title: Effect of bacterial products on prostaglandin E production by amnion cells.
abstract: An in-vitro model was set up to study a possible causal relation between bacterial colonisation of extraplacental membranes and spontaneous preterm labour. When amnion cells in tissue culture were exposed to bacterial products, their prostaglandin E output rose considerably. The degree of response varied with the organism. These findings support the theory that bacterial products may be responsible for the premature onset of labour.
authors.forename: R F
authors.initials: RF
authors.lastname: Lamont
authors.forename: M
authors.initials: M
authors.lastname: Rose
authors.forename: M G
authors.initials: MG
authors.lastname: Elder
mesh_terms: D000650:Amnion / Q000166:cytology / Q000378:metabolism*; D001419:Bacteria / Q000302:isolation & purification / Q000378:metabolism*; D001441:Bacteroides fragilis / Q000302:isolation & purification / Q000378:metabolism; D046508:Culture Techniques; D015232:Dinoprostone; D013293:Enterococcus faecalis / Q000302:isolation & purification / Q000378:metabolism; D004926:Escherichia coli / Q000302:isolation & purification / Q000378:metabolism; D005260:Female; D006801:Humans; D007752:Obstetric Labor, Premature / Q000382:microbiology; D010741:Phospholipases A / Q000494:pharmacology; D011247:Pregnancy; D011458:Prostaglandins E / Q000096:biosynthesis*; D014590:Uterine Contraction; D014621:Vagina / Q000382:microbiology
chemical_list: D011458:Prostaglandins E; D010741:Phospholipases A; D015232:Dinoprostone