[Effect of thrombomodulin on specific thrombin functions: fibrinogen coagulation and thrombocyte aggregation].
The effect of thrombomodulin (TM), prepared from rabbit lungs, on fibrinogen clotting and platelets aggregation by alpha-thrombin has been investigated. It has been established that TM caused a dose-dependent decrease in fibrinogen-clotting activity of thrombin (Ki = 14.7 +/- 1.24 nM). TM was shown to reduce thrombin-induced platelet aggregation but not to alter ADP-induced one. It was found that the kinetic parameters for hydrolysis of synthetic substrates by alpha-thrombin were not altered by TM.
Luk'ianenko
E F
EF
Kireeva
E G
EG
Strukova
S M
SM
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005340:Fibrinogen / Q000502:physiology*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D011956:Receptors, Cell Surface / Q000502:physiology*; D018179:Receptors, Thrombin; D013917:Thrombin / Q000502:physiology*
D011956:Receptors, Cell Surface; D018179:Receptors, Thrombin; D000244:Adenosine Diphosphate; D005340:Fibrinogen; D013917:Thrombin
Vliianie trombomodulina na spetsificheskie funktsii trombina: svertyvanie fibrinogena i agregatsiiu trombotsitov.