[Effect of eicosapentaenoic acid on lipid metabolism in rabbits with experimental atherosclerosis].
Group 1 rabbits received cholesterol (CS) in a dose of 0.5 g/kg/day, per os, during 4, 8 and 12 weeks that resulted in a significant increase of the total CS level in the blood serum of the total lipids (TL), phospholipids and beta-lipoproteins (3-10 times). Combined administration of CS and 40% eicosapentaenoic acid (EPA), 0.6 ml/kg, to group 2 rabbits led to a decrease in the values studied by 20-70%. By the end of the experiment the content of CS and TL in the liver of group 2 rabbits comprised 65-71% of that recorded in group 1 animals. It was also shown that the degree of sclerotic degeneration of the thoracic aorta in group 2 was lower by 55% as compared to group 1 animals. The data obtained have evidenced the hypolipidemic and antiatherosclerotic effect of EPA.
Ren
L Kh
LKh
Vasil'ev
A V
AV
Tutel'ian
V A
VA
D000818:Animals; D001013:Aorta, Thoracic / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D002784:Cholesterol / Q000008:administration & dosage / Q000097:blood; D004353:Drug Evaluation, Preclinical; D015118:Eicosapentaenoic Acid / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D010743:Phospholipids / Q000097:blood; D011817:Rabbits; D013997:Time Factors
D008055:Lipids; D008077:Lipoproteins, LDL; D010743:Phospholipids; D002784:Cholesterol; D015118:Eicosapentaenoic Acid
Vliianie éĭkozapentaenovoĭ kisloty na lipidnyĭ obmen u krolikov pri éksperimental'nom ateroskleroze.