title: Cyclic GMP and protein kinase G inhibit the quantal transmitter release induced by protein kinase C.
abstract: Protein kinase G inhibits the spontaneous release of acetylcholine quanta at the frog neuromuscular junction as shown by the effects of H-8, a G kinase blocking agent. Moreover, the permeant dibutyryl cGMP blocked the frequency increase obtained in the presence of protein kinase C activators (diacylglycerol and phorbol ester) while the cAMP activated protein kinase A did show only an additive effect.
authors.affiliation: Department of Physiology, Institute of Medicine and Pharmacy, Iassy, Romania.
authors.forename: D D
authors.initials: DD
authors.lastname: Brănişteanu
authors.forename: L M
authors.initials: LM
authors.lastname: Popescu
authors.forename: D D
authors.initials: DD
authors.lastname: Brănişteanu
authors.forename: I D
authors.initials: ID
authors.lastname: Haulică
mesh_terms: D000818:Animals; D006152:Cyclic GMP / Q000031:analogs & derivatives*; D003995:Dibutyryl Cyclic GMP / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D066298:In Vitro Techniques; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D011493:Protein Kinase C / Q000494:pharmacology*; D011494:Protein Kinases / Q000494:pharmacology*; D011895:Rana ridibunda; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors
chemical_list: D004791:Enzyme Inhibitors; D003995:Dibutyryl Cyclic GMP; D011494:Protein Kinases; D011493:Protein Kinase C; D006152:Cyclic GMP