Negative and deficit symptoms in schizophrenia do respond to neuroleptics.
Five large-scale placebo-controlled studies are cited to show that, contrary to the contention of Johnstone et al. (1976) and Crow (1980), negative and/or deficit symptoms in schizophrenia do indeed respond to neuroleptic treatment. Further evidence is given that it is the "organic-like" symptoms (visual and olfactory hallucinations, disorientation, and memory deficit) that do not respond to neuroleptics. This would more sensibly reformulate the hypothesis of Johnstone et al. (1976) and Crow (1980) to state that schizophrenic patients with enlarged ventricles tend to show symptoms of organicity and tend not to respond to neuroleptics.
Goldberg
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D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001143:Arousal / Q000187:drug effects; D006801:Humans; D007398:Interpersonal Relations; D019965:Neurocognitive Disorders / Q000188:drug therapy; D012559:Schizophrenia / Q000188:drug therapy*; D012562:Schizophrenia, Disorganized / Q000188:drug therapy; D012564:Schizophrenic Language; D012565:Schizophrenic Psychology; D012931:Social Environment; D014705:Verbal Behavior / Q000187:drug effects
D014150:Antipsychotic Agents