Renal effects of SK&F 82526 in anesthetized rats.
Dopamine affects renal hemodynamics, renal tubular functions, and the secretion of renin. We have studied the renal effects of SK&F 82526 (an agonist which is selective for the DA1 subclass of dopamine receptors) in anesthetized rats. Infused intravenously at 0.005 mumol/min/kg, this drug increased renal plasma flow and the clearances of PAH and insulin, effects which are consistent with decreased renovascular resistance. Concomitantly, urine flow and K excretion increased, and Na excretion tended to increase. All these effects of SK&F 82526 were antagonized by intravenous metoclopramide (1 mumol/min/kg). Despite its diuretic effect and despite its lack of effect on arterial blood pressure, SK&F 82526 increased arterial plasma renin concentration, suggesting a stimulatory effect on renin secretory rate. Taken together, our results demonstrate that the renal effects of SK&F 82526 mimic those of dopamine.
Bhat
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Churchill
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Churchill
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McDonald
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D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D004347:Drug Interactions; D018818:Fenoldopam; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D007684:Kidney Tubules / Q000502:physiology; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D011188:Potassium / Q000097:blood / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation / Q000187:drug effects*; D012083:Renin / Q000097:blood / Q000378:metabolism; D012964:Sodium / Q000097:blood / Q000652:urine; D014665:Vasodilator Agents / Q000494:pharmacology*
D001552:Benzazepines; D014665:Vasodilator Agents; D012964:Sodium; D012083:Renin; D018818:Fenoldopam; D008787:Metoclopramide; D011188:Potassium