Influence of cold exposure on liver amino acid metabolism enzymes of the rat.
The activities of alanine, aspartate and branched-chain amino acid transaminases, glutamate dehydrogenase, glutamine synthetase and adenylate deaminase have been studied in liver of male rats exposed [12 hours at 4 degrees C] or acclimated [15 days at 4 degrees C] to cold temperature. Cold temperature induced an increase of the activities of glutamate dehydrogenase and alanine and aspartate transaminases both in cold-exposed and cold-acclimated animals; adenylate deaminase activity diminished after 15-day cold acclimation. There were not significant changes induced by cold temperature in the activities of the other two enzymes studied. These results agree with a possible direct implication of amino acid utilization by the liver in the context of the overall thermogenic response to cold temperature.
D000659:AMP Deaminase / Q000378:metabolism; D000064:Acclimatization; D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000597:Amino Acids, Branched-Chain / Q000378:metabolism; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D003080:Cold Temperature; D051263:D-Alanine Transaminase; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000637:Transaminases / Q000378:metabolism
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D001224:Aspartic Acid; D005969:Glutamate Dehydrogenase; D000637:Transaminases; D051263:D-Alanine Transaminase; D000659:AMP Deaminase; D005974:Glutamate-Ammonia Ligase; D000409:Alanine