[Mechanism of the radioprotective effect of catecholamine receptor agonists. Inclusion in the radioprotective effect of both subtypes of alpha-adrenoreceptors].
alpha-Adrenoceptor agonists of both main groups, i. e. arylalkylamines and imidazolines, have a pronounced radioprotective effect. Their chemical analogs, which fail to stimulate alpha-adrenoceptors, do not protect mice. The effect of phenylephrine, adrenaline, and noradrenaline comes into play via alpha 1-adrenoceptors and that of clonidine, via alpha 2-adrenoceptors and also via alpha 1-adrenoceptors. Adrenoceptor agonists can probably manifest their radioprotective action via both subtypes of alpha-adrenoceptors. Possible intracellular mechanisms of the radioprotective action are discussed.
Kulinskiĭ
V I
VI
Klimova
A D
AD
IashunskiI
V G
VG
Alpatova
T V
TV
D000322:Adrenergic Agonists / Q000627:therapeutic use*; D000818:Animals; D003000:Clonidine / Q000627:therapeutic use; D004837:Epinephrine / Q000627:therapeutic use; D005260:Female; D007093:Imidazoles / Q000627:therapeutic use; D051379:Mice; D009278:Naphazoline / Q000627:therapeutic use; D009638:Norepinephrine / Q000627:therapeutic use; D010656:Phenylephrine / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine
D000322:Adrenergic Agonists; D007093:Imidazoles; D011837:Radiation-Protective Agents; D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine; D010656:Phenylephrine; D009278:Naphazoline; D003000:Clonidine; C009695:xylometazoline; D009638:Norepinephrine; D004837:Epinephrine
Issledovanie mekhanizmov radiozashchitnogo éffekta agonistov katekholaminovykh retseptorov. Vkliuchenie v radiozashchitnyĭ éffekt oboikh podtipov al'fa-adrenoretseptorov.