Interpatient variations in antipsychotic therapy.
There is wide interpatient variability not only in therapeutic response to a given dose of antipsychotic drug but also in steady-state plasma levels and the presence and degree of unwanted pharmacologic effects. Such variations have been attributed to individual metabolism, pharmacologic differences, and age--all of which may need careful consideration in prescribing an appropriate dosage regimen for a given patient.
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Gershon
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D000367:Age Factors; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D001480:Basal Ganglia Diseases / Q000139:chemically induced; D002746:Chlorpromazine / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D005476:Fluphenazine / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D001523:Mental Disorders / Q000188:drug therapy* / Q000378:metabolism
D014150:Antipsychotic Agents; D006220:Haloperidol; D005476:Fluphenazine; D002746:Chlorpromazine