title: Fibrolamellar carcinoma as a cause of bile duct obstruction.
abstract: Obstructive jaundice due to growth within bile ducts of hepatocellular carcinoma is uncommon and usually a manifestation of advanced, lethal tumour. We report a case of fibrolamellar carcinoma of the liver presenting with obstructive jaundice, caused by tumorous permeation of the left hepatic duct with migration of tumour fragments into the common bile duct. Immunocytochemical and ultrastructural features are described. Two and a half years after complete surgical resection the patient is free of tumour. The importance of accurate diagnosis of such tumours is emphasized.
authors.affiliation: Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
authors.forename: R P
authors.initials: RP
authors.lastname: Eckstein
authors.forename: C P
authors.initials: CP
authors.lastname: Bambach
authors.forename: D
authors.initials: D
authors.lastname: Stiel
authors.forename: J
authors.initials: J
authors.lastname: Roche
authors.forename: B N
authors.initials: BN
authors.lastname: Goodman
mesh_terms: D000293:Adolescent; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000473:pathology / Q000648:ultrastructure; D001651:Cholestasis, Extrahepatic / Q000209:etiology*; D002780:Cholestasis, Intrahepatic / Q000209:etiology*; D005340:Fibrinogen / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D000515:alpha 1-Antitrypsin; D005340:Fibrinogen