Enhancement of monomethylaminoantipyrine-induced increase of hepatic gamma-glutamyltranspeptidase activity by cobaltous chloride in rats.
Co-administration of MAA and CoCl2 enhanced the MAA-induced increase of hepatic microsomal gamma-GTP activity in rats. This may be explained by a fact that inhibition of MAA metabolism in hepatic microsomes by CoCl2 led to increase plasma concentration of MAA which, in turn, induction of gamma-GTP by MAA was potentiated.
Hoshi
K
K
Senda
N
N
Igarashi
T
T
Satoh
T
T
Ueno
K
K
Kitagawa
H
H
D000632:Aminopyrine / Q000031:analogs & derivatives*; D000818:Animals; D003035:Cobalt / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003600:Cytosol / Q000201:enzymology; D004177:Dipyrone / Q000031:analogs & derivatives* / Q000494:pharmacology; D004357:Drug Synergism; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D047069:Pyrazolones; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D047069:Pyrazolones; D000632:Aminopyrine; D003035:Cobalt; D004177:Dipyrone; D003577:Cytochrome P-450 Enzyme System; D005723:gamma-Glutamyltransferase; C018021:cobaltous chloride; C008667:noramidopyrine