Efficacy of a new antihypertensive agent (indenolol) assessed by ambulatory blood pressure monitoring.
The effects of two-week treatment periods with indenolol (I) and metoprolol (M) were examined by 24-hour mean blood pressure (BP) monitoring in control conditions and during exercise stress test in 7 patients with essential hypertension, using the Oxford method. Both drugs induced a significant reduction in mean BP and heart rate (HR) as compared to pretreatment values (mean BP: from 117 +/- 3 mmHg to 106 +/- 4 after I, p less than 0.05 and to 102 +/- 3 after M, p less than 0.01; HR: from 78 +/- 2 bpm to 66 +/- 2 after I, p less than 0.01 and to 67 +/- 2 after M, p less than 0.01). I and M induced a significant reduction in systolic and diastolic BP throughout the day and most of the night. During bicycle ergometer the basal and peak values of systolic and diastolic BP were significantly lower after both treatments as compared to the pretreatment values (both p less than 0.01). Our data suggest that I once a day possesses a substantial and consistent antihypertensive action, effective over most of the 24 hours.
Trimarco
B
B
Groothold
G
G
Bonaduce
D
D
Cuocolo
A
A
Ricciardelli
B
B
Canonico
V
V
Breglio
R
R
Condorelli
M
M
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000553:Ambulatory Care; D001795:Blood Pressure Determination / Q000379:methods; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007192:Indenes / Q000627:therapeutic use*; D008790:Metoprolol / Q000627:therapeutic use; D008991:Monitoring, Physiologic; D011412:Propanolamines / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D007192:Indenes; D011412:Propanolamines; C002989:indenolol; D008790:Metoprolol