Adenylate cyclase and alpha-2-adrenoceptors in thrombocytes of chronic uremic patients.
Thrombocyte adenylate cyclase regulation and alpha-2-adrenoceptors have been studied in uremic patients as well as in healthy controls. Stimulation of adenylate cyclase activity by PGE1 and forskolin as well as inhibition by (+/-)-epinephrine was not significantly different between both groups. Additionally, there was no evidence of an alteration of the thrombocyte alpha-2-adrenoceptor density, determined by 3H-rauwolscine binding as suggested by others.
Lübbecke
F
F
Center of Internal Medicine, Justus Liebig University, Giessen, FRG.
Sandelbaum
J
J
Schütterle
G
G
Wizemann
V
V
D000262:Adenylyl Cyclases / Q000032:analysis / Q000097:blood*; D000328:Adult; D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D014511:Uremia / Q000097:blood*
D011942:Receptors, Adrenergic, alpha; D000262:Adenylyl Cyclases