title: Treatment with beta-adrenoceptor blockers reduces plasma melatonin concentration.
abstract: In treated hypertensive patients plasma melatonin levels were lower in subjects receiving beta-adrenoceptor blockers than those treated with diuretics. Melatonin concentrations in middle-aged and young control subjects were similar to each other and to those of the diuretic-treated patients. The results suggest that treatment with beta-adrenoceptor blockers causes a persistent reduction in plasma melatonin but it is unclear if this finding has clinical implications.
authors.forename: P J
authors.initials: PJ
authors.lastname: Cowen
authors.forename: J S
authors.initials: JS
authors.lastname: Bevan
authors.forename: B
authors.initials: B
authors.lastname: Gosden
authors.forename: S A
authors.initials: SA
authors.lastname: Elliott
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000367:Age Factors; D000368:Aged; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008550:Melatonin / Q000097:blood*; D008875:Middle Aged
chemical_list: D000319:Adrenergic beta-Antagonists; D004232:Diuretics; D008550:Melatonin