title: Proteases in human lenses and their possible significance.
abstract: Proteases identified as exopeptidases including dipeptidyl II and III, phenylalanine, leucine, methionine, lysine and alanine aminopeptidases, and prolyl endopeptidase were found in extracts of human fetal lenses. Previous data from normal adult lenses were included for comparison. Except for prolyl endopeptidase and dipeptidyl peptidase II, all protease activities were lower in fetal lenses.
authors.forename: A A
authors.initials: AA
authors.lastname: Swanson
authors.forename: R M
authors.initials: RM
authors.lastname: Davis
authors.forename: N C
authors.initials: NC
authors.lastname: Meinhardt
mesh_terms: D000626:Aminopeptidases / Q000378:metabolism; D018826:CD13 Antigens; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D020689:Exopeptidases; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007908:Lens, Crystalline / Q000196:embryology / Q000201:enzymology*; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D008239:Lysine / Q000378:metabolism; D063208:Methionyl Aminopeptidases; D010447:Peptide Hydrolases / Q000378:metabolism*; D010649:Phenylalanine / Q000378:metabolism; D011247:Pregnancy; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases
chemical_list: D010649:Phenylalanine; D010450:Endopeptidases; D020689:Exopeptidases; D010447:Peptide Hydrolases; D000626:Aminopeptidases; D007931:Leucyl Aminopeptidase; D063208:Methionyl Aminopeptidases; D018826:CD13 Antigens; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; C100151:dipeptidyl peptidase II; C100152:dipeptidyl peptidase III; D012697:Serine Endopeptidases; C000705287:PREPL protein, human; D000085822:Prolyl Oligopeptidases; D008239:Lysine