title: Effect of methadone plus neuroleptics on treatment-resistant chronic paranoid schizophrenia.
abstract: In a placebo-controlled single-crossover study, seven patients with treatment-resistant chronic paranoid schizophrenia who received methadone plus neuroleptic showed significant improvement. Methadone may be a useful adjunctive treatment in a subpopulation of patients with chronic paranoid schizophrenia.
authors.forename: D A
authors.initials: DA
authors.lastname: Brizer
authors.forename: N
authors.initials: N
authors.lastname: Hartman
authors.forename: J
authors.initials: J
authors.lastname: Sweeney
authors.forename: R B
authors.initials: RB
authors.lastname: Millman
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D008875:Middle Aged; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales; D012563:Schizophrenia, Paranoid / Q000188:drug therapy* / Q000523:psychology
chemical_list: D014150:Antipsychotic Agents; D008691:Methadone