Inhibition of cholecystokinin response in the gallbladder by dibenamine and its protection by benzodiazepines.
The contractile response of the guinea-pig gallbladder to cholecystokinin (CCK) and acetylcholine (ACh) was irreversibly inhibited by 5 X 10(-5) M dibenamine, and the dibenamine-induced inhibition in the CCK response was prevented by 10(-4) M chlordiazepoxide (CDP) and diazepam (DZP), but not by 10(-2) M proglumide or 10(-6) M atropine. The dibenamine-induced inhibition in the ACh response was prevented by 10(-6) M atropine, but not by 10(-4) M CDP. These findings suggest that the binding of CCK to the CCK receptor can be inhibited by benzodiazepines.
Kubota
K
K
Sugaya
K
K
Fujii
F
F
Itonaga
M
M
Sunagane
N
N
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D001569:Benzodiazepines; D002766:Cholecystokinin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D003983:Dibenzylchlorethamine / Q000494:pharmacology*; D005704:Gallbladder / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D011377:Proglumide / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D003983:Dibenzylchlorethamine; D001285:Atropine; D002766:Cholecystokinin; D011377:Proglumide