Placental plasminogen activator activity in pre-eclampsia.
Plasminogen activator is one of the principal enzymes involved in the fibrinolytic system. The plasminogen activator activity in placental tissue was examined using a chromogenic substrate in 9 patients with pre-eclampsia and in 9 women with uncomplicated pregnancy, who were delivered between 37 and 42 weeks of gestation. In the patients with pre-eclampsia, the plasminogen activator activity was significantly (P less than 0.05) decreased compared with that in the control group of normal pregnant women. The present findings suggest a decreased fibrinolytic activity in the placental tissue of pre-eclamptic patients, which is responsible for fibrin deposition in the placental tissue and may contribute to placental ischemia and insufficiency in pre-eclampsia.
Yoshimura
T
T
Yamashita
J
J
Ito
M
M
Matsui
K
K
Maeyama
M
M
D000328:Adult; D001724:Birth Weight; D005260:Female; D005865:Gestational Age; D006801:Humans; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology / Q000201:enzymology*; D010960:Plasminogen Activators / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
D010960:Plasminogen Activators