[Effect of anxiolytics--buspirone and diazepam--on the prolactin, thyrotropin and cortisol content of the blood in the green monkey].
The influence of two anxiolytics--diazepam and buspirone--on prolactin, thyrotrophin and cortisol levels in green monkey (Cercopithecus aethiops) plasma was studied 30 min following i/m injection. Diazepam at 1 mg/kg decreased prolactin and cortisol levels by 30-50% compared to the control animals. Buspirone at 2.5-10 mg/kg induced a 7-10-fold increase in prolactin level but did not change cortisol and thyrotrophin concentration. Buspirone analog--Mj 138-05 at 10 mg/kg produced a 2-3-fold increase in plasma prolactin content in some animals, while at a dose of 5 mg/kg it exerted no detectable effect. Possible neurochemical mechanisms of the effects observed are discussed.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002065:Buspirone; D002522:Chlorocebus aethiops; D003975:Diazepam / Q000494:pharmacology*; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D011388:Prolactin / Q000097:blood*; D011743:Pyrimidines / Q000494:pharmacology*; D013972:Thyrotropin / Q000097:blood*; D013997:Time Factors
D014151:Anti-Anxiety Agents; D011743:Pyrimidines; D011388:Prolactin; D013972:Thyrotropin; C039979:gepirone; D003975:Diazepam; D002065:Buspirone; D006854:Hydrocortisone
Vliianie anksiolitikov--buspirona i diazepama--na soderzhanie prolaktina, tireotropina i kortizola v krovi zelenoĭ martyshki.