Intravenous magnesium in acute myocardial infarction.
In a double-blind, placebo-controlled study, 273 patients with suspected acute myocardial infarction (AMI) were randomised to receive either magnesium intravenously or placebo immediately on admission to hospital. Of 130 patients with proven AMI 56 received magnesium and 74 received placebo. During the first 4 weeks after treatment mortality was 7% in the magnesium group and 19% in the placebo group. In the magnesium group 21% of patients had arrhythmias that needed treatment, compared with 47% in the placebo group. No adverse effects of intravenous magnesium were observed.
Rasmussen
H S
HS
McNair
P
P
Norregard
P
P
Backer
V
V
Lindeneg
O
O
Balslev
S
S
D000368:Aged; D001145:Arrhythmias, Cardiac / Q000401:mortality; D002986:Clinical Trials as Topic; D003402:Creatine Kinase / Q000097:blood; D004311:Double-Blind Method; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007527:Isoenzymes; D008274:Magnesium / Q000008:administration & dosage* / Q000097:blood; D015636:Magnesium Chloride; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D009206:Myocardium / Q000201:enzymology; D011897:Random Allocation; D012770:Shock, Cardiogenic / Q000401:mortality; D013997:Time Factors
D007527:Isoenzymes; D015636:Magnesium Chloride; D003402:Creatine Kinase; D008274:Magnesium