title: Disorders of cobalamin metabolism.
abstract: Recent developments in our knowledge of the biochemistry and metabolism of cobalamin have given us some insight into clinical disorders. N2O, which easily induces cobalamin deficiency, both in vivo and in vitro, has greatly contributed to the investigation of the cobalamin deficient state, especially in relation to folate and amino acid metabolism. Demonstration of the cobalamin analog in human serum and a new enzyme which requires cobalamin as a coenzyme has led to recent increased interest in this field. The disorders of cobalamin metabolism will be summarized briefly as well as those areas currently of particular interest.
authors.forename: Y
authors.initials: Y
authors.lastname: Kano
authors.forename: S
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Miura
authors.forename: F
authors.initials: F
authors.lastname: Takaku
mesh_terms: D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000378:metabolism; D000591:Amino Acid Isomerases / Q000378:metabolism; D000752:Anemia, Pernicious / Q000150:complications / Q000378:metabolism; D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004169:Diphyllobothriasis / Q000150:complications; D005492:Folic Acid / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D019751:Intramolecular Transferases; D008286:Malabsorption Syndromes / Q000150:complications; D008765:Methylmalonyl-CoA Mutase / Q000378:metabolism; D008780:Methyltransferases / Q000378:metabolism; D009422:Nervous System Diseases / Q000209:etiology; D009609:Nitrous Oxide / Q000633:toxicity; D010182:Pancreatic Diseases / Q000150:complications; D013938:Thymidine Monophosphate / Q000096:biosynthesis; D014805:Vitamin B 12 / Q000378:metabolism*; D015043:Zollinger-Ellison Syndrome / Q000378:metabolism
chemical_list: D013938:Thymidine Monophosphate; D004247:DNA; D005492:Folic Acid; D008780:Methyltransferases; D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; D000591:Amino Acid Isomerases; D019751:Intramolecular Transferases; C021507:leucine 2,3-aminomutase; D008765:Methylmalonyl-CoA Mutase; D009609:Nitrous Oxide; D014805:Vitamin B 12