[Effect of radiation sterilization on the immunobiological properties of the sorbed protective fraction of Bordetella pertussis].
The possibility of using radiation for the sterilization of the dried preparation of B. pertussis adsorbed protective fraction has been studied. The use of gamma irradiation in a dose of 1.5 X 10(3) J/kg has been found to permit obtaining sterile preparations while preserving their initial protective properties.
Bazhanova
I G
IG
Tsvetkova
N V
NV
Bulk
V F
VF
Mashilova
G M
GM
Lazareva
E S
ES
D000818:Animals; D001886:Bordetella pertussis / Q000276:immunology / Q000528:radiation effects; D004306:Dose-Response Relationship, Immunologic; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000276:immunology / Q000528:radiation effects* / Q000633:toxicity; D013242:Sterilization / Q000379:methods*; D014917:Whooping Cough / Q000517:prevention & control
D010567:Pertussis Vaccine
Izuchenie vliianiia radiatsionnoĭ sterilizatsii na immunobiologicheskie svoĭstva sorbirovannoĭ protektivnoĭ fraktsii kokliushnykh mikrobov.