Localization, analysis and evolution of transposed human immunoglobulin V kappa genes.
The localization of V kappa gene regions to chromosome 2, on which the kappa locus is located, and to other chromosomes is described. The V kappa genes that have been transposed to other chromosomes are called orphons. The finding of two new V kappa genes on chromosome 22 is reported. A V kappa II gene of this region and two V kappa I genes of the Chr1 and the cos 118 regions were sequenced. The two V kappa I orphon sequences and two others that had been determined previously were 97.5% identical, indicating that they may have evolved from a common ancestor by amplification. A model of the evolution of the human V kappa orphons is discussed.
Lötscher
E
E
Institut für Physiologische Chemie, Universität München, F.R.G.
Zimmer
F J
FJ
Klopstock
T
T
Grzeschik
K H
KH
Jaenichen
R
R
Straubinger
B
B
Zachau
H G
HG
D000595:Amino Acid Sequence; D001483:Base Sequence; D005075:Biological Evolution; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D004251:DNA Transposable Elements; D005803:Genes, Immunoglobulin; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D008969:Molecular Sequence Data; D015183:Restriction Mapping
D004251:DNA Transposable Elements; D007135:Immunoglobulin Variable Region; D007145:Immunoglobulin kappa-Chains