title: Characterization of porphyrin interactions with peripheral type benzodiazepine receptors.
abstract: We have examined organ and species variations in interactions of porphyrins with peripheral-type benzodiazepine receptors and explored structure-activity requirements for porphyrin-receptor interactions. Whereas potency of the benzodiazepine RO5-4864 varies several orders of magnitude in competing for receptors in different organs and species, effects of porphyrins and the isoquinoline carboxamide PK11195 are relatively constant. The structural requirements determining porphyrin affinity for benzodiazepine binding sites are fairly strict. The most potent porphyrins are those with prominent physiological functions.
authors.affiliation: Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
authors.forename: A
authors.initials: A
authors.lastname: Verma
authors.forename: S H
authors.initials: SH
authors.lastname: Snyder
mesh_terms: D000818:Animals; D001570:Benzodiazepinones / Q000378:metabolism; D001667:Binding, Competitive; D002417:Cattle; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D011166:Porphyrins / Q000378:metabolism*; D011817:Rabbits; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D001570:Benzodiazepinones; D007546:Isoquinolines; D011166:Porphyrins; D011963:Receptors, GABA-A; C028513:4'-chlorodiazepam; C037850:PK 11195