Effects on mitochondrial metabolism of CCA, one inducer of neuroblastoma differentiation.
CCA, a potent neuroblastoma differentiation inducer, was shown by oxygraphic measurements to reduce significantly the O2 consumption of whole neuroblastoma cells as of mitochondria purified from neuroblastoma or mouse cortex. The effect of CCA on the respiration was compared to those of oligomycin. Our results suggest that the molecular target of CCA is the matrix F1 catalytic component of the F0F1 mitochondrial ATPase.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002540:Cerebral Cortex / Q000378:metabolism; D002999:Clone Cells; D003509:Cyclohexanecarboxylic Acids / Q000378:metabolism / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D009447:Neuroblastoma; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D006180:Proton-Translocating ATPases / Q000037:antagonists & inhibitors
D003509:Cyclohexanecarboxylic Acids; C027655:1-methylcyclohexanecarboxylic acid; D006180:Proton-Translocating ATPases