Dopamine receptor agonistic activities of R- and S-enantiomers of 4-hydroxy-2-di-n-propylaminoindan in cat hearts.
In-vitro and in-vivo studies were used to evaluate the presynaptic dopamine receptor stimulating activities of R- and S-enantiomers of 4-hydroxy-2-di-n-propylaminoindan in cat hearts. Bioassay results show that the R-enantiomer is 100 times more potent than the S-enantiomer in both in-vitro and in-vivo preparations.
Ilhan
M
M
Flynn
J R
JR
Long
J P
JP
Bhatnagar
R K
RK
Cannon
J G
JG
D000818:Animals; D002415:Cats; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007189:Indans / Q000494:pharmacology*; D007192:Indenes / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000187:drug effects*; D013237:Stereoisomerism
D007189:Indans; D007192:Indenes; D011954:Receptors, Dopamine; C044899:4-hydroxy-2-(di-n-propylamino)indan