of kittens].
It has been found that at the end of the second week of postnatal life, stimulation of cholinergic ascending paths causes a selective inhibition of cortical neurones reaction to sensory stimulation, without influencing the background activity. The observed inhibition is blocked both by atropine and picrotoxin, but not by bicuculline. It is suggested that the observed phenomenon characterizes, presynaptic control of cortical neurones activity in the early ontogenesis. This inhibition is formed on the basis of cooperative choline- and GABA-ergic brain systems participation and is performed not through GABA-receptors.
Raevskiĭ
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VV
Budko
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KP
Mares
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P
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002415:Cats; D004558:Electric Stimulation; D007395:Interneurons / Q000187:drug effects / Q000502:physiology*; D009433:Neural Inhibition / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D013003:Somatosensory Cortex / Q000187:drug effects / Q000502:physiology*; D013377:Substantia Innominata / Q000187:drug effects / Q000502:physiology; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects
D011950:Receptors, Cholinergic; D011963:Receptors, GABA-A; D017981:Receptors, Neurotransmitter
Kholinergicheskaia sistema perednego mozga moduliruet aktivnost' GAMKergicheskikh interneĭronov, osushchestvliaiushchikh presinapticheskuiu reguliatsiiu v neokortekse u kotiat.