[Effect of neurotropic drugs on calmodulin and troponin C-dependent processes].
The effects of neurotropic compounds on Ca-binding proteins (calmodulin, troponin C) were investigated. It was shown that the majority of neuroleptics of the phenothiazine group effectively interact with the both proteins and inhibit calmodulin-dependent cyclic nucleotide phosphodiesterase and Ca2+-activated actomyosin. ATPase. Neuroleptics of the butyrophenone group as well as imipramine and diphenehydramine having a low efficiency interact only with calmodulin. Methophenazine, a phenothiazine neuroleptic, being an effective inhibitor of calmodulin and of calmodulin-dependent phosphodiesterase, does not influence troponin C or Ca-dependent actomyosin ATPase. Therefore, this compound may be used as a convenient tool in the study of processes controlled by these Ca-binding proteins. It is concluded that troponin C possesses Ca-dependent sites which bind pharmacological agents structurally similar to that of calmodulin. However, these sites bind pharmacological agents with a low efficiency and exhibit selectivity towards certain drugs. Despite the obvious homology of the both Ca-binding proteins, i.e., calmodulin, troponin C, their effects on the processes under their control appear to be selective.
Baldenkov
G N
GN
Men'shikov
M Iu
MIu
Feoktistov
I A
IA
Tkachuk
V A
VA
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000818:Animals; D014150:Antipsychotic Agents / Q000378:metabolism / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology; D002147:Calmodulin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1; D005456:Fluorescent Dyes; D066298:In Vitro Techniques; D010640:Phenothiazines / Q000378:metabolism / Q000494:pharmacology; D011817:Rabbits; D014336:Troponin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D019209:Troponin C
D014150:Antipsychotic Agents; D002147:Calmodulin; D005456:Fluorescent Dyes; D010640:Phenothiazines; D014336:Troponin; D019209:Troponin C; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1
Vliianie neĭrotropnykh soedineniĭ na kal'modulin- i troponin C-zavisimye protsessy.