title: Calcium, calcium channel blockade and airways function.
abstract: This review will highlight recent advances in understanding the physiological role of calcium and effects of calcium channel blockers on pathogenetic factors in asthma, including airway smooth muscle contraction, mast cell degranulation and mucus secretion. A review of clinical studies with calcium channel blockers in asthma will also be presented.
authors.forename: C G
authors.initials: CG
authors.lastname: Löfdahl
authors.forename: P J
authors.initials: PJ
authors.lastname: Barnes
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000485:Allergens / Q000008:administration & dosage; D000787:Angina Pectoris / Q000150:complications / Q000188:drug therapy; D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects / Q000503:physiopathology; D002118:Calcium / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003080:Cold Temperature; D004347:Drug Interactions; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D066298:In Vitro Techniques; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000494:pharmacology; D009093:Mucus / Q000378:metabolism; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D005082:Physical Exertion; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000187:drug effects*
chemical_list: D000318:Adrenergic beta-Agonists; D000485:Allergens; D002121:Calcium Channel Blockers; D008688:Methacholine Compounds; D016210:Methacholine Chloride; D006632:Histamine; D002118:Calcium