title: Immunoregulatory and activated T cells in amyotrophic lateral sclerosis patients.
abstract: Circulatory immune complexes are increased in amyotrophic lateral sclerosis (ALS) and an autoimmune mechanism has been inferred. Autoimmune diseases may have changes in the percentages of immunoregulatory T cells and increased activated T cells (Ia+ T) in peripheral blood. The latter are also increased with active viral and bacterial infection and immunization. We found no significant changes of the percentages of immunoregulatory T cells and no relation of the individual values to the clinical state. Ia+ T cells were not increased over the normal range but within that range there was significant negative correlation with the ALS clinical score.
authors.forename: H
authors.initials: H
authors.lastname: Bartfeld
authors.forename: C
authors.initials: C
authors.lastname: Dham
authors.forename: H
authors.initials: H
authors.lastname: Donnenfeld
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000276:immunology*; D000936:Antigen-Antibody Complex / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000032:analysis* / Q000145:classification
chemical_list: D000936:Antigen-Antibody Complex