Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice.
Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.
Low
M J
MJ
Lechan
R M
RM
Hammer
R E
RE
Brinster
R L
RL
Habener
J F
JF
Mandel
G
G
Goodman
R H
RH
D000818:Animals; D004274:DNA, Recombinant / Q000378:metabolism; D005796:Genes; D005818:Genetic Engineering; D006801:Humans; D007124:Immunoenzyme Techniques; D007986:Luteinizing Hormone / Q000378:metabolism; D008668:Metallothionein / Q000235:genetics*; D051379:Mice; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D051381:Rats; D013004:Somatostatin / Q000235:genetics* / Q000378:metabolism
D004274:DNA, Recombinant; D013004:Somatostatin; D007986:Luteinizing Hormone; D008668:Metallothionein