(-)-Pindolol stereospecifically inhibits rat brain serotonin (5-HT) synthesis.
(-)-Pindolol (4 mg/kg, i.p.) stereospecifically and selectively inhibited rat brain 5-HT synthesis. The DA and NA synthesis remained unaffected by pindolol (either enantiomer) treatment, and the (-)-pindolol-induced decrease in 5-HT synthesis was not prevented by reserpine pretreatment. The results indicate that, in addition to its beta-adrenergic properties, (-)-pindolol may act as an agonist at synthesis-controlling 5-HT receptors (autoreceptors ?) in the rat CNS.
Hjorth
S
S
Carlsson
A
A
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D003864:Depression, Chemical; D004298:Dopamine / Q000096:biosynthesis; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D010869:Pindolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000096:biosynthesis*; D013237:Stereoisomerism
D000319:Adrenergic beta-Antagonists; D012701:Serotonin; D012110:Reserpine; D010869:Pindolol; D004298:Dopamine; D009638:Norepinephrine