title: beta-Adrenoceptor blocking agents recognize a subpopulation of serotonin receptors in brain.
abstract: The interaction of beta-adrenoceptor blocking agents with serotonin receptors in rat brain was analyzed by quantitative light microscopic autoradiography using (-) [125I]cyanopindolol (ICYP) as a ligand. In some brain areas such as the globus pallidus and dorsal subiculum, binding of ICYP was blocked with high affinity by some serotoninergic ligands, RU-24969 and serotonin, but not by lysergic acid diethylamide and 8-hydroxy-2-(N,N-di-n-propylamino)tetralin. Some beta-blockers also showed high affinity for these sites. These results supply direct evidence for the labeling of a subclass of serotonin receptors, the 5-HT-1B class, providing anatomical and pharmacological basis for some known serotonin-related effects of beta-adrenoceptor drugs.
authors.forename: A
authors.initials: A
authors.lastname: Pazos
authors.forename: G
authors.initials: G
authors.lastname: Engel
authors.forename: J M
authors.initials: JM
authors.lastname: Palacios
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping; D020120:Iodocyanopindolol; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism*
chemical_list: D000319:Adrenergic beta-Antagonists; D011985:Receptors, Serotonin; D020120:Iodocyanopindolol; D010869:Pindolol