Neural and molecular mechanisms in anxiety.
The recent discoveries of the benzodiazepine receptor and of antagonist compounds, such as beta-CCE, have advanced our understanding of the neurochemistry of anxiety. In this review we summarize the evidence implicating the benzodiazepine receptor in anxiety and relate this model to other models of anxiety.
Wolkowitz
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OM
Paul
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SM
D000241:Adenosine / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D001569:Benzodiazepines; D001667:Binding, Competitive; D002243:Carbolines / Q000378:metabolism / Q000494:pharmacology; D003000:Clonidine / Q000378:metabolism / Q000494:pharmacology; D004195:Disease Models, Animal; D005544:Forecasting; D000882:Haplorhini; D006801:Humans; D008125:Locus Coeruleus / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D010883:Piperoxan / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D011983:Receptors, Purinergic; D012107:Research Design; D015016:Yohimbine / Q000378:metabolism / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D002243:Carbolines; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D011983:Receptors, Purinergic; D001569:Benzodiazepines; D015016:Yohimbine; C024915:beta-carboline-3-carboxylic acid ethyl ester; D010883:Piperoxan; D000241:Adenosine; D003000:Clonidine