Cocaine potentiates the responses to methacholine and noradrenaline in the rat vas deferens.
The ability of cocaine (10 microM) to potentiate the contractile responses of the epididymal half of the rat vas deferens to methacholine was reversed by prazosin. Prazosin also partially reversed the ability of cocaine to increase the spontaneous overflow of 3H following loading of the tissue with [3H]noradrenaline. We suggest that cocaine potentiated the responses to methacholine by stimulating, directly or indirectly, alpha 1-adrenoceptors.
Bradley
L
L
Doggrell
S A
SA
Edmonds
S C
SC
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004357:Drug Synergism; D066298:In Vitro Techniques; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology*; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014649:Vas Deferens / Q000187:drug effects
D008688:Methacholine Compounds; D003042:Cocaine; D009638:Norepinephrine; D011224:Prazosin