[Effect of neuroleptics, narcotic analgesics and narcotic agents on the absorptive activity of the small intestine].
It was shown in experiments on preliminary operated on dogs that in conditions of analgesia achieved by the administration of neuroleptics and narcotic analgetics in doses applied for premedication, there are no significant disorders in the acid-alkaline state and the absorbing function of the small intestine. The administration of narcotic agents in doses providing the surgical stage of narcosis, inhibits the absorption in the intestine and the deeper the developing metabolic acidosis gets, the higher proves the inhibition. The obtained data show that the inhibition of absorption is not conditioned directly by the narcosis but is the result of disorders in the gaseous homeostasis with further disorders in metabolic processes in the intestine wall.
Koval'skaia
K S
KS
Matveev
S B
SB
Papaninov
A S
AS
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D004285:Dogs; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism; D009294:Narcotics / Q000494:pharmacology*
D000701:Analgesics, Opioid; D014150:Antipsychotic Agents; D009294:Narcotics
Vliianie neĭroleptikov, narkoticheskikh anal'getikov i narkoticheskikh sredstv na vsasyvatel'nuiu aktivnost' tonkoĭ kishki.