A new hemoglobin variant, Hb Mito [beta 144(HC 1) Lys----Glu], with increased oxygen affinity.
A new abnormal hemoglobin, Hb Mito [beta 144(HC 1) Lys----Glu], with an amino acid substitution in the 2,3-DPG pocket, was discovered in a Japanese female. This hemoglobin showed increased oxygen affinity, and decreased organic phosphate and Bohr effects, while the Hill constant n was normal.
Harano
K
K
Harano
T
T
Ueda
S
S
Ohkushi
T
T
Imai
K
K
D000595:Amino Acid Sequence; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D005971:Glutamates; D018698:Glutamic Acid; D006455:Hemoglobins, Abnormal / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006973:Hypertension / Q000097:blood; D007525:Isoelectric Focusing; D007564:Japan; D008239:Lysine; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*
D005971:Glutamates; D006455:Hemoglobins, Abnormal; C049112:hemoglobin Mito; D018698:Glutamic Acid; D008239:Lysine; D010100:Oxygen