Pharmacodynamics of vecuronium, atracurium, tubocurarine and their combinations in the rat in vivo.
In the in vivo rat sciatic nerve tibialis muscle preparation the potency and pharmacodynamics of vecuronium, atracurium, pancuronium, tubocurarine and their combinations were studied. Considering the potency only, there was no beneficial difference between the pure compounds and their combinations. As both vecuronium and atracurium are almost free from side-effects individually, a combination of the two relaxants brings no advantage.
Booij
L H
LH
van Egmond
J
J
van de Pol
F
F
Crul
J F
JF
D000818:Animals; D001279:Atracurium; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D007546:Isoquinolines / Q000008:administration & dosage / Q000494:pharmacology*; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000494:pharmacology*; D010197:Pancuronium / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014403:Tubocurarine / Q000008:administration & dosage / Q000494:pharmacology*; D014673:Vecuronium Bromide
D004338:Drug Combinations; D007546:Isoquinolines; D009466:Neuromuscular Blocking Agents; D001279:Atracurium; D014673:Vecuronium Bromide; D010197:Pancuronium; D014403:Tubocurarine