Deltamethrin induced changes in choline transport and phosphorylation activities in synaptosomes from the optic lobe of squid, Loligo pealei.
1. Deltamethrin, a powerful synthetic pyrethroid causes a significant change in choline transport in freshly prepared synaptosomes from squid optic lobes. 2. At resting state (nondepolarized) such an effect manifested as a reduction of 14C-choline uptake in a short term (1 min) uptake experiment. 3. At depolarized state, or under conditions where synaptosomes are subjected to osmotic, aging and other stress conditions, deltamethrin caused stimulation of 14C-choline uptake, resulting in elevation of the levels of total radiocarbons in synaptosomes. 4. Such changes are accompanied with changes in overall phosphorylation activities in synaptosomes.
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D002118:Calcium / Q000502:physiology; D002794:Choline / Q000378:metabolism*; D003292:Convulsants / Q000494:pharmacology; D049832:Decapodiformes / Q000378:metabolism*; D006426:Hemicholinium 3 / Q000494:pharmacology; D066298:In Vitro Techniques; D007306:Insecticides / Q000494:pharmacology*; D009570:Nitriles; D010766:Phosphorylation; D011188:Potassium / Q000502:physiology; D011722:Pyrethrins / Q000494:pharmacology*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D013779:Tetrodotoxin / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology; D014701:Veratridine / Q000494:pharmacology
D001570:Benzodiazepinones; D003292:Convulsants; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin; C028513:4'-chlorodiazepam; D006426:Hemicholinium 3; D013779:Tetrodotoxin; D014701:Veratridine; D014700:Verapamil; D002794:Choline; D011188:Potassium; D002118:Calcium