Immunohistochemical detection of proliferating cell nuclear antigen in solid human malignancies.
Proliferating cell nuclear antigen (PCNA), also known as cyclin, is a cell cycle-related nuclear protein that is maximally elevated in late G1 and S phases of proliferating cells. In this study, PCNA was identified by paraffin-section immunohistochemistry in 42 of 64 solid human malignancies, and in several benign tissues known to contain proliferating cells. The PCNA-positive nuclei were randomly distributed and ranged from less than 1% (in most cases) to more than 20% of the neoplastic cells. In general, PCNA positivity correlated with mitotic activity and tumor grade. Further study is necessary to evaluate PCNA as a marker of cellular proliferation and a potential prognostic marker in human malignancy.
D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D009369:Neoplasms / Q000032:analysis*; D009698:Nucleoproteins / Q000032:analysis*; D018809:Proliferating Cell Nuclear Antigen
D009698:Nucleoproteins; D018809:Proliferating Cell Nuclear Antigen