title: [Antioxidative properties and degradation of serum proteins by active oxygen forms (O2-., OCl-) generated by stimulated neutrophils].
abstract: The ability of major serum proteins (albumin, immunoglobulin G) and free radical scavenger proteins (ceruloplasmin, superoxide dismutase, transferrin) to interact with O2-. and OCl- was studied. The interaction between serum proteins and OCl- was shown to be nonspecific and cause protein degradation. During SDS polyacrylamide gel electrophoresis ceruloplasmin and transferrin were degraded in the highest degree. Protein damage was also recorded by fluorescence changes. It is suggested that the damaging influence of active oxygen species secreted by stimulated neutrophils into the extracellular space can be abolished only by ceruloplasmin.
authors.forename: B P
authors.initials: BP
authors.lastname: Sharonov
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Govorova
authors.forename: S N
authors.initials: SN
authors.lastname: Lyzlova
mesh_terms: D001798:Blood Proteins / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D006997:Hypochlorous Acid / Q000097:blood / Q000378:metabolism*; D008163:Luminescent Measurements; D009504:Neutrophils / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D010587:Phagocytosis; D013050:Spectrometry, Fluorescence
chemical_list: D001798:Blood Proteins; D006878:Hydroxides; D017665:Hydroxyl Radical; D006997:Hypochlorous Acid; D010100:Oxygen
vernacular_title: Antiokislitel'nye svoĭstva i degradatsiia belkov syvorotki aktivnymi formami kisloroda (O2-., OCl-), generiruemymi stimulirovannymi neĭtrofilami.