Rapid diagnostic test for ocular adenovirus.
A new, direct, enzyme immunoassay test (Adenoclone, Cambridge BioScience, Hopkinton, MA) was evaluated for the rapid diagnosis of ocular adenovirus infections. In 36 culture-proven cases of adenovirus ocular infection, direct Adenoclone testing of conjunctival swabs was positive in 24 of 31 patients (77%) tested within 1 week of onset of symptoms, and in one of five patients (20%) who presented after 1 week (P less than 0.02). Overall sensitivity was 69%, whereas specificity was 100%. The authors conclude that a positive Adenoclone test is reliable in the rapid diagnosis of early adenovirus ocular infections.
Wiley
L
L
Charles T. Campbell Microbiological Laboratory, Department of Ophthalmology, University of Pittsburgh, PA 15213.
Springer
D
D
Kowalski
R P
RP
Arffa
R
R
Roat
M I
MI
Thoft
R A
RA
Gordon
Y J
YJ
D000257:Adenoviridae Infections / Q000175:diagnosis*; D000258:Adenovirus Infections, Human / Q000175:diagnosis*; D005069:Evaluation Studies as Topic; D005128:Eye Diseases / Q000175:diagnosis*; D006801:Humans; D011933:Reagent Kits, Diagnostic / Q000592:standards; D012189:Retrospective Studies; D013997:Time Factors
D011933:Reagent Kits, Diagnostic