Effect of prostaglandin F2 alpha on brain and stomach 5-hydroxytryptamine.
PGF2 alpha initially inhibits the rate of 5-HT synthesis in both rat brain and stomach and subsequently stimulates it. The results suggest that PGs of E and F series modulate tryptaminergic neuronal activity which in its turn variously affects 5-HT mediated responses.
Sanyal
A K
AK
Chakrabarti
A
A
Goel
R K
RK
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D015237:Dinoprost; D005753:Gastric Mucosa / Q000378:metabolism*; D009020:Morphine / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors; D014191:Tranylcypromine / Q000494:pharmacology
D011460:Prostaglandins F; D012701:Serotonin; D014191:Tranylcypromine; D009020:Morphine; D015237:Dinoprost