[Mechanism of the tranquilizing action of electron structural analogs of nicotinamide].
The interaction of nicotinamide and its electron structural analogs (NMF and AzN compounds) with central benzodiazepine receptor antagonist Ro 15-1788 and GABA-ergic system antagonist bicuculline were studied in a conflicting situation test. NMF and AzN behaved as the agonists of GABA-benzodiazepine receptor complex. Like in diazepam, the anxiolytic effects of benzodiazepines and nicotinamide was prevented by bicuculline and Ro 15-1788. The given compounds were shown to be more active, than nicotinamide.
Akhundov
R A
RA
Rozhanets
V V
VV
Voronina
T A
TA
Val'dman
A V
AV
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003220:Conflict, Psychological; D005442:Flumazenil; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D007288:Inosine / Q000494:pharmacology; D008297:Male; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D011869:Radioligand Assay; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D014149:Tranquilizing Agents / Q000494:pharmacology*; D014635:Valproic Acid / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D001570:Benzodiazepinones; D005971:Glutamates; D011963:Receptors, GABA-A; D014149:Tranquilizing Agents; D009536:Niacinamide; D012701:Serotonin; D018698:Glutamic Acid; D005442:Flumazenil; D005680:gamma-Aminobutyric Acid; D007288:Inosine; D014635:Valproic Acid; D001640:Bicuculline
Mekhanizm trankviliziruiushchego deĭstviia nekotorykh élektronno-strukturnykh analogov nikotinamida.