title: Electroconvulsive shock and reserpine increase alpha 1-adrenoceptor binding sites but not norepinephrine-stimulated phosphoinositide hydrolysis in rat brain.
abstract: Repeated treatment of rats with either electroconvulsive shock or reserpine increased the density of alpha 1-adrenoceptor binding sites labeled by [3H]prazosin in rat frontal cerebral cortex. In contrast, norepinephrine-stimulated phosphoinositide hydrolysis, which is mediated by alpha 1-adrenoceptors, was not significantly affected by either treatment. These data suggest that electroconvulsive shock and reserpine might increase only or predominantly a subtype of alpha 1-adrenoceptor that is not coupled to phosphoinositide hydrolysis.
authors.affiliation: Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20007.
authors.forename: J A
authors.initials: JA
authors.lastname: Blendy
authors.forename: C A
authors.initials: CA
authors.lastname: Stockmeier
authors.forename: K J
authors.initials: KJ
authors.lastname: Kellar
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D004597:Electroshock; D006868:Hydrolysis; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000378:metabolism*; D011224:Prazosin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D012110:Reserpine / Q000494:pharmacology*
chemical_list: D010716:Phosphatidylinositols; D011942:Receptors, Adrenergic, alpha; D012110:Reserpine; D009638:Norepinephrine; D011224:Prazosin