Cholic acids/salts as barriers to diffusing species: effect of pH.
Bile acids have been absorbed on a microporous polypropylene membrane and the diffusion of ionic and non-ionic compounds through the barriers obtained has been studied at different pH values. Results indicate that permeation rates are affected by environmental pH conditions and an explanation of this behaviour is proposed. This study represents an approach for a pH-controlled drug delivery system.
Alhaique
F
F
Memoli
A
A
Santucci
E
E
D002635:Chenodeoxycholic Acid; D002793:Cholic Acids; D003840:Deoxycholic Acid; D004058:Diffusion; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008567:Membranes, Artificial; D010539:Permeability; D011126:Polypropylenes; D012459:Salicylates
D002793:Cholic Acids; D008567:Membranes, Artificial; D011126:Polypropylenes; D012459:Salicylates; D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid