[Enzyme parameters in the evaluation of the combined effects of protein deficiency and T-2 mycotoxin].
Male Wistar rats received a low-protein (4.5% protein) diet during 30 days, and T-2-toxin was administered to them through a gastric tube, in a dose of 0.54 mg/kg, during 15 days. The results obtained showed activation of hepatic lysosomal enzymes (sulfatase A and B aryl and beta-glucosidase) and alkaline phosphatase, and to an essential suppression of enzymatic activity of peroxisomes - catalase, glycolate oxidase and D-amino acid oxidase. A sharp aggravation of the intoxication symptoms and pronounced intensification of changes in enzymatic activity in the liver, spleen, thymus and blood serum were recorded in the animals given T-2 toxin simultaneously with the low-protein diet.
D000118:Acetylglucosaminidase / Q000032:analysis; D000429:Alcohol Oxidoreductases / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D001192:Arylsulfatases / Q000032:analysis; D002374:Catalase / Q000032:analysis; D003605:D-Amino-Acid Oxidase / Q000032:analysis; D008099:Liver / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D011488:Protein Deficiency / Q000150:complications / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes / Q000506:poisoning*; D013154:Spleen / Q000201:enzymology; D013605:T-2 Toxin / Q000506:poisoning*; D013950:Thymus Gland / Q000201:enzymology; D001617:beta-Glucosidase / Q000032:analysis
D012717:Sesquiterpenes; D000429:Alcohol Oxidoreductases; C020821:glycollate oxidase; D002374:Catalase; D003605:D-Amino-Acid Oxidase; D000469:Alkaline Phosphatase; D001192:Arylsulfatases; D001617:beta-Glucosidase; D000118:Acetylglucosaminidase; D013605:T-2 Toxin
Enzimologicheskie pokazateli pri otsenke kombinirovannogo vozdeĭstviia belkovoĭ nedostatochnosti i T-2 mikotoksina.