[Effect of ascorbic acid on the hepatocarcinogenic action of N-nitrosodiethylamine in rats].
It is shown that the ascorbic acid (AA) administration to Wistar male rats (50 mg per animal intraperitoneally 3 times a week) accelerates hepatocarcinogenesis induced by N-nitrosodiethylamine (2.5 mg/kg 6 times a week in drinking water). In this case the activity of glucose-6-phosphate dehydrogenase in liver increases, while that of glucose-6-phosphatase decreases.
Birk
R V
RV
Kil'dema
L A
LA
Teras
L E
LE
D000818:Animals; D000970:Antineoplastic Agents; D001205:Ascorbic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D004128:Dimethylnitrosamine / Q000493:pharmacokinetics / Q000633:toxicity*; D004347:Drug Interactions; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000970:Antineoplastic Agents; D005954:Glucosephosphate Dehydrogenase; D005952:Glucose-6-Phosphatase; D004128:Dimethylnitrosamine; D001205:Ascorbic Acid
Vliianie askorbinovoĭ kisloty na gepatokantserogennoe deĭstvie N-nitrozodiétilamina u krys.