Clastogenic effects of five carcinogenic-mutagenic chemicals on the cells of the common carp, Cyprinus carpio L.
The cytogenetic effects of various i.p. treatments with five carcinogenic-mutagenic chemicals and three doses for each (aflatoxin B1, Aroclor 1254, benzidine, benzo[a]pyrene and 20-methylcholanthrene), were investigated in the cells of the common carp, Cyprinus carpio. Injection with distilled water and corn oil served as the two control groups. For detecting cytogenetic damage we used two test systems, chromosomal aberrations (CA) in kidney cells and micronucleated erythrocytes (M). At 48 hr after treatment with the chemicals under investigation, the frequencies of CA and M were clearly increased in a dose-response manner compared to the control groups.
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002347:Carps; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D002869:Chromosome Aberrations; D004912:Erythrocytes / Q000187:drug effects / Q000648:ultrastructure; D007668:Kidney / Q000187:drug effects / Q000648:ultrastructure; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology
D002273:Carcinogens; D009153:Mutagens