L-Glutamate depolarizes ON-OFF transient type of amacrine cells in the carp retina: an ionophoretic study.
Amacrine cells generating the ON-OFF transient type of photoresponse, which is most frequently encountered, were identified by intracellular recording and staining with a fluorescent dye Lucifer Yellow in the carp (Cyprinus carpio) retina. L-Glutamate applied ionophoretically slowly depolarized the amacrine cells by about 10 mV and reduced their photoresponses during the application. Such changes gradually recovered following the cessation of L-glutamate injection. The results indicate that this amino acid directly activates the ON-OFF type amacrine cells.
Kato
S
S
Teranishi
T
T
Negishi
K
K
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002347:Carps / Q000502:physiology*; D003530:Cyprinidae / Q000502:physiology*; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D009474:Neurons / Q000187:drug effects; D012160:Retina / Q000166:cytology / Q000187:drug effects*; D013268:Stimulation, Chemical
D005971:Glutamates; D018698:Glutamic Acid