Liver function in patients on long-term paracetamol (co-proxamol) analgesia.
Eleven patients on long term co-proxamol therapy for pain, in general practice, showed no abnormalities of liver or renal function, as assessed by serum prealbumin concentrations and blood enzyme and electrolyte activities. This indicates that although the preparation is hepatotoxic when taken acutely in overdose, in chronic therapeutic dosage it appears to be free from this hazard.
Hutchinson
D R
DR
Schilds
A F
AF
Parke
D V
DV
D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects*; D001219:Aspartate Aminotransferases / Q000097:blood; D011431:Dextropropoxyphene / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D005260:Female; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000097:blood; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism
D000700:Analgesics; D004338:Drug Combinations; D012709:Serum Albumin; D000082:Acetaminophen; C011800:acetaminophen, dextropropoxyphene, drug combination; D007521:Isocitrate Dehydrogenase; D001219:Aspartate Aminotransferases; D011431:Dextropropoxyphene