title: Differential effect of kainic acid on somatostatin, GABAergic and cholinergic neurons in the rat striatum.
abstract: Kainic acid was injected into the rat striatum and its effects on presumptive striatal cholinergic, GABAergic and somatostatin-containing neurons were examined with three histochemical staining methods. Presumptive cholinergic and GABAergic neurons are damaged to a similar extent, but somatostatin neurons are more sensitive to the neurotoxic effect of kainic acid and are more severely affected.
authors.forename: M
authors.initials: M
authors.lastname: Araki
authors.forename: P L
authors.initials: PL
authors.lastname: McGeer
authors.forename: E G
authors.initials: EG
authors.lastname: McGeer
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002799:Cholinergic Fibers / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D009252:NADPH Dehydrogenase / Q000378:metabolism; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D013004:Somatostatin / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D011759:Pyrrolidines; D013004:Somatostatin; D005680:gamma-Aminobutyric Acid; D009252:NADPH Dehydrogenase; D000612:4-Aminobutyrate Transaminase; D000110:Acetylcholinesterase; D007608:Kainic Acid