Influence of medium polarity on the photosensitizing properties of hematoporphyrin and hematoporphyrin derivative (Photofrin II).
The influence of the polarity of the medium on the efficiency of Type I and Type II photosensitization as carried out by hematoporphyrin and its derivative Photofrin II was studied by EPR techniques. Our results suggest that porphyrin aggregates do not participate as such in the photosensitized processes. Thus, the solvent-induced breakdown of the aggregated components of Photofrin II appears to determine the photosensitizing efficiency of this porphyrin.
Shopova
M
M
Institute of Organic Chemistry, Bulgarian Academy of Sciences, Sofia.
Gantchev
T
T
D017323:Dihematoporphyrin Ether; D004578:Electron Spin Resonance Spectroscopy; D006415:Hematoporphyrins; D007700:Kinetics; D010084:Oxidation-Reduction; D010777:Photochemistry; D010778:Photochemotherapy
D006415:Hematoporphyrins; D017323:Dihematoporphyrin Ether