Intra-cerebral cysteamine infusions attenuate the motor response to dopaminergic agonists.
Previous studies have suggested that somatostatin neurons in the basal ganglia may be involved in motor activity. In the present experiments, the effects of cysteamine, a drug which reduces somatostatin levels, on the basal and dopamine-mediated motor activities were examined in the rat. Neither intra-striatal nor intra-accumbens infusions of cysteamine had any effect on motor activity prior to the administration of dopamine agonists. However, intra-striatal cysteamine infusions reduced the duration of the stereotypic behavior induced by systemic apomorphine. In addition, intra-accumbens infusions of cysteamine produced a slight reduction in the locomotor response induced by amphetamine. The direct intra-cerebral infusion of cysteamine produced a significant depletion in the levels of somatostatin at the site of injections as measured by radioimmunoassay. These results indicate that somatostatin neurons in the basal ganglia may modulate the motor responses following dopaminergic activation, and further support the presence of a dopamine-somatostatin interaction in this region.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002421:Caudate Nucleus / Q000187:drug effects*; D003543:Cysteamine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009434:Neural Pathways / Q000187:drug effects; D009714:Nucleus Accumbens / Q000187:drug effects*; D011699:Putamen / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D012686:Septal Nuclei / Q000187:drug effects*; D013004:Somatostatin / Q000502:physiology; D013239:Stereotyped Behavior / Q000187:drug effects*
D011954:Receptors, Dopamine; D013004:Somatostatin; D003543:Cysteamine; D001058:Apomorphine; D003913:Dextroamphetamine