title: The heme biosynthetic pathway in the regenerating rat liver. The relation between enzymes of heme synthesis and growth.
abstract: Enzymes of heme synthesis, porphyrins and heme content of regenerating rat livers were examined. During the first three days of regeneration the weights of livers of one-third and two-third hepatectomized rats increased 1.5-fold and 2.7-fold and the activity of porphobilinogen deaminase increased 2-fold and 4-fold and was inversely correlated with ferrochelatase activity. delta-Aminolevulinic acid synthase and delta-aminolevulinic acid dehydratase activities were reduced. Concomitantly an increase in the concentration of porphyrins and a decrease in that of heme were observed. The changes in the biosynthetic pathway of heme during rapid growth of the liver are discussed.
mesh_terms: D000642:Ammonia-Lyases / Q000378:metabolism*; D000818:Animals; D005294:Ferrochelatase / Q000378:metabolism; D006418:Heme / Q000096:biosynthesis*; D011163:Hydroxymethylbilane Synthase / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D009929:Organ Size; D011166:Porphyrins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014444:Tyrosine Transaminase / Q000378:metabolism
chemical_list: D011166:Porphyrins; D006418:Heme; D011163:Hydroxymethylbilane Synthase; D014444:Tyrosine Transaminase; D000642:Ammonia-Lyases; D005294:Ferrochelatase