title: Colostral transfer of Clostridium perfringens type C beta antitoxin in swine.
abstract: Nine bred gilts were vaccinated with 2 doses of a Clostridium perfringens type C toxoid at a 5-week interval. Time of vaccination during gestation differed among the gilts. Clostridium perfringens beta antitoxin in colostral samples and in serum samples was titrated in mice. Blood was collected from 2 to 5 neonatal pigs from each dam (total = 32 pigs) when the pigs were 36 to 48 hours old. Antitoxin titers in colostrum were 123 to 4.5 IU/ml, indicating considerable variation in individual responses of the gilts to toxoid. Serum titers of neonatal pigs reflected colostrum titers of their dams. This colostrum-to-serum titer correlation was essentially a straight-line fit by least-squares linear regression analysis, establishing a direct proportional relationship between colostrum titers and serum titers of neonatal pigs. In the dams, a correlation was not found between colostral titers and serum titers of blood samples collected 2 weeks after collection of colostrum.
authors.forename: P H
authors.initials: PH
authors.lastname: Matisheck
authors.forename: M
authors.initials: M
authors.lastname: McGinley
mesh_terms: D000818:Animals; D000992:Antitoxins / Q000276:immunology*; D003015:Clostridium Infections / Q000517:prevention & control / Q000662:veterinary; D003016:Clostridium perfringens / Q000276:immunology*; D003126:Colostrum / Q000276:immunology* / Q000382:microbiology; D005260:Female; D007112:Immunity, Maternally-Acquired; D011247:Pregnancy; D013552:Swine / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary
chemical_list: D000992:Antitoxins