On the haemodynamic effects of biogenic amines in isolated fish gills.
The effects of histidine and histamine on branchial vascular haemodynamics were studied using the isolated, perfused gill of the tropical cichlid, Oreochromis (Sarotherodon) niloticus. Histidine had no vasoactive effect while histamine induced vasodilatation. Histamine-induced vasodilatation was irreversibly inhibited by the H1 and H2 receptor antagonists, piriton and cimetidine, respectively. This suggests a possible involvement of the non-neurogenic histaminergic system, acting directly via H1 and H2 histamine receptors, in the regulation of branchial vascular haemodynamics in teleosts.
Okafor
M C
MC
Oduleye
S O
SO
D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology*; D002744:Chlorpheniramine / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D005399:Fishes / Q000502:physiology*; D005880:Gills / Q000098:blood supply*; D006439:Hemodynamics / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques
D001679:Biogenic Amines; D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D002744:Chlorpheniramine; D002927:Cimetidine; D006632:Histamine