title: Acyclovir suppression of frequently recurring genital herpes. Efficacy and diminishing need during successive years of treatment.
abstract: Forty-seven patients with frequently recurring genital herpes participated in one or more of five sequential trials of oral suppressive therapy with 200 mg of acyclovir three times daily from four to 12 months' duration. The prolonged use of acyclovir was extremely well tolerated, and treatment efficacy was sustained through successive studies. Recurrences in eight patients with repeated treatment "failures" were more effectively suppressed with higher doses of acyclovir. All patients experienced recurrent infections after the treatments were completed; however, the mean time to recurrence following each treatment period became progressively longer, and resumption of suppressive therapy was no longer warranted for ten patients. These data indicate the efficacy and safety of chronic suppressive therapy with acyclovir and the value of interrupting prolonged treatment to assess its further need.
authors.affiliation: Medical Virology Section, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892.
authors.forename: S E
authors.initials: SE
authors.lastname: Straus
authors.forename: K D
authors.initials: KD
authors.lastname: Croen
authors.forename: M H
authors.initials: MH
authors.lastname: Sawyer
authors.forename: A G
authors.initials: AG
authors.lastname: Freifeld
authors.forename: J M
authors.initials: JM
authors.lastname: Felser
authors.forename: J K
authors.initials: JK
authors.lastname: Dale
authors.forename: H A
authors.initials: HA
authors.lastname: Smith
authors.forename: C
authors.initials: C
authors.lastname: Hallahan
authors.forename: S N
authors.initials: SN
authors.lastname: Lehrman
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D010349:Patient Compliance; D012008:Recurrence; D018139:Simplexvirus / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D000212:Acyclovir