In vitro activity of six quinolone derivatives against Neisseria gonorrhoeae.
The in vitro activities of six quinolone derivatives, rosoxacin, pefloxacin, ofloxacin, ciprofloxacin, A-56619 and A-56620, were compared with those of penicillin, cefotaxime, spectinomycin, chloramphenicol, tetracycline and erythromycin against 50 nonpenicillinase-producing and 15 penicillinase-producing Neisseria gonorrhoeae strains. Ciprofloxacin was the most active compound in vitro (MIC50, 0.004 mg/l) followed by ofloxacin and A-56620 (MIC50, 0.008 mg/l), A-56619 and cefotaxime (MIC50, 0.016 mg/l). The six quinolones are highly active against all the strains tested but 2, with decreased sensitivity.
Lefèvre
J C
JC
Groupe Etude et Prévention des Maladies Transmissibles, Faculté de Médecine Purpan, Toulouse, France.
Tempesta
M C
MC
Gaubert
E
E
Lareng
M B
MB
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D010405:Penicillinase / Q000096:biosynthesis; D015363:Quinolones / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D015363:Quinolones; D010405:Penicillinase