title: Cyclic AMP and cyclic GMP in hyperresponsiveness.
abstract: Cyclic-AMP has been shown to cause a hyperresponse in blood pressure change in conjunction with norepinephrine in the anesthetized rat system. Recent experiments show that the antagonist to angiotensin II, Sar1-Thr8 angiotensin II, abolishes the hyperresponse produced by c-AMP. This is interpreted to mean that the added response caused by c-AMP is mediated through angiotensin II. When the antagonist is removed, the hyperresponse is observed to return. The experiments with cyclic-GMP indicate that the hyperresponse seen with c-AMP is not only absent, but a constant decrease in response to norepinephrine is observed as long as c-GMP is present. The decrease in blood pressure change in the presence of c-GMP suggests that the 10-5M c-GMP causes a relaxation of vascular smooth muscle. These two cyclic nucleotides seem to produce their effects by two completely different mechanisms.
authors.affiliation: Department of Natural Sciences and Mathematics, Lincoln University, Jefferson City, Missouri 65101.
authors.forename: H T
authors.initials: HT
authors.lastname: Miller
authors.forename: W
authors.initials: W
authors.lastname: Yesus
authors.forename: T
authors.initials: T
authors.lastname: Cooper
authors.forename: S
authors.initials: S
authors.lastname: Harwell
mesh_terms: D000804:Angiotensin II / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D000242:Cyclic AMP / Q000494:pharmacology*; D006152:Cyclic GMP / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D012016:Reference Values
chemical_list: D000804:Angiotensin II; C014805:angiotensin II, Sar(1)-Thr(8)-; D000242:Cyclic AMP; D006152:Cyclic GMP; D009638:Norepinephrine