[Determination of enzyme activities in urine of patients with calcium oxalate calculi].
The catalytic activity of lactate dehydrogenase, gamma-glutamyltransferase, alkaline phosphatase, alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase has been measured in 24 h urines of patients with a calcium oxalate calculus (9 men, 11 women) and has been compared with those of a reference collective (11 men, 10 women). The diagnostic sensitivity and the diagnostic specificity have been calculated according to four different discrimination methods in which the diagnostic sensitivity lies between 65% and 100%, the diagnostic specificity between 72% and 100%. Within the reference group there was a correlation between the excretion of the three brush-border enzymes, whereas within the group of patients only a correlation between gamma-glutamyltransferase and N-acetyl-beta-D-glucosaminidase was observed. From this pathophysiological conclusions can be drawn.
D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000652:urine; D000626:Aminopeptidases / Q000652:urine; D018826:CD13 Antigens; D002129:Calcium Oxalate / Q000032:analysis; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000652:urine; D008297:Male; D008871:Microvilli / Q000201:enzymology; D008875:Middle Aged; D014545:Urinary Calculi / Q000032:analysis / Q000201:enzymology* / Q000652:urine; D005723:gamma-Glutamyltransferase / Q000652:urine
D002129:Calcium Oxalate; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D000118:Acetylglucosaminidase; D000626:Aminopeptidases; D018826:CD13 Antigens
Bestimmung von Enzymaktivitäten in Urinen von Calciumoxalatstein-Patienten.