title: The mode of action of guanidine on mouse motor nerve terminals.
abstract: The action of guanidine on presynaptic membrane currents has been investigated to elucidate its facilitatory effect on phasic transmitter release at the mouse neuromuscular junction. Guanidine (2-10 mM) produced a near complete inhibition of the fast voltage-dependent K current. This effect is expected to allow an increase in Ca2+ influx and, thereby, in transmitter release upon nerve stimulation. Guanidine failed to block the Ca-dependent K current of the nerve terminals.
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology; D019791:Guanidine; D006146:Guanidines / Q000494:pharmacology*; D008564:Membrane Potentials; D051379:Mice; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology; D011188:Potassium / Q000502:physiology
chemical_list: D006146:Guanidines; D018377:Neurotransmitter Agents; D019791:Guanidine; D011188:Potassium; D002118:Calcium