[Changes in the sensitivity of brain dopamine and serotonin receptors during the prolonged administration of carbidine].
Male Wistar rats were treated chronically with either carbidine (10 mg/kg/day) or haloperidol (1 mg/kg/day) for 23 consecutive days. On days 4-5 after the treatment discontinuation the animals were challenged with apomorphine HCl (0.5 mg/kg) or 5-OTP (150 mg/kg i. p) in combination with pargiline (40 mg/kg i. p) and stereotype responses were scored. In carbidine-treated rats the intensity of stereotype sniffings was increased after apomorphine treatment. In contrast, animals treated with haloperidol exhibited more intensive gnawing after apomorphine in comparison to vehicle-treated rats. 5-OTP-induced head twitches were increased only in carbidine-treated rats. Prolonged carbidine treatment in contrast to haloperidol induced a decrease in 5H-spiperone and 3H-LSD binding in the frontal cortex, with the density of D-2 receptors in the striatum practically unchanged. It is concluded that neuroleptic carbidine in contrast to classical neuroleptics has a more selective effect in serotonin (S-2) receptors and antidepressive properties of this compound may be due to the down-regulation of S-2 receptors in the brain.
Zharkovskiĭ
A M
AM
Chereshka
K S
KS
Zharkovskaia
T A
TA
Allikmets
L Kh
LKh
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D002243:Carbolines / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D014150:Antipsychotic Agents; D002243:Carbolines; D008996:Monoamine Oxidase Inhibitors; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D010293:Pargyline; D006916:5-Hydroxytryptophan; D006220:Haloperidol; D001058:Apomorphine; C100106:dicarbine
Izmenenie chuvstvitel'nosti dofaminovykh i serotoninovykh retseptorov mozga pri dlitel'nom vvedenii karbidina.