title: Kinetics of monosodium glutamate in human volunteers under different experimental conditions.
abstract: The kinetics of glutamic acid (GA) in plasma was studied in human volunteers after administration of monosodium glutamate (MSG) at different doses--43 mg/kg (3 g/70 kg) and 64 mg/kg (4.5 g/70 kg)--and in bouillon solutions of different concentrations (1.5-3.5%). MSG was administered to the subjects either during fasting or immediately after a standard meal. In the fasted subjects MSG administration caused a dose-dependent increase in plasma GA levels. In contrast, ingestion of MSG with a meal did not result in any significant increases in plasma GA levels in comparison with the wide variations observed in plasma GA after ingestion of a meal without added MSG.
authors.forename: P
authors.initials: P
authors.lastname: Ghezzi
authors.forename: M
authors.initials: M
authors.lastname: Bianchi
authors.forename: L
authors.initials: L
authors.lastname: Gianera
authors.forename: M
authors.initials: M
authors.lastname: Salmona
authors.forename: S
authors.initials: S
authors.lastname: Garattini
mesh_terms: D000328:Adult; D004435:Eating; D005215:Fasting; D005971:Glutamates / Q000097:blood / Q000378:metabolism*; D018698:Glutamic Acid; D006801:Humans; D007700:Kinetics; D008297:Male; D012970:Sodium Glutamate / Q000378:metabolism*
chemical_list: D005971:Glutamates; D018698:Glutamic Acid; D012970:Sodium Glutamate