[Neuroimmunoregulatory properties of short protein fragments in rats exposed to immobilization stress].
The influence of short protein fragments on immobilization stress-induced alterations in neuroendocrine and immune systems (catecholamine content in the striatum, hypothalamus and adrenals, serum corticosterone concentration, specific antibody producing activity) was investigated. Immunoglobulin G fragments--tuftsin, rigin, polar amino acid set--polarin and thymus hormone fragment--thymopoetin, as well as substance P (as reference drug) were administered intraperitoneally at doses of 100 and 500 micrograms/kg 30 min before exposure to stress. Rigin and thymopentin showed high stress-protective activity. It is suggested that similar protein fragments, being endogenously formed, may play a regulating role in neuroimmunological homeostasis during exposure to stress.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D007103:Immobilization; D008297:Male; D018377:Neurotransmitter Agents / Q000627:therapeutic use*; D009842:Oligopeptides / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000627:therapeutic use; D051381:Rats; D013312:Stress, Physiological / Q000209:etiology / Q000517:prevention & control*; D016305:Thymopentin; D013946:Thymopoietins / Q000627:therapeutic use; D014405:Tuftsin / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D018377:Neurotransmitter Agents; D009842:Oligopeptides; D010446:Peptide Fragments; D013946:Thymopoietins; D016305:Thymopentin; D014405:Tuftsin; C031491:rigin
Neĭroimmunoreguliruiushchie svoĭstva korotkikh fragmentov belkov v usloviiakh immobilizatsionnogo stressa u krys.