[Isocimetidine and analogs. 23. H2-antihistaminics].
Isocimetidine (7), an isomer of cimetidine, as well as the analogous 4-pyrimidones 9a,b were prepared and tested for their H2- and H1-antagonistic activity. 9a,b possess similar pA2-values on the guinea-pig atrium, but smaller H2-selectivity than the corresponding cimetidine analogues, while 7 is less active than cimetidine.
Buschauer
A
A
Schunack
W
W
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002927:Cimetidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000138:chemical synthesis*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects
D006635:Histamine H2 Antagonists; C047311:isocimetidine; D002927:Cimetidine; D006632:Histamine
Isocimetidin und Analoge. 23. Mitt.: H2-Antihistaminika.