Intracerebroventricular morphine produces diuresis 24 h after previous dynorphin/morphine treatment.
The effect of dynorphin A-(1-13) on morphine-induced urine output was studied in the rat. The previous simultaneous intracerebroventricular (i.c.v.) injection of dynorphin (20 micrograms/rat) and morphine (20 micrograms/rat) altered the response of rat given morphine (20 micrograms/rat) 24 h later, producing a 3-fold increase in urine output. In contrast, previous injection of dynorphin or morphine alone had no effect.
D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D004334:Drug Administration Schedule; D004347:Drug Interactions; D004399:Dynorphins / Q000494:pharmacology*; D005260:Female; D009020:Morphine / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010446:Peptide Fragments; C026843:dynorphin (1-13); D004399:Dynorphins; D009020:Morphine