title: Epidermal-growth-factor receptors and oestrogen receptors in human breast cancer.
abstract: Competitive binding and monoclonal antibody staining techniques were used to demonstrate high-affinity (Kd = 1.9 nmol/l) receptors for epidermal growth factor (EGF) in 35 of 104 primary human breast tumours and in 10 of 14 secondary lymph-node deposits. There was a significant inverse relation between the presence of EGF receptors and the presence of oestrogen receptors in the primary tumours (p less than 0.01), and EGF receptors were found in a greater proportion of metastases than primary tumours (p less than 0.01). These results suggest that the presence of EGF receptors is associated with metastatic potential and that the growth of a proportion of poor-prognosis oestrogen-receptor-negative tumours may be regulated by peptide growth factors interacting with the EGF receptor.
authors.forename: J R
authors.initials: JR
authors.lastname: Sainsbury
authors.forename: J R
authors.initials: JR
authors.lastname: Farndon
authors.forename: G V
authors.initials: GV
authors.lastname: Sherbet
authors.forename: A L
authors.initials: AL
authors.lastname: Harris
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D066246:ErbB Receptors; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface; D011960:Receptors, Estrogen; D066246:ErbB Receptors