title: Intramuscular bioavailability of chlorazepate as compared to diazepam.
abstract: Dipotassium chlorazepate (DPC) and diazepam (DZM) were given i.m. and i.v. to 6 healthy volunteers in doses of 20 mg (48.9 mumol) DPC and 15 mg (52.0 mumol) DZM. The interval between the injections was at least 1 week. Plasma samples were analyzed for DPC and DZM by HPLC. The bioavailability of DPC and DZM after i.m. administration, determined from computer calculated AUCs, was 1.04 and 0.85, respectively.
authors.forename: A
authors.initials: A
authors.lastname: Bertler
authors.forename: S
authors.initials: S
authors.lastname: Lindgren
authors.forename: J O
authors.initials: JO
authors.lastname: Magnusson
authors.forename: H
authors.initials: H
authors.lastname: Malmgren
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000378:metabolism*; D001682:Biological Availability; D003009:Clorazepate Dipotassium / Q000008:administration & dosage / Q000378:metabolism*; D003975:Diazepam / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male
chemical_list: D014151:Anti-Anxiety Agents; D003009:Clorazepate Dipotassium; D003975:Diazepam