Bovine viral diarrhoea virus infections in piglets born to sows vaccinated against swine fever with contaminated vaccine.
On eight farms a congenital pestivirus infection in piglets was detected which could be traced to vaccination of the dams against swine fever (SF). Viruses isolated from the piglets were not recognised by monoclonal antibodies (MCAs) against swine fever virus (SFV) and were shown to be bovine viral diarrhoea virus (BVDV) or Border disease virus. The expected 'Chinese' strain of SFV could not be demonstrated in the batch of vaccine that had been used on these farms. Instead, a contaminating pestivirus was recovered which was not recognised by the MCAs against SFV. The contaminant had an unexpectedly high virulence for lambs and induced antibodies against BVDV in lambs and pigs. It could, therefore, be characterised as BVDV or Border disease virus.
Wensvoort
G
G
Central Veterinary Institute, Department of Virology, Lelystad, The Netherlands.
Terpstra
C
C
D000818:Animals; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000209:etiology; D002417:Cattle; D006691:Classical Swine Fever / Q000517:prevention & control*; D003967:Diarrhea / Q000209:etiology / Q000382:microbiology / Q000662:veterinary*; D005260:Female; D013552:Swine; D013553:Swine Diseases / Q000209:etiology / Q000382:microbiology*; D014036:Togaviridae Infections / Q000209:etiology / Q000662:veterinary*; D014765:Viral Vaccines / Q000009:adverse effects*
D014765:Viral Vaccines