Neuromuscular blocking action of vecuronium in the dog and its reversal by neostigmine.
Vecuronium bromide is one of a new series of competitive or nondepolarising muscle relaxants which is closely related chemically to pancuronium. Doses of 0.06, 0.1 and 0.2 mg kg-1 produced neuromuscular block in the anaesthetised dog. There were no observable effects on arterial blood pressure. The neuromuscular block was readily reversible with neostigmine preceded by atropine.
Jones
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D000704:Analysis of Variance; D000768:Anesthesia, General / Q000662:veterinary*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004336:Drug Antagonism; D004558:Electric Stimulation; D007275:Injections, Intravenous / Q000662:veterinary; D009119:Muscle Contraction / Q000187:drug effects; D009388:Neostigmine / Q000494:pharmacology*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects; D010197:Pancuronium / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D014673:Vecuronium Bromide
D009466:Neuromuscular Blocking Agents; D009388:Neostigmine; D001285:Atropine; D014673:Vecuronium Bromide; D010197:Pancuronium