Vasoactive intestinal polypeptide-secreting ganglioneuromatosis affecting the entire colon and rectum.
This report describes a 7-year-old boy presenting with watery diarrhea, hypokalemia, and hypochlohydria associated with vasoactive intestinal polypeptide (VIP)-secreting ganglioneuromatosis involving the entire colon and rectum. The child's symptoms resolved following proctocolectomy, and the VIP levels returned to normal. Although 55 previous children have been reported with VIP-secreting tumors, this case is the first involving the entire colon and rectum.
Rescorla
F J
FJ
Department of Surgery, Indiana University School of Medicine, Indianapolis.
Vane
D W
DW
Fitzgerald
J F
JF
West
K W
KW
Grosfeld
J L
JL
D007516:Adenoma, Islet Cell / Q000209:etiology*; D002648:Child; D003110:Colonic Neoplasms / Q000378:metabolism*; D005729:Ganglioneuroma / Q000378:metabolism*; D006801:Humans; D008297:Male; D012004:Rectal Neoplasms / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*; D003969:Vipoma / Q000209:etiology*
D014660:Vasoactive Intestinal Peptide