Presence of carcinogenic glutamic-acid pyrolysis products in human cataractous lens.
The carcinogenic glutamic-acid pyrolysis products, 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) and 2-amino-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-2), were found to be present in human cataractous lenses, but not in normal bovine lenses. Contents of Glu-P-1 and Glu-P-2 in 35 human cataractous lenses were 832 and 20 ng, respectively. These results indicate that the human cataractous lens is exposed to the fluorescent compounds, carcinogenic glutamic pyrolysis products.
D000368:Aged; D000369:Aged, 80 and over; D002273:Carcinogens / Q000378:metabolism*; D002386:Cataract / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006358:Hot Temperature; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism*; D008875:Middle Aged; D009152:Mutagenicity Tests; D013053:Spectrophotometry
D002273:Carcinogens; D005971:Glutamates; D018698:Glutamic Acid