Phenobarbitone enhances [35S]TBPS binding to extensively washed rat cortical membranes.
Pentobarbitone and phenobarbitone enhance [35S]TBPS binding to extensively washed rat cortical membranes with ED50 values of 15 and 120 microM, respectively, indicative of an interaction with the chloride ionophore part of the GABA-receptor different from the TBPS binding site, but allosterically coupled to this site.
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Drejer
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D000818:Animals; D001665:Binding Sites; D001643:Bridged Bicyclo Compounds / Q000378:metabolism*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000378:metabolism*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008566:Membranes / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; C037476:tert-butylbicyclophosphorothionate; D010634:Phenobarbital