title: Lymphocyte cell membrane handling of sodium and blood pressure control during salt restriction in normotensive subjects.
abstract: Intralymphocytic sodium and potassium concentrations, 22Na efflux rate constants (EFRC) and blood pressures (BPs) were studied in nine normotensive young males without a history of essential hypertension before, during and after 5 weeks of severe sodium depletion. Diastolic and median BPs decreased significantly as estimated by both ambulatory and home readings. A slight decrease in intralymphocytic potassium content and a significant increase in sodium content was found. Measurements of 22Na-EFRC were reduced by 15% in the ouabain-sensitive component of the sodium pump, while the absolute sodium efflux stayed constant during sodium depletion. These results are evidence of a primary inhibition of the sodium pump during salt restriction in normotensives.
authors.affiliation: Department of Clinical Chemistry, Odense University Hospital, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Jest
authors.forename: K E
authors.initials: KE
authors.lastname: Pedersen
authors.forename: N A
authors.initials: NA
authors.lastname: Klitgaard
authors.forename: A
authors.initials: A
authors.lastname: Arentoft
authors.forename: J R
authors.initials: JR
authors.lastname: Nielsen
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism; D004039:Diet, Sodium-Restricted; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D009318:Natriuresis / Q000502:physiology; D012964:Sodium / Q000097:blood*; D012979:Sodium Radioisotopes; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology
chemical_list: D012979:Sodium Radioisotopes; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase