title: Role of the area postrema in three putative measures of motion sickness in the rat.
abstract: After thermal cauterization of the area postrema in rats the absence of conditioned taste aversion to sucrose paired with lithium chloride (0.15 M, 3.3 ml/kg) was used as a pharmacologic/behavioral index of area postrema damage. In a subsequent experiment the effects of area postrema lesions on three measures proposed as species-relevant measures of motion sickness were studied, using off-vertical rotation at 150 degrees/s for either 30 or 90 min. Lesions of area postrema did not alter postrotational suppression of drinking or amount of defecation during motion. The initial acquisition of conditioned taste aversion to a novel cider vinegar solution paired with motion was not affected by lesioning of the area postrema, but these taste aversions extinguished more slowly in lesioned rats than in sham-operates or intact controls. Results are discussed in terms of proposed humoral factors which may induce motion sickness and in light of recent data on the role of the area postrema in similar measures in species possessing the complete emetic reflex.
authors.affiliation: Department of Psychology, San Jose State University, California 95192.
authors.forename: R L
authors.initials: RL
authors.lastname: Sutton
authors.forename: R A
authors.initials: RA
authors.lastname: Fox
authors.forename: N G
authors.initials: NG
authors.lastname: Daunton
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology; D001362:Avoidance Learning / Q000502:physiology; D001931:Brain Mapping; D002712:Chlorides / Q000633:toxicity; D003214:Conditioning, Classical / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000502:physiology; D007699:Kinesthesis / Q000502:physiology; D008094:Lithium / Q000633:toxicity; D018021:Lithium Chloride; D009041:Motion Sickness / Q000503:physiopathology*; D010286:Paraventricular Hypothalamic Nucleus / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000502:physiology
chemical_list: D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride