title: Attenuation of sham feeding by naloxone is stereospecific: evidence for opioid mediation of orosensory reward.
abstract: The time course of the suppressive action of naloxone on sham feeding was examined in gastric fistulated rats. One hour sham intake of 30% sucrose solution was halved by 1.25 mg/kg IP (-)-naloxone. A maximal 75% reduction was obtained with 2.5 mg/kg. Naloxone's effect appeared to mimic the attenuation of intake rate produced by sucrose dilution. The stereoisomer (+)-naloxone (1.25, 2.5 and 10 mg/kg IP) was ineffective. These data confirm the involvement of opioid receptors in naloxone anorexia and are consistent with opioid involvement in the rewarding aspects of ingestion.
authors.affiliation: Department of Psychology, University of Birmingham, England.
authors.forename: T C
authors.initials: TC
authors.lastname: Kirkham
authors.forename: S J
authors.initials: SJ
authors.lastname: Cooper
mesh_terms: D000818:Animals; D004435:Eating / Q000187:drug effects*; D004723:Endorphins / Q000502:physiology*; D005518:Food Preferences / Q000187:drug effects; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects; D012201:Reward; D013237:Stereoisomerism; D013395:Sucrose
chemical_list: D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone; D013395:Sucrose