Taxol and derivatives: a biogenetic hypothesis.
Based on the structural differences of compounds isolated from various species of Taxus, this brief review suggests a biogenetic approach to taxol. This hypothesis could be of some help in the synthesis of this complex molecule exhibiting significant antitumor properties.
D000470:Alkaloids / Q000096:biosynthesis*; D000972:Antineoplastic Agents, Phytogenic / Q000096:biosynthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D017239:Paclitaxel; D010944:Plants / Q000378:metabolism*
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel