title: [The effects of heptaminol chlorhydrate on neuromuscular transmission].
abstract: 6-Amino-2-methyl-2-heptanol chlorhydrate, heptaminol chlorhydrate, blocks the response to indirect stimulation of the mouse diaphragm in vitro. This effect is due to a dose-dependent pre- and post-synaptic block of neuromuscular transmission starting at 1 mM heptaminol (HEPT). The complete block of neuromuscular transmission occurs at 10 mM. At 2 mM, the decrease in quantal size is more significant in the presence of d-tubocurarine than when the extracellular calcium is lowered. At this concentration, heptaminol also prolongs the depolarization time of the motor end plate potential. Slightly higher concentrations of heptaminol produce a decrease in quantal content. This latter effect is associated with an increase in synaptic delay.
authors.affiliation: Laboratoire de physiologie générale, Université Paris XII, Créteil, France.
authors.forename: J
authors.initials: J
authors.lastname: Vautrin
authors.forename: J
authors.initials: J
authors.lastname: Mambrini
authors.forename: N
authors.initials: N
authors.lastname: Mauro
authors.forename: C
authors.initials: C
authors.lastname: Quillent
mesh_terms: D000605:Amino Alcohols / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D003964:Diaphragm; D005260:Female; D006535:Heptaminol / Q000494:pharmacology*; D066298:In Vitro Techniques; D051379:Mice; D008815:Mice, Inbred Strains; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects; D014403:Tubocurarine / Q000494:pharmacology
chemical_list: D000605:Amino Alcohols; D006535:Heptaminol; D002118:Calcium; D014403:Tubocurarine
vernacular_title: Effets du chlorhydrate d'heptaminol sur la transmission neuromusculaire.