[Effect of subchronic administration of phenazepam and synthetic antioxidants on the functional status of synaptic membranes in the cerebral cortex of rats subjected to prolonged stress].
Monoamine oxidase activity, lipid peroxidation and membrane structure were tested after chronic stress and 7-day treatment with drugs in the brain cortex synaptosomal membranes of rats. The most potent corrector of stress-induced changes, as compared to hydrophobic antioxidant dibunol and tranquilizer phenazepam, was compound 3-OP, a hydrophilic antioxidant.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage*; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008054:Lipid Peroxides / Q000096:biosynthesis; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D010847:Picolines / Q000008:administration & dosage; D051381:Rats; D013315:Stress, Psychological / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D013570:Synaptic Membranes / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013997:Time Factors
D014151:Anti-Anxiety Agents; D000975:Antioxidants; D001570:Benzodiazepinones; D008054:Lipid Peroxides; D010847:Picolines; D001569:Benzodiazepines; D002084:Butylated Hydroxytoluene; C017928:phenazepam; D008995:Monoamine Oxidase; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Vliianie subkhronicheskogo vvedeniia fenazepama i sinteticheskikh antioksidantov na funktsional'noe sostoianie sinapticheskikh membran kory golovnogo mozga krys, podvergnutykh dlitel'nomu stress-vozdeĭstviiu.