title: Triazolam and ethanol interaction: kinetic and dynamic consequences.
abstract: The kinetic and dynamic consequences of the coadministration of triazolam and ethanol were investigated in six normal subjects. Each received three treatments: triazolam, 0.25 mg by mouth, preceded by 1 hour and followed for 7.5 hours by oral ethanol dosed to maintain breath concentrations of 800 to 950 mg/L; placebo and ethanol; and triazolam and orange juice. After ethanol, triazolam total AUC0-infinity increased (mean +/- SD = 21% +/- 18%). Subjects showed greater psychomotor impairment on measures of free recall, postural stability, and hand-eye coordination after the combination than after either drug alone. These dynamic interactions are greater than the kinetic changes.
authors.forename: P
authors.initials: P
authors.lastname: Dorian
authors.forename: E M
authors.initials: EM
authors.lastname: Sellers
authors.forename: H L
authors.initials: HL
authors.lastname: Kaplan
authors.forename: C
authors.initials: C
authors.lastname: Hamilton
authors.forename: D J
authors.initials: DJ
authors.lastname: Greenblatt
authors.forename: D
authors.initials: D
authors.lastname: Abernethy
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D014151:Anti-Anxiety Agents / Q000378:metabolism*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D011897:Random Allocation; D014229:Triazolam / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D014151:Anti-Anxiety Agents; D014229:Triazolam; D000431:Ethanol