title: Interferon gamma does not induce antiviral resistance in T lymphocytes.
abstract: We compared the activity of human recombinant alpha and gamma interferons (IFNs) on normal T lymphocytes and various T cell lines. IFN gamma, unlike IFN alpha, did not promote the antiviral state in these cells, or induce the activity of 2'-5' oligoadenylate synthetase. The lack of antiviral effect was observed using an RNA virus (VSV) and a DNA virus (HSV, type 1) as challenger viruses.
authors.affiliation: Institute of Microbiology, University, Torino, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Zucca
authors.forename: G
authors.initials: G
authors.lastname: Gribaudo
authors.forename: B
authors.initials: B
authors.lastname: Ferrara
authors.forename: G
authors.initials: G
authors.lastname: Cavallo
authors.forename: S
authors.initials: S
authors.lastname: Landolfo
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism; D015153:Blotting, Western; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology; D011994:Recombinant Proteins; D018139:Simplexvirus; D013601:T-Lymphocytes / Q000276:immunology*; D014407:Tumor Cells, Cultured; D014721:Vesicular stomatitis Indiana virus
chemical_list: D007370:Interferon Type I; D007376:Interleukin-2; D011994:Recombinant Proteins; D007371:Interferon-gamma; D015088:2',5'-Oligoadenylate Synthetase