title: Observations on multiple drug resistance in coagulase-negative staphylococci isolated in hospitals from 1975 to 1985.
abstract: Drug resistance in coagulase-negative staphylococci (CNS) isolated in hospitals since 1975 was analysed using routine laboratory data registered on a microcomputer. Resistance increased substantially in CNS during the years, especially in Staphylococcus epidermidis isolates, of which more than 50% were multiply drug resistant by 1985. Among the methicillin-resistant CNS strains, resistance to gentamicin rose from 0% in 1975 to 76% in 1985. Co-resistance to kanamycin, gentamicin, and in some cases netilmicin seemed to replace co-resistance to kanamycin and streptomycin in S. epidermidis. Gentamicin and netilmicin usage in hospital increased tenfold from 1976 to 1985.
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D003030:Coagulase / Q000378:metabolism*; D003428:Cross Infection / Q000209:etiology*; D003430:Cross-Sectional Studies; D003718:Denmark; D004352:Drug Resistance, Microbial; D006784:Hospitals, Teaching; D006785:Hospitals, University; D006801:Humans; D010406:Penicillins / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000382:microbiology; D013210:Staphylococcus / Q000201:enzymology* / Q000302:isolation & purification; D013212:Staphylococcus epidermidis; D013754:Tetracyclines / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003030:Coagulase; D010406:Penicillins; D013754:Tetracyclines; D002701:Chloramphenicol