Adrenoceptor and imipramine receptor binding during the menstrual cycle.
The binding characteristics of platelet alpha 2-adrenoceptors, lymphocyte beta 2-adrenoceptors and platelet imipramine receptors were studied in five women during their menstrual cycle. A significant cyclic variation in the number of beta 2-adrenoceptor sites on intact lymphocytes was found during the menstrual cycle, while binding to alpha 2-adrenoceptors and imipramine receptors remained unchanged.
Stowell
L I
LI
Neurological Research Group, Wellington School of Medicine, New Zealand.
McIntosh
C J
CJ
Cooke
R
R
Ellis
P M
PM
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D002352:Carrier Proteins; D004088:Dihydroergotoxine / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics; D008214:Lymphocytes / Q000378:metabolism; D008597:Menstrual Cycle; D010869:Pindolol / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D011869:Radioligand Assay; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D002352:Carrier Proteins; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D004088:Dihydroergotoxine; C047975:cyanopindolol; D010869:Pindolol; D007099:Imipramine