Antibodies in the renin-angiotensin system.
Antibody interactions with the endothelial cell membrane glycoprotein angiotensin-converting enzyme (Kininase II) in vivo exhibit features of aggregation and capping with resultant shedding similar to those events described in several in vitro isolated cell systems. Requirements for divalent ligand binding and participation of cytoskeletal elements are demonstrated in vivo as well. Persistence of antigen in immune complexes with complement interaction appear to be necessary to induce an inflammatory response. Abrogation of this response occurs when circumstances permit antigenic modulation with disappearance of the immune complex.
Caldwell
P R
PR
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology; D007703:Peptidyl-Dipeptidase A / Q000276:immunology; D012084:Renin-Angiotensin System
D000906:Antibodies; D007703:Peptidyl-Dipeptidase A