title: Chronic hypnotic efficacy of estazolam.
abstract: The chronic hypnotic efficacy of estazolam 2.0 mg was studied in five female and seven male subjects. Subjects with a complaint of insomnia verified by polysomnography were included in the study. Following a screening and adaptation period, subjects spent two consecutive nights a week in the laboratory. The protocol for medication was placebo for weeks 1, 2, 9 and 10 and estazolam for weeks 3-8. Estazolam 2.0 mg significantly improved sleep onset and total sleep time for up to six weeks of nightly administration without consistent recovery effects upon discontinuation.
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D004949:Estazolam / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D012008:Recurrence; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*
chemical_list: D014151:Anti-Anxiety Agents; D004949:Estazolam