title: The amygdala mediates the impairing effect of the selective kappa-opioid receptor agonist U-50,488 on memory in CD1 mice.
abstract: The effect of the selective kappa-opioid receptor agonist U-50,488 on passive avoidance behaviour was studied in CD1 mice bearing lesions of the amygdaloid complex. The results have shown that post-trial injections of U-50,488 in unoperated mice as well as lesions of the amygdaloid complex in untreated mice decreased retention performances. No further impairment was observed in lesioned mice treated with U-50,488, indicating that amygdala is involved in the mediation of the effects of kappa-opioid receptor agonists on memory. The possibility that kappa-opioid receptors could modulate the memory retention of CD1 mice by influencing their emotional state is discussed.
authors.affiliation: Istituto di Psicobiologia e Psicofarmacologia del CNR, Roma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Castellano
authors.forename: V
authors.initials: V
authors.lastname: Libri
authors.forename: M
authors.initials: M
authors.lastname: Ammassari-Teule
mesh_terms: D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D001143:Arousal / Q000187:drug effects; D001362:Avoidance Learning / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D011759:Pyrrolidines / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects*; D017473:Receptors, Opioid, kappa
chemical_list: D011759:Pyrrolidines; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer