title: Clinical pharmacology, pharmacodynamics and interactions with esmolol.
abstract: The clinical pharmacology and pharmacodynamic data from several clinical trials are summarized. The pharmacokinetic profile of esmolol alone and in the presence of digoxin, morphine and warfarin was studied. Conversely the effect of esmolol on these drugs was monitored. No clinically important effects were observed on vital signs, blood chemistry or hematology. The pharmacokinetic interactions associated with administration of these drug combinations were statistically significant in several cases, but they were not considered to be of clinical importance.
authors.forename: D T
authors.initials: DT
authors.lastname: Lowenthal
authors.forename: R S
authors.initials: RS
authors.lastname: Porter
authors.forename: S D
authors.initials: SD
authors.lastname: Saris
authors.forename: C M
authors.initials: CM
authors.lastname: Bies
authors.forename: M B
authors.initials: MB
authors.lastname: Slegowski
authors.forename: A
authors.initials: A
authors.lastname: Staudacher
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000378:metabolism; D002986:Clinical Trials as Topic; D004077:Digoxin / Q000008:administration & dosage / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000378:metabolism; D011412:Propanolamines / Q000008:administration & dosage* / Q000378:metabolism; D013997:Time Factors; D014859:Warfarin / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D014859:Warfarin; D004077:Digoxin; D009020:Morphine; C036604:esmolol