Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors.
The chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myelogenous leukemias, was determined by recombinant inbred and conventional backcross analyses. We mapped Evi-1 to a location approximately 15 cM distal to the carbonic anhydrase locus on murine Chromosome 3. The chromosomal location of the proto-oncogene Nras, and two growth factors, epidermal growth factor (Egf), and the beta subunit of nerve growth factor (Ngfb), which had previously been assigned to Chromosome 3 by somatic cell hybrid analysis, were also determined. The location of Evi-1 is distinct from these three loci and from all other proto-oncogenes, common sites of viral integration, or growth factor loci previously mapped in mouse chromosomes. These results suggest that Evi-1 represents a new locus involved in myeloid disease.
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004815:Epidermal Growth Factor / Q000235:genetics; D007942:Leukemia, Experimental / Q000235:genetics / Q000378:metabolism / Q000382:microbiology; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D012150:Polymorphism, Restriction Fragment Length; D011519:Proto-Oncogenes; D011995:Recombination, Genetic; D012190:Retroviridae / Q000378:metabolism*
D004815:Epidermal Growth Factor