Haemodynamic effects of the renin inhibitor SR 42128 in conscious baboons.
We studied the haemodynamic effects of captopril [3 mg/kg intravenously (i.v.)] and SR 42128 (8 mg/kg in a 30-min perfusion) in the conscious baboon after sodium depletion by furosemide. The evolution of the following parameters was studied: plasma renin activity (PRA), heart rate (HR), mean arterial pressure (MAP), cardiac output (CO), first derivative of the left intraventricular pressure (dP/dt) and total peripheral resistance (TPR). Captopril (n = 5) increased PRA twofold and decreased MAP and TPR. Heart rate, CO and dP/dtmax were not significantly modified. As compared with a control group (n = 5), SR 42128 (n = 5) decreased PRA to almost undetectable levels for at least 2 h and decreased MAP, CO and TPR. It did not alter HR or dP/dtmax. Thus we can conclude that SR 42128 is a long-acting inhibitor of circulating renin in baboons and, in our experimental conditions, SR 42128, like captopril, induced a decrease in blood pressure without detrimental effect on cardiac function.
de Claviere
M
M
Sanofi, Centre de Recherches Clin Midy, Montpellier, France.
Fourment
P
P
Richaud
J P
JP
Unkovic
J
J
Gagnol
J P
JP
Mazue
G
G
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology*; D010215:Papio; D012083:Renin / Q000097:blood; D000092502:Renin Inhibitors
D009842:Oligopeptides; D012083:Renin; D000092502:Renin Inhibitors; C046599:SR 42128