[Effect of estrogens and thyroid hormones on the development of isoprenaline-induced myocardiodystrophy].
An experimental study in female rats demonstrated that hyperestrogenemia (unlike hypoestrogenemia or hyperthyroidism) enhanced the myocardial necrotic effect of isoprenaline. There was no clear-cut correlation between the extent of myocardial damage and cAMP phosphodiesterase activity.
Stroev
E A
EA
Stroitelev
V V
VV
Astrakhantsev
A F
AF
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000503:physiopathology*; D000242:Cyclic AMP / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology; D004967:Estrogens / Q000502:physiology*; D005260:Female; D006980:Hyperthyroidism / Q000139:chemically induced / Q000503:physiopathology; D007545:Isoproterenol / Q000633:toxicity*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D010052:Ovariectomy; D051381:Rats; D013963:Thyroid Hormones / Q000502:physiology*; D013974:Thyroxine / Q000494:pharmacology
D004967:Estrogens; D013963:Thyroid Hormones; D004958:Estradiol; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D007545:Isoproterenol; D013974:Thyroxine
Vliianie éstrogenov i tireoidnykh gormonov na razvitie indutsirovannĭ izoprenalinom miokardiodistrofii.