Chloroquine-resistant Plasmodium falciparum malaria in Ethiopia.
Standard triple-dose therapy with chloroquine (25 mg base/kg) failed to clear asexual Plasmodium falciparum parasites from the blood of 22 of 98 patients infected in various parts of Ethiopia and evaluated in Addis Ababa, a malaria-free city. RI to RIII levels of resistance were demonstrated in those patients. The resistant isolates were confined to areas bordering Somalia, Kenya, and Sudan. In in-vitro tests 7 of 10 (70%) isolates were chloroquine-resistant.
Teklehaimanot
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D000293:Adolescent; D000328:Adult; D002738:Chloroquine / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D005002:Ethiopia; D005260:Female; D006801:Humans; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000187:drug effects
D002738:Chloroquine