Effect of carteolol, indenolol and metoprolol on the thyroid hormone of hyperthyroid patients.
Thirty-four hyperthyroid patients were divided into four groups: placebo, carteolol (20 mg/day), indenolol (60 mg/day) and metoprolol (120 mg/day) groups. The heart rate was determined before and two weeks after the treatment with each drug. Serum levels of T4, T3 and rT3 were measured before, and one and two weeks after the treatment. Both indenolol and metoprolol significantly reduced the heart rate (p less than 0.01 and p less than 0.05, respectively), whereas carteolol was ineffective. Carteolol significantly decreased T4 from 23.4 +/- 4.4 micrograms/100 ml to 20.1 +/- 3.2 micrograms/100 ml (p less than 0.01) in one week and to 20.0 +/- 3.7 micrograms/100 ml (p less than 0.01) in two weeks. T3 and rT3 were also decreased significantly (p less than 0.05 and p less than 0.01, respectively) two weeks after the treatment with carteolol. After two weeks of indenolol treatment, T4 was decreased significantly from 26.2 +/- 8.5 micrograms/100 ml to 23.9 +/- 8.2 micrograms/100 ml (p less than 0.05) and T3 from 789 +/- 391 ng/100 ml to 592 +/- 340 ng/100 ml (p less than 0.02). Metoprolol had no effect on serum thyroid hormone levels. The decrease in the serum level of thyroid hormones by carteolol and indenolol but not by metoprolol in patients with hyperthyroidism would be due to the blockade of beta 2-adrenoreceptors concerning with thyroid hormone secretion.
Yamamoto
M
M
Sakurada
T
T
Yoshida
K
K
Kaise
K
K
Kaise
N
N
Fukazawa
H
H
Suzuki
M
M
Nomura
T
T
Itagaki
Y
Y
Saito
S
S
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002354:Carteolol / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000503:physiopathology; D007192:Indenes / Q000494:pharmacology*; D008297:Male; D008790:Metoprolol / Q000494:pharmacology*; D008875:Middle Aged; D011412:Propanolamines / Q000494:pharmacology*; D013963:Thyroid Hormones / Q000097:blood*
D000319:Adrenergic beta-Antagonists; D007192:Indenes; D011412:Propanolamines; D013963:Thyroid Hormones; C002989:indenolol; D002354:Carteolol; D008790:Metoprolol