Parkinsonism, tardive dyskinesia, akathisia, and depression induced by flunarizine.
12 subjects, 8 women and 4 men, presented with extrapyramidal motor signs and psychic depression after treatment with flunarizine for between 3 weeks and 15 months. One woman presented with severe symptoms and 20 months after stopping flunarizine she still had dyskinesia and akathisia. The other patients showed partial or complete improvement after withdrawal of the drug.
Chouza
C
C
Scaramelli
A
A
Caamaño
J L
JL
De Medina
O
O
Aljanati
R
R
Romero
S
S
D000368:Aged; D017109:Akathisia, Drug-Induced; D002936:Cinnarizine / Q000009:adverse effects / Q000031:analogs & derivatives*; D003866:Depressive Disorder / Q000139:chemically induced; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D005260:Female; D005444:Flunarizine; D006801:Humans; D008297:Male; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D011605:Psychoses, Substance-Induced / Q000209:etiology
D002936:Cinnarizine; D005444:Flunarizine