[Effector modeling of the effect of ligands of GABA receptor complex. Modification of conformation states of the complex by combined administration of benzodiazepines and barbiturates].
The dynamics of the anticonvulsive effect (antagonism to the pharmacological effects of korazol, bicuculline, and picrotoxin) of sodium barbital, phenazepam, diazepam and their structural analogues was studied at their individual and combined administration. The indices of the combined pharmacological effect of barbiturates and benzodiazepines are not the summation of the pharmacologic effects of the compounds. The mutual influence of the effects of exogenic ligands--convulsive agents and anticonvulsive compounds was studied which can be considered as a result of the hyperbolic modification of three states of the GABA-receptor complex.
Zin'kovskiĭ
V G
VG
Golovenko
N Ia
NIa
Zhuk
O V
OV
D000818:Animals; D014151:Anti-Anxiety Agents; D001462:Barbital / Q000494:pharmacology; D001463:Barbiturates / Q000008:administration & dosage / Q000494:pharmacology*; D001569:Benzodiazepines / Q000008:administration & dosage / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004336:Drug Antagonism; D005260:Female; D008024:Ligands; D051379:Mice; D008954:Models, Biological; D010433:Pentylenetetrazole / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D001462:Barbital; D001463:Barbiturates; D001569:Benzodiazepines; D001570:Benzodiazepinones; D001640:Bicuculline; D003975:Diazepam; D008024:Ligands; D010433:Pentylenetetrazole; D010852:Picrotoxin; D011963:Receptors, GABA-A; C017928:phenazepam
Effektornoe modelirovanie deĭstviia ligandov GAMK-retseptornogo kompleksa. Modifikatsiia konformatsionnykh sostoianiĭ kompleksa pri sovmestnom vvedenii benzodiazepinov i barbituratov.