Gastric acid secretory responses to cholinergic and histaminergic stimulation in chronic morphine-treated rats.
The effects of chronic morphine administration on cholinergic and histaminergic activities were evaluated in rats by observing their gastric acid secretory responses to secretagogues. The responses of in-vivo perfused stomachs to 2-deoxy-D-glucose or pentagastrin, and of the isolated gastric mucosa to histamine or bethanechol, were not significantly different between naive and chronic morphine-treated animals. It is suggested that the chronic morphine-treated rats exhibit normal cholinergic and histaminergic activities as well as receptor sensitivities to acetylcholine and histamine.
D000818:Animals; D018723:Bethanechol; D001626:Bethanechol Compounds; D002799:Cholinergic Fibers / Q000502:physiology; D003847:Deoxyglucose; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006632:Histamine; D008297:Male; D009021:Morphine Dependence / Q000503:physiopathology*; D010418:Pentagastrin; D051381:Rats; D011919:Rats, Inbred Strains; D011970:Receptors, Histamine H2 / Q000502:physiology
D001626:Bethanechol Compounds; D011970:Receptors, Histamine H2; D018723:Bethanechol; D006632:Histamine; D003847:Deoxyglucose; D010418:Pentagastrin