title: Bethanechol versus antiacids in the treatment of gastroesophageal reflux.
abstract: To compare the efficacy of bethanechol in the treatment of gastroesophageal reflux with that of antiacids, a prospective, cross-over study was undertaken, in which 20 affected infants and children were randomized into two groups on 6-week alternate bethanechol and antiacids oral medication. Patients were evaluated clinically and by esophageal pH-metry before and after each treatment. Clinical score amelioration was achieved earlier than reflux number reduction and with similar incidence in both groups of patients, irrespectively to the initial medication; moreover, the differences in the degree of improvement between the two groups after either treatment were not found to be significant. These results fail to show that bethanechol is more effective than antiacids in controlling gastroesophageal reflux; moreover, bethanechol is more difficult to administer and offers a higher rate of undesired side effects.
authors.forename: P
authors.initials: P
authors.lastname: Levi
authors.forename: F
authors.initials: F
authors.lastname: Marmo
authors.forename: C
authors.initials: C
authors.lastname: Saluzzo
authors.forename: D
authors.initials: D
authors.lastname: Dell'Olio
authors.forename: N
authors.initials: N
authors.lastname: Ansaldi
authors.forename: L
authors.initials: L
authors.lastname: Giuliani
authors.forename: O
authors.initials: O
authors.lastname: Guardamagna
authors.forename: M
authors.initials: M
authors.lastname: Mostert
authors.forename: A
authors.initials: A
authors.lastname: Ponzone
mesh_terms: D000536:Aluminum Hydroxide / Q000627:therapeutic use*; D000863:Antacids / Q000627:therapeutic use*; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000627:therapeutic use*; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004338:Drug Combinations / Q000627:therapeutic use; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008274:Magnesium / Q000627:therapeutic use*; D008276:Magnesium Hydroxide / Q000627:therapeutic use*; D011897:Random Allocation
chemical_list: D000863:Antacids; D001626:Bethanechol Compounds; D004338:Drug Combinations; D018723:Bethanechol; C013591:aluminum hydroxide, magnesium hydroxide, drug combination; D000536:Aluminum Hydroxide; D008274:Magnesium; D008276:Magnesium Hydroxide