title: Displaceable somatostatin binding sites in the gray matter and pyramidal paths of the human developing spinal cord.
abstract: The binding of the somatostatin analogue, 125I-iodo-Tyr-[Tyr0,D-Trp8]S14, to the foetal (18- and 24-week-old) and infant (newborn and 17-month-old) spinal cord was examined using in vitro autoradiography. Somatostatin binding sites were detected at cervical, thoracic and lumbosacral levels in foetal as well as in infant spinal cord. The radiolabelling was localized over the grey especially in the superficial layers of the dorsal horn including the substantia gelatinosa and the marginal zone. In foetal and newborn spinal cord, the direct and crossed pyramidal paths exhibited a substantial binding of the ligand. A similar labelling was not observed in the pyramidal paths of a 17-month-old child or in anencephalic newborn spinal cord or previously described in adult. These results emphasize the early presence of somatostatin binding sites during the ontogeny of the human spinal cord. Further, the transient appearance of somatostatin binding sites in the pyramidal paths, prior the myelination, raises the question whether somatostatin receptors could be involved in the maturation of certain normal paths.
mesh_terms: D000375:Aging; D005314:Embryonic and Fetal Development; D005333:Fetus; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011712:Pyramidal Tracts / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D017481:Receptors, Somatostatin; D013004:Somatostatin / Q000378:metabolism*; D013116:Spinal Cord / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism
chemical_list: D017981:Receptors, Neurotransmitter; D017481:Receptors, Somatostatin; D013004:Somatostatin