title: Multiphase extraction: rapid phase-transfer of [18F]fluoride ion for nucleophilic radiolabeling reactions.
abstract: In multiphase extraction [18F]fluoride ion for radiolabeling is recovered from target water by passage through a small column of microporous polymer impregnated with a lipophilic cryptand or quaternary ammonium salt. The 18O enriched water can be recovered for reuse. The [18F]fluoride ion-pair is eluted from the column by a small volume of acetonitrile or other organic solvent. Evaporation of the acetonitrile removes traces of water to yield a reactive ion pair for nucleophilic radiofluorination reactions. A wide range of ion-pairs based on K+ or NH+4 cryptands or quaternary ammonium salts can be employed. The method was applied to the synthesis of [18F]FDG.
authors.affiliation: Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109-0552.
authors.forename: D M
authors.initials: DM
authors.lastname: Jewett
authors.forename: S A
authors.initials: SA
authors.lastname: Toorongian
authors.forename: G K
authors.initials: GK
authors.lastname: Mulholland
authors.forename: G L
authors.initials: GL
authors.lastname: Watkins
authors.forename: M R
authors.initials: MR
authors.lastname: Kilbourn
mesh_terms: D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000138:chemical synthesis; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D007553:Isotope Labeling / Q000379:methods*
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose