title: Attrition of trisomies as a maternal screening device. An explanation of the association of trisomy 21 with maternal age.
abstract: Analysis of published data indicates that the increased rate of trisomy 21 pregnancies with advancing maternal age is due to failure of a postulated maternal screening process between fertilisation and recognition. This mechanism may also operate in other trisomies.
authors.forename: Z
authors.initials: Z
authors.lastname: Stein
authors.forename: W
authors.initials: W
authors.lastname: Stein
authors.forename: M
authors.initials: M
authors.lastname: Susser
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D004314:Down Syndrome / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D005306:Fertilization; D006801:Humans; D008297:Male; D008423:Maternal Age; D008875:Middle Aged; D008957:Models, Genetic; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D011336:Probability; D012641:Selection, Genetic; D014314:Trisomy