Immunopharmacology and immunotoxicity of zinc diethyldithiocarbamate.
Zinc is essential for the functions of the immune system, and sodium diethyldithiocarbamate (imuthiol) restores and regulates the numbers and activities of cells of the T-cell lineage. The combination of both elements was therefore tested for immune enhancement and immunotoxicity. The data presented herein show that the administration of zinc diethyldithiocarbamate was devoid of immunoenhancing influence on the responses to T-cell mitogens, and exerted a cytocidal effect on spleen lymphocytes.
Renoux
G
G
Laboratoire d'Immunologie, Faculté de Médicine, Tours, France.
Renoux
M
M
Guillaumin
J M
JM
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004050:Ditiocarb / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects; D015032:Zinc / Q000494:pharmacology* / Q000633:toxicity
D000276:Adjuvants, Immunologic; D004050:Ditiocarb; D015032:Zinc