Intracisternal glycine activates the micturition reflex in urethane-anaesthetized rats.
Intracisternal glycine, but not GABA, activates a series of neurogenic rhythmic contractions of the urinary bladder in urethane-anaesthetized rats. This effect of glycine was prevented by strychnine but not by bicuculline, indicating the involvement of specific glycinergic receptors. The effects of glycine were also prevented by either atropine or haloperidol suggesting an involvement of cholinergic and monoaminergic excitatory neurotransmission to the bladder.
Maggi
C A
CA
Furio
M
M
Santicioli
P
P
Meli
A
A
D000758:Anesthesia; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D002946:Cisterna Magna; D005998:Glycine / Q000008:administration & dosage / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D007267:Injections; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000187:drug effects; D013331:Strychnine / Q000494:pharmacology; D014520:Urethane; D014554:Urination / Q000187:drug effects*
D014520:Urethane; D001285:Atropine; D013331:Strychnine; D006220:Haloperidol; D005998:Glycine; D001640:Bicuculline