Pharmacokinetics of T-2 toxin and its metabolite HT-2 toxin, after intravenous administration in dogs.
The pharmacokinetics of T-2 toxin and HT-2 toxin were investigated comparatively in five dogs, after iv administration of the toxins (0.4 mg/kg). T-2 toxin was very rapidly and almost completely biotransformed to HT-2 toxin (fm = 83.6 +/- 3.9%). The following mean pharmacokinetic parameters were determined in this study for T-2 toxin and HT-2 toxin, respectively: half-life 5.3 +/- 2.1 and 19.6 +/- 4.7 min, clearance 0.107 +/- 0.056 and 0.167 +/- 0.074 liters/min/kg, and volume of distribution 0.86 +/- 0.63 and 4.47 +/- 1.38 liters/kg. The high clearance values suggest that the metabolism of T-2 toxin and HT-2 toxin is carried out in blood and/or through diffusion by nonspecific carboxyesterases. The results of this study suggest the possibility of a sustenance of T-2 toxin metabolism by its binding to blood cells.
Sintov
A
A
Bialer
M
M
Yagen
B
B
D000818:Animals; D001711:Biotransformation; D004285:Dogs; D007275:Injections, Intravenous; D007700:Kinetics; D012717:Sesquiterpenes / Q000378:metabolism*; D013605:T-2 Toxin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*
D012717:Sesquiterpenes; D013605:T-2 Toxin; C012351:HT-2 toxin