Essential immunogens in human pertussis: the role of fimbriae.
After the decline in pertussis vaccination in Britain from the mid-1970s, isolates possessing agglutinogen 2 (types 1.2.3 and 1.2) have replaced type 1.3 as the predominant serotypes. These agglutinogen-2 strains are fimbriate, and their predominance in non-vaccinated communities may result from enhanced attachment to mucosal cells. However, type 1.3 cells are not fimbriate; and, because agglutinogen 3 is essential in fully effective whole-cell vaccine, a subcellular vaccine prepared from fimbriae alone (agglutinogen 2) would probably be inadequate. The mouse can be killed with type 1 strains, devoid of agglutinogens 2 and 3, and is therefore not a suitable model for ensuring that pertussis vaccine contains these essential immunogens.
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D000942:Antigens, Bacterial / Q000276:immunology*; D001886:Bordetella pertussis / Q000145:classification / Q000276:immunology* / Q000302:isolation & purification; D010861:Fimbriae, Bacterial / Q000276:immunology*; D006801:Humans; D010567:Pertussis Vaccine / Q000276:immunology*; D012703:Serotyping; D013045:Species Specificity; D014917:Whooping Cough / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control
D000942:Antigens, Bacterial; D010567:Pertussis Vaccine