title: [Protective effect of adrenergic alpha 2-receptor agonists in hypoxic hypoxia].
abstract: The antihypoxic effect of alpha 2-adrenoceptor agonists was studied by two different approaches: reproduction of the effect by a number of alpha 2-agonists and its blockade with selective antagonists. The data obtained suggest that alpha 2-adrenoceptor agonists increase the survival and the lifespan of mice in all the models of acute hypoxic hypoxia under study. A close correlation between antihypoxic action of alpha 2-adrenoceptor agonists and their anticalorigenic effect was established (r = +0.87; P less than 0.01).
authors.forename: V I
authors.initials: VI
authors.lastname: Kulinskiĭ
authors.forename: I A
authors.initials: IA
authors.lastname: Ol'khovskiĭ
authors.forename: A N
authors.initials: AN
authors.lastname: Kovalevskiĭ
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D005260:Female; D000860:Hypoxia / Q000503:physiopathology / Q000517:prevention & control*; D051379:Mice; D010101:Oxygen Consumption / Q000187:drug effects; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*
chemical_list: D000316:Adrenergic alpha-Agonists; D011942:Receptors, Adrenergic, alpha
vernacular_title: Zashchitnoe deĭstvie agonistov alpha 2-adrenoretseptorov pri gipoksicheskoĭ gipoksii.