Low plasma cyclic nucleotides in multiple sclerosis.
The concentrations of cyclic AMP and cyclic GMP were estimated in plasma of 26 patients with definite multiple sclerosis (MS) in relapse, and compared to that of 26 sex- and age-matched healthy controls. MS patients had significantly lower levels of both nucleotides. The levels of c-GMP correlated negatively to the Disability Status Scale score.
Markianos
M
M
Athens University Medical School, Eginition Hospital, Greece.
Sfagos
C
C
D000328:Adult; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000503:physiopathology
D000242:Cyclic AMP; D006152:Cyclic GMP