[Detection of human papilloma virus (HPV) DNA in vulvar cancers].
Using Southern Blot hybridization 18 invasive malignant tumours of the vulva and 2 intraepithelial vulvar neoplasias were tested for the prevalence of HPV-DNA. In 6 of 11 primary squamous carcinomas, including one carcinoma of the Bartholinic gland, HPV 16 could be identified. Contrarily, in all seven recurrent vulvar tumours examined, including 5 squamous carcinomas, 1 fibrosarcoma and 1 zylindroma, no HPV-DNA was found. No correlation existed between HPV status of the tumours and grade of differentiation or keratinization, or the tumour-stage and lymph-node status. In one tumour-invaded lymph-node HPV 16 was detected as in the corresponding primary tumour. 12 samples from tumour free abdominal skin considered as corresponding normal tissue specimens were negative for HPV-DNA. A correlation between clinical course of the disease and HPV status of the primary tumours was not observed.
Ikenberg
H
H
Universitäts-Frauenklinik Freiburg.
Schwörer
D
D
Pfleiderer
A
A
D001706:Biopsy; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D027383:Papillomaviridae; D011230:Precancerous Conditions / Q000473:pathology*; D014412:Tumor Virus Infections / Q000473:pathology*; D014844:Vulva / Q000473:pathology; D014846:Vulvar Neoplasms / Q000473:pathology*
D004279:DNA, Viral
Nachweis von humaner Papilloma-Virus(HPV)-DNA in Vulvakarzinomen.