title: [Psychotropic properties of hormonally inactive derivatives of androstane].
abstract: It has been shown in experiments on noninbred male rats that 17 beta-acetylamino-5-androstene-3 beta,16 beta-diol, 17 beta-amino-5-androstene-3 beta,16 beta-diol hydrochloride, and 17 beta-acetylamino-4-androstene-3,16-dione have an anxiolytic action. These compounds do not exhibit any myorelaxant, anticonvulsant or antineurotic activity common to benzodiazepine tranquilizers. The anxiolytic effect of the compounds under consideration is coupled with the ability to reduce the level of alcoholic motivation in rats.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Burov
authors.forename: N N
authors.initials: NN
authors.lastname: Vedernikova
authors.forename: S N
authors.initials: SN
authors.lastname: Orekhov
authors.forename: L I
authors.initials: LI
authors.lastname: Klimova
mesh_terms: D000437:Alcoholism / Q000188:drug therapy; D000731:Androstanes / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D003220:Conflict, Psychological; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D009126:Muscle Relaxation / Q000187:drug effects; D011619:Psychotropic Drugs; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000731:Androstanes; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D011619:Psychotropic Drugs
vernacular_title: Nekotorye psikhotropnye svoĭstva gormonal'no neaktivnykh proizvodnykh androstana.