[Behavior disorder in rats induced by Madopar and its pharmacological correction].
Administration to rats of madopar in a dose of 125 mg/kg produced stereotypy, decrease in the exploration activity in the open field test, loss of the ability to decide the extrapolation problem (escape out of acute stressful situation). The latter type of behavioral pathology alone was selectively averted by administering the classical neuroleptics fluorophenazine, haloperidol and its analog azaperone. Atypical neuroleptics and the the antidepressant imipramine were less effective and reduced but animals' motor excitation induced by madopar according to the extrapolation avoidance test. The tranquilizer phenazepam did not influence behavioral pathology in this test. The data obtained suggest that impairment of the animals' behavioral pattern in the extrapolation avoidance test on madopar administration in a dose of 125 mg/kg may serve an experimental model for evaluating the neuroleptic effect of the drugs.
Bondarenko
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Bondarenko
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D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects*; D001545:Benserazide / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D006834:Hydrazines / Q000494:pharmacology*; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D011619:Psychotropic Drugs / Q000627:therapeutic use; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects
D014150:Antipsychotic Agents; D004338:Drug Combinations; D006834:Hydrazines; D011619:Psychotropic Drugs; C005177:benserazide, levodopa drug combination; D007980:Levodopa; D001545:Benserazide
Narushenie povedeniia krys, vyzvannoe madoparom i ego farmakologicheskaia korrektsiia.