The effects of peripherally administered monoaminergic drugs on ethanol diuresis in rats.
The effect of peripherally administered drugs that modify monoaminergic function, on ethanol (2.0 g kg-1, intragastrically)-induced changes in urine output has been examined in rats. The alpha-noradrenoceptor agonist, clonidine (0.05-0.15 mg kg-1) produced marked urine output and potentiated slightly the diuretic effect of ethanol. The alpha-noradrenoceptor antagonist, phentolamine (1-5 mg kg-1) dose-dependently decreased ethanol-induced diuresis. p-Chloroamphetamine (0.8-2.0 mg kg-1) produced significant diuresis and potentiated the diuresis produced by ethanol. Methysergide (1.25, 2.5 mg kg-1), a 5-hydroxytryptamine receptor antagonist, had no effect on urine output while it depressed the ethanol-induced increase in urine output. Apomorphine (0.8, 1.5 mg kg-1), a dopamine receptor agonist, did not modify urine output in either control or ethanol-treated animals, while the dopamine receptor antagonist, pimozide (0.75-3.0 mg kg-1), dose-dependently decreased ethanol-induced diuresis, but had no effect on urine output in control animals. Since our previous research indicates that the intraventricular administration of drugs that alter dopaminergic and 5-HT function does not alter ethanol-induced diuresis, the interaction of these types of agents with ethanol-induced diuresis in the present study suggests that the interaction was mediated peripherally.
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D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001337:Autonomic Agents / Q000494:pharmacology*; D003000:Clonidine / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects*; D004347:Drug Interactions; D000431:Ethanol / Q000037:antagonists & inhibitors / Q000097:blood / Q000494:pharmacology*; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D010868:Pimozide / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D010133:p-Chloroamphetamine / Q000494:pharmacology
D001337:Autonomic Agents; D010868:Pimozide; D000431:Ethanol; D010133:p-Chloroamphetamine; D003000:Clonidine; D001058:Apomorphine; D008784:Methysergide; D010646:Phentolamine