A repeat sequence, GGGTTA, is shared by DNA of human herpesvirus 6 and Marek's disease virus.
Some regions of the genomes of human B-lymphotrophic virus (HBLV), also designated as human herpesvirus 6, and Marek's disease virus were found to hybridize to each other under moderate to stringent conditions, scoring from 10 to 30% base-pair mismatch. Nucleotide sequence analysis showed that a 6-base-pair repetitive sequence, GGGTTA (DR2), present in the IRS-IRL junction region of the Marek's disease virus genome, was also reiterated in the HBLV genome. The function(s) of such a sequence is unknown, but this is the first report of homology between HBLV and a nonhuman herpesvirus.
Kishi
M
M
Department of Virology, Showa University Research Institute for Biomedicine in Florida, St. Petersburg 33716.
Harada
H
H
Takahashi
M
M
Tanaka
A
A
Hayashi
M
M
Nonoyama
M
M
Josephs
S F
SF
Buchbinder
A
A
Schachter
F
F
Ablashi
D V
DV
D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D003429:Cross Reactions; D015342:DNA Probes; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000235:genetics*; D015245:Deoxyribonuclease BamHI; D006564:Herpesviridae / Q000235:genetics*; D008381:Herpesvirus 2, Gallid / Q000235:genetics*; D006801:Humans; D009693:Nucleic Acid Hybridization; D012091:Repetitive Sequences, Nucleic Acid
D015342:DNA Probes; D004279:DNA, Viral; D004262:DNA Restriction Enzymes; D015245:Deoxyribonuclease BamHI