[Treatment of status epilepticus in the adult. Retrospective analysis of 192 cases treated in intensive care units].
The results of therapy have been analyzed in a series of 192 patients admitted for status epilepticus over 7 years in two intensive care units. Most (142 cases without any prior epilepsy) corresponded to secondary forms. In 2/3 of the cases, the patients were admitted because of failure of benzodiazepines and/or phenobarbitone. Sodium thiopentone achieved control of seizures in 75%; short-acting barbiturates should be especially prescribed in grand mal status with impending brain anoxia. Diphenylhydantoin would appear suitable in non-life-threatening conditions such as serial seizures or partial status. Chlormethiazole often succeeds in controlling convulsive status which has proved refractory to other treatment. Supportive management is mandatory: 52% of patients required respiratory assistance. Fatalities (36%) exclusively correspond to the underlying cerebral conditions and systemic disorders.
Nouailhat
F
F
Lévy-Alcover
M A
MA
Goulon
M
M
D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D001569:Benzodiazepines; D002719:Chlormethiazole / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000627:therapeutic use; D012121:Respiration, Artificial; D013226:Status Epilepticus / Q000401:mortality / Q000628:therapy*; D013874:Thiopental / Q000627:therapeutic use
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D002719:Chlormethiazole; D001569:Benzodiazepines; D010672:Phenytoin; D013874:Thiopental
Traitement de l'etat de mal épileptique de l'adulte. Analyse rétrospect 192 cas traités en réanimation.