Lymphatic transport of sodium cefoxitin in the presence of sodium 5-methoxysalicylate after injection into rat rectal connective tissue, femoral muscle and femoral vein.
Lymphatic uptake of sodium cefoxitin after injection into rectal connective tissue was greater than after injection into the femoral muscle of rats. Coadministration with sodium 5-methoxysalicylate enhanced lymphatic drug uptake at both sites. This enhancement may be an indirect result of 5-methoxysalicylate's suppression of vascular permeation of the cefoxitin. An adjuvant-induced increase in lymphatic fluid flow may also be partially involved in the enhancement of cefoxitin lymphatic transport.
Nishihata
T
T
Kim
S
S
Kamada
A
A
Frederick
G
G
Dillsaver
M
M
Higuchi
T
T
D000818:Animals; D001693:Biological Transport, Active; D002440:Cefoxitin / Q000097:blood / Q000378:metabolism*; D003238:Connective Tissue / Q000378:metabolism*; D062425:Hydroxybenzoate Ethers; D008208:Lymphatic System / Q000378:metabolism*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012007:Rectum / Q000378:metabolism; D012459:Salicylates / Q000494:pharmacology*; D013997:Time Factors
D062425:Hydroxybenzoate Ethers; D012459:Salicylates; C033304:5-methoxysalicylic acid; D002440:Cefoxitin