Renal uric acid handling is not affected by beta-adrenoceptor blockade in normotensive subjects.
Nine normotensive healthy females received timolol 5 mg daily for a 4-day period and subsequently 20 mg daily for another 4-day period. None of the two dosages of timolol caused significant changes in serum uric acid or 24-h urinary fractional excretion of uric acid. Thus the increments of serum uric acid previously found in hypertensive patients is not likely to be caused by beta-adrenoceptor blockade per se.
Pedersen
O L
OL
Jacobsen
F K
FK
Stengaard-Pedersen
K
K
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008875:Middle Aged; D014527:Uric Acid / Q000378:metabolism*
D000319:Adrenergic beta-Antagonists; D014527:Uric Acid