A comparison of the pharmacokinetics of atenolol, metoprolol, oxprenolol and propranolol in elderly hypertensive and young healthy subjects.
Six elderly patients with established hypertension and six young healthy subjects were studied after 8 days of treatment with atenolol 50 mg day-1, metoprolol 50 mg day-1, oxprenolol 80 mg day-1 and propranolol 80 mg day-1. The area under the blood concentration-time curve was increased in the elderly group for each drug, but the difference was statistically significant only for atenolol. The lower serum albumin concentrations in the elderly group did not result in a decrease in the percentage of propranolol or oxprenolol bound to serum proteins.
Rigby
J W
JW
Scott
A K
AK
Hawksworth
G M
GM
Petrie
J C
JC
D000319:Adrenergic beta-Antagonists / Q000378:metabolism*; D000328:Adult; D000367:Age Factors; D000368:Aged; D001262:Atenolol / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D006207:Half-Life; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008790:Metoprolol / Q000378:metabolism; D010096:Oxprenolol / Q000378:metabolism; D011433:Propranolol / Q000378:metabolism; D011485:Protein Binding
D000319:Adrenergic beta-Antagonists; D001798:Blood Proteins; D001262:Atenolol; D010096:Oxprenolol; D011433:Propranolol; D008790:Metoprolol