title: Evidence for an adrenal contribution to plasma digitalis-like factors.
abstract: Digitalis-like factors (DLF) were assayed on plasma collected serially using antibody to digoxin: (1) after intravenous ACTH (n = 3 patients) and (2) after 0.15 U/kg crystalline insulin, 50 micrograms gonadotropin-releasing hormone and 0.2 mg thyrotropin-releasing hormone (n = 7) as a combined pituitary function test. Patients had either hypothalamic-pituitary or ovarian problems. Mean values for DLF rose fourfold after ACTH, and by a factor of 2.3 with the combined pituitary function test. DLF rose at least 50% in all 10 subjects. In 3 dogs, adrenal vein values for DLF were on average more than double values in either adrenal artery or lower vena cava. These results suggest that certain DLFs have an adrenal origin.
authors.affiliation: Department of Medicine, General Hospital, St. John's, Nfld., Canada.
authors.forename: M H
authors.initials: MH
authors.lastname: Gault
authors.forename: S
authors.initials: S
authors.lastname: Vasdev
authors.forename: L
authors.initials: L
authors.lastname: Longerich
authors.forename: E
authors.initials: E
authors.lastname: Johnson
authors.forename: N
authors.initials: N
authors.lastname: Farid
authors.forename: Y
authors.initials: Y
authors.lastname: Legal
authors.forename: V
authors.initials: V
authors.lastname: Prabhakaran
authors.forename: A
authors.initials: A
authors.lastname: Fine
mesh_terms: D000311:Adrenal Glands / Q000502:physiology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000328:Adult; D000818:Animals; D001798:Blood Proteins / Q000097:blood*; D002298:Cardenolides; D004077:Digoxin / Q000276:immunology; D004285:Dogs; D005260:Female; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D012503:Saponins; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
chemical_list: D001798:Blood Proteins; D002298:Cardenolides; D007328:Insulin; D012503:Saponins; C034504:digoxin-like factors; D013973:Thyrotropin-Releasing Hormone; D004077:Digoxin; D000324:Adrenocorticotropic Hormone