Adrenaline and noradrenaline excretion in placebo treated patients in the Medical Research Council Hypertension Trial and in matched normotensive controls.
The 24-h excretion of adrenaline and noradrenaline was measured in 268 untreated essential hypertensives and in 268 age- and sex-matched controls. No significant difference was found between the groups. However, in the control group alone, a multiple regression analysis showed a highly significant correlation between systolic blood pressure and both noradrenaline (P = 0.0006) and adrenaline (P = 0.0001). These results suggest that any role for elevated sympatho-adrenal activity in long-term blood pressure regulation is limited to the time before hypertension is established.
Brown
M J
MJ
Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, UK.
Causon
R C
RC
Brennan
P
P
Greenberg
G
G
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D004837:Epinephrine / Q000652:urine*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000652:urine*; D010919:Placebos; D012044:Regression Analysis
D010919:Placebos; D009638:Norepinephrine; D004837:Epinephrine