Late-onset adrenal hyperplasia in north Indian hirsute women.
The occurrence of late-onset congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency was studied in 60 consecutive hirsute women by means of adrenocorticotrophin (ACTH)-stimulated serum 17-hydroxyprogesterone (17-OHP) levels. Five (8.3%) women had an exaggerated response (ACTH-stimulated 17-OHP 3,160 +/- 560 ng/dl). All of them had regular periods and 3 were virilized. The other 2 were indistinguishable from those with idiopathic hirsutism or polycystic ovarian disease.
Mithal
A
A
Department of Endocrinology and Metabolism, All-India Institute of Medical Sciences, New Delhi.
Ammini
A C
AC
Godbole
M M
MM
Khurana
M L
ML
Raj
D
D
Karmarkar
M G
MG
Ahuja
M M
MM
D019326:17-alpha-Hydroxyprogesterone; D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000328:Adult; D005260:Female; D006628:Hirsutism / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D006908:Hydroxyprogesterones / Q000097:blood*; D007194:India
D006908:Hydroxyprogesterones; D019326:17-alpha-Hydroxyprogesterone; D000324:Adrenocorticotropic Hormone