Somatostatin-sensitive neural system in the liver.
An intraportal bolus injection of cyclic somatostatin in a dose of 3.05 pmol significantly increased the vagal afferent discharge rate in the rat. The results indicate that somatostatin facilitates the vagal sensory nerve activity in the portal venous area. The present immunohistochemical examination of the rat hepatic neural system further disclosed the encapsulated corpuscles which showed intense staining for exogenous somatostatin. They were located beneath the endothelium of the large branches of the portal vein, protruded into the lumen and contained terminal nerve arborizations in the core.
Nakabayashi
H
H
Niijima
A
A
Kurata
Y
Y
Usukura
N
N
Takeda
R
R
D000818:Animals; D007275:Injections, Intravenous; D008297:Male; D009411:Nerve Endings / Q000187:drug effects; D011169:Portal Vein / Q000294:innervation*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014630:Vagus Nerve / Q000033:anatomy & histology / Q000187:drug effects*
D013004:Somatostatin