Monoamine oxidase activity in chick cerebral microvessels.
In chick brain microvessels, monoamine oxidase activity using catecholamines (dopamine and noradrenaline) and indoleamines (serotonin and tryptamine) as substrates was higher than that measured in synaptosomes and free mitochondria. In contrast, phenylalkyamines such as tyramine and 2-phenylethylamine were more deaminated in free mitochondria and synaptosomes than in microvessels. These results suggest that the activity of monoamine oxidase towards neurotransmitter amines in microvessels should be considered as a site of inactivation of these neurotransmitters in the chick brain parenchyma.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000098:blood supply*; D002645:Chickens; D008833:Microcirculation / Q000201:enzymology; D008928:Mitochondria / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism; D013574:Synaptosomes / Q000201:enzymology
D001679:Biogenic Amines; D018377:Neurotransmitter Agents; D008995:Monoamine Oxidase