[Importance of adrenoreactive vessels in the mechanisms of the vasoconstrictor response to hyperoxia].
Experiments in 116 white rats showed that high--pressure oxygen (3 beta 3.9 kPa--50 min) increased the adrenoreactivity of vessels under stimulation of alpha--adrenoreceptors with mesaton (phenylephrine) and lost this ability after blockade with pyroxan. The vasoconstricting response (the increase of blood pressure and of general peripheral resistance of vessels) seem to stem from interaction of high--pressure oxygen with post--synaptic alpha--adrenoreceptors of vessels.
Leonov
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AN
Filatov
A V
AV
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D004146:Dioxanes / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006470:Hemorrhage / Q000503:physiopathology; D006931:Hyperbaric Oxygenation; D007022:Hypotension / Q000503:physiopathology; D008297:Male; D010100:Oxygen / Q000494:pharmacology*; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects*
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine; D010100:Oxygen; C009143:proroxan
Znachenie adrenoreaktivnosti sosudov v mekhanizmakh vazokonstrik-tornoĭ reaktsii na giperoksiiu.