The role of macrophages in adenovirus-induced immunosuppression in mice.
A decreased humoral immune response to sheep red blood cells (SRBC) was demonstrated in CFLP mice inoculated with human adenovirus type 6 (Ad6 virus). The suppressive effect depended on the inoculation sites of the virus and SRBC. Inoculation by the same route, i.e. intraperitoneally (i.p.), resulted in a significant decrease of the humoral immune response to SRBC. When administering the virus and SRBC at different sites, no inhibitory effect could be detected. Immunosuppression was prevented by pretreatment of mice with silica depressing the macrophage function. The results indicate that peritoneal macrophages play an important role in the immunosuppression observed.
Berencsi
K
K
Bakay
M
M
Béládi
I
I
D000257:Adenoviridae Infections / Q000276:immunology*; D000258:Adenovirus Infections, Human / Q000276:immunology*; D000818:Animals; D007108:Immune Tolerance; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice