Evidence for an adrenal contribution to plasma digitalis-like factors.
Digitalis-like factors (DLF) were assayed on plasma collected serially using antibody to digoxin: (1) after intravenous ACTH (n = 3 patients) and (2) after 0.15 U/kg crystalline insulin, 50 micrograms gonadotropin-releasing hormone and 0.2 mg thyrotropin-releasing hormone (n = 7) as a combined pituitary function test. Patients had either hypothalamic-pituitary or ovarian problems. Mean values for DLF rose fourfold after ACTH, and by a factor of 2.3 with the combined pituitary function test. DLF rose at least 50% in all 10 subjects. In 3 dogs, adrenal vein values for DLF were on average more than double values in either adrenal artery or lower vena cava. These results suggest that certain DLFs have an adrenal origin.
Gault
M H
MH
Department of Medicine, General Hospital, St. John's, Nfld., Canada.
Vasdev
S
S
Longerich
L
L
Johnson
E
E
Farid
N
N
Legal
Y
Y
Prabhakaran
V
V
Fine
A
A
D000311:Adrenal Glands / Q000502:physiology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000328:Adult; D000818:Animals; D001798:Blood Proteins / Q000097:blood*; D002298:Cardenolides; D004077:Digoxin / Q000276:immunology; D004285:Dogs; D005260:Female; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D012503:Saponins; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D001798:Blood Proteins; D002298:Cardenolides; D007328:Insulin; D012503:Saponins; C034504:digoxin-like factors; D013973:Thyrotropin-Releasing Hormone; D004077:Digoxin; D000324:Adrenocorticotropic Hormone