title: Adenylate cyclase and alpha-2-adrenoceptors in thrombocytes of chronic uremic patients.
abstract: Thrombocyte adenylate cyclase regulation and alpha-2-adrenoceptors have been studied in uremic patients as well as in healthy controls. Stimulation of adenylate cyclase activity by PGE1 and forskolin as well as inhibition by (+/-)-epinephrine was not significantly different between both groups. Additionally, there was no evidence of an alteration of the thrombocyte alpha-2-adrenoceptor density, determined by 3H-rauwolscine binding as suggested by others.
authors.affiliation: Center of Internal Medicine, Justus Liebig University, Giessen, FRG.
authors.forename: F
authors.initials: F
authors.lastname: Lübbecke
authors.forename: J
authors.initials: J
authors.lastname: Sandelbaum
authors.forename: G
authors.initials: G
authors.lastname: Schütterle
authors.forename: V
authors.initials: V
authors.lastname: Wizemann
mesh_terms: D000262:Adenylyl Cyclases / Q000032:analysis / Q000097:blood*; D000328:Adult; D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D014511:Uremia / Q000097:blood*
chemical_list: D011942:Receptors, Adrenergic, alpha; D000262:Adenylyl Cyclases