The adenosine receptor antagonist, 8-phenyltheophylline, causes diuresis and saliuresis in the rat.
The diuretic and adenosine antagonist actions of two alkylxanthines have been compared in the conscious rat. 8-Phenyltheophylline (10 mg kg-1) antagonized adenosine-induced bradycardia in the rat for at least 3 h whereas enprofylline (10 mg kg-1) had no effect on this response. 8-Phenyltheophylline (10 mg kg-1) evoked diuresis and saliuresis in the rat whereas enprofylline (10 mg kg-1) had no effect on excretory parameters. These results indicate that the diuretic action of some alkylxanthines may be related to adenosine antagonism.
D000241:Adenosine / Q000037:antagonists & inhibitors; D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011983:Receptors, Purinergic / Q000378:metabolism*; D012492:Salts / Q000652:urine; D013806:Theophylline / Q000031:analogs & derivatives* / Q000494:pharmacology; D014970:Xanthines / Q000494:pharmacology
D011983:Receptors, Purinergic; D012492:Salts; D014970:Xanthines; D013806:Theophylline; C034347:enprofylline; C028322:8-phenyltheophylline; D000241:Adenosine