title: Inhibition of macrophage chemotaxis by supernatant fluid from malignant cell lines.
abstract: The chemotactic locomotion of peritoneal macrophages in vitro was measured in the presence of supernatant fluid from 27 different tumour cell lines. All the tumour-derived cells tested caused profound depression of macrophage chemotaxis towards the chemo-attractant casein. Conversely, supernates from rapidly dividing non-malignant cells uniformly failed to depress macrophage migration. This confirms the results of a previous investigation and provides further evidence that malignant tumours depress the functions of the reticuloendothelial system of the host animal in vivo.
authors.affiliation: Department of Surgery, College of Medical Sciences, University of Calabar, Nigeria.
authors.forename: A A
authors.initials: AA
authors.lastname: Otu
mesh_terms: D000818:Animals; D002364:Caseins; D002460:Cell Line; D002461:Cell Line, Transformed; D002634:Chemotaxis, Leukocyte; D006801:Humans; D008262:Macrophage Activation; D008263:Macrophage Migration-Inhibitory Factors / Q000502:physiology*; D008264:Macrophages / Q000502:physiology; D009369:Neoplasms / Q000473:pathology* / Q000503:physiopathology
chemical_list: D002364:Caseins; D008263:Macrophage Migration-Inhibitory Factors