Pharmacological changes in dopaminergic systems induced by long-term administration of amantadine.
The pharmacological effects of 6 weeks administration of amantadine was evaluated in the mouse. Motor stimulation induced by amphetamine or the amantadine analog memantine was reduced while that of apomorphine was enhanced by the long-term amantadine treatment. This was accompanied by an increase in the binding of spiroperidol to putative striatal dopamine receptors, without a change in amantadine-induced inhibition of dopamine uptake in the striatum. The possible significance of changes in pre- and postsynaptic dopamine mechanisms is discussed in relation to the anti-parkinson activity of the drug.
Gianutsos
G
G
Chute
S
S
Dunn
J P
JP
D000547:Amantadine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013134:Spiperone / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism; D013997:Time Factors
D000697:Central Nervous System Stimulants; D013134:Spiperone; D000547:Amantadine; D004298:Dopamine