Effect of sodium taurocholate and sodium cholate on short-circuit current on amphibian membranes.
The effects of the bile salts, sodium taurocholate (NaTc) and sodium cholate (NaCh), and toad bile gallbladder (bile) on short-circuit current (SCC) across isolated skin, and sodium taurocholate (NaTc) on isolated bladder of Bufo arenarum toads were tested. Sodium taurocholate (NaTc), sodium cholate (NaCh) and toad bile gallbladder (bile) promoted an increase in SCC, when added to the external side. The stimulatory effect was reversible after rinsing the preparation for 60 min. Implications on in vivo renal function of these results are discussed.
Alonso
C E
CE
Coviello
A
A
D000818:Animals; D001646:Bile / Q000502:physiology; D002022:Bufo arenarum; D019826:Cholic Acid; D002793:Cholic Acids / Q000494:pharmacology*; D004553:Electric Conductivity; D005260:Female; D005704:Gallbladder / Q000502:physiology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D012867:Skin / Q000187:drug effects; D012879:Skin Physiological Phenomena; D013656:Taurocholic Acid / Q000494:pharmacology*
D002793:Cholic Acids; D013656:Taurocholic Acid; D019826:Cholic Acid