title: Vecuronium induced neuromuscular blockade. The effect of increasing dose on speed of onset.
abstract: The speed of onset of neuromuscular blockade was measured for increasing doses of vecuronium. Onset times were found to be shorter with larger doses, up to a limit of ED95 X 3 (0.15 mg/kg). Thereafter, increasing the dose, even up to ED95 X 8 (0.4 mg/kg), did not appreciably shorten the time to full neuromuscular blockade. The clinical implications of, and pharmacokinetic basis for, these findings are discussed.
authors.forename: W R
authors.initials: WR
authors.lastname: Casson
authors.forename: R M
authors.initials: RM
authors.lastname: Jones
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D013997:Time Factors; D014673:Vecuronium Bromide
chemical_list: D009466:Neuromuscular Blocking Agents; D014673:Vecuronium Bromide; D010197:Pancuronium