Strategies for the prevention of malaria in travellers: comparison of drug regimens by means of risk-benefit analysis.
A risk-benefit analysis has been used to balance the risks to travellers of death from malaria against the toxicity of various drug regimens. The mortality of travellers who take no prophylaxis is estimated to be surprisingly low, and it is concluded that most travellers, even in areas of drug resistance should take only non-toxic drugs, such as a combination of chloroquine and proguanil.
Peto
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Gilks
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CF
D000349:Africa; D000962:Antimalarials / Q000008:administration & dosage* / Q000009:adverse effects; D001208:Asia; D001499:Bayes Theorem; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D006801:Humans; D008288:Malaria / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000187:drug effects; D002727:Proguanil / Q000008:administration & dosage; D011803:Quinine / Q000008:administration & dosage; D012306:Risk; D014195:Travel; D006113:United Kingdom
D000962:Antimalarials; D011803:Quinine; D002727:Proguanil