Subtypes of beta adrenergic receptors mediating pigment dispersion in chromatophores of the medaka, Oryzias latipes.
Actions of the adrenergic beta-2 agonists, salbutamol and terbutaline, and the beta-1 antagonists, metoprolol and atenolol, were examined on denervated melanophores and leucophores of a teleost, Oryzias latipes. Beta-2 agonists depressed the pigment-aggregation response of melanophores to norepinephrine, while beta-1 antagonists inhibited the dispersion response of leucophores to isoproterenol but not the melanophore response. These findings suggest that adrenergic receptors mediating pigment dispersion in melanophores are beta-2 and those of leucophores are beta-1. The possible relations between receptor mechanisms and the responses of chromatophores are discussed.
Morishita
F
F
Katayama
H
H
Yamada
K
K
D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D001262:Atenolol / Q000494:pharmacology*; D002449:Cell Aggregation / Q000187:drug effects; D002856:Chromatophores / Q000187:drug effects / Q000378:metabolism*; D003714:Denervation; D004837:Epinephrine / Q000494:pharmacology; D005399:Fishes; D007700:Kinetics; D008547:Melanophores / Q000187:drug effects / Q000378:metabolism; D008790:Metoprolol / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D010860:Pigments, Biological / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012867:Skin / Q000294:innervation*; D013726:Terbutaline / Q000494:pharmacology*
D010860:Pigments, Biological; D011943:Receptors, Adrenergic, beta; D001262:Atenolol; D008790:Metoprolol; D013726:Terbutaline; D000420:Albuterol; D009638:Norepinephrine; D004837:Epinephrine