Production of insulin-like growth factor binding protein(s) (IGF-BPs) by human placenta: variation with gestational age.
Preterm human placentae produce insulin-like growth factor- (IGF-)specific binding protein(s). Competitive binding experiments revealed at least two distinct, high-affinity binding sites for IGF-I and IGF-II. Gel permeation chromatography and sodium dodecyl sulphate-polyacrylamide gel electrophoresis analysis of the binding protein(s) suggested that they possess a molecular weight in the 45 to 50 kD range. In contrast, term placental tissue produced almost no detectable binding protein activity.
Fant
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Department of Pediatrics, Harvard Medical School, Boston, MA.
Munro
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H
Moses
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AC
D003513:Cycloheximide / Q000494:pharmacology; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008970:Molecular Weight; D009924:Organ Culture Techniques; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism*; D017451:Receptors, Somatomedin; D013002:Somatomedins / Q000378:metabolism*
D011956:Receptors, Cell Surface; D017451:Receptors, Somatomedin; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D003513:Cycloheximide