Facilitated transport of sodium salicylate across an artificial lipid membrane by Azone.
The ability of Azone (1-dodecylazacylcoheptan-2-one), a recently developed penetration enhancer, to facilitate the transport of sodium salicylate across an artificial lipid membrane has been investigated using the rotating diffusion cell, a well defined model for percutaneous absorption. Azone was found to be capable of enhancing the transport of the salicylate anion across an isopropyl myristate membrane, by using a pH gradient as the chemical driving force. The results indicate that Azone may be capable of forming ion pairs with anionic drugs.
Hadgraft
J
J
Walters
K A
KA
Wotton
P K
PK
D001381:Azepines / Q000032:analysis*; D004058:Diffusion; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000032:analysis*; D008567:Membranes, Artificial; D012459:Salicylates / Q000032:analysis*; D020156:Salicylic Acid
D001381:Azepines; D008055:Lipids; D008567:Membranes, Artificial; D012459:Salicylates; C035229:laurocapram; D020156:Salicylic Acid