Anticonvulsant action of beta-kainic acid in mice. Is beta-kainic acid an N-methyl-D-aspartate antagonist?
An effect of the beta-stereoisomer of kainic acid on seizures produced by intracerebroventricular injections of excitatory amino acids was tested in mice. beta-Kainic acid preferentially antagonizes myoclonic seizures induced by N-methyl-D-aspartate and quinolinate, has less pronounced anticonvulsant action against alpha-kainate, D-homocysteinesulphinate and quisqualate, and no effect on convulsions induced by L-glutamate. The anticonvulsant activity of beta-kainic acid matches that of 2-amino-7-phosphonoheptanoic and kynurenic acids, both preferential N-methyl-D-aspartate receptor antagonists, and differs considerably from the profile of anticonvulsant action of gamma-D-glutamylaminomethylsulphonic acid, a preferential kainate/quisqualate antagonist.
Turski
L
L
Meldrum
B S
BS
Collins
J F
JF
D000818:Animals; D000927:Anticonvulsants; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D018691:Excitatory Amino Acid Antagonists; D018698:Glutamic Acid; D006710:Homocysteine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D007608:Kainic Acid / Q000494:pharmacology*; D051379:Mice; D016202:N-Methylaspartate; D010069:Oxadiazoles / Q000037:antagonists & inhibitors; D011759:Pyrrolidines / Q000494:pharmacology*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000037:antagonists & inhibitors; D016318:Quisqualic Acid; D012640:Seizures / Q000139:chemically induced; D013237:Stereoisomerism
D000927:Anticonvulsants; D018691:Excitatory Amino Acid Antagonists; D010069:Oxadiazoles; D011759:Pyrrolidines; D011805:Quinolinic Acids; D006710:Homocysteine; D001224:Aspartic Acid; C010982:homocysteinesulfinic acid; D018698:Glutamic Acid; D016202:N-Methylaspartate; D016318:Quisqualic Acid; D017378:Quinolinic Acid; D007608:Kainic Acid