Peripheral aromatization: studies on controlling factors.
Using constant infusions of 3H-labeled androgens and 14C-labeled estrogens with measurements of radiolabeled estrogens in blood and/or urine we have carried out studies on the peripheral aromatization of androgens in humans, nonhuman primates, sheep, and rabbits. In the human, aromatization is increased in women as they become postmenopausal, although the mechanism remains uncertain. In humans and cynomolgus monkeys the administration of ACTH and/or glucocorticoids does not increase peripheral aromatization, but results in a slight decrease in the aromatization of androstenedione. The administration of l-thyroxine to cynomolgus monkeys increases peripheral aromatization of androstenedione from basal, 1.16 +/- 0.15%, to 1.71 +/- 0.14% probably due to increased tissue blood flow. The aromatization of testosterone is not affected, probably due to an increase in sex hormone-binding globulin. Peripheral aromatization occurs to a similar degree in humans, rhesus and cynomolgus monkeys, and baboons, but is much lower in sheep and rabbits. The compound 10-(2-propynyl)-estr-4-ene-3,17-dione is an effective inhibitor of the peripheral aromatization of both androstenedione and testosterone.
Longcope
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Department of Obstetrics and Gynecology, University of Massachusetts Medical School, Worcester 01605.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000728:Androgens / Q000378:metabolism; D000735:Androstenedione / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D001141:Aromatase / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D008593:Menopause / Q000187:drug effects; D010215:Papio; D010293:Pargyline / Q000031:analogs & derivatives / Q000494:pharmacology; D011817:Rabbits; D012756:Sheep; D013045:Species Specificity; D013974:Thyroxine / Q000494:pharmacology
D000728:Androgens; D000735:Androstenedione; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D010293:Pargyline; D001141:Aromatase; C033071:plomestane; D013974:Thyroxine; D006854:Hydrocortisone