Rearing rats (Rattus norvegicus) at 30 degrees C does not alter sensitivity to noradrenaline.
Rats reared from birth at 30 degrees C show a permanent deficit in body temperature regulation. To test the ability of heat-reared rats to respond to an adrenergic drive, carbon dioxide production was measured at five doses of noradrenaline in rats reared at either 20 or 30 degrees C. Noradrenaline-induced carbon dioxide production was greater at all doses in 20 degrees C rats, but sensitivity to noradrenaline was the same in heat-reared and control animals. These findings support the conclusion that the thermoregulatory deficit induced by heat rearing is due to a change induced in the nervous system.
D000064:Acclimatization / Q000187:drug effects*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D002245:Carbon Dioxide / Q000378:metabolism; D005260:Female; D006358:Hot Temperature; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002245:Carbon Dioxide; D009638:Norepinephrine