title: Relationship between cerebrospinal fluid somatostatin and peripheral thyroid hormones with carbamazepine treatment.
abstract: The relationship between CSF somatostatin and peripheral thyroid hormones was assessed in 11 affectively ill patients before and during carbamazepine treatment. A direct relationship between CSF somatostatin and plasma thyroxine and free thyroxine, but not triiodothyronine, was observed both while patients were medication-free and during carbamazepine treatment. These first data in man are consistent with those in animals, suggesting a close interrelationship between somatostatin and thyroid regulation.
authors.forename: R T
authors.initials: RT
authors.lastname: Joffe
authors.forename: D R
authors.initials: DR
authors.lastname: Rubinow
authors.forename: R M
authors.initials: RM
authors.lastname: Post
authors.forename: T W
authors.initials: TW
authors.lastname: Uhde
mesh_terms: D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D002220:Carbamazepine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013004:Somatostatin / Q000134:cerebrospinal fluid*; D013963:Thyroid Hormones / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D013963:Thyroid Hormones; D014284:Triiodothyronine; D002220:Carbamazepine; D013004:Somatostatin; D013974:Thyroxine