Studies on antifungal agents. 18. In vitro activity of 5,5-disubstituted-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methy lisoxazol idines and related compounds.
The in vitro antifungal activity of a series of novel 5,5-disubstituted-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methyli soxazolidines and related compounds against Trichophyton rubrum, Aspergillus fumigatus and Candida albicans was studied. The screening was performed in solid agar cultures and some structure-activity relationships involving the C-5-substitution pattern are discussed.
Mullen
G B
GB
Department of Organic Chemistry, Pennwalt Corporation, Rochester, N.Y.
DeCory
T R
TR
Allen
S D
SD
Mitchell
J T
JT
St Georgiev
V
V
D000368:Aged; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis; D007555:Isoxazoles / Q000138:chemical synthesis; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015363:Quinolones / Q000138:chemical synthesis / Q000494:pharmacology; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D007093:Imidazoles; D007555:Isoxazoles; D015363:Quinolones