Effect of aminoglycoside antibiotics on sodium transport across the Rana esculenta urinary bladder.
The aminoglycoside antibiotics inhibit the short circuit current (s.c.c.) in the urinary bladder of Rana esculenta. This effect is due to a direct inhibition on the sodium pump; ADH or db-AMPc are not able to reverse the inhibition of the sodium current, but are effective in stimulating the urea fluxes in the presence of antibiotics. In correlation with the number of the NH+2 groups in the antibiotic molecule there is a different pattern of inhibitory effect, i.e. neomycin greater than gentamycin greater than dihydrostreptomycin greater than kanamycin greater than spectinomycin.
Micelli
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S
Gallucci
E
E
D000617:Aminoglycosides / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001693:Biological Transport, Active / Q000187:drug effects; D003994:Bucladesine / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D011893:Rana esculenta; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014508:Urea / Q000378:metabolism; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism*; D014667:Vasopressins / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D014667:Vasopressins; D003994:Bucladesine; D014508:Urea; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase