The NMDA receptor: central role in pain inhibition in rat periaqueductal gray.
An injection of the excitatory amino acid analogue, N-methyl-D-aspartate (NMDA), in the rat periaqueductal gray resulted in potent analgesia. A prior injection of the NMDA antagonist, (-)-2-amino-7-phosphonoheptanoate (D-AP7), antagonized this action, indicating a receptor-mediated action. NMDA given with morphine potentiated the morphine analgesia while D-AP7 blocked morphine analgesia. These results delineate for the first time a functional role for the NMDA receptor in the control of pain in the mammalian central nervous system.
Jacquet
Y F
YF
Nathan Kline Institute, Orangeburg, NY 10962.
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000596:Amino Acids / Q000494:pharmacology; D000698:Analgesia; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology; D016202:N-Methylaspartate; D010069:Oxadiazoles / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology*; D010487:Periaqueductal Gray / Q000187:drug effects / Q000503:physiopathology*; D016318:Quisqualic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000502:physiology*
D000596:Amino Acids; D010069:Oxadiazoles; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D001224:Aspartic Acid; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; D009020:Morphine; D016318:Quisqualic Acid; C031231:2-amino-7-phosphonoheptanoic acid; D007608:Kainic Acid