HLA-matching and pretransplant blood transfusions in cadaveric renal transplantation--a changing picture with cyclosporin.
613 patients were included in a study to assess the extent to which HLA-matching and pretransplant blood transfusions affect the outcome of cadaveric renal transplantation in patients treated with cyclosporin and low doses of prednisolone. Matching for the HLA-DR-antigens significantly reduced the frequency of rejection episodes, but neither HLA-matching nor pretransplant blood transfusions influenced the patient and graft survival rates.
Lundgren
G
G
Groth
C G
CG
Albrechtsen
D
D
Brynger
H
H
Flatmark
A
A
Frödin
L
L
Gäbel
H
H
Husberg
B
B
Klintmalm
G
G
Maurer
W
W
D000704:Analysis of Variance; D000906:Antibodies / Q000032:analysis; D001803:Blood Transfusion; D002102:Cadaver; D003524:Cyclosporins / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000187:drug effects; D006085:Graft Survival / Q000187:drug effects; D006680:HLA Antigens / Q000032:analysis*; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D007668:Kidney / Q000276:immunology; D016030:Kidney Transplantation; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D011300:Preoperative Care; D012086:Reoperation; D013601:T-Lymphocytes / Q000276:immunology
D000906:Antibodies; D003524:Cyclosporins; D006680:HLA Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D011239:Prednisolone