[Comparative study of the relative hydrophobicity and interaction with striatal dopamine receptors in the bull of representative dialkylaminoalkyl and dialkylaminoacyl phenothiazine derivatives].
Physicochemical properties and ability of some dialkylaminoalkyl (DAL) and dialkylaminoacyl (DAC) phenothiazine derivatives to interact with bovine striatal dopamine receptors have been investigated. DAC analogs were significantly less effective for the inhibition of [3H]-spiperone-specific binding to D2-receptors. The decrease in lipophilicity observed in DAC agents, as compared to DAL, may be one of the causes for the loss of affinity to these receptors.
D000588:Amines / Q000494:pharmacology; D000814:Aniline Compounds / Q000494:pharmacology; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002417:Cattle; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004347:Drug Interactions; D008297:Male; D010640:Phenothiazines / Q000494:pharmacology*; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D013134:Spiperone / Q000493:pharmacokinetics; D013329:Structure-Activity Relationship; D014316:Tritium
D000588:Amines; D000814:Aniline Compounds; D014150:Antipsychotic Agents; D010640:Phenothiazines; D011954:Receptors, Dopamine; C031611:spiroperidol receptor; D014316:Tritium; D013134:Spiperone
Sravnitel'noe izuchenie otnositel'noĭ gidrofobnosti i vzaimodeĭstviia s dofaminovymi retseptorami striatuma byka nekotorykh predstaviteleĭ dialkilaminoalkil'nykh i dialkilaminoatsil'nykh proizvodnykh fenotiazina.