Role of endogenous prostaglandins in somatostatin-induced inhibition of gastrointestinal hormone secretion.
Endogenous prostaglandins have been reported to be essential for the inhibitory effect of somatostatin on acid secretion. From these results it could be suggested that the effect of somatostatin on the secretion of gastroentero-pancreatic hormones may also be medulated by prostaglandins. This hypothesis was investigated in man and in the rat. Somatostatin-induced inhibition of postprandial gastrin, cholecystokinin, pancreatic polypeptide, and insulin release was not influenced by indomethacin pretreatment in healthy subjects. Using the isolated perfused rat stomach preparation, inhibition of acetylcholine-stimulated gastrin secretion by somatostatin was found to be unchanged by indomethacin treatment. It is concluded that endogenous prostaglandins are unlikely to be indispensable for the inhibitory effect of somatostatin on gastroentero-pancreatic endocrine cells.
Koop
H
H
Schwarz
C
C
Koop
I
I
Dionysius
J
J
Mönnikes
H
H
Arnold
R
R
D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002766:Cholecystokinin / Q000378:metabolism; D003864:Depression, Chemical; D005755:Gastrins / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D010191:Pancreatic Polypeptide / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000494:pharmacology*
D001786:Blood Glucose; D005755:Gastrins; D005768:Gastrointestinal Hormones; D007328:Insulin; D011453:Prostaglandins; D013004:Somatostatin; D010191:Pancreatic Polypeptide; D002766:Cholecystokinin; D007213:Indomethacin