The effects of Ro 15-1788 on anxiolytic self-administration in the rhesus monkey.
The ability of a benzodiazepine antagonist, Ro 15-1788, to modify the self-administration of anxiolytics was determined in rhesus monkeys. Lever-press responding was maintained in four monkeys under a fixed-ratio 10 schedule of drug delivery in daily sessions of 2 hr duration. Responding was maintained either by flurazepam, lorazepam or pentobarbital. When responding was stable for each of these drugs, a range of doses of a benzodiazepine antagonist, Ro 15-1788 (0.0001-10 mg/kg, IM), was given 5 min prior to a session. At some doses the antagonist increased responding for lorazepam and flurazepam whereas pentobarbital self-administration was largely unaffected or reduced. These results suggest that Ro 15-1788 was able to specifically modify the effects of benzodiazepines responsible for drug-maintained performance.
Johanson
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Schuster
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D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001570:Benzodiazepinones / Q000008:administration & dosage*; D004347:Drug Interactions; D005260:Female; D005442:Flumazenil; D005479:Flurazepam / Q000008:administration & dosage; D008140:Lorazepam / Q000008:administration & dosage; D008253:Macaca mulatta; D008297:Male; D010424:Pentobarbital / Q000008:administration & dosage; D012054:Reinforcement, Psychology; D012646:Self Administration
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D005442:Flumazenil; D010424:Pentobarbital; D005479:Flurazepam; D008140:Lorazepam