title: Changes in lateral hypothalamic neuronal activity accompanying hyper- and hypoglycemias.
abstract: Blood glucose level and forebrain unit activity were simultaneously recorded in rats anesthetized with a ketamine IV infusion. Slight and transient fluctuations in glycemia, occurring either spontaneously or after IV injections of glucose or phlorizin, were observed. The spike frequency of more than 1/3 of the neurons tested in the lateral hypothalamic area was affected by these fluctuations. A majority of the responsive cells displayed either an activation during hypoglycemia or a depression during hyperglycemia. These neurons might mediate the effects of a drop in blood glucose on either meal initiation or neuroendocrine or autonomic events related to nutritional functions.
authors.affiliation: Laboratoire de Neurobiologie, C.N.R.S., Marseille, France.
authors.forename: T
authors.initials: T
authors.lastname: Himmi
authors.forename: A
authors.initials: A
authors.lastname: Boyer
authors.forename: J C
authors.initials: JC
authors.lastname: Orsini
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001931:Brain Mapping; D007026:Hypothalamic Area, Lateral / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000502:physiology
chemical_list: D001786:Blood Glucose; D011956:Receptors, Cell Surface; C027786:glucose receptor