The RAD6 gene of yeast: a link between DNA repair, chromosome structure and protein degradation?
Among the DNA repair mutants of the yeast Saccharomyces cerevisiae, the rad6 mutants are characterized by a highly pleiotropic phenotype. Most remarkably, these mutants are sensitive towards a variety of DNA-damaging agents and deficient in mutation induction. The RAD6 gene has been cloned and most recently, ubiquitin-conjugating activity of the Rad6 protein has been demonstrated. In this brief review, the properties of rad6 mutants are discussed in the light of these new findings. The available data hint at a connection between DNA repair, mutagenesis, chromosome structure and protein degradation.
Siede
W
W
Stanford University, School of Medicine, Department of Pathology, CA 94305.
D002875:Chromosomes / Q000528:radiation effects; D004260:DNA Repair; D005656:Fungal Proteins / Q000378:metabolism; D005800:Genes, Fungal; D008025:Ligases / Q000235:genetics; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000528:radiation effects*; D029701:Saccharomyces cerevisiae Proteins; D044763:Ubiquitin-Conjugating Enzymes; D014452:Ubiquitins / Q000378:metabolism
D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins; D014452:Ubiquitins; C471606:RAD6 protein, S cerevisiae; D044763:Ubiquitin-Conjugating Enzymes; D008025:Ligases