title: Interaction of biologic and psychologic factors in the origin of depressive disorders.
abstract: In reviewing the literature 12 years after the publication of a unified model of depressive illness, the author finds that such a model still provides the most adequate explanation of this illness permitted by current data.
authors.forename: H S
authors.initials: HS
authors.lastname: Akiskal
mesh_terms: D000367:Age Factors; D001921:Brain / Q000201:enzymology; D003866:Depressive Disorder / Q000201:enzymology / Q000209:etiology* / Q000235:genetics / Q000523:psychology; D005260:Female; D005783:Gender Identity; D006801:Humans; D008016:Life Change Events; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D012306:Risk; D012923:Social Class; D012931:Social Environment; D013315:Stress, Psychological / Q000150:complications; D013694:Temperament
chemical_list: D018377:Neurotransmitter Agents; D008995:Monoamine Oxidase