The effect of salicylazosulphapyridine (sulphasalazine) on male fertility. A review.
Salicylazosulfapyridine (SASP), a drug used in the treatment of inflammatory bowel diseases, has been reported to depress the fertility in males. Therefore, some authors have proposed SASP as a new lead in the search for a contraceptive for men. Based on a review of the literature, our conclusion is that SASP taken in tolerable doses has not sufficient antifertility effect. Additionally, the drug has too serious and too many side effects to be accepted as a contraceptive. However, the effect on male fertility of other sulfa drugs and related compounds remains to be investigated.
D000177:Acrosome / Q000187:drug effects; D000818:Animals; D002030:Bulbourethral Glands / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003272:Contraceptive Agents, Male / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology*; D003276:Contraceptives, Oral; D004195:Disease Models, Animal; D004347:Drug Interactions; D005298:Fertility / Q000187:drug effects*; D005492:Folic Acid / Q000378:metabolism; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008297:Male; D012460:Sulfasalazine / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects
D003272:Contraceptive Agents, Male; D003276:Contraceptives, Oral; D006728:Hormones; D012460:Sulfasalazine; D005492:Folic Acid