Gossypol and Na+, K+ ATPase from human erythrocytes.
The inhibition of Na+, K+ ATPase by gossypol has been proposed as a mechanism for the hypokalemia occurring in some patients receiving this drug. Gossypol acetic acid, 3 microM (higher concentration than present clinically), did not inhibit this enzyme prepared from erythrocytes from 5 humans. Thus, it is unlikely that gossypol inhibition of the usual form of this enzyme is the mechanism for the initiation of the hypokalemia.
Drayer
D E
DE
Department of Pharmacology, Cornell University Medical College, New York, NY 10021.
Reidenberg
M M
MM
D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D006072:Gossypol / Q000494:pharmacology*; D006801:Humans; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*
D000254:Sodium-Potassium-Exchanging ATPase; D006072:Gossypol