Changes in dynorphin, enkephalin and cholecystokinin content of hippocampus and substantia nigra after amygdala kindling.
Amygdaloid kindling of rats produced an increase in hippocampal Met5-enkephalin-Arg6-Gly7-Leu8 and cholecystokinin immunoreactivities and simultaneously a decrease in dynorphin A1-8 content. In substantia nigra Met5-enkephalin-Arg6-Gly7-Leu8 was increased and no change was observed in dynorphin A1-8 content. These data suggest that specific alterations of neuropeptides in limbic and extrapyramidal circuits are prominent manifestations of the kindling process or kindled seizures.
Iadarola
M J
MJ
Shin
C
C
McNamara
J O
JO
Yang
H Y
HY
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D002766:Cholecystokinin / Q000032:analysis; D004399:Dynorphins / Q000032:analysis; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives / Q000032:analysis; D006624:Hippocampus / Q000032:analysis*; D007696:Kindling, Neurologic; D008297:Male; D010446:Peptide Fragments / Q000032:analysis; D010455:Peptides / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000032:analysis*
D010446:Peptide Fragments; D010455:Peptides; D004744:Enkephalin, Methionine; D004399:Dynorphins; C026770:dynorphin (1-8); C033453:enkephalin-Met, Arg(6)-Gly(7)-Leu(8)-; D002766:Cholecystokinin