title: Malignant round cell tumor of bone with neural differentiation (neuroectodermal tumor).
abstract: A malignant round cell tumor primary in bone is reported in a young girl, showing histologically rosette formation and pseudoalveolar spaces. Vimentin, NSE, and S-100 were positive. Electron microscopy demonstrated abundant glycogen and neural features such as cell processes, microtubules, and occasional dense-core granules. Whether this neuroectodermal tumor represents a separate entity or is a variant of Ewing's sarcoma should wait for further experience, in the light of recent evidence suggesting that Ewing's sarcoma arises from primitive multipotential cells.
authors.affiliation: Department of Pathology, Hospital for Joint Diseases-Orthopedic Institute, New York, New York 10003.
authors.forename: G C
authors.initials: GC
authors.lastname: Steiner
authors.forename: S
authors.initials: S
authors.lastname: Graham
authors.forename: M M
authors.initials: MM
authors.lastname: Lewis
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000032:analysis* / Q000145:classification / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009373:Neoplasms, Germ Cell and Embryonal / Q000032:analysis* / Q000145:classification / Q000648:ultrastructure; D009447:Neuroblastoma / Q000032:analysis / Q000145:classification / Q000648:ultrastructure; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis*; D012512:Sarcoma, Ewing / Q000032:analysis* / Q000145:classification / Q000648:ultrastructure
chemical_list: D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase