title: Delayed response deficit in monkeys by locally disturbed prefrontal neuronal activity by bicuculline.
abstract: Effects of local injection of a gamma-aminobutyric acid antagonist, bicuculline (10-30 micrograms dissolved in saline) in the principal prefrontal cortex on the delayed response task were investigated in two monkeys. On a visual Go signal, the monkeys rotated a handle to the left or to the right (Go period) according to a visual cue (left or right; 1 s) presented 4 s earlier. Bicuculline induced bursting activity at the injected site 1-2 min after the injection and 5 min later the burst activity spread to nearby cortical areas (less than 4 mm diameter). Within 5 min after injection, the monkeys showed errors in Go periods, rotating the handle to the contralateral zone, regardless of the cue side. This tendency continued for 30-40 min and returned to the control level. Electromyographic recordings of forearm muscles did not show any changes. The effect was observed when the drug was injected into a circumscribed area of the bottom of the mid-principalis region. It appears that disturbed neuronal activity in a small group of cortical columns induces performance errors of specific direction of the delayed response.
authors.affiliation: Department of Neurophysiology, Kyoto University, Aichi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sawaguchi
authors.forename: M
authors.initials: M
authors.lastname: Matsumura
authors.forename: K
authors.initials: K
authors.lastname: Kubota
mesh_terms: D000818:Animals; D001288:Attention / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D004292:Dominance, Cerebral / Q000187:drug effects; D005625:Frontal Lobe / Q000187:drug effects*; D008251:Macaca; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D009949:Orientation / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects*; D011963:Receptors, GABA-A / Q000187:drug effects*
chemical_list: D011963:Receptors, GABA-A