title: Effect of an anticalculus dentifrice on lesion progression under pH cycling conditions in vitro.
abstract: The aim of the present study was to examine a sodium fluoride anticalculus dentifrice product containing soluble pyrophosphate for its ability to promote remineralization and/or inhibit demineralization of dental enamel in a pH cycling model in vitro. Enamel crowns with windows were subjected to 14 days of alternating demineralization and remineralization periods at 37 degrees C. Teeth were immersed 5 min daily in one of the test dentifrice systems (1:3 slurry in deionized water) between the demineralization and remineralization cycles. Test dentifrices included (1) sodium fluoride (NaF; 1,100 ppm F)/silica abrasive (Crest) and (2) NaF (1,100 ppm F) with 3.3% soluble pyrophosphate/silica abrasive (Crest Tartar Control). Controls included a placebo dentifrice (silica abrasive) with no added fluoride and a group which received no treatment at all, i.e., demineralization/remineralization only. Overall, both of the NaF dentifrices were very effective in limiting in vitro caries progression and were not significantly different from each other. Inclusion of pyrophosphate in the NaF dentifrice did not affect the net outcome of the cycling demineralization/remineralization processes which is in agreement with recent clinical and in situ studies of these products.
authors.affiliation: Department of Oral Biology, Eastman Dental Center, Rochester, N.Y.
authors.forename: J D
authors.initials: JD
authors.lastname: Featherstone
authors.forename: M
authors.initials: M
authors.lastname: Shariati
authors.forename: S
authors.initials: S
authors.lastname: Brugler
authors.forename: J
authors.initials: J
authors.lastname: Fu
authors.forename: D J
authors.initials: DJ
authors.lastname: White
mesh_terms: D003728:Dental Calculus / Q000517:prevention & control*; D003731:Dental Caries / Q000517:prevention & control*; D003743:Dental Enamel / Q000033:anatomy & histology / Q000187:drug effects; D003747:Dental Enamel Solubility / Q000187:drug effects; D003802:Dentifrices; D011756:Diphosphates / Q000627:therapeutic use*; D006244:Hardness; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012969:Sodium Fluoride / Q000627:therapeutic use*; D014089:Tooth Remineralization
chemical_list: D003802:Dentifrices; D011756:Diphosphates; D012969:Sodium Fluoride; C003319:sodium pyrophosphate