title: Variable infectivity of third-stage larvae of Brugia malayi.
abstract: Infectivity of third-stage larvae of Brugia malayi was assessed following intraperitoneal inoculation into jirds, Meriones unguiculatus. Larvae were of two ages and were derived from two sites in Aedes aegypti mosquitoes, i.e., specimens collected from the thorax 11 days after infection and from the head on day 14. Larvae from the thorax had just completed the second moult and measured 990 to 1100 micron in length. Only 6% of these specimens developed to adult worms in jirds. Larvae that migrated to the head were 1400 to 1700 micron long on day 14 and, in contrast, 23% of the inocula developed to adult worms. This study establishes that all third-stage larvae, regardless of their age or location in the arthropod host, are potentially infective. However, pronounced physical maturation does seem to be accompanied by a marked increase in infectivity.
authors.forename: M L
authors.initials: ML
authors.lastname: Eberhard
authors.forename: R C
authors.initials: RC
authors.lastname: Lowrie
mesh_terms: D000818:Animals; D002009:Brugia / Q000254:growth & development / Q000472:pathogenicity*; D009033:Culicidae / Q000469:parasitology; D005260:Female; D005849:Gerbillinae; D007814:Larva