Effects of amino acid neurotransmitter candidates on an identified insect motoneurone.
The cell body of the fast coxal depressor motoneurone (Df) was used to examine the effects of a group of putative amino acid neurotransmitters. gamma-Aminobutyric acid (GABA) elicited a biphasic hyperpolarizing response, each component having a separate reversal potential. Both components were affected by the GABA antagonist picrotoxinin. L-Glutamate produced a hyperpolarizing response with a reversal potential of between -80 and -85 mV, and L-aspartate gave a similar but less potent effect. Kainic acid and quisqualic acid elicited depolarizing responses of up to 10 mV in amplitude. beta-Alanine and taurine produced a single hyperpolarization with a reversal potential similar to glutamate. Glycine was ineffective on motoneurone Df.
Wafford
K A
KA
Sattelle
D B
DB
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009046:Motor Neurons / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D010526:Periplaneta
D000596:Amino Acids; D018377:Neurotransmitter Agents