Metronidazole neuropathy: a case report.
A 67-year-old man developed peripheral neuropathy characterized by glove and stocking type sensory disturbances after the ingestion of 101.25 g of metronidazole for hepatic amebiasis. The clinical pictures of metronidazole-induced neuropathy appears to be the same as that of myeloneuropathy. The morphological study of a sural nerve biopsy showed a severe loss of myelinated fibers (2,400 per mm2). The density of unmyelinated fibers was at a lower limit of the normal range (23,530 per mm2). Electronmicroscopy confirmed the axonal degeneration of both the myelinated fibers and unmyelinated fibers.
Takeuchi
H
H
Department of Internal Medicine, Kagawa Medical School, Japan.
Yamada
A
A
Touge
T
T
Miki
H
H
Nishioka
M
M
Hashimoto
S
S
D000368:Aged; D001369:Axons / Q000648:ultrastructure; D001706:Biopsy; D004576:Electromyography; D006801:Humans; D008101:Liver Abscess, Amebic / Q000188:drug therapy*; D008297:Male; D008795:Metronidazole / Q000009:adverse effects* / Q000627:therapeutic use; D009132:Muscles / Q000294:innervation; D009469:Neuromuscular Junction / Q000187:drug effects; D010525:Peripheral Nerves / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology; D009435:Synaptic Transmission / Q000187:drug effects
D008795:Metronidazole