Studies of hepatic tolerance of polyvinylpyrrolidone in the rat.
Intraperitoneal polyvinylpyrrolidone in amounts much larger than used in povidone-iodine for peritonitis or for adhesion prophylaxis was administered to rats. No adverse effects on hepatic reticulo-endothelial function could be detected using dynamic hepatic scintigraphy and fewer histochemical changes occurred than expected.
Moody-Jones
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D
Karran
S J
SJ
D000818:Animals; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011205:Povidone / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D011205:Povidone