Influence of ganglioside treatment on acrylamide neuropathy in mice. A morphometric study.
Female CBA/J mice were given oral doses of 40 mg/kg acrylamide 3 times weekly for 7 or 11 weeks in order to induce peripheral neuropathy. Half the animals were concurrently treated with 20 mg/kg, subcutaneously, of a ganglioside mixture (Cronassial). The other half received physiological saline and served as control. At the end of 7 or 11 weeks, the tibial nerves were removed and examined histomorphometrically. Every animal had developed a neuropathy. However, the mice treated with the ganglioside mixture showed on both the examination dates a substantially larger proportion of small sprouting nerve fibres than the control. It was concluded from this that treatment with gangliosides stimulated the regenerative potential of the damaged nerves.
Stotzem
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CD
Department of Toxicology/Experimental Pathology, Dr. Madaus GmbH & Co., Cologne, Fed. Rep. of Germany.
Mengs
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U
Odenthal
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KP
D000178:Acrylamides; D000818:Animals; D005260:Female; D005732:Gangliosides / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D008808:Mice, Inbred CBA; D009416:Nerve Regeneration / Q000187:drug effects*; D010525:Peripheral Nerves / Q000473:pathology / Q000503:physiopathology*; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000473:pathology; D013979:Tibial Nerve / Q000473:pathology / Q000503:physiopathology*
D000178:Acrylamides; D005732:Gangliosides