Effect of ibopamine on diuresis and arterial blood pressure in anesthetized rats and its interactions with dopaminergic and alpha- and beta-adrenergic antagonists.
The present paper reports a study of the effect of ibopamine (SB-7505), the 3,4-diisobutyryl ester of N-methyldopamine (epinine), on diuresis and blood pressure in anesthetized rats. The results obtained demonstrate that ibopamine, administered orally at doses of 12.5 to 200 mg/kg, caused a dose-dependent diuresis. The increase in blood pressure was moderate and of short duration. The diuretic effect of ibopamine was antagonized by d-sulpiride, haloperidol, bulbocapnine and phenoxybenzamine, but not by l-sulpiride and l-propranolol. The increase in blood pressure was antagonized by phenoxybenzamine only. The diuretic effect of ibopamine in rats reflects agonist activity at dopamine receptors and, in part, alpha-adrenoceptors and is independent of beta-adrenoceptors.
Ferrini
R
R
Miragoli
G
G
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003846:Deoxyepinephrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects*; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004347:Drug Interactions; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D013469:Sulpiride / Q000494:pharmacology; D013997:Time Factors
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D011954:Receptors, Dopamine; D013469:Sulpiride; C023487:ibopamine; D003846:Deoxyepinephrine; D004298:Dopamine