Paternal inheritance of translocation chromosomes in a t(X;21) patient with X linked muscular dystrophy.
A number of DNA probes from the short arm of the X chromosome have been used to study the inheritance of the translocation chromosomes in a girl with an X; autosome translocation and muscular dystrophy. The two translocation chromosomes were found to be derived from the father's single normal X chromosome, ruling out maternal inheritance of a pre-existent mutation and enhancing the concept that the de novo translocation is responsible for the dystrophic phenotype.
D002891:Chromosomes, Human, Pair 21; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D009136:Muscular Dystrophies / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D014178:Translocation, Genetic; D014960:X Chromosome