title: Role of the senile plaque in neuropeptide deficits of Alzheimer's disease.
abstract: Senile plaques participate in a cropping of the dendritic tree of enkephalinergic dentate granule cells and hl and subicular pyramidal cells. Somatostatin-containing pyramidal neurons are lost in Alzheimer's disease, whereas nonpyramidal somatostatin neurons are less affected. Fibers containing somatostatin penetrate immature, but not end-stage senile plaques. The senile plaque may precipitate much of the hippocampal denervation seen in Alzheimer's disease.
authors.forename: H K
authors.initials: HK
authors.lastname: Kulmala
authors.forename: J T
authors.initials: JT
authors.lastname: Hutton
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D004745:Enkephalins / Q000378:metabolism; D006801:Humans; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism
chemical_list: D004745:Enkephalins; D009419:Nerve Tissue Proteins; D013004:Somatostatin