Odor and taste aversions conditioned in anesthetized rats.
Conditioned flavor aversions (CFA) are acquired by anesthetized rats but effects of various anesthetics on acquisition of aversions for separate odor and taste components are unknown. In Experiment 1, rats drank tomato juice and then were tranquilized with "Innovar-Vet" or "Rompun" before receiving injections of lithium chloride. Neither drug interfered with acquisition of aversions. Innovar-Vet alone produced no aversions; Rompun alone produced mild aversions but did not enhance aversions when combined with lithium. In Experiments 2 and 3, rats received a compound odor/taste cue as they drank and then were anesthetized with pentobarbital before lithium injections. Anesthesia alone produced negligible aversions but facilitated taste-lithium aversions. During odor tests, odor aversions were weaker than taste aversions. These data extend previous work and suggest that CFA does not result from ordinary classical conditioning. A tripartite notation that unites CFA and classical conditioning is discussed.
Bermudez-Rattoni
F
F
Instituto de Fisiologia Celular, Universidad Nacional Autónoma de México, Distrito.
Forthman
D L
DL
Sanchez
M A
MA
Perez
J L
JL
Garcia
J
J
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D002712:Chlorides; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D008094:Lithium; D018021:Lithium Chloride; D008297:Male; D009812:Odorants; D009833:Olfactory Pathways / Q000187:drug effects / Q000502:physiology*; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000502:physiology*; D014991:Xylazine / Q000494:pharmacology
D000777:Anesthetics; D002712:Chlorides; D014991:Xylazine; D008094:Lithium; D018021:Lithium Chloride; D010424:Pentobarbital