[Comparison of the effect of linolenic acid and eicosapentaenoic acid on prostaglandin biosynthesis and thrombocyte function in humans].
Platelet aggregation, bleeding time, prostaglandin biosynthesis and plasma cholesterol fatty acids were investigated in 12 healthy females (25-32 years), who were given different amounts of linolenic acid (0%, 4%, 8%, 12%, 16% of total energy intake) or eicosapentaenoic acid (1.7%) with formula diets for 2 weeks each. Linolenic and eicosapentaenoic acids prolonged the bleeding time and inhibited platelet aggregation and prostaglandin biosynthesis. These effects became apparent after a linolenic acid intake of 12% of the energy intake. A decrease in PGE in 24 h urine was observed after intake of linolenic acid amounting to 8% of energy intake. Eicosapentaenoic acid influenced all parameters measured ten times more than linolenic acid. Linolenic acid intake had no effect on the ratio of linoleic/arachidonic acids in plasma cholesterol esters in contrast to in vitro findings. Thus energy intake comprising 1.7% of eicosapentaenoic acid is sufficient to affect thrombocyte function in man. The concomitant intake of linolenic-type fatty acids inhibits the biosynthesis of prostaglandins E2 and F2 alpha to different degrees.
Adam
O
O
Wolfram
G
G
Zöllner
N
N
D000328:Adult; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects*; D002788:Cholesterol Esters / Q000097:blood; D015237:Dinoprost; D015232:Dinoprostone; D004305:Dose-Response Relationship, Drug; D015118:Eicosapentaenoic Acid / Q000494:pharmacology*; D005260:Female; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000097:blood; D008042:Linolenic Acids / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011458:Prostaglandins E / Q000652:urine*; D011460:Prostaglandins F / Q000652:urine*; D014914:Whole Blood Coagulation Time; D017962:alpha-Linolenic Acid
D001095:Arachidonic Acids; D002788:Cholesterol Esters; D008041:Linoleic Acids; D008042:Linolenic Acids; D011458:Prostaglandins E; D011460:Prostaglandins F; D017962:alpha-Linolenic Acid; D016718:Arachidonic Acid; D019787:Linoleic Acid; D015118:Eicosapentaenoic Acid; D015237:Dinoprost; D015232:Dinoprostone
Vergleich der Wirkung von Linolensäure und Eicosapentaensäure auf die Prostaglandinbiosynthese und Thrombozytenfunktion beim Menschen.