title: [Use of the zwitterion detergent Sulfobetain-12 for preparation of virosomes and investigation of their immunogenic and protective properties].
abstract: Virosomes were prepared by using the zwitterion detergent sulfobetaine-12. The virosomes included the surface antigens and virus-specific lipids of influenza virus, strain A/PR/8/34. Immunogenic and protective properties of the surface antigens in the micellar form and as a complex with the virosomes were studied. The surface antigens of this complex, like the intact virus, were found to possess the high immunogenic and protective activity in relation to the following infection with the homologous pathogenic virus.
authors.forename: L A
authors.initials: LA
authors.lastname: Mazhul'
authors.forename: G V
authors.initials: GV
authors.lastname: Smirnova
authors.forename: V D
authors.initials: VD
authors.lastname: Lotte
authors.forename: L S
authors.initials: LS
authors.lastname: Zhigis
authors.forename: P D
authors.initials: PD
authors.lastname: Reshetov
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis; D003902:Detergents; D009980:Influenza A virus / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000517:prevention & control; D000644:Quaternary Ammonium Compounds; D012995:Solubility; D013501:Surface-Active Agents
chemical_list: D000906:Antibodies; D003902:Detergents; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents; C034730:zwittergent 3-12
vernacular_title: Ispol'zovanie tsvitterionnogo detergenta sul'fobetaina-12 dlia polucheniia virosom i izuchenie ikh immunogennykh i protektivnykh svoĭstv.