[Comparative study of the effect of muscle relaxants on the intraocular pressure].
Control of intraocular pressure is a major concern in ophthalmic anesthesia, especially in the presence of glaucoma or penetrating eye injury. The use of succinylcholine under these conditions is controversial. This study was undertaken to assess the effects of the neuromuscular blocking agents succinylcholine, pancuronium, metocurine, vecuronium, and atracurium on the intraocular pressure of dogs. The study was performed on five "conditioned" mature male foxhounds. The dogs were intubated immediately after induction with thiopental 10 mg/kg and ventilated with an O2/N2O mixture (FIO2 = 0.33). The ventilation was controlled to maintain an endtidal CO2 concentration of 5 vol.%. and anesthesia maintained with a fentanyl infusion of 10 micrograms/kg per hour. Direct and continuous measurements were taken of blood pressure (MAP), central venous pressure (CVP), and intra-ocular pressure (IOP), the latter via a 22-gauge needle inserted into the anterior chamber of the eye. A force-displacement transducer was attached to the hindpaw to monitor muscle twitch following supramaximal stimulation of the anterior tibial nerve. These four measurements were displayed on a multi-channel polygraph (Figs. 1 and 2). Control values were obtained and then succinylcholine 1 mg/kg, pancuronium 0.1 mg/kg, metocurine 0.3 mg/kg, vecuronium 0.1 mg/kg, or atracurium 0.4 mg/kg were given in a randomized fashion and on different days. Measurements of heart rate (HR), MAP, CVP, and IOP were noted at 2, 5, 10, 20, and 30 min after giving the neuromuscular blocking agent. The results, as displayed on the polygraphy, indicate that the least effect on IOP and cardiovascular state followed neuromuscular blockade with vecuronium and atracurium.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D001279:Atracurium / Q000494:pharmacology; D004285:Dogs; D007275:Injections, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects*; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000494:pharmacology*; D010197:Pancuronium / Q000494:pharmacology; D012107:Research Design; D014403:Tubocurarine / Q000031:analogs & derivatives / Q000494:pharmacology; D014673:Vecuronium Bromide / Q000494:pharmacology
D009466:Neuromuscular Blocking Agents; D001279:Atracurium; D014673:Vecuronium Bromide; D010197:Pancuronium; C032943:metocurine; D014403:Tubocurarine
Vergleichende Untersuchung zur Wirkung von Muskelrelaxantien auf den intraokulären Druck.