Effect of paf-acether on isoprenaline-induced relaxation in isolated tracheal segments of rats and guinea pigs.
Platelet activating factor (paf-acether) was found to contract rat and guinea pig tracheal segments. It does not cause down regulation of beta-adrenoceptor in guinea pig trachea. In addition, paf-contracted rat tracheal segments lose their ability to relax in response to isoprenaline.
Chand
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Department of Pharmacology, Wallace Laboratories, Division of Carter-Wallace, Inc., Cranbury, NJ 08512.
Diamantis
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W
Sofia
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RD
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D010972:Platelet Activating Factor / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D014132:Trachea / Q000187:drug effects*
D010972:Platelet Activating Factor; D011943:Receptors, Adrenergic, beta; D002217:Carbachol; D007545:Isoproterenol