Ionophore A23187 stimulates Entamoeba histolytica to release prostaglandin F2 alpha.
High performance liquid chromatography and radioimmunoassay were used to identify the prostaglandins synthesized by Entamoeba histolytica (NIH:200 Strain). Ca2+ionophore A 23187 stimulated amebae produced elevated levels of prostaglandin F2 alpha when compared with the control cells. There were no significant differences in the levels of prostaglandin E2 and thromboxane B2. This is the first report of a stimulated non-mammalian cell producing prostaglandin F2 alpha.
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D000818:Animals; D000001:Calcimycin / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D015237:Dinoprost; D004748:Entamoeba histolytica / Q000378:metabolism*; D011460:Prostaglandins F / Q000096:biosynthesis*; D011863:Radioimmunoassay
D011460:Prostaglandins F; D000001:Calcimycin; D015237:Dinoprost