Reversal of isoproterenol-induced calorigenic action in the heart during myocardial ischemia.
With the aid of infrared thermography, a powerful new tool for studying the biological state of cardiac regulatory mechanisms, the reversal of the isoproterenol-induced calorigenic action in the in situ dog heart was demonstrated after establishing acute myocardial ischemia. The thermographic manifestations indicated a modified activity pattern of the cardiac (coronary) beta-mechanism with a preserved sensitivity to its specific pharmacologic blockade. Results provide new evidence of the transformation (plasticity) of adrenoceptor qualities under pathologic circumstances.
Juhász-Nagy
A
A
Cardiovascular Surgical Clinic, Semmelweis University Medical School, Budapest, Hungary.
Kékesi
V
V
Papp
L
L
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology; D013817:Thermography
D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol