Comparison of oxatomide and clemastine in the treatment of chronic urticaria. A double blind study.
A double-blind trial comparing a new antihistaminic agent (oxatomide) with clemastine was carried out in 30 patients with chronic urticaria. The study included over-all clinical assessment by patient and clinician as well as determination of excretion of 1,4-methylimidazoleacetic acid determined by a reversed-phase ion-pair high-performance liquid chromatographic method. It was found that the effect of oxatomide was equal to that of clemastine.
Beck
H I
HI
Cramers
M
M
Herlin
T
T
Søndergaard
I
I
Zachariae
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D002974:Clemastine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000652:urine; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D011759:Pyrrolidines / Q000627:therapeutic use*; D014581:Urticaria / Q000188:drug therapy* / Q000652:urine
D006634:Histamine H1 Antagonists; D007093:Imidazoles; D010879:Piperazines; D011759:Pyrrolidines; C002667:methylimidazoleacetic acid; D002974:Clemastine; C015408:oxatomide