[Effect of dopamine on the blood flow in various zones of the kidney cortex and medullary layer in rats].
Phentolamine and propranolol did not alter the kidney response to dopamine whereas haloperidol completely prevented the dopamine vascular and channel effects. The agents inhibiting cyclooxygenase and kallikrein-kinin system do not interfere with an increase in the blood flow or depressing action of the neurotransmitter upon sodium transport in the nephron. The hemodynamic shift occurring under the effect of dopamine in different areas of renal tissue seems to be due to a selective stimulation of vascular DA-receptors and unrelated to an increase in the production of prostaglandins and kinins in the kidneys.
D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D007672:Kidney Cortex / Q000098:blood supply / Q000187:drug effects*; D007679:Kidney Medulla / Q000098:blood supply / Q000187:drug effects*; D007705:Kinins / Q000037:antagonists & inhibitors / Q000502:physiology; D008297:Male; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D051381:Rats; D018002:Receptors, Bradykinin; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology; D011982:Receptors, Prostaglandin / Q000187:drug effects / Q000502:physiology; D012039:Regional Blood Flow / Q000187:drug effects; D013565:Sympatholytics / Q000494:pharmacology; D013997:Time Factors
D007705:Kinins; D011448:Prostaglandin Antagonists; D018002:Receptors, Bradykinin; D011954:Receptors, Dopamine; D017981:Receptors, Neurotransmitter; D011982:Receptors, Prostaglandin; D013565:Sympatholytics; D004298:Dopamine
Vliianie dofamina na krotok v razlichnykh zonakh kory i mozgovogo sloia pochek krys.