title: Renal tolerance of ofloxacin, a new gyrase inhibitor.
abstract: An open study was carried out in 12 male, healthy volunteers to investigate the renal tolerance of ofloxacin, a new, broad-spectrum oral antibacterial agent. Subjects received single doses of 300 mg and then repeated doses of 300 mg ofloxacin twice daily for 7 days. Urine was collected in several fractions during the study and the excretion of creatinine, alanine-aminopeptidase (AAP), gamma-glutamyl transferase (GGT) and n-acetyl-beta-glucose aminidase (NAG) was calculated in 12-hour fractions. Serum creatinine, beta 2-microglobulin concentrations and creatinine clearance were also determined. Based on the findings for the kidney enzymes AAP, GGT and NAG, renal tolerance was good. This was confirmed by creatinine clearance and serum beta 2-microglobulin values. Ofloxacin showed no nephrotoxic potential in this study.
authors.forename: M
authors.initials: M
authors.lastname: Verho
authors.forename: E E
authors.initials: EE
authors.lastname: Dagrosa
authors.forename: P
authors.initials: P
authors.lastname: Usinger
authors.forename: H
authors.initials: H
authors.lastname: Grötsch
authors.forename: V
authors.initials: V
authors.lastname: Malerczyk
authors.forename: M
authors.initials: M
authors.lastname: Uchida
authors.forename: R
authors.initials: R
authors.lastname: Rangoonwala
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D000410:Alanine Transaminase / Q000652:urine; D000890:Anti-Infective Agents / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin; D010078:Oxazines / Q000009:adverse effects*; D013997:Time Factors; D059005:Topoisomerase II Inhibitors; D001613:beta 2-Microglobulin / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000652:urine
chemical_list: D000890:Anti-Infective Agents; D010078:Oxazines; D059005:Topoisomerase II Inhibitors; D001613:beta 2-Microglobulin; D015242:Ofloxacin; D003404:Creatinine; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase; D000118:Acetylglucosaminidase