Effect of somatostatin in necrolytic migratory erythema of glucagonoma.
A 63-year-old woman with necrolytic migratory erythema associated with a glucagonoma in the pancreas is described. The diagnosis was suggested on the basis of a characteristic lesion in skin biopsy. Infusion of somatostatin (25 micrograms/h) for 48 hours was followed by a rapid and almost complete healing of the skin eruptions. Serum glucagon was depressed during infusion. No significant changes in plasma glucose were detected. As the patient experienced a cramp-like sensation after cessation of somatostatin infusion, a tail-off period in the infusion program is advocated. The pathogenesis of necrolytic erythema in glucagonoma is discussed.
Elsborg
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L
Glenthøj
A
A
D007516:Adenoma, Islet Cell / Q000150:complications*; D004890:Erythema / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D005260:Female; D005935:Glucagonoma / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications*; D012867:Skin / Q000473:pathology; D013004:Somatostatin / Q000627:therapeutic use*
D013004:Somatostatin