title: Pharmacological properties of beta-adrenoceptor blockers in relation to their antihypertensive effect.
abstract: In summary it appears that beta 2-blockade does not lower high blood pressure. Beta 1-blockade seems to be the necessary feature for the antihypertensive effect. Beta 1 ISA may attenuate the blood pressure lowering efficacy. Finally beta 2 ISA causes a favourable hemodynamic pattern in which the blood pressure lowering occurs mainly through vasodilatation. The ideal beta-blocker for hypertension should cause beta 1-blockade. It should not cause beta 2-blockade and it should possess relatively pronounced beta 2 ISA.
authors.forename: B
authors.initials: B
authors.lastname: Dahlöf
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008297:Male
chemical_list: D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents