title: Evidence of an estrogen-like effect of dehydroepiandrosterone on lysyl oxidase activity in the mouse cervix.
abstract: The effect of dehydroepiandrosterone (DHA) on the lysyl oxidase activity in the mouse cervix was studied. Injection of animals ovariectomized 10 days before with 1 mg DHA was followed 24 h later by an increase in enzyme activity, which remained unaltered for 48 h, returning to control values by 96 h after injection. At least 100 micrograms of DHA was required to increase enzyme activity; the maximum effect occurred with 1 mg of the steroid and was comparable to that of 1 microgram estradiol-17 beta. These results demonstrate an estrogen-like effect of DHA on lysyl oxidase activity in mouse cervix. The onset of response was later and the duration of response was longer for DHA than for estradiol-17 beta.
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000818:Animals; D002584:Cervix Uteri / Q000187:drug effects / Q000201:enzymology*; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D010052:Ovariectomy; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism*
chemical_list: D003687:Dehydroepiandrosterone; D000594:Amino Acid Oxidoreductases; D008249:Protein-Lysine 6-Oxidase