Secretomotor and mucolytic effects of mabuterol, a novel bronchodilator.
Action of mabuterol, a novel bronchodilator, on the respiratory secretion system was investigated, and the following effects were confirmed: 1) increase of output volume, amounts of protein and pulmonary surfactant in respiratory fluid; 2) decrease of sputum viscosity; 3) fragmentation of the sputum structure and 4) promotion of the mucociliary transport of particles. The results in the present study may, at least partly, substantiate clinical efficacy such as improvement of pulmonary function, favourable effects on expectoration and amelioration of symptoms observed in patients with chronic obstructive pulmonary disease.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D001991:Bronchitis / Q000378:metabolism; D002976:Clenbuterol / Q000031:analogs & derivatives / Q000494:pharmacology*; D010856:Columbidae; D004983:Ethanolamines / Q000494:pharmacology*; D005100:Expectorants; D005260:Female; D008297:Male; D009079:Mucociliary Clearance / Q000187:drug effects*; D010168:Palmitates / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D011817:Rabbits; D013183:Sputum / Q000378:metabolism
D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D005100:Expectorants; D010168:Palmitates; D010713:Phosphatidylcholines; C044573:mabuterol; D002976:Clenbuterol