Tokishakuyakusan stimulates cyclic adenosine 3',5'-monophosphate accumulation and progestin production by corpora lutea.
The effect of Tokishakuyakusan (TS) on rat corpora lutea was examined in vivo and in vitro. In an in vivo study, TS stimulated cyclic adenosine 3',5'-monophosphate (cyclic AMP) accumulation and steroidogenesis by corpora lutea, induced by PMS and hCG. In an incubation study, TS increased cyclic AMP accumulation and progesterone secretion. These results suggest that TS stimulates the corpora lutea to produce progestins via the mediation of cyclic AMP.
Usuki
S
S
Department of Obstetrics and Gynecology, University of Tsukuba, Ibaraki, Japan.
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects* / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006027:Glycosides / Q000494:pharmacology*; D006908:Hydroxyprogesterones / Q000737:chemistry; D010946:Plants, Medicinal; D011374:Progesterone / Q000096:biosynthesis; D011372:Progestins / Q000096:biosynthesis*; D051381:Rats
D004365:Drugs, Chinese Herbal; D006027:Glycosides; D006908:Hydroxyprogesterones; D011372:Progestins; C413220:toki-shakuyaku-san; D011374:Progesterone; D000242:Cyclic AMP