[Migraine and beta blocker. An overview].
Migraine is considered to be a primarily neurogenic disease. In this common headache syndrome beta-blockers are widely used as prophylactic drugs. In the meantime there is evidence for central beta-receptors. The effect of beta-blockers is considered to be based on a reduction of the increased sympathetic tonus and its influence on the intracerebral vessels. Beta-blockers--such as Atenolol, Metoprolol, Nadolol, Pindolol, Propranolol and Timolol which differ according to their intrinsic activity, their selectiv cardiac effects, their membran stabilizing ability, their hydro- or lipophily as well as according to their plasmaprotein binding capacity are used. Therefore, it is more likely that beta-blockers develop their effect through a stabilisation of the intrasynaptic serotonin-level in the serotonergic neurons of the brainstem.
Pfaffenrath
V
V
Pöllmann
W
W
Kufner
G
G
Drubba
S
S
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects; D002395:Catecholamines / Q000097:blood; D002560:Cerebrovascular Circulation / Q000187:drug effects; D000242:Cyclic AMP / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000503:physiopathology; D011453:Prostaglandins / Q000097:blood; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D012701:Serotonin / Q000097:blood; D013564:Sympathetic Nervous System / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D005230:Fatty Acids, Nonesterified; D011453:Prostaglandins; D011943:Receptors, Adrenergic, beta; D012701:Serotonin; D000242:Cyclic AMP
Migräne und Beta-Blocker. Eine Ubersicht.