The significance of central nicotine receptors in the aggression of isolated mice.
The effect of nicotine, and some nicotinic antagonists on aggressive behavior of isolated mice was tested. Nicotine in doses of 0.5-2 mg/kg ip and 0.005-0.06 mg/mouse ivtr potentiated the aggressiveness. However, higher doses nicotine (4 mg/kg ip and 0.09 mg/kg (Polfa). Co-suppressed the aggression. Mecamylamine, a central nicotinic antagonist in a dose of 2 mg/kg facilitated the aggression while in doses of 4 and 8 mg/kg inhibited it. Hexamethonium, a peripheral nicotinic antagonist, partially suppressed the aggressive behavior. Our results indicate that central nicotinic receptors have also a certain role in mediating the investigated type of mouse aggression.
Roliński
Z
Z
Herbut
M
M
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D051379:Mice; D009538:Nicotine / Q000494:pharmacology*; D010830:Physostigmine / Q000494:pharmacology; D011978:Receptors, Nicotinic / Q000502:physiology*; D012934:Social Isolation
D006584:Hexamethonium Compounds; D011978:Receptors, Nicotinic; D018738:Hexamethonium; D008464:Mecamylamine; D009538:Nicotine; D010830:Physostigmine