PCP, THC, ethanol, and morphine and consumption of palatable solutions.
Water-deprived rats were given daily opportunities (2.0-hr sessions) to take water or a sweet solution (20% or 24% sugar-water). After stable intakes of each fluid were achieved, the effects of phencyclidine hydrochloride (PCP), delta-9-tetrahydrocannabinol (THC), ethanol (E), and morphine (M) on intakes were tested. PCP, THC, and M all enhanced intake of the sweet solution, while E produced varying effects across doses tested. With other rats, nearly the same procedure was used except that the test solution presented with water was 0.9% sodium chloride. Doses of PCP enhanced intake of the salty solution. These data, combined with the data from similar studies of the effects of opioids and benzodiazepines, indicate that a wide variety of agents that are self-administered also modify intake of ingesta.
Milano
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WC
Department of Psychology, Rensselaer Polytechnic Institute, Troy, NY 12180.
Wild
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Hui
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Hubbell
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CL
Reid
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LD
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects*; D013759:Dronabinol / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste; D013997:Time Factors
D000431:Ethanol; D009020:Morphine; D013759:Dronabinol; D010622:Phencyclidine