Inhibition of quantal transmitter release by the polycationic ligand cationized ferritin.
Cationized ferritin (200 micrograms ml-1) causes a reduction in both spontaneous and evoked transmitter release at the frog neuromuscular junction. The reduction in EPP amplitude probably reflects reduced Ca2+ -influx since full recovery can be achieved by elevation of [Ca2+]o. The effect on MEPP frequency is independent of [Ca2+]o and may well reflect a direct effect on exocytosis.
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D000818:Animals; D002118:Calcium / Q000378:metabolism; D004594:Electrophysiology; D005293:Ferritins / Q000494:pharmacology*; D008024:Ligands; D008854:Microscopy, Electron; D009045:Motor Endplate / Q000187:drug effects / Q000502:physiology; D009411:Nerve Endings / Q000648:ultrastructure; D009433:Neural Inhibition; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011896:Rana temporaria; D013997:Time Factors
D008024:Ligands; D018377:Neurotransmitter Agents; C010297:polycationic ferritin; D005293:Ferritins; D002118:Calcium