Phosphoinositide turnover and calcium ion mobilization in receptor activation.
Ca2+ is now recognized to play a central role in the cellular signal transduction system. The hydrolysis of inositol phospholipids is an initial and essential event in Ca2+-mobilizing receptor activation. Phospholipase C cleaves phosphatidylinositol 4,5-bisphosphate to yield two intracellular messengers: inositol 1,4,5-trisphosphate that mobilizes Ca2+ from intracellular storage sites, and 1,2-diacylglycerol that activates protein kinase C. In this chapter, I will describe the functional role of phosphoinositide breakdown during receptor activation and the regulatory mechanism of phospholipase C.
Nozawa
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Department of Biochemistry, Gifu University School of Medicine, Japan.
D000818:Animals; D002118:Calcium / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate; D007295:Inositol Phosphates / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D011953:Receptors, Cyclic AMP / Q000378:metabolism; D010738:Type C Phospholipases / Q000378:metabolism
D007295:Inositol Phosphates; D010716:Phosphatidylinositols; D011953:Receptors, Cyclic AMP; D015544:Inositol 1,4,5-Trisphosphate; D000242:Cyclic AMP; D011493:Protein Kinase C; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins; D002118:Calcium