title: Multiple mu opiate receptors.
abstract: In addition to morphine-selective mu 2 and enkephalin-preferring delta sites, recent evidence supports the presence within the central nervous system of a common site with very high affinity for both enkephalins and opiates termed the mu 1 site. This concept of a common, very high affinity site for multiple neurotransmitters is a unique concept in neuropharmacology, differing from classical transmitter systems which possess multiple receptor classes for a single transmitter. This review will address both the biochemical and pharmacological evidence supporting the existence of this site.
authors.forename: G W
authors.initials: GW
authors.lastname: Pasternak
authors.forename: P J
authors.initials: PJ
authors.lastname: Wood
mesh_terms: D000375:Aging; D000698:Analgesia; D000818:Animals; D001345:Autoradiography; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D004090:Dihydromorphine / Q000378:metabolism; D004723:Endorphins / Q000502:physiology; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000378:metabolism; D016308:Enkephalin, Leucine-2-Alanine; D004745:Enkephalins / Q000378:metabolism; D005033:Ethylmaleimide / Q000494:pharmacology; D009020:Morphine / Q000378:metabolism; D009270:Naloxone / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000502:physiology; D010802:Phylogeny; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D017450:Receptors, Opioid, mu; D012119:Respiration; D019966:Substance-Related Disorders / Q000503:physiopathology; D014018:Tissue Distribution
chemical_list: D004723:Endorphins; D004745:Enkephalins; D018377:Neurotransmitter Agents; D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu; D009270:Naloxone; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C024224:naloxazone; D009020:Morphine; C034643:naloxonazine; D004090:Dihydromorphine; D005033:Ethylmaleimide