title: Role of the Na+K+-ATPase in the cardiotonic action of cardiac glycosides.
abstract: In terms of evolution, the Na+,K+-ATPase is one of the oldest proteins. It is intriguing that this membrane-based enzyme has become biologically consistent with a multifunctional protein. One of the most interesting aspects of the Na+,K+-ATPase is that it contains a specific receptor domain for the oldest plant origin cardiotonic drug and that it is involved in the regulation of myocardial contractility.
authors.affiliation: Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, OH 45267-0575.
authors.forename: A
authors.initials: A
authors.lastname: Schwartz
authors.forename: G
authors.initials: G
authors.lastname: Grupp
authors.forename: E
authors.initials: E
authors.lastname: Wallick
authors.forename: I L
authors.initials: IL
authors.lastname: Grupp
authors.forename: W J
authors.initials: WJ
authors.lastname: Ball
mesh_terms: D000818:Animals; D002301:Cardiac Glycosides / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000201:enzymology; D010042:Ouabain / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology*
chemical_list: D002301:Cardiac Glycosides; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase