title: A study of cerebral blood flow and metabolism in epileptic psychosis using positron emission tomography and oxygen.
abstract: Data are presented on four groups using positron tomography and 15 O inhalation. Compared to age-matched volunteer controls, epileptic patients show regions of low blood flow and hypometabolism as found in previous studies. Epileptic psychotic and non-psychotic patients have been compared, and the main differences noted were lower rOER in the psychotic group, especially in frontal, temporal and basal ganglia regions. When a group of psychotic patients receiving neuroleptic drugs was compared to those free of these medications the rOER was higher in the treated sample, and the rCBF fell, significantly in some areas. These data are discussed in the light of other reports of positron tomography in psychosis.
authors.forename: B
authors.initials: B
authors.lastname: Gallhofer
authors.forename: M R
authors.initials: MR
authors.lastname: Trimble
authors.forename: R
authors.initials: R
authors.lastname: Frackowiak
authors.forename: J
authors.initials: J
authors.lastname: Gibbs
authors.forename: T
authors.initials: T
authors.lastname: Jones
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use; D001479:Basal Ganglia / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000187:drug effects; D003866:Depressive Disorder / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects; D004828:Epilepsies, Partial / Q000503:physiopathology*; D006801:Humans; D008032:Limbic System / Q000098:blood supply; D019965:Neurocognitive Disorders / Q000503:physiopathology*; D009778:Occipital Lobe / Q000098:blood supply; D010101:Oxygen Consumption / Q000187:drug effects; D010104:Oxygen Radioisotopes; D012039:Regional Blood Flow / Q000187:drug effects; D012559:Schizophrenia / Q000503:physiopathology; D013702:Temporal Lobe / Q000098:blood supply; D014055:Tomography, Emission-Computed
chemical_list: D014150:Antipsychotic Agents; D010104:Oxygen Radioisotopes