title: Atrial natriuretic peptide concentration and natriuretic hormone activity in plasma of patients with chronic renal failure.
abstract: To elucidate further the possible role of atrial natriuretic peptide (ANP) and hypothetical natriuretic hormone (NH) in volume and BP regulation in chronic renal failure (CRF) we measured plasma ANP, digitalis-like substances (DLS) and Na+-K+-ATPase activity (using 86Rb influx into RBC) in 9 patients with CRF before and after hemodialysis. Volume expansion between consecutive dialyses led in all patients to the elevation of plasma ANP (83.4 +/- 14.2 pmol/l) reaching in some overhydrated subjects and/or patients with concomitant cardiac insufficiency concentration greater than 150 pmol/l. Reduced 86Rb influx into RBC before hemodialysis (37.7 +/- 4.9% of controls) was accompanied by higher DLS concentrations (201 +/- 32 pmol/l). Ultrafiltration during hemodialysis with ECFV reduction lowered both ANP and DLS concentrations to 28.1 +/- 9.4 pmol/l and to 151 +/- 23 pmol/l, respectively, and abolished partly the inhibition of Na+-K+-ATPase activity (64.9 +/- 7.6% of controls). These changes corresponded to the degree of ECFV alteration. Our results suggest that both natriuretic principles are activated during ECFV expansion in CRF, probably as a corrective mechanism, with a tendency to normalize when ECFV is reduced during hemodialysis.
authors.affiliation: Laboratory for Endocrinology and Metabolism, Charles University Faculty of Medicine, Prague, Czechoslovakia.
authors.forename: K
authors.initials: K
authors.lastname: Horký
authors.forename: J
authors.initials: J
authors.lastname: Widimský
authors.forename: J
authors.initials: J
authors.lastname: Srámková
authors.forename: J
authors.initials: J
authors.lastname: Lachmanová
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism; D002298:Cardenolides; D004077:Digoxin; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D045283:Natriuretic Agents / Q000097:blood*; D006435:Renal Dialysis; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000097:blood
chemical_list: D001798:Blood Proteins; D002298:Cardenolides; D045283:Natriuretic Agents; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D009320:Atrial Natriuretic Factor; D000254:Sodium-Potassium-Exchanging ATPase