title: Inhibition by neosurugatoxin of nicotine-induced antinociception.
abstract: We have found a selective inhibition of nicotine-induced antinociception in mice by neosurugatoxin (NSTX, 0.4-3.8 nmol/kg), a neurotoxin with a high affinity for ganglionic nicotinic receptors (ED50 = 0.65 nmol/kg). The toxin also reduced specific [3H]nicotine binding in mouse brain membranes (IC50 = 95 nM). The anti-nicotinic activity of NSTX was markedly greater than that of mecamylamine and pempidine. These data indicate that NSTX may block functional nicotinic cholinoceptors possibly in the central nervous system.
authors.forename: S
authors.initials: S
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Kagawa
authors.forename: N
authors.initials: N
authors.lastname: Takayanagi
authors.forename: E
authors.initials: E
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Tsuji
authors.forename: T
authors.initials: T
authors.lastname: Kosuge
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D051379:Mice; D008978:Mollusk Venoms / Q000494:pharmacology*; D009538:Nicotine / Q000037:antagonists & inhibitors*; D010146:Pain / Q000188:drug therapy*; D010393:Pempidine / Q000494:pharmacology; D011978:Receptors, Nicotinic / Q000187:drug effects*
chemical_list: D006584:Hexamethonium Compounds; D008978:Mollusk Venoms; D011978:Receptors, Nicotinic; D018738:Hexamethonium; D008464:Mecamylamine; D009538:Nicotine; C036793:neosurugatoxin; D010393:Pempidine