title: The effect of glass-ceramic bone implant materials on the in vitro formation of hydroxyapatite.
abstract: The extracts of four glass-ceramic bone implant materials were investigated for dissolved material, for effects on in vitro formation of hydroxyapatite, and for surface morphology of glass-ceramic particles in scanning electron microscopy. In vitro leaching released substances that affected in vitro formation of hydroxyapatite, i.e., initiation time and growth of crystals. Leaching also changed the surface morphology of the materials. The ability of the materials to bond to bone did not correlate with the inhibition of hydroxyapatite formation by the released substances. Surface morphology and other factors at present not yet known are probably involved in controlling the bonding to bone of these ceramics.
authors.affiliation: Department of Ultrastructural Biochemistry, Hospital for Special Surgery, Cornell University Medical College, New York, New York 10021.
authors.forename: N C
authors.initials: NC
authors.lastname: Blumenthal
authors.forename: A S
authors.initials: AS
authors.lastname: Posner
authors.forename: V
authors.initials: V
authors.lastname: Cosma
authors.forename: U
authors.initials: U
authors.lastname: Gross
mesh_terms: D001842:Bone and Bones; D002516:Ceramics; D017886:Durapatite; D005898:Glass; D006801:Humans; D006882:Hydroxyapatites; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D019736:Prostheses and Implants; D012972:Sodium Hydroxide; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D006882:Hydroxyapatites; D012972:Sodium Hydroxide; D017886:Durapatite