title: Unrelated individuals matched for MHC extended haplotypes and HLA-identical siblings show comparable responses in mixed lymphocyte culture.
abstract: Extended haplotypes are specific HLA B, HLA DR, BF, C2, C4A, and C4B combinations in significant linkage disequilibrium in chromosomes of unrelated individuals. The possibility that matching unrelated individuals for extended haplotypes may match for the genes that cause mixed lymphocyte reactivity was tested. 22 of 26 unrelated extended-haplotype-matched subjects had similar mixed lymphocyte reactivity to HLA-identical siblings.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Awdeh
authors.forename: C A
authors.initials: CA
authors.lastname: Alper
authors.forename: E
authors.initials: E
authors.lastname: Eynon
authors.forename: S M
authors.initials: SM
authors.lastname: Alosco
authors.forename: R
authors.initials: R
authors.lastname: Stein
authors.forename: E J
authors.initials: EJ
authors.lastname: Yunis
mesh_terms: D000483:Alleles; D005260:Female; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006684:HLA-DR Antigens; D006238:Haploidy; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008285:Major Histocompatibility Complex; D008297:Male
chemical_list: D006680:HLA Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II