Cholesterol synthesis and HMG CoA reductase activity during hepatocarcinogenesis in rats.
Two treatment regimes were used to produce preneoplastic foci (as determined by the presence of gamma-glutamyl transferase) in rat liver. Increased [14C]acetate incorporation into cholesterol and 3-hydroxy-3-methyl glutaryl CoA reductase activity were associated with high levels of gamma-glutamyl transpeptidase and foci formation. Dietary feedback inhibition of both [14C]acetate incorporation and 3-hydroxy-3-methyl glutaryl CoA reductase activity was reduced at a selected time when gamma-glutamyl transpeptidase activity was high. These changes could not be accounted for by a regenerative response in the liver.
Gregg
R G
RG
Davidson
M
M
Wilce
P A
PA
D015073:2-Acetylaminofluorene / Q000494:pharmacology; D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis*; D004052:Diethylnitrosamine / Q000494:pharmacology; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D011230:Precancerous Conditions / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D004052:Diethylnitrosamine; D002784:Cholesterol; D015073:2-Acetylaminofluorene; D006903:Hydroxymethylglutaryl CoA Reductases; D005723:gamma-Glutamyltransferase; D010634:Phenobarbital