Unusual evolution of Wilms tumor in a patient with Wiedemann-Beckwith syndrome.
A very unusual case of Wilms tumor in a child with Wiedemann-Beckwith syndrome is presented. The patient had his first metastasis after a disease-free interval longer than three years. Later, he developed spinal epidural involvement. Both data emphasize the oncogenic potential of Wiedemann-Beckwith syndrome in children and support the contention that Wiedemann-Beckwith syndrome worsens the prognosis of Wilms tumor. Patients with Wilms tumor associated to Wiedemann-Beckwith syndrome should receive intensive therapy as well as close and prolonged follow-up in spite of apparent tumor remission.
Rey
C
C
Department of Pediatrics, N.S. Covadonga Hospital, Asturias, Spain.
del Molino
A
A
Santos
F
F
Malaga
S
S
Crespo
M
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001506:Beckwith-Wiedemann Syndrome / Q000150:complications*; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008297:Male; D009362:Neoplasm Metastasis; D009392:Nephrectomy; D013997:Time Factors; D009396:Wilms Tumor / Q000150:complications* / Q000473:pathology / Q000628:therapy