Biochemical investigation of human tumours in vivo with phosphorus-31 magnetic resonance spectroscopy.
The bioenergetic state of 15 human tumours was examined with phosphorus-31 magnetic resonance spectroscopy. A striking diversity in metabolic patterns was observed, and significant differences from normal tissue were seen in all cases. A common feature was an elevation of intracellular pH, which may be related to an increase in Na+/H+ exchange during cell activation. It is unlikely that the patterns observed directly correlate with malignancy, but characterisation of the energetic state of a given tumour in a given physiological environment may help in the design and evaluation of interventions for that specific case.
Oberhaensli
R D
RD
Hilton-Jones
D
D
Bore
P J
PJ
Hands
L J
LJ
Rampling
R P
RP
Radda
G K
GK
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis / Q000378:metabolism; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008113:Liver Neoplasms / Q000175:diagnosis / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D010761:Phosphorus Radioisotopes; D013057:Spectrum Analysis / Q000379:methods*
D010761:Phosphorus Radioisotopes