[Study of the hereditary differences in the cyclic nucleotide content of the blood serum in mice after exposure to stress and administration of phenazepam].
Blood plasma content of cAMP and cGMP in C57BL/6, BALB/c mice and their reciprocal F1-hybrids has been studied at rest, upon exposure to stress induced in an open field technique and phenazepam injection at a dose of 0.05 and 0.1 mg/kg. Interstrain differences in baseline content and changes of nucleotide concentration in conditions of stress have been revealed. F1-hybrids inherit initial correlation between nucleotide content and the type of cAMP changes of C57BL/6 mice and cGMP changes of BALB/c mice. Phenazepam injection to C57BL/6 and BALB/c mice was shown to produce specific shifts in blood plasma cyclic nucleotide content.
Seredinin
S B
SB
Badyshtov
B A
BA
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013312:Stress, Physiological / Q000235:genetics*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D000242:Cyclic AMP; D006152:Cyclic GMP
Izuchenie nasledstvennykh razlichiĭ v soderzhanii tsiklicheskikh nukleotidov v plazme krovi mysheĭ posle stressovykh vozdeĭstviĭ i vvedeniia fenazepama.