title: Disposition and urinary excretion of vecuronium bromide in anesthetized patients with normal renal function or renal failure.
abstract: The effect and plasma concentrations of vecuronium bromide were measured in normal patients after an intravenous dose of 50, 100, or 150 micrograms/kg and in patients with renal failure after 50 or 100 micrograms/kg. Urinary excretion of vecuronium was studied in normal patients after the 150 micrograms/kg dose. Pharmacokinetic parameters of patients with or without renal failure were similar. No metabolites of vecuronium were found in the plasma. Twenty percent of vecuronium was excreted unchanged in the urine; 5% as the 3-hydroxy derivative. No other metabolites of vecuronium were found in the urine. Increasing doses of vecuronium shortened the onset, but prolonged the duration of action and the recovery rate, to a similar extent in patients with or without renal failure. It was concluded that the disposition of vecuronium was best described by a three compartment model. Both the disposition and the effect of vecuronium are only marginally disturbed by renal failure.
authors.forename: A F
authors.initials: AF
authors.lastname: Bencini
authors.forename: A H
authors.initials: AH
authors.lastname: Scaf
authors.forename: Y J
authors.initials: YJ
authors.lastname: Sohn
authors.forename: C
authors.initials: C
authors.lastname: Meistelman
authors.forename: A
authors.initials: A
authors.lastname: Lienhart
authors.forename: U W
authors.initials: UW
authors.lastname: Kersten
authors.forename: S
authors.initials: S
authors.lastname: Schwarz
authors.forename: S
authors.initials: S
authors.lastname: Agoston
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007674:Kidney Diseases / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000378:metabolism*; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D014673:Vecuronium Bromide
chemical_list: D009466:Neuromuscular Blocking Agents; D014673:Vecuronium Bromide; D010197:Pancuronium