[Ferrocene, ruthenocene and rhodocene analogs in haloperidol synthesis and organ distribution after labeling with 103Ru and 103mRh].
Ferrocene-Haloperidol was synthesized by N-alkylation of 4-(4'-chlorophenyl)- 4-hydroxypiperidine with 1-ferrocenyl-4-chlor-butan-1-on. By heating the ferrocene-haloperidol with 103RuCl3 the 103Ru-labelled ruthenocene-haloperidol was obtained. This compound showed a high affinity for lung but not for brain in rats and mice. The decay of the 103Ru labelled compound results in the formation of the 103mRh labelled rhodocene-haloperidol, which is rapidly oxidized by air to the corresponding rhodocinium-haloperidol. This compound can be separated by extraction and TLC.
Wenzel
M
M
Pharmazeutisches Institut, Freie Universität Berlin, Berlin-Dahlem, Deutschland.
Wu
Y
Y
D000818:Animals; D001921:Brain / Q000378:metabolism; D005296:Ferrous Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics; D006220:Haloperidol / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D008168:Lung / Q000378:metabolism; D000075163:Metallocenes; D051379:Mice; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051381:Rats; D012238:Rhodium; D012429:Ruthenium Radioisotopes
D005296:Ferrous Compounds; D000075163:Metallocenes; D009942:Organometallic Compounds; D012429:Ruthenium Radioisotopes; C058466:rhodocene; C016721:ruthenocene; D012238:Rhodium; D006220:Haloperidol; C004998:ferrocene
Ferrocen-, Ruthenocen-bzw. Rhodocen-Analoga von Haloperidol Synthese und Organverteilung nach Markierung mit 103Ru-bzw. 103mRh.