[Action of benzodiazepines on the immune response].
The action of benzodiazepine receptor agonists--diazepam and tazepam--on the immune response was studied in CBA mice. It has been shown that benzodiazepine at low doses of 0.5 and 1 mg/kg stimulates and at a dose of 8 mg/kg suppresses the rosette-forming reaction to immunization with 5 X 10(8) sheep red blood cells. Diazepam and tazepam fail to change the immune response if the immunization dose is 5 X 10(6). The dose-dependent effect of diazepine (ranging from stimulation to inhibition) may be caused by different benzodiazepine receptors involved in the process. It is suggested that a certain intensity of the immune response is needed for the manifestation of the immune modulating action of benzodiazepine.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D007111:Immunity, Cellular / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D010076:Oxazepam / Q000494:pharmacology; D012397:Rosette Formation
D014151:Anti-Anxiety Agents; D010076:Oxazepam; D003975:Diazepam
Deĭstvie benzodiazepinov na immunnuiu reaktsiiu.