A two-week treatment with antidepressants does not increase the density of 3H-prazosin binding sites in the cerebral cortex of elderly rats.
The effect of repeated administration of antidepressants (imipramine, amitriptyline, citalopram) on the 3H-prazosin binding to alpha 1-adrenoceptors in the cerebral cortex of elderly (12-14-month old) rats was studied. Additionally, the effect evoked by imipramine was also studied in their young (2-3-month old) counterparts. Imipramine increased the Bmax value by 27% in young animals, while imipramine, amitriptyline and citalopram did not change the 3H-prazosin binding (Bmax, KD) in elderly rats. The obtained results demonstrate that the ability of antidepressants to increase the number of alpha 1-adrenoceptors in the rat cerebral cortex disappears with age.
Nowak
G
G
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
D000375:Aging / Q000378:metabolism*; D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D015283:Citalopram / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D011224:Prazosin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D000928:Antidepressive Agents; D011942:Receptors, Adrenergic, alpha; D015283:Citalopram; D000639:Amitriptyline; D007099:Imipramine; D011224:Prazosin