Cardiovascular and renal effects of buspirone in several animal models.
Intravenous administration (0.3 or 3 mg/kg) of buspirone to anesthetized rats elicited a transient pressor response (14 +/- 2 mmHg) and sustained bradycardia. However, oral administration (30 mg/kg) reduced the blood pressure and heart rate of conscious normotensive (-14 +/- 4 mmHg) and DOCA-salt hypertensive rats (-22 +/- 5 mmHg). Buspirone (3-100 mg/kg, p.o.) elicited increases in urinary volume and electrolyte excretion of conscious normotensive rats and decreased these parameters in conscious mice. Buspirone was observed to possess alpha 1-adrenoceptor agonist activity in ganglion-blocked anesthetized rats. Buspirone (0.3-3 mg/kg, i.v.) elicited transient elevations in the blood pressure of open-chest anesthetized dogs. There was a sustained increase in total peripheral resistance and a decrease in aortic blood flow, heart rate, right ventricular contractile force and left ventricular dp/dt max. Intravenous and oral administration to anesthetized and conscious dogs elevated urinary volume and electrolyte excretion. However, the doses used to elicit the observed alterations in hemodynamic/renal function are considerably greater than those which produce anxiolytic effects. Thus, it is doubtful that anxiolytic doses of buspirone will produce cardiovascular alterations in patients.
Hanson
R C
RC
Braselton
J P
JP
Hayes
D C
DC
Snyder
R W
RW
White
J B
JB
Deitchman
D
D
D000758:Anesthesia; D000818:Animals; D014151:Anti-Anxiety Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000959:Antihypertensive Agents; D002065:Buspirone; D004231:Diuresis / Q000187:drug effects*; D004285:Dogs; D004558:Electric Stimulation; D004573:Electrolytes / Q000652:urine; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D051379:Mice; D009318:Natriuresis / Q000187:drug effects; D011743:Pyrimidines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013233:Stellate Ganglion / Q000502:physiology
D014151:Anti-Anxiety Agents; D000959:Antihypertensive Agents; D004573:Electrolytes; D011743:Pyrimidines; D002065:Buspirone