[Protein kinase C and regulation of specialized steroidogenic functions of the adrenal cortical cell].
Protein kinase C is expressed in adrenal cortex as a single isoenzyme, whereas four isoforms are detected in brain tissue. Of the two major steroidogenic agents (ACTH and angiotensin II), only A II stimulates polyphosphoinositide hydrolysis and thus appears able to induce protein kinase C activation in adrenocortical cell. Although direct activation of the kinase partly mimics the steroidogenic effect of A II, no clear evidence has been obtained for a monodirectional effect of the kinase in the acute activation of adrenocortical cell steroidogenic activity. On the other hand, protein kinase C may play a key role in multidirectional regulatory events, resulting in the modulation of ACTH-responsive adenylate cyclase activity, in feed-back control or subtle transregulation (cross-talk) processes between different adrenocortical cell activation pathways triggered by different hormonal signals.
Vilgrain
I
I
Laboratoire de Biochimie des Régulations Cellulaires Endocrines, INSERM U-244, LBIO, DRF, Centre d'Etudes Nucléaires, Grenoble.
Brami
B
B
Chambaz
E M
EM
D000302:Adrenal Cortex / Q000502:physiology*; D000305:Adrenal Cortex Hormones / Q000502:physiology*; D000324:Adrenocorticotropic Hormone / Q000502:physiology*; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000502:physiology; D002417:Cattle; D000242:Cyclic AMP / Q000502:physiology; D066298:In Vitro Techniques; D010703:Phorbol Esters / Q000494:pharmacology; D011493:Protein Kinase C / Q000502:physiology*
D000305:Adrenal Cortex Hormones; D001095:Arachidonic Acids; D010703:Phorbol Esters; D000804:Angiotensin II; D016718:Arachidonic Acid; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP; D011493:Protein Kinase C
Protéine-kinase C et régulations des fonctions différenciées stéroïdogéniques de la cellule corticosurrénale.