Drug delivery to the proximal colon.
The transits of a capsule and a multiparticulate pellet system have been monitored through the gastrointestinal tract in six healthy volunteers. Both preparations moved together through the stomach and small intestine, reaching the colon, on average, 4 h after dosing. Within the colon the pellets dispersed and moved at a slower rate than the capsule. There was considerable intersubject variability in the large bowel transit times. The findings are discussed in terms of drug delivery to the colon.
Hardy
J G
JG
Wilson
C G
CG
Wood
E
E
D000328:Adult; D002214:Capsules; D003106:Colon / Q000187:drug effects* / Q000502:physiology; D003692:Delayed-Action Preparations; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D013997:Time Factors
D002214:Capsules; D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations