Effects of theophylline and salbutamol on phosphate and calcium metabolism in normal subjects.
The acute effects of oral theophylline and salbutamol were studied in a randomised double-blind crossover study in 12 normal subjects. Theophylline resulted in a significant fall in plasma phosphate and a small rise in urine phosphate excretion which did not, however, account for the fall in plasma phosphate. The increase in urine phosphate excretion was accompanied by a rise in sodium, calcium and water excretion. These changes were not accompanied by a change in renal cyclic AMP production, plasma parathyroid hormone levels or plasma calcitonin levels. Salbutamol had only minor effects on urine calcium and phosphate excretion.
Prince
R L
RL
Department of Medicine, University of Western Australia.
Monk
K J
KJ
Kent
G N
GN
Dick
I
I
Thompson
P J
PJ
D000328:Adult; D000368:Aged; D000420:Albuterol / Q000494:pharmacology*; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D000242:Cyclic AMP / Q000378:metabolism; D004231:Diuresis / Q000187:drug effects; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood / Q000378:metabolism* / Q000652:urine; D013806:Theophylline / Q000494:pharmacology*
D010281:Parathyroid Hormone; D010710:Phosphates; D002116:Calcitonin; D013806:Theophylline; D000242:Cyclic AMP; D000420:Albuterol; D002118:Calcium