Assignment of a processed mouse Aprt pseudogene to the same chromosome as the functional gene.
A novel genetic system has been used to demonstrate that a processed adenine phosphoribosyltransferase (Aprt) pseudogene is located on mouse chromosome 8, which is the same chromosome that carries the functional Aprt gene. A restriction fragment length polymorphism associated with the pseudogene was found to segregate concordantly with chromosome 8 in APRT- mutants of a near-diploid cell line that had lost one copy of the chromosome.
D000228:Adenine Phosphoribosyltransferase / Q000235:genetics*; D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes; D005796:Genes; D051379:Mice; D009154:Mutation; D010430:Pentosyltransferases / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
D010430:Pentosyltransferases; D000228:Adenine Phosphoribosyltransferase; D004262:DNA Restriction Enzymes