title: Are prostaglandins involved in somatostatin mediated inhibition of gastric secretion in the cat?
abstract: The role of prostaglandins in somatostatin mediated gastric inhibitory effects has been investigated in conscious cats. The effect of somatostatin on pentagastrin-, insulin- and histamine plus bethanechol-stimulated gastric acid and pepsin secretion was determined with and without indomethacin pretreatment. Somatostatin significantly inhibited acid and pepsin secretion and this effect was not diminished by cyclo-oxygenase inhibition. It is concluded that there is no evidence that endogenous prostaglandins mediate the inhibitory effects of somatostatin on gastric acid and pepsin secretion in the cat.
authors.forename: M
authors.initials: M
authors.lastname: Albinus
authors.forename: G
authors.initials: G
authors.lastname: Frisch
mesh_terms: D000818:Animals; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000494:pharmacology; D002415:Cats; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism*; D011453:Prostaglandins / Q000502:physiology*; D013004:Somatostatin / Q000494:pharmacology*
chemical_list: D001626:Bethanechol Compounds; D007328:Insulin; D011453:Prostaglandins; D018723:Bethanechol; D013004:Somatostatin; D006632:Histamine; D010434:Pepsin A; D010418:Pentagastrin; D007213:Indomethacin