title: [Decrease in the level and enzymatic activity of cytochrome P-450 during diethylnitrosamine metabolism in vivo and in vitro].
abstract: Diethylnitrosamine (DENA) intoxication of rats was accompanied by a reduction of cytochrome P-450 content in the liver, which correlated well with inactivation of cytochrome P-450 during metabolism of DENA in the liver microsomes.
authors.forename: O F
authors.initials: OF
authors.lastname: Goloshchapov
authors.forename: Ia M
authors.initials: IaM
authors.lastname: Koen
authors.forename: T S
authors.initials: TS
authors.lastname: Shuliakovskaia
authors.forename: L P
authors.initials: LP
authors.lastname: Kaiushin
mesh_terms: D000818:Animals; D001711:Biotransformation; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004052:Diethylnitrosamine / Q000493:pharmacokinetics / Q000633:toxicity*; D004578:Electron Spin Resonance Spectroscopy; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D065607:Cytochrome P-450 Enzyme Inhibitors; D004052:Diethylnitrosamine; D003577:Cytochrome P-450 Enzyme System
vernacular_title: Snizhenie soderzhaniia i fermentativnoĭ aktivnosti tsitokhroma P-450 v khode metabolizma diétilnitrozamina in vivo i in vitro.