Overexpression of the c-erbB-2 oncoprotein in human breast carcinomas: immunohistological assessment correlates with gene amplification.
Amplification of the human protooncogene c-erbB-2 was found in 12 of 36 human breast tumours and was associated with increased levels of expression of the c-erbB-2 protein, measured both by immunohistological staining and by western blotting. The use of immunohistological staining to detect the level of expression of the c-erbB-2 protein in human breast adenocarcinomas may be of value in predicting tumour behaviour.
D000230:Adenocarcinoma / Q000032:analysis* / Q000235:genetics; D001943:Breast Neoplasms / Q000032:analysis* / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D006801:Humans; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000032:analysis*
D011518:Proto-Oncogene Proteins