Bradykinin and related peptides in central control of the cardiovascular system.
The evidence for a brain kallikrein-kinin system and for the possible role for kinins in brain control of the cardiovascular system are reviewed. All components of the kallikrein-kinin system are present in brain and kinins have a variety of cardiovascular actions of central origin following peripheral, intracerebroventricular or brain parenchymal administration. How components of the brain kallikrein-kinin system are regulated or even whether they function as a system remains to be established. However, bradykinin does fulfill several of the criteria necessary for establishing a substance as a neurotransmitter and these are discussed.
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D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D001931:Brain Mapping; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects; D002415:Cats; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D006651:Histocytochemistry; D007031:Hypothalamus / Q000187:drug effects; D007120:Immunochemistry; D007276:Injections, Intraventricular; D007705:Kinins / Q000494:pharmacology / Q000502:physiology*; D009434:Neural Pathways / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000378:metabolism; D011453:Prostaglandins / Q000502:physiology; D011817:Rabbits; D051381:Rats
D007705:Kinins; D018377:Neurotransmitter Agents; D011453:Prostaglandins; D000242:Cyclic AMP; D006152:Cyclic GMP; D001920:Bradykinin