title: Effect of atrial natriuretic factor on renin secretion, plasma renin and aldosterone in dogs with acute unilateral renal artery constriction.
abstract: Atrial natriuretic factor (ANF) decreases renin secretion rate (RSR), plasma renin activity (PRA) and plasma aldosterone (PA) in normal dogs. To clarify further the mechanisms responsible for these effects, the left renal artery was constricted in seven anaesthetized dogs prior to ANF administration. Constriction of the left renal artery decreased (P < 0.05) ipsilateral mean renal perfusion pressure (MRPP, 29 +/- 7%), renal plasma flow (RPF, 42 +/- 11%) and glomerular filtration rate (GFR) and filtered sodium load (FLNa, 21 +/- 8.8%). Ipsilateral RSR and peripheral PRA tended to increase, although not significantly. Atrial natriuretic factor infusion did not alter GFR in the clamped kidney and failed to decrease RSR or PRA. Despite this, PA levels decreased significantly (7.8 +/- 2.4 to 5.6 +/- 1.8 ng%). These results suggest that ANF-induced inhibition of renin secretion is largely consequent on its renal haemodynamic actions and that suppression of aldosterone by ANF in vivo is due, in part, to direct effects on the adrenal cortex.
authors.affiliation: Cardiovascular Center, Cornell University Medical College, New Yor, NY 10021.
authors.forename: R E
authors.initials: RE
authors.lastname: Sosa
authors.forename: M
authors.initials: M
authors.lastname: Volpe
authors.forename: D N
authors.initials: DN
authors.lastname: Marion
authors.forename: N
authors.initials: N
authors.lastname: Glorioso
authors.forename: J H
authors.initials: JH
authors.lastname: Laragh
authors.forename: E D
authors.initials: ED
authors.lastname: Vaughan
authors.forename: T
authors.initials: T
authors.lastname: Maack
authors.forename: S A
authors.initials: SA
authors.lastname: Atlas
mesh_terms: D000450:Aldosterone / Q000097:blood*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007677:Kidney Function Tests; D012078:Renal Artery Obstruction / Q000097:blood* / Q000503:physiopathology; D012079:Renal Circulation / Q000187:drug effects; D012083:Renin / Q000097:blood / Q000378:metabolism*
chemical_list: D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin