title: LY141865: a relatively selective DA2 agonist with complex ocular activity.
abstract: LY141865 (LY), an ergoline derivative, was investigated for ocular effects in rabbits and monkeys. LY lowered intraocular pressure (IOP) bilaterally in monkeys and rabbits, prevented the bilateral rise in IOP caused by oral waterloading in rabbits and slowed the rate of IOP recovery bilaterally in rabbits. The ocular hypotensive activity of LY in rabbits was inhibited by sympathectomy and pretreatment with sulpiride. Since LY has cardiovascular effects that are centrally mediated, ocular responses may also be mediated, in part, by an action in the CNS.
mesh_terms: D000818:Animals; D002428:Cebus; D015259:Dopamine Agents / Q000494:pharmacology*; D004873:Ergolines / Q000494:pharmacology*; D005123:Eye / Q000187:drug effects*; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D009184:Mydriatics / Q000494:pharmacology; D009798:Ocular Hypertension / Q000188:drug therapy; D011680:Pupil / Q000187:drug effects; D019257:Quinpirole; D011817:Rabbits; D013469:Sulpiride / Q000494:pharmacology; D013563:Sympathectomy, Chemical
chemical_list: D015259:Dopamine Agents; D004873:Ergolines; D009184:Mydriatics; D019257:Quinpirole; D013469:Sulpiride