title: [Hemodynamic effects following bolus administration of different vasopressive agents for blood pressure stabilization during peridural anesthesia].
abstract: Vasopressors are often used to counteract hypotension induced by sympathetic blockade during epidural or spinal anaesthesia. This study contains data of invasive haemodynamic investigations following single-shot applications of different vasoconstrictor agents (Akrinor, etilefrine, ephedrin, norfenefrin, amezinium) during a combination of epidural block and controlled ventilation with oxygen and nitrous oxide. In a preceding dose finding study equipotent dosage of the substances used was confirmed. Usually bolus application of these vasopressors causes only a short-lasting circulatory stimulation, which does not cover the whole period of sympathetic blockade (exception: amezinium). Even small doses of drugs acting only upon alpha-receptors, may cause unwanted peripheral vasoconstriction and decrease of the already lowered cardiac output (example: norfenefrine). The rise of blood pressure after betamimetics may be delayed by an initial vascular beta 2 stimulation (example: etilefrine). In other sympathetic stimulants venoconstriction and therefore improvement of cardiac output by increase of preload takes place after an interval of some minutes to cardiac stimulation (example: ephedrin, Akrinor). Though the use of vasopressor agents during central blockade cannot be recommended in general, substances with alpha- as well as beta-stimulation should be preferred, if necessary. When using substances with short duration of action continuous infusion has to be taken into consideration.
authors.forename: H
authors.initials: H
authors.lastname: Müller
authors.forename: A
authors.initials: A
authors.lastname: Brähler
authors.forename: U
authors.initials: U
authors.lastname: Börner
authors.forename: J
authors.initials: J
authors.lastname: Boldt
authors.forename: M
authors.initials: M
authors.lastname: Stoyanov
authors.forename: G
authors.initials: G
authors.lastname: Hempelmann
mesh_terms: D015078:2-Hydroxyphenethylamine / Q000031:analogs & derivatives / Q000494:pharmacology; D000767:Anesthesia, Epidural; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects; D004809:Ephedrine / Q000494:pharmacology; D005039:Etilefrine / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D009655:Octopamine / Q000031:analogs & derivatives*; D011724:Pyridazines / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology; D013997:Time Factors
chemical_list: D011724:Pyridazines; D013566:Sympathomimetics; D009655:Octopamine; D015078:2-Hydroxyphenethylamine; C005310:norfenefrine; D004809:Ephedrine; C027784:amezinium; D005039:Etilefrine
vernacular_title: Hämodynamische Veränderungen nach der Bolusgabe verschiedener Vasopressiva zur Blutdruckstabilisierung bei Periduralanaesthesie.