Localization of stage-specific embryonic antigens in hydatidiform mole, normal placenta, and gestational choriocarcinoma.
Murine stage-specific embryonic antigens (SSEA-1, SSEA-3) are well characterized oncofetal antigens and have been identified in several human tumors. The current study was undertaken to determine the localization of SSEA-1 and SSEA-3 in hydatidiform mole, normal human placenta, and gestational choriocarcinoma. SSEA-3 did not react with any cellular components in hydatidiform moles, normal placentas, or choriocarcinoma cell lines. SSEA-1 was detectable in two human gestational choriocarcinoma cell lines, but not in the trophoblastic cells of 10 hydatidiform moles or in nine normal placentas between 6 weeks and term gestation. Therefore, according to this oncofetal marker system, the trophoblast in hydatidiform mole is more like normal trophoblast than gestational choriocarcinoma.
Berkowitz
R S
RS
Alberti
O
O
Hunter
N J
NJ
Goldstein
D P
DP
Anderson
D J
DJ
D000951:Antigens, Neoplasm / Q000032:analysis*; D002460:Cell Line; D002822:Choriocarcinoma / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D005865:Gestational Age; D006017:Glycolipids / Q000032:analysis*; D006651:Histocytochemistry; D006801:Humans; D006828:Hydatidiform Mole / Q000276:immunology; D007124:Immunoenzyme Techniques; D016256:Lewis X Antigen; D008198:Lymph Nodes / Q000276:immunology; D009367:Neoplasm Staging / Q000379:methods; D010920:Placenta / Q000276:immunology* / Q000473:pathology; D011247:Pregnancy; D012306:Risk; D014328:Trophoblastic Neoplasms / Q000276:immunology* / Q000473:pathology; D014327:Trophoblasts / Q000276:immunology; D014594:Uterine Neoplasms / Q000276:immunology* / Q000473:pathology
D000951:Antigens, Neoplasm; D006017:Glycolipids; D016256:Lewis X Antigen; C031192:oncofetal antigens