Effects of traumatic injury on dynorphin immunoreactivity in spinal cord.
Traumatic spinal cord injury in rats resulted in a significant eleation of dynorphin A immunoreactivity in spinal cord tissue at the level of, and below, the site of injury. [Leu5]enkephalin levels in the same tissue samples were not significantly altered following severe injury. Dynorphin A immunoreactivity was found in the fraction relatively enriched in synaptosomes after subcellular fractionation of spinal cord tissue. The dynorphin A content of this fraction was not significantly changed following injury, suggesting that dynorphin containing nerve terminals and axons are not severely damaged as a result of the injury.
Cox
B M
BM
Molineaux
C J
CJ
Jacobs
T P
TP
Rosenberger
J G
JG
Faden
A I
AI
D000818:Animals; D004399:Dynorphins / Q000032:analysis*; D004743:Enkephalin, Leucine / Q000032:analysis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000032:analysis*; D013119:Spinal Cord Injuries / Q000378:metabolism*; D013347:Subcellular Fractions / Q000032:analysis; D013574:Synaptosomes / Q000032:analysis
D004743:Enkephalin, Leucine; D004399:Dynorphins