Effect of the nonsedative H1-receptor antagonist astemizole in perennial allergic and nonallergic rhinitis.
We studied the efficacy and side effects of the H1-antihistamine astemizole in perennial rhinitis. We also defined subgroups of responders and examined the added effect of a steroid spray. Fifty-five adults completed a 10- to 14-week controlled trial. Astemizole reduced the number of sneezes to 41% (p less than 0.001) and the number of nose blowings to 55% (p less than 0.001) of the placebo values. The added use of beclomethasone dipropionate caused a further reduction to 14% (p less than 0.001) and 37% (p less than 0.05), respectively. Nasal blockage was only marginally affected by the antihistamine, but it was reduced to 64% by the steroid spray (p less than 0.001). "Sneezers" responded better to the antihistamine than "blockers," with "nose blowers" in an intermediate position. The effect was equal in allergic and nonallergic patients. Astemizole was completely nonsedative but increased appetite and body weight. An open 1-year study of 17 patients demonstrated that astemizole maintained its efficacy and that further weight gain did not occur. It is concluded that astemizole is a highly effective nonsedative H1-antihistamine suitable for continuous therapy of perennial rhinitis.
Wihl
J A
JA
Petersen
B N
BN
Petersen
L N
LN
Gundersen
G
G
Bresson
K
K
Mygind
N
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D016589:Astemizole; D001507:Beclomethasone / Q000009:adverse effects / Q000627:therapeutic use; D001562:Benzimidazoles / Q000009:adverse effects / Q000627:therapeutic use*; D002940:Circadian Rhythm / Q000187:drug effects; D002986:Clinical Trials as Topic; D005260:Female; D006634:Histamine H1 Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism; D012220:Rhinitis / Q000145:classification / Q000188:drug therapy*; D012221:Rhinitis, Allergic, Perennial / Q000145:classification / Q000188:drug therapy*; D012912:Sneezing / Q000187:drug effects; D013997:Time Factors
D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D016589:Astemizole; D001507:Beclomethasone