title: Stress crack resistance of some pigmented and unpigmented tablet film coating systems.
abstract: Stress crack resistance parameters--tensile strength: Young's modulus ratio, relative surface energy, and toughness index--have been examined for unpigmented free films of hydroxypropyl methylcellulose containing polyvinyl alcohol, and polyethylene glycols 400 and 1000, as well as similar film systems pigmented with either talc or titanium dioxide. Incorporation of either polyvinyl alcohol or polyethylene glycols 400 and 1000 in hydroxypropyl methylcellulose film coatings eliminated the incidence of edge splitting in the coated tablets. Increase in pigment concentration generally led to a decrease in the crack resistance of pigmented films. There was a relation between the stress crack resistance of pigmented free films and the incidence of edge splitting of corresponding film coatings applied to aspirin tablets--generally, the higher the crack resistance the lower the incidence of edge splitting. A similar relationship applied to the unpigmented films only when the tensile strength: Young's modulus ratio was considered.
authors.forename: A O
authors.initials: AO
authors.lastname: Okhamafe
authors.forename: P
authors.initials: P
authors.lastname: York
mesh_terms: D001241:Aspirin; D006244:Hardness; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives; D011092:Polyethylene Glycols; D013608:Tablets, Enteric-Coated; D013627:Talc; D013718:Tensile Strength; D014025:Titanium
chemical_list: D013608:Tablets, Enteric-Coated; D013627:Talc; C009495:titanium dioxide; D065347:Hypromellose Derivatives; D011092:Polyethylene Glycols; D008747:Methylcellulose; D014025:Titanium; D001241:Aspirin