title: The reactivation of apodopamine beta-monooxygenase by vanadyl ions.
abstract: Vanadyl ions may be used for reactivation of apodopamine beta-monooxygenase. Maximal activity of the enzyme was achieved at a 350-400-fold molar excess of vanadyl ions, whereas for maximal reconstitution with copper, an 8-10-fold molar excess of copper was necessary. AT higher concentrations of vanadyl as well as of copper, inhibition was observed.
authors.affiliation: Institute of Biochemistry, Academy of Sciences, Armenian SSR, Yerevan, USSR.
authors.forename: K A
authors.initials: KA
authors.lastname: Markossian
authors.forename: N A
authors.initials: NA
authors.lastname: Paitian
authors.forename: R M
authors.initials: RM
authors.lastname: Nalbandyan
mesh_terms: D000313:Adrenal Medulla / Q000201:enzymology*; D000818:Animals; D001051:Apoenzymes / Q000378:metabolism*; D001059:Apoproteins / Q000378:metabolism*; D001665:Binding Sites; D002413:Cations, Divalent; D002417:Cattle; D002837:Chromaffin Granules / Q000201:enzymology*; D002838:Chromaffin System / Q000201:enzymology*; D003300:Copper / Q000378:metabolism / Q000494:pharmacology; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D004789:Enzyme Activation / Q000187:drug effects*; D004793:Enzyme Reactivators; D007700:Kinetics; D046911:Macromolecular Substances; D014638:Vanadates / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D001051:Apoenzymes; D001059:Apoproteins; D002413:Cations, Divalent; D004793:Enzyme Reactivators; D046911:Macromolecular Substances; D014638:Vanadates; D003300:Copper; D004299:Dopamine beta-Hydroxylase