Effects of dehydration on pro-dynorphin derived peptides in the neuro-intermediate lobe of the rat pituitary.
Dehydration significantly reduced the concentration of immunoreactive dynorphin A(1-17), dynorphin A(1-8), alpha-neo-endorphin, beta-neo-endorphin, and leu-enkephalin in the rat pituitary posterior-intermediate lobe. A statistically significant increase in immunoreactive dynorphin A(1-8), alpha-neo-endorphin and leu-enkephalin was observed in the hypothalamus. Comparison of the molar ratios of dynorphin A(1-17): dynorphin A(1-8) and alpha-neo-endorphin: beta-neo-endorphin showed an altered profile of stored pro-dynorphin cleavage products in the posterior-intermediate lobe of the pituitary of dehydrated rats.
Lorenz
R G
RG
Evans
C J
CJ
Barchas
J D
JD
D000818:Animals; D003681:Dehydration / Q000378:metabolism*; D004399:Dynorphins / Q000378:metabolism; D004723:Endorphins / Q000378:metabolism; D004743:Enkephalin, Leucine / Q000378:metabolism; D004745:Enkephalins / Q000378:metabolism*; D005508:Food Deprivation; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D010446:Peptide Fragments / Q000378:metabolism; D010904:Pituitary Gland, Posterior / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin / Q000031:analogs & derivatives*
D004723:Endorphins; D004745:Enkephalins; D010446:Peptide Fragments; D011498:Protein Precursors; D004743:Enkephalin, Leucine; D001615:beta-Endorphin; C025681:alpha-neoendorphin; D004399:Dynorphins; C026770:dynorphin (1-8); C030719:beta-neo-endorphin; C033660:preproenkephalin