title: Prevention of deep venous thrombosis in vascular surgical procedures by LMW-heparin.
abstract: The risk of Deep Venous Thrombosis (DVT) in the immediate postoperative period varies from 0.8 to 96% of cases depending on major or minor operations and on age of patients. We have employed 8,000 I.U. AXa/daily of LMW-Heparin injected subcutaneously from one day preoperatively and prolonged for 8 days after surgical procedures in 40 patients operated upon by an aorto-femoral bypass in 25 cases, a femoro-popliteal below the knee in 8 and an extra-anatomical bypass in 7. The onset of DVP in the lower limbs was investigated by clinical examination, venous Doppler pressure evaluation, waveform analysis and echotomography and the 125I-Fibrinogen uptake test. There was no intraoperative increased bleeding and the preclotting of the prosthetic grafts was inaffected. A DVT was detected during the second postoperative day, by means of the 125I-Fibrinogen test in the calf of only one patient (1/40-2.5%), submitted to an aorto-bifemoral bypass, in whom the clinical pattern and ultrasound investigations were negative. The single daily subcutaneous administration has never caused side effects in the site of injection and it seems a real improvement in the heparin treatment. These results emphasize the advantage of the use of LMW-Heparins in patients submitted to arterial surgical reconstructions of the lower limbs for the prevention of the DVT.
authors.affiliation: La Sapienza University, Rome, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Gossetti
authors.forename: L
authors.initials: L
authors.lastname: Irace
authors.forename: R
authors.initials: R
authors.lastname: Gattuso
authors.forename: F
authors.initials: F
authors.lastname: Intrieri
authors.forename: A
authors.initials: A
authors.lastname: Aracu
authors.forename: F
authors.initials: F
authors.lastname: Ciocca
authors.forename: P
authors.initials: P
authors.lastname: Marini
authors.forename: R
authors.initials: R
authors.lastname: Massa
authors.forename: F
authors.initials: F
authors.lastname: Benedetti-Valentini
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D002986:Clinical Trials as Topic; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D007866:Leg / Q000098:blood supply; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D012307:Risk Factors; D013924:Thrombophlebitis / Q000517:prevention & control*
chemical_list: D006495:Heparin, Low-Molecular-Weight