title: [Humoral factors of local and systemic immunity in the multiple peroral administration of a corpuscular pertussis vaccine].
abstract: Multiple oral immunization with pertussis corpuscular vaccine was shown to lead to the considerable stimulation of local and systemic humoral immunity. The data on the titers of specific and normal secretory antibodies, on the levels of IgA in washings from the oral cavity, the small intestine and the lungs, on the titers of agglutinins and hemagglutinins in the blood serum, as well as on the morpho-functional transformation of the mucous membrane and the associated lymphoid tissue in the digestive tract, are presented in their dynamics. Specific pertussis antibodies in high titers were detected in both intestinal and pulmonary washings. The multiple administration of the vaccine did not produce pathological changes in internal organs.
authors.forename: N S
authors.initials: NS
authors.lastname: Zakharova
authors.forename: G S
authors.initials: GS
authors.lastname: Vlasov
authors.forename: S N
authors.initials: SN
authors.lastname: Kuz'min
authors.forename: B B
authors.initials: BB
authors.lastname: Pershin
authors.forename: V F
authors.initials: VF
authors.lastname: Salov
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation / Q000187:drug effects; D000918:Antibody Specificity; D001886:Bordetella pertussis / Q000276:immunology; D004064:Digestive System / Q000276:immunology / Q000503:physiopathology; D007114:Immunization; D009055:Mouth / Q000276:immunology / Q000503:physiopathology; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D011817:Rabbits; D012137:Respiratory System / Q000276:immunology / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D010567:Pertussis Vaccine
vernacular_title: Gumoral'nye faktory mestnogo i sistemnogo immuniteta pri mnogokratnom peroral'nom vvedenii korpuskuliarnoĭ kokliushnoĭ vaktsiny.