Influence of ofloxacin and pefloxacin on human lymphocyte immunoglobulin secretion and on polymorphonuclear leucocyte superoxide anion production.
The influence of two fluoroquinolone derivatives, ofloxacin and pefloxacin, on lymphocyte immunoglobulin secretion and on polymorphonuclear leucocyte superoxide anion production was assessed. Pharmacological concentrations did not influence the studied functions, while suprapharmacological concentrations decreased immunoglobulin production.
Fantoni
M
M
Istituto di Clinica delle Malattie Infettive, Università Cattolica del Sacro Cuore, Roma, Italy.
Tamburrini
E
E
Pallavicini
F
F
Antinori
A
A
Nervo
P
P
D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008214:Lymphocytes / Q000276:immunology*; D009504:Neutrophils / Q000378:metabolism*; D015242:Ofloxacin / Q000494:pharmacology*; D015366:Pefloxacin / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism
D007074:Immunoglobulin G; D013481:Superoxides; D015366:Pefloxacin; D015242:Ofloxacin