title: Progressive potential of mild cervical atypia: prospective cytological, colposcopic, and virological study.
abstract: A prospective study of 100 women with cytological and colposcopic evidence of mild cervical atypia consistent with cervical intraepithelial neoplasia (CIN) grade I was started in October, 1983. 26% of early preinvasive cervical lesions progressed to histologically proven CIN III. Spontaneous regression of mild cervical atypia occurred in only 11 cases, and in 4 of these CIN recurred. The overall prevalence of human papillomavirus type 16 (HPV 16) in the study group, detected by filter DNA-DNA hybridisation of a cervical cytological specimen, was 39%. However, 22 of the 26 (85%) cases of progressive disease were positive for HPV 16. Detection of HPV 16 may be a non-invasive way of identifying women at high risk of rapid progression of mild cervical atypia to CIN III.
mesh_terms: D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology; D002584:Cervix Uteri / Q000166:cytology; D003127:Colposcopy; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae; D011446:Prospective Studies; D014412:Tumor Virus Infections / Q000150:complications; D002578:Uterine Cervical Dysplasia / Q000382:microbiology / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology
chemical_list: D004279:DNA, Viral