title: Acute encephalopathy coincident with seroconversion for anti-HTLV-III.
abstract: Acute encephalopathy was associated with the appearance of antibodies to human T-lymphotropic virus (HTLV-III) in two patients. A third patient showed seroconversion for anti-HTLV-III, but the temporal association was not established so precisely. The illness was characterised by a prodromal period of up to 2 weeks, characterised by pyrexia, general malaise, and changes of mood. The encephalopathy culminated in epileptiform seizures in two of the patients. Electroencephalographic changes were compatible with viral encephalitis, and cerebrospinal-fluid pleocytosis was minimal. Neurological signs and symptoms resolved quickly in all patients, and no residual central-nervous-system sequelae were apparent.
authors.forename: C A
authors.initials: CA
authors.lastname: Carne
authors.forename: R S
authors.initials: RS
authors.lastname: Tedder
authors.forename: A
authors.initials: A
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Sutherland
authors.forename: S G
authors.initials: SG
authors.lastname: Elkington
authors.forename: H M
authors.initials: HM
authors.lastname: Daly
authors.forename: F E
authors.initials: FE
authors.lastname: Preston
authors.forename: J
authors.initials: J
authors.lastname: Craske
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology; D000208:Acute Disease; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D001927:Brain Diseases / Q000209:etiology* / Q000276:immunology; D017977:Deltaretrovirus / Q000276:immunology*; D004660:Encephalitis / Q000209:etiology / Q000276:immunology; D006716:Homosexuality; D006801:Humans; D008297:Male; D008875:Middle Aged; D012192:Retroviridae Infections / Q000150:complications / Q000276:immunology
chemical_list: D000914:Antibodies, Viral