Concomitant immunity leads to retardation or acceleration of the growth of Rous sarcomas in genetically resistant or susceptible inbred lines of chickens.
We report results on the age-dependent effect of the B (MHC) genotype on resistance to the growth of a second RSV tumour in chickens from highly inbred lines genetically resistant or susceptible to progressive growth of primary RSV-induced tumours. Furthermore, the second inoculation of RSV caused either accelerated or retarded growth of the primary tumours induced by the same virus. These two types of response to a second challenge with RSV were controlled by alleles of the chicken major histocompatibility (B) complex. The retarded growth of the primary tumours was found to be thymus-dependent. Furthermore, a clear-cut trans-complementation effect of two B alleles on the response to RSV challenge was demonstrated.
Plachý
J
J
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha.
Karakoz
I
I
Benda
V
V
D000367:Age Factors; D000483:Alleles; D000818:Animals; D002645:Chickens; D005816:Genetic Complementation Test; D005838:Genotype; D008285:Major Histocompatibility Complex; D001357:Sarcoma, Avian / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology