[Protective effect of adrenergic alpha 2-receptor agonists in hypoxic hypoxia].
The antihypoxic effect of alpha 2-adrenoceptor agonists was studied by two different approaches: reproduction of the effect by a number of alpha 2-agonists and its blockade with selective antagonists. The data obtained suggest that alpha 2-adrenoceptor agonists increase the survival and the lifespan of mice in all the models of acute hypoxic hypoxia under study. A close correlation between antihypoxic action of alpha 2-adrenoceptor agonists and their anticalorigenic effect was established (r = +0.87; P less than 0.01).
Kulinskiĭ
V I
VI
Ol'khovskiĭ
I A
IA
Kovalevskiĭ
A N
AN
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D005260:Female; D000860:Hypoxia / Q000503:physiopathology / Q000517:prevention & control*; D051379:Mice; D010101:Oxygen Consumption / Q000187:drug effects; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*
D000316:Adrenergic alpha-Agonists; D011942:Receptors, Adrenergic, alpha
Zashchitnoe deĭstvie agonistov alpha 2-adrenoretseptorov pri gipoksicheskoĭ gipoksii.