The effect of dopamine antagonists in spontaneous and tardive dyskinesia.
Dopamine antagonists are effective in suppressing hyperkinetic symptoms in patients with tardive dyskinesia, spontaneous oral dyskinesia, Huntington's chorea, and Gilles de la Tourette's syndrome. These neuroleptics have no curative effect upon the conditions and may even aggravate symptoms in the long term. In many cases a single neuroleptic drug may lose its effect. A more lasting effect may be obtained by combining drugs with pre- and postsynaptic antidopamine effects.
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D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D018492:Dopamine Antagonists; D004305:Dose-Response Relationship, Drug; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy*; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy; D007980:Levodopa / Q000627:therapeutic use; D011954:Receptors, Dopamine / Q000187:drug effects; D005879:Tourette Syndrome / Q000188:drug therapy
D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D007980:Levodopa