Epstein-Barr virus (EBV)-associated undifferentiated carcinoma of the parotid gland.
A case of undifferentiated carcinoma of the salivary gland occurring in the parotid gland of a southern Chinese was reported. Tumour cells showed immunofluorescence for Epstein-Barr virus (EBV)-associated nuclear antigen, and DNA hybridization demonstrated the presence of EBV-DNA in tumour tissue. The findings in this case, together with previous reports, suggest a causal relationship between EBV and salivary gland carcinoma. The relationships between EBV and undifferentiated epithelial tumours of the salivary glands, nasopharynx and thymus are also discussed.
Huang
D P
DP
Department of Morbid Anatomy, Chinese University of Hong Kong.
Ng
H K
HK
Ho
Y H
YH
Chan
K M
KM
D000328:Adult; D002277:Carcinoma / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D004279:DNA, Viral / Q000032:analysis; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009693:Nucleic Acid Hybridization; D010307:Parotid Neoplasms / Q000276:immunology / Q000382:microbiology / Q000473:pathology*
D004279:DNA, Viral