Diffuse somatostatin-immunoreactive D-cell hyperplasia in the stomach and duodenum.
This paper presents the first case of extensive, diffuse, somatostatin-immunoreactive D-cell hyperplasia in the human stomach and duodenum. It occurred in a 37-yr-old woman, who showed clinical signs of dwarfism, obesity, dryness of the mouth, and goiter. The density of the distribution of D cells was increased 39-fold in the stomach fundus, 23-fold in the proximal antrum, 25-fold in the distal antrum, and 31-fold in the upper duodenum in comparison with normal values. At the same time, the gastrin-immunoreactive cells were increased 2.3-fold in the antrum. Although the range in size of the D cells was within normal limits in all regions examined, the G cells showed pronounced hypertrophy of up to 127%. A possible relationship between the immuno-histochemical findings and the clinical picture is discussed.
Holle
G E
GE
Spann
W
W
Eisenmenger
W
W
Riedel
J
J
Pradayrol
L
L
D000328:Adult; D004386:Duodenum / Q000473:pathology*; D004392:Dwarfism / Q000209:etiology; D005260:Female; D006042:Goiter / Q000209:etiology; D006801:Humans; D009765:Obesity / Q000209:etiology; D013004:Somatostatin / Q000032:analysis*; D013270:Stomach / Q000473:pathology*; D013577:Syndrome; D014987:Xerostomia / Q000209:etiology
D013004:Somatostatin