The regulatory effect of histamine on the in vitro synthesis of IgE.
The effect of histamine and its H1 and H2 antagonists, chlorpheniramine and cimetidine, on the in vitro, PWM-induced, synthesis of IgG and IgE was studied. Histamine had no effect, and cimetidine had a slight inhibitory action. In contrast, chlorpheniramine induced marked suppression of both IgE and IgG synthesis. This effect could not be attributed to drug-induced cytotoxicity. These results suggest that the modulatory effect of histamine on antibody production involves predominantly H1 receptors.
Levo
Y
Y
Harbeck
R J
RJ
Kirkpatrick
C H
CH
D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002744:Chlorpheniramine / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects; D011043:Pokeweed Mitogens / Q000494:pharmacology; D011969:Receptors, Histamine H1 / Q000187:drug effects / Q000502:physiology
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D007074:Immunoglobulin G; D011043:Pokeweed Mitogens; D011969:Receptors, Histamine H1; D007073:Immunoglobulin E; D002744:Chlorpheniramine; D002927:Cimetidine; D006632:Histamine