Azathioprine and cyclosporin: different tissue matching criteria needed?
Of 275 renal transplants performed over seven years in a single unit, azathioprine was the main immunosuppressive agent in 128 and cyclosporin in 147. With azathioprine graft survival was, as expected, negatively related to the number of HLA mismatches; with cyclosporin the reverse held true.
Harris
K R
KR
Digard
N
N
Gosling
D C
DC
Tate
D G
DG
Campbell
M J
MJ
Gardner
B
B
Sharman
V L
VL
Slapak
M
M
D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use*; D002648:Child; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D006085:Graft Survival / Q000187:drug effects; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D011239:Prednisolone; D001379:Azathioprine