Effect of recombinant murine interferon-beta on the replication of murine cytomegalovirus.
Pretreatment of mouse embryo fibroblasts (MEF) with recombinant murine interferon-beta (rMuIFN-beta) induced a high level of intracellular 2',5'-oligoadenylate (2-5A) synthetase activity. However, murine cytomegalovirus (MCMV) replicated under such condition, indicating that MCMV is relatively insensitive in vitro to rMuIFN-beta. Thus, there was a dissociation of 2-5A synthetase activity and antiviral activity against MCMV. In contrast to MCMV, the two parameters were closely associated in the case of vesicular stomatitis virus (VSV).
Nakamura
K
K
Department of Microbiology, Miyazaki Medical College.
Eizuru
Y
Y
Minamishima
Y
Y
D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects* / Q000502:physiology; D007370:Interferon Type I / Q000494:pharmacology*; D051379:Mice; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
D007370:Interferon Type I; D015088:2',5'-Oligoadenylate Synthetase