The effect of adding albumin to solutions of somatostatin (SST-14) on inhibiting pentagastrin-stimulated acid secretion in man.
The aim of this study was to identify the somatostatin (SST-14) dose dissolved in 0.1% human albumin solution equivalent to the commonly used therapeutic dose (3.5 micrograms kg-1 h-1) dissolved in saline in inhibiting pentagastrin-stimulated gastric acid secretion in healthy volunteers. Gastric acid secretion was stimulated for 3.5 h by intravenous pentagastrin (3 micrograms kg-1 h-1). 0.875 or 1.75 micrograms kg-1 h-1 SST-14 dissolved in 0.1% albumin was significantly (p less than 0.05) less effective in inhibiting stimulated gastric acid secretion than the standard therapeutic dose. There was no difference achieved in the degree of inhibition with albumin added or not to the 3.5 micrograms kg-1 h-1 dose of SST-14. However, an intermediate dose (2.625 micrograms kg-1 h-1) of SST-14, whether dissolved in albumin or saline alone, was as effective as the standard therapeutic SST-14 dose. We conclude that at these high does the absorption of a small quantity of SST-14 to glass and plastic surfaces of the infusion sets has no influence on the therapeutic effect.
Whitehouse
I
I
Beglinger
C
C
Bally
H
H
Gyr
K
K
D000328:Adult; D000418:Albumins / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*
D000418:Albumins; D013004:Somatostatin; D010418:Pentagastrin