title: Cholinergic involvement in the modulation of oxotremorine-tremor in mice by propranolol.
abstract: Propranolol in low doses antagonized and in higher doses facilitated oxotremorine-induced tremor (Oxo-tremor) in mice. Atropine blocked Oxo-tremor, an effect that was reversed by propranolol. Atropine pretreatment also antagonized the potentiating effect of propranolol on Oxo-tremor. Propranolol inhibited mice brain cholinesterase at doses which enhanced Oxo-tremor. Timolol and sotalol produced a dose-dependent antagonism of Oxo-tremor, whereas practolol failed to produce a similar effect. None of these three agents produced any significant enhancement of Oxo-tremor. These results suggest the involvement of a peripheral mechanism for the antagonism and a central cholinergic mechanism for the facilitation of Oxo-tremor by propranolol.
authors.forename: M
authors.initials: M
authors.lastname: Alkondon
authors.forename: A
authors.initials: A
authors.lastname: Ray
authors.forename: P
authors.initials: P
authors.lastname: Sen
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007531:Isoflurophate / Q000494:pharmacology; D008297:Male; D051379:Mice; D010095:Oxotremorine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D014202:Tremor / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D000319:Adrenergic beta-Antagonists; D002800:Cholinesterase Inhibitors; D007531:Isoflurophate; D010095:Oxotremorine; D001285:Atropine; D011433:Propranolol