alpha-Adrenoceptor agonists applied in the area of the nucleus tractus solitarii in the rat: effect of anesthesia on cardiovascular responses.
We investigated the blood pressure and heart rate responses to unilateral local application of norepinephrine or clonidine in the area of the nucleus tractus solitarii (NTS) of conscious rats and rats anesthetized by 3 general anesthetics commonly used in cardiovascular research. In the conscious state, microinjection of either substance produced an immediate, sharp increase in blood pressure and decrease in heart rate with a gradual return to baseline over a period of more than 30 min. However, light ether anesthesia, nembutal, or urethane drastically reduced, abolished or even reversed the pressor effect of local microinjection of the same substance. Our results suggest that in conscious rats, the initial effect of alpha agonists in the NTS area is to modulate baroreceptor reflexes towards higher blood pressure levels and that general anesthesia may significantly alter or mask the cardiovascular responses to various experimental manipulations.
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D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000768:Anesthesia, General; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology; D003243:Consciousness; D006339:Heart Rate / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects*; D008845:Microinjections; D009638:Norepinephrine / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000316:Adrenergic alpha-Agonists; D003000:Clonidine; D009638:Norepinephrine