Gastrointestinal colonization and septicaemia with Pseudomonas aeruginosa due to contaminated thymol mouthwash in immunocompromised patients.
An outbreak of septicaemia with Pseudomonas aeruginosa amongst adult men with haematological malignancy involved eight patients on the same ward during a period of 5 weeks. The strains isolated from blood cultures from seven patients were indistinguishable by conventional typing methods. Thymol mouthwash which had been made up and distributed in communal jugs was found to be contaminated with the epidemic strain and was the likely source for this outbreak. A high rate of gastrointestinal colonization with the epidemic strain was found in the patients receiving the contaminated mouthwash. Only those patients with prolonged severe leucopenia developed septicaemia. Communal medications are an unnecessary hazard, particularly in oncology wards.
Stephenson
J R
JR
Heard
S R
SR
Richards
M A
MA
Tabaqchali
S
S
D000293:Adolescent; D000328:Adult; D003428:Cross Infection / Q000209:etiology; D004196:Disease Outbreaks; D006801:Humans; D007970:Leukopenia / Q000150:complications; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes; D011552:Pseudomonas Infections / Q000209:etiology*; D012007:Rectum / Q000382:microbiology*; D018805:Sepsis / Q000382:microbiology*; D013943:Thymol
D009067:Mouthwashes; D013943:Thymol