Cerebrospinal fluid homovanillic acid and hypokinetic side effects of neuroleptics.
Eleven psychotic patients treated with neuroleptics for 1 month showed a relatively poor response, more side effects, and a no-tolerance pattern with respect to cerebrospinal fluid (CSF) homovanillic acid (HVA). Within this group the severity of neuroleptic catatonia and Parkinsonian side effects was positively associated with an increase in CSF HVA turnover during the treatment period.
Bowers
M B
MB
D000109:Acetylcholine / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D002389:Catatonia / Q000134:cerebrospinal fluid / Q000139:chemically induced*; D002746:Chlorpromazine / Q000009:adverse effects; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006220:Haloperidol / Q000009:adverse effects; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D010302:Parkinson Disease, Secondary / Q000134:cerebrospinal fluid / Q000139:chemically induced*; D010648:Phenylacetates / Q000134:cerebrospinal fluid*
D014150:Antipsychotic Agents; D010648:Phenylacetates; D006220:Haloperidol; D000109:Acetylcholine; D002746:Chlorpromazine; D004298:Dopamine; D006719:Homovanillic Acid