[Effect of anti-angina agents on the intensity of lipid peroxidation in the myocardium and liver of rats under hyperbaric oxygenation].
It was shown that in the rats exposed to hyperbaric oxygenation, as compared to the animals being under normal atmospheric conditions, nitroglycerin did not increase the level of free radicals (FR) in the myocardium and liver and significantly decreased the amplitude of nitrosyl complexes of iron in the liver. The obsidan-induced changes of FR and final products of lipid peroxidation in the myocardium were prevented. Isoptine was found to increase the contents of FR and final products of lipid peroxidation in the animal liver.
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D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D006321:Heart / Q000187:drug effects*; D006931:Hyperbaric Oxygenation; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D005996:Nitroglycerin / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D013858:Thiobarbiturates / Q000378:metabolism; D014700:Verapamil / Q000494:pharmacology*
D005609:Free Radicals; D013858:Thiobarbiturates; D011433:Propranolol; D014700:Verapamil; D005996:Nitroglycerin; C029684:thiobarbituric acid
Vliianie antianginal'nykh sredstv na intensivnost' perekisnogo okisleniia lipidov v miokarde i pecheni krys pri giperbaricheskoĭ oksigenatsii.