title: Tissue atenolol levels following chronic beta-adrenoceptor blockade using oral atenolol in dogs.
abstract: Tissue atenolol concentrations are high following chronic continuous beta-adrenoceptor blockade in dogs. Furthermore, significant concentrations of this poorly lipid soluble drug are found within the central nervous system after chronic dosing. It is suggested that all beta-adrenoceptor blocking agents may enter the central nervous system in significant and sufficient quantities to account for a central antihypertensive action of this group of compounds. Sequestration of beta-adrenoceptor agents in the CNS or other tissues may account for other clinically observed effects including adaptive effects.
authors.forename: M K
authors.initials: MK
authors.lastname: Davies
authors.forename: J
authors.initials: J
authors.lastname: McAinsh
mesh_terms: D000818:Animals; D001262:Atenolol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D004334:Drug Administration Schedule; D006339:Heart Rate / Q000187:drug effects; D007545:Isoproterenol / Q000037:antagonists & inhibitors; D014018:Tissue Distribution
chemical_list: D001262:Atenolol; D007545:Isoproterenol