N-terminal ACTH fragments increase the CSF beta-EP content in Alzheimer type dementia.
Eleven patients with presenile Alzheimer type dementia (ATD) were treated with N-terminal ACTH fragments for 14 days. No change in cognitive functions was observed during the treatment. A significant increase in CSF beta-endorphin (beta-EP) levels was found, while ACTH and beta-lipoprotein remain unaffected. The possibility that ACTH and its moieties could interfere with beta-EP activities in CNS is discussed.
Nappi
G
G
Department of Neurology, C. Mondino Foundation, University of Pavia, Italy.
Facchinetti
F
F
Martignoni
E
E
Petraglia
F
F
Sinforiani
E
E
Bono
G
G
Genazzani
A R
AR
D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use*; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010446:Peptide Fragments / Q000627:therapeutic use*; D001615:beta-Endorphin / Q000134:cerebrospinal fluid*; D008083:beta-Lipotropin / Q000134:cerebrospinal fluid
D010446:Peptide Fragments; C028024:ACTH (4-9); D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D008083:beta-Lipotropin; C028238:ACTH (1-17)