Central nervous system actions of somatostatin-related peptides.
Somatostatin-related peptides act within the central nervous system to influence adrenomedullary epinephrine secretion and thermoregulation. Cysteamine-induced depletion of brain somatostatin-related peptides or central administration of a somatostatin receptor antagonist alters adrenomedullary epinephrine secretion and thermoregulation in a predictable manner. The actions of cysteamine and the somatostatin receptor antagonist are reversed by administration of somatostatins into the central nervous system, supporting the hypothesis that endogenous brain somatostatin-related peptides are involved in the regulation of adrenomedullary epinephrine secretion and thermoregulation.
Brown
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Fisher
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D000313:Adrenal Medulla / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001833:Body Temperature Regulation / Q000187:drug effects*; D003543:Cysteamine / Q000494:pharmacology; D004837:Epinephrine / Q000097:blood* / Q000378:metabolism; D051379:Mice; D008820:Mice, Obese / Q000502:physiology; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects; D017481:Receptors, Somatostatin; D012636:Secretory Rate / Q000187:drug effects; D013004:Somatostatin / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D001786:Blood Glucose; D011956:Receptors, Cell Surface; D017481:Receptors, Somatostatin; D013004:Somatostatin; D003543:Cysteamine; D004837:Epinephrine