Modulation of postjunctional alpha-adrenergic responsiveness by local changes in temperature.
In canine cutaneous veins, local moderate warming (37 degrees-41 degrees C) augments the responsiveness to postjunctional alpha 1-adrenergic stimulation but depresses that to postjunctional alpha 2-adrenergic activation. Moderate cooling (37 degrees-24 degrees C) has the opposite effect. The effects of warming and cooling on alpha 1-adrenergic responses are buffered by a large receptor reserve, allowing for the predominance of alterations in alpha 2-adrenergic responsiveness.
Vanhoutte
P M
PM
Cooke
J P
JP
Lindblad
L E
LE
Shepherd
J T
JT
Flavahan
N A
NA
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D012501:Saphenous Vein; D009435:Synaptic Transmission / Q000187:drug effects; D013696:Temperature
D000316:Adrenergic alpha-Agonists; D011942:Receptors, Adrenergic, alpha; D011188:Potassium; D009638:Norepinephrine