Iontophoretic administration of pirprofen or lysine soluble aspirin in the treatment of rheumatic diseases.
A double-blind study was designed to compare the efficacy and tolerability of pirprofen and lysine soluble aspirin administered by iontophoresis to 80 patients with various painful rheumatic diseases. Treatment lasted two weeks, with five administrations a week, each lasting 20 minutes (direct current; mean intensity, 2.3 mA). After five administrations, patients showed significant improvement in pain at rest and on movement, with no significant differences between pirprofen and aspirin. Final results were excellent or good in about 75% of the patients treated and functional improvement was satisfactory in about 80%. There were no side effects.
Garagiola
U
U
Ciba-Geigy S.p.A., Medical Department, Origgio (VA), Italy.
Dacatra
U
U
Braconaro
F
F
Porretti
E
E
Pisetti
A
A
Azzolini
V
V
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007478:Iontophoresis; D008239:Lysine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D009068:Movement; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010666:Phenylpropionates / Q000008:administration & dosage* / Q000009:adverse effects; D012216:Rheumatic Diseases / Q000150:complications / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates; D008239:Lysine; D001241:Aspirin; C008924:pirprofen; C010395:acetylsalicylic acid lysinate