Antihypertensive therapy with diuretics and beta-blockers at fixed dosage: comparison between the combinations labetalol plus chlorthalidone and atenolol plus chlorthalidone.
The aim of this study was a comparison between the hypotensive effects of two fixed combinations (atenolol + chlorthalidone and labetalol + chlorthalidone) in patients suffering from untreated mild to moderate hypertension. Both combinations were effective in reduction of BP values. Heart rate showed no statistically significant modification. The combination of labetalol plus chlorthalidone seems to find its best application in the treatment of mild hypertension.
Roja
M
M
Cumetti
C
C
Vergani
A
A
Montanari
C
C
De Cristofaro
A
A
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D001262:Atenolol / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002752:Chlorthalidone / Q000008:administration & dosage / Q000627:therapeutic use*; D004232:Diuretics / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007741:Labetalol / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male
D000319:Adrenergic beta-Antagonists; D004232:Diuretics; D001262:Atenolol; D002752:Chlorthalidone; D007741:Labetalol