Somatostatin: a metabolic regulator.
Somatostatin, the hypothalamic release-inhibiting factor, has been found to stimulate gluconeogenesis in rat kidney cortical slices. Stimulation by somatostatin was linear and dose-dependent. Other bioactive peptides such as cholecystokinin, gastrointestinal peptide, secretin, neurotensin, vasoactive intestinal peptide, pancreatic polypeptide, beta endorphin and substance P did not affect the renal gluconeogenic activity. Somatostatin-induced gluconeogenesis was blocked by phentolamine (alpha adrenergic antagonist) and prazosin (alpha1 adrenergic antagonist) but not by propranolol (beta adrenergic antagonist) and yohimbine (alpha2 adrenergic antagonist) suggesting that the effect is via alpha1 adrenergic stimuli. Studies on the involvement of Ca2+ revealed that tissue depletion and omission of Ca2+ from the reaction mixture would abolish the stimulatory effect of somatostatin. Furthermore, somatostatin enhanced the uptake of 45calcium in renal cortical slices which could be blocked by lanthanum, an inhibitor of Ca2+ influx. It is proposed that the stimulatory effect of somatostatin on renal gluconeogenesis is mediated by alpha1 adrenergic receptors, or those which functionally resemble alpha1 receptors and that the increased influx of Ca2+ may be the causative factor for carrying out the stimulus.
Dileepan
K N
KN
Wagle
S R
SR
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D001646:Bile / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D002118:Calcium / Q000502:physiology; D000242:Cyclic AMP / Q000096:biosynthesis; D004068:Digestive System Physiological Phenomena; D005934:Glucagon / Q000378:metabolism; D005943:Gluconeogenesis / Q000187:drug effects; D006003:Glycogen / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007672:Kidney Cortex / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism; D011224:Prazosin / Q000494:pharmacology; D011388:Prolactin / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D013004:Somatostatin / Q000502:physiology*; D013972:Thyrotropin / Q000378:metabolism; D015016:Yohimbine / Q000494:pharmacology
D001639:Bicarbonates; D001786:Blood Glucose; D007328:Insulin; D011773:Pyruvates; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D015016:Yohimbine; D013004:Somatostatin; D019289:Pyruvic Acid; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D006003:Glycogen; D005934:Glucagon; D000242:Cyclic AMP; D002118:Calcium; D011224:Prazosin