title: Insulinoma and subclinical peripheral neuropathy in two dogs.
abstract: Two dogs with diffuse, subclinical polyneuropathy associated with insulinoma are reported. Seizures were the dominant sign of central nervous system disease. One dog had clinical signs of facial nerve paralysis. Lesions in selected appendicular and cranial nerves included a mixture of demyelination, remyelination, and axonal degeneration. The incidence (range: 18-47%) of these changes far exceeded that of comparable nerves from six control dogs (range 0-11%). Myopathic and electrodiagnostic findings were compatible with the nerve changes.
authors.affiliation: Neuromuscular Laboratory, Scott-Ritchey Research Program, Auburn University, Alabama 36849.
authors.forename: K G
authors.initials: KG
authors.lastname: Braund
authors.forename: J E
authors.initials: JE
authors.lastname: Steiss
authors.forename: K A
authors.initials: KA
authors.lastname: Amling
authors.forename: M
authors.initials: M
authors.lastname: Toivio-Kinnucan
authors.forename: L C
authors.initials: LC
authors.lastname: Case
authors.forename: R J
authors.initials: RJ
authors.lastname: Kemppainen
authors.forename: E S
authors.initials: ES
authors.lastname: Coleman
mesh_terms: D007516:Adenoma, Islet Cell / Q000662:veterinary*; D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D007340:Insulinoma / Q000150:complications / Q000662:veterinary*; D008297:Male; D010190:Pancreatic Neoplasms / Q000150:complications / Q000662:veterinary*; D010525:Peripheral Nerves / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000662:veterinary*