The antibacterial effect of selected neuroleptics on Vibrio cholerae.
The present investigation has been undertaken to illustrate the anti-bacterial effect of chlorpromazine, clopenthixol and levomepromazine-maleate. It has been shown that clopenthixol has the strongest antibacterial effect. It is known that chlorpromazine also has an antisecretory activity. The fact that clopenthixol exists in cis(Z)- and trans(E)-isomerical compounds, and that these compounds both have an antibacterial effect, but only the cis-compound has an antisecretory and neuroleptic effect, might suggest the development of more specific pharmaceuticals in these new fields.
Kristiansen
J E
JE
Gaarslev
K
K
D014150:Antipsychotic Agents / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D003006:Clopenthixol / Q000494:pharmacology; D008728:Methotrimeprazine / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D014734:Vibrio cholerae / Q000187:drug effects*
D014150:Antipsychotic Agents; D003006:Clopenthixol; D008728:Methotrimeprazine; D002746:Chlorpromazine