Alprazolam-induced manic episode in two patients with panic disorder.
Two patients treated with alprazolam for panic disorder and agoraphobia developed a manic episode. Two biological markers--shortened REM latency and nonsuppression on the dexamethasone suppression test--suggested that both patients may have had an underlying affective disorder.
Pecknold
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Fleury
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D000328:Adult; D000379:Agoraphobia / Q000188:drug therapy; D000525:Alprazolam; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D001008:Anxiety Disorders / Q000188:drug therapy*; D001569:Benzodiazepines / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000139:chemically induced*; D003866:Depressive Disorder / Q000175:diagnosis; D003907:Dexamethasone; D005239:Fear; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010200:Panic; D012895:Sleep, REM
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D003907:Dexamethasone; D006854:Hydrocortisone; D000525:Alprazolam