Adiphenine plasma levels and blood-brain barrier crossing in the rat.
Adiphenine was administered in 3H-labelled form in doses of 15 mumole/kg intravenously to male Wistar rats. Plasma and brain levels of the unchanged drug were measured. The elimination of the 3H-labelled compound from the plasma was monophasic with a half-life of 13 minutes. The unchanged drug was detectable in the plasma for 30 minutes after the injection. The time course of brain levels of unchanged drug paralleled that found in the plasma with a half-life of 9 to 12 minutes. In all experiments, brain and plasma levels of unchanged adiphenine correlate highly.
Michelot
J
J
Moreau
M F
MF
Veyre
A
A
Labarre
P
P
Meyniel
G
G
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004158:Diphenylacetic Acids / Q000097:blood* / Q000378:metabolism; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004158:Diphenylacetic Acids