Automated synthesis system with computer control for the production of [1-11C]fatty acids.
To accommodate the increasing need for [1-11C]fatty acids for use in routine medical studies and the large amounts of radioactivity required, a more advanced automated synthesis system for the preparation of [1-11C]fatty acids has been constructed. The synthesis of [1-11C]fatty acids has been completely automated using a new separation unit (isobaric Sepaltor) for the extraction procedure, which had caused some difficulties with automation. The yield of [1-11C]palmitic acid was 20-30 mCi, and that of 3-methyl [1-11C]heptadecanoic acid was 2-7 mCi. The time required for the synthesis was less than 30 min from the start of the 11CO2 trapping. This system has been used for more than 20 preparations of [1-11C]palmitic acid and more than 20 preparations of 3-methyl [1-11C]heptadecanoic acid.
Takahashi
T
T
Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Ido
T
T
Iwata
R
R
Hatano
K
K
Nakanishi
H
H
Shinohara
M
M
Iida
S
S
D002250:Carbon Radioisotopes; D005227:Fatty Acids / Q000138:chemical synthesis; D007553:Isotope Labeling; D008838:Microcomputers
D002250:Carbon Radioisotopes; D005227:Fatty Acids