title: Clonidine accelerates growth in children with impaired growth hormone secretion.
abstract: 4 children with isolated growth hormone deficiency (IGHD) and 4 with constitutional growth delay (CGD) were treated with clonidine, 0.1 mg/m2 daily, for 60 days. In 2 children with IGHD and all 4 with CGD, basal growth hormone (GH) and somatomedin-C levels were increased, pituitary GH response to challenges with a synthetic pancreatic GH releasing factor and clonidine was enhanced, and linear growth was stimulated.
authors.forename: C
authors.initials: C
authors.lastname: Pintor
authors.forename: S G
authors.initials: SG
authors.lastname: Cella
authors.forename: R
authors.initials: R
authors.lastname: Corda
authors.forename: V
authors.initials: V
authors.lastname: Locatelli
authors.forename: R
authors.initials: R
authors.lastname: Puggioni
authors.forename: S
authors.initials: S
authors.lastname: Loche
authors.forename: E E
authors.initials: EE
authors.lastname: Müller
mesh_terms: D002648:Child; D003000:Clonidine / Q000627:therapeutic use*; D005260:Female; D006130:Growth Disorders / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D013006:Growth Hormone / Q000172:deficiency* / Q000378:metabolism; D013007:Growth Hormone-Releasing Hormone; D006801:Humans; D007334:Insulin-Like Growth Factor I; D008297:Male; D013002:Somatomedins / Q000097:blood
chemical_list: D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D003000:Clonidine