[Use of presynaptic alpha-mimetics for withdrawal in heroin addicts].
We report the results of two studies carried out in the Drug Addiction Unit of Fernand-Widal hospital, on the use of presynaptic alpha-mimetic drugs in the treatment of heroin addicts. The authors briefly recall the mode of action of these drugs, and then describe the methodology of these two studies of Guanoxabenz and Guanfacine; characteristics of this group, outcome of therapy, mode of prescription, side effects. The results are analysed and compared with the usual methods of treatment using synthetic opiates.
Gorceix
A
A
Dugarin
J
J
Pommier
F
F
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000328:Adult; D005260:Female; D006143:Guanabenz / Q000031:analogs & derivatives / Q000627:therapeutic use; D016316:Guanfacine; D006146:Guanidines / Q000627:therapeutic use; D006556:Heroin Dependence / Q000534:rehabilitation*; D006760:Hospitalization; D006801:Humans; D007902:Length of Stay; D008297:Male; D010648:Phenylacetates / Q000627:therapeutic use; D012008:Recurrence; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control*; D013997:Time Factors
D000316:Adrenergic alpha-Agonists; D006146:Guanidines; D010648:Phenylacetates; D016316:Guanfacine; D006143:Guanabenz; C028782:guanoxabenz
Utilisation des alpha-mimétiques pré-synaptiques dans le sevrage des héroïnomanes.