Central noradrenergic neurons and vascular non-collagen protein in the initial phase of two-kidney, one-clip renovascular hypertension.
Rats had been given intraventricular injection of 6-hydroxydopamine (6-OHDA) before clipping the unilateral renal artery (2K-1C) that caused selective ablation of the central noradrenergic neurons. Central catecholamines and the in vivo incorporation of 3H-proline into vascular non-collagen protein were determined in 2K-1C rats in the acute hypertensive stage. It is suggested that increased non-collagen protein synthesis in the mesenteric artery and the low level of hypothalamic norepinephrine concentration may participate in the development of 2K-1C hypertension in rats.
D000818:Animals; D001011:Aorta / Q000473:pathology; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000378:metabolism*; D001835:Body Weight; D002395:Catecholamines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology; D006978:Hypertension, Renovascular / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D008638:Mesenteric Arteries / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009638:Norepinephrine / Q000378:metabolism; D009929:Organ Size; D016627:Oxidopamine; D011149:Pons / Q000378:metabolism; D011392:Proline / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D002395:Catecholamines; D006584:Hexamethonium Compounds; D006892:Hydroxydopamines; D018738:Hexamethonium; D016627:Oxidopamine; D011392:Proline; D004298:Dopamine; D009638:Norepinephrine