PUVA and UVB inhibit the intra-epidermal accumulation of polymorphonuclear leukocytes.
Healthy volunteers were treated on test areas with UVB irradiation or topical PUVA therapy. The trauma-induced and leukotriene B4 (LTB4)-induced intra-epidermal accumulation of polymorphonuclear leukocytes (PMN) was quantified after these treatments, using elastase as a marker enzyme. Both UVB and PUVA treatment caused a profound inhibition of trauma- and LTB4-induced PMN accumulation. This observation indicates that reduction of the transepidermal migration of PMN might be part of the mechanism of action of UV therapies in psoriasis. Several possibilities are discussed to explain this hypothesis.
Chang
A
A
Department of Dermatology, University of Nijmegen, The Netherlands.
Alkemade
J A
JA
van de Kerkhof
P C
PC
D000328:Adult; D002465:Cell Movement / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D006801:Humans; D007975:Leukotriene B4 / Q000494:pharmacology; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000528:radiation effects*; D011701:PUVA Therapy / Q000009:adverse effects*; D012867:Skin / Q000293:injuries; D014466:Ultraviolet Rays / Q000009:adverse effects*
D007975:Leukotriene B4