The regulation of noradrenaline synthesis in central nerve terminals by autoreceptors and heteroreceptors in rat.
The effects of alpha 2-adrenoceptor and gamma-aminobutyric acidB (GABAB) receptor activation on noradrenaline synthesis were measured in rat hippocampal synaptosomes. The results show that alpha 2-autoreceptors and GABAB heteroreceptors inhibit K+-accelerated synthesis; they have no effect on basal synthesis.
Birch
P J
PJ
Fillenz
M
M
D015762:2-Chloroadenosine; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D004789:Enzyme Activation; D006624:Hippocampus / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000096:biosynthesis*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D011963:Receptors, GABA-A / Q000502:physiology*; D013574:Synaptosomes / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D011942:Receptors, Adrenergic, alpha; D011963:Receptors, GABA-A; D015762:2-Chloroadenosine; D014446:Tyrosine 3-Monooxygenase; D000241:Adenosine; D003000:Clonidine; D011188:Potassium; D009638:Norepinephrine