Cultured neurofibromatosis tumor fibroblasts lack beta-adrenergic receptors.
Beta-adrenergic receptors on cultured neurofibromatosis (NF) skin and tumor fibroblasts were characterized by a radioligand binding assay using (-)-125I-iodocyanopindolol (ICYP), a potent beta-antagonist. NF tumor fibroblasts had a very low density of beta-adrenergic receptors (0-450 binding sites/cell) when compared to fibroblasts obtained from a healthy skin area of NF patients or from healthy controls (average 1,800 binding sites/cell). The apparently low binding of ICYP to the NF tumor fibroblasts can be an expression of an alteration in the structure or function of the plasma membrane.
Kaila
T
T
Department of Pharmacology, University of Turku, Finland.
Penttinen
R
R
Peltonen
J
J
D005347:Fibroblasts / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D020120:Iodocyanopindolol; D009456:Neurofibromatosis 1 / Q000378:metabolism*; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D011943:Receptors, Adrenergic, beta; D020120:Iodocyanopindolol; D010869:Pindolol