[Long-term observation on transplanted tumors of human intestinal mucoid adenocarcinoma in nude mice].
Long-term observation on transplanted tumor of human intestinal mucoid adenocarcinoma in nude mice is reported. The transplanted tumor which has been passed 57 passages in 151 nude mice with transplant survival rate of 99.34% in more than 5 years is the tumor with the utmost number of passages domestically undertaken as yet. During the long-term observation, the transplanted tumor was not only identical to the primary tumor in histopathology, ultrastructure and chromosome pattern, but also constant in biological characteristics, such as secretion of mucin and production of carcinoembryonic antigen. These tumor cells were able to combine with CEA mcAb specifically by obviously showing the scanning image of transplanted tumor of human intestinal mucoid adenocarcinoma in nude mice with 131I-CEAmcAb. The roles of the transplanted tumor model in cancer research are discussed.
Sun
Y K
YK
Institute of Basic Medical Sciences, Beijing University of Medical Sciences.
D002288:Adenocarcinoma, Mucinous / Q000032:analysis / Q000473:pathology*; D000818:Animals; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000032:analysis / Q000473:pathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009077:Mucins / Q000032:analysis; D009368:Neoplasm Transplantation
D002272:Carcinoembryonic Antigen; D009077:Mucins