Transport and distribution of copper injected into an albumin-deficient (analbuminemic) rat.
Copper (Cu) concentrations in blood, liver, kidney, spleen and pancreas of an albumin-deficient (Nagase analbuminemic) rat (NAR) were compared with those of a control (Sprague-Dawley) rat (SDR). Cu concentrations were significantly higher in the blood and significantly lower in the liver of the NAR strain than those of the SDR strain in female control (saline-injected) groups at 8 weeks old. Female NAR and SDR 8-week-old rats were injected i.p. with Cu at a single dose of 2.0 mg/kg body wt and killed 18 hr later. Concentrations of Cu and other essential elements in the blood, liver, kidney, spleen and pancreas were determined simultaneously by inductively coupled plasma-atomic emission spectrometry. Cu concentration in the liver was significantly lower in the NAR than in the SDR strain suggesting a role for albumin as a carrier protein of free Cu ions in the blood. The effects of Cu loading on other essential elements (Zn, Fe, Ca, Mg, P) were also compared between the NAR and SDR strains.
Suzuki
K T
KT
Ohta
K
K
Sunaga
H
H
Sugihira
N
N
D000818:Animals; D001835:Body Weight; D003300:Copper / Q000097:blood / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D009929:Organ Size; D010179:Pancreas / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D012709:Serum Albumin / Q000172:deficiency*; D013045:Species Specificity; D013154:Spleen / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
D012709:Serum Albumin; D003300:Copper; D015032:Zinc