title: Acute hyperbilirubinaemia in rainbow trout (Salmo gairdneri) caused by resin acids.
abstract: 1. The effects of resin acids on the development of, and recovery from jaundice in rainbow trout were studied. 2. At 0.4 mg/l or higher resin acid concentration, fish developed jaundice in 2-4 days at water temperatures over 17 degrees C and recovered from severe intoxication within 6 days. 3. Jaundice results at least partially from insufficient secretion of conjugated bilirubin into the bile, probably because resin acids and bilirubin share a common secretion pathway. 4. The activity of liver UDP-glucuronosyltransferase and concentration of plasma bilirubin are sensitive indicators of the exposure of trout to discharges containing resin acids.
mesh_terms: D000818:Animals; D001663:Bilirubin / Q000097:blood*; D014453:Glucuronosyltransferase / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology; D012116:Resins, Plant / Q000633:toxicity*; D012487:Salmonidae / Q000097:blood*; D014337:Trout / Q000097:blood*; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D012116:Resins, Plant; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D014453:Glucuronosyltransferase; D001663:Bilirubin