Myasthenia gravis and polymyositis in a dog following fetal hematopoietic cell transplantation.
Myasthenia gravis and focal polymyositis occurred in a dog following successful transplantation of DLA-identical fetal liver hematopoietic cells. There was no evidence of acute or chronic graft-versus-host disease. Antibodies to acetylcholinesterase receptor and immune complexes reactive with myoneural junctions were demonstrated, as well as focal inflammation with perifascicular and type 2 muscle atrophy. The dog responded to treatment with prednisolone and pyridostigmine.
Cain
G R
GR
Cardinet
G H
GH
Cuddon
P A
PA
Gale
R P
RP
Champlin
R
R
D000818:Animals; D000906:Antibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D004285:Dogs; D005260:Female; D005333:Fetus; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000276:immunology; D008099:Liver / Q000166:cytology; D008297:Male; D009132:Muscles / Q000473:pathology; D009157:Myasthenia Gravis / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D009220:Myositis / Q000209:etiology* / Q000276:immunology; D009469:Neuromuscular Junction / Q000276:immunology; D011828:Radiation Chimera; D014181:Transplantation Immunology; D014184:Transplantation, Homologous / Q000009:adverse effects; D014611:Vaccination / Q000009:adverse effects
D000906:Antibodies