title: Effectiveness of bevantolol in the treatment of angina--a placebo-controlled study.
abstract: The antianginal efficacy and safety of bevantolol was compared with placebo in 107 patients with angina pectoris of effort. The median frequency of angina attacks in these patients was 6 per week. Following a 6-week placebo-baseline phase, the patients were randomly assigned to groups receiving either 150 or 300 mg/day bevantolol (75 or 150 mg b.i.d.) or placebo for 6 weeks of double-blind treatment. During exercise tolerance testing at 2 hours postdose, the higher dose of bevantolol produced a marked increase in total work performed. Double product (HR X Systolic BP) at maximum common work load decreased significantly (p less than 0.001) in both bevantolol groups compared with the placebo group. In patients receiving 300 mg/day bevantolol, the proportion who stopped exercising because of angina or S-T depression decreased from 97% to 65%; the frequency of angina attacks decreased by one-half or more in 77% of those with 3 or more attacks per week; and 90% had an improvement in capacity to perform usual daily and occupational activities. A significant therapeutic effect was still present 12 hours postdose. Bevantolol was safe; fewer adverse reactions occurred in either drug group than in the placebo group. Bevantolol appeared to be an effective, well-tolerated drug in the management of angina pectoris.
authors.forename: D J
authors.initials: DJ
authors.lastname: Farnham
mesh_terms: D000203:Activities of Daily Living; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011412:Propanolamines / Q000627:therapeutic use*; D011897:Random Allocation
chemical_list: D000319:Adrenergic beta-Antagonists; D010919:Placebos; D011412:Propanolamines; C021148:bevantolol