Response to drugs in schizophrenia: the influence of family history, obstetric complications and ventricular enlargement.
A prospective study of antipsychotic drug treatment showed no difference in response between schizophrenic in-patients with or without a familial predisposition to the illness (N = 53). All patients received at least 600 mg chlorpromazine equivalents antipsychotic medication for 6 weeks. Ventricle brain ratios, ratings of cortical sulcal widening and a history of obstetric complications also failed to account for the variability, but early age of onset was associated with unsatisfactory response.
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001925:Brain Damage, Chronic / Q000150:complications*; D002552:Cerebral Ventricles / Q000473:pathology*; D002746:Chlorpromazine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000188:drug therapy* / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D012565:Schizophrenic Psychology; D014057:Tomography, X-Ray Computed
D014150:Antipsychotic Agents; D002746:Chlorpromazine