Protective immunity against avian influenza induced by a fowlpox virus recombinant.
Fowlpox virus, the prototypic virus of the genus Avipoxvirus has a natural host range limited to avian species. As such, fowlpox virus provides a suitable candidate for the development of a species-specific recombinant viral vector. This paper reports the development of a fowlpox virus recombinant expressing the haemagglutinin molecule from a highly virulent avian influenza virus. On immunization of chickens and turkeys with the recombinant, protection is afforded against a lethal challenge with either the homologous or a heterologous influenza virus strain.
Taylor
J
J
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201.
Weinberg
R
R
Kawaoka
Y
Y
Webster
R G
RG
Paoletti
E
E
D000818:Animals; D002645:Chickens; D005455:Fluorescent Antibody Technique; D005587:Fowlpox virus / Q000235:genetics*; D006388:Hemagglutinins / Q000235:genetics*; D009975:Orthomyxoviridae; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000517:prevention & control; D011201:Poultry Diseases / Q000517:prevention & control; D011212:Poxviridae / Q000235:genetics*; D011994:Recombinant Proteins / Q000494:pharmacology; D013045:Species Specificity; D014422:Turkeys; D014611:Vaccination; D014765:Viral Vaccines / Q000627:therapeutic use*
D006388:Hemagglutinins; D011994:Recombinant Proteins; D014765:Viral Vaccines