Effect of lapachol, a naphthaquinone isolated from Tectona grandis, on experimental peptic ulcer and gastric secretion.
Lapachol, a naphthaquinone isolated from the roots of Tectona grandis given at a dose of 5 mg kg-1 p.o. twice daily for 3 days was found to have an anti-ulcerogenic effect on subsequently induced experimental gastric and duodenal ulcers in rats and guinea-pigs. Its action appears to be associated with an effect on the protein content of gastric juice, and it reversed aspirin-induced changes in peptic activity, protein and sialic acid.
D000818:Animals; D005260:Female; D005750:Gastric Juice / Q000032:analysis / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D006168:Guinea Pigs; D008297:Male; D009285:Naphthoquinones / Q000494:pharmacology / Q000627:therapeutic use*; D010437:Peptic Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D011506:Proteins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D009285:Naphthoquinones; D011506:Proteins; C008252:lapachol