Pituitary-adrenal mediation of dermorphin-induced inhibition of gastric emptying in rats.
The role of the pituitary-adrenal axis in the inhibition of gastric emptying caused by intracerebroventricular (i.c.v.) administration of dermorphin was examined. Dermorphin given i.c.v. (1, 10, 100 ng per rat) slowed emptying in a dose-related manner. Hypophysectomy or sub-diaphragmatic bivagotomy reduced, and adrenalectomy prevented the inhibition of gastric emptying associated with dermorphin. Dermorphin inhibition of gastric emptying is thus specially dependent upon intact adrenals.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005746:Gastric Emptying / Q000187:drug effects*; D007016:Hypophysectomy; D007276:Injections, Intraventricular; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D010902:Pituitary Gland / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014628:Vagotomy
D000701:Analgesics, Opioid; D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin