Immunohistochemical demonstration of catecholaminergic cell bodies in the spinal cord of the rat. Preliminary note.
In order to elucidate the anatomy of the spinal dopaminergic system, an immunohistochemical study using a tyrosine-hydroxylase (TH) antibody was undertaken in the rat. Intracisternal 6-hydroxydopamine (6-OHDA) injections were administered to destroy most of the noradrenergic fibres that descend to the spinal cord while preserving the dopaminergic fibres. The density of the remaining TH-like immunoreactive fibres was relatively low at all levels of the spinal cord; the highest density was observed in layers III, IV and X. In addition, we report the first evidence for the existence of TH-like immunoreactive cell bodies at definite levels (especially sacral) of the spinal cord.
Dietl
M
M
Arluison
M
M
Mouchet
P
P
Feuerstein
C
C
Manier
M
M
Thibault
J
J
D000818:Animals; D002395:Catecholamines / Q000032:analysis*; D006892:Hydroxydopamines / Q000494:pharmacology; D007124:Immunoenzyme Techniques; D008297:Male; D009412:Nerve Fibers / Q000201:enzymology*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology* / Q000201:enzymology; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis / Q000276:immunology
D002395:Catecholamines; D006892:Hydroxydopamines; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase