Epidermal-growth-factor receptors and oestrogen receptors in human breast cancer.
Competitive binding and monoclonal antibody staining techniques were used to demonstrate high-affinity (Kd = 1.9 nmol/l) receptors for epidermal growth factor (EGF) in 35 of 104 primary human breast tumours and in 10 of 14 secondary lymph-node deposits. There was a significant inverse relation between the presence of EGF receptors and the presence of oestrogen receptors in the primary tumours (p less than 0.01), and EGF receptors were found in a greater proportion of metastases than primary tumours (p less than 0.01). These results suggest that the presence of EGF receptors is associated with metastatic potential and that the growth of a proportion of poor-prognosis oestrogen-receptor-negative tumours may be regulated by peptide growth factors interacting with the EGF receptor.
Sainsbury
J R
JR
Farndon
J R
JR
Sherbet
G V
GV
Harris
A L
AL
D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D066246:ErbB Receptors; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*
D011956:Receptors, Cell Surface; D011960:Receptors, Estrogen; D066246:ErbB Receptors