title: Growth and sexual development in children with meningomyelocele.
abstract: Forty-five children (25 girls; 20 boys) with meningomyelocele (MMC) were assessed for growth, skeletal maturation and pubertal development. The spinal defects were operated on shortly after birth and all children required cerebral drainage for hydrocephalus. Standard deviation scores for height, sitting height, sub-ischiac leg length, head circumference, weight and bone age were compared with aged-matched data from a normal Swiss population. The children with MMC were shorter (height SDS boys -2.34 +/- 1.57; girls -2.01 +/- 1.57, mean +/- SD, P less than 0.0005), secondary to a decrease in trunk and lower limb length: Arm length was normal. The head circumference was increased, significantly in the girls (SDS + 1.49 +/- 1.21, P less than 0.005). Weight was decreased in both sexes, this being significant in the boys (SDS -1.11 +/- 1.23, P less than 0.005); however, comparison of weight with height suggested that children with MMC were relatively obese. Bone age was significantly advanced in both boys (SDS + 1.07 +/- 2.13, P less than 0.025) and girls (SDS + 1.36 +/- 1.77, P less than 0.0001). Secondary sex characteristics appeared early in both boys and girls and one girl and one boy presented with puberty advanced by several years. Cryptorchidism occurred in 25% of boys with MMC.
authors.forename: S A
authors.initials: SA
authors.lastname: Greene
authors.forename: M
authors.initials: M
authors.lastname: Frank
authors.forename: M
authors.initials: M
authors.lastname: Zachmann
authors.forename: A
authors.initials: A
authors.lastname: Prader
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton; D000886:Anthropometry; D002648:Child; D002675:Child, Preschool; D003456:Cryptorchidism / Q000150:complications; D005260:Female; D006128:Growth; D006801:Humans; D008297:Male; D008591:Meningomyelocele / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D011627:Puberty; D012741:Sexual Maturation