[Neuromediator mechanisms of the effect of the antihistamine agent dimebone on the brain].
Dimebone was shown to inhibit monoamine oxidase (MAO) deaminating dopamine and serotonin, decrease dopamine metabolism in the basal ganglia of the rat brain, increase noradrenaline level and depress dopamine deamination in the hypothalamus. Dimebone first increased and then diminished the release of dopamine in the cortex, with the concomitant MAO activation and the increase in dopamine and noradrenaline levels. The in vitro experiments have demonstrated that dimebone (10(-4)) preferentially inhibited MAO activity, type B and dopamine deamination in homogenates of different rat brain structures. The role of MAO inhibition in the mechanism of dimebone action on the catecholamine metabolism in the brain structures and its stimulating effect on CNS are discussed.
Shadurskaia
S K
SK
Khomenko
A I
AI
Pereverzev
V A
VA
Balaklevskiĭ
A I
AI
D000818:Animals; D001479:Basal Ganglia / Q000201:enzymology; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008996:Monoamine Oxidase Inhibitors; D009043:Motor Activity / Q000187:drug effects; D051381:Rats
D006634:Histamine H1 Antagonists; D007211:Indoles; D008996:Monoamine Oxidase Inhibitors; C010119:latrepirdine
Neĭromediatornye mekhanizmy deĭstviia antigistaminnogo preparata dimebona na mozg.