title: Induction of calcium influx in immature T lymphocytes by anti-FT-1 monoclonal antibody.
abstract: The functional role of FT-1 antigen was investigated by measuring changes in intracellular [Ca2+]i after the addition of anti-FT-1 monoclonal antibody to murine T leukemic cells and embryonic thymocytes. Anti-FT-1 induced a rapid and sustained increase in cytosolic free [Ca2+]i and this effect was completely blocked by EGTA and La3+. These results suggest that FT-1 molecule is functionally associated with a plasma membrane calcium ion channel in embryonic thymocytes.
authors.affiliation: Department of Cellular Immunology, National Institute of Health, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kasai
authors.forename: T
authors.initials: T
authors.lastname: Kataoka
authors.forename: T
authors.initials: T
authors.lastname: Tokunaga
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000941:Antigens; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D002454:Cell Differentiation; D004533:Egtazic Acid / Q000494:pharmacology; D005333:Fetus / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D007811:Lanthanum / Q000494:pharmacology; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D000941:Antigens; D015220:Calcium Channels; D004533:Egtazic Acid; D007811:Lanthanum; D002118:Calcium