Attrition of trisomies as a maternal screening device. An explanation of the association of trisomy 21 with maternal age.
Analysis of published data indicates that the increased rate of trisomy 21 pregnancies with advancing maternal age is due to failure of a postulated maternal screening process between fertilisation and recognition. This mechanism may also operate in other trisomies.
Stein
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Stein
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Susser
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D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D004314:Down Syndrome / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D005306:Fertilization; D006801:Humans; D008297:Male; D008423:Maternal Age; D008875:Middle Aged; D008957:Models, Genetic; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D011336:Probability; D012641:Selection, Genetic; D014314:Trisomy