Pharmacological actions of ifenprodil in the rat isolated anococcygeus muscle.
The effect of ifenprodil on the contractile responses of the rat anococcygeus muscle to noradrenaline, methoxamine, carbachol, potassium chloride and calcium chloride has been examined. Ifenprodil (10(-8)-10(-7) M) non-competitively antagonized noradrenaline and methoxamine-induced contractions while carbachol-induced responses were unaffected. Similarly, contractile responses to KCl (in tissues from reserpinized animals, or tissues bathed in Tyrode containing 10(-6) M phentolamine) and CaCl2 in tissues bathed with Ca2+-free depolarizing solution were blocked non-competitively by ifenprodil (10(-7)-10(-6) M). These findings suggest that ifenprodil possesses alpha-adrenoceptor antagonist activity, with intrinsic Ca2+ blocking properties.
Adeagbo
A S
AS
Magbagbeola
A O
AO
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D002122:Calcium Chloride / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D010880:Piperidines; D014665:Vasodilator Agents; D011189:Potassium Chloride; D002217:Carbachol; D008729:Methoxamine; D002122:Calcium Chloride; C010739:ifenprodil; D009638:Norepinephrine