[Existence and function of a receptor for immunoglobulin A on human eosinophils].
The existence of receptors for immunoglobulin A on human eosinophils is demonstrated by flow cytofluorometry. Between 5 and 60% of eosinophils purified from peripheral blood of hypereosinophilic patients are able to bind monomeric serum IgA. The addition of antihuman IgA antibodies to surface IgA-bearing eosinophils induces the exocytosis of peroxidase contained in the granules suggesting a cell activation due to IgA receptors. The inhibition of antiparasitic cytotoxicity by eosinophils preincubated with IgA under a polymeric form only, indicates the low affinity of IgA receptors as well as their participation in the effector function of eosinophils.
Capron
M
M
Unité Mixte I.N.S.E.R.M., U 167-C.N.R.S., Institut Pasteur, Lille.
Tomassini
M
M
Van der Vorst
E
E
Kusnierz
J P
JP
Papin
J P
JP
Capron
A
A
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000502:physiology; D000911:Antibodies, Monoclonal; D003602:Cytotoxicity, Immunologic; D004804:Eosinophils / Q000276:immunology*; D005089:Exocytosis; D005434:Flow Cytometry; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology / Q000378:metabolism; D009195:Peroxidase / Q000097:blood; D011961:Receptors, Fc; D011971:Receptors, Immunologic / Q000032:analysis* / Q000276:immunology; D012550:Schistosoma mansoni / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; C045281:IgA receptor; D007070:Immunoglobulin A; D011961:Receptors, Fc; D011971:Receptors, Immunologic; D009195:Peroxidase
Existence et fonctions d'un récepteur pour l'immunoglobuline A sur les éosinophiles humains.