Effects of varying fat content of a high tryptophan diet on the induction of gamma-glutamyltranspeptidase positive foci in the livers of rats treated with hepatocarcinogen.
The influence of varying the dietary fat content on the emergence of gamma-glutamyltranspeptidase (GGT)-positive foci in the livers of male rats fed elevated (2%) L-tryptophan (TRP) and exposed to a hepatocarcinogen was investigated. Subtotal hepatectomies were performed, and 18 h later the rats were treated with diethylnitrosamine (DEN) (30 mg/kg). Ten days later 4 dietary groups were followed for 10 weeks: (1) control diet containing 15% fat (C-HF); (2) control diet containing 5% fat (C-LF); (3) C-HF + TRP; (4) C-LF + TRP. Rats fed elevated TRP diets (C-HF + TRP and C-LF + TRP) similarly developed more and larger GGT+ foci than did rats fed the regular TRP diets (C-HF and C-LF), indicating that the promotional effect of elevated dietary TRP was not affected by the fat level (15% vs. 5%).
Sidransky
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H
Verney
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Wang
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D
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D004052:Diethylnitrosamine / Q000633:toxicity*; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000201:enzymology; D008115:Liver Regeneration; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014364:Tryptophan / Q000494:pharmacology*; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D004041:Dietary Fats; D004052:Diethylnitrosamine; D014364:Tryptophan; D005723:gamma-Glutamyltransferase