Retrieval of precursors for white-type adipose conversion in brown adipose tissue.
A cellular compartment from brown adipose tissue (BAT) of newborn rats was isolated by Percoll-density-gradient centrifugation and was shown to proliferate and to undergo adipose conversion in vitro in primary culture. The features of the effector requirement for adipose conversion as well as the differentiated morphological and biochemical phenotype are almost identical with that of a compartment designated HCF, from white adipose tissue (WAT). A possible role for these precursors from BAT and WAT in the involution of BAT into WAT, on the one hand, and in the development of brown adipose cells among typical WAT deposits, on the other, is discussed.
Poissonnet
C M
CM
Centre de Biologie du Développement, Hôpital Port-Royal, Paris, France.
Ouagued
M
M
Aron
Y
Y
Pello
J Y
JY
Swierczewski
E
E
Krishnamoorthy
R
R
D002001:Adipose Tissue, Brown / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002451:Cell Compartmentation; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003576:Electron Transport Complex IV / Q000378:metabolism; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D006728:Hormones / Q000494:pharmacology; D008071:Lipoprotein Lipase / Q000378:metabolism; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D051381:Rats
D006728:Hormones; D005993:Glycerolphosphate Dehydrogenase; D003576:Electron Transport Complex IV; D008071:Lipoprotein Lipase