Influence of serum protein binding on hepatic clearance of S-disopyramide in the rabbit.
The effect of changing the protein binding of S-disopyramide, a compound that is highly extracted by the liver on its hepatic clearance in rabbits is described. Using indocyanine green clearance as a means of measuring hepatic blood flow, qualitative changes were observed which are in agreement with the results predicted by both the 'parallel tube' and the 'well-stirred' models. However, neither model alone could explain the quantitative changes. Suggestions are put forward to explain these results.
Huang
J D
JD
Oie
S
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D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D004206:Disopyramide / Q000097:blood / Q000378:metabolism*; D007208:Indocyanine Green; D008099:Liver / Q000378:metabolism*; D008297:Male; D009961:Orosomucoid / Q000378:metabolism; D011485:Protein Binding; D011817:Rabbits; D013997:Time Factors
D001798:Blood Proteins; D009961:Orosomucoid; D004206:Disopyramide; D007208:Indocyanine Green