The topical anti-inflammatory effects of a topical preparation of meclofenamic acid on carrageenan-induced footpad swelling in mice.
A topical preparation of meclofenamic acid (Meclomen) was tested for anti-inflammatory activity in a murine model of carrageenan footpad oedema. The preparation significantly inhibited swelling when applied to the carrageenan-injected paw. Maximum inhibition was observed 4-5 h after carrageenan injection. The topical effects could not be attributed to systemic absorption because the preparation was more inhibitory when applied topically to the carrageenan-injected paw than to a distant site or orally.
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D007213:Indomethacin / Q000008:administration & dosage; D008469:Meclofenamic Acid / Q000008:administration & dosage*; D051379:Mice; D008810:Mice, Inbred C57BL; D062367:ortho-Aminobenzoates / Q000008:administration & dosage*
D000893:Anti-Inflammatory Agents; D062367:ortho-Aminobenzoates; D008469:Meclofenamic Acid; D002351:Carrageenan; D007213:Indomethacin