title: Conferring new specificity upon restriction endonucleases by combining repressor-operator interaction and methylation.
authors.affiliation: McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
authors.forename: M
authors.initials: M
authors.lastname: Koob
authors.forename: E
authors.initials: E
authors.lastname: Grimes
authors.forename: W
authors.initials: W
authors.lastname: Szybalski
mesh_terms: D002874:Chromosome Mapping / Q000379:methods; D004262:DNA Restriction Enzymes / Q000378:metabolism*; D004269:DNA, Bacterial / Q000378:metabolism; D004274:DNA, Recombinant / Q000378:metabolism; D005821:Genetic Techniques; D005822:Genetic Vectors; D008745:Methylation; D009875:Operator Regions, Genetic; D011485:Protein Binding; D012097:Repressor Proteins / Q000378:metabolism*; D013379:Substrate Specificity; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D004269:DNA, Bacterial; D004274:DNA, Recombinant; D012097:Repressor Proteins; D014157:Transcription Factors; D004262:DNA Restriction Enzymes