Influence of ethanol upon the introduction of tyrosine aminotransferase in liver, upon the NAD content in liver and brain, and upon the activity of glutamate oxalate aminotransferase and glutamate pyruvate aminotransferase in the serum of rats.
The influence of ethanol, tryptophan, nicotinamide and methionine upon the activity of glutamate oxalate aminotransferase and glutamate pyruvate aminotransferase in serum as well as the induction of tyrosine aminotransferase in the liver, and of NAD+ + NADH in liver and brain are described. After oral application of 6 g/kg ethanol, the activities of the examined enzymes and the concentrations of NAD+ + NADH in the brain as well as in the liver did not change over a period of 8 hr. Administration of L-methionine lead--as is the case with DL-tryptophan--to a decrease of the NAD+ + NADH-concentration in the brain. A simultaneous application of nicotinamide, DL-tryptophan, L-methionine of l-methylnicotinamide together with ethanol caused a significant increase of the tyrosine aminotransferase induction in adrenalectomized animals. Ethanol reduced the activity of the ADPR transferase in the nuclei of rat liver cells.
Kröger
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H
Grätz
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R
Grahn
H
H
D000315:Adrenalectomy; D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D001923:Brain Chemistry / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008715:Methionine / Q000378:metabolism / Q000494:pharmacology; D009243:NAD / Q000378:metabolism*; D009536:Niacinamide / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014364:Tryptophan / Q000494:pharmacology; D014444:Tyrosine Transaminase / Q000378:metabolism*
D009243:NAD; D009536:Niacinamide; D000431:Ethanol; D014364:Tryptophan; D008715:Methionine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D014444:Tyrosine Transaminase; C024058:N(1)-methylnicotinamide