Association of Bordetella pertussis-induced hypersensitivity to serotonin with the H-2 gene complex.
Susceptibility to Bordetella pertussis-induced sensitivity to serotonin was found to be associated with the H-2 gene complex in mice. H-2 congenic and independent strains which possess the H-2b and H-2s haplotypes were susceptible to serotonin sensitization by pertussigen (P-HSF) while mice with the H-2k and H-2d haplotypes were resistant. The gene or genes which control susceptibility were found to map to the H-2SbDb end of the H-2 complex; susceptibility appears to be inherited as a co-dominant trait. These findings indicate that HLA typing may be of value in predicting or interpreting possible adverse reactions to pertussis vaccine or infection in humans.
D000818:Animals; D001886:Bordetella pertussis / Q000276:immunology*; D002874:Chromosome Mapping; D005799:Genes, Dominant; D006183:H-2 Antigens / Q000235:genetics*; D006967:Hypersensitivity / Q000235:genetics*; D007125:Immunogenetics; D051379:Mice; D008815:Mice, Inbred Strains; D037342:Pertussis Toxin; D012701:Serotonin / Q000494:pharmacology*; D010566:Virulence Factors, Bordetella / Q000276:immunology
D006183:H-2 Antigens; D010566:Virulence Factors, Bordetella; D012701:Serotonin; D037342:Pertussis Toxin