Metabolic effects of dehydroabietic acid on rainbow trout erythrocytes.
Oxygen consumption and ATP concentration were measured in rainbow trout erythrocytes incubated in a physiological saline containing 0, 5, 15, 30 or 60 mg/l dehydroabietic acid. DHAA caused a decrease in cellular ATP level and oxygen consumption at concentrations above 15 mg/l. Haemolysis increased markedly, when the cellular ATP concentration decreased below 1 mM. These data suggest that increased breakdown of red cells may be the primary reason for jaundice which is observed in resin acid-toxicated fish.
Bushnell
P G
PG
Nikinmaa
M
M
Oikari
A
A
D045784:Abietanes; D000255:Adenosine Triphosphate / Q000097:blood; D000818:Animals; D004224:Diterpenes / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D007700:Kinetics; D010101:Oxygen Consumption / Q000187:drug effects; D014337:Trout
D045784:Abietanes; D004224:Diterpenes; D006454:Hemoglobins; C013913:dehydroabietic acid; D000255:Adenosine Triphosphate