Quinone derivatives lower blood and liver acetaldehyde but not ethanol concentrations following ethanol loading to rats.
A rise in blood and liver acetaldehyde concentrations following an intragastric administration of ethanol to rats was significantly inhibited when the quinone derivatives 2,3-dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone (ubidecarenone, coenzyme Q10), 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid (pyrroloquinoline quinone, PQQ) and 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) were injected intraperitoneally, prior to ethanol load, at a dose of 10, 11.5 and 30 mg/kg of body weight, respectively. When acetaldehyde was incubated in vitro with 1,4-benzoquinone (3.7-13.0 mM) or PQQ (1.4-4.9 mM) at 0 and 40 degrees C, the acetaldehyde concentrations slowly decreased with incubation time at 40 degrees C. The results suggest that low acetaldehyde concentrations following ethanol load are due to an accelerated oxidation of acetaldehyde by PQQ in the liver and the circulating blood.
Hobara
N
N
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
Watanabe
A
A
Kobayashi
M
M
Tsuji
T
T
Gomita
Y
Y
Araki
Y
Y
D000079:Acetaldehyde / Q000097:blood / Q000378:metabolism*; D000818:Animals; D016227:Benzoquinones; D003067:Coenzymes; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D045542:PQQ Cofactor; D015363:Quinolones / Q000378:metabolism / Q000494:pharmacology; D011809:Quinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000494:pharmacology
D016227:Benzoquinones; D003067:Coenzymes; D015363:Quinolones; D011809:Quinones; D014451:Ubiquinone; D000431:Ethanol; D045542:PQQ Cofactor; C024989:coenzyme Q10; D000079:Acetaldehyde; C036619:idebenone