Effect of discrete brain lesions on hypothalamic and pituitary immunoreactive dynorphin.
Radiofrequency lesions of the anterior hypothalamic area reduced immunoreactive dynorphin (ir-DYN) in the hypothalamus and in the neurointermediate lobe of the pituitary. Ablation of the medial preoptic area was not associated with any significant modification of ir-DYN in the tissue examined. Destruction of the medial basal hypothalamus in parallel lowered ir-DYN in the hypothalamus and in both pituitary lobes. Neonatal administration of monosodium glutamate had no significant effect on ir-DYN. These findings indicate that changes of ir-DYN in the hypothalamus and pituitary are associated with the destruction of anatomically and functionally distinct neural systems.
Spampinato
S
S
Stanzani
S
S
Ferri
S
S
D000818:Animals; D007025:Anterior Hypothalamic Nucleus / Q000502:physiology; D004399:Dynorphins / Q000032:analysis*; D007031:Hypothalamus / Q000032:analysis*; D007033:Hypothalamus, Middle / Q000502:physiology; D008297:Male; D010904:Pituitary Gland, Posterior / Q000032:analysis*; D011301:Preoptic Area / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D004399:Dynorphins