The Pgp-1 antigen is expressed on early fetal thymocytes.
The Pgp-1 glycoprotein is expressed on the bone marrow prothymocyte and on a class of intrathymic progenitor cells in the adult animal. Only 5% of adult thymocytes are strongly Pgp-1+. When fetal thymocytes of day 13-14 of gestation are examined by flow cytometric analysis, 80-90% of thymocytes are Pgp-1+, while the bulk of thymocytes are Thy-1-. By day 15-16, the percentage of Pgp-1+ cells begins to fall while nearly all cells become Thy-1+. Two-color immunofluorescence indicates that many Pgp-1+ cells are Thy-1+. The percentage of Pgp-1+ cells continues to fall over the next several days, reaching adult levels by day 19. These observations are consistent with the interpretation that at least some classes of thymocyte progenitors are Pgp-1+.
Lesley
J
J
Trotter
J
J
Hyman
R
R
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000032:analysis*; D002454:Cell Differentiation; D005260:Female; D005434:Flow Cytometry; D005865:Gestational Age; D051379:Mice; D008806:Mice, Inbred AKR; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D018800:Thy-1 Antigens; D013950:Thymus Gland / Q000166:cytology / Q000196:embryology / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D018800:Thy-1 Antigens