Postmortem changes in the enzymes of GABA and glutamate metabolism in the cerebellum and forebrain of newborn and adult rats.
Postmortem changes in the activity of GDH, GAD, GABA-T, and GS in the adult forebrain and cerebellum and in the forebrain of newborns have been investigated. The activities of GDH, GAD, and GS were stable till 12 hr after death in both adult and young brain regions studied. The activity of GABA-T was stable till 30 min postmortem, but declined progressively thereafter in both regions in adult, as well as in young forebrain.
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000473:pathology; D002531:Cerebellum / Q000201:enzymology* / Q000473:pathology; D004795:Enzyme Stability; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D005969:Glutamate Dehydrogenase / Q000378:metabolism*; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D011180:Postmortem Changes; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005971:Glutamates; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D005969:Glutamate Dehydrogenase; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase; D005974:Glutamate-Ammonia Ligase