Influence of angiotensin II (AII) and angiotensin I (AI) on renal renin synthesis and release.
This study examined the effect of exogenous AI and AII on renin synthesis and release. AII or AII + AI were given using osmotic minipumps, over a 7 day period to rats receiving oral Enalapril. Enalapril caused a marked increase in renin release and synthesis. AII abolished the rise in plasma and renal renin observed with Enalapril. AI had no inhibitory or stimulatory effect on renin release or synthesis in rats receiving Enalapril and AII.
Barrett
G L
GL
Department of Physiology, University of Melbourne, Parkville, Australia.
Morgan
T O
TO
Smith
M
M
D000803:Angiotensin I / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D004656:Enalapril / Q000037:antagonists & inhibitors*; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000096:biosynthesis* / Q000378:metabolism
D000804:Angiotensin II; D004656:Enalapril; D000803:Angiotensin I; D012083:Renin