[Effect of N- and M-cholinergic-potentiating and cholinergic-blocking agents on the epileptogenesis of a penicillin focus in the dorsal hippocampus].
Chronic experiments on rabbits with penicillin epilepsy have shown that intravenous injections of the ACHE inhibitor galanthamine (1 mg/kg), and N-cholinergic-blockers, ganglerone (3 mg/kg) and eterofen (8 mg/kg), decreased or suppressed completely epileptogenesis manifestations. Combination of galanthamine with one of the N-cholinergic-blockers markedly increased their anticonvulsive actions. On the contrary, combination of galanthamine with the M-cholinergic-blocker metamizil (0.5 mg/kg) enhanced epileptogenesis activity. It is postulated that both M- and N-cholinergic mechanisms take part in the genesis of penicillin epilepsy. The use of N-cholinergic-blockers and their combinations with M-cholinomimetics as anticonvulsants seems expedient.
Losev
N A
NA
Tkachenko
E I
EI
D000818:Animals; D001535:Benactyzine / Q000031:analogs & derivatives / Q000494:pharmacology; D001565:Benzoates / Q000494:pharmacology; D004158:Diphenylacetic Acids / Q000031:analogs & derivatives / Q000494:pharmacology; D004347:Drug Interactions; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000139:chemically induced*; D005702:Galantamine / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D010277:Parasympathomimetics / Q000494:pharmacology*; D010400:Penicillin G / Q000633:toxicity*; D011817:Rabbits; D011976:Receptors, Muscarinic / Q000187:drug effects*; D011978:Receptors, Nicotinic / Q000187:drug effects*; D013997:Time Factors
D001565:Benzoates; D004158:Diphenylacetic Acids; D010276:Parasympatholytics; D010277:Parasympathomimetics; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D005702:Galantamine; C002675:ethyldiphacil; C008380:metamizil; D001535:Benactyzine; C007824:ganglerone; D010400:Penicillin G
Vliianie N- i M-kholinopotentsiruiushchikh i kholinoblokiruiushchikh sredstv na épileptogenez penitsillinovogo ochaga v dorsal'nom gippokampe.