Inappropriate ACTH concentrations in two patients with functioning adrenocortical carcinoma.
Two female patients with functioning adrenocortical carcinomas had plasma ACTH detectable by RIA at presentation. In both patients there was evidence for biological activity of ACTH. There was no evidence for an ectopic source of ACTH, nor for a pituitary tumour. Urinary steroid analysis showed patterns of multiple hormone secretion characteristic of adrenocortical carcinomas. The finding of detectable ACTH concentrations in a patient with Cushing's syndrome does not exclude the presence of an adrenocortical tumour.
Law
A
A
Endocrine Unit, Hammersmith Hospital.
Hague
W M
WM
Daly
J G
JG
Honour
J W
JW
Taylor
N
N
Jeffcoate
S L
SL
Himsworth
R L
RL
Joplin
G F
GF
D000310:Adrenal Gland Neoplasms / Q000097:blood* / Q000648:ultrastructure / Q000652:urine; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000097:blood* / Q000648:ultrastructure / Q000652:urine; D005260:Female; D006801:Humans; D013256:Steroids / Q000652:urine
D013256:Steroids; D000324:Adrenocorticotropic Hormone