Acquired immunodeficiency syndrome in the child of a haemophiliac.
Oral thrush developed during the second month of life in the 5-month-old son of a patient with haemophilia A. He did not feed well, and interstitial pneumonitis, lymphadenopathy, hepatosplenomegaly, and a cellular immune defect consistent with the acquired immunodeficiency syndrome (AIDS) followed. Both parents had signs of pre-AIDS during the year before their son's illness. Transmission presumably occurred in 3 steps: parenterally, via factor VIII concentrate in the haemophiliac; heterosexually, from the haemophiliac to his wife; and vertically, from mother to infant, or via close paternal-infant or maternal-infant contact. This first report of AIDS in the child of a haemophiliac supports the theory that AIDS is caused by an infectious agent. Concentrate-treated haemophiliacs may transmit this agent to their spouses or children, resulting in pre-AIDS or AIDS.
Ragni
M V
MV
Urbach
A H
AH
Kiernan
S
S
Stambouli
J
J
Cohen
B
B
Rabin
B S
BS
Winkelstein
A
A
Gartner
J C
JC
Zitelli
B Z
BZ
Malatack
J J
JJ
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics* / Q000276:immunology / Q000635:transmission; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D002675:Child, Preschool; D017977:Deltaretrovirus / Q000276:immunology; D005169:Factor VIII / Q000627:therapeutic use; D005260:Female; D006467:Hemophilia A / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D006801:Humans; D007223:Infant; D008297:Male
D000914:Antibodies, Viral; D005169:Factor VIII