Converting enzyme inhibitors (captopril, enalapril, perindopril) prevent early-post infarction ventricular fibrillation in the anaesthetized rat.
The angiotensin-converting enzyme inhibitors, captopril, enalapril and perindopril, exert antiarrhythmic effects on early post-infarction arrhythmias in anaesthetized rats. These studies support the hypothesis that converting enzyme inhibitors could have a "cardioprotective" effect, but the doses used are probably "high" in relation to those therapeutically applicable to man.
Ribuot
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Laboratoire de Pharmacodynamie et de Physiologie Pharmaceutique, Faculté de Pharmacie-Université de Dijon, France.
Rochette
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D000758:Anesthesia; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D002216:Captopril / Q000627:therapeutic use; D004656:Enalapril / Q000627:therapeutic use; D007211:Indoles / Q000627:therapeutic use; D008297:Male; D009203:Myocardial Infarction / Q000150:complications*; D020913:Perindopril; D051381:Rats; D011919:Rats, Inbred Strains; D014693:Ventricular Fibrillation / Q000209:etiology / Q000517:prevention & control*
D000806:Angiotensin-Converting Enzyme Inhibitors; D007211:Indoles; D004656:Enalapril; D002216:Captopril; D020913:Perindopril