[Natural peptides and their analogs. XXXV. Synthesis and properties of [Ala5, Orn9]somatostatin].
A total chemical synthesis of [Ala5, Orn9]somatostatin has been performed. This structural analogue of natural somatostatin inhibits the release of somatotropin, insulin and glucagon, but shows no inhibitory effect on secretion of prolactin.
Shvachkin
Iu P
IuP
Smirnova
A P
AP
Ermak
N M
NM
Fedotov
V P
VP
Sadovnikova
N V
NV
D000818:Animals; D002478:Cells, Cultured; D002855:Chromatography, Thin Layer; D002942:Circular Dichroism; D005934:Glucagon / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
D007328:Insulin; C049106:somatostatin, Ala(5)-Orn(9)-; D013004:Somatostatin; D011388:Prolactin; D013006:Growth Hormone; D005934:Glucagon
Prirodnye peptidy i ikh analogi. XXXV. Sintez i svoĭstva [Ala5, Orn9]somatostatina.