title: Subchromosomal localization and order of GLA, PGK1, HPRT, and G6PD loci on the X chromosome of the American mink (Mustela vison).
abstract: Segregation of the X-linked mink markers alpha-galactosidase (GLA), phosphoglycerate kinase-1 (PGK1), hypoxanthine phosphoribosyltransferase (HPRT), and glucose-6-phosphate dehydrogenase (G6PD) was analyzed in hybrids of gamma-irradiated mink fibroblasts and Chinese hamster cells and in hybrids of nonirradiated mink fibroblasts and mouse hepatoma cells. Based on this analysis, the order of the four genes is GLA-PGK1-HPRT-G6PD on the mink X chromosome. Cytogenetic analysis of five mink x Chinese hamster hybrid clones containing mink GLA, PGK1, and HPRT, but lacking G6PD, tentatively localized mink G6PD to Xq15.22----qter and also confirmed the gene order as GLA-PGK1-HPRT-G6PD-qter. Comparison of this order with its counterpart in man and the mouse, as well as an analysis of the G-band patterns of their X chromosomes, demonstrated putative similarities between mink and man and differences in the mouse. These differences may be due to a different rate of X-chromosomal rearrangement in mammalian evolution.
authors.affiliation: Institute of Cytology and Genetics, Academy of Sciences, USSR, Novosibirsk.
authors.forename: N S
authors.initials: NS
authors.lastname: Zhdanova
authors.forename: S D
authors.initials: SD
authors.lastname: Pack
authors.forename: N A
authors.initials: NA
authors.lastname: Mazurok
authors.forename: T B
authors.initials: TB
authors.lastname: Nesterova
authors.forename: A A
authors.initials: AA
authors.lastname: Gradov
authors.forename: O L
authors.initials: OL
authors.lastname: Serov
mesh_terms: D000818:Animals; D002460:Cell Line; D002871:Chromosome Banding; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D005347:Fibroblasts; D008040:Genetic Linkage; D005819:Genetic Markers; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D008297:Male; D051379:Mice; D008907:Mink / Q000235:genetics*; D010735:Phosphoglycerate Kinase / Q000235:genetics; D014407:Tumor Cells, Cultured; D014960:X Chromosome; D000519:alpha-Galactosidase / Q000235:genetics
chemical_list: D005819:Genetic Markers; D005954:Glucosephosphate Dehydrogenase; D007041:Hypoxanthine Phosphoribosyltransferase; D010735:Phosphoglycerate Kinase; D000519:alpha-Galactosidase