[Elevated Na+/H+ exchange in erythrocytes of patients with hypertension].
The kinetics of proton efflux from erythrocytes with acidified cytoplasm (pHi 6.4) in a medium with pH 8.0 has been studied. The participation of the anion exchanger in this process was blocked by a stilbene disulfonic acid derivative. It was shown that the rate of Na+/H+ exchange (amiloride-inhibited component of proton efflux) is increased 2 fold. The addition of protein kinase C activator (1 microM of TPA) results in the increase of the rate of Na+/H+ exchange by 4 fold.
Orlov
S N
SN
Postnov
I Iu
IIu
Pokudin
N I
NI
Kukharenko
V Iu
VIu
Postnov Iuv
D000328:Adult; D002352:Carrier Proteins / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011493:Protein Kinase C / Q000097:blood; D011522:Protons; D012964:Sodium / Q000097:blood*; D017923:Sodium-Hydrogen Exchangers
D002352:Carrier Proteins; D011522:Protons; D017923:Sodium-Hydrogen Exchangers; D012964:Sodium; D011493:Protein Kinase C
Uvelichennyĭ Na+/H+-obmen v éritrotsitakh bol'nykh gipertonicheskoĭ bolezn'iu.