[Metastatic characteristics of SY86B human gastric carcinoma in athymic nude mice].
The invasive and metastatic behavior of SY86B human gastric carcinoma in nude mice were further studied. The results showed that this human cancer strain had a relatively high spontaneous metastatic rate (68.4%). The metastasis was related to the invasiveness of the transplanted tumor and tumor-bearing time. Since the metastasis developed from 2nd to 9th passages, it was considered that this model had a stable metastatic tendency. It was observed that the genetic background, age and sex difference of the recipient nude mice may not be associated with the metastasis. Aside from the high transplantable rate (100%) and spontaneous metastatic rate (68.4%), SY86B human gastric carcinoma strain still maintains the morphologic, immunologic, genetic and ultrastructural characteristics of the original tumor. All these make it a useful means in the study of diagnosis and treatment of cancer metastasis.
Li
H
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Cancer Institute, China University of Medical Sciences, Shenyang.
D000818:Animals; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D005260:Female; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000473:pathology*