Effects of triamterene and amiloride on urinary sediment in hypertensive patients taking hydrochlorothiazide.
In a crossover study of 26 hypertensive patients, the effects of triamterene (50 mg/day) and amiloride (5 mg/day) on urinary sediment were compared. Each drug was given for one month and all patients also received hydrochlorothiazide (50 mg/day). An abnormal urinary sediment--evident grossly as a reddish-brown precipitate after routine staining procedures and microscopically as characteristic reddish-brown crystals and casts, as previously described--was identified in 14 of 26 (54%) triamterene urine samples but in none of the amiloride samples. Results of renal function tests were similar for both drugs. In a clinic population of more than 1000 hypertensive patients over 4 years, interstitial nephritis was diagnosed in 4, all of whom were taking a triamterene-containing combination diuretic. It is possible that triamterene is a factor in the aetiology of interstitial nephritis.
Spence
J D
JD
Wong
D G
DG
Lindsay
R M
RM
D000584:Amiloride / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003460:Crystallization; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage*; D006973:Hypertension / Q000188:drug therapy / Q000652:urine*; D007669:Kidney Calculi / Q000139:chemically induced / Q000652:urine; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000652:urine; D011719:Pyrazines / Q000008:administration & dosage*; D011897:Random Allocation; D014223:Triamterene / Q000008:administration & dosage* / Q000009:adverse effects
D011719:Pyrazines; D006852:Hydrochlorothiazide; D000584:Amiloride; D014223:Triamterene