Hormonal responsiveness of liver cells during the liver regeneration process induced by carbon tetrachloride administration.
In control rats most of the ureagenic effect of adrenaline is mediated through alpha1-adrenoceptors with little participation of beta-adrenoceptors. Administration of carbon tetrachloride to rats induces significant changes in the adrenergic responsiveness of their hepatocytes. In rats intoxicated 3-5 days before the experiments were performed there is a marked increase in the beta-adrenergic and a decrease in the alpha-adrenergic responsiveness of the hepatocytes. The alpha1-adrenergic responsiveness increased with time reaching its basal level 15 days after the administration of carbon tetrachloride; simultaneously, the betal-adrenergic responsiveness was decreased. No change in the responsiveness to vasopressin and angiotensin II was observed in intoxicated animals as compared to the controls. In contrast, the responsiveness to glucagon was increased. Increased ability of local anesthetics to decrease urea production was observed in cells from intoxicated animals. It is suggested that changes at the plasma membrane level (lipids, receptors and transducing proteins) might participate in producing these effects.
García-Sáinz
J A
JA
Nájera-Alvarado
A
A
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology; D002724:Chlorobutanol / Q000494:pharmacology; D000242:Cyclic AMP / Q000096:biosynthesis; D005260:Female; D005934:Glucagon / Q000494:pharmacology; D008115:Liver Regeneration / Q000187:drug effects; D008563:Membrane Lipids / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013748:Tetracaine / Q000494:pharmacology; D013997:Time Factors; D014508:Urea / Q000096:biosynthesis; D014667:Vasopressins / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D008563:Membrane Lipids; D010743:Phospholipids; D013748:Tetracaine; D014667:Vasopressins; D000804:Angiotensin II; D014508:Urea; D005934:Glucagon; D011433:Propranolol; D002251:Carbon Tetrachloride; D000242:Cyclic AMP; D002724:Chlorobutanol