Rationale for and results from a randomised, double-blind trial of tetrachlorodecaoxygen anion complex in wound healing.
Local tetrachlorodecaoxygen anion complex (TCDO) had three therapeutic effects in difficult wounds, substantiated on day 14 in a multicentre double-blind randomised clinical trial on 271 inpatients with 0.9% saline as control. Wound cleansing was intensified, the formation of new tissue (granulations, epithelium) was promoted, and, irrespective of the different wound types, wound surfaces decreased more quickly, by a factor of 2.4. A novel quantity (eta) was derived as an indicator of wound healing promotion. eta NaCl (= -0.14) did not differ among different wound diagnoses. eta TCDO values were significantly better in relation to wound diagnosis, to smear (detritus), and to epithelialisation. Local TCDO was well tolerated.
Hinz
J
J
Hautzinger
H
H
Stahl
K W
KW
D000287:Administration, Topical; D000368:Aged; D001684:Biological Dressings; D002713:Chlorine / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010087:Oxides / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D012044:Regression Analysis; D012883:Skin Ulcer / Q000188:drug therapy; D013530:Surgical Wound Infection / Q000188:drug therapy; D013997:Time Factors; D014647:Varicose Ulcer / Q000188:drug therapy; D014945:Wound Healing / Q000187:drug effects*
D010087:Oxides; D002713:Chlorine; C041955:tetrachlorodecaoxide