Effects of enalapril on lymphocyte sodium, potassium, magnesium and calcium levels in patients with severe congestive heart failure.
Fifteen patients (median age 73 years) with severe congestive heart failure were treated with Enalapril for a total of 12 weeks with a significant improvement in their right atrial pressures and in their functional state. Renal function, serum potassium, magnesium and calcium levels were unchanged. Lymphocyte sodium, potassium and calcium levels were generally lower than control values throughout the study but these differences were only statistically significant early in the study. Lymphocyte magnesium levels were unchanged. These findings are in contrast to those previously reported in the literature for such patients treated with conventional diuretics.
Abraham
A S
AS
Department of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
Balkin
J
J
Rosenmann
D
D
Brooks
B A
BA
Eylath
U
U
Zion
M M
MM
D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000097:blood; D002986:Clinical Trials as Topic; D004573:Electrolytes / Q000097:blood*; D004656:Enalapril / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008274:Magnesium / Q000097:blood; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood
D004573:Electrolytes; D004656:Enalapril; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium