Regional ontogenetic profile of central and peripheral benzodiazepine receptors in the guinea pig brain.
The ontogenetic development of 'central' and 'peripheral' benzodiazepine (BZ) receptors was investigated in 3 different regions of the guinea pig brain. A marked difference in the developmental profile of these two types of binding sites was observed. The density of central-type receptors gradually increased during embryonic life (especially in cortex and cerebellum), without major changes after birth, while the reverse was true for peripheral-type binding sites. These data contrast with those previously reported in rat, suggesting species differences.
Daval
J L
JL
Unit on Neurochemistry, National Institute of Mental Health, Bethesda, MD 20892.
Deckert
J
J
Nakajima
T
T
Morgan
P F
PF
Marangos
P J
PJ
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001570:Benzodiazepinones / Q000378:metabolism; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D005442:Flumazenil / Q000378:metabolism; D006168:Guinea Pigs; D011963:Receptors, GABA-A / Q000378:metabolism* / Q000502:physiology
D001570:Benzodiazepinones; D011963:Receptors, GABA-A; C028513:4'-chlorodiazepam; D005442:Flumazenil