Variation of urinary enzymes N-acetyl-beta-glucosaminidase, alanine-aminopeptidase, and lysozyme in patients receiving radio-contrast agents.
A urinary enzyme pattern consisting of two lysosomal enzymes, N-acetyl-beta-glucosaminidase and lysozyme, and one enzyme originating from kidney tubular brush border membrane, alanine-aminopeptidase, were studied in 30 patients undergoing intravenous urography and arteriography. N-acetyl-beta-glucosaminidase and lysozyme showed the greatest diagnostic sensitivity and were still abnormal on the fifth day after the administration of radio contrast agent. The results, which are statistically significant (Student's t test), suggest that radio-contrast agents are potentially nephotoxic.
D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D000626:Aminopeptidases / Q000652:urine*; D000792:Angiography; D018826:CD13 Antigens; D003287:Contrast Media / Q000009:adverse effects*; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D007687:Kidney Tubules, Proximal; D008875:Middle Aged; D009113:Muramidase / Q000652:urine*; D011507:Proteinuria / Q000652:urine; D014567:Urography
D003287:Contrast Media; D006596:Hexosaminidases; D009113:Muramidase; D000118:Acetylglucosaminidase; D000626:Aminopeptidases; D018826:CD13 Antigens