Effects of DOCA and salt intake on body sodium, fluid intake, blood pressure and excretion of a sodium load in rats.
Body sodium was measured repeatedly by a whole-body counting method (22Na) in control and deoxycorticosterone acetate (DOCA)-treated Wistar rats taking a sodium-free pelleted diet and drinking a choice of H2O and either 0.5% NaCl or 0.1% NaCl (n = 11 per group, four groups). Body sodium was higher in DOCA-treated than in control rats and higher in rats on 0.5% NaCl than in those on 0.1% NaCl. These differences persisted even when all sodium intake was stopped. An intraperitoneal NaCl load was excreted at least as rapidly by the DOCA-treated as by the control rats. Commencement of excretion was slower in the rats on 0.1% NaCl than in those on 0.5% NaCl. It is concluded that DOCA raises the basal level of body sodium but does not slow down the excretion of sodium in the body in excess of the basal level.
Simpson
F O
FO
Wellcome Medical Research Institute, University of Otago Medical School, Dunedin, New Zealand.
Ledingham
J M
JM
Paulin
J M
JM
Purves
R D
RD
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003900:Desoxycorticosterone / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000378:metabolism* / Q000652:urine; D012982:Sodium, Dietary / Q000008:administration & dosage*
D012982:Sodium, Dietary; D003900:Desoxycorticosterone; D012964:Sodium