title: Pharmacology of GABA receptors on skeletal muscle fibres of the locust (Schistocerca gregaria).
abstract: GABA and the trans isomer of 4-aminocrotonic acid are equally potent at inducing increases in Cl- conductance when applied to distal extensor tibia muscle fibres of the locust (Schistocerca gregaria). beta-Alanine, norvaline, glycine and norleucine induced conductance increases of less than 5% of GABA responses. C9 and meso-di-GABA did not alter input conductance in a manner consistent with actions on a GABA receptor Cl- channel complex. Picrotoxin and anisatin were equally potent GABA antagonists, however bicuculline and penicillin G did not reduce GABA-induced changes in input conductance. Pentobarbitone, in addition to inducing an increase in K+ conductance, potentiated GABA-induced increases in Cl- permeability.
mesh_terms: D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D003998:Dicarboxylic Acids / Q000494:pharmacology; D004553:Electric Conductivity; D018756:GABA Antagonists; D006110:Grasshoppers / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D009132:Muscles / Q000294:innervation; D010424:Pentobarbital / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D003998:Dicarboxylic Acids; D018756:GABA Antagonists; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D010424:Pentobarbital; D001640:Bicuculline