title: The effect of glycerol-induced acute renal failure upon cardiac reactivity in the rat: influence of indomethacin treatment and renal pedicle ligation.
abstract: Cardiac chronotropic responses to isoprenaline, carbachol and electrical stimulation of the cervical sympathetic and vagal nerves were recorded in rats with glycerol-induced acute renal failure (ARF) and control rats. The experiments involving electrical stimulation of cardiac nerves were performed in rats which either had been pretreated with indomethacin (1 mg kg-1 twice daily for 2 days) or had undergone acute bilateral renal pedicle ligation. The findings from this investigation indicate that the reduced chronotropic responses to vagal stimulation in rats with glycerol-induced ARF are due to a reduction in acetylcholine release mediated by prostaglandins possibly originating from the damaged kidneys. The diminished response to cervical sympathetic stimulation results from a decreased postsynaptic response to beta-adrenoceptor stimulation.
authors.forename: M S
authors.initials: MS
authors.lastname: Yates
authors.forename: E A
authors.initials: EA
authors.lastname: Askey
authors.forename: S E
authors.initials: SE
authors.lastname: Wilmot
authors.forename: C J
authors.initials: CJ
authors.lastname: Bowmer
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000503:physiopathology*; D000818:Animals; D002217:Carbachol; D005990:Glycerol; D006339:Heart Rate; D007213:Indomethacin; D008297:Male; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000503:physiopathology*
chemical_list: D011453:Prostaglandins; D002217:Carbachol; D005990:Glycerol; D007213:Indomethacin