Somatostatin-like immunoreactivity and somatostatin receptor binding in rat brain before and after pentylenetetrazol-induced convulsion.
Wistar rats were injected with a convulsant doze of pentylenetetrazol (PTZ) (50 mg/kg, i.p.). Somatostatin-like immunoreactivity (SLI) and 125I-Tyr11-somatostatin binding were measured in various brain areas immediately after PTZ injection, after the first head twitches, and 15 minutes, 1 h, 4 h, and 24 h after generalized tonic-clonic convulsions. SLI tended to decrease in the striatum (p less than 0.02), frontal cortex, hippocampus, and hypothalamus 1 hour after convulsion. Specific somatostatin binding remained stable. According to our results, somatostatin is not connected to initiation or spread of seizure but may play some role in depressing seizures.
Pitkänen
A
A
Sirviö
J
J
Jolkkonen
J
J
Riekkinen
P
P
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005625:Frontal Lobe / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017481:Receptors, Somatostatin; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*; D013004:Somatostatin / Q000032:analysis*
D011956:Receptors, Cell Surface; D017481:Receptors, Somatostatin; D013004:Somatostatin; D010433:Pentylenetetrazole