A platelet-aggregating and hypotensive phospholipid isolated from bovine brain.
A phospholipid that differs from known active lipids and causes potent platelet aggregation and weak hypotension has been isolated from bovine brain. Its platelet aggregating effect on heparinized platelet-rich plasma from rabbits, was at a threshold concentration of about 0.2 nmol ml-1 as phosphorus. The effect was inhibited by CV-3988. The phospholipid was converted by diazomethane treatment to another active lipid that caused short-term hypotension, but not platelet aggregation, rather it inhibited the aggregation of rabbit heparinized platelets induced by platelet-activating factor.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001923:Brain Chemistry; D002417:Cattle; D003978:Diazomethane / Q000494:pharmacology; D066298:In Vitro Techniques; D010742:Phospholipid Ethers; D010743:Phospholipids / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013844:Thiazoles / Q000494:pharmacology
D010742:Phospholipid Ethers; D010743:Phospholipids; D010972:Platelet Activating Factor; D013844:Thiazoles; D003978:Diazomethane; C037913:CV 3988