Comparative activity of memory-modulating neuropeptides before and after electric shock in white rats.
Neuropeptides are shown to exert a powerful influence on mnestic processes. They actively eliminate phenomena of electric-shock amnesia, the strongest agent here being arginine vasopressin, while derivatives of oxytocin, enkephalin, and melanostatin are active to a lesser degree. The selective effect on primary learning (ACTH4-7 and Leu-enkephalin) and on the consolidation and restoration of memory (vasopressin and oxytocin), and the presence of only antiamnestic properties (analog of the melanocyte-inhibiting factor) - all this suggests different mechanisms of action of these agents. Memory modulators act more strongly upon activated systems that are already prepared to receive the signal. A promising object for future study as a therapeutic antiamnestic factor is the long-term memory modulator arginine vasopressin.
Medvedev
V I
VI
Bakharev
V D
VD
Kaurov
O A
OA
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000647:Amnesia / Q000188:drug therapy*; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D004743:Enkephalin, Leucine / Q000494:pharmacology; D006801:Humans; D009075:MSH Release-Inhibiting Hormone / Q000031:analogs & derivatives / Q000494:pharmacology; D008568:Memory / Q000187:drug effects*; D010121:Oxytocin / Q000031:analogs & derivatives / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats
D010446:Peptide Fragments; D010455:Peptides; D001127:Arginine Vasopressin; C046432:carbobenzoxyprolyl-leucyl-glycinamide; C038414:oxytocin, des-GlyNH2(9)-; D010121:Oxytocin; C029578:ACTH (4-7); D004743:Enkephalin, Leucine; C046433:oxytocin, Sar(7)-; D000324:Adrenocorticotropic Hormone; D009075:MSH Release-Inhibiting Hormone