Ovarian and peripheral steroid hormones in a case of Sertoli-Leydig cell tumor.
The clinical course, histology, and steroid secretion of a 59-year-old postmenopausal woman with a 4-yr history of virilizing well-differentiated Sertoli-Leydig cell tumor of the right ovary are reported. Hormone secretion was examined by measuring peripheral and ovarian venous gradients and pre-and postoperative levels of some delta 4 and delta 5 steroids, estrogens, gonadotropins and Sex Hormone Binding Globulin levels. The preoperative responsiveness to ACTH, dexamethasone and hCG is also reported. The results are consistent with a Sertoli-Leydig cell tumor producing mainly testosterone and, to a lesser degree, androstenedione, progesterone, estrone and 17 alpha-hydroxyprogesterone. The tumor hormone secretion may be in part responsive to hCG.
Mango
D
D
Instituto di Clinica Ginecologica ed Ostetrica, Università Cattolica del Sacro Cuore, Roma, Italy.
Scirpa
P
P
Liberati
M
M
Menini
E
E
Fabiano
A
A
Mancuso
S
S
D000324:Adrenocorticotropic Hormone; D006063:Chorionic Gonadotropin; D003907:Dexamethasone; D005260:Female; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D007430:Intraoperative Care; D007984:Leydig Cell Tumor / Q000378:metabolism* / Q000601:surgery; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000601:surgery; D010053:Ovary / Q000378:metabolism*; D011182:Postoperative Care; D012738:Sex Hormone-Binding Globulin / Q000032:analysis
D006063:Chorionic Gonadotropin; D006728:Hormones; D012738:Sex Hormone-Binding Globulin; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone