[Use of the spin label method for studying the structure of the brain membranes in cats with streptomycin poisoning].
The structural changes in cat brain membranes under the injections of intramuscular streptomycin which is ototoxic antibiotic have been studied. The increase of membrane microviscosity in brain areas which are the direct projection of the auditory way has been revealed using fat acidic spin probe on the basis of stearic acid. The changes in membranes of other brain areas have not been found that exhibits a specific streptomycin influence on the auditory analyzer. The EPR spectra of the hydrocarbon spin label C12H25 localizing in near membrane region don't change in brain membranes of experimental animals compared with the normal ones.
Maksina
A G
AG
Daĭniak
B A
BA
Rakhmanova
I V
IV
D000818:Animals; D001303:Auditory Cortex / Q000032:analysis / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D002415:Cats; D004578:Electron Spin Resonance Spectroscopy; D007425:Intracellular Membranes / Q000032:analysis / Q000187:drug effects; D008563:Membrane Lipids / Q000032:analysis; D008861:Microsomes / Q000032:analysis / Q000187:drug effects; D013113:Spin Labels; D013307:Streptomycin / Q000506:poisoning*; D013997:Time Factors; D014783:Viscosity
D008563:Membrane Lipids; D013113:Spin Labels; D013307:Streptomycin
Primenenie metoda spinovykh zondov dlia izucheniia struktury membran mozga koshek pri streptomitsinovoĭ intoksikatsii.