Fenfluramine antagonizes the stimulation of food intake induced by the putative 5-hydroxytryptamine1A agonist, isapirone, in non-fasted rats.
Isapirone, a 5-hydroxytryptamine1A receptor agonist, stimulated food intake in non-fasted rats in a dose-dependent manner (1, 3 and 10 mg kg-1 s.c.). Fenfluramine, an antiobesity agent and a 5-HT releaser, at 3 and 10 mg kg-1 s.c. antagonized the isapirone-induced (3 mg kg-1 s.c.) feeding. These results are consistent with the known inhibitory role of 5-HT in the control of food intake in rats.
D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D004435:Eating / Q000187:drug effects*; D005277:Fenfluramine / Q000494:pharmacology*; D008297:Male; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*
D011743:Pyrimidines; D011985:Receptors, Serotonin; D005277:Fenfluramine; C043077:ipsapirone; D000420:Albuterol