title: Calcitonin gene-related peptide: potent vasodilator and major product of calcitonin gene.
abstract: In addition to calcitonin and katacalcin, the human calcitonin gene encodes a novel peptide--calcitonin gene-related peptide (CGRP)--a potent vasodilator. A sensitive and specific radioimmunoassay was developed to study plasma levels of CGRP in normal subjects. CGRP circulates at five times the concentration of calcitonin, suggesting that it may be an important physiological regulator of vascular tone and blood flow.
authors.forename: S I
authors.initials: SI
authors.lastname: Girgis
authors.forename: D W
authors.initials: DW
authors.lastname: Macdonald
authors.forename: J C
authors.initials: JC
authors.lastname: Stevenson
authors.forename: P J
authors.initials: PJ
authors.lastname: Bevis
authors.forename: C
authors.initials: C
authors.lastname: Lynch
authors.forename: S J
authors.initials: SJ
authors.lastname: Wimalawansa
authors.forename: C H
authors.initials: CH
authors.lastname: Self
authors.forename: H R
authors.initials: HR
authors.lastname: Morris
authors.forename: I
authors.initials: I
authors.lastname: MacIntyre
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood* / Q000502:physiology; D051381:Rats; D014664:Vasodilation
chemical_list: D009419:Nerve Tissue Proteins; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide