Reduced tyrosine hydroxylase-like immunoreactivity around cerebral arteries after experimental subarachnoid hemorrhage in rats. An immunohistochemical study.
In a subarachnoid hemorrhage (SAH) model of the rat, there is a decreased tyrosine hydroxylase-like immunoreactivity in the adrenergic nerves around cerebral arteries. No altered reactivity is found in the superior cervical ganglion or in the nerve bundles around the internal carotid artery of cervical portion. The results suggest that SAH impairs the initial step of catecholamine synthesis in the adrenergic nerves within the subarachnoid space.
D000320:Adrenergic Fibers / Q000201:enzymology*; D000818:Animals; D002536:Cerebral Arteries / Q000201:enzymology / Q000294:innervation*; D005455:Fluorescent Antibody Technique; D051381:Rats; D011919:Rats, Inbred Strains; D013345:Subarachnoid Hemorrhage / Q000201:enzymology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D014446:Tyrosine 3-Monooxygenase