Effects of aspirin on gastric mucus glycoprotein in fed and fasted rats.
Gastric lesions induced by aspirin increased the ulcer index and incidence with prolongation of fasting time. Aspirin decreased gastric mucus glycoprotein in both the corpus and antrum. However, the rate of decrease in mucus glycoprotein induced by aspirin differed according to feeding habits and the gastric region. Qualitative change in corpus mucus glycoprotein was induced by aspirin.
Ohara
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Hotta
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D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D002241:Carbohydrates / Q000032:analysis; D004435:Eating; D005215:Fasting; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006023:Glycoproteins / Q000302:isolation & purification / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002241:Carbohydrates; D006023:Glycoproteins; C047874:gastric mucus glycoproteins; D001241:Aspirin