Pertussis immunization of infants using a new combined DTP-polio vaccine.
As part of the evaluation of a new combined Diphtheria-Tetanus-Pertussis-Poliomyelitis (DTP-Polio) inactivated vaccine, the pertussis agglutinin response was studied in 62 infants, two to three months old. Each dose of vaccine combined these antigens in a 0.5 ml volume, and contained at least four International Protective Units of pertussis antigen adsorbed on aluminium hydroxide. Infants were vaccinated with three doses of DTP-Polio vaccine at two month intervals. Pertussis agglutinin determinations showed a satisfactory response after two DTP-Polio vaccine doses. Although higher agglutinin titres were apparent after three doses than after two, no significant difference was observed in the seroconversion rate after two or three doses (88.8% and 96.3% respectively). The DTP-Polio vaccine would thus seem suitable for use in a two-dose primary immunization schedule against pertussis.
Drucker
J
J
Schatzmayr
H
H
Grenier
B
B
Ajjan
N
N
Peyron
L
L
Roumiantzeff
M
M
D000373:Agglutinins / Q000032:analysis; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001886:Bordetella pertussis / Q000276:immunology; D004168:Diphtheria Toxoid / Q000008:administration & dosage*; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004306:Dose-Response Relationship, Immunologic; D004334:Drug Administration Schedule; D004338:Drug Combinations / Q000008:administration & dosage; D006801:Humans; D007114:Immunization; D007223:Infant; D010567:Pertussis Vaccine / Q000008:administration & dosage*; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage*; D013745:Tetanus Toxoid / Q000008:administration & dosage*; D014917:Whooping Cough / Q000276:immunology*
D000373:Agglutinins; D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations; D010567:Pertussis Vaccine; D011054:Poliovirus Vaccine, Inactivated; D013745:Tetanus Toxoid