Changes in activity and F1 content of mitochondrial H+-ATPase in regenerating rat liver.
Submitochondrial particles prepared from rat liver during hepatic regeneration exhibit a depressed ATPase activity which is correlated with a decrease in F1 subunit content as shown by SDS-PAGE. Use of an antibody directed against the F1 portion of the H+-ATPase complex demonstrated that there is a definite decrease in the amount of beta-subunit of F1 in both submitochondrial particles and mitochondria from rat liver 24 h after partial hepatectomy.
Buckle
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M
Guerrieri
F
F
Papa
S
S
D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D006498:Hepatectomy; D006867:Hydrolases / Q000378:metabolism; D007120:Immunochemistry; D008115:Liver Regeneration; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D006180:Proton-Translocating ATPases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D006867:Hydrolases; D006180:Proton-Translocating ATPases