title: A silencer element from the alpha-globin gene inhibits expression of beta-like genes.
abstract: We have studied the cis and trans interactions of the alpha- and beta-globin genes in a transient expression system. We found that the alpha-globin gene inhibited beta-globin expression in cis but not in trans. The silencer element responsible for this inhibition was localized to a 259-base-pair fragment at the 5' end of the alpha-globin gene.
authors.affiliation: Department of Medicine, University of Michigan School of Medicine, Ann Arbor.
authors.forename: G F
authors.initials: GF
authors.lastname: Atweh
authors.forename: J M
authors.initials: JM
authors.lastname: Liu
authors.forename: H E
authors.initials: HE
authors.lastname: Brickner
authors.forename: X X
authors.initials: XX
authors.lastname: Zhu
mesh_terms: D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D005809:Genes, Regulator; D008040:Genetic Linkage; D005914:Globins / Q000235:genetics*; D006367:HeLa Cells; D006801:Humans; D005810:Multigene Family; D013539:Simian virus 40 / Q000235:genetics
chemical_list: D005914:Globins