title: Lower CSF level of dynorphin(1-8) immunoreactivity in schizophrenic patients.
abstract: Using a highly specific and sensitive radioimmunoassay for dynorphin(1-8) (D 1-8), and a singly blind test design, we measured D(1-8) immunoreactivity (ir D 1-8) in CSF of 35 first break cases of acute schizophrenic patients. All patients were free of psychotropic medication for at least one week before the study. Another 31 neurological patients suffered from cervical arthrosis, tumor, myelopathy etc. were studied as controls. The ir D(1-8) in CSF of schizophrenic patients were significantly lower than that of controls (91.8 +/- 5.6, means +/- S.E.M., and 131.9 +/- 6.8 fmol/ml CSF respectively, p less than 0.001).
authors.forename: A Z
authors.initials: AZ
authors.lastname: Zhang
authors.forename: G Z
authors.initials: GZ
authors.lastname: Zhou
authors.forename: G F
authors.initials: GF
authors.lastname: Xi
authors.forename: N F
authors.initials: NF
authors.lastname: Gu
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Xia
authors.forename: J L
authors.initials: JL
authors.lastname: Yao
authors.forename: J K
authors.initials: JK
authors.lastname: Chang
authors.forename: R
authors.initials: R
authors.lastname: Webber
authors.forename: S
authors.initials: S
authors.lastname: Potkin
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D004399:Dynorphins / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D012559:Schizophrenia / Q000134:cerebrospinal fluid*; D012737:Sex Factors
chemical_list: D010446:Peptide Fragments; D004399:Dynorphins; C026770:dynorphin (1-8)