Relation between aryl hydrocarbon hydroxylase inducibility, serum gamma-glutamyltransferase and serum cholesterol in middle-aged smokers and non-smokers.
Aryl hydrocarbon hydroxylase (AHH) inducibility, carbon monoxide in expired air (CO), serum gammaglutamyl-transferase (GGT), and total cholesterol were compared in equal-sized, age-matched samples of healthy middle-aged males born in 1921, 1934-1936, and 1946 attending the ongoing preventive medical population program in Malmö. AHH did not differ in various age - and smoking or non-smoking groups, and there were no correlations between AHH, GGT, and cholesterol. The findings provide evidence against the recent hypothesis that low cholesterol may mediate or reflect a carcinogenic mechanism through a state of general enzyme induction in the body.
Trell
L
L
Korsgaard
R
R
Janzon
L
L
Laurell
P
P
Petersson
B
B
Trell
E
E
D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis*; D002248:Carbon Monoxide / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D004790:Enzyme Induction / Q000187:drug effects; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology; D012907:Smoking; D013548:Sweden; D005723:gamma-Glutamyltransferase / Q000097:blood*
D008748:Methylcholanthrene; D002248:Carbon Monoxide; D002784:Cholesterol; D001189:Aryl Hydrocarbon Hydroxylases; D005723:gamma-Glutamyltransferase