Effect of ST-567 (a specific bradycardiac agent) in patients with unstable angina and myocardial infarction.
At the time of hospital admission the distinction between reversible ischaemia (angina) and myocardial damage (infarction) is often difficult. Thus it would be advantageous when a similar therapeutic approach could be used in both conditions. Alinidine was given intravenously (10-40 mg) to 24 patients with unstable angina. Heart rate decreased as well as systolic and mean arterial pressure, while stroke volume remained constant. One patient developed heart failure due to an overdose of alinidine (80 mg) in combination with a beta blocker. Furthermore, alinidine was administered in 32 patients with acute myocardial infarction, 23 of these suffered from heart failure. Similar haemodynamic effects were observed while a rise of pulmonary capillary wedge pressure occurred in two patients only. Alinidine appears to be a safe drug for reduction of heart rate in patients with unstable angina and acute myocardial infarction. Further studies to verify the clinical benefit of such a treatment are required.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000787:Angina Pectoris / Q000188:drug therapy*; D000789:Angina, Unstable / Q000188:drug therapy*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D003000:Clonidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006339:Heart Rate / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy*
D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; C022192:alinidine; D003000:Clonidine