[Changes in lung function following administration of eyedrops containing timolol, metipranolol, pindolol and pilocarpine in healthy probands and patients with mild bronchial asthma].
Lung function was studied double blind and randomized in 5 patients with mild asthma bronchiale and 10 normal adults before and 30, 60 and 90 minutes after one drop of 0.5% Timolol, 0.6% Metipranolol or 0.9% NaCl in each eye. In the asthmatics bronchoconstriction was seen after both beta-receptor blocking agents, more pronounced after Timolol than after Metipranolol. There was a decrease in the forced expiratory volume in one second (FEV1.0) of 32, respectively 18%. No changes were observed in the normal subjects. In a separate study no significant changes were seen in the mean values of 10 other asthmatic subjects after 1% Pindolol, 3% Pilocarpin or 0.9% NaCl. However, in two patients FEV1.0 was reduced by 15% and 20% of the control values after applying Pindolol. In summary, not only beta-receptor-blocking agents without ISA produce a bronchoconstriction in asthmatic subjects, but also beta-blocker with ISA in individual cases.
D000403:Airway Resistance / Q000187:drug effects; D001249:Asthma / Q000139:chemically induced*; D001986:Bronchial Spasm / Q000139:chemically induced*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D008176:Lung Volume Measurements; D014290:Metipranolol / Q000009:adverse effects*; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000009:adverse effects*; D010869:Pindolol / Q000009:adverse effects*; D011412:Propanolamines / Q000009:adverse effects*; D011897:Random Allocation; D013999:Timolol / Q000009:adverse effects*
D009883:Ophthalmic Solutions; D011412:Propanolamines; D010862:Pilocarpine; D013999:Timolol; D010869:Pindolol; D014290:Metipranolol
Anderungen der Lungenfunktion nach Timolol-, Metipranolol-, Pindolol- und Pilocarpin-haltigen Augentropfen bei Gesunden und Patienten mit leichtem Asthma bronchiale.