Age-related changes in monoamine oxidase and semicarbazide-sensitive amine oxidase activities of rat aorta.
Aorta MAO-A and SSAO activities were measured on young (3 months) and old (23-26 months) rats. A significant decrease (30-40%) in SSAO activity was found with benzylamine as substrate and the decrease was due to a reduction in Vmax. No significant changes in MAO-A activity were found in the aorta of old rats. beta-PEA is oxidized mainly by SSAO in rat aorta. However, the significance of this is unclear since the physiological role of that enzyme remains unknown.
Cao Danh
H
H
Strolin Benedetti
M
M
Dostert
P
P
Mousset
A
A
D000375:Aging; D000818:Animals; D001013:Aorta, Thoracic / Q000201:enzymology; D003641:Deamination; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D009124:Muscle Proteins / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000201:enzymology*; D010627:Phenethylamines / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012663:Semicarbazides / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism
D009124:Muscle Proteins; D010627:Phenethylamines; D012663:Semicarbazides; C029261:phenethylamine; D012701:Serotonin; D008995:Monoamine Oxidase