A relationship between hepatic metabolism of reduced lantadene A and its toxicity in rats and sheep.
The metabolism of the cholestatic triterpene acid reduced lantadene A has been studied in susceptible and resistant rats and in sheep which are susceptible to intoxication. Sheep and susceptible female rats produced a similar major metabolite and rats produced a second metabolite which was a glucuronide. These metabolites were also observed in extracts of bile canalicular membranes prepared from intoxicated rats. Resistant male and female rats produced a similar major metabolite which was different to those synthesized by susceptible animals. It is concluded that in rats and sheep there is a correlation between the type of metabolites produced in the liver and the susceptibility to intoxication by reduced lantadene A.
Pass
M A
MA
Goosem
M W
MW
Pollitt
S
S
D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D005260:Female; D008099:Liver / Q000378:metabolism*; D008297:Male; D009828:Oleanolic Acid / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep; D013045:Species Specificity; D014315:Triterpenes / Q000378:metabolism* / Q000633:toxicity
D014315:Triterpenes; C017004:22 beta-angeloyloxy-oleanolic acid; D009828:Oleanolic Acid