[Multi-indicator biochemical and clinical evaluation of occupational exposure of workers in the petrochemical industry. II. Results of the search for early clinico-biochemical signs of exposure to toxic substances present in the petrochemical industry. Analysis of the results of 5-year epidemiological studies].
The activities of GGT (EC 2.3.2.1.) and glycine transaminidase (EC 2.6.2.1.) increased in all studied groups after at minimum four years of exposure to: acetobenzene, furfurol, ethylene--derivatives, polypropylene and butadiene. Besides these universal indicators the specific ones were found for a particular group of exposure: for acetobenzene--sialic acid, haptoglobine and IgA, for furfurol--sialic acid and haptoglobine, for ethylene--derivatives--haptoglobine, ceruloplasmine and the activity of arginase of the red blood cells, for polypropylene--IgA, for butadiene--proteolytic activity. These changes are treated as a manifestation of adaptive processes--the answer of the body to the environmental stimuli but not as the signs of early damage. The need of verification of the results by prospective studies is stressed.
D000328:Adult; D000579:Amidinotransferases / Q000097:blood; D002617:Chemical Industry; D004796:Clinical Enzyme Tests; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis; D010578:Petroleum / Q000009:adverse effects*; D005723:gamma-Glutamyltransferase / Q000097:blood
D010578:Petroleum; D000579:Amidinotransferases; C020681:glycine amidinotransferase; D005723:gamma-Glutamyltransferase
Wielowskaźnikowa ocena biochemiczno-kliniczna narazenia pracownikówprzemysłu petrochemiczego. Cz. II. Wyniki poszukiwań wczesnych objawów kliniczno-biochemicznych narazenia na toksyczny wpływ substancji wystepujacych w przemyśle petrochemicznym. Analiza wyników 5-letnich badań epidemiologicznych.