Relationship between growth inhibition and mitochondrial function in petite-negative yeasts. II. Effects of central nervous system drugs upon pathogenic and non-pathogenic Candida species.
Six nervous system drugs which inhibited vegetative reproduction of S. cerevisiae arrested also mitotic division of C. utilis, C. albicans and C. tropicalis. Chlorpromazine and chlorpheniramine which proved to be the most effective, affected respiration and cytochrome biosynthesis. Electrophoretic bands with MW congruent to 100 K were faint in silver-stained electrophoregrams of proteins from cells grown in the presence of a sub-inhibitory concentration of chlorpromazine.
Marmiroli
N
N
Tedeschi
F
F
Sabatini
M A
MA
Truzzi
G
G
Ferrari
C
C
Puglisi
P P
PP
D000639:Amitriptyline / Q000494:pharmacology; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002744:Chlorpheniramine / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D002997:Clomipramine / Q000494:pharmacology; D003580:Cytochromes / Q000096:biosynthesis; D004591:Electrophoresis, Polyacrylamide Gel; D007099:Imipramine / Q000494:pharmacology; D008928:Mitochondria / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D011395:Promazine / Q000494:pharmacology
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D003580:Cytochromes; D000639:Amitriptyline; D002744:Chlorpheniramine; D002997:Clomipramine; D011395:Promazine; D007099:Imipramine; D002746:Chlorpromazine