C-Alkylpiperazines structurally related to piribedil. XI.
The synthesis of a new series of 1-alkoxybenzyl-4-(2-pyrimidyl)piperazines 2-methyl or 2,6-dimethyl substituted, related to piribedil, is described. Besides compounds (IV)-(IX a, b), the isomer (XI) of (V) was also prepared. Central dopaminergic and alpha-blocking activities both in vitro and in vivo were determined for all compounds. Derivatives (IV), (VII), (XI) were also studied for peripheral vasodilator and sympatholytic activities.
Sanna
P
P
Loriga
M
M
Cignarella
G
G
Ferni
G
G
D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis; D000818:Animals; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D006614:Hindlimb / Q000098:blood supply; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010879:Piperazines / Q000138:chemical synthesis*; D010891:Piribedil / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D013565:Sympatholytics / Q000138:chemical synthesis; D014665:Vasodilator Agents / Q000138:chemical synthesis
D000317:Adrenergic alpha-Antagonists; D010879:Piperazines; D013565:Sympatholytics; D014665:Vasodilator Agents; D010891:Piribedil