Neonatal thyrotoxicosis treated with exchange transfusion and Lugol's iodine.
An infant with neonatal thyrotoxicosis was born to a mother who had become euthyroid after subtotal thyroidectomy for Graves' disease. Exchange transfusion resulted in a 50% decrease of serum thyroxine levels and thyroid stimulating immunoglobulins. After 10 days mild thyrotoxic signs reappeared with high serum thyroxine levels, which were treated successfully with Lugol's iodine for 4 weeks. TSI was undetectable at 7 weeks of age. TSI was present in breast milk.
Wit
J M
JM
Gerards
L J
LJ
Vermeulen-Meiners
C
C
Bruinse
H W
HW
D000328:Adult; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000151:congenital* / Q000628:therapy; D007074:Immunoglobulin G / Q000032:analysis; D018828:Immunoglobulins, Thyroid-Stimulating; D007231:Infant, Newborn; D007454:Iodides / Q000627:therapeutic use*; D008895:Milk, Human / Q000032:analysis; D012996:Solutions; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000097:blood
D007074:Immunoglobulin G; D018828:Immunoglobulins, Thyroid-Stimulating; D007454:Iodides; D012996:Solutions; D013974:Thyroxine; C010389:Lugol's solution