[Directed synthesis of 2',5'-oligoadenylates with increased stability towards phosphodiesterases].
Phosphodiesterase stability of synthetic analogs of 2',5'-oligoadenylates, the mediators of antiviral and antiproliferative action of interferons was analysed. The analogs with a 3'-terminal acyclic nucleoside residue were prepared. These analogs were treated with NIH3T3 cell lysate, mice liver homogenate and snake venom phosphodiesterase. All analogs have demonstrated a high stability as compared with the natural 2',5'-oligoadenylate and its 3'-deoxyderivative. The possible biological activity of these stable analogs of 2',5'-oligoadenylates is discussed.
Itkes
A V
AV
Karpeĭskiĭ
M Ia
MIa
Kartasheva
O N
ON
Mikhaĭlov
S N
SN
Moiseev
G P
GP
D000227:Adenine Nucleotides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D051379:Mice; D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*
D000227:Adenine Nucleotides; D009843:Oligoribonucleotides; C023505:2',5'-oligoadenylate; D010727:Phosphoric Diester Hydrolases
Napravlennoe sozdanie 2',5'-oligoadenilatov s povyshennoĭ ustoĭchivost'iu k fosfodiésterazam.