Genetically determined predisposition to convulsions as the result of a generalized defect in the metabolism of catecholamines in the central nervous system.
The author compared the functional properties of the striatal system in KM rats sensitive to the convulsive effects of sound with those in Wistar rats, which are insensitive to these effects. It was shown that bulbocapnine (an antagonist of dopamine) administered to the Wistar rats at a dose of 40 mg/kg body weight caused catalepsy, depressed the motor cortex excitability, and raised the threshold of the generalized Jacksonian-type convulsions. The KM rats showed neither catalepsy nor a rise in the generalized convulsion threshold, and the depression of the motor cortex excitability in them was only slight. Examinations of the apomorphine-induced stereotypy (dose 1.0-10 mg/kg) showed that in the KM rats the sensitivity of the receptors to dopamine was changed. The hyperproduction of catecholamines in the striatum, the hypothalamus, and adrenals in the KM rats suggests that the predisposition to epileptiform states correlates with the generalized defect in the metabolism of catecholamines. It is suggested that the hypersensitivity of KM rats to epileptogenic effects is due to a deficiency (caused by an excess of dopamine) in the depressing function of the striatum.
Dolina
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D000161:Acoustic Stimulation; D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001060:Aporphines / Q000494:pharmacology; D002395:Catecholamines / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology; D004198:Disease Susceptibility; D007031:Hypothalamus / Q000378:metabolism; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D012640:Seizures / Q000235:genetics* / Q000503:physiopathology; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D001060:Aporphines; D002395:Catecholamines; D014446:Tyrosine 3-Monooxygenase; D001058:Apomorphine