title: Bone-marrow transplantation for metachromatic leucodystrophy.
abstract: An 11-month-old boy with late infantile metachromatic leucodystrophy was given a bone-marrow transplant (BMT) from an HLA-identical sister; 6 months later his cerebrospinal fluid leucocytes were exclusively of donor origin. Coupled with the patient's continued developmental progress, as assessed 33 months after the procedure, the findings suggest that BMT may be an effective treatment for some congenital metabolic disorders which affect the central nervous system.
authors.forename: E
authors.initials: E
authors.lastname: Bayever
authors.forename: S
authors.initials: S
authors.lastname: Ladisch
authors.forename: M
authors.initials: M
authors.lastname: Philippart
authors.forename: N
authors.initials: N
authors.lastname: Brill
authors.forename: M
authors.initials: M
authors.lastname: Nuwer
authors.forename: R S
authors.initials: RS
authors.lastname: Sparkes
authors.forename: S A
authors.initials: SA
authors.lastname: Feig
mesh_terms: D000293:Adolescent; D001853:Bone Marrow / Q000648:ultrastructure; D016026:Bone Marrow Transplantation; D002553:Cerebroside-Sulfatase / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007962:Leukocytes / Q000201:enzymology / Q000648:ultrastructure; D007966:Leukodystrophy, Metachromatic / Q000134:cerebrospinal fluid / Q000235:genetics / Q000628:therapy*; D008297:Male; D014019:Tissue Donors
chemical_list: D002553:Cerebroside-Sulfatase