Ventricular cerebrospinal fluid concentrations of putative amino acid transmitters in Parkinson's disease and other disorders.
Concentrations of putative neuroactive substances glutamate, aspartate, gamma-aminobutyric acid, glycine, proline and ethanolamine were determined in ventricular cerebrospinal fluid collected in patients suffering from Parkinson's disease, pain syndromes or cerebellar tremor. Values are similar to those given in the literature for lumbar cerebrospinal fluid. A decrease in gamma-aminobutyric acid in Parkinson patients, as reported in lumbar cerebrospinal fluid, could not be observed. Further evidence for a rostro-caudal gradient for gamma-aminobutyric acid is supplied. New insights into pathophysiological mechanisms in any of the investigated syndromes may not be derived.
D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000134:cerebrospinal fluid*; D001224:Aspartic Acid / Q000134:cerebrospinal fluid; D019856:Ethanolamine; D004983:Ethanolamines / Q000134:cerebrospinal fluid; D005260:Female; D005971:Glutamates / Q000134:cerebrospinal fluid; D018698:Glutamic Acid; D005998:Glycine / Q000134:cerebrospinal fluid; D006801:Humans; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000134:cerebrospinal fluid*; D010300:Parkinson Disease / Q000134:cerebrospinal fluid*; D011392:Proline / Q000134:cerebrospinal fluid; D014202:Tremor / Q000134:cerebrospinal fluid; D005680:gamma-Aminobutyric Acid / Q000134:cerebrospinal fluid
D000596:Amino Acids; D004983:Ethanolamines; D005971:Glutamates; D018377:Neurotransmitter Agents; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D019856:Ethanolamine; D011392:Proline; D005998:Glycine