The influence of electroshock on adrenoceptor function in rat brain cerebral cortex: selectivity for the alpha-adrenoceptor site.
The present study was undertaken to examine the effect of electroshock on adrenoceptor-mediated cAMP and inositol phosphate accumulation in rat brain cerebral cortical slices. Under the conditions of these experiments, isoproterenol-induced cAMP accumulation was unaltered by electroshock, although there was a significant reduction in the norepinephrine- and isoproterenol + 6-fluoronorepinephrine-stimulated responses. No change in alpha-adrenoceptor-mediated inositol phosphate accumulation was noted. The results indicate that electroshock selectively modifies an alpha-adrenoceptor system in brain that differs from that associated with inositol phosphate accumulation.
Pilc
A
A
Institute of Pharmacology, Polish Academy of Sciences, Kracow, Poland.
Chalecka-Franaszek
E
E
Nalepa
I
I
Vetulani
J
J
Enna
S J
SJ
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism; D004597:Electroshock; D007295:Inositol Phosphates / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*
D002395:Catecholamines; D007295:Inositol Phosphates; D011942:Receptors, Adrenergic, alpha; D000242:Cyclic AMP