Atypical germ cells in prepubertal cryptorchid testes.
Four cases of prepubertal cryptorchid testes with atypical germ cells were studied. These cells were characteristically large, showing a wide, pale cytoplasm and a large nucleus with both fine and coarse granular chromatin. Ferritin was shown to be absent. It is possible that these cells are dysplastic in nature and that they could form the basis of a premalignant intratubular lesion. Thus periodic follow-up of these patients is recommended.
D002648:Child; D003456:Cryptorchidism / Q000473:pathology*; D005854:Germ Cells / Q000473:pathology*; D006801:Humans; D008297:Male; D011627:Puberty; D012671:Seminiferous Tubules / Q000473:pathology*; D013737:Testis / Q000473:pathology*