Effect of implanted ethylene-vinyl alcohol copolymer matrices containing 5-fluorouracil on Ehrlich ascites carcinoma.
The antitumour activity of ethylene-vinyl alcohol (EVAl) copolymer matrices containing 5-fluorouracil (5-FU) was evaluated against Ehrlich ascites carcinoma in mice. A prolongation of the life-span of tumour-bearing mice following intraperitoneal implantation of therapeutic matrices was noted. These results indicated that EVAl matrices containing 5-FU may be effective in cancer chemotherapy. Matrices composed of EVAl copolymer could be useful vehicles for implanted, inserted, or surface-applied delivery systems for anticancer agents.
Miyazaki
S
S
Takeuchi
S
S
Sugiyama
M
M
Takada
M
M
Hosokawa
M
M
Koga
Y
Y
Kobayashi
H
H
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004343:Drug Implants; D005472:Fluorouracil / Q000008:administration & dosage* / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011145:Polyvinyls / Q000008:administration & dosage*
D004343:Drug Implants; D011145:Polyvinyls; C020320:ethylene-vinyl alcohol copolymer; D005472:Fluorouracil