Confronting cisternae in pituitary gland thyrotrophs of congenitally hypothyroid mice.
Confronting cisternae were found in pituitary thyrotrophs of congenitally hypothyroid mice. These confronting cisternae rapidly reverted back to ordinary rough endoplasmic reticulum following thyroxine administration. Confronting cisternae were not observed in the thyrotrophs of euthyroid control mice. Our results strongly suggest that confronting cisternae are a peculiar form of rough endoplasmic reticulum which appears under certain conditions of enhanced cellular metabolism.
D000818:Animals; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D007037:Hypothyroidism / Q000235:genetics / Q000473:pathology*; D051379:Mice; D008817:Mice, Mutant Strains / Q000033:anatomy & histology; D008854:Microscopy, Electron; D010902:Pituitary Gland / Q000473:pathology*; D013974:Thyroxine / Q000494:pharmacology
D013974:Thyroxine