The effect of nedocromil on weal reactions in human skin.
1. Nedocromil 2% iontophoresed into human skin had no effect on wealing produced by intradermal histamine, 48/80 or house dust mite antigen. 2. Iontophoresis of 0.002-2% nedocromil itself resulted in dose-related wealing. 3. This wealing was reduced by 62 +/- 8% s.e. mean by the H1-receptor antagonist terfenadine which decreased histamine wealing by 68 +/- 2% s.e. mean. 4. Nedocromil may therefore act as a weak agonist on a skin mast cell receptor concerned with histamine release.
D000328:Adult; D000818:Animals; D000941:Antigens / Q000276:immunology; D001559:Benzhydryl Compounds / Q000494:pharmacology; D003877:Dermatitis, Contact / Q000517:prevention & control*; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006801:Humans; D007478:Iontophoresis; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000276:immunology; D017835:Nedocromil; D011804:Quinolines / Q000008:administration & dosage / Q000494:pharmacology*; D016593:Terfenadine; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D000941:Antigens; D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D011804:Quinolines; D017835:Nedocromil; D003189:p-Methoxy-N-methylphenethylamine; D016593:Terfenadine; D006632:Histamine