[Oral vaccination with live attenuated rotavirus].
A randomized, double-blind trial was performed to assess serological response and clinical protection for acute gastroenteritis due to rotavirus in 103 children aged 6 to 18 months, after a single dose of RIT 4237 live attenuated bovine rotavirus vaccine or placebo. Seroconversion, determined by enzyme-linked immunoabsorbent assay (ELISA), was significantly greater in initially seronegative vaccines compared with control group (p less than 0.0001); clinical protection rate was low in this study group and it is therefore concluded that seroconversion by itself is not sufficient to measure vaccine efficacy.
Escobar Castro
H
H
Unidad de Gastroenterología, Hospital Ramón y Cajal, Madrid.
Perdomo Giraldi
M
M
Tamáriz-Martel Moreno
A
A
Suárez Cortina
L
L
D000914:Antibodies, Viral / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005759:Gastroenteritis / Q000382:microbiology / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D012401:Rotavirus / Q000276:immunology; D012400:Rotavirus Infections / Q000517:prevention & control*; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
D000914:Antibodies, Viral; C041165:RIT 4237 vaccine; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
Vacunaciíon oral con rotavirus vivo atenuado.