Pharmacokinetics of 3-[bis(2-hydroxyethyl)amino]acetophenone-(4,5-diphenyloxazol-2-yl) hydrazone (ZIMET 98/69) after oral administration to mice.
The pharmacokinetics of the hetarylhydrazone derivative 3H-ZIMET 98/69 after oral administration to mice were studied. The absorption of the drug is incomplete and dose-dependent; elimination proceeds slowly, the serum half-life being of about 30 h. Repeated daily administration of the drug leads to a moderate accumulation of radioactivity in serum as well as in various tissues. The moderate bioavailability after oral administration of ZIMET 98/69 has to be considered as one reason for the high doses necessary for the antiviral action of the drug in vivo.
Amlacher
R
R
Ulbricht
H
H
D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism*; D001682:Biological Availability; D001921:Brain / Q000378:metabolism; D006207:Half-Life; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D051379:Mice; D010080:Oxazoles / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*; D014018:Tissue Distribution
D000998:Antiviral Agents; D010080:Oxazoles; C016864:IMET 98-69