title: Dynorphin-A(1-8) and gamma-melanotropin exist within different myenteric plexus neurons of rat duodenum.
abstract: Using the adjacent serial section staining technique and the double staining elution method, it was demonstrated that the opioid peptide dynorphin-A(1-8), originating from the prodynorphin precursor, and gamma 3-melanotropin (gamma 3-MSH), originating from the pro-opiomelanocortin (POMC) precursor, did not co-exist within myenteric plexus perikarya of the rat duodenum. This finding resembles that of the rat brain. Whether gamma 3 -MSH and dynorphin-A(1-8) act synergistically or antagonize each other in some physiological functions or have no interaction at all in the rat duodenum is as yet unknown.
authors.forename: H J
authors.initials: HJ
authors.lastname: Wolter
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D004386:Duodenum / Q000294:innervation*; D004399:Dynorphins / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism*; D009197:Myenteric Plexus / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010446:Peptide Fragments; D004399:Dynorphins; C026770:dynorphin (1-8); D009074:Melanocyte-Stimulating Hormones