title: Pathological features of invasive breast cancer associated with a high risk of local recurrence after tumour excision and radical radiotherapy.
abstract: The histological slides of 273 breast cancer patients, treated by local excision and radiotherapy and followed up for 2-6 years, were reviewed in search of factors predictive of local recurrence. Local recurrence was found to be most closely related to the combination of a high proportion of intraduct carcinoma and extensive necrosis (comedocarcinoma). This latter group of 18 patients had a local recurrence rate of 50%. These patients are of particular interest since they form a small group with readily identifiable histological features.
authors.affiliation: Westminster Hospital, London.
authors.forename: A S
authors.initials: AS
authors.lastname: Bulman
authors.forename: R P
authors.initials: RP
authors.lastname: Lindley
authors.forename: P
authors.initials: P
authors.lastname: Parsons
authors.forename: H
authors.initials: H
authors.lastname: Ellis
mesh_terms: D001941:Breast Diseases / Q000473:pathology*; D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D012307:Risk Factors