Role of neurotransmitters in endosulfan-induced aggressive behaviour in normal and lesioned rats.
Normal and lesioned rats exposed to 3 mg/kg i.p. endosulfan for 10 subsequent days showed elevated foot-shock fighting behaviour in septal and nigral brain-lesioned animals. Increased ipsilateral circling was noticed in unilateral-nigral lesioned rats. A marked decrease in locomotor activity and no seizure pattern were recorded in rats treated with chlorpromazine (CPz). Electroencephalographic recording on the tenth day of endosulfan exposure showed high-voltage slow activity (HVSA) with occasional spindles and 5-6 Hz amplitude of 200 microV. In the treated rats an increase in the concentration of dopamine (DA) and a decrease in serotonin (5-HT) were recorded in amygdaloid, septal and nigral brain-lesioned rats.
Anand
M
M
Mehrotra
S
S
Gopal
K
K
Sur
R N
RN
Chandra
S V
SV
D000374:Aggression / Q000187:drug effects*; D000378:Agonistic Behavior / Q000187:drug effects*; D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D004569:Electroencephalography; D004726:Endosulfan / Q000494:pharmacology*; D005260:Female; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism
D018377:Neurotransmitter Agents; D012701:Serotonin; D004726:Endosulfan; D002746:Chlorpromazine; D004298:Dopamine