Vecuronium and atracurium in the elderly: a clinical comparison with pancuronium.
The intubating conditions, time to complete block and duration of clinical relaxation were observed in a group of 101 elderly patients (aged over 65 years) following pancuronium 0.1 mg kg-1, vecuronium 0.1 mg kg-1 or atracurium 0.5 mg kg-1. The intubating conditions in the three groups were similar when assessed at 2 min following relaxant administration. The time to complete block was shortest with vecuronium (4.3 min) in comparison to atracurium (5.0 min) and pancuronium (6.0 min), but the differences were not statistically significant. The duration of clinical relaxation, however, was significantly shorter with vecuronium (37 min) and atracurium (35 min) in comparison to pancuronium (99 min).
Lowry
K G
KG
Mirakhur
R K
RK
Lavery
G G
GG
Clarke
R S
RS
D000368:Aged; D001279:Atracurium; D003875:Drug Eruptions / Q000209:etiology; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007546:Isoquinolines / Q000009:adverse effects / Q000494:pharmacology*; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects / Q000494:pharmacology*; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013514:Surgical Procedures, Operative; D013997:Time Factors; D014673:Vecuronium Bromide
D007546:Isoquinolines; D009466:Neuromuscular Blocking Agents; D001279:Atracurium; D014673:Vecuronium Bromide; D010197:Pancuronium