The effects of vasoconstricting prostanoids on the coronary and hindlimb vascular beds of the conscious sheep.
Vasoconstricting prostaglandins were injected, in bolus doses, into the lower abdominal aorta on the left circumflex coronary artery (LCCA) of conscious sheep. Local blood flow, mean arterial pressure (MAP), heart rate (HR) and ECG were continuously monitored. Thromboxane B2 had no effect on either vascular bed in doses up to 100 micrograms. PGF2 alpha produced mild vasoconstriction in both vascular beds with no systemic response. The endoperoxide analogues, U-44069 and U-46619, produced complex responses in both vascular beds. Initial vasodilation was followed rapidly by prolonged vasoconstriction. In the coronary circulation, vasoconstriction was temporarily masked by a hyperaemic phase. The U-compounds also affected MAP, possibly as a result of pulmonary and systemic vasoconstriction.
Carter
J
J
Reynoldson
J A
JA
Thorburn
G D
GD
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D015237:Dinoprost; D005260:Female; D006614:Hindlimb / Q000098:blood supply*; D008297:Male; D011449:Prostaglandin Endoperoxides / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D012756:Sheep; D013929:Thromboxane B2 / Q000494:pharmacology; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D011449:Prostaglandin Endoperoxides; D011453:Prostaglandins; D011460:Prostaglandins F; D014662:Vasoconstrictor Agents; D013929:Thromboxane B2; D015237:Dinoprost