Evaluation of the induction of hepatic drug-metabolizing enzymes in the rat and mouse treated with temazepam using trimethadione as the indicator.
In the present paper we report the effect of high doses of temazepam on drug-metabolism induction in rat and mouse. Temazepam induced a dose-dependent and reversible increase of hepatic microsomal drug-metabolizing enzymes in the rat, dose-correlated increase of dimethadione/trimethadione ratios in plasma of the rat, and dose-related shortening of hexobarbital-induced sleeping time in the mouse. In this study trimethadione is considered a good indicator for estimating the state of hepatic enzyme induction.
Kitagawa
Y F
YF
Katahira
M
M
Matsuda
K
K
Tanaka
E
E
Yoshida
T
T
Kuroiwa
Y
Y
D000633:Aminopyrine N-Demethylase / Q000096:biosynthesis; D000815:Aniline Hydroxylase / Q000096:biosynthesis; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D003573:Cytochrome b Group / Q000096:biosynthesis; D015786:Cytochromes b5; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008862:Microsomes, Liver / Q000201:enzymology*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013693:Temazepam / Q000494:pharmacology*; D014293:Trimethadione / Q000097:blood
D014151:Anti-Anxiety Agents; D003573:Cytochrome b Group; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D013693:Temazepam; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase; D014293:Trimethadione; D010634:Phenobarbital