title: Ascorbic acid antagonizes the behavioural effects of LSD in cats.
abstract: Pretreatment with ascorbic acid (500 mg kg-1 i.p.) antagonized the behavioural effects of lysergic acid diethylamide (LSD) and apomorphine, but not 5-methoxy-N,N-dimethyltryptamine, in cats. The data support the hypothesis that these behavioural effects in cats are due to drug action at both 5-HT and dopamine receptors, and that the action of LSD at dopamine receptors is modulated by ascorbic acid.
authors.forename: M E
authors.initials: ME
authors.lastname: Trulson
authors.forename: T
authors.initials: T
authors.lastname: Crisp
authors.forename: L J
authors.initials: LJ
authors.lastname: Henderson
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002415:Cats; D008238:Lysergic Acid Diethylamide / Q000037:antagonists & inhibitors*; D008732:Methoxydimethyltryptamines / Q000494:pharmacology
chemical_list: D008732:Methoxydimethyltryptamines; D008238:Lysergic Acid Diethylamide; D001058:Apomorphine; D001205:Ascorbic Acid