title: [Role of the humoral factor and postsynaptic sensitization in heterosynaptic facilitation].
abstract: It is shown that heterosynaptic facilitation of the synaptic transmission in the giant neurons of the cerebral ganglion in Planorbis corneus develops due to the diffuse neurohumoral effects on the pre- and postsynaptic structures but not as a result of the local synaptic influences on the presynaptic mechanisms. Using the new biological object it has been confirmed that serotonin from the perfuse solution was a source of the facilitatory action on the n-cholinergic synaptic transmission. It was established that conditioning stimulations facilitated not only the n-cholinergic synaptic transmission but also the ionophoretic acetylcholine potentials. Amplitudes of EPSPs and acetylcholinic potentials increased 4-6 times, while the postsynaptic membrane impedance increased only by 20%. Based on such data it is summarized that sensitization of n-cholinergic receptors of the postsynaptic membrane contributed much to the heterosynaptic facilitation. The possible role of n-cholinergic receptors of the postsynapcit membrane in the processes of the heterosynaptic facilitation and of the conditional training is discussed.
authors.forename: V M
authors.initials: VM
authors.lastname: Storozhuk
authors.forename: I N
authors.initials: IN
authors.lastname: Antonov
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002799:Cholinergic Fibers / Q000187:drug effects; D005724:Ganglia / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D008974:Mollusca; D018377:Neurotransmitter Agents / Q000502:physiology*; D011978:Receptors, Nicotinic / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D018377:Neurotransmitter Agents; D011978:Receptors, Nicotinic; D012701:Serotonin; D008238:Lysergic Acid Diethylamide; D000109:Acetylcholine
vernacular_title: Rol' gumoral'nogo faktora i postsinapticheskoĭ sensitizatsii v geterosinapticheskom oblegchenii.