Therapeutic effect of pyrophosphate analogues on cutaneous herpes simplex virus type 1 infection in guinea pigs.
We investigated the influence of disodium phosphonic formate (PFA-Na2) and trisodium thiophosphonic formate (TPFA-Na3), in comparison with acyclovir (Zovirax) and trisodium phosphonic formate (PFA-Na3) (Triapten) ointment, on the course of primary cutaneous herpes simplex virus infection in a guinea pig skin model. PFA-Na2 at 3.0%, TPFA-Na3 at 0.5% and PFA-Na3 at 0.5% as well as Triapten ointment (2.0% PFA-Na3) completely inhibited virus infection. Zovirax cream (5.0% acyclovir), applied five times (15 min., 4, 20, 24, and 28 h) after virus inoculation did not prevent virus infection. Similarly, application of Zovirax cream 5 times daily for 5 days did not prevent a vesicle formation following cutaneous herpes simplex virus infection of the guinea pig.
Wutzler
P
P
Institute of Medical Microbiology, Medical Academy Erfurt, G.D.R.
Helbig
B
B
Ulbricht
A
A
Meerbach
A
A
Pradel
W
W
D000212:Acyclovir / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D011756:Diphosphates / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000188:drug therapy*; D008297:Male; D018139:Simplexvirus / Q000187:drug effects*; D012874:Skin Diseases, Infectious / Q000188:drug therapy*
D011756:Diphosphates; D000212:Acyclovir