title: Origin, evolution and dissemination of antibiotic resistance genes.
abstract: Comparison of resistance genes from different sources support the hypothesis that the antibiotic-producing microorganisms are the source of resistant determinants present in clinical isolates. There is also evidence that Gram-positive cocci (staphylococci and streptococci) can serve as a reservoir of resistance genes for Gram-negative bacteria.
authors.affiliation: Unité des Agents Antibactériens, Centre National de la Recherche Scientifique U.A. 271, Institut Pasteur, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Trieu-Cuot
authors.forename: M
authors.initials: M
authors.lastname: Arthur
authors.forename: P
authors.initials: P
authors.lastname: Courvalin
mesh_terms: D000595:Amino Acid Sequence; D001419:Bacteria / Q000235:genetics*; D005075:Biological Evolution; D004352:Drug Resistance, Microbial / Q000235:genetics*; D005798:Genes, Bacterial; D019868:Kanamycin Kinase; D008780:Methyltransferases / Q000235:genetics; D008969:Molecular Sequence Data; D010770:Phosphotransferases / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D014162:Transfection
chemical_list: D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase; D010770:Phosphotransferases; D019868:Kanamycin Kinase