title: [The affinity of aromatic fluoride derivatives of phenothiazine neuroleptics to spiroperidol binding sites of dopamine receptors by the radioligand technic in vitro].
abstract: By introduction of fluorine into the position 7 of butaperazine, chlorpromazine, methoxypromazine, perphenazine, prochlorperazine or into the position 3 of promazine derivatives are obtained with higher affinities for the 3H-spiroperidol binding site of the dopamine receptor compared with the corresponding substances free of fluorine.
authors.forename: W
authors.initials: W
authors.lastname: Oelssner
authors.forename: G
authors.initials: G
authors.lastname: Peinhardt
authors.forename: A
authors.initials: A
authors.lastname: Büge
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D002090:Butyrophenones / Q000378:metabolism*; D006220:Haloperidol / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D010640:Phenothiazines; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism*
chemical_list: D014150:Antipsychotic Agents; D002090:Butyrophenones; D010640:Phenothiazines; D011954:Receptors, Dopamine; D013134:Spiperone; D006220:Haloperidol
vernacular_title: Untersuchungen zur Affinität kernfluorierter Derivate von Phenothiazin-Neuroleptica zur 3H-Spiroperidol-Bindungsstelle des Dopaminrezeptors mittels Radioligandtechnik in vitro.