Are prostaglandins involved in somatostatin mediated inhibition of gastric secretion in the cat?
The role of prostaglandins in somatostatin mediated gastric inhibitory effects has been investigated in conscious cats. The effect of somatostatin on pentagastrin-, insulin- and histamine plus bethanechol-stimulated gastric acid and pepsin secretion was determined with and without indomethacin pretreatment. Somatostatin significantly inhibited acid and pepsin secretion and this effect was not diminished by cyclo-oxygenase inhibition. It is concluded that there is no evidence that endogenous prostaglandins mediate the inhibitory effects of somatostatin on gastric acid and pepsin secretion in the cat.
Albinus
M
M
Frisch
G
G
D000818:Animals; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000494:pharmacology; D002415:Cats; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism*; D011453:Prostaglandins / Q000502:physiology*; D013004:Somatostatin / Q000494:pharmacology*
D001626:Bethanechol Compounds; D007328:Insulin; D011453:Prostaglandins; D018723:Bethanechol; D013004:Somatostatin; D006632:Histamine; D010434:Pepsin A; D010418:Pentagastrin; D007213:Indomethacin