A comparison of cefotetan and cephazolin for prophylaxis against wound infection after elective cholecystectomy.
In a prospective randomized study 168 patients received a single dose of either cephazolin or cefotetan (1 g) as a prophylactic against wound infection after cholecystectomy. In the cephazolin group 10.3% and the cefotetan group 14.4% developed wound infections (Chi-squared = 0.34 P = less than 0.6 greater than 0.5).
Drumm
J
J
Donovan
I A
IA
Wise
R
R
D002437:Cefazolin / Q000627:therapeutic use*; D015313:Cefotetan; D002513:Cephamycins / Q000627:therapeutic use*; D002763:Cholecystectomy / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects; D006801:Humans; D011446:Prospective Studies; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000517:prevention & control*
D002513:Cephamycins; D015313:Cefotetan; D002437:Cefazolin