title: Hemoglobin A2 Honai (alpha 2 delta 2(90)(F6)Glu----Val): a new delta chain variant.
abstract: A new slow-moving variant of hemoglobin(Hb) A2, designated as Hb A2 Honai, was found to have an amino acid substitution of valine for glutamic acid at position 90(F6) in the delta chain. Hb A2 Honai comprised 0.84% of total hemoglobin. Hb A2 and Hb A were estimated to be 1.30% and 97.85%, respectively. Hb A2 Honai was observed in 4 members of a family in 3 generations. No hematologic abnormalities were associated with Hb A2 Honai.
authors.forename: S
authors.initials: S
authors.lastname: Fujita
authors.forename: Y
authors.initials: Y
authors.lastname: Ohta
authors.forename: S
authors.initials: S
authors.lastname: Saito
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Naritomi
authors.forename: T
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: T
authors.initials: T
authors.lastname: Imamura
authors.forename: Y
authors.initials: Y
authors.lastname: Wada
authors.forename: A
authors.initials: A
authors.lastname: Hayashi
mesh_terms: D000368:Aged; D000596:Amino Acids / Q000032:analysis; D001797:Blood Protein Electrophoresis; D002851:Chromatography, High Pressure Liquid; D004592:Electrophoresis, Starch Gel; D005260:Female; D005971:Glutamates; D018698:Glutamic Acid; D006441:Hemoglobin A / Q000235:genetics*; D006443:Hemoglobin A2 / Q000235:genetics*; D006801:Humans; D010375:Pedigree; D010446:Peptide Fragments / Q000302:isolation & purification; D014633:Valine
chemical_list: D000596:Amino Acids; D005971:Glutamates; D010446:Peptide Fragments; C048109:hemoglobin A2 Honai; D018698:Glutamic Acid; D006441:Hemoglobin A; D006443:Hemoglobin A2; D014633:Valine