title: [Glutamate receptor antagonists from the spider Argiope lobata venom].
abstract: Homologous low molecular weight compounds blocking postsynaptic glutamate receptors were isolated from the Argiope lobata spider venom by ion-exchange chromatography and reverse-phase HPLC. Structures of nine different blocking agents were determined by NMR and mass spectroscopy. They can be divided into three groups: argiopin, argiopinins and pseudoargiopinines. The major principles of the structural organization of the novel class of antagonists of glutamate receptors were considered.
authors.forename: E V
authors.initials: EV
authors.lastname: Grishin
authors.forename: T M
authors.initials: TM
authors.lastname: Volkova
authors.forename: A S
authors.initials: AS
authors.lastname: Arsen'ev
mesh_terms: D000596:Amino Acids / Q000032:analysis; D001180:Arthropod Venoms / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D009842:Oligopeptides / Q000302:isolation & purification* / Q000494:pharmacology; D011073:Polyamines / Q000302:isolation & purification* / Q000494:pharmacology; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D013111:Spider Venoms / Q000032:analysis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D001180:Arthropod Venoms; D009842:Oligopeptides; D011073:Polyamines; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D013111:Spider Venoms; C050570:argiopine
vernacular_title: Antagonisty glutamatnykh retseptorov iz iada pauka Argiope lobata.