The effect of some drugs on the mitral cell odor-evoked responses in the gecko olfactory bulb.
The activity of odor-evoked olfactory mitral cell response of the gecko was recorded extracellularly by glass microelectrodes. The activities of the mitral cell observed during the presentation of the odor (n-amyl acetate) could be described as excitation, suppression or zero. The present experiments were undertaken to study the neural activities of the mitral cell in the olfactory bulb by perfusion application of some drugs (cobalt chloride, carnosine, norepinephrine, GABA and D-L-homocysteate) on the olfactory bulb surface or iontophoretic application of some drugs (carnosine, norepinephrine, GABA and D-L-homocysteate) to the glomerulus and the external plexiform layer to change the physiological environment. The effect of the drugs suggested that the synaptic neurons on the mitral cell have different chemical characteristics.
Tonosaki
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Shibuya
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D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002336:Carnosine / Q000494:pharmacology; D002490:Central Nervous System / Q000502:physiology*; D003035:Cobalt / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D006710:Homocysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D008116:Lizards / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D009830:Olfactory Bulb / Q000502:physiology; D009833:Olfactory Pathways / Q000166:cytology / Q000502:physiology*; D012903:Smell / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D006710:Homocysteine; C007956:homocysteic acid; D003035:Cobalt; D005680:gamma-Aminobutyric Acid; D002336:Carnosine; D009638:Norepinephrine