title: [Characteristics of the immune response to a single peroral administration of different doses of corpuscular pertussis vaccine].
abstract: The effect of oral administrations of different doses of pertussis vaccine on the humoral and cell-mediated responses of systemic immunity and on the immunomorphological transformation of the mucous membrane of the small intestine was studied in (CBA X C57BL/6)F1 mice. On day 28 after the administration of all the tested doses of pertussis vaccine the animals were found to have a high degree of protection from the development of meningoencephalitis induced by the inoculation of Bordetella pertussis in the absence of specific hemagglutinins in their blood sera. At the same time the formation of spontaneous and immune rosette-forming cells and splenocytes was found to be inversely related to the administered dose. The immunomorphological transformation observed in the mucous membrane of the small intestine and in the lymphoid tissue associated with the small intestine was indicative of the stimulation of local immunity. The results thus obtained suggest that a single oral administration of pertussis vaccine to mice stimulates cell-mediated and humoral reactions of local immunity and induces the development of systemic cell-mediated immunity.
authors.forename: N S
authors.initials: NS
authors.lastname: Zakharova
authors.forename: V F
authors.initials: VF
authors.lastname: Salov
authors.forename: G S
authors.initials: GS
authors.lastname: Vlasov
authors.forename: I B
authors.initials: IB
authors.lastname: Shepeleva
authors.forename: G S
authors.initials: GS
authors.lastname: Sergeeva
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D001886:Bordetella pertussis / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D007111:Immunity, Cellular; D007114:Immunization; D007413:Intestinal Mucosa / Q000276:immunology; D007421:Intestine, Small / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology*; D012397:Rosette Formation; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D010567:Pertussis Vaccine
vernacular_title: Osobennosti immunnogo otveta pri odnokratnom peroral'nom vvedenii raznykh doz korpuskuliarnoĭ kokliushnoĭ vaktsiny.