title: Structure of the human blood platelet membrane glycoprotein Ib alpha gene.
abstract: The gene for human platelet glycoprotein Ib alpha-chain has been cloned from a genomic cosmid library using a partial cDNA clone as probe. 3530 bp were sequenced including the entire transcribed part, as well as additional 5' and 3' regions. A single intron was found 6 bp upstream of the ATG initiation codon. An exceptionally long exon was identical to the recently published cDNA sequence (1). The 5' upstream promoter region is atypical for eukaryotic genes with only a weak homology to the characteristic promoter consensus sequences. The 3' region contains two repetitive Alu elements, belonging to distinct subfamilies, connected by an oligo(dA) linker.
authors.affiliation: Theodor Kocher Institute, University of Berne, Switzerland.
authors.forename: R H
authors.initials: RH
authors.lastname: Wenger
authors.forename: N
authors.initials: N
authors.lastname: Kieffer
authors.forename: A N
authors.initials: AN
authors.lastname: Wicki
authors.forename: K J
authors.initials: KJ
authors.lastname: Clemetson
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D003360:Cosmids; D004247:DNA / Q000097:blood / Q000235:genetics; D004262:DNA Restriction Enzymes; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D010980:Platelet Membrane Glycoproteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D010980:Platelet Membrane Glycoproteins; D012333:RNA, Messenger; D004247:DNA; D004262:DNA Restriction Enzymes