Effects of HOE 760 (histamine H2-receptor antagonist) on diazepam pharmacokinetics.
A double-blind cross-over study of the effects of HOE 760 (histamine H2-receptor blocker) on diazepam pharmacokinetics was conducted in 12 healthy men. HOE 760 or placebo was given daily for 12 days and, after a wash-out period of 9 days, the alternate medication was given for 12 days. Diazepam 10 mg was given intravenously on day 6 of each of the 12-day periods. Blood was taken up to 1 week after the diazepam injections for assay of diazepam and desmethyldiazepam. The co-administration of HOE 760 did not affect the pharmacokinetics of diazepam and desmethyldiazepam.
D000328:Adult; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000097:blood / Q000493:pharmacokinetics*; D004311:Double-Blind Method; D006207:Half-Life; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D003708:Nordazepam / Q000097:blood; D010880:Piperidines / Q000494:pharmacology*; D013997:Time Factors
D006635:Histamine H2 Antagonists; D010880:Piperidines; D003708:Nordazepam; C045914:TZU 0460; D003975:Diazepam