Tachycardia releases atrial natriuretic peptide in the anesthetized rabbit.
In anesthetized, vagotomized rabbits the plasma concentration of immunoreactive atrial natriuretic peptide (IR-ANP) was found to be 58.5 +/- 3.4 pg/mL (n = 18) when measured using a radio-immunoassay. Tachycardia, induced by electrical pacing of the right atrium, resulted in increased plasma levels of IR-ANP. The size of the increase in IR-ANP appeared to be related to the degree of tachycardia induced. The release of IR-ANP with tachycardia was unaffected by beta-adrenergic blockade with atenolol (2 mg/kg), muscarinic blockade with atropine (2 mg/kg) or ganglionic blockade with hexamethonium (10 mg/kg). The results show that IR-ANP is released in response to tachycardia and that this does not involve a neuronal reflex.
Rankin
A J
AJ
Courneya
C A
CA
Wilson
N
N
Ledsome
J R
JR
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001262:Atenolol / Q000494:pharmacology; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002304:Cardiac Pacing, Artificial; D006325:Heart Atria; D006339:Heart Rate / Q000187:drug effects; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D011817:Rabbits; D013610:Tachycardia / Q000097:blood* / Q000209:etiology
D006584:Hexamethonium Compounds; D018738:Hexamethonium; D001262:Atenolol; D001285:Atropine; D009320:Atrial Natriuretic Factor; D007545:Isoproterenol; D000109:Acetylcholine