Antagonism of non-depolarising neuromuscular blockade by aminopyridines in cats.
The antagonism of pipecuronium- and vecuronium-induced neuromuscular blockade by 4-aminopyridine (4AP), 3,4-diaminopyridine (3,4AP) and 3-[(dimethylamino)-carbonyl] amino-4-aminopyridine (LF14) were studied in anaesthetized cats during constant infusion of the relaxants. Aminopyridines were administered cumulatively at steady state 90% block level. The ED50 values of 4AP, 3,4AP and LF14 were 243, 106 and 254 micrograms kg-1 in pipecuronium, and 232, 195 and 235 micrograms kg-1 in vecuronium blockade. It has been assumed that in cats the anticurare effect of aminopyridines is mainly a result of K+ channel blockade on motor nerve terminals which enhances the evoked release of acetylcholine.
Riesz
M
M
Kápáti
E
E
Szporny
L
L
D015761:4-Aminopyridine / Q000031:analogs & derivatives; D000077770:Amifampridine; D000631:Aminopyridines / Q000494:pharmacology*; D015113:Androstane-3,17-diol / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D000818:Animals; D002415:Cats; D008297:Male; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors*; D010197:Pancuronium / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D017300:Pipecuronium; D010879:Piperazines / Q000037:antagonists & inhibitors; D012584:Sciatic Nerve; D014673:Vecuronium Bromide
D000631:Aminopyridines; D003473:Neuromuscular Nondepolarizing Agents; D010879:Piperazines; D017300:Pipecuronium; D015113:Androstane-3,17-diol; D014673:Vecuronium Bromide; C040030:LF 14; D015761:4-Aminopyridine; D010197:Pancuronium; D000077770:Amifampridine