title: Pathophysiological and prognostic significance of cerebrospinal-fluid lactate in cerebral malaria.
abstract: Cerebrospinal-fluid (CSF) lactate concentrations were elevated in all but 1 of 45 patients with cerebral malaria. They were significantly higher in patients who died (9.0 +/- 5.3 mmol/l, mean +/- SD) than in survivors (3.4 +/- 1.1 mmol/l, p = 0.0002) and had returned to normal values in each of 9 patients studied after recovery of consciousness. There was a significant negative correlation between CSF lactate and CSF glucose. All 11 patients with CSF lactate concentrations above 6 mmol/l died. CSF lactate is thus an important prognostic indicator in cerebral malaria and these findings suggest that hypoxia contributes to the pathogenesis of this disorder.
authors.forename: N J
authors.initials: NJ
authors.lastname: White
authors.forename: D A
authors.initials: DA
authors.lastname: Warrell
authors.forename: S
authors.initials: S
authors.lastname: Looareesuwan
authors.forename: P
authors.initials: P
authors.lastname: Chanthavanich
authors.forename: R E
authors.initials: RE
authors.lastname: Phillips
authors.forename: P
authors.initials: P
authors.lastname: Pongpaew
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000378:metabolism; D001927:Brain Diseases / Q000378:metabolism*; D002648:Child; D005260:Female; D005947:Glucose / Q000134:cerebrospinal fluid / Q000378:metabolism; D006801:Humans; D007773:Lactates / Q000134:cerebrospinal fluid* / Q000378:metabolism; D008288:Malaria / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum; D011379:Prognosis
chemical_list: D007773:Lactates; D005947:Glucose