[Effect of somatostatin on hypercalcemia stimulated gastric juice and exocrine pancreas secretion in the human].
Hypercalcemia produced in healthy volunteers by intravenous infusions of calciumgluconolactobionate increased outputs of gastric acid, pepsin, and pancreatic enzymes. Hypercalcemia did not affect gallbladder emptying and serum gastrin values. Further, intravenous somatostatin (SRIF, 5 micrograms/kg.h) markedly inhibited secretion of gastric acid (p less than 0.01), pepsin (p less than 0.05), and pancreatic enzymes (p less than 0.02) stimulated by hypercalcemia. SRIF-inhibited outputs were below basal values. These results indicate that the inhibitory effect of SRIF on exocrine cells of the human gastrointestinal tract can not be reversed by extracellular hypercalcemia.
Lenz
T
T
Kölbel
C
C
Herzog
P
P
Holtermüller
K H
KH
D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000097:blood; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006801:Humans; D006934:Hypercalcemia / Q000503:physiopathology*; D008049:Lipase / Q000378:metabolism*; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010434:Pepsin A / Q000378:metabolism; D013004:Somatostatin / Q000494:pharmacology*; D014357:Trypsin / Q000378:metabolism*
D005755:Gastrins; D013004:Somatostatin; D008049:Lipase; D014357:Trypsin; D010434:Pepsin A; D002118:Calcium
Effekt von Somatostatin auf die durch Hyperkalzämie stimulierte Magensaft- und exokrine Pankreassekretion beim Menschen.