Hematopoiesis on cellulose ester membranes (CEM). VIII. Studies of the hematopoietic microenvironment developing on intraperitoneally implanted CEM in S1/S1d and S1+/S1+ mice.
Cellulose ester membranes (CEM) were implanted intraperitoneally into S1/S1d and S1+/ S1+ mice. These CEM rapidly became coated with peritoneal cells capable of supporting primarily granulocytic colony development after seven days. S1/S1d-coated CEM showed a diminished capacity to support colony development compared with S1+/ S1+ CEM, perhaps reflecting the defect in the hematopoietic microenvironment of these mice. Marrow cells from S1+/S1+ and S1/S1d mice generated similar numbers of colonies on S1+/S1+ CEM. When CEM were transferred from a primary to a secondary host there was a tendency to remodel the CEM toward the characteristics of the secondary host. Peritoneal cells coating CEM from S1/S1d mice had less phagocytosis of yeast particles than peritoneal cells from S1+/S1+ mice. The cell coat on the membranes from S1/S1d mice was fewer cell layers in thickness than those on membranes coated in S1+/ S1+ mice.
Knospe
W H
WH
Husseini
S G
SG
Adler
S S
SS
D000748:Anemia, Macrocytic / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D002482:Cellulose / Q000031:analogs & derivatives*; D005260:Female; D006098:Granulocytes / Q000473:pathology*; D006410:Hematopoiesis / Q000528:radiation effects; D018380:Hematopoietic Stem Cell Transplantation; D008264:Macrophages / Q000502:physiology; D008567:Membranes, Artificial; D051379:Mice; D010587:Phagocytosis
D008567:Membranes, Artificial; C020253:cellulose ester plastic; D002482:Cellulose