The non-benzodiazepine anxiolytic buspirone inhibits stress-induced renin secretion and lowers heart rate.
The non benzodiazepine drug, buspirone, produces a dose-dependent biphasic effect on plasma renin activity in non-stressed rats. Low doses (0.1 - 2.0 mg/kg i.p.) decrease while high doses (10.0 - 50.0 mg/kg i.p.) increase plasma renin activity. The maximal decrease in plasma renin activity produced by buspirone (1.0 mg/kg i.p.) was observed 30 minutes post-injection. In addition, buspirone (0.5 and 2.0 mg/kg i.p.) blocked the stress-induced rise in plasma renin activity. This effect of buspirone is in contrast to the previously observed failure of the benzodiazepine anxiolytics to alter the effect of stress on plasma renin activity. Administration of buspirone (0.5 mg/kg i.p.) produced a sustained reduction (15%) in heart rate but did not affect mean arterial pressure. The present data support the view that the mechanism of the anxiolytic action of buspirone is different from that of the benzodiazepines.
Van de Kar
L D
LD
Urban
J H
JH
Lorens
S A
SA
Richardson
K D
KD
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002065:Buspirone; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood / Q000378:metabolism*; D013312:Stress, Physiological / Q000201:enzymology / Q000503:physiopathology*
D014151:Anti-Anxiety Agents; D011743:Pyrimidines; D012083:Renin; D002065:Buspirone