Inositol lipid breakdown as a step in alpha-adrenergic stimulus-response coupling.
A widespread, and maybe universal, response to stimulation of alpha-adrenoceptors is inositol lipid hydrolysis: the receptor-coupled event is probably hydrolysis of phosphatidylinositol 4,5-bisphosphate. This reaction generates two second messenger molecules. Inositol 1,4,5-trisphosphate may be responsible for the intracellular mobilization of Ca2+ that has long been recognized as a major mediator of the effects of alpha-receptor activation. In addition, the released 1,2-diacylglycerol probably contributes to control of cell function through activation of protein kinase C.
Michell
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D000818:Animals; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004075:Diglycerides / Q000378:metabolism; D006868:Hydrolysis; D007294:Inositol / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D008954:Models, Biological; D018377:Neurotransmitter Agents / Q000378:metabolism; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols / Q000378:metabolism; D011493:Protein Kinase C; D011494:Protein Kinases / Q000378:metabolism; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000378:metabolism
C011439:1,2-diacylglycerol; D004075:Diglycerides; D008563:Membrane Lipids; D018377:Neurotransmitter Agents; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols; D011942:Receptors, Adrenergic, alpha; D007294:Inositol; D011494:Protein Kinases; D011493:Protein Kinase C; D002118:Calcium