Sequential development of enzymes of gluconeogenesis and glucose synthesis in fetal goat liver.
The development of three key gluconeogenic enzymes, viz. phosphoenolpyruvate carboxykinase, fructose 1.6-bisphosphatase and glucose 6-phosphatase, and the gluconeogensis by liver slices were studied during development of goat fetus. The three enzymes develop in a sequential and time dependent manner, and the glucose 6-phosphatase develops last at around 100 days of gestation. Glucose synthesis by fetal liver slices was observed after 120 days of gestation. It may be concluded that the gluconeogenic sequence is operative well before birth and the goat fetus synthesizes its own glucose after 100 days of gestation.
Dhanotiya
R S
RS
Department of Biochemistry, University of Indore, India.
Bhardwaj
R
R
D000818:Animals; D005314:Embryonic and Fetal Development; D006597:Fructose-Bisphosphatase / Q000378:metabolism*; D005943:Gluconeogenesis; D005947:Glucose / Q000096:biosynthesis; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D006041:Goats; D008099:Liver / Q000196:embryology* / Q000201:enzymology; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000378:metabolism*
D006597:Fructose-Bisphosphatase; D005952:Glucose-6-Phosphatase; D010729:Phosphoenolpyruvate Carboxykinase (GTP); D005947:Glucose