Tuberohypophyseal and tuberoinfundibular dopamine systems exhibit differential sensitivity to neonatal monosodium glutamate treatment.
The arcuate nucleus (AN) is the presumed origin of the dopaminergic innervation of posterior lobe of the pituitary. Posterior lobe dopamine levels were determined in rats that had been neonatally treated with monosodium glutamate (MSG) to lesion the AN. MSG-induced AN damage was confirmed neurochemically, histologically and immunocytochemically. MSG treatment resulted in a substantial loss of AN neurons and approximately a 50% loss of dopamine uptake capacity (Vmax) in the mediobasal hypothalamus. Posterior pituitary dopamine levels were not significantly altered by MSG-induced AN damage. These results suggest that MSG treatment spares the tuberohypophyseal dopamine system and that the AN may not be the sole origin of the dopaminergic innervation of the posterior pituitary.
Dawson
R
R
Valdes
J J
JJ
Annau
Z
Z
D000818:Animals; D000831:Animals, Newborn; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D005971:Glutamates / Q000633:toxicity*; D010904:Pituitary Gland, Posterior / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D012970:Sodium Glutamate / Q000633:toxicity*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D005971:Glutamates; D011954:Receptors, Dopamine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine; D012970:Sodium Glutamate