title: Production of lactate and tissue plasminogen activator in vitro by seminiferous tubules obtained from adult unilaterally cryptorchid rats.
abstract: Pieces of seminiferous tubules obtained from adult unilaterally cryptorchid rats were incubated in vitro and the effect of FSH on the secretion of lactate and tissue-plasminogen activator (t-PA) was studied. Tubules from abdominal testes secreted less lactate than scrotal tubules. On the other hand, the basal secretion of t-PA was similar but the FSH-stimulated t-PA secretion was larger from abdominal than from scrotal tubules. These results indicate a more specific dysfunction of the Sertoli cells in cryptorchidism than earlier recognized.
mesh_terms: D000005:Abdomen; D000818:Animals; D003456:Cryptorchidism / Q000378:metabolism*; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D007773:Lactates / Q000096:biosynthesis*; D019344:Lactic Acid; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012611:Scrotum; D012671:Seminiferous Tubules / Q000378:metabolism*; D012708:Sertoli Cells / Q000378:metabolism; D013737:Testis / Q000378:metabolism*; D010959:Tissue Plasminogen Activator / Q000096:biosynthesis*
chemical_list: D007773:Lactates; D019344:Lactic Acid; D005640:Follicle Stimulating Hormone; D010959:Tissue Plasminogen Activator