title: Growth hormone secretion and pancreatic function following somatostatin infusion in ducks (Anas platyrhynchos).
abstract: The intravenous infusion of somatostatin (800 ng/kg min) reduced the concentration of growth hormone (GH) in the plasma of 4 to 5, 6 to 7 and 8 to 9 week-old ducklings, but not in adult ducks. The inhibition of GH secretion was not due to accompanying changes in pancreatic function, since the infusion of a lower dose of somatostatin (200 ng/kg min) increased glucagon release and decreased plasma free fatty acids (FFA), as observed with the higher dose, but had no effect on GH concentrations. The withdrawal of somatostatin inhibition resulted in rebound GH secretion in immature birds, the magnitude of which was directly related to the pre-treatment level. Following somatostatin infusion (800 ng/kg min) no modification in GH concentration was observed in adult ducks. These results demonstrate that basal GH release in young birds is not autonomous and is suppressible by somatostatin. The data provide further evidence for age-related changes in the control of avian GH and insulin release and for the independence of the effects of somatostatin on the pituitary and pancreas glands.
authors.forename: M T
authors.initials: MT
authors.lastname: Strosser
authors.forename: S
authors.initials: S
authors.lastname: Harvey
authors.forename: C
authors.initials: C
authors.lastname: Foltzer
authors.forename: P
authors.initials: P
authors.lastname: Mialhe
mesh_terms: D000367:Age Factors; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004372:Ducks / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005934:Glucagon / Q000097:blood; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D007263:Infusions, Parenteral / Q000662:veterinary; D007328:Insulin / Q000097:blood; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000502:physiology; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D013004:Somatostatin; D013006:Growth Hormone; D005934:Glucagon