title: [Side effects of drugs on male fertility].
abstract: Side effects of drugs on male fertility occur more often than they are expected to. In general, they are not recognized till during andrological examination on account of a barren marriage. A transient or permanent inhibition of male fertility by drugs is possible, if one of the following functions interferes: spermatogenesis, sperm maturation within the epididymis, sperm transport, sperm metabolism and motility, semen liquefaction, capacitation, acrosomal reaction, or ovum penetration. Best known is the impairment of spermatogenesis by direct inhibition of the germinal epithelium (antispermatogenic agents: cytostatics, immunosuppressive agents, psychopharmacological compounds, antibiotics) or indirectly by influencing the axis between hypothalamus, pituitary gland, and gonads (hormones: estrogens, gestagens, androgens, anabolics, antiandrogens). Sperm transport may be impaired by neuroleptic drugs, tricyclic antidepressants, antihypertensive drugs like guanethidine, and ganglionic blocking agents. Inhibition of sperm motility is possible by antibiotics, psychopharmacological agents, anthelmintics, and beta receptor blockers. In future, it will therefore be necessary to pay more attention to side effects of drugs on male fertility, particularly with regard to patients at the age of reproductiveness.
authors.forename: W B
authors.initials: WB
authors.lastname: Schill
authors.forename: B
authors.initials: B
authors.lastname: Przybilla
mesh_terms: D045930:Anabolic Agents / Q000009:adverse effects; D000818:Animals; D000935:Antifungal Agents / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D001379:Azathioprine / Q000009:adverse effects; D003078:Colchicine / Q000009:adverse effects; D003606:Dacarbazine / Q000009:adverse effects; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions; D005298:Fertility / Q000187:drug effects*; D005938:Glucocorticoids / Q000009:adverse effects; D012739:Gonadal Steroid Hormones / Q000009:adverse effects; D006634:Histamine H1 Antagonists / Q000009:adverse effects; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects; D012176:Retinoids / Q000009:adverse effects; D013081:Sperm Motility / Q000187:drug effects; D013083:Sperm Transport / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects
chemical_list: D045930:Anabolic Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D005938:Glucocorticoids; D012739:Gonadal Steroid Hormones; D006634:Histamine H1 Antagonists; D012176:Retinoids; D003606:Dacarbazine; D001379:Azathioprine; D003078:Colchicine; D008727:Methotrexate
vernacular_title: Arzneimittel-Nebenwirkungen auf die männliche Fertilität.