title: Indoxyl derivatives of drug metabolites.
abstract: Indoxyl derivatives were detected as minor products among the urinary metabolites of two trial drugs, a benzodiazepine (GP 55 129) and a benzophenone (CGP 11 952). Their structures were elucidated by NMR and mass spectroscopy. Presumably, metabolites containing potential aldehyde functions react spontaneously with endogenous indoxyl. Such derivatives have not hitherto been encountered in drug metabolism.
authors.forename: J W
authors.initials: JW
authors.lastname: Faigle
authors.forename: H
authors.initials: H
authors.lastname: Stierlin
authors.forename: H
authors.initials: H
authors.lastname: Mory
authors.forename: T
authors.initials: T
authors.lastname: Winkler
authors.forename: H P
authors.initials: HP
authors.lastname: Kriemler
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000652:urine; D001569:Benzodiazepines / Q000652:urine*; D001577:Benzophenones / Q000652:urine*; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D007211:Indoles / Q000652:urine*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051381:Rats
chemical_list: D014151:Anti-Anxiety Agents; D001577:Benzophenones; D007211:Indoles; D001569:Benzodiazepines; C034082:indoxyl; C044664:CGP 11952; C038305:GP 55129