Wilms' tumor complicated by veno-occlusive disease of the liver (VOD): current concepts and a case report.
A 2-year-old boy, undergoing treatment for Wilms' tumor, developed in some respects unusual manifestations of veno-occlusive disease of the liver. Reporting the case, we also review the current clinical and radiological concepts of this neglected complication of cancer therapy. Misinterpretation of symptoms and signs is probably rather common and may prove fatal. Recognition of the disorder calls for immediate discontinuation of chemotherapy and irradiation. Supportive intensive care is frequently necessary. Following recovery, cautiously tailored tumor therapy may be reinstated.
Nybonde
T
T
Department of Radiology, St. Göran's Children's Hospital, Stockholm, Sweden.
Eklöf
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O
Björk
O
O
D002675:Child, Preschool; D003131:Combined Modality Therapy; D006504:Hepatic Veno-Occlusive Disease / Q000209:etiology*; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D014057:Tomography, X-Ray Computed; D009396:Wilms Tumor / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy