[Microfluorimetric study of the effect of almitrine bismesylate (Vectarion) on intrapulmonary neuroepithelial bodies].
As Almitrine bismesylate is a potent peripheral chemo-receptor stimulant we have studied its action, after intra-peritoneal injection, on the intra-neuro-epithelial bodies (NEB) of 24 young rabbits (4 to 17 days old) measuring the intensity of the cytoplasmic fluorescence. The administration of Almitrine bismesylate in pharmacological doses provoked a marked rise (around 25%) in the intensity of fluorescence of NEB compared to a placebo group, indicating a raised cytoplasmic concentration of serotonin. These observations show that Almitrine bismesylate, in stimulating all the peripheral chemo-receptors equally, influences the NEB at the same time corroborating the intra-pulmonary chemoreceptor mature of the latter. The mechanism of action of Almitrine bismesylate on the NEB remains unexplained at a cellular level. Some supplementary studies are planned to elucidate these aspects.
Lauweryns
J M
JM
van Lommel
A
A
van Meerbeek
J
J
D015765:Almitrine; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D008168:Lung / Q000294:innervation*; D010879:Piperazines / Q000494:pharmacology*; D011817:Rabbits; D011984:Sensory Receptor Cells / Q000187:drug effects* / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
D000697:Central Nervous System Stimulants; D010879:Piperazines; D012701:Serotonin; D015765:Almitrine
Etude microfluorimétrique de l'action du bismésilate d'almitrine (Vectarion) sur les corps neuro-épithéliaux intrapulmonaires.