title: The major protein of SAF is absent from spleen and thus not an essential part of the scrapie agent.
abstract: Scrapie-associated fibrils (SAF) play a controversial role in the discussion about the nature of the scrapie agent. In purification experiments SAF can be detected in brains of infected animals but not in spleen samples with similar titers of infectivity. Thus, SAF are not a constituent of the scrapie virus.
mesh_terms: D000818:Animals; D001921:Brain / Q000382:microbiology; D001923:Brain Chemistry; D006224:Cricetinae; D051379:Mice; D009419:Nerve Tissue Proteins / Q000032:analysis*; D018622:PrP 27-30 Protein; D011328:Prions / Q000032:analysis*; D012608:Scrapie / Q000378:metabolism* / Q000382:microbiology; D013154:Spleen / Q000032:analysis* / Q000382:microbiology
chemical_list: D009419:Nerve Tissue Proteins; D011328:Prions; D018622:PrP 27-30 Protein