Loss of matrix calcium-binding protein-containing neurons in Huntington's disease.
In post-mortem brain specimens from patients dying with a clinical diagnosis of Huntington's disease (HD) immunohistochemistry showed a substantial loss from the neostriatum of neurons containing the calcium-binding protein calbindin 28K. These calbindin neurons, and the straital compartment in which they are sited, are particularly damaged in HD, suggesting that a failure of calcium buffering or homeostasis may contribute to cell death in HD.
D000328:Adult; D000368:Aged; D001923:Brain Chemistry; D002135:Calcium-Binding Proteins / Q000032:analysis*; D003342:Corpus Striatum / Q000032:analysis* / Q000473:pathology; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000473:pathology*; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000032:analysis* / Q000473:pathology; D013378:Substantia Nigra / Q000032:analysis / Q000473:pathology
D002135:Calcium-Binding Proteins; C043697:calcium-binding protein (brain)