Maternal immunization with P fimbriae for the prevention of neonatal pyelonephritis.
Rhesus monkeys (Macaca mulatta) were immunized with purified P fimbriae from Escherichia coli during the last trimester of pregnancy. Infants born of these mothers were compared with those from nonimmunized rhesus mothers. A delay in the onset of renal disease after bladder infection showed protection from passive immunization. This was associated with a high antibody titer in serum. In addition to delayed onset of renal infection, a decreased number of immunized monkeys developed pyelonephritis.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D010861:Fimbriae, Bacterial / Q000276:immunology*; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008253:Macaca mulatta; D011247:Pregnancy; D011704:Pyelonephritis / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M