Possible interactions between dynorphin and dopaminergic systems in rat basal ganglia and substantia nigra.
Chronic haloperidol treatment markedly increases dynorphin-related peptide contents in caudate-putamen, globus pallidus and substantia nigra. Leu-enkephalin levels follow dynorphin-related peptide concentrations in these areas while Met-enkephalin-related peptide contents are unchanged in the substantia nigra following a similar treatment. An acute haloperidol injection had no effect on any opioid peptide levels in the basal ganglia. This suggests that Leu-enkephalin is likely to be derived from prodynorphin in the rat striatonigral pathway. Moreover, the Leu-enkephalin/dynorphin projection appears to be under striatal dopaminergic control.
Quirion
R
R
Gaudreau
P
P
Martel
J C
JC
St-Pierre
S
S
Zamir
N
N
D000818:Animals; D002421:Caudate Nucleus / Q000032:analysis; D003342:Corpus Striatum / Q000032:analysis* / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D004399:Dynorphins / Q000031:analogs & derivatives* / Q000032:analysis / Q000502:physiology; D004723:Endorphins / Q000032:analysis*; D004743:Enkephalin, Leucine / Q000032:analysis*; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives* / Q000032:analysis; D005917:Globus Pallidus / Q000032:analysis; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D011699:Putamen / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000032:analysis*
D004723:Endorphins; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D004399:Dynorphins; C033453:enkephalin-Met, Arg(6)-Gly(7)-Leu(8)-; C036200:rimorphin; D006220:Haloperidol; D004298:Dopamine