title: Neuropeptide Y (NPY)-like immunoreactivity in rat sympathetic neurons and small granule-containing cells.
abstract: The distribution of neuropeptide Y-like immunoreactivity (NPY-LI) was examined in the rat superior cervical and hypogastric ganglia. NPY-LI was localized in the majority of the sympathetic neurons, a few small granule-containing (SGC) cells and nerve terminals. Most of the NPY-immunoreactive sympathetic neurons were also tyrosine hydroxylase (TH)-immunoreactive but in hypogastric ganglia few neurons with NPY-LI were devoid of TH-immunoreactivity. Electron microscopically NPY-LI was found in the Golgi complexes of sympathetic neurons, in large cytoplasmic granules (100-150 nm in diameter) of the SGC cells and in large dense-cored vesicles (80-100 nm in diameter) of the nerve terminals. NPY-LI coexists mainly with noradrenaline in sympathetic neurons, and may have regulatory functions in sympathetic ganglia and in target organs.
authors.forename: R
authors.initials: R
authors.lastname: Järvi
authors.forename: P
authors.initials: P
authors.lastname: Helén
authors.forename: M
authors.initials: M
authors.lastname: Pelto-Huikko
authors.forename: A
authors.initials: A
authors.lastname: Hervonen
mesh_terms: D000818:Animals; D005728:Ganglia, Sympathetic / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000378:metabolism; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009478:Neuropeptide Y; D051381:Rats; D011919:Rats, Inbred Strains; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D014446:Tyrosine 3-Monooxygenase