Pathogenetic and functional characterization of lymphocytes in influenza patients.
The kinetics of acrocentric chromosome associations and chromosome aberrations in peripheral blood and pleural exudate lymphocytes has been studied in 25 influenza patients and 7 exudative pleurisy patients. Lymphocytes without associations and with 2 associated acrocentric chromosomes were activated in the body, since their frequency appeared to be positively correlated with the immunoresponsiveness indices and with clinical symptoms. The number of these lymphocytes in pleural exudate was 2.5 times higher than in the peripheral blood. When comparing the frequency of chromosome aberrations in the patients' lymphocytes to the level of immunity, cytogenetic changes corresponded to the indices of cellular rather than humoral immunity.
Frolov
A K
AK
Frolov
V K
VK
Tuinov
V A
VA
Sotnik YuP
Lebedinsky
A P
AP
Nikolenko YuI
D000293:Adolescent; D000328:Adult; D000917:Antibody Formation; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000648:ultrastructure*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007111:Immunity, Cellular; D007251:Influenza, Human / Q000235:genetics* / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology; D008875:Middle Aged; D010998:Pleurisy / Q000235:genetics* / Q000276:immunology