Rapid induction of forestomach tumors in partially hepatectomized Wistar rats given butylated hydroxyanisole.
Rats subjected to two-thirds partial hepatectomy (PH) and given the antioxidant butylated hydroxyanisole (BHA) at a dietary concentration of 2% for 3 months developed forestomach lesions. Histologically, these lesions were classified as hyperplasia, dysplasia of the basal cell, papillomas, and carcinomas in situ. In intact rats forestomach carcinomas were seen by other investigators after feeding 2% BHA for 15-20 months. Histochemical studies of tumors revealed a marked increase in the phenotypic expression of the oncofetal enzyme, gamma-glutamyl transpeptidase (GGT) in the tumors of treated rats.
Abraham
R
R
Benitz
K F
KF
Patil
G
G
Lyon
R
R
D000818:Animals; D000840:Anisoles / Q000494:pharmacology*; D002083:Butylated Hydroxyanisole / Q000378:metabolism / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000473:pathology; D006498:Hepatectomy; D008115:Liver Regeneration; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D000840:Anisoles; D002083:Butylated Hydroxyanisole; D005723:gamma-Glutamyltransferase