Oral cancer in children under 15 years of age. A clinicopathological and virological study.
11 malignant tumours of the oral region in children under 15 years of age were diagnosed in Finland during the 20-year period from 1961 to 1980; the age adjusted annual incidence rate being 0.31 per 1,000,000 children. 5 cases were intraoral cancer and 5 cases malignant tumours of the major salivary glands. The formalin-fixed tumours were studied using the in situ DNA hybridization technique for Adenovirus, group II, Epstein-Barr and human papillomavirus, type 16. For the first time, evidence was provided for the presence of Epstein-Barr virus in a malignant salivary gland tumour, implicating a possible etiological role for this virus in salivary gland neoplasms.
Kärjä
J
J
Department of Otolaryngology, University of Kuopio, Finland.
Syrjänen
S
S
Usenius
T
T
Vornanen
M
M
Collan
Y
Y
D000293:Adolescent; D002648:Child; D005260:Female; D005387:Finland; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000453:epidemiology*; D010307:Parotid Neoplasms / Q000453:epidemiology* / Q000382:microbiology; D012468:Salivary Gland Neoplasms / Q000453:epidemiology*