[Characteristics of the presynaptic action of harman and its derivatives compared to benzodiazepine tranquilizers].
In experiments on superfused cerebral hemispheric cortex slices of rats preincubated with 3H-gamma aminobutyric acid (3H-GABA), 3H-serotonin (3H-ST) or 3H-noradrenaline (3H-NA) it was shown that benzodiazepine tranquillizers (chlordiazepoxide and diazepam at the concentration of 3 X 10(-5) M) fail to change basal and slice electrostimulation-induced release of 3H-GABA, depress presynaptic release of 3H-NA and significantly enhance impulse release of 3H-ST. In contrast to benzodiazepine tranquillizers, harmane and its derivatives administered at the same concentration enhance slice electrostimulation-induced release of 3H-GABA, 3H-ST and 3H-NA.
D000470:Alkaloids; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004558:Electric Stimulation; D006247:Harmine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000378:metabolism; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000470:Alkaloids; D014151:Anti-Anxiety Agents; D017981:Receptors, Neurotransmitter; D001569:Benzodiazepines; D012701:Serotonin; D006247:Harmine; D005680:gamma-Aminobutyric Acid; D009638:Norepinephrine
Osobennosti presinapticheskogo deĭstviia garmana i ego proizvodnykh v sravnenii s benzodiazepinovymi trankvilizatorami.