Specific antagonism by RO 15-1788 of benzodiazepine-induced increases in food intake in rhesus monkeys.
Food intake of rhesus monkeys was limited to a single daily 2 hr session of banana flavored pellet availability, seven days a week. Following stabilization of intake, the effects of intragastric bromazepam, diazepam and pentobarbital, when given alone, were determined by delivering a dose twice weekly, 60 min before the session. Dose-dependent increases in food intake were observed with the following descending order of potencies: bromazepam, diazepam and pentobarbital. RO 15-1788 (0.5-1.0 mg/kg, IM), when given alone, five min before the session had no effect on food intake. When given in combination with bromazepam and diazepam, RO 15-1788 completely blocked the increases in food intake observed when the benzodiazepines were given alone. The specificity of this antagonism was shown by the failure of RO 15-1788 to alter the food intake increases induced by pentobarbital. These results confirm and extend previous reports of the specific antagonism of benzodiazepine behavioral effects by RO 15-1788 to an additional species and another behavioral effect of benzodiazepines.
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D000818:Animals; D014151:Anti-Anxiety Agents / Q000037:antagonists & inhibitors*; D001570:Benzodiazepinones / Q000494:pharmacology*; D001960:Bromazepam / Q000494:pharmacology; D003292:Convulsants / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D005442:Flumazenil; D008253:Macaca mulatta; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D003292:Convulsants; D005442:Flumazenil; D010424:Pentobarbital; D003975:Diazepam; D001960:Bromazepam