The effect of some hepatotoxins on the sulphoxidation of cimetidine in rat.
Sulphoxidation of cimetidine was investigated in male and female rats after pretreatment with the hepatotoxins allyl alcohol, dl-ethionine, thioacetamide and carbon tetrachloride. There was a marked sex difference in cimetidine sulphoxidation in response to the hepatotoxin pretreatment. All the hepatotoxins enhanced cimetidine sulphoxidation in the male rat (P less than 0.01). Carbon tetrachloride and thioacetamide inhibited cimetidine sulphoxidation in the female rat (P less than 0.01) but dl-ethionine and allyl alcohol had no effect on this metabolic pathway.
Dixon
P A
PA
Udeagha
A U
AU
D000433:1-Propanol / Q000506:poisoning; D000818:Animals; D001969:Bromobenzenes / Q000506:poisoning; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D002927:Cimetidine / Q000378:metabolism*; D020005:Propanols; D051381:Rats; D011919:Rats, Inbred Strains; D013454:Sulfoxides / Q000378:metabolism*; D013853:Thioacetamide / Q000506:poisoning
D001969:Bromobenzenes; D020005:Propanols; D013454:Sulfoxides; D013853:Thioacetamide; C006463:allyl alcohol; D002927:Cimetidine; D000433:1-Propanol; C032036:bromobenzene