title: Effect of vitamin E and other amelioratory agents on the fenvalerate-mediated skin sensation.
abstract: Previous investigations have demonstrated that dermal exposure to fenvalerate or other synthetic pyrethroid insecticides can produce a skin sensory response characterized by an itching/tingling sensation in humans and animals. The objective of this investigation performed in guinea pigs was to establish treatments which would be effective against pyrethroid-mediated skin sensation. Two classes of agents were tested. Barrier agents, which block penetration of substances through the skin, did not significantly reduce the fenvalerate-mediated skin sensations. Post-treatments with steroidal Dermolate, antihistamine Delamine or anti-inflammatory aspirin did not significantly reduce the pyrethroid-mediated skin sensation. However, Bicozene (a local anesthetic cream) and Tashan (a vitamin A, D, and E-containing cream) were effective in reducing the pyrethroid-mediated skin sensations. Prior (30 min and 5h) dermal application of vitamin E was found to be effective in significantly reducing the fenvalerate-mediated skin sensation; even when applied 29 h prior to fenvalerate exposure, there appeared to be a reduced skin response. Piperonyl butoxide (PBO), a pesticide synergist, reduced the fenvalerate skin sensations when applied either directly to the skin or in conjunction with the pyrethroid.
authors.forename: L A
authors.initials: LA
authors.lastname: Malley
authors.forename: S Z
authors.initials: SZ
authors.lastname: Cagen
authors.forename: C M
authors.initials: CM
authors.lastname: Parker
authors.forename: T H
authors.initials: TH
authors.lastname: Gardiner
authors.forename: G A
authors.initials: GA
authors.lastname: van Gelder
authors.forename: G P
authors.initials: GP
authors.lastname: Rose
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009570:Nitriles; D011722:Pyrethrins / Q000633:toxicity*; D012867:Skin / Q000187:drug effects / Q000473:pathology*; D014810:Vitamin E / Q000494:pharmacology*; D014815:Vitamins / Q000494:pharmacology
chemical_list: D000779:Anesthetics, Local; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D006634:Histamine H1 Antagonists; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D014815:Vitamins; D014810:Vitamin E; C017690:fenvalerate