title: Metastasis from uveal melanoma after proton beam irradiation.
abstract: The incidence of metastasis and prognostic factors for metastasis in 780 consecutive patients with uveal melanomas treated with proton beam irradiation were evaluated. Metastasis developed in 64 patients (8%). The median time from treatment to the diagnosis of metastasis was 2.1 years (range, 3 months to 7.3 years). The liver was primarily involved in 58 (90%) patients. The 5-year cumulative probability of metastasis developing was 20%. Prognostic factors for metastasis developing were quite comparable to those found for patients treated by enucleation and included largest tumor diameter, involvement of the ciliary body, older age, and extrascleral extension. Surgical localization, tumor height, and elevated liver enzymes before treatment were not important factors in the development of metastasis.
authors.affiliation: Retina Service, Massachusetts Eye and Ear Infirmary, Boston 02114.
authors.forename: E S
authors.initials: ES
authors.lastname: Gragoudas
authors.forename: J M
authors.initials: JM
authors.lastname: Seddon
authors.forename: K M
authors.initials: KM
authors.lastname: Egan
authors.forename: R J
authors.initials: RJ
authors.lastname: Glynn
authors.forename: M
authors.initials: M
authors.lastname: Goitein
authors.forename: J
authors.initials: J
authors.lastname: Munzenrider
authors.forename: L
authors.initials: L
authors.lastname: Verhey
authors.forename: M
authors.initials: M
authors.lastname: Urie
authors.forename: A
authors.initials: A
authors.lastname: Koehler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary; D008875:Middle Aged; D011522:Protons; D012044:Regression Analysis; D012307:Risk Factors; D013997:Time Factors; D014604:Uveal Neoplasms / Q000532:radiotherapy*
chemical_list: D011522:Protons