title: Tumorigenic potential of a myc-containing strain of feline leukemia virus in vivo in domestic cats.
abstract: The oncogenic capacity of a myc-containing strain of feline leukemia virus (FeLV), termed LC-FeLV, has been examined after inoculation of the virus into neonatal kittens. Like other myc-containing strains of FeLV, LC-FeLV may induce with relatively short latency, but does not necessarily induce, thymic lymphosarcoma in viremic animals. Naturally occurring and experimentally induced tumors are T-cell lymphomas which contain clonally integrated LC-FeLV proviral DNA and which cannot readily be cultivated in vitro in the presence or absence of exogenously supplied interleukin-2. Acquisition of myc by FeLV decreases the period of latency before the appearance of tumors but does not expand the spectrum of tumors induced by FeLV alone.
authors.affiliation: Department of Microbiology and Immunology, Tulane Medical Center, New Orleans, Louisiana 70112.
authors.forename: L S
authors.initials: LS
authors.lastname: Levy
authors.forename: R E
authors.initials: RE
authors.lastname: Fish
authors.forename: G B
authors.initials: GB
authors.lastname: Baskin
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D015139:Blotting, Southern; D002371:Cat Diseases / Q000209:etiology*; D002415:Cats; D004279:DNA, Viral / Q000032:analysis; D005256:Leukemia Virus, Feline / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000662:veterinary*; D016274:Oncogene Protein p55(v-myc); D011533:Proviruses / Q000235:genetics; D012191:Retroviridae Proteins / Q000235:genetics*; D013601:T-Lymphocytes; D013953:Thymus Neoplasms / Q000209:etiology / Q000662:veterinary*; D014766:Viremia / Q000662:veterinary
chemical_list: D004279:DNA, Viral; D016274:Oncogene Protein p55(v-myc); D012191:Retroviridae Proteins