[Dependence of the antiviral activity of the poly(G).poly(C) complex on the size of the continuous poly(C)segments].
Modification of poly(C) by various frequency treatment with adenosine non-complementary to guanosine has produced poly(G) X poly (C.A) complexes with continuous double-stranded areas the length of which is determined by C/A ratio. Studies of the antiviral activity of poly(G).poly(C,A) complexes with C/A from 10:1 to 90:1 and poly(G).poly(C) in vesicular stomatitis virus-infected chick embryo cell cultures and in experimental tick-borne encephalitis of mice demonstrated that the maximum activity is achieved at an average lengths of double-stranded areas of 90 nucleotide pairs. At the same time, a low but statistically significant antiviral activity is observed at a length of double-stranded areas of 10-30 nucleotide pairs.
Vil'ner
L M
LM
Kogan
E M
EM
Naumovich
N G
NG
Sidorova
N S
NS
Glazunov
E A
EA
D000818:Animals; D000998:Antiviral Agents; D001482:Base Composition; D002642:Chick Embryo; D004353:Drug Evaluation, Preclinical; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy; D006868:Hydrolysis; D051379:Mice; D008807:Mice, Inbred BALB C; D011066:Poly C / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D011068:Poly G / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D011131:Polyribonucleotides / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D000998:Antiviral Agents; D011131:Polyribonucleotides; D011068:Poly G; C008961:poly G-poly C; D011066:Poly C
Zavisimost' protivovirusnoĭ aktivnosti kompleksa poli(G).poli(Ts) ot razmera nepreryvnykh uchastkov poli(Ts).