Reproductive tract lesions in male mice treated neonatally with tamoxifen.
Male mice of the NMRI/Tg strain were treated with tamoxifen for the first 3 days after birth. The affected mice were sterile, with multiple reproductive tract lesions. These lesions included testicular hypoplasia, intraabdominal testes, epididymal cysts, and squamous metaplasia of accessory glands.
D000818:Animals; D000831:Animals, Newborn; D003456:Cryptorchidism / Q000139:chemically induced; D003560:Cysts / Q000139:chemically induced; D004822:Epididymis / Q000187:drug effects / Q000473:pathology; D005837:Genitalia, Male / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008679:Metaplasia / Q000139:chemically induced; D051379:Mice; D008815:Mice, Inbred Strains; D013629:Tamoxifen / Q000633:toxicity*; D013733:Testicular Diseases / Q000139:chemically induced; D013737:Testis / Q000187:drug effects / Q000473:pathology
D013629:Tamoxifen