Tumorigenic potential of a myc-containing strain of feline leukemia virus in vivo in domestic cats.
The oncogenic capacity of a myc-containing strain of feline leukemia virus (FeLV), termed LC-FeLV, has been examined after inoculation of the virus into neonatal kittens. Like other myc-containing strains of FeLV, LC-FeLV may induce with relatively short latency, but does not necessarily induce, thymic lymphosarcoma in viremic animals. Naturally occurring and experimentally induced tumors are T-cell lymphomas which contain clonally integrated LC-FeLV proviral DNA and which cannot readily be cultivated in vitro in the presence or absence of exogenously supplied interleukin-2. Acquisition of myc by FeLV decreases the period of latency before the appearance of tumors but does not expand the spectrum of tumors induced by FeLV alone.
Levy
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Department of Microbiology and Immunology, Tulane Medical Center, New Orleans, Louisiana 70112.
Fish
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Baskin
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D000818:Animals; D000831:Animals, Newborn; D015139:Blotting, Southern; D002371:Cat Diseases / Q000209:etiology*; D002415:Cats; D004279:DNA, Viral / Q000032:analysis; D005256:Leukemia Virus, Feline / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000662:veterinary*; D016274:Oncogene Protein p55(v-myc); D011533:Proviruses / Q000235:genetics; D012191:Retroviridae Proteins / Q000235:genetics*; D013601:T-Lymphocytes; D013953:Thymus Neoplasms / Q000209:etiology / Q000662:veterinary*; D014766:Viremia / Q000662:veterinary
D004279:DNA, Viral; D016274:Oncogene Protein p55(v-myc); D012191:Retroviridae Proteins