Serum estradiols versus pelvic sonography in monitoring HMG therapy.
Therapy with human menopausal gonadotropin (HMG) conventionally has been monitored by estrogen measurements. Pelvic sonography may offer a more accurate method of monitoring HMG therapy. In this study 67 anovulatory patients were treated with HMG until at least one follicle had a diameter of 17 mm. The serum estradiol level was noted at the time a mature follicle was achieved. There was a correlation between the ultrasound data and the serum estradiol range in 57% of the cases. However, in 24% it was necessary to push the estradiol level above the allowable maximum of 2000 pg/mL. Twenty percent of the patients attained a 17-mm follicle before reaching the minimum required estradiol level of 500 pg/mL. Sonographic monitoring should improve the efficacy of HMG therapy.
Check
J H
JH
Goldberg
B B
BB
Kurtz
A
A
Adelson
H G
HG
Dietterich
C
C
D000858:Anovulation / Q000097:blood / Q000188:drug therapy*; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D008596:Menotropins / Q000627:therapeutic use*; D010060:Ovulation / Q000187:drug effects; D010061:Ovulation Detection / Q000379:methods*; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011374:Progesterone / Q000627:therapeutic use; D014463:Ultrasonography
D011374:Progesterone; D004958:Estradiol; D008596:Menotropins