Effects of electrical stimulation on intracranial pressure and systemic arterial blood pressure in cats. Part II: Stimulation of cerebral cortex and hypothalamus.
This experimental work was carried out to examine whether activation of autonomic cortical and hypothalamic areas by electrical stimulation is related to changes in the intracranial pressure (ICP) in cats anaesthetized lightly with sodium pentobarbital. Electrical stimulation was performed using a concentric electrode with a train of electrical pulses (pulse duration, 0.4 ms; frequency, 40 Hz; intensity, 50-400 microA). Stimulation of sites in the anterior cingulate gyrus produced a rise in ICP associated with a fall in systemic arterial blood pressure (BP) or with no change in BP. Stimulation of sites in the anterior hypothalamus produced a fall in BP with an increase in ICP. Stimulation of sites in the area extending from the anterior hypothalamus to the posterior hypothalamus produced rises in BP and ICP. These observations suggest that activation of autonomic cortical and hypothalamic areas is involved in changes in ICP.
D000818:Animals; D001794:Blood Pressure; D001931:Brain Mapping; D002415:Cats; D002540:Cerebral Cortex / Q000502:physiology*; D004558:Electric Stimulation; D007031:Hypothalamus / Q000502:physiology*; D007427:Intracranial Pressure