title: Sensitivity of a peptide-activated neuron in Aplysia to serotonin and cyclic AMP-relevant agents.
abstract: Serotonin depolarized Aplysia buccal motoneuron B16. The response could be obtained in high-magnesium/low-calcium medium, indicating a direct effect on B16 and supporting a putative monosynaptic input to B16 from the serotonergic metacerebral neurons. Similar depolarizing effects in high-magnesium/low-calcium medium were obtained in response to 8-bromo cyclic AMP, isobutylmethylxanthine, theophylline and forskolin. Tolbutamide, a putative inhibitor of cyclic AMP-dependent protein kinase, blocked or reversed responses of B16 to egg-laying hormone containing extracts and to serotonin. Serotonin and forskolin significantly increased the cyclic AMP content of buccal ganglia, whereas egg-laying hormone-containing extracts did not.
authors.forename: J L
authors.initials: JL
authors.lastname: Ram
authors.forename: K A
authors.initials: KA
authors.lastname: Haller
authors.forename: Z
authors.initials: Z
authors.lastname: Levran
mesh_terms: D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001048:Aplysia / Q000502:physiology*; D002610:Cheek / Q000378:metabolism; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*; D010761:Phosphorus Radioisotopes; D012701:Serotonin / Q000494:pharmacology*; D013997:Time Factors; D014044:Tolbutamide / Q000494:pharmacology
chemical_list: D009419:Nerve Tissue Proteins; D010761:Phosphorus Radioisotopes; D005576:Colforsin; D015124:8-Bromo Cyclic Adenosine Monophosphate; D012701:Serotonin; D014044:Tolbutamide; D000242:Cyclic AMP; D000262:Adenylyl Cyclases