Serotonin regulation of aldosterone secretion.
The circulating levels of aldosterone (A), cortisol (F), prolactin, ACTH and potassium and the PRA were studied in 8 (6 males and 2 females) healthy normotensive subjects after 5-hydroxy-tryptophan (5OHT), or pizotifen (Piz) or placebo oral administration. In the same subjects 5OHT was administered twice: after placebo and after dexamethasone pretreatment. The results showed a significant increase of A, ACTH and F after 5OHT plus placebo administration without any change of PRA, potassium or prolactin levels; dexamethasone pretreatment suppressed ACTH and F but was uneffective on the response of A to 5OHT. Only A levels showed a significant decrease after Piz administration, the other studied parameters were unaffected by the blockade of the 5HT2 receptors by Piz. The administration of placebo induced a slight but not significant decrease of the studied parameters. Our results suggest the existence of a physiologic serotonergic control of A secretion, a pituitary factor could be one of the putative links between the central serotonergic activation and the adrenal secretory response.
Maestri
E
E
University of Parma, Italy.
Camellini
L
L
Rossi
G
G
Rossi
G P
GP
Dotti
C
C
Marchesi
M
M
Gnudi
A
A
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010918:Pizotyline / Q000494:pharmacology*; D011188:Potassium / Q000097:blood; D011388:Prolactin / Q000097:blood; D012083:Renin / Q000097:blood; D012701:Serotonin / Q000502:physiology*; D013876:Thiophenes / Q000494:pharmacology*
D013876:Thiophenes; D010918:Pizotyline; D012701:Serotonin; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D006916:5-Hydroxytryptophan; D012083:Renin; D011188:Potassium; D006854:Hydrocortisone