Human red cell volume regulation in hypotonic media.
1. There is substantial evidence for a volume-sensitive KCl cotransport system in young human RBC. 2. The KCl cotransport system becomes latent on cell maturation. 3. There is a correlation between the activation of the KCl cotransporter by either pressure, NEM, ghosting or in certain anemias with disc/cup cell shape change. 4. The stretch-activated KCl transporter may be coupled to some component of the cell cytoskeleton.
D000818:Animals; D004911:Erythrocyte Volume; D006801:Humans; D007038:Hypotonic Solutions; D012756:Sheep
D007038:Hypotonic Solutions