title: Pharmacokinetics of flestolol in man: preliminary data.
abstract: The steady state pharmacokinetics of flestolol, a short acting beta-adrenoceptor blocking agent, were studied in six healthy subjects following intravenous infusion of six different doses; 18, 24, 35, 50, 75 and 100 micrograms kg-1 min-1, for 60 min. Steady state blood levels increased linearly with dose for all six subjects. The overall mean half-life was 6.5 min. The total body clearance averaged 208 ml min-1 kg-1 indicating significant extrahepatic metabolism of the drug. There were no significant changes in the half-lives or the total body clearances after the six doses, suggesting that the kinetics of flestolol are linear over the dose range studied.
authors.forename: R
authors.initials: R
authors.lastname: Achari
authors.forename: J D
authors.initials: JD
authors.lastname: Hulse
authors.forename: D
authors.initials: D
authors.lastname: Drissel
authors.forename: W L
authors.initials: WL
authors.lastname: Matier
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005464:Fluorobenzenes; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008297:Male; D011412:Propanolamines / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
chemical_list: D000319:Adrenergic beta-Antagonists; D005464:Fluorobenzenes; D011412:Propanolamines; C047847:flestolol