title: [Electron microscopic study of the interaction of cultures of Bordetella pertussis altered by antibiotic action with a human amniotic cell culture].
abstract: The adhesive properties of B. pertussis subjected to long-term subcultivation on nutrient media with antibiotics were studied with electron microscopy and it was shown that under the action of erythromycin the adhesive capacity of B. pertussis markedly decreased. Subcultivation on media with tetracycline did not lower the adhesive activity of B. pertussis. Changes in the adhesive properties of B. pertussis under the action of the antibiotics correlated with changes in toxicity, serovars and ultrastructure of the bacteria in the population.
mesh_terms: D000650:Amnion / Q000382:microbiology* / Q000648:ultrastructure; D001422:Bacterial Adhesion / Q000187:drug effects; D001886:Bordetella pertussis / Q000187:drug effects / Q000472:pathogenicity* / Q000648:ultrastructure; D002478:Cells, Cultured; D004848:Epithelium / Q000382:microbiology / Q000648:ultrastructure; D004917:Erythromycin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D013752:Tetracycline / Q000494:pharmacology*
chemical_list: D004917:Erythromycin; D013752:Tetracycline
vernacular_title: Elektronno-mikroskopicheskoe izuchenie vzaimodeĭstviia kul'tur Bordetella pertussis, izmenennykh pod deĭstviem antibiotikov, s kul'turoĭ kletok amniona cheloveka.