Controlled trial of small bipolar probe in bleeding peptic ulcers.
204 of 460 patients with upper gastrointestinal bleeding admitted to a busy district hospital were found to be bleeding from peptic ulcers or to have signs of recent haemorrhage at endoscopy within 24 h of admission. To determine if the small bipolar probe could stop bleeding or rebleeding, patients were allocated to electrocoagulation (101) or not (103); other aspects of treatment were identical. Groups were stratified by ulcer site to give similar numbers in each. To allow for differences in sex, age, initial haemoglobin, presence of other diseases, and shock, data were analysed by logistic regression. Fewer patients in the treated group (17) continued to bleed or rebled compared with controls (34). Rebleeding and mortality rates in the treated group were higher early in the trial, suggesting the need for experience in application of the probe. Further improvements in technology and technique may result in significant reductions in mortality.
O'Brien
J D
JD
Day
S J
SJ
Burnham
W R
WR
D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000601:surgery; D004564:Electrocoagulation / Q000295:instrumentation* / Q000379:methods; D005773:Gastroscopy; D006801:Humans; D010438:Peptic Ulcer Hemorrhage / Q000601:surgery*; D011897:Random Allocation; D012008:Recurrence; D012044:Regression Analysis; D013276:Stomach Ulcer / Q000601:surgery