Anxiolytic activity of an endogenous adrenal steroid.
The A-ring reduced metabolite of deoxycorticosterone, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) was recently shown to act at the gamma-aminobutyric acid receptor-chloride ion channel complex in rat brain. The behavioral profile of THDOC was investigated using two animal models of anxiety, the two-chambered mouse exploration test and the lick suppression conflict test. THDOC showed anxiolytic activity in both animal models, with an anxiolytic dose range, 5-15 mg/kg i.p., separable from the sedative dose range, above 20-30 mg/kg i.p.
D000818:Animals; D014151:Anti-Anxiety Agents; D003220:Conflict, Psychological; D003900:Desoxycorticosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D051379:Mice
D014151:Anti-Anxiety Agents; D003900:Desoxycorticosterone; C009413:tetrahydrodeoxycorticosterone