[A case of adult T-cell leukemia achieving complete remission with epirubicin, vincristine and prednisolone chemotherapy].
A 68-year-old man was referred to our hospital because of generalized lymphadenopathy. His abnormal findings were hepatomegaly, leukocytosis and elevated serum LDH. Anti-ATLA antibody was positive. As about half of the peripheral lymphocytes reacted to the monoclonal antibody CD25, these cells were considered to be compatible with ATL cells having an interleukin-2 receptor. Initially, recombinant beta-interferon was administered, but it was not effective. A combination of vincristine (VCR) and prednisolone (PDN) was partially effective against the lymphadenopathy, but the hepatomegaly and leukocytosis did not improve. 4'-epi-Adriamycin (Epirubicin), at a doses of 20 mg/body, weekly, was subsequently added to VCR + PDN therapy. The patient achieved complete regression 2 months later, and has been in continuous complete remission for more than 3 months.
D000368:Aged; D006800:Deltaretrovirus Infections / Q000188:drug therapy*; D004317:Doxorubicin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D015251:Epirubicin; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage*; D012074:Remission Induction; D014750:Vincristine / Q000008:administration & dosage*
D015251:Epirubicin; D014750:Vincristine; D004317:Doxorubicin; D011239:Prednisolone