[The role of GABA-benzodiazepine receptor complex in affecting the anxiolytic effect of 3-hydroxypyridines--new non-benzodiazepine tranquilizers].
The experiments on rats, using conflict situation method, have established that anxiolytic effect of 3-hydroxypyridine derivative is removed by bicucullin and picrotoxin, but not by Ro 5-3663, specific antagonist of benzodiazepine receptors Ro 15-1788 and inversive antagonist ethyl beta-carboline-3-carboxylate. The data obtained suggest that GABA-chloriontophor complex is involved into the realization of 3-hydroxypyridine anxiolytic effect.
Voronina
T A
TA
Smirnov
L D
LD
Tilekeeva
U M
UM
Diumaev
K M
KM
D000818:Animals; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D011725:Pyridines; D011963:Receptors, GABA-A; C023500:3-hydroxypyridine
Rol' GAMK-benzodiazepin-retseptornogo kompleksa v realizatsii anksioliticheskogo deĭstviia 3-oksipiridinov--novykh trankvilizatorov nebenzodiazepinovoĭ struktury.