title: A B-cell line having chromosome 14 aberration at break band q11 derived from an adult T-cell leukemia patient.
abstract: A B-cell line having translocations of chromosome 14 at break band q11 (the assigned locus of the alpha-chain gene of the T-cell antigen receptor) and chromosome 3 at break band p25 (the assigned locus of the c-raf-1 oncogene) was established from peripheral blood leukocytes of an adult T-cell leukemia (ATL) patient. The same chromosome 14 aberration at break band q11 and chromosome 3 aberration at break band p25 were also found in fresh T-cell leukemia cells. The B-cell line is surface immunoglobulin (sIg)+, immunoglobulin gene rearrangement+, ATL-specific antigen (ATLA)+, HTLV-1 proviral genome+, Epstein-Barr virus (EBV)-associated nuclear antigen (EBNA)+ and the EBV DNA genome+. The fresh T-leukemic cells were T-cell receptor gene rearrangement+, the HTLV-1 proviral genome+ and EBV DNA genome.
mesh_terms: D001402:B-Lymphocytes / Q000648:ultrastructure*; D002460:Cell Line; D000090266:Chromobox Protein Homolog 5; D002883:Chromosomes, Human, Pair 14; D002893:Chromosomes, Human, Pair 3; D004279:DNA, Viral / Q000032:analysis; D006800:Deltaretrovirus Infections / Q000235:genetics*; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: C000715594:CBX5 protein, human; D004279:DNA, Viral; D011948:Receptors, Antigen, T-Cell; D000090266:Chromobox Protein Homolog 5