title: L-643.441: an H2-receptor antagonist with potent and long-lasting effects in man.
abstract: Submaximal dose pentagastrin tests conducted in normal male volunteers with L-643.441, a novel histamine H2-receptor antagonist, indicate that it is a potent and long-acting inhibitor of gastric acid secretion. The effect appears dose-dependent and single doses of 50 mg are sufficient to reduce secretory potential by at least 50% when examined 24 h after drug administration. No adverse effects attributable to treatment were observed.
authors.forename: D A
authors.initials: DA
authors.lastname: Henry
authors.forename: K W
authors.initials: KW
authors.lastname: Somerville
authors.forename: G K
authors.initials: GK
authors.lastname: Kitchingman
authors.forename: I B
authors.initials: IB
authors.lastname: Holmes
authors.forename: J A
authors.initials: JA
authors.lastname: Tobert
authors.forename: M J
authors.initials: MJ
authors.lastname: Langman
mesh_terms: D000328:Adult; D055598:Chemical Phenomena; D002621:Chemistry; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism*; D006635:Histamine H2 Antagonists; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000037:antagonists & inhibitors; D013830:Thiadiazoles / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D006635:Histamine H2 Antagonists; D013830:Thiadiazoles; C037400:L 643441; D010418:Pentagastrin