Comparative in-vitro activity of Sch 34343 and other antimicrobial agents against anaerobic bacteria.
The activity of Sch 34343 was determined against 575 strains of anaerobic bacteria by an agar-dilution method. Its activity was compared with that of benzylpenicillin, piperacillin, cefoxitin, imipenem, clindamycin, metronidazole, chloramphenicol, vancomycin, fusidic acid and bacitracin. Sch 34343 and imipenem were the most active agents tested. Based on these results, Sch 34343 appears to be a promising antimicrobial agent for anaerobic infections and warrants further clinical investigations.
Nord
C E
CE
Olsson-Liljequist
B
B
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001441:Bacteroides fragilis / Q000187:drug effects; D003016:Clostridium perfringens / Q000187:drug effects; D004352:Drug Resistance, Microbial; D005673:Fusobacterium / Q000187:drug effects; D006801:Humans; D007769:Lactams; D008826:Microbial Sensitivity Tests; D010460:Peptococcus / Q000187:drug effects; D010462:Peptostreptococcus / Q000187:drug effects; D011425:Propionibacterium acnes / Q000187:drug effects
D000900:Anti-Bacterial Agents; D007769:Lactams; C044617:Sch 34343