Evidence that ATP is involved as a co-transmitter in the hypogastric nerve supplying the seminal vesicle of the guinea-pig.
Electrical field stimulation of the guinea-pig seminal vesicle (4 Hz and 16 Hz) produced a biphasic response. The initial rapid twitch response was blocked by desensitisation of the P2-purinoceptor with alpha, beta-methylene ATP. The slower tonic response was blocked by the alpha-adrenoceptor antagonist phentolamine (10 microM). The present results are similar to those found earlier for the guinea-pig vas deferens, indicating that ATP and NA may be released as co-transmitters from hypogastric nerve fibres.
Meldrum
L A
LA
Burnstock
G
G
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D006168:Guinea Pigs; D007001:Hypogastric Plexus / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D018377:Neurotransmitter Agents; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D012669:Seminal Vesicles / Q000294:innervation*; D013779:Tetrodotoxin / Q000494:pharmacology
D018377:Neurotransmitter Agents; D013779:Tetrodotoxin; D000255:Adenosine Triphosphate; C002630:alpha,beta-methyleneadenosine 5'-triphosphate; D009638:Norepinephrine; D010646:Phentolamine