[Effect of benzodiazepines on 5'-nucleotidase activity in rat brain].
Experiments on 330 rats were made to study the influence of benzodiazepines (diazepam, dormicum and phenazepam) on 5'-nucleotidase activity in brain homogenates. It was discovered that diazepam and dormicum in doses of 3 and 4 mg, phenazepam in doses of 3.75 and 5 mg per 200 g bw provoked a 16-20% reduction in 5'-nucleotidase activity. The maximal effect of diazepam (3 and 4 mg doses) was attained 1 h after intraperitoneal injection, that of dormicum (3 mg) 30 min and of phenazepam (5 mg) 1 h after intraperitoneal injection. It is assumed that benzodiazepines are involved in AMP metabolism.
Korotkina
R N
RN
Papin
A A
AA
Karelin
A A
AA
D015720:5'-Nucleotidase; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology; D001570:Benzodiazepinones / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D003864:Depression, Chemical; D003975:Diazepam / Q000494:pharmacology; D008297:Male; D008874:Midazolam; D009708:Nucleotidases / Q000378:metabolism*; D051381:Rats
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D009708:Nucleotidases; D015720:5'-Nucleotidase; D003975:Diazepam; D008874:Midazolam
Izuchenie vliianiia benzodiazepinov na aktivnost' 5'-nukleotidazy golovnogo mozga krys.