title: Neurological control of vasopressin release.
abstract: Vasopressin (VP)-containing neurons of the supraoptic and paraventricular nuclei are influenced by a number of diverse, chemically defined neural systems. Of these the anatomy and physiology of noradrenergic and cholinergic afferents are best understood. Norepinephrine (NE)-containing neurons of the caudal medulla heavily innervate VP neurons; NE has been shown to either inhibit or facilitate the release of VP under different experimental paradigms. Acetylcholine is a powerful stimulant of VP release. gamma-Aminobutyric acid also appears to inhibit release. Several other putative transmitters are localized within the supraoptic and paraventricular nuclei, which suggests that VP release is integrated by a wide variety of neural systems.
authors.forename: J R
authors.initials: JR
authors.lastname: Sladek
authors.forename: C D
authors.initials: CD
authors.lastname: Sladek
mesh_terms: D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D009475:Neurons, Afferent / Q000378:metabolism / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology; D010121:Oxytocin / Q000378:metabolism / Q000502:physiology; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism / Q000502:physiology; D010904:Pituitary Gland, Posterior / Q000502:physiology*; D051381:Rats; D011910:Rats, Brattleboro; D013495:Supraoptic Nucleus / Q000378:metabolism / Q000502:physiology; D014667:Vasopressins / Q000378:metabolism* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D018377:Neurotransmitter Agents; D014667:Vasopressins; D010121:Oxytocin; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine; D009638:Norepinephrine