Effect of dipyridamole on blood glucose and liver cyclic AMP levels and platelet count during endotoxaemia in mice.
1. Blood glucose, liver cyclic AMP (cAMP) levels, and platelet count were studied at different times during a 12 h interval after intravenous (i.v.) endotoxin injection (40 mg/kg) in mice. 2. Blood glucose and liver cAMP levels showed a progressive decrease in endotoxic mice and the decrease was significant after 8 and 12 h. 3. Dipyridamole (50 mg/kg) administered intraperitoneally (i.p.) 7 h post-endotoxin improved blood glucose and liver cAMP levels. 4. Platelet counts were decreased after 1 h in endotoxic mice and remained decreased up to 8 h. Dipyridamole administered soon after endotoxin improved platelet counts in endotoxic mice and increased survival rate to 100%.
Al-Jibouri
L M
LM
Department of Pharmacology, College of Medicine, Baghdad University, Iraq.
Najim
R A
RA
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D004176:Dipyridamole / Q000494:pharmacology*; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010976:Platelet Count
D001786:Blood Glucose; D004731:Endotoxins; D004176:Dipyridamole; D000242:Cyclic AMP