Recovery of left ventricular function after myocardial infarction can be predicted immediately after thrombolysis by semiquantitative intracoronary thallium and technetium pyrophosphate scintigraphy.
The accuracy with which intracoronary thallium and technetium pyrophosphate scintigraphy during intracoronary thrombolysis predicts myocardial salvage was studied in 58 patients with acute myocardial infarction by comparing the acute scintigraphic findings with subsequent left ventricular function. Scintigrams obtained before and immediately after thrombolysis were interpreted by three independent observers using a scoring system. Regional wall motion in the infarct area was determined from left ventricular (LV) cine angiograms using the center-line method. Patients with mild hypokinesis (hypokinesis less than or equal to -2 SD from normal) could be distinguished from those with severe hypokinesis (hypokinesis greater than -2 SD) using the prethrombolysis thallium score with an accuracy of 83%. Accuracy using the post-thrombolysis score was 76%. When the post-thrombolysis thallium and technetium pyrophosphate scores were combined, differentiation was possible in 91% of all patients studied, and in 100% of patients with anterior myocardial infarction. Thus, analysis of combined thallium and technetium pyrophosphate scintigraphy accurately predicts recovery of LV function after thrombolysis and may be helpful in deciding whether acute percutaneous transluminal coronary angioplasty or bypass surgery should be performed after thrombolysis.
Schofer
J
J
Department of Cardiology, Nuclear Medicine and Biostatistics University Hospital, Eppendorf, Hamburg, F.R.G.
Sheehan
F H
FH
Spielmann
R
R
Wiegand
J
J
Montz
R
R
Reimitz
P E
PE
Mathey
D G
DG
D002302:Cardiac Output / Q000187:drug effects; D003328:Coronary Thrombosis / Q000188:drug therapy; D003331:Coronary Vessels / Q000187:drug effects; D011756:Diphosphates; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011877:Radionuclide Imaging; D012815:Signal Processing, Computer-Assisted; D013300:Streptokinase / Q000008:administration & dosage*; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate; D013794:Thallium Radioisotopes
D011756:Diphosphates; D013794:Thallium Radioisotopes; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium; D013300:Streptokinase