The inheritance of skeletal muscle fibre composition in mice.
Two inbred strains of mice C3H/HE and SWR, and generations produced by intercrossing, were studied to investigate the effect of heredity on muscle composition. The data were found to be consistent with a polygenic mode of inheritance. No simple effect of sex-linkage or maternal influence was evident. The heritability of fibre type percentage total fibre number and the relative size of Type I and Type II fibres were highly significant. Principal component analysis yielded a "genetic" vector which accounted for 57% of the variation in muscle fibre composition. Patterns of covariance of fibre type percentage, total fibre number and relative sizes of Type I and Type II fibres showed a single correlated response.
Nimmo
M A
MA
Wilson
R H
RH
Snow
D H
DH
D000818:Animals; D001823:Body Composition; D003433:Crosses, Genetic; D005260:Female; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics*; D008815:Mice, Inbred Strains / Q000235:genetics*; D009132:Muscles / Q000032:analysis*; D013045:Species Specificity