Activation of Epstein-Barr virus in latently infected cell lines.
Several methods that can switch between latency and replication of Epstein-Barr virus (EBV) have been developed. These methods made it possible to identify and characterize the majority of virus proteins associated with the virus replication and to develop new assays for diagnosis. A possible activator protein encoded from the BamHI Z fragment of EBV genome, which can disrupt latency in EBV-genome positive cell lines, has also been identified. The developments in activation of the virus lytic cycle will be reviewed in this paper.
Luka
J
J
Department of Microbiology, Georgetown University Medical School, Washington, DC 20007.
D002460:Cell Line; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000254:growth & development* / Q000502:physiology; D006801:Humans; D014775:Virus Activation; D014779:Virus Replication