The influence of long-term treatment with haloperidol on neuronal activity and sensitivity in several brain structures of the rat.
The influence of long-term haloperidol pretreatment on neuronal spontaneous activity and transmitter sensitivity was investigated in prefrontal cortex, hippocampus and locus coeruleus. The changes are different in all areas as well as in the transmission systems involved. In particular cases, analogies exist between haloperidol- and isolation-induced changes, reflecting a comparable dopaminergic supersensitivity.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D006220:Haloperidol / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D008125:Locus Coeruleus / Q000187:drug effects / Q000502:physiology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D018377:Neurotransmitter Agents / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D018377:Neurotransmitter Agents; D006220:Haloperidol