Somatostatin binding sites in cytosolic fractions of parietal and non-parietal cells from rabbit fundic mucosa.
Specific binding sites for somatostatin have been found in the cytosolic fractions of both parietal and non-parietal cells from rabbit gastric fundic mucosa. The stoichiometric data suggested the presence of two classes of binding sites in both types of cells. The number of low-affinity binding sites was significantly higher in parietal cells than in non-parietal cells. The reverse was true for the high-affinity binding sites. However, the affinity of each class of binding sites was similar in the cytosolic fractions of both parietal and non-parietal cells. It thus appears that low-affinity somatostatin binding sites are mainly located in the parietal cells whereas the high-affinity sites occur principally in the non-parietal cells.
Arilla
E
E
López-Ruiz
M P
MP
Gonzalez-Guijarro
L
L
Prieto
J C
JC
D000818:Animals; D001665:Binding Sites; D003600:Cytosol / Q000378:metabolism; D005748:Gastric Fundus / Q000166:cytology / Q000378:metabolism; D005753:Gastric Mucosa / Q000166:cytology / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011817:Rabbits; D013004:Somatostatin / Q000378:metabolism*
D013004:Somatostatin