Graft rejection and graft-versus-host disease: mirror images.
Graft rejection and graft-versus-host disease (GvHD) complicate bone marrow transplantation in animals and man. The likelihood of each correlates with the degree of genetic disparity between donor and recipient. However, instead of a direct relation between graft rejection and GvHD, these events are inversely correlated: in most instances, they are mutually exclusive. A similar, complex relation exists with a third possible event, graft-versus-leukaemia. Attempts to suppress graft rejection or GvHD are likely to increase the reciprocal outcomes unless additional measures are instituted.
Gale
R P
RP
Reisner
Y
Y
D000818:Animals; D016026:Bone Marrow Transplantation; D006084:Graft Rejection; D006086:Graft vs Host Disease / Q000276:immunology* / Q000517:prevention & control; D006680:HLA Antigens / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007165:Immunosuppression Therapy; D007942:Leukemia, Experimental / Q000276:immunology; D008212:Lymphocyte Depletion; D008214:Lymphocytes / Q000276:immunology; D008954:Models, Biological; D012008:Recurrence; D014181:Transplantation Immunology
D006680:HLA Antigens