Immunological activities of multiprenylacetyl derivatives of muramyldipeptides.
The immunological properties of six kinds of multiprenylacetic acids and six kinds of multiprenylacetyl muramyldipeptide (MDP) derivatives were examined by using experimental models in mice and guinea-pigs. All the multiprenylacetyl MDP derivatives, particularly TMD-232, showed potent adjuvant activity on the circulating antibody formation against bacterial alpha-amylase in mice, and induction of delayed-type hypersensitivity to monoazobenzenearsonate N-acetyl-L-tyrosine in guinea-pigs. All multiprenylacetic acid preparations tested in this study, however, showed no adjuvant activity in these immune systems. Both TMD-17 and TMD-232 entrapped into multilamellar vesicles showed potent host stimulation activity against Sendai virus infection in mice.
Azuma
I
I
Institute of Immunological Science, Hokkaido University, Sapporo, Japan.
Saiki
I
I
Iida
J
J
Fukuda
T
T
Kobayashi
S
S
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives / Q000276:immunology*; D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D008297:Male; D051379:Mice; D018184:Paramyxoviridae Infections / Q000276:immunology; D014443:Tyrosine / Q000031:analogs & derivatives / Q000276:immunology; D000516:alpha-Amylases / Q000276:immunology; D010132:p-Azobenzenearsonate / Q000031:analogs & derivatives / Q000276:immunology
D000276:Adjuvants, Immunologic; C000234:azobenzenearsonate-N-acetyl-L-tyrosine; D014443:Tyrosine; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D010132:p-Azobenzenearsonate; D000516:alpha-Amylases