The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization.
The Na+/H+ antiporter is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells. We cloned the human gene capable of complementing antiporter-deficient mouse fibroblasts and isolated an exon-containing genomic DNA fragment. Using this genomic probe, we mapped the putative structural gene of the amiloride-sensitive Na+/H+ antiporter to the human chromosome region 1p35----p36.1 by in situ hybridization.
Mattei
M G
MG
INSERM U242, Centre de Génétique Médicale, Hôpital d'enfants de la Timone, Marseille, France.
Sardet
C
C
Franchi
A
A
Pouysségur
J
J
D002352:Carrier Proteins / Q000235:genetics*; D002478:Cells, Cultured; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D005347:Fibroblasts; D005796:Genes; D006801:Humans; D008677:Metaphase; D009693:Nucleic Acid Hybridization; D017923:Sodium-Hydrogen Exchangers; D014162:Transfection
D002352:Carrier Proteins; D015342:DNA Probes; D017923:Sodium-Hydrogen Exchangers; D004247:DNA