Enzymuria of the rat: biorhythms and sex differences.
Alanine aminopeptidase, gamma-glutamyltransferase and N-acetyl-beta-D-glucosaminidase were measured daily over 65 days in 24-hour urine of male and female Wistar rats. The mathematical evaluation was based on the Fourier-analysis. The excretion of alanine aminopeptidase and gamma-glutamyltransferase was higher in male than in female rats. This sex-dependent difference was not observed for N-acetyl-beta-D-glucosaminidase. The excretion of the 3 enzymes followed a biorhythm with a dominant period of 7 days for gamma-glutamyltransferase and N-acetyl-beta-D-glucosaminidase and one of 9 days for alanine aminopeptidase. Biorhythms and sex differences of enzymuria should be considered in experimental designs.
Grötsch
H
H
Hropot
M
M
Klaus
E
E
Malerczyk
V
V
Mattenheimer
H
H
D000118:Acetylglucosaminidase / Q000652:urine; D000626:Aminopeptidases / Q000652:urine; D000818:Animals; D001835:Body Weight; D018826:CD13 Antigens; D002940:Circadian Rhythm; D003404:Creatinine / Q000652:urine; D004798:Enzymes / Q000502:physiology / Q000652:urine*; D005260:Female; D005583:Fourier Analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics; D005723:gamma-Glutamyltransferase / Q000652:urine
D004798:Enzymes; D003404:Creatinine; D005723:gamma-Glutamyltransferase; D000118:Acetylglucosaminidase; D000626:Aminopeptidases; D018826:CD13 Antigens