[The effect of naloxone on basal and maximum gastric secretion in patients with chronic duodenal ulcer].
In 22 men with chronic duodenal ulcer and 15 healthy men effect of a single intravenous injection of 2 mg of naloxone on basis and pentagastrin-stimulated acid output was determined. Naloxone was found to induce a significant decrease in BAO in chronic duodenal ulcer patients; a decrease in BAO in healthy men was insignificant. MAO was not affected by naloxone in both groups. Gastric secretions of potassium, sodium, chloride and mucoprotein were proportional to changes in the volume of the gastric juice. It seems that opioid agonists may play some role in the pathogenesis of duodenal ulcers.
Markiewicz
K
K
Institut für Innere Medizin, Medizinischen Akademie Lódź.
Lukin
M
M
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000293:Adolescent; D000328:Adult; D004381:Duodenal Ulcer / Q000503:physiopathology*; D004723:Endorphins / Q000502:physiology; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism; D006801:Humans; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000502:physiology; D012636:Secretory Rate / Q000187:drug effects
D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone
Der Einfluss von Naloxon auf die basale und maximale Magensekretion bei Personen mit chronischem Duodenalulkus.