title: [Role of benzodiazepine receptors in realizing the anxiolytic effect of compounds on intact rats and on animals with a physical dependence ethanol].
abstract: Anxiolytic activity of DSIP, sodium hydroxybutyrate, nicotinoyl-GABA, mebicar, some derivatives of aminoandrostane and beta-carboline was not, like in the case of diazepam and beta C-3CEE, related to benzodiazepine receptors. The degree of the decrease in anxiolytic activity of these compounds did not correspond to increasing Ki binding of 3H diazepam in alcoholic rats.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Burov
authors.forename: S N
authors.initials: SN
authors.lastname: Orekhov
authors.forename: R Iu
authors.initials: RIu
authors.lastname: Iukhananov
authors.forename: N N
authors.initials: NN
authors.lastname: Vedernikova
mesh_terms: D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003975:Diazepam / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D011963:Receptors, GABA-A; D003975:Diazepam
vernacular_title: Rol' benzodiazepinovykh retseptorov v realizatsii anksioliticheskogo éffekta soedineniĭ u intaktnykh krys i u zhivotnykh s fizicheskoĭ zavisimost'iu ot étanola.