Transglutaminase in cell proliferation and transformation.
Transglutaminase (TGase) activity was reduced in intact mitogen-stimulated human peripheral blood lymphocytes (PBL) when compared to intact resting PBL. Moreover, a treatment of the same quiescent immunocompetent cells with purified liver TGase and Ca2+ completely suppressed the mitogen-induced blast transformation. A decrease in TGase activity in neoplastically transformed seminal vesicle epithelial cells with respect to their normal parent counterpart was also observed. Our data support the notion of a possible implication of TGase in cell proliferation and transformation.
D000818:Animals; D001667:Binding, Competitive; D002118:Calcium / Q000494:pharmacology; D002384:Catalysis; D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D003208:Concanavalin A / Q000494:pharmacology; D003470:Culture Media; D006251:Harvey murine sarcoma virus / Q000472:pathogenicity; D007708:Kirsten murine sarcoma virus / Q000472:pathogenicity; D008099:Liver / Q000201:enzymology; D008214:Lymphocytes / Q000473:pathology; D008934:Mitogens / Q000494:pharmacology; D011506:Proteins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D011503:Transglutaminases / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology; D014407:Tumor Cells, Cultured / Q000201:enzymology
D003470:Culture Media; D008934:Mitogens; D011506:Proteins; D003208:Concanavalin A; D011503:Transglutaminases; D002118:Calcium