Alterations of accumbens neuronal activity in freely moving rats following methamphetamine.
Multiple unit activity in the nucleus accumbens, locomotor activity, and stereotyped behavior were simultaneously recorded in freely moving rats. An intraperitoneal injection of 1.5 mg/kg methamphetamine produced an increase in the firing rate while a decrease in the discharge rate occurred following an administration of 4.5 mg/kg methamphetamine. In addition, the unit activity was positively correlated with the locomotor activity and negatively correlated with the stereotypy score. These results suggest that accumbens neuronal activation during locomotor hyperactivity may partly depend on the feedback from locomotion.
Fukuzako
H
H
Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Japan.
Nagatomo
I
I
Nomaguchi
M
M
Takenouchi
K
K
Matsumoto
K
K
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D009714:Nucleus Accumbens / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D008694:Methamphetamine