Alpha-adrenoceptor blocking action of hymenin, a novel marine alkaloid.
In the rabbit isolated aorta, hymenin (10(-6) M), a novel marine alkaloid, caused a parallel rightward shift of the dose-response curve for norepinephrine without affecting that for histamine or KCl, suggesting that hymenin is a competitive antagonist of alpha-adrenoceptors in vascular smooth muscles.
D000317:Adrenergic alpha-Antagonists; D000818:Animals; D001011:Aorta; D001794:Blood Pressure / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000502:physiology; D012717:Sesquiterpenes / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D011942:Receptors, Adrenergic, alpha; D012717:Sesquiterpenes; D011189:Potassium Chloride; D006632:Histamine; C022097:parthenin; D009638:Norepinephrine