[Modulation of brain Ca2+-calmodulin-dependent phosphodiesterase activity by naphthalene sulfamides].
Several W-7 analogs were synthesized. These compounds were shown to inhibit the calmodulin-activated phosphodiesterase. A comparative analysis of kinetic parameters of W-7 and its analogs was carried out. A hypothetical model of the effects of calmodulin inhibitors is proposed.
Shaĭkhin
S M
SM
Muratova
M V
MV
Belov
A A
AA
Khropov
Iu V
IuV
Kulagin
S V
SV
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D007700:Kinetics; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013424:Sulfanilamides / Q000138:chemical synthesis* / Q000494:pharmacology; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology
D002147:Calmodulin; D009281:Naphthalenes; D013424:Sulfanilamides; D013449:Sulfonamides; C017967:W 7; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases
Moduliatsiia fermentativnoĭ aktivnosti Ca2+-kalmodulin-zavisimoĭ fosfodiésterazy iz mozga soedineniiami naftalinsul'famidnogo riada.