Prolonged remission of Epstein-Barr virus associated lymphoma secondary to T cell-depleted bone marrow transplantation.
High grade non-Hodgkin's lymphoma developed 42 days after allogeneic T cell-depleted bone marrow transplantation (BMT) for idiopathic aplastic anaemia. DNA hybridization studies confirmed clonality and incorporation of Epstein-Barr virus (EBV) genome. Prolonged remission followed low dose chemotherapy, local radiotherapy and early withdrawal of cyclosporin.
Lyttelton
M P
MP
Department of Haematology, Royal Free Hospital, London, UK.
Browett
P J
PJ
Brenner
M K
MK
Norton
J D
JD
Kolman
J L
JL
McGee
J O
JO
Hamilton-Dutoit
S
S
Hoffbrand
A V
AV
Prentice
H G
HG
D000328:Adult; D000741:Anemia, Aplastic / Q000601:surgery; D016026:Bone Marrow Transplantation; D015342:DNA Probes; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D008212:Lymphocyte Depletion; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology* / Q000628:therapy; D008297:Male; D012074:Remission Induction; D015183:Restriction Mapping; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous; D014412:Tumor Virus Infections / Q000209:etiology* / Q000628:therapy
D015342:DNA Probes