Single dose phenobarbitone prevents convulsions in cerebral malaria.
48 patients over 6 years of age with strictly defined cerebral malaria were randomised to receive either a single intramuscular injection of phenobarbitone (3.5 mg/kg) or placebo in a double-blind, placebo-controlled study. Phenobarbitone significantly reduced the incidence of subsequent convulsions from 54% to 12.5%, without adverse effects. A single intramuscular injection of phenobarbitone is a simple, cheap, and effective method for prevention of convulsions in cerebral malaria.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000150:complications*; D002648:Child; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008288:Malaria / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000627:therapeutic use*; D011897:Random Allocation; D012640:Seizures / Q000209:etiology / Q000517:prevention & control*
D010634:Phenobarbital