Adrenergic control of lipolysis in adipocytes of several mammalian species.
The effects of alpha- and beta-adrenergic drugs on catecholamine- and theophylline-induced lipolysis were studied in isolated adipocytes of hamsters, mice, guinea-pigs, gerbils and cats. The ability of the beta-blocker propranolol to diminish the lipolytic rate indicates the presence of beta-adrenergic receptors. Lipolysis was also decreased by the alpha-agonists clonidine and phenylephrine, suggesting the existence of alpha-adrenergic receptors.
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D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002415:Cats; D003000:Clonidine / Q000494:pharmacology; D006224:Cricetinae; D004837:Epinephrine / Q000494:pharmacology; D005849:Gerbillinae; D007545:Isoproterenol / Q000494:pharmacology; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008813:Mice, Inbred ICR; D010646:Phentolamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013045:Species Specificity; D013806:Theophylline / Q000494:pharmacology
D010656:Phenylephrine; D011433:Propranolol; D013806:Theophylline; D007545:Isoproterenol; D003000:Clonidine; D004837:Epinephrine; D010646:Phentolamine