[The role of cyclic 3',5'-adenosine monophosphate in the extinction of the reaction of identified neurons in the edible snail to acetylcholine].
The recording of transmembrane currents and intracellular potentials has been used to show on Helix lucorum identified neurons RPa4, RPa3 and LPa3, that pharmacologic effects on adenylate cyclase system do not influence the extinction of neuronal response to repeated local iontophoretic applications of acetylcholine to the soma. Neither cAMP-raising adenylate cyclase activator forskolin (2-6 x 10(-5) mol/l), nor cAMP-lowering phosphodiesterase activator imidazole (5 x 10(-3) mol/l) alter the dynamics of extinction of response to acetylcholine. A conclusion has been made that shortterm plasticity of cholinoreceptors in the investigated neurons is independent of intracellular cAMP level.
Pivovarov
A S
AS
Drozdova
E I
EI
Kotliar
B I
BI
D000109:Acetylcholine / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology*; D004558:Electric Stimulation; D005108:Extinction, Psychological / Q000187:drug effects* / Q000502:physiology; D006372:Helix, Snails / Q000187:drug effects / Q000502:physiology*; D007093:Imidazoles / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009473:Neuronal Plasticity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology
D007093:Imidazoles; D011950:Receptors, Cholinergic; D005576:Colforsin; C029899:imidazole; D000242:Cyclic AMP; D000109:Acetylcholine
Izuchenie roli tsiklicheskogo 3',5'-adenozinmonofosfata v ugashenii reaktsiĭ identifitsirovannykh neĭronov vinogradnoĭ ulitki na atsetilkholin.