title: Effects of somatostatin-14 and somatostatin-28 on plasma hormonal and gastric secretory responses to cephalic and gastrointestinal stimulation in man.
abstract: This study was designed to determine the influence of cephalic and gastrointestinal meal stimulation on plasma levels of somatostatin-like immunoreactivity (SLI) and to compare plasma hormonal and gastric secretory effects of somatostatin-14 (SS-14) and its putative prohormone, somatostatin-28 (SS-28), in humans. Cephalic stimulation induced by modified sham feeding did not affect plasma SLI, whereas a gastric liver extract meal caused a significant increase in SLI. Infusion of SS-28 dose-dependently suppressed gastric acid, serum gastrin, and plasma pancreatic polypeptide (PP) responses to cephalic and gastrointestinal stimulation. SS-28 was equipotent with SS-14 as gastric inhibitor when compared on the basis of molar doses infused but was 4-10 times less potent on the basis of plasma SLI concentrations obtained. A lower and more physiological dose of SS-14 (75 pmol/kg-h) reduced gastric acid and PP responses but failed to affect the serum gastrin response to a meal; whereas a larger, pharmacological dose (500 pmol/kg-h) also suppressed serum gastrin responses. We conclude that meal releases SLI into the circulation and that SS-28 mimics the gastric secretory and plasma hormonal effects of SS-14 but is several times less potent than SS-14 in terms of circulating hormone levels.
authors.forename: S J
authors.initials: SJ
authors.lastname: Konturek
authors.forename: N
authors.initials: N
authors.lastname: Kwiecień
authors.forename: W
authors.initials: W
authors.lastname: Obtułowicz
authors.forename: W
authors.initials: W
authors.lastname: Bielański
authors.forename: J
authors.initials: J
authors.lastname: Oleksy
authors.forename: A V
authors.initials: AV
authors.lastname: Schally
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D005502:Food; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006801:Humans; D008099:Liver; D008297:Male; D010191:Pancreatic Polypeptide / Q000097:blood; D010434:Pepsin A / Q000378:metabolism; D010455:Peptides / Q000097:blood*; D011863:Radioimmunoassay; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*; D053561:Somatostatin-28
chemical_list: D005755:Gastrins; D010455:Peptides; C029993:somatostatin-like peptides; D013004:Somatostatin; D010191:Pancreatic Polypeptide; D053561:Somatostatin-28; D010434:Pepsin A