title: Rapid diagnostic test for ocular adenovirus.
abstract: A new, direct, enzyme immunoassay test (Adenoclone, Cambridge BioScience, Hopkinton, MA) was evaluated for the rapid diagnosis of ocular adenovirus infections. In 36 culture-proven cases of adenovirus ocular infection, direct Adenoclone testing of conjunctival swabs was positive in 24 of 31 patients (77%) tested within 1 week of onset of symptoms, and in one of five patients (20%) who presented after 1 week (P less than 0.02). Overall sensitivity was 69%, whereas specificity was 100%. The authors conclude that a positive Adenoclone test is reliable in the rapid diagnosis of early adenovirus ocular infections.
authors.affiliation: Charles T. Campbell Microbiological Laboratory, Department of Ophthalmology, University of Pittsburgh, PA 15213.
authors.forename: L
authors.initials: L
authors.lastname: Wiley
authors.forename: D
authors.initials: D
authors.lastname: Springer
authors.forename: R P
authors.initials: RP
authors.lastname: Kowalski
authors.forename: R
authors.initials: R
authors.lastname: Arffa
authors.forename: M I
authors.initials: MI
authors.lastname: Roat
authors.forename: R A
authors.initials: RA
authors.lastname: Thoft
authors.forename: Y J
authors.initials: YJ
authors.lastname: Gordon
mesh_terms: D000257:Adenoviridae Infections / Q000175:diagnosis*; D000258:Adenovirus Infections, Human / Q000175:diagnosis*; D005069:Evaluation Studies as Topic; D005128:Eye Diseases / Q000175:diagnosis*; D006801:Humans; D011933:Reagent Kits, Diagnostic / Q000592:standards; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D011933:Reagent Kits, Diagnostic