Effect of cimetidine on the pharmacokinetics of the new beta-blocker betaxolol.
The effect of cimetidine on the new beta-blocker betaxolol (Kerlone) was investigated in 7 healthy volunteers. Propranolol was used as a reference beta-blocking drug. In the control study, a single oral dose of propranolol (80 mg) was given (D0) followed by 5 daily doses of cimetidine (1 g) (D1-D6) and a second oral dose of propranolol (D7). The study was repeated with 20 mg of betaxolol replacing the propranolol dose. The oral clearance of propranolol was significantly decreased (21%). No significant effect of cimetidine on the kinetics of betaxolol was observed.
D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics*; D000328:Adult; D015784:Betaxolol; D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D011412:Propanolamines / Q000493:pharmacokinetics*; D011433:Propranolol / Q000493:pharmacokinetics
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D002927:Cimetidine; D011433:Propranolol; D015784:Betaxolol