Intracellular sodium and calcium during antihypertensive treatment.
In 49 untreated essential hypertensives the effects of the loop diuretic, piretanide, in a dose of 12 mg daily (n = 14) and of 6 mg daily (n = 18) as well as of beta blockers (pindolol, metipranolol, atenolol, n = 17) on blood pressure, intracellular Ca++ and Na+ activity in red blood cells were examined. Intracellular ion activities were measured by ion-selective electrodes. The higher dose of piretanide caused a decrease of intracellular Ca++ activity and an increase of intracellular Na+ activity. Under the lower dose of piretanide there was a comparable decrease of intracellular Ca++ activity but no significant change of intracellular Na+ activity. Beta blockers decreased intracellular Ca++ activity but left intracellular Na+ activity unchanged. It is concluded that intracellular free Ca++ plays an important role in the regulation of vascular tone in essential hypertension. There seems to be no direct relation between intracellular free Na+ and blood pressure under antihypertensive therapy.
Zidek
W
W
Karoff
C
C
Baumgart
P
P
Losse
H
H
Fehske
K J
KJ
Häcker
W
W
Vetter
H
H
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001262:Atenolol / Q000627:therapeutic use; D001826:Body Fluids / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D007424:Intracellular Fluid / Q000378:metabolism*; D014290:Metipranolol / Q000627:therapeutic use; D008875:Middle Aged; D010869:Pindolol / Q000627:therapeutic use; D012964:Sodium / Q000097:blood*; D013449:Sulfonamides / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D013449:Sulfonamides; D001262:Atenolol; D012964:Sodium; D010869:Pindolol; C015451:piretanide; D002118:Calcium; D014290:Metipranolol