title: Effect of dipyridamole on blood glucose and liver cyclic AMP levels and platelet count during endotoxaemia in mice.
abstract: 1. Blood glucose, liver cyclic AMP (cAMP) levels, and platelet count were studied at different times during a 12 h interval after intravenous (i.v.) endotoxin injection (40 mg/kg) in mice. 2. Blood glucose and liver cAMP levels showed a progressive decrease in endotoxic mice and the decrease was significant after 8 and 12 h. 3. Dipyridamole (50 mg/kg) administered intraperitoneally (i.p.) 7 h post-endotoxin improved blood glucose and liver cAMP levels. 4. Platelet counts were decreased after 1 h in endotoxic mice and remained decreased up to 8 h. Dipyridamole administered soon after endotoxin improved platelet counts in endotoxic mice and increased survival rate to 100%.
authors.affiliation: Department of Pharmacology, College of Medicine, Baghdad University, Iraq.
authors.forename: L M
authors.initials: LM
authors.lastname: Al-Jibouri
authors.forename: R A
authors.initials: RA
authors.lastname: Najim
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D004176:Dipyridamole / Q000494:pharmacology*; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010976:Platelet Count
chemical_list: D001786:Blood Glucose; D004731:Endotoxins; D004176:Dipyridamole; D000242:Cyclic AMP