Doxorubicin (adriamycin)-induced cardiotoxicity in turkey poults: an animal model.
Doxorubicin (adriamycin, ADR)-induced cardiomyopathy was produced in turkey poults in a period of 3 weeks. The cardiotoxicity is characterized by electrocardiographic changes, alterations in ultrastructural morphology, ventricular dilatation, a significantly increased number of heterophils, and significant decreases in body and heart weights, dry heart weight to body weight ratios, and number of non-granulocytic leukocytes. The turkey poult is a cost-effective model system for evaluating cardiotoxic effects of anthracycline drugs.
Czarnecki
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D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000633:toxicity*; D004562:Electrocardiography; D006331:Heart Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000648:ultrastructure; D009929:Organ Size / Q000187:drug effects; D014422:Turkeys
D004317:Doxorubicin