[Role of dopamine receptors in the mechanism of action of neuroleptics].
The authors analyze the literature and their own data on the influence of neuroleptics on the cerebral dopamine and adrenoreceptors. It is shown that antipsychotic activity of neuroleptics correlates with their ability to block D2 dopamine receptor whereas their sedative properties are in a better agreement with the blockade of alpha 1-adrenoreceptor. Effects at the molecular level, other than the blockade of the above receptors, may be involved in forming the activity spectrum of each drug.
Lavretskaia
E F
EF
Kats
M M
MM
Baldenkov
G N
GN
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D001921:Brain / Q000187:drug effects*; D002090:Butyrophenones; D006634:Histamine H1 Antagonists; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D051379:Mice; D010640:Phenothiazines; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D017981:Receptors, Neurotransmitter / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D002090:Butyrophenones; D006634:Histamine H1 Antagonists; D006993:Hypnotics and Sedatives; D010640:Phenothiazines; D011942:Receptors, Adrenergic, alpha; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D017981:Receptors, Neurotransmitter; D001569:Benzodiazepines
O roli dofaminovykh retseptorov v mekhanizmakh deĭstviia neĭroleptikov.