Biochemical studies on endosulfan toxicity in different age groups of rats.
The effect of oral administration of endosulfan (12.5 mg/kg body weight), daily, for 4 days was investigated in female rats of 4 different age groups, i.e., 15, 30, 70, and 365 days old. Maximum hyperglycemia, maximum depletion of liver glycogen and maximum inhibition of brain acetylcholine esterase activity were observed in 365-day-old (adult) animals whereas these changes were found to be negligible in 15-day-old animals. A decrease in the activity of liver aldolase was observed in rats of all age groups but maximum decrease was observed in adult rats. In contrast to these changes, erythrocyte (Na+, K+)-ATPase was maximally inhibited in 15-day-old rats. These studies indicated that the toxic effects of endosulfan are age-dependent.
Kiran
R
R
Department of Biochemistry, Panjab University, Chandigarh, India.
Varma
M N
MN
D000110:Acetylcholinesterase / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001921:Brain / Q000201:enzymology; D050260:Carbohydrate Metabolism; D004726:Endosulfan / Q000008:administration & dosage / Q000633:toxicity*; D004910:Erythrocyte Membrane / Q000201:enzymology; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008112:Liver Glycogen / Q000032:analysis; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D001786:Blood Glucose; D008112:Liver Glycogen; D000110:Acetylcholinesterase; D005634:Fructose-Bisphosphate Aldolase; D000254:Sodium-Potassium-Exchanging ATPase; D004726:Endosulfan