Serotonin inhibits the depolarization-evoked release of endogenous glutamate from rat cerebellar nerve endings.
Glutamic acid (Glu) has been proposed as the neurotransmitter of cerebellar granule cells. 5-Hydroxytryptamine (5-HT) afferents project to the cerebellar cortex. The possible interaction between 5-HT and Glu was investigated by studying the effect of 5-HT on Glu release. The Ca2+-dependent depolarization-evoked release of endogenous Glu from superfused rat cerebellar synaptosomes was potently inhibited by 5-HT. Methiothepin, but not ketanserin, cinanserin or methysergide, antagonized 5-HT. It is concluded that the release of Glu can be modulated by 5-HT through receptors sited on Glu terminals. These receptors belong to the 5-HT1-type.
Maura
G
G
Ricchetti
A
A
Raiteri
M
M
D000818:Animals; D002531:Cerebellum / Q000378:metabolism*; D005071:Evoked Potentials; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D008297:Male; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects; D013574:Synaptosomes / Q000378:metabolism
D005971:Glutamates; D011985:Receptors, Serotonin; D012701:Serotonin; D018698:Glutamic Acid; D011188:Potassium