Effects of neuroleptic drugs on brain beta-endorphin immunoreactivity.
The effect of chronic haloperidol on brain beta-endorphin immunoreactivity was examined in rats. Chronic haloperidol resulted in significant reductions of beta-endorphin immunoreactivity within the striatum, but other brain regions were uneffected. When a variety of neuroleptic drugs were tested, fluphenazine, chlorpromazine and haloperidol resulted in comparable reductions in beta-endorphin immunoreactivity in the striatum. These findings suggest a functional interaction between beta-endorphin and dopamine systems in the striatum.
Beal
M F
MF
Fisher
J
J
Carr
D B
DB
Martin
J B
JB
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D003342:Corpus Striatum / Q000032:analysis; D004298:Dopamine / Q000378:metabolism; D004723:Endorphins / Q000378:metabolism*; D005476:Fluphenazine / Q000031:analogs & derivatives / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008032:Limbic System / Q000032:analysis; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin
D014150:Antipsychotic Agents; D004723:Endorphins; D001615:beta-Endorphin; C011825:fluphenazine depot; D006220:Haloperidol; D005476:Fluphenazine; D002746:Chlorpromazine; D004298:Dopamine