[Effect of antidepressants on reverse neuromediator uptake by the synaptosomes in control and stressed rats].
The influence of chemically different antidepressants on the uptake of 5-HT, dopamine and GABA by the rat brain synaptosomes was tested, using radioisotope technique in control and chronically stressed (14 days) animals. Drugs were more potent inhibitors of neurotransmitter uptake in synaptosomes of stressed animals, as compared to synaptosomes from control ones, the activity increasing proportionally to the changes in a particular uptake system. It is suggested that the drugs inhibit the uptake of neurotransmitters studied by changing the properties of synaptosomal membrane lipid bilayer. It is also evident that neurochemical properties of psychotropic drugs must be evaluated on the membranes from animals in the model of experimental psychopathology.
D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002908:Chronic Disease; D004353:Drug Evaluation, Preclinical; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D013315:Stress, Psychological / Q000188:drug therapy* / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism; D014316:Tritium
D000928:Antidepressive Agents; D018377:Neurotransmitter Agents; D014316:Tritium
Vliianie antidepressantov na obratnyĭ zakhvat neĭromediatorov sinaptosomami kontrol'nykh i stressirovannykh krys.