Pretreatment urinary MHPG levels as predictors of antidepressant responses to alprazolam.
The authors present preliminary data showing that pretreatment levels of urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) were significantly higher in six depressed patients who responded to the antidepressant effects of alprazolam than in six depressed patients who showed no antidepressant response.
Mooney
J J
JJ
Cole
J O
JO
Schatzberg
A F
AF
Gerson
B
B
Schildkraut
J J
JJ
D000328:Adult; D000368:Aged; D000525:Alprazolam; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy / Q000523:psychology / Q000652:urine*; D005260:Female; D006018:Glycols / Q000652:urine*; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D008875:Middle Aged; D011336:Probability; D011569:Psychiatric Status Rating Scales
D014151:Anti-Anxiety Agents; D006018:Glycols; D001569:Benzodiazepines; D008734:Methoxyhydroxyphenylglycol; D000525:Alprazolam