[Kinetics of the inactivation of tetrodotoxin-sensitive sodium channels in the spinal ganglion neurons of rats].
The assessment of TTX-sensitive sodium transmembrane ionic current induced by depolarizing shifts in the MP performed in neurons of isolated dorsal root ganglion of adult rats revealed that the kinetics of the inactivation of TTX-sensitive sodium channels was more complicated than suggested by Hodgkin and Huxley for gating devices, the behaviour of the inactivation system following at least two exponential kinetics.
Akoev
G N
GN
Kirov
S A
SA
Krylov
B V
BV
Podzorova
S A
SA
D000818:Animals; D003864:Depression, Chemical; D005727:Ganglia, Spinal / Q000187:drug effects*; D066298:In Vitro Techniques; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D010477:Perfusion / Q000379:methods; D051381:Rats; D011919:Rats, Inbred Strains; D015222:Sodium Channels / Q000187:drug effects*; D013779:Tetrodotoxin / Q000494:pharmacology*
D015222:Sodium Channels; D013779:Tetrodotoxin
Kinetika inaktivatsii tetrodotoksinchuvstvitel'nykh natrievykh kanalov neĭronov spinal'nykh gangliev krys.