Measles virus-induced mononuclear leukocyte adherence inhibition: effect of some drugs influencing arachidonic acid metabolic pathways.
Effect of some drugs influencing arachidonic acid metabolic pathways upon the measles virus-induced leukocyte adherence inhibition was investigated in multiple sclerosis patients and in the control group. The drugs used were natrium salicylate, ethanol, and phenidon(1-phenyl-3-pyrazolidon). Statistically significant differences were proved between multiple sclerosis patients and controls using phenidon, a drug inhibiting both cyclooxygenase and lipoxygenase pathways of the arachidonic acid metabolism. The results obtained provide suggestion on participation of arachidonic acid metabolism in the measles virus-induced leukocyte adherence inhibition phenomenon and in its alterations in multiple sclerosis.
D000328:Adult; D001095:Arachidonic Acids / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007957:Leukocyte Adherence Inhibition Test; D008297:Male; D008459:Measles virus / Q000276:immunology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology* / Q000378:metabolism; D011720:Pyrazoles / Q000494:pharmacology*; D012980:Sodium Salicylate / Q000494:pharmacology*
D001095:Arachidonic Acids; D011720:Pyrazoles; D000431:Ethanol; C015429:phenidone; D012980:Sodium Salicylate