Neurobiological actions of cysteamine.
Somatostatin (SS)-related peptides act within discrete brain regions to inhibit adrenal epinephrine (E) secretion, to prevent hypothermia, and to produce hyperthermia. Depletion of brain concentrations of these SS-related peptides using cysteamine (CSH) or central administration of an SS receptor antagonist increases adrenal E secretion and impairs thermoregulation. These actions of CSH and the SS receptor antagonist are reversed by administration of SS into the central nervous system. These results support the hypothesis that endogenous brain SS-related peptides are involved in the regulation of adrenal E secretion and thermoregulation.
Brown
M
M
Fisher
L
L
Mason
R T
RT
Rivier
J
J
Vale
W
W
D000302:Adrenal Cortex / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001833:Body Temperature Regulation / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D015740:Calcitonin Gene-Related Peptide; D003543:Cysteamine / Q000494:pharmacology*; D015232:Dinoprostone; D004837:Epinephrine / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010446:Peptide Fragments / Q000494:pharmacology; D010455:Peptides / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D013004:Somatostatin / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000494:pharmacology / Q000031:analogs & derivatives; D014667:Vasopressins / Q000378:metabolism
D001786:Blood Glucose; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D010455:Peptides; D011458:Prostaglandins E; C029993:somatostatin-like peptides; D014667:Vasopressins; D013004:Somatostatin; D003543:Cysteamine; C017583:somatostatin, octapeptide-Trp(8)-; D015740:Calcitonin Gene-Related Peptide; D015232:Dinoprostone; D004837:Epinephrine