The effect of abdominal radiation on spleen function: a study in children with Wilms' tumor.
Reports of splenic dysfunction in patients with Hodgkin's disease who received radiation therapy to the spleen raise questions concerning impairment of splenic function and the long-term risk of bacterial sepsis in children who receive abdominal radiation for other diseases. Splenic function was studied in 20 children with Wilms' tumor using a quantitative assessment of vacuolated ("pitted") red cells as a measure of reticuloendothelial function. Fourteen children had received abdominal radiation to a field involving the spleen at a median dose of 2000 rads. Their pitted red cells counts were no different from those of 6 children who received therapy without radiation to the spleen or to those of a group of normal children and adults. We conclude that there is no demonstrable long-term impairment of spleen function with radiation doses at or below 2200 rads.
Stevens
M
M
Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.
Brown
E
E
Zipursky
A
A
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004912:Erythrocytes / Q000648:ultrastructure; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D012157:Mononuclear Phagocyte System / Q000503:physiopathology / Q000528:radiation effects; D012189:Retrospective Studies; D013154:Spleen / Q000503:physiopathology / Q000528:radiation effects*; D013156:Splenectomy; D014617:Vacuoles; D009396:Wilms Tumor / Q000188:drug therapy / Q000532:radiotherapy*