Immunophenotyping of acute non-lymphoblastic leukaemias.
Using monoclonal antibodies specific for myelomonocytic cells, 40 non-lymphoblastic leukaemias were analysed applying immunostaining to cytospin preparations. Based on the reactivity patterns six groups of acute non-lymphoblastic leukaemias could be determined, mirroring the bimodal differentiation pathway of myelomonocytic cells. Comparative enzyme cytochemical analysis did not render a clear cut correlation and discrimination of the immunocytochemically defined groups. It is concluded that only the application of a broad panel of immunocytochemical and enzyme cytochemical methods allow a sound subdivision and diagnosis of acute non-lymphoblastic leukaemias.
Bödewadt
S
S
Radzun
H J
HJ
Feller
A C
AC
Parwaresch
M R
MR
D000208:Acute Disease; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D006098:Granulocytes / Q000201:enzymology; D006801:Humans; D007938:Leukemia / Q000097:blood / Q000201:enzymology / Q000473:pathology*; D009000:Monocytes / Q000201:enzymology; D009283:Naphthol AS D Esterase / Q000097:blood; D010544:Peroxidases / Q000097:blood
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D010544:Peroxidases; D009283:Naphthol AS D Esterase; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase