Induced type-B reticulum cell neoplasia of CBA mice. I. Phenotypic similarities between tumorigenic reticulum cells and normal accessory cells.
The phenotype and tumorigenicity of various cell types which occur in induced, transplantable type-B reticulum cell neoplasms of CBA strain mice have been examined. Evidence is presented that the neoplasms contain tumorigenic cells, morphologically defined as reticulum cells, having several phenotypic characteristics of the lymphoid dendritic and veiled accessory cells of normality, and macrophages and small lymphoid cells which are probably reactive cells of host origin.
Brittle
M P
MP
Jacob
M C
MC
Gomer
K
K
Robertson
D
D
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D002469:Cell Separation; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000201:enzymology / Q000276:immunology* / Q000648:ultrastructure; D010587:Phagocytosis; D010641:Phenotype; D011961:Receptors, Fc / Q000032:analysis; D012156:Reticulocytes / Q000276:immunology; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D011961:Receptors, Fc; D018800:Thy-1 Antigens; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase