title: Geriatric clinical pharmacology.
abstract: Age-related physiologic changes may significantly alter drug disposition and dynamics in the elderly. This is especially important for cardiovascular drugs, because they are used with such high frequency in the geriatric population. Alterations in the pharmacokinetics and pharmacodynamics of several drugs used to treat cardiovascular disease have been demonstrated in the elderly. Knowledge of these alterations may aid in more rational prescribing of cardiovascular drugs in the geriatric population.
authors.forename: M L
authors.initials: ML
authors.lastname: Rocci
authors.forename: P H
authors.initials: PH
authors.lastname: Vlasses
authors.forename: W B
authors.initials: WB
authors.lastname: Abrams
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000378:metabolism; D000368:Aged; D000375:Aging; D000889:Anti-Arrhythmia Agents / Q000378:metabolism; D001682:Biological Availability; D001823:Body Composition; D002317:Cardiovascular Agents / Q000627:therapeutic use; D004068:Digestive System Physiological Phenomena; D004077:Digoxin / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D007668:Kidney / Q000502:physiology; D007700:Kinetics; D008099:Liver / Q000502:physiology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011802:Quinidine / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D002317:Cardiovascular Agents; D004364:Pharmaceutical Preparations; D004077:Digoxin; D011802:Quinidine