Effect of somatostatin on bethanechol-stimulated gastric pepsin secretion in gastric fistula dogs.
The effect of somatostatin on pepsin secretion was determined in six dogs with gastric fistulas during stimulation with bethanechol. Somatostatin inhibited dose-dependently the stimulated pepsin secretion, with a dose of 0.3 micrograms/kg/h being 35% inhibitory during stimulation with bethanechol, 80 micrograms/kg/h. Continuous infusion of somatostatin for 3 h did not cause any signs of tachyphylaxis. Withdrawal of somatostatin produced a return to the control level. The dose-response kinetics with five doses of bethanechol with and without somatostatin showed inhibition of a noncompetitive type. The effects of somatostatin were not altered by using adrenergic, dopaminergic, or serotonergic blocking drugs.
Ladegaard
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L
Bech
K
K
Andersen
D
D
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001626:Bethanechol Compounds / Q000494:pharmacology*; D004285:Dogs; D004294:Domperidone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005769:Gastrointestinal Motility; D007700:Kinetics; D008297:Male; D010434:Pepsin A / Q000378:metabolism*; D011706:Pyloric Antrum / Q000502:physiology*; D012636:Secretory Rate / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology; D013004:Somatostatin / Q000378:metabolism / Q000494:pharmacology*; D013270:Stomach / Q000502:physiology*
D000319:Adrenergic beta-Antagonists; D001626:Bethanechol Compounds; D012702:Serotonin Antagonists; D013004:Somatostatin; D004294:Domperidone; D010434:Pepsin A