title: [Elevated Na+/H+ exchange in erythrocytes of patients with hypertension].
abstract: The kinetics of proton efflux from erythrocytes with acidified cytoplasm (pHi 6.4) in a medium with pH 8.0 has been studied. The participation of the anion exchanger in this process was blocked by a stilbene disulfonic acid derivative. It was shown that the rate of Na+/H+ exchange (amiloride-inhibited component of proton efflux) is increased 2 fold. The addition of protein kinase C activator (1 microM of TPA) results in the increase of the rate of Na+/H+ exchange by 4 fold.
authors.forename: S N
authors.initials: SN
authors.lastname: Orlov
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Postnov
authors.forename: N I
authors.initials: NI
authors.lastname: Pokudin
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Kukharenko
authors.lastname: Postnov Iuv
mesh_terms: D000328:Adult; D002352:Carrier Proteins / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011493:Protein Kinase C / Q000097:blood; D011522:Protons; D012964:Sodium / Q000097:blood*; D017923:Sodium-Hydrogen Exchangers
chemical_list: D002352:Carrier Proteins; D011522:Protons; D017923:Sodium-Hydrogen Exchangers; D012964:Sodium; D011493:Protein Kinase C
vernacular_title: Uvelichennyĭ Na+/H+-obmen v éritrotsitakh bol'nykh gipertonicheskoĭ bolezn'iu.