title: Haemodynamic effects of pindolol in essential hypertension with special reference to resistance vessels in the forearm during maximal vasodilatation.
abstract: Eleven patients, mean age 45 years, with previously untreated hypertension (WHO stage I) were treated over 16 months with pindolol in dosages of 5-30 mg/day. The effects on blood pressure and peripheral vascular resistance (PR) were studied before and after 2 and 16 months of treatment. Recordings were performed at rest, and after maximal vasodilatation obtained by ischaemic work to exhaustion with a hand-ergometer. Blood pressure was significantly reduced after both 2 and 16 months of treatment (P < 0.001). During treatment small reductions in heart rate were seen at rest but not after maximal vasodilatation (P < 0.02 and NS, respectively). At rest there was a great variability and no significant changes in PR. Peripheral vascular resistance after maximal vasodilatation was significantly reduced after both 2 and 16 months of treatment (P < 0.005 and P < 0.01, respectively). We conclude that long-term treatment with pindolol may give a regression of structural vascular changes.
authors.affiliation: Department of Internal Medicine, Sabbatsbergs Hospital, Stockholm, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Gretzer
authors.forename: H
authors.initials: H
authors.lastname: Dunér
authors.forename: B
authors.initials: B
authors.lastname: Lagerbäck
mesh_terms: D000328:Adult; D005260:Female; D005542:Forearm / Q000098:blood supply; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010869:Pindolol / Q000627:therapeutic use*; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects*; D014664:Vasodilation / Q000502:physiology*
chemical_list: D010869:Pindolol