Efficacy of amoxicillin trihydrate for the treatment of experimentally induced foot rot in cattle.
Twenty holstein heifers were intradermally inoculated in the interdigital skin with a suspension containing Fusobacterium necrophorum and Bacteroides melaninogenicus to induce acute foot rot. Lesions, lameness, and swelling were evaluated during the study, using a subjective scoring system. Rectal temperature, species and number of bacteria isolated, and change in body weight were monitored throughout the study. Ten heifers (treated) were given amoxicillin trihydrate (10 mg/kg of body weight, IM) for 5 days, beginning at the onset of lameness. The remaining 10 heifers (controls) were given physiologic saline solution IM. Treated heifers had less severe lesions and greater weight gain than did control heifers. Rectal temperatures of treated heifers did not differ significantly from those of control heifers. It was concluded that administration of amoxicillin trihydrate early in the course of acute foot rot may reduce the severity of lesions associated with foot rot in cattle.
D000658:Amoxicillin / Q000627:therapeutic use*; D000818:Animals; D001442:Bacteroides Infections / Q000188:drug therapy / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005260:Female; D005535:Foot Rot / Q000188:drug therapy*; D005674:Fusobacterium Infections / Q000188:drug therapy / Q000662:veterinary*; D005675:Fusobacterium necrophorum; D001443:Prevotella melaninogenica
D000658:Amoxicillin