title: Verotoxin and neuraminidase induced platelet aggregating activity in plasma: their possible role in the pathogenesis of the haemolytic uraemic syndrome.
abstract: Certain strains of Escherichia coli producing verotoxin have been isolated in the stools of patients with the haemolytic uraemic syndrome. A platelet aggregating activity has been found in normal plasma after incubation with verotoxin at 37 degrees C for 24 h. This activity, unlike neuraminidase, has an effect that is independent of changing factor VIII related antigen, but requires the IIA and IIIB platelet surface glycoprotein (deficient in thrombasthenia) to mediate its effect. Prostacyclin totally inhibited this effect, but other antiplatelet drugs and heparin were without inhibitory effects.
authors.forename: P E
authors.initials: PE
authors.lastname: Rose
authors.forename: J A
authors.initials: JA
authors.lastname: Armour
authors.forename: C E
authors.initials: CE
authors.lastname: Williams
authors.forename: F G
authors.initials: FG
authors.lastname: Hill
mesh_terms: D001427:Bacterial Toxins / Q000494:pharmacology*; D001791:Blood Platelet Disorders / Q000097:blood; D003016:Clostridium perfringens; D004926:Escherichia coli; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology*; D006801:Humans; D009439:Neuraminidase / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D022622:Shiga Toxin 1; D014842:von Willebrand Diseases / Q000097:blood
chemical_list: D001427:Bacterial Toxins; D022622:Shiga Toxin 1; D009439:Neuraminidase