The disposition of pyrimethamine in the rat isolated perfused liver: the effect of suramin.
The pharmacokinetics of pyrimethamine (0.5 mg) were determined in the rat isolated perfused liver in the presence of suramin (17.75 mg). The clearance, half life, area under the curve, and volume of distribution of pyrimethamine were unaffected by the concurrent administration of suramin, as was the hepatic sub-cellular disposition of the drug. This report is of relevance to the future concurrent administration of suramin and pyrimethamine in West Africa.
D000818:Animals; D006207:Half-Life; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011739:Pyrimethamine / Q000378:metabolism*; D051381:Rats; D013498:Suramin / Q000494:pharmacology*
D013498:Suramin; D011739:Pyrimethamine