NK cells suppress the generation of Lyt-2+ cytolytic T cells by suppressing or eliminating dendritic cells.
Cells highly enriched for natural killer activity suppress the generation of Lyt-2+ cytolytic T cells in one-way mixed lymphocyte cultures. Suppression occurs because natural killer cells suppress or eliminate dendritic cells, which are required for proliferation of both Ly-1+ and Lyt-2+ lymphocytes.
Gilbertson
S M
SM
Shah
P D
PD
Rowley
D A
DA
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D000950:Antigens, Ly / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D005260:Female; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007376:Interleukin-2 / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D018800:Thy-1 Antigens
D000950:Antigens, Ly; D000954:Antigens, Surface; D007376:Interleukin-2; D018800:Thy-1 Antigens