Effect of chronic administration of the converting enzyme inhibitor enalapril (MK 421) on brain atrial natriuretic peptide receptors in Wistar-Kyoto and spontaneously hypertensive rats.
Spontaneously hypertensive rats (SHR) showed lower brain ANP binding density when compared with normotensive Wistar-Kyoto (WKY) rats. In the WKY, angiotensin converting enzyme inhibitor, enalapril (25 mg/kg, p.o. for 14 days), decreased the number of ANP binding sites selectively in the subfornical organ and area postrema. Conversely, enalapril increased ANP binding density in the SHR, but only in the area postrema. Enalapril has central effects on ANP binding sites, specific to the circumventricular organs.
Nazarali
A J
AJ
Unit on Preclinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892.
Gutkind
J S
JS
Correa
F M
FM
Saavedra
J M
JM
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004656:Enalapril / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism*; D011919:Rats, Inbred Strains / Q000378:metabolism*; D017461:Receptors, Atrial Natriuretic Factor; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*
D004791:Enzyme Inhibitors; D011956:Receptors, Cell Surface; D004656:Enalapril; D017461:Receptors, Atrial Natriuretic Factor