title: Recombinant human interferon alfa-A suppresses HTLV-III replication in vitro.
abstract: Recombinant human interferon alfa-A (rIFN alpha A) had a dose-related suppressive effect on human T lymphotropic virus type III (HTLV-III) replication in vitro in normal peripheral-blood mononuclear cells (PBMC). Both single-dose and multiple-dose regimens were inhibitory. Such inhibitory concentrations (4-1024 units/ml) were not toxic to PBMC in culture, and were within the ranges achievable in blood after injection. These studies suggest that clinical trials of rIFN alpha A in early HTLV-III infection are warranted.
authors.forename: D D
authors.initials: DD
authors.lastname: Ho
authors.forename: K L
authors.initials: KL
authors.lastname: Hartshorn
authors.forename: T R
authors.initials: TR
authors.lastname: Rota
authors.forename: C A
authors.initials: CA
authors.lastname: Andrews
authors.forename: J C
authors.initials: JC
authors.lastname: Kaplan
authors.forename: R T
authors.initials: RT
authors.lastname: Schooley
authors.forename: M S
authors.initials: MS
authors.lastname: Hirsch
mesh_terms: D017977:Deltaretrovirus / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000494:pharmacology*; D007962:Leukocytes / Q000382:microbiology; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D007370:Interferon Type I