Phospholipidic second messengers and calcium.
A number of signal molecules bind to surface receptors of target cells and generate intracellular messengers from inositol-containing phospholipids. The phosphatidyl inositol (4, 5) bisphosphate is hydrolyzed into inositol (1, 4, 5) trisphosphate and diacylglycerol. These messengers, via changes in the concentrations of cytosolic Ca2+ and H+ and/or protein phosphorylations, couple the signal to a variety of responses including activation of metabolism, secretion, aggregation, phototransduction, cell proliferation and possibly contraction.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002450:Cell Communication; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology*; D010716:Phosphatidylinositols / Q000502:physiology*
D018377:Neurotransmitter Agents; D010716:Phosphatidylinositols; D002118:Calcium