title: Ageing and alpha-adrenoceptors.
abstract: Ageing changes in alpha-adrenoceptors can be summarized as follows: except in the eye, where there is an apparent increased responsiveness with increasing age in man, peripheral alpha-adrenoceptor responsiveness has generally been found to be either unchanged or reduced with increasing age in animals and man. Even where changes have been found it remains to be clarified whether these changes are selective changes in alpha-receptors or whether they are due to alterations in responsiveness beyond the level of the receptor.
authors.forename: J R
authors.initials: JR
authors.lastname: Docherty
authors.forename: K
authors.initials: K
authors.lastname: O'Malley
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000375:Aging; D000818:Animals; D001011:Aorta; D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D011680:Pupil; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D012501:Saphenous Vein; D014649:Vas Deferens; D014991:Xylazine / Q000494:pharmacology
chemical_list: D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D011942:Receptors, Adrenergic, alpha; D014991:Xylazine; D009638:Norepinephrine