Use of lipid microspheres as a drug carrier for antitumour drugs.
9-Oxo-15-hydroxy-delta 7,10,13-prostatrienoic acid methyl ester (delta 7-PGA1), an antitumour drug was incorporated into lipid microspheres of 0.2 micron diameter (lipo-delta 7-PGA1). In in-vivo experiments, lipo-delta 7-PGA1 had a significantly greater antitumour activity than free delta 7-PGA1 against P388 leukaemia. Lipo-delta 7-PGA1 slightly, but significantly, prolonged the survival time of mice inoculated with L1210 leukaemia, whereas free delta 7-PGA1 did not. Against MM46 ascites tumour, the survival time after treatment with 10 mg kg-1 of lipo-delta 7-PGA1 was significantly greater than that after the same dose of free delta 7-PGA1. The results suggest that lipid microspheres can be used as drug delivery carriers for lipid soluble antitumour agents.
Mizushima
Y
Y
Shoji
Y
Y
Kato
T
T
Fukushima
M
M
Kurozumi
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002460:Cell Line; D004339:Drug Compounding / Q000379:methods; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D008055:Lipids; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008863:Microspheres; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011455:Prostaglandins A, Synthetic / Q000008:administration & dosage* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D008055:Lipids; D011455:Prostaglandins A, Synthetic; C048481:9-oxo-15-hydroxy-delta 7,10,13-prostatrienoic acid methyl ester