Somatostatin and peripheral blood flow in man.
Somatostatin (SS), a physiological substance which inhibits secretion of GH, TSH, glucagon and insulin, was evaluated as a vasoactive agent. In normal and arteriopathic subjects SS was administered intravenously by bolus for 3 minutes and by infusion for 30 minutes. Rheography and plethysmography of lower limbs were performed before, during and after somatostatin administration. A marked improvement of blood flow, provoked by somatostatin, was observed. A reduction of heart rate was also observed. Some hypotheses about the mechanism with which SS acts upon peripheral circulation are discussed.
Savi
L
L
Cardillo
C
C
Bombardieri
G
G
D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D006801:Humans; D008875:Middle Aged; D010991:Plethysmography; D010992:Plethysmography, Impedance; D013004:Somatostatin / Q000008:administration & dosage / Q000502:physiology*; D013997:Time Factors
D013004:Somatostatin