Determination of bioavailability on the basis of tachycardia after intravenous and oral administration of fenoterol, orciprenaline and salbutamol in non-anaesthetized rats.
Three beta-sympathomimetics, fenoterol, orciprenaline and salbutamol, were tested for their tachycardia effect in conscious rats sedated with brotizolam. The tachycardia after oral and intravenous administration and the time-effect curves were used for the determination of the bioavailability. In these experiments, fenoterol and orciprenaline showed better bioavailability than salbutamol. The tachycardic time effects of fenoterol and orciprenaline were of shorter duration than that of salbutamol.
Muacevic
G
G
D000284:Administration, Oral; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000420:Albuterol / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D001682:Biological Availability; D004562:Electrocardiography; D005260:Female; D005280:Fenoterol / Q000378:metabolism / Q000494:pharmacology; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D009921:Metaproterenol / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D000318:Adrenergic beta-Agonists; D005280:Fenoterol; D009921:Metaproterenol; D000420:Albuterol