Cytoprotective action of carbenoxolone sodium on ethanol-induced gastric lesions in rats and its inhibition by indomethacin.
Carbenoxolone produced a marked and dose-related inhibition of ethanol-induced gastric lesions in rats. This cytoprotective action was inhibited progressively and significantly by increasing doses of indomethacin. The evidence presented confirms previous suggestions that prostaglandin(s) are involved in the cytoprotective action of carbenoxolone.
Wan
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Gottfried
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D000818:Animals; D002229:Carbenoxolone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000431:Ethanol / Q000633:toxicity*; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000431:Ethanol; D002229:Carbenoxolone; D006034:Glycyrrhetinic Acid; D007213:Indomethacin