Neuropeptides in human cerebrospinal fluid.
Ten neuropeptides were measured by RIA in human cerebrospinal fluid obtained from 30 normal volunteers. The levels of seven peptides (corticotropin releasing factor, adrenocorticotropin, vasoactive intestinal peptide, somatostatin, beta-endorphin, beta-lipotropin, and the N-terminal fragment of proopiomelanocortin) were highly, positively correlated with one another. This result is consistent with the hypothesis that cerebrospinal fluid levels of these seven peptides are a function of some common regulatory factor, such as shared release into the cerebrospinal fluid.
Berrettini
W H
WH
Nurnberger
J I
JI
Gold
P W
PW
Chretien
M
M
Chrousos
G P
GP
Chan
J S
JS
Goldin
L R
LR
Gershon
E S
ES
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000134:cerebrospinal fluid; D000328:Adult; D003346:Corticotropin-Releasing Hormone / Q000134:cerebrospinal fluid; D004723:Endorphins / Q000134:cerebrospinal fluid; D006801:Humans; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000134:cerebrospinal fluid*; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D011333:Pro-Opiomelanocortin / Q000134:cerebrospinal fluid; D013004:Somatostatin / Q000134:cerebrospinal fluid; D014660:Vasoactive Intestinal Peptide / Q000134:cerebrospinal fluid; D001615:beta-Endorphin; D008083:beta-Lipotropin / Q000134:cerebrospinal fluid
D004723:Endorphins; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D001615:beta-Endorphin; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D008083:beta-Lipotropin