title: [Effect of adenylate cyclase system activation on Na+/H+-exchange in human platelets].
abstract: In experiments with human platelets it has been shown, that stimulation of adenylate cyclase by carbacycline (CC)--a stable analog of prostacyclin, does not affect the initial pHi decrease caused by thrombin and PAF, but it abolishes the second phase of pHi changes, a pHi increase resulted from Na+/H+ exchange activation. CC also abolishes pHi increase induced by ionophore A23187 and the activator of protein kinase C, phorbol ester (TPA). The results obtained suggest that cAMP exerts inhibitory action on the agonist induced activation of Na+/H+ exchange but does not affect its pHi-sensitivity in the resting cell.
authors.forename: V G
authors.initials: VG
authors.lastname: Pinelis
authors.forename: M L
authors.initials: ML
authors.lastname: Borin
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Kudinov
authors.forename: S S
authors.initials: SS
authors.lastname: Bykov
authors.forename: O
authors.initials: O
authors.lastname: Azizova
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism*; D000001:Calcimycin / Q000494:pharmacology; D002352:Carrier Proteins / Q000097:blood*; D000242:Cyclic AMP / Q000097:blood; D004789:Enzyme Activation; D011464:Epoprostenol / Q000494:pharmacology / Q000031:analogs & derivatives; D006801:Humans; D066298:In Vitro Techniques; D011522:Protons; D012964:Sodium / Q000097:blood*; D017923:Sodium-Hydrogen Exchangers
chemical_list: D002352:Carrier Proteins; D011522:Protons; D017923:Sodium-Hydrogen Exchangers; D000001:Calcimycin; C026678:carboprostacyclin; D012964:Sodium; D011464:Epoprostenol; D000242:Cyclic AMP; D000262:Adenylyl Cyclases
vernacular_title: Vliianie aktivatsii adenilattsiklaznoĭ sistemy na Na+/H+-obmen v trombotsitakh cheloveka.