Force-displacement measurements in tableting.
The influence of particle interaction, i.e. friction and bonding, on the net work (NETW) during compaction and on Heckel plots was tested by varying the particle size, the lubrication or the moisture content. The NETW was found to be significantly affected by particle interaction. The yield pressure, calculated from Heckel plots, was far less dependent on particle interaction and appears to be more useful for the evaluation of the deformation properties of materials. The NETW may be useful as a test of inter-lot variations in compaction behaviour of materials, due to its high sensitivity to both inter- and intraparticle properties, good reproducibility and low dependence upon die wall conditions. However, it appears to be a poor measure of the plastic properties of the substance.
Ragnarsson
G
G
Sjögren
J
J
D002626:Chemistry, Pharmaceutical; D006244:Hardness; D010316:Particle Size; D013229:Stearic Acids; D013607:Tablets
D013229:Stearic Acids; D013607:Tablets; C031183:stearic acid