title: Effects of vecuronium bromide on intracranial pressure and cerebral perfusion pressure. A preliminary report.
abstract: The effects of vecuronium 0.1 mg kg-1 on intracranial pressure, heart rate and arterial pressure were evaluated in 20 anaesthetized patients with intracranial tumours undergoing neurosurgery. Apart from a slight decrease in intracranial pressure (-4.9%; ns) which was most probably the result of a concomitant decrease (-14.9%) in central venous pressure, vecuronium 0.1 mg kg-1 was without effect on either cerebral or systemic haemodynamics.
authors.forename: G
authors.initials: G
authors.lastname: Rosa
authors.forename: M
authors.initials: M
authors.lastname: Sanfilippo
authors.forename: V
authors.initials: V
authors.lastname: Vilardi
authors.forename: P
authors.initials: P
authors.lastname: Orfei
authors.forename: A
authors.initials: A
authors.lastname: Gasparetto
mesh_terms: D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects*; D001932:Brain Neoplasms / Q000503:physiopathology / Q000601:surgery; D002496:Central Venous Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000494:pharmacology; D014673:Vecuronium Bromide
chemical_list: D009466:Neuromuscular Blocking Agents; D014673:Vecuronium Bromide; D010197:Pancuronium