title: Pharmacokinetic and pharmacodynamic interactions between nifedipine and propranolol or betaxolol.
abstract: Pharmacokinetic and pharmacodynamic interactions between nifedipine and two beta-blocking agents were investigated. Eighty mg propranolol twice daily, and 20 mg betaxolol once daily, were randomly administered orally to six young healthy male volunteers, either singly for four days, or combined with nifedipine for the two subsequent days. Nifedipine had similar effects on the pharmacodynamics of both drugs. Nifedipine significantly enhanced propranolol bioavailability and Cmax, but reduced its tmax, in three out of six subjects who were also good absorbers of beta-blockers when taken alone. These effects might be due to enhanced intestinal absorption and/or enhanced first-pass effect, induced by nifedipine.
authors.forename: P
authors.initials: P
authors.lastname: Vinceneux
authors.forename: M
authors.initials: M
authors.lastname: Canal
authors.forename: Y
authors.initials: Y
authors.lastname: Domart
authors.forename: A
authors.initials: A
authors.lastname: Roux
authors.forename: B
authors.initials: B
authors.lastname: Cascio
authors.forename: B
authors.initials: B
authors.lastname: Orofiamma
authors.forename: J
authors.initials: J
authors.lastname: Larribaud
authors.forename: B
authors.initials: B
authors.lastname: Flouvat
authors.forename: C
authors.initials: C
authors.lastname: Carbon
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000097:blood / Q000494:pharmacology*; D000328:Adult; D015784:Betaxolol; D001794:Blood Pressure / Q000187:drug effects; D004347:Drug Interactions; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D011412:Propanolamines / Q000097:blood / Q000494:pharmacology*; D011433:Propranolol / Q000097:blood / Q000494:pharmacology*
chemical_list: D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D011433:Propranolol; D009543:Nifedipine; D015784:Betaxolol