Effect of nedocromil sodium on the airway response to inhaled capsaicin in normal subjects.
In six normal subjects treatment with 4 mg nedocromil sodium failed to alter the cough and bronchoconstriction induced by inhaled capsaicin. Because nedocromil has previously been shown to inhibit reflex bronchoconstriction provoked by inhaled sulphur dioxide and inhaled bradykinin, the results suggest that inhaled capsaicin acts on different nerve fibres.
Hansson
L
L
Department of Clinical Pharmacology, Royal Postgraduate Medical School, London.
Choudry
N B
NB
Fuller
R W
RW
Pride
N B
NB
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D002211:Capsaicin / Q000494:pharmacology*; D003371:Cough / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D017835:Nedocromil; D015363:Quinolones / Q000494:pharmacology*
D015363:Quinolones; D017835:Nedocromil; D002211:Capsaicin