title: High-risk metastatic trophoblastic disease.
abstract: High risk occurs in these patients in two different forms--early and late. Early risks relate to the site and extent of tumors at the start of treatment; late risk is essentially that of drug resistance. Avoidance of drug resistance is the key objective. Central nervous system metastases and placental site trophoblastic tumor require special consideration.
authors.affiliation: Cancer Research Campaign Laboratories, Charing Cross Hospital, London, England.
authors.forename: K D
authors.initials: KD
authors.lastname: Bagshawe
mesh_terms: D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011247:Pregnancy; D012307:Risk Factors; D014328:Trophoblastic Neoplasms / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology*; D014599:Uterus / Q000473:pathology