Liposome encapsulated subunit (VP1) and virion vaccines against foot-and-mouth disease.
Subunit vaccine prepared from VP1 protein of foot-and-mouth disease virus (FMDV) types 0 and Asia 1 protected guinea pigs against FMD and also induced high levels of antibody. Liposomes have been used as a safe and potent immunological adjuvant for FMD vaccines. Vaccines prepared from inactivated virus types 0 and Asia 1 encapsulated in liposomes protected guinea pigs against challenge with homologous virus and showed good antibody response in pigs on a small scale field trial.
D000276:Adjuvants, Immunologic; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D005537:Aphthovirus / Q000276:immunology*; D004589:Electrophoresis, Disc; D005536:Foot-and-Mouth Disease / Q000517:prevention & control*; D006168:Guinea Pigs; D008081:Liposomes / Q000008:administration & dosage / Q000276:immunology*; D013552:Swine; D014764:Viral Proteins / Q000276:immunology*; D015678:Viral Structural Proteins; D014765:Viral Vaccines / Q000276:immunology
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D008081:Liposomes; D014764:Viral Proteins; D015678:Viral Structural Proteins; D014765:Viral Vaccines