Dementia-like, largely reversible syndrome after cranial irradiation and prolonged interferon treatment.
An elderly man with small cell lung cancer developed a largely reversible, dementia-like syndrome after cranial irradiation and prolonged treatment with interferon (IFN). The development of the symptoms started 2 months after cranial irradiation following more than 2 years of IFN treatment. The behavioral impairment did not suggest any specific brain localization. The dementia-like behaviour may be due to a combined effect of irradiation and IFN.
Laaksonen
R
R
Department of Neurology, University Central Hospital, Helsinki, Finland.
Niiranen
A
A
Iivanainen
M
M
Mattson
K
K
Holsti
L
L
Färkkilä
M
M
Cantell
K
K
D000368:Aged; D001921:Brain / Q000528:radiation effects*; D018288:Carcinoma, Small Cell / Q000628:therapy; D003704:Dementia / Q000209:etiology*; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000628:therapy; D008297:Male; D011581:Psychological Tests; D013997:Time Factors
D007370:Interferon Type I