The effect of lithium on the renal response to the dopamine prodrug gludopa in normal man.
1. The effect of oral lithium on the renal response to gamma-L-glutamyl-L-dopa (gludopa, 25 micrograms kg-1 min-1) was investigated in seven normal males. 2. Gludopa at this dose produced an 800-fold increase in urine dopamine excretion. It was natriuretic and suppressed plasma renin activity without altering blood pressure and pulse. 3. Lithium alone increased sodium excretion and stimulated plasma renin activity. However, it abolished the natriuresis produced by gludopa. 4. Gludopa did not significantly affect lithium clearance. 5. This study suggests that lithium interacts with dopamine at the proximal tubule and that the lithium clearance method is not suitable for investigating dopaminergic mechanisms in the kidney.
Jeffrey
R F
RF
Department of Clinical Pharmacology, Royal Infirmary, Edinburgh.
Macdonald
T M
TM
Brown
J
J
Rae
P W
PW
Lee
M R
MR
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood; D000242:Cyclic AMP / Q000097:blood; D004295:Dihydroxyphenylalanine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D004298:Dopamine / Q000009:adverse effects / Q000494:pharmacology* / Q000652:urine; D004347:Drug Interactions; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008094:Lithium / Q000097:blood / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011355:Prodrugs; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood
D011355:Prodrugs; C017342:gamma-glutamyl DOPA; D004295:Dihydroxyphenylalanine; D009320:Atrial Natriuretic Factor; D008094:Lithium; D012964:Sodium; D000242:Cyclic AMP; D012083:Renin; D004298:Dopamine