[Changes in acetylcholine contractions induced by carnitine in coronary vessels isolated "in vitro"].
As suggested by literature about the carnitine's choline-mimetic effects, it has been studied the influence of this substance on the response to Ach of the isolated coronary arteries. It has been seen that Ach has often induced the contraction of the preparation that was preceded or abolished by atropine or prifinium bromide, or reduced by fendiline and verapamil. It resulted also that carnitine has always increased the entity of the contraction of the preparation treated with Ach and that the raising was abolished by fendiline or verapamil. Taking such results and suggestions from the literature as a basis, it has been concluded that the carnitine increased the response of the preparation to Ach, sensitizing muscarinic receptors which cause the entry of Ca++ throught the cell membrane.
Bettini
V
V
Catozzo
C
C
Martino
R
R
Mayellaro
F
F
Munari
L
L
Tegazzin
V
V
Ton
P
P
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002331:Carnitine / Q000494:pharmacology*; D002417:Cattle; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology*; D005275:Fendiline / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D009119:Muscle Contraction / Q000187:drug effects; D011759:Pyrrolidines / Q000494:pharmacology; D011976:Receptors, Muscarinic / Q000502:physiology; D014700:Verapamil / Q000494:pharmacology
D011759:Pyrrolidines; D011976:Receptors, Muscarinic; D001285:Atropine; D014700:Verapamil; D000109:Acetylcholine; D005275:Fendiline; D002331:Carnitine; D002118:Calcium
Modificazioni della contrazione da acetilcolina indotte dalla carnitina su vasi coronarici isolati "in vitro".