The influence of second messengers and related substances on the sensitivity of early embryos to cytostatic neurochemicals.
"Prenervous" neurotransmitters interact with second messengers in the regulation of early embryogenesis of sea urchins and the clawed frog Xenopus laevis. Propranolol and atropine inhibit cleavage divisions of X. laevis only after their intracellular administration. The level of the membrane potential (including a zero level) of the embryos studied is not essential for the cleavage divisions. Possible mechanisms of action of the "prenervous" neurotransmitters at the intracellular level and their coupling with second messengers are discussed.
Shmukler YuB
Grigoriev
N G
NG
Buznikov
G A
GA
Turpaev
T M
TM
D000818:Animals; D001757:Blastomeres / Q000187:drug effects; D003994:Bucladesine / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology*; D004625:Embryo, Nonmammalian / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology; D012617:Sea Urchins / Q000196:embryology; D012969:Sodium Fluoride / Q000494:pharmacology; D014982:Xenopus laevis / Q000196:embryology
D003994:Bucladesine; D012969:Sodium Fluoride; D011433:Propranolol; D000242:Cyclic AMP; D002118:Calcium