Characteristics of receptors and enzymes in brains of human alcoholics.
Acute and chronic ethanol administration to animals has been shown to produce changes in the turnover of numerous neurotransmitters, as well as to change the characteristics of certain neurotransmitter receptors. In the present study, brains obtained from human alcoholics and matched control subjects were examined for similar changes. In frontal cortex, the affinity of opiate receptors for dihydromorphine was significantly reduced in brains of alcoholics. Judging from animal studies, this change may reflect alterations in opiate receptor-effector coupling processes. No changes were observed in muscarinic cholinergic or beta-adrenergic receptors in humans, in contrast to animals, possibly because of the protracted abstention from alcohol among the alcoholic patients prior to death. Similarly, no changes in the activities of choline acetyltransferase, tyrosine hydroxylase or MAO-B were observed in brains of alcoholics as compared to the control population. Our studies suggest that many of the alterations witnessed during alcohol intoxication and withdrawal in animals may be more subtle in humans, or may be reversible with abstinence.
Tabakoff
B
B
Hoffman
P L
PL
Valverius
P
P
Borg
S
S
Lee
J M
JM
Jaffe
R
R
U'Prichard
D
D
DeLeon-Jones
F
F
D000437:Alcoholism / Q000378:metabolism*; D001921:Brain / Q000201:enzymology*; D001923:Brain Chemistry; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004247:DNA / Q000032:analysis; D004090:Dihydromorphine / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000032:analysis*; D011950:Receptors, Cholinergic / Q000032:analysis*; D011957:Receptors, Opioid / Q000032:analysis*; D014018:Tissue Distribution; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D007527:Isoenzymes; D011943:Receptors, Adrenergic, beta; D011950:Receptors, Cholinergic; D011957:Receptors, Opioid; D011813:Quinuclidinyl Benzilate; D004247:DNA; D004090:Dihydromorphine; D014446:Tyrosine 3-Monooxygenase; D008995:Monoamine Oxidase; D002795:Choline O-Acetyltransferase