Relationship between cerebrospinal fluid somatostatin and peripheral thyroid hormones with carbamazepine treatment.
The relationship between CSF somatostatin and peripheral thyroid hormones was assessed in 11 affectively ill patients before and during carbamazepine treatment. A direct relationship between CSF somatostatin and plasma thyroxine and free thyroxine, but not triiodothyronine, was observed both while patients were medication-free and during carbamazepine treatment. These first data in man are consistent with those in animals, suggesting a close interrelationship between somatostatin and thyroid regulation.
Joffe
R T
RT
Rubinow
D R
DR
Post
R M
RM
Uhde
T W
TW
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D002220:Carbamazepine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013004:Somatostatin / Q000134:cerebrospinal fluid*; D013963:Thyroid Hormones / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D013963:Thyroid Hormones; D014284:Triiodothyronine; D002220:Carbamazepine; D013004:Somatostatin; D013974:Thyroxine