[Effect of benzodiazepines on the activity of AMP deaminase and adenosine deaminase in rat brain tissue in vivo].
Phenazepam (5 mg/200 g) and seduxen (3 mg/200 g) injected intraperitoneally to 184 rats altered AMP-deaminase and adenosine deaminase brain activity. Seduxen was observed to increase AMP-deaminase and adenosine deaminase activity by 89.1% and 32.4%, respectively an hour after the injection. Phenazepam increased the activity of the enzymes by 35.5% and 38.5%, respectively two hours after the injection. The effect is suggested to be due to de novo benzodiazepine-induced enzyme synthesis.
Korotkina
R N
RN
Papin
A A
AA
Karelin
A A
AA
D000659:AMP Deaminase / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D003975:Diazepam / Q000494:pharmacology; D008297:Male; D009700:Nucleoside Deaminases / Q000378:metabolism*; D009709:Nucleotide Deaminases / Q000378:metabolism*; D051381:Rats
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D009700:Nucleoside Deaminases; D009709:Nucleotide Deaminases; D000243:Adenosine Deaminase; D000659:AMP Deaminase; D003975:Diazepam
Vliianie benzodiazepinov na aktivnost' AMF-dezaminazy i adenozindezaminazy v tkani golovnogo mozga krys in vivo.