Excitatory amino acid antagonists depress acoustic startle after infusion into the ventral nucleus of the lateral lemniscus or paralemniscal zone.
Rats were implanted with bilateral cannulas in an area just medial to the ventral nucleus of the lateral lemniscus, an obligatory relay along the acoustic startle pathway. Bilateral infusions of excitatory amino acid transmitter antagonists into this region (10, 25 or 50 nmol per side) produced a rapid, dose-dependent depression of acoustic startle. gamma-D-Glutamylglycine, gamma-D-glutamylaminomethyl sulfonate and 2-amino-5-phosphonovalerate were equally effective in depressing the startle response over this dose range. These results indicate that excitatory amino acid transmitters play an important role in the expression of acoustic startle at this part of the startle pathway.
D015763:2-Amino-5-phosphonovalerate; D000161:Acoustic Stimulation; D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005971:Glutamates / Q000494:pharmacology*; D005973:Glutamine / Q000031:analogs & derivatives*; D006309:Hearing; D008297:Male; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D013216:Reflex, Startle / Q000187:drug effects*; D014633:Valine / Q000031:analogs & derivatives* / Q000494:pharmacology
D004151:Dipeptides; D005971:Glutamates; D018377:Neurotransmitter Agents; D005973:Glutamine; C028929:gamma-glutamylglycine; D015763:2-Amino-5-phosphonovalerate; C042626:gamma-glutamylaminomethylsulfonic acid; D014633:Valine