The use of SMS 201-995 (somatostatin analogue) in insulinomas. Additional case report and literature review.
A 76-year-old man, a known case of insulinoma, was well controlled for 11 days on 50 micrograms SMS 201-995 every 12 h; clinical recovery was immediate with normalization of blood sugars and C-peptide levels. The potential value of this new drug in the management of insulinomas is illustrated by this case and by 11 additional case reports which are reviewed. A rise in C-peptide levels during treatment without concomitant hypoglycaemia might be the first indication of a loss of control.
Hearn
P R
PR
Department of Biological and Medical Research, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
Ahmed
M
M
Woodhouse
N J
NJ
D007516:Adenoma, Islet Cell / Q000188:drug therapy*; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D006801:Humans; D007340:Insulinoma / Q000188:drug therapy*; D008297:Male; D015282:Octreotide / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D001786:Blood Glucose; D002096:C-Peptide; D015282:Octreotide