Cholinergic involvement in the modulation of oxotremorine-tremor in mice by propranolol.
Propranolol in low doses antagonized and in higher doses facilitated oxotremorine-induced tremor (Oxo-tremor) in mice. Atropine blocked Oxo-tremor, an effect that was reversed by propranolol. Atropine pretreatment also antagonized the potentiating effect of propranolol on Oxo-tremor. Propranolol inhibited mice brain cholinesterase at doses which enhanced Oxo-tremor. Timolol and sotalol produced a dose-dependent antagonism of Oxo-tremor, whereas practolol failed to produce a similar effect. None of these three agents produced any significant enhancement of Oxo-tremor. These results suggest the involvement of a peripheral mechanism for the antagonism and a central cholinergic mechanism for the facilitation of Oxo-tremor by propranolol.
Alkondon
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M
Ray
A
A
Sen
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P
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007531:Isoflurophate / Q000494:pharmacology; D008297:Male; D051379:Mice; D010095:Oxotremorine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D014202:Tremor / Q000139:chemically induced* / Q000188:drug therapy
D000319:Adrenergic beta-Antagonists; D002800:Cholinesterase Inhibitors; D007531:Isoflurophate; D010095:Oxotremorine; D001285:Atropine; D011433:Propranolol