title: Calcium channel blockade: central hemodynamic effects.
abstract: Despite differences in vasodilatation, inotropy and chronotropy between verapamil, nifedipine and diltiazem when tested in vitro, these drugs will produce similar central hemodynamic effects in healthy young or middle-aged individuals, provided they are given in equipotent doses. The individual profiles of hemodynamic action of these calcium channel blockers are briefly reviewed and discussed.
authors.forename: L G
authors.initials: LG
authors.lastname: Ekelund
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D004110:Diltiazem / Q000494:pharmacology; D004347:Drug Interactions; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
chemical_list: D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine