Hormone-mediated inositol lipid breakdown in hepatocytes and WRK1 cells: relationship to receptor function.
All hormones and neurotransmitters which provoke their intracellular effects by increasing the cytosolic concentration of Ca2+ in their target cells also stimulate the breakdown of inositol phospholipids. Much evidence suggests that this breakdown is intimately involved in the mechanism which couples cell-surface receptor activation to intracellular Ca2+ mobilization. Recent results indicate that the primary, receptor-mediated event in stimulated cells is a phosphodiesteric hydrolysis of phosphatidylinositol 4,5-bisphosphate to yield inositol trisphosphate and diacylglycerol. It is likely that both products of this reaction fulfill 'second messenger' roles within stimulated cells.
Kirk
C J
CJ
Guillon
G
G
Balestre
M N
MN
Creba
J A
JA
Michell
R H
RH
Jard
S
S
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D005260:Female; D006728:Hormones / Q000502:physiology*; D008094:Lithium / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000502:physiology; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000378:metabolism*; D011945:Receptors, Angiotensin / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*; D017483:Receptors, Vasopressin; D014667:Vasopressins / Q000494:pharmacology
D006728:Hormones; D018377:Neurotransmitter Agents; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D011945:Receptors, Angiotensin; D011956:Receptors, Cell Surface; D017483:Receptors, Vasopressin; C037178:phosphatidylinositol 4-phosphate; D014667:Vasopressins; D008094:Lithium; D000109:Acetylcholine; D002118:Calcium