title: Severe premenstrual exacerbations of asthma: effect of intramuscular progesterone.
abstract: Three patients with severe premenstrual exacerbations of asthma are reported. None had responded to conventional treatment, including high-dose corticosteroids. In all cases there was a striking fall premenstrually in peak flow rate. The addition of intramuscular progesterone (100 mg daily in two cases and 600 mg twice a week in one) to the regimen eliminated the premenstrual dips in peak flow, and daily doses of prednisolone were reduced in the three patients.
mesh_terms: D000328:Adult; D001249:Asthma / Q000188:drug therapy / Q000209:etiology*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007273:Injections, Intramuscular; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011293:Premenstrual Syndrome / Q000150:complications* / Q000188:drug therapy; D011374:Progesterone / Q000008:administration & dosage* / Q000627:therapeutic use; D012008:Recurrence
chemical_list: D011374:Progesterone; D011239:Prednisolone