[Hypotensive effect of dinitrosyl iron complexes in experiments on waking animals].
Changes in arterial pressure evoked by dinitrosyl iron complexes (DNIC) were studied in conscious normotensive (Wistar) and spontaneously hypertensive (SHR) rats. Doses from 1 to 10 mcM/kg of DNIC evoked dose-dependent decrease in blood pressure for two hours. SHR rats were more sensitive to the effect of the drug than normotensive Wistar rats. Long-lasting effects of the drug depended on the NO-stores, which were DNIC with paired RS-(-)groups of proteins. These complexes measured with EPR method were formed as a result of Fe(NO)2 groups transfer from injected low molecular weight DNIC to protein RS-(-)groups.
Galagan
M E
ME
Oranovskaia
E V
EV
Mordvintsev
P I
PI
Medvedev
O S
OS
Vanin
A F
AF
D000818:Animals; D000959:Antihypertensive Agents / Q000032:analysis / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004578:Electron Spin Resonance Spectroscopy; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007501:Iron / Q000032:analysis / Q000627:therapeutic use*; D008024:Ligands; D008297:Male; D009589:Nitrogen Oxides / Q000032:analysis / Q000627:therapeutic use*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D012996:Solutions; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations; D008024:Ligands; D009589:Nitrogen Oxides; D012996:Solutions; D007501:Iron
Gipotenzivnyĭ éffekt dinitrozil'nykh kompleksov zheleza v opytakh na bodrstvuiushchikh zhivotnykh.