Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells.
Calmodulin-activated, adenylate cyclase toxin, a virulence factor produced by the human respiratory pathogen Bordetella pertussis, elicits marked accumulation of cyclic AMP in cell lines from rat pituitary tumors. This effect is associated with and apparently responsible for an enhanced release of prolactin and/or growth hormone from GH3, GH4C1 and 235-1 cells. The utility of this novel toxin in probing cyclic AMP-mediated responses is supported by these observations and studies with pertussis and cholera toxins.
Weiss
J
J
Hewlett
E L
EL
Cronin
M J
MJ
D037361:Adenylate Cyclase Toxin; D000262:Adenylyl Cyclases / Q000494:pharmacology*; D000527:Alprostadil / Q000494:pharmacology; D000818:Animals; D001886:Bordetella pertussis / Q000032:analysis; D002460:Cell Line; D002772:Cholera Toxin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism*; D007700:Kinetics; D010911:Pituitary Neoplasms / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology; D010566:Virulence Factors, Bordetella / Q000494:pharmacology
D037361:Adenylate Cyclase Toxin; D010566:Virulence Factors, Bordetella; D013004:Somatostatin; D011388:Prolactin; D013006:Growth Hormone; D002772:Cholera Toxin; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D000527:Alprostadil