Human parvovirus B19-induced transient pancytopenia in a child with hereditary spherocytosis.
We report a child with hereditary spherocytosis who developed human parvovirus B19 (HPV B19)-induced transient pancytopenia. Symptoms of acute-phase illness subsided promptly after infusion of gammaglobulin containing HPV B19 antibody. The HPV B19-containing serum on admission inhibited not only erythroid colony growth but also myeloid and megakaryocyte colony growths. The inhibitory effect was abrogated by convalescent-phase serum or gammaglobulin solution containing HPV B19 antibody. These findings suggest that HPV B19-induced inhibition of haematopoiesis may be pathogenetic for transient bone marrow failure of the patient. The passive immunization may be effective in shortening the duration of acute-phase illness of HPV B19 infection.
Hanada
T
T
Department of Pediatrics, University of Tsukuba, Japan.
Koike
K
K
Takeya
T
T
Nagasawa
T
T
Matsunaga
Y
Y
Takita
H
H
D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D002648:Child; D003114:Colony-Forming Units Assay; D006801:Humans; D008297:Male; D010198:Pancytopenia / Q000209:etiology*; D010321:Parvoviridae / Q000276:immunology; D010322:Parvoviridae Infections / Q000150:complications*; D013103:Spherocytosis, Hereditary / Q000150:complications*
D000914:Antibodies, Viral; D000956:Antigens, Viral