2-Amino-4-phosphonobutyric acid receptors are not involved in synaptic transmission from hair cells to auditory neurons.
The chemical 2-amino-4-phosphonobutyric acid (APB, AP4), an excitatory amino acid antagonist, was perfused through the guinea-pig cochlea while monitoring various cochlear potentials. The drug (0.6-10 mM) had no effect on the magnitude of the compound action potential of the cochlear nerve, N1 latency, cochlear microphonics, or the summating potential (SP). The results are consistent with the hypothesis that the APB receptor is not involved in neurotransmission between cochlear hair cells and afferent nerve fibers.
Puel
J L
JL
Kresge Hearing Research Laboratory, Department of Otorhinolaryngology and Biocommunication, Louisiana State University Medical Center, New Orleans 70012-2234.
Bobbin
R P
RP
Fallon
M
M
D000200:Action Potentials / Q000187:drug effects; D000613:Aminobutyrates / Q000494:pharmacology; D000818:Animals; D003051:Cochlea / Q000502:physiology*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000502:physiology*; D007656:Ketoglutaric Acids / Q000494:pharmacology; D009412:Nerve Fibers / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*
D000613:Aminobutyrates; D007656:Ketoglutaric Acids; D011956:Receptors, Cell Surface; C012729:2-amino-4-phosphonobutyric acid