title: Morphine-like analgesics and convulsive threshold for pentetrazole in dogs.
abstract: In dogs, the influence of morphine (1 mg/kg i.m.), fentanyl (10 and 30 micrograms/kg i.v.), meperidine (6 mg/kg i.m.), and pentazocine (3 mg/kg i.m.) on the pentetrazole seizure threshold was studied. Pentetrazole was infused i.v. at a rate of 10 mg/kg per min up to the first generalized myoclonic jerk. The analgesic treatments lowered the seizure threshold considerably in 5 out of 6 dogs, and fentanyl and pentazocine led to an increased incidence of clonic-tonic seizures after the end of the pentetrazole infusion.
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D005260:Female; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine; D010433:Pentylenetetrazole