Hypokalemia from beta 2-receptor stimulation by circulating epinephrine.
Beta 2-receptor stimulation is required for catecholamine-induced hypokalemia to occur. This hypokalemia is not mediated by insulin, renin or aldosterone. Catecholamine-induced hypokalemia can be prevented by selective beta 2 blockade, which does not abolish the inotropic effect of epinephrine.
Brown
M J
MJ
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000502:physiology; D004077:Digoxin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000097:blood / Q000494:pharmacology / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced / Q000503:physiopathology*; D007328:Insulin / Q000097:blood; D007545:Isoproterenol / Q000494:pharmacology; D009203:Myocardial Infarction / Q000097:blood; D005082:Physical Exertion; D011188:Potassium / Q000097:blood*; D011412:Propanolamines / Q000494:pharmacology; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D007328:Insulin; D011412:Propanolamines; C026777:ICI 118551; D004077:Digoxin; D007545:Isoproterenol; D011188:Potassium; D004837:Epinephrine