The mechanism of ischemia-induced brain cell injury. The membrane theory.
Temporal ischemia of the brain injures only the selectively vulnerable brain cells. The dying process evolves along with glutamate-mediated intracellular signal-transduction system, together with a loss of Ca2+ homeostasis. Such post-ischemic changes eventually disrupt functional and structural integrity of the cell membrane and kill the neuron. Molecular basis in pharmacoprotective agents is discussed.
Kogure
K
K
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Tanaka
J
J
Araki
T
T
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000166:cytology* / Q000473:pathology / Q000648:ultrastructure; D001930:Brain Injuries / Q000503:physiopathology*; D002545:Brain Ischemia / Q000503:physiopathology*; D002121:Calcium Channel Blockers / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D002470:Cell Survival; D005849:Gerbillinae; D008854:Microscopy, Electron; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000502:physiology; D012964:Sodium / Q000502:physiology
D002121:Calcium Channel Blockers; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D012964:Sodium