Antibodies to dynorphin A(1-13) but not beta-endorphin inhibit electrically elicited feeding in the rat.
Highly specific antibodies to dynorphin A(1-13), infused into the lateral ventricle, elevated brain stimulation threshold for eliciting feeding behavior. Antibodies to beta-endorphin had little or no effect. Temporal analysis of the anorectic action indicated a striking similarity to the effect of systemically administered naloxone. These findings suggest that central dynorphin is involved in the control of ingestive behavior and that the anorectic action of naloxone may result from antagonism of dynorphinergic transmission.
D000818:Animals; D000906:Antibodies; D002552:Cerebral Ventricles / Q000502:physiology*; D004399:Dynorphins / Q000276:immunology / Q000502:physiology*; D004558:Electric Stimulation; D005247:Feeding Behavior / Q000187:drug effects; D007026:Hypothalamic Area, Lateral / Q000502:physiology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010446:Peptide Fragments / Q000276:immunology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D001615:beta-Endorphin / Q000276:immunology / Q000502:physiology*
D000906:Antibodies; D010446:Peptide Fragments; D009270:Naloxone; D001615:beta-Endorphin; C026843:dynorphin (1-13); D004399:Dynorphins