The synergistic action of pyrazolopyrimidines and pentavalent antimony against Leishmania donovani and L. braziliensis.
Pyrazolopyrimidines, particularly allopurinol, allopurinol riboside, and other purine analogues, show promise as experimental therapeutic compounds for the treatment of leishmaniasis. The combination of these agents with pentostam may produce an improved therapeutic effect. We report here on strong synergistic activity between pyrazolopyrimidines and pentavalent antimonials in a human macrophage tissue culture system infected with Leishmania donovani and L. braziliensis.
Martinez
S
S
Department of Medicine, University of Cauca, Popoyan, Colombia.
Looker
D L
DL
Berens
R L
RL
Marr
J J
JJ
D000493:Allopurinol / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D000967:Antimony Sodium Gluconate / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002460:Cell Line; D004357:Drug Synergism; D005942:Gluconates / Q000494:pharmacology*; D006801:Humans; D007891:Leishmania / Q000187:drug effects*; D007892:Leishmania braziliensis / Q000187:drug effects*; D007893:Leishmania donovani / Q000187:drug effects*; D008264:Macrophages / Q000469:parasitology; D012263:Ribonucleosides / Q000494:pharmacology
D000981:Antiprotozoal Agents; D005942:Gluconates; D012263:Ribonucleosides; D000493:Allopurinol; D000967:Antimony Sodium Gluconate; C021958:allopurinol riboside