title: Effects of aging on contributions of dietary fat and triiodothyronine treatment to lipogenic enzyme induction.
abstract: Although lipogenic enzyme inductions are reduced by fat feeding, this reduction decreases with aging and is particularly detectable in the case of acetyl-CoA carboxylase and fatty acid synthetase activities. On the other hand, the fat-dependent reductions of malic enzyme and acetyl-CoA carboxylase were consistently relieved by triiodothyronine (T3) treatment. The effects of T3 treatment on these enzyme inductions were greater in 10-month-old rats than in 1-month-old rats, while the carbohydrate-dependent induction and the fat-dependent reduction of the enzymes decreased with aging. In these animals, alterations in malic enzyme mRNA translational activities were roughly in parallel to the enzyme activities. Therefore, the age-dependent alterations in effects of T3 treatment and fat on malic enzyme induction do not appear to occur in post-translation.
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000096:biosynthesis; D000273:Adipose Tissue / Q000032:analysis; D000375:Aging; D000818:Animals; D001835:Body Weight; D004041:Dietary Fats / Q000494:pharmacology*; D004790:Enzyme Induction; D064429:Fatty Acid Synthases / Q000096:biosynthesis; D005954:Glucosephosphate Dehydrogenase / Q000096:biosynthesis; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000201:enzymology; D008291:Malate Dehydrogenase / Q000096:biosynthesis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism; D014284:Triiodothyronine / Q000494:pharmacology*
chemical_list: D004041:Dietary Fats; D008055:Lipids; D014280:Triglycerides; D014284:Triiodothyronine; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D064429:Fatty Acid Synthases; D000103:Acetyl-CoA Carboxylase