Involvement of prostaglandins in immunosuppression caused by adenovirus in mice.
The effect of intraperitoneally (i.p.) inoculated human adenovirus type 6 (Ad6) was tested for humoral immune response against sheep red blood cells (SRBC) in normal and indomethacin-treated mice, with the aim to elucidate the mode of the virus action in immunosuppression. The results indicate that inhibition of prostaglandin synthesis slightly influences the immunosuppressive effect of the virus. It is very likely that also other mechanisms are involved in the immunosuppression observed.
D000257:Adenoviridae Infections / Q000276:immunology*; D000260:Adenoviruses, Human / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation; D016861:Cyclooxygenase Inhibitors; D007108:Immune Tolerance; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011453:Prostaglandins / Q000096:biosynthesis / Q000276:immunology*
D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D007213:Indomethacin