title: Disseminated aspergillosis in a patient with bronchiectasis. A 15-month clinical and immunological follow-up.
abstract: We report a case of disseminated aspergillosis involving both lung and brain in an adult female patient affected with bronchiectasis. Immunological follow-up was conducted before the clinical diagnosis and during the illness and revealed an excessively high helper-inducer/cytotoxic-suppressor (T4/T8) ratio. Peripheral granulocyte function was normal. A progressive reduction of lung and brain localizations was obtained with antifungal therapy and Imuthiol, an immunopotentiator which regulates the ratio of T-cell subsets. T4/T8 ratio returned to average values. The patient is alive 12 months after the diagnosis.
authors.forename: E
authors.initials: E
authors.lastname: Lemarié
authors.forename: B
authors.initials: B
authors.lastname: Lemaire
authors.forename: D
authors.initials: D
authors.lastname: Saudeau
authors.forename: M
authors.initials: M
authors.lastname: Lavandier
authors.forename: M
authors.initials: M
authors.lastname: Renoux
authors.forename: G
authors.initials: G
authors.lastname: Renoux
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D001228:Aspergillosis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D001927:Brain Diseases / Q000150:complications; D001987:Bronchiectasis / Q000150:complications* / Q000276:immunology; D004050:Ditiocarb / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005437:Flucytosine / Q000008:administration & dosage; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000666:Amphotericin B; D004050:Ditiocarb; D005437:Flucytosine