title: Anticholinergic activity of the dopamine receptor agonist, TL-68 (N,N-dipropyl-2-aminotetralin).
abstract: The anticholinergic properties of a dopamine receptor agonist, a non-hydroxylated derivative of N,N-dipropylaminotetralin (TL-68), were evaluated using the guinea-pig isolated tracheal strip and rat phrenic nerve-diaphragm preparations. TL-68 competitively antagonized carbachol-induced contractions in guinea-pig trachea with a pA2 value of 5.88 +/- 0.05. In the rat phrenic nerve-diaphragm preparation, TL-68 was found to be inactive in blocking nicotinic cholinergic receptors.
mesh_terms: D000818:Animals; D003964:Diaphragm / Q000187:drug effects / Q000294:innervation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009281:Naphthalenes / Q000494:pharmacology*; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D010791:Phrenic Nerve / Q000187:drug effects / Q000502:physiology; D011954:Receptors, Dopamine / Q000187:drug effects*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects / Q000294:innervation
chemical_list: D009281:Naphthalenes; D011954:Receptors, Dopamine; D013764:Tetrahydronaphthalenes; C016891:N,N-dipropyl-2-aminotetralin