Pneumococcal vaccine prevents death from acute lower-respiratory-tract infections in Papua New Guinean children.
In three double-blind placebo-controlled trials of pneumococcal capsular polysaccharide vaccines against death from acute lower-respiratory-tract infections (ALRI), children were vaccinated at 6 months to 5 years of age. The efficacy of the vaccines against ALRI as the sole cause of death was estimated at 59% in children vaccinated when younger than 5 years (p = 0.008) and 50% in children vaccinated when younger than 2 years (p = 0.043). Mortality from all causes was 19% less in the vaccinated group.
D000208:Acute Disease; D001428:Bacterial Vaccines; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D010219:Papua New Guinea; D022242:Pneumococcal Vaccines; D011897:Random Allocation; D012141:Respiratory Tract Infections / Q000401:mortality* / Q000517:prevention & control; D013296:Streptococcus pneumoniae / Q000276:immunology*
D001428:Bacterial Vaccines; D022242:Pneumococcal Vaccines