Appearance of collagenase in pneumolysin-treated corneal fibroblast cultures.
Sub-lethal levels of pneumolysin, a cytolytic toxin produced by the pneumococcus, have been shown to increase collagenase concentration in cultures of rabbit corneal fibroblasts. Interactions between pneumolysin and corneal cells may be involved in the pathogenesis of pneumococcal ocular infections.
Johnson
M K
MK
Department of Microbiology and Immunology, Tulane Medical Center, New Orleans, LA.
Gebhardt
B M
BM
Berman
M B
MB
D000818:Animals; D001426:Bacterial Proteins; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003315:Cornea / Q000166:cytology / Q000201:enzymology*; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology*; D003012:Microbial Collagenase / Q000378:metabolism*; D013301:Streptolysins / Q000494:pharmacology*
D001426:Bacterial Proteins; D013301:Streptolysins; C032290:plY protein, Streptococcus pneumoniae; D003012:Microbial Collagenase