Non-steroidal anti-inflammatory drugs and renal failure.
In 3 years seventeen patients presented to one unit with renal failure associated with the use of non-steroidal anti-inflammatory drugs (NSAID). Seven patients presented with acute renal failure, in four due to acute tubular necrosis and in three to acute interstitial nephritis; all recovered when NSAID treatment was stopped. Four patients presented with symptomless renal impairment discovered during routine follow-up in a rheumatology clinic; again all improved on withdrawal of NSAID. The remaining six patients presented with chronic renal failure, a disorder not previously associated with NSAID treatment. The pattern of renal disease associated with NSAID may be more extensive than has previously been recognised. A history of NSAID use should be sought in all patients presenting with unexplained renal failure.
Adams
D H
DH
Howie
A J
AJ
Michael
J
J
McConkey
B
B
Bacon
P A
PA
Adu
D
D
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001032:Apazone / Q000009:adverse effects; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000009:adverse effects; D009395:Nephritis, Interstitial / Q000139:chemically induced; D010894:Piroxicam; D011507:Proteinuria / Q000139:chemically induced; D013843:Thiazines / Q000009:adverse effects
D000893:Anti-Inflammatory Agents; D013843:Thiazines; D010894:Piroxicam; D009288:Naproxen; D003404:Creatinine; D001032:Apazone