Gastrin receptors in human gastric scirrhous carcinoma.
Specific binding of 125I-labeled gastrin-17 in tumor tissues and gastric mucosa of 11 advanced human gastric carcinoma cases were studied by single-point receptor assay, using 400 pM 125I-labeled gastrin-17. Membrane preparations (800-15,000 g fraction) of the tissues were examined in this study. In 4 of the 5 cases of gastric scirrhous carcinoma (Borrmann type IV), the tumor tissues showed a high degree of specific bindings (1.1-18.2 femtomoles per milligram protein), but in 5 of the 6 cases of Borrmann type II or III, no specific bindings were detected. These findings indicate that gastrin receptor is frequently present in human gastric scirrhous carcinoma.
Kumamoto
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First Department of Internal Medicine, School of Medicine, Hiroshima University, Japan.
D002293:Adenocarcinoma, Scirrhous / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D011869:Radioligand Assay; D011949:Receptors, Cholecystokinin / Q000032:analysis*; D013274:Stomach Neoplasms / Q000378:metabolism*
D011949:Receptors, Cholecystokinin