The acquisition of human lactoferrin by Mycoplasma pneumoniae.
We tested the in vitro binding of human iron-sequestering lactoferrin and transferrin by the mucosal-surface pathogens, Mycoplasma pneumoniae and Mycoplasma genitalium. Mycoplasma pneumoniae bound lactoferrin, but not transferrin, in a saturable and specific manner. Analysis of binding data indicates less than 10,000 lactoferrin receptors per micro-organism with a moderately high binding affinity of 20 nM. No significant binding of lactoferrin or transferrin by M. genitalium was observed.
Tryon
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VV
Department of Microbiology, University of Texas Health Science Center, San Antonio 78284-7758.
Baseman
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JB
D001667:Binding, Competitive; D006801:Humans; D007781:Lactoferrin / Q000378:metabolism*; D007782:Lactoglobulins / Q000378:metabolism*; D009174:Mycoplasma / Q000378:metabolism; D009177:Mycoplasma pneumoniae / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000032:analysis; D012709:Serum Albumin / Q000378:metabolism; D013696:Temperature; D013997:Time Factors; D014168:Transferrin / Q000378:metabolism
D007782:Lactoglobulins; D011956:Receptors, Cell Surface; D012709:Serum Albumin; D014168:Transferrin; C038340:lactoferrin receptors; D007781:Lactoferrin