title: The benzazepine SCH 23390 increases plasma levels of cortisol in the conscious dog.
abstract: The effect of neuroleptics on the hypothalamopituitary-adrenal system has been early recognized, but never adequately related to antipsychotic or side effects produced by dopamine antagonists. We are now presenting results showing that the newly characterized dopamine D-1 receptor antagonist, SCH 23390 (0.1 mg/kg i.v.) as well as the mainly dopamine D-2 receptor antagonists, haloperidol (0.1 mg/kg i.v.) and chlorpromazine (1 mg/kg i.v.), produced an increase of cortisol levels (108, 144 and 226% respectively, 20 min after the injection) determined by radioimmunoassay in blood samples collected from superficial veins of the legs of conscious dogs. The 5-HT2 receptor antagonist, cyproheptadine (0.2 mg/kg i.v.), did not modify the cortisol levels. These results suggest that cortisol increase is an effect common to neuroleptic compounds, independently of their relative antagonistic action at dopamine D-1 or D-2 receptors.
authors.forename: M
authors.initials: M
authors.lastname: Goiny
authors.forename: M
authors.initials: M
authors.lastname: Herrera-Marschitz
authors.forename: K
authors.initials: K
authors.lastname: Uvnäs-Moberg
authors.forename: S
authors.initials: S
authors.lastname: Cekan
authors.forename: U
authors.initials: U
authors.lastname: Ungerstedt
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001552:Benzazepines / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D004285:Dogs; D006220:Haloperidol / Q000494:pharmacology; D006854:Hydrocortisone / Q000097:blood*
chemical_list: D014150:Antipsychotic Agents; D001552:Benzazepines; D003533:Cyproheptadine; D006220:Haloperidol; D002746:Chlorpromazine; D006854:Hydrocortisone