Alpha-globin gene organisation and prenatal diagnosis of alpha-thalassaemia in Chinese.
DNA samples from 60 Chinese patients with haemoglobin H disease were analysed by restricted endonuclease mapping to determine the patterns of alpha-globin gene organisation and the distribution of these patterns in China. Restriction endonuclease analysis and rapid micro-DNA hybridisation on nitrocellulose membranes were also used to analyse DNA from amniotic fluid cells or from chorionic villi in 7 pregnancies at risk of haemoglobin Barts hydrops fetalis, in 1 at risk of haemoglobin H disease, and 1 at risk of both disorders.
Zeng
Y T
YT
Huang
S Z
SZ
D000653:Amniotic Fluid / Q000166:cytology; D001345:Autoradiography; D002681:China; D002824:Chorionic Villi / Q000648:ultrastructure; D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes; D005260:Female; D005796:Genes; D005914:Globins / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013789:Thalassemia / Q000175:diagnosis* / Q000235:genetics
D005914:Globins; D004262:DNA Restriction Enzymes