title: Independent co-release of acetylcholine and somatostatin from cardiac vagal neurones in toad.
abstract: Vagal postganglionic neurones in toad (Bufo marinus) cause cardio-inhibition by releasing both acetylcholine and somatostatin. In isolated, electrically paced, toad atria, intracardiac neurones were stimulated by short bursts of high-voltage pulses applied during the atrial refractory period. Treatment with hemicholinium-3 (5 X 10(-4) M) for 5 h eliminated most of the acetylcholine-mediated cardio-inhibition but did not inhibit somatostatin-mediated transmission. It is concluded that somatostatin release does not depend on the simultaneous release of acetylcholine.
authors.forename: G
authors.initials: G
authors.lastname: Campbell
authors.forename: F
authors.initials: F
authors.lastname: Jackson
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001338:Autonomic Fibers, Postganglionic / Q000378:metabolism; D002024:Bufo marinus; D006321:Heart / Q000294:innervation*; D006426:Hemicholinium 3 / Q000494:pharmacology; D066298:In Vitro Techniques; D009433:Neural Inhibition; D013004:Somatostatin / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects; D014630:Vagus Nerve / Q000378:metabolism* / Q000502:physiology
chemical_list: D006426:Hemicholinium 3; D013004:Somatostatin; D000109:Acetylcholine