Urinary gamma-glutamyl transpeptidase activity in dogs with gentamicin-induced nephrotoxicity.
Serum creatinine concentrations, 24-hour endogenous creatinine clearance, and 24-hour urinary gamma-glutamyl transpeptidase (UGGT) activity were measured daily in 6 dogs given nephrotoxic dosages of gentamicin (10 mg/kg of body weight) every 8 hours for 10 days. Mean UGGT activity was significantly increased by day 5 (P less than 0.05) and preceded significant increases in serum creatinine values (greater than 2.0 mg/dl) observed on day 9. Endogenous creatinine clearance remained within normal limits (2.98 +/- 0.96 ml/min/kg) until day 8. Urinalyses performed 8 days after initiation of gentamicin treatment indicated renal tubular damage (granular casts) in 1 of the 6 dogs, and glucosuria in 3 of the 6 dogs. Measurement of UGGT activity was a more sensitive and reliable method of assessing acute renal tubular damage induced by gentamicin than were serum creatinine concentrations or 24-hour endogenous creatinine clearance.
Greco
D S
DS
Turnwald
G H
GH
Adams
R
R
Gossett
K A
KA
Kearney
M
M
Casey
H
H
D000818:Animals; D003404:Creatinine / Q000097:blood / Q000378:metabolism; D004283:Dog Diseases / Q000139:chemically induced* / Q000201:enzymology; D004285:Dogs; D005260:Female; D005839:Gentamicins / Q000633:toxicity*; D007674:Kidney Diseases / Q000139:chemically induced / Q000201:enzymology / Q000662:veterinary*; D008297:Male; D005723:gamma-Glutamyltransferase / Q000652:urine*
D005839:Gentamicins; D003404:Creatinine; D005723:gamma-Glutamyltransferase