title: Classification of psychotropic drugs by rat EEG analysis: the anxiolytic profile in comparison to the antidepressant and neuroleptic profile.
abstract: Electroencephalograms were recorded from the parietal and frontal cortex of freely moving rats held in constant vigilance by placing them in a slowly turning drum. The effects of 5 clinically effective anxiolytics, buspirone, meprobamate, phenobarbital, chlordiazepoxide and diazepam, were studied after intraperitoneal injection of different doses. After on-line fast Fourier transformation of the EEG signal, the drug effects were quantified by an Analysis of Variance. This resulted in a t profile for each drug dosage. Averaging the t profiles of all dosages of a drug results in a 'drug profile'. Averaging the drug profiles of the 5 anxiolytic drugs tested results in an 'anxiolytic profile'. This profile is characterized by a power decrease from 8 to 11 Hz and above 70 Hz and a power increase from 20 to 60 Hz. The anxiolytic profile is compared with the formerly defined antidepressant and neuroleptic profiles and can be clearly distinguished from the latter two.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000145:classification* / Q000494:pharmacology; D000928:Antidepressive Agents / Q000145:classification* / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000145:classification* / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002065:Buspirone / Q000145:classification / Q000494:pharmacology; D003975:Diazepam / Q000145:classification / Q000494:pharmacology; D004569:Electroencephalography; D008620:Meprobamate / Q000145:classification / Q000494:pharmacology; D010634:Phenobarbital / Q000145:classification / Q000494:pharmacology; D051381:Rats
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D008620:Meprobamate; D003975:Diazepam; D002065:Buspirone; D010634:Phenobarbital