Metabolic changes in rat brain synaptosomes after exposure to sulfide in vivo.
The effects of exposure of rats to sulfide and the action of exogenous heme were studied in rat-brain synaptosomes. Exposure to sulfide impaired the respiration of synaptosomes which was reversed by heme (4 mg/kg body weight). Sodium sulfide caused partial inhibition of gamma-aminobutyric acid (GABA) and dopamine uptake, strongly inhibited veratridine-dependent release of these neurotransmitters and reduced veratridine-dependent changes in transmembrane electrical potential. Heme treatment did not reverse these changes.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D006418:Heme / Q000494:pharmacology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013440:Sulfides / Q000633:toxicity*; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism; D014701:Veratridine / Q000494:pharmacology
D018377:Neurotransmitter Agents; D013440:Sulfides; D006418:Heme; D014701:Veratridine