Residual effects of zopiclone and benzodiazepine hypnotics on psychomotor performance related to car driving.
A double-blind, randomized, cross-over study was carried out in 10 normal healthy volunteers to investigate the residual effects of 7.5 mg zopiclone, 1 mg lormetazepam, 0.25 mg triazolam, 1 mg flunitrazepam and placebo. Tests of psychomotor performance and analogues of car driving ability were administered the morning following night-time medication. Changes with respect to placebo in an information-processing task one hour after taking the medications confirmed the hypnotic efficacy of zopiclone, triazolam and flunitrazepam. Flunitrazepam also produced a significant depression of the Critical Flicker Fusion Threshold (CFF) and increased subjective ratings of sedation one hour after nocturnal dosing. Flunitrazepam impaired the reaction time on the information-processing test the morning following doses of 1 mg.
Harrison
C
C
Subhan
Z
Z
Hindmarch
I
I
D000328:Adult; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D001334:Automobile Driving; D053961:Azabicyclo Compounds; D001569:Benzodiazepines; D004311:Double-Blind Method; D005260:Female; D005425:Flicker Fusion / Q000187:drug effects; D006801:Humans; D010879:Piperazines / Q000009:adverse effects*; D011597:Psychomotor Performance / Q000187:drug effects*; D011897:Random Allocation; D011930:Reaction Time / Q000187:drug effects; D012890:Sleep / Q000187:drug effects
D014151:Anti-Anxiety Agents; D053961:Azabicyclo Compounds; D010879:Piperazines; C515050:zopiclone; D001569:Benzodiazepines