Serum antibodies to HTLV-I in human demyelinating disease.
Serum HTLV-I antibodies were measured in 17 MS patients and 2 closely matched control groups by 2 different independent assays. A highly sensitive particle agglutination test was used to detect HTLV-I core protein antigens and an immunoblot assay with E. coli-expressed P21E transmembrane protein was employed to detect antibodies to HTLV-I evelope antigens. No serologic evidence of prior HTLV-I infection in our population of multiple sclerosis (MS) or Guillain-Barré Syndrome (GBS) patients was found.
D000328:Adult; D000372:Agglutination Tests; D000914:Antibodies, Viral / Q000032:analysis*; D017977:Deltaretrovirus / Q000276:immunology*; D015480:Deltaretrovirus Antibodies; D004660:Encephalitis / Q000276:immunology; D005260:Female; D006801:Humans; D007158:Immunologic Techniques; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*; D010523:Peripheral Nervous System Diseases / Q000276:immunology; D011129:Polyradiculoneuropathy / Q000276:immunology*
D000914:Antibodies, Viral; D015480:Deltaretrovirus Antibodies