Photo-decomposition and metabolism of the phenothiazine drug perazine.
An ethanolic solution of perazine (Taxilan), degraded by photooxidation, was examined by HPLC and mass-spectroscopy. Identical degradation and oxidation products were found in vitro as reported to exist in vivo with the exception of perazine-N-oxide and 3-OH-perazine. The formation of the latter two metabolites seems to be bound to the cytochrome P-450 system. A direct, oxygen dependent formation of some metabolites is, however, suggested. Side-effects of phenothiazines such as contact allergies might be related to the formation of radicals or particular oxidation products.
Schley
J
J
D000818:Animals; D014150:Antipsychotic Agents / Q000378:metabolism*; D004355:Drug Stability; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D010464:Perazine / Q000378:metabolism*; D010777:Photochemistry; D013056:Spectrophotometry, Ultraviolet
D014150:Antipsychotic Agents; D007202:Indicators and Reagents; D010464:Perazine