The effect of indoramin on plasma lipids in hypercholesterolemic patas monkeys.
In patas monkeys fed a high cholesterol diet, chronic dosing with the antihypertensive agent indoramin increases the cholesterol ratio by raising the plasma HDL-C concentration. Epidemiological evidence suggests that increasing HDL-C reduces the incidence of coronary heart disease (CHD). If, therefore, indoramin is able to evoke these changes in man it may be expected to favourably influence the progress of CHD.
Pierce
V
V
Shepperson
N B
NB
West-Watson
A
A
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004901:Erythrocebus patas; D005260:Female; D006937:Hypercholesterolemia / Q000097:blood*; D007211:Indoles / Q000494:pharmacology*; D007217:Indoramin / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D014280:Triglycerides / Q000097:blood
D007211:Indoles; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D007217:Indoramin; D002784:Cholesterol