title: Histological changes in mouse liver and spleen caused by different Coxiella burnetii antigenic preparations.
abstract: The effect was examined on mouse liver and spleen (inbred line A) of intraperitoneal (i.p.) inoculation of phase I Coxiella burnetii (C.b.) cells either untreated or treated with chloroform-methanol (CM) mixture in comparison to the trichloracetic acid extract (TCAE) from phase I C.b.) cells. The phase I C.b. cells were highly toxic as manifested by marked hepatosplenomegaly accompanied with hyperplastic, degenerative and necrotic changes in the liver. By contrast, phase I CM--treated C.b. cells and TCAE were nontoxic as evidenced by the absence of any distinct pathological changes in mouse viscera.
authors.forename: I N
authors.initials: IN
authors.lastname: Kokorin
authors.forename: V I
authors.initials: VI
authors.lastname: Pushkareva
authors.forename: J
authors.initials: J
authors.lastname: Kazár
authors.forename: S
authors.initials: S
authors.lastname: Schramek
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000302:isolation & purification / Q000633:toxicity*; D003381:Coxiella / Q000276:immunology*; D008099:Liver / Q000187:drug effects / Q000382:microbiology / Q000473:pathology*; D051379:Mice; D013154:Spleen / Q000187:drug effects / Q000382:microbiology / Q000473:pathology*
chemical_list: D000942:Antigens, Bacterial