Effect of somatostatin on the proliferation of mouse spleen lymphocytes in vitro.
The effect of somatostatin on the spontaneous proliferation of mouse spleen lymphocytes was investigated in vitro. The rate of 3H-thymidine incorporation was used as an index of lymphocyte proliferation. Somatostatin in a concentration of 10(-7) M enhanced the lymphocyte proliferation and abolished the antiproliferative effect of rat hypothalamic extract. Lower concentrations of somatostatin slightly decreased the lymphocyte DNA synthesis.
Pawlikowski
M
M
Stepien
H
H
Kunert-Radek
J
J
Schally
A V
AV
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013004:Somatostatin / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology*; D013936:Thymidine / Q000378:metabolism
D013004:Somatostatin; D013936:Thymidine