title: Pharmacokinetics of temazepam compared with other benzodiazepine hypnotics--some clinical consequences.
abstract: When the various benzodiazepine hypnotics are studied, large differences are seen with regard to their pharmacokinetic properties and metabolism in man. Some are eliminated from the body at a relatively slow rate (e.g. nitrazepam), others are metabolized rather rapidly (temazepam, triazolam). Some benzodiazepine hypnotics have major active metabolites that are slowly eliminated (flurazepam, quazepam), while others have non-active metabolites (temazepam, lormetazepam). In hypnotic treatment, the duration of drug action should be restricted to the duration of the night, hence a compound with a relatively short elimination half-life may represent a more rational choice. An overview is given of the pharmacokinetics of the currently available benzodiazepine hypnotics with emphasis on temazepam and other hydroxylated benzodiazepines.
mesh_terms: D014151:Anti-Anxiety Agents / Q000097:blood* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D006801:Humans; D007700:Kinetics; D007319:Sleep Initiation and Maintenance Disorders / Q000097:blood* / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013693:Temazepam / Q000097:blood* / Q000627:therapeutic use
chemical_list: D014151:Anti-Anxiety Agents; D013693:Temazepam