[Bone changes in diabetes mellitus].
An epidemiological study was carried out to elucidate whether or not there are bone changes peculiar to diabetes. The subjects of this study were 100 diabetic patients. The MD method and the Jikei method for classification of spinal bone atrophy were employed as the tools of this study. Cases with a severity of Grade I or higher were detected in 18% (18 patients) of the subjects by the MD method and 19% (19 patients) by the Jikei method. When factor analysis was performed on osteopenia cases on the basis of patient background, it was found that the incidence of osteopenia increased in proportion to the severity of diabetes. Serum Ca, P and Al-P were determined in all subjects, and biochemical endocrinological factors such as Ca-regulating hormone were determined in 60 subjects. 24,25(OH)2D3 was found to be decreased in 65% of the subjects. The disturbance of vitamin D metabolism thus appears to be generally present in patients with diabetic osteopenia.
Saito
K
K
Department of Orthopaedic Surgery, Jikei University, School of Medicine, Tokyo, Japan.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000097:blood*; D002762:Cholecalciferol / Q000378:metabolism*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000453:epidemiology* / Q000209:etiology; D010758:Phosphorus / Q000097:blood
D002762:Cholecalciferol; D010758:Phosphorus; D002116:Calcitonin; D000469:Alkaline Phosphatase; D002118:Calcium