Preferential effectiveness of cyclosporin in patients receiving kidney transplants after glomerulonephritis.
Glomerulonephritis patients transplanted with cadaver kidneys had a significantly higher one-year graft survival when immunosuppressed with cyclosporin rather than standard therapy (80% versus 59%, p less than 10(-5]. For nephrosclerosis patients the corresponding rates were 70% and 59% (p greater than 0.05); and in those with antecedent diabetes mellitus, polycystic kidney, and pyelonephritis the differences were negligible. In glomerulonephritis patients, but not in the other groups, cyclosporin was additive to the effect of transfusions and of HLA-A, B and HLA-Dr matching.
Cats
S
S
Terasaki
P I
PI
Perdue
S
S
Mickey
M R
MR
D003524:Cyclosporins / Q000627:therapeutic use*; D005921:Glomerulonephritis / Q000150:complications*; D006085:Graft Survival / Q000187:drug effects*; D006680:HLA Antigens / Q000032:analysis; D006648:Histocompatibility; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery*; D016030:Kidney Transplantation; D009400:Nephrosclerosis / Q000150:complications
D003524:Cyclosporins; D006680:HLA Antigens