A silencer element from the alpha-globin gene inhibits expression of beta-like genes.
We have studied the cis and trans interactions of the alpha- and beta-globin genes in a transient expression system. We found that the alpha-globin gene inhibited beta-globin expression in cis but not in trans. The silencer element responsible for this inhibition was localized to a 259-base-pair fragment at the 5' end of the alpha-globin gene.
Atweh
G F
GF
Department of Medicine, University of Michigan School of Medicine, Ann Arbor.
Liu
J M
JM
Brickner
H E
HE
Zhu
X X
XX
D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D005809:Genes, Regulator; D008040:Genetic Linkage; D005914:Globins / Q000235:genetics*; D006367:HeLa Cells; D006801:Humans; D005810:Multigene Family; D013539:Simian virus 40 / Q000235:genetics
D005914:Globins