Effects of clorazepate dipotassium and placebo on psychomotor skills.
24 normal, healthy subjects were assigned randomly to 15 mg clorazepate dipotassium or placebo groups in a double-blind study. Their performance on a psychological test battery was assessed 45 min. later. Clorazepate dipotassium produced statistically significant impairment in attention and simple reaction time compared with placebo. Performance on more complex tests of cognitive functioning showed no drug effects.
Moodley
P
P
Golombok
S
S
Lader
M
M
D000328:Adult; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D001288:Attention / Q000187:drug effects; D003009:Clorazepate Dipotassium / Q000009:adverse effects*; D003071:Cognition / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010364:Pattern Recognition, Visual / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects*; D011897:Random Allocation
D014151:Anti-Anxiety Agents; D003009:Clorazepate Dipotassium