title: Maturation of steroidogenic cells: a target for IGF-I.
abstract: Using primary culture of steroidogenic cells in vitro, in serum-free chemically defined medium, strong evidence has been provided for actions of IGF-I on the differentiation of immature Leydig cells and on the maintenance of a differentiated function of mature adrenocortical cells. These data point to the steroidogenic cells as a target for IGF-I action. They also add further evidence for a role of IGF-I in the differentiation process. These actions can be of importance in normal physiological situations as well as in abnormal conditions where IGF-I is decreased, such as hypopituitarism and malnutrition.
authors.affiliation: INSERM U307, Hôpital Debrousse, Lyons, France.
authors.forename: P
authors.initials: P
authors.lastname: Chatelain
authors.forename: A
authors.initials: A
authors.lastname: Penhoat
authors.forename: M H
authors.initials: MH
authors.lastname: Perrard-Sapori
authors.forename: C
authors.initials: C
authors.lastname: Jaillard
authors.forename: D
authors.initials: D
authors.lastname: Naville
authors.forename: J
authors.initials: J
authors.lastname: Saez
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D003345:Corticosterone / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D007985:Leydig Cells / Q000187:drug effects*; D008297:Male; D011284:Pregnenolone / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D011974:Receptors, LH / Q000032:analysis; D017451:Receptors, Somatomedin; D013002:Somatomedins / Q000494:pharmacology*
chemical_list: D007328:Insulin; D011956:Receptors, Cell Surface; D011974:Receptors, LH; D017451:Receptors, Somatomedin; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D011284:Pregnenolone; D000242:Cyclic AMP; D003345:Corticosterone