[Effect of almitrine administered by the oral route on levels of 2,3-diphosphoglycerate and on the affinity of hemoglobin for oxygen in healthy subjects].
Clinical and pharmacological studies have shown that almitrine increased arterial blood oxygen partial pressure (PaO2) and tissular oxygenation. We have verified whether this drug could also increase the 2,3 diphosphoglycerate (DPG) level and so modify the oxyhemoglobin dissociation curve (ODC). Determinations performed 3 hours and 5 days after daily oral administration (1,5 mg/kg) of the drug showed no alterations of DPG and ODC in normal subjects. The presence of almitrine does not explain the observed PaO2 increase by means of a direct effect on the hemoglobin oxygen affinity. However, one cannot exclude almitrine long term effect; indeed, after 15 days, DPG levels and Hill coefficient increased significantly (p less than 0.05) but no the P50 (respectively + 1,5 mumole/gHb; +0.1 and 26.0 vs 26.5 mmHg).
Clerbaux
T
T
Frans
A
A
D019794:2,3-Diphosphoglycerate; D000284:Administration, Oral; D000328:Adult; D015765:Almitrine; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000494:pharmacology*; D004163:Diphosphoglyceric Acids / Q000097:blood*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood*; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*
D000697:Central Nervous System Stimulants; D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D010879:Piperazines; D019794:2,3-Diphosphoglycerate; D015765:Almitrine; D010100:Oxygen
Effet de l'almitrine administrée par voie orale sur le taux du diphosphoglycérate (2,3 DPG) et sur l'affinité de l'hémoglobine pour l'oxygène chez le sujet sain.