title: Neuropeptides in human cerebrospinal fluid.
abstract: Ten neuropeptides were measured by RIA in human cerebrospinal fluid obtained from 30 normal volunteers. The levels of seven peptides (corticotropin releasing factor, adrenocorticotropin, vasoactive intestinal peptide, somatostatin, beta-endorphin, beta-lipotropin, and the N-terminal fragment of proopiomelanocortin) were highly, positively correlated with one another. This result is consistent with the hypothesis that cerebrospinal fluid levels of these seven peptides are a function of some common regulatory factor, such as shared release into the cerebrospinal fluid.
authors.forename: W H
authors.initials: WH
authors.lastname: Berrettini
authors.forename: J I
authors.initials: JI
authors.lastname: Nurnberger
authors.forename: P W
authors.initials: PW
authors.lastname: Gold
authors.forename: M
authors.initials: M
authors.lastname: Chretien
authors.forename: G P
authors.initials: GP
authors.lastname: Chrousos
authors.forename: J S
authors.initials: JS
authors.lastname: Chan
authors.forename: L R
authors.initials: LR
authors.lastname: Goldin
authors.forename: E S
authors.initials: ES
authors.lastname: Gershon
mesh_terms: D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000134:cerebrospinal fluid; D000328:Adult; D003346:Corticotropin-Releasing Hormone / Q000134:cerebrospinal fluid; D004723:Endorphins / Q000134:cerebrospinal fluid; D006801:Humans; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000134:cerebrospinal fluid*; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D011333:Pro-Opiomelanocortin / Q000134:cerebrospinal fluid; D013004:Somatostatin / Q000134:cerebrospinal fluid; D014660:Vasoactive Intestinal Peptide / Q000134:cerebrospinal fluid; D001615:beta-Endorphin; D008083:beta-Lipotropin / Q000134:cerebrospinal fluid
chemical_list: D004723:Endorphins; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D001615:beta-Endorphin; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D008083:beta-Lipotropin