title: Causal relationship between the transitions in the core and the surface in porcine low-density lipoproteins.
abstract: Two independent parameters, two characteristic temperatures, one indicating the change in the molecular organization of the core, Tc, and the other in the surface layer, Ts, were measured for a number of natural and triglyceride-enriched porcine low-density lipoprotein (LDL1 (buoyant density 1.020--1.063 g/ml) and LDL2 (buoyant density 1.063--1.080 g/ml) samples. Tc was determined by differential scanning calorimetry (DSC), whereas Ts was measured by Mn(II) binding to the lipoprotein surface followed by electron spin resonance (ESR) spectroscopy. A significant causal relationship between Tc and Ts in both LDL subfractions demonstrates the surface-core interaction in LDL. The significance of that interaction is emphasized as a possible link in the chain diet----lipoprotein changes----atherosclerosis.
authors.affiliation: Faculty of Pharmacy and Biochemistry, University of Zagreb, Yugoslavia.
authors.forename: J N
authors.initials: JN
authors.lastname: Herak
authors.forename: G
authors.initials: G
authors.lastname: Pifat
authors.forename: J
authors.initials: J
authors.lastname: Brnjas-Kraljevic
authors.forename: G
authors.initials: G
authors.lastname: Lipka
authors.forename: K
authors.initials: K
authors.lastname: Müller
authors.forename: G
authors.initials: G
authors.lastname: Knipping
mesh_terms: D000818:Animals; D002152:Calorimetry, Differential Scanning; D004578:Electron Spin Resonance Spectroscopy; D008077:Lipoproteins, LDL / Q000097:blood*; D013552:Swine; D013696:Temperature; D014280:Triglycerides / Q000097:blood
chemical_list: D008077:Lipoproteins, LDL; D014280:Triglycerides