[Epidemiological studies of adult T-cell leukemia virus in patients with adult T-cell leukemia (ATL) and ATL-related diseases in Hokkaido District of Japan].
Sera and peripheral blood lymphocytes in 40 clinical cases of adult T-cell leukemia (ATL) and 66 cases of mature T-cell malignancies in Hokkaido district, the most northern part of Japan, were examined for the infection with ATL virus (ATLV). All of the 40 ATL patients (100%) had antibodies to ATLV-associated antigen (ATLA) and 13 (19.7%) of the 66 patients with mature T-cell malignancies other than ATL were also positive for anti-ATLA. When the peripheral ATL lymphocytes were assessed after short time cultivation, both ATLA antigen and C type virus particles were detectable. In contrast to the high prevalence of ATLV antibodies in these patients, the positivity in 30,000 control individuals in this district was 0.73%. It was calculated that 8 patients of a 40,000 seropositive population are diagnosed annually as ATL in this particular northern part of Japan.
Iwanaga
M
M
Takada
K
K
Fujiwara
S
S
Osato
T
T
Mikuni
C
C
Maekawa
I
I
Miyazaki
T
T
Akahonai
Y
Y
Kwon
K W
KW
Sekiguchi
S
S
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis*; D017977:Deltaretrovirus / Q000276:immunology*; D015480:Deltaretrovirus Antibodies; D005260:Female; D006801:Humans; D007564:Japan; D007938:Leukemia / Q000453:epidemiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012192:Retroviridae Infections / Q000453:epidemiology* / Q000276:immunology
D000914:Antibodies, Viral; D015480:Deltaretrovirus Antibodies