Positron emission tomography in schizophrenic patients with and without neuroleptic medication.
Positron emission tomography using [18F]2-fluoro-2-deoxy-D-glucose was performed in nine chronic schizophrenic patients both when medication-free and when medicated with neuroleptics. Total brain cortex, temporal cortex, and basal ganglia glucose use was significantly increased with medication; however, there was no change in anterior/posterior metabolic gradients.
DeLisi
L E
LE
Holcomb
H H
HH
Cohen
R M
RM
Pickar
D
D
Carpenter
W
W
Morihisa
J M
JM
King
A C
AC
Kessler
R
R
Buchsbaum
M S
MS
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002421:Caudate Nucleus / Q000378:metabolism; D002908:Chronic Disease; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy / Q000378:metabolism*; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism; D014055:Tomography, Emission-Computed
D014150:Antipsychotic Agents; D005947:Glucose