title: Na+/Ca2+ antiports in membranes of rat incisor odontoblasts.
abstract: When incubated in the presence of Na+ ions, dissected rat incisor odontoblasts extruded Ca2+ ions, as detected by tetracycline fluorimetry. Also odontoblast mitochondria, obtained by subcellular fractionation and monitored by ion-specific mini-electrode technique, were found to extrude Ca2+ upon addition of Na+ ions. These findings demonstrate the presence of Na+/Ca2+ antiports in the odontoblast plasma membrane as well as in the odontoblast mitochondrial inner membrane. In addition, evidence was found for an ATP-dependent Ca2+ ion extrusion across the plasma membrane in these cells.
authors.affiliation: Department of Oral Biochemistry, Faculty of Odontology, Gothenburg University, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Lundgren
authors.forename: A
authors.initials: A
authors.lastname: Linde
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000493:pharmacokinetics; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D002751:Chlortetracycline; D005453:Fluorescence; D007180:Incisor; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D009804:Odontoblasts / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000494:pharmacology; D015222:Sodium Channels / Q000187:drug effects / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D015222:Sodium Channels; D000255:Adenosine Triphosphate; D012964:Sodium; D002118:Calcium; D002751:Chlortetracycline