DL-sodium lactate reduces alpha 1-adrenergic receptor binding in rat and mouse brain.
DL-Sodium lactate decreases the density of alpha 1-adrenergic receptors in rat brain membranes in vitro, an effect that is not present for several other neuroreceptors under similar conditions. Moreover, similar effects on specific 3H-prazosin binding to alpha 1-adrenergic receptors can be seen in the mouse brain after intravenous (i.v.) administration of DL-sodium lactate. Since these effects can be observed with i.v. doses of DL-sodium lactate only slightly higher than the doses needed to provoke panic attacks in susceptible patients, it seems possible that similar changes in central neurotransmission might be involved in the biological mechanism underlying the induction of panic attacks by DL-sodium lactate.
Rick
S
S
Beckmann
H
H
Müller
W E
WE
D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage; D000818:Animals; D001921:Brain / Q000187:drug effects*; D003864:Depression, Chemical; D004347:Drug Interactions; D007773:Lactates / Q000008:administration & dosage / Q000494:pharmacology*; D019344:Lactic Acid; D008297:Male; D051379:Mice; D011224:Prazosin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000378:metabolism
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D007773:Lactates; D011942:Receptors, Adrenergic, alpha; D019344:Lactic Acid; D011224:Prazosin