Effects of various thiols on paraquat toxicity.
It was demonstrated that cysteine and D-penicillamine are able to replace reduced glutathione to some extent in the glutathione peroxidase reaction. An in vivo study was made of the role played by--SH compounds in the antioxidant enzyme system involved in the detoxication of the LD50 of paraquat (PQ), and hence of their role in the detoxication of PQ. The effectiveness was D-PA greater than GSH greater then Cys in the liver and GSH greater than Cys greater than D-PA in the lung.
Szabó
L
L
Matkovics
B
B
Barabás
K
K
Oroszlán
G
G
D000818:Animals; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D010269:Paraquat / Q000633:toxicity*; D010396:Penicillamine / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
D008054:Lipid Peroxides; D011506:Proteins; D013438:Sulfhydryl Compounds; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D010396:Penicillamine; D010269:Paraquat