In vivo synthesis and processing of rat hypothalamic prosomatostatin.
The in vivo incorporation of [3H]phenylalanine into an apparent 15 kDa prosomatostatin was observed in the hypothalamus of rats injected with the labeled amino acid in the third ventricle. Precursor-product relationships were established between this newly synthesized material and both somatostatin-28 and -14.
Camier
M
M
Barre
N
N
Morel
A
A
Cohen
P
P
D000818:Animals; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D011498:Protein Precursors / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000096:biosynthesis / Q000378:metabolism*; D053561:Somatostatin-28
D011498:Protein Precursors; D013004:Somatostatin; C028456:prosomatostatin; D053561:Somatostatin-28