Proto-oncogenes, growth factor genes, receptor genes, differentiation genes and structural rearrangements in human cancer.
Information on chromosomal structural rearrangements in leukemia and solid tumors was retracted from a computerized databank and the literature. A binomial test procedure was used to determine the statistical significance of the observed numbers of breaks. Some 131 human cancer-specific chromosomal structural rearrangements were also taken from the literature. The results showed that breakage and deletion occurred preferentially in bands known to contain proto-oncogenes, growth factor genes, receptor genes and differentiation genes. Therefore, chromosomal structural rearrangements could be used to find and map new genes involved in the genesis and/or progression of neoplasia.
De Braekeleer
M
M
SOREP, University of Quebec, Chicoutimi, Canada.
D002454:Cell Differentiation; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D015321:Gene Rearrangement; D005796:Genes; D006133:Growth Substances / Q000235:genetics*; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D011519:Proto-Oncogenes; D011956:Receptors, Cell Surface / Q000235:genetics*; D014178:Translocation, Genetic
D006133:Growth Substances; D011956:Receptors, Cell Surface