The pseudopterosins: anti-inflammatory and analgesic natural products from the sea whip Pseudopterogorgia elisabethae.
The Caribbean sea whip Pseudopterogorgia elisabethae (Octocorallia, Cnidaria) has been found to contain the pseudopterosins, a newly described class of natural products, which have been characterized as diterpene-pentoseglycosides. The pseudopterosins possess anti-inflammatory and analgesic properties that exceed, in our assays, the potencies of existing drugs such as indomethacin. As anti-inflammatory agents, the pseudopterosins appear to modify the arachidonic acid cascade by an as yet undefined mechanism of pharmacological action.
D000818:Animals; D000893:Anti-Inflammatory Agents; D055598:Chemical Phenomena; D002621:Chemistry; D003063:Cnidaria / Q000032:analysis*; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors
D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D006027:Glycosides; C049922:pseudopterosins; D010741:Phospholipases A; D013755:Tetradecanoylphorbol Acetate