Vaccination of rabbits against Entamoeba histolytica with aqueous suspensions of trehalose-dimycolate as the adjuvant.
Rabbits were immunized with soluble Entamoeba histolytica antigen with an aqueous suspension of trehalose-6,6'-dimycolate used as the adjuvant. Induction of protective immunity in the immunized animals was demonstrated by enhanced humoral and cell-mediated immune responses and 100% survival after challenge. Administration of soluble antigen only failed to induce a similar degree of protective immunity. Trehalose-6,6'-dimycolate alone produced only a slight increase in nonspecific resistance.
Sharma
A
A
Haq
A
A
Ahmad
S
S
Lederer
E
E
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000953:Antigens, Protozoan / Q000276:immunology*; D003311:Cord Factors / Q000494:pharmacology*; D004748:Entamoeba histolytica / Q000276:immunology*; D004749:Entamoebiasis / Q000276:immunology; D006017:Glycolipids / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D011817:Rabbits; D013535:Suspensions; D014611:Vaccination
D000276:Adjuvants, Immunologic; D000953:Antigens, Protozoan; D003311:Cord Factors; D006017:Glycolipids; D013535:Suspensions