title: Serological evidence of Hantaan virus infection in the United States.
abstract: We found low titers of fluorescent antibodies against Hantaan virus, the etiologic agent of Korean hemorrhagic fever, in sera from 7 of 1,035 patients with febrile illnesses of unknown origin and from 6 of 664 blood donors in the United States. All but 1 of these individuals possessed neutralizing antibodies against Hantaan virus. This was a 31-year-old research technician who had worked with laboratory rodents with virus-induced tumors, but had not traveled abroad, suggesting that infection with Hantaan virus or a closely related agent was locally acquired. However, the precise source of his infection remains unclear.
authors.forename: R
authors.initials: R
authors.lastname: Yanagihara
authors.forename: C T
authors.initials: CT
authors.lastname: Chin
authors.forename: M B
authors.initials: MB
authors.lastname: Weiss
authors.forename: D C
authors.initials: DC
authors.lastname: Gajdusek
authors.forename: A R
authors.initials: AR
authors.lastname: Diwan
authors.forename: J B
authors.initials: JB
authors.lastname: Poland
authors.forename: K T
authors.initials: KT
authors.lastname: Kleeman
authors.forename: C M
authors.initials: CM
authors.lastname: Wilfert
authors.forename: G
authors.initials: G
authors.lastname: Meiklejohn
authors.forename: W P
authors.initials: WP
authors.lastname: Glezen
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D006476:Orthohantavirus / Q000276:immunology*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D012328:RNA Viruses / Q000276:immunology*; D014481:United States
chemical_list: D000914:Antibodies, Viral