Displacement of striatal 5-hydroxytryptamine by dopamine released from endogenous stores.
Combined treatment with amfonelic acid and neuroleptics caused a considerable loss of striatal, but not cortical 5-hydroxytryptamine (5-HT) in rats. This could be prevented by pretreatment with the specific 5-HT uptake inhibitor, citalopram. The results are best explained by the assumption that the combined treatment with amfonelic acid and neuroleptic had massively released dopamine into the synaptic cleft, and a part of this had been taken up into the 5-HT neurons by the 5-HT uptake mechanism and displaced the indoleamine.
Waldmeier
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PC
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D009268:Nalidixic Acid / Q000031:analogs & derivatives; D009287:Naphthyridines / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*
D009287:Naphthyridines; D012701:Serotonin; D009268:Nalidixic Acid; D006220:Haloperidol; C006486:amfonelic acid; D004298:Dopamine