[The preparation and histaminergic properties of 2-(2-oxo-4-imidazolin-4-yl)ethylamine].
Carrying on the study of the effects induced by substitution at position 2- of histamine imidazole ring, this article briefly reports the synthesis of 2-(2-oxo-4-imidazolin-4-yl)ethylamine. The pharmacological properties of this compound and its sulphurated analogue 2-(2-thiono-4-imidazolin-4-yl)ethylamine, showed that the marked structural modification of the critical moieties involved in the binding at the H1- and H2-receptors resulted in a loss of histamine-like activity.
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D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005750:Gastric Juice / Q000378:metabolism; D006168:Guinea Pigs; D006632:Histamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006633:Histamine Antagonists / Q000138:chemical synthesis*; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis; D006635:Histamine H2 Antagonists / Q000138:chemical synthesis
D006633:Histamine Antagonists; D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; C045725:2-(2-oxo-4-imidazolin-4-yl)ethylamine; D006632:Histamine
Sulla preparazione e proprietà istaminergiche della 2-(2-osso-4-imidazolin-4-il)etilamina.