The effect of prostaglandins F2 alpha and E2 on the adrenergic activity of the uterus of laying hens (Gallus domesticus) in vitro.
The effect of PGF2 alpha and PGE2 before or after administration of isoproterenol or norepinephrine was studied on uterine strips of White Leghorn laying hens. Prostaglandins (0.2 ng/ml of bath solution) always produced an increase in tension and area under the tracing, the effect of PGF2 alpha being significantly marked especially when administered after norepinephrine. Norepinephrine and isoproterenol (0.1 microgram/ml of bath solution) produced a marked decrease in area under the tracing, the effect of isoproterenol being more potent especially when administered before prostaglandins.
Iturri
S J
SJ
Crossley
J
J
Torres
A
A
D000818:Animals; D002645:Chickens; D015237:Dinoprost; D015232:Dinoprostone; D005260:Female; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000187:drug effects* / Q000502:physiology; D014590:Uterine Contraction / Q000187:drug effects*; D014599:Uterus / Q000294:innervation
D011458:Prostaglandins E; D011460:Prostaglandins F; D011941:Receptors, Adrenergic; D015237:Dinoprost; D015232:Dinoprostone; D007545:Isoproterenol; D009638:Norepinephrine