Effect of rat (beta)-interferon on intracellular levels of hydrolases in rat embryonal fibroblasts (Wistar strain).
The effect of rat beta-interferon (IFN) on the intracellular level of thiole and acid proteases and alkaline phosphatases was investigated. When nontransformed rat embryonal fibroblasts (REF) (Wistar strain) were treated with homologous IFN, a time independent decrease of hydrolase enzyme levels was observed. IFN treatment of transformed cells lead to a time dependent decrease of thiole proteases within 90 min. The values for acid proteases remained unchanged after the short term IFN treatment.
Filipic
B
B
Schauer
P
P
Urh
M
M
Kese
D
D
Likar
M
M
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000201:enzymology; D007370:Interferon Type I / Q000494:pharmacology*; D007700:Kinetics; D010447:Peptide Hydrolases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D007370:Interferon Type I; D000469:Alkaline Phosphatase; D010447:Peptide Hydrolases