title: Chicken-activated-T-lymphocyte-antigen (CATLA) recognized by monoclonal antibody INN-CH 16 represents the IL-2 receptor.
abstract: Monoclonal antibody INN-CH 16 recognizes a surface determinant exclusively present on activated chicken T lymphocytes. The present experiments suggest that this chicken activated T lymphocyte antigen (CATLA) represents the chicken IL-2 receptor or an associated structure, as (i) the kinetics of CATLA expression during T cell activation are analogous to those described for the mammalian receptor for IL-2, (ii) the IL-2 dependent proliferation of mitogen prestimulated chicken lymphocytes is competitively inhibited by INN-CH 16, and (iii) pretreatment of T lymphoblasts with INN-CH 16 drastically reduces their capacity to absorb IL-2 activity from supernatants of mitogen activated chicken lymphocytes.
authors.affiliation: Institute for General and Experimental Pathology, University of Innsbruck, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Schauenstein
authors.forename: G
authors.initials: G
authors.lastname: Krömer
authors.forename: K
authors.initials: K
authors.lastname: Hála
authors.forename: G
authors.initials: G
authors.lastname: Böck
authors.forename: G
authors.initials: G
authors.lastname: Wick
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis*; D002645:Chickens; D007376:Interleukin-2 / Q000494:pharmacology; D008213:Lymphocyte Activation; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7