title: Differential regulation of the two genes encoding Saccharomyces cerevisiae cytochrome c oxidase subunit V by heme and the HAP2 and REO1 genes.
abstract: In Saccharomyces cerevisiae, the COX5a and COX5b genes encode two forms of cytochrome c oxidase subunit V, Va and Vb. We report here that heme increases COX5a expression and decreases COX5b expression and that the HAP2 and REO1 genes are involved in positive regulation of COX5a and negative regulation of COX5b, respectively. Heme regulation of COX5a and COX5b may dictate which subunit V isoform is available for assembly into cytochrome c oxidase under conditions of high- and low-oxygen tension.
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309.
authors.forename: C E
authors.initials: CE
authors.lastname: Trueblood
authors.forename: R M
authors.initials: RM
authors.lastname: Wright
authors.forename: R O
authors.initials: RO
authors.lastname: Poyton
mesh_terms: D015152:Blotting, Northern; D003576:Electron Transport Complex IV / Q000235:genetics*; D005786:Gene Expression Regulation; D005800:Genes, Fungal; D006418:Heme / Q000502:physiology*; D010100:Oxygen / Q000494:pharmacology; D012333:RNA, Messenger / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger; D006418:Heme; D003576:Electron Transport Complex IV; D010100:Oxygen