Role of the senile plaque in neuropeptide deficits of Alzheimer's disease.
Senile plaques participate in a cropping of the dendritic tree of enkephalinergic dentate granule cells and hl and subicular pyramidal cells. Somatostatin-containing pyramidal neurons are lost in Alzheimer's disease, whereas nonpyramidal somatostatin neurons are less affected. Fibers containing somatostatin penetrate immature, but not end-stage senile plaques. The senile plaque may precipitate much of the hippocampal denervation seen in Alzheimer's disease.
Kulmala
H K
HK
Hutton
J T
JT
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D004745:Enkephalins / Q000378:metabolism; D006801:Humans; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism
D004745:Enkephalins; D009419:Nerve Tissue Proteins; D013004:Somatostatin