title: Simulation of mechanical to neural transduction in the auditory receptor.
abstract: A probabilistic model is described for transmitter release from hair cells, auditory neuron EPSP's, and discharge patterns. The model assumes that the release fraction of the transmitter is a function of stimulus intensity. It further assumes that some of this transmitter substance is taken back into the cell while some is irretrievably lost from the cleft. These assumptions differ from other recent models which propose multiple release sites, fixed release fractions, and no transmitter reuptake. The model produces realistic mammalian rate intensity functions, interval and period histograms, incremental responses, and adaptation effects. It mimics successfully the adaptation of successive EPSP amplitudes of the afferent neuron of the goldfish sacculus and offers a reinterpretation of the implications of these studies for hair cell synaptic mechanism.
authors.forename: R
authors.initials: R
authors.lastname: Meddis
mesh_terms: D000818:Animals; D001306:Auditory Pathways / Q000502:physiology; D001307:Auditory Perception / Q000502:physiology*; D002463:Cell Membrane Permeability; D003201:Computers; D005072:Evoked Potentials, Auditory; D006198:Hair Cells, Auditory / Q000502:physiology*; D006801:Humans; D008144:Loudness Perception / Q000502:physiology; D008959:Models, Neurological; D009412:Nerve Fibers / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology; D010898:Pitch Perception / Q000502:physiology; D012032:Refractory Period, Electrophysiological; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission; D000159:Vestibulocochlear Nerve / Q000502:physiology*
chemical_list: D018377:Neurotransmitter Agents