title: Actinomycin D and cycloheximide actions on activity of some intestinal enzymes of adult hamster.
abstract: Actinomycin D, at a dose of 0.25 micrograms/g body wt, produced slight increases in intestinal enzymatic activity on hamsters. At a high dose (1.5 micrograms/g body wt), actinomycin D produced inhibition of lactase activity, whereas maltase, sucrase and alkaline phosphatase activity decreased in males and increased in females. Cycloheximide (1.5 micrograms/g body wt), produced no changes in enzymatic activity. In the male and female hamster, the different actions of the antibiotic can be explained by the variations in the cortisol release produced by stress.
authors.forename: M D
authors.initials: MD
authors.lastname: Andrés
authors.forename: E
authors.initials: E
authors.lastname: Rebolledo
authors.forename: M C
authors.initials: MC
authors.lastname: Taboada
authors.forename: M P
authors.initials: MP
authors.lastname: Fernandez Otero
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D006224:Cricetinae; D003513:Cycloheximide / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology*; D005260:Female; D007421:Intestine, Small / Q000201:enzymology*; D007700:Kinetics; D008297:Male; D013393:Sucrase / Q000378:metabolism; D000520:alpha-Glucosidases / Q000378:metabolism; D001616:beta-Galactosidase / Q000378:metabolism
chemical_list: D003609:Dactinomycin; D003513:Cycloheximide; D000469:Alkaline Phosphatase; D000520:alpha-Glucosidases; D001616:beta-Galactosidase; D013393:Sucrase