title: [Arachidonic acid metabolites, leukotrienes--mediators of hypersensitivity and inflammation].
abstract: A problem of leukotrienes--metabolites of arachidonic acid is reviewed in immunological aspects. Their nomenclature is given; basic pathways of biosynthesis, transformation and mode of leukotriens participation in hypersensitivity and inflammatory reactions are considered. The possibility of application of leukotrienes antagonists and inhibitors of their formation for allergic diseases treatment is discussed.
authors.forename: V A
authors.initials: VA
authors.lastname: Konyshev
authors.forename: I N
authors.initials: IN
authors.lastname: Marokko
authors.forename: V A
authors.initials: VA
authors.lastname: Shaternikov
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004357:Drug Synergism; D006168:Guinea Pigs; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D007249:Inflammation / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000276:immunology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D011817:Rabbits; D011971:Receptors, Immunologic / Q000378:metabolism; D013189:SRS-A / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000276:immunology*; D013329:Structure-Activity Relationship; D009626:Terminology as Topic; D013928:Thromboxane A2 / Q000096:biosynthesis
chemical_list: D000941:Antigens; D001095:Arachidonic Acids; D018377:Neurotransmitter Agents; D011971:Receptors, Immunologic; D013189:SRS-A; D007975:Leukotriene B4; D013928:Thromboxane A2
vernacular_title: Metabolity arakhidonovoĭ kisloty leĭkotrieny--mediatory giperchuvstvitel'nosti i vospaleniia.