Lethality of opioid and antihistaminic combinations in mice.
The lethality of morphine (37.5, 75, and 150 mg/kg) and tripelennamine (10,20,40 and 60 mg/kg), given alone and in combination, was evaluated in mice housed in groups of 16. When given alone, neither drug produced death at any dose. Combining the drugs produced supra-additive effects: some deaths occurred at all combination doses. The lethality of pentazocine (20, 40 and 80 mg/kg) and diphenhydramine (20, 40 and 80 mg/kg), given alone and in combination, also was evaluated. Neither drug alone produced death at any dose. Supra-additive effects were observed when the drugs were combined. These results are similar to earlier findings concerning the lethality of combinations of pentazocine and tripelennamine.
Poling
A
A
Sewell
R G
RG
Gallus
J A
JA
Nearchou
N I
NI
D000818:Animals; D004155:Diphenhydramine / Q000633:toxicity; D004357:Drug Synergism; D005260:Female; D006634:Histamine H1 Antagonists / Q000633:toxicity*; D051379:Mice; D009020:Morphine / Q000633:toxicity; D009294:Narcotics / Q000633:toxicity*; D010423:Pentazocine / Q000633:toxicity; D014309:Tripelennamine / Q000633:toxicity
D006634:Histamine H1 Antagonists; D009294:Narcotics; D014309:Tripelennamine; D009020:Morphine; D004155:Diphenhydramine; D010423:Pentazocine