Potentiation of the 5-hydroxytryptamine-induced increases in myocardial contractility in Mercenaria mercenaria ventricle by forskolin.
Forskolin (10(-5) M), an activator of adenylate cyclase in many mammalian cell types, potentiated the positive inotropic effects of 5-hydroxytryptamine (5-HT) on the bivalve, Mercenaria mercenaria, myocardium. Forskolin (10(-5) M) also significantly increased intracellular cyclic AMP concentrations when compared to 5-HT controls. Ro 20-1724 (10(-5) M), a putative inhibitor of cyclic AMP phosphodiesterase, had no effect on myocardial contractility or cyclic AMP concentration. A positive correlation between intracellular cyclic AMP concentration and the efficacy of 5-HT was obtained.
Paciotti
G F
GF
Higgins
W J
WJ
D000818:Animals; D005576:Colforsin; D000242:Cyclic AMP / Q000378:metabolism; D004224:Diterpenes / Q000494:pharmacology*; D004357:Drug Synergism; D008974:Mollusca / Q000502:physiology*; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology*
D004224:Diterpenes; D005576:Colforsin; D012701:Serotonin; D000242:Cyclic AMP