Effects of phenobarbitone and 6-methylprednisolone pretreatment on pressure/flow relations in the superior mesenteric and iliac arterial beds of the rat.
The in-situ blood perfused rat superior mesenteric arterial and right iliac arterial preparations were used to investigate the effects of pretreatment for 5 days with either phenobarbitone (80 mg kg-1 daily) or 6-methylprednisolone (17 mg kg-1 daily) on regional vascular resistances. The elevation of the regression of perfusion pressure on perfusion rate in the superior mesenteric arterial bed was significantly decreased by both phenobarbitone and 6-methylprednisolone over the range of flow rates used. Neither phenobarbitone nor 6-methylprednisolone had a significant effect on hepatic portal venous pressure nor was there any significant effect on the regression of perfusion pressure on flow rate in the in-situ iliac arterial bed. It is concluded that pretreatment with either phenobarbitone or 6-methylprednisolone lowers vascular resistance in the superior mesenteric arterial by approximately 9 and 8% respectively but does not affect vascular resistance in the iliac arterial bed.
Hiley
C R
CR
Nichols
A J
AJ
Wilson
A C
AC
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D007083:Iliac Artery / Q000502:physiology; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects; D008102:Liver Circulation / Q000187:drug effects; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010477:Perfusion; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects*; D013152:Splanchnic Circulation / Q000187:drug effects
D008775:Methylprednisolone; D010634:Phenobarbital