Effects of tumor necrosis factor (TNF) on transplanted tumors induced by methylcholanthrene in mice. A histopathologic study.
The effects of a highly purified tumor necrosis factor (TNF) on transplanted methylcholanthrene (Meth A)-induced murine tumors were compared with those of lipopolysaccharide (LPS). TNF caused immediate subepidermal edema and hyperemia followed 2 h later by fibrin thrombi in tumor blood vessels. Finally hemorrhagic necrosis with dispersal of tumor cells occurred. LPS produced similar hemorrhagic necrotizing changes. However, the necrotic action of LPS was delayed and complete tumor regression was not achieved with LPS. These findings suggest that tumor necrosis induced by TNF is due to circulatory disturbance associated with a microvascular injury in the tumor manifested by hyperemia and multiple fibrin thrombi.
D000818:Animals; D005354:Fibrosarcoma / Q000098:blood supply / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D006023:Glycoproteins / Q000627:therapeutic use*; D008070:Lipopolysaccharides / Q000627:therapeutic use; D008748:Methylcholanthrene; D051379:Mice; D008807:Mice, Inbred BALB C; D008833:Microcirculation; D008854:Microscopy, Electron; D009336:Necrosis; D009368:Neoplasm Transplantation; D013927:Thrombosis / Q000139:chemically induced; D014409:Tumor Necrosis Factor-alpha
D006023:Glycoproteins; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D008748:Methylcholanthrene