[Evaluation of the adequacy of hypotensive therapy based on the status of the tissue oxygen system and serum lactate dehydrogenase and cytochrome oxidase activities in patients with hypertension].
Parameters of tissue oxygen regime measured by polarography and serum lactate dehydrogenase (LDG) and cytochrome oxidase (CO), oxidation-reduction enzymes, were studied in 23 patients with stable hypertension of various hemodynamic types. The nature of the tissue oxygen regime and changes observed in the isoenzymic spectra of LDG and CO were found to be associated with BP levels, hemodynamic types and BP reduction degree. The time course of these values may be useful in assessing whether the antihypertensive therapy is appropriate and in determining an optimal level of BP decrease.
Kulichenko
L L
LL
Almazov
I I
II
Ponomarev
Iu A
IuA
Oshchepkova
E V
EV
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D003576:Electron Transport Complex IV / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects*
D000959:Antihypertensive Agents; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D003576:Electron Transport Complex IV
Otsenka adekvatnosti gipotenzivnoĭ terapii po sostoianiiu kislorodnogo rezhima tkaneĭ i aktivnosti laktatdegidrogenazy i tsitokhromoksidazy v syvorotke krovi u bol'nykh gipertonicheskoĭ bolezn'iu.