Prolactin is a tumor promoter in rat liver.
Since prolactin, like the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate, induces ornithine decarboxylase and plasminogen activator activities, biochemical markers of a trophic response, this hormone might likewise promote neoplasia. To test this theory, rats were initiated with a hepatocarcinogen followed by six weeks of ovine prolactin. This regimen caused hepatomegaly and the development of enzyme-altered foci. Promotion with prolactin for 23 weeks further increased the numbers of enzyme-altered foci. We suggest that prolactin is an endogenous tumor promoter for chemically initiated cells.
Buckley
A R
AR
Putnam
C W
CW
Russell
D H
DH
D000818:Animals; D004790:Enzyme Induction; D005260:Female; D006529:Hepatomegaly / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced*; D009955:Ornithine Decarboxylase / Q000096:biosynthesis; D010960:Plasminogen Activators / Q000378:metabolism; D011388:Prolactin; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep; D013755:Tetradecanoylphorbol Acetate; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D011388:Prolactin; D005723:gamma-Glutamyltransferase; D010960:Plasminogen Activators; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate