title: The protection given by pilus and whole cell vaccines of Bacteroides nodosus strain 198 against ovine foot-rot induced by strains of different serogroups.
abstract: A highly purified pilus vaccine prepared from cells of Bacteroides nodosus strain 198 provided a high level of protection against homologous challenge and small, not statistically significant, levels of protection against challenge with 4 other strains each from different serogroups. In a second experiment, a partially purified pilus vaccine from strain 198 induced significant immunity to 1 of 4 heterologous strains which were different from those used in the first experiment. In a third experiment a strain 198 whole cell vaccine produced significant immunity against 3 of 6 heterologous strains used in the first 2 experiments. There was no obvious relationship between the colony type, degree of piliation and level of cross-protection obtained against a particular strain. The results provide further evidence that immunogens associated with, but distinct from, the pilus are involved in cross-protection and that cross-protective antigens are common to some, but not all, strains.
authors.forename: D J
authors.initials: DJ
authors.lastname: Stewart
authors.forename: B L
authors.initials: BL
authors.lastname: Clark
authors.forename: J E
authors.initials: JE
authors.lastname: Peterson
authors.forename: D L
authors.initials: DL
authors.lastname: Emery
authors.forename: E F
authors.initials: EF
authors.lastname: Smith
authors.forename: D A
authors.initials: DA
authors.lastname: Griffiths
authors.forename: I J
authors.initials: IJ
authors.lastname: O'Donnell
mesh_terms: D000372:Agglutination Tests / Q000662:veterinary; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000918:Antibody Specificity; D001428:Bacterial Vaccines / Q000276:immunology*; D001439:Bacteroides / Q000276:immunology* / Q000648:ultrastructure; D005260:Female; D010861:Fimbriae, Bacterial / Q000276:immunology*; D005535:Foot Rot / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines