title: Metronidazole neuropathy: a case report.
abstract: A 67-year-old man developed peripheral neuropathy characterized by glove and stocking type sensory disturbances after the ingestion of 101.25 g of metronidazole for hepatic amebiasis. The clinical pictures of metronidazole-induced neuropathy appears to be the same as that of myeloneuropathy. The morphological study of a sural nerve biopsy showed a severe loss of myelinated fibers (2,400 per mm2). The density of unmyelinated fibers was at a lower limit of the normal range (23,530 per mm2). Electronmicroscopy confirmed the axonal degeneration of both the myelinated fibers and unmyelinated fibers.
authors.affiliation: Department of Internal Medicine, Kagawa Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takeuchi
authors.forename: A
authors.initials: A
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Touge
authors.forename: H
authors.initials: H
authors.lastname: Miki
authors.forename: M
authors.initials: M
authors.lastname: Nishioka
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
mesh_terms: D000368:Aged; D001369:Axons / Q000648:ultrastructure; D001706:Biopsy; D004576:Electromyography; D006801:Humans; D008101:Liver Abscess, Amebic / Q000188:drug therapy*; D008297:Male; D008795:Metronidazole / Q000009:adverse effects* / Q000627:therapeutic use; D009132:Muscles / Q000294:innervation; D009469:Neuromuscular Junction / Q000187:drug effects; D010525:Peripheral Nerves / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D008795:Metronidazole