Cytotoxicity of influenza A virus for cultured heart muscle cells.
Neonatal rat heart muscle primary cell cultures were infected with influenza A viruses. Depending on the infectious dose, functional and structural changes of the heart muscle cells could be registered. The system seems suitable for testing the cytotoxicity of different influenza virus strains.
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D000818:Animals; D002470:Cell Survival; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D006321:Heart / Q000382:microbiology*; D009980:Influenza A virus / Q000472:pathogenicity* / Q000502:physiology; D009200:Myocardial Contraction; D009206:Myocardium / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains; D014779:Virus Replication