[In vivo 31 phosphorus spectroscopy of tumors: pre-, intra- and post-therapy].
Using 31P-MR spectroscopy spectra with good signal-to-noise ratio were obtained in five different types of tumours (Ewing's sarcoma, osteosarcoma, malignant melanoma, metastases from a squamous cell carcinoma, parotid adenoma). Surface coils were used. Short- and long-term follow-up after chemotherapy was possible in some cases. In the short-term follow-up, changes in the phosphocreatine and inorganic phosphate resonances could be observed within minutes after the start of the infusion. In the longer follow-ups, changes in phosphodiester and phosphomonoester resonances were observed within two days. There were no significant changes in tissue pH during treatment, but increased pH values were observed in all tumours.
Semmler
W
W
Deutsches Krebsforschungszentrum Heidelberg, Universität Heidelberg.
Gademann
G
G
Bachert-Baumann
P
P
Bier
V
V
Zabel
H J
HJ
Lorenz
W J
WJ
von Kaick
G
G
D000236:Adenoma / Q000175:diagnosis / Q000628:therapy; D000293:Adolescent; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000556:secondary / Q000628:therapy; D002675:Child, Preschool; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000628:therapy; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy; D012516:Osteosarcoma / Q000175:diagnosis / Q000628:therapy; D010307:Parotid Neoplasms / Q000175:diagnosis / Q000628:therapy; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000628:therapy
In vivo 31Phosphor-Spektroskopie von Tumoren: prä-, intra- und posttherapeutisch.