[Evaluation of the effect of the antihistaminic preparations dimebon and diprazin on embryogenesis in rats].
A single administration of dimebon (800 mg/kg) to rats per os (2/3 of the LD50 isoeffective for females) raises the preimplantation death, whereas pipolphen increases the intrauterine lethality and inhibits the development of fetuses. Pipolphen in a dose of 175 mg/kg and dimebon in doses of 300-150 mg/kg (exceeding 25- and 300-150-fold, respectively, the therapeutic dose for man) do not exert any specific embryotropic action.
Proĭnova
V A
VA
Golovanova
I V
IV
Golubeva
M I
MI
Shashkina
L F
LF
D000818:Animals; D004305:Dose-Response Relationship, Drug; D047108:Embryonic Development / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D006634:Histamine H1 Antagonists / Q000633:toxicity*; D007211:Indoles / Q000633:toxicity*; D011247:Pregnancy; D011398:Promethazine / Q000633:toxicity*; D051381:Rats; D013997:Time Factors
D006634:Histamine H1 Antagonists; D007211:Indoles; D011398:Promethazine; C010119:latrepirdine
Otsenka vliianiia antigistaminnykh preparatov dimebona i diprazina na émbriogenez krys.