title: Immunological paralysis to pneumococcal polysaccharide in man.
abstract: A 9-month-old infant had severe pneumococcal meningitis and for the next two years showed immunological paralysis to the causal serotype. He remained normally responsive to a protein antigen (tetanus toxoid) and to polysaccharide antigens (Haemophilus influenzae type b capsule and pneumococcal capsule antigens other than the infecting/paralysing serotype). By the fourth year of life the child was spontaneously producing antibody to the infecting/paralysing pneumococcal serotype, at which time rechallenge with the previously tolerising antigen resulted in a secondary response. The occurrence of pneumococcal immunological paralysis in man is therefore validated.
authors.forename: M E
authors.initials: ME
authors.lastname: Pichichero
mesh_terms: D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial / Q000652:urine; D001428:Bacterial Vaccines / Q000276:immunology; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007108:Immune Tolerance; D007223:Infant; D008297:Male; D008586:Meningitis, Pneumococcal / Q000276:immunology* / Q000628:therapy; D022242:Pneumococcal Vaccines; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D022242:Pneumococcal Vaccines; D011135:Polysaccharides, Bacterial