title: A histidine-rich protein gene marks a linkage group favored strongly in a genetic cross of Plasmodium falciparum.
abstract: Two histidine-rich protein genes in Plasmodium falciparum are related by an ancestral duplication and interchromosomal transposition. We have followed the inheritance of these genes in a cross between two clones of P. falciparum. Examination of progeny shows that one gene, encoding the protein HRP-II, behaves as expected and may be inherited from either parent. The other gene, encoding HRP-III, has been found to derive from one parent in all progeny examined. We conclude the linkage group marked by HRP-III is favored strongly in the cross. This linkage group spans a region at one end of chromosome 13. Growth studies suggest the favored inheritance is explained by rapid expansion of progeny possessing the HRP-III marker relative to slower growth of progeny without it.
mesh_terms: D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005796:Genes; D008040:Genetic Linkage; D005819:Genetic Markers; D006639:Histidine; D006801:Humans; D008288:Malaria / Q000469:parasitology; D009693:Nucleic Acid Hybridization; D010963:Plasmodium falciparum / Q000235:genetics* / Q000254:growth & development; D012150:Polymorphism, Restriction Fragment Length; D011506:Proteins / Q000235:genetics*; D000099053:Histidine-Rich Glycoprotein
chemical_list: D005819:Genetic Markers; D011506:Proteins; D000099053:Histidine-Rich Glycoprotein; D006639:Histidine