title: [Improved diagnosis using deuterated radiopharmaceuticals?--A comparison of the brain affinity of amphetamine analogs].
abstract: Ruthenocene amphetamine analogues have the same brain uptake as iodo-labelled amphetamines. This paper compares the organ-distribution of 103Ru labelled ruthenocene- or ferrocene-amphetamine analogues in mice and rats with the same amphetamine in which H-atoms were partly substituted by D-atoms. The uptake in the brain is increased up to 180-200% for deuterium substituted compounds. The pattern of excreted metabolites leads to the conclusion that the deuterated amphetamines are more slowly metabolised than normal (H) compounds.
authors.affiliation: Pharmazeutisches Institut der Freien Universität Berlin, F.R.G.
authors.forename: M
authors.initials: M
authors.lastname: Wenzl
authors.forename: M
authors.initials: M
authors.lastname: Langstaedtler
authors.forename: D
authors.initials: D
authors.lastname: Preiss
mesh_terms: D000661:Amphetamine / Q000493:pharmacokinetics; D000662:Amphetamines / Q000493:pharmacokinetics; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D005296:Ferrous Compounds / Q000493:pharmacokinetics; D000075163:Metallocenes; D051379:Mice; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D012429:Ruthenium Radioisotopes / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D000662:Amphetamines; D005296:Ferrous Compounds; D000075163:Metallocenes; D009942:Organometallic Compounds; D012429:Ruthenium Radioisotopes; C050321:ruthenocene-N-isopropylamphetamine; C016721:ruthenocene; D000661:Amphetamine; C004998:ferrocene
vernacular_title: Verbesserte Diagnostik durch deuterierte Radiopharmaka?--Vergleich der Gehirn-Affinität von Amphetamin-Analoga.