Paradoxical deterioration in lung function after nebulised salbutamol in wheezy infants.
In 13 infants with a history of wheezing, airways resistance and specific conductance worsened after administration of nebulised salbutamol (0.5 ml sabutamol respirator solution in 1.5 ml normal saline). This paradoxical bronchoconstriction was greatest at 5 min and lasted for up to 15 min. The nebulised solution was found to be acidic and hypo-osmolar, both of which properties have been linked to bronchoconstriction in asthmatic subjects, but even with an initially iso-osmolar solution osmolality increased with time of nebulisation because of evaporation.
D000336:Aerosols; D000403:Airway Resistance / Q000187:drug effects; D000420:Albuterol / Q000008:administration & dosage / Q000009:adverse effects*; D001980:Bronchi / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D008297:Male; D009994:Osmolar Concentration; D012135:Respiratory Sounds / Q000188:drug therapy*; D013997:Time Factors
D000336:Aerosols; D000420:Albuterol