Maturation of steroidogenic cells: a target for IGF-I.
Using primary culture of steroidogenic cells in vitro, in serum-free chemically defined medium, strong evidence has been provided for actions of IGF-I on the differentiation of immature Leydig cells and on the maintenance of a differentiated function of mature adrenocortical cells. These data point to the steroidogenic cells as a target for IGF-I action. They also add further evidence for a role of IGF-I in the differentiation process. These actions can be of importance in normal physiological situations as well as in abnormal conditions where IGF-I is decreased, such as hypopituitarism and malnutrition.
Chatelain
P
P
INSERM U307, Hôpital Debrousse, Lyons, France.
Penhoat
A
A
Perrard-Sapori
M H
MH
Jaillard
C
C
Naville
D
D
Saez
J
J
D000302:Adrenal Cortex / Q000187:drug effects*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D003345:Corticosterone / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D007985:Leydig Cells / Q000187:drug effects*; D008297:Male; D011284:Pregnenolone / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D011974:Receptors, LH / Q000032:analysis; D017451:Receptors, Somatomedin; D013002:Somatomedins / Q000494:pharmacology*
D007328:Insulin; D011956:Receptors, Cell Surface; D011974:Receptors, LH; D017451:Receptors, Somatomedin; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D011284:Pregnenolone; D000242:Cyclic AMP; D003345:Corticosterone