[Clinical study of the beta-blocker chlorpropanol (tobanum) in hypertension patients].
The antihypertensive effect and tolerance of chlorpropanol was determined in 30 patients with hypertonic disease. The treatment was carried out only with tobanum as an open experiment with a dose from 10 to 30 mg. Before and towards the end of the treatment, the following indices were calculated from the simultaneous record of M-echocardiogram of left ventricle, ACG, PhCG and ECG: stroke volume (SV), minute volume (MV) cardiac index (CI), ejection fraction (EF), mean velocity of circumferential fibres shortening (Vcf), and peripheral vascular resistance (PVR). Chlorpropanol normalized the pressure in 83.3% of the treated, reducing the systolic pressure with 14.9%, and the diastolic--with 15.1%. The reduction of the pressure in hyperkinetic type of circulation is associated with the reduction of CI (p less than 0.05) as result from the slowed down cardiac rate (p less than 0.001), in hypokinetic type--with the reduction of PVR (p less than 0.05), and in eukinetic--with the normalization of the ratio between those two parameters. EF was not changed during the treatment, Vcf was reduced (p less than 0.045), but remained within the physiological limits. Chlorpropanol is with pronounced negative chronotropic effect. It has a good tolerance.
Sirakova
V
V
Penkov
N
N
Kaponov
Kh
Kh
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000009:adverse effects / Q000627:therapeutic use*; D013318:Stroke Volume / Q000187:drug effects; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D011412:Propanolamines; C025725:tobanum
Klinichno prouchvane na beta-blokera khlorpropanol (tobanum) pri bolni ot khipertonichna bolest.