Prostaglandin D2-induced potentiation of hexobarbitone hypnosis in rats: role of 5-hydroxytryptamine.
Prostaglandin D2 (PGD2) produced a dose-related increase in the duration and incidence of induction of sleep induced by hexobarbitone, in rats. Pretreatment with pharmacological agents known to reduce selectively brain 5-hydroxytryptaminergic activity, significantly inhibited PGD2-induced potentiation of hexobarbitone, indicating that this potentiation is mediated by 5-hydroxytryptamine.
Bhattacharya
S K
SK
Parmar
S S
SS
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006591:Hexobarbital / Q000494:pharmacology*; D006993:Hypnotics and Sedatives; D007276:Injections, Intraventricular; D008297:Male; D015230:Prostaglandin D2; D011457:Prostaglandins D / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*
D006993:Hypnotics and Sedatives; D011457:Prostaglandins D; D012701:Serotonin; D006591:Hexobarbital; D015230:Prostaglandin D2