A five-coordinate copper complex with superoxide dismutase mimetic activity from Streptomyces antibioticus.
A Cu(II) complex of desferrithiocin from Streptomyces antibioticus was prepared and characterized. The first shell atoms, including one nitrogen and four oxygens, were arranged around the copper in a square-planar pyramide. Due to the axially Jahn-Teller-distorted Cu-O distance at 224.7 pm, a distinct Cu2Zn2superoxide dismutase mimetic activity was measured. The Cu-complex survived 600 microM bovine serum albumin and the thermodynamic stability (pK = 17.4) was not very different from that of Cu-EDTA. The electronic absorption properties, circular dichroism and electron paramagnetism were in accordance with those of the type-II copper species.
Schechinger
T
T
Anorganische Biochemie, Physiologisch-chemisches Institut der Universität Tübingen, Federal Republic of Germany.
Hiller
W
W
Maichle
C
C
Strähle
J
J
Weser
U
U
D002942:Circular Dichroism; D003300:Copper; D004095:Dihydropyridines / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D007502:Iron Chelating Agents / Q000378:metabolism*; D008958:Models, Molecular; D013053:Spectrophotometry; D013302:Streptomyces / Q000201:enzymology*; D013303:Streptomyces antibioticus / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000378:metabolism*; D013816:Thermodynamics; D013844:Thiazoles / Q000378:metabolism*; D014961:X-Ray Diffraction
D004095:Dihydropyridines; D007502:Iron Chelating Agents; D013844:Thiazoles; D003300:Copper; D013482:Superoxide Dismutase; C050223:desferrithiocin