Drug induced red blood cell autoantibodies co-developed with drug specific antibodies causing haemolytic anaemias.
Four individuals with anti-glafenine, anti-latamoxef and anti-teniposide antibodies were found to have an associated red blood cell autoantibody. The two components could be separated by selective absorption and showed distinct time course patterns. In three patients a well-defined blood group antigen was recognized as the receptor for both auto- and drug specific antibodies. Similarities between this type of immune response to drugs and the well-known hapten and carrier specificities developed in animals immunized by hapten-carrier conjugates are discussed.
Habibi
B
B
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced / Q000276:immunology*; D000906:Antibodies / Q000032:analysis; D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis*; D004342:Drug Hypersensitivity / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D005897:Glafenine / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009070:Moxalactam / Q000276:immunology; D013713:Teniposide / Q000276:immunology
D000906:Antibodies; D001323:Autoantibodies; D005897:Glafenine; D013713:Teniposide; D009070:Moxalactam