Cytogenetic study of malignant histiocytosis transplanted into nude mice; presence of translocation between chromosomes 5 and 6 and a unique marker (13q+).
Fluid from a pleural effusion in a child with malignant histiocytosis was grafted into nude mice. Cytogenetic studies were performed on the xenografted cells which revealed a diploid karyotype with a translocation t (5;6) and a marker (13q+). This study reports a new rearrangement which has not been described previously in malignant histiocytosis.
Soulie
J
J
Rousseau-Merck
M F
MF
Mouly
H
H
Nezelof
C
C
D000818:Animals; D002648:Child; D002869:Chromosome Aberrations / Q000473:pathology*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002901:Chromosomes, Human, 13-15; D002905:Chromosomes, Human, 4-5; D006801:Humans; D008206:Lymphatic Diseases / Q000235:genetics*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010996:Pleural Effusion / Q000473:pathology; D014178:Translocation, Genetic