Hereditary blood coagulation factor-VII deficiency in the beagle: immunological characterisation of the defect.
In the plasma of beagles known to be homozygotes for hereditary blood coagulation factor-VII deficiency, antibody neutralization assays indicate only slightly greater quantities of factor-VII related antigen than are detected by conventional assays of procoagulant activity. Plasma of one dog was depleted of factor-VII procoagulant activity by exposure to an immobilized antibody; the low level of activity originally present was then verified by titration with normal plasma. The plasma defect results from an incomplete deletion of synthesis.
Spurling
N W
NW
D000818:Animals; D000906:Antibodies; D000936:Antigen-Antibody Complex; D004283:Dog Diseases / Q000097:blood / Q000235:genetics*; D004285:Dogs; D005167:Factor VII / Q000032:analysis; D005168:Factor VII Deficiency / Q000235:genetics / Q000662:veterinary*
D000906:Antibodies; D000936:Antigen-Antibody Complex; D005167:Factor VII