Disposition of 1-[14C]phenyl-1-(3,4-dimethyl) phenylethane, a component of some PCB replacement materials, following intravenous administration to the thorny skate, Raja radiata.
1-[14C]Phenyl-1-(3,4-dimethyl)phenylethane ([14C]PXE), a labelled analogue of a component of some commercial PCB replacement materials, was cleared rapidly from plasma of the thorny skate, Raja radiata, after i.v. injection. A polyexponential fit to the clearance data yielded three linear components with half-lives of 7, 128 and 924 min. The metabolic clearance rate for the mean animal was approximately 41 X kg-1 X d-1. The main storage site for [14C]PXE was the liver, which contained about 40% of the injected dose. Approximately 25% of the injected radioactivity was recovered from the bile within 36 hr of injection in the form of polar metabolites, indicating rapid degradation of [14C]PXE.
Rochefort-Johnson
S M
SM
Willis
D E
DE
Addison
R F
RF
D000818:Animals; D002855:Chromatography, Thin Layer; D005399:Fishes / Q000378:metabolism*; D006207:Half-Life; D007275:Injections, Intravenous; D014018:Tissue Distribution; D014992:Xylenes / Q000008:administration & dosage / Q000378:metabolism*
D014992:Xylenes; C049003:phenyl-1-(3,4-dimethyl)phenylethane