Combined cyclophosphamide and corticosteroid-induced remission in severe glomerulopathy associated with systemic vasculitis.
Three patients with systemic vasculitis and severe renal disease as major manifestations are reported. In 2 cases, rapidly progressive glomerulonephritis presented as oliguric renal failure. In the third case, the clinical picture was severe nephrotic syndrome with decreased renal function. Combined cyclophosphamide and corticosteroid treatment resulted in dramatic improvement of renal function and remission of nephrotic syndrome. In 2 cases, histological improvement was documented by repeated kidney biopsy. The optimal duration of cyclophosphamide therapy has to be determined.
D000328:Adult; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D010488:Polyarteritis Nodosa / Q000150:complications; D011241:Prednisone / Q000627:therapeutic use*; D014657:Vasculitis / Q000150:complications / Q000188:drug therapy*
D003520:Cyclophosphamide; D011241:Prednisone; D008775:Methylprednisolone