[Intensification of neurogenic spasms of the cerebral vessels by naloxone].
Naloxone was shown to induce a slight increase of the blood supply to the brain, an elevation of blood pressure and an enhancement of the bioelectrical activity in the sympathetic nerves. Unlike opioid peptides, naloxone was found to exert a marked alleviating effect on the nervous control of the cerebral circulation. The drug increases neurogenic spasms of the cerebral vessels that is followed by an enhancement of vasomotor and somatosympathetic reflexes. The data obtained indicate the role of the opioid system in the central regulation of the cerebral circulation.
Mirzoian
R S
RS
Gan'shina
T S
TS
Ragimov
Kh S
KhS
D000218:Adamantane / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D000818:Animals; D002415:Cats; D002536:Cerebral Arteries / Q000187:drug effects* / Q000294:innervation; D002550:Cerebral Veins / Q000187:drug effects* / Q000294:innervation; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000503:physiopathology; D004952:Esters / Q000493:pharmacokinetics; D006439:Hemodynamics / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology; D012018:Reflex / Q000187:drug effects / Q000502:physiology; D013035:Spasm / Q000209:etiology / Q000503:physiopathology; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
D004952:Esters; D011957:Receptors, Opioid; D009270:Naloxone; D000218:Adamantane
Usilenie neĭrogennykh spazmov sosudov mozga naloksonom.