Dynorphin levels in parkinsonian patients: Leu5-enkephalin production from either proenkephalin A or prodynorphin in human brain.
When measured in postmortem parkinsonian brains, dynorphin levels were unchanged, as compared to control brains, in mesencephalic, striatal and corticolimbic areas. A significant reduction in Leu5-enkephalin and Met5-enkephalin levels had been previously observed in the pallidum and putamen whereas only Met5-enkephalin concentrations were decreased in the substantia nigra of parkinsonian brains. These data suggest that L-Enk could be generated either from proenkephalin A in the striatal areas or from prodynorphin in the nigral areas.
Taquet
H
H
Javoy-Agid
F
F
Giraud
P
P
Legrand
J C
JC
Agid
Y
Y
Cesselin
F
F
D000368:Aged; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D004399:Dynorphins / Q000378:metabolism*; D004743:Enkephalin, Leucine / Q000096:biosynthesis; D004744:Enkephalin, Methionine / Q000096:biosynthesis; D004745:Enkephalins / Q000096:biosynthesis* / Q000378:metabolism*; D006801:Humans; D010300:Parkinson Disease / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism*
D004745:Enkephalins; D011498:Protein Precursors; C029992:proenkephalin; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D004399:Dynorphins; C033660:preproenkephalin