title: Pharmacological actions of ifenprodil in the rat isolated anococcygeus muscle.
abstract: The effect of ifenprodil on the contractile responses of the rat anococcygeus muscle to noradrenaline, methoxamine, carbachol, potassium chloride and calcium chloride has been examined. Ifenprodil (10(-8)-10(-7) M) non-competitively antagonized noradrenaline and methoxamine-induced contractions while carbachol-induced responses were unaffected. Similarly, contractile responses to KCl (in tissues from reserpinized animals, or tissues bathed in Tyrode containing 10(-6) M phentolamine) and CaCl2 in tissues bathed with Ca2+-free depolarizing solution were blocked non-competitively by ifenprodil (10(-7)-10(-6) M). These findings suggest that ifenprodil possesses alpha-adrenoceptor antagonist activity, with intrinsic Ca2+ blocking properties.
authors.forename: A S
authors.initials: AS
authors.lastname: Adeagbo
authors.forename: A O
authors.initials: AO
authors.lastname: Magbagbeola
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D002122:Calcium Chloride / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000317:Adrenergic alpha-Antagonists; D010880:Piperidines; D014665:Vasodilator Agents; D011189:Potassium Chloride; D002217:Carbachol; D008729:Methoxamine; D002122:Calcium Chloride; C010739:ifenprodil; D009638:Norepinephrine