title: Association of ethylene-oxide-induced IgE antibodies with symptoms in dialysis patients.
abstract: IgE-type antibodies to human serum albumin/ethylene oxide conjugates were determined in 153 patients (140 unselected, 13 selected for presence of eosinophilia) on regular dialysis treatment by radioallergosorbent test (RAST) techniques. In 10.7% of unselected patients and 30.8% of selected patients, RAST values suggested ethylene oxide sensitisation. High RAST values were commonly associated with anaphylactoid reactions during dialysis and with chronic asthma. Ethylene oxide antibodies should be sought routinely in patients presenting with these symptoms and the necessity of ethylene oxide sterilisation of disposable dialysis equipment should be re-evaluated.
authors.forename: K W
authors.initials: KW
authors.lastname: Rumpf
authors.forename: S
authors.initials: S
authors.lastname: Seubert
authors.forename: A
authors.initials: A
authors.lastname: Seubert
authors.forename: H D
authors.initials: HD
authors.lastname: Lowitz
authors.forename: R
authors.initials: R
authors.lastname: Valentin
authors.forename: H
authors.initials: H
authors.lastname: Rippe
authors.forename: H
authors.initials: H
authors.lastname: Ippen
authors.forename: F
authors.initials: F
authors.lastname: Scheler
mesh_terms: D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced; D000906:Antibodies / Q000032:analysis; D001249:Asthma / Q000209:etiology / Q000276:immunology; D004342:Drug Hypersensitivity / Q000209:etiology / Q000276:immunology; D005027:Ethylene Oxide / Q000009:adverse effects / Q000276:immunology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects; D011863:Radioimmunoassay; D006435:Renal Dialysis / Q000009:adverse effects; D012709:Serum Albumin / Q000276:immunology; D013242:Sterilization / Q000379:methods
chemical_list: D000906:Antibodies; D012709:Serum Albumin; D007073:Immunoglobulin E; D005027:Ethylene Oxide