title: Effects of clonixin, a non-steroidal analgesic, on the neurotransmission of the vas deferens of the rat.
abstract: 1. The effect of C1X on the responses to TNS, ACh and NE in the isolated rat vas deferens was studied. 2. C1X produced a significant reduction of muscular twitch induced by TNS. 3. The M1-ACh response was significantly increased by this non-steroidal analgesic. 4. The M2-ACh response was not changed by pre-treatment with C1X. 5. The alpha 1-NE response was not altered by C1X. 6. The alpha 2-NE response was potentiated by pre-treatment with C1X. 7. The findings suggest that C1X beside its ability to block the release of NE, has some common pharmacological properties, close to those of a "calcium modulator".
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Universidad de Chile, Santiago.
authors.forename: D
authors.initials: D
authors.lastname: Bustamante
authors.forename: H F
authors.initials: HF
authors.lastname: Miranda
authors.forename: C
authors.initials: C
authors.lastname: Paeile
authors.forename: W W
authors.initials: WW
authors.lastname: Wolstenholme
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003002:Clonixin / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000294:innervation*; D009539:Nicotinic Acids / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors; D014649:Vas Deferens / Q000294:innervation
chemical_list: D009539:Nicotinic Acids; D000109:Acetylcholine; D003002:Clonixin; D009638:Norepinephrine