[T-lymphocyte precursor count in the thymus and the development of lymphomas in AKR/J-strain mice].
The content of T-cell precursors is increased in the thymus of AKR/J mice. Thymus also contains cells carrying markers of pre-T (SC-1-antigen) and T-(Thy-1-antigen) cells simultaneously. The level of SC-1+-cells grows just before the lymphoma appearance in the AKR/J thymus. Lymphoma cells express both SC-1 and Thy-1-antigens, i. e. they are a transitional form between pre-T- and T-cells. It is suggested that accumulation of SC-1+-Thy-1+ cells in the mouse thymus is an essential condition for the development of virus-induced lymphomas.
Kochergina
N I
NI
Iarilin
A A
AA
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D003601:Cytotoxicity Tests, Immunologic; D006168:Guinea Pigs; D007114:Immunization; D007958:Leukocyte Count; D008223:Lymphoma / Q000209:etiology* / Q000276:immunology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR / Q000276:immunology*; D008808:Mice, Inbred CBA; D009929:Organ Size; D011230:Precancerous Conditions / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D013234:Stem Cells / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D018800:Thy-1 Antigens; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D018800:Thy-1 Antigens
Soderzhanie predshestvennikov T-limfotsitov v timuse i razvitie limfom u mysheĭ linii AKR/J.