The effect of WR 149024 on survival following hemorrhage in conscious rats.
The effect of WR 149024, an alpha-receptor antagonist, on survival following hemorrhage with no volume replacement therapy, was investigated. WR 149024 (either 5.0 or 50.0 mg/kg) was administered intraperitoneally (i.p.) to conscious rats during exsanguination. Both WR 149024 treatments caused a significant decrease in survival (P less than 0.021), compared with water-injected controls.
Brown
D F
DF
Bellamy
R F
RF
D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D008297:Male; D011073:Polyamines / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000401:mortality
D000317:Adrenergic alpha-Antagonists; D011073:Polyamines; C023765:WR 149024