[Molecular tools for the study of calcium channels: synthesis and evaluation of biological activity of new derivatives of 4-aryl-1,4-dihydropyridine groups].
The synthesis and biological activity of some novel analogs of the calcium channel blocker nifedipine, i.e., derivatives of 2.6-dimethyl-3.5-diethoxycarbonyl-4-(3-nitrophenyl)-1.4-dihydropyridine (DHP) were studied. One radioactive and two photoactivable DHP derivatives were obtained. DHP hemisuccinate was used to prepare an affinity matrix, DHP-Sepharose as well as a DHP-albumin conjugate; the latter was used for anti-DHP antibodies generation in rabbits. All novel DHP derivatives were obtained from a single key 3-hydroxycarbonyl DHP derivative, and they comprise a series of necessary tools for the study and isolation of membrane calcium channels.
Soldatov
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D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology; D015220:Calcium Channels / Q000032:analysis* / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002846:Chromatography, Affinity; D004095:Dihydropyridines / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D008024:Ligands; D009543:Nifedipine / Q000031:analogs & derivatives / Q000494:pharmacology; D011817:Rabbits; D011978:Receptors, Nicotinic / Q000032:analysis / Q000187:drug effects
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D004095:Dihydropyridines; D008024:Ligands; D011978:Receptors, Nicotinic; D009543:Nifedipine
Molekuliarnye instrumenty izucheniia kal'tsievykh kanalov: sintez i otsenka biologicheskoĭ aktivnosti novykh proizvodnykh gruppy 4-aril-1,4-digidropiridina.