title: Expression of cyclin (PCNA) and the phosphoprotein dividin are late obligatory events in the mitogenic response.
abstract: Analysis of the overall patterns of gene expression at the polypeptide synthesis level has revealed two S-phase specific, proliferation sensitive nuclear proteins [cyclin (PCNA) and dividin (phosphoprotein)] whose rate of synthesis increases at the G1/S transition border of the cell cycle. All available evidence suggests that expression of these proteins are late obligatory events in the mitogenic response.
mesh_terms: D002453:Cell Cycle; D002471:Cell Transformation, Neoplastic; D004261:DNA Replication; D006367:HeLa Cells; D006801:Humans; D007526:Isoelectric Point; D008970:Molecular Weight; D009687:Nuclear Proteins / Q000502:physiology*; D010750:Phosphoproteins / Q000502:physiology*; D018809:Proliferating Cell Nuclear Antigen
chemical_list: D009687:Nuclear Proteins; D010750:Phosphoproteins; D018809:Proliferating Cell Nuclear Antigen