[3H]-domperidone labels only a single population of receptors which convert from high to low affinity for dopamine in rat brain.
Dopamine recognized and competed for a single population of [3H]-domperidone-binding sites in rat striatum and olfactory tubercle when tested in the presence of sodium ions and guanine nucleotide [Gpp(NH)p]. In the absence of Na+ and Gpp(NH)p, however, dopamine recognized two components of [3H]-domperidone binding. Thus, [3H]-domperidone labelled only a single population of dopamine receptors (type D2) which fully converted from high to low affinity for dopamine. These results agree with those found previously using [3H]-spiperone and [3H]-YM-09151-2.
Grigoriadis
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D
Seeman
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P
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001549:Benzamides / Q000494:pharmacology; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D004294:Domperidone / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009830:Olfactory Bulb / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*; D013134:Spiperone / Q000494:pharmacology
D014150:Antipsychotic Agents; D001549:Benzamides; D011954:Receptors, Dopamine; D013134:Spiperone; D004294:Domperidone; C030265:nemonapride; D004298:Dopamine