title: A comparison of the sequestration of cadmium and zinc in the tissues of rainbow trout (Salmo gairdneri) following exposure to the metals singly or in combination.
abstract: Rainbow trout were exposed to either cadmium (9 micrograms/l) or zinc (100 micrograms/l) in their aquarium water. They were then transferred to water containing concentrations of cadmium (54 micrograms/l) that would have otherwise proved fatal to the majority of the fish without the pretreatment. Most of the fish survived under both sets of conditions. However, two different mechanisms seem to be involved in the protection of the animals against the toxic manifestations of cadmium. In both cases, more than 99% of the total body load of cadmium was found in the liver, kidney and gills of the animals. Analysis of the metal-binding proteins in these organs was carried out. In the fish exposed to the two concentrations of cadmium, the toxic metal was found only in association with two low mol. wt specific binding proteins despite the presence of zinc- (and copper)-containing isometallothioneins in all three organs. On the other hand, cadmium was distributed between these binding-proteins and metallothioneins in the liver, kidney and gill of the trout pretreated with zinc before their exposure to cadmium.
authors.forename: D G
authors.initials: DG
authors.lastname: Thomas
authors.forename: M W
authors.initials: MW
authors.lastname: Brown
authors.forename: D
authors.initials: D
authors.lastname: Shurben
authors.forename: J F
authors.initials: JF
authors.lastname: Solbe
authors.forename: A
authors.initials: A
authors.lastname: Cryer
authors.forename: J
authors.initials: J
authors.lastname: Kay
mesh_terms: D000818:Animals; D002104:Cadmium / Q000378:metabolism*; D004347:Drug Interactions; D008668:Metallothionein / Q000378:metabolism; D011485:Protein Binding; D012487:Salmonidae / Q000378:metabolism*; D014018:Tissue Distribution; D014337:Trout / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism*
chemical_list: D002104:Cadmium; D008668:Metallothionein; D015032:Zinc