[L-glutamate-activated conductivity in the membrane of isolated pyramidal neurons of the rat hippocampus].
Isolated pyramidal neurons from rat hippocampus were investigated under conditions of intracellular perfusion and voltage clamp using the method of rapid application of extracellular solution. It was found that the L-glutamate-activated current was carried by sodium and potassium ions with PK+/PNa+ ratio about 0.6. The dose-response relationship demonstrated one to one interaction between L-glutamate and membrane receptor with Kd value about 1.1 mmol/l.
Kiksin
N I
NI
Tsyndrenko
A Ia
AIa
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism
D005971:Glutamates; D018698:Glutamic Acid; D012964:Sodium; D011188:Potassium
L-glutamataktiviruemaia provodimost' v membrane izolirovannykh piramidnykh neĭronov gippokampa krysy.