title: Drug-induced pulmonary disease. Part 2: Noncytotoxic drugs.
abstract: Nonchemotherapeutic drugs may also cause pulmonary parenchymal alterations. Mechanisms of pulmonary damage by these agents are diverse and may involve alterations of pulmonary homeostasis. Clinical features of noncytotoxic, drug-induced pulmonary disease are more heterogeneous than those associated with cytotoxic drugs, and several clinical syndromes are equally represented. Treatment and outcome vary with each individual drug and clinical presentation. In part 2, clinical and pathogenic aspects of noncytotoxic, drug-induced pulmonary disease are discussed.
authors.forename: J A
authors.initials: JA
authors.lastname: Cooper
authors.forename: D A
authors.initials: DA
authors.lastname: White
authors.forename: R A
authors.initials: RA
authors.lastname: Matthay
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects / Q000503:physiopathology; D004198:Disease Susceptibility; D004232:Diuretics / Q000009:adverse effects / Q000494:pharmacology; D004342:Drug Hypersensitivity / Q000209:etiology; D064420:Drug-Related Side Effects and Adverse Reactions; D005109:Extracellular Matrix / Q000187:drug effects; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced; D008168:Lung / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D009294:Narcotics / Q000009:adverse effects / Q000494:pharmacology; D010084:Oxidation-Reduction; D010447:Peptide Hydrolases / Q000378:metabolism; D011480:Protease Inhibitors / Q000378:metabolism; D011654:Pulmonary Edema / Q000139:chemically induced / Q000503:physiopathology; D011859:Radiography; D012130:Respiratory Hypersensitivity / Q000139:chemically induced; D012306:Risk; D013566:Sympathomimetics / Q000009:adverse effects / Q000494:pharmacology
chemical_list: D000889:Anti-Arrhythmia Agents; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D014150:Antipsychotic Agents; D004232:Diuretics; D009294:Narcotics; D011480:Protease Inhibitors; D013566:Sympathomimetics; D010447:Peptide Hydrolases