title: The immunobiology and immunopharmacology of the allergic response.
abstract: Classic allergic reactions of the immediate type are IgE dependent. These reactions are associated with a complex orchestration of genetic predisposition, allergen exposure patterns, allergen processing by mononuclear macrophages, helper and suppressor immunocytes, pharmacologically active inflammatory mediators, early and late-phase reactions, neurotransmitters, autonomic nervous system participation, intracellular cyclic nucleotide equilibrium, cellular and molecular activity, and a genetically predetermined end-organ hypersensitivity to a variety of specific and nonspecific excitants.
authors.forename: R G
authors.initials: RG
authors.lastname: Fadal
mesh_terms: D001341:Autonomic Nervous System / Q000503:physiopathology; D001402:B-Lymphocytes / Q000276:immunology; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D011935:Reagins / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D011935:Reagins; D007073:Immunoglobulin E; D000242:Cyclic AMP; D006152:Cyclic GMP