title: Non-steroidal anti-inflammatory drugs and renal failure.
abstract: In 3 years seventeen patients presented to one unit with renal failure associated with the use of non-steroidal anti-inflammatory drugs (NSAID). Seven patients presented with acute renal failure, in four due to acute tubular necrosis and in three to acute interstitial nephritis; all recovered when NSAID treatment was stopped. Four patients presented with symptomless renal impairment discovered during routine follow-up in a rheumatology clinic; again all improved on withdrawal of NSAID. The remaining six patients presented with chronic renal failure, a disorder not previously associated with NSAID treatment. The pattern of renal disease associated with NSAID may be more extensive than has previously been recognised. A history of NSAID use should be sought in all patients presenting with unexplained renal failure.
authors.forename: D H
authors.initials: DH
authors.lastname: Adams
authors.forename: A J
authors.initials: AJ
authors.lastname: Howie
authors.forename: J
authors.initials: J
authors.lastname: Michael
authors.forename: B
authors.initials: B
authors.lastname: McConkey
authors.forename: P A
authors.initials: PA
authors.lastname: Bacon
authors.forename: D
authors.initials: D
authors.lastname: Adu
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001032:Apazone / Q000009:adverse effects; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000009:adverse effects; D009395:Nephritis, Interstitial / Q000139:chemically induced; D010894:Piroxicam; D011507:Proteinuria / Q000139:chemically induced; D013843:Thiazines / Q000009:adverse effects
chemical_list: D000893:Anti-Inflammatory Agents; D013843:Thiazines; D010894:Piroxicam; D009288:Naproxen; D003404:Creatinine; D001032:Apazone