[Paradoxical correlations of the effectiveness of the intranasal and intraperitoneal administration of dermorphins in rats].
The analgetic activity of dermorphin and its analogue A-2 was assessed by the tail-flick test. Following intraperitoneal administration at doses 5 mg/kg and above the peptides showed significant effects. After intranasal application of the peptides a significant effect was observed in the range of low doses 0.001-0.1 mg/kg. After intranasal application of high dermorphin doses (1 or 5 mg/kg) the analgetic activity decreased. The effect of analogue A-2 lasted longer after intranasal, than after intraperitoneal administration. It is assumed that the neurophysiological mechanisms of the analgetic activity of dermorphins depend on the route of their administration.
D000281:Administration, Intranasal; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage*; D018847:Opioid Peptides; D010147:Pain Measurement; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D000701:Analgesics, Opioid; D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin; C045484:dermorphin, Arg(2)-
Paradoksal'nye sootnosheniia éffektivnosti intranazal'nogo i vnutribriushinnogo vvedeniia dermorfinov krysam.