Centrally administered hypothalamic growth hormone-releasing factor stimulates food intake in free-feeding rats.
Intracerebroventricular injections of rat hypothalamic growth hormone-releasing factor (rhGRF) were examined for effects on food intake in free-feeding rats. It was found that, in picomole doses, rhGRF had a stimulatory effect on food intake. Examination of higher doses of rhGRF revealed a decrease in the facilitatory effects and an inhibitory trend at the highest dose (4 nanomoles). The present results are consistent with previous results from our laboratory showing that central injections of rhGRF stimulate food intake in food-deprived rats.
Vaccarino
F J
FJ
University of Toronto, Department of Psychology, Ontario, Canada.
Feifel
D
D
Rivier
J
J
Vale
W
W
Koob
G F
GF
D000818:Animals; D005247:Feeding Behavior / Q000187:drug effects*; D013007:Growth Hormone-Releasing Hormone / Q000008:administration & dosage*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D013007:Growth Hormone-Releasing Hormone