Stimulation of lung lysyl oxidase activity in hamsters with elastase-induced emphysema.
Lysyl oxidase activity was measured in lung extracts of hamsters with elastase-induced emphysema 8 days after administration of the enzyme and again after 2, 3, and 4 wk. Levels of activity rose rapidly to 7 times the base values determined in the lungs of saline-injected control animals. In parallel with the increase in lysyl oxidase activity, the rate of 14C-lysine incorporation into desmosine and isodesmosine was at its maximum 1 wk after elastase administration, reflecting the lysyl-oxidase-mediated cross-link formation, which is the final step in the resynthesis of the pulmonary elastin destroyed by the elastolytic insult.
Osman
M
M
Kaldany
R R
RR
Cantor
J O
JO
Turino
G M
GM
Mandl
I
I
D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000629:Aminopropionitrile / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D006224:Cricetinae; D003895:Desmosine / Q000378:metabolism; D004646:Emphysema / Q000139:chemically induced / Q000201:enzymology*; D005260:Female; D007524:Isodesmosine / Q000378:metabolism; D008168:Lung / Q000201:enzymology; D008239:Lysine / Q000378:metabolism; D008647:Mesocricetus; D010196:Pancreatic Elastase; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism*
D003895:Desmosine; C027243:beta-aminopropionitrile fumarate; D000629:Aminopropionitrile; D007524:Isodesmosine; D000594:Amino Acid Oxidoreductases; D008249:Protein-Lysine 6-Oxidase; D010196:Pancreatic Elastase; D008239:Lysine