title: Drug modulation of superoxide anion production from human neutrophils.
abstract: The effects of drugs on the production of superoxide anion from neutrophils stimulated by N-formylmethionyl-leucyl-phenylalanine (FMLP) were examined. Drugs acting on specific receptors, such as beta-adrenergic agonists (e.g. fenoterol, salbutamol) inhibited FMLP-evoked superoxide in a dose-dependent fashion. The order of activity: isoprenaline greater than fenoterol greater than salbutamol is the same as that found by assaying their effects on lysosomal enzyme release. Superoxide production from human neutrophils can also be affected in different manners, such as by a scavenging mechanism. A new non-steroidal anti-inflammatory drug, imidazole 2-hydroxybenzoate, by forming complexes with copper, displayed a significant superoxide dismutase activity which would contribute to explain its anti-inflammatory effect in vivo.
authors.forename: R
authors.initials: R
authors.lastname: Fantozzi
authors.forename: S
authors.initials: S
authors.lastname: Brunelleschi
authors.forename: P
authors.initials: P
authors.lastname: Cremonesi
authors.forename: P G
authors.initials: PG
authors.lastname: Pagella
authors.forename: D
authors.initials: D
authors.lastname: Ciani
authors.forename: G C
authors.initials: GC
authors.lastname: Sportoletti
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000420:Albuterol / Q000494:pharmacology; D005280:Fenoterol / Q000494:pharmacology; D006801:Humans; D007093:Imidazoles; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D012459:Salicylates / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism*
chemical_list: D000318:Adrenergic beta-Agonists; D007093:Imidazoles; D012459:Salicylates; D013481:Superoxides; D005280:Fenoterol; C043292:imidazole-2-hydroxybenzoate; D009240:N-Formylmethionine Leucyl-Phenylalanine; D007545:Isoproterenol; D000420:Albuterol