A single rat genomic DNA fragment encodes both the oxytocin and vasopressin genes separated by 11 kilobases and oriented in opposite transcriptional directions.
An 18 kb DNA fragment, containing the genes encoding both the vasopressin and oxytocin polyprotein precursors, has been isolated from a rat genomic library. The two genes are linked by approximately 11 kb of intervening sequence and transcribed from opposite DNA strands.
Mohr
E
E
Institut für Zellbiochemie und klinische Neurobiologie, Universitäts-Krankenhaus Eppendorf, Hamburg, F.R.G.
Schmitz
E
E
Richter
D
D
D000818:Animals; D010582:Bacteriophage lambda / Q000235:genetics; D004247:DNA / Q000235:genetics*; D004262:DNA Restriction Enzymes; D004274:DNA, Recombinant; D009693:Nucleic Acid Hybridization; D010121:Oxytocin / Q000235:genetics*; D011498:Protein Precursors / Q000235:genetics*; D051381:Rats; D014158:Transcription, Genetic; D014667:Vasopressins / Q000235:genetics*
D004274:DNA, Recombinant; D011498:Protein Precursors; D014667:Vasopressins; D010121:Oxytocin; D004247:DNA; D004262:DNA Restriction Enzymes