title: Induction of a transient reaginic antibody to tartrazine in an animal model.
abstract: The capacity of tartrazine to initiate reaginic antibody production was investigated in inbred rats. Parenteral administration of tartrazine, when covalently linked to a protein carrier and presented in association with carrageenan, resulted in the production of a transient tartrazine-specific reaginic antibody. This response could be enhanced by a secondary challenge, but declined rapidly and thereafter could not be re-elicited.
authors.forename: S
authors.initials: S
authors.lastname: Nicklin
authors.forename: K
authors.initials: K
authors.lastname: Miller
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000917:Antibody Formation; D001391:Azo Compounds / Q000276:immunology*; D001886:Bordetella pertussis / Q000276:immunology; D002351:Carrageenan / Q000276:immunology; D002352:Carrier Proteins; D004195:Disease Models, Animal / Q000276:immunology; D005856:Germ-Free Life; D007117:Immunization, Secondary; D008297:Male; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats; D011935:Reagins / Q000276:immunology*; D012710:Serum Albumin, Bovine / Q000276:immunology; D013645:Tartrazine / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D000906:Antibodies; D001391:Azo Compounds; D002352:Carrier Proteins; D011935:Reagins; D012710:Serum Albumin, Bovine; D002351:Carrageenan; D013645:Tartrazine