Self-mutilation in Lesch-Nyhan disease is caused by dopaminergic denervation.
Goldstein
M
M
Anderson
L T
LT
Reuben
R
R
Dancis
J
J
D000293:Adolescent; D002986:Clinical Trials as Topic; D004298:Dopamine / Q000502:physiology*; D004311:Double-Blind Method; D005476:Fluphenazine / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007926:Lesch-Nyhan Syndrome / Q000503:physiopathology*; D008297:Male; D012652:Self Mutilation / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*
D005476:Fluphenazine; D004298:Dopamine