title: Automated synthesis system with computer control for the production of [1-11C]fatty acids.
abstract: To accommodate the increasing need for [1-11C]fatty acids for use in routine medical studies and the large amounts of radioactivity required, a more advanced automated synthesis system for the preparation of [1-11C]fatty acids has been constructed. The synthesis of [1-11C]fatty acids has been completely automated using a new separation unit (isobaric Sepaltor) for the extraction procedure, which had caused some difficulties with automation. The yield of [1-11C]palmitic acid was 20-30 mCi, and that of 3-methyl [1-11C]heptadecanoic acid was 2-7 mCi. The time required for the synthesis was less than 30 min from the start of the 11CO2 trapping. This system has been used for more than 20 preparations of [1-11C]palmitic acid and more than 20 preparations of 3-methyl [1-11C]heptadecanoic acid.
authors.affiliation: Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Ido
authors.forename: R
authors.initials: R
authors.lastname: Iwata
authors.forename: K
authors.initials: K
authors.lastname: Hatano
authors.forename: H
authors.initials: H
authors.lastname: Nakanishi
authors.forename: M
authors.initials: M
authors.lastname: Shinohara
authors.forename: S
authors.initials: S
authors.lastname: Iida
mesh_terms: D002250:Carbon Radioisotopes; D005227:Fatty Acids / Q000138:chemical synthesis; D007553:Isotope Labeling; D008838:Microcomputers
chemical_list: D002250:Carbon Radioisotopes; D005227:Fatty Acids