The effect of prostaglandin D2 on angiotensin converting enzyme.
Intravenous administration of prostaglandin D2 (2, 4 and 8 micrograms/kg) in the rat resulted in a dose-dependent decrease in arterial pressure with partial recovery occurring during the course of the experiment. Hematocrit and hemoglobin decreased in all groups, probably related to the blood withdrawal and volume replacement. Increase in serum glucose is not specific to prostaglandin D2 and a progressive increase occurred even in the vehicle controls. Despite the fact that arterial pressure decreased with the injection of this prostanoid, angiotensin-converting enzyme did not change significantly. The results of this study demonstrate no association between the administration of prostaglandin D2 and angiotensin-converting enzyme within the concentrations we have used in these experiments.
Rao
P S
PS
Department of Obstetrics and Gynecology, College of Medicine University of South Florida, Tampa 33612.
Cavanagh
D
D
O'Brien
W F
WF
Spaziani
E
E
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D015230:Prostaglandin D2 / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D007703:Peptidyl-Dipeptidase A; D015230:Prostaglandin D2