title: Adduct formation between soluble fibrin monomers and elastin.
abstract: Monomers of fibrin generated from fibrinogen by thrombin reacted with elastin to give a new addition product or adduct. The adduct formation results from a covalent bond between both proteins, formation of which is dependent on elastin, fibrinogen and Ca2+ concentrations; but, Factor XIIIa did not intervene. Addition of fibronectin, together with fibrinogen, as cold insoluble proteins from human plasma, and of soluble collagen from rat tail tendon did not inhibit the first reaction. This enabled us to elaborate a new artificial connective matrix.
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002417:Cattle; D003094:Collagen / Q000494:pharmacology; D003450:Cryoglobulins / Q000494:pharmacology; D004549:Elastin / Q000378:metabolism*; D005176:Factor XIII / Q000378:metabolism; D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism; D005353:Fibronectins / Q000494:pharmacology; D006801:Humans; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D012995:Solubility; D011503:Transglutaminases
chemical_list: D003450:Cryoglobulins; D005353:Fibronectins; D005337:Fibrin; D005340:Fibrinogen; D003094:Collagen; D004549:Elastin; D005176:Factor XIII; D011503:Transglutaminases; D002118:Calcium