Imipramine-flupenthixol decanoate interaction.
The authors describe a case in which flupenthixol decanoate and imipramine were co-administered to a patient with schizophrenia, resulting in extremely high levels of imipramine and its metabolite, desipramine. The literature on the co-administration of neuroleptics and antidepressants is reviewed and guidelines for limiting possible iatrogenic effects of the combination are suggested.
Cook
P E
PE
Dermer
S W
SW
Cardamone
J
J
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage; D014150:Antipsychotic Agents / Q000008:administration & dosage; D003891:Desipramine / Q000097:blood; D004347:Drug Interactions; D005475:Flupenthixol / Q000008:administration & dosage* / Q000031:analogs & derivatives; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage* / Q000097:blood; D008297:Male; D012563:Schizophrenia, Paranoid / Q000188:drug therapy*; D013892:Thioxanthenes / Q000008:administration & dosage*; D014196:Trazodone / Q000008:administration & dosage
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D013892:Thioxanthenes; C007761:flupenthixol decanoate; D005475:Flupenthixol; D007099:Imipramine; D003891:Desipramine; D014196:Trazodone