Alcoholic dementia: a hypothesis.
Dementia in alcoholics may depend to a large degree on cortical cholinergic deficiency resulting from involvement of key basal forebrain nuclei in a Wernicke-type pathology. Other neurotransmitter functions may also be implicated. Such a model accounts for the difficulty in establishing alcoholic dementia as a distinct disorder and in distinguishing it from Alzheimer's disease.
Lishman
W A
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D000425:Alcohol Amnestic Disorder / Q000209:etiology; D002540:Cerebral Cortex / Q000473:pathology; D003704:Dementia / Q000209:etiology*; D006801:Humans; D008960:Models, Psychological; D011604:Psychoses, Alcoholic / Q000209:etiology*; D014899:Wernicke Encephalopathy / Q000378:metabolism / Q000473:pathology