Ischemic CA-1 pyramidal cell loss is prevented by preischemic colchicine destruction of dentate gyrus granule cells.
Hippocampal CA-1 pyramidal cell damage was produced by 20 min of cerebral ischemia. Colchicine destruction of the dentate gyrus granule cells 11 days before ischemia prevented the CA-1 cell loss. It is suggested that the protective effect of degranulation on ischemic CA-1 pyramidal cell damage is due to reduction of glutamate release in CA-1 during and after ischemia.
Johansen
F F
FF
Jørgensen
M B
MB
Diemer
N H
NH
D000818:Animals; D003078:Colchicine; D004827:Epilepsy / Q000209:etiology; D005971:Glutamates / Q000502:physiology; D018698:Glutamic Acid; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology*; D002546:Ischemic Attack, Transient / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000502:physiology; D009435:Synaptic Transmission
D005971:Glutamates; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D018698:Glutamic Acid; D003078:Colchicine