title: Immunohistochemical localization of Na+, K+-ATPase in the human endolymphatic sac.
abstract: The presence and distribution of the transport protein complex Na+,K+-ATPase in the human endolymphatic sac (ES) was demonstrated immunohistochemically using a monoclonal antibody directed toward the denatured catalytic subunit of Na+,K+-ATPase from lamb kidney medulla. Our findings support an active transcellular ion exchange by the ES epithelium with subsequent passive transcellular and paracellular outflow of water. The possible role of the lateral intercellular spaces in the outflow of endolymph at the level of the ES is discussed.
authors.affiliation: Division of Head and Neck Surgery, UCLA School of Medicine.
authors.forename: P A
authors.initials: PA
authors.lastname: Wackym
authors.forename: M E
authors.initials: ME
authors.lastname: Glasscock
authors.forename: F H
authors.initials: FH
authors.lastname: Linthicum
authors.forename: U
authors.initials: U
authors.lastname: Friberg
authors.forename: H
authors.initials: H
authors.lastname: Rask-Andersen
mesh_terms: D000911:Antibodies, Monoclonal; D007758:Ear, Inner / Q000201:enzymology*; D004712:Endolymphatic Sac / Q000201:enzymology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007474:Ion Exchange; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D000254:Sodium-Potassium-Exchanging ATPase