[Acid-stable and acid-labile interferons inducible by the bovine infectious rhinotracheitis virus].
Attenuated and virulent strains of cattle infectious rhinotracheitis virus (IRTV) induced in cattle leukocytes the production of both acid-stable and acid-labile interferon. The attenuated IRTV strain induced the production of the acid-labile interferon in spleen and bone marrow cells of BALB/C mice. The indication of the assignment of the acid-labile interferon to the leukocyte-type of interferon consists in the activity of bovine interferon in a heterologous culture of human diploid fibroblasts and a higher interferon titer in bone marrow than in spleen cells (bone marrow cells contain B-cells which produce leukocyte interferon).
Orlova
T G
TG
Shcheglovitova
O N
ON
Shuliak
A F
AF
Kriukov
N N
NN
D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D002417:Cattle; D002478:Cells, Cultured; D007242:Herpesvirus 1, Bovine / Q000472:pathogenicity*; D006801:Humans; D006851:Hydrochloric Acid / Q000494:pharmacology; D007370:Interferon Type I / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification; D007962:Leukocytes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D011420:Propiolactone / Q000494:pharmacology; D013154:Spleen / Q000276:immunology; D014775:Virus Activation / Q000187:drug effects
D007370:Interferon Type I; D011420:Propiolactone; D006851:Hydrochloric Acid
Kislotostabil'nyĭ i kislotolabil'nyĭ interferony, indutsiruemye virusom infektsionnogo rinotrakheita krupnogo rogatogo skota.