title: [Antigenic structure of the foot-and-mouth disease virus. II. Synthesis of protective peptides from the major immunogenic region of VP1 protein of foot-and-mouth disease virus type A22].
abstract: Earlier we found that the immune response and antiviral protection from FMDV can be achieved by immunization with uncoupled FMDV peptides. In a search of approaches to animal protection from FMDV A22 strain we prepared a series of peptides corresponding to the putative antigenic determinants. Synthetic 131-149 and 140-149 sequences afforded 50 to 80% protection, both in the free state and conjugated with keyhole limpet hemocyanin. We believe that the 140-149 segment is so far the smallest peptide capable of eliciting specific antiviral protection without conjugation with a high molecular carrier.
authors.forename: O M
authors.initials: OM
authors.lastname: Vol'pina
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Surovoĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Ul'iashin
authors.forename: V T
authors.initials: VT
authors.lastname: Ivanov
authors.forename: A V
authors.initials: AV
authors.lastname: Chepurkin
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D005537:Aphthovirus / Q000276:immunology*; D002851:Chromatography, High Pressure Liquid; D005536:Foot-and-Mouth Disease / Q000517:prevention & control; D006168:Guinea Pigs; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology*; D014764:Viral Proteins / Q000138:chemical synthesis / Q000276:immunology*; D015678:Viral Structural Proteins; D014765:Viral Vaccines
chemical_list: D000956:Antigens, Viral; D010455:Peptides; D014764:Viral Proteins; D015678:Viral Structural Proteins; D014765:Viral Vaccines
vernacular_title: Antigennaia struktura virusa iashchura. II. Sintez protektivnykh peptidov posledovatel'nosti osnovnogo immunogennogo raĭona belka VP1 virusa iashchura shtamma A22.