The effect of atracurium or fazadinium on intra-ocular pressure. A comparative study during induction of general anaesthesia.
The effect of atracurium 0.6 mg/kg (group A; n = 11) and fazadinium 1 mg/kg (group F; n = 11) on intraocular pressure (IOP) was investigated in 22 patients during induction of anaesthesia with thiopentone 4 mg/kg and fentanyl 0.015 mg/kg. IOP was significantly reduced (p less than 0.01) in all patients following induction of anaesthesia. Intubation produced a rise in IOP in all patients but this was not statistically significant and remained below pre-induction values. The changes were similar in each group. Both of these neuromuscular blockers appear suitable relaxants to use for intraocular surgery.
Tattersall
M P
MP
Manus
N J
NJ
Jackson
D M
DM
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001279:Atracurium; D005260:Female; D005283:Fentanyl; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D011726:Pyridinium Compounds / Q000494:pharmacology*; D013874:Thiopental
D007546:Isoquinolines; D009125:Muscle Relaxants, Central; D011726:Pyridinium Compounds; D001279:Atracurium; D013874:Thiopental; D005283:Fentanyl