[Demonstration of seasonal variations of circadian rhythm in gentamicin-induced chrono-nephrotoxicity in rats].
The present study investigates the chronobiological approach of the gentamicin-induced nephrotoxicity in rats treated with a single sublethal dose administered at different times of day and season of year. The nephrotoxicity is appreciated by gamma-glutamyl-transferase and alanine-amino-peptidase, two enzymes of the brush border cells and N-acetyl-beta-D-glucosaminidase, a lysosomal enzyme. These excretions peak out at 8 p.m. and reach a through at 8 a.m. for the experimentation in january-february. In contrast, for the experimentation in June-July, we evidence gamma-glutamyl-transferase and alanine aminopeptidase excretion increased at 2 p.m. and decreased at 8 p.m. So, we evidence with gentamicin not only a circadian but also a seasonal susceptibility in rats.
D000118:Acetylglucosaminidase / Q000652:urine; D000626:Aminopeptidases / Q000652:urine; D000818:Animals; D018826:CD13 Antigens; D002940:Circadian Rhythm; D005839:Gentamicins / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012621:Seasons; D005723:gamma-Glutamyltransferase / Q000652:urine
D005839:Gentamicins; D005723:gamma-Glutamyltransferase; D000118:Acetylglucosaminidase; D000626:Aminopeptidases; D018826:CD13 Antigens
Mise en évidence des variations saisonnières des rythmes circadiens de la chrononéphrotoxicité de la gentamicine chez le rat.