title: Possible involvement of dynorphinergic system in nociceptive transmission at spinal level.
abstract: The opioid peptide dynorphin1-32 (DYN1-32, 25 nmol) intrathecally administered causes, in the rat, an elevation of nociceptive threshold of longer duration than that of DYN A, as ascertained by vocalization test. Comparative findings obtained with tail flick test allow to differentiate antinociception from motor dysfunction. The breakdown of DYN A at spinal level is very rapid. The electrical stimulation of the tail associated to a restraint condition of the rat produces a significant increase of immunoreactive DYN in cervical, thoracic and lumbar segments of spinal cord, therefore indicating a correlative, if not causal, relationship between the spinal dynorphinergic system and aversive stimuli.
authors.forename: S
authors.initials: S
authors.lastname: Spampinato
authors.forename: S
authors.initials: S
authors.lastname: Candeletti
authors.forename: P
authors.initials: P
authors.lastname: Romualdi
authors.forename: E
authors.initials: E
authors.lastname: Cavicchini
authors.forename: A E
authors.initials: AE
authors.lastname: Panerai
authors.forename: S
authors.initials: S
authors.lastname: Ferri
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D004399:Dynorphins / Q000031:analogs & derivatives / Q000502:physiology* / Q000627:therapeutic use; D008297:Male; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds; D013116:Spinal Cord / Q000503:physiopathology*; D009435:Synaptic Transmission
chemical_list: D000700:Analgesics; D004399:Dynorphins; C045485:dynorphin (1-32)