GABA inhibits excitatory neurotransmission in rat pelvic ganglia.
Intravenous GABA inhibited, in a bicuculline-sensitive manner, contractions of the urinary bladder induced by preganglionic nerve stimulation in urethane anaesthetized rats, while it had no significant effect on contractions produced by postganglionic nerve stimulation. In addition, intravenous GABA strongly inhibited DMPP-induced bladder contractions; this effect was also prevented by bicuculline. These experiments suggest that GABA inhibits excitatory neurotransmission in rat pelvic ganglia through a mechanism involving, at least in part, the activation of postsynaptic GABA A receptors.
Maggi
C A
CA
Santicioli
P
P
Meli
A
A
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology; D004558:Electric Stimulation; D005724:Ganglia / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000187:drug effects*; D001743:Urinary Bladder / Q000294:innervation*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D004246:Dimethylphenylpiperazinium Iodide; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline