[Comparative effectiveness of the enteral and intravenous administration of rifampicin in treating experimental tuberculosis in rabbits].
The efficacy of intravenous and enteral administration of rifampicin was studied comparatively in treatment of hematogenic diseminated tuberculosis in rabbits. The drugs were administered in a dose of 10 mg/kg for 60 days. The functional state of the liver was studied in the time course by activity of urokinase, a hepatospecific enzyme and transaminases. Monotherapy with rifampicin capsules administered enterally resulted in death of 66.6 per cent of the animals due to tuberculosis during the first month of the treatment. Completion of the treatment course in 4 rabbits did not result in abacillation. When rifampicin was administered intravenously no deaths of the animals due to tuberculosis were recorded. Complete abacillation of the internal organs was observed in 37.5 per cent of the rabbits. The changes in activity of the indicator enzymes were transient and after discontinuation of the treatment came to normal.
Bondarev
I M
IM
Mozhokina
G N
GN
Novoselova
V P
VP
Kovaleva
L A
LA
D000284:Administration, Oral; D000818:Animals; D004353:Drug Evaluation, Preclinical; D007275:Injections, Intravenous; D008099:Liver / Q000201:enzymology / Q000473:pathology; D011817:Rabbits; D012293:Rifampin / Q000008:administration & dosage*; D013997:Time Factors; D000637:Transaminases / Q000378:metabolism; D014376:Tuberculosis / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D014559:Urocanate Hydratase / Q000378:metabolism
D000637:Transaminases; D014559:Urocanate Hydratase; D012293:Rifampin
Sravnitel'naia éffektivnost' énteral'nogo i vnutrivennogo vvedeniia rifampitsina pri lechenii éksperimental'nogo tuberkuleza u krolikov.