Hypotensive effects after topical and intra-arterial administration of alpha-adrenergic agonists in isolated perfused rabbit eyes.
The influence of nonselective and selective alpha-adrenergic agonists on intraocular pressure (IOP) was studied in isolated arterially perfused rabbit eyes. Drugs were given intra-arterially or topically. With either route of administration, no initial hypertensive phase was observed after l-epinephrine, l-norepinephrine, l-phenylephrine (alpha 1), or methoxamine (alpha 1), but there was an immediate ocular hypotensive effect. The alpha 2-agonist B-HT 920 caused a nonsignificant 1 mm Hg fall in IOP.
van Pinxteren
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D000287:Administration, Topical; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D007269:Injections, Intra-Arterial; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D010477:Perfusion; D010656:Phenylephrine / Q000494:pharmacology; D011817:Rabbits
D000316:Adrenergic alpha-Agonists; D001381:Azepines; D010656:Phenylephrine; C024763:talipexole; D008729:Methoxamine; D004837:Epinephrine