title: Absorption of eicosapentaenoic acid and docosahexaenoic acid from fish oil triacylglycerols or fish oil ethyl esters co-ingested with a high-fat meal.
abstract: The absorption of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from fish oil triacylglycerols and fish oil ethyl esters consumed in a high-fat meal (44 g total fat) by male volunteers was measured and compared to values previously reported for consumption in a low-fat meal (8 g total fat). Absorption of EPA, but not of DHA, from fish oil triacylglycerols was significantly improved from 69% to 90% by co-ingestion with the high-fat meal. Absorption of both EPA and DHA from fish oil ethyl esters was increased three-fold, to about 60%, by co-ingestion with the high-fat meal, indicating that absorption of fatty acid ethyl esters is highly dependent on the amount of co-ingested fat.
authors.affiliation: Murdock Pharmaceuticals, Springville, Utah 84663.
authors.forename: L D
authors.initials: LD
authors.lastname: Lawson
authors.forename: B G
authors.initials: BG
authors.lastname: Hughes
mesh_terms: D000042:Absorption; D000328:Adult; D004041:Dietary Fats / Q000008:administration & dosage* / Q000494:pharmacology; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000378:metabolism*; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage / Q000378:metabolism*; D004952:Esters / Q000378:metabolism; D005395:Fish Oils / Q000378:metabolism*; D006801:Humans; D008049:Lipase / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000201:enzymology; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D004041:Dietary Fats; D004952:Esters; D005395:Fish Oils; D014280:Triglycerides; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid; D008049:Lipase