Effects of clonixin, a non-steroidal analgesic, on the neurotransmission of the vas deferens of the rat.
1. The effect of C1X on the responses to TNS, ACh and NE in the isolated rat vas deferens was studied. 2. C1X produced a significant reduction of muscular twitch induced by TNS. 3. The M1-ACh response was significantly increased by this non-steroidal analgesic. 4. The M2-ACh response was not changed by pre-treatment with C1X. 5. The alpha 1-NE response was not altered by C1X. 6. The alpha 2-NE response was potentiated by pre-treatment with C1X. 7. The findings suggest that C1X beside its ability to block the release of NE, has some common pharmacological properties, close to those of a "calcium modulator".
Bustamante
D
D
Department of Pharmacology, Faculty of Medicine, Universidad de Chile, Santiago.
Miranda
H F
HF
Paeile
C
C
Wolstenholme
W W
WW
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003002:Clonixin / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000294:innervation*; D009539:Nicotinic Acids / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors; D014649:Vas Deferens / Q000294:innervation
D009539:Nicotinic Acids; D000109:Acetylcholine; D003002:Clonixin; D009638:Norepinephrine