title: Production of insulin-like growth factor binding protein(s) (IGF-BPs) by human placenta: variation with gestational age.
abstract: Preterm human placentae produce insulin-like growth factor- (IGF-)specific binding protein(s). Competitive binding experiments revealed at least two distinct, high-affinity binding sites for IGF-I and IGF-II. Gel permeation chromatography and sodium dodecyl sulphate-polyacrylamide gel electrophoresis analysis of the binding protein(s) suggested that they possess a molecular weight in the 45 to 50 kD range. In contrast, term placental tissue produced almost no detectable binding protein activity.
authors.affiliation: Department of Pediatrics, Harvard Medical School, Boston, MA.
authors.forename: M
authors.initials: M
authors.lastname: Fant
authors.forename: H
authors.initials: H
authors.lastname: Munro
authors.forename: A C
authors.initials: AC
authors.lastname: Moses
mesh_terms: D003513:Cycloheximide / Q000494:pharmacology; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008970:Molecular Weight; D009924:Organ Culture Techniques; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism*; D017451:Receptors, Somatomedin; D013002:Somatomedins / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface; D017451:Receptors, Somatomedin; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D003513:Cycloheximide