The anxiolytic but not the sedative properties of tracazolate are reversed by the benzodiazepine receptor antagonist, Ro 15-1788.
The effects of the novel putative anxiolytic, tracazolate, were investigated in the social interaction of anxiety and the holeboard. Tracazolate (5 mg/kg) had an anxiolytic action that was no longer observed at higher doses (10-25 mg/kg); in the holeboard tracazolate produced a dose-related (5-25 mg/kg) depression of exploratory head-dipping, locomotor activity and rearing. The effects of tracazolate in the social interaction test, but not in the holeboard, could be reversed by the benzodiazepine receptor antagonist, Ro 15-1788 (10 mg/kg).
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D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001570:Benzodiazepinones / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology*; D005442:Flumazenil; D006993:Hypnotics and Sedatives; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D003292:Convulsants; D006993:Hypnotics and Sedatives; D011720:Pyrazoles; D011963:Receptors, GABA-A; D005442:Flumazenil; C034317:tracazolate