title: A comparison of the effects of fentanyl and alfentanil on the sleeping times of the intravenous induction agents.
abstract: The effect of increasing doses of fentanyl and alfentanil administered before four intravenous induction agents (thiopentone, methohexitone, Althesin and etomidate) on the sleeping time were studied in mice. A biphasic pattern of sleeping time was noted with the more rapidly metabolized and eliminated compounds. Possible explanations are discussed.
authors.forename: A E
authors.initials: AE
authors.lastname: Dingwall
authors.forename: B J
authors.initials: BJ
authors.lastname: Pleuvry
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage / Q000494:pharmacology*; D015760:Alfentanil; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051379:Mice; D012890:Sleep / Q000187:drug effects*
chemical_list: D000759:Adjuvants, Anesthesia; D000777:Anesthetics; D015760:Alfentanil; D005283:Fentanyl