Calcitonin gene-related peptide: potent vasodilator and major product of calcitonin gene.
In addition to calcitonin and katacalcin, the human calcitonin gene encodes a novel peptide--calcitonin gene-related peptide (CGRP)--a potent vasodilator. A sensitive and specific radioimmunoassay was developed to study plasma levels of CGRP in normal subjects. CGRP circulates at five times the concentration of calcitonin, suggesting that it may be an important physiological regulator of vascular tone and blood flow.
Girgis
S I
SI
Macdonald
D W
DW
Stevenson
J C
JC
Bevis
P J
PJ
Lynch
C
C
Wimalawansa
S J
SJ
Self
C H
CH
Morris
H R
HR
MacIntyre
I
I
D000328:Adult; D000368:Aged; D000818:Animals; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood* / Q000502:physiology; D051381:Rats; D014664:Vasodilation
D009419:Nerve Tissue Proteins; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide