The Duffy blood group is linked to the alpha-spectrin locus in a large pedigree with autosomal dominant inheritance of Charcot-Marie-Tooth disease type 1.
The alpha-spectrin locus (SPTA) on chromosome 1 maps to 1q22-q25 and alpha-spectrin specific probes detect restriction fragment length polymorphisms (RFLPs) with the endonucleases MspI and PvuII. The Duffy blood group (FY) has been mapped to the 1p21-q23 region. We found positive linkage between the alpha-spectrin and the Duffy loci with a maximal Lod score of 3.81 at theta = 0.0 using the computer program MLINK. This indicates that both loci are very closely linked and probably localized to 1q22-q23.
D001789:Blood Group Antigens / Q000235:genetics*; D002607:Charcot-Marie-Tooth Disease / Q000097:blood / Q000235:genetics*; D002874:Chromosome Mapping; D004375:Duffy Blood-Group System / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D009134:Muscular Atrophy, Spinal / Q000235:genetics*; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D013049:Spectrin / Q000235:genetics*
D001789:Blood Group Antigens; D004375:Duffy Blood-Group System; D005819:Genetic Markers; D013049:Spectrin