A comparative study of the effect of three doses of nedocromil sodium and placebo given by pressurized aerosol to asthmatics with exercise-induced bronchoconstriction.
The effect of placebo and 1 mg, 4 mg, or 8 mg nedocromil sodium, administered 60 minutes prior to treadmill challenge, was determined in a double-blind study of 12 adult asthmatics with reproducible exercise-induced bronchoconstriction. All nedocromil sodium treatments gave significantly smaller falls in PEFR than placebo. Four and 8 mg gave significantly greater protection than 1 mg.
Vilsvik
J
J
Lung Department, Regional Hospital, University of Trondheim, Norway.
Schaanning
J
J
D000328:Adult; D000336:Aerosols; D001249:Asthma / Q000517:prevention & control*; D001250:Asthma, Exercise-Induced / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007258:Informed Consent; D017835:Nedocromil; D010919:Placebos; D015363:Quinolones / Q000008:administration & dosage*
D000336:Aerosols; D010919:Placebos; D015363:Quinolones; D017835:Nedocromil