Apomorphine injection stimulates beta-endorphin, adrenocorticotropin, and cortisol release in healthy man.
The effect of single injections of a dopaminergic agonist, apomorphine, on pituitary-adrenocortical function was investigated in healthy adult men by the measurement of plasma ACTH, beta-endorphin, cortisol and GH immunoreactivities. Single, subcutaneous injection of a subemetic dose of apomorphine (0.75 mg) resulted in a pronounced increase in plasma concentrations of GH, as well as ACTH, beta-endorphin, and cortisol, without induction of any serious adverse drug effects. These findings were confirmed in two separate experiments.
Jezova
D
D
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Vigas
M
M
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D001058:Apomorphine / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007279:Injections, Subcutaneous; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects; D001615:beta-Endorphin / Q000097:blood*
D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D001058:Apomorphine; D006854:Hydrocortisone