[Antigenicity study of terazosin].
Antigenicity of terazosin was studied in the experimental animals and the following results were obtained. Terazosin was shown to be non-immunogenic in guinea-pigs and mice when immunized alone or with mixture of terazosin and protein as immunogen. Protein-conjugate of terazosin induced responses of hapten specific antibody when guinea pigs and mice were immunized. However, terazosin alone was shown to be not capable of eliciting any allergic responses. In conclusion, terazosin lacks immunogenicity and eliciting antigenicity in these experimental conditions and this suggests that drug allergic response would either not occur or be minimal, if any, when terazosin is administered clinically.
D000317:Adrenergic alpha-Antagonists / Q000276:immunology*; D000707:Anaphylaxis / Q000209:etiology; D000818:Animals; D000941:Antigens / Q000276:immunology*; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011224:Prazosin / Q000031:analogs & derivatives* / Q000276:immunology; D051381:Rats; D012710:Serum Albumin, Bovine / Q000276:immunology; D013045:Species Specificity
D000317:Adrenergic alpha-Antagonists; D000941:Antigens; D012710:Serum Albumin, Bovine; D007073:Immunoglobulin E; C041226:Terazosin; D010047:Ovalbumin; D011224:Prazosin