Factors predicting abnormal hysterosalpingographic findings in patients treated for acute pelvic inflammatory disease.
One hundred forty-six consecutive inpatients with acute pelvic inflammatory disease (PID) were randomly treated either with the combination of doxycycline and metronidazole or with the combination of penicillin G/amoxicillin and metronidazole. Forty-three women underwent hysterosalpingography (HSG) 6 months after the treatment, and a multivariate statistical analysis was used to study the effect of 11 different variables (parity, history of previous abortion, history of previous PID, use of an intrauterine contraceptive device (IUD), use of oral contraceptives, presence of adnexal mass, results of cervical cultures for Neisseria gonorrhoeae, and Chlamydia trachomatis, presence of serum antichlamydial antibodies, penicillin-metronidazole treatment, and doxycyclin-metronidazole treatment) on the hysterosalpingographic findings. Abnormal HSG was most likely to occur in women who had antichlamydial antibodies present in the serum, an adnexal mass detected on the initial bimanual examination, or had an IUD (positive associations) and least likely to occur in women who had been treated with the combination of doxycycline and metronidazole (negative association).
Paavonen
J
J
Vesterinen
E
E
Aantaa
K
K
Räsänen
J
J
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage; D002690:Chlamydia Infections / Q000150:complications; D002986:Clinical Trials as Topic; D004318:Doxycycline / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007047:Hysterosalpingography; D007247:Infertility, Female / Q000209:etiology*; D007434:Intrauterine Devices / Q000009:adverse effects; D008795:Metronidazole / Q000008:administration & dosage; D000292:Pelvic Inflammatory Disease / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D010400:Penicillin G / Q000008:administration & dosage; D011247:Pregnancy; D011379:Prognosis; D011897:Random Allocation
D008795:Metronidazole; D000658:Amoxicillin; D004318:Doxycycline; D010400:Penicillin G