title: Kindling-like stimulus patterns induce epileptiform discharges in the guinea pig in vitro hippocampus.
abstract: In the guinea pig in vitro hippocampal slice preparation, we have demonstrated that the repeated tetanic stimulation of the Schaffer collateral-commissural input to CA1 pyramidal neurones produces a progressive increase in the amplitude and duration of postsynaptic potentials, and stimulus-induced and spontaneous paroxysmal depolarization shifts (PDSs). Both the enhancement of synaptic transmission and the genesis of PDSs were reversibly blocked by the N-methyl-D-aspartate (NMDA) receptor antagonist (+/-)-2-amino-5-phosphonovalerate (APV). These results provide evidence that progressive, stimulation-induced long-term potentiation may serve as the trigger for kindling-induced epileptogenesis, and this process is dependent on the repeated activation of an APV-sensitive receptor.
authors.forename: N T
authors.initials: NT
authors.lastname: Slater
authors.forename: A
authors.initials: A
authors.lastname: Stelzer
authors.forename: M
authors.initials: M
authors.lastname: Galvan
mesh_terms: D015763:2-Amino-5-phosphonovalerate; D000818:Animals; D004558:Electric Stimulation; D004827:Epilepsy / Q000209:etiology*; D006168:Guinea Pigs; D006624:Hippocampus / Q000503:physiopathology*; D066298:In Vitro Techniques; D007696:Kindling, Neurologic; D008564:Membrane Potentials; D009434:Neural Pathways / Q000503:physiopathology; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission; D014633:Valine / Q000031:analogs & derivatives
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D015763:2-Amino-5-phosphonovalerate; D014633:Valine