[Neurohumoral regulation of immune homeostasis in alcoholic patients].
The effect of neuromediators (DA, GABA) of the neostriatum on the immunogenesis has been studied in 50 noninbred white rats of both sexes weighing 150-200 g, using a new non-cannula method of microinjection of substances into the predetermined brain structures. The results obtained have demonstrated that stimulation of the dopaminergic or blocking of the GABA-ergic system mediated through the impact on the function of neurohormones and cyclic nucleotides increase the body's immunological resistance. In contrast, blocking of the dopaminergic or stimulation of the GABA-ergic systems via the same mechanisms adversely affect immunogenesis. On the basis of the elucidated neurohumoral and immunological impairments the author recommends a pathogenetic treatment of alcoholism taking into account the patients' clinical status. The author points to inadvisability of the use of neuroleptics and GABA-positive drugs for suppressing the pathological craving for alcohol.
D000328:Adult; D000437:Alcoholism / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D004359:Drug Therapy, Combination; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000494:pharmacology / Q000502:physiology*; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000276:immunology
D018377:Neurotransmitter Agents; D000431:Ethanol
Neĭrogumoral'naia reguliatsiia immunnogo gomeostaza u bol'nykh alkogolizmom.