Evidence for genetic influences on neurotransmitter content of identified neurones of Lymnaea stagnalis.
Neurotransmitter content was measured in two identified giant neurones in isogenic and wild-type populations of the freshwater pond snail Lymnaea stagnalis. The paired serotonergic cerebral giant neurones (LC1 and RC1) have higher transmitter levels and less variability in inbred animals than in wild-type animals. The transmitter content of the unpaired dopaminergic right pedal giant neurone (RPeD1) does not differ between inbred and wild-type animals in either level or variability. It is proposed that serotonin content of the cerebral giant neurones is under partial genetic control, and that animals of the wild-type population may possess a number of different alleles for the genes influencing serotonin levels. Inbreeding resulted in fixation of an allele promoting high serotonin levels. This particular wild-type population is probably already isogenic for genes influencing dopamine content in the right pedal giant neurone.
Audesirk
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G
Audesirk
T
T
McCaman
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RE
Ono
J K
JK
D000818:Animals; D004298:Dopamine / Q000032:analysis; D014644:Genetic Variation; D005838:Genotype; D008195:Lymnaea / Q000235:genetics*; D009474:Neurons / Q000032:analysis*; D018377:Neurotransmitter Agents / Q000032:analysis*; D012701:Serotonin / Q000032:analysis; D013045:Species Specificity
D018377:Neurotransmitter Agents; D012701:Serotonin; D004298:Dopamine