title: Quantitative HPLC determination of [99mTc]-pertechnetate in radiopharmaceuticals and biological samples--I. Technique development.
abstract: Techniques have been developed which allow HPLC (high performance liquid chromatography) to be used for the quantitative determination of [99mTc]pertechnetate in radiopharmaceuticals and biological samples. An instrumental technique accounts for 99mTc species which do not elute from the HPLC column, while a chemical technique obviates interferences caused by Sn(II). These two techniques are incorporated into an anion exchange HPLC procedure which is applied to the determination of [99mTc]pertechnetate in 99mTc-diphosphonate radiopharmaceuticals and biological samples.
authors.affiliation: Department of Chemistry, University of Cincinnati, OH 45221.
authors.forename: T Z
authors.initials: TZ
authors.lastname: Zhou
authors.forename: W W
authors.initials: WW
authors.lastname: Hirth
authors.forename: W R
authors.initials: WR
authors.lastname: Heineman
authors.forename: E
authors.initials: E
authors.lastname: Deutsch
mesh_terms: D002138:Calibration; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D013670:Sodium Pertechnetate Tc 99m / Q000032:analysis*; D013669:Technetium Tc 99m Medronate / Q000032:analysis
chemical_list: D013670:Sodium Pertechnetate Tc 99m; D013669:Technetium Tc 99m Medronate