Increased insulin binding and glucose transport in white adipocytes isolated from C57B1/6 ob/ob mice treated with the thermogenic beta-adrenoceptor agonist BRL 26830.
Obese (ob/ob) mice were treated with the thermogenic beta-adrenoceptor agonist BRL 26830 for 14 days. White adipocytes prepared from these animals showed significant increases in insulin receptor number, with no change in the affinity for these receptors. Increased receptor number was accompanied by increased glucose transport, as measured by 2-deoxyglucose uptake in vitro.
Young
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P
King
L
L
Cawthorne
M A
MA
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D004983:Ethanolamines / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D011972:Receptor, Insulin / Q000187:drug effects
D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D007328:Insulin; C039248:BRL 26830A; D011972:Receptor, Insulin; D005947:Glucose