[Mechanism of the radioprotective effect of catecholamine receptor agonists. Inclusion in the radioprotective effect of different subtypes of beta-adrenoreceptors].
Isoproterenol of ED50 = 0.16 mumol/kg is highly effective in protecting mice against ionizing radiation and has the high therapeutical index. There are three new indications that isoproterenol exerts its radioprotective action via beta-adrenoceptors. They are: the effect of isoproterenol is prevented by three additional beta-adrenoceptor antagonists, the isoproterenol effect is reproduced by the seven studied beta-adrenoceptor agonists of different chemical structure, and with chemical analogs which fail to stimulate beta-adrenoceptors the radioprotective effect is absent. Both beta 1 and beta 2 adrenoceptor agonists are protective agents. Mechanisms of the radioprotective action are discussed.
Kulinskiĭ
V I
VI
Klimova
A D
AD
Iashunskiĭ
V G
VG
Alpatova
T V
TV
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D000318:Adrenergic beta-Agonists; D011837:Radiation-Protective Agents; D007545:Isoproterenol
Issledovanie mekhanizma radiozashchitnogo éffekta agonistov katekholaminovykh retseptorov. Vkliuchenie v radiozashchitnyĭ éffekt raznykh podtipov beta-adrenoretseptorov.