Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate.
This study presents experimental evidence for the mediation of a behavioral effect of phencyclidine-like drugs by inhibition of neurotransmission at excitatory synapses utilizing N-methyl-aspartate (NMA) receptors by showing that DL-2-amino-5-phosphonovalerate, a selective NMA antagonist, produces phencyclidine-like catalepsy in pigeons. This finding suggests the possibility that other behavioral actions of phencyclidine-like substances may be mediated in a similar fashion.
Koek
W
W
Kleer
E
E
Mudar
P J
PJ
Woods
J H
JH
D015763:2-Amino-5-phosphonovalerate; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced*; D010856:Columbidae; D007276:Injections, Intraventricular; D010622:Phencyclidine / Q000633:toxicity*; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D014633:Valine / Q000031:analogs & derivatives* / Q000633:toxicity
D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D015763:2-Amino-5-phosphonovalerate; D014633:Valine; D010622:Phencyclidine