[cAMP-dependent phosphorylation inhibits potential-dependent passive transport of Ca2+ in myometrial sarcolemma vesicles].
It is established that Ca2+ transport from the predominantly inverted vesicles of pig myometrium sarcolemma depends on the value of the membrane potential which is created on vesicles by the K+-valinomycin system. It is shown that variations in the membrane potential from -60 to +30 mV cause acceleration of the calcium transport from the vesicles, the maximal transport being observed at delta psi from 0 up to +30 mV. The endogenic and exogenic cAMP-dependent phosphorylation of plasma membrane proteins inhibits the passive transport of calcium at all the membrane potential values studied. A degree of potential-dependent Ca2+ transport inhibition correlates with the value of cAMP-dependent phosphorylation of sarcolemma proteins.
Kurskiĭ
M D
MD
Babich
L G
LG
Kondratiuk
T P
TP
Bychenok
S F
SF
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D000242:Cyclic AMP / Q000502:physiology*; D005260:Female; D005456:Fluorescent Dyes; D007700:Kinetics; D008564:Membrane Potentials; D009215:Myometrium / Q000378:metabolism*; D010766:Phosphorylation; D012508:Sarcolemma / Q000378:metabolism*; D013552:Swine
D005456:Fluorescent Dyes; D000242:Cyclic AMP; D002118:Calcium
tsAMP-zavisimoe fosforilirovanie ingibiruet potentsialzavisimyĭ passivnyĭ transport Ca2+ v vezikulalk sarkolemmy miometriia.