Marrow uptake of galactosyl-containing neoglycoproteins: implications in stem cell homing.
Tissue distribution of synthetic neoglycoproteins was studied after intravenous injection of 125I-labeled galactosyl-, mannosyl- and fucosyl-BSA. The highest uptake of all three reagents occurred in the bone marrow. Spleen also took up considerable proportions of galactosyl and mannosyl reagents, while liver only took up galactosyl-BSA. Implication of these findings in the recognition and homing of intravenously transplanted hemopoietic cells to bone marrow is discussed.
Aizawa
S
S
Veterans Administration Medical Center, Jackson, Mississippi 39216.
Tavassoli
M
M
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism*; D001854:Bone Marrow Cells; D005690:Galactose / Q000493:pharmacokinetics*; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D007202:Indicators and Reagents; D007262:Infusions, Intravenous; D051379:Mice; D008810:Mice, Inbred C57BL; D011956:Receptors, Cell Surface / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D007202:Indicators and Reagents; D011956:Receptors, Cell Surface; C039136:bovine serum albumin-galactose (39); C039707:galactose receptor; D012710:Serum Albumin, Bovine; D005690:Galactose