Effects of enkephalin on lactating rat mammary gland: in vitro studies.
We studied the in vitro effects of methionine-enkephalin and D-ala-methionine-enkephalin upon lactating rat mammary gland milk product's secretion and intracellular cyclic AMP levels. Our results show that the lactating gland does not respond to the action of these peptides and suggest that during this period this tissue lacks enkephalin receptors.
Conde
E
E
Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago.
Lavandero
S
S
Puente
J
J
Sapag-Hagar
M
M
D000818:Animals; D001665:Binding Sites; D003342:Corpus Striatum / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D004743:Enkephalin, Leucine / Q000494:pharmacology*; D004744:Enkephalin, Methionine / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007774:Lactation / Q000187:drug effects*; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000378:metabolism; D008892:Milk / Q000187:drug effects / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D000242:Cyclic AMP