Phototoxic potential of mequitazine, a phenothiazine derivative, as determined by the photosensitized action on microbiological systems.
In order to determine phototoxic potential of mequitazine (MQZ), a phenothiazine derivative, in vitro tests were attempted using microbiological systems. When Escherichia coli was irradiated with ultraviolet-A light in the presence of MQZ, the surviving fraction was decreased with increasing fluence. Irradiation of bacteriophage lambda in the presence of the drug decreased the surviving fraction as well. Possible targets for the photosensitized action in these systems were discussed.
D010582:Bacteriophage lambda / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects; D004249:DNA Damage; D004926:Escherichia coli / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000633:toxicity*; D010640:Phenothiazines / Q000633:toxicity*; D010787:Photosensitivity Disorders / Q000139:chemically induced*
D006634:Histamine H1 Antagonists; D010640:Phenothiazines; C006069:mequitazine