title: Combination alprazolam-neuroleptic treatment of the positive and negative symptoms of schizophrenia.
abstract: Alprazolam, when added under double-blind conditions to a stable neuroleptic regimen in two patients with schizophrenia, resulted in clinically apparent improvement in positive and negative schizophrenic symptoms. Both patients showed significant worsening of symptoms following reduction or discontinuation of alprazolam.
authors.forename: O M
authors.initials: OM
authors.lastname: Wolkowitz
authors.forename: D
authors.initials: D
authors.lastname: Pickar
authors.forename: A R
authors.initials: AR
authors.lastname: Doran
authors.forename: A
authors.initials: A
authors.lastname: Breier
authors.forename: J
authors.initials: J
authors.lastname: Tarell
authors.forename: S M
authors.initials: SM
authors.lastname: Paul
mesh_terms: D000328:Adult; D000525:Alprazolam; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001569:Benzodiazepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005476:Fluphenazine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology
chemical_list: D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D001569:Benzodiazepines; D005476:Fluphenazine; D000525:Alprazolam