HLA and tropical sprue.
In 27 Puerto Rican patients with tropical sprue proven by intestinal biopsy and clinical response to folic acid, HLA type was determined with a microcytotoxicity assay. 25 of these patients had at least one antigen of the Aw-19 series (p = 10(-10)). The strongest association was with Aw-31, for which the relative risk was 10.6 (p = 1.2 X 10(-6)). The absence of a B-locus or haplotype effect suggests a marker association only, rather than an immune association.
D004198:Disease Susceptibility; D005787:Gene Frequency; D005819:Genetic Markers; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens; D006801:Humans; D011647:Puerto Rico; D013182:Sprue, Tropical / Q000235:genetics* / Q000276:immunology
D005819:Genetic Markers; D006680:HLA Antigens; D015234:HLA-A Antigens; C043205:HLA-A19 antigen