Liver tumor in long-term user of oral contraceptives.
Oral contraceptives are implicated in the development of some liver tumors. Paralleling the widespread use of these drugs has been an increase in reported cases of hepatic cell adenomas. Large, multiple tumors, often manifested by spontaneous rupture and hemoperitoneum, have been associated with prolonged use of oral contraceptives. When use of oral contraceptives is discontinued, the hepatic cell adenoma regresses.
Ferrara
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BE
University of Florida College of Medicine, Lake City.
Rutland
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ED
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D004967:Estrogens / Q000009:adverse effects; D004997:Ethinyl Estradiol / Q000009:adverse effects; D005260:Female; D006470:Hemorrhage / Q000209:etiology / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D009644:Norgestrel / Q000009:adverse effects; D012422:Rupture, Spontaneous
D003277:Contraceptives, Oral, Combined; D004967:Estrogens; D009644:Norgestrel; D004997:Ethinyl Estradiol