title: Somatostatin and water excretion in man: an intrarenal action.
abstract: Intravenous infusion of somatostatin in six water loaded normal human subjects produced a prompt reduction in urine flow accompanied by a rise in urine osmolality and a decrease in free water clearance. Plasma AVP levels did not change. Somatostatin would seem to exert an antidiuretic effect directly on the kidney.
authors.forename: B J
authors.initials: BJ
authors.lastname: Walker
authors.forename: P A
authors.initials: PA
authors.lastname: Evans
authors.forename: M L
authors.initials: ML
authors.lastname: Forsling
authors.forename: G A
authors.initials: GA
authors.lastname: Nelstrop
mesh_terms: D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008297:Male; D009994:Osmolar Concentration; D013004:Somatostatin / Q000494:pharmacology*; D014554:Urination / Q000187:drug effects; D014867:Water / Q000378:metabolism*
chemical_list: D014867:Water; D001127:Arginine Vasopressin; D013004:Somatostatin