Phosphonic analogues of excitatory amino acids raise the threshold for maximal electroconvulsions in mice.
2-Amino-5-phosphonopentanoic acid (100 and 200 mg/kg) and 2-amino-7-phosphonoheptanoic acid (50-200 mg/kg i.p.) significantly elevated the threshold for maximal electroconvulsions in mice, the latter being more effective in this respect. In contrast, neither alpha-aminoadipic acid nor L-glutamic acid diethyl ester (up to 200 and 400 mg/kg, respectively) offered any protection. The present results add further evidence to support the importance of the blockade of N-methyl-D-aspartic acid receptor-mediated events in the suppression of seizure activity.
Czuczwar
S J
SJ
Cavalheiro
E A
EA
Turski
L
L
Turski
W A
WA
Kleinrok
Z
Z
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives; D015074:2-Aminoadipic Acid / Q000627:therapeutic use*; D000596:Amino Acids / Q000627:therapeutic use*; D000600:Amino Acids, Dicarboxylic / Q000627:therapeutic use*; D000818:Animals; D004597:Electroshock; D005971:Glutamates / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D012640:Seizures / Q000209:etiology / Q000517:prevention & control*; D014633:Valine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000596:Amino Acids; D000600:Amino Acids, Dicarboxylic; D005971:Glutamates; C011829:glutamic acid diethyl ester; D015074:2-Aminoadipic Acid; D015763:2-Amino-5-phosphonovalerate; D014633:Valine; C031231:2-amino-7-phosphonoheptanoic acid