[Antigenic structure of the foot-and-mouth-disease virus. I. Synthesis of protective peptides from the major immunogenic region of VP1 protein of foot-and-mouth virus type O1K].
A series of overlapping peptides with the sequence of the immunodominant region of VP1 protein of FMDV strain O1K have been synthesized by the classical solution method. Peptides were purified by standard methods and used for immunization of guinea pigs. It is shown that the 136-152 and 136-148 segments provide antiviral protection in guinea pigs, both in the free state and conjugated with an immunogenic carrier. Results with uncoupled peptides indicated that these segments may form not only B-, but also T-cell affecting sites.
Surovoĭ
A Iu
AIu
Vol'pina
O M
OM
Snetkova
E V
EV
Volkova
T D
TD
Ivanov
V T
VT
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D005537:Aphthovirus / Q000276:immunology*; D002851:Chromatography, High Pressure Liquid; D005536:Foot-and-Mouth Disease / Q000517:prevention & control; D006168:Guinea Pigs; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology*; D014764:Viral Proteins / Q000138:chemical synthesis / Q000276:immunology*; D015678:Viral Structural Proteins; D014765:Viral Vaccines
D000956:Antigens, Viral; D010455:Peptides; D014764:Viral Proteins; D015678:Viral Structural Proteins; D014765:Viral Vaccines
Antigennaia struktura virusa iashchura. Sintez protektivnykh peptidov posledovatel'nosti osnovnogo immunogennogo raĭona belka VP1 virusa iashchura shtamma O1K.