Cytomegalovirus immunity and T lymphocytes in bone marrow donors and acute graft-versus-host disease.
T lymphocyte subset numbers in bone marrow grafts were correlated with the cytomegalovirus (CMV) antibody status of the donors and with the occurrence of acute graft-versus-host disease (GVHD) in their recipients. We studied whether or not the (previously reported) association between donor CMV antibodies and GVHD could be explained by CMV-related changes in T cell subsets in the marrow grafts. There were no significant correlations between any of the T cell subsets in the marrow grafts and the occurrence of grades II-IV GVHD. A particular subset of CD8+ T cells carrying the HNK1 marker was significantly increased in the marrow grafts of CMV-seropositive donors. Although recipients of marrow from CMV-seropositive donors received an average of five times more CD8+ HNK1+ T cells than those with CMV-seronegative donors, that situation was not associated significantly with the development of GVHD.
Gratama
J W
JW
Department of Immunohematology and Blood Bank, University Medical Center, The Netherlands.
Fibbe
W E
WE
Naipal
A M
AM
Slats
J
J
Stijnen
T
T
D'Amaro
J
J
Bolhuis
R L
RL
The
T H
TH
Janssen
J
J
D000208:Acute Disease; D000914:Antibodies, Viral / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte; D016026:Bone Marrow Transplantation; D003586:Cytomegalovirus Infections / Q000097:blood / Q000276:immunology*; D006086:Graft vs Host Disease / Q000276:immunology / Q000382:microbiology*; D006801:Humans; D010641:Phenotype; D012698:Serologic Tests; D013601:T-Lymphocytes / Q000145:classification*; D014019:Tissue Donors
D000914:Antibodies, Viral; D000945:Antigens, Differentiation, T-Lymphocyte