Effects of adrenalectomy before weaning and short- or long-term glucocorticoid administration on the genetically obese Zucker rat.
Intact obese rats were hyperinsulinaemic, had higher rates of whole-body fatty acid synthesis, higher activities of hepatic acetyl-CoA carboxylase and tyrosine aminotransferase and a higher hepatic glycogen concentration than intact lean animals. Adrenalectomy abolished all these factors of the obese phenotype. Treatment of adrenalectomized rats with corticosterone for 24 h increased the rate of whole-body fatty acid synthesis to the same extent in both phenotypes, but caused a larger increase in glycogen concentration, tyrosine aminotransferase activity and plasma insulin concentration in obese rats.
D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000315:Adrenalectomy; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003345:Corticosterone / Q000008:administration & dosage / Q000494:pharmacology*; D005227:Fatty Acids / Q000096:biosynthesis; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000378:metabolism*; D051381:Rats; D011924:Rats, Zucker; D014444:Tyrosine Transaminase / Q000378:metabolism; D014886:Weaning
D001786:Blood Glucose; D005227:Fatty Acids; D007328:Insulin; D008112:Liver Glycogen; D014444:Tyrosine Transaminase; D000103:Acetyl-CoA Carboxylase; D003345:Corticosterone