[Regulatory subpopulations of T-lymphocytes and blocking factors in the serum of patients with inoperable lung cancer treated with indomethacin].
A considerable disturbance in the ratio of the immunoregulatory T-lymphocyte subpopulations detected by receptors to Fc-fragment of IgM, IgG and by theophilline was revealed in 70 patients with inoperable lung cancer as well as a considerable increase in the blocking circulating immunocomplexes (CIC) in blood serum of these patients. A single dose of indometacin (100 mg/kg) led to the reduction of immunoregulatory disbalance 3 hours after injection and to a decrease in the blocking CIC in blood serum. These data permit recommending the use of indometacin in the treatment of inoperable lung cancer patients.
D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000032:analysis; D001667:Binding, Competitive; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology* / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000188:drug therapy / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification / Q000187:drug effects / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D007213:Indomethacin
Reguliatornye subpopuliatsii T-limfotsitov i blokiruiushchie faktory syvorotki krovi neoperabel'nykh bol'nykh rakom legkogo pri primenenii indometatsina.