Effects of caffeine and chlor-desmethyldiazepam on fighting behavior of mice with different reactivity baselines.
The effects of various doses of caffeine and of chlor-desmethyldiazepam on footshock-induced aggressive behavior were examined in mice with different baselines of aggressiveness. Caffeine significantly increased the number of fighting episodes with all the doses tested. This was more evident in mice with low rather than in those with high basal rates of agonistic response. Caffeine caused the appearance of minimal convulsive signs in mice subjected to a threshold electroshock which did not produce any seizure in the controls; it also increased metrazol toxicity. Chlor-desmethyldiazepam enhanced fighting behavior at doses of 0.04 and 0.08 mg/kg, but decreased it at 1.25 mg/kg. The first two doses produced the same effects as caffeine on electroshock test, but did not influence metrazol toxicity.
Traversa
U
U
de Angelis
L
L
Della Loggia
R
R
Bertolissi
M
M
Nardini
G
G
Vertua
R
R
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D002110:Caffeine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology; D003975:Diazepam / Q000031:analogs & derivatives*; D004597:Electroshock; D008297:Male; D051379:Mice; D003708:Nordazepam / Q000031:analogs & derivatives* / Q000494:pharmacology; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D002110:Caffeine; D003708:Nordazepam; C013434:chlordesmethyldiazepam; D003975:Diazepam; D003913:Dextroamphetamine; D010433:Pentylenetetrazole