title: Adult T-cell leukemia in two siblings. Acute crisis of smoldering disease in one patient.
abstract: Two cases of human T-cell leukemia virus (HTLV)-positive adult T-cell leukemia (ATL) in brother and sister are presented. Six of 15 members of this family were seropositive for antibodies for ATL-associated antigens (ATLA). The sister of the ATL patient developed overt ATL after 5 years and 8 months of smoldering ATL. Immunologic examinations during the smoldering phase were normal except for negative skin tests for purified protein derivative. Factors leading to the induction of ATL among HTLV carriers remain to be studied.
authors.forename: H
authors.initials: H
authors.lastname: Taguchi
authors.forename: K
authors.initials: K
authors.lastname: Niiya
authors.forename: I
authors.initials: I
authors.lastname: Kubonishi
authors.forename: S
authors.initials: S
authors.lastname: Yano
authors.forename: S
authors.initials: S
authors.lastname: Yoshimoto
authors.forename: M
authors.initials: M
authors.lastname: Fujishita
authors.forename: T
authors.initials: T
authors.lastname: Kitagawa
authors.forename: M
authors.initials: M
authors.lastname: Mitani
authors.forename: I
authors.initials: I
authors.lastname: Miyoshi
mesh_terms: D000208:Acute Disease; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002353:Carrier State; D015480:Deltaretrovirus Antibodies; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012192:Retroviridae Infections / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D000914:Antibodies, Viral; D000970:Antineoplastic Agents; D015480:Deltaretrovirus Antibodies