[Myocardial blood supply under different degrees of emotional excitation and the pathophysiological characteristics of the mechanisms of its adaptation].
Emotional stress was stimulated by placing rats in a tight cage (moderate stress) or fixing them rigidly on a bench (marked stress) for 1 hour. In moderate emotional stress, the coronary fraction of cardiac output and effective myocardial blood supply declined considerably. Marked emotional stress caused a similar reduction in the cardiac output coronary fraction, whereas effective myocardial blood supply was not reduced, but, on the contrary, tended to increase. The decrease in coronary fraction was not related to adrenergic effects. Marked emotional stress provoked regional changes in the resistance, microcirculatory and capacity components of the vascular bed, an adaptation to enable effective myocardial blood supply and enhance cardiac activity. It was accompanied with kallikrein-kinin activation.
Kovalev
O A
OA
Korovin
K F
KF
Nepochatov
O N
ON
Parfenova
M A
MA
Radchenko
E R
ER
D000222:Adaptation, Physiological / Q000187:drug effects; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001811:Blood Volume Determination / Q000379:methods; D001950:Bretylium Tosylate / Q000494:pharmacology; D002712:Chlorides; D003326:Coronary Circulation / Q000187:drug effects; D004146:Dioxanes / Q000494:pharmacology; D006801:Humans; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D011868:Radioisotopes; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects; D012149:Restraint, Physical; D012413:Rubidium; D012711:Serum Albumin, Radio-Iodinated; D013315:Stress, Psychological / Q000503:physiopathology*; D013565:Sympatholytics / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D002712:Chlorides; D004146:Dioxanes; D011868:Radioisotopes; D011941:Receptors, Adrenergic; D012711:Serum Albumin, Radio-Iodinated; D013565:Sympatholytics; D001950:Bretylium Tosylate; D011433:Propranolol; D012413:Rubidium; C032710:rubidium chloride; C009143:proroxan
Krovosnabzhenie miokarda pri razlichnoĭ stepeni émotsional'nogo vozbuzhdeniia i patofiziologicheskaia kharakteristika nekotorykh mekhanizmov ego adaptatsii.