title: Taurine modulates glycine response in Xenopus oocytes injected with messenger RNA from mouse brain.
abstract: The modulatory action of taurine on the glycine response was investigated in Xenopus oocytes injected with messenger RNA from mouse brainstem under voltage-clamped condition. Taurine competitively inhibited the glycine response in a dose-dependent manner. This inhibition was insensitive to bicuculline and intracellularly injected EGTA. The results suggest that taurine could directly modulate glycinergic neurotransmission in the central nervous system.
authors.affiliation: Department of Physiology, School of Dental Medicine, Tsurumi University, Yokohama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Horikoshi
authors.forename: A
authors.initials: A
authors.lastname: Asanuma
authors.forename: K
authors.initials: K
authors.lastname: Yanagisawa
authors.forename: S
authors.initials: S
authors.lastname: Goto
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D018118:Chloride Channels; D002712:Chlorides / Q000378:metabolism / Q000502:physiology; D005260:Female; D005998:Glycine / Q000494:pharmacology; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology; D051379:Mice; D009865:Oocytes / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D018009:Receptors, Glycine; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D013654:Taurine / Q000494:pharmacology*; D014982:Xenopus laevis
chemical_list: D018118:Chloride Channels; D002712:Chlorides; D008565:Membrane Proteins; D012333:RNA, Messenger; D018009:Receptors, Glycine; D017981:Receptors, Neurotransmitter; D013654:Taurine; D005998:Glycine