title: Leech Retzius cells and 5-hydroxytryptamine.
abstract: A pair of giant Retzius (R) cells in each segmental ganglion of the leech contain 5-hydroxytryptamine (5-HT). They are the only 5-HT-containing neurones in the central nervous system to send branches to the periphery, yet many peripheral tissues (e.g. body wall muscles, heart, reproductive organs, nephridia and gut) possess 5-HT-like immunoreactive nerve fibres. 5-HT and/or R cell stimulation relax basal tension of body wall muscles and reduce their relaxation times following contraction, enhance pharyngeal movements and salivary gland secretion but inhibit muscle movements of the posterior gut regions and of the reproductive tract. It is suggested that R cells are multifunction neurones modulating activity of many tissues so that feeding behaviour of the leech is carried out as efficiently as possible.
authors.forename: L D
authors.initials: LD
authors.lastname: Leake
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D007865:Leeches / Q000378:metabolism*; D008124:Locomotion; D009119:Muscle Contraction; D009420:Nervous System / Q000166:cytology / Q000378:metabolism*; D009457:Neuroglia / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*
chemical_list: D012701:Serotonin