The interaction of lithium with forskolin-inhibited meiotic maturation of denuded mouse oocytes.
Lithium reverses at millimolar concentrations and in a dose-dependent manner the inhibition of meiotic reinitiation (GVBD) induced by an activator of adenylate cyclase, forskolin, and does this independently of exogenous myo-inositol. These results argue for a pivotal role of adenylate cyclase in the regulation of meiotic resumption and for a possible action of lithium on G proteins rather than at the level of phosphatidylinositol resynthesis.
Gavin
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AC
Department of Obstetrics and Gynecology, Hôpital Cantonal Universitaire, Geneva, Switzerland.
Schorderet-Slatkine
S
S
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D005576:Colforsin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008094:Lithium / Q000494:pharmacology*; D008540:Meiosis / Q000187:drug effects*; D051379:Mice; D009865:Oocytes / Q000166:cytology* / Q000187:drug effects
D005576:Colforsin; D003994:Bucladesine; D008094:Lithium