[Effect of serotonin on the activity of the neurons involved in the realization of the avoidance reflex of the snail].
Bath application of 10(-5) mol/l of serotonin (5-HT) elicited a 50% increase of summary EPSPs recorded in command neurones for avoidance behaviour. No significant changes of rest potential and input resistance were seen in these cells. 5-HT evoked an increase of spontaneous level of firing in motoneurones involved in the same reflex, as well as an increase in the number of spikes which paralleled increase of EPSPs to the same stimulus in command neurones. In sensory cells, presynaptic to the command neurones, application of 5-HT evoked a significant increase of excitability and of input resistance. Monosynaptic EPSPs recorded in the command neurones showed a 40% increase after serotonin application. It is concluded that the major locus of plastic changes evoked by 5-HT application in the neuronal chain underlying avoidance reflex is the synaptic contact between sensory and command neurones.
Chistiakova
M V
MV
Balaban
P M
PM
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D009473:Neuronal Plasticity / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects*; D012018:Reflex / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology*; D012908:Snails / Q000187:drug effects*; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D012701:Serotonin
Vliianie serotonina na aktivnost' neĭronov, vkliuchennykh v osushchestvlenie oboronitel'nogo refleksa ulitki.