title: Action of uric acid, allopurinol and oxypurinol on the myeloperoxidase-derived oxidant hypochlorous acid.
abstract: Both oxypurinol and uric acid react with the myeloperoxidase-derived oxidant hypochlorous acid at physiological pH, and they can protect the elastase-inhibitory capacity of human alpha 1-antiprotease against inactivation by hypochlorous acid. Allopurinol does not protect alpha 1-antiprotease, possibly because the redox potential of allopurinol at physiological pH is too positive to permit oxidation by hypochlorous acid.
authors.affiliation: Department of Biochemistry, King's College (KQC), Strand Campus, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Grootveld
authors.forename: B
authors.initials: B
authors.lastname: Halliwell
authors.forename: C P
authors.initials: CP
authors.lastname: Moorhouse
mesh_terms: D000493:Allopurinol; D005609:Free Radicals; D006997:Hypochlorous Acid; D010084:Oxidation-Reduction; D010117:Oxypurinol; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D009195:Peroxidase; D011743:Pyrimidines; D014527:Uric Acid
chemical_list: D005609:Free Radicals; D011743:Pyrimidines; D014527:Uric Acid; D000493:Allopurinol; D006997:Hypochlorous Acid; D009195:Peroxidase; D010196:Pancreatic Elastase; D010117:Oxypurinol