Action and localization of neuropeptide Y in the human fallopian tube.
Using indirect immunohistochemistry, neuropeptide Y-like immunoreactivity was found in nerve fibers around blood vessels and in the muscle layers of the human fallopian tube. Apart from a network of immunoreactive nerve fibers in connection with the luminary epithelium of the isthmus, the distribution resembled that of adrenergic, tyroxine hydroxylase immunoreactive, nerve fibers. Neuropeptide Y was found to have a dose-dependent inhibitory action on the adrenergic contractile response to field stimulation in the external longitudinal muscle layer of the isthmus. Furthermore, neuropeptide Y inhibited [3H]noradrenaline release from isthmic preparations during field stimulation, suggesting a prejunctional inhibitory action on adrenergic neurotransmission.
Samuelson
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Dalsgaard
C J
CJ
D000328:Adult; D005187:Fallopian Tubes / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D009130:Muscle, Smooth / Q000201:enzymology / Q000378:metabolism / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism / Q000502:physiology*; D009478:Neuropeptide Y; D009638:Norepinephrine / Q000378:metabolism; D014018:Tissue Distribution; D014316:Tritium; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D014316:Tritium; D014446:Tyrosine 3-Monooxygenase; D009638:Norepinephrine