[Effectiveness of adrenergic transmission and mechanisms of its regulation in rats exposed to prenatal effects of ethanol].
Prenatal influence of ethanol doesn't induce the changes of 3H-NA secretion intensity from rat cerebral cortex slices, but induces an increase of coefficient of variation of 3H-NA secretion intensity. The self-facilitation and stabilization of secretion are described during study of 3H-NA secretion intensity in the series of successive depolarization of control animals slices. Prenatal influence of ethanol induces self-facilitation but destabilize 3H-NA secretion. The results show that prenatal influence of ethanol breaks of autoreceptors function which are a cause of 3H-NA secretion destabilization. The break of the higher nervous activity is followed by the break of regulation mechanisms of adrenergic transmission effectiveness which is induced by prenatal influence of ethanol.
Bazian
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D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006613:Higher Nervous Activity / Q000187:drug effects; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000502:physiology
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D000431:Ethanol; D004837:Epinephrine
Effektivnost' adrenergicheskoĭ peredachi i mekhanizmy ee reguliatsii u krys, podvergavshikhsia prenatal'nomu vozdeĭstviiu étanola.