High doses of morphine do not change characteristics of the cerebral catecholamine receptors in the rat.
No changes in striatal and mesolimbic dopamine receptor characteristics were found during catalepsy or hyperactivity phase of morphine action in the rat. The cortical alpha 1-adrenoceptors during the hyperactivity phase were also unchanged.
Rokosz-Kozłowska
A
A
Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Antkiewicz-Michaluk
L
L
Vetulani
J
J
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002375:Catalepsy / Q000139:chemically induced / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D008032:Limbic System / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000008:administration & dosage* / Q000633:toxicity; D011224:Prazosin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects* / Q000378:metabolism; D017983:Receptors, Catecholamine; D013134:Spiperone / Q000378:metabolism
D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine; D013134:Spiperone; D009020:Morphine; D011224:Prazosin