Characterization of adrenergic receptors on proximal tubular basolateral membranes.
Alpha adrenergic receptors are identified on basolateral plasma membranes derived from proximal tubular epithelial cells. The density of alpha 2 receptors was over two-fold greater than alpha 1 receptors. The basolateral membranes were devoid of beta receptors. These results support previous demonstrations of alpha adrenergic receptors in rat renal cortex and concur with studies which suggest a limited presence of beta receptors on rat proximal tubules.
Jensen
R E
RE
University of Nebraska Medical Center, Department of Pharmacology, College of Medicine, Omaha 68105.
Berndt
W O
WO
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003000:Clonidine / Q000378:metabolism; D004082:Dihydroalprenolol / Q000378:metabolism; D004088:Dihydroergotoxine / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D011224:Prazosin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*
D011942:Receptors, Adrenergic, alpha; D004088:Dihydroergotoxine; D004082:Dihydroalprenolol; D003000:Clonidine; D011224:Prazosin