Induction of metal-binding proteins by zinc is accompanied by reduction of other proteins including antibodies.
Exposure of carp lymphoid cells to zinc causes formation of metal-binding proteins (metallothioneins). Metallothionein induction is accompanied by a suppression of the production of other proteins. Antibodies are among the proteins which are decreased by zinc exposure. Similar results from in vivo experiments indicate that zinc might affect even fish living in water still regarded as unpolluted.
Cenini
P
P
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D002347:Carps; D002478:Cells, Cultured; D003600:Cytosol / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008668:Metallothionein / Q000096:biosynthesis*; D014176:Protein Biosynthesis; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D015032:Zinc / Q000378:metabolism / Q000494:pharmacology*
D000906:Antibodies; D008668:Metallothionein; D015032:Zinc