Enzymes of catecholamine metabolism in the brains of rat strains differing in their preference for or tolerance of ethanol.
The activities of the catecholamine-synthesizing and inactivating enzymes were determined in whole brains of two pairs of rat strains differing in their genetically-determined behavioural responses to ethanol. The alcohol-tolerant (AT) rats did not show any significant differences in enzyme activities when compared with the non-tolerant (ANT) strain. The activity of tyrosine hydroxylase was found to be significantly higher in brains of the alcohol-preferring (AA) rats, than in those of the alcohol-non-preferring (ANA) strain.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002395:Catecholamines / Q000378:metabolism*; D004296:Dopa Decarboxylase / Q000378:metabolism; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D004361:Drug Tolerance; D005518:Food Preferences; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D002395:Catecholamines; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D004296:Dopa Decarboxylase