A fatality involving clomipramine.
A fatality following ingestion of the tricyclic antidepressant clomipramine (Anafranil), alprazolam (Xanax), and ethyl alcohol is described. Clomipramine and N-desmethylclomipramine were quantitated by high performance liquid chromatography and alprazolam by gas liquid chromatography. Concentrations of clomipramine and N-desmethylclomipramine were: in blood--0.84 and 1.4 mg/L; in urine--0.56 and 0.62 mg/L. Alprazolam concentration in blood was 0.069 mg/L. Ethyl alcohol was measured by headspace gas chromatography and found to be 375, 385, and 435 mg/dL in blood, urine, and vitreous humor, respectively. These findings are compared to previous reports of clomipramine related fatalities and alprazolam toxicity combined with ethyl alcohol.
Fraser
A D
AD
Isner
A F
AF
Moss
M A
MA
D000428:Alcohol Drinking; D000437:Alcoholism / Q000150:complications; D000525:Alprazolam; D014151:Anti-Anxiety Agents / Q000097:blood / Q000506:poisoning; D001569:Benzodiazepines / Q000097:blood / Q000506:poisoning; D002851:Chromatography, High Pressure Liquid; D002997:Clomipramine / Q000097:blood / Q000506:poisoning*; D000431:Ethanol / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D000431:Ethanol; D002997:Clomipramine; D000525:Alprazolam