Adrenocortical suppression associated with topical otic administration of glucocorticoids in dogs.
Commercial otic preparations that contained dexamethasone or triamcinolone acetate were applied twice daily to both ears of 2 groups of dogs (n = 8). Marked adrenocortical suppression, reflected by low serum cortisol concentrations, was observed in all dogs. Results of ACTH response tests were blunted after 7 days of treatment. Twenty-one days after treatment, serum cortisol concentrations still were suppressed in all dogs, compared with pretreatment control concentrations. Fourteen days after cessation of otic treatment, 5 of 8 dogs still had inadequate release of cortisol in response to ACTH.
Moriello
K A
KA
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
Fehrer-Sawyer
S L
SL
Meyer
D J
DJ
Feder
B
B
D000287:Administration, Topical; D000302:Adrenal Cortex / Q000187:drug effects* / Q000502:physiology; D000324:Adrenocorticotropic Hormone; D000818:Animals; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D004285:Dogs / Q000502:physiology*; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D011897:Random Allocation; D014221:Triamcinolone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
D014221:Triamcinolone; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; C030262:triamcinolone diacetate; D006854:Hydrocortisone