title: Hypercortisolism, diarrhea with steatorrhea, and massive proteinuria due to pheochromocytoma.
abstract: Amelioration or cure of hypertension, hypercortisolism, diarrhea with steatorrhea, and massive proteinuria resulted from excision of a pheochromocytoma that contained immunoreactive ACTH, VIP, and somatostatin. Ectopic ACTH production by the tumor was clearly the cause of the hypercortisolism, and the possible involvement of VIP and somatostatin in the diarrhea and steatorrhea was considered. The response to tumor removal suggested that the mesangioproliferative glomerulonephritis shown on renal biopsy was also a paraneoplastic phenomenon.
authors.forename: J W
authors.initials: JW
authors.lastname: Interlandi
authors.forename: R F
authors.initials: RF
authors.lastname: Hundley
authors.forename: A G
authors.initials: AG
authors.lastname: Kasselberg
authors.forename: D N
authors.initials: DN
authors.lastname: Orth
authors.forename: W D
authors.initials: WD
authors.lastname: Salmon
authors.forename: J N
authors.initials: JN
authors.lastname: Sullivan
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D000308:Adrenocortical Hyperfunction / Q000209:etiology*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D002446:Celiac Disease / Q000209:etiology*; D003967:Diarrhea / Q000209:etiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D011507:Proteinuria / Q000209:etiology*; D013004:Somatostatin / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
chemical_list: D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone