title: Dementia-like, largely reversible syndrome after cranial irradiation and prolonged interferon treatment.
abstract: An elderly man with small cell lung cancer developed a largely reversible, dementia-like syndrome after cranial irradiation and prolonged treatment with interferon (IFN). The development of the symptoms started 2 months after cranial irradiation following more than 2 years of IFN treatment. The behavioral impairment did not suggest any specific brain localization. The dementia-like behaviour may be due to a combined effect of irradiation and IFN.
authors.affiliation: Department of Neurology, University Central Hospital, Helsinki, Finland.
authors.forename: R
authors.initials: R
authors.lastname: Laaksonen
authors.forename: A
authors.initials: A
authors.lastname: Niiranen
authors.forename: M
authors.initials: M
authors.lastname: Iivanainen
authors.forename: K
authors.initials: K
authors.lastname: Mattson
authors.forename: L
authors.initials: L
authors.lastname: Holsti
authors.forename: M
authors.initials: M
authors.lastname: Färkkilä
authors.forename: K
authors.initials: K
authors.lastname: Cantell
mesh_terms: D000368:Aged; D001921:Brain / Q000528:radiation effects*; D018288:Carcinoma, Small Cell / Q000628:therapy; D003704:Dementia / Q000209:etiology*; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000628:therapy; D008297:Male; D011581:Psychological Tests; D013997:Time Factors
chemical_list: D007370:Interferon Type I