title: Glucagon secretion in the hibernating edible dormouse (Glis glis).
abstract: Plasma glucose and glucagon concentrations were measured in edible dormice during the bout of hibernation, arousal and active periods. During lethargy, plasma glucose and glucagon were low, compared to active values and did not fluctuate throughout the phase. During rewarming, plasma glucose regularly increased from 17 degrees to 37 degrees C while plasma glucagon rose after the 17 degrees C stage and reached the higher values at 26 degrees C, then slightly decreased at 37 degrees C. During arousal, plasma levels of free amino acids progressively increased. The effect of temperature and secretagogue (glucose and arginine) on glucagon secretion was studied using perfused pancreas from hibernating edible dormouse. In vitro rewarming of pancreas induced an increase in glucagon secretion. Glucagon secretion was regulated by glucose (inhibitory effect) and by arginine (stimulating effect) up to 25 degrees C. The effect of temperature and glucagon on oxygen uptake of hibernating edible dormouse brown fat was studied using an in vitro technique. Rewarming strongly increased oxygen consumption from 10 to 37 degrees C. Glucagon enhanced oxygen consumption up to 20 degrees C.
authors.forename: R
authors.initials: R
authors.lastname: Hoo-Paris
authors.forename: C
authors.initials: C
authors.lastname: Castex
authors.forename: M
authors.initials: M
authors.lastname: Hamsany
authors.forename: A
authors.initials: A
authors.lastname: Thari
authors.forename: B
authors.initials: B
authors.lastname: Sutter
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism; D000818:Animals; D001143:Arousal; D001786:Blood Glucose / Q000032:analysis; D005934:Glucagon / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D006605:Hibernation; D007700:Kinetics; D009043:Motor Activity; D010101:Oxygen Consumption / Q000187:drug effects; D010179:Pancreas / Q000378:metabolism; D012377:Rodentia / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D005934:Glucagon