Effectiveness of prophylactic administration of epsilon-amino caproic acid during influenza in mice.
Epsilon-amino caproic acid (E-ACA), a proteolysis inhibitor, has been found to limit the development of various forms of experimental influenza infection in mice. In sublethal infection, the extent of influenza A virus reproduction in the lungs was reduced 2 and 10 days after a single dose of E-ACA as well as 4 weeks after a 5-day prophylactic course. This correlated with the ability of proteolysis inhibitor to stimulate early production of specific serum antibodies. The favourable effect of prophylactic administration of E-ACA was especially marked in experimental lethal influenza caused by the pathogenic influenza A0/32 (H1N1) strain; a significant protection was observed from days 3 to 14 post-infection (p.i.).
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Polyak RYa
D000614:Aminocaproates / Q000627:therapeutic use*; D015119:Aminocaproic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D005260:Female; D009980:Influenza A virus / Q000187:drug effects / Q000472:pathogenicity; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000517:prevention & control*; D013045:Species Specificity
D000614:Aminocaproates; D015119:Aminocaproic Acid