Serum myoglobin concentrations are decreased by beta-adrenergic stimulation.
During infusion with adrenaline in healthy subjects there was a more than 50% reduction in serum myoglobin concentrations. This effect appeared to be specific for beta-adrenergic stimulation, since no changes were seen after prior IV beta-blockade with propranolol, nor did noradrenaline affect the serum myoglobin levels. Oral beta-blockade with propranolol raised the basal serum levels of myoglobin and enhanced the exercise-related rise in serum myoglobin concentrations during ergometer cycling to exhaustion. These observations thus indicate that the beta-adrenergic system affects serum myoglobin concentrations. This should be kept in mind in the evaluation of myoglobin measurements for clinical purposes, and might reflect a physiologically relevant mechanism.
Ljunghall
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Roxin
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Venge
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Akerström
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D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D003404:Creatinine / Q000097:blood; D004837:Epinephrine / Q000494:pharmacology; D005080:Exercise Test; D006801:Humans; D008297:Male; D009211:Myoglobin / Q000097:blood*; D009638:Norepinephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*; D013268:Stimulation, Chemical; D001613:beta 2-Microglobulin / Q000097:blood
D000319:Adrenergic beta-Antagonists; D009211:Myoglobin; D001613:beta 2-Microglobulin; D011433:Propranolol; D003404:Creatinine; D009638:Norepinephrine; D004837:Epinephrine