High frequency of spontaneous histiocytic sarcomas in BDII/Han rats.
Histopathological findings and anatomical distribution of histiocytic sarcomas found in an uncommonly high frequency (50 of 399 rats) in the BD II/Han inbred strain are reported. The incidence of the tumours in male rats was significantly higher than in females. This was in part attributed to a shorter life expectancy of female rats. Tumours identified were composed of histiocytic cells. Other histological features included Langhans-type giant cells, palisading of histiocytes around necrosis and granuloma-like arrangements of cells. The highest incidence of histiocytic sarcomas was found in the subcutis. Other organs frequently involved were lungs and liver. The histopathological findings in BD II/Han rats are compared with previously reported histiocytic sarcomas in other strains of rat.
Kaspareit-Rittinghausen
J
J
Department of Pathology, Central Institute for Laboratory Animal Breeding, Hannover, FRG.
Deerberg
F
F
D000818:Animals; D005260:Female; D006644:Histiocytes / Q000473:pathology / Q000662:veterinary*; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology / Q000662:veterinary*; D008113:Liver Neoplasms / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology / Q000662:veterinary*