Synthesis of 24-heteroatom-substituted cholestanols.
Short syntheses of 24-thia-5 alpha,20 xi-cholestan-3 beta-ol, 24-methyl-24-aza-5 alpha,20 xi-cholestan-3 beta-ol, and 24-nor-5 alpha,20 xi-cholan-3 beta-ol from 3 beta-hydroxy-5 alpha-pregnan-20-one are described. The products and synthetic intermediates have been fully characterized by the results of proton NMR, infrared, and high and low resolution mass spectral studies.
Rahman
M D
MD
Department of Chemistry, Princeton University, NJ 08544.
Seidel
H M
HM
Pascal
R A
RA
D002777:Cholestanols / Q000032:analysis / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D011522:Protons
D002777:Cholestanols; D011522:Protons