[Role of cyclic AMP in the action of dopamine on the spontaneous and glutamate-induced activity of neostriatal neurons in the rat].
The influence of microionophoretically applied dopamine and dibutyril cAMP on the background and glutamate-evoked spike activity of neostriatum neurons was studied in acute experiments on rats immobilized by d-tubocurarine. The mean rate, stationarity, interspike interval histograms and autocorrelation functions for extracellularly recorded spike activity were measured. It was shown that dibutyril cAMP imitated the inhibiting dopamine effect on the background and glutamate-evoked spike activity of neostriatum neurons rather than the stimulating effect.
Godukhin
O V
OV
Kuz'minykh
S B
SB
Budantsev
A Iu
AIu
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects*; D000242:Cyclic AMP / Q000502:physiology*; D004298:Dopamine / Q000494:pharmacology*; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D007478:Iontophoresis; D008297:Male; D008845:Microinjections; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains
D005971:Glutamates; D009419:Nerve Tissue Proteins; D018698:Glutamic Acid; D003994:Bucladesine; D000242:Cyclic AMP; D004298:Dopamine
Rol' tsAMF v deĭstvii dofamina na fonovuiu i vyzvannuiu glutamatom aktivnost' neĭronov neostriatuma krysy.