title: Peroxidation of phospholipids promoted by myeloperoxidase.
abstract: Myeloperoxidase was found to promote peroxidation of phospholipids under acidic conditions in the presence of hydrogen peroxide and iodide ions. The peroxidation was markedly enhanced by pyrophosphate-chelated ferric iron and was inhibited by desferrioxamine and superoxide dismutase. This observation adds lipid peroxidation to the oxidative damage caused by myeloperoxidase, which is a phagocytic cell enzyme involved in phagocyte-mediated cell destruction.
authors.affiliation: Department of Experimental Medicine, Pharmacia AB, Uppsala, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Carlin
authors.forename: R
authors.initials: R
authors.lastname: Djursäter
mesh_terms: D006801:Humans; D006861:Hydrogen Peroxide; D006863:Hydrogen-Ion Concentration; D007454:Iodides; D007502:Iron Chelating Agents; D015227:Lipid Peroxidation; D009195:Peroxidase / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*
chemical_list: D007454:Iodides; D007502:Iron Chelating Agents; D010743:Phospholipids; D006861:Hydrogen Peroxide; D009195:Peroxidase