Induction of anaesthesia with propofol ('Diprivan') or thiopentone and interactions with suxamethonium, atracurium and vecuronium.
A randomized study involving 60 healthy patients was performed to examine the induction characteristics and the possible interactions between propofol 2.5 mg/kg or thiopentone 4 mg/kg and three neuromuscular blocking agents, suxamethonium, atracurium and vecuronium. The time of onset to maximum blockade, the degree of blockade and the duration of blockade were measured using the electromyogram. The response to each muscle relaxant was not significantly different after induction of anaesthesia by propofol or thiopentone. A decrease in arterial blood pressure which occurred after both induction agents was greater after propofol than after thiopentone P less than 0.05. There was no significant difference in the increase in heart rate which occurred after the injection of either propofol or thiopentone.
Nightingale
P
P
Petts
N V
NV
Healy
T E
TE
Kay
B
B
McGuinness
K
K
D000328:Adult; D000771:Anesthesia, Intravenous; D001279:Atracurium; D001794:Blood Pressure / Q000187:drug effects; D004347:Drug Interactions; D004576:Electromyography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D010197:Pancuronium / Q000031:analogs & derivatives / Q000494:pharmacology; D010636:Phenols; D015742:Propofol; D013390:Succinylcholine / Q000494:pharmacology; D013874:Thiopental; D014673:Vecuronium Bromide
D007546:Isoquinolines; D009466:Neuromuscular Blocking Agents; D010636:Phenols; D001279:Atracurium; D014673:Vecuronium Bromide; D013390:Succinylcholine; D010197:Pancuronium; D013874:Thiopental; D015742:Propofol