Comparison between glycopyrrolate and atropine in a mixture with neostigmine for reversal of neuromuscular blockade. Studies in patients following open heart surgery.
Atropine and glycopyrrolate were compared in a mixture with neostigmine for reversal of neuromuscular blockade in patients undergoing open heart surgery. In patients not receiving beta-blocking drugs, glycopyrrolate was shown to possess advantages over atropine in terms of a lower initial increase in heart rate, better protection against the muscarinic effects of neostigmine, and smaller increases in rate-pressure product. The concomitant administration of beta-adrenergic blocking therapy significantly attenuated the effect of reversal on heart rate and the differences between atropine and glycopyrrolate were not significant. There was no difference in the incidence of arrhythmias between patients who received beta-blocking drugs and those who did not.
Salem
M G
MG
Richardson
J C
JC
Meadows
G A
GA
Lamplugh
G
G
Lai
K M
KM
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D001285:Atropine / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D006348:Cardiac Surgical Procedures; D004338:Drug Combinations; D006024:Glycopyrrolate / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009388:Neostigmine / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects*; D010197:Pancuronium / Q000037:antagonists & inhibitors; D011759:Pyrrolidines / Q000494:pharmacology*; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D004338:Drug Combinations; D011759:Pyrrolidines; D009388:Neostigmine; D001285:Atropine; D010197:Pancuronium; D006024:Glycopyrrolate