title: Bronchial carcinoid with S-100 positive sustentacular cells.
abstract: A case of double bronchial typical carcinoid of the central type, with a nodal metastasis and paraneoplastic Cushing syndrome is reported. The case is remarkable because both the primary tumors and nodal metastasis were composed of a double cell population: one was arranged in nests, was argyrophilic, immunostained with PHE-5 monoclonal antibody, and contained neurosecretory granules; the other one was neither argyrophilic nor PHE-5-immunoreactive, but was strongly immunoreactive for S-100 protein, had a stellate morphology and was at the periphery of the nests of the other cells. The S-100 immunoreactive cells were regarded as a sort of "sustentacular" or "satellite" cells, which are themselves neoplastic. Bronchial carcinoids with S-100 positive cells, although strictly related with other bronchial carcinoids, may in fact represent a group of tumors with different histogenesis and/or differentiative pattern. More work should be done to elucidate whether there is any relevant clinical difference between bronchial carcinoids with or without S-100 reactive cells.
authors.affiliation: 3rd Chair of Morbid Anatomy and Histopathology, School of Medicine, State University of Milan, Italia.
authors.forename: M
authors.initials: M
authors.lastname: Barbareschi
authors.forename: S
authors.initials: S
authors.lastname: Ferrero
authors.forename: B
authors.initials: B
authors.lastname: Frigo
authors.forename: C
authors.initials: C
authors.lastname: Mariscotti
authors.forename: L
authors.initials: L
authors.lastname: Mosca
mesh_terms: D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D001984:Bronchial Neoplasms / Q000473:pathology*; D002276:Carcinoid Tumor / Q000473:pathology*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D008297:Male; D010257:Paraneoplastic Syndromes / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis*
chemical_list: D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins; D000324:Adrenocorticotropic Hormone