Intracerebroventricular infusion of somatostatin selectively increases paradoxical sleep in rats.
Chronic intracerebroventricular (i.c.v.) infusion of somatostatin (SRIF) elicited a specific increase of the daily duration of paradoxical sleep (PS) in rats. I.c.v. administration of cysteamine, a selective SRIF depletor, brought about a dose-dependent reduction of PS. Slow wave sleep (SWS) remained unaffected in both cases. These results suggest that SRIF may be involved in the regulation of PS.
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D000818:Animals; D001921:Brain / Q000187:drug effects*; D003543:Cysteamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D012895:Sleep, REM / Q000187:drug effects; D013004:Somatostatin / Q000494:pharmacology* / Q000502:physiology
D013004:Somatostatin; D003543:Cysteamine