[Mechanisms of transformation of the hormonal signal of steroids in the biological response of the target cell].
The receptor cycle of the steroidal hormones since the moment of the hormone penetration into the cell until the hormone-receptor complex destruction was considered. The interaction of the steroid with the cytoplasmic membrane of the target cell is the primary link in the hormonal effect implementation. The steroidal regulation of matrix activity of the genome is mediated by intracellular receptors of the steroids located in the cytoplasm of the target cell. Sites of specific binding of the steroids were found also on the membranes of mitochondria, lysosomes, endoplasmic reticulum. The effect of the steroids on the functioning of these subcellular organelles is extragenomic. The interaction of the steroidal molecule with different receptors triggers the cascade of the biochemical reactions determining the tissue response to the hormonal signal.
Sergeev
P V
PV
Dukhanin
A S
AS
D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006728:Hormones / Q000493:pharmacokinetics*; D006801:Humans; D015388:Organelles / Q000187:drug effects / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism; D011987:Receptors, Steroid / Q000187:drug effects / Q000378:metabolism; D015290:Second Messenger Systems / Q000187:drug effects; D013256:Steroids / Q000493:pharmacokinetics*
D006728:Hormones; D011956:Receptors, Cell Surface; D011987:Receptors, Steroid; D013256:Steroids
Mekhanizmy preobrazovaniia gormonal'nogo signala steroidov v biologicheskiĭ otvet kletki-misheni.