[Neuromediator mechanisms of regulating immune reactions in schizophrenics].
Eighty patients with paranoid schizophrenia were studied for the cell-mediated (T lymphocytes) and humoral (B lymphocytes, immunoglobins A, M and G) immunity. Using stimulants and blockers of dopaminergic (L-DOPA, haloperidol), serotoninergic (reserpine, deseril), cholinergic (galanthamine, benactyzin) and GABA-ergic (lithium hydroxybutyrate, isoniazid) systems, the authors have established that the dopaminergic system intensifies the immune response while serotoninergic, cholinergic and GABA-ergic systems inhibit it. It is postulated that the effect of neuromediatory systems on the immune responses is reciprocal.
Aliev
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D000328:Adult; D001402:B-Lymphocytes; D001921:Brain / Q000503:physiopathology*; D002799:Cholinergic Fibers / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007958:Leukocyte Count; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000502:physiology*; D012563:Schizophrenia, Paranoid / Q000276:immunology*; D012701:Serotonin / Q000502:physiology; D013601:T-Lymphocytes; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D007136:Immunoglobulins; D018377:Neurotransmitter Agents; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D004298:Dopamine
Neĭromediatornye mekhanizmy reguliatsii immunnykh reaktsiĭ u bol'nykh shizofrenieĭ.