Antibodies to poliomyelitis virus in cord blood of neonates born to from mothers in contact or not in contact with the wild virus.
Neutralizing antibodies to polioviruses in cord blood of neonates born from 64 mothers under age 20 and in 53 mothers aged 30 years and over were investigated in order to know and compare the transfer to newborns of antibodies to polioviruses produced by live oral vaccine mainly and those antibodies induced by natural contact with wild poliovirus strains. Total immunity for the two groups was higher than 80% for the three types of polioviruses, with only virus 3 showing an immunity below 80% (77.4%) in mothers aged 30 years and over. Average geometric titers though relatively low may be considered satisfactory. However, there is a statistically significant difference in titers to poliovirus type 2 (24.9) in mothers over age 30 years as compared to those found in mothers below age 20 years (10.8), for which we have found no explanation. It is not deemed necessary for the time being to take special prophylactic measures with these children given the occurrent epidemiologic status quo.
Lago
P M
PM
National Institute of Hygiene, Epidemiology and Microbiology, Havana, Cuba.
Escobar
W A
WA
Hernández
P R
PR
Elías
M J
MJ
Puente
R P
RP
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D003462:Cuba; D004812:Epidemiologic Methods; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007112:Immunity, Maternally-Acquired; D007231:Infant, Newborn; D008423:Maternal Age; D017955:Poliovirus / Q000276:immunology*; D011055:Poliovirus Vaccine, Oral / Q000627:therapeutic use; D011247:Pregnancy
D000914:Antibodies, Viral; D011055:Poliovirus Vaccine, Oral