A selective potentiation by naloxone of L-dopa but not atropine suppression of oxotremorine-induced tremor in mice.
Oxotremorine-induced tremor activity in mice was suppressed by pretreatment with either L-dopa or atropine. Additional pretreatment with the opiate receptor blocker naloxone significantly potentiated the antitremor effect of L-dopa but not that of atropine. These findings indicate a selectivity of drug interaction between naloxone and L-dopa.
Quock
R M
RM
Lucas
T S
TS
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D004357:Drug Synergism; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009270:Naloxone / Q000494:pharmacology*; D010095:Oxotremorine / Q000037:antagonists & inhibitors*; D013997:Time Factors; D014202:Tremor / Q000139:chemically induced / Q000503:physiopathology*
D009270:Naloxone; D007980:Levodopa; D010095:Oxotremorine; D001285:Atropine