[Effect of a beta 2-blocker on the adrenergic receptors of lymphocytes in hypertension].
A short-term effect of propranolol on beta 2-adrenoceptor density in mononuclear lymphocytes was studied in 15 male patients with essential hypertension. According to receptor density alterations the hypertensive subjects were divided into two groups. In the first group lymphocyte beta 2-receptor density increased substantially (3 times, on the average). Propranolol had a weak antihypertensive effect in this group, with the initially low plasma renin activity remaining unchanged after the treatment. The patients of the second group, on the contrary, revealed features of sympathetic hyperactivity and a decrease (2 times on the average) in lymphocyte beta 2-receptor density. Propranolol administration caused a decline in the initially normal or elevated plasma renin activity as well as in systolic arterial blood pressure and heart rate.
Krasnikova
T L
TL
Radiukhin
V A
VA
Parfenova
E V
EV
Suvorov
Iu I
IuI
Ustinova
S E
SE
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects; D011433:Propranolol / Q000627:therapeutic use; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D011433:Propranolol
Deĭstvie beta 2-blokatora na adrenergicheskie retseptory limfotsitov pri gipertonicheskoĭ bolezni.