Ionization constants and partition coefficients of 1-arylpiperazine derivatives.
The ionization constant (pKa) and liposolubilities (log P) of fourteen 1-arylpiperazines were determined by n-octanol/buffer partition. pKa varied little across the entire series. Log P values ranged from less than 1 to about 2 for the highly lipophilic derivatives of the preset series. The results are discussed in relation to the extent to which these derivatives, known to be centrally active, may enter the brain.
Caccia
S
S
Fong
M H
MH
Urso
R
R
D002021:Buffers; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007700:Kinetics; D008055:Lipids; D008567:Membranes, Artificial; D010879:Piperazines / Q000032:analysis*; D012995:Solubility; D013329:Structure-Activity Relationship
D002021:Buffers; D008055:Lipids; D008567:Membranes, Artificial; D010879:Piperazines