Oligosaccharides in molecular recognition.
The development, organization and growth of complex organisms as well as their interactions with the environment involve an intricate array of molecular recognition events. There is an increased awareness of the involvement of oligosaccharides in many of these processes. In this article, studies of oligosaccharide antigenicity, and the way these have been interpreted with respect to oligosaccharide function will be discussed. In addition, examples of oligosaccharides as receptor, first, as receptors and determinants of susceptibility to an exogenous infective agent and secondly, as recognition structures possibly involved in endogenous interactions, will be described. This will be followed by a discussion of the recent hypothesis in which oligosaccharides are envisaged as recognition structures and integral components of cell growth-regulating networks. Finally, an outline of new strategies for decoding the information content in glycoprotein oligosaccharides will be given.
Feizi
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Section of Glycoconjugate Research, M.R.C. Clinical Research Centre, Harrow, Middlesex, U.K.
D000941:Antigens / Q000276:immunology; D006023:Glycoproteins; D037102:Lectins / Q000378:metabolism; D015335:Molecular Probes; D009844:Oligosaccharides / Q000276:immunology / Q000378:metabolism*; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000378:metabolism
D000941:Antigens; D006023:Glycoproteins; D037102:Lectins; D015335:Molecular Probes; D009844:Oligosaccharides; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; C032193:glycoprotein receptor GPIb-IX