The uniqueness of superoxide dismutase (SOD)--why cannot most copper compounds substitute SOD in vivo?
It is shown that the copper zinc superoxide dismutase is unique in its ability to catalyze O2- dismutation in vivo in contrast to other copper compounds which have this feature only in vitro. The reasons for this difference are discussed in terms of kinetic and thermodynamic parameters.
Czapski
G
G
Department of Physical Chemistry, Hebrew University of Jerusalem, Israel.
Goldstein
S
S
D002412:Cations; D003300:Copper; D005609:Free Radicals; D013482:Superoxide Dismutase / Q000378:metabolism / Q000627:therapeutic use*; D013481:Superoxides / Q000378:metabolism*
D002412:Cations; D005609:Free Radicals; D013481:Superoxides; D003300:Copper; D013482:Superoxide Dismutase