title: Codon usage in Pseudomonas aeruginosa.
abstract: We have generated a codon usage table for Pseudomonas aeruginosa. Codon usage in P. aeruginosa is extremely biased. In contrast to E. coli and yeast, P. aeruginosa preferentially uses those codons within a synonymous codon group with the strongest predicted codon-anticodon interaction. We were unable to correlate a particular codon usage pattern with predicted levels of mRNA expressivity. The choice of a third base reflects the high guanine plus cytosine content of the P. aeruginosa genome (67.2%) and cytosine is the preferred nucleotide for the third codon position.
authors.affiliation: Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, NY 14642.
authors.forename: S E
authors.initials: SE
authors.lastname: West
authors.forename: B H
authors.initials: BH
authors.lastname: Iglewski
mesh_terms: D001435:Bacteriophages / Q000235:genetics; D002876:Chromosomes, Bacterial; D003062:Codon; D004251:DNA Transposable Elements; D005786:Gene Expression Regulation; D005796:Genes; D005798:Genes, Bacterial; D010957:Plasmids; D011550:Pseudomonas aeruginosa / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D003062:Codon; D004251:DNA Transposable Elements; D012333:RNA, Messenger