[Chemistry and pharmacology of pyran derivatives. 16. Derivatives of 2-(dialkylamino)-7-methoxychromone with antiallergic activity].
Since 2-(diethylamino)-7-methoxychromone (III a) showed remarkable activity in the rat PCA test, some modifications to its structure were made. For instance new substituents such as chlorine or nitro group were introduced into the molecule and the diethylamino group modified. Thus, 2-(ethylamino)-7-methoxychromone (IX) was prepared by treating 3-methoxyphenol with N-ethylethoxycarbonylacetamide in the presence of phosphorus oxychloride. In this case a small amount of 4-chloro-7-methoxycoumarin was also isolated from the reaction mixture. Moreover compounds (XIV), (XV), (XVII) structurally related to sodium cromoglycate were prepared. The pharmacological screening of some compounds showed a useful antiallergic activity.
Mazzei
M
M
Balbi
A
A
Ermili
A
A
Sottofattori
E
E
Roma
G
G
Schiantarelli
P
P
Cadel
S
S
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002867:Chromones / Q000138:chemical synthesis* / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis*; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D002867:Chromones; D006634:Histamine H1 Antagonists
Ricerche chimiche e farmacologiche su derivati piranici. Nota XVI. Derivati del 2-(dialchilammino)-7-metossicromone ad attività antiallergica.