Benzodiazepine antagonist Ro 15-1788 in self-poisoning. Diagnostic and therapeutic use.
Thirteen patients with benzodiazepine overdosage received the specific benzodiazepine antagonist Ro 15-1788. Intravenous administration of 1.5 to 10 mg reversed the central nervous system depression induced by different benzodiazepine compounds within one to two minutes of injection. These case reports indicate that Ro 15-1788 may be an effective tool in the primary management of self-poisoning.
Hofer
P
P
Scollo-Lavizzari
G
G
D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000037:antagonists & inhibitors / Q000506:poisoning*; D000931:Antidotes; D001570:Benzodiazepinones / Q000627:therapeutic use*; D003128:Coma / Q000139:chemically induced / Q000188:drug therapy; D003975:Diazepam / Q000506:poisoning; D004569:Electroencephalography; D005260:Female; D005442:Flumazenil; D005445:Flunitrazepam / Q000506:poisoning; D006801:Humans; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000627:therapeutic use; D013406:Suicide, Attempted
D014151:Anti-Anxiety Agents; D000931:Antidotes; D001570:Benzodiazepinones; D009270:Naloxone; D005442:Flumazenil; D005445:Flunitrazepam; D003975:Diazepam