Relationship between the sympathetic nervous system and sodium potassium adenosine triphosphatase inhibitor in salt-sensitive patients with essential hypertension.
In order to evaluate endogenous Na+,K+-ATPase inhibitor on sympathetic nerve endings, endogenous Na+,K+-ATPase inhibitor and plasma noradrenaline were determined in patients with essential hypertension under different sodium conditions. Compared with the plasma from non-salt-sensitive patients, that from salt-sensitive patients showed significantly higher Na+,K+-ATPase inhibitor and plasma noradrenaline levels. Salt-induced changes in endogenous Na+,K+-ATPase inhibitor and those in blood pressure or plasma noradrenaline showed positive correlations. These results suggest that the salt-induced increase in endogenous Na+,K+-ATPase inhibitor might induce blood pressure elevation in essential hypertension, at least partly via increased noradrenaline levels.
Nishio
I
I
Department of Cardiology, Internal Medicine, Wakayama Medical College, Japan.
Shima
H
H
Tsuda
K
K
Hano
T
T
Masuyama
Y
Y
D001794:Blood Pressure; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D009318:Natriuresis; D009638:Norepinephrine / Q000097:blood; D012964:Sodium / Q000378:metabolism*; D012982:Sodium, Dietary / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D012982:Sodium, Dietary; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D009638:Norepinephrine