title: [In vitro activity of ceftriaxone on hospital bacteria. Results of a multicenter study].
abstract: Minimal inhibitory concentrations (MICs) of ceftriaxone were determined by agar dilution for 2 099 strains isolated in six teaching hospitals. MICs were less than 1 microgram/ml for the great majority of Enterobacteriaceae, with mode MICs varying across groups from less than 0.008 micrograms/ml for Proteus (mirabilis and indole-positive) to 0.25 for Enterobacter. Only a few resistant strains were found, mainly among Enterobacter and Citrobacter. Ceftriaxone proved noticeably less active against P. aeruginosa and Acinetobacter (mode MICs: 16 micrograms/ml). Haemophilus sp. and Gonococci, regardless of beta-lactamase production status, as well as Neisseria meningitidis, were highly susceptible (MIC less than 0.008-0.032). Ceftriaxone was moderately active against methicillin-susceptible staphylococci (MIC: 2 to 8 micrograms/ml) and failed to inhibit methicillin resistant strains. Enterococci were slightly susceptible or resistant, whereas the other Streptococci and Pneumococci had low MICs (0.03-0.25). A fairly wide range of MICs was found for anaerobes (Clostridium: 0.06-2, Bacteroides: 0.5-32). Our data show that its particularly strong activity against Proteus, Haemophilus and Neisseria sets ceftriaxone apart from the other third-generation cephalosporins.
authors.forename: C J
authors.initials: CJ
authors.lastname: Soussy
authors.forename: L
authors.initials: L
authors.lastname: Deforges
authors.forename: J
authors.initials: J
authors.lastname: Le Van Thoi
authors.forename: M
authors.initials: M
authors.lastname: Chanal
authors.forename: D
authors.initials: D
authors.lastname: Sirot
authors.forename: J F
authors.initials: JF
authors.lastname: Acar
authors.forename: M D
authors.initials: MD
authors.lastname: Kitzis
authors.forename: A
authors.initials: A
authors.lastname: Thabaut
authors.forename: M
authors.initials: M
authors.lastname: Meyran
authors.forename: H
authors.initials: H
authors.lastname: Dabernat
mesh_terms: D000150:Acinetobacter / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D001441:Bacteroides fragilis / Q000187:drug effects; D002443:Ceftriaxone / Q000494:pharmacology*; D003016:Clostridium perfringens / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004755:Enterobacteriaceae / Q000187:drug effects; D006190:Haemophilus / Q000187:drug effects; D006784:Hospitals, Teaching; D008826:Microbial Sensitivity Tests; D009345:Neisseria meningitidis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
chemical_list: D002443:Ceftriaxone
vernacular_title: Activité in vitro de la ceftriaxone sur les bactéries hospitalières. Résultats d'une étude multicentrique.