Significance of serum lipoprotein-X and gammaglutamyltranspeptidase in the diagnosis of biliary atresia. A preliminary study in 27 cholestatic young infants.
As simple and nonsurgical means of differentiating biliary atresia (BA) from intrahepatic cholestasis of unknown origin (IC), liver function tests including serum lipoprotein-X (LP-X) and gamma-glutamyltranspeptidase (GGTP) were done and evaluated for their usefulness in the diagnosis of 27 cholestatic Japanese young infants. Except for LP-X and GGTP levels (P less than 0.01, P less than 0.001), there were no significant differences between the BA (n = 11) and IC (n = 13) groups. When values of mean plus 4 standard deviations were used to differentiate BA from IC (89 mg/100 ml for LP-X and 194 IU/l for GGTP), all BA patients gave positive results for either the critical LP-X of GGTP values. On the other hand, all IC patients gave negative results for both levels, although patients with a paucity of intrahepatic biliary ducts (n = 3) were also positive for either the critical LP-X or GGTP values. The combination test with serum LP-X and GGTP is recommended for helping to differentiate BA from IC in cholestatic young infants.
Tazawa
Y
Y
Yamada
M
M
Nakagawa
M
M
Tada
K
K
Konno
T
T
Ohi
R
R
Kasai
M
M
D001652:Bile Ducts / Q000002:abnormalities*; D002780:Cholestasis, Intrahepatic / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008073:Lipoprotein-X / Q000097:blood*; D008297:Male; D005723:gamma-Glutamyltransferase / Q000097:blood*
D008073:Lipoprotein-X; D005723:gamma-Glutamyltransferase