Thioacetamide-induced cirrhosis-like liver lesions in rats--usefulness and reliability of this animal model.
Long term administration of thioacetamide (0.03% in tap water) results in a characteristic lesion in rat liver, which corresponds to cirrhosis-like patterns of micronodular cirrhosis type after treatment over 3 months. During its development a reproducible temporal course of biochemical and morphological changes can be recognized. After withdrawal of the toxic agent this lesion persists for about 2 months. Then the cirrhosis-like alterations recede and a proliferation of bile ducts predominates, which is associated with increasing portal fibrosis altering the pattern and relatively enhancing the total collagen content of the liver. Considering these peculiarities, the TAA-model is suitable for investigations into connective tissue metabolism in the fibrotic liver and cirrhosis-like patterns. Search for and test of therapeutic principles should be done during TAA-administration (prophylactic agents) or within 2 months after withdrawal of toxic agents (therapeutics).
Müller
A
A
Department of Internal Medicine, Freidrich Schiller University, Jena, DDR.
Machnik
F
F
Zimmermann
T
T
Schubert
H
H
D000081:Acetamides / Q000633:toxicity*; D000118:Acetylglucosaminidase / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006909:Hydroxyproline / Q000032:analysis; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D008103:Liver Cirrhosis / Q000139:chemically induced*; D003012:Microbial Collagenase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013853:Thioacetamide / Q000633:toxicity*; D013997:Time Factors
D000081:Acetamides; D013853:Thioacetamide; D000118:Acetylglucosaminidase; D003012:Microbial Collagenase; D006909:Hydroxyproline