The effect of muscle movement on the electroencephalogram during anesthesia with alfentanil.
Using aperiodic analysis, we examined the impact on the electroencephalogram (EEG) of muscle activity from opiate-induced rigidity with alfentanil. We compared two groups of patients, one receiving alfentanil with neuromuscular blocking agents and the other group receiving no relaxants. The alfentanil-induced muscle rigidity exerted a noticeable effect on the EEG, with a moderate effect on total power at 1 Hz; a marked effect on the total number of waves, cumulative percent power at 3 Hz, and average power at 17 to 19 Hz; and a striking effect on F90, the frequency below which 90% of the power resides. The presence of electromyographic (EMG) noise in the EEG consistently altered the variables derived from the EEG, so that anesthetic depth appeared less than it actually was. This was true in spite of the fact that we gave slightly more alfentanil in the group not receiving a relaxant. Although the observed muscle activity was greater than that usually seen clinically, and may have differed qualitatively, the results do serve as a warning that muscle noise can interfere with the EEG. Currently, there is no computerized technique that will reject or account for this noise, and we must depend on observation to recognize the EMG patterns within the EEG, either with the raw recording or with a detailed analysis (such as aperiodic analysis), and to compensate for this noise if possible. Techniques that average the EEG or that present a single number have difficulty providing this information. These results do not detract from the usefulness of the EMG contained in EEG recordings as a supplementary or complementary indicator of anesthetic lightness.
Smith
N T
NT
Westover
C J
CJ
Quinn
M
M
Benthuysen
J L
JL
Silver
H D
HD
Sanford
T J
TJ
D015760:Alfentanil; D000701:Analgesics, Opioid; D000771:Anesthesia, Intravenous; D004311:Double-Blind Method; D004569:Electroencephalography / Q000379:methods*; D004576:Electromyography; D005071:Evoked Potentials / Q000187:drug effects; D005283:Fentanyl / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage; D010197:Pancuronium / Q000008:administration & dosage; D011897:Random Allocation; D013390:Succinylcholine / Q000008:administration & dosage; D014403:Tubocurarine / Q000008:administration & dosage / Q000031:analogs & derivatives
D000701:Analgesics, Opioid; D009466:Neuromuscular Blocking Agents; D015760:Alfentanil; D013390:Succinylcholine; D010197:Pancuronium; D005283:Fentanyl; C032943:metocurine; D014403:Tubocurarine