title: Influence of H2 receptors blockade upon some central effects of prostacyclin in rats.
abstract: Prostacyclin (PGI2) administered icv into the lateral rat brain ventricle in a dose of 1 and 10 micrograms caused hypothermia and catalepsy. Joint administration of PGI2 and chlorpromazine produced a greater cataleptic effect than that observed after the neuroleptic alone. Cimetidine (CMT) 2 g/kg po administered 60 min before PGI2 icv injection inhibited hypothermic and cataleptogenic action of PGI2. CMT blocked the cataleptogenic effect of chlorpromazine as well as combination of it with PGI2. CMT inhibited cataleptogenic effect of haloperidol, but it did not block the catalepsy induced by joint administration of haloperidol and PGI2. PGI2 did not change concentration of noradrenaline and dopamine in different brain areas. The results indicate that H2 receptors take part in some central pharmacological effects of PGI2 in rats.
authors.forename: R
authors.initials: R
authors.lastname: Brus
authors.forename: T
authors.initials: T
authors.lastname: Krzemiński
authors.forename: Z
authors.initials: Z
authors.lastname: Juraszczyk
authors.forename: A
authors.initials: A
authors.lastname: Kurcok
authors.forename: W
authors.initials: W
authors.lastname: Felińska
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002375:Catalepsy / Q000139:chemically induced; D002746:Chlorpromazine / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D011464:Epoprostenol / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006635:Histamine H2 Antagonists; D002927:Cimetidine; D011464:Epoprostenol; D002746:Chlorpromazine; D004298:Dopamine; D009638:Norepinephrine