Interaction of some beta-receptor blockers with the transport system of glucose in human erythrocytes.
The influence of 15 of the most frequently used beta-receptor blockers on the glucose transport in human erythrocytes was investigated. It was found out that 10 compounds have no effect on the glucose transport and that their lipophilicities are very low. The inhibition constants and the inhibition kinetics of the glucose uptake of the other 5 beta-receptor blockers were estimated. No correlation exists between their affinities to the glucose transport sites and the partition coefficients.
Lacko
L
L
Wittke
B
B
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D001693:Biological Transport, Active / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D013329:Structure-Activity Relationship
D000319:Adrenergic beta-Antagonists; D001786:Blood Glucose