title: Induction of gamma-glutamyltranspeptidase-positive foci in rat liver by deoxycholic acid.
abstract: Initiating activities of the secondary bile acids, deoxycholic acid (DCA) and lithocholic acid (LCA), were examined in terms of the induction of gamma-glutamyltranspeptidase (GGT)-positive foci in rat liver. A rapid induction model of enzyme-altered foci was utilized. GGT-positive foci were clearly induced by DCA ranging from 0.05% to 0.5% in the diet. In contrast, the induction of GGT-positive foci by LCA was less pronounced and was not dose-dependent. These results suggest that DCA possesses initiating activity.
mesh_terms: D000818:Animals; D003840:Deoxycholic Acid / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D008095:Lithocholic Acid / Q000633:toxicity; D008099:Liver / Q000201:enzymology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008297:Male; D011230:Precancerous Conditions / Q000139:chemically induced*; D051381:Rats; D011916:Rats, Inbred F344; D005723:gamma-Glutamyltransferase / Q000032:analysis*
chemical_list: D003840:Deoxycholic Acid; D008095:Lithocholic Acid; D005723:gamma-Glutamyltransferase