[Screening of single doses of nitrates, calcium antagonists and beta-adrenoblockaders in patients with stenocardia of effort by using pharmacodynamic treadmill studies].
Standard single doses of nitrates, Ca-antagonists and beta-adrenoblockers were studied and compared in 37 patients presenting with stable angina pectoris of effort by repeated treadmill tests coupled with ECG monitoring. The use of isosorbide dinitrate (10 mg), nifedipin (20 mg) and propranolol (40 mg) enabled the effective drug to be screened in 86% of patients. Eleven per cent more of patients responded to the raising of the drug dosage. Isosorbide dinitrate was found to be the most effective in 27% of cases, nifedipin in 19%, and propranolol in 11%. The effect of 2 to 3 drugs was similar in 40% of patients. The data obtained during the screening of the most effective drug in 13 patients, performed by two different methods (treadmill pharmacodynamic and pair bicycle ergomentry tests showed a good agreement in the majority of cases).
Metelitsa
V I
VI
Slastnikova
I D
ID
Martsevich
S Iu
SIu
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000008:administration & dosage* / Q000009:adverse effects; D002908:Chronic Disease; D004341:Drug Evaluation; D005080:Exercise Test / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000008:administration & dosage* / Q000009:adverse effects; D005082:Physical Exertion / Q000187:drug effects; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D009566:Nitrates
Skrining razovykh doz nitratov, antagonistov kal'tsiia i beta-adrenoblokatorov u bol'nykh stenokardieĭ napriazheniia s pomoshch'iu farmakodinamicheskikh issledovaniĭ na tredmile.