title: [Directed synthesis of 2',5'-oligoadenylates with increased stability towards phosphodiesterases].
abstract: Phosphodiesterase stability of synthetic analogs of 2',5'-oligoadenylates, the mediators of antiviral and antiproliferative action of interferons was analysed. The analogs with a 3'-terminal acyclic nucleoside residue were prepared. These analogs were treated with NIH3T3 cell lysate, mice liver homogenate and snake venom phosphodiesterase. All analogs have demonstrated a high stability as compared with the natural 2',5'-oligoadenylate and its 3'-deoxyderivative. The possible biological activity of these stable analogs of 2',5'-oligoadenylates is discussed.
authors.forename: A V
authors.initials: AV
authors.lastname: Itkes
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Karpeĭskiĭ
authors.forename: O N
authors.initials: ON
authors.lastname: Kartasheva
authors.forename: S N
authors.initials: SN
authors.lastname: Mikhaĭlov
authors.forename: G P
authors.initials: GP
authors.lastname: Moiseev
mesh_terms: D000227:Adenine Nucleotides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D051379:Mice; D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*
chemical_list: D000227:Adenine Nucleotides; D009843:Oligoribonucleotides; C023505:2',5'-oligoadenylate; D010727:Phosphoric Diester Hydrolases
vernacular_title: Napravlennoe sozdanie 2',5'-oligoadenilatov s povyshennoĭ ustoĭchivost'iu k fosfodiésterazam.