Effect of nicardipine on left ventricular function and on angina induced by atrial pacing in patients with coronary artery disease.
The effect of intravenous nicardipine, a new calcium antagonist, on haemodynamics, left ventricular function and angina induced by atrial pacing has been investigated in patients with coronary artery disease. Patients were treated with beta-blockers and measurements were made at a fixed heart rate. Nicardipine produced a 24% fall in mean systemic blood pressure (P less than 0.02) and a 37% increase in cardiac index (P less than 0.02). Cardiac filling pressures, dp/dt max and left ventricular ejection fraction were unaltered. The time to pacing induced angina was prolonged (P less than 0.05) when the dose of nicardipine (0.75 mg X min-1) was selected not to cause an excessive fall in blood pressure. Nicardipine is a powerful arteriodilator without detectable negative inotropic effects and prolongs the time to pacing induced angina.
Lipkin
D P
DP
Poole-Wilson
P A
PA
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002304:Cardiac Pacing, Artificial; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D009529:Nicardipine; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014655:Vascular Resistance / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D009529:Nicardipine; D009543:Nifedipine