title: Meclofenoxate therapy in tardive dyskinesia: a preliminary report.
abstract: Tardive dyskinesia seems to occur as a result of diminished cholinergic and enhanced dopaminergic activity in the striatum. Meclofenoxate has been shown to increase cerebral cholinergic activity. To ameliorate the tardive dyskinesia, meclofenoxate was given orally, 600-1200 mg/day, for 6-12 weeks. The effects of the drug were evaluated by scoring the degree of involuntary movement. Among 11 subjects with tardive dyskinesia or dystonia, 4 improved markedly, 1 moderately, 2 slightly, and there was no improvement in 4. One patient with subacute oral dyskinesia, induced by administration of neuroleptics for 1 month, improved markedly. The possibility that meclofenoxate may be effective in dealing with dyskinesias that are induced by neuroleptics warrants further attention.
authors.forename: K
authors.initials: K
authors.lastname: Izumi
authors.forename: H
authors.initials: H
authors.lastname: Tominaga
authors.forename: T
authors.initials: T
authors.lastname: Koja
authors.forename: M
authors.initials: M
authors.lastname: Nomoto
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Sonoda
authors.forename: K
authors.initials: K
authors.lastname: Imamura
authors.forename: A
authors.initials: A
authors.lastname: Igata
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy*; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy*; D004576:Electromyography; D005260:Female; D006016:Glycolates / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D002504:Meclofenoxate / Q000627:therapeutic use*; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D006016:Glycolates; D002504:Meclofenoxate