Differential effect of ethanol consumption on hamster liver microsomal electron transport systems.
The effect of 28-day ethanol consumption on hamster liver microsomal electron transport systems and associated enzymatic activities has been examined. Microsomes isolated from ethanol-consuming hamsters showed increased levels of cytochrome P-450 and NADPH supported enzymatic activities. In contrast, reductions in the amount of cytochrome b5 and the NADH-supported rate of stearoyl-CoA desaturase were observed. NADH-cytochrome c reductase was decreased while a small increase in NADH-ferricyanide reductase was observed. These data suggest that decreased stearoyl-CoA desaturase activity is the result of lowered cytochrome b5 levels in microsomes isolated from ethanol-consuming hamsters.
McCoy
G D
GD
Lobel
P
P
DeMarco
G J
GJ
D000818:Animals; D001692:Biological Transport; D006224:Cricetinae; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D003573:Cytochrome b Group / Q000032:analysis; D015786:Cytochromes b5; D004583:Electrons; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D008647:Mesocricetus; D008862:Microsomes, Liver / Q000187:drug effects*; D009245:NADH Dehydrogenase / Q000032:analysis; D009251:NADPH-Ferrihemoprotein Reductase / Q000032:analysis; D013230:Stearoyl-CoA Desaturase / Q000032:analysis
D003573:Cytochrome b Group; D000431:Ethanol; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D013230:Stearoyl-CoA Desaturase; D009251:NADPH-Ferrihemoprotein Reductase; D009245:NADH Dehydrogenase