Susceptibility of Campylobacter pylori isolated from pediatric and adult patients to seven new quinolone antibiotics and nalidixic acid.
The susceptibility of 26 strains of Campylobacter pylori to 7 new quinolone antibiotics and nalidixic acid was determined. All strains were resistant to nalidixic acid. Difloxacin, A-56620, A-62254, and ciprofloxacin were equally effective against the test strains with MICs ranging from 0.06 to 2.0 micrograms/ml. Fleroxacin, amifloxacin, perfloxacin, and norfloxacin showed only moderate activity against C. pylori. The new quinolone agents, which are bactericidal, may prove useful in the eradication of C. pylori from the gastric mucosa.
Hupertz
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Department of Pediatrics, Case Western Reserve University, School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, Ohio.
Carr
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Czinn
S J
SJ
D000328:Adult; D002167:Campylobacter / Q000187:drug effects* / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology*
D015363:Quinolones; D009268:Nalidixic Acid