Naloxone antagonises effect of alpha-gliadin on leucocyte migration in patients with coeliac disease.
The effect of naloxone on inhibition of leucocyte migration by alpha-gliadin was examined in 24 patients with coeliac disease. In all cases in which alpha-gliadin inhibited leucocyte migration, naloxone blocked this inhibitory effect, which suggests that the effect of gliadin on lymphocytes from patients with coeliac disease may be mediated through opioid-like receptors.
Horváth
K
K
Gráf
L
L
Walcz
E
E
Bodánszky
H
H
Schuler
D
D
D002446:Celiac Disease / Q000276:immunology*; D002464:Cell Migration Inhibition; D002648:Child; D002675:Child, Preschool; D005260:Female; D005903:Gliadin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006801:Humans; D007223:Infant; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology*; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology*; D010940:Plant Proteins / Q000037:antagonists & inhibitors*; D011957:Receptors, Opioid / Q000187:drug effects
D010940:Plant Proteins; D011957:Receptors, Opioid; D009270:Naloxone; D009020:Morphine; D005903:Gliadin