H2 receptor antagonists and human granulopoiesis.
The effect of 2 H2 receptor antagonists (ranitidine and cimetidine) on the in vitro growth of human granulomonopoietic precursors (CFU-GM) was studied. Ranitidine, although having an anti H2 receptor activity much greater than that of cimetidine, displays the same toxicity for CFU-GM.
Aglietta
M
M
Stacchini
A
A
Sanavio
F
F
Piacibello
W
W
D002927:Cimetidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006098:Granulocytes / Q000166:cytology*; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D011899:Ranitidine / Q000494:pharmacology
D006635:Histamine H2 Antagonists; D002927:Cimetidine; D011899:Ranitidine