[Seasonal changes in the behavioral effects of neuroleptics on white rats].
Summarized results of the experiments (conducted in 1981-1984) demonstrate seasonal rhythms of some behavioural effects (catalepsy and depression of locomotor activity) of haloperidol (0.5 mg/kg) and levomepromazine (5 mg/kg) in white rats. In intact rats neuroleptics were more effective in depressing high than low motor activity. Catalepsy induced by single administration of neuroleptics was more pronounced in spring and autumn months. A certain negative correlation exists between seasonal variations of neuroleptic catalepsy and the speed of monoamine (dopamine and serotonin) metabolism in the brain of intact rats.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002375:Catalepsy / Q000139:chemically induced; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D008728:Methotrimeprazine / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012621:Seasons
D014150:Antipsychotic Agents; D008728:Methotrimeprazine; D006220:Haloperidol
Sezonnye izmeneniia povedencheskikh éffektov neĭroleptikov u belykh krys.