Release of neurotransmitter amino acids from rat brain synaptosomes and its regulation in aging.
The release of neurotransmitter amino acids 14C-Asp, 14C-Glu and 14C-GABA from rat brain synaptosomes in aging is studied. It is established that K+-induced Ca2+-dependent and Ca2+-independent release of these amino acids decreases significantly in the old animals. K+ (40 mM) stimulates strongly their release for both ages, but the effect of K+ ions in old animals is less marked. Removal of Ca2+ has a greatly inhibitory effect on synaptosomal release in young as well as in old rats. The degree of inhibition does not depend on age, though it takes place at a lower level in old rats.
D000375:Aging / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000502:physiology; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011188:Potassium / Q000502:physiology; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000596:Amino Acids; D005971:Glutamates; D018377:Neurotransmitter Agents; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D011188:Potassium; D002118:Calcium