title: Influence of ophthalmic formulations on sodium cromoglycate disposition in the albino rabbit eye.
abstract: The effect of different ophthalmic vehicles on the disposition of sodium cromoglycate in tears and ocular tissues of the rabbit eye has been studied over 6 h. The vehicles contained sodium cromoglycate, 2% in an aqueous solution, 2 and 4% in an oleaginous formulation of polyethylene and mineral oil (Plastibase 5W), and 4% in an absorption ointment base of 10% hypoallergenic acetylated lanolin (Modulan) in paraffins. The last formulation was superior to all others studied over 6 h in prolonging the retention of sodium cromoglycate in the precorneal area and the conjunctiva. The concentration of sodium cromoglycate in the tears, conjunctiva and cornea 6 h after administration of the acetylated lanolin base equalled or exceeded the concentrations obtained with the aqueous solution 1 h post-instillation.
authors.forename: R P
authors.initials: RP
authors.lastname: Shrewsbury
authors.forename: J
authors.initials: J
authors.lastname: Swarbrick
authors.forename: K S
authors.initials: KS
authors.lastname: Newton
authors.forename: L C
authors.initials: LC
authors.lastname: Riggs
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D003228:Conjunctiva / Q000378:metabolism; D003315:Cornea / Q000378:metabolism; D004205:Cromolyn Sodium / Q000008:administration & dosage* / Q000378:metabolism; D005123:Eye / Q000378:metabolism*; D008297:Male; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D011817:Rabbits; D013666:Tears / Q000032:analysis; D013997:Time Factors
chemical_list: D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D004205:Cromolyn Sodium