Disturbed adrenergic regulation of coronary flow in the guinea-pig heart after endotoxin.
We investigated the functional responsiveness of alpha- and beta-adrenoceptors in the isolated guinea-pig heart and coronary vascular system, 4 days after pretreatment with endotoxin. It was found that endotoxin reduced the flow-increasing effect of salbutamol and enhanced the flow-decreasing effect of B-HT 920. The positive chronotropic and inotropic effects of dobutamine and salbutamol and the flow-decreasing effect of phenylephrine were not influenced by endotoxin pretreatment. It is concluded that bacterial endotoxin induces alpha 2-adrenoceptor hyperreactivity and beta 2-adrenoceptor impairment in the coronary vascular system of the guinea-pig heart.
Van Heuven-Nolsen
D
D
De Wildt
D J
DJ
Nijkamp
F P
FP
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects*; D004280:Dobutamine / Q000494:pharmacology; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011941:Receptors, Adrenergic / Q000187:drug effects*; D010566:Virulence Factors, Bordetella / Q000494:pharmacology*
D000316:Adrenergic alpha-Agonists; D001381:Azepines; D011941:Receptors, Adrenergic; D010566:Virulence Factors, Bordetella; D004280:Dobutamine; C024763:talipexole; D000420:Albuterol