Indium-111 labelled monoclonal antibody to placental alkaline phosphatase in in the detection of neoplasms of testis, ovary, and cervix.
A monoclonal antibody (H17E2) against placental alkaline phosphatase (PLAP) and testicular placental-like alkaline phosphatase was labelled with indium-111 and used in radioimmunoscintigraphy of 15 patients known or suspected to have germ-cell carcinoma of the testis or carcinoma of the ovary or cervix. Good images of neoplastic lesions were obtained in most patients with active disease. In 1 patient with testicular teratoma and elevated human chorionic gonadotropin who had a normal computed tomography scan, the labelled antibody located microscopic disease in a lymph node, which was then removed. No false positive localisation was seen in patients with PLAP-negative tumours or sites of inflammation. This method may be helpful in the diagnosis, staging, and monitoring of PLAP-positive neoplasms of testicular, ovarian, and cervical origin.
Epenetos
A A
AA
Snook
D
D
Hooker
G
G
Begent
R
R
Durbin
H
H
Oliver
R T
RT
Bodmer
W F
WF
Lavender
J P
JP
D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000032:analysis* / Q000276:immunology; D000911:Antibodies, Monoclonal; D004796:Clinical Enzyme Tests; D005260:Female; D006801:Humans; D007204:Indium; D008297:Male; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013737:Testis / Q000201:enzymology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging
D000911:Antibodies, Monoclonal; D011868:Radioisotopes; D007204:Indium; D000469:Alkaline Phosphatase