Induction of hippocampal long-term potentiation in the absence of extracellular Ca2+.
Extracellular Ca2+, synaptic transmission, and the activation of subsynaptic receptors are not required for the induction of long-term potentiation of excitatory synaptic transmission at stratum radiatum-CA1 neuron junctions as long as sufficient depolarizations of the presynaptic terminals and the postsynaptic neurons co-occur.
May
P B
PB
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Goh
J W
JW
Sastry
B R
BR
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010852:Picrotoxin / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects*
D002118:Calcium; D010852:Picrotoxin; D011188:Potassium