Systemic ethanol: selective enhancement of responses to acetylcholine and somatostatin in hippocampus.
In rat hippocampal pyramidal cells tested in situ by iontophoresis of several neurotransmitters, ethanol significantly enhanced excitatory responses to acetylcholine and inhibitory responses to somatostatin-14 but had no statistically significant effect on excitatory responses to glutamate or inhibitory responses to gamma-aminobutyric acid or, in preliminary tests, to norepinephrine or serotonin. The effects of ethanol on responses to acetylcholine and somatostatin-14 may provide insight into synaptic mechanisms underlying the behavioral consequences of ethanol intoxication.
Mancillas
J R
JR
Siggins
G R
GR
Bloom
F E
FE
D000109:Acetylcholine / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D006054:Goldfish; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology; D013004:Somatostatin / Q000494:pharmacology*; D013570:Synaptic Membranes / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D012701:Serotonin; D000431:Ethanol; D013004:Somatostatin; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine; D009638:Norepinephrine