title: Inhibition of adhesion of viridans streptococci to fibronectin-coated hydroxyapatite beads by lipoteichoic acid.
abstract: Fibronectin-coated hydroxyapatite (FnHA) beads were used in a model adhesion assay to isolate the lipoteichoic acid (LTA) mediated adhesion of oral streptococci. Representative strains of the commonly isolated viridans streptococci were incubated with FnHA beads in the presence and absence of exogenous LTA. The LTA inhibited the adhesion of all strains to a greater or lesser extent, but only a very few strains were inhibited by more than 90%. Strains of Streptococcus sanguis Type II and Streptococcus mitis which synthesize an amphiphile other than LTA were also inhibited. The findings provided circumstantial evidence for the involvement of LTA in the adhesion of this group of oral bacteria.
authors.affiliation: Department of Oral Biology, The University, Newcastle upon Tyne, UK.
authors.forename: S D
authors.initials: SD
authors.lastname: Hogg
authors.forename: J E
authors.initials: JE
authors.lastname: Manning
mesh_terms: D001422:Bacterial Adhesion / Q000187:drug effects*; D017886:Durapatite; D005353:Fibronectins / Q000378:metabolism*; D006882:Hydroxyapatites / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008863:Microspheres; D013291:Streptococcus / Q000378:metabolism*; D013295:Streptococcus mutans / Q000187:drug effects / Q000378:metabolism; D013298:Streptococcus sanguis / Q000187:drug effects / Q000378:metabolism; D013682:Teichoic Acids / Q000494:pharmacology*
chemical_list: D005353:Fibronectins; D006882:Hydroxyapatites; D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid; D017886:Durapatite