title: Alpha- and beta-adrenergic receptor blockers and the effects of noradrenaline on heat production and body temperature.
abstract: Noradrenaline (NA) administered systemically or into the lateral cerebral ventricle (ICV) in appropriate doses increased heat production and colonic temperature in 1-12 day-old guinea pigs. The effect of systemically applied NA could be blocked by systemically applied beta-adrenergic receptor blockers, while beta-blockers administered centrally or alpha-adrenergic blockers injected systemically or centrally had no effect on the action of systemically applied NA. Accordingly, the effect of systemically applied NA was mediated by peripheral beta-adrenergic receptors. The effect of centrally applied NA was blocked by alpha-adrenergic receptor antagonists applied into the lateral cerebral ventricle and attenuated by systemically applied phentolamine, but not by phenoxybenzamine or ergotamine. Beta-adrenergic receptor blocking agents applied either ICV or systemically had no effect on the action of centrally applied NA. It is concluded that ICV applied NA acts through central alpha-adrenergic receptors.
authors.forename: I
authors.initials: I
authors.lastname: Komáromi
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001833:Body Temperature Regulation / Q000187:drug effects*; D004878:Ergotamine / Q000494:pharmacology; D006168:Guinea Pigs; D007276:Injections, Intraventricular; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D010643:Phenoxybenzamine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology
chemical_list: D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D010643:Phenoxybenzamine; D011433:Propranolol; D004878:Ergotamine; D011217:Practolol; D009638:Norepinephrine; D010646:Phentolamine