[Regression of left-ventricular myocardial hypertrophy in patients with hypertension during long-term treatment with beta-adrenergic blockaders].
Thirty-nine patients with second-stage essential hypertension were treated with Beta-adrenoblockers of different classes for 2.5 to 3 years. Two groups of patients were distinguished: 23 patients showing a regression of left-ventricular myocardial weight (group 1) and 16 patients without such developments (group 2). A significant decrease in arterial blood pressure (by 20-24%) and heart rate (by 15 to 18%) was recorded in both groups. Total peripheral resistance was changed insignificantly in group 1 and by 9.7% (p less than 0.05) in group 2. The end diastolic volume decreased by 5.4% (p less than 0.05) in group 1, and increased by 4.7% (p less than 0.05) in group 2. The end systolic volume decreased by 10.6% (p less than 0.05) in group 1 and increased by 5% (p greater than 0.1) in group 2. Myocardial contractility declined significantly in both groups (by 9.5% and 10.6%, respectively). Intramyocardial tension dropped by 13-20% (p less than 0.001) in both groups. Therefore, the regression of left-ventricular myocardial hypertrophy was shown to have a favorable effect on cardiac function.
Shkhvatsabaia
I K
IK
Iurenev
A P
AP
Charyev
Kh E
KhE
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001262:Atenolol / Q000008:administration & dosage; D006332:Cardiomegaly / Q000209:etiology*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009248:Nadolol; D011412:Propanolamines / Q000008:administration & dosage*; D011433:Propranolol / Q000008:administration & dosage*; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D011412:Propanolamines; D009248:Nadolol; D001262:Atenolol; D011433:Propranolol
Regressiia gipertrofii miokarda levogo zheludochka u bol'nykh gipertonicheskoĭ bolezn'iu v protesesse dlitel'nogo lecheniia beta-adrenergicheskimi blokatorami.