Production of lactate and tissue plasminogen activator in vitro by seminiferous tubules obtained from adult unilaterally cryptorchid rats.
Pieces of seminiferous tubules obtained from adult unilaterally cryptorchid rats were incubated in vitro and the effect of FSH on the secretion of lactate and tissue-plasminogen activator (t-PA) was studied. Tubules from abdominal testes secreted less lactate than scrotal tubules. On the other hand, the basal secretion of t-PA was similar but the FSH-stimulated t-PA secretion was larger from abdominal than from scrotal tubules. These results indicate a more specific dysfunction of the Sertoli cells in cryptorchidism than earlier recognized.
D000005:Abdomen; D000818:Animals; D003456:Cryptorchidism / Q000378:metabolism*; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D007773:Lactates / Q000096:biosynthesis*; D019344:Lactic Acid; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012611:Scrotum; D012671:Seminiferous Tubules / Q000378:metabolism*; D012708:Sertoli Cells / Q000378:metabolism; D013737:Testis / Q000378:metabolism*; D010959:Tissue Plasminogen Activator / Q000096:biosynthesis*
D007773:Lactates; D019344:Lactic Acid; D005640:Follicle Stimulating Hormone; D010959:Tissue Plasminogen Activator