[Effects of converting enzyme inhibition by enalapril on renal hemodynamics in essential arterial hypertension].
The effects of enalapril, an angiotensin-converting enzyme inhibitor, on renal haemodynamics were studied in 10 patients with moderates essential hypertension and no renal failure. Renal blood flow and glomerular filtration were measured (by I 131-hippuran and I 125-iothalamate clearances respectively), before ("placebo period"), and after 15 days of treatment with enalapril 40 mg/day. The drug clearly had an antihypertensive effect: systolic pressure fell from 169 +/- 4 to 149 +/- 5 mmHg (P less than 0.01), and diastolic pressure from 111 +/- 3 to 94 +/- 3 mmHg (P less than 0.01). Enalapril induced marked renal vasodilatation: renal vascular resistance decreased from 0.18 +/- 0.01 to 0.14 +/- 0.01 A.U. (P less than 0.01); renal blood flow was moderately increased (from 764 +/- 43 to 829 +/- 43 ml/min/1.73 m2, P less than 0.05), while glomerular filtration rate remained unmodified (118 +/- 4 versus 120 +/- 6 ml/min/1.73 m2, NS). Under enalapril, the filtration fraction decreased from 0.29 +/- 0.01 to 0.26 +/- 0.01 (P less than 0.01). These results confirmed that enalapril produces dilatation of both the afferent and efferent arterioles - a mechanism that might lower perfusion pressure in the glomerular capillary vessels.
Chaignon
M
M
Service de Néphrologie et Hypertension artérielle, Centre médico-chirurgical Foch, Suresnes.
Moreau
L
L
D000328:Adult; D000368:Aged; D004341:Drug Evaluation; D004656:Enalapril / Q000627:therapeutic use*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation / Q000187:drug effects
D004656:Enalapril
Effets de l'inhibition de l'enzyme de conversion par l'énalapril sur l'hémodynamique rénale dans l'hypertension artérielle essentielle.