Reduction of (3H)-imipramine binding sites on platelets of conduct-disordered children.
Binding characteristics of tritiated imipramine on blood platelets were determined in daytime hospitalized prepubertal children who had mixed diagnoses of conduct disorder (CD) plus attention deficit disorder hyperactivity (ADDH) and in inpatient adolescents who had a history of aggressive behavior. The number of (3H)-imipramine maximal binding sites (Bmax) was significantly lower in the prepubertal patient group of CD plus ADDH; the dissociation constant (Kd) was not significantly different. There were significant negative correlations between Bmax and the Externalizing or Aggressive factors of the Child Behavior Checklist when the CD plus ADDH prepubertal patients were combined with their matched controls and within the adolescent inpatient group. We propose that a decreased platelet imipramine binding Bmax value, as an index of disturbed presynaptic serotonergic activity, is not specific to depression and may be used as a biologic marker for the lack of behavioral constraint in heterogeneous. populations of psychiatric patients.
Stoff
D M
DM
Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Department of Psychiatry, Philadelphia.
Pollock
L
L
Vitiello
B
B
Behar
D
D
Bridger
W H
WH
D000293:Adolescent; D000294:Adolescent Behavior; D000374:Aggression; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D002462:Cell Membrane / Q000378:metabolism; D002648:Child; D002653:Child Behavior Disorders / Q000097:blood*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood*; D007604:Juvenile Delinquency; D008297:Male; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism; D012016:Reference Values
D015415:Biomarkers; D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; D011985:Receptors, Serotonin; C027775:imipramine receptor; D007099:Imipramine