Involvement of platelet activating factor in physiological stress in the lizard, Anolis carolinensis.
Platelet activating factor (PAF) and 1-O-alkyl-linked choline-containing phosphoglycerides have been identified in the blood of the lizard, Anolis carolinensis. The level of PAF in the blood of chronically stressed lizards is 250% higher than in that of controls; the blood contains sufficient 1-O-alkyl-linked choline-containing phosphoglycerides to support the synthesis of PAF. Incorporation of PAF is higher in the liver than in the blood; control animals incorporate more PAF than chronically stressed animals. "Lyso"-PAF is the major metabolite in the blood; whereas, in the liver both "lyso"-PAF and "acyl"-PAF are predominant products. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine:acetylhydrolase activity in the chronically stressed or corticosterone-implanted lizards is increased 2- to 3-fold over the control. Involvement of PAF in the physiological response to psychological stress is indicated.
Lenihan
D J
DJ
Greenberg
N
N
Lee
T C
TC
D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008116:Lizards / Q000502:physiology*; D008297:Male; D010972:Platelet Activating Factor / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology*; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D013312:Stress, Physiological / Q000503:physiopathology*
D010972:Platelet Activating Factor; C028207:1-alkyl-2-acetyl-sn-glycero-3-phosphocholine-acetylhydrolase; D002265:Carboxylic Ester Hydrolases