Edrophonium and neostigmine for reversal of the neuromuscular blocking effect of vecuronium.
The effect of edrophonium for reversal of the non-depolarizing neuromuscular blockade produced by a continuous infusion of vecuronium was compared to that of neostigmine in 20 adult patients during neurolept anaesthesia. When antagonism was attempted at 10% twitch height recovery, reversal time to a train-of-four ratio of 0.7 was significantly shorter following neostigmine 0.04 mg/kg than after edrophonium 0.75 mg/kg (9.8 min and 18.7 min, respectively) but the same after edrophonium 1.5 mg/kg (10.3 min). There was no statistically significant difference in reversal time between neostigmine 0.04 mg/kg given at 10% twitch height and edrophonium 0.75 mg/kg given at 25% twitch height recovery (6.0 min). Additional doses of atropine were necessary following edrophonium 1.5 mg/kg.
Engbaek
J
J
Ording
H
H
Ostergaard
D
D
Viby-Mogensen
J
J
D000328:Adult; D004491:Edrophonium / Q000494:pharmacology*; D005260:Female; D006801:Humans; D010535:Laparoscopy; D009119:Muscle Contraction / Q000187:drug effects; D009388:Neostigmine / Q000494:pharmacology*; D009458:Neuroleptanalgesia; D009466:Neuromuscular Blocking Agents / Q000037:antagonists & inhibitors*; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D014673:Vecuronium Bromide
D009466:Neuromuscular Blocking Agents; D009388:Neostigmine; D004491:Edrophonium; D014673:Vecuronium Bromide; D010197:Pancuronium