[Treatment of cryptorchism with LHRH nasal spray].
53 prepubertal boys with untreated cryptorchidism were investigated in this study. 38 boys had unilateral, and 15 boys had bilateral cryptorchidism. 200 micrograms synthetic LHRH in a 0.2% aqueous solution (Cryptocur) were sprayed 3 times daily into each nostril (total dosage: 1.2 mg/d). The duration of therapy was 4 weeks. The boys were examined by palpation before, and then 2, 4 weeks and 6 months after commencement of treatment. Descent was achieved in 67.6% of testes; in the boys with unilateral cryptorchidism descent was achieved in 57.9% and in the boys with bilateral cryptorchidism in 80.0%. Follow-up control 6 months later showed relapse in 14 cases (30.4%). Treatment of cryptorchidism by intranasal application of LHRH, 3 times 400 micrograms/d is very effective. Administration is simple, painless and well tolerated. Follow-up is recommended, however, in view of the relatively high relapse rate.
Borkenstein
M
M
Zobel
V
V
D000281:Administration, Intranasal; D002648:Child; D002675:Child, Preschool; D003456:Cryptorchidism / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male
D007987:Gonadotropin-Releasing Hormone
Behandlung des Maldescensus testis mit LHRH-Nasalspray.