title: Overuse syndrome: a muscle biopsy study.
abstract: Biopsy specimens were taken from the affected first dorsal interosseous muscle in 29 women with painful chronic overuse syndrome and from 8 volunteer controls. Structural differences in samples from the women with overuse syndrome included increased type 1 fibres with type grouping, decreased type 2 fibres, type 2 fibre hypertrophy, increased internal nuclear count, mitochondrial changes, and various ultrastructural abnormalities. These changes were related to clinical severity, and point to an organic cause for the syndrome.
mesh_terms: D000328:Adult; D001706:Biopsy / Q000379:methods; D002908:Chronic Disease; D012090:Cumulative Trauma Disorders / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006225:Hand; D006652:Histological Techniques; D006801:Humans; D008854:Microscopy, Electron; D008931:Mitochondria, Muscle / Q000473:pathology / Q000648:ultrastructure; D009132:Muscles / Q000473:pathology* / Q000648:ultrastructure; D009784:Occupational Diseases / Q000473:pathology*