Cerebrospinal fluid cholecystokinin, bombesin and somatostatin in schizophrenia and normals.
Cerebrospinal fluid from 31 normals and two groups of phenomenologically similar schizophrenics (n = 72) were collected by identical methods. Radioimmunoassay of CSF was carried out for somatostatin, bombesin, and cholecystokinin. One group of schizophrenics had increased baseline somatostatin and cholecystokinin, and decreased bombesin. No CSF gradient effect was found for the peptides nor were their levels affected by probenecid or pimozide treatment. An inverse correlation was found between bombesin and psychosis rating. Intercorrelation between the peptides and HVA, 5-HIAA, and MHPG were not significant.
Gerner
R H
RH
van Kammen
D P
DP
Ninan
P T
PT
D000293:Adolescent; D000328:Adult; D001839:Bombesin / Q000134:cerebrospinal fluid*; D002766:Cholecystokinin / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000134:cerebrospinal fluid*; D010868:Pimozide / Q000494:pharmacology; D011339:Probenecid / Q000494:pharmacology; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D013004:Somatostatin / Q000134:cerebrospinal fluid*; D014364:Tryptophan / Q000134:cerebrospinal fluid
D010455:Peptides; D010868:Pimozide; D013004:Somatostatin; D014364:Tryptophan; D002766:Cholecystokinin; D011339:Probenecid; D001839:Bombesin; D006854:Hydrocortisone