[Adult T-cell leukemia associated with HTLV1 and positive HIV2 serology in an African woman].
We report a case of acute adult T-cell leukemia associated with HTLV1 infection in a young African woman. The leukemic proliferation consisted of CD4-, CD25-positive lymphoid cells with typically convoluted nuclei and monoclonal integration of the HTLV1-proviral DNA. The clinical course was characterized by a rapid progression of the leukemia with development of hypercalcemia, resistance to chemotherapy, and the presence of multiple opportunistic infections. The additional finding of a seropositivity for HIV2 raises the problem of the respective contribution of the two retroviruses in this patient's disease.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000382:microbiology; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D004279:DNA, Viral / Q000032:analysis; D017977:Deltaretrovirus / Q000235:genetics; D006800:Deltaretrovirus Infections / Q000150:complications* / Q000382:microbiology; D005260:Female; D015483:HIV Antibodies; D006679:HIV Seropositivity; D006801:Humans; D009894:Opportunistic Infections
D000914:Antibodies, Viral; D004279:DNA, Viral; D015483:HIV Antibodies
Leucémie T de l'adulte associée au virus HTLV1 et à une sérologie positive pour le VIH2 chez une Africaine.