title: Double-blind comparison of captopril alone against frusemide plus amiloride in mild heart failure.
abstract: Captopril alone as therapy for mild heart failure was compared with a combination of frusemide and amiloride in a double-blind randomised crossover trial in 14 patients who had previously been treated with diuretics. Although 10 patients remained stable on captopril alone, 4 patients deteriorated, with the development of pulmonary oedema of breathlessness. All 4 patients had had pulmonary oedema previously, unlike the patients who remained stable. Angiotensin converting enzyme inhibition alone is not sufficient treatment for patients with mild heart failure and a history of overt pulmonary oedema.
mesh_terms: D000584:Amiloride / Q000008:administration & dosage*; D002216:Captopril / Q000008:administration & dosage*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000008:administration & dosage; D004311:Double-Blind Method; D004338:Drug Combinations / Q000008:administration & dosage; D005080:Exercise Test; D005260:Female; D005665:Furosemide / Q000008:administration & dosage*; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation
chemical_list: D004232:Diuretics; D004338:Drug Combinations; D000584:Amiloride; D005665:Furosemide; C046878:frumil; D002216:Captopril