Allogeneic bone marrow transplantation after partial lobectomy for aspergillosis of the lung.
A patient with acute myeloid leukemia (AML) who developed probable aspergillosis of the lung underwent partial lobectomy prior to allogeneic bone marrow transplantation (BMT). Diagnosis was proven by microscopic examination of the resected lung tissue. Local and systemic antifungal prophylaxis with oral amphotericin B plus itraconazole was given throughout the immediate post-transplant period and there was no evidence of recurrent mycosis. Fourteen months after BMT the patient is well, in complete remission and leading a normal life. Pre-transplant pulmonary aspergillosis need not therefore be a contraindication to successful BMT.
Schattenberg
A
A
University Hospital Nijmegen, The Netherlands.
De Vries
F
F
De Witte
T
T
Cohen
O
O
Donnelly
J P
JP
De Pauw
B E
BE
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000601:surgery; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000628:therapy*; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000601:surgery; D011013:Pneumonectomy
D017964:Itraconazole; D000666:Amphotericin B; D007654:Ketoconazole