title: Thyroid-stimulating immunoglobulins and thyroid function tests in two siblings with neonatal thyrotoxicosis.
abstract: Thyroid function and serum TSI levels in two siblings with neonatal thyrotoxicosis are described. The first infant was treated with exchange transfusion and potassium iodide. The second infant was treated with intrauterine propylthiouracil followed by potassium iodide. In contrast to the first infant, the second infant had no clinical sign of neonatal thyrotoxicosis. He also had lower TSI levels with a biological half-life of 5 days. Only one of three assays showed some TSI activity in breast milk.
authors.forename: J M
authors.initials: JM
authors.lastname: Wit
authors.forename: B
authors.initials: B
authors.lastname: Rees-Smith
authors.forename: F M
authors.initials: FM
authors.lastname: Creagh
authors.forename: H W
authors.initials: HW
authors.lastname: Bruinse
authors.forename: D
authors.initials: D
authors.lastname: van der Heide
authors.forename: R
authors.initials: R
authors.lastname: Docter
authors.forename: L J
authors.initials: LJ
authors.lastname: Gerards
mesh_terms: D000328:Adult; D000906:Antibodies / Q000032:analysis*; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005500:Follow-Up Studies; D006207:Half-Life; D006801:Humans; D006980:Hyperthyroidism / Q000151:congenital* / Q000235:genetics / Q000628:therapy; D007074:Immunoglobulin G / Q000032:analysis*; D018828:Immunoglobulins, Thyroid-Stimulating; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011193:Potassium Iodide / Q000627:therapeutic use; D011247:Pregnancy; D011441:Propylthiouracil / Q000627:therapeutic use; D011956:Receptors, Cell Surface / Q000276:immunology; D011989:Receptors, Thyrotropin; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000276:immunology*; D013997:Time Factors
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G; D018828:Immunoglobulins, Thyroid-Stimulating; D011956:Receptors, Cell Surface; D011989:Receptors, Thyrotropin; D011193:Potassium Iodide; D011441:Propylthiouracil