Effects of 6-hydroxydopamine-induced lesions of the paraventricular nucleus, and of prazosin, on the corticosterone response to restraint in rats.
In rats, with bilateral lesions of the paraventricular nuclei induced by 6-hydroxydopamine, restraint stress failed to elevate levels of corticosterone in plasma, although the resting levels in lesioned animals were similar to those of control rats. Prazosin inhibited the plasma-corticosterone response to restraint in intact rats, at doses which did not by themselves influence resting hormone levels. These results suggest a positive role for noradrenaline, acting through alpha-adrenoceptors, on the stress-induced output of corticotrophin.
Gibson
A
A
Hart
S L
SL
Patel
S
S
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology*; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects*; D011224:Prazosin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*
D000317:Adrenergic alpha-Antagonists; D001679:Biogenic Amines; D006892:Hydroxydopamines; D016627:Oxidopamine; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone; D009638:Norepinephrine; D011224:Prazosin