Solute conformation of enkephalin-like pentapeptides in deuterated dimethylsulphoxide.
NMR evidence of the temperature dependence of NH resonances and magnitudes of alpha-CH-NH couplings is advanced in support of preferred beta-bend conformations for five enkephalin-like pentapeptides as solutes in DMSO-d6. The relevance of these and related conformational studies to the interactions of peptides of the enkephalin class with opioid receptors is questioned.
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D000818:Animals; D003903:Deuterium; D004121:Dimethyl Sulfoxide; D004745:Enkephalins / Q000032:analysis* / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D013237:Stereoisomerism; D013696:Temperature
D004745:Enkephalins; D003903:Deuterium; D004121:Dimethyl Sulfoxide