Valproate as psychotropic agent. Interactions and adverse cerebral reactions.
Recent data stress the psychotropic actions of valproate in schizo-affective disorder. Four patients are reported presenting an altered state of consciousness and prominent EEG dysfunction following combined valproate/neuroleptic drug treatment. Similar cerebral reactions have been reported in anti-epileptic poly- and monotherapy, and the pathogenetic considerations are discussed. Further investigations of the interactions of valproate with other psychotropic agents are highly mandatory.
van Sweden
B
B
van Moffaert
M
M
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003243:Consciousness / Q000187:drug effects; D004347:Drug Interactions; D004569:Electroencephalography; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy; D008875:Middle Aged; D014635:Valproic Acid / Q000009:adverse effects*
D014150:Antipsychotic Agents; D014635:Valproic Acid