Time course of action of combinations of vecuronium and pancuronium.
Vecuronium 0.1 mg/kg, pancuronium 0.1 mg/kg, vecuronium 0.075 mg/kg + pancuronium 0.025 mg/kg, vecuronium + pancuronium 0.05 mg/kg each and vecuronium 0.025 mg/kg + pancuronium 0.075 mg/kg were compared with respect to time taken to onset of effect, duration of clinical relaxation and intubation conditions in five groups of 20 patients each. The time to onset and intubating conditions were similar in all the groups, indicating that the combinations have no advantage over the individual drugs. The duration of clinical relaxation was 25 minutes with vecuronium, and increased as the proportion of pancuronium in the mixture increased, being 56 minutes with pancuronium 0.1 mg/kg.
Pandit
S K
SK
Ferres
C J
CJ
Gibson
F M
FM
Mirakhur
R K
RK
D000293:Adolescent; D000328:Adult; D000368:Aged; D004338:Drug Combinations; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013997:Time Factors; D014673:Vecuronium Bromide
D004338:Drug Combinations; D009466:Neuromuscular Blocking Agents; D014673:Vecuronium Bromide; D010197:Pancuronium