Improvement of avoidance acquisition by the nootropic drug oxiracetam in mice.
The nootropic drug, oxiracetam (25 or 50 mg/kg i.p.), was tested in two inbred strains of mice, subjected to shuttle-box avoidance training. The drug improved avoidance acquisition in good performers BALB/c mice more than in poor performers C57BL/6 mice. In both cases the avoidance facilitating action was evident only if training was preceded by a five-day pretreatment. The nootropic prototype, piracetam (100 mg/kg), facilitated avoidance acquisition in pretreated BALB/c, but not in C57BL/6 mice.
Sansone
M
M
Castellano
C
C
Ammassari-Teule
M
M
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010889:Piracetam / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology*; D013045:Species Specificity
D000697:Central Nervous System Stimulants; D011759:Pyrrolidines; C040619:oxiracetam; D010889:Piracetam