title: Prophylactic phenoxybenzamine in the prevention of postoperative retention of urine after vaginal repair: a prospective randomized double-blind trial.
abstract: To investigate the effect of prophylactic phenoxybenzamine on the bladder emptying after vaginal repair operations, 41 consecutive patients, who underwent the Manchester operation or an anterior + posterior repair because of genital descensus, were allocated at random to either prophylactic phenoxybenzamine (PBZ-group) or placebo treatment in the postoperative course. Prophylactic phenoxybenzamine was found to produce an improved emptying function of the bladder, leading to a statistically significant reduced number of acute urinary retentions (P = 0.029), decreased time until spontaneous voiding (P = 0.026) and reduced volume of residual urine (P = 0.018). Furthermore, a reduced incidence of urinary tract infections was found in the PBZ-group. Prophylactic phenoxybenzamine treatment is recommended as an alternative to routine bladder drainage in preventing urinary retention following vaginal repair operations for genital descensus.
authors.forename: G
authors.initials: G
authors.lastname: Lose
authors.forename: P
authors.initials: P
authors.lastname: Lindholm
mesh_terms: D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D010643:Phenoxybenzamine / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control; D014549:Urinary Incontinence / Q000209:etiology; D014552:Urinary Tract Infections / Q000209:etiology; D014555:Urination Disorders / Q000517:prevention & control*; D014596:Uterine Prolapse / Q000601:surgery; D014621:Vagina / Q000601:surgery*
chemical_list: D010643:Phenoxybenzamine