[Collection of circulating stem cells during remission after chemotherapy in acute leukemia].
The level of circulating myeloid progenitor cells (CFU-G), considered to be a good index of the quantity of circulating hemopoietic stem cells, was measured in the peripheral blood of 5 patients with acute leukemia as they entered first remission. High levels of circulating CFU-G were found in 4 of these 5 patients, depending on the intensity and the number of courses of induction chemotherapy. Repeated cytaphereses were done on 3 of these patients in order to collect and to cryopreserve circulating stem cells, to be used later for autologous transplantation. We propose a model which calculates the number of cytaphereses sufficient to obtain a level of 10(5) CFU-G/kg of weight, considered necessary to achieve a good hemopoietic reconstitution after transplantation.
D000208:Acute Disease; D000328:Adult; D005260:Female; D006098:Granulocytes / Q000473:pathology* / Q000637:transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D007937:Leukapheresis; D007938:Leukemia / Q000097:blood* / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D014182:Transplantation, Autologous
Collection de cellules souches circulantes en sortie d'aplasie post-chimiothérapique dans les leucémies aiguës.