Effects of metoclopramide on detrusor function.
Metoclopramide (Reglan) has been widely used as a motility agent because of its contractile effects on gastrointestinal smooth muscle. This agent also may demonstrate significant effects in the urinary system; however, controlled studies of possible effects on bladder function have not been previously reported. Metoclopramide effects on the detrusor smooth muscle were studied using a canine model system. Metoclopramide was compared with bethanechol chloride and a control substance in a random double blind study. Preliminary data from this animal model suggests that metoclopramide significantly increased detrusor contractility as manifested by a decrease in bladder capacity, an increase in detrusor peak voiding pressure and a decrease in post-void residual volume. These effects were similar to those manifested by parenteral bethanechol chloride.
Mitchell
W C
WC
Venable
D D
DD
D000818:Animals; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000494:pharmacology; D004285:Dogs; D004311:Double-Blind Method; D005260:Female; D008787:Metoclopramide / Q000494:pharmacology* / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects*; D011312:Pressure; D001743:Urinary Bladder / Q000187:drug effects*; D014554:Urination; D014563:Urodynamics
D001626:Bethanechol Compounds; D018723:Bethanechol; D008787:Metoclopramide