Characterization of the tumour necrosis factor receptor in human placenta.
A specific receptor for tumour necrosis factor present in a purified plasma membrane preparation from the villous tissue of human placenta has been characterized. The data fit a one-class-of-sites model exhibiting a KD = 28.4 (+/- 0.002) nM, with 8.1 (+/- 0.05) X 10(11) receptors mg-1 membrane protein. These data provide evidence for the existence of a specific receptor for a major endotoxin-induced cytokine in the placenta.
Eades
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DK
Department of Biochemistry, School of Medicine, East Carolina University, Greenville, NC 27858.
Cornelius
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Pekala
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PH
D002462:Cell Membrane / Q000032:analysis; D002824:Chorionic Villi / Q000032:analysis*; D005260:Female; D006801:Humans; D011956:Receptors, Cell Surface / Q000032:analysis*; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D011956:Receptors, Cell Surface; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha