Ventricular fluid somatostatin concentration decreases in childhood-onset dystonia.
Somatostatin was measured in CSF from individuals with a variety of neurologic diseases. In ventricular CSF, somatostatin concentration was significantly lower in individuals with childhood-onset dystonia than in individuals with other forms of dystonia or with other disorders. Severity of childhood dystonia correlated with somatostatin concentration, suggesting a progressive dysfunction of somatostatin-containing neurons with increasing disease severity. There were no significant differences in somatostatin concentration in lumbar CSF. Multiple forms of immunoreactive somatostatin were found in a pool of lumbar CSF from normal individuals. Labeled somatostatin administered intra-arterially to rats failed to cross the blood-brain barrier.
Thal
L J
LJ
Sharpless
N S
NS
Rosenbaum
D
D
Davies
P
P
Amin
I M
IM
Waltz
J M
JM
D000293:Adolescent; D000328:Adult; D000368:Aged; D001923:Brain Chemistry; D002648:Child; D004421:Dystonia / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013004:Somatostatin / Q000134:cerebrospinal fluid*
D013004:Somatostatin