title: Beta-lactam resistance mechanisms in gram-negative bacteria.
abstract: Beta-lactam antibiotics are commonly used to treat a variety of bacterial infections. Gram-negative bacteria have evolved several resistance mechanisms including altered permeability and beta-lactamase production. New trends in resistance are emerging amongst clinical isolates which may reflect the choice of beta-lactam employed.
authors.affiliation: Unité des Applications du Génie Génétique, Institute Pasteur, Paris, France.
authors.forename: S T
authors.initials: ST
authors.lastname: Cole
authors.forename: M H
authors.initials: MH
authors.lastname: Nicolas
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002463:Cell Membrane Permeability; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000378:metabolism; D047090:beta-Lactams
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams