title: Renal metastases of gestational trophoblastic disease: a report of eight cases.
abstract: Between 1968-1984, eight women with renal metastases of gestational trophoblastic disease were treated at the Southeastern Regional Trophoblastic Disease Center. Two (1.3%) of 154 patients referred for primary therapy and six (14%) of 42 patients referred for secondary therapy of metastatic gestational trophoblastic disease had renal metastases. All eight had coexistent pulmonary metastases. Four had central nervous system and other systemic metastases. All had high-risk metastatic gestational trophoblastic disease by assessment of individual risk factors and analysis of a prognostic index score. Three women with limited systemic tumor burden are alive after receiving multiagent chemotherapy and nephrectomy.
authors.affiliation: Southeastern Regional Trophoblastic Disease Center, Duke University Medical Center, Durham, North Carolina.
authors.forename: J T
authors.initials: JT
authors.lastname: Soper
authors.forename: D G
authors.initials: DG
authors.lastname: Mutch
authors.forename: N
authors.initials: N
authors.lastname: Chin
authors.forename: D L
authors.initials: DL
authors.lastname: Clarke-Pearson
authors.forename: C B
authors.initials: CB
authors.lastname: Hammond
mesh_terms: D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000556:secondary* / Q000628:therapy; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000556:secondary* / Q000628:therapy; D014594:Uterine Neoplasms