title: Sustained pectin ingestion: effect on gastric emptying and glucose tolerance in non-insulin-dependent diabetic patients.
abstract: The effects of sustained pectin ingestion on gastric emptying, glucose tolerance, and hormone responses were studied in 12 stable, non-insulin-dependent (type 2) diabetic patients. Patients were placed on a 2400 kcal, low-fiber (3 g) diet for 2 wk, followed by 4 wk of an isocaloric diet supplemented with 20 g apple pectin/d. Gastric-emptying half-time, plasma glucose, glucagon, and human pancreatic polypeptide levels were determined. Gastric-emptying half-time was prolonged 43% (p less than 0.025) by pectin supplementation and returned to normal 3 d after its discontinuation. Fiber supplementation decreased the incremental area under the glucose tolerance curve from 34.8 +/- 3.0 to 27.9 +/- 3.2 mmol/L (p less than 0.01) but did not affect hormonal responses to a meal. Sustained pectin ingestion slowed the gastric-emptying rate and improved glucose tolerance; however, a direct relationship could not be demonstrated between changes in gastric emptying and changes in the incremental area under the glucose curve (r = 0.22).
authors.affiliation: Department of Medicine and Radiology (Nuclear Medicine), State University of New York, SUNY Health Science Center 13210.
authors.forename: S E
authors.initials: SE
authors.lastname: Schwartz
authors.forename: R A
authors.initials: RA
authors.lastname: Levine
authors.forename: R S
authors.initials: RS
authors.lastname: Weinstock
authors.forename: S
authors.initials: S
authors.lastname: Petokas
authors.forename: C A
authors.initials: CA
authors.lastname: Mills
authors.forename: F D
authors.initials: FD
authors.lastname: Thomas
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy / Q000503:physiopathology*; D004043:Dietary Fiber / Q000008:administration & dosage; D005260:Female; D005527:Food, Fortified; D005746:Gastric Emptying / Q000187:drug effects*; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010368:Pectins / Q000494:pharmacology*
chemical_list: D004043:Dietary Fiber; D010368:Pectins