Antiarrhythmic action and protection of ischaemia myocardium after beta-blockade with bevantolol.
In the present study 12 of 13 untreated pigs died of ventricular fibrillation during three 10 min episodes of left anterior descending coronary artery occlusion interrupted by 20 min of reperfusion. The selective beta-adrenoceptor antagonist bevantolol in a dose of 1.5 mg X kg-1, but not 0.5 mg X kg-1, offered nearly complete protection against this fatal arrhythmia. Evidence is also presented that bevantolol enhanced the recovery of regional myocardial function after these ischaemic events.
Verdouw
P D
PD
Van Bremen
R H
RH
Verkeste
C M
CM
Van der Giessen
W J
WJ
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000818:Animals; D000889:Anti-Arrhythmia Agents; D003327:Coronary Disease / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects; D011412:Propanolamines / Q000494:pharmacology* / Q000627:therapeutic use; D013552:Swine; D014693:Ventricular Fibrillation / Q000517:prevention & control
D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D011412:Propanolamines; C021148:bevantolol