The effects of cicletanine, a new antihypertensive compound, on the flare and weal response to histamine.
This was an open experimental pilot study in five volunteers to identify any useful effect of cicletanine in the prevention or relief of the flare and weal response to histamine injection on the forearm. Areas of the flare and weal responses to three different concentrations of intradermal histamine injection were determined. Choice reaction time was measured to assess CNS performance. Heart rate, blood pressure and visual near-point were measured as indices of autonomic response. Oral cicletanine (200 mg) reduced the flare and weal response below pretreatment values for at least 8 h (p less than 0.05). There were no apparent changes in heart rate or visual near-point, nor any sedative effects. Diastolic blood pressure was significantly elevated 6 and 8 h after cicletanine (p less than 0.05) but systolic blood pressure was not affected. These results show that cicletanine is a potent non-sedative antihistamine compound.
D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology / Q000627:therapeutic use*; D005542:Forearm; D006339:Heart Rate / Q000187:drug effects; D006632:Histamine; D006634:Histamine H1 Antagonists; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000188:drug therapy*; D008297:Male; D011725:Pyridines; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D000959:Antihypertensive Agents; D004232:Diuretics; D006634:Histamine H1 Antagonists; D011725:Pyridines; D006632:Histamine; C038068:cicletanine