Changes in lateral hypothalamic neuronal activity accompanying hyper- and hypoglycemias.
Blood glucose level and forebrain unit activity were simultaneously recorded in rats anesthetized with a ketamine IV infusion. Slight and transient fluctuations in glycemia, occurring either spontaneously or after IV injections of glucose or phlorizin, were observed. The spike frequency of more than 1/3 of the neurons tested in the lateral hypothalamic area was affected by these fluctuations. A majority of the responsive cells displayed either an activation during hypoglycemia or a depression during hyperglycemia. These neurons might mediate the effects of a drop in blood glucose on either meal initiation or neuroendocrine or autonomic events related to nutritional functions.
Himmi
T
T
Laboratoire de Neurobiologie, C.N.R.S., Marseille, France.
Boyer
A
A
Orsini
J C
JC
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001931:Brain Mapping; D007026:Hypothalamic Area, Lateral / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000502:physiology
D001786:Blood Glucose; D011956:Receptors, Cell Surface; C027786:glucose receptor