title: Immunomodulatory action of somatostatin.
abstract: The influence of somatostatin (SST) on spontaneous proliferation and cyclic AMP level in mouse spleen lymphocytes and on inhibition of human leukocyte migration was studied. The rate of [3H]thymidine incorporation was used as an index of proliferation. It was found that lower concentrations of SST/10(-9) and 10(-8)M, inhibited the splenocyte proliferation. In contrast, a higher SST concentration, 10(-7)M, exerted a stimulatory effect. SST in concentrations from 10(-9) to 10(-6)M did not influence cyclic AMP levels in mouse splenocytes; a significant decrease of cyclic AMP was found after the exposure to superactive SST analog RC-102-2H in concentrations 10(-8) and 10(-7)M. SST, 10(-7)M, and RC-102-2H, 10(-7)M, significantly enhanced the migration inhibition of human leukocytes induced by the exposure of leukocytes to cardiac antigen or phytohemagglutinin. The data provide evidence for an immunomodulatory action of SST.
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D013004:Somatostatin / Q000276:immunology / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology; D014020:Tissue Extracts / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D014020:Tissue Extracts; D013004:Somatostatin; D000242:Cyclic AMP