Detrimental effect of propylene glycol on natural killer cell and neutrophil function.
Propylene glycol (PG) in a concentration of 0.5-1.0% inhibits natural cytotoxicity and neutrophil chemiluminescence. This is the first reported effect of PG on defence mechanisms in man. PG is frequently used as a vehicle in high concentrations by the pharmaceutical industry and it would be wise to consider its potential immunosuppressive effects in the evaluation of drug formulations.
D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004339:Drug Compounding; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects*; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000494:pharmacology*
D011409:Propylene Glycols; D019946:Propylene Glycol