Inhibition of the cataleptic effect of tetrahydrocannabinol by other constituents of Cannabis sativa L.
Tetrahydrocannabinol (THC) induced catalepsy in mice, whereas a cannabis oil (6.68% w/w THC), four cannabinoids and a synthetic mixture did not. Cannabinol (CBN) and olivetol inhibited THC-induced catalepsy in the mornings and the evenings, but cannabidiol (CBD) exhibited this effect only in the evenings. A combination of CBN and CBD inhibited THC-induced catalepsy equal to that of CBN alone in the mornings, but this inhibition was greater than that produced by CBN alone in the evenings.
D000818:Animals; D002186:Cannabinoids / Q000494:pharmacology*; D002188:Cannabis / Q000032:analysis*; D002375:Catalepsy / Q000139:chemically induced*; D002849:Chromatography, Gas; D013759:Dronabinol / Q000037:antagonists & inhibitors* / Q000633:toxicity; D008297:Male; D051379:Mice; D012118:Resorcinols / Q000494:pharmacology
D002186:Cannabinoids; D012118:Resorcinols; C016630:olivetol; D013759:Dronabinol