Evidence for HTLV-I associated with mycosis fungoides and B-cell chronic lymphocytic leukemia.
Human T-cell lymphotropic virus type I (HTLV-I) is a human retrovirus that can transform T-helper lymphocytes and is etiologically associated with adult T-cell lymphoma/leukemia. Mycosis fungoides represents a primary cutaneous lymphoma of helper T-cell origin, while chronic lymphocytic leukemia is generally considered to be a neoplastic B-lymphocyte disorder. Our patient had HTLV-I with coexistent mycosis fungoides and B-cell chronic lymphocytic leukemia. The concurrent lymphoid proliferations may represent HTLV-I-associated abnormalities of immunoregulation.
Peterman
A
A
Jerdan
M
M
Staal
S
S
Bender
B
B
Striecher
H
H
Schüpbach
J
J
Resnick
L
L
D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis*; D001402:B-Lymphocytes; D017977:Deltaretrovirus / Q000276:immunology*; D015480:Deltaretrovirus Antibodies; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications / Q000382:microbiology*; D008297:Male; D009182:Mycosis Fungoides / Q000150:complications / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D012867:Skin / Q000276:immunology / Q000382:microbiology / Q000473:pathology
D000914:Antibodies, Viral; D015480:Deltaretrovirus Antibodies