Metergoline, naloxone, and sodium valproate did not modify arginine vasopressin response to insulin-induced hypoglycemia in man.
The present study was carried out in order to determine whether insulin-induced hypoglycemia exerts its stimulatory effect on plasma concentrations of arginine vasopressin (AVP) by interacting with a serotonergic, a GABA-ergic or an opioid pathway. For this purpose, the effect of the serotonergic antagonist metergoline (10 mg/day for 4 days po), the GABA-ergic agonist sodium valproate (600 mg in three divided doses po) and the opioid-receptor blocker naloxone (10 mg in a iv bolus) on the AVP response during an insulin (0.15 IU/kg bw) tolerance test (ITT) was evaluated in three groups of 6 normal men each. In all men, control ITTs were performed without drug treatments. Basal and ITT-stimulated AVP secretion was not modified by drug administration, suggesting that serotonergic, GABAergic and naloxone-sensitive opioid receptors are not involved in the regulation of AVP secretion in response to insulin-induced hypoglycemia.
Chiodera
P
P
Cattedra di Endocrinologia e Patologia Costituzionale, Università di Parma, Italy.
Gnudi
A
A
Volpi
R
R
d'Amato
L
L
Marchesi
C
C
Pioli
G
G
Muzzetto
P
P
Castelli
A
A
Bianconi
L
L
Minelli
R
R
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood*; D004873:Ergolines / Q000494:pharmacology*; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007003:Hypoglycemia / Q000097:blood* / Q000139:chemically induced; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D008711:Metergoline / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D014635:Valproic Acid / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D004873:Ergolines; D007328:Insulin; D001127:Arginine Vasopressin; D008711:Metergoline; D009270:Naloxone; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone