Radiolabeled blood cells: techniques and applications.
During the past few years, the clinical and experimental applications of autologous blood cells labeled with gamma-emitting radionuclides, i.e., technetium-99m (Tc-99m) and indium-111 (In-111) have continued to grow rapidly. Investigations have centered around developing techniques that would label blood cells efficiently without alteration of cell viability and their pathophysiologic integrity. Experimental and clinical applications have been aimed at the studies of in vivo cell kinetics and detecting abnormal lesions by external imaging. These will be discussed in detail together with their advantages and disadvantages, and the future directions will be outlined.
Desai
A G
AG
Department of Radiation Therapy and Nuclear Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.
Thakur
M L
ML
D001792:Blood Platelets; D002860:Chromium Radioisotopes; D004912:Erythrocytes; D006801:Humans; D007205:Indium Radioisotopes; D007504:Iron Radioisotopes; D007962:Leukocytes; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m
D002860:Chromium Radioisotopes; D007205:Indium Radioisotopes; D007504:Iron Radioisotopes; D013670:Sodium Pertechnetate Tc 99m