title: Amplification of the c-myc oncogene in human plasma-cell leukemia.
abstract: We have examined primary leukemia cells from multiple myeloma and plasma-cell leukemia patients for rearrangement, amplification and expression of c-myc oncogene. No rearrangement or detectable amplification of the c-myc could be found in 21 cases of multiple myeloma. In contrast, 2/3 cases of plasma-cell leukemia showed amplification of the oncogene with concomitant higher level of expression.
authors.forename: J
authors.initials: J
authors.lastname: Sümegi
authors.forename: T
authors.initials: T
authors.lastname: Hedberg
authors.forename: M
authors.initials: M
authors.lastname: Björkholm
authors.forename: T
authors.initials: T
authors.lastname: Godal
authors.forename: H
authors.initials: H
authors.lastname: Mellstedt
authors.forename: M G
authors.initials: MG
authors.lastname: Nilsson
authors.forename: C
authors.initials: C
authors.lastname: Perlman
authors.forename: G
authors.initials: G
authors.lastname: Klein
mesh_terms: D002460:Cell Line; D004262:DNA Restriction Enzymes / Q000378:metabolism; D015245:Deoxyribonuclease BamHI; D015246:Deoxyribonuclease EcoRI; D005784:Gene Amplification; D006801:Humans; D007952:Leukemia, Plasma Cell / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D011061:Poly A / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger; D011061:Poly A; D004262:DNA Restriction Enzymes; D015245:Deoxyribonuclease BamHI; D015246:Deoxyribonuclease EcoRI