Characterization of enhanced intestinal permeability; electrophysiological study on the effects of diclofenac and ethylenediaminetetraacetic acid.
The mechanism of the enhancing effects of diclofenac sodium and disodium ethylenediaminetetraacetate (EDTA) on intestinal permeability to sulphanilic acid were investigated in the rat isolated jejunum by an electrophysiological technique. The results suggested that diclofenac sodium increased the mucosal-to-serosal flux rate of sulphanilic acid by enhancing both transcellular and paracellular permeabilities while the effect of EDTA was located only in the paracellular pathway.
Yamashita
S
S
Saitoh
H
H
Nakanishi
K
K
Masada
M
M
Nadai
T
T
Kimura
T
T
D000818:Animals; D004008:Diclofenac / Q000494:pharmacology*; D004492:Edetic Acid / Q000494:pharmacology*; D004594:Electrophysiology; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000378:metabolism; D010539:Permeability; D010648:Phenylacetates / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical
D010648:Phenylacetates; D004008:Diclofenac; D004492:Edetic Acid