title: Comparative effect of famotidine and cimetidine on the pharmacokinetics of theophylline in normal volunteers.
abstract: The comparative effect of famotidine or cimetidine on theophylline disposition was determined in healthy volunteers. Cimetidine, but not famotidine, caused a reduction in the rate of elimination of theophylline. The mean total body clearance of theophylline was reduced from 57.6 ml min-1 before cimetidine to 39.5 ml min-1 during cimetidine; and the half-life was prolonged from 8.7 h before cimetidine to 12 h during cimetidine. The volume of distribution and renal excretion of theophylline were not affected by either famotidine or cimetidine.
mesh_terms: D002927:Cimetidine / Q000494:pharmacology*; D015738:Famotidine; D005260:Female; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics*; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D006635:Histamine H2 Antagonists; D013844:Thiazoles; D015738:Famotidine; D002927:Cimetidine; D013806:Theophylline