Buspirone decreases the activity of serotonin-containing neurons in the dorsal raphe in freely-moving cats.
Buspirone, a non-benzodiazepine anxiolytic agent, produced a dose-dependent decrease in the activity of serotonin-containing neurons in the dorsal raphe nucleus of freely-moving cats. The response ranged from no significant change at doses of 0.05 mg/kg to a nearly total suppression of activity at 1 mg/kg. These data suggest that the anxiolytic properties of buspirone may be mediated, at least part, by an action on neurons in the dorsal raphe.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002065:Buspirone; D002415:Cats; D003864:Depression, Chemical; D005260:Female; D008297:Male; D011743:Pyrimidines / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000187:drug effects*; D012701:Serotonin / Q000502:physiology*
D014151:Anti-Anxiety Agents; D011743:Pyrimidines; D012701:Serotonin; D002065:Buspirone