Effect of sodium azide and sodium selenite on prostaglandin synthesis in rabbit kidney medulla slices.
Sodium azide, a catalase inhibitor, stimulated the generation of medullary prostaglandin E2, while the glutathione peroxidase activator sodium selenite inhibited it. These results suggest that hydroperoxides play an important role in the control of prostaglandin synthesis.
Fujimoto
Y
Y
Yamamoto
T
T
Niwase
N
N
Fujita
T
T
D000818:Animals; D001386:Azides / Q000494:pharmacology*; D066298:In Vitro Techniques; D007679:Kidney Medulla / Q000378:metabolism*; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis*; D011817:Rabbits; D020887:Selenious Acid; D012643:Selenium / Q000494:pharmacology*; D019810:Sodium Azide
D001386:Azides; D011453:Prostaglandins; D019810:Sodium Azide; D020887:Selenious Acid; D012643:Selenium