Protective effect of GABA and sodium valproate on stress-induced gastric lesions in guinea-pigs.
gamma-Aminobutyric acid (GABA) and sodium valproate (VPA) inhibit the formation of stress-induced gastric ulcers in guinea-pigs. The present study was conducted to evaluate the effect of these drugs on the development of cold- and restraint-induced gastric ulcers in guinea-pigs. In control saline-pretreated animals, a 3 h exposure to cold and restriction resulted in the production of gastric ulcers in 9 out of 10 animals. GABA (200 mg kg-1 oral, i.p.) completely prevented the development of gastric ulcers. VPA (100 and 200 mg kg-1 i.p.) exerted no significant effects on the development of gastric ulcers. GABA (100 mg kg-1 oral and i.p.) and VPA (oral) also exhibited partially protective activity. It is suggested that GABA may participate in a physiological modulation of the gastric mucosal barrier, by increasing its resistance to stress-induced lesions.
Miñano
F J
FJ
Serrano
J S
JS
Durán
J A
JA
Sancibrián
M
M
D000818:Animals; D003080:Cold Temperature; D005260:Female; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D008297:Male; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000517:prevention & control*; D013312:Stress, Physiological / Q000503:physiopathology*; D014635:Valproic Acid / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid