Dihydropyridine-sensitive and insensitive Ca2+ channels in human platelets.
The Ca2+ channel blocker, nifedipine, a dihydropyridine derivative, inhibited the Ca2+ influx and release from internal stores caused by collagen or a low concentration of the thromboxane A2 (TXA2) analogue, 9,11-epithio-11,12-methano-TXA2 (STA2) (10 nM), but did not inhibit those caused by thrombin or a high concentration of STA2 (100 nM). These results indicate the presence of two distinct, dihydropyridine-sensitive and insensitive, Ca2+ channels dependent on the concentrations and classes of agonists in human platelets.
Moriyama
T
T
Research Institute for Food Science, Kyoto University.
Takamura
H
H
Narita
H
H
Tanaka
K
K
Matsuura
T
T
Kito
M
M
D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D015220:Calcium Channels / Q000187:drug effects* / Q000378:metabolism; D003094:Collagen / Q000494:pharmacology; D004110:Diltiazem / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D009543:Nifedipine / Q000494:pharmacology*; D013928:Thromboxane A2 / Q000031:analogs & derivatives / Q000494:pharmacology
D015220:Calcium Channels; D013928:Thromboxane A2; C037866:STA 2; D003094:Collagen; D004110:Diltiazem; D009543:Nifedipine