[Effect of histamine and H1-receptor blockaders on bacterial endotoxin-induced thrombocyte aggregation].
Histamine and dimedrol exerted in vitro inhibitory effects on endotoxin-induced platelet aggregation. When administered at high concentrations pyrilamine potentiated aggregating influence of endotoxin. The experimental results indicate difference in effects of dimedrol and pyrilamine falling into the same group of H1-blockers in relation to induced platelet aggregation.
Shenkman
B Z
BZ
D000818:Animals; D004155:Diphenhydramine / Q000494:pharmacology; D004347:Drug Interactions; D004731:Endotoxins / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D011738:Pyrilamine / Q000494:pharmacology; D011817:Rabbits; D012764:Shigella sonnei
D004731:Endotoxins; D006634:Histamine H1 Antagonists; D006632:Histamine; D004155:Diphenhydramine; D011738:Pyrilamine
O vliianii gistamina i blokatorov H1-retseptorov na indutsirovannuiu bakterial'nym éndotoksinom agregatsiiu trombotsitov.