Complementation of class II A alleles in the immune response to (GluLysTyr) polymers.
The proliferative T cell responses to poly(GluLysTyr) (GLT) and poly(GLULysPhe) (GLPhe) are restricted by the E alpha E beta class II MHC molecule (E) in most responded strains. Some nonresponder strains that carry responder E beta, but cannot express cell surface E molecules, can complement with other nonresponder strains that provide the missing E alpha chain needed for the expression of E molecules and for responsiveness to GLT and GLPhe. Here another type of complementation is described between two E-nonexpressor haplotypes, H-2f and H-2s, which result in E-nonexpressor F1 hybrids, which are responders to GLT. The restriction element involved in this response is an Af/As hybrid molecule. The data support the hypothesis that conformational determinants resulting from the free association of alpha and beta chains in heterozygotes can increase the immune potential of the individual.
Lai
C H
CH
Department of Biochemistry, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pa.
Babu
U M
UM
Matsunaga
K
K
Nagy
Z A
ZA
Klein
J
J
Turchin
H A
HA
Maurer
P H
PH
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D003429:Cross Reactions; D005816:Genetic Complementation Test; D006183:H-2 Antigens / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology; D010455:Peptides / Q000276:immunology*; D011108:Polymers; D011487:Protein Conformation; D055503:Protein Multimerization; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II; D010455:Peptides; D011108:Polymers; C022272:glutamic acid-lysine-tyrosine terpolymer; C027143:poly(Glu(56)-Lys(35)-Phe(9))n