title: The interaction of cimetidine with various antihypertensive agents in the spontaneously hypertensive rat.
abstract: The H2-receptor antagonist cimetidine (250 micrograms) administered intracerebroventricularly (i.c.v.) 15 and 30 min before clonidine (25 micrograms kg-1 i.v.), significantly antagonized clonidine-induced hypotension in anaesthetized spontaneously hypertensive rats. The hypertensive response of cimetidine was correlated with the inhibition of clonidine-induced hypotension. In addition, cimetidine (250 micrograms i.c.v.) counteracted the hypotensive effects of pentolinium (5.0 mg kg-1 i.v.), guanethidine (5.0 mg kg-1 i.v.) and minoxidil (1.0 mg kg-1 i.v.) These data do not support previous suggestions that the hypotensive action of clonidine is caused by stimulation of the H2-receptor, but suggest that central administration of cimetidine causes peripheral vasoconstriction and this may offer resistance to the hypotensive action of different antihypertensive agents.
authors.forename: N K
authors.initials: NK
authors.lastname: Dadkar
authors.forename: V A
authors.initials: VA
authors.lastname: Aroskar
authors.forename: R D
authors.initials: RD
authors.lastname: Gupte
authors.forename: A N
authors.initials: AN
authors.lastname: Dohadwalla
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002927:Cimetidine / Q000494:pharmacology*; D003000:Clonidine / Q000037:antagonists & inhibitors; D006145:Guanethidine / Q000037:antagonists & inhibitors; D007276:Injections, Intraventricular; D008297:Male; D008914:Minoxidil / Q000037:antagonists & inhibitors; D010425:Pentolinium Tartrate / Q000037:antagonists & inhibitors; D051381:Rats; D011918:Rats, Inbred SHR; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D008914:Minoxidil; D002927:Cimetidine; D010425:Pentolinium Tartrate; D003000:Clonidine; D006145:Guanethidine