Effects of taurine and verapamil on heart calcium in hamsters and rats.
Heart calcium was measured in hamsters and rats following 30 days of drinking (i) tap water, (ii) taurine solution (T) or (iii) a taurine uptake inhibitor (GES). The regimes were duplicated in animals receiving verapamil (V). Heart calcium was reduced in both species by T + V; a comparable effect was obtained with GES alone; T alone had no effect. In the hamster, the GES effect was reversed by GES + V; V alone had no effect. In rats, the separate and combined effects of GES and V on heart calcium were identical. Possible mechanisms and underlying species differences are discussed.
McBroom
M J
MJ
Welty
J D
JD
D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D006224:Cricetinae; D006321:Heart / Q000187:drug effects*; D008647:Mesocricetus; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013654:Taurine / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology*
D013654:Taurine; D014700:Verapamil; D002118:Calcium