title: Experimental pyelonephritis in the monkey. VII. Ascending pyelonephritis in the absence of vesicoureteral reflux.
abstract: Six adult male nonrefluxing monkeys were experimentally infected by inoculation of P-fimbriated E. coli into the bladder. Eight control monkeys were inoculated with a non-P-fimbriated E. coli strain. Inoculation with the P-fimbriated E. coli resulted in marked leukocytosis, prolonged bacteriuria and loss of renal function with a 66 per cent incidence of pyelonephritis. Death secondary to bilateral pyelonephritis was seen in 2 monkeys inoculated with P-fimbriated E. coli. Pyelonephritis was not seen in any of the monkeys inoculated with non-P-fimbriated E. coli. The study shows that ascending pyelonephritis can occur in monkeys in the absence of vesicoureteral reflux.
authors.forename: J A
authors.initials: JA
authors.lastname: Roberts
authors.forename: G M
authors.initials: GM
authors.lastname: Suarez
authors.forename: B
authors.initials: B
authors.lastname: Kaack
authors.forename: G
authors.initials: G
authors.lastname: Kallenius
authors.forename: S B
authors.initials: SB
authors.lastname: Svenson
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D004926:Escherichia coli / Q000472:pathogenicity / Q000648:ultrastructure; D004927:Escherichia coli Infections / Q000503:physiopathology; D010861:Fimbriae, Bacterial / Q000502:physiology; D007668:Kidney / Q000473:pathology; D008297:Male; D011704:Pyelonephritis / Q000209:etiology / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology*; D001743:Urinary Bladder / Q000382:microbiology; D014718:Vesico-Ureteral Reflux / Q000150:complications / Q000503:physiopathology*