Amplification of the c-myc oncogene in human plasma-cell leukemia.
We have examined primary leukemia cells from multiple myeloma and plasma-cell leukemia patients for rearrangement, amplification and expression of c-myc oncogene. No rearrangement or detectable amplification of the c-myc could be found in 21 cases of multiple myeloma. In contrast, 2/3 cases of plasma-cell leukemia showed amplification of the oncogene with concomitant higher level of expression.
Sümegi
J
J
Hedberg
T
T
Björkholm
M
M
Godal
T
T
Mellstedt
H
H
Nilsson
M G
MG
Perlman
C
C
Klein
G
G
D002460:Cell Line; D004262:DNA Restriction Enzymes / Q000378:metabolism; D015245:Deoxyribonuclease BamHI; D015246:Deoxyribonuclease EcoRI; D005784:Gene Amplification; D006801:Humans; D007952:Leukemia, Plasma Cell / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D011061:Poly A / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis; D014158:Transcription, Genetic
D012333:RNA, Messenger; D011061:Poly A; D004262:DNA Restriction Enzymes; D015245:Deoxyribonuclease BamHI; D015246:Deoxyribonuclease EcoRI