Multiphase extraction: rapid phase-transfer of [18F]fluoride ion for nucleophilic radiolabeling reactions.
In multiphase extraction [18F]fluoride ion for radiolabeling is recovered from target water by passage through a small column of microporous polymer impregnated with a lipophilic cryptand or quaternary ammonium salt. The 18O enriched water can be recovered for reuse. The [18F]fluoride ion-pair is eluted from the column by a small volume of acetonitrile or other organic solvent. Evaporation of the acetonitrile removes traces of water to yield a reactive ion pair for nucleophilic radiofluorination reactions. A wide range of ion-pairs based on K+ or NH+4 cryptands or quaternary ammonium salts can be employed. The method was applied to the synthesis of [18F]FDG.
Jewett
D M
DM
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109-0552.
Toorongian
S A
SA
Mulholland
G K
GK
Watkins
G L
GL
Kilbourn
M R
MR
D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000138:chemical synthesis; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D007553:Isotope Labeling / Q000379:methods*
D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose