Protection of mice against mixed fission neutron-gamma (n: gamma = 1:1) irradiation by WR-2721, 16,16-dimethyl PGE2, and the combination of both agents.
The survival of mice after whole-body exposure to a modified fission neutron-gamma field (n: gamma = 1:1) was used to examine radiation protection by WR-2721, 16,16-dimethyl PGE2(DiPGE2), and the combination of both agents. Administration of WR-2721 (453 mg/kg) increased the LD50/30 from 5.24 to 7.17 Gy (DMF = 1.37), whereas pretreatment with DiPGE2 (1.6 mg/kg) increased the LD50/30 to 5.77 Gy (dose modification factor (DMF) = 1.10). The combination of 453 mg/kg WR-2721 and 0.4 mg/kg DiPGE2 resulted in an LD50/30 of 7.33 Gy, yielding a DMF of 1.39. However, no significant difference in protection was obtained with the combination of the two agents compared to that seen with WR-2721 alone.
Steel
L K
LK
Radiation Biochemistry, Department Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20814-5145.
Walden
T L
TL
Hughes
H N
HN
Jackson
W E
WE
D015064:16,16-Dimethylprostaglandin E2 / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D004999:Amifostine / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D004359:Drug Therapy, Combination; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009502:Neutrons; D009946:Organothiophosphorus Compounds / Q000627:therapeutic use*; D011459:Prostaglandins E, Synthetic / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents
D009946:Organothiophosphorus Compounds; D011459:Prostaglandins E, Synthetic; D011837:Radiation-Protective Agents; D004999:Amifostine; D015064:16,16-Dimethylprostaglandin E2