Three-year prospective study of the evolution of Manson's schistosomiasis in north-east Brazil.
A cross-sectional study of morbidity associated with Schistosoma mansoni infection in an area in North-East Brazil where the disease is endemic was carried out in 1974. The survey was repeated in 1977, before mass treatment with oxamniquine, providing a cohort of 210 individuals who had both examinations. The high prevalence of hepatomegaly (over 80%) and of splenomegaly (over 15%) contrasted with rates of 10% and 1%, respectively, in a non-endemic area. Over the 3-year period hepatomegaly spontaneously regressed in 13% of patients, and splenomegaly regressed in 56%, a phenomenon most common in older individuals with light infections. Those with heavy infections--ie, 500 or more eggs per g faeces, had an excess risk of splenomegaly of 19.6% and, of its persistence, of 61.5%. Thus, intensity of infection was a critical factor in liver and spleen involvement, and programmes of chemotherapy that reduce infection should mitigate the risk of schistosomal morbidity.
Sleigh
A C
AC
Mott
K E
KE
Hoff
R
R
Barreto
M L
ML
Mota
E A
EA
Maguire
J H
JH
Sherlock
I
I
Weller
T H
TH
D000293:Adolescent; D000328:Adult; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D006529:Hepatomegaly / Q000209:etiology / Q000473:pathology; D006801:Humans; D010073:Oxamniquine / Q000627:therapeutic use; D011446:Prospective Studies; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology; D013163:Splenomegaly / Q000209:etiology / Q000473:pathology
D010073:Oxamniquine