[Intracellular mechanisms of the effect of cytochrome C on various areas of the myocardium during the dynamic development of an experimental infarct].
The effectiveness of the drug was shown to depend on the number of reversibly damaged cells. The intracellular mechanisms of cytochrome C effect are thought to be related to both the possibility of its permeation through the changed cell membrane of a cardiomyocyte and the action of the drug directly on sarcolemma. Predominantly in the early periods of the study one could note a marked preservation of the ultrastructure of cardiomyocytes, a decrease of degradation of adenine nucleotides and cytochrome aa3 and in the long run limitation of the sizes of necrosis zone.
Irgashev
Sh B
ShB
Iuldashev
N M
NM
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D003574:Cytochrome c Group / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D008297:Male; D008854:Microscopy, Electron; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure*; D011817:Rabbits; D013997:Time Factors
D000227:Adenine Nucleotides; D003574:Cytochrome c Group
Nekotorye vnutrikletochnye mekhanizmy vliianiia tsitokhroma C na razlichnye zony miokarda v dinamike razvitiia éksperimental'nogo infarkta.