[Refinement of an EEG diurnal vigilance index. Application to drug trials].
Theta/alpha spectral powers ratio was used to quantify physiological decrease of vigilance occurring after 5 min recording eyes closed, at different times of the day, in normal volunteers with 'high alpha'. Maximum decrease of vigilance occurred at about 2 or 4 p.m. Theta/alpha ratio fluctuations were similar on the homologous right and left scalp areas. This ratio is useful in psychopharmacology to quantify the antagonist activity of a CNS stimulant drug on the physiological decrease of vigilance after 5 min as well as the sedative effect of a drug. It allows to follow the kinetics of the drug action at receptor level.
Goldenberg
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D000513:Alpha Rhythm; D001143:Arousal / Q000187:drug effects / Q000502:physiology*; D001559:Benzhydryl Compounds / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004569:Electroencephalography; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D000077408:Modafinil; D011600:Psychopharmacology / Q000379:methods*; D013826:Theta Rhythm; D014229:Triazolam / Q000494:pharmacology
D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D006993:Hypnotics and Sedatives; D014229:Triazolam; D000077408:Modafinil
Mise au point d'un indice EEG de vigilance diurne. Application aux essais pharmacologiques.