[Analysis of an equivalent electric circuit of the hepatocyte during stopping and restoration of the blood flow].
An analysis of an electric scheme of hepatocyte under conditions of stopping and restoring the blood flow taking into account the morphological and biochemical characteristics of the normal and injured liver was carried out. It is shown that the fast phase of restoring the membrane potential (MP) when restoring the blood flow following ischemia is stipulated by restoring extracellular concentrations of potential-generating ions; and slow restoring of the normal liver MP is connected with the phase of potassium efflux hyperpolarization. The injured liver MP stability to ischemia is higher because of the transmembrane ion gradient decrease before ischemia and next effect of depolarisation of passive currents weakening under conditions of closed extracellular space, and total ATPase activity decrease, i.e. a more economical ATP expenditure by the cell at ischemia.
Kabakov
A Iu
AIu
D000818:Animals; D004553:Electric Conductivity; D006801:Humans; D007511:Ischemia / Q000378:metabolism / Q000503:physiopathology*; D008099:Liver / Q000098:blood supply* / Q000201:enzymology / Q000378:metabolism; D008102:Liver Circulation; D008564:Membrane Potentials; D008954:Models, Biological; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology
D000254:Sodium-Potassium-Exchanging ATPase
Analiz ékvivalentnoĭ élektricheskoĭ skhemy gepatotsita v usloviiakh prekrashcheniia i vosstanovleniia krovotoka.