Sipple's syndrome associated with a large prolactinoma.
A 26-year-old male presented with the symptoms and signs of acute congestive heart failure and hypertension. The left ventricle was shown to be thickened and displayed reversible hypokinesia. Further investigations revealed the underlying pathology of a phaeochromocytoma, bilateral medullary thyroid carcinoma (MTC), parathyroid adenoma and macro-prolactinoma. There was a family history of MTC. The echocardiographic features of catecholamine-induced cardiomyopathy were important in this diagnosis. Our research revealed no previous report of Sipple's syndrome associated with a macroprolactinoma. This case, along with the other 13 reports of mixed (type I and II) multiple endocrine neoplasia (MEN), are not within the classical subsets of MEN.
D000236:Adenoma / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000601:surgery; D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use; D002277:Carcinoma / Q000601:surgery; D006801:Humans; D008297:Male; D009377:Multiple Endocrine Neoplasia / Q000628:therapy*; D010282:Parathyroid Neoplasms / Q000601:surgery; D010673:Pheochromocytoma / Q000601:surgery; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000601:surgery
D001971:Bromocriptine; D011388:Prolactin