Ethyl eicosapentaenoate restored the immunosuppression in mice fed fat-free diet.
The effects of eicosapentaenoic acid (EPA) on the humoral immune response in fat free diet-fed (FF) mice were studied. The lowered anti-SRBC PFC activity of ICR male FF mice was restored in a dose-dependent manner when EPA was administered orally at doses of 60-360 mg/kg/day for 20 days. In in vitro experiments, EPA similarly enhanced anti-SRBC PFC activity but did not affect the response against lipopolysaccharide. Furthermore, EPA did not cause any substantial effect on T suppressor cell activity induced by Concanavalin A in vitro. On the other hand, T helper cell activity induced by keyhole limpet hemocyanin was augmented. From these results, it is suggestive that EPA caused immunopotentiation to FF mice at least partially by an enhancement of T helper cell activities.
Wee
L H
LH
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Ueno
K
K
Takeda
H
H
Soma
K
K
Kitagawa
H
H
Satoh
T
T
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology; D004041:Dietary Fats / Q000008:administration & dosage*; D015118:Eicosapentaenoic Acid / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology; D007165:Immunosuppression Therapy; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D004041:Dietary Fats; D008070:Lipopolysaccharides; D003208:Concanavalin A; D015118:Eicosapentaenoic Acid