Effects of substituted phenylethylamines on blowfly feeding behavior.
The pharmacology of adult Phormia regina (Meigen) feeding behavior was explored by injecting candidate drugs into starved blowflies and then determining their responsiveness to aqueous sucrose, via the proboscis extension reflex. d-Amphetamine caused responsiveness to fall dramatically, while related drugs and biogenic amines had varying effects. When d-amphetamine-treated flies were fed 1 M sucrose, they consumed significantly more than control flies. Electrophysiological studies demonstrated that the responses of tarsal sugar receptor neurons to aqueous sucrose were not significantly altered by d-amphetamine. These observations are compatible with our hypothesis that octopamine positively modulates blowfly feeding behavior and suggest that other aromatic biogenic amines affect feeding behavior in this insect.
Long
T F
TF
Edgecomb
R S
RS
Murdock
L L
LL
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D050260:Carbohydrate Metabolism; D003913:Dextroamphetamine / Q000494:pharmacology; D004175:Diptera / Q000502:physiology*; D004594:Electrophysiology; D005247:Feeding Behavior / Q000187:drug effects*; D010627:Phenethylamines / Q000494:pharmacology*; D013997:Time Factors
D001679:Biogenic Amines; D010627:Phenethylamines; D003913:Dextroamphetamine