Benzodiazepine inverse agonist FG-7142-induced delayed behavioral depression in mice.
Effect of acute administration of a benzodiazepine-inverse agonist, FG-7142, on forced swimming-induced depression was investigated in mice. A single injection of FG-7142 (40 mg/kg) showed a delayed increase in behavioral despair, the peak effect being observed on the 5th and 6th day of FG-7142 administration. beta-Adrenoceptor agonist isoprenaline significantly potentiated FG-7142-induced behavioral despair. FG-7142-induced depression was sensitive to reversal by chronic treatment with propranolol or desipramine. These observations suggest that the inverse agonist FG-7142 upregulates beta-adrenoceptor population leading to behavioral despair in mice.
Chopra
K
K
Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Kunchandy
J
J
Kulkarni
S K
SK
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002243:Carbolines / Q000494:pharmacology*; D003864:Depression, Chemical; D003891:Desipramine / Q000494:pharmacology; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects*; D013997:Time Factors
D001067:Appetite Depressants; D002243:Carbolines; D011963:Receptors, GABA-A; C035874:FG 7142; D011433:Propranolol; D007545:Isoproterenol; D003891:Desipramine