title: Stimulation of aromatase activity in the fetal rat gonads by cAMP and FSH.
abstract: The gonads from 17- to 21-day-old fetal rats were cultured in vitro in the presence of [3H]testosterone and in the presence or absence of cAMP or FSH, and estrone and estradiol formed were measured by double isotopic dilution and recrystallization to constant specific activity. Estrogen synthesis by testes was stimulated by both cAMP and FSH as early as at 18 days of gestation. FSH did not enhance aromatase activity in ovaries, although cAMP did. It is remarkable that FSH controls estrogen synthesis in the testis earlier than in the ovary.
authors.affiliation: Laboratoire de Zoologie et d'Embryologie expérimentale, Université Louis-Pasteur, Strasbourg, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Weniger
authors.forename: A
authors.initials: A
authors.lastname: Zeis
mesh_terms: D000818:Animals; D001141:Aromatase / Q000378:metabolism*; D000242:Cyclic AMP / Q000494:pharmacology*; D004958:Estradiol / Q000096:biosynthesis; D004970:Estrone / Q000096:biosynthesis; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D008297:Male; D009924:Organ Culture Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000196:embryology / Q000201:enzymology*; D013739:Testosterone / Q000494:pharmacology
chemical_list: D004970:Estrone; D013739:Testosterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone; D000242:Cyclic AMP; D001141:Aromatase