title: HLA-DQ beta-chain polymorphism linked to myasthenia gravis.
abstract: The HLA-DR3 haplotype is associated with increased risk of myasthenia gravis (MG) and a number of other autoimmune diseases, including insulin-dependent diabetes mellitus (IDDM), coeliac disease, and premature ovarian failure (POF). With a cDNA probe for a DQ beta gene, a 15 kb Hinc II restriction fragment has been demonstrated in genomic DNA from 7 of 16 HLA-DR3 patients with MG, 1 of 19 healthy DR3 controls, and none of 24 DR3 patients with IDDM, coeliac disease, or POF. The HLA-DQ polymorphism may be closely linked to a genetic locus regulating immune responsiveness to acetylcholine receptor and susceptibility to MG.
authors.forename: J
authors.initials: J
authors.lastname: Bell
authors.forename: L
authors.initials: L
authors.lastname: Rassenti
authors.forename: S
authors.initials: S
authors.lastname: Smoot
authors.forename: K
authors.initials: K
authors.lastname: Smith
authors.forename: C
authors.initials: C
authors.lastname: Newby
authors.forename: R
authors.initials: R
authors.lastname: Hohlfeld
authors.forename: K
authors.initials: K
authors.lastname: Toyka
authors.forename: H
authors.initials: H
authors.lastname: McDevitt
authors.forename: L
authors.initials: L
authors.lastname: Steinman
mesh_terms: D002446:Celiac Disease / Q000235:genetics; D004262:DNA Restriction Enzymes; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D005260:Female; D006580:Genetic Carrier Screening; D005819:Genetic Markers; D006683:HLA-DQ Antigens; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D006824:Hybridization, Genetic; D009157:Myasthenia Gravis / Q000235:genetics*; D010049:Ovarian Diseases / Q000235:genetics; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers; D006683:HLA-DQ Antigens; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II; D004262:DNA Restriction Enzymes