[Chrononephrotoxicity of amikacin after 7-day chronic poisoning in rats].
We have studied the chrononephrotoxicity of amikacin during and after a prolonged treatment in rats. Animals received by intramuscular route a daily dose of 400 mg/kg during 7 days at four different times (08:00, 14:00, 20:00 or 02:00). Large time-dependent variations in renal injury had been evidenced by several parameters and particularly by enzymuria. This injury is maximal when administration is made at 14:00. These data confirmed results obtained in previous investigations. The knowledge of chrononephrotoxicity could permit an optimization of drugs in clinics.
D000118:Acetylglucosaminidase / Q000652:urine; D000469:Alkaline Phosphatase / Q000652:urine; D000583:Amikacin / Q000008:administration & dosage / Q000506:poisoning*; D000818:Animals; D002909:Chronobiology Phenomena; D004796:Clinical Enzyme Tests; D007273:Injections, Intramuscular; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000652:urine
D000583:Amikacin; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D000118:Acetylglucosaminidase
Etude de la chrononéphrotoxicité de l'amikacine après intoxication chronique de sept jours chez le rat.