The responsiveness of mice B-lymphocytes to neuromediators during an immune reaction.
It was shown that increases of cAMP levels before and after adrenaline (10(-6) mol/liter) and cAMP levels before and after acetylcholine (10(-6) mol/liter) occur in mouse spleen B-lymphocytes in 2-3 and 3-6 days, respectively, after immunization with ovalbumin. Using radiolabeled blockers of these neuroreceptors, it was shown that their receptors on B-lymphocytes increase 3 and 3-4 days, respectively, after immunization. The data indicate that increases of spleen B-lymphocyte reactivity to neuromediators occur during an immune reaction associated, in part, with increases in the expression of their receptors.
Ado
A D
AD
Institute of Imunology, USSR Ministry of Health, Moscow.
Goldshtein
M M
MM
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D002455:Cell Division / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism*; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D007107:Immune System / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D010047:Ovalbumin; D013154:Spleen / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism
D010047:Ovalbumin; D000242:Cyclic AMP; D000109:Acetylcholine; D004837:Epinephrine