A structure-activity relationship study on papaverine analogs.
The structure-activity relationship of papaverine analogs, the inhibitors of adenosine cyclic 3', 5'-monophosphate (c-AMP) phosphodiesterase, is discussed. The enzyme inhibition activity of these compounds are found to be dominantly controlled by hydrophobicity and steric factors. A significant quantitative correlation has been obtained between the inhibition activity and the van der Waals volume.
Gupta
S P
SP
Department of Chemistry, Birla Institute of Technology and Science, India.
Garg
C
C
Gupta
J K
JK
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D010208:Papaverine / Q000031:analogs & derivatives*; D013329:Structure-Activity Relationship
D010208:Papaverine; D015105:3',5'-Cyclic-AMP Phosphodiesterases