title: Defective jejunal brush-border Na+/H+ exchange: a cause of congenital secretory diarrhoea.
abstract: In a child with congenital secretory diarrhoea, jejunal perfusion studies showed net water and electrolyte secretion and suggested a defect in sodium/proton exchange. A technique was developed for investigation of such exchange in brush-border membrane vesicles from jejunal biopsy specimens. Vesicles from control specimens displayed proton-gradient-dependent sodium uptake, whereas those from the patient did not. These findings, as well as pointing to a cause of congenital secretory diarrhoea, confirm the existence and importance of jejunal sodium/proton exchange in man.
authors.forename: I W
authors.initials: IW
authors.lastname: Booth
authors.forename: G
authors.initials: G
authors.lastname: Stange
authors.forename: H
authors.initials: H
authors.lastname: Murer
authors.forename: T R
authors.initials: TR
authors.lastname: Fenton
authors.forename: P J
authors.initials: PJ
authors.lastname: Milla
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000151:congenital / Q000378:metabolism*; D005260:Female; D006801:Humans; D006859:Hydrogen / Q000378:metabolism*; D007223:Infant; D007231:Infant, Newborn; D007583:Jejunum / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
chemical_list: D006859:Hydrogen; D012964:Sodium