Introduction of anaesthesia in caesarean section by using ketamine and fazadinium.
The evaluated data of the anaesthesia protocols of 91 caesarean sections are presented. The narcosis of caesarean sections was introduced by using 1 mg/kg ketamine. Relaxation was achieved by administration of 1 mg/kg fazadinium. To maintain anaesthesia, fentanyl or repeated doses of histamine, were used after removal of the fetus. Anaesthesia was adequate in each case, the patients were amnesic concerning the operation. They recovered well. During anaesthesia, circulation was characterized by the elevation of pulse rate and of systolic pressure. The mean value of the above parameters kept on differing significantly from the initial values throughout the anaesthesia. However, the extent of increase had not reached the difference observed by other authors. The method is considered to be safe and easy to perform since ketamine and fazadinium are anaesthetics well adaptable for use just in this sort of patient material. The analgetic, anaesthetic and amnestic effect of ketamine is fairly good. It does not generally produce circulatory depression rather acts inversely. It does not depress the vital functions of the fetus either and, at the same time, due to its long action, it provides adequate anaesthesia for prolonged removals as well. The rapidly acting fazadinium produces fast relaxation similar to that produced by succinylcholine, while its effect is not associated with the side-effects of the former agent, i.e. hyperkalaemia, fasciculations. As a result of the latter, it is a useful aid in preventing the always threatening aspiration in the anaesthesia of caesarean sections.
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D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical; D001794:Blood Pressure / Q000187:drug effects; D002585:Cesarean Section; D005260:Female; D006801:Humans; D007649:Ketamine; D008875:Middle Aged; D011247:Pregnancy; D011674:Pulse / Q000187:drug effects; D011726:Pyridinium Compounds
D011726:Pyridinium Compounds; D007649:Ketamine