title: Metastatic islet cell amphicrine carcinoma of the pancreas. Association with an eosinophilic infiltration of the skin.
abstract: Nodular skin lesions consisting of eosinophilic cell infiltrates developed in a 45-year-old man with metastatic islet cell amphicrine carcinoma of the pancreas. These infiltrates did not fit previously described eosinophilic skin conditions. Although the tumor responded to conventional chemotherapy, the skin lesions did not. They did, however, respond completely to radiation therapy. This clinical constellation has not been reported previously and may represent a new paraneoplastic syndrome.
authors.affiliation: Division of General Internal Medicine, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Hanover, New Hampshire 03756.
authors.forename: W D
authors.initials: WD
authors.lastname: Kniffin
authors.forename: S K
authors.initials: SK
authors.lastname: Spencer
authors.forename: V A
authors.initials: VA
authors.lastname: Memoli
authors.forename: P J
authors.initials: PJ
authors.lastname: LeMarbre
mesh_terms: D007516:Adenoma, Islet Cell / Q000473:pathology* / Q000628:therapy; D004802:Eosinophilia / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000628:therapy; D012867:Skin / Q000473:pathology*