title: Bleeding symptoms in carriers of hemophilia A and B.
abstract: In order to investigate the bleeding tendency in clinically identified carriers of hemophilia, a self-administered questionnaire was held among 135 carriers of hemophilia A and B, 25 females with relatives with hemophilia and a matched group consisting of 60 females without relatives with hemophilia. Carriers of hemophilia appeared to suffer more often from bleeding than their relatives or the matched unrelated control group. A relation was seen between factor VIII:C or IX:C activity and the tendency to bleed. Obligatory carriers with normal factor VIII:C levels showed no bleeding tendency and were in this respect similar to a group of 25 females with relatives with hemophilia. This study shows that it is important to assay factor VIII:C or IX:C also in those women in whom the carrier status has already been established otherwise.
authors.affiliation: Van Creveld Clinic, Bilthoven, The Netherlands.
authors.forename: E P
authors.initials: EP
authors.lastname: Mauser Bunschoten
authors.forename: J C
authors.initials: JC
authors.lastname: van Houwelingen
authors.forename: E J
authors.initials: EJ
authors.lastname: Sjamsoedin Visser
authors.forename: P J
authors.initials: PJ
authors.lastname: van Dijken
authors.forename: A J
authors.initials: AJ
authors.lastname: Kok
authors.forename: J J
authors.initials: JJ
authors.lastname: Sixma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000941:Antigens / Q000032:analysis; D001760:Bleeding Time; D001777:Blood Coagulation; D002648:Child; D005164:Factor IX / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005260:Female; D008040:Genetic Linkage; D006467:Hemophilia A / Q000097:blood* / Q000235:genetics; D002836:Hemophilia B / Q000097:blood* / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008875:Middle Aged; D011795:Surveys and Questionnaires; D014960:X Chromosome
chemical_list: D000941:Antigens; D005169:Factor VIII; D005164:Factor IX