title: Manson's schistosomiasis in Brazil: 11-year evaluation of successful disease control with oxamniquine.
abstract: This prospective study has shown that oxamniquine treatment controlled endemic schistosomiasis mansoni in a defined rural population in Castro Alves, north-east Brazil. Data before and after treatment spanning 11 years were collected for a cohort of 191 residents. Before treatment (1974-77), the cohort was heavily infected and the prevalence of associated hepatomegaly (greater than 86%) and splenomegaly (greater than 17%) was stable. The cohort was treated when oxamniquine became available in 1977; during the next 8 years, over 80% received further treatments from the Brazilian programme for the control of schistosomiasis. With treatment, the incidence of splenomegaly fell (10% to 2%) and the splenomegaly regression rate increased (43% to 91%). Declining disease rates were coincident with substantial falls in the prevalence and intensity of Schistosoma mansoni infections. The final prevalence rates for hepatomegaly (31%) and splenomegaly (3%) in Castro Alves approached the corresponding rates of 10% and 1% in a comparable uninfected control population.
authors.forename: A C
authors.initials: AC
authors.lastname: Sleigh
authors.forename: R
authors.initials: R
authors.lastname: Hoff
authors.forename: K E
authors.initials: KE
authors.lastname: Mott
authors.forename: J H
authors.initials: JH
authors.lastname: Maguire
authors.forename: J T
authors.initials: JT
authors.lastname: da França Silva
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil; D002648:Child; D005243:Feces / Q000469:parasitology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009600:Nitroquinolines / Q000627:therapeutic use*; D010073:Oxamniquine / Q000627:therapeutic use*; D010270:Parasite Egg Count; D010808:Physical Examination; D011446:Prospective Studies; D012424:Rural Population; D012555:Schistosomiasis mansoni / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D009600:Nitroquinolines; D010073:Oxamniquine