title: [Biotransformation and pharmacokinetics of bamipine in rats. 2. Studies of the pharmacokinetics (1.)].
abstract: Biotransformation and Pharmacokinetics of Bamipine in Rats/2nd Communication: Pharmacokinetic studies (Part I). After oral application in Wistar rats the pharmacokinetic properties of N-phenyl-N-benzyl-4-amino-1-methylpiperidine (bamipine) were investigated. The compound is quantitatively absorbed. Bamipine distribution occurs in the whole organism. A transient accumulation was found in liver, kidney, spleen and lung. The compound's liquor patency was established. The elimination is mainly renal (85.81%), 13.23% are eliminated by feces. The total excretion after 96 h is more than 99%.
mesh_terms: D000818:Animals; D004334:Drug Administration Schedule; D006634:Histamine H1 Antagonists / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D010880:Piperidines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D006634:Histamine H1 Antagonists; D010880:Piperidines; C020867:bamipine
vernacular_title: Biotransformation und Pharmakokinetik von Bamipin an Ratten. 2. Mitteilung: Untersuchungen zur Pharmakokinetik (1. Teil).