[Smooth muscle cells express in culture a surface antigen identified by a polyclonal anti-actin antibody].
These results demonstrate the presence of actin on the surface of smooth muscle cells in culture. The expression of surface actin is modified by drugs (calcium, ionophore A 23187, LTB4) involved in cell metabolism. Actin exists also in intracellular cytoskeleton and extracellular matrix and is a smooth muscle differentiation marker that may be related to adhesion and cell locomotion.
Desmoulière
A
A
INSERM, Unité 8 de Cardiologie, Pessac.
Lamazière
J M
JM
Larrue
J
J
D000199:Actins / Q000032:analysis*; D000818:Animals; D000954:Antigens, Surface / Q000032:analysis*; D001013:Aorta, Thoracic; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002478:Cells, Cultured; D003593:Cytoplasm / Q000032:analysis; D005455:Fluorescent Antibody Technique; D007975:Leukotriene B4 / Q000494:pharmacology; D008252:Macaca fascicularis; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000187:drug effects / Q000276:immunology
D000199:Actins; D000954:Antigens, Surface; D007975:Leukotriene B4; D000001:Calcimycin; D002118:Calcium
Les cellules musculaires lisses expriment en culture un antigène de surface reconnu par un anticorps polyclonal anti-actine.