Expression of vitamin B12 R-binder in breast tumors. An immunohistochemical study.
Vitamin B12 R-binder, a vitamin B12-specific binding protein, was demonstrated by immunohistochemistry in 103 cases of breast tumors of various types and grades. In normal breast tissues, R-binder was found on the luminal surface of interlobular, intralobular, and small terminal ducts. R-binder localization was observed in all fibroadenomas and phyllode tumors, in 90% of the benign epithelial tumors, and in 33% of the carcinomas. Among malignant tumors, 43% of the ductal carcinomas expressed the R-binder, whereas none of the lobular or mucinous carcinomas were positive. In invasive ductal carcinomas, R-binder expression was demonstrated more often in well-differentiated lesions.
Ogawa
K
K
Department of Pathology, Kyoto University, Faculty of Medicine, Japan.
Kudo
H
H
Kim
Y C
YC
Nakashima
Y
Y
Ohshio
G
G
Yamabe
H
H
D001943:Breast Neoplasms / Q000032:analysis* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000032:analysis* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D014155:Transcobalamins / Q000032:analysis*; D014805:Vitamin B 12 / Q000032:analysis*
D014155:Transcobalamins; D014805:Vitamin B 12