The anti-inflammatory activity of Enicostemma littorale and Mollugo cerviana.
The anti-inflammatory activity of E. littorale and M. cerviana was assessed by carrageenan-induced inflammation and cotton pellet granuloma method in rats. E. littorale and M. cerviana exerted 54 and 26% anti-inflammatory activity for a dose of 100 mg/100 g body wt, respectively, in carrageenan-induced acute inflammation. In chronic inflammation of cotton pellet granuloma, E. littorale and M. cerviana exerted 30 and 46% anti-inflammatory activity at the above dosage, respectively. The optimal dose for these drugs was determined in carrageenan inflammation. The effect of the alcoholic extract of these drugs on human erythrocyte membrane stabilization and inhibition of cobra venom phospholipase A2 was studied in vitro and the drugs were found to be effective. Further, these drugs were found to inhibit the levels of lipid peroxides, acid phosphatase, and gamma-glutamyl transpeptidase activity in the exudate of cotton pellet granuloma. The effects were compared with those of standard anti-inflammatory drug, hydrocortisone. A possible mode of action of these drugs is suggested.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D004910:Erythrocyte Membrane / Q000187:drug effects; D003368:Gossypium; D006099:Granuloma / Q000209:etiology / Q000473:pathology; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D008054:Lipid Peroxides; D010936:Plant Extracts; D002351:Carrageenan; D005723:gamma-Glutamyltransferase; D010741:Phospholipases A; D054467:Phospholipases A2; D000135:Acid Phosphatase; D006854:Hydrocortisone