N-methyl-D-aspartate receptors mediate tonic vasodepressor control in the caudal ventrolateral medulla of the rat.
Microinjections of N-methyl-D-aspartate (NMDA) into the caudal ventrolateral medulla of the rat led to a decrease in arterial pressure whereas 2-amino-5-phosphonovalerate injected bilaterally into this region produced hypertension and blocked the depressor effect of aortic nerve stimulation. High K+ stimulation via push-pull cannula caused a calcium-dependent release of endogenous glutamate from the region. These results provide evidence for the NMDA receptor system involved in tonic vasodepressor control in the rat caudal ventrolateral medulla.
Kubo
T
T
Department of Pharmacology, Yokohama City University School of Medicine, Japan.
Kihara
M
M
D000818:Animals; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D014666:Vasomotor System / Q000502:physiology*
D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter