[Neuroendocrine larynx cancer of the small cell (oat cell) type. Morphologic and immunohistochemical findings and their significance for therapy].
By combining immunohistochemical, biochemical, and light and electron microscopy techniques, the following original observations concerning the rare and highly malignant small cell ("oat cell") carcinoma of the larynx were made: The typical electron microscopic feature was the presence of neurosecretory granules in some cells. This indicates that this tumour was a carcinoma with endocrinal differentiation. The demonstration of cytokeratins as major cytoskeletal components, as well as the presence of desmosomes, confirmed the epithelial origin of the tumour cells. The detection of neuroendocrinal markers such as calcitonin and neuronspecific enolase (NSE) in some of the tumour cells, as well as the presence of neurosecretory granules allow us to classify this tumour as a neuroendocrinal carcinoma of the small-cell type. This is in accordance with the latest classification of neuroendocrine carcinomas of the lung. The rapid clinical evolution of the disease is typical for patients with anaplastic carcinomas. Laryngectomy followed by adjuvant chemotherapy and radiotherapy is indicated only in cases without metastases. The detection of regional metastases suggests haematogenous spread with distinct metastases, restricting treatment to chemotherapy and radiotherapy.
Weidauer
H
H
Blobel
G A
GA
Nemetschek-Gansler
H
H
Gould
V E
VE
Mall
G
G
D001078:APUD Cells / Q000648:ultrastructure; D000328:Adult; D018288:Carcinoma, Small Cell / Q000201:enzymology / Q000473:pathology*; D006729:Hormones, Ectopic / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D007822:Laryngeal Neoplasms / Q000201:enzymology / Q000473:pathology*; D007830:Larynx / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008854:Microscopy, Electron; D009489:Neurosecretion; D010751:Phosphopyruvate Hydratase / Q000378:metabolism
D006729:Hormones, Ectopic; D010751:Phosphopyruvate Hydratase
Das neuro-endokrine Larynxkarzinom vom kleinzelligen (Oat-Cell) Typ. Morphologische und immunhistochemische Befunde und ihre Bedeutung für Therapie.