Increased neutrophil leukocyte chemotaxis induced by release of a serum factor in toluene-diisocyanate (TDI) asthma.
The activation of blood neutrophil leukocytes has been proven in subjects with IgE-mediated and non-IgE-mediated asthma. This event appears to be modulated by the release of humoral factors. We submitted 12 toluene-diisocyanate (TDI) asthmatic workers to TDI provocation. During the late asthmatic reaction there was release of a serum chemoattracting factor for normal neutrophil leukocytes and activation of asthmatic neutrophil leukocytes. This appears to be the first demonstration of neutrophil chemotactic activity liberated during the late TDI reaction in humans. The results are explained by an acute inflammatory process occurring during the late asthmatic reaction induced by TDI.
Valentino
M
M
Institute of Occupational Medicine, University of Ancona, Hospital Torrette, Italy.
Governa
M
M
Fiorini
R
R
D000328:Adult; D001249:Asthma / Q000139:chemically induced / Q000276:immunology*; D001985:Bronchial Provocation Tests; D002630:Chemotactic Factors / Q000096:biosynthesis*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003485:Cyanates / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016209:Interleukin-8; D008297:Male; D009504:Neutrophils / Q000276:immunology; D009784:Occupational Diseases / Q000139:chemically induced / Q000276:immunology; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects*
D002630:Chemotactic Factors; D003485:Cyanates; D016209:Interleukin-8; D014051:Toluene 2,4-Diisocyanate