title: High-dose infusion therapy for severe depressions.
abstract: The present paper reports the results of high-dose intravenous antidepressive treatment performed at the Psychiatric Department of the Hungarian Central Hospital in Budapest. Based on the differences in the comparative dexamethasone suppression tests (DSTs), prolactin (PRL) responses and Fischer Symptom Check List (FSCL) scores, it is hypothesized that a high parenterally administered dose of dibenzepine acts differently in comparison to oral drugs, which are extensively metabolized in the hepatic microsomal system. The results obtained so far suggest that the effect of high-dose intravenous dibenzepine in endogenous depressive states is comparable to that of electroconvulsive therapy (ECT), as far as the regression of symptoms and biochemical changes are concerned.
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D003907:Dexamethasone; D003984:Dibenzazepines / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D011569:Psychiatric Status Rating Scales
chemical_list: D003984:Dibenzazepines; D003907:Dexamethasone; D011388:Prolactin