The strategy and value of neuroleptic drug monitoring.
The concept of monitoring neuroleptic drugs by means of chemical or pharmacological assays is considered from a historical and strategic point of view. The objectives of compliance control, reduction of long-term exposure, titration to a therapeutic range, and solution of medicolegal problems are separately considered. The relative merits of chemically specific (mainly chromatographic) and clinically specific (radioreceptor) assays are considered. An algorithm for interpretation of a neuroleptic concentration measurement is presented.
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D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000032:analysis* / Q000627:therapeutic use; D002746:Chlorpromazine / Q000097:blood; D002849:Chromatography, Gas; D002853:Chromatography, Liquid; D005476:Fluphenazine / Q000097:blood; D005554:Forensic Medicine; D006220:Haloperidol / Q000032:analysis; D006801:Humans; D010349:Patient Compliance; D010546:Perphenazine / Q000097:blood; D010640:Phenothiazines / Q000097:blood; D011869:Radioligand Assay; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D013881:Thioridazine / Q000097:blood; D013888:Thiothixene / Q000097:blood; D014268:Trifluoperazine / Q000097:blood
D014150:Antipsychotic Agents; D010640:Phenothiazines; D014268:Trifluoperazine; D013888:Thiothixene; D010546:Perphenazine; D006220:Haloperidol; D013881:Thioridazine; D005476:Fluphenazine; D002746:Chlorpromazine