Inhibition of N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release by phencyclidine is dependent on potassium concentration.
This study examined the ability of phencyclidine (PCP) to inhibit the responses to N-methyl-D-aspartate (NMDA) in depolarizing concentrations of K+. The effects of PCP and Mg2+ on NMDA-induced norepinephrine release from hippocampal slices were measured during superfusion with various extracellular concentrations of K+. The IC50 values for Mg2+ and PCP were significantly higher in K+ concentrations above 6 mM. These data are supportive of the hypothesis that PCP produces a voltage-dependent blockade of NMDA-activated ion channels.
D015763:2-Amino-5-phosphonovalerate; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008278:Magnesium Sulfate / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate; D009638:Norepinephrine / Q000378:metabolism*; D010622:Phencyclidine / Q000494:pharmacology*; D011188:Potassium / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
D001224:Aspartic Acid; D016202:N-Methylaspartate; D008278:Magnesium Sulfate; D015763:2-Amino-5-phosphonovalerate; D014633:Valine; D010622:Phencyclidine; D011188:Potassium; D009638:Norepinephrine