Dose-response curves for vecuronium during halothane and neurolept anaesthesia: single bolus versus cumulative method.
The purpose of this study was to compare the incremental, cumulative dose method and the single bolus injection technique for construction of dose-response curves for vecuronium. Dose-response curves were determined in 77 patients divided into four groups according to the anaesthetic given and the method used for construction of dose-response curves. The regression lines corresponding to the four dose-response curves were found to be parallel. For vecuronium ED50 during neurolept anaesthesia was found to be 28 micrograms kg-1 with the single bolus injection technique and 35.2 micrograms kg-1 with the incremental, cumulative dose method (P less than 0.05). During halothane anaesthesia, ED50 was found to be 25.7 micrograms kg-1 and 26.2 micrograms kg-1, respectively (P greater than 0.05). Potentiation of vecuronium by halothane was found with the cumulative method only. It is concluded that the incremental, cumulative dose method is not suitable for potency determinations of vecuronium.
Ording
H
H
Skovgaard
L T
LT
Engbaek
J
J
Viby-Mogensen
J
J
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D004305:Dose-Response Relationship, Drug; D006221:Halothane; D006801:Humans; D008875:Middle Aged; D009458:Neuroleptanalgesia; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage*; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology; D010197:Pancuronium / Q000008:administration & dosage / Q000031:analogs & derivatives*; D009435:Synaptic Transmission / Q000187:drug effects; D014673:Vecuronium Bromide
D009466:Neuromuscular Blocking Agents; D014673:Vecuronium Bromide; D010197:Pancuronium; D006221:Halothane