title: A metastatic endocrine-neurogenic tumor of the ampulla of Vater with multiple endocrine immunoreaction--malignant paraganglioma?
abstract: The present case report demonstrates the history of a 50-year-old man with a mixed endocrine-neurogenous tumor of the ampulla of Vater. The tumor was localized endoscopically after an attack of melena. There were no signs of endocrinopathy. A local resection with suturing of the pancreatic duct was performed. Morphologically, there were two different tissue types (neurogenous and carcinoid-like) with numerous cells and nerve fibers reacting immunohistochemically with somatostatin and neurotensin antisera: some immunoreactivity to PP-antibodies was observed. Still, after 20 months, the patient seems to have been cured by local resection.
authors.forename: M
authors.initials: M
authors.lastname: Büchler
authors.forename: P
authors.initials: P
authors.lastname: Malfertheiner
authors.forename: K
authors.initials: K
authors.lastname: Baczako
authors.forename: W
authors.initials: W
authors.lastname: Krautzberger
authors.forename: H G
authors.initials: HG
authors.lastname: Beger
mesh_terms: D014670:Ampulla of Vater / Q000473:pathology; D001079:Apudoma / Q000556:secondary; D002276:Carcinoid Tumor / Q000556:secondary; D003138:Common Bile Duct Neoplasms / Q000473:pathology / Q000556:secondary*; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009496:Neurotensin / Q000378:metabolism*; D010191:Pancreatic Polypeptide / Q000378:metabolism*; D010235:Paraganglioma / Q000473:pathology / Q000556:secondary*; D013004:Somatostatin / Q000378:metabolism*
chemical_list: D009496:Neurotensin; D013004:Somatostatin; D010191:Pancreatic Polypeptide