[Quantitative patterns of tubocurarine action on the synaptic potentials of frog muscle].
The dependence of amplitude of synaptic potentials (EPP and mEPP) upon the d-tubocurarine concentration was studied in the frog cutaneous pectoral muscle. In the presence of d-tubocurarine up to 5 x 10(-7) M, the amplitude of EPP and mEPP decreased to the extent which strictly followed competitive action of d-tubocurarine. At a higher concentration, the inhibition of synaptic potentials was stronger than would be expected assuming that d-tubocurarine can only act as a competitive antagonist.
Grigor'ev
V M
VM
Danilov
A F
AF
Skliarov
A I
AI
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005071:Evoked Potentials / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008839:Microelectrodes; D009045:Motor Endplate / Q000187:drug effects / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D011896:Rana temporaria; D017981:Receptors, Neurotransmitter / Q000187:drug effects* / Q000502:physiology; D014403:Tubocurarine / Q000494:pharmacology*
D017981:Receptors, Neurotransmitter; D014403:Tubocurarine
Kolichestvennye zakonomernosti deĭstviia tubokurarina na sinapticheskie potentsialy myshtsy liagushki.