Phenelzine poisoning.
A 46-year-old female with severe phenelzine poisoning was managed successfully by alpha blockade and fluid loading, with the aid of invasive haemodynamic monitoring. The pathophysiology was documented, showing elevated plasma and urinary catecholamines, cardiovascular abnormalities and a contracted blood volume. Most of these changes were reversed following treatment.
Breheny
F X
FX
Dobb
G J
GJ
Clarke
G M
GM
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D002395:Catecholamines / Q000378:metabolism; D003422:Critical Care; D005260:Female; D005440:Fluid Therapy; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010624:Phenelzine / Q000506:poisoning*
D000317:Adrenergic alpha-Antagonists; D002395:Catecholamines; D010624:Phenelzine