A simple and rapid high-pressure liquid chromatographic assay for pentobarbital and other barbiturates in serum.
A single extraction technique for measuring pentobarbital and other barbiturates in serum involved high-pressure liquid chromatography and UV detection yielding a sensitivity for pentobarbital of about 1 microgram/ml. We concluded that the assay provides a practical method for use in pharmacokinetic studies and in serum concentration monitoring in experimental animals.
D000818:Animals; D001463:Barbiturates / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D006591:Hexobarbital / Q000097:blood; D066298:In Vitro Techniques; D010424:Pentobarbital / Q000097:blood; D010634:Phenobarbital / Q000097:blood; D011817:Rabbits
D001463:Barbiturates; D006591:Hexobarbital; D010424:Pentobarbital; D010634:Phenobarbital