Nicotine is a competitive antagonist for H1-receptors in smooth muscles.
The effects of nicotine on histamine-induced contractions in the aortic strip from rabbit and in the intestinal and airway smooth muscles from guinea-pig were examined. Nicotine inhibited the contractile effects of histamine in a concentration-dependent manner in all investigated smooth muscle preparations having identical pA2 values. Data obtained in this study indicate that nicotine has a histamine H1-receptor antagonistic property with a lower activity than mepyramine for H1-receptors as verified by the calculated pA2 values.
Ercan
Z S
ZS
Türker
R K
RK
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001667:Binding, Competitive / Q000187:drug effects; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D011817:Rabbits; D014132:Trachea / Q000187:drug effects
D006634:Histamine H1 Antagonists; D009538:Nicotine; D006632:Histamine; D011738:Pyrilamine; D009638:Norepinephrine