Peptides as central regulators of feeding.
During the past decade there has been an increased awareness of the role peptides play as neuromodulators. In this article we review the available data on peptides as central regulators of food ingestion. We stress the possible problems of non-specific effects. We stress that whereas many peptides decrease feeding after central injection, only two families of peptides have been shown to increase feeding after central injection. These are the opioid family and the pancreatic polypeptide-neuropeptide Y family. The putative role of corticotropin releasing factor as the mediator of norepinephrine and serotonin effects on feeding is discussed.
Morley
J E
JE
Levine
A S
AS
Gosnell
B A
BA
Krahn
D D
DD
D029845:Amphibian Proteins; D000818:Animals; D001839:Bombesin / Q000502:physiology; D002116:Calcitonin / Q000008:administration & dosage; D015740:Calcitonin Gene-Related Peptide; D002108:Ceruletide / Q000008:administration & dosage; D002766:Cholecystokinin / Q000502:physiology; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage; D005247:Feeding Behavior / Q000187:drug effects*; D005934:Glucagon / Q000008:administration & dosage; D007276:Injections, Intraventricular; D007328:Insulin / Q000008:administration & dosage; D009419:Nerve Tissue Proteins / Q000008:administration & dosage / Q000502:physiology*; D009478:Neuropeptide Y; D009496:Neurotensin / Q000008:administration & dosage; D018377:Neurotransmitter Agents / Q000008:administration & dosage / Q000502:physiology*; D036361:Peptide Hormones; D010455:Peptides / Q000008:administration & dosage; D051381:Rats; D013004:Somatostatin / Q000008:administration & dosage; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage; D013997:Time Factors
D029845:Amphibian Proteins; D007328:Insulin; D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D018377:Neurotransmitter Agents; D036361:Peptide Hormones; D010455:Peptides; D009496:Neurotensin; D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone; C025727:sauvagine; D002108:Ceruletide; D002116:Calcitonin; D005934:Glucagon; D002766:Cholecystokinin; D003346:Corticotropin-Releasing Hormone; D015740:Calcitonin Gene-Related Peptide; D001839:Bombesin