Isolation of a new aloe-emodin dianthrone diglucoside from senna and its potentiating effect on the purgative activity of sennoside A in mice.
Two aloe-emodin dianthrone diglucosides (I and II) were isolated from the leaves of Cassia angustifolia Vahl by successive column chromatography with Amberlite XAD-2, silica gel, Polyamide C-200 and Sephadex LH-20. The stereostructures of I and II were elucidated as trans and meso isomers at 10-10', respectively, from the patterns of the ultraviolet absorption spectra and circular dichroism curves. This is the first report of isolation of diglucoside I from senna. Despite the lack of purgative activity, diglucoside I exerts a potentiating effect of about 1.3 times on the purgative activity of sennoside A in mice when even 15% is included in the mixture. The difference between I and a third active glycoside based on aloe-emodin is also discussed.
Nakajima
K
K
Yamauchi
K
K
Kuwano
S
S
D000504:Aloe / Q000032:analysis; D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D002942:Circular Dichroism; D004357:Drug Synergism; D004639:Emetics; D005260:Female; D005960:Glucosides; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008813:Mice, Inbred ICR; D010946:Plants, Medicinal; D012676:Senna Extract / Q000032:analysis*; D000081226:Sennosides; D013056:Spectrophotometry, Ultraviolet
D000880:Anthraquinones; D004639:Emetics; D005960:Glucosides; D000081226:Sennosides; D012676:Senna Extract; C047621:aloe-emodin dianthrone diglucoside