title: [A case of male acromegaly with galactorrhea].
abstract: A 43-year-old man was admitted to our clinic with complaints of headache and nasal obstruction. He has noted increasing hand and foot size with decreasing libido and pollakiuria for ten years. On admission, he showed galactorrhea. His visual symptoms were slightly decreased. Endocrinological evaluation revealed high serum levels of GH and prolactin. A plain skull X-ray showed acromegalic features with remarkable destruction of dorsum sellae. A contrast enhanced CT demonstrated an intrasellar high density mass extending to the sphenoid sinus and the right ethmoidal sinus. A cerebral angiogram was nor.al. Surgery was then performed with the transsphenoidal approach. A soft reddish brown mass was found in the sphenoid sinus and the bilateral cavernous sinus extending from the sella turcica. Histologically the tumor was eosinophilic adenoma. There were numerous cells exhibiting immunostaining for both GH and PRL in the immunocytochemical study. Postoperative course was uneventful. His visual impairment improved soon after the operation. Serum GH and PRL levels decreased to 38 and 130 ng/ml. He was treated with conventional irradiation (500 rads), so remained galactorrhea and hyperhidrosis. One year after the operation, there is no regrowth of the residual tumor.
authors.affiliation: Department of Neurosurgery, St. Mary's Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Tokunaga
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: E
authors.initials: E
authors.lastname: Honda
authors.forename: N
authors.initials: N
authors.lastname: Kikuchi
authors.forename: H
authors.initials: H
authors.lastname: Utsunomiya
mesh_terms: D000172:Acromegaly / Q000209:etiology* / Q000378:metabolism; D000239:Adenoma, Acidophil / Q000032:analysis / Q000150:complications* / Q000378:metabolism; D000328:Adult; D005687:Galactorrhea / Q000209:etiology* / Q000378:metabolism; D013006:Growth Hormone / Q000032:analysis / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007775:Lactation Disorders / Q000209:etiology*; D008297:Male; D010911:Pituitary Neoplasms / Q000032:analysis / Q000150:complications* / Q000378:metabolism; D011388:Prolactin / Q000032:analysis / Q000378:metabolism; D015175:Prolactinoma / Q000032:analysis / Q000150:complications / Q000378:metabolism
chemical_list: D011388:Prolactin; D013006:Growth Hormone