Clonidine and enphenamic acid interaction study in dogs.
The drug interaction between clonidine (Cl) and enphenamic acid (En.A.), a newer non-steroidal anti-inflammatory drug (NSAID) was studied in anaesthetized dogs. Prior administration of En.A. in animals modified the blood pressure response to clonidine. Thus En.A., administered 1 hr before clonidine, potentiated the hypertensive response and blocked the subsequent hypotensive response to clonidine. Intracerebroventricular administration of En.A. did not affect the usual blood pressure response to clonidine. Similarly, this interaction was not observed in reserpinized animals and it was only partially blocked in normal dogs, treated with tolazoline. It is concluded that En.A. interferes with blood pressure responses to clonidine and that this interaction is probably of a peripheral, vascular, nature.
Dalvi
S S
SS
Kshirsagar
N A
NA
Satoskar
R S
RS
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000758:Anesthesia; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003000:Clonidine / Q000494:pharmacology*; D004285:Dogs; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D013045:Species Specificity; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D000893:Anti-Inflammatory Agents; D062367:ortho-Aminobenzoates; C019126:enfenamic acid; D012110:Reserpine; D003000:Clonidine; D009638:Norepinephrine; D004837:Epinephrine