Expression of the glutathione S-transferase placental form in human lung carcinomas.
Expression of glutathione S-transferase placental form (GST-pi) in human lung carcinoma tissue taken at autopsy or biopsy was investigated immunohistochemically. All of 34 cases of squamous cell carcinomas, including poorly, moderately and well-differentiated examples were shown to stain positively for GST-pi. Poorly differentiated adenocarcinomas were, however, negatively stained (0/5 cases), while moderately and well differentiated adenocarcinomas were found to stain with GST-pi at rates of 69% (9/13 cases) and 71% (5/7 cases), respectively. Six cases of small cell carcinomas examined were all negative. The results indicate that GST-pi may be a useful marker for non-small cell type lung cancer, especially squamous cell carcinoma which is in agreement with findings for rat lung neoplastic lesions reported previously.
Eimoto
H
H
Department of Oncological Pathology, Nara Medical College, Japan.
Tsutsumi
M
M
Nakajima
A
A
Yamamoto
K
K
Takashima
Y
Y
Maruyama
H
H
Konishi
Y
Y
D000230:Adenocarcinoma / Q000201:enzymology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000201:enzymology; D002294:Carcinoma, Squamous Cell / Q000201:enzymology; D005260:Female; D005982:Glutathione Transferase / Q000032:analysis*; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D010920:Placenta / Q000201:enzymology*
D014408:Biomarkers, Tumor; D005982:Glutathione Transferase