title: Linkage analyses of multiple endocrine neoplasia, type 2 (MEN-2) with 23 classical genetic polymorphisms.
abstract: Linkage analyses were performed in a single large family with multiple endocrine neoplasia, type 2 (MEN-2) between 23 classical genetic polymorphisms and MEN-2. We exclude close linkage of the locus for MEN-2 with ABO, ACP1, BF, ESD, Fy, GALT, GLO1, Jk, MNSs, P, PGM1, Rh and TF, as well as absolute linkage with GPT. These results raise to about 6% the proportion of the genome that has been excluded in this one family. Somewhat positive lod scores were obtained for GC (0.92 at theta = 0), GPT (0.73 at theta = 0.1) and HP (1.49 at theta = 0.05); although not statistically significant, these findings suggest regions of the genome that warrant additional study.
authors.forename: S D
authors.initials: SD
authors.lastname: Kruger
authors.forename: J M
authors.initials: JM
authors.lastname: Gertner
authors.forename: R S
authors.initials: RS
authors.lastname: Sparkes
authors.forename: L E
authors.initials: LE
authors.lastname: Haedt
authors.forename: M
authors.initials: M
authors.lastname: Crist
authors.forename: M C
authors.initials: MC
authors.lastname: Sparkes
authors.forename: M
authors.initials: M
authors.lastname: Genel
authors.forename: K K
authors.initials: KK
authors.lastname: Kidd
mesh_terms: D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005799:Genes, Dominant; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D009377:Multiple Endocrine Neoplasia / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D011110:Polymorphism, Genetic