Experimental chemotherapy of rabies. Preliminary results.
The effect of 17 immunosuppressive, cytostatic or antiviral agents on the course of illness in weanling conventional mice infected intracerebrally (i.c.) or intramuscularly (i. m.) with lethal or sublethal doses of rabies virus strains isolated from fox and small wild rodents was studied. Potentiation or suppression of virulence by the same compound with some virus strains depended on the route of infection. The best protective effect on i.c. and i. m. infections was achieved with iododeoxyuridine (IUdR) and Actinomycin D on i.c. and with 6-azacytidine and Imuran on i.m. infections, respectively.
Sodja
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D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005589:Foxes; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D051379:Mice; D011818:Rabies / Q000188:drug therapy*; D011820:Rabies virus / Q000302:isolation & purification
D000998:Antiviral Agents; D007166:Immunosuppressive Agents