Ganglionic blockade in conscious dogs with chronic caval constriction.
Chronic constriction of the thoracic inferior vena cava decreases venous return and cardiac output, increases the secretion of renin and aldosterone, and produces sodium retention with ascites and edema formation. The arterial pressure is maintained at normotensive levels in this caval model by an increase in total peripheral resistance. The objective of the present study was to compare renal and hemodynamic responses to ganglionic blockade in the conscious thoracic caval dog to responses obtained in another low-output model, the chronic sodium-deplete dog, and also to the responses obtained in the normal sodium-replete dog. The control base-line pressures averaged 103 +/- 2, 110 +/- 3, and 110 +/- 3 mmHg, respectively, in the sodium-replete, sodium-deplete, and thoracic caval dogs (P greater than 0.05). Ganglionic blockade in the conscious dog with caval constriction resulted in a sustained 20- to 30-mmHg fall in the arterial pressure; a sustained fall of 20 mmHg occurred in the sodium-deplete dogs. In contrast, ganglionic blockade failed to decrease the blood pressure at any time in the normal sodium-replete animals. Effective renal blood flow and creatinine clearance failed to demonstrate sustained changes after ganglionic blockade in any group of dogs; renal sodium excretion increased only in the normal sodium-replete dogs. These results suggest an enhanced contribution of the sympathetic nervous system to blood pressure maintenance in both the sodium-deplete and the caval dogs. Although the data fail to demonstrate an important contribution of the adrenergic system in the chronic sodium retention in these two experimental models, decreases in renal perfusion pressure may have blunted any potential natriuresis in these animals following ganglionic blockade.
Sweet
W D
WD
Freeman
R H
RH
Davis
J O
JO
Vari
R C
RC
D000818:Animals; D002908:Chronic Disease; D003243:Consciousness; D003251:Constriction, Pathologic / Q000503:physiopathology; D004285:Dogs; D004837:Epinephrine / Q000097:blood; D005260:Female; D005724:Ganglia / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007668:Kidney / Q000503:physiopathology; D009407:Nerve Block; D009638:Norepinephrine / Q000097:blood / Q000494:pharmacology; D012083:Renin / Q000097:blood; D013909:Thorax; D014682:Vena Cava, Inferior / Q000503:physiopathology*
D006584:Hexamethonium Compounds; D018738:Hexamethonium; D012083:Renin; D009638:Norepinephrine; D004837:Epinephrine