Co-amplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinoma.
Transforming activity was detected in a hepatocellular carcinoma (HCC) carrying four integrated hepatitis B virus (HBV) DNA. This transforming gene was identified as hst-1, that lies in chromosome 11, band q13.3. One of the integrated HBV DNAs was found to lie close to the hst-1, and the hst-1 and the integrated HBV DNA were found to be co-amplified. The region of the amplification was limited. A model has been proposed that correlates the viral integration, amplification and activation of an oncogene.
Hatada
I
I
Institute for Molecular and Cellular Biology, Osaka University, Japan.
Tokino
T
T
Ochiya
T
T
Matsubara
K
K
D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002471:Cell Transformation, Neoplastic; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D004273:DNA, Neoplasm / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics*; D005784:Gene Amplification; D005814:Genes, Viral; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D009857:Oncogenes
D004273:DNA, Neoplasm; D004279:DNA, Viral