title: Double-blind trial of CL115,347, a transdermally absorbed prostaglandin E2 analogue, in treatment of Raynaud's phenomenon.
abstract: CL115,347 (Cyanamid International) is a stable transdermally absorbed prostaglandin E2 analogue said to have an antiplatelet vasodilatory effect. In a trial of this drug in Raynaud's phenomenon 15 patients were given 1 mg CL115,347/day transdermally for 6 weeks and 14 were given a placebo. The treated group had fewer and shorter spasm attacks and better healing of ulcers as assessed on a visual analogue scale. Blood supply as measured by cold challenge plethysmography ('Medimatic SP2') was also improved by CL115,347, as were hand temperatures. The treated group also had a significant rise in platelet count, but initial decreases in platelet aggregation were not maintained up to the end of the study.
authors.forename: J J
authors.initials: JJ
authors.lastname: Belch
authors.forename: R
authors.initials: R
authors.lastname: Madhok
authors.forename: B
authors.initials: B
authors.lastname: Shaw
authors.forename: P
authors.initials: P
authors.lastname: Leiberman
authors.forename: R D
authors.initials: RD
authors.lastname: Sturrock
authors.forename: C D
authors.initials: CD
authors.lastname: Forbes
mesh_terms: D000287:Administration, Topical; D001792:Blood Platelets / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005385:Fingers / Q000098:blood supply; D006801:Humans; D008297:Male; D010991:Plethysmography; D011928:Raynaud Disease / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D012039:Regional Blood Flow / Q000187:drug effects; D012881:Skin Temperature