Bleeding symptoms in carriers of hemophilia A and B.
In order to investigate the bleeding tendency in clinically identified carriers of hemophilia, a self-administered questionnaire was held among 135 carriers of hemophilia A and B, 25 females with relatives with hemophilia and a matched group consisting of 60 females without relatives with hemophilia. Carriers of hemophilia appeared to suffer more often from bleeding than their relatives or the matched unrelated control group. A relation was seen between factor VIII:C or IX:C activity and the tendency to bleed. Obligatory carriers with normal factor VIII:C levels showed no bleeding tendency and were in this respect similar to a group of 25 females with relatives with hemophilia. This study shows that it is important to assay factor VIII:C or IX:C also in those women in whom the carrier status has already been established otherwise.
Mauser Bunschoten
E P
EP
Van Creveld Clinic, Bilthoven, The Netherlands.
van Houwelingen
J C
JC
Sjamsoedin Visser
E J
EJ
van Dijken
P J
PJ
Kok
A J
AJ
Sixma
J J
JJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000941:Antigens / Q000032:analysis; D001760:Bleeding Time; D001777:Blood Coagulation; D002648:Child; D005164:Factor IX / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005260:Female; D008040:Genetic Linkage; D006467:Hemophilia A / Q000097:blood* / Q000235:genetics; D002836:Hemophilia B / Q000097:blood* / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008875:Middle Aged; D011795:Surveys and Questionnaires; D014960:X Chromosome
D000941:Antigens; D005169:Factor VIII; D005164:Factor IX