[Analgesic activity of pymadine].
The analgesic effect of 4-aminopyridine (pymadine) was studied in experiments on rats and mice at thermal and chemical pain stimulation. Pymadine (1, 3 and 5 mg/kg) exerted the analgesic effect when administered alone and concomitantly with analgin and morphine at chemical pain stimulation. During thermal pain stimulation pymadine had the analgesic effect only at dosage of 5 mg/kg and potentiated the action of morphine given in doses of 3 and 5 mg/kg. The same doses of pymadine failed to influence changes in pain reaction induced by analgin at thermic pain stimulation.
Mitsov
V
V
Bantutova
I
I
D015761:4-Aminopyridine; D000631:Aminopyridines / Q000627:therapeutic use*; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D004177:Dipyrone / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D008297:Male; D051379:Mice; D009020:Morphine / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
D000631:Aminopyridines; D000700:Analgesics; D004177:Dipyrone; D009020:Morphine; D015761:4-Aminopyridine
Issledovanie anal'geticheskoĭ aktivnosti pimadina.