title: Inhibition of GABA uptake potentiates the effects of exogenous GABA on locust skeletal muscle.
abstract: Insect skeletal muscle is relatively insensitive to applied GABA, responses are elicited only when relatively high concentrations of GABA are used (greater than 10(-6) M). Pretreatment of the muscle with the GABA uptake inhibitors nipecotic acid, beta-aminobutyric acid or beta-alanine increases the sensitivity of the muscle to GABA by as much as 1000-fold. The evidence suggests the existence of a GABA uptake mechanism in the insect neuromuscular system which could reside in glial cells.
authors.forename: D
authors.initials: D
authors.lastname: Shepherd
authors.forename: N M
authors.initials: NM
authors.lastname: Tyrer
mesh_terms: D000613:Aminobutyrates / Q000494:pharmacology; D000818:Animals; D005260:Female; D018756:GABA Antagonists; D006110:Grasshoppers; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000502:physiology*; D009557:Nipecotic Acids / Q000494:pharmacology; D011392:Proline / Q000031:analogs & derivatives*; D015091:beta-Alanine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000613:Aminobutyrates; D018756:GABA Antagonists; D009557:Nipecotic Acids; D015091:beta-Alanine; C030278:nipecotic acid; C047667:3-aminobutyric acid; D005680:gamma-Aminobutyric Acid; D011392:Proline; C010983:homoproline