title: Correlation of histologic types of carcinoma of the uterine cervix and human papillomavirus and herpes simplex virus type 2 DNA sequences in the uterine cervical biopsies.
abstract: Forty patients with invasive cancer of cervix from New Delhi were examined for the presence of human papillomavirus (HPV) and herpes simplex virus (HSV) type 2 DNA sequences in a Southern hybridization assay. Data were analysed according to the histologic type of cancer. HPV DNA sequences were detected in 82.5% biopsies and HSV-2 DNA sequences were found in 10% biopsies. HPV-16 DNA sequences were found either alone or together with HPV-18 and/or HSV-2 Bgl II N fragment in 55% biopsies from keratinizing squamous cell carcinoma, whereas HPV-18 sequences were found in 35% biopsies. Similarly, 50% biopsies from patients with non keratinizing squamous cell carcinoma contained HPV-16 DNA and 38.9% biopsies had HPV-18 DNA. HSV-2 Bgl II N DNA sequences were present in 10% biopsies which were also positive for HPV-16 and/or HPV-18 DNA sequences. Two biopsies from adenocarcinoma of uterine cervix contained HPV-18 and HPV-16 DNA sequences. Therefore, no significant correlation seems to exist between HPV-types and histologic types or grades of differentiation of tumor.
authors.affiliation: Department of Microbiology, All India Institute of Medical Sciences, New Delhi.
authors.forename: P
authors.initials: P
authors.lastname: Seth
authors.forename: H
authors.initials: H
authors.lastname: Kaur
authors.forename: R
authors.initials: R
authors.lastname: Kaur
authors.forename: K
authors.initials: K
authors.lastname: Verma
authors.forename: N
authors.initials: N
authors.lastname: Manjunath
mesh_terms: D000230:Adenocarcinoma / Q000382:microbiology* / Q000473:pathology; D015139:Blotting, Southern; D002294:Carcinoma, Squamous Cell / Q000382:microbiology* / Q000473:pathology; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005814:Genes, Viral; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics*; D018139:Simplexvirus / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000382:microbiology* / Q000473:pathology
chemical_list: D004279:DNA, Viral