Platelet tritiated imipramine binding and MAO activity in Alzheimer's disease patients with agitation and delusions.
Decreased platelet 3H-imipramine binding density and decreased monoamine oxidase (MAO) activity have been considered as biological characteristics of several neuropsychiatric disorders, and may be related to central serotonin defects. Since serotonin system defects occur in Alzheimer's disease (AD), and decreased brain 3H-imipramine binding density, and increased brain and platelet MAO activity are reported also, we studied platelet 3H-imipramine binding density (Bmax) and platelet MAO activity in AD outpatients without antecedent psychiatric disorder. AD subjects with significant symptomatic behavioral disorder, predominantly agitation and delusions, and AD subjects without symptomatic behaviors were compared with controls. Age, sex, mini-mental state examination score, and illness duration did not distinguish the two AD groups. The agitated/delusional group showed significantly lower Bmax values than uncomplicated AD subjects or controls. MAO activity was significantly increased among female AD subjects without symptomatic behaviors compared to those who were agitated or to controls. These results indicate that 3H-imipramine binding and MAO activity may distinguish AD subjects with agitation or delusions from those without symptomatic behaviors, and suggest the existence of a biologically based Alzheimer's behavioral subtype.
Schneider
L S
LS
Research Laboratory Technician, University of Southern California School of Medicine, Los Angeles.
Severson
J A
JA
Chui
H C
HC
Pollock
V E
VE
Sloane
R B
RB
Fredrickson
E R
ER
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000201:enzymology* / Q000523:psychology; D001792:Blood Platelets / Q000201:enzymology*; D002352:Carrier Proteins; D003702:Delusions / Q000201:enzymology* / Q000523:psychology; D005260:Female; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics*; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood*; D011595:Psychomotor Agitation / Q000201:enzymology* / Q000523:psychology; D011869:Radioligand Assay; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D008995:Monoamine Oxidase; D007099:Imipramine