[Comparative analysis of the antiamnesic action of a blockade of the benzodiazepine-GABA-ionophore complex and of an activation of the dopaminergic system in the brain of mice].
In experiments on mice by the method of conditioned reaction of passive avoidance and amnesia elicited by the animal delay in the dangerous compartment immediately after electrocutaneous stimulation, antiamnestic effect is demonstrated of pharmacological influences, changing the activity of benzodiazepine-GABA-ionophore complex and dopaminergic system. Comparative analysis of the efficiency of neuropharmacological substances of different actions on synaptic apparatus of the studied transmitter systems in amnesia reduction showed that the greatest effect of improving the reproduction of the conditioned habit was that of the bupropion, the highly specific blockator of dopamine reverse absorption. The obtained results testify that amnesia development is based on activation of the inhibitory GABAergic brain processes and disturbance of dopaminergic system functioning.
Dubrovina
N I
NI
Il'iuchënok
R Iu
RIu
D000647:Amnesia / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D007476:Ionophores; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*
D007476:Ionophores; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A
Sravnitel'nyĭ analiz antiamnesticheskogo deĭstviia blokady benzodiazepin-GAMK-ionoformogo kompleksa i aktivatsii dofaminergicheskoĭ sistemy mozga u mysheĭ.