The importance of timing for the action of alpha 1- or beta-agonists: possible relationship with the density of [3H]prazosin and [3H]dihydroalprenolol binding sites.
Exploratory behaviour was measured in the open-field at 8.00 h and 20.00 h with naive rats and rats treated with an alpha 1-agonist (phenylephrine, 25 micrograms i.c.v.) or beta-agonists (salbutamol, 2.5 mg/kg; clenbuterol 0.05 mg/kg i.p.). The spontaneous activity was similar at both times, yet the response to a alpha 1-as well as to beta-stimulation was significantly enhanced at 20.00 h. The density of cortical [3H]prazosin and [3H]dihydroalprenolol ([3H]DHA) binding sites at 20.00 h was enhanced by 19% and 28% respectively, in comparison with the density measured at 8.00 h.
Mogilnicka
E
E
Wedzony
K
K
Klimek
V
V
Nowak
G
G
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000526:Alprenolol / Q000031:analogs & derivatives*; D000818:Animals; D001665:Binding Sites; D004082:Dihydroalprenolol / Q000378:metabolism*; D005106:Exploratory Behavior / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D011224:Prazosin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014316:Tritium
D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D014316:Tritium; D004082:Dihydroalprenolol; D000526:Alprenolol; D011224:Prazosin