Identification of a murine pan-T cell antigen which is also expressed during the terminal phases of B cell differentiation.
A new rat anti-mouse mAb, designated S7, is described. The antibody, an IgG2a, reacts with all Thy-1.2-positive cells and all granulocytic cells in the marrow. Resting B cells are non-reactive but, during the terminal phases of LPS-induced B cell differentiation, the S7 determinant appears and reaches high levels of expression. S7 will probably be useful in studies aimed at subdividing the later stages of the B cell maturation process.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000937:Antigen-Antibody Reactions; D000954:Antigens, Surface / Q000276:immunology / Q000302:isolation & purification*; D001402:B-Lymphocytes / Q000145:classification / Q000166:cytology* / Q000276:immunology; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D006098:Granulocytes / Q000276:immunology; D007075:Immunoglobulin M; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D010641:Phenotype; D051381:Rats; D011947:Receptors, Antigen, B-Cell; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000032:analysis* / Q000145:classification / Q000276:immunology; D018800:Thy-1 Antigens; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell; D018800:Thy-1 Antigens; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7