title: Susceptibility of Campylobacter pylori isolated from pediatric and adult patients to seven new quinolone antibiotics and nalidixic acid.
abstract: The susceptibility of 26 strains of Campylobacter pylori to 7 new quinolone antibiotics and nalidixic acid was determined. All strains were resistant to nalidixic acid. Difloxacin, A-56620, A-62254, and ciprofloxacin were equally effective against the test strains with MICs ranging from 0.06 to 2.0 micrograms/ml. Fleroxacin, amifloxacin, perfloxacin, and norfloxacin showed only moderate activity against C. pylori. The new quinolone agents, which are bactericidal, may prove useful in the eradication of C. pylori from the gastric mucosa.
authors.affiliation: Department of Pediatrics, Case Western Reserve University, School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, Ohio.
authors.forename: V
authors.initials: V
authors.lastname: Hupertz
authors.forename: H
authors.initials: H
authors.lastname: Carr
authors.forename: S J
authors.initials: SJ
authors.lastname: Czinn
mesh_terms: D000328:Adult; D002167:Campylobacter / Q000187:drug effects* / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology*
chemical_list: D015363:Quinolones; D009268:Nalidixic Acid