Infusion of vecuronium controlled by a closed-loop system.
Closed-loop control of neuromuscular blockade, using a semi-continuous infusion of vecuronium, is described. In 28 patients, the average neuromuscular transmission was between 13 and 17% of control. Requirements for vecuronium averaged 1.1 micrograms kg-1 min-1 (0.8-1.5 micrograms kg-1 min-1), being in the same range as for repeated bolus injections. No side effects were observed. After the infusion was stopped recovery was rapid. Only three patients required induced reversal of blockade.
D005240:Feasibility Studies; D006801:Humans; D007260:Infusion Pumps; D007262:Infusions, Intravenous / Q000295:instrumentation / Q000379:methods*; D009119:Muscle Contraction / Q000187:drug effects; D013997:Time Factors; D014673:Vecuronium Bromide / Q000008:administration & dosage* / Q000494:pharmacology
D014673:Vecuronium Bromide