Imipramine binding in depressive patients diagnosed according to different criteria.
3H-imipramine binding to platelet membranes, Bmax and KD, was measured in depressed patients, who were divided into endogenous and non-endogenous depression according to three different criteria, the ICD-9, the Newcastle I and the Newcastle II rating scales. Two groups served as controls, a group of healthy volunteers and a group of psychiatric patients suffering from schizophrenia or senile dementia. No significant differences were found in either Bmax or in KD among the different groups of patients and the control groups.
Plenge
P
P
Psychochemistry Institute, Rigshospitalet, Copenhagen, Denmark.
Mellerup
E T
ET
Gjerris
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics*; D008297:Male; D008370:Manuals as Topic; D008875:Middle Aged; D011581:Psychological Tests; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D007099:Imipramine