Antimicrobial properties of antiseptic-impregnated biological dressings.
Three antiseptics--chlorhexidine acetate, silver nitrate and povidone-iodine--were incorporated into biological dressings (human skin and amnio-chorion) and evaluated in vitro against disparate micro-organisms. Results indicated that antimicrobial levels of chlorhexidine and silver were released from the dressings over a clinically relevant time period, whereas povidone-iodine was ineffective. Chlorhexidine dressings demonstrated broad-spectrum activity, whereas silver dressings were most effective against Pseudomonas aeruginosa.
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001458:Bandages; D001684:Biological Dressings; D002176:Candida albicans / Q000187:drug effects; D002710:Chlorhexidine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D011206:Povidone-Iodine / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012835:Silver Nitrate / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
D000891:Anti-Infective Agents, Local; D011206:Povidone-Iodine; D012835:Silver Nitrate; D002710:Chlorhexidine