Dissolution mechanism of tablets produced from coated lactose powder.
The use of the equation of Kitazawa et al in the analysis of the dissolution process of tablets produced from lactose powder coated with paraffin has suggested either an initial breaking of the tablets into particles that subsequently break down into smaller particles or a progressive breaking of the tablet into smaller particles. The former produces a change in rate constant from k1 to k2.
D007785:Lactose; D010232:Paraffin; D011208:Powders; D012995:Solubility; D013607:Tablets
D011208:Powders; D013607:Tablets; D010232:Paraffin; D007785:Lactose