Lack of linkage of familial Wilms' tumour to chromosomal band 11p13.
Wilms' tumour (WT), a paediatric renal neoplasm, affect approximately 1 in 10,000 children. One or both kidneys can be affected and 5-10% of tumours are bilateral. Most tumours occur sporadically; however, around 1% of the cases are familial, with siblings or cousins most often being affected. Familial cases are more frequently bilateral, and familial and bilateral tumours are diagnosed at an earlier age. On the basis of these observations, it was proposed that the development of WT requires two mutations. In most sporadic unilateral WT, both are somatic; in familial and bilateral tumours the first is thought to be germinal. Cytogenetic and molecular studies have demonstrated germinal mutations in WT/aniridia patients and somatic mutations in sporadic WT at chromosomal band 11p13. To investigate whether familial predisposition to WT is due to a germinal 11p13 mutation, we studied a WT family with seen DNA markers that span the 11p13 region. We found that familial WT predisposition was not genetically linked to any of the 11p13 markers. This suggests that the gene involved in familial WT predisposition is outside 11p13 and is distinct from the gene involved in tumorigensis and in WT predisposition in WT/aniridia 11p13-deletion patients.
Huff
V
V
Department o Biochemistry and Molecular Biology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Compton
D A
DA
Chao
L Y
LY
Strong
L C
LC
Geiser
C F
CF
Saunders
G F
GF
D002880:Chromosomes, Human, Pair 11; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D010375:Pedigree; D009396:Wilms Tumor / Q000235:genetics*
D005819:Genetic Markers