title: Metabolism of exogenous androgens in rams and wethers: differential clearance rates.
abstract: The effect of the presence of the testes on the clearance rates of 5 and 50 mg of testosterone and androstenedione was examined in 8-month old rams and wethers. Castration did not affect (P greater than 0.10) the clearance of androstenedione or testosterone at the 5 mg dosage. Castration had an effect (P less than 0.05) on the clearance of 50 mg of androstenedione and testosterone. These data indicate that reproductive status has a differential effect on the metabolism of exogenously administered steroids.
mesh_terms: D000735:Androstenedione / Q000097:blood*; D000818:Animals; D008297:Male; D008657:Metabolic Clearance Rate; D009919:Orchiectomy; D012756:Sheep / Q000097:blood*; D013737:Testis / Q000502:physiology*; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone; D000735:Androstenedione