A comparison of the effects of fentanyl and alfentanil on the sleeping times of the intravenous induction agents.
The effect of increasing doses of fentanyl and alfentanil administered before four intravenous induction agents (thiopentone, methohexitone, Althesin and etomidate) on the sleeping time were studied in mice. A biphasic pattern of sleeping time was noted with the more rapidly metabolized and eliminated compounds. Possible explanations are discussed.
Dingwall
A E
AE
Pleuvry
B J
BJ
D000759:Adjuvants, Anesthesia / Q000008:administration & dosage / Q000494:pharmacology*; D015760:Alfentanil; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051379:Mice; D012890:Sleep / Q000187:drug effects*
D000759:Adjuvants, Anesthesia; D000777:Anesthetics; D015760:Alfentanil; D005283:Fentanyl