title: Felodipine can replace minoxidil in the treatment of refractory hypertension.
abstract: In a group of 15 men with severe hypertension in a double-blind crossover trial, the new calcium antagonist felodipine has been shown to lower blood pressure as effectively as minoxidil when used in combination with a beta-blocker and a loop diuretic. Felodipine was well tolerated and may have a role in the management of severe hypertension.
authors.affiliation: Department of Medicine, Royal Infirmary, Edinburgh, Scotland, UK.
authors.forename: D
authors.initials: D
authors.lastname: MacLeod
authors.forename: C G
authors.initials: CG
authors.lastname: Wathen
authors.forename: L
authors.initials: L
authors.lastname: Tucker
authors.forename: E A
authors.initials: EA
authors.lastname: Forret
authors.forename: T W
authors.initials: TW
authors.lastname: Hill
authors.forename: A L
authors.initials: AL
authors.lastname: Muir
mesh_terms: D000368:Aged; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D015736:Felodipine / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008914:Minoxidil / Q000627:therapeutic use*
chemical_list: D008914:Minoxidil; D015736:Felodipine