[The density of lymphocyte beta 2-adrenoreceptors and blood plasma catecholamines in patients with dilated cardiomyopathy].
27 patients with dilated cardiomyopathy (DCM) complicated by heart failure (HF) of stages I-IIB were studied. The density of lymphocyte beta 2-adrenoceptors decreased significantly as HF progressed. The level of circulating catecholamines (epinephrine, norepinephrine) was significantly higher in patients were severe HF, which probably caused more evident decrease in lymphocyte beta 2-adrenoceptors density in these patients. This point of view was confirmed by the data of correlation-regression analysis between the general beta 2-adrenoceptors density and hemodynamics data. The identified changes in the number of adrenoceptors reflect the process of cellular receptors desensitization. They should be considered as a possible mechanism of HF development on a molecular level that cause development of refractoriness to routine therapy.
Gabrusenko
S A
SA
Naumov
V G
VG
Krasnikova
T L
TL
Korichneva
I L
IL
Masenko
V P
VP
D000293:Adolescent; D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000097:blood* / Q000150:complications; D004837:Epinephrine / Q000097:blood*; D006333:Heart Failure / Q000097:blood / Q000209:etiology; D006801:Humans; D008214:Lymphocytes / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D011863:Radioimmunoassay; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000032:analysis*
D011943:Receptors, Adrenergic, beta; D009638:Norepinephrine; D004837:Epinephrine
Plotnost' beta 2-adrenoretseptorov limfotsitov i katekholaminy plazmy krovi u bol'nykh dilatatsionnoĭ kardiomiopatieĭ.