Feasibility of prenatal diagnosis of beta-thalassaemia with synthetic DNA probes in two Mediterranean populations.
A feasibility study in two Mediterranean populations showed that prenatal diagnosis of beta-thalassaemia with a limited number of synthetic oligonucleotide probes would have been possible in about 70% of cases. To provide a comprehensive programme of prenatal diagnosis for the thalassaemias it would be necessary, in most populations, to combine fetal DNA analysis with fetal blood sampling and globin-chain synthesis studies.
Thein
S L
SL
Wainscoat
J S
JS
Old
J M
JM
Sampietro
M
M
Fiorelli
G
G
Wallace
R B
RB
Weatherall
D J
DJ
D001345:Autoradiography; D001483:Base Sequence; D003535:Cyprus; D005260:Female; D005813:Genes, Synthetic; D005914:Globins / Q000235:genetics*; D006801:Humans; D007558:Italy; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000235:genetics*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013789:Thalassemia / Q000175:diagnosis* / Q000235:genetics
D009841:Oligonucleotides; D005914:Globins