title: Electrical and mechanical activity in heart tissue of flounder and rainbow trout during acidosis.
abstract: 1. Twitch force and voltage across the sarcolemma were measured in heart tissue of flounder and rainbow trout. 2. For the trout heart, hypercapnia was followed by a loss of force and an action potential prolongation. 3. This was also observed for the flounder heart, but only initially. 4. About 5 min after the onset of hypercapnia, an increase in force and a shortening of the action potential occurred in the flounder heart. 5. After about 30 min of hypercapnia a decrease in force and a prolongation of the action potential slowly appeared. 6. These results can be interpreted in terms of a species-dependent effect of acidosis on the cellular Ca2+ handling and the influence of intracellular Ca2+ on the action potential.
mesh_terms: D000138:Acidosis / Q000503:physiopathology / Q000662:veterinary*; D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000502:physiology; D002245:Carbon Dioxide / Q000378:metabolism; D004553:Electric Conductivity; D005393:Fish Diseases / Q000503:physiopathology*; D005412:Flatfishes; D005432:Flounder; D006321:Heart / Q000503:physiopathology*; D006935:Hypercapnia / Q000503:physiopathology / Q000662:veterinary; D008564:Membrane Potentials; D008839:Microelectrodes; D012487:Salmonidae; D012508:Sarcolemma / Q000503:physiopathology; D014337:Trout
chemical_list: D002245:Carbon Dioxide; D002118:Calcium