title: Dopamine modulates neuronal activities related to motor performance in the monkey prefrontal cortex.
abstract: Effects of iontophoretically applied dopamine were investigated in prefrontal neurons of the monkey which showed activity changes during a visual reaction time task. The task consisted of an initial waiting phase (3.0 s), a warning phase (green lamp, 1.5-3.5 s), a lever-release GO phase (red lamp) and a reward phase. The neurons (n = 99) showed their activity changes during the warming (n = 31), GO (n = 43) or reward (n = 25) phase. Among those, dopamine predominantly influenced the GO phase-related activities (39/43) and the activity changes were enhanced by dopamine. Further, fluphenazine attenuated the GO phase-related activity changes. Results suggest that prefrontal dopamine may be involved in modulations of neuronal activities related to motor performance.
authors.forename: T
authors.initials: T
authors.lastname: Sawaguchi
authors.forename: M
authors.initials: M
authors.lastname: Matsumura
authors.forename: K
authors.initials: K
authors.lastname: Kubota
mesh_terms: D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D005074:Evoked Potentials, Visual / Q000187:drug effects; D005476:Fluphenazine / Q000494:pharmacology; D005625:Frontal Lobe / Q000187:drug effects* / Q000502:physiology; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D007478:Iontophoresis; D008253:Macaca mulatta; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D013238:Stereotaxic Techniques
chemical_list: D005971:Glutamates; D018698:Glutamic Acid; D005476:Fluphenazine; D004298:Dopamine