Effect of medazepam on benzodiazepine receptors in brain of mice with isolation syndrome.
The effect of medazepam in a model of isolation aggression in mice was studied according to Yen et al. It was established that the mean effective dose of medazepam was 250 micrograms/kg and the therapeutic index (LD50:ED50) 6200. The simultaneous biochemical investigations showed a reduction of the affinity and number of benzodiazepine receptors in the brain of aggressive animals. Medazepam 10 mg/kg p.o. led to the restoration of the number of benzodiazepine receptors at a single and 10-day treatment.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D008297:Male; D008472:Medazepam / Q000494:pharmacology*; D051379:Mice; D011963:Receptors, GABA-A / Q000187:drug effects*; D012934:Social Isolation
D014151:Anti-Anxiety Agents; D011963:Receptors, GABA-A; D008472:Medazepam