Cellular requirements for cutaneous sensitivity elicitation.
The role of glass-adherent cells in cutaneous sensitivity (CS) elicitation has been analyzed in this study. CS responses have been revealed to be mediated by at least two distinct subsets of genetically restricted T cells: I-restricted 'DTH-like' T cells and K/D-restricted 'CTL-like' T cells. Both T-cell responses require I-A-positive glass-adherent cell populations, which lack T-cell markers, to manifest their activities. The role of the adherent cells is different in the 'DTH-like' responses and the 'CTL-like' responses. The disparities between the present results and previous contentions are discussed in this paper.
Aoki
I
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Department of Pathology, Yokohama City University School of Medicine, Japan.
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000473:pathology; D002469:Cell Separation; D005898:Glass; D006183:H-2 Antigens / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000473:pathology; D007116:Immunization, Passive; D008264:Macrophages / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology / Q000637:transplantation
D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II