Blood pressure and catecholamines following exercise during selective beta-blockade in hypertension.
This study examines and compares the hemodynamic and sympathoadrenal response to bicycle exercise in hypertensive subjects during two weeks' treatment with a cardio-selective (metoprolol) and nonselective (propranolol) beta-blocker. The increase in plasma norepinephrine and epinephrine concentration following exercise was augmented to a similar degree with each beta-blocker. Pre-exercise blood pressure and heart rate were similar for the two drugs. However immediately after exercise and particularly after resting for 20 min post exercise, diastolic blood pressure was lower during metoprolol treatment. Systolic blood pressure was also lower 20 min post exercise during metoprolol treatment. These observations indicate that cardio-selective beta-blockers offer advantages in blood pressure control during exercise through intact vascular beta 2-adrenoceptors opposing sympathetically mediated vasoconstriction.
Vandongen
R
R
Margetts
B
B
Beilin
L J
LJ
deKlerk
N
N
Rogers
P
P
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000097:blood*; D004837:Epinephrine / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D009638:Norepinephrine / Q000097:blood; D005082:Physical Exertion; D011433:Propranolol / Q000627:therapeutic use; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D011433:Propranolol; D008790:Metoprolol; D009638:Norepinephrine; D004837:Epinephrine