Exercise training during chronic beta blockade in cardiovascular disease.
To determine whether cardioselective and nonselective beta-blocking agents impair exercise training effects in patients with cardiovascular disease, 50 subjects were evaluated. All were in a 3-times-weekly medically supervised outpatient exercise program for 3 months or longer. Treadmill exercise tests were done initially and at 3-month intervals. Eight patients were receiving atenolol, 23 propranolol, 3 timolol, 6 metoprolol, and 8 nadolol and 1 patient receiving timolol changed to atenolol and 1 receiving nadolol changed to propranolol. Treadmill test duration increased significantly (p less than 0.05), from 7.5 +/- 2.5 to 9.9 +/- 2.3 minutes, with exercise training. In 35 of the 50 subjects heart rate at rest decreased significantly (p less than 0.05) from 67.5 +/- 11.7 to 60.4 +/- 10.5 beats/min. The other 15 subjects were excluded from heart rate analysis because beta blockade was begun 1 to 2 weeks after the initial exercise test. It is concluded that exercise training effects (increase in exercise test duration and decrease in resting heart rate) can be achieved in patients with cardiovascular disease in the presence of both cardioselective and nonselective beta-blocking agents.
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D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use; D001026:Coronary Artery Bypass; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology / Q000534:rehabilitation / Q000601:surgery; D009248:Nadolol; D005082:Physical Exertion; D011412:Propanolamines / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D013999:Timolol / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D009248:Nadolol; D001262:Atenolol; D013999:Timolol; D011433:Propranolol; D008790:Metoprolol