title: Distribution and molecular heterogeneity of cholecystokinin-like immunoreactive peptides in the brain and gut of the rainbow trout, Salmo gairdneri.
abstract: Cholecystokinin-like immunoreactivity (CCK-li) was measured in extracts of various brain and gut regions of the rainbow trout, Salmo gairdneri. All regions of the brain except the cerebellum and pituitary contained detectable CCK-li. In the gut, the highest concentrations of CCK-li were found in the small intestine and pyloric caeca. Lesser amounts were found in rectum and gastric antrum extracts. In some fish, extracts of these regions contained no detectable CCK-li. Rainbow trout brain extracts contained CCK-li that co-eluted with CCK-8 in gel permeation chromatography whereas CCK-li extracted from the various gut regions exhibited marked molecular heterogeneity. Tissue distribution and apparent molecular size of CCK-li in trout is very similar to mammals for brain but distinct from the mammalian pattern in the gut.
authors.forename: S R
authors.initials: SR
authors.lastname: Vigna
authors.forename: B L
authors.initials: BL
authors.lastname: Fischer
authors.forename: J L
authors.initials: JL
authors.lastname: Morgan
authors.forename: G L
authors.initials: GL
authors.lastname: Rosenquist
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping; D002766:Cholecystokinin / Q000276:immunology / Q000378:metabolism*; D004064:Digestive System / Q000378:metabolism*; D011863:Radioimmunoassay; D012487:Salmonidae / Q000378:metabolism*; D014337:Trout / Q000378:metabolism*
chemical_list: D002766:Cholecystokinin