Mitochondrial monoamine oxidase activity during preneural developmental stages of Bufo bufo.
Monoamine oxidase specific activities against PEA and 5-HT have been measured in mitochondria isolated from early embryos of Bufo bufo. During the early development up to the neural fold stage, MAO activity undergoes a continuous decrease that is more evident when PEA is used as the substrate. The inhibition patterns of deprenyl and clorgyline demonstrate that, at the neural fold stage, both type A and B MAO are present. Both in eggs and embryos MAO type A activity appears slightly more sensitive to the inhibitory effect of various concentrations (0.1-2 M) of the denaturing agent urea.
Senatori
O
O
Nicotra
A
A
D000818:Animals; D002023:Bufo bufo / Q000196:embryology*; D003010:Clorgyline / Q000494:pharmacology; D004625:Embryo, Nonmammalian / Q000201:enzymology / Q000502:physiology*; D005260:Female; D007700:Kinetics; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D008995:Monoamine Oxidase / Q000378:metabolism*; D009420:Nervous System / Q000196:embryology*; D012642:Selegiline / Q000494:pharmacology; D014508:Urea / Q000494:pharmacology
D012642:Selegiline; D014508:Urea; D008995:Monoamine Oxidase; D003010:Clorgyline