[Adult T-cell leukemia and non-Hodgkin's lymphoma in brothers].
Adult T-cell leukemia/lymphoma (ATL) is an endemic disease in the Southwestern districts of Japan. Intrafamilial cluster of ATL and other T-malignancy frequently reported in these area. We reported cases of ATL and non-Hodgkin's lymphoma in brothers, they were born in Hokkaido where is non-endemic area of ATL. The first case (ATL) is 53 y. male and the second case (non-HD), younger brother of the first case, is 55 y male. Anti-ATLA (ATL-virus associated antigen) antibody were positive in both of them, their elder sister, wife and child of the first cases. Examination of anti-ATLA antibody and follow up study is necessary in the family members of ATL, because they may be in a high risk group of ATL outbreak.
Maekawa
I
I
Kawamura
T
T
Miyake
T
T
D000914:Antibodies, Viral / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015480:Deltaretrovirus Antibodies; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000276:immunology; D008223:Lymphoma / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D013601:T-Lymphocytes; D014750:Vincristine / Q000008:administration & dosage
D000914:Antibodies, Viral; D015480:Deltaretrovirus Antibodies; D011344:Procarbazine; D014750:Vincristine; D004317:Doxorubicin; D011239:Prednisolone