title: Superfractionated radiotherapy in grade III, IV intracranial gliomas.
abstract: Preliminary results of superfractionation in the treatment of glioblastoma led to a randomized trial consisting of 76 patients. All patients received whole brain irradiation followed by a 1000 cGy boost to the primary site. Thirty-four patients received standard daily treatment to 4000 cGy, whereas 42 patients received superfractionated radiation, treating three times a day to a total dose of 4760 cGy. No significant difference was found between the 5-year survival of the superfractionated group and the standard treatment group. Early reactions were greater for superfractionation whereas late effects were less.
authors.affiliation: Division of Radiation Oncology, Cancer Control Agency of British Columbia, Vancouver, Canada.
authors.forename: C M
authors.initials: CM
authors.lastname: Ludgate
authors.forename: B G
authors.initials: BG
authors.lastname: Douglas
authors.forename: P F
authors.initials: PF
authors.lastname: Dixon
authors.forename: P
authors.initials: P
authors.lastname: Steinbok
authors.forename: S M
authors.initials: SM
authors.lastname: Jackson
authors.forename: G B
authors.initials: GB
authors.lastname: Goodman
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002986:Clinical Trials as Topic; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D011879:Radiotherapy Dosage; D011897:Random Allocation