Primitive neuroectodermal tumor presenting as a delayed sequela to cranial irradiation and intrathecal methotrexate.
A patient developed a primitive neuroectodermal tumor (PNET) many years after therapeutic cerebral radiation and methotrexate treatment for leukemia. The differential radiologic and histologic diagnoses, as well as the possible co-oncogenic effects of radiation and methotrexate, are evaluated.
Barasch
E S
ES
Department of Neuroradiology, Albert Einstein College of Medicine, Bronx, New York.
Altieri
D
D
Decker
R E
RE
Ahmed
S
S
Lin
J
J
D000293:Adolescent; D001932:Brain Neoplasms / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007276:Injections, Intraventricular; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D009373:Neoplasms, Germ Cell and Embryonal / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000000981:diagnostic imaging / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D014057:Tomography, X-Ray Computed
D008727:Methotrexate