title: [Serologic and clinical study of post-transfusion viral contamination after cardiac surgery. Excluding human immunodeficiency virus].
abstract: The incidence of post-transfusion viral contamination after cardiac surgery is variable but not negligible. The serological and clinical features of such contamination were determined in a series of 100 consecutive patients seen between June, 1983 and January, 1984. The ELISA technique was used for hepatitis A and B viruses and cytomegalovirus on three samples of blood taken before (S1), and 15 days (S2) and 2 to 3 months (S3) after surgery. In case of hepatitis further investigations were performed for heterophilic infectious mononucleosis antibodies and for hepatitis B virus DNA. The transient appearance at S2 of anti-cytomegalovirus antibodies brought by transfusion was observed in 40% of the cases; seroconversion occurred in 4% (cytomegalovirus 3, hepatitis B virus 1), and 5% of the patients developed clinical and biochemical hepatitis without serological markers.
authors.affiliation: Laboratoire de virologie, CHU de Caen.
authors.forename: J
authors.initials: J
authors.lastname: Petitjean
authors.forename: M C
authors.initials: MC
authors.lastname: Khayat
authors.forename: F
authors.initials: F
authors.lastname: Laforet
authors.forename: M
authors.initials: M
authors.lastname: Quibriac
authors.forename: F
authors.initials: F
authors.lastname: Freymuth
authors.forename: A
authors.initials: A
authors.lastname: Khayat
authors.forename: C
authors.initials: C
authors.lastname: Evrard
authors.forename: M
authors.initials: M
authors.lastname: Thomas
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D006348:Cardiac Surgical Procedures; D003586:Cytomegalovirus Infections / Q000209:etiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005112:Extracorporeal Circulation / Q000009:adverse effects*; D005260:Female; D006506:Hepatitis A / Q000209:etiology*; D006509:Hepatitis B / Q000209:etiology*; D006801:Humans; D008297:Male; D012307:Risk Factors; D065227:Transfusion Reaction
chemical_list: D000914:Antibodies, Viral
vernacular_title: Etude sérologique et clinique des contaminations virales post-transfusionnelles après chirurgie cardiaque. En dehors du virus d'immunodéficience humaine.