[Effect of cholino- and adrenomimetic substances on B-lymphocyte proliferation in mice during a primary immune response to a protein antigen].
A study was made of the effects of the neurotransmitters acetylcholine and adrenaline on proliferation of B lymphocytes of mice immunized with ovalbumin. The neurotransmitters were noticed to be capable of changing B cell proliferation on cultivation in vitro. The effect (an increase or reduction of 3H-thymidine incorporation) depended on the time of immunization, antigen dose, and the type of a neurotransmitter. On the whole the pattern of the acetylcholine effect correlated with a natural trend of changes in B lymphocyte proliferation at different times of the immune response. Adrenaline produced a reciprocal effect.
Ado
A D
AD
Gol'dshteĭn
M M
MM
Dontsov
V I
VI
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D018377:Neurotransmitter Agents / Q000494:pharmacology; D010047:Ovalbumin / Q000276:immunology*; D010277:Parasympathomimetics / Q000494:pharmacology*; D013566:Sympathomimetics / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
D018377:Neurotransmitter Agents; D010277:Parasympathomimetics; D013566:Sympathomimetics; D010047:Ovalbumin; D013936:Thymidine
Vliianie kholino- i adrenomimeticheskikh veshchestv na proliferatsiiu B-limfotsitov myshi vo vremia pervichnogo immunnogo otveta na belkovyĭ antigen.