Predominance of histamine H1 receptors on liver plasma membrane.
We quantitatively determined the receptors for histamine H1, histamine H2, alpha- and beta-adrenergic, prostaglandin E2 and F2 alpha in liver plasma membranes. The number of the receptors was the greatest in histamine H1 receptors (4740 +/- 750 fmol/mg protein) and the second in alpha-adrenergic receptors (965 +/- 16). Although relatively small numbers of the receptors were observed for histamine H2 (116 +/- 11) and prostaglandin E2 (38.0 +/- 8.9), we could not determine the number and affinity of beta-adrenergic and prostaglandin F2 alpha receptors. In contrast to the number of receptors, there was not significant difference in the affinities of receptors for histamine H1, histamine H2, alpha-adrenergic hormone and prostaglandin E2. These results suggest that histamine and its receptor play some role in liver function.
Imoto
M
M
Tsuchie
K
K
Tanaka
M
M
Sugiyama
S
S
Ozawa
T
T
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004088:Dihydroergotoxine / Q000378:metabolism; D015232:Dinoprostone; D006632:Histamine / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D011458:Prostaglandins E / Q000378:metabolism; D011738:Pyrilamine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011968:Receptors, Histamine / Q000378:metabolism*; D011969:Receptors, Histamine H1 / Q000378:metabolism*; D011982:Receptors, Prostaglandin / Q000378:metabolism; D018078:Receptors, Prostaglandin E
D011458:Prostaglandins E; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011982:Receptors, Prostaglandin; D018078:Receptors, Prostaglandin E; C034671:prostaglandin F2alpha receptor; D004088:Dihydroergotoxine; D006632:Histamine; D011738:Pyrilamine; D015232:Dinoprostone