Deficiency of membrane-bound dipeptidyl aminopeptidase IV in a certain rat strain.
The activity of membrane-bound dipeptidyl aminopeptidase IV (EC 3.4.14.5) was found to be markedly reduced in the Fischer 344 rat strain compared with that in the Wistar strain. Analysis of membrane proteins by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Ouchterlony immunodiffusion revealed the specific absence of this enzyme molecule in the Fischer 344 strain.
D000818:Animals; D002462:Cell Membrane / Q000201:enzymology*; D018819:Dipeptidyl Peptidase 4; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000172:deficiency*; D004591:Electrophoresis, Polyacrylamide Gel; D005779:Immunodiffusion; D007668:Kidney / Q000201:enzymology; D008297:Male; D008970:Molecular Weight; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D018819:Dipeptidyl Peptidase 4