title: Positron emission tomography in schizophrenic patients with and without neuroleptic medication.
abstract: Positron emission tomography using [18F]2-fluoro-2-deoxy-D-glucose was performed in nine chronic schizophrenic patients both when medication-free and when medicated with neuroleptics. Total brain cortex, temporal cortex, and basal ganglia glucose use was significantly increased with medication; however, there was no change in anterior/posterior metabolic gradients.
authors.forename: L E
authors.initials: LE
authors.lastname: DeLisi
authors.forename: H H
authors.initials: HH
authors.lastname: Holcomb
authors.forename: R M
authors.initials: RM
authors.lastname: Cohen
authors.forename: D
authors.initials: D
authors.lastname: Pickar
authors.forename: W
authors.initials: W
authors.lastname: Carpenter
authors.forename: J M
authors.initials: JM
authors.lastname: Morihisa
authors.forename: A C
authors.initials: AC
authors.lastname: King
authors.forename: R
authors.initials: R
authors.lastname: Kessler
authors.forename: M S
authors.initials: MS
authors.lastname: Buchsbaum
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002421:Caudate Nucleus / Q000378:metabolism; D002908:Chronic Disease; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy / Q000378:metabolism*; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D014150:Antipsychotic Agents; D005947:Glucose