HPLC analysis of furazolidone in goats given the therapeutic dose.
Furazolidone (FZ) was given to Nubian goats at the recommended therapeutic dose of 10 mg/kg body wt, for 5 days. The animals were slaughtered 24 hr after the last dose, and their livers, gluteal muscles, kidneys and hearts analysed for FZ residues by an HPLC method with a detection limit of 0.05 micrograms g-1. The drug was detected in the muscle and liver at concentrations of 0.256 +/- 0.009, 0.101 +/- 0.016 micrograms g-1 tissue, respectively. No detectable concentrations of the drug were found in the kidney and heart.
Mustafa
A I
AI
Ali
B H
BH
Satti
A M
AM
D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005664:Furazolidone / Q000378:metabolism* / Q000627:therapeutic use; D006041:Goats / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D014018:Tissue Distribution
D005664:Furazolidone