Postoperative positive nitrogen balance with intravenous hyponutrition and growth hormone.
11 patients having major gastrointestinal surgery were allocated at random to receive either biosynthetic human growth hormone (BSHGH) 0.1 mg/kg or placebo daily for the first 7 postoperative days. All patients received the same intravenous feeding regimen, which contained 2.09 MJ glucose, 1.88 MJ fat, and 7 g N daily. Patients receiving BSHGH were in positive nitrogen balance throughout the study (mean 1.8 [SEM 0.4] g N/day) and those receiving placebo were in negative nitrogen balance (mean -0.9 [0.7] g N/day). Resting energy expenditure progressively increased in the patients receiving BSHGH (115.7% [14.8] on day 7) but remained unchanged in patients receiving placebo (99.35% [1.4]). Fat oxidation was nearly three times higher in the patients on BSHGH (4.09 [0.38] MJ/day) than in controls (1.38 [0.50]). Carbohydrate oxidation remained about the same in both groups. Whole-body protein turnover, synthesis, and breakdown were increased in the patients receiving growth hormone.
D000368:Aged; D004734:Energy Metabolism; D005767:Gastrointestinal Diseases / Q000601:surgery*; D013006:Growth Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006728:Hormones / Q000008:administration & dosage*; D019382:Human Growth Hormone; D006801:Humans; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism*; D010288:Parenteral Nutrition; D011182:Postoperative Care; D011994:Recombinant Proteins / Q000008:administration & dosage
D006728:Hormones; D011994:Recombinant Proteins; D019382:Human Growth Hormone; D013006:Growth Hormone; D009584:Nitrogen