Acute haemodynamic effects and tissue distribution of acebutolol in normotensive and spontaneously hypertensive rats.
Acute i.v. administration of 15 mg/kg acebutolol in normotensive (WKY), Okamoto (SHR) and Okamoto stroke-prone (SHR-SP) awake rats resulted in weak effects on blood pressure and in bradycardia more marked in SHR-SP. Thirty minutes after i.v. administration, lung and renal uptake of [14C]acebutolol was reduced in SHR compared to other rats. Muscle uptake was higher in SHR and blood concentration was higher in SHR-SP. Brain levels were low and similar in all rats. Plasma protein binding was identical in all rats. These results are discussed according to the characteristics of the three strains studied.
Midol-Monnet
M
M
Heimburger
M
M
Davy
M
M
Beslot
F
F
Wepierre
J
J
Cohen
Y
Y
Barre
J
J
D000070:Acebutolol / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000033:anatomy & histology; D006321:Heart / Q000033:anatomy & histology; D006439:Hemodynamics / Q000187:drug effects*; D007668:Kidney / Q000033:anatomy & histology; D009929:Organ Size / Q000187:drug effects; D011485:Protein Binding; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*; D014018:Tissue Distribution
D001798:Blood Proteins; D000070:Acebutolol