Reserpinization enhances electroconvulsive treatment effects on cortical alpha 1-adrenoceptors.
Repeated electroconvulsion shock (ECS) for 7 days given to mildly reserpinized rats strongly elevated the density of [3H]prazosin-labelled alpha 1-adrenoceptors and depressed the EC50 for norepinephrine-stimulated inositol phosphate accumulation, while the effects of either treatment given alone were small or negligible. Alterations in alpha 1-adrenoceptor activity caused by ECS could possibly be a function of receptor sensitivity during drug treatment.
Pilc
A
A
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Nalepa
I
I
Vetulani
J
J
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D004597:Electroshock; D006868:Hydrolysis; D007295:Inositol Phosphates / Q000378:metabolism; D008297:Male; D010716:Phosphatidylinositols / Q000378:metabolism; D011224:Prazosin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology*
D007295:Inositol Phosphates; D010716:Phosphatidylinositols; D011942:Receptors, Adrenergic, alpha; D012110:Reserpine; D011224:Prazosin