title: Effect of fenamates on prostaglandin E receptor binding.
abstract: The effect of fenamates on prostaglandin E receptor binding was examined in myometrial samples collected at hysterectomy. Sodium meclofenamate and mefenamic acid inhibited binding of PGE2 to its specific receptor in a dose-dependent manner, with an ED50 of 20 mumol/l and 200 mumol/l, respectively.
mesh_terms: D015232:Dinoprostone; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D009215:Myometrium / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism*; D011982:Receptors, Prostaglandin / Q000187:drug effects* / Q000378:metabolism; D062367:ortho-Aminobenzoates / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D011458:Prostaglandins E; D011982:Receptors, Prostaglandin; D062367:ortho-Aminobenzoates; C001209:fenamic acid; D015232:Dinoprostone