title: There is no evidence of sexual dimorphism in platelet reactivity in the rat.
abstract: Changes in platelet reactivity (in vivo) to adenosine diphosphate (ADP) were evaluated in intact male and female rats, gonadectomized rats (with or without hormonal treatment with oestradiol or testosterone), feminized and androgenized rats (with or without hormonal treatment with oestradiol and testosterone). The 3',5'-cyclic adenosine monophosphate (cAMP) content of the respective platelet suspensions was also determined simultaneously. Changes recorded in platelet reactivity to ADP showed striking changes unreflective of endocrine status. No consistent concomitant changes were observed in the cAMP content of the respective platelet suspensions. The data obtained casts doubts on the presence of sexual dimorphism in platelet reactivity. A dependence of platelet reactivity on hormones per se as well as the second messenger role for cAMP in platelet reactivity also raises some doubts.
authors.affiliation: Department of Pharmacology, King's College, University of London, UK.
authors.forename: A O
authors.initials: AO
authors.lastname: Oyekan
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D000242:Cyclic AMP / Q000097:blood; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics; D013739:Testosterone / Q000494:pharmacology
chemical_list: D012739:Gonadal Steroid Hormones; D013739:Testosterone; D004958:Estradiol; D000244:Adenosine Diphosphate; D000242:Cyclic AMP