[Effect of preparations on the intracellular cAMP and prostaglandin E content and on the functional activity of antigen-induced B-suppressors].
Not adhering to a plastic, B-cells of intact or immunized with the suboptimal dose of ram erythrocytes mice were treated in vitro with several agonists and antagonists of cAMP and prostaglandins E and then were transferred to syngenic or allogenic unirradiated recipients. Afterwards the number of the antibody-forming cells against ram erythrocytes was determined. It was shown that a decrease of cAMP and prostaglandin E contents in the intact B-cells results in the appearance of the ability to stimulate the immune response. An increase of cAMP content in the immune B-cells is followed by a reduction of their suppressing activity. The absence of the relationship between this activity and prostaglandin E content in the immune cells is suggested.
Borisova
L S
LS
Kalinkovich
A G
AG
Inzhevatkina
S M
SM
Zakirov
M M
MM
Gol'dshteĭn
M M
MM
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D001402:B-Lymphocytes / Q000032:analysis / Q000187:drug effects* / Q000276:immunology / Q000637:transplantation; D000242:Cyclic AMP / Q000032:analysis* / Q000037:antagonists & inhibitors; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007114:Immunization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011458:Prostaglandins E / Q000032:analysis* / Q000037:antagonists & inhibitors; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D000941:Antigens; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; D000242:Cyclic AMP
Vliianie nekotorykh preparatov na vnutrikletochnoe soderzhanie tsAMF i prostaglandinov E i funktsional'nuiu aktivnost' antigenindutsirovannykh B-supressorov.