An RFLP for glycoprotein A (MN) is in linkage disequilibrium with MN and Ss.
Using a cDNA for glycophorin A (MN), we screened 10 unrelated Caucasians using 22 restriction enzymes for RFLPs. A common StuI RFLP was identified and shown to be in marked linkage disequilibrium with both the MN and Ss blood-group antigens in a larger group of unrelated Caucasians. This provides a DNA marker for a locus that has been of major importance in genetic and population studies. The demonstrated disequilibrium will prove useful in localizing the gene for glycophorin B and in studies of genetic and physical distances on human chromosomes.
D004247:DNA / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D006021:Glycophorins / Q000235:genetics*; D006801:Humans; D008951:MNSs Blood-Group System / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012795:Sialoglycoproteins / Q000235:genetics*
D005819:Genetic Markers; D006021:Glycophorins; D008951:MNSs Blood-Group System; D012795:Sialoglycoproteins; D004247:DNA