Spider toxin (JSTX) blocks glutamate synapse in hippocampal pyramidal neurons.
Effects of spider toxin (JSTX)--a specific blocker of glutamate receptors--on single pyramidal neurons of the hippocampus were studied using tissue slices in vitro. JSTX blocked the synaptic response in CA1 pyramidal cells evoked by Schaffer collateral stimulation without affecting the antidromic spike potential. The toxin suppressed glutamate-induced cell firings whereas it had little effect on aspartate-induced responses. The results suggest that glutamate is a neurotransmitter of the Schaffer collateral input to CA1 pyramidal neurons.
Saito
M
M
Kawai
N
N
Miwa
A
A
Pan-Hou
H
H
Yoshioka
M
M
D000818:Animals; D001180:Arthropod Venoms / Q000494:pharmacology*; D003864:Depression, Chemical; D005971:Glutamates / Q000502:physiology; D018698:Glutamic Acid; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D018091:Receptors, AMPA; D011955:Receptors, Drug / Q000187:drug effects; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D013111:Spider Venoms / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects
D001180:Arthropod Venoms; D005971:Glutamates; C044936:JSTX spider toxin; D018091:Receptors, AMPA; D011955:Receptors, Drug; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D013111:Spider Venoms; D018698:Glutamic Acid