[Effect of alpha-tocopherol on glutamic acid metabolism and nicotinamide coenzyme levels in hepatocytes].
Activity of enzymes participating in metabolism of glutamate and content of nicotinamide nucleotides was studied in rat liver tissue within 24 hrs after intramuscular administration of alpha-tocopheryl acetate at doses of 30 mg and 300 mg per kg of body mass. Excess of the vitamin was responsible for a decrease in the ratio NAD+/NADH in cytosol, for stimulation of glutamate dehydrogenase reaction, for a decrease of aspartate aminotransferase activity in mitochondria and of alanine aminotransferase activity in cytosol as well as for an increase of NADPH content.
Iakhnina
D N
DN
Agabekova
I I
II
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D003067:Coenzymes / Q000378:metabolism*; D003641:Deamination; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D009536:Niacinamide / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology*
D003067:Coenzymes; D005971:Glutamates; D014810:Vitamin E; D009536:Niacinamide; D018698:Glutamic Acid; D005969:Glutamate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Vliianie alpha-tokoferola na obmen glutaminovoĭ kisloty i soderzhanie nikotinamidnykh fermentov v gepatotsitakh.