Ventricular somatostatin-like immunoreactivity in patients with basal ganglia disease.
The concentrations of somatostatin-like immunoreactivity (SLI) in lateral ventricular fluid of patients with extrapyramidal motor disease were determined by specific radio-immunoassay. Mean SLI levels were significantly lower in patients with Parkinson's disease (mean +/- SEM); 42.9 +/- 2.9 fmol/ml) and in patients with dystonic syndromes (39.4 +/- 3.2) than in patients with benign essential tremor (65.3 +/- 9.7). The lowest levels were found in patients with athetosis (34.7 +/- 5.4). In parkinsonian patients somatostatin levels correlated with the degree of akinesia, rigidity and autonomic disturbances.
Cramer
H
H
Wolf
A
A
Rissler
K
K
Weigel
K
K
Ostertag
C
C
D000328:Adult; D001264:Athetosis / Q000134:cerebrospinal fluid; D001342:Autonomic Nervous System Diseases / Q000134:cerebrospinal fluid; D001480:Basal Ganglia Diseases / Q000134:cerebrospinal fluid*; D002552:Cerebral Ventricles; D004421:Dystonia / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000134:cerebrospinal fluid; D009127:Muscle Rigidity / Q000134:cerebrospinal fluid; D010300:Parkinson Disease / Q000134:cerebrospinal fluid; D011863:Radioimmunoassay; D013004:Somatostatin / Q000134:cerebrospinal fluid*
D013004:Somatostatin