title: Systemic mastocytosis associated with membranous nephropathy and peripheral neuropathy.
abstract: A report of the occurrence of membranous nephropathy and peripheral neuropathy in a patient with systemic mastocytosis is presented. Previous reviews of patients with systemic mastocytosis have not noted this association. During cyclical therapy with prednisone and chlorambucil in this case, nephrotic-range proteinuria remitted. Peripheral neuropathy resolved 10 months after discontinuation of therapy. Pathophysiological mechanisms resulting in this clinical presentation may be immunologically mediated.
authors.affiliation: Department of Medicine, University of Missouri Health Sciences Center, Columbia 65212.
authors.forename: S M
authors.initials: SM
authors.lastname: Lal
authors.forename: C S
authors.initials: CS
authors.lastname: Brooks
authors.forename: A M
authors.initials: AM
authors.lastname: Luger
authors.forename: J G
authors.initials: JG
authors.lastname: Davenport
authors.forename: R D
authors.initials: RD
authors.lastname: Weber
authors.forename: T S
authors.initials: TS
authors.lastname: Loy
authors.forename: H H
authors.initials: HH
authors.lastname: Haibach
mesh_terms: D003711:Demyelinating Diseases / Q000150:complications / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D008415:Mastocytosis / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications* / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000150:complications*; D013497:Sural Nerve / Q000473:pathology