title: Primary structure and expression of a functional human glucocorticoid receptor cDNA.
abstract: Identification of complementary DNAs encoding the human glucocorticoid receptor predicts two protein forms, of 777 (alpha) and 742 (beta) amino acids, which differ at their carboxy termini. The proteins contain a cysteine/lysine/arginine-rich region which may define the DNA-binding domain. Pure radiolabelled glucocorticoid receptor, synthesized in vitro, is immunoreactive and possesses intrinsic steroid-binding activity characteristic of the native glucocorticoid receptor.
authors.forename: S M
authors.initials: SM
authors.lastname: Hollenberg
authors.forename: C
authors.initials: C
authors.lastname: Weinberger
authors.forename: E S
authors.initials: ES
authors.lastname: Ong
authors.forename: G
authors.initials: G
authors.lastname: Cerelli
authors.forename: A
authors.initials: A
authors.lastname: Oro
authors.forename: R
authors.initials: R
authors.lastname: Lebo
authors.forename: E B
authors.initials: EB
authors.lastname: Thompson
authors.forename: M G
authors.initials: MG
authors.lastname: Rosenfeld
authors.forename: R M
authors.initials: RM
authors.lastname: Evans
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000032:analysis*; D004591:Electrophoresis, Polyacrylamide Gel; D005786:Gene Expression Regulation; D006801:Humans; D046911:Macromolecular Substances; D011061:Poly A / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis; D011965:Receptors, Glucocorticoid / Q000235:genetics*
chemical_list: D046911:Macromolecular Substances; D012333:RNA, Messenger; D011965:Receptors, Glucocorticoid; D011061:Poly A; D004247:DNA