Acute nonlymphocytic leukemia following lung cancer in a patient with a constitutional supernumerary chromosome.
A patient with a constitutional bisatellited supernumerary marker chromosome developed a large cell lung carcinoma and subsequent acute nonlymphocytic leukemia (ANLL) of the M2 type showing an (8;21) translocation and del(9). The ANLL-M2 appeared to be independent of the lung carcinoma. The presence of the supernumerary chromosome might have been associated with the development of the two diseases.
Minamihisamatsu
M
M
Division of Radiation Hazards, National Institute of Radiological Sciences, Chiba, Japan.
Gregorio
J S
JS
Onozawa
Y
Y
Ishihara
T
T
D018288:Carcinoma, Small Cell / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology
D005819:Genetic Markers