Effects of insulin on net hepatic metabolism of acetate and beta-hydroxybutyrate in sheep (Ovis aries).
The net productions of acetate and beta-hydroxybutyrate by the liver and portal-drained viscera were determined before and during insulin plus glucose infusions. Glucose was infused at rates to maintain euglycemia. During insulin infusion the net hepatic productions of beta-hydroxybutyrate and acetate were reduced to a greater extent than could be accounted for by a reduction in provision of free fatty acids to the liver. It is concluded that insulin has a direct anti-ketogenic effect on the ovine liver.
Brockman
R P
RP
Laarveld
B
B
D020155:3-Hydroxybutyric Acid; D000085:Acetates / Q000378:metabolism*; D019342:Acetic Acid; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005934:Glucagon / Q000097:blood; D006885:Hydroxybutyrates / Q000378:metabolism*; D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D012756:Sheep
D000085:Acetates; D001786:Blood Glucose; D006885:Hydroxybutyrates; D007328:Insulin; D005934:Glucagon; D019342:Acetic Acid; D020155:3-Hydroxybutyric Acid