title: Feasibility of prenatal diagnosis of beta-thalassaemia with synthetic DNA probes in two Mediterranean populations.
abstract: A feasibility study in two Mediterranean populations showed that prenatal diagnosis of beta-thalassaemia with a limited number of synthetic oligonucleotide probes would have been possible in about 70% of cases. To provide a comprehensive programme of prenatal diagnosis for the thalassaemias it would be necessary, in most populations, to combine fetal DNA analysis with fetal blood sampling and globin-chain synthesis studies.
authors.forename: S L
authors.initials: SL
authors.lastname: Thein
authors.forename: J S
authors.initials: JS
authors.lastname: Wainscoat
authors.forename: J M
authors.initials: JM
authors.lastname: Old
authors.forename: M
authors.initials: M
authors.lastname: Sampietro
authors.forename: G
authors.initials: G
authors.lastname: Fiorelli
authors.forename: R B
authors.initials: RB
authors.lastname: Wallace
authors.forename: D J
authors.initials: DJ
authors.lastname: Weatherall
mesh_terms: D001345:Autoradiography; D001483:Base Sequence; D003535:Cyprus; D005260:Female; D005813:Genes, Synthetic; D005914:Globins / Q000235:genetics*; D006801:Humans; D007558:Italy; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000235:genetics*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013789:Thalassemia / Q000175:diagnosis* / Q000235:genetics
chemical_list: D009841:Oligonucleotides; D005914:Globins