[Comparison of astemizole and terfenadine in the treatment of chronic urticaria. A randomized double-blind study of 40 patients].
40 patients suffering from chronic urticaria were randomly treated with either Terfenadine or Astemizole. The treatment period was 8 days after a 4 day wash out phase with placebo. The intensity of the symptoms was quantified and daily recorded by the patients. Both antihistamines influenced significantly the intensity of the pruritus and the flares. With the used study design and dosage slight superiority of Astemizole over Terfenadine could be observed. Neither Astemizole nor Terfenadine showed sedation side effects. The average amount of the sedation symptom scores was during the therapy phase on the same level as during the placebo phase.
Paul
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Bödeker
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RH
D016589:Astemizole; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D016593:Terfenadine; D014581:Urticaria / Q000188:drug therapy*
D001559:Benzhydryl Compounds; D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D016593:Terfenadine; D016589:Astemizole
Vergleich von Astemizol und Terfenadin in der Behandlung der chronischen Urticaria. Eine randomisierte Doppelblind-Studie an 40 Patienten.