Purine nucleoside and nucleotide regulation of high affinity [3H]glutamate and [3H]aspartate uptake into rat brain synaptosomes.
Purine nucleotides may interact with neurotransmitter transport sites either via specific receptor sites or as donors of high energy phosphate groups. This study shows that purine nucleotides and nucleosides have no effect on the high affinity transport of aspartate. However, the inhibition of high affinity glutamate transport by ATP and GTP may be mediated through a mechanism involving membrane protein phosphorylation.
Arbuthnot
P B
PB
Cantrill
R C
RC
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D007700:Kinetics; D011684:Purine Nucleosides / Q000494:pharmacology*; D011685:Purine Nucleotides / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D013574:Synaptosomes / Q000378:metabolism*
D005971:Glutamates; D011684:Purine Nucleosides; D011685:Purine Nucleotides; D001224:Aspartic Acid; D018698:Glutamic Acid