title: Quantitative autoradiography of beta-adrenoceptors in the cardiac vagus ganglia of the rat.
abstract: We studied beta-adrenoceptors by quantitative autoradiography in the cardiac vagus ganglia of the rat, after incubation of tissue sections with [125I]iodocyanopindolol. The cardiac vagus ganglia presented a high concentration of a single population of high affinity binding sites (Bmax 109 +/- 10 fmol/mg protein; Kd 64 +/- 5 pM). Displacement studies with the beta 1-selective adrenoceptor antagonist CGP 20712 A and the beta 2-selective adrenoceptor antagonist ICI 118,551 indicated that most (80 to 90%) of the binding sites are of the beta 2-type.
authors.affiliation: Unit of Preclinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892.
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: W Z
authors.initials: WZ
authors.lastname: Potter
authors.forename: J M
authors.initials: JM
authors.lastname: Saavedra
mesh_terms: D000818:Animals; D001345:Autoradiography; D005726:Ganglia, Parasympathetic / Q000378:metabolism*; D006321:Heart / Q000294:innervation*; D066298:In Vitro Techniques; D020120:Iodocyanopindolol; D008297:Male; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
chemical_list: D011943:Receptors, Adrenergic, beta; D020120:Iodocyanopindolol; D010869:Pindolol