Laxatives and the production of autacoids by rat colon.
The effects of some laxatives were examined on the formation of histamine, 5-hydroxytryptamine (5-HT) and prostaglandin-like material (PG-LM) by rat intestine in-vitro. Castor oil, senna, sulphosuccinate and bisacodyl, but not mannitol or lactulose, in doses that cause laxation, increased the formation of histamine, 5-HT and PG-LM. Indomethacin or hydrocortisone reduced the increase of PG-LM formation. The data support the idea that the laxative effects of these intestinal secretagogues are due to increased intestinal production of PG-LM, histamine and 5-HT.
D000818:Animals; D012898:Autacoids / Q000096:biosynthesis*; D002400:Cathartics / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects* / Q000378:metabolism; D006632:Histamine / Q000096:biosynthesis; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000096:biosynthesis
D012898:Autacoids; D002400:Cathartics; D011453:Prostaglandins; D012701:Serotonin; D006632:Histamine