title: [Changes in the cyclic nucleotide levels during the contraction of smooth muscles exposed to muscarinic cholinomimetics].
abstract: Intracellular levels of cyclic nucleotides AMP and GMP were measured in isolated preparations of the guinea pig ileum, taenia coli, bladder and vas deferens. The cAMP level was about ten-fold as high as the cGMP level. During cholinergic stimulation for 5-10 sec contractile response preceded the cGMP rise. Muscarinic cholinomimetics obviously increased the cGMP levels especially in vas deferens, whereas no significant changes occurred in the cAMP levels. Changes in the cGMP levels were only found during phasic tension of muscles.
authors.forename: A F
authors.initials: AF
authors.lastname: Danilov
authors.forename: L I
authors.initials: LI
authors.lastname: Pershina
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000032:analysis*; D006152:Cyclic GMP / Q000032:analysis*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000032:analysis / Q000187:drug effects*; D010277:Parasympathomimetics / Q000494:pharmacology*; D011863:Radioimmunoassay
chemical_list: D010277:Parasympathomimetics; D000242:Cyclic AMP; D006152:Cyclic GMP
vernacular_title: Izmenenie urovneĭ tsiklicheskikh nukleotidov v protsesse sokrashcheniia gladkikh myshts pri deĭstvii muskarinovykh kholinomimetikov.