[Comparative sensitivity of the somas and dendrites of pyramidal neurons of the hippocampus to glutamate, aspartate and GABA in isolated sections of rat brain].
Effect of glutamate, aspartate and GABA on antidromic population spike was examined in isolated hippocampal slices separately in the region of somata and dendrites of CA1 pyramidal neurons. The sensitivity of somata and apical dendrites to glutamate and aspartate was equal. The action of these drugs was never accompanied by desensitization. The sensitivity to GABA was higher in the dendrites then in the somata. The somata showed strong desensitization to GABA. In distal dendrites desensitization to GABA was absent.
Artemenko
D P
DP
Gerasimov
V D
VD
D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D003712:Dendrites / Q000187:drug effects; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid
Sravnitel'naia chuvstvitel'nost' som i dendritov piramidnykh neĭronov gippokampa k glutamatu, aspartatu i GAMK v izolirovannykh srezakh mozga krysy.