Oxidation of lipids. XV. Role of hydrophilic diarylamines as antioxidants in the oxidations of lipids and biological tissues.
The abilities of two kinds of water-soluble diarylamines, disodium 4-chloro-2,2'-iminodibenzoate (CCA) and disodium 4-chloro-3',6'-dimethyl-2,2'-iminodibenzoate (CCM), to protect lipids, membranes and biological tissues from oxidative damages have been studied. The experimental systems studied include the oxidations of methyl linoleate micelles and soybean phosphatidylcholine (Pc) liposomal membranes in aqueous dispersions, oxidative hemolysis of rabbit erythrocytes, and the in vivo oxidative damages of biological tissues all induced by free radicals generated from an azo radical initiator. The two diarylamines functioned as moderate chain-breaking antioxidants and retarded the above oxidations.
Niki
E
E
Department of Reaction Chemistry, Faculty of Engineering, University of Tokyo, Japan.
Takahashi
M
M
Tsuchiya
J
J
Komuro
E
E
Ito
E
E
Terao
K
K
D000578:Amidines / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D006461:Hemolysis; D006861:Hydrogen Peroxide / Q000378:metabolism; D008041:Linoleic Acids / Q000378:metabolism; D050356:Lipid Metabolism; D008081:Liposomes / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008823:Micelles; D008854:Microscopy, Electron; D010084:Oxidation-Reduction; D010713:Phosphatidylcholines / Q000378:metabolism; D011817:Rabbits; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D000578:Amidines; D000975:Antioxidants; D005609:Free Radicals; D008041:Linoleic Acids; D008081:Liposomes; D008823:Micelles; D010713:Phosphatidylcholines; D062367:ortho-Aminobenzoates; C005575:methyl linoleate; C046728:2,2'-azobis(2-amidinopropane); C057292:4-chloro-3',6'-dimethyl-2,2'-iminodibenzoate; C015735:lobenzarit; D006861:Hydrogen Peroxide