title: Amiodarone does not affect digoxin kinetics in the rabbit.
abstract: It has been reported that amiodarone may interact with digoxin in man. We investigated the effects of amiodarone pretreatment (35 mg kg-1 day-1) on the pharmacokinetics of a single dose of digoxin (50 micrograms kg-1) in 6 rabbits. Total body clearance of digoxin was 138.84 +/- 44.67 and 147.99 +/- 29.17 ml min-1, serum half life 187.9 +/- 60.9 and 181.34 +/- 25.57 min and volume of distribution 35.4 +/- 8.54 and 37.8 +/- 3.9 litres before and after amiodarone treatment, respectively. None of these changes were statistically significant. We conclude that the presence of an amiodarone-induced change in digoxin pharmacokinetics in the rabbit was not evident and that other animal models will be necessary for studying this interaction.
authors.forename: D C
authors.initials: DC
authors.lastname: Buss
authors.forename: P A
authors.initials: PA
authors.lastname: Routledge
mesh_terms: D000638:Amiodarone / Q000494:pharmacology*; D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D004077:Digoxin / Q000097:blood*; D004347:Drug Interactions; D006207:Half-Life; D007700:Kinetics; D011817:Rabbits
chemical_list: D001572:Benzofurans; D004077:Digoxin; D000638:Amiodarone