Impairment of the respiratory chain in the b-c1 region as early functional event during Fe2+/ascorbate induced peroxidation in rat liver mitochondria.
An attack at the level of the respiratory chain was established as the reason for the early inhibition of oxygen uptake during Fe2+/ascorbate induced peroxidation by following the activities of complexes I-IV separately. The close correlation between the decline of mitochondrial respiration and the activity of complex III strongly suggests that an impairment of the respiratory chain in the b-c1 region represents one of the first functional events in the causal sequence of peroxidative reactions preceding the phase of massive malondialdehyde production.
Trümper
L
L
Institut für Biochemie, Medizinische Akademie Magdeburg, GDR.
Hoffmann
B
B
Wiswedel
I
I
Augustin
W
W
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D014450:Electron Transport Complex III / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism; D005296:Ferrous Compounds / Q000494:pharmacology*; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats
D005296:Ferrous Compounds; C051140:iron(II)-ascorbic acid complex; D008315:Malondialdehyde; D003576:Electron Transport Complex IV; D014450:Electron Transport Complex III; D001205:Ascorbic Acid