title: Effects of divalent metal ions on the uptake of glutamate and GABA from synaptosomal fractions.
abstract: The effects of divalent metal ions on high affinity uptake glutamate and GABA were examined, using crude and purified synaptosomal fractions prepared from brains of DBA/2CBI. The uptake velocities of both amino acids are severely reduced in the presence of Cu2+, Fe2+ and Zn2+ but remain unaffected by Co2+.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002413:Cations, Divalent / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology*; D007700:Kinetics; D051379:Mice; D008811:Mice, Inbred DBA; D013574:Synaptosomes / Q000378:metabolism; D015032:Zinc / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D002413:Cations, Divalent; D005971:Glutamates; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D003300:Copper; D007501:Iron; D015032:Zinc