Experimental activation of latent cytomegalovirus infection of the captive bred (F1) cynomolgus monkeys by live or killed varicella-zoster virus inoculated under immunosuppression.
F1 cynomolgus monkeys bred in captivity and thought to be "SPF" had latent cytomegalovirus (CMV) infection although less frequently than in wild-born monkeys. Latent CMV could be activated under severe immunosuppression by inoculation with a certain strain of varicella-zoster virus (VZV) as shown in a previous study. We carried out further experiments using live and formalin-inactivated VZV in F1 monkeys which were sero-positive for CMV, but not for any other viruses. The results showed that both live and inactivated VZV were equivalent in permitting activation of latent CMV, suggesting that the VZV inoculum merely played an immunogenic, but not any virological, role in this case. Captive F1 monkeys, however, carried fewer CMV, and/or resisted CMV reactivation more than the wild monkeys in the previous studies, judging from the time required for generalized CMV infection to become expressed.
Ohtaki
S
S
Department of Pathology, National Institute of Health of Japan, Tokyo.
Hondo
R
R
Kodama
H
H
Kurata
T
T
D000818:Animals; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005455:Fluorescent Antibody Technique; D014645:Herpesvirus 3, Human / Q000276:immunology* / Q000472:pathogenicity; D007165:Immunosuppression Therapy; D007274:Injections, Intraperitoneal; D008252:Macaca fascicularis; D008297:Male; D012699:Serology