Zetidoline, a novel neuroleptic, activates nigral dopaminergic neurons in rats.
Zetidoline (ZET), a rather selective dopamine (DA) D2-receptor blocker, was found to be equipotent to haloperidol and over 300 times as potent as sulpiride in activating the firing rate of substantia nigra dopaminergic neurons (SN-DA neurons) in unanesthetized rats. Moreover, like classic and atypical neuroleptics, ZET reversed and prevented apomorphine-induced inhibition of SN-DA neurons.
Mereu
G
G
Fanni
B
B
Collu
M
M
Diena
A
A
Glasser
A
A
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D004594:Electrophysiology; D006220:Haloperidol / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000166:cytology* / Q000187:drug effects; D013469:Sulpiride / Q000494:pharmacology
D014150:Antipsychotic Agents; D007093:Imidazoles; C027277:zetidoline; D013469:Sulpiride; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine