title: [Clinical significance of the measurement of serum enzyme activity in children].
abstract: The most frequently estimated enzyme-activities in the serum of children are discussed; these are the serum transaminases GOT and GPT, gamma-GT, alkaline phosphatase, lactate and hydroxy-butyrate dehydrogenase, as well as the creatinkinase and the alpha-amylase. The limited significance of these results for the diagnosis or prognosis is shown. A pattern of several enzyme-activities allows for a better judgement of a situation than the measurement of only one enzyme. Nowadays easier isoenzyme determinations allow for an organ-specific diagnosis. The inherited rise of alkaline phosphatase activity in the absence of disease is known, equally the idiopathic rise of creatinkinase and alpha-amylase. All results of enzyme-activity measurements should be judged in the context if the clinical situation.
authors.forename: F C
authors.initials: FC
authors.lastname: Sitzmann
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood; D004798:Enzymes / Q000097:blood*; D006801:Humans; D006867:Hydrolases / Q000097:blood; D006884:Hydroxybutyrate Dehydrogenase / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D007527:Isoenzymes / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D010084:Oxidation-Reduction; D012016:Reference Values; D000516:alpha-Amylases / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D004798:Enzymes; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D006867:Hydrolases; D000516:alpha-Amylases
vernacular_title: Klinische Bedeutung von Enzymaktivitätsmessungen im Serum bei Kindern.