Effect of antibodies against the gap junction protein on differentiation of induced embryonic cells.
Microinjections of antibodies against gap junction protein to early blastomeres of Xenopus laevis were succeeded by the treatments of mesodermal inductor. It was found that induction was not affected by the injection of the antibodies but the differentiation of notochord and muscle was impeded at different degrees. Cell interactions via gap junction communication seem to be involved in the differentiation of the induced cells.
Zeng
M B
MB
Shanghai Institute of Cell Biology, Academia Sinica.
Chen
Y H
YH
D000818:Animals; D000910:Antibodies, Heterophile / Q000502:physiology*; D001757:Blastomeres / Q000166:cytology*; D002454:Cell Differentiation; D017630:Connexins; D004627:Embryonic Induction; D008565:Membrane Proteins / Q000276:immunology*; D014982:Xenopus laevis
D000910:Antibodies, Heterophile; D017630:Connexins; D008565:Membrane Proteins