title: [The effect of antral branch on canine antral gastrin and somatostatin concentrations in gastric vagotomy].
abstract: Three types of vagotomy: selective proximal gastric vagotomy with (SPV + P) or without (SPV) pyloroplasty and selective gastric vagotomy with pyloroplasty (SV + P) were performed on mongrel dogs, and antral immunoreactive gastrin (IRG) concentration and somatostatin like immunoreactivity (SLI) concentration were measured before and after operations. In both SPV and SPV + P groups, significant (p less than 0.01) increase in IRG concentration at the 8th and 12th postoperative weeks were observed. IRG concentration at the 12th postoperative week was significantly high (p less than 0.01) in SPV + P group compared with that in SPV group. In SV + P group, no significant change in IRG concentration was observed up to the 12th postoperative week, however, after 6th postoperative month a significant (p less than 0.01) increase was observed. SLI concentration showed no significant increase in both SPV and SV + P groups. In SPV + P group, it showed a significant (p less than 0.05) increase at the 12th postoperative week, when IRG concentration was remarkably high compared with that in the other groups. Furthermore, a significant (p less than 0.01) correlation was observed between pre- and post-operative IRG concentrations and SLI concentrations in SPV and SPV + P groups. The above results suggested that the antral branch influenced the increase in antral IRG concentration early after vagotomy and that the IRG increase might affect the increase in SLI concentration.
authors.forename: M
authors.initials: M
authors.lastname: Tsutsui
mesh_terms: D000818:Animals; D004285:Dogs; D005753:Gastric Mucosa / Q000032:analysis*; D005755:Gastrins / Q000032:analysis*; D011706:Pyloric Antrum / Q000032:analysis; D011863:Radioimmunoassay; D013004:Somatostatin / Q000032:analysis*; D014629:Vagotomy, Proximal Gastric / Q000379:methods
chemical_list: D005755:Gastrins; D013004:Somatostatin