title: Autoimmune basis for visual paraneoplastic syndrome in patients with small-cell lung carcinoma.
abstract: Unexplained neurological disorders sometimes develop in patients with cancer, even when the primary tumour or its metastases have not invaded the central nervous system. Visual dysfunction in patients with small-cell carcinoma of the lung is one of these paraneoplastic syndromes and is associated with serum auto-antibodies which react with specific subsets of retinal neurons. These sera have now been shown to react with cell lines derived from small-cell carcinoma. The antibodies recognise a small number of antigens shared by retinal and tumour cells, suggesting that an autoimmune response may be triggered by the tumour.
authors.forename: G B
authors.initials: GB
authors.lastname: Grunwald
authors.forename: R
authors.initials: R
authors.lastname: Klein
authors.forename: M A
authors.initials: MA
authors.lastname: Simmonds
authors.forename: S E
authors.initials: SE
authors.lastname: Kornguth
mesh_terms: D000368:Aged; D000941:Antigens / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology; D018288:Carcinoma, Small Cell / Q000276:immunology*; D006801:Humans; D008297:Male; D010257:Paraneoplastic Syndromes / Q000276:immunology*; D012160:Retina / Q000276:immunology; D014786:Vision Disorders / Q000276:immunology*
chemical_list: D000941:Antigens; D001323:Autoantibodies