[Effect of hydrocortisone on synaptic transmission in surviving slices of the olfactory cortex from the rat brain].
A study was made of the effect of bath-applied hydrocortisone (10(-4) M) on excitatory transmission of the lateral olfactory tract (LOT) - superficial pyramidal cell synapse of the rat olfactory cortex slice. Population EPSP and IPSP were depressed for 6-12 min., then they were increased (60 min.) by hydrocortisone. Recovery of evoked potentials was long (40-60 min.) at washing of slices hy a normal incubation medium. Habituation of synaptic potentials during LOT repeating stimulation was deteriorated by hydrocortisone application in perfusion solution. The data obtained were considered to be adaptive functions of the nervous system to a stressor.
Mokrushin
A A
AA
Bagaeva
T R
TR
Gerasimova
I A
IA
Emel'ianov
N A
NA
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D046508:Culture Techniques; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D006185:Habituation, Psychophysiologic / Q000187:drug effects / Q000502:physiology; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009832:Olfactory Nerve / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013569:Synapses / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors; D014022:Tissue Survival
C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone
Vliianie gidorkortizona na sinapticheskuiu peredachu v perezhivaiushchikh srezakh oboniatel'noĭ kory mozga krys.