Inhibition of hypothermic effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788, in mice.
Intracisternally administered cholecystokinin produced long lasting hypothermia in mice, and the hypothermic effect was significantly antagonized by benzodiazepines like chlordiazepoxide and diazepam and by a benzodiazepine antagonist, Ro 15-1788, that were administered intraperitoneally. Proglumide, a cholecystokinin antagonist, failed to prevent the hypothermia induced by cholecystokinin at a dose of 200 mg/kg. Benzodiazepines and Ro 15-1788 revealed a considerably strong hypothermic effect, but they still prevented the hypothermic effect of cholecystokinin. The precise mechanism of the antagonism between cholecystokinin and benzodiazepines remains unclear at present.
Sugaya
K
K
Matsuda
I
I
Kubota
K
K
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005442:Flumazenil; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D011377:Proglumide / Q000494:pharmacology; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D009270:Naloxone; D005442:Flumazenil; D002766:Cholecystokinin; D011377:Proglumide