Hypomagnesaemia, hypoalbuminaemia and plasma lipid changes in rats following the oral administration of ciclosporin.
1. The effects of orally administered ciclosporin (40, 50 or 80 mg/kg body wt) on plasma magnesium, albumin, total cholesterol and triglycerides have been studied in male Wistar rats. 2. Plasma magnesium and albumin were significantly lower in rats dosed with ciclosporin (40, 50 or 80 mg/kg) after 14 days. 3. Variable changes of plasma cholesterol and triglycerides were observed. Some implications of the inter-relationships of magnesium, albumin and plasma lipids in ciclosporin treatment are discussed.
D000284:Administration, Oral; D000818:Animals; D002784:Cholesterol / Q000097:blood; D003524:Cyclosporins / Q000008:administration & dosage / Q000494:pharmacology*; D003864:Depression, Chemical; D008055:Lipids / Q000097:blood*; D008274:Magnesium / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
D003524:Cyclosporins; D008055:Lipids; D012709:Serum Albumin; D014280:Triglycerides; D002784:Cholesterol; D008274:Magnesium