title: Proteolysis of liver acetyl coenzyme A carboxylase by cathepsin B.
abstract: Proteolysis of acetyl-CoA carboxylase was examined with cathepsin B. When chicken liver acetyl-CoA carboxylase was incubated with cathepsin B at pH 6.3, the native 220-kDa polypeptide was primarily cleaved into two polypeptides of 125 and 115 kDa, and further degraded to polypeptides of 100-50 kDa.
authors.forename: K
authors.initials: K
authors.lastname: Wada
authors.forename: T
authors.initials: T
authors.lastname: Tanabe
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000378:metabolism*; D000818:Animals; D002401:Cathepsin B; D002403:Cathepsins / Q000378:metabolism*; D002645:Chickens; D004591:Electrophoresis, Polyacrylamide Gel; D008025:Ligases / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008970:Molecular Weight; D010446:Peptide Fragments / Q000032:analysis
chemical_list: D010446:Peptide Fragments; D002403:Cathepsins; D002401:Cathepsin B; D008025:Ligases; D000103:Acetyl-CoA Carboxylase