title: Peri-incisional mezlocillin versus rectal-metronidazole for wound infection prophylaxis.
abstract: One hundred and forty patients who underwent appendicectomy were included in a prospective randomized trial to compare the ability of preoperative rectal metronidazole and peri-incisional mezlocillin to prevent wound infection following appendicectomy. The results show that bactericidal local tissue levels of mezlocillin were uniformly achieved using the peri-incisional technique. The wound infection rate for the metronidazole group was found to be 15.9% and did not significantly differ from the wound infection rate when mezlocillin was used (10.4%). Peri-incisional mezlocillin therefore appears to be a viable prophylactic technique against wound infection following appendicectomy and may offer a cheaper alternative to intravenous intra-operative metronidazole administration in cases when pre-operative metronidazole suppositories have been omitted. The peri-incisional mezlocillin technique is also suitable for routine prophylaxis against wound infection following appendicectomy.
authors.forename: C
authors.initials: C
authors.lastname: Porteous
authors.forename: P M
authors.initials: PM
authors.lastname: Davidson
authors.forename: D
authors.initials: D
authors.lastname: Rawluk
authors.forename: M
authors.initials: M
authors.lastname: Brown
authors.forename: R
authors.initials: R
authors.lastname: Scott
authors.forename: G
authors.initials: G
authors.lastname: Conn
authors.forename: A
authors.initials: A
authors.lastname: McClure
authors.forename: W R
authors.initials: WR
authors.lastname: Murray
mesh_terms: D000293:Adolescent; D000328:Adult; D001062:Appendectomy; D001442:Bacteroides Infections / Q000517:prevention & control; D001441:Bacteroides fragilis; D002648:Child; D002986:Clinical Trials as Topic; D004927:Escherichia coli Infections / Q000517:prevention & control; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008802:Mezlocillin / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011446:Prospective Studies; D011897:Random Allocation; D012007:Rectum; D013488:Suppositories; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D013488:Suppositories; D008795:Metronidazole; D008802:Mezlocillin