Electroconvulsive shock and reserpine increase alpha 1-adrenoceptor binding sites but not norepinephrine-stimulated phosphoinositide hydrolysis in rat brain.
Repeated treatment of rats with either electroconvulsive shock or reserpine increased the density of alpha 1-adrenoceptor binding sites labeled by [3H]prazosin in rat frontal cerebral cortex. In contrast, norepinephrine-stimulated phosphoinositide hydrolysis, which is mediated by alpha 1-adrenoceptors, was not significantly affected by either treatment. These data suggest that electroconvulsive shock and reserpine might increase only or predominantly a subtype of alpha 1-adrenoceptor that is not coupled to phosphoinositide hydrolysis.
Blendy
J A
JA
Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20007.
Stockmeier
C A
CA
Kellar
K J
KJ
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D004597:Electroshock; D006868:Hydrolysis; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000378:metabolism*; D011224:Prazosin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D012110:Reserpine / Q000494:pharmacology*
D010716:Phosphatidylinositols; D011942:Receptors, Adrenergic, alpha; D012110:Reserpine; D009638:Norepinephrine; D011224:Prazosin