The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice.
When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.
Vogel
J
J
Laboratory of Molecular Virology, National Cancer Institute, Bethesda, Maryland 20892.
Hinrichs
S H
SH
Reynolds
R K
RK
Luciw
P A
PA
Jay
G
G
D000818:Animals; D001483:Base Sequence; D002455:Cell Division; D015696:Gene Products, tat; D006678:HIV / Q000235:genetics*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000378:metabolism; D012514:Sarcoma, Kaposi / Q000235:genetics* / Q000473:pathology; D012867:Skin / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology; D014157:Transcription Factors / Q000378:metabolism; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D012333:RNA, Messenger; D014157:Transcription Factors; D054322:tat Gene Products, Human Immunodeficiency Virus