Cyclic AMP-dependent protein phosphorylation is involved in activation of the potassium current associated with endogenous cellular calcium in Euhadra neurons.
Intracellular injection of the catalytic subunit of cAMP-dependent protein kinase stimulated the outward potassium current associated with endogenous cellular Ca2+ which were abolished by either caffeine or cAMP-dependent protein kinase inhibitor. The principal action of this kinase in current activation may be to release calcium from the intracellular reservoir.
Onozuka
M
M
Department of Anatomy, Gifu University School of Medicine, Japan.
Imai
S
S
Kubo
K
K
Deura
S
S
Nishiyama
K
K
Ozono
S
S
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002122:Calcium Chloride / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D009474:Neurons / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D011494:Protein Kinases / Q000378:metabolism*; D012908:Snails; D012964:Sodium / Q000494:pharmacology
D015221:Potassium Channels; D012964:Sodium; D000242:Cyclic AMP; D011494:Protein Kinases; D002122:Calcium Chloride; D002118:Calcium