title: Haemodynamic stability during anaesthesia induction and sternotomy in patients with ischaemic heart disease. A comparison of six anaesthetic techniques.
abstract: A comparison of haemodynamic stability with respect to arterial pressure, heart rate and cardiac output between six commonly used anaesthetic techniques: fentanyl (FE), halothane (HAL), morphine (MO), fentanyl/droperidol (NLA), and thiopentone (two dose levels: PE 3 and PE 6), all supplemented with nitrous oxide, was performed during induction of anaesthesia and sternotomy in 47 patients with good left ventricular function and maintained beta-blockers undergoing coronary bypass surgery. Interventions were kept to a minimum in order to characterize each anaesthesia group. Statistically, the material fell into two parts. The MO, PE 3 and PE 6 groups showed good stability under steady-state anaesthesia, but variable and often extensive hyperdynamic responses were seen to endotracheal intubation and surgical stimulation. The FE, HAL and NLA groups were characterized by a good stability during the induction-intubation phase but were unstable when combined with nitrous oxide in the absence of noxious stimuli.
authors.forename: I
authors.initials: I
authors.lastname: Milocco
authors.forename: B A
authors.initials: BA
authors.lastname: Löf
authors.forename: G
authors.initials: G
authors.lastname: William-Olsson
authors.forename: L K
authors.initials: LK
authors.lastname: Appelgren
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000768:Anesthesia, General / Q000379:methods*; D000777:Anesthetics / Q000494:pharmacology*; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000503:physiopathology / Q000601:surgery; D004329:Droperidol / Q000494:pharmacology; D005260:Female; D005283:Fentanyl / Q000494:pharmacology; D006221:Halothane / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000494:pharmacology; D009609:Nitrous Oxide / Q000494:pharmacology; D011229:Preanesthetic Medication; D013249:Sternum / Q000601:surgery; D013874:Thiopental / Q000494:pharmacology
chemical_list: D000319:Adrenergic beta-Antagonists; D000777:Anesthetics; D009020:Morphine; D013874:Thiopental; D009609:Nitrous Oxide; D004329:Droperidol; D005283:Fentanyl; D006221:Halothane