A comparative study of monooxygenase activity in elasmobranchs and mammals: activation of the model pro-carcinogen aflatoxin B1 by liver preparations of calf, nurse shark and clearnose skate.
Liver microsome preparations of the elasmobranchs Ginglymostoma cirratum (nurse shark) and Raja eglanteria (clearnose skate) were examined for monooxygenase activity using aflatoxin B1 as substrate. At equiprotein concentrations, elasmobranch microsomes were less than 20% as active as calf liver in producing mutagenic metabolites of aflatoxin B1.
Bodine
A B
AB
Luer
C A
CA
Gangjee
S
S
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000494:pharmacology*; D002417:Cattle; D005399:Fishes; D006639:Histidine / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009152:Mutagenicity Tests; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects; D012754:Sharks; D013045:Species Specificity
D000348:Aflatoxins; D002273:Carcinogens; D006639:Histidine; D016604:Aflatoxin B1; D006899:Mixed Function Oxygenases