Sudden death of a volunteer.
A volunteer participating in a study of eproxindine, a new antiarrhythmic agent, had a sudden cardiorespiratory arrest and died. Subsequently it became known that he had received a depot injection of flupenthixol on the day before his death; an interaction between these two drugs seems likely. This incident illustrates that it is impossible to guarantee absolute safety in volunteer studies if details of medical history are withheld.
Darragh
A
A
Kenny
M
M
Lambe
R
R
Brick
I
I
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects; D002986:Clinical Trials as Topic; D003645:Death, Sudden / Q000209:etiology*; D004347:Drug Interactions; D005475:Flupenthixol / Q000009:adverse effects; D006801:Humans; D007211:Indoles / Q000009:adverse effects*; D008297:Male; D000078183:Oxindoles
D000889:Anti-Arrhythmia Agents; D007211:Indoles; D000078183:Oxindoles; C044002:eproxindine; D005475:Flupenthixol