title: Alpha-2 adrenergic receptor binding in platelets and brains of nervous and normal pointer dogs.
abstract: Nervous pointer dogs have been suggested as an animal model for certain human pathological anxiety states. Work done in humans and in animals suggests a role for noradrenergic overactivity in the manifestations of anxiety. We studied alpha 2 adrenergic receptor binding as determined by [3H]-yohimbine in platelets and brains of the nervous and normal dogs in our colony. Our findings indicate that alpha 2 adrenergic receptor density and affinity are similar in platelets and frontal cortex, but we did not observe significant differences in binding between the two groups of dogs.
authors.affiliation: Unit on Anxiety and Affective Disorders, NIMH, Bethesda, MD 20205.
authors.forename: E
authors.initials: E
authors.lastname: Klein
authors.forename: R H
authors.initials: RH
authors.lastname: Lenox
authors.forename: T W
authors.initials: TW
authors.lastname: Uhde
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology*; D001792:Blood Platelets / Q000378:metabolism*; D001921:Brain / Q000502:physiology*; D004285:Dogs; D005625:Frontal Lobe / Q000502:physiology; D011941:Receptors, Adrenergic / Q000502:physiology*; D013045:Species Specificity; D015016:Yohimbine / Q000493:pharmacokinetics*
chemical_list: D011941:Receptors, Adrenergic; D015016:Yohimbine