Alzheimer's disease: coated vesicles, coated pits and the amyloid-related cell.
The amyloid-related cell (ARC) of the neuritic plaques of Alzheimer's disease revealed numerous cytoplasmic projections surrounding extracellular amyloid material. It is proposed that ARC-coated vesicles fuse with the cell membrane, forming coated pits, which may empty their secretory material into the extracellular space where polymerization of amyloid filaments could occur.
D000544:Alzheimer Disease / Q000473:pathology*; D000682:Amyloid / Q000032:analysis*; D002462:Cell Membrane / Q000648:ultrastructure; D003034:Coated Pits, Cell-Membrane / Q000648:ultrastructure*; D011992:Endosomes / Q000648:ultrastructure*; D005260:Female; D005625:Frontal Lobe / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged
D000682:Amyloid