Paediatric gastroenteritis in the eastern Malaysian state of Sarawak: an epidemiological and clinical study.
Over a period of 2 months, 35 of 69 (51%) cases of juvenile diarrhoea studied in eastern Malaysia were associated with rotavirus excretion; rotavirus associated diarrhoea occurred most commonly in the 6-24 month age group. Polyacrylamide gel electrophoresis (PAGE) of genome ribonucleic acid showed that only 4 rotavirus electropherotypes could be detected. Of those, 2 predominated and 2 were detected only once each; one of these may have been a reassortment of the two predominant electropherotypes. Analysis of the clinical features of patients excreting rotavirus subgroup 1 or 2, determined by PAGE, demonstrated that rotavirus subgroup 1 was associated with more hypotonic dehydration and need for intravenous therapy: lethargy was significantly more common among those excreting rotavirus subgroup 2.
Barker
R A
RA
Department of Virology, St Thomas's Hospital, London, UK.
Maxwell
P H
PH
Hong
C P
CP
Cordery
M C
MC
Chrystie
I L
IL
D002675:Child, Preschool; D003681:Dehydration / Q000150:complications; D003967:Diarrhea / Q000453:epidemiology* / Q000382:microbiology; D003968:Diarrhea, Infantile / Q000453:epidemiology; D004591:Electrophoresis, Polyacrylamide Gel; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D008296:Malaysia; D008297:Male; D012401:Rotavirus / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000150:complications