Brain microsomal oxidation of delta 8- and delta 9-tetrahydrocannabinol.
Brain microsomes of mice, rats, guinea pigs and rabbits catalyzed the oxidation of delta 8- and delta 9-tetrahydrocannabinol to their monohydroxylated metabolites. The most prominent metabolite was the 4'-hydroxylated metabolite on the pentyl side chain of the cannabinoids in all species tested, except that the 5'-hydroxylation of delta 9-tetrahydrocannabinol was most abundant in the guinea pig. These results are quite different from the metabolic profile of the cannabinoids with hepatic microsomes.
Watanabe
K
K
Department of Hygienic Chemistry, School of Pharmacy, Hokuriku University, Kanazawa, Japan.
Tanaka
T
T
Yamamoto
I
I
Yoshimura
H
H
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D013759:Dronabinol / Q000378:metabolism*; D006168:Guinea Pigs; D006900:Hydroxylation; D013058:Mass Spectrometry; D051379:Mice; D008861:Microsomes / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D011817:Rabbits; D051381:Rats
D013759:Dronabinol; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases