Selenium deficiency and possible increased risk of carcinoma in adults with cystic fibrosis.
20 young adults with cystic fibrosis (CF), including 2 with cancer, were found to have low serum selenium concentrations. Serum vitamin E concentrations were also low. It is suggested that low levels of circulating selenium are associated with increased risk of carcinoma, particularly in the presence of reduced vitamin E levels. Older patients with CF may be at increased risk for the development of carcinoma.
Stead
R J
RJ
Redington
A N
AN
Hinks
L J
LJ
Clayton
B E
BE
Hodson
M E
ME
Batten
J C
JC
D000328:Adult; D003550:Cystic Fibrosis / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000209:etiology*; D008297:Male; D010190:Pancreatic Neoplasms / Q000209:etiology*; D012306:Risk; D012643:Selenium / Q000097:blood / Q000172:deficiency*; D014810:Vitamin E / Q000097:blood
D014810:Vitamin E; D012643:Selenium