Altered neurobiological responses to acute immobilization in social-isolated mice.
Social isolation results in dynamic changes of neurobiological functions. The altered internal state of the CNS is reflected in changes in spontaneous behavior, changed responses to transmission-related substances and changed responsiveness to an additional impairment of normal relations between the organism and its environment. We analysed the influence of an acute 2-hour immobilization on such isolation-dependent changes. Whereas the susceptibility to pentetrazole-induced seizures increased continuously with lengthening of isolation and was not affected by the additional impairment, the responsiveness to transmission-related substances changed dynamically depending upon isolation-induced alterations. An immobilization-induced increase in responsiveness to LSD and propranolol was demonstrable in grouped controls and after short-term isolation. The apomorphine stimulation during prolonged isolation experienced a down- and an upregulation which were repeated in a stronger manner by immobilization responses especially after long-term isolation. It is suggested that the dynamics of isolation-induced changes coincided with changed acute adaptive functions.
D000818:Animals; D001058:Apomorphine; D001921:Brain / Q000503:physiopathology*; D008238:Lysergic Acid Diethylamide; D008297:Male; D051379:Mice; D018377:Neurotransmitter Agents / Q000502:physiology; D010433:Pentylenetetrazole; D011433:Propranolol; D012149:Restraint, Physical; D012640:Seizures / Q000139:chemically induced; D012934:Social Isolation; D013315:Stress, Psychological / Q000503:physiopathology*
D018377:Neurotransmitter Agents; D008238:Lysergic Acid Diethylamide; D011433:Propranolol; D001058:Apomorphine; D010433:Pentylenetetrazole