Influence of thyroidectomy on brain catecholamines during the postnatal period.
The influence of early thyroidectomy (Tx) on changes in dopamine (DA) and noradrenaline (NA) during the postnatal period (30, 45 and 60 days old) was studied in the diencephalon and the rest of the brain of male and female rats. Thyroidectomy interfered with the normal growth of the animals, decreased brain weight and markedly influenced the developmental pattern of both DA and NA in the diencephalon. When compared with control values, the DA concentration, in 45- and 60-day-old Tx male rats, was 29 and 43% lower, respectively, and 21 and 43% lower, respectively, in Tx females. Diencephalic NA levels in Tx rats were also lower than those observed in controls, 15% inferior in 45- and 60-day-old males; 27 and 22% lower, respectively, in females. Thyroidectomy does not significantly alter the level of either amine in the rest of the brain.
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D000818:Animals; D001921:Brain / Q000254:growth & development; D001923:Brain Chemistry; D002395:Catecholamines / Q000378:metabolism*; D004027:Diencephalon / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005260:Female; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy; D013997:Time Factors
D002395:Catecholamines; D004298:Dopamine; D009638:Norepinephrine