title: Stimulation of guanylate cyclase by atrial natriuretic factor in isolated human glomeruli.
abstract: A 23 amino acid synthetic peptide fragment of atrial natriuretic factor (ANF) stimulated guanylate cyclase activity in isolated human glomeruli in a concentration- and time-dependent manner. ANF activated particulate guanylate cyclase whereas it had no effect on soluble guanylate cyclase. These results demonstrate that the glomerulus is a target structure for ANF in humans. They also suggest that ANF-induced increase in glomerular filtration rate is due to a direct effect of this peptide on the glomerular cells mediated by activation of glomerular guanylate cyclase.
authors.forename: N
authors.initials: N
authors.lastname: Ardaillou
authors.forename: M P
authors.initials: MP
authors.lastname: Nivez
authors.forename: R
authors.initials: R
authors.lastname: Ardaillou
mesh_terms: D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP / Q000378:metabolism; D004789:Enzyme Activation; D006162:Guanylate Cyclase / Q000378:metabolism*; D006801:Humans; D007678:Kidney Glomerulus / Q000187:drug effects / Q000201:enzymology*; D045283:Natriuretic Agents; D010446:Peptide Fragments / Q000032:analysis; D011506:Proteins / Q000494:pharmacology*; D013997:Time Factors
chemical_list: C472955:NPPA protein, human; D045283:Natriuretic Agents; D010446:Peptide Fragments; D011506:Proteins; D009320:Atrial Natriuretic Factor; D006162:Guanylate Cyclase; D006152:Cyclic GMP