title: Excitatory and inhibitory responses of Purkinje cells, in the rat cerebellum in vivo, induced by excitatory amino acids.
abstract: Responses of rat cerebellar Purkinje cells to iontophoretically administered excitatory amino acids have been studied in vivo. Responses to N-methyl-D-aspartate (NMDA) were either biphasic (excitation followed by inhibition) or purely inhibitory and were antagonized by the selective NMDA-receptor antagonist, 2-amino-5-phosphonovalerate. Quisqualate and kainate either excited or induced biphasic responses, in these neurones, which were only reduced by amino acid antagonists that acted at non-NMDA receptors. The excitatory amino acid-induced inhibitions were also antagonized by the selective gamma-aminobutyric acid (GABA) antagonist, picrotoxin, suggesting that they were indirectly mediated via GABAergic inhibitory interneurones, which could be excited via NMDA and non-NMDA receptors.
authors.forename: J E
authors.initials: JE
authors.lastname: Quinlan
authors.forename: J
authors.initials: J
authors.lastname: Davies
mesh_terms: D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate; D010069:Oxadiazoles / Q000494:pharmacology; D011689:Purkinje Cells / Q000187:drug effects*; D016318:Quisqualic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D005971:Glutamates; D010069:Oxadiazoles; D011963:Receptors, GABA-A; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D016202:N-Methylaspartate; D016318:Quisqualic Acid; D007608:Kainic Acid