Distribution and characterization of cyclo(His-Pro)-like immunoreactivity in human cerebrospinal fluid.
The distribution of cyclo(His-Pro), thyrotropin-releasing hormone and pyroglutamate aminopeptidase activity was examined in the CSF of human and a number of other mammalian species. Cyclo(His-Pro)-like immunoreactivity was present in the CSF of all species examined, and was immunologically and chromatographically identical with the authentic cyclo(His-Pro). Cyclo(His-Pro) concentration in CSF had no significant correlation with CSF TRH or pyroglutamate aminopeptidase.
Prasad
C
C
Iriuchijima
T
T
Rao
J K
JK
Wilber
J F
JF
Jayaraman
A
A
D000328:Adult; D000368:Aged; D000818:Animals; D002415:Cats; D002845:Chromatography; D004285:Dogs; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000134:cerebrospinal fluid*; D010879:Piperazines / Q000134:cerebrospinal fluid*; D011751:Pyroglutamyl-Peptidase I / Q000134:cerebrospinal fluid; D011863:Radioimmunoassay; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000134:cerebrospinal fluid
D010456:Peptides, Cyclic; D010879:Piperazines; D013973:Thyrotropin-Releasing Hormone; D011751:Pyroglutamyl-Peptidase I; C015924:histidyl-proline diketopiperazine