Vecuronium and atracurium infusions during hypothermic cardiopulmonary bypass.
Two similar groups of patients undergoing coronary artery bypass grafting received either atracurium or vecuronium infusions for neuromuscular blockade. Both groups demonstrated a marked reduction in neuromuscular blocking requirements during hypothermic bypass at 30 C. The ratio of the dose rates at 30 C to that at 37 C was significantly less with vecuronium (p less than 0.01).
D001279:Atracurium / Q000008:administration & dosage*; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage*; D013997:Time Factors; D014673:Vecuronium Bromide / Q000008:administration & dosage*
D009466:Neuromuscular Blocking Agents; D001279:Atracurium; D014673:Vecuronium Bromide