Antagonistic effect of somatostatin on corticotropin-releasing factor-induced anorexia in the rat.
The effect of somatostatin on corticotropin-releasing factor (CRF)-induced anorexia was examined in rats. Intracerebroventricular (icv) administration of 0.11 nmol and 0.21 nmol ovine CRF significantly suppressed food intake of 24 h-starved rats. Icv administration of 0.31 nmol somatostatin 14 and somatostatin 28 partially reversed suppression of food intake induced by icv injection of 0.21 nmol CRF in 24 h-starved rats. These results suggest that somatostatin may counteract the suppressive effect of CRF on food intake within the central nervous system.
D000818:Animals; D000855:Anorexia / Q000139:chemically induced* / Q000503:physiopathology; D003346:Corticotropin-Releasing Hormone; D004435:Eating / Q000187:drug effects*; D001068:Feeding and Eating Disorders / Q000139:chemically induced*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*
D013004:Somatostatin; D003346:Corticotropin-Releasing Hormone