The biological activity of duck 'big' somatostatin on chicken adipose tissue.
A peptide, eluted with cytochrome c, called 'big' somatostatin, is the only somatostatin-like immunoreactivity present in the peripheral plasma of the duck. The metabolic action of partially purified fractions of 'big' somatostatin was investigated on glucagon-stimulated lipolysis in chicken adipocytes. Significant inhibition of glycerol release (an index of lipolysis) induced by physiological concentrations of glucagon was observed with physiological concentrations of 'big' somatostatin; the percentage of inhibition was dose-dependent.
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D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D002645:Chickens / Q000378:metabolism*; D004372:Ducks / Q000097:blood*; D005934:Glucagon / Q000494:pharmacology; D005990:Glycerol / Q000378:metabolism; D008066:Lipolysis / Q000187:drug effects*; D013004:Somatostatin / Q000494:pharmacology*
D013004:Somatostatin; D005934:Glucagon; D005990:Glycerol