The selectivity of the reduction of serotonin S2 receptors in Alzheimer-type dementia.
The high-affinity binding of thirteen ligands to putative neurotransmitter receptors was studied in temporal cortex of control and Alzheimer-type dementia (ATD) patients. A selective reduction of serotonin S2 receptors was observed in the ATD patients, to 57% of controls with no change in S1 receptors. Of the other ligand binding sites studied, only 3H-flunitrazepam binding was significantly reduced, to 84% of controls. Ligand binding sites which were unchanged in ATD temporal cortex included those labelled by adrenergic, adenosine, histamine, opiate, GABA, benzodiazepine and cholinergic ligands.
Cross
A J
AJ
Crow
T J
TJ
Ferrier
I N
IN
Johnson
J A
JA
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D002540:Cerebral Cortex / Q000032:analysis; D005260:Female; D006801:Humans; D008024:Ligands; D008297:Male; D011180:Postmortem Changes; D011963:Receptors, GABA-A / Q000032:analysis; D011985:Receptors, Serotonin / Q000032:analysis*; D013004:Somatostatin / Q000032:analysis; D013702:Temporal Lobe / Q000032:analysis*
D008024:Ligands; D011963:Receptors, GABA-A; D011985:Receptors, Serotonin; D013004:Somatostatin