Human anti-luteinizing hormone-releasing hormone antibodies in patients treated with synthetic luteinizing hormone-releasing hormone.
One hundred sixty-three patients who were given synthetic LH-RH therapeutically underwent monitoring of serum IgG anti-LH-RH antibodies. Five of the patients showed specific binding to antibodies. Development of anti-LH-RH antibodies was not limited to those patients with a congenital deficiency of LH-RH. Urticarial responses occurred in four patients, only one of whom had IgG antibodies. Patients who had IgG antibodies or an urticarial response underwent monitoring of their serum IgE anti-LH-RH antibodies, but none had a positive binding response. The refractory state which has been reported in patients in whom similar antibodies to LH-RH develop was not invariably observed among these patients.
Meakin
J L
JL
Keogh
E J
EJ
Martin
C E
CE
D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy; D000906:Antibodies / Q000032:analysis*; D000937:Antigen-Antibody Reactions; D002648:Child; D002675:Child, Preschool; D003456:Cryptorchidism / Q000188:drug therapy; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000276:immunology* / Q000627:therapeutic use; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy; D008297:Male; D014581:Urticaria / Q000209:etiology*
D000906:Antibodies; D007987:Gonadotropin-Releasing Hormone