Pyridoxamine as inhibitor of the blood plasma benzylamine oxidase and other copper-containing amine oxidases.
Pyridoxamine inhibits rabbit and pig plasma benzylamine oxidase (BAO), the diamine oxidase of pig kidney and the lysyloxidase of pig aorta in-vitro. In-vivo in the rabbit, the inhibitory activity of pyridoxamine on plasma BAO is antagonized by an increase in the level of this enzyme that is dependent on an increase in rate of synthesis, there being no variation in the degradation rate constant.
Buffoni
F
F
Banchelli
G
G
Dolara
P
P
Ignesti
G
G
Pirisino
R
R
Raimondi
L
L
Ziche
M
M
D000818:Animals; D001595:Benzylamine Oxidase / Q000037:antagonists & inhibitors* / Q000097:blood; D001711:Biotransformation; D003300:Copper; D006207:Half-Life; D066298:In Vitro Techniques; D008995:Monoamine Oxidase; D008996:Monoamine Oxidase Inhibitors; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000037:antagonists & inhibitors* / Q000097:blood; D011732:Pyridoxal Phosphate / Q000494:pharmacology; D011733:Pyridoxamine / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits; D012663:Semicarbazides / Q000494:pharmacology; D013552:Swine; D013997:Time Factors
D008996:Monoamine Oxidase Inhibitors; D012663:Semicarbazides; D011732:Pyridoxal Phosphate; D011733:Pyridoxamine; D003300:Copper; D001595:Benzylamine Oxidase; D008995:Monoamine Oxidase; D000587:Oxidoreductases Acting on CH-NH Group Donors