Synthesis and beta-adrenoceptor blocking activity of thiophenic analogues of metoprolol.
The synthesis of the thiophenic analogue of metoprolol (VI) and of its related compound (VII) are described. Except for cardioselectivity at low doses, the thiophenic analogue of metoprolol behaves in a very similar way as this compound in all the aspects considered in a preliminary pharmacological study.
Conde
S
S
Corral
C
C
Lissavetzky
Darias
V
V
Martin
D
D
D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis*; D000779:Anesthetics, Local; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007928:Lethal Dose 50; D008297:Male; D008790:Metoprolol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D011919:Rats, Inbred Strains
D000319:Adrenergic beta-Antagonists; D000779:Anesthetics, Local; D008790:Metoprolol