[Organophosphate analogs of biologically active compounds. XIV. Halophosphonate analogs of ATP as acetyl CoA carboxylase inhibitors].
Halophosphonate ATP analogues pp[CHBr]pA and p[CHBr]ppA synthesised from bromomethylenebisphosphonate and adenosine derivatives, proved to be effective competitive inhibitors of Ac-CoA-carboxylase (CE 6.4.1.2) from rat liver (Ki = 0,2 mM). The inhibitory effects of both analogues were reversible and higher than those of some other ATP analogues. Another enzyme, Ac-CoA-synthetase (CE 6.2.1.1), with a different mode of ATP-cleavage showed wider specificity to ATP-analogues than Ac-CoA-carboxylase.
Biriukov
A I
AI
Tarusova
N B
NB
Amontov
S G
SG
Osipova
T I
TI
Goriachenkova
E V
EV
D000106:Acetate-CoA Ligase / Q000037:antagonists & inhibitors*; D000103:Acetyl-CoA Carboxylase / Q000037:antagonists & inhibitors*; D000241:Adenosine; D000255:Adenosine Triphosphate / Q000031:analogs & derivatives; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003066:Coenzyme A Ligases / Q000037:antagonists & inhibitors*; D003600:Cytosol / Q000201:enzymology; D004164:Diphosphonates; D066298:In Vitro Techniques; D008025:Ligases / Q000037:antagonists & inhibitors*; D008099:Liver / Q000201:enzymology; D009206:Myocardium / Q000648:ultrastructure; D011817:Rabbits; D051381:Rats
C046463:5'-adenylyl (beta,gamma-bromomethylene)diphosphonate; D004164:Diphosphonates; C046461:bromomethylenebis(phosphonic acid); D000255:Adenosine Triphosphate; C046462:5'-adenylyl (alpha,beta-bromomethylene)diphosphonate; D008025:Ligases; D003066:Coenzyme A Ligases; D000106:Acetate-CoA Ligase; D000103:Acetyl-CoA Carboxylase; D000241:Adenosine
Fosfororganicheskie analogi biologicheski aktivnykh soedineniĭ. XIV. Galoidfosfonatnye analogi ATP kak ingibitory Ac CoA-karboksilazy.