Pharmacokinetic and metabolic study of itanoxone in the crab Pachygrapsus marmoratus (Decapoda, Brachyura): comparative study with clofibric acid.
The LD50 of itanoxone injected i.v. in the crab Pachygrapsus marmoratus is 144 mg/kg. Hypolipidemic drug distribution is distinct according to organ and sex. The fixation power of muscle is comparatively low. Ovary radioactivity is higher than in the testicles. Itanoxone storage is large in the hepatopancreas. Metabolism, increasing over time, is not noticeably different according to sex. Two metabolites, chlorobiphenylcarboxylic acid and chlorobiphenylacetic acid, found in crab, are also identified in rat and man. The pharmacokinetic and metabolic study of itanoxone and clofibric acid in the crab shows a difference between the two drugs. Itanoxone metabolism and fixation is higher than clofibric acid.
Lautier
J
J
Chanal
J L
JL
Delhon
A
A
D000818:Animals; D003386:Brachyura / Q000378:metabolism*; D002090:Butyrophenones / Q000378:metabolism* / Q000633:toxicity; D002994:Clofibrate / Q000378:metabolism*; D005260:Female; D006458:Hemolymph / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000378:metabolism* / Q000633:toxicity; D007700:Kinetics; D007928:Lethal Dose 50; D008297:Male; D013058:Mass Spectrometry; D008954:Models, Biological
D002090:Butyrophenones; D000960:Hypolipidemic Agents; C024140:itanoxone; D002994:Clofibrate