title: Effect of prostaglandin PGE2 on alcohol-induced ulceration in the rat colon.
abstract: The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon. Only prostaglandin E2 treatment significantly reduced mucosal ulceration. Long-term exposure of the rat colon to topical ethanol produced some of the histological changes seen in human colitis.
mesh_terms: D000818:Animals; D003108:Colonic Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D015232:Dinoprostone; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D011239:Prednisolone / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012460:Sulfasalazine / Q000494:pharmacology; D014456:Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control
chemical_list: D011458:Prostaglandins E; D000431:Ethanol; D012460:Sulfasalazine; D011239:Prednisolone; D015232:Dinoprostone