Genomic HLA-typing by RFLP-analysis using DR beta and DQ beta cDNA probes reveals normal DR-DQ linkages in patients with multiple sclerosis.
Eighteen MS patients were HLA-typed by RFLP-analysis using DR beta and DQ beta cDNA probes. A closer association to the DQ than to the DR locus was not found in this small material, not even within DR-specificities.
D000328:Adult; D000368:Aged; D004247:DNA; D005260:Female; D008040:Genetic Linkage; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D004247:DNA