[Arachidonic acid metabolites, leukotrienes--mediators of hypersensitivity and inflammation].
A problem of leukotrienes--metabolites of arachidonic acid is reviewed in immunological aspects. Their nomenclature is given; basic pathways of biosynthesis, transformation and mode of leukotriens participation in hypersensitivity and inflammatory reactions are considered. The possibility of application of leukotrienes antagonists and inhibitors of their formation for allergic diseases treatment is discussed.
Konyshev
V A
VA
Marokko
I N
IN
Shaternikov
V A
VA
D000818:Animals; D000941:Antigens / Q000276:immunology; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004357:Drug Synergism; D006168:Guinea Pigs; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D007249:Inflammation / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000276:immunology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D011817:Rabbits; D011971:Receptors, Immunologic / Q000378:metabolism; D013189:SRS-A / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000276:immunology*; D013329:Structure-Activity Relationship; D009626:Terminology as Topic; D013928:Thromboxane A2 / Q000096:biosynthesis
D000941:Antigens; D001095:Arachidonic Acids; D018377:Neurotransmitter Agents; D011971:Receptors, Immunologic; D013189:SRS-A; D007975:Leukotriene B4; D013928:Thromboxane A2
Metabolity arakhidonovoĭ kisloty leĭkotrieny--mediatory giperchuvstvitel'nosti i vospaleniia.