Evidence for crossed catecholaminergic nigrostriatal projections by combining wheat germ agglutinin-horseradish peroxidase retrograde transport and tyrosine hydroxylase immunocytochemistry.
After unilateral injections of wheat germ agglutinin-horseradish peroxidase into the rat caudate-putamen, a few retrogradely labeled neurons were found in the contralateral pars compacta of the substantia nigra. These contralaterally projecting nigral cell bodies also immunoreacted positively to a specific tyrosine hydroxylase antiserum. We conclude that crossed catecholaminergic nigrostriatal projections may contribute to the reciprocal regulation exerted by the two nigrostriatal dopaminergic systems.
Consolazione
A
A
Bentivoglio
M
M
Goldstein
M
M
Toffano
G
G
D000818:Animals; D001692:Biological Transport; D001921:Brain / Q000033:anatomy & histology; D001923:Brain Chemistry; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000032:analysis*; D006735:Horseradish Peroxidase; D007124:Immunoenzyme Techniques; D037102:Lectins; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology; D051381:Rats; D013378:Substantia Nigra / Q000502:physiology*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis*; D014909:Wheat Germ Agglutinins
D037102:Lectins; D014909:Wheat Germ Agglutinins; D006735:Horseradish Peroxidase; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine