title: [Natural peptides and their analogs. XXXV. Synthesis and properties of [Ala5, Orn9]somatostatin].
abstract: A total chemical synthesis of [Ala5, Orn9]somatostatin has been performed. This structural analogue of natural somatostatin inhibits the release of somatotropin, insulin and glucagon, but shows no inhibitory effect on secretion of prolactin.
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Shvachkin
authors.forename: A P
authors.initials: AP
authors.lastname: Smirnova
authors.forename: N M
authors.initials: NM
authors.lastname: Ermak
authors.forename: V P
authors.initials: VP
authors.lastname: Fedotov
authors.forename: N V
authors.initials: NV
authors.lastname: Sadovnikova
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002855:Chromatography, Thin Layer; D002942:Circular Dichroism; D005934:Glucagon / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D007328:Insulin; C049106:somatostatin, Ala(5)-Orn(9)-; D013004:Somatostatin; D011388:Prolactin; D013006:Growth Hormone; D005934:Glucagon
vernacular_title: Prirodnye peptidy i ikh analogi. XXXV. Sintez i svoĭstva [Ala5, Orn9]somatostatina.