Behavioral changes following central injection of cysteamine in rats.
When tested 3 days following 4 daily intracerebroventricular injections of 250 micrograms cysteamine, which depletes somatostatin, rats demonstrated a significant increase in locomotor activity that was not observed in animals treated similarly with 350 micrograms cysteamine. A significant deficit in passive avoidance was observed in animals treated with the 350-micrograms dose, but not in animals treated with 250 micrograms cysteamine. These data suggest that altered activity of the somatostatinergic system disrupts specific processes underlying neural integration of complex behaviors.
Bakhit
C
C
Swerdlow
N
N
D000818:Animals; D001921:Brain / Q000187:drug effects*; D003543:Cysteamine / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000502:physiology*; D009435:Synaptic Transmission
D013004:Somatostatin; D003543:Cysteamine