Simultaneous determination of Pt and essential trace elements in plasma by energy dispersive x-ray fluorescence (EDXRF).
Energy dispersive x-ray fluorescence allows the simultaneous determination of platinum and essential trace-elements in plasma and filtered plasma. Pharmacokinetics of platinum and the variations of trace-elements levels with respect to the normal mean values before and during the treatment are reported. Particularly during the treatment we observed that total iron concentration clearly increases in plasma, which suggests a hemolytic effect of the drug. However we can exclude this hypothesis by the simultaneous determination of potassium and rubidium levels, which do not increase as greatly as in hemolysed samples.
Sargentini-Maier
M L
ML
Ecole Européenne des Hautes Etudes des Industries Chimiques de Strasbourg (EHICS), Laboratoire de Chimie Minérale, U.A. 405 du C.N.R.S, France.
Maier
E A
EA
Ruch
C
C
Dufour
P
P
Oberling
F
F
Leroy
M J
MJ
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D005374:Filtration; D006801:Humans; D010984:Platinum / Q000097:blood*; D013052:Spectrometry, X-Ray Emission; D013997:Time Factors; D014131:Trace Elements / Q000097:blood*
D014131:Trace Elements; D010984:Platinum; D002945:Cisplatin