Treatment of asthma with an extempore combination of a bronchodilator, salbutamol, and a new antihistamine drug, oxatomide.
Forty patients suffering from asthmatic conditions, often accompanied by emphysema, were treated either with an extempore combination of salbutamol syrup plus 30-mg oxatomide tablets or with 30-mg oxatomide tablets alone for purposes of comparison. Greater efficacy was obtained with the combination, which produced positive results in terms of improved respiratory status, remission of clinical symptoms and reduced anti-asthma drug requirements in 90% of the cases treated, as against only 55% of satisfactory results obtained with oxatomide alone. The combination was very well tolerated with no incidence of adverse reactions, while the treatment with oxatomide alone, though on the whole well tolerated, gave rise to mild drowsiness in four cases.
Scremin
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Caprioglio
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D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000008:administration & dosage*; D011656:Pulmonary Emphysema / Q000150:complications; D011897:Random Allocation; D012129:Respiratory Function Tests; D012138:Respiratory Therapy; D013806:Theophylline / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D004338:Drug Combinations; D006634:Histamine H1 Antagonists; D010879:Piperazines; D013806:Theophylline; C015408:oxatomide; D000420:Albuterol