title: [Angiotensin-converting enzyme and 1,25-dihydroxyvitamin D3 in hypercalcemia of unknown origin].
abstract: Sarcoidosis of the kidneys and liver without radiologically demonstrable lung involvement in a 44-year-old woman was shown to be the cause of a hypercalcaemia syndrome. The hypercalcaemia was presumably due to an increased production of 1,25-(OH)2-vitamin D3 which--like the increased angiotensin converting enzyme--is produced in the epithelioid and giant cells. Corticoid treatment normalized serum calcium and ACE levels and improved renal function. These observations demonstrate that measurement of ACE and 1,25-(OH)2-vitamin D3 levels is helpful in the differential diagnosis of hypercalcaemia, in view of the possibility of sarcoidosis, and should be among the diagnostic tests.
authors.affiliation: Medizinische Klinik I, Städtische Krankenanstalten Köln-Merheim.
authors.forename: P
authors.initials: P
authors.lastname: Leidig
authors.forename: H P
authors.initials: HP
authors.lastname: Baum
authors.forename: B
authors.initials: B
authors.lastname: Krakamp
authors.forename: K
authors.initials: K
authors.lastname: Finke
authors.forename: G
authors.initials: G
authors.lastname: Bönner
mesh_terms: D000328:Adult; D001706:Biopsy; D002117:Calcitriol / Q000097:blood*; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis / Q000473:pathology
chemical_list: D007703:Peptidyl-Dipeptidase A; D002117:Calcitriol
vernacular_title: Angiotensin-converting-Enzym und 1,25-Dihydroxy-Vitamin D3 bei unklarer Hypercalcämie.