title: Changes in the aging brain as they affect psychotropics: a review.
abstract: This article reviews a number of neuroanatomic and neurochemical changes that occur in the brain with aging, and focuses specifically on those that may affect the response to psychotropic drugs. We hope to increase physicians' awareness of these "central," or brain, changes, that occur with aging when prescribing and monitoring psychotropic use, since the traditional emphasis in prescribing for the elderly has rested with the review of pharmacokinetic, or "peripheral" organ changes.
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology; D011619:Psychotropic Drugs / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D018377:Neurotransmitter Agents; D011619:Psychotropic Drugs