Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis.
10 out of 17 (59%) patients with tropical spastic paraparesis (TSP) had antibodies to human T-lymphotropic virus-I (HTLV-I), as did 5 out of 5 TSP patients with systemic symptoms. Only 13 out of 303 (4%) controls, made up of blood donors, medical personnel, and other neurological patients, had such antibodies. These findings suggest either that HTLV-I is neurotropic or that the virus or a related one contributes to the pathogenesis of TSP.
Gessain
A
A
Barin
F
F
Vernant
J C
JC
Gout
O
O
Maurs
L
L
Calender
A
A
de Thé
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis* / Q000134:cerebrospinal fluid; D000956:Antigens, Viral / Q000032:analysis; D017977:Deltaretrovirus / Q000276:immunology* / Q000302:isolation & purification; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008395:Martinique; D008875:Middle Aged; D009128:Muscle Spasticity / Q000209:etiology / Q000382:microbiology; D010264:Paraplegia / Q000209:etiology / Q000382:microbiology*; D014329:Tropical Climate
D000914:Antibodies, Viral; D000956:Antigens, Viral