Fundic, antral and pancreatic D-cell population changes following oophorectomy and sex hormone administration in guinea pigs. Experimental immunocytochemical study.
Twelve female guinea pigs were given estradiol and another 12 testosterone for 18 days. A third group of 15 animals underwent oophorectomy and a group of 8 animals served as controls. Gastric and pancreatic D-cells were quantitated in all four groups. Oophorectomy and androgens significantly increased and estrogens significantly decreased gastric D-cell populations. Additionally, estrogens significantly decreased D-cell population in pancreatic islets. It is concluded that the alterations in gastric and pancreatic D-cell populations, which are induced by sex hormone administration and oophorectomy, possibly reflect a hormonal adaptive attempt to restore gastric secretory functions within the normal range.
D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D006168:Guinea Pigs; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology; D013004:Somatostatin / Q000378:metabolism; D013739:Testosterone / Q000494:pharmacology
D012739:Gonadal Steroid Hormones; D013739:Testosterone; D004958:Estradiol; D013004:Somatostatin