title: Strategic approaches to drug design. II. Modelling studies on phosphodiesterase substrates and inhibitors.
abstract: Modelling studies have been carried out on the phosphodiesterase (PDE) substrates, adenosine- and guanosine-3'5'-cyclic monophosphates, and on a number of non-specific and type III-specific phosphodiesterase inhibitors. These studies have assisted the understanding of PDE substrate differentiation and the design of potent, selective PDE type III inhibitors.
authors.affiliation: Smith Kline & French Research, The Frythe, Herts, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Davis
authors.forename: B H
authors.initials: BH
authors.lastname: Warrington
authors.forename: J G
authors.initials: JG
authors.lastname: Vinter
mesh_terms: D003196:Computer Graphics; D003198:Computer Simulation; D000242:Cyclic AMP; D006152:Cyclic GMP; D015195:Drug Design; D008968:Molecular Conformation; D010726:Phosphodiesterase Inhibitors; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D013816:Thermodynamics
chemical_list: D010726:Phosphodiesterase Inhibitors; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D006152:Cyclic GMP