title: Effects of prostaglandin F2 alpha on prolactin secretion in the fowl.
abstract: The plasma concentration of prolactin in immature cockerels was increased between 10 and 40 min after the intravenous administration of prostaglandin (PG) F2 alpha (200 micrograms/kg body weight). Lower doses had no effect on plasma prolactin concentration. The addition of PGF2 alpha (10(-9) to 10(-6) M) to incubation media had no effect on the basal release of pituitary prolactin but reduced the release of prolactin from pituitary-hypothalamus co-incubations. The addition of noradrenaline (10(-7) M), serotonin (10(-7) M), acetylcholine (10(-6) M) or histamine (10(-6) M) to the co-incubation increased the hypothalamus-induced prolactin release, although these effects were not observed in the presence of 10(-7) M PGF2 alpha. The in vitro release of pituitary prolactin was increased by adding chicken hypothalamic extract in the presence or absence of PGF2 alpha. These results suggest a dual effect on PGF2 alpha of prolactin secretion in the fowl; its stimulation in vivo may result from a peripheral action.
authors.forename: T R
authors.initials: TR
authors.lastname: Hall
authors.forename: S
authors.initials: S
authors.lastname: Harvey
authors.forename: A
authors.initials: A
authors.lastname: Chadwick
authors.forename: C G
authors.initials: CG
authors.lastname: Scanes
mesh_terms: D000818:Animals; D002645:Chickens / Q000378:metabolism*; D046508:Culture Techniques; D015237:Dinoprost; D004305:Dose-Response Relationship, Drug; D007031:Hypothalamus / Q000187:drug effects* / Q000502:physiology; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology*; D014020:Tissue Extracts / Q000494:pharmacology
chemical_list: D018377:Neurotransmitter Agents; D011460:Prostaglandins F; D014020:Tissue Extracts; D011388:Prolactin; D015237:Dinoprost