[Transport of univalent cations across the erythrocyte membrane of hypertensive rats of various ages].
In the erythrocytes incubated at low temperature (3-6 degrees C), the uptake of Li+ in 6- and 16-week old spontaneously hypertensive rats (SHR) was significantly higher than in the normotensive rats (WKY) of the same age. During the incubation of cells at 37 degrees C no difference occurred in either ouabain-sensitive or ouabain-resistant fluxes of Rb+, Na+ and Li+ between the 16-week old SHR and the WKY. K+ efflux from the erythrocytes at 3 degrees C was consistently stimulated after addition to the incubation medium of 1 mmol/l Ca2+. The value of Ca2+-dependent K+-transport was significantly elevated in 16-week old SHR than in the WKY, but there was no difference in 6-week old rats. Propranolol-induced Ca2+-dependent K+ efflux from the cells at 22 degrees C was markedly higher in 6- and 16-week old SHR as compared with the WKY. The results provide a further evidence in favor of the hypothesis on the existence of a "membrane defect" in red blood cells in the SHR.
Gusev
G P
GP
Skul'skiĭ
I A
IA
Khrusmaleva
R S
RS
D000375:Aging / Q000097:blood*; D000818:Animals; D001692:Biological Transport; D015220:Calcium Channels / Q000187:drug effects; D002414:Cations, Monovalent / Q000378:metabolism*; D003470:Culture Media; D004910:Erythrocyte Membrane / Q000378:metabolism*; D008094:Lithium / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012413:Rubidium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013696:Temperature
D015220:Calcium Channels; D002414:Cations, Monovalent; D003470:Culture Media; D008094:Lithium; D012964:Sodium; D011433:Propranolol; D012413:Rubidium; D011188:Potassium
Transport odnovalentnykh kationov cherez membranu éritrotsitov gipertenzivnykh kryz razlichnogo vozrasta.