title: Collagenase-like peptidase activity in serum from patients with rheumatoid arthritis.
abstract: The activities of collagenase-like peptidase, estimated by using (succinyl-Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro)-4-methylcoumaryl-7-amide as substrate, and of dipeptidyl-aminopeptidase IV were decreased in the sera from patients with rheumatoid arthritis. Both enzymes bring about the degradation of peptides derived from collagen. A significant positive correlation was observed between the activities of the two serum peptidases.
authors.forename: K
authors.initials: K
authors.lastname: Iwase-Okada
authors.forename: K
authors.initials: K
authors.lastname: Kojima
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Kaku
authors.forename: T
authors.initials: T
authors.lastname: Okazaki
authors.forename: K
authors.initials: K
authors.lastname: Wago
authors.forename: S
authors.initials: S
authors.lastname: Sakakibara
authors.forename: T
authors.initials: T
authors.lastname: Nagatsu
mesh_terms: D001172:Arthritis, Rheumatoid / Q000097:blood / Q000201:enzymology*; D002561:Cerebrovascular Disorders / Q000097:blood / Q000201:enzymology; D003094:Collagen / Q000378:metabolism; D018819:Dipeptidyl Peptidase 4; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000097:blood; D010450:Endopeptidases / Q000097:blood*; D006801:Humans; D008666:Metalloendopeptidases
chemical_list: D003094:Collagen; D010450:Endopeptidases; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D018819:Dipeptidyl Peptidase 4; D008666:Metalloendopeptidases; C022510:thimet oligopeptidase