Polyarteritis nodosa associated with biclonal gammopathy of two-cell line origin and amyloidosis.
A patient suffering from polyarteritis nodosa associated with a biclonal gammopathy with amyloidosis was studied to investigate the role of the paraproteins in the production of vascular lesions. The use of specific antiidiotypic antibodies allowed comparison of the variable regions of the two M-components and investigation of their cellular origin as well as their presence in vasculitis lesions. No idiotypic determinant shared by the 2 molecules was found and these paraproteins were found to be secreted by 2 different cell lines. In contrast with the presence of polyclonal immunoglobulins and complement, the paraproteins were absent in damaged arterial walls. These results indicate that the 2 diseases were independent.
Bouvet
J P
JP
Delrieu
F
F
D000686:Amyloidosis / Q000150:complications*; D001158:Arteries / Q000378:metabolism; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000378:metabolism; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes / Q000032:analysis; D007136:Immunoglobulins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D010488:Polyarteritis Nodosa / Q000150:complications*; D012867:Skin / Q000378:metabolism
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes; D007136:Immunoglobulins