Effect of cyclosporin A on murine experimental salmonellosis.
Investigations were undertaken to evaluate the effect of cyclosporin A (CyA) on primary infection of mice with Salmonella typhimurium. Further, its effect on delayed-type hypersensitivity (DTH) and antibody response to porin, an outer membrane protein of S. typhimurium, has been characterized under different CyA regimen. When mice were infected i.p. with 5 x 10(4) live medium virulent organisms, the bacterial growth increased by about 2 log10 in CyA treated mice. CyA administered daily for 2 weeks following immunization with porin caused profound suppression of DTH and both IgM and IgG antibody responses. Given a single dose of CyA 24 h before DTH elicitation, the drug had a marked suppressive effect on DTH, but not on the antibody response to porin. Treatment on days 0-5 following immunization had no effect on the manifestation of the DTH response nor on the anti-porin IgM response whereas an enhanced level of IgG was observed in this group.
Muthukkumar
S
S
Department of Immunology, School of Biological Sciences, Madurai Kamaraj University, India.
Muthukkaruppan
V
V
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D003524:Cyclosporins / Q000494:pharmacology*; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008099:Liver / Q000382:microbiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018272:Porins; D012481:Salmonella Infections, Animal / Q000276:immunology*; D013154:Spleen / Q000382:microbiology
D001425:Bacterial Outer Membrane Proteins; D003524:Cyclosporins; D018272:Porins