title: Tomographic studies of rCBF with [99mTc]-HM-PAO SPECT in patients with brain tumors: comparison with C15O2 continuous inhalation technique and PET.
abstract: In 10 patients with malignant gliomas, the intracerebral distribution of [99mTc]-hexamethylpropylene-amine oxime [( 99mTc]-HM-PAO) was studied with single photon emission computed tomography (SPECT) in comparison with C15O2 steady-state inhalation technique to measure cerebral blood flow using positron emission tomography (PET). In all instances, the cerebral [99mTc]-HM-PAO distribution was comparable with the regional pattern of cerebral blood flow (rCBF) observed with PET. This was confirmed by a significant correlation of tumor to cortex and tumor to white matter ratios between these two experimental methods. However, the contrast between high and low activity regions in the SPECT scans was significantly less than that in the PET scans. Contrast enhancement of the SPECT scans was accomplished using a correction formula proposed by Lassen.
authors.affiliation: Institute of Medicine, Nuclear Research Center Jülich, F.R.G.
authors.forename: K J
authors.initials: KJ
authors.lastname: Langen
authors.forename: H
authors.initials: H
authors.lastname: Herzog
authors.forename: T
authors.initials: T
authors.lastname: Kuwert
authors.forename: N
authors.initials: N
authors.lastname: Roosen
authors.forename: E
authors.initials: E
authors.lastname: Rota
authors.forename: J C
authors.initials: JC
authors.lastname: Kiwit
authors.forename: W J
authors.initials: WJ
authors.lastname: Bock
authors.forename: L E
authors.initials: LE
authors.lastname: Feinendegen
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002245:Carbon Dioxide; D002560:Cerebrovascular Circulation; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D009942:Organometallic Compounds; D010091:Oximes; D010104:Oxygen Radioisotopes; D013667:Technetium; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed
chemical_list: D009942:Organometallic Compounds; D010091:Oximes; D010104:Oxygen Radioisotopes; D002245:Carbon Dioxide; D019690:Technetium Tc 99m Exametazime; D013667:Technetium