title: Peptides and feeding.
abstract: This report reviews the hypothesis that peptides play a role in appetite modulation, stressing that the available evidence is predominantly pharmacological and thus caution needs to be taken in assigning physiological significance at this time. Two peptide systems have been postulated--a peripheral satiety system, typified by the gastrointestinal hormone cholecystokinin and a central feeding system driven by the opioid peptides and neuropeptide Y. This review also discusses the putative role of peptides in the anorexia of aging, drinking elicited by feeding and as mediators of the autonomic effects seen in association with ventromedial hypothalamic lesions.
authors.forename: J E
authors.initials: JE
authors.lastname: Morley
authors.forename: A S
authors.initials: AS
authors.lastname: Levine
authors.forename: B A
authors.initials: BA
authors.lastname: Gosnell
authors.forename: J E
authors.initials: JE
authors.lastname: Mitchell
authors.forename: D D
authors.initials: DD
authors.lastname: Krahn
authors.forename: S E
authors.initials: SE
authors.lastname: Nizielski
mesh_terms: D000375:Aging; D000818:Animals; D001067:Appetite Depressants; D001341:Autonomic Nervous System / Q000502:physiology; D002415:Cats; D002766:Cholecystokinin / Q000494:pharmacology; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D004285:Dogs; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D006963:Hyperphagia / Q000209:etiology; D007033:Hypothalamus, Middle / Q000502:physiology; D008297:Male; D009419:Nerve Tissue Proteins / Q000502:physiology; D009478:Neuropeptide Y; D018377:Neurotransmitter Agents / Q000502:physiology; D010455:Peptides / Q000494:pharmacology / Q000502:physiology*; D051381:Rats; D012528:Satiety Response / Q000502:physiology
chemical_list: D001067:Appetite Depressants; D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D018377:Neurotransmitter Agents; D010455:Peptides; D002766:Cholecystokinin; D003346:Corticotropin-Releasing Hormone