Variant multiple endocrine neoplasia I (MEN IBurin): further studies and non-linkage to HLA.
We have extended our study of an incomplete variant of multiple endocrine neoplasia Type I (MEN IBurin). In this syndrome, primary hyperparathyroidism and prolactin-secreting adenoma are common, with hormone-secreting pancreatic tumors being rarely seen. The recent localization of the prolactin structural gene to chromosome 6 made further investigation of linkage to HLA of particular interest. Results in 2 multigeneration families exclude close linkage to HLA. We cannot at this time draw any inference regarding linkage of MEN IBurin to the prolactin structural gene.
Bear
J C
JC
Briones-Urbina
R
R
Fahey
J F
JF
Farid
N R
NR
D000236:Adenoma / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D006961:Hyperparathyroidism / Q000235:genetics; D008285:Major Histocompatibility Complex; D008297:Male; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000235:genetics*; D010375:Pedigree; D010911:Pituitary Neoplasms / Q000235:genetics / Q000378:metabolism; D011388:Prolactin / Q000235:genetics / Q000378:metabolism
D006680:HLA Antigens; D011388:Prolactin