[Non-classic effects of luliberin confirming the pleiotropy of neuropeptides].
The effects of synthetic neuropeptide LH-RH and its analogues were studied in experiments on 174 white male rats. The influence of the substances was shown on instrumental avoidance learning in Y-shaped maze. Convulsive and anticonvulsive effects of the preparations were studied on experimental model of corasol seizures. The analgetic effect of the substances was evaluated by behavioural pain reaction to electrical stimulation of the tail root. Analgetic, anticonvulsive, and psychostimulating LH-RH properties confirm polyfunctionality and "pleiotropy" of neuropeptides as a class of new endogenous informational compounds.
Bakharev
V D
VD
Esipov
A S
AS
Burov
S V
SV
Papsuevich
O S
OS
Chipens
G I
GI
D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants; D001362:Avoidance Learning / Q000187:drug effects; D000697:Central Nervous System Stimulants; D003216:Conditioning, Operant / Q000187:drug effects; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D051381:Rats
D000700:Analgesics; D000927:Anticonvulsants; D000697:Central Nervous System Stimulants; D007987:Gonadotropin-Releasing Hormone; D010433:Pentylenetetrazole
"Neklassicheskie" éffekty liuliberina, podtverzhdaiushchie mnogoadresnost' neĭropeptidov.