Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria.
In eastern Thailand, 14 adults with moderately severe falciparum malaria were treated with intravenous amodiaquine dihydrochloride, loading dose 10 mg base/kg infused over 4 h followed by three further intravenous infusions of 5 mg base/kg at 24, 48, and 72 h. All patients were clinically cured--mean fever clearance time 37.8 h (range 24-60), mean parasite clearance time 64.9 h (18-164). There were no serious toxic effects. 33 patients aged over 5 years with uncomplicated falciparum malaria were given oral amodiaquine dihydrochloride (mean total dose 41 mg base/kg over 3 days) combined with erythromycin estolate (mean dose 48 mg base/kg daily for 5 days). 2 patients failed to respond. In the other 31 patients mean fever clearance time was 55.9 h (range 10-104) and mean parasite clearance time was 65.4 h (40-120). In both studies, more than half the patients followed-up had recurrent parasitaemia but reinfection could not be excluded. Parasites isolated from 18 patients were highly resistant to chloroquine in vitro.
Looareesuwan
S
S
Phillips
R E
RE
White
N J
NJ
Karbwang
J
J
Benjasurat
Y
Y
Attanath
P
P
Warrell
D A
DA
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000655:Amodiaquine / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002738:Chloroquine / Q000494:pharmacology*; D004338:Drug Combinations; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D008288:Malaria / Q000188:drug therapy*; D008875:Middle Aged; D010963:Plasmodium falciparum
D004338:Drug Combinations; D000655:Amodiaquine; D004917:Erythromycin; D002738:Chloroquine