title: Resistance of chickens to Rous sarcoma virus challenge following immunization with a recombinant avian leukosis virus.
abstract: An attenuated recombinant avian leukosis virus (ALV) produced by recombinant DNA techniques was examined for its ability to provide resistance to Rous sarcoma virus (RSV) challenge. Specific-pathogen-free chicken embryos (18-day incubation) and hatched chicks inoculated with recombinant ALV produced significantly smaller tumors than sham-inoculated controls upon challenge with RSV 2 weeks postinoculation; inoculation with RAV-1 produced similar results. Specific-pathogen-free hens inoculated with recombinant ALV produced viral-protein-specific antibody that was transmitted to 100% of the progeny, as detected by enzyme-linked immunosorbent assay. Progeny of the inoculated hens produced significantly fewer tumors than sham-inoculated controls upon challenge with RSV at hatch, indicating that maternal antibody may be a factor in resistance to tumor development.
authors.affiliation: Department of Poultry Science, North Carolina State University, Raleigh 27695-7608.
authors.forename: R M
authors.initials: RM
authors.lastname: Shuman
authors.forename: M A
authors.initials: MA
authors.lastname: McBride
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001354:Avian Leukosis Virus / Q000235:genetics / Q000276:immunology*; D001358:Avian Sarcoma Viruses / Q000235:genetics / Q000276:immunology*; D002645:Chickens; D004274:DNA, Recombinant; D005260:Female; D007112:Immunity, Maternally-Acquired; D007114:Immunization / Q000662:veterinary*; D001357:Sarcoma, Avian / Q000276:immunology / Q000517:prevention & control*; D013047:Specific Pathogen-Free Organisms
chemical_list: D000914:Antibodies, Viral; D004274:DNA, Recombinant