Lack of amnestic effects of clorazepate on geriatric recall.
Significant amnestic effects in young adults have been found with the short-acting sedative-hypnotic triazolam and the intermediate-acting lorazepam, but not with the longer-acting clorazepate. The effects of placebo and clorazepate 3.75 and 7.5 mg were compared in 43 nonanxious geriatric subjects. Results were consistent with earlier studies, and no significant impairment of immediate or delayed recall was found.
Scharf
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Hirschowitz
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Woods
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Scharf
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D000368:Aged; D000647:Amnesia / Q000139:chemically induced; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003009:Clorazepate Dipotassium / Q000009:adverse effects / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005853:Geriatrics; D006801:Humans; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D008875:Middle Aged; D010919:Placebos; D011897:Random Allocation
D014151:Anti-Anxiety Agents; D010919:Placebos; D003009:Clorazepate Dipotassium