[Toxicologic evaluation of nitrates entering the body with plant products].
An acute toxicological experiment on rats has been performed. During 30 days the animals got nitrates with water and vegetable food. The activity of glucoso-6-phosphatase, malate dehydrogenase, beta-galactosidase, the content of N-acetylneuraminic acid was determined in liver, kidney and blood serum; the level of methemoglobin in blood was estimated. It was found that the changes of studied indexes are less expressed during nitrate introduction with food than with water; on the level of minimum concentrations the changes in non-specific symptom-complex were more expressed. The maximum innocuous intake of nitrates with vegetables is 500 mg in 24 hours taking into consideration the average weight of an individual (50 kg).
Voronina
L P
LP
Votiakov
A V
AV
Perelygin
V M
VM
D000818:Animals; D005260:Female; D005506:Food Contamination; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008291:Malate Dehydrogenase / Q000378:metabolism; D008708:Methemoglobinemia / Q000097:blood; D009566:Nitrates / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats; D013997:Time Factors; D014675:Vegetables / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity; D001616:beta-Galactosidase / Q000378:metabolism
D009566:Nitrates; D014874:Water Pollutants, Chemical; D008291:Malate Dehydrogenase; D005952:Glucose-6-Phosphatase; D001616:beta-Galactosidase
Toksikologicheskaia otsenka nitratov, postupaiushchikh v organizm s rastitel'nymi produktami.