Codon usage in Pseudomonas aeruginosa.
We have generated a codon usage table for Pseudomonas aeruginosa. Codon usage in P. aeruginosa is extremely biased. In contrast to E. coli and yeast, P. aeruginosa preferentially uses those codons within a synonymous codon group with the strongest predicted codon-anticodon interaction. We were unable to correlate a particular codon usage pattern with predicted levels of mRNA expressivity. The choice of a third base reflects the high guanine plus cytosine content of the P. aeruginosa genome (67.2%) and cytosine is the preferred nucleotide for the third codon position.
West
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Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, NY 14642.
Iglewski
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BH
D001435:Bacteriophages / Q000235:genetics; D002876:Chromosomes, Bacterial; D003062:Codon; D004251:DNA Transposable Elements; D005786:Gene Expression Regulation; D005796:Genes; D005798:Genes, Bacterial; D010957:Plasmids; D011550:Pseudomonas aeruginosa / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics
D003062:Codon; D004251:DNA Transposable Elements; D012333:RNA, Messenger