Effect of neurotensin on the smooth muscle of the chicken crop.
1. The effect of neurotensin was studied in the isolated smooth muscle of the chicken crop. 2. This peptide induced concentration-dependent (10(-10)-10(-8) mol/l) contractions of muscle strips. 3. The response to neurotensin was not modified after incubation of the preparation with atropine, indomethacin, naloxone and tetrodotoxin. The neurotensin-exerted contractions are therefore probably myogenic. 4. These properties of neurotensin indicate a possible role for this peptide in the control of crop motility.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D007213:Indomethacin / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D009496:Neurotensin / Q000494:pharmacology*; D013779:Tetrodotoxin / Q000494:pharmacology
D009270:Naloxone; D009496:Neurotensin; D013779:Tetrodotoxin; D001285:Atropine; D007213:Indomethacin