The influence of hGRF, CRF, TRH and LHRH on SRIF release from median eminence fragments.
The influence of 4 releasing factors on the release of somatostatin (SRIF) from the median eminence of the hypothalamus in rats was studied using an in vitro system. Synthetic growth hormone-releasing factor (hGRF-40) and corticotropin releasing factor (CRF) stimulated SRIF release, whereas thyrotrophin-releasing hormone (TRH) and luteinizing hormone releasing hormone (LHRH) did not stimulate its release. CRF and GRF may be physiologically involved in the regulation of SRIF release.
Aguila
M C
MC
McCann
S M
SM
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008473:Median Eminence / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology*; D051381:Rats; D013004:Somatostatin / Q000378:metabolism*
D010446:Peptide Fragments; D010906:Pituitary Hormone-Releasing Hormones; C036893:somatotropin releasing factor 40; D007987:Gonadotropin-Releasing Hormone; D013004:Somatostatin; D003346:Corticotropin-Releasing Hormone; D013007:Growth Hormone-Releasing Hormone