Effects of serum albumin, indomethacin and histamine H1-antagonists on Paf-acether-induced inflammatory responses in the skin of experimental animals and man.
Cutaneous responses to synthetic platelet activating factor (Paf-acether) have been studied in guinea-pig and human skin. Intradermal injection of Paf-acether elicited an acute inflammatory response in guinea-pig skin (assessed by means of radioisotopic techniques) and acute oedema formation in human skin (assessed by means of weal volume and flare area). Acute inflammatory responses in guinea-pig and human skin are potentiated by the presence of serum albumin, a phospholipid carrier. Acute inflammatory responses induced by Paf-acether in guinea-pig and human skin are not significantly affected by concomitant administration of the cyclo-oxygenase inhibitor, indomethacin. Acute inflammatory responses induced by Paf-acether in guinea-pig and human skin are not significantly affected by concomitant administration of the cyclo-oxygenase inhibitor, indomethacin. Acute inflammatory responses induced by Paf-acether in guinea-pig and human skin are slightly modified by the H1-receptor antagonists, mepyramine and chlorpheniramine. These results indicate that the acute inflammatory response induced by Paf-acether is independent of cyclo-oxygenase products of arachidonic acid and that histamine release has a minor contribution to the inflammatory response induced by Paf-acether.
Archer
C B
CB
MacDonald
D M
DM
Morley
J
J
Page
C P
CP
Paul
W
W
Sanjar
S
S
D000328:Adult; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002744:Chlorpheniramine / Q000494:pharmacology; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced*; D008297:Male; D010972:Platelet Activating Factor / Q000633:toxicity*; D011738:Pyrilamine / Q000494:pharmacology; D012709:Serum Albumin / Q000494:pharmacology*; D012867:Skin / Q000378:metabolism
D001798:Blood Proteins; D006634:Histamine H1 Antagonists; D010972:Platelet Activating Factor; D012709:Serum Albumin; D002744:Chlorpheniramine; D011738:Pyrilamine; D007213:Indomethacin