title: Retinal neurotransmission.
abstract: The mammalian retina is classically divided into ten layers which contain the neuronal elements identified as photoreceptors, horizontal cells, bipolar cells, amacrine cells and ganglion cells. Using various neuroscientific techniques possible neurotransmitter substances have been assigned to each of these cell types. Thus the localization of transmitter synthesizing enzymes and storage vesicles, the demonstration of release of transmitter in response to specific stimuli, the observation of post-synaptic events mimicked or blocked by the iontophoretic application of exogenous transmitter/agonist or antagonist drug respectively, and the identification of efficient transmitter inactivation mechanisms synaptically add evidence for the association of certain proposed transmitter substances with specific neuronal elements. The evidence for the proposal that the excitatory amino acids glutamate and aspartate are transmitters of photoreceptors, that gamma-aminobutyric acid (GABA) is the inhibitory transmitter of horizontal and amacrine cells, that acetylcholine is associated with the functioning of bipolar cells, and that taurine, glycine and dopamine may all also play neurotransmitter or neuromodulatory roles at amacrine cell synapses is discussed.
authors.forename: C J
authors.initials: CJ
authors.lastname: Pycock
mesh_terms: D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001224:Aspartic Acid / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D005971:Glutamates / Q000502:physiology; D018698:Glutamic Acid; D005998:Glycine / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology*; D009900:Optic Nerve / Q000502:physiology; D010455:Peptides / Q000502:physiology; D010786:Photoreceptor Cells / Q000502:physiology; D012160:Retina / Q000502:physiology*; D009435:Synaptic Transmission; D013654:Taurine / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D005971:Glutamates; D018377:Neurotransmitter Agents; D010455:Peptides; D013654:Taurine; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine; D005998:Glycine; D004298:Dopamine