The human Thy-1 gene: structure and chromosomal location.
The human Thy-1 gene has been isolated and sequenced and compared to the rat and mouse Thy-1 genes. All three genes are organized in the same way: one exon encoding the majority of the signal peptide, another encoding the transmembrane segment, and a third encoding the remainder of the protein. One major structural difference between the human and rodent Thy-1 glycoproteins is that the former contains two instead of three glycosylation sites. RNA blot analysis of a human T-cell line expressing the T3 complex showed an absence of Thy-1 mRNA, excluding the possibility that Thy-1 represents one of the component chains of T3. The structural gene for human Thy-1 was localized to the long arm of chromosome 11 by nucleic acid hybridization to genomic DNA isolated from somatic cell hybrids.
Seki
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T
Spurr
N
N
Obata
F
F
Goyert
S
S
Goodfellow
P
P
Silver
J
J
D000595:Amino Acid Sequence; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D001402:B-Lymphocytes / Q000032:analysis; D001483:Base Sequence; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D004274:DNA, Recombinant; D005796:Genes; D006801:Humans; D051379:Mice / Q000235:genetics; D051381:Rats / Q000235:genetics; D011994:Recombinant Proteins / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D004274:DNA, Recombinant; D011994:Recombinant Proteins; D018800:Thy-1 Antigens