title: Creutzfeldt-Jakob disease after administration of human growth hormone.
abstract: A 2-year-old girl had a craniopharyngioma removed in 1964. She received human growth hormone (HGH) twice a week from July, 1972, until July, 1976. In March, 1984, a subacute dementing illness developed with neurological signs that included pronounced cerebellar ataxia. A clinical diagnosis of Creutzfeldt-Jakob disease (CJD) was made. The patient died in February, 1985. Necropsy revealed a spongiform encephalopathy compatible with the transmissible form of CJD. HGH administration may be implicated in the transmission of the disease in this case.
authors.forename: J
authors.initials: J
authors.lastname: Powell-Jackson
authors.forename: R O
authors.initials: RO
authors.lastname: Weller
authors.forename: P
authors.initials: P
authors.lastname: Kennedy
authors.forename: M A
authors.initials: MA
authors.lastname: Preece
authors.forename: E M
authors.initials: EM
authors.lastname: Whitcombe
authors.forename: J
authors.initials: J
authors.lastname: Newsom-Davis
mesh_terms: D002675:Child, Preschool; D003397:Craniopharyngioma / Q000188:drug therapy; D007562:Creutzfeldt-Jakob Syndrome / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D013006:Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D013997:Time Factors
chemical_list: D013006:Growth Hormone