Sjögren-like syndrome after drug-induced toxic epidermal necrolysis.
7 of 9 patients recovering from a drug-induced toxic epidermal necrolysis (TEN) which they had had 2 months to 4 years before had xerostomia, or keratoconjunctivitis sicca, or both. 5 patients had symptoms; 2 had severe visual impairment. In 5 cases there was lymphocytic infiltration of small salivary glands; in 2 patients this was identical to that of Sjögren syndrome. None of the patients had antinuclear antibody. TEN may occur during acute graft-versus-host disease (GVHD) and these observations are reminiscent of the sicca syndromes reported during chronic GVHD. They suggest that autoimmune mechanisms may be involved in drug-induced TEN and that Sjögren syndrome may occur as the result of a drug reaction.
Roujeau
J C
JC
Phlippoteau
C
C
Koso
M
M
Wechsler
J
J
Andre
C
C
Binaghi
M
M
Revuz
J
J
Touraine
R
R
D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005128:Eye Diseases / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012469:Salivary Glands / Q000473:pathology; D012859:Sjogren's Syndrome / Q000209:etiology* / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000473:pathology