title: Effect of electrolytic and chemical ventromedial hypothalamic lesions on food intake, body weight, analgesia and the CNS opioid peptides in rats and mice.
abstract: The hyperphagia and obesity induced by ventromedial hypothalamic (VMH) electrolytic lesions in female rats were associated with a 70-94% decrease in the level of beta-endorphin (beta-E) in the hypothalamus and other regions of brain, but not in the pituitary. Dynorphin (Dyn) and methionine-enkephalin (ME) levels were also decreased. Rats with VMH lesions were less sensitive to the inhibitory effect of naloxone on their food-intake. Mice injected with gold thioglucose (GTG) also showed a decrease in the hypothalamic content of beta-E and Dyn and exhibited 30% less analgesia compared to control mice after cold swim stress.
mesh_terms: D000698:Analgesia; D000818:Animals; D001835:Body Weight; D001921:Brain / Q000502:physiology; D004399:Dynorphins / Q000502:physiology*; D004744:Enkephalin, Methionine / Q000502:physiology*; D005247:Feeding Behavior; D005260:Female; D010902:Pituitary Gland / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D014697:Ventromedial Hypothalamic Nucleus / Q000502:physiology*; D001615:beta-Endorphin / Q000502:physiology*
chemical_list: D004744:Enkephalin, Methionine; D001615:beta-Endorphin; D004399:Dynorphins