Dopaminergic antagonists potentiate the adenohypophyseal growth reaction to oestrogen: thioridazine is less effective than perphenazine.
The injection of oestradiol benzoate as an aqueous microcrystal suspension, in a dose of 1 mg twice a week, evokes a marked adenohypophyseal growth reaction in male rats. The reaction is potentiated by dopaminergic antagonists from the group of neuroleptics (specifically perphenazine and thioridazine). Elicitation of the same adenohypophyseal reaction required twice as much thioridazine (10 mg/rat per day) as perphenazine. Thyroxine inhibited the adenohypophyseal growth reaction to oestradiol. The serum polyphenol oxidase (ceruloplasmin) level rose after oestradiol and perphenazine and thioridazine slightly potentiated the increase.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D018492:Dopamine Antagonists; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004958:Estradiol / Q000494:pharmacology*; D008297:Male; D010546:Perphenazine / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000254:growth & development*; D051381:Rats; D011919:Rats, Inbred Strains; D013881:Thioridazine / Q000494:pharmacology*
D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D004958:Estradiol; D010546:Perphenazine; D013881:Thioridazine