Hepatic biotransformation in the buzzard (Buteo buteo) and the Japanese quail (Coturnix coturnix): effect of PCBs.
Hepatic biotransformation was studied in microsomal (cytochrome P-450-dependent monooxygenase activities) and cytosolic (glutathione S-transferase activities) fractions from Japanese quail (Coturnix coturnix) and buzzard (Buteo buteo). Monooxygenase activities were not very different apart from a high 7-ethoxycoumarin de-ethylase activity in quail as compared to buzzard. Glutathione S-transferase activities were higher in quail than in buzzard. DP5 (a commercial mixture of PCBs containing 50% chlorine) produced a marked increase in monooxygenase activity from quail liver. In contrast, no induction was found in buzzard under the same conditions. Glutathione S-transferase activities were not modified in both species.
Rivière
J L
JL
Grolleau
G
G
Bach
J
J
D000818:Animals; D001717:Birds / Q000378:metabolism*; D003370:Coturnix / Q000378:metabolism*; D003600:Cytosol / Q000201:enzymology; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D011784:Quail / Q000378:metabolism*; D013045:Species Specificity
D011078:Polychlorinated Biphenyls; D006899:Mixed Function Oxygenases; D005982:Glutathione Transferase