Influence of cyclosporin A on the respiration of isolated rat kidney mitochondria.
In vitro exposure of isolated rat kidney mitochondria to cyclosporin A, a new immunosuppressive agent with serious nephrotoxic side-effects, leads to alterations of both succinate- and glutamate plus malate-supported respiration in a dose-related manner. ADP- and 2,4-dinitrophenol-stimulated respiration, respiratory control indices, and ADP/O ratios are decreased. The mitochondrial alterations are discussed as possible pathogenetic reasons of cyclosporin A nephrotoxicity.
Jung
K
K
Pergande
M
M
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D007668:Kidney / Q000648:ultrastructure*; D008293:Malates / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid
D003524:Cyclosporins; D005971:Glutamates; D008293:Malates; D013386:Succinates; D018698:Glutamic Acid; D000244:Adenosine Diphosphate; C030298:malic acid; D019802:Succinic Acid