title: The influence of electroshock on adrenoceptor function in rat brain cerebral cortex: selectivity for the alpha-adrenoceptor site.
abstract: The present study was undertaken to examine the effect of electroshock on adrenoceptor-mediated cAMP and inositol phosphate accumulation in rat brain cerebral cortical slices. Under the conditions of these experiments, isoproterenol-induced cAMP accumulation was unaltered by electroshock, although there was a significant reduction in the norepinephrine- and isoproterenol + 6-fluoronorepinephrine-stimulated responses. No change in alpha-adrenoceptor-mediated inositol phosphate accumulation was noted. The results indicate that electroshock selectively modifies an alpha-adrenoceptor system in brain that differs from that associated with inositol phosphate accumulation.
authors.affiliation: Institute of Pharmacology, Polish Academy of Sciences, Kracow, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Pilc
authors.forename: E
authors.initials: E
authors.lastname: Chalecka-Franaszek
authors.forename: I
authors.initials: I
authors.lastname: Nalepa
authors.forename: J
authors.initials: J
authors.lastname: Vetulani
authors.forename: S J
authors.initials: SJ
authors.lastname: Enna
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism; D004597:Electroshock; D007295:Inositol Phosphates / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*
chemical_list: D002395:Catecholamines; D007295:Inositol Phosphates; D011942:Receptors, Adrenergic, alpha; D000242:Cyclic AMP