title: Effect of implanted ethylene-vinyl alcohol copolymer matrices containing 5-fluorouracil on Ehrlich ascites carcinoma.
abstract: The antitumour activity of ethylene-vinyl alcohol (EVAl) copolymer matrices containing 5-fluorouracil (5-FU) was evaluated against Ehrlich ascites carcinoma in mice. A prolongation of the life-span of tumour-bearing mice following intraperitoneal implantation of therapeutic matrices was noted. These results indicated that EVAl matrices containing 5-FU may be effective in cancer chemotherapy. Matrices composed of EVAl copolymer could be useful vehicles for implanted, inserted, or surface-applied delivery systems for anticancer agents.
authors.forename: S
authors.initials: S
authors.lastname: Miyazaki
authors.forename: S
authors.initials: S
authors.lastname: Takeuchi
authors.forename: M
authors.initials: M
authors.lastname: Sugiyama
authors.forename: M
authors.initials: M
authors.lastname: Takada
authors.forename: M
authors.initials: M
authors.lastname: Hosokawa
authors.forename: Y
authors.initials: Y
authors.lastname: Koga
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004343:Drug Implants; D005472:Fluorouracil / Q000008:administration & dosage* / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011145:Polyvinyls / Q000008:administration & dosage*
chemical_list: D004343:Drug Implants; D011145:Polyvinyls; C020320:ethylene-vinyl alcohol copolymer; D005472:Fluorouracil