The active principles of the branchlet and hook of Uncaria sinensis Oliv. examined with a 5-hydroxytryptamine receptor binding assay.
Of the alkaloids obtained from Uncaria sinensis Oliv., geissoschizine methyl ether, corynantheine and dihydrocorynantheine decreased specific [3H]5-HT binding to membrane preparations from rat brain and from in-vitro experiments on guinea-pig ileum, these alkaloids were found to be partial agonists for 5-HT receptors. Therefore, they might be useful in the treatment of diseases resulting from disorders of 5-HT metabolism.
Kanatani
H
H
Kohda
H
H
Yamasaki
K
K
Hotta
I
I
Nakata
Y
Y
Segawa
T
T
Yamanaka
E
E
Aimi
N
N
Sakai
S
S
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D010946:Plants, Medicinal / Q000032:analysis*; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*
D000470:Alkaloids; D011985:Receptors, Serotonin