Isolation and characterization of dipeptidyl peptidase IV from human meconium. Functional role of beta-casomorphins.
Dipeptidyl aminopeptidase IV (DAP-IV) (EC 3.4.14.1) was purified from meconium particles sedimenting at 105 000 X g. Its molecular properties and activity on synthetic and natural substrates (casomorphin and procasomorphin) were investigated.
Caporale
C
C
Fontanella
A
A
Petrilli
P
P
Pucci
P
P
Molinaro
M F
MF
Picone
D
D
Auricchio
S
S
D002364:Caseins / Q000378:metabolism; D018819:Dipeptidyl Peptidase 4; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000302:isolation & purification*; D010450:Endopeptidases / Q000302:isolation & purification*; D004723:Endorphins / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D008470:Meconium / Q000201:enzymology*; D013379:Substrate Specificity
D002364:Caseins; D004723:Endorphins; C021968:beta-casomorphins; D010450:Endopeptidases; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D018819:Dipeptidyl Peptidase 4