Multiple forms of somatostatin-like immunoreactivity are not influenced by cholinergic denervation of rat hippocampus.
Hippocampal choline acetyltransferase was reduced by 89% in rats two weeks after electrolytic lesion of the septum. The hippocampal concentrations of somatostatin (SOM)-14, SOM-28 and high-molecular-weight SOM were unaltered, suggesting that the activity of hippocampal SOM neurones is not influenced by cholinergic afferents. The relevance of this finding to Alzheimer-type dementia and Down's syndrome is discussed.
Pierotti
A R
AR
Simpson
J
J
D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003714:Denervation; D004314:Down Syndrome / Q000378:metabolism; D006624:Hippocampus / Q000201:enzymology / Q000276:immunology* / Q000502:physiology; D008297:Male; D010275:Parasympathetic Nervous System / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000276:immunology* / Q000378:metabolism
D013004:Somatostatin; D002795:Choline O-Acetyltransferase