[Randomized ergometric study of vasodilators combined with betablockaders].
The ergometric effects of different vasodilator drugs in 5 series of 10 patients with stable angina and persistent effort ischaemia despite beta-offckade, were compared two by two in a random, single blind cross-over study under basal conditions on betablocker therapy and at the peak of their action, the second measurement being performed after a 2 to 7 day interval. The principal criteria of assessment were the work required to induce 1 mm ST depression (WST1), and the maximum ST depression (ST max) at comparable work loads. Molsidomine (2 mg), Risordan 20 mg) and Nifedipine (10 mg) significantly improved both parameters (p less than 0.001). Lenitral (7.5 mg), Langoran (40 mg), Trinitrin skin patch (10 mg) did not produce a significant improvement. Corditrine improved WST1 (p less than 0.05) and slow release Trinitrin (2.5 and 5 mg) improved WST1 at 3 hours (p less than 0.05) and ST max at 15 minutes (p less than 0.001) and 3 hours (p less than 0.05). The fall in resting blood pressure was parallel to the ergometric changes. These results suggest that Molsidomine, Nifedipine, Risordan and slow release Trinitrin (2.5 mg) are the most effective vasodilators when used in association with betablockers.
Witchitz
S
S
Kolski
H
H
Moisson
P
P
Yvenou
L
L
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005080:Exercise Test / Q000379:methods; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D008981:Molsidomine; D009543:Nifedipine / Q000008:administration & dosage; D005996:Nitroglycerin / Q000008:administration & dosage; D013558:Sydnones / Q000008:administration & dosage; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D013558:Sydnones; D014665:Vasodilator Agents; D008981:Molsidomine; D005996:Nitroglycerin; D009543:Nifedipine; D007548:Isosorbide Dinitrate
Etude ergométrique randomisée des vasodilatateurs associés aux bêtabloqueurs.