[Effect of phenazepam on the peripheral catecholaminergic systems in immobilization stress].
Fluorescent microscopy and spectrofluorometry of biogenic amines were used to study adrenergic innervation of the dura mater, vas deferens and medullary substance of the adrenals in immobilized rats treated with phenazepam. It was established that phenazepam (1 mg/kg, i. p.) prevented the decrease in the level of the adrenergic transmitter at the stage of anxiety and promoted its stabilization throughout the entire period of body adaptation to immobilization. The stress-protective effect of the drug appeared reduced at the stage of cachexia.
Malikova
L A
LA
Khaĭsman
E B
EB
Arefolov
V A
VA
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine / Q000502:physiology*; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects* / Q000502:physiology; D017983:Receptors, Catecholamine; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology / Q000517:prevention & control*; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine; D001569:Benzodiazepines; C017928:phenazepam; D009638:Norepinephrine; D004837:Epinephrine
Vliianie fenazepama na perifericheskie katekholaminergicheskie sistemy v usloviiakh immobilizatsionnogo stressa.