[Pathogenic properties of freshly isolated strains of the pertussis microbe].
The serovar composition, toxicity, virulence and lymphocytosis stimulating activity (LSA) of B. pertussis strains circulating in the 1980-ies were studied in comparison with the strains circulating in previous years. The study revealed changes in the toxic properties of B. pertussis: their decrease in the years of the intensive immunization of children against whooping cough and rise at the period when the number of immunized children was reduced. The toxic properties and LSA in most B. pertussis strains were less pronounced in the 1980-ies than in the 1960-ies. The serovar composition of the circulating strains remained stable for 15 years with the prevalence of serovar 1.0.3.
D000818:Animals; D001886:Bordetella pertussis / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D007928:Lethal Dose 50; D007958:Leukocyte Count; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012703:Serotyping; D014774:Virulence; D014917:Whooping Cough / Q000382:microbiology
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