Cimetidine reverses tumor growth enhancement of plasmacytoma tumors in mice demonstrating conditioned immunosuppression.
Mice were given repeated injections, at 21 day intervals, of cyclophosphamide paired with a novel taste (saccharin) in the drinking water. Subsequent challenge with a syngeneic plasmacytoma tumor led to elevated tumor growth and mortality only in conditioned mice that were reexposed to saccharin. This effect was abolished by conditioned exposure to a histamine type II-receptor antagonist.
Gorczynski
R M
RM
Kennedy
M
M
Ciampi
A
A
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects; D003520:Cyclophosphamide / Q000008:administration & dosage; D004327:Drinking Behavior; D005260:Female; D006635:Histamine H2 Antagonists / Q000008:administration & dosage; D007130:Immunoglobulin Idiotypes / Q000378:metabolism; D007165:Immunosuppression Therapy / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D010954:Plasmacytoma / Q000276:immunology* / Q000401:mortality / Q000503:physiopathology; D011970:Receptors, Histamine H2 / Q000032:analysis; D012439:Saccharin / Q000008:administration & dosage; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism
D006635:Histamine H2 Antagonists; D007130:Immunoglobulin Idiotypes; D011970:Receptors, Histamine H2; D002927:Cimetidine; D003520:Cyclophosphamide; D012439:Saccharin