title: Dopamine receptor agonistic activities of R- and S-enantiomers of 4-hydroxy-2-di-n-propylaminoindan in cat hearts.
abstract: In-vitro and in-vivo studies were used to evaluate the presynaptic dopamine receptor stimulating activities of R- and S-enantiomers of 4-hydroxy-2-di-n-propylaminoindan in cat hearts. Bioassay results show that the R-enantiomer is 100 times more potent than the S-enantiomer in both in-vitro and in-vivo preparations.
authors.forename: M
authors.initials: M
authors.lastname: Ilhan
authors.forename: J R
authors.initials: JR
authors.lastname: Flynn
authors.forename: J P
authors.initials: JP
authors.lastname: Long
authors.forename: R K
authors.initials: RK
authors.lastname: Bhatnagar
authors.forename: J G
authors.initials: JG
authors.lastname: Cannon
mesh_terms: D000818:Animals; D002415:Cats; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007189:Indans / Q000494:pharmacology*; D007192:Indenes / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000187:drug effects*; D013237:Stereoisomerism
chemical_list: D007189:Indans; D007192:Indenes; D011954:Receptors, Dopamine; C044899:4-hydroxy-2-(di-n-propylamino)indan