Adult T-cell leukemia in two siblings. Acute crisis of smoldering disease in one patient.
Two cases of human T-cell leukemia virus (HTLV)-positive adult T-cell leukemia (ATL) in brother and sister are presented. Six of 15 members of this family were seropositive for antibodies for ATL-associated antigens (ATLA). The sister of the ATL patient developed overt ATL after 5 years and 8 months of smoldering ATL. Immunologic examinations during the smoldering phase were normal except for negative skin tests for purified protein derivative. Factors leading to the induction of ATL among HTLV carriers remain to be studied.
Taguchi
H
H
Niiya
K
K
Kubonishi
I
I
Yano
S
S
Yoshimoto
S
S
Fujishita
M
M
Kitagawa
T
T
Mitani
M
M
Miyoshi
I
I
D000208:Acute Disease; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002353:Carrier State; D015480:Deltaretrovirus Antibodies; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012192:Retroviridae Infections / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
D000914:Antibodies, Viral; D000970:Antineoplastic Agents; D015480:Deltaretrovirus Antibodies