Superfractionated radiotherapy in grade III, IV intracranial gliomas.
Preliminary results of superfractionation in the treatment of glioblastoma led to a randomized trial consisting of 76 patients. All patients received whole brain irradiation followed by a 1000 cGy boost to the primary site. Thirty-four patients received standard daily treatment to 4000 cGy, whereas 42 patients received superfractionated radiation, treating three times a day to a total dose of 4760 cGy. No significant difference was found between the 5-year survival of the superfractionated group and the standard treatment group. Early reactions were greater for superfractionation whereas late effects were less.
Ludgate
C M
CM
Division of Radiation Oncology, Cancer Control Agency of British Columbia, Vancouver, Canada.
Douglas
B G
BG
Dixon
P F
PF
Steinbok
P
P
Jackson
S M
SM
Goodman
G B
GB
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002986:Clinical Trials as Topic; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D011879:Radiotherapy Dosage; D011897:Random Allocation