Suppression of IgE secretion from hybridoma cells in allotype congenic mice: suppression of allotype 7a by T cells in allotype b mice.
Anti-2,4-dinitrophenyl (DNP) IgE producing hybridoma B 53 when injected subcutaneously is established equally well in syngeneic BALB/c (heavy-chain allotype a) and congenic CB20 (heavy-chain allotype b) mice. However, secretion of anti-DNP IgE monoclonal antibody is greatly suppressed in CB20 mice. B 53 cells taken from the subcutaneous tumors of CB20 mice produce anti-DNP IgE in vivo in BALB/c mice and in vitro. No difference was observed in IgE production between these cells and the controls taken from BALB/c mice. The suppression of IgE production was due to T cells and/or their product(s) of CB20 mice.
Maekawa
S
S
de Szalay
C
C
Ovary
Z
Z
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology; D004140:Dinitrophenols / Q000276:immunology; D006825:Hybridomas / Q000378:metabolism*; D007108:Immune Tolerance; D007126:Immunoglobulin Allotypes / Q000276:immunology*; D007073:Immunoglobulin E / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D004140:Dinitrophenols; D007126:Immunoglobulin Allotypes; D018800:Thy-1 Antigens; D007073:Immunoglobulin E