Biliary excretion of [14C]taurocholate by rainbow trout (Salmo gairdneri) is stimulated at warmer acclimation temperature.
Sexually immature Shasta strain rainbow trout (Salmo gairdneri) of either sex were acclimated at 10, 14 or 18 degrees C for at least 4 weeks and plasma pharmacokinetics and biliary excretion of i.p. injected [14C]taurocholate (TC) examined in spinally transected or free-swimming fish, respectively. Plasma elimination half-lives but not absorption rate constants for [14C]TC (10 mumol/kg) were about two-fold reduced in 18 as compared to 10 or 14 degrees C acclimated fish. Distribution of [14C]TC to tissues other than plasma, liver, bile and small intestine was not different in 10, 14 or 18 degrees C acclimated free-swimming fish at 1 or 4 hr post-injection. Biliary excretion of [14C]TC (7.5-10 mumol/kg) at 1 hr post-injection was significantly higher in 14 and 18 as compared to 10 degrees C acclimated fish.
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D000064:Acclimatization; D000818:Animals; D001646:Bile / Q000378:metabolism*; D002250:Carbon Radioisotopes; D005704:Gallbladder / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D013656:Taurocholic Acid / Q000097:blood / Q000378:metabolism*; D013696:Temperature; D014337:Trout
D002250:Carbon Radioisotopes; D013656:Taurocholic Acid