title: Excitatory P1-purinoceptors on pre- and post-ganglionic cholinergic nerve terminals in the chick oesophagus.
abstract: The mechanism of action of ATP and the purinoceptors involved have been investigated on the chick oesophagus. The susceptibility of the excitatory responses to ATP/adenosine to tetrodotoxin indicates that their action is neurally mediated. Blockade of ATP/adenosine responses by atropine suggests the involvement of endogenous acetylcholine. ATP action depends on breakdown to AMP/adenosine, since theophylline blocks ATP/adenosine responses. The inhibition of ATP responses by pentolinium implies the involvement of preganglionic fibres.
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002645:Chickens; D004947:Esophagus / Q000294:innervation*; D005260:Female; D008297:Male; D009411:Nerve Endings / Q000187:drug effects*; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011983:Receptors, Purinergic / Q000187:drug effects*; D013779:Tetrodotoxin / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology
chemical_list: D011950:Receptors, Cholinergic; D011983:Receptors, Purinergic; D013779:Tetrodotoxin; D001285:Atropine; D000255:Adenosine Triphosphate; D013806:Theophylline; D000241:Adenosine