Neurogenic urethra: clinical relevance of isolated neuropathic dysfunction of the urethra, and the denervation supersensitivity of the urethra revisited.
Our clinical experience on isolated neuropathic dysfunction of the urethra is presented. By discussing the urodynamic findings in neurogenic urethra, wherein the denervation supersensitivity to alpha-adrenergic stimulation in the absence of vesical denervation was a common denominator, some insight into the modern concept of motor innervation of the urethra was attempted. Our data are supportive of the current dogma implicating a significant sympathetic contribution to both autonomic and somatomotor innervation of the urethra.
Koyanagi
T
T
Department of Urology, Hokkaido University School of Medicine, Japan.
Morita
H
H
Taniguchi
K
K
Kubota
M
M
Shinno
Y
Y
Takamatsu
T
T
D000328:Adult; D000368:Aged; D003714:Denervation; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D014521:Urethra / Q000294:innervation*; D014522:Urethral Diseases / Q000503:physiopathology*; D001750:Urinary Bladder, Neurogenic / Q000503:physiopathology; D014554:Urination; D014563:Urodynamics
D011942:Receptors, Adrenergic, alpha