Cyclic nucleotides and gap-junctional permeability.
1. The role of cAMP on cell-to-cell diffusion of Lucifer Yellow was investigated. It was found that dB-cAMP or isoproterenol increases the junctional permeability appreciably in dog's atrium muscle. 2. This effect which occurs within 85 min seems to be related to an increase in unit channel permeability. Chronic treatment of animals with ephedrine enhances the junctional permeability in vivo. 3. The results support the view that cAMP plays a short-term and long-term regulatory role on junctional permeability.
De Mello
W C
WC
Department of Pharmacology, Medical Sciences Campus, San Juan, Puerto Rico 00936.
D000818:Animals; D002450:Cell Communication; D002463:Cell Membrane Permeability / Q000187:drug effects*; D000242:Cyclic AMP / Q000494:pharmacology / Q000502:physiology*; D004285:Dogs; D007365:Intercellular Junctions / Q000187:drug effects / Q000502:physiology*; D007545:Isoproterenol / Q000494:pharmacology; D007546:Isoquinolines
D007546:Isoquinolines; C017475:lucifer yellow; D000242:Cyclic AMP; D007545:Isoproterenol