Dopaminergic and noradrenergic sympathetic nerves of the dog have different DOPA decarboxylase activities.
We have compared the pattern of neural catecholamine fluorescence with that of immunoreactivity for the catecholamine-synthesizing enzymes tyrosine hydroxylase (TH) and DOPA decarboxylase (DDC) in dog atrium, which is innervated by noradrenergic nerves, and in dog kidney, which is thought to be supplied by dopaminergic nerves as well. In both tissues the distribution of nerves containing catecholamine fluorescence was similar to that of nerves exhibiting TH-like immunoreactivity. By contrast, DDC-like immunoreactivity was present in some (but not all) of the nerves associated with the intrarenal blood vessels, but was not detectable in any atrial nerves. High DDC activity provides further confirmation of the existence of sympathetic dopaminergic neurons supplying the kidney.
Harris
T
T
Muller
B
B
Cotton
R G
RG
Borri Voltattorni
C
C
Bell
C
C
D000818:Animals; D001142:Aromatic-L-Amino-Acid Decarboxylases / Q000378:metabolism*; D004285:Dogs; D004296:Dopa Decarboxylase / Q000378:metabolism*; D004298:Dopamine / Q000502:physiology*; D005260:Female; D006325:Heart Atria / Q000294:innervation; D006651:Histocytochemistry; D007120:Immunochemistry; D007668:Kidney / Q000294:innervation; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000201:enzymology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D014446:Tyrosine 3-Monooxygenase; D004296:Dopa Decarboxylase; D001142:Aromatic-L-Amino-Acid Decarboxylases; D004298:Dopamine; D009638:Norepinephrine