title: Sclerosing stromal tumor of the ovary. A light, electron microscopic and enzyme histochemical study.
abstract: A sclerosing stromal ovarian tumor from a 15-year-old girl was studied. Enzyme histochemistry demonstrated the presence of 17 beta-estradiol, secondary alcohol, glucose-6-phosphate, and isocitrate dehydrogenase activities, strongly implicating that the tumor had steroidogenic capability. Electron microscopy revealed a diverse cellular population composed of conspicuous lipid-laden cells, fibroblast-like and undifferentiated primitive mesenchymal cells. The findings of the latter cell type and intermediate forms confirmed the stromal origin of sclerosing stromal tumor of the ovary.
authors.affiliation: Department of Pathology, Northwest Community Hospital, Arlington Heights, IL 60005.
authors.forename: R M
authors.initials: RM
authors.lastname: Lam
authors.forename: P
authors.initials: P
authors.lastname: Geittmann
mesh_terms: D015067:17-Hydroxysteroid Dehydrogenases / Q000032:analysis; D000293:Adolescent; D000426:Alcohol Dehydrogenase / Q000032:analysis; D005260:Female; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000032:analysis; D008854:Microscopy, Electron; D010051:Ovarian Neoplasms / Q000201:enzymology / Q000648:ultrastructure; D012598:Sclerosis
chemical_list: D005958:Glucosephosphates; D019298:Glucose-6-Phosphate; D015067:17-Hydroxysteroid Dehydrogenases; D000426:Alcohol Dehydrogenase; C032690:3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)); D007521:Isocitrate Dehydrogenase; C044256:3 (or 17)-beta-hydroxysteroid dehydrogenase