title: Disaccharidase deficiency in amniotic fluid from cases of cystic fibrosis.
abstract: The activities of the disaccharidases maltase and sucrase in 4 amniotic fluid from cystic fibrosis (CF) pregnancies have been compared to those of 120 non CF-pregnancies. Very low levels were found in 3 of the CF-fluids. The fourth CF-fluid was normal in all measured microvillar enzyme activities. Elevated levels of disaccharidases in meconium from one of the patients born with CF, supports the idea that these enzymes are trapped in the intestinal cavity by sticky meconium.
authors.forename: M
authors.initials: M
authors.lastname: Schwartz
authors.forename: N J
authors.initials: NJ
authors.lastname: Brandt
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000201:enzymology*; D003550:Cystic Fibrosis / Q000175:diagnosis* / Q000201:enzymology; D004186:Disaccharidases / Q000032:analysis / Q000172:deficiency*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008470:Meconium / Q000032:analysis; D011247:Pregnancy; D013393:Sucrase / Q000032:analysis; D000520:alpha-Glucosidases / Q000032:analysis; D005723:gamma-Glutamyltransferase / Q000032:analysis
chemical_list: D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D004186:Disaccharidases; D000520:alpha-Glucosidases; D013393:Sucrase