Common pharmaceuticals alter tissue proton NMR relaxation properties.
Differences in the tissue properties of water are the basis for the detailed anatomic visualization of internal body structures produced by NMR imaging. Physiological and pathological events have the potential to alter proton nuclear magnetic resonance relaxation properties through changes in water environment. In this study, the parenteral injection of pharmaceuticals produced significant changes (12-21%) in proton NMR relaxation times in tissues of treated rats. The extent of relaxation time change was both tissue specific and drug specific. Therefore, the effects of common pharmaceuticals should be considered in the interpretation of T1- and T2-weighted NMR images.
Karlik
S J
SJ
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001569:Benzodiazepines; D001834:Body Water / Q000187:drug effects; D001921:Brain / Q000033:anatomy & histology; D005260:Female; D006321:Heart / Q000033:anatomy & histology; D007668:Kidney / Q000033:anatomy & histology; D008099:Liver / Q000033:anatomy & histology; D008168:Lung / Q000033:anatomy & histology; D009682:Magnetic Resonance Spectroscopy; D009132:Muscles / Q000033:anatomy & histology; D009928:Organ Specificity; D004364:Pharmaceutical Preparations; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000033:anatomy & histology; D014599:Uterus / Q000033:anatomy & histology
D014151:Anti-Anxiety Agents; D004364:Pharmaceutical Preparations; D001569:Benzodiazepines