title: Hydatidiform mole and HLA. II. Compatibility between patient and conceptus.
abstract: In 52 conceptuses with known genomic origin, the HLA types expressed on whole villi and/or stromal cell cultures were compared with the HLA types of the patients. No preference for either HLA compatibility or incompatibility was found for androgenetic and paternally derived triploid conceptuses as a whole. Heterozygous, androgenetic, conceptuses, however, showed a trend towards preferential incompatibility, which may be of importance for their apparent greater risk for trophoblastic tumour. HLA antibodies were found in 19.2% of the women, i.e. in the range reported for molar as well as non-molar pregnancies. Non-HLA antibodies reacting with lymphocytes of the spouse and/or cells from the conceptus were observed.
authors.affiliation: Institute of Forensic Genetics, Copenhagen, Denmark.
authors.forename: H E
authors.initials: HE
authors.lastname: Hansen
authors.forename: L O
authors.initials: LO
authors.lastname: Vejerslev
authors.forename: S O
authors.initials: SO
authors.lastname: Larsen
mesh_terms: D003602:Cytotoxicity, Immunologic; D005260:Female; D005333:Fetus / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics* / Q000276:immunology; D008297:Male; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000453:epidemiology / Q000276:immunology; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000276:immunology
chemical_list: D006680:HLA Antigens