The "Pardridge" hypotheses relating to the role of hormone binding proteins in hormone delivery: a critique.
Though the physiological role of specific binding proteins in serum is unknown, and the validity of the "free hormone hypothesis" has been challenged by several authors (including ourselves), we regard Pardridge's widely publicised objections to this hypothesis (and his recent suggestion of the existence of complex biochemical mechanisms causing the release of individual hormones in particular tissues) as deriving from an incorrect analysis of the effects of serum binding proteins on the kinetics of hormone transport, and therefore without foundation. This presentation is intended to substantiate this view.
Edwards
P
P
Department of Molecular Endocrinology, Middlesex Hospital Medical School, University of London, UK.
Ekins
R
R
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006728:Hormones / Q000008:administration & dosage*; D011956:Receptors, Cell Surface / Q000378:metabolism*
D006728:Hormones; D011956:Receptors, Cell Surface