Collagenase-like peptidase activity in serum from patients with rheumatoid arthritis.
The activities of collagenase-like peptidase, estimated by using (succinyl-Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro)-4-methylcoumaryl-7-amide as substrate, and of dipeptidyl-aminopeptidase IV were decreased in the sera from patients with rheumatoid arthritis. Both enzymes bring about the degradation of peptides derived from collagen. A significant positive correlation was observed between the activities of the two serum peptidases.
Iwase-Okada
K
K
Kojima
K
K
Kato
T
T
Kaku
H
H
Okazaki
T
T
Wago
K
K
Sakakibara
S
S
Nagatsu
T
T
D001172:Arthritis, Rheumatoid / Q000097:blood / Q000201:enzymology*; D002561:Cerebrovascular Disorders / Q000097:blood / Q000201:enzymology; D003094:Collagen / Q000378:metabolism; D018819:Dipeptidyl Peptidase 4; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000097:blood; D010450:Endopeptidases / Q000097:blood*; D006801:Humans; D008666:Metalloendopeptidases
D003094:Collagen; D010450:Endopeptidases; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D018819:Dipeptidyl Peptidase 4; D008666:Metalloendopeptidases; C022510:thimet oligopeptidase