Localization of the gene for X-linked nephrogenic diabetes insipidus to Xq28.
X-linked nephrogenic diabetes insipidus (NDI) was segregating in a large Indiana family. It was tested for linkage of the NDI gene to X-chromosome molecular markers. Maximum lod scores of 3.15 and 3.01 (theta = 0) obtained for the molecular markers F8A (F8C) and DXS15 (DX13) respectively, indicate that the NDI gene is located in Xq28. A lod score of 3.61 (theta = 0) was obtained with multipoint linkage analysis of F8A and DXS15.
D002874:Chromosome Mapping; D003919:Diabetes Insipidus / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006030:Glycosuria, Renal / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D014960:X Chromosome
D005819:Genetic Markers