title: Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists.
abstract: The effectiveness of several excitatory amino acid antagonists to delay or block seizures induced by oxygen at high pressure was examined in mice. Of the antagonists tested, namely, L-proline, DL-alpha-aminoadipate, DL-2-amino-5-phosphonovalerate, and L-glutamic acid diethyl ester, DL-2-amino-5-phosphonovalerate was the most effective in delaying or preventing seizures. L-Glutamic acid diethylester was also effective but at significantly higher doses, which were also associated with marked sedation.
authors.forename: C A
authors.initials: CA
authors.lastname: Colton
authors.forename: J S
authors.initials: JS
authors.lastname: Colton
mesh_terms: D015763:2-Amino-5-phosphonovalerate; D015074:2-Aminoadipic Acid / Q000494:pharmacology; D000596:Amino Acids / Q000037:antagonists & inhibitors*; D000818:Animals; D000927:Anticonvulsants; D005971:Glutamates / Q000494:pharmacology; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D051379:Mice; D011392:Proline / Q000494:pharmacology; D012640:Seizures / Q000209:etiology / Q000517:prevention & control*; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D000927:Anticonvulsants; D005971:Glutamates; C011829:glutamic acid diethyl ester; D015074:2-Aminoadipic Acid; D015763:2-Amino-5-phosphonovalerate; D011392:Proline; D014633:Valine