Changes in the macrophage function with aging.
Changes in the adherence, opsonization, phagocytosis, nitroblue tetrazolium reduction and antibody-dependent cell cytotoxicity of peritoneal macrophages were observed with aging in BALB/C mice. A decrease in all the parameters studied, except for the reduction capacity of nitroblue tetrazolium, which increased with aging, was found in the long-lived mice. The role of the macrophage in immune hyporesponsiveness with aging is discussed.
De La Fuente
M
M
D000375:Aging; D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002448:Cell Adhesion; D002478:Cells, Cultured; D005260:Female; D008264:Macrophages / Q000166:cytology / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis