title: Developmental influences of the sympathetic nervous system on rat parotid gland.
abstract: In an attempt to evaluate the effect of the sympathetic nervous system on the postnatal maturation of the parotid gland, rats were either sympathetically denervated on one side by avulsion of the superior cervical ganglion within 4 h after birth or treated with various beta-adrenoceptor blocking agents from the day of birth. Four or 9 weeks later the animals were killed and the parotid glands were subjected to quantitative morphological studies. The neonatal denervation caused a significant decrease in parotid acinar cell size and their granule content, whereas chronic beta-adrenoceptor blockade was without any effect. It is suggested that the trophic effect of the sympathetic nervous system may be due to a growth factor released from sympathetic nerve endings, which does not seem to interact with the beta-adrenoceptor system.
authors.forename: R
authors.initials: R
authors.lastname: Henriksson
authors.forename: B
authors.initials: B
authors.lastname: Carlsöö
authors.forename: A
authors.initials: A
authors.lastname: Danielsson
authors.forename: S
authors.initials: S
authors.lastname: Sundström
authors.forename: G
authors.initials: G
authors.lastname: Jönsson
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000502:physiology*; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000648:ultrastructure; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D010306:Parotid Gland / Q000187:drug effects / Q000254:growth & development* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D013562:Sympathectomy; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*
chemical_list: D000319:Adrenergic beta-Antagonists