title: The subcellular distribution of DL-[3H]2-amino-4-phosphonobutyrate binding sites in the rat brain.
abstract: The subcellular distribution of DL-[3H]2-amino-4-phosphonobutyrate binding sites in rat brain was examined. Binding sites for this radioligand, which selectively labels a chloride/calcium-dependent subpopulation of glutamate binding sites, were highly concentrated in synaptic membrane fractions. This is wholly consistent with the proposed involvement of this site in physiological responses.
authors.forename: S P
authors.initials: SP
authors.lastname: Butcher
authors.forename: P J
authors.initials: PJ
authors.lastname: Roberts
authors.forename: J F
authors.initials: JF
authors.lastname: Collins
mesh_terms: D000613:Aminobutyrates / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D005260:Female; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D008297:Male; D008566:Membranes / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000032:analysis; D013347:Subcellular Fractions / Q000378:metabolism; D013570:Synaptic Membranes / Q000378:metabolism
chemical_list: D000613:Aminobutyrates; D005971:Glutamates; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D018698:Glutamic Acid; C012729:2-amino-4-phosphonobutyric acid