Pancreatic somatostatinoma: presentation with recurrent episodes of severe hyperglycaemia and ketoacidosis.
A 47-year-old woman was admitted on four occasions over a four-year period with severe hyperglycaemia associated with marked ketoacidosis. She had weight loss with hepatomegaly and ultrasonography indicated a pancreatic tumour which was shown to be a somatostatinoma. Resection resulted in prolonged survival. The biochemical and morphological features of this rare tumour are presented, and an explanation for the unusual presentation of a somatostatinoma with episodes of ketoacidosis is given.
Willcox
P A
PA
Department of Medicine, University of Cape Town, South Africa.
Immelman
E J
EJ
Barron
J L
JL
Klaff
L J
LJ
Harries-Jones
E P
EP
Hainsworth
M
M
Millar
R P
RP
D007516:Adenoma, Islet Cell / Q000150:complications*; D016883:Diabetic Ketoacidosis / Q000209:etiology*; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000209:etiology*; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology; D012008:Recurrence; D013005:Somatostatinoma / Q000097:blood / Q000150:complications* / Q000473:pathology
D006728:Hormones