title: Interpatient variations in antipsychotic therapy.
abstract: There is wide interpatient variability not only in therapeutic response to a given dose of antipsychotic drug but also in steady-state plasma levels and the presence and degree of unwanted pharmacologic effects. Such variations have been attributed to individual metabolism, pharmacologic differences, and age--all of which may need careful consideration in prescribing an appropriate dosage regimen for a given patient.
authors.forename: I M
authors.initials: IM
authors.lastname: McIntyre
authors.forename: S
authors.initials: S
authors.lastname: Gershon
mesh_terms: D000367:Age Factors; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D001480:Basal Ganglia Diseases / Q000139:chemically induced; D002746:Chlorpromazine / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D005476:Fluphenazine / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D001523:Mental Disorders / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D014150:Antipsychotic Agents; D006220:Haloperidol; D005476:Fluphenazine; D002746:Chlorpromazine