title: Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy.
abstract: The relation between haemoglobin (Hb) concentrations at antenatal booking and subsequent outcome was examined in 54 382 singleton pregnancies. Both high (greater than 13.2 g/dl) and low (less than 10.4 g/dl) Hb values were associated with an adverse outcome. Mothers with a booking Hb in the intermediate range (10.4-13.2 g/dl) fared best. Significant differences emerged in perinatal mortality between those with high and those with intermediate Hb levels at 13-19 weeks' gestation. The frequencies of perinatal death, low birthweight, and preterm delivery were greater with high than with intermediate Hb. There was a striking relation between booking Hb values and the subsequent frequency of hypertension (p less than 0.001). In primiparas, the frequency of subsequent hypertension ranged from 7% at Hb values under 10.5 g/dl to 42% at Hb concentrations over 14.5 g/dl.
authors.forename: J F
authors.initials: JF
authors.lastname: Murphy
authors.forename: J
authors.initials: J
authors.lastname: O'Riordan
authors.forename: R G
authors.initials: RG
authors.lastname: Newcombe
authors.forename: E C
authors.initials: EC
authors.lastname: Coles
authors.forename: J F
authors.initials: JF
authors.lastname: Pearson
mesh_terms: D000328:Adult; D005260:Female; D006306:Health Surveys; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D007226:Infant Mortality; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D010298:Parity; D010953:Plasma Volume; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011295:Prenatal Care; D011336:Probability; D012923:Social Class; D014852:Wales
chemical_list: D006454:Hemoglobins