title: Common DNA polymorphism within coding sequence of apolipoprotein B gene associated with altered lipid levels.
abstract: 60 of 83 middle-aged white men had an XbaI restriction site polymorphism within the coding sequence of the apolipoprotein B gene. Subjects homozygous and heterozygous for the presence of an XbaI restriction site had mean serum triglyceride levels 36% higher (p = 0.02) than those in homozygotes without the restriction site; there was a less substantial difference (p = 0.03) in serum cholesterol. The findings supported a dominant pattern of inheritance. The presence of this restriction site may increase the risk of atherosclerotic disease.
authors.forename: A
authors.initials: A
authors.lastname: Law
authors.forename: S C
authors.initials: SC
authors.lastname: Wallis
authors.forename: L M
authors.initials: LM
authors.lastname: Powell
authors.forename: R J
authors.initials: RJ
authors.lastname: Pease
authors.forename: H
authors.initials: H
authors.lastname: Brunt
authors.forename: L M
authors.initials: LM
authors.lastname: Priestley
authors.forename: T J
authors.initials: TJ
authors.lastname: Knott
authors.forename: J
authors.initials: J
authors.lastname: Scott
authors.forename: D G
authors.initials: DG
authors.lastname: Altman
authors.forename: G J
authors.initials: GJ
authors.lastname: Miller
mesh_terms: D001055:Apolipoproteins B / Q000235:genetics*; D001161:Arteriosclerosis / Q000235:genetics; D001483:Base Sequence; D002784:Cholesterol / Q000097:blood*; D004247:DNA / Q000032:analysis*; D004262:DNA Restriction Enzymes; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk; D014280:Triglycerides / Q000097:blood*
chemical_list: D001055:Apolipoproteins B; D014280:Triglycerides; D004247:DNA; D002784:Cholesterol; D004262:DNA Restriction Enzymes