title: Post-operative chemotherapy for ovarian carcinoma: a prospective study with cyclophosphamide.
abstract: Seventy consecutive patients with carcinoma of the ovary were managed in our unit by laparotomy and extensive debulking procedures over a period of 8 years. Intensive post-operative chemotherapy was given with intravenous cyclophosphamide. The mean follow-up period was 2.6 years. Our results showed that 19 patients with early disease (stages I and II) showed complete remission but seven subsequently died of recurrent disease. The others with more advanced disease showed little response to treatment.
authors.forename: A
authors.initials: A
authors.lastname: Akinkugbe
authors.forename: V E
authors.initials: VE
authors.lastname: Uguru
authors.forename: V P
authors.initials: VP
authors.lastname: Mordi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D011182:Postoperative Care; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D003520:Cyclophosphamide