Somatostatin and (D-Trp8, D-Cys14)-somatostatin delay extinction and reverse electroconvulsive shock induced amnesia in rats.
In the present study the effects of somatostatin and its analogs on active avoidance behavior, electroconvulsive shock (ECS)-induced retrograde amnesia, and spatial-discrimination learning were compared in rats. (D-Trp8, D-Cys14)-somatostatin (as did the somatostatin molecule itself) delayed the extinction of active avoidance behavior, antagonized ECS-induced amnesia, and did not modify spatial-discrimination learning. Des-Asn5-(D-Trp8, D-Ser13) somatostatin and des-AA1,2,4,5,12,13,-(D-Trp8) somatostatin did not influence these behaviors. The data suggest that certain parts of the somatostatin molecule are important for its behavioral actions.
Vécsei
L
L
Bollók
I
I
Penke
B
B
Telegdy
G
G
D000647:Amnesia / Q000628:therapy*; D000648:Amnesia, Retrograde / Q000628:therapy*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004193:Discrimination Learning / Q000187:drug effects*; D005108:Extinction, Psychological / Q000187:drug effects; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D013004:Somatostatin / Q000031:analogs & derivatives / Q000494:pharmacology*; D013028:Space Perception / Q000187:drug effects; D013329:Structure-Activity Relationship
D010446:Peptide Fragments; D013004:Somatostatin; C020948:somatostatin, Trp(8)-Cys(14)-; C017583:somatostatin, octapeptide-Trp(8)-; C022928:somatostatin, de-Asn(5)-Trp(8)-Ser(13)-