Biotransformation of amitriptyline in man: interaction with phenothiazines.
The biotransformation modification of amitriptyline by phenothiazines has been studied in 65 depressive inpatients. Thirty-four of them were treated with oral amitriptyline and 31 with a combination of amitriptyline and phenothiazine. Urinary and plasmatic results showed a decrease in hydroxylated metabolites of amitriptyline (OHAMTc and OHAMT) in patients with added phenothiazine.
Vandel
S
S
Sandoz
M
M
Vandel
B
B
Bonin
B
B
Allers
G
G
Volmat
R
R
D000328:Adult; D000639:Amitriptyline / Q000008:administration & dosage / Q000378:metabolism*; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D001711:Biotransformation; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010640:Phenothiazines
D014150:Antipsychotic Agents; D010640:Phenothiazines; D000639:Amitriptyline