title: Serotonin regulation of aldosterone secretion.
abstract: The circulating levels of aldosterone (A), cortisol (F), prolactin, ACTH and potassium and the PRA were studied in 8 (6 males and 2 females) healthy normotensive subjects after 5-hydroxy-tryptophan (5OHT), or pizotifen (Piz) or placebo oral administration. In the same subjects 5OHT was administered twice: after placebo and after dexamethasone pretreatment. The results showed a significant increase of A, ACTH and F after 5OHT plus placebo administration without any change of PRA, potassium or prolactin levels; dexamethasone pretreatment suppressed ACTH and F but was uneffective on the response of A to 5OHT. Only A levels showed a significant decrease after Piz administration, the other studied parameters were unaffected by the blockade of the 5HT2 receptors by Piz. The administration of placebo induced a slight but not significant decrease of the studied parameters. Our results suggest the existence of a physiologic serotonergic control of A secretion, a pituitary factor could be one of the putative links between the central serotonergic activation and the adrenal secretory response.
authors.affiliation: University of Parma, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Maestri
authors.forename: L
authors.initials: L
authors.lastname: Camellini
authors.forename: G
authors.initials: G
authors.lastname: Rossi
authors.forename: G P
authors.initials: GP
authors.lastname: Rossi
authors.forename: C
authors.initials: C
authors.lastname: Dotti
authors.forename: M
authors.initials: M
authors.lastname: Marchesi
authors.forename: A
authors.initials: A
authors.lastname: Gnudi
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010918:Pizotyline / Q000494:pharmacology*; D011188:Potassium / Q000097:blood; D011388:Prolactin / Q000097:blood; D012083:Renin / Q000097:blood; D012701:Serotonin / Q000502:physiology*; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D013876:Thiophenes; D010918:Pizotyline; D012701:Serotonin; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D006916:5-Hydroxytryptophan; D012083:Renin; D011188:Potassium; D006854:Hydrocortisone