Lack of effect of nizatidine on hepatic drug metabolism in man.
The effect of nizatidine, a new H2-receptor antagonist, on the hepatic metabolism of three probe drugs was studied in normal volunteers. The drugs studied were chlordiazepoxide and theophylline which are metabolized in part by N-demethylation by the hepatic microsomal cytochrome P-450 system and lorazepam which is conjugated to lorazepam glucuronide. A 7 day course of nizatidine did not interfere with the disposition of any of these therapeutic agents in man.
Secor
J W
JW
Speeg
K V
KV
Meredith
C G
CG
Johnson
R F
RF
Snowdy
P
P
Schenker
S
S
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D002110:Caffeine / Q000378:metabolism; D002707:Chlordiazepoxide / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008140:Lorazepam / Q000378:metabolism; D008297:Male; D016567:Nizatidine; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011485:Protein Binding; D013806:Theophylline / Q000378:metabolism; D013844:Thiazoles / Q000494:pharmacology*
D001798:Blood Proteins; D006635:Histamine H2 Antagonists; D004364:Pharmaceutical Preparations; D013844:Thiazoles; D002110:Caffeine; D002707:Chlordiazepoxide; D013806:Theophylline; D008140:Lorazepam; D016567:Nizatidine