[Serologic and clinical study of post-transfusion viral contamination after cardiac surgery. Excluding human immunodeficiency virus].
The incidence of post-transfusion viral contamination after cardiac surgery is variable but not negligible. The serological and clinical features of such contamination were determined in a series of 100 consecutive patients seen between June, 1983 and January, 1984. The ELISA technique was used for hepatitis A and B viruses and cytomegalovirus on three samples of blood taken before (S1), and 15 days (S2) and 2 to 3 months (S3) after surgery. In case of hepatitis further investigations were performed for heterophilic infectious mononucleosis antibodies and for hepatitis B virus DNA. The transient appearance at S2 of anti-cytomegalovirus antibodies brought by transfusion was observed in 40% of the cases; seroconversion occurred in 4% (cytomegalovirus 3, hepatitis B virus 1), and 5% of the patients developed clinical and biochemical hepatitis without serological markers.
Petitjean
J
J
Laboratoire de virologie, CHU de Caen.
Khayat
M C
MC
Laforet
F
F
Quibriac
M
M
Freymuth
F
F
Khayat
A
A
Evrard
C
C
Thomas
M
M
D000914:Antibodies, Viral / Q000032:analysis; D006348:Cardiac Surgical Procedures; D003586:Cytomegalovirus Infections / Q000209:etiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005112:Extracorporeal Circulation / Q000009:adverse effects*; D005260:Female; D006506:Hepatitis A / Q000209:etiology*; D006509:Hepatitis B / Q000209:etiology*; D006801:Humans; D008297:Male; D012307:Risk Factors; D065227:Transfusion Reaction
D000914:Antibodies, Viral
Etude sérologique et clinique des contaminations virales post-transfusionnelles après chirurgie cardiaque. En dehors du virus d'immunodéficience humaine.