Capillary gas chromatographic-mass spectrometric determination of buspirone in plasma.
Methods for determining buspirone plus a deuterated analogue and for buspirone alone in plasma samples are described. Analytes are prepared from plasma by liquid extraction into n-butyl chloride and subsequent back-extraction clean-up steps. Instrumental analysis involves selected-ion monitoring gas chromatography-mass spectrometry with fused-silica capillary chromatography. Quantification is in the range 0.05-10 ng/ml with acceptable accuracy and precision.
Gammans
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RE
Kerns
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Bullen
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D014151:Anti-Anxiety Agents / Q000097:blood*; D001682:Biological Availability; D002065:Buspirone; D055598:Chemical Phenomena; D002621:Chemistry; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007700:Kinetics; D011743:Pyrimidines / Q000097:blood*
D014151:Anti-Anxiety Agents; D011743:Pyrimidines; D002065:Buspirone