Assignment of the human tyrosine aminotransferase gene to chromosome 16.
The liver enzyme tyrosine aminotransferase (TAT; EC 2.6.1.5) catalyzes the rate-limiting step in the catabolic pathway of tyrosine. Deficiency in TAT enzyme activity underlies the autosomally inherited disorder tyrosinemia II (Richner-Hanhart syndrome). Using a human TAT cDNA clone as hybridization probe, we have determined the chromosomal location of the TAT structural gene by Southern blot analysis of DNAs from a series of human X rodent somatic cell hybrids. The results assign the TAT gene to human chromosome 16.
Natt
E
E
Kao
F T
FT
Rettenmeier
R
R
Scherer
G
G
D000818:Animals; D002874:Chromosome Mapping; D002902:Chromosomes, Human, 16-18; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D009693:Nucleic Acid Hybridization; D051381:Rats; D014444:Tyrosine Transaminase / Q000235:genetics*
D005819:Genetic Markers; D004247:DNA; D014444:Tyrosine Transaminase; D004262:DNA Restriction Enzymes