[Ca2+ ion enhancement of the inhibitory influence of neuroleptics on the Na, K-ATPase of brain synaptosomes].
In the experiments on synaptosomes from the caudate nucleus of the rat brain, neuroleptic drugs (6 types) were found to inhibit the Na, K-ATPase activity considerably stronger (13-51 times, as compared to IC16 values) in the presence of Ca2+ ions (0.25 mM) than in their absence. The enhancement of the inhibitory activity was due to a decrease in the negative cooperation of neuroleptic interaction with the enzyme seen in the absence of Ca2+.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology*; D002421:Caudate Nucleus / Q000187:drug effects* / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D066298:In Vitro Techniques; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013574:Synaptosomes / Q000187:drug effects* / Q000201:enzymology
D014150:Antipsychotic Agents; D000254:Sodium-Potassium-Exchanging ATPase; D002118:Calcium
Usilenie ionami Ca2+ ingibiruiushchego vliianiia neĭroleptikov na Na, K-ATFazu sinaptosom mozga.