Functions of the DnaA protein of Escherichia coli in replication and transcription.
The function of DnaA protein as a replisome organizer in the initiation of DNA replication is reviewed. A model is presented showing the construction of two basic types of DnaA-dependent replication origin. New data demonstrate that the dnaA box-DnaA protein complex is a transcription terminator. Only one orientation of the dnaA box results in termination of transcription. Mutation of the dnaA box within the dnaA reading frame shows that DnaA-mediated transcription termination has a role in the autoregulation of the dnaA gene.
Messer
W
W
Max-Planck-Institut für molekulare Genetik, Berlin, F.R.G.
Seufert
W
W
Schaefer
C
C
Gielow
A
A
Hartmann
H
H
Wende
M
M
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000502:physiology*; D001483:Base Sequence; D004261:DNA Replication; D004926:Escherichia coli; D008969:Molecular Sequence Data; D012097:Repressor Proteins; D014157:Transcription Factors; D014158:Transcription, Genetic
D001426:Bacterial Proteins; D012097:Repressor Proteins; D014157:Transcription Factors