title: Factors associated with progression of cervical human papillomavirus (HPV) infections into carcinoma in situ during a long-term prospective follow-up.
abstract: In the course of a prospective study of 508 women with papillomavirus (HPV) lesions of the uterine cervix, 66 lesions that progressed into carcinoma in situ (CIS) were identified and treated by conization during a mean follow-up period of 35 months. The lesions were investigated with light microscopy and with in-situ DNA hybridization using 35S-labelled probes for HPV 6, 11, 16, 18, 31 and 33. After radical cone treatment, 11 of the 66 women (16.7%) have presented with a recurrent HPV infection. The recurrence rate increased with the duration of the follow-up period from less than 10% at the mean follow-up of 25 months to 16.7% at the most recent follow-up at 35 months. Most of these 66 HPV lesions (89%) presented with concomitant CIN in the first punch biopsy, but it is noteworthy that the other 11% presented without concomitant CIN. HPV DNA of at least one of the six types examined was found in 73% of the first biopsies and it is noteworthy that the so-called 'low-risk' types, HPV 6 and 11, were found as frequently as the 'high-risk' types, HPV 16 and 18 (18% and 17%, respectively). This would suggest a similarity in the biological behaviour of these two HPV groups. Although the concept of the 'high-risk' and 'low-risk' HPV types may remain at least partially valid, it is imperative to realize that infection by HPV 6 and 11 by no means excludes the possibility for clinical progression into CIS and eventually to an invasive carcinoma.
authors.affiliation: Laboratory of Pathology, Finnish Cancer Society, Kuopio.
authors.forename: K
authors.initials: K
authors.lastname: Syrjänen
authors.forename: R
authors.initials: R
authors.lastname: Mäntyjärvi
authors.forename: S
authors.initials: S
authors.lastname: Saarikoski
authors.forename: M
authors.initials: M
authors.lastname: Väyrynen
authors.forename: S
authors.initials: S
authors.lastname: Syrjänen
authors.forename: S
authors.initials: S
authors.lastname: Parkkinen
authors.forename: M
authors.initials: M
authors.lastname: Yliskoski
authors.forename: J
authors.initials: J
authors.lastname: Saastamoinen
authors.forename: O
authors.initials: O
authors.lastname: Castren
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae; D011446:Prospective Studies; D014412:Tumor Virus Infections / Q000150:complications*; D002583:Uterine Cervical Neoplasms / Q000209:etiology*