title: [Severe chronic Epstein-Barr virus infection with natural killer cell defect].
abstract: Chronic Epstein-Barr virus infection was confirmed serologically in a 27-year-old man with pneumonia, splenomegaly, pancytopenia, arthritis, neuropathy and psychological changes. Immunological tests revealed a defect in the cytotoxic activity of the natural killer cells. Treatment with high doses of acyclovir intravenously and of antimycotic drugs dramatically and lastingly improved the patient's condition.
authors.affiliation: Abteilung Immunologie und Transfusionsmedizin, Medizinischen Hochschule Hannover.
authors.forename: K
authors.initials: K
authors.lastname: Hartung
authors.forename: S
authors.initials: S
authors.lastname: Le Blanc
authors.forename: A
authors.initials: A
authors.lastname: Franz
authors.forename: R
authors.initials: R
authors.lastname: Jacobs
authors.forename: C
authors.initials: C
authors.lastname: Wittekind
authors.forename: G W
authors.initials: GW
authors.lastname: Bornkamm
authors.forename: R E
authors.initials: RE
authors.lastname: Schmidt
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D002908:Chronic Disease; D003601:Cytotoxicity Tests, Immunologic; D003937:Diagnosis, Differential; D006566:Herpesviridae Infections / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D004854:Herpesvirus 4, Human; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male
chemical_list: D000212:Acyclovir
vernacular_title: Schwere chronische Epstein-Barr-Virus-Infektion mit Natural-Killer-Zell-Defekt.