Intracellular Ca2+-calmodulin system involved in the palytoxin-induced K+ release from rabbit erythrocytes.
Palytoxin (PTX) caused K+ release from rabbit erythrocytes which was dependent on the concentrations of extracellular Ca2+ and PTX. In a Ca2+-free solution, PTX still caused a slow K+ release. An intracellular Ca2+ antagonist, TMB-8, an intracellular Ca2+ chelator, quin 2, and calmodulin inhibitors, prenylamine, W-7 and W-5, inhibited the PTX-induced K+ release in a Ca2+-free solution. These results suggest that the PTX-induced K+ release is dependent on the process including intracellular Ca2+ and calmodulin.
Nagase
H
H
Ozaki
H
H
Karaki
H
H
Urakawa
N
N
D000178:Acrylamides; D000634:Aminoquinolines / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000097:blood*; D002147:Calmodulin / Q000037:antagonists & inhibitors / Q000097:blood*; D002463:Cell Membrane Permeability / Q000187:drug effects; D003064:Cnidarian Venoms / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D011188:Potassium / Q000097:blood; D011299:Prenylamine / Q000494:pharmacology; D011817:Rabbits; D013449:Sulfonamides / Q000494:pharmacology; D000095702:Polyether Toxins
D000178:Acrylamides; D000634:Aminoquinolines; D002118:Calcium; D002147:Calmodulin; D003064:Cnidarian Venoms; D005707:Gallic Acid; D011188:Potassium; D011299:Prenylamine; D013449:Sulfonamides; C006014:8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate; C017967:W 7; C034700:N-(6-aminohexyl)-1-naphthalenesulfonamide; C035738:Quin2-acetoxymethyl ester; C010272:palytoxin; D000095702:Polyether Toxins