Duodenal somatostatinoma with psammoma bodies: an immunohistochemical and ultrastructural study.
We report a case of malignant somatostatinoma of the ampulla of Vater in a 38-year-old woman with diabetes and cholelithiasis. Immunohistochemistry showed that tumor cells contained only somatostatin and electron microscopy revealed D-type granules in their cytoplasm. Psammoma bodies were numerous and appeared to originate in the cytoplasm of somatostatin producing cells. A review of the literature reveals that somatostatinomas with psammoma bodies are found only in the duodenum and do not produce significant amounts of peptides other than somatostatin.
Taccagni
G L
GL
Carlucci
M
M
Sironi
M
M
Cantaboni
A
A
Di Carlo
V
V
D007516:Adenoma, Islet Cell / Q000473:pathology*; D000328:Adult; D014670:Ampulla of Vater / Q000473:pathology / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004379:Duodenal Neoplasms / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008854:Microscopy, Electron; D013004:Somatostatin / Q000032:analysis* / Q000276:immunology; D013005:Somatostatinoma / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure
D013004:Somatostatin