Enhanced bioavailability of insulin after rectal administration with enamine as adjuvant in depancreatized dogs.
Rectal absorption of insulin by depancreatized dogs was significantly enhanced by the coadministration of enamine as a suppository adjuvant and if this was followed by a further suppository containing enamine alone, the insulin absorption was even further enhanced. The additional enamine suppository resulted in high serum insulin concentrations for a longer time and effected a significant decrease in serum glucose concentrations. To decrease serum glucose concentrations effectively in depancreatized dogs, serum insulin levels had to remain high for a long period of time, rather than be transient.
Nishihata
T
T
Okamura
Y
Y
Kamada
A
A
Higuchi
T
T
Yagi
T
T
Kawamori
R
R
Shichiri
M
M
D000277:Adjuvants, Pharmaceutic / Q000494:pharmacology*; D000588:Amines / Q000494:pharmacology*; D000818:Animals; D001682:Biological Availability; D004285:Dogs; D007328:Insulin / Q000008:administration & dosage* / Q000378:metabolism; D007408:Intestinal Absorption; D010180:Pancreatectomy; D012007:Rectum / Q000378:metabolism; D013488:Suppositories
D000277:Adjuvants, Pharmaceutic; D000588:Amines; D007328:Insulin; D013488:Suppositories