[Contraction of the isolated stomach of the rat as a result of stimulation of postganglionic fibers in the presence of 4-methylesculetol].
It is known that the bioflavonoids as the Ca++ have an enhancing effect on the transmitter release in different cholinergic nerve-endings. For this reason, it is seemed interesting to study the influence of the separately tested 4-methylesculetin or associated with the ascorbic acid and comparatively the Ca++ concentration increase on the isolated rat stomach response by electrical transmural stimulation achieved in presence or absence of hexamethonium. Both the 4-methylesculetin and the ascorbic acid have always increased the response of the preparation submitted to electrical transmural stimulation. The 4-methylesculetin effect resulted particularly strong if the substance was employed with the ascorbic acid. The enhancing effect of the 4-methylesculetin, obtained with or without the ascorbic acid, is resulted comparatively lesser in presence of hexamethonium. On the basis of the evident analogy between the 4-methylesculetin effects and the ones determined by the increased Ca++ concentration, it can be supposed that the bioflavonoid facilitates the transmitter release in the pre- and postganglionic nerve-endings. The results here reported, confirm other previous observations accomplished on different cholinergic nerve-endings and could substain the hypothesis according to which the 4-methylesculetin increase the Ca++ transport through the biological membranes.
Aragno
R
R
Bettini
V
V
Bruni
G
G
Mayellaro
F
F
Ton
P
P
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001338:Autonomic Fibers, Postganglionic / Q000502:physiology; D002118:Calcium / Q000494:pharmacology; D004347:Drug Interactions; D004558:Electric Stimulation; D005769:Gastrointestinal Motility / Q000187:drug effects*; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D051381:Rats; D012603:Scopoletin / Q000494:pharmacology*; D014468:Umbelliferones / Q000494:pharmacology*; D014630:Vagus Nerve / Q000502:physiology*
D006584:Hexamethonium Compounds; D014468:Umbelliferones; D018738:Hexamethonium; D012603:Scopoletin; D001205:Ascorbic Acid; D002118:Calcium
Contrazione dello stomaco isolato di ratto per stimolazione di fibre post-gangliari, in presenza di 4-metilesculetolo.