[Effect of blockaders of biogenic amine receptors on experimental ulcer development].
The effects of serotonin antagonist peritol, cholinolytic atropine, H2-receptor blocker cimetidine and dopaminergic receptor blocker metoclopramide on stress- and exogenous serotonin-induced gastric ulcerogenesis in rats were studied. Peritol was shown to inhibit significantly serotonin- an stress-induced hemorrhagic effect. Similar but less pronounced inhibit produced by metoclopramide and cimetidine. Atropine decreased gastric hemorrhages induced by serotonin but failed to affect stress-induced hemorrhagic lesions. All antagonists tested decreased stress-induced erosions. Erosive lesions stimulated by exogenous serotonin were significantly decreased by atropine only. Metoclopramide known for its cholinomimetic action increased serotonin-induced erosions. It was concluded that serotonin plays an essential role in the pathogenesis of gastric lesions, and its effects suggest the involvement of acetylcholine, histamine and dopamine.
Karevina
T G
TG
Shevchuk
I M
IM
D000818:Animals; D001285:Atropine / Q000627:therapeutic use; D001679:Biogenic Amines / Q000037:antagonists & inhibitors*; D002927:Cimetidine / Q000627:therapeutic use; D003533:Cyproheptadine / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005753:Gastric Mucosa / Q000187:drug effects; D008787:Metoclopramide / Q000627:therapeutic use; D010438:Peptic Ulcer Hemorrhage / Q000209:etiology / Q000517:prevention & control; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects*; D012701:Serotonin / Q000633:toxicity; D013276:Stomach Ulcer / Q000150:complications / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications
D001679:Biogenic Amines; D011956:Receptors, Cell Surface; D003533:Cyproheptadine; D012701:Serotonin; D001285:Atropine; D002927:Cimetidine; D008787:Metoclopramide
Vliianie blokatorov retseptorov biogennykh aminov na éksperimental'nyĭ ul'tserogenez.