Ketamine blocks an NMDA receptor-mediated component of synaptic transmission in rat hippocampus in a voltage-dependent manner.
We have examined the voltage dependence of the effects of ketamine on synaptic currents in hippocampal CA1 neurons in vitro under conditions where there is a large N-methyl-D-aspartate (NMDA) receptor mediated component of the response. Ketamine reduced inward currents to a greater extent than outward currents of a corresponding size. D-2-Amino-5-phosphonovalerate (APV) substantially reduced the residual outward currents recorded in ketamine, but had only a small effect on the residual inward ones. It is concluded that in this system the action of ketamine in blocking synaptically evoked NMDA receptor-mediated currents shows some voltage dependence.
D015763:2-Amino-5-phosphonovalerate; D000818:Animals; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007649:Ketamine / Q000494:pharmacology*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects*; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D007649:Ketamine; D015763:2-Amino-5-phosphonovalerate; D014633:Valine