title: Dopamine receptor stimulation induces a potassium dependent hyperpolarizing response in growth hormone producing neuroendocrine cells of the gastropod mollusc Lymnaea stagnalis.
abstract: Of several putative transmitters used, dopamine was the only one which caused (at low concentrations) a hyperpolarizing response (H-response) in growth hormone producing cells (GHCs) of the freshwater snail Lymnaea stagnalis. Membrane resistance changes, and shifts in the reversal potential of this H-response in different K+-concentrations, indicate that the response is due to an increase in potassium conductance. The dopamine induced H-response is blocked by (-)-sulpiride, 4-aminopyridine, dibutyryl cAMP, 8CPT-cAMP, forskolin and IBMX. These data suggest that dopamine induces the H-response by stimulating a receptor resembling the mammalian D-2 receptor and that this effect of dopamine is mediated by a decrease in the formation of intracellular cAMP.
authors.forename: T A
authors.initials: TA
authors.lastname: de Vlieger
authors.forename: J C
authors.initials: JC
authors.lastname: Lodder
authors.forename: J C
authors.initials: JC
authors.lastname: Stoof
authors.forename: T R
authors.initials: TR
authors.lastname: Werkman
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology; D004702:Endocrine Glands / Q000502:physiology; D013006:Growth Hormone / Q000096:biosynthesis*; D066298:In Vitro Techniques; D007478:Iontophoresis; D008195:Lymnaea / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D009424:Nervous System Physiological Phenomena; D009469:Neuromuscular Junction / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000502:physiology; D011188:Potassium / Q000502:physiology*; D011954:Receptors, Dopamine / Q000187:drug effects*
chemical_list: D001679:Biogenic Amines; D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine; D013006:Growth Hormone; D000262:Adenylyl Cyclases; D011188:Potassium