title: The active principles of the branchlet and hook of Uncaria sinensis Oliv. examined with a 5-hydroxytryptamine receptor binding assay.
abstract: Of the alkaloids obtained from Uncaria sinensis Oliv., geissoschizine methyl ether, corynantheine and dihydrocorynantheine decreased specific [3H]5-HT binding to membrane preparations from rat brain and from in-vitro experiments on guinea-pig ileum, these alkaloids were found to be partial agonists for 5-HT receptors. Therefore, they might be useful in the treatment of diseases resulting from disorders of 5-HT metabolism.
authors.forename: H
authors.initials: H
authors.lastname: Kanatani
authors.forename: H
authors.initials: H
authors.lastname: Kohda
authors.forename: K
authors.initials: K
authors.lastname: Yamasaki
authors.forename: I
authors.initials: I
authors.lastname: Hotta
authors.forename: Y
authors.initials: Y
authors.lastname: Nakata
authors.forename: T
authors.initials: T
authors.lastname: Segawa
authors.forename: E
authors.initials: E
authors.lastname: Yamanaka
authors.forename: N
authors.initials: N
authors.lastname: Aimi
authors.forename: S
authors.initials: S
authors.lastname: Sakai
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D010946:Plants, Medicinal / Q000032:analysis*; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*
chemical_list: D000470:Alkaloids; D011985:Receptors, Serotonin