[The elimination of disorders in the acquisition of a conditioned active avoidance reaction by using the C-termination fragment of lysyl vasopressin].
In experiments with male white rats it was shown that 0.001 and 0.01 mg/kg of lysyl vasopressin C-terminal fragment--Pro-Lys-Gly (PLG) being injected intraperitoneally fails to influence the acquisition of active and passive avoidance and also T-maze food rewarded behaviour. The injection of PLG removed by disturbances of active avoidance caused by cyproheptadine and oxytocin. The inhibition of passive avoidance and food-rewarded behaviour was not removed by PLG.
Titov
S A
SA
Shamakina
I Iu
IIu
Nikonova
A B
AB
Voskresenskaia
O G
OG
Kalikhevich
V N
VN
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D003533:Cyproheptadine / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology; D004558:Electric Stimulation; D005247:Feeding Behavior / Q000187:drug effects; D006247:Harmine / Q000494:pharmacology; D008236:Lypressin / Q000494:pharmacology*; D008297:Male; D010121:Oxytocin / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
D010446:Peptide Fragments; D003533:Cyproheptadine; D006247:Harmine; D010121:Oxytocin; D008236:Lypressin; D004050:Ditiocarb
Ustranenie narusheniĭ vyrabotki uslovnoĭ reaktsii aktivnogo izbeganiia C-kontsevym fragmentom lizilvazopressina.