title: The effects of putative anxiolytic compounds (PK 8165, PK 9084 and tracazolate) on the rat corticosterone response.
abstract: The effects were investigated of three putative anxiolytics, thought to act at the GABA-benzodiazepine receptor complex, on basal corticosterone and novelty-induced rise in plasma corticosterone concentrations. The two phenylquinolines, PK 8165 and PK 9084, increased basal concentrations, but reduced the novelty-induced rise in corticosterone; these actions resemble those found with high doses of benzodiazepines. Tracazolate, a pyrazolopyridazine that enhances the binding of benzodiazepines to their receptors, was without significant effect in either situation.
authors.forename: S E
authors.initials: SE
authors.lastname: File
authors.forename: S
authors.initials: S
authors.lastname: Pellow
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D003345:Corticosterone / Q000097:blood*; D008297:Male; D011720:Pyrazoles / Q000627:therapeutic use*; D011804:Quinolines / Q000627:therapeutic use*; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects; D013315:Stress, Psychological / Q000188:drug therapy*
chemical_list: D014151:Anti-Anxiety Agents; D011720:Pyrazoles; D011804:Quinolines; D011963:Receptors, GABA-A; C030079:PK 9084; C030078:pipequaline; C034317:tracazolate; D003345:Corticosterone