[Pharmacodynamics of etilfrine pivilate in the orthostatic syndrome].
Etilefrine pivalate is synthesized by esterification of etilefrine with pivalic acid anhydride. The pharmacodynamics were investigated in 8 subjects suffering from the orthostatic syndrome. Cardiocirculatory parameters were measured in the lying and standing position for 3 h after the oral ingestion of 30 mg of etilefrine pivalate. In the supine position only minor effects on the blood pressure were seen. In three subjects with true orthostatic syndrome the systolic blood pressure was increased from 10 to 60 min after medication. Up to 30 min positive inotropic effects were seen. During 70 degree tilt etilefrine pivalate could stabilize the blood pressure 20 min after medication, the pathological increase in heart rate was reduced. In non-orthostatic patients positive inotropic effects were seen in the lying position only. Blood pressure and heart rate were not influenced in the supine position.
Hengstmann
J H
JH
Brecht
T
T
Ewers
W
W
D001794:Blood Pressure / Q000187:drug effects; D005039:Etilefrine / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007024:Hypotension, Orthostatic / Q000188:drug therapy* / Q000503:physiopathology; D009200:Myocardial Contraction / Q000187:drug effects; D010656:Phenylephrine / Q000031:analogs & derivatives*; D011187:Posture; D013997:Time Factors
D010656:Phenylephrine; C046842:etilefrine pivalate; D005039:Etilefrine
Pharmakodynamik von Etilefrinpivalat beim Orthostasesyndrom.