Barrett's oesophagus.
The bulk of available evidence supports the view that Barrett's oesophagus is an acquired condition due to chronic gastro-oesophageal reflux. It is possible that a few cases are congenital. Barrett's oesophagus gives rise to severe stricture and ulceration and has a significant malignant potential. Treatment is designed to prevent reflux and, if possible, to reverse the metaplastic change. Dysplasia is of ominous significance and requires frequent careful surveillance.
Hennessy
T P
TP
D000230:Adenocarcinoma / Q000150:complications; D000293:Adolescent; D000328:Adult; D001471:Barrett Esophagus / Q000150:complications / Q000473:pathology / Q000628:therapy*; D002927:Cimetidine / Q000627:therapeutic use; D004848:Epithelium / Q000473:pathology; D004935:Esophageal Diseases / Q000628:therapy*; D004938:Esophageal Neoplasms / Q000150:complications; D004942:Esophagitis, Peptic / Q000150:complications; D004947:Esophagus / Q000473:pathology; D005769:Gastrointestinal Motility; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male
D006635:Histamine H2 Antagonists; D002927:Cimetidine