title: A glycophospholipid covalently attached to the C-terminus of the Thy-1 glycoprotein.
abstract: The Thy-1 glycoprotein is a very abundant cell surface molecule of rat thymocytes and neuronal cells with the properties of a molecule that inserts into the lipid bilayer. The hydrophobicity is due to a glycophospholipid component covalently attached to the carboxy group of the C-terminal cysteine residue. The mature glycoprotein does not contain a stretch of hydrophobic amino acids that could traverse the membrane bilayer. These findings present a new mode of membrane attachment for a cell surface molecule that can mediate lymphokine release and cell division after cross-linking by antibodies.
authors.forename: A F
authors.initials: AF
authors.lastname: Williams
authors.forename: A G
authors.initials: AG
authors.lastname: Tse
mesh_terms: D000595:Amino Acid Sequence; D000954:Antigens, Surface; D001921:Brain / Q000276:immunology; D002241:Carbohydrates / Q000032:analysis; D006017:Glycolipids / Q000032:analysis*; D006801:Humans; D008051:Lipid Bilayers; D008214:Lymphocytes / Q000276:immunology; D010743:Phospholipids / Q000032:analysis*; D018800:Thy-1 Antigens; D013950:Thymus Gland / Q000276:immunology
chemical_list: D000954:Antigens, Surface; D002241:Carbohydrates; D006017:Glycolipids; D008051:Lipid Bilayers; D010743:Phospholipids; D018800:Thy-1 Antigens