Regional localisations and linkage relationships of seven RFLPs and myotonic dystrophy on chromosome 19.
We have studied the genetic linkage relationships of seven DNA polymorphisms on chromosome 19, with each other and with the myotonic dystrophy locus. The DNA sequences were localised to various regions of the chromosome using translocations in somatic cell hybrids. These results provide the basis for a linkage map of most of chromosome 19, and suggest that the myotonic dystrophy locus is close to the centromere.
D000818:Animals; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19 / Q000648:ultrastructure*; D004247:DNA; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells / Q000032:analysis; D008297:Male; D051379:Mice; D009223:Myotonic Dystrophy / Q000175:diagnosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D014178:Translocation, Genetic
D005819:Genetic Markers; D004247:DNA