1,2-Dibromoethane initiation of hepatic nodules in Sprague-Dawley rats selected with Solt-Farber system.
Initiating effects of the fumigant 1,2-dibromoethane (DBE) for liver were examined using the Solt-Farber selection system. Male Sprague Dawley rats (230-260 g) were given one oral dose of DBE (75 mg/kg), a two-thirds partial hepatectomy 4 h later, five oral doses of 2-acetylamidofluorene (AAF) (25 mg/kg) on days 17-21, CCl4 (2 ml/kg) on day 22, a booster dose of AAF (10 mg/kg) on day 32, and were sacrificed on day 82. Nodules and appreciable gamma-glutamyl transpeptidase foci were found in the livers of four of six animals given DBE, but not in any animals of the control group.
Moslen
M T
MT
Ahluwalia
M B
MB
Farber
E
E
D015073:2-Acetylaminofluorene / Q000633:toxicity; D000284:Administration, Oral; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury; D015946:Ethylene Dibromide / Q000633:toxicity*; D006842:Hydrocarbons, Brominated / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008107:Liver Diseases / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D006842:Hydrocarbons, Brominated; D015946:Ethylene Dibromide; D015073:2-Acetylaminofluorene; D002251:Carbon Tetrachloride; D005723:gamma-Glutamyltransferase