Effects of a somatostatin analogue (SMS 201-995) on hepatic and splenic reticulo-endothelial function in the rat.
The effects of a long acting somatostatin analogue, SMS 201-995, on reticulo-endothelial system (RES) activity were studied in rats. Administration of 2 micrograms SMS 201-995 subcutaneously twice a day for 7 days significantly increased the splenic and hepatic uptake of 99mTc-sulphur colloid and damaged 51mCr-red blood cells. Furthermore, SMS 201-995 administration significantly increased the plasma clearance of colloidal carbon as indicated by a lower area under the curve and an increased elimination constant. SMS 201-995 administration also significantly improved survival after intraperitoneal injection of Escherichia coli endotoxin. These results suggest that SMS 201-995 stimulates RES activity in rats. It is suggested that SMS 201-995 may be of value in stimulating RES activity in patients with cirrhosis and portal hypertension.
Baxter
J N
JN
Jenkins
S A
SA
Day
D W
DW
Shields
R
R
D000818:Animals; D002244:Carbon; D002860:Chromium Radioisotopes; D003102:Colloids; D004731:Endotoxins / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D008297:Male; D012157:Mononuclear Phagocyte System / Q000187:drug effects*; D015282:Octreotide; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects*; D013671:Technetium Tc 99m Sulfur Colloid
D002860:Chromium Radioisotopes; D003102:Colloids; D004731:Endotoxins; D013004:Somatostatin; D013671:Technetium Tc 99m Sulfur Colloid; D002244:Carbon; D015282:Octreotide