[Greater oral activity of etilefrine pivalate compared to etilefrine in the cat and dog].
Etilefrine pivalate (K 30 052, Ep) and etilefrine (E) were compared in regard to their effects on the circulation of cats and dogs and in regard to their effects on isolated organs (papillary muscles, atria, vena cava caudalis) of guinea pigs and rabbits. The effects of Ep and E were qualitatively equal. Ep was less effective than E on isolated organs and after intravenous injection, it was however more effective after oral or intraduodenal application. This result is in line with the hypothesis that Ep is inactivated during the first-pass to a smaller extent than E and is split after absorption to E and pivalinic acid.
Eisenburger
R
R
Seibel
K
K
Hampel
H
H
D000818:Animals; D002415:Cats; D002682:Chinchilla; D004285:Dogs; D005039:Etilefrine / Q000031:analogs & derivatives / Q000494:pharmacology*; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D010210:Papillary Muscles / Q000187:drug effects; D010656:Phenylephrine / Q000031:analogs & derivatives*; D010991:Plethysmography; D011817:Rabbits; D013045:Species Specificity; D013997:Time Factors
D010656:Phenylephrine; C046842:etilefrine pivalate; D005039:Etilefrine
Höhere orale Wirksamkeit von Etilefrinpivalat im Vergleich zu Etilefrin bei Katze und Hund.