title: A minimum structured adenine nucleotide for ADP/ATP transport in mitochondria.
abstract: An ADP analogue, i.e. 3H- or 14C-labeled 5'-diphosphate of 6-(beta-D-ribofuranosyl-methyl)-4-pyrimidinamine, was synthesized, the structure of which was deduced from structure-activity studies on the substrate specificity of the nucleotide-binding center of the inner mitochondrial membrane integrated ADP/ATP carrier protein. Bearing only the minimal but substrate-essential recognition structures, minimum structured ADP (msADP) is bound to the cytosol-facing active center and transported by the highly specific carrier system across the inner mitochondrial membrane.
authors.affiliation: Institut für Chemie und Physik, Bundesanstalt für Milchforschung, Kiel.
authors.forename: E
authors.initials: E
authors.lastname: Schlimme
authors.forename: K S
authors.initials: KS
authors.lastname: Boos
authors.forename: H
authors.initials: H
authors.lastname: Renz
mesh_terms: D000244:Adenosine Diphosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D000818:Animals; D002250:Carbon Radioisotopes; D007202:Indicators and Reagents; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D000226:Mitochondrial ADP, ATP Translocases / Q000378:metabolism*; D009713:Nucleotidyltransferases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013379:Substrate Specificity; D014316:Tritium
chemical_list: D002250:Carbon Radioisotopes; D007202:Indicators and Reagents; D014316:Tritium; C059220:6-(ribofuranosylmethyl)-4-pyrimidinamine-5'-diphosphate; D000244:Adenosine Diphosphate; D000226:Mitochondrial ADP, ATP Translocases; D009713:Nucleotidyltransferases