title: Somatostatin inhibits the dermorphin-stimulated thyrotropin release in man.
abstract: We have studied the effect of the intravenous administration of somatostatin (SRIF) on the thyrotropin (TSH) response to intravenous dermorphin (D), a new potent opioid peptide, in 7 healthy men. D significantly increased the serum TSH concentration. SRIF administration prior to, during and after D completely prevented the D-induced rise in serum TSH. These results confirm that D stimulates TSH release in man and that this stimulatory effect can be prevented by SRIF.
authors.forename: E C
authors.initials: EC
authors.lastname: degli Uberti
authors.forename: E
authors.initials: E
authors.lastname: Roti
authors.forename: G
authors.initials: G
authors.lastname: Trasforini
authors.forename: S
authors.initials: S
authors.lastname: Salvadori
authors.forename: A
authors.initials: A
authors.lastname: Margutti
authors.forename: G
authors.initials: G
authors.lastname: Robuschi
authors.forename: R
authors.initials: R
authors.lastname: Tomatis
authors.forename: A
authors.initials: A
authors.lastname: Gnudi
authors.forename: R
authors.initials: R
authors.lastname: Pansini
authors.forename: L E
authors.initials: LE
authors.lastname: Braverman
mesh_terms: D000293:Adolescent; D000328:Adult; D004723:Endorphins / Q000502:physiology; D006801:Humans; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D013004:Somatostatin / Q000494:pharmacology*; D013972:Thyrotropin / Q000097:blood*
chemical_list: D004723:Endorphins; D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin; D013004:Somatostatin; D013972:Thyrotropin