title: Somatostatin's ability to inhibit gastric acid is not prostaglandin-mediated in the dog.
abstract: The role of prostaglandins in the effect of somatostatin to inhibit cholinergically stimulated gastric acid output was examined in gastric fistula dogs. Methacholine stimulation of gastric acid output to a maximum of 810 +/- 423 mu eq of [H+] per 15 min was inhibited by 10 nM somatostatin to the same extent either in the presence and/or the absence of indomethacin. In contrast, histamine-induced acid secretion was stimulated weakly by 10 nM somatostatin. Our data do not support a role for prostaglandins in somatostatin's action to inhibit cholinergically stimulated acid secretion.
authors.forename: J G
authors.initials: JG
authors.lastname: Gerber
authors.forename: M
authors.initials: M
authors.lastname: Hughes
authors.forename: N A
authors.initials: NA
authors.lastname: Payne
mesh_terms: D000818:Animals; D004285:Dogs; D004347:Drug Interactions; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D008688:Methacholine Compounds / Q000494:pharmacology; D011453:Prostaglandins / Q000502:physiology*; D013004:Somatostatin / Q000494:pharmacology*
chemical_list: D008688:Methacholine Compounds; D011453:Prostaglandins; D013004:Somatostatin; D006632:Histamine; D007213:Indomethacin