[The effect of the beta-blocker nadolol on the second messenger, serum cyclic adenosine monophosphate, and on blood pressure and heart rate].
In this investigation it could be shown that the intracellular alterations of cAMP (cyclic adenosine monophosphate) caused by the beta-receptor blocker (2R,3S)-5-(3-tert-butylamino-2-hydroxypropoxy)-1,2,3,4- -tetrahydro-2,3-naphtalenediol (nadolol, Solgol mite) can also be proved in plasma. 15 hypertensive patients were given 60 mg nadolol; before and after certain intervals plasma cAMP, blood pressure, heart rate and pulmonary function were measured. After a single dose of nadolol within 8 h a prompt, significant decrease of the plasma cAMP concentration from 21.3 pmol/ml to 8.1 pmol/ml could be seen. 8 h later the cAMP concentration increased slowly and after 32 h achieved an average value of 13.1 pmol/ml. Heart rate and systolic blood pressure of the patients showed nearly identical behavior for more than 32 h. Both parameters fell significantly, increased slowly after 8 h and were still on a lower level after 32 h. There was no influence on diastolic blood pressure value and pulmonary function. The results confirm--in accordance with other investigators--the long therapeutical effect of the beta-receptor blocker nadolol; besides they prove that the model used here is a suitable biochemical equivalent in comparison to the pharmacological effect of a beta-receptor blocker.
Weth
G
G
Schneider
J
J
Rodatz
H
H
Haubitz
I
I
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D000242:Cyclic AMP / Q000097:blood*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008875:Middle Aged; D009248:Nadolol; D011412:Propanolamines / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D009248:Nadolol; D000242:Cyclic AMP
Einfluss des beta-Blockers Nadolol auf den second messenger zyklisches Adenosinmonophosphat im Serum sowie auf Blutdruck und Herzfrequenz.