title: Pharmacokinetics and initial distribution of a new neuroleptic agent picobenzide (M-14012-4).
abstract: The pharmacokinetics of picobenzide was studied in 14 adult patients undergoing neuroleptoanalgesic sessions. The dose of picobenzide administered was 10 mg/kg by i.v. injection. The pharmacokinetic parameters obtained revealed a good distribution capacity with an average value of the apparent distribution volume at steady state of 28.29 +/- 4.98 1. The drug was also seen to be eliminated rapidly from the organism with an average value of the serum half-life of 2.05 +/- 0.42 h. The determination of the initial distribution kinetics of picobenzide shows that the use of a conventional kinetic model induces an overestimation of the initial distribution volume in turn caused by an underestimation of the initial serum concentration.
authors.forename: M V
authors.initials: MV
authors.lastname: Calvo
authors.forename: M A
authors.initials: MA
authors.lastname: Nalda
authors.forename: J M
authors.initials: JM
authors.lastname: Lanao
authors.forename: A
authors.initials: A
authors.lastname: Dominguez-Gil
authors.forename: S
authors.initials: S
authors.lastname: Carrasco
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000378:metabolism*; D001549:Benzamides / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D014018:Tissue Distribution
chemical_list: D014150:Antipsychotic Agents; D001549:Benzamides; C016938:picobenzide