Amineptine: its effect on the dopaminergic system of rats.
3-Methoxytyramine formation was enhanced by amineptine (40 mg kg-1 i.p.) in the striatum and limbic area, indicating an increase in the concentration of dopamine in the extraneuronal space. Since dopamine turnover, determined as the rate of L-dopa accumulation, is reduced by the drug at short (10 min) times, the enhanced extraneuronal dopamine concentration seems mainly related to amineptine-induced inhibition of its uptake.
Ponzio
F
F
Achilli
G
G
Garattini
S
S
Perego
C
C
Sacchetti
G
G
Algeri
S
S
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D003342:Corpus Striatum / Q000378:metabolism; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D004298:Dopamine / Q000031:analogs & derivatives / Q000378:metabolism*; D006834:Hydrazines / Q000494:pharmacology; D007980:Levodopa / Q000378:metabolism; D008032:Limbic System / Q000378:metabolism; D008297:Male; D010293:Pargyline / Q000494:pharmacology; D051381:Rats
D000929:Antidepressive Agents, Tricyclic; D003986:Dibenzocycloheptenes; D006834:Hydrazines; C011597:amineptin; D007980:Levodopa; D010293:Pargyline; C004297:3-hydroxybenzylhydrazine; C001746:3-methoxytyramine; D004298:Dopamine