Effect of circulating somatostatin on exocrine pancreatic secretion in conscious dogs.
We determined the effects of exogenous somatostatin-14 (100 and 200 ng/kg/h; mimicking postprandial somatostatin concentrations) on pancreatic responses to a background infusion of secretion in combination with graded doses of CCK-8 in conscious dogs with chronic gastric and duodenal fistulas. The lower dose of somatostatin-14 (S-14), which produced S-14 plasma levels lower than measured after a meal, did not change basal or stimulated pancreatic secretion. The upper dose of S-14, which produced plasma S-14 concentrations slightly above the postprandial range, caused inhibition of pancreatic fluid and protein secretion to low doses of CCK-8 (p less than 0.05). The inhibition was surmountable with higher doses of CCK-8. We interpret these data as indicating that circulating S-14 is not an important hormonal regulator of exocrine pancreatic secretion.
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D004285:Dogs; D010179:Pancreas / Q000378:metabolism*; D010189:Pancreatic Juice / Q000032:analysis / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011863:Radioimmunoassay; D012107:Research Design; D012844:Sincalide / Q000494:pharmacology; D013004:Somatostatin / Q000097:blood / Q000494:pharmacology / Q000502:physiology*
D001639:Bicarbonates; D011506:Proteins; D013004:Somatostatin; D012844:Sincalide