[Distribution of the 14C-hydrated analog of phenazepam in the organs and tissues of mice].
The absorption kinetics of hydrated phenazepam analog into the liver, spleen, brain, kidney, blood, lungs, heart, skeletal and fat tissues is studied at 0.25-24 hour intervals after its intraperitoneal (i/p) administration to mice. Drug concentration in the above mentioned organs was maximal 0.5-1 hour later. The decrease of the drug and its metabolite level in the organs under study is a biexponential process, consisting of "quick" (1-6 hours) and "slow" phases. The rate of absorption of hydrated phenazepam analog into the organs and tissues and its elimination is lower than that of phenanzepam.
Golovenko
N Ia
NIa
Sozinov
V A
VA
Rudenko
O P
OP
D000042:Absorption; D000818:Animals; D014151:Anti-Anxiety Agents / Q000378:metabolism*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000378:metabolism*; D002250:Carbon Radioisotopes; D007700:Kinetics; D008297:Male; D051379:Mice; D013997:Time Factors; D014018:Tissue Distribution
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D002250:Carbon Radioisotopes; D001569:Benzodiazepines; C017928:phenazepam
Raspredelenie 14C-gidrirovannogo analoga fenazepama v nekotorykh organakh i tkaniakh mysheĭ.