Cocaine-like action of diphenhydramine in cat cerebral arteries.
Diphenhydramine (5.3 X 10(-7) M) significantly reduced the tritium efflux evoked by 10(-7) M tyramine from cat cerebral arteries preloaded with [3H]noradrenaline but not that brought about by 50 mM KCl. These results indicate the ability of diphenhydramine to block the amine neuronal uptake.
Balfagón
G
G
Marco
E J
EJ
D000818:Animals; D002415:Cats; D002536:Cerebral Arteries / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D004155:Diphenhydramine / Q000494:pharmacology*; D005260:Female; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000378:metabolism
D006632:Histamine; D004155:Diphenhydramine; D003042:Cocaine; D009638:Norepinephrine