Antigen challenge and canine tracheal mucus.
Tracheal mucus hypersecretion was demonstrated in 7 dogs with cutaneous sensitivity to extracts of Ascaris suum when the dogs were exposed to aerosols of the same antigen. There was a correlation between antigen skin sensitivity and the aerosol dose at which hypersecretion first occurred. In addition to hypersecretion, antigen challenge led to significant alterations in mucus viscoelasticity. The dose-response pattern was similar to that seen with methacholine and histamine aerosol administration in dogs employing the same methodology. The antigen-induced hypersecretion was blocked or substantially reduced by pretreatment with atropine, H1-antagonists, and thiazinamium chloride. These observations suggest that mucus hypersecretion associated with A. suum challenge in dogs involves histamine release and proceeds at least in part via a cholinergic mechanism.
King
M
M
El-Azab
J
J
Phillips
D M
DM
Angus
G E
GE
D000336:Aerosols; D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology*; D001200:Ascaris / Q000276:immunology; D001285:Atropine / Q000494:pharmacology; D004285:Dogs; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D009093:Mucus / Q000276:immunology* / Q000378:metabolism; D012867:Skin / Q000276:immunology; D014132:Trachea / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism
D000336:Aerosols; D000941:Antigens; D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D001285:Atropine