[Pharmacological analysis of the serotonin- and glutamatergic mechanisms in the suppressive effect of neuroleptics on the pedal self-stimulation of the ventral tectum of the midbrain].
The serotoninergic mechanisms of neostriatum were found to be involved into the suppressive effects of droperidol, fluphenazine, haloperidol, thioridazine but not those of trifluoperazine, clozapine and aminazine on the midbrain ventral tegmentum self-stimulation. The glutamatergic mechanisms of neostriatum and nucleus accumbens septi play a minor role in attenuation of tegmental self-stimulation with droperidol, fluphenazine, trifluoperazine and clozapine but these mechanisms seem to be responsible for the suppression of "reward" phenomenon with haloperidol, thioridazine and aminazine.
Talalaenko
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AN
Boreĭsha
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IK
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003864:Depression, Chemical; D004558:Electric Stimulation; D005971:Glutamates / Q000502:physiology*; D051381:Rats; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects*; D012054:Reinforcement, Psychology; D012653:Self Stimulation / Q000187:drug effects*; D003336:Tectum Mesencephali / Q000187:drug effects*
D014150:Antipsychotic Agents; D005971:Glutamates; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D011985:Receptors, Serotonin
Farmakologicheskiĭ analiz serotonin- i glutamatergicheskikh mekhanizmov v ugnetaiushchem vliianii neĭroleptikov na pedal'nuiu samostimuliatsiiu ventral'noĭ pokryshki srednego mozga.