Trimethoprim-polymyxin B sulphate ophthalmic ointment in the treatment of bacterial conjunctivitis: a double-blind study versus chloramphenicol ophthalmic ointment.
Forty-two patients with a clinical diagnosis of bacterial conjunctivitis were enrolled in a randomized, double-blind trial. Patients were treated with either trimethoprim-polymyxin B sulphate or chloramphenicol ophthalmic ointments 4-times a day for 7 days. Analysis of clinical evaluation data showed that both treatments were effective and well tolerated, and that there were no statistically significant differences between them with regard to eradication of organisms or clinical improvement.
Behrens-Baumann
W
W
Augenklinik and Poliklinik, Georg-August-Universität, Göttingen, West Germany.
Quentin
C D
CD
Gibson
J R
JR
Calthrop
J G
JG
Harvey
S G
SG
Booth
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002701:Chloramphenicol / Q000008:administration & dosage / Q000627:therapeutic use*; D003234:Conjunctivitis, Bacterial / Q000188:drug therapy*; D004311:Double-Blind Method; D004338:Drug Combinations / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D009824:Ointments; D011112:Polymyxin B / Q000008:administration & dosage / Q000627:therapeutic use*; D011113:Polymyxins / Q000627:therapeutic use*; D011897:Random Allocation; D014295:Trimethoprim / Q000008:administration & dosage / Q000627:therapeutic use*
D004338:Drug Combinations; D009824:Ointments; D011113:Polymyxins; C056487:Polytrim eyedrops; D002701:Chloramphenicol; D014295:Trimethoprim; D011112:Polymyxin B