Ascorbic acid antagonizes the behavioural effects of LSD in cats.
Pretreatment with ascorbic acid (500 mg kg-1 i.p.) antagonized the behavioural effects of lysergic acid diethylamide (LSD) and apomorphine, but not 5-methoxy-N,N-dimethyltryptamine, in cats. The data support the hypothesis that these behavioural effects in cats are due to drug action at both 5-HT and dopamine receptors, and that the action of LSD at dopamine receptors is modulated by ascorbic acid.
Trulson
M E
ME
Crisp
T
T
Henderson
L J
LJ
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002415:Cats; D008238:Lysergic Acid Diethylamide / Q000037:antagonists & inhibitors*; D008732:Methoxydimethyltryptamines / Q000494:pharmacology
D008732:Methoxydimethyltryptamines; D008238:Lysergic Acid Diethylamide; D001058:Apomorphine; D001205:Ascorbic Acid