title: Potent and selective activity of a new carbocyclic nucleoside analog (carbovir: NSC 614846) against human immunodeficiency virus in vitro.
abstract: Carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir: NSC 614846), a novel nucleoside analog, emerged as a potent and selective anti-HIV agent from a large screening program conducted by the National Cancer Institute and its contractors. Its hydrolytic stability and its ability to inhibit the infectivity and replication of HIV in T-cells at concentrations of approximately 200- to 400-fold below toxic concentrations make carbovir a top-priority candidate for development as a potential antiretroviral agent in the treatment of AIDS patients.
authors.affiliation: Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455.
authors.forename: R
authors.initials: R
authors.lastname: Vince
authors.forename: M
authors.initials: M
authors.lastname: Hua
authors.forename: J
authors.initials: J
authors.lastname: Brownell
authors.forename: S
authors.initials: S
authors.lastname: Daluge
authors.forename: F C
authors.initials: FC
authors.lastname: Lee
authors.forename: W M
authors.initials: WM
authors.lastname: Shannon
authors.forename: G C
authors.initials: GC
authors.lastname: Lavelle
authors.forename: J
authors.initials: J
authors.lastname: Qualls
authors.forename: O S
authors.initials: OS
authors.lastname: Weislow
authors.forename: R
authors.initials: R
authors.lastname: Kiser
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000998:Antiviral Agents; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D015224:Dideoxynucleosides / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects; D016047:Zalcitabine; D015215:Zidovudine / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D015224:Dideoxynucleosides; C057503:carbovir; D015215:Zidovudine; D016047:Zalcitabine