Clorazepate in the treatment of complex partial seizures with psychic symptomatology.
Clorazepate frequently can control symptoms in complex partial seizure disorders with psychic symptomatology at dosages less than those recommended for its use as an adjunctive anticonvulsant. Four case examples illustrate this use. These beneficial effects may reflect a heightened response by limbic seizure foci to the anticonvulsant effects of nordiazepam, or a potentiation of its anticonvulsant effects through attenuating patient anxiety.
Griffith
J L
JL
Murray
G B
GB
D000328:Adult; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use; D001007:Anxiety / Q000187:drug effects; D003009:Clorazepate Dipotassium / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003702:Delusions / Q000188:drug therapy / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006212:Hallucinations / Q000188:drug therapy / Q000523:psychology; D006801:Humans; D008032:Limbic System / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D010259:Paranoid Disorders / Q000188:drug therapy / Q000523:psychology
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D003009:Clorazepate Dipotassium