[The role of adenine nucleotide translocator in the regulation of oxidative phosphorylation in heart mitochondria].
The regulatory role of adenine nucleotide translocase in oxidative phosphorylation was determined by titration of respiration of isolated rabbit heart mitochondria with carboxyatractyloside in the creatine phosphokinase ADP-regenerating system, which is not rate-limiting. It was found that the respiration rate is not controlled by adenine nucleotide translocase in states 3 and 4. Within the physiological region of respiration (30-70% of the maximal rate), the control coefficient for ADP/ATP translocase is 0.62-0.75. Thus, translocase plays a key role in the regulation of oxidative phosphorylation.
Kholodenko
B N
BN
Zhilinskene
V Iu
VIu
Borutaĭte
V I
VI
Ivanovene
L I
LI
Toleĭkis
A I
AI
D000818:Animals; D007700:Kinetics; D008929:Mitochondria, Heart / Q000201:enzymology / Q000378:metabolism*; D000226:Mitochondrial ADP, ATP Translocases / Q000378:metabolism*; D009713:Nucleotidyltransferases / Q000378:metabolism*; D010084:Oxidation-Reduction; D010085:Oxidative Phosphorylation; D010725:Phosphocreatine / Q000378:metabolism; D011817:Rabbits; D013386:Succinates / Q000378:metabolism
D013386:Succinates; D010725:Phosphocreatine; D000226:Mitochondrial ADP, ATP Translocases; D009713:Nucleotidyltransferases
Rol' perenoschika adeninnukleotidov v reguliatsii okislitel'nogo fosforilirovaniia v mitokhondriiakh serdtsa.