What can be learned from the effects of benzodiazepines on exploratory behavior?
The purpose of this review is to assess the value of using tests of exploratory behavior to study the actions of benzodiazepines. The methods of measuring exploration and the factors influencing it are briefly described. The effects of benzodiazepines on exploratory behavior of rats and mice are reviewed; and the dangers of interpreting the results of such tests in terms of any of the clinical effects of the benzodiazepines is stressed. Finally, the interactions between benzodiazepines and other drugs acting at the GABA-benzodiazepine receptor complex are described. The results of these experiments caution against global classification of compounds as benzodiazepine "antagonists."
File
S E
SE
D000818:Animals; D014151:Anti-Anxiety Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology; D002243:Carbolines / Q000494:pharmacology; D004777:Environment; D005106:Exploratory Behavior / Q000187:drug effects*; D005442:Flumazenil; D008140:Lorazepam / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D002243:Carbolines; D011720:Pyrazoles; D011963:Receptors, GABA-A; D005442:Flumazenil; C024915:beta-carboline-3-carboxylic acid ethyl ester; C028585:propyl beta-carboline-3-carboxylate; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one; D008140:Lorazepam