The effects of somatostatin and some of its tetrapeptide fragments on ethanol-induced gastric mucosal erosion in rat.
A study was made of the cytoprotective effects of somatostatin (SRIF) and its 3-6, 5-8, 7-10, 9-12 and 11-14 tetrapeptide fragments on absolute ethanol-induced haemorrhagic erosions in the stomach of rat. The SRIF molecule was found to prevent the gastric erosions induced by ethanol. The 7-10 and 11-14 fragments exhibited similar properties. There are two peaks in the cytoprotective dose-response curves. It is concluded that various fragments of SRIF can also exert cytoprotective effects.
D000818:Animals; D000431:Ethanol; D005260:Female; D009842:Oligopeptides / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D013329:Structure-Activity Relationship
D009842:Oligopeptides; D010446:Peptide Fragments; D000431:Ethanol; D013004:Somatostatin