title: Field trial of oral cholera vaccines in Bangladesh.
abstract: The protective efficacy of oral B subunit killed whole-cell (BS-WC) and killed whole-cell (WC) cholera vaccines was assessed in 63 498 Bangladeshi children aged 2-15 years and women aged over 15 years. Each received three doses of BS-WC, WC, or placebo in a randomised, double-blinded fashion. Surveillance for cases seeking medical care up to six months after the third dose revealed 26 cases of confirmed cholera in the placebo group, 4 cases in the BS-WC group (protective efficacy 85%; p less than 0.0001), and 11 cases in the WC group (protective efficacy 58%; p less than 0.01). For each vaccine protective efficacy was consistent in different age-groups (2-10 years versus greater than 10 years) and for different severities of cholera.
authors.forename: J D
authors.initials: JD
authors.lastname: Clemens
authors.forename: D A
authors.initials: DA
authors.lastname: Sack
authors.forename: J R
authors.initials: JR
authors.lastname: Harris
authors.forename: J
authors.initials: J
authors.lastname: Chakraborty
authors.forename: M R
authors.initials: MR
authors.lastname: Khan
authors.forename: B F
authors.initials: BF
authors.lastname: Stanton
authors.forename: B A
authors.initials: BA
authors.lastname: Kay
authors.forename: M U
authors.initials: MU
authors.lastname: Khan
authors.forename: M
authors.initials: M
authors.lastname: Yunus
authors.forename: W
authors.initials: W
authors.lastname: Atkinson
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001459:Bangladesh; D002648:Child; D002675:Child, Preschool; D002771:Cholera / Q000517:prevention & control*; D022121:Cholera Vaccines / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D011897:Random Allocation; D014611:Vaccination
chemical_list: D022121:Cholera Vaccines