Effect of H1 blockers alone and in combination with morphine to produce antinociception in mice.
Antinociception was assessed in male CD-1 mice by a modification of Haffner's tail-clamp procedure. The H1 blockers, including an ethylenediamine (pyrilamine), an ethanolamine (diphenhydramine), a phenothiazine (methdilazine), a piperazine (cyclizine) and an alkylamine (chlorpheniramine), all produced antinociception when given alone to mice and also caused potentiation when combined with morphine.
Sun
C L
CL
Hui
F W
FW
Hanig
J P
JP
D000700:Analgesics; D000818:Animals; D002744:Chlorpheniramine / Q000494:pharmacology; D003501:Cyclizine / Q000494:pharmacology; D004155:Diphenhydramine / Q000494:pharmacology; D004357:Drug Synergism; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D010640:Phenothiazines / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology
D000700:Analgesics; D006634:Histamine H1 Antagonists; D010640:Phenothiazines; D002744:Chlorpheniramine; C044642:methdilazine; D009020:Morphine; D004155:Diphenhydramine; D011738:Pyrilamine; D003501:Cyclizine