title: Taxol effects on glia in organotypic mouse spinal cord-DRG cultures.
abstract: Exposure of organotypic mouse spinal cord-dorsal root ganglion cultures to 1-2 microM taxol for up to 6 days results in a remarkable increase in cytoplasmic microtubules in differentiated oligodendroglia. In contrast, there is a notably smaller change in the microtubule complement of astroglia. This suggests that the regulatory and/or synthetic systems for tubulin in these glial types may differ, and that oligodendroglia appear more responsive to modulation in the levels of tubulin subunits as a result of the action of taxol.
authors.forename: E B
authors.initials: EB
authors.lastname: Masurovsky
authors.forename: E R
authors.initials: ER
authors.lastname: Peterson
authors.forename: S M
authors.initials: SM
authors.lastname: Crain
authors.forename: S B
authors.initials: SB
authors.lastname: Horwitz
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001253:Astrocytes / Q000648:ultrastructure; D005727:Ganglia, Spinal / Q000187:drug effects* / Q000648:ultrastructure; D051379:Mice; D008870:Microtubules / Q000648:ultrastructure; D009457:Neuroglia / Q000187:drug effects* / Q000648:ultrastructure; D009924:Organ Culture Techniques; D017239:Paclitaxel; D013116:Spinal Cord / Q000187:drug effects* / Q000648:ultrastructure; D013997:Time Factors
chemical_list: D000470:Alkaloids; D017239:Paclitaxel