title: Transsphenoidal surgery for acromegaly--long-term results in 100 patients.
abstract: A series of 100 patients with acromegaly who were operated on using the transsphenoidal microsurgical approach is presented along with a review of the literature. Emphasis is placed on long-term follow-up to assess the value of the technique. The authors caution against early normalization of growth hormone as a criterion for biologic cure in that cases of late recurrence are presented. It is proposed that 5 ng/mL baseline growth hormone values with normal dynamic testing is the most reliable way to ascertain biologic cure. Using these criteria, a cure rate of 78% for enclosed and 33% for invasive adenomata was obtained. No long-term recurrence was seen in patients considered cured along these lines.
authors.forename: F
authors.initials: F
authors.lastname: Grisoli
authors.forename: T
authors.initials: T
authors.lastname: Leclercq
authors.forename: P
authors.initials: P
authors.lastname: Jaquet
authors.forename: M
authors.initials: M
authors.lastname: Guibout
authors.forename: J P
authors.initials: JP
authors.lastname: Winteler
authors.forename: J
authors.initials: J
authors.lastname: Hassoun
authors.forename: F
authors.initials: F
authors.lastname: Vincentelli
mesh_terms: D000172:Acromegaly / Q000378:metabolism / Q000601:surgery*; D000236:Adenoma / Q000032:analysis / Q000601:surgery*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000032:analysis; D010911:Pituitary Neoplasms / Q000032:analysis / Q000601:surgery*; D013004:Somatostatin / Q000032:analysis; D013997:Time Factors
chemical_list: D013004:Somatostatin