Bradykinin action in the rat duodenum: influence of a duodenum contracting bradykinin partial sequence on the cAMP level.
A modified bradykinin partial sequence (PP) contracts the isolated rat duodenum, inhibits the adenylate cyclase activity and decreases the cAMP level. These effects are dependent on the presence of free Ca++. The PP acts in contrast to bradykinin itself, which relaxes the rat duodenum and stimulates adenylate cyclase. The results further support the involvement of both cAMP and Ca++ in bradykinin action on rat duodenum smooth muscle.
Liebmann
C
C
Department of Biology, Friedrich Schiller-University Jena, GDR.
Reissmann
S
S
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D002462:Cell Membrane / Q000201:enzymology; D000242:Cyclic AMP / Q000378:metabolism*; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism*; D004533:Egtazic Acid / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D009842:Oligopeptides / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D009842:Oligopeptides; D004533:Egtazic Acid; C058929:phenylalanyl-glycyl-prolyl-phenylalanyl-arginine; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D001920:Bradykinin; D002118:Calcium