title: Identification of human immunodeficiency virus (HIV) envelope type-specific T helper cells in an HIV-infected individual.
abstract: Two T helper cell clones recognizing the gp 120 envelope protein of HIV were generated from the peripheral blood of a healthy seropositive individual. These cells were type specific as they proliferated and produced IL 2 when stimulated by an epitope in the amino-terminal half of gp 120 of HIVSF2, but not by a similar region of HIVZr6, a Zairian HIV-1 isolate. These two viruses differ by 26% in the deduced amino sequence of the gp 120 protein. Moreover, the antigenic site(s) recognized by the cloned T cells are distinct from those recognized by envelope-specific antibodies. These observations have important implications for the development and use of anti-HIV vaccines.
authors.affiliation: Cancer Research Institute, University of California, School of Medicine, San Francisco 94143.
authors.forename: C M
authors.initials: CM
authors.lastname: Walker
authors.forename: K S
authors.initials: KS
authors.lastname: Steimer
authors.forename: K L
authors.initials: KL
authors.lastname: Rosenthal
authors.forename: J A
authors.initials: JA
authors.lastname: Levy
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000382:microbiology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D002999:Clone Cells; D015699:HIV Envelope Protein gp120; D006679:HIV Seropositivity; D006801:Humans; D012191:Retroviridae Proteins / Q000032:analysis*; D006377:T-Lymphocytes, Helper-Inducer / Q000032:analysis*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D015699:HIV Envelope Protein gp120; D012191:Retroviridae Proteins