title: [Pre- and post-synaptic activity of glutamate on preparations of the frog semicircular canal].
abstract: Glutamate (Glu) has at least two sites of action in the frog semicircular canal: the hair cell (presynaptic) and the primary afferent nerve fibres (postsynaptic). Glu's action on the hair cell results in an increased release of the natural transmitter which is responsible for a substantial increase in the frequency of firing in primary afferents. Glu produces a long-lasting depolarization in the afferent nerve fibres which does not by itself elicit any afferent discharge of impulses when the release of the natural transmitter is prevented. The difficulty of reconciling some of the observations made of the effects of Glu in semicircular canals with its presumed role as an afferent transmitter in this organ is discussed.
authors.forename: P
authors.initials: P
authors.lastname: Valli
authors.forename: I
authors.initials: I
authors.lastname: Prigioni
authors.forename: G
authors.initials: G
authors.lastname: Zucca
authors.forename: L
authors.initials: L
authors.lastname: Botta
authors.forename: P S
authors.initials: PS
authors.lastname: Guth
mesh_terms: D000818:Animals; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D006198:Hair Cells, Auditory / Q000187:drug effects*; D009475:Neurons, Afferent / Q000187:drug effects*; D011893:Rana esculenta; D012665:Semicircular Canals / Q000187:drug effects* / Q000294:innervation
chemical_list: D005971:Glutamates; D018698:Glutamic Acid
vernacular_title: Azione pre e postsinaptica del glutammato sul preparato di canale semicircolare di rana.