Increased proportion of proapolipoprotein A-I in HDL from patients with liver cirrhosis and hepatitis.
We examined the isoform pattern of apolipoprotein A-I (apo A-I) in high density lipoprotein from patients with liver disease. An increase in the proportion of proapo A-I was evident in patients with decompensated liver cirrhosis, acute hepatitis and hepatocellular carcinoma. The rate of conversion from proapo A-I to apo A-I was low in sera from those with liver disease, compared to normal controls. The proportion of proapo A-I showed a tendency toward increase with advance in liver damage. These results suggest that the liver is participating in the reaction converting proapo A-I to the mature apo A-I.
Matsuura
T
T
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Koga
S
S
Ibayashi
H
H
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D004586:Electrophoresis; D006505:Hepatitis / Q000378:metabolism*; D006801:Humans; D007525:Isoelectric Focusing; D008075:Lipoproteins, HDL / Q000032:analysis*; D008103:Liver Cirrhosis / Q000378:metabolism*; D008113:Liver Neoplasms / Q000378:metabolism*; D011498:Protein Precursors / Q000032:analysis*
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D008075:Lipoproteins, HDL; D011498:Protein Precursors