title: A retrospective study of aldosterone secretion in normal and adrenopathic dogs.
abstract: A retrospective study on stored plasma from normal dogs and dogs with pituitary dependent hyperadrenocorticism (PDH), pituitary dependent hyperadrenocorticism controlled by mitotane (o,p'-DDD),* iatrogenic hyperadrenocorticism, and hypoadrenocorticism was conducted to determine if alterations in aldosterone production exist in these disorders. The plasma aldosterone concentration (PAC) was measured by radioimmunoassay immediately before and 1 hour after adrenocorticotropic hormone (ACTH) administration (0.5 IU/kg, intravenously [IV]). PACs increased significantly when ACTH was administered to normal dogs. Dogs with PDH had a lower baseline PAC, but their PAC increased to levels similar to that of normal dogs after ACTH administration. In dogs with PDH controlled by o,p'-DDD therapy, the response to ACTH was significantly less than that of normal dogs or dogs with untreated PDH. Dogs with iatrogenic hyperadrenocorticism had a lower baseline and post-ACTH PAC than normal dogs. Dogs with hypoadrenocorticism had a normal basal PAC, but showed no significant increase in PAC following ACTH administration. These findings suggest that PACs are significantly altered in a variety of adrenal diseases, and that the ACTH stimulation test may be useful when evaluating aldosterone secretion in adrenopathic disorders. In addition, at therapeutic dosages, o,p'-DDD treatment was associated with a decrease in basal and post-ACTH PACs in dogs with PDH.
authors.affiliation: Department of Urban Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901.
authors.forename: D L
authors.initials: DL
authors.lastname: Golden
authors.forename: C D
authors.initials: CD
authors.lastname: Lothrop
mesh_terms: D000302:Adrenal Cortex / Q000378:metabolism; D000303:Adrenal Cortex Diseases / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone; D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D004283:Dog Diseases / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D008939:Mitotane / Q000627:therapeutic use; D012189:Retrospective Studies
chemical_list: D000450:Aldosterone; D008939:Mitotane; D000324:Adrenocorticotropic Hormone