[Quantitative evaluation of the anxiolytic and nootropic effects of potassium orotate in a wide range of doses].
Chronic administration of potassium orotate to rats per os in doses of 5, 10, 20, 50 and 100 mg/kg was followed by different correlations of the training under stress with anxiolytic activity. The doses of the drug were defined, at which the maximally pronounced effects under consideration were in optimal correlations, as were doses which entailed inhibition of the training in the presence of a relatively low tranquilizing activity, low emotional responsiveness and aggressiveness. It is suggested that natural analogs of pyrimidine, whose precursor is orotic acid, are universal endogenous regulators of mnemonic and antianxiety functions.
Karkishchenko
N N
NN
Khaĭtin
M I
MI
D000818:Animals; D014151:Anti-Anxiety Agents; D003214:Conditioning, Classical / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006613:Higher Nervous Activity / Q000187:drug effects; D007858:Learning / Q000187:drug effects; D008297:Male; D009963:Orotic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D011188:Potassium / Q000008:administration & dosage / Q000494:pharmacology*; D011619:Psychotropic Drugs; D051381:Rats
D014151:Anti-Anxiety Agents; D011619:Psychotropic Drugs; D009963:Orotic Acid; D011188:Potassium
Kolichestvennaia otsenka anksioliticheskogo i nootropnogo éffektov kaliia orotata v shirokim diapazone doz.