[Interaction of psychotropic preparations with the synaptic membranes of the cerebral cortex in rats].
Interaction of psychotropic drugs with synaptosomal membranes from rat brain cortex was investigated by fluorescent probes. The data obtained indicate that all studied drugs change the state of membrane's surface. Tranquilizers, unlike antidepressants and neuroleptics, decreased fluorescence of the probe. Neuroleptics, unlike other drugs, penetrated deeper into the membranes hydrophobic core.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects*; D005456:Fluorescent Dyes; D008567:Membranes, Artificial; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013570:Synaptic Membranes / Q000187:drug effects*; D014149:Tranquilizing Agents / Q000494:pharmacology
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D005456:Fluorescent Dyes; D008567:Membranes, Artificial; D011619:Psychotropic Drugs; D014149:Tranquilizing Agents
Vzaimodeĭstvie psikhotropnykh preparatov s sinapticheskimi membranamikory golovnogo mozga krys.