Effects of divalent metal ions on the uptake of glutamate and GABA from synaptosomal fractions.
The effects of divalent metal ions on high affinity uptake glutamate and GABA were examined, using crude and purified synaptosomal fractions prepared from brains of DBA/2CBI. The uptake velocities of both amino acids are severely reduced in the presence of Cu2+, Fe2+ and Zn2+ but remain unaffected by Co2+.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002413:Cations, Divalent / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology*; D007700:Kinetics; D051379:Mice; D008811:Mice, Inbred DBA; D013574:Synaptosomes / Q000378:metabolism; D015032:Zinc / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D002413:Cations, Divalent; D005971:Glutamates; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D003300:Copper; D007501:Iron; D015032:Zinc