Somatostatin and water excretion in man: an intrarenal action.
Intravenous infusion of somatostatin in six water loaded normal human subjects produced a prompt reduction in urine flow accompanied by a rise in urine osmolality and a decrease in free water clearance. Plasma AVP levels did not change. Somatostatin would seem to exert an antidiuretic effect directly on the kidney.
Walker
B J
BJ
Evans
P A
PA
Forsling
M L
ML
Nelstrop
G A
GA
D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008297:Male; D009994:Osmolar Concentration; D013004:Somatostatin / Q000494:pharmacology*; D014554:Urination / Q000187:drug effects; D014867:Water / Q000378:metabolism*
D014867:Water; D001127:Arginine Vasopressin; D013004:Somatostatin