title: The spectrum of hepatotoxicity due to drugs.
abstract: Drugs in common use can cause toxic effects on the liver which can mimic almost every naturally occurring liver disease in man. Drugs can have direct (metabolite-related) toxic effects; they can also cause deposition of microvesicular fat in hepatocytes; or they can provoke reactions resembling acute alcoholic hepatitis (phospholipidosis) or acute viral hepatitis. Hepatotoxicity can also be part of a general hypersensitivity reaction, or hepatic fibrosis or cholestasis can predominate. Drugs can lead to almost any type of vascular disease in the liver and to benign and malignant tumours.
mesh_terms: D000208:Acute Disease; D000236:Adenoma / Q000139:chemically induced; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002648:Child; D002779:Cholestasis / Q000139:chemically induced; D002908:Chronic Disease; D004342:Drug Hypersensitivity / Q000209:etiology; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000139:chemically induced; D008875:Middle Aged; D004364:Pharmaceutical Preparations / Q000378:metabolism
chemical_list: D004364:Pharmaceutical Preparations