Transfer of pre-embryos donated and fertilized in vivo to recipients given a steroid replacement therapy.
This study describes eleven procedures of non-surgical recovery of preimplantation conceptuses from the uteri of eight fertile donor women and the transfer of the recovered pre-embryos into the uteri of infertile recipients with primary ovarian failure, or with hypothalamic--pituitary failure. Conjugated oestrogens and progesterone were administered to recipients as replacement steroids during the first 20 weeks of pregnancy, in order to produce a secretory endometrium allowing nidation and development of the transferred conceptuses. Five pre-embryo transfers resulted in two viable pregnancies and one early abortion. Non-surgical pre-embryo transfer is a simple and practical method for providing donated ova to women lacking efficient ovarian function.
Formigli
L
L
Toxicology Unit, University of Pavia Medical School, Italy.
Formigli
G
G
Scelsi
R
R
Roccio
C
C
Belotti
G
G
Noè
C
C
D000328:Adult; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use*; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008297:Male; D010060:Ovulation; D011247:Pregnancy / Q000097:blood*; D011374:Progesterone / Q000097:blood / Q000627:therapeutic use*; D014019:Tissue Donors
D004966:Estrogens, Conjugated (USP); D011374:Progesterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone