[Circadian changes in the pharmacokinetics and effects of fenazepam in rats].
It was established that phenazepam is excreted from the rat blood several times more rapidly when administered at night. In this case the minimal pharmacological effect is observed as to various actions. During the drug administration in the morning and evening hours the greatest effect is observed that correlates well with the maximal concentrations of the drug after its administration at this time.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000097:blood* / Q000494:pharmacology; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000097:blood* / Q000494:pharmacology; D002940:Circadian Rhythm / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D051381:Rats; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam
Tsirkadnye izmeneniia v farmakokinetike i éffektakh fenazepama u krys.