On the clinical relevance and methods of quantification of plasma concentrations of neuroleptics.
Literature concerning quantification of plasma concentrations of neuroleptics is reviewed with a particular emphasis on the radioreceptor assay. Based on previously published reports and their own data, the authors conclude that further studies on factors influencing the results of the radioreceptor assay are needed prior to its application in the clinic. Furthermore, the original suggestion of using a single standard reference drug for all neuroleptics may be misleading. Rather, known concentrations of each neuroleptic quantified need to be used as standards.
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D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism; D001665:Binding Sites; D002849:Chromatography, Gas; D003342:Corpus Striatum / Q000378:metabolism; D005006:Ethnicity; D005500:Follow-Up Studies; D006220:Haloperidol / Q000097:blood; D006801:Humans; D007700:Kinetics; D009961:Orosomucoid / Q000097:blood; D011388:Prolactin / Q000097:blood; D011869:Radioligand Assay; D051381:Rats; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D013134:Spiperone / Q000378:metabolism; D013881:Thioridazine / Q000097:blood
D014150:Antipsychotic Agents; D009961:Orosomucoid; D013134:Spiperone; D011388:Prolactin; D006220:Haloperidol; D013881:Thioridazine