Cardiovascular effect of sparteine in anaesthetized dogs with and without blockade of cardiac autonomic nerves.
L-Sparteine sulfate (sparteine, 3 mg/kg) was injected intravenously over 3 min in 12 anaesthetized dogs in order to evaluate the inotropic effect of this antiarrhythmic drug on the heart in intact organisms. There was a discrete decline in left ventricular dP/dtmax which was transient within 9 min. No influence could be detected on right ventricular pressure rise velocity. Aortic pressure increased by about 15% and a parallel increase in left ventricular enddiastolic pressure was observed. Heart rate was slightly diminished. Pharmacological blockade of cardiac autonomic nerves did not influence considerably the effect of sparteine. Pretreatment with captopril and phentolamine did not abolish the vasoconstrictive property which was also present in a reserpine pretreated dog. Sparteine shows no pronounced inotropic effect in the heart in situ. It increases arterial blood pressure by direct vascular constriction.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000768:Anesthesia, General; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D001340:Autonomic Nerve Block; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology; D002319:Cardiovascular System / Q000187:drug effects*; D004285:Dogs; D006321:Heart / Q000294:innervation; D007275:Injections, Intravenous; D009200:Myocardial Contraction / Q000187:drug effects*; D012110:Reserpine / Q000494:pharmacology; D013034:Sparteine / Q000008:administration & dosage / Q000494:pharmacology*; D013268:Stimulation, Chemical
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D013034:Sparteine; D001285:Atropine; D012110:Reserpine; D002216:Captopril