title: A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences.
abstract: A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement that replaced the extracellular domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle tropomyosin molecule.
authors.forename: D
authors.initials: D
authors.lastname: Martin-Zanca
authors.forename: S H
authors.initials: SH
authors.lastname: Hughes
authors.forename: M
authors.initials: M
authors.lastname: Barbacid
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002471:Cell Transformation, Neoplastic; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis; D006801:Humans; D009857:Oncogenes; D011061:Poly A / Q000032:analysis; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D014335:Tropomyosin / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D014335:Tropomyosin; D011061:Poly A; D004247:DNA; D011505:Protein-Tyrosine Kinases