[Differences in the mechanisms of the stimulant and antidepressive effects of nomifensine].
Four effects of nomifensine were studied in interaction with a dopamine receptor blocker (pimozide) and a beta-adrenergic receptor blocker (propranolol). The effects of nomifensine were divided into two categories: 1. Psychomotor stimulant effect a) Stimulation of locomotor activity in mice b) Stereotyped behavior in rats 2. Antidepressant effect a) Antagonism of hypothermia caused by reserpine in mice b) Potentiation of yohimbine-induced toxicity in mice. The psychomotor stimulant effects were antagonized by pimozide but not by propranolol. The antidepressant effects were antagonized by propranolol but not by pimozide. Our results support the hypothesis that nomifensine acts via both dopaminergic and noradrenergic mechanisms subserving distinct behavioral effects, psychomotor stimulant and antidepressant, respectively.
Chermat
R
R
Poncelet
M
M
Simon
P
P
D000818:Animals; D000928:Antidepressive Agents; D001831:Body Temperature / Q000187:drug effects; D000697:Central Nervous System Stimulants; D004298:Dopamine / Q000502:physiology; D004347:Drug Interactions; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009627:Nomifensine / Q000494:pharmacology*; D009638:Norepinephrine / Q000502:physiology; D010868:Pimozide; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects; D015016:Yohimbine / Q000494:pharmacology / Q000633:toxicity
D000928:Antidepressive Agents; D000697:Central Nervous System Stimulants; D007546:Isoquinolines; D010868:Pimozide; D009627:Nomifensine; D015016:Yohimbine; D012110:Reserpine; D011433:Propranolol; D004298:Dopamine; D009638:Norepinephrine
Différence dans le mécanisme des effets stimulants et antidépresseurs de la nomifensine.