Electroconvulsive shock decreases beta-adrenoceptors despite serotonin lesions.
We have measured the effect of electroconvulsive shock (ECS) on high- and low-affinity [3H]dihydroalprenolol binding in cerebral cortex of control rats and rats with lesions of serotonin neurons. Eleven days of treatment with ECS (once daily) resulted in a decrease in the number of beta-adrenoceptor binding sites for which isoproterenol has high-affinity. Following lesions with 5,7-dihydroxytryptamine, ECS still resulted in a decrease in these receptors. Hence, ECS does not require intact serotonin neurons to decrease the number of high-affinity beta-adrenoceptors.
Stockmeier
C A
CA
Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.
Kellar
K J
KJ
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D004082:Dihydroalprenolol; D004597:Electroshock; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*
D011943:Receptors, Adrenergic, beta; D011985:Receptors, Serotonin; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D004082:Dihydroalprenolol; D007545:Isoproterenol