title: Hairy cell leukaemia occurring during phenytoin (diphenylhydantoin) treatment.
abstract: We describe the case of a patient who developed hairy cell leukaemia (leukaemic reticuloendotheliosis) during phenytoin treatment. Hairy cells were identified by fluorescence, phase contrast and electron microscopy; they contained tartrate-resistant acid phosphatase activity, formed rosettes with mouse but not sheep erythrocytes and bore monoclonal surface immunoglobulin. Because of the association of pseudo- and true lymphomas with phenytoin it is possible that this lymphoproliferative disorder arose as a result of the treatment with phenytoin, possibly in conjunction with sulthiame.
authors.forename: G M
authors.initials: GM
authors.lastname: Gyte
authors.forename: J E
authors.initials: JE
authors.lastname: Richmond
authors.forename: J R
authors.initials: JR
authors.lastname: Williams
authors.forename: J L
authors.initials: JL
authors.lastname: Atwood
mesh_terms: D000328:Adult; D001856:Bone Marrow Examination; D005260:Female; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000139:chemically induced*; D008214:Lymphocytes / Q000648:ultrastructure; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D010672:Phenytoin / Q000009:adverse effects*; D013843:Thiazines / Q000009:adverse effects
chemical_list: D013843:Thiazines; D010672:Phenytoin