title: [Change in skin reactivity in anaphylaxis to muscle relaxants and hypnotics after administration of anti H1, anti H2 and tritoqualine].
abstract: Inhibition of allergic skin reactivity was studied by the technique of thresholds in 35 patients presenting with an anaphylaxis to muscle relaxants. This method was useful to determine the anti-histamine or anti-anaphylactic effects of different substances. The best results were obtained with hydroxyzine. Associating it with an anti H2 drug (cimetidine or ranitidine) did not improve these results. Skin reactivity was never entirely abolished. This confirmed that no premedication could avoid the occurrence of an anaphylactic shock, or even reduce its magnitude. However, premedicating before general anaesthesia with anti H1 and anxiolytic drugs must be continued for all high risk patients: the prevention of non-specific histamine release appeared to be much more efficient than that of anaphylaxis.
authors.forename: D A
authors.initials: DA
authors.lastname: Moneret-Vautrin
authors.forename: M C
authors.initials: MC
authors.lastname: Laxenaire
authors.forename: C
authors.initials: C
authors.lastname: Mouton
authors.forename: S
authors.initials: S
authors.lastname: Widmer
authors.forename: P
authors.initials: P
authors.lastname: Pupil
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced / Q000517:prevention & control*; D003875:Drug Eruptions / Q000209:etiology / Q000517:prevention & control*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D007546:Isoquinolines / Q000008:administration & dosage; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects*; D011229:Preanesthetic Medication / Q000379:methods; D012306:Risk; D012882:Skin Tests; D013390:Succinylcholine / Q000009:adverse effects*
chemical_list: D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D006993:Hypnotics and Sedatives; D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; C003722:tritoqualine; D013390:Succinylcholine
vernacular_title: Modification de la réactivité cutanée dans l'anaphylaxie aux myorelaxants et hypnotiques après administration d'anti H1, d'anti H2 et de tritoqualine.