Felodipine can replace minoxidil in the treatment of refractory hypertension.
In a group of 15 men with severe hypertension in a double-blind crossover trial, the new calcium antagonist felodipine has been shown to lower blood pressure as effectively as minoxidil when used in combination with a beta-blocker and a loop diuretic. Felodipine was well tolerated and may have a role in the management of severe hypertension.
MacLeod
D
D
Department of Medicine, Royal Infirmary, Edinburgh, Scotland, UK.
Wathen
C G
CG
Tucker
L
L
Forret
E A
EA
Hill
T W
TW
Muir
A L
AL
D000368:Aged; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D015736:Felodipine / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008914:Minoxidil / Q000627:therapeutic use*
D008914:Minoxidil; D015736:Felodipine