Peri-incisional mezlocillin versus rectal-metronidazole for wound infection prophylaxis.
One hundred and forty patients who underwent appendicectomy were included in a prospective randomized trial to compare the ability of preoperative rectal metronidazole and peri-incisional mezlocillin to prevent wound infection following appendicectomy. The results show that bactericidal local tissue levels of mezlocillin were uniformly achieved using the peri-incisional technique. The wound infection rate for the metronidazole group was found to be 15.9% and did not significantly differ from the wound infection rate when mezlocillin was used (10.4%). Peri-incisional mezlocillin therefore appears to be a viable prophylactic technique against wound infection following appendicectomy and may offer a cheaper alternative to intravenous intra-operative metronidazole administration in cases when pre-operative metronidazole suppositories have been omitted. The peri-incisional mezlocillin technique is also suitable for routine prophylaxis against wound infection following appendicectomy.
Porteous
C
C
Davidson
P M
PM
Rawluk
D
D
Brown
M
M
Scott
R
R
Conn
G
G
McClure
A
A
Murray
W R
WR
D000293:Adolescent; D000328:Adult; D001062:Appendectomy; D001442:Bacteroides Infections / Q000517:prevention & control; D001441:Bacteroides fragilis; D002648:Child; D002986:Clinical Trials as Topic; D004927:Escherichia coli Infections / Q000517:prevention & control; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008802:Mezlocillin / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011446:Prospective Studies; D011897:Random Allocation; D012007:Rectum; D013488:Suppositories; D013530:Surgical Wound Infection / Q000517:prevention & control*
D013488:Suppositories; D008795:Metronidazole; D008802:Mezlocillin