title: Human amoebiasis: the interaction of lymphocyte surface-bound immune complexes and PMNs impairs T cell proliferative responses to E. histolytica mitogen.
abstract: In some of the sera from patients with amoebiasis circulating immune complexes are present which are thought to interact with lymphoid cells, enabling them to elicit a burst of oxygen consumption in PMNs. The intensity of chemiluminescence is related to the presence of C3+ and Fc IgG+ cells in the lymphoid cell suspensions employed. The generation and release of highly reactive oxygen derivatives from PMNs impair T lymphocyte proliferative responses to the E. histolytica mitogen. The Authors suggest that one of the mechanisms by which circulating immune complexes present in the sera of patients with amoebiasis may interfere with T cell-mediated immune responses, is through their binding to the surface of the C3+, Fc IgG+ cells with subsequent stimulation of the PMN oxidative metabolism.
authors.forename: C
authors.initials: C
authors.lastname: De Simone
authors.forename: S
authors.initials: S
authors.lastname: Delia
authors.forename: L
authors.initials: L
authors.lastname: Di Meco
authors.forename: C
authors.initials: C
authors.lastname: Mastroianni
authors.forename: C
authors.initials: C
authors.lastname: Mastropietro
authors.forename: V
authors.initials: V
authors.lastname: Vullo
authors.forename: F
authors.initials: F
authors.lastname: Sorice
mesh_terms: D000328:Adult; D000562:Amebiasis / Q000276:immunology*; D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology*; D000953:Antigens, Protozoan / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D004748:Entamoeba histolytica / Q000276:immunology*; D004749:Entamoebiasis / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D008213:Lymphocyte Activation; D008934:Mitogens / Q000494:pharmacology; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism; D010101:Oxygen Consumption; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex; D000953:Antigens, Protozoan; D008934:Mitogens