title: A one-shot lactate-editing sequence for localized whole-body spectroscopy.
abstract: A pulse sequence is presented for performing localized lactate-edited proton spectroscopy in the whole-body environment. The sequence is optimized for relatively low field strength (1.5-T) clinical measurements. Characteristics of this method of lactate editing, which makes it more suitable for clinical applications than previous methods, include the following: The "one shot" nature of the method makes it relatively insensitive to patient motion; water suppression is high as all 90 degrees pulses are binomial pulses; and very narrow band rf pulses, such as used in high-field lactate-editing sequences, but which are necessarily very long at low fields, are not required. Further, this lactate editing scheme can be very easily combined with localized spectroscopic measurements.
authors.affiliation: Institute of Biomedical Engineering and Medical Informatics, Swiss Federal Institute of Technology, Zurich.
authors.forename: G C
authors.initials: GC
authors.lastname: McKinnon
authors.forename: P
authors.initials: P
authors.lastname: Boesiger
mesh_terms: D006801:Humans; D007773:Lactates; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011522:Protons
chemical_list: D007773:Lactates; D011522:Protons