Common DNA polymorphism within coding sequence of apolipoprotein B gene associated with altered lipid levels.
60 of 83 middle-aged white men had an XbaI restriction site polymorphism within the coding sequence of the apolipoprotein B gene. Subjects homozygous and heterozygous for the presence of an XbaI restriction site had mean serum triglyceride levels 36% higher (p = 0.02) than those in homozygotes without the restriction site; there was a less substantial difference (p = 0.03) in serum cholesterol. The findings supported a dominant pattern of inheritance. The presence of this restriction site may increase the risk of atherosclerotic disease.
Law
A
A
Wallis
S C
SC
Powell
L M
LM
Pease
R J
RJ
Brunt
H
H
Priestley
L M
LM
Knott
T J
TJ
Scott
J
J
Altman
D G
DG
Miller
G J
GJ
D001055:Apolipoproteins B / Q000235:genetics*; D001161:Arteriosclerosis / Q000235:genetics; D001483:Base Sequence; D002784:Cholesterol / Q000097:blood*; D004247:DNA / Q000032:analysis*; D004262:DNA Restriction Enzymes; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk; D014280:Triglycerides / Q000097:blood*
D001055:Apolipoproteins B; D014280:Triglycerides; D004247:DNA; D002784:Cholesterol; D004262:DNA Restriction Enzymes