Effect of Bordetella pertussis adjuvant on parasite-specific IgE response in Paragonimus ohirai-infected rats.
Parasite-specific IgE response in rats infected with metacercariae of the lung fluke, Paragonimus ohirai, was enhanced about 8 times by Bordetella pertussis adjuvant. In rats infected by intraperitoneal transplantation of adult worms, the adjuvant markedly increased the usually low or absent parasite-specific IgE response. The most effective time of the adjuvant administration was different between the two modes of infections.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000918:Antibody Specificity / Q000187:drug effects; D001886:Bordetella pertussis / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology*; D010237:Paragonimiasis / Q000276:immunology*; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology*; D051381:Rats
D000276:Adjuvants, Immunologic; D010567:Pertussis Vaccine; D007073:Immunoglobulin E