Melanotic neuroectodermal tumour of infancy (MNTI). Immunohistochemical and ultrastructural study of a case.
A case of melanotic neuroectodermal tumour of infancy (MNTI) which occurred in the left lower jaw of a 15-months old child was studied by electron microscopy and immunohistochemical methods to verify the neural crest origin of this tumour. Two cell population were observed: pigment melanocyte-like cells and non-pigmented nerve-like cells. Immunohistochemical analysis with neuron-specific enolase (NSE) and S-100 protein visualized two cell subtypes in the non-pigmented cell population. The combined ultrastructural findings and immunohistochemical data confirm the neural crest origin of MNTI.
Melissari
M
M
Dept. of Histopathology, University of Parma, Italy.
Tragni
G
G
Gaetti
L
L
Gabrielli
M
M
Bozzetti
A
A
Raffaini
M
M
D003593:Cytoplasm / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology / Q000648:ultrastructure*; D008544:Melanocytes / Q000648:ultrastructure; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology / Q000648:ultrastructure*