[Biotransformation of Chlorphenethazin (Elroquil, Marophen)].
After application of chlorophenethazine more than 20 metabolites were detected in rat urine. The structure of 14 metabolites were elucidated (UV, MS), which are hydroxy, N-dealkyl, S-oxide, sulfone and N-oxid derivatives. The hydroxy derivatives are partly conjugated. The relative high content of the sulfone of 2-chlorophenothiazine-N-acetic acid (upto 10% of the total metabolite content) is remarkable. Main metabolites are the S-oxide of the N-dealkyl derivative and 7-hydroxy-1.
Pfeifer
S
S
Franke
P
P
D000818:Animals; D014150:Antipsychotic Agents / Q000378:metabolism*; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D002746:Chlorpromazine / Q000031:analogs & derivatives* / Q000378:metabolism; D013058:Mass Spectrometry; D051381:Rats; D011919:Rats, Inbred Strains; D013056:Spectrophotometry, Ultraviolet
D014150:Antipsychotic Agents; C002815:chlorfenethazine; D002746:Chlorpromazine
Biotransformation von Chlorphenethazin (Elroquil, Marophen).