The effect of an aqueous extract of Tanacetum parthenium L. on arachidonic acid metabolism by rat peritoneal leucocytes.
The effect of feverfew (Tanacetum parthenium L., Schultz Bip.) as a whole plant on an aqueous extract equivalent to 20 mg dried plant per ml, has been examined on both cyclo-oxygenase and lipoxygenase activity in rat leucocytes in-vitro. At 10-25 micrograms ml-1 feverfew had no effect on the formation of arachidonate metabolites while at highest concentrations (50-200 micrograms ml-1) it inhibited both cyclo-oxygenase and lipoxygenase metabolic products.
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D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D016861:Cyclooxygenase Inhibitors; D066298:In Vitro Techniques; D007962:Leukocytes / Q000378:metabolism*; D016859:Lipoxygenase Inhibitors; D008297:Male; D010529:Peritoneal Cavity / Q000166:cytology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D016718:Arachidonic Acid