[Polymyxin biosynthesis by Bacillus polymyxa during growth limitation by the nutritional sources].
The synthesis of the antibiotic polymyxin M was studied under the conditions of batch and continuous cultivation of Bacillus polymyxa var. Ross whose growth was limited with glucose, phosphate and ammonium nitrogen. Polymyxin M was synthesized when the culture growth decelerated as a result of its limitation with the above compounds. Different amounts of the antibiotic were synthesized depending on the type of a limiting factor. The highest productiveness was found in the case of glucose limitation. The optimal conditions for polymyxin M synthesis were established under the conditions of one-step continuous cultivation.
Lykov
V V
VV
Khovrychev
M P
MP
Polin
A N
AN
D001407:Bacillus / Q000254:growth & development* / Q000378:metabolism; D003470:Culture Media / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D011113:Polymyxins / Q000032:analysis / Q000096:biosynthesis*
D003470:Culture Media; D011113:Polymyxins
Biosintez polimiksina Bacillus polymyxa pri limitatsii rosta istochnikami pitaniia.