title: Osteomyelitis with methicillin-resistant Staphylococcus aureus.
abstract: We describe 10 patients with hospital-acquired osteomyelitis due to methicillin-resistant Staphylococcus aureus. The patients were posttraumatic and eight had a foreign body in situ at the site of infection. Vancomycin therapy in association with radical debridement was followed by clinical and radiological cure in eight patients at 2-3.5 years follow-up, in two of whom a foreign body was left in situ. Only minor adverse effects of vancomycin therapy (one rash, two thrombophlebitis) were seen.
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D003428:Cross Infection / Q000382:microbiology / Q000628:therapy; D003646:Debridement; D005260:Female; D005593:Fracture Fixation, Internal; D050723:Fractures, Bone / Q000150:complications; D006801:Humans; D008297:Male; D008712:Methicillin / Q000494:pharmacology; D008875:Middle Aged; D010019:Osteomyelitis / Q000382:microbiology* / Q000628:therapy; D010403:Penicillin Resistance; D013203:Staphylococcal Infections / Q000628:therapy*; D013211:Staphylococcus aureus / Q000187:drug effects; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D014640:Vancomycin; D008712:Methicillin