[Intragastric acidity, serum gastrin and serum levels of the H2 receptor oxmetidine administered by continuous infusion].
The effect of 2-[2-(5-methyl-4-imidazolmethylthio)-ethyl-amino]-5-(3,4- methylendioxybenzyl)-4-pyrimidone dihydrochloride (oxmetidine) as continuous i.v. infusion over 11 1/2 h was tested with the doses of 12.5, 25 and 50 mg/h following an infusion of 200 mg over 30 min. In eight healthy male volunteers the parameters of gastric acid secretion were examined over 12 h as well as plasma oxmetidine and serum gastrin concentrations. Basal acid secretion was dose-dependently reduced from 53.1 mmol/12 h to minimally 3.2 mmol/12 h. A pH greater than or equal to 5 was reached for each volunteer under each dose, but even with the highest dose (50 mg/h) of oxmetidine a suppression of acid secretion up to the end of the 12-h experiment could not be observed.
Wichmann
G C
GC
Körber
R
R
Fölsch
U R
UR
D000328:Adult; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005755:Gastrins / Q000097:blood*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D007263:Infusions, Parenteral; D008297:Male; D013997:Time Factors
D005755:Gastrins; D006635:Histamine H2 Antagonists; D007093:Imidazoles; C027703:oxmetidine
Intragastrale Azidität, Serumgastrin- und Wirkstoffspiegel bei Gabe des H2-Rezeptorantagonisten Oxmetidin als Dauerinfusion.