[Effect of anaprilin on the tyrosine hydroxylase activity of the oral mucosa in dogs with experimental stomatitis].
It was shown that in dogs with experimental aphthous stomatitis (ligation of the common bile duct) tyrosine hydroxylase activity and content of catecholamines (CA) in the oral mucosa were increased. Blockade of beta-adrenoreceptors caused by anaprilin (1 mg/kg) led to the further increase of tyrosine hydroxylase activity. A relative decrease of CA content was simultaneously observed.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D009061:Mouth Mucosa / Q000187:drug effects* / Q000201:enzymology; D011433:Propranolol / Q000627:therapeutic use*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013281:Stomatitis, Aphthous / Q000188:drug therapy* / Q000201:enzymology; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D002395:Catecholamines; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D014446:Tyrosine 3-Monooxygenase
Vliianie anaprilina na tirozingidroksilaznuiu aktivnost' slizistoĭ obolochki polosti rta u sobak pri éksperimental'nom stomatite.