title: Study of five haemogenetic markers (Gc, C3, Bf, Ag, and GALT) in six Indonesian populations and in 12 subgroups of Balinese.
abstract: In various ethnic groups of the Indonesian archipelago and of Bali, the polymorphisms of the serum proteins Gc globulin (vitamin D-binding protein), C3 (complement component 3), Bf (complement factor B), Ag x,y (lipoprotein allotypes), and of the red cell enzyme system GALT (galactose-1P-uridyltransferase) were analysed. Among the studied proteins, the Gc system was the most informative one for the anthropologist. Besides considerable differences of frequencies of the common alleles Gc*1F, Gc*1S and Gc*2, a number of rare alleles (1A1, 1A3, 1A8, 1A9, 1A12, 1C2, 1C21, 1C24, and 2C8) and some new ones (1C28, 1C29, 1C30, 2C9) were observed. The presence of Gc*1A1 demonstrates the relationship to the Australo-Melanesian populations, but Mongolian variants (1A3, 1A8, 1A9, 1C2) were also encountered. Within the C3 system a very high frequency of the C3*S allele was observed in all populations. The rare alleles C3*F0.55, C3S1, and C3*S0.5 were observed in some groups. A new allele (C3*F0.35) was detected in a Chinese individual and in a nobleman from Bali. The frequency of the Bf*F allele was rather low in general, and the Bf*S0.7 allele was found in three Indonesian individuals only. The Ag*(x) frequencies were rather high, as it is known for Asiatic populations. Variability among subgroups was not very pronounced. The GALT*2 allele (Duarte variant of the enzyme) was observed very rarely; however, it was present in several populations. Enzyme activities could not be determined, and therefore we cannot tell whether the galactosaemia gene (GALT*0) was present or not.
authors.affiliation: Central Laboratory, Blood Transfusion Service, Bern, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Scherz
authors.forename: G
authors.initials: G
authors.lastname: Breguet
authors.forename: R
authors.initials: R
authors.lastname: Ney
authors.forename: R
authors.initials: R
authors.lastname: Pflugshaupt
authors.forename: R
authors.initials: R
authors.lastname: Bütler
mesh_terms: D003176:Complement C3 / Q000235:genetics; D003165:Complement System Proteins / Q000235:genetics*; D004912:Erythrocytes / Q000201:enzymology*; D005819:Genetic Markers / Q000032:analysis / Q000097:blood; D005828:Genetics, Population; D006801:Humans; D007214:Indonesia; D008077:Lipoproteins, LDL / Q000097:blood / Q000235:genetics*; D009713:Nucleotidyltransferases / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D044469:Racial Groups / Q000235:genetics*; D006599:UDPglucose-Hexose-1-Phosphate Uridylyltransferase / Q000097:blood / Q000235:genetics*; D014809:Vitamin D-Binding Protein / Q000097:blood / Q000235:genetics*
chemical_list: D003176:Complement C3; D005819:Genetic Markers; D008077:Lipoproteins, LDL; D014809:Vitamin D-Binding Protein; D003165:Complement System Proteins; D009713:Nucleotidyltransferases; D006599:UDPglucose-Hexose-1-Phosphate Uridylyltransferase