[Interaction of beta-adrenergic agents with the plasma membranes of the myocardium].
The initial stage of interaction of beta-adrenomimetics and beta-adrenoblockers with specific membrane binding sites is characterized by different patterns of thermodynamic parameters. Administration of isadrin results in a decrease of entropy and enthalpy, which reflects the primary binding reaction and agonist-specific receptor isomerization to the conformational form activating adenylate cyclase. Anaprilin and alpheprol do not change the receptor conformation and participate only in the primary binding reaction which is marked by a decrease in enthalpy and a rise of entropy in the course of interaction of beta-adrenoblockers with specific membrane binding sites. The different patterns of thermodynamic parameters under the effect of beta-adrenomimetics and beta-adrenoblockers on plasma membranes are explained by the different influence of these substances on the mobility of membrane lipids, i.e. on the viscosity of plasma membranes.
Chekman
I S
IS
Budarin
L I
LI
Nurishchenko
N E
NE
Ivanov
L V
LV
Pogrebnoĭ
P V
PV
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000526:Alprenolol / Q000494:pharmacology; D000818:Animals; D002152:Calorimetry, Differential Scanning; D002462:Cell Membrane / Q000187:drug effects; D004347:Drug Interactions; D004578:Electron Spin Resonance Spectroscopy; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D008024:Ligands; D011433:Propranolol / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D008024:Ligands; D013566:Sympathomimetics; D000526:Alprenolol; D011433:Propranolol; D007545:Isoproterenol
Vzaimodeĭstvie beta-adrenergicheskikh sredstv s plazmaticheskimi membranami miokarda.