title: [Myocardial mechanical injury in acute ischemia: a pathophysiologic and histopathologic review].
abstract: The recognition of histopathologic substrates of myocardial contractile damage in human acute ischemia is still very poor, notwithstanding the impressive advances in the inherent clinical diagnostic technology and concepts. The first and foremost inotropic abnormality ensuing ischemia, easily taken for atonic in origin, actually consists of a pathologic contracture of the injured myocardium, depending upon abrupt fall of ATP, and defective extrusion calcium pump with persistence of actomyosin rigor-complexes. In sustained ischemia, further membrane damage exposes the myocell to massive calcium intrusion, with eventual precipitation of it and cell death (reperfusion stone-heart). In case of transient, "hit and run" ischemia, the "stunned" myocardium undergoes prolonged contractile abnormalities. In keeping with fundamentals in pathophysiology of contraction, ischemic myofibrils in human hyperacute infarct, showed spare I bands, accounting for contracture and followed by loss of the regular cross-striation register; then, groups of adjacent sarcomeres were seen to join into true "contraction" bands, with Z lines impinging upon A bands and obliterating the I bands. Coagulative denaturation of contractile proteins follows, presenting as irregular, amorphous degeneration stripes astride irreversibly damaged myocells. As such, these cells can be passively overstretched by the nearby functioning muscle. In turn, the fixed waviness of viable, acutely ischemic myocardium was thought to configure, histologically, the loss of ATP-dependent "plasticity" of myofilaments, in a state of contracture. The "relaxant effect" of inotropic-chronotropic-positive catecholamines, favoring diastole, has been also pointed out. The present microscopic findings are cogent to clinicopathologic problems of coronary ischemia-reperfusion, and sudden death from cardiogenic shock.
authors.forename: L
authors.initials: L
authors.lastname: Rossi
authors.forename: L
authors.initials: L
authors.lastname: Matturri
mesh_terms: D000255:Adenosine Triphosphate / Q000502:physiology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D002118:Calcium / Q000502:physiology; D002395:Catecholamines / Q000502:physiology; D003327:Coronary Disease / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D000255:Adenosine Triphosphate; D002118:Calcium
vernacular_title: II danno meccanico miocardico nell'ischemia acuta: una sintesi patofisiologica ed istopatologica.