Classification of beta-blocking agents by their inhibitory effects on phospholipase activity.
The inhibitory effects of beta-blocking agents against the action of phospholipase (PLase) were investigated. Using micelles of dimyristoyl (-)-alpha-phosphatidylcholine (DMPC) as a substrate, myristic acid (MA) released from DMPC by PLase A2 was determined by gas chromatography. Beta-Blocking agents were divided into 4 groups depending on their inhibitory effects on PLase. Their inhibitory effects on PLase could be due to their displacing ability with Ca++ on membrane phospholipids, since Ca++ is an essential factor for the activation of PLase.
D000319:Adrenergic beta-Antagonists / Q000145:classification* / Q000494:pharmacology; D004134:Dimyristoylphosphatidylcholine; D008823:Micelles; D019814:Myristic Acid; D009227:Myristic Acids / Q000032:analysis; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*
D000319:Adrenergic beta-Antagonists; D008823:Micelles; D009227:Myristic Acids; D019814:Myristic Acid; D010740:Phospholipases; D010741:Phospholipases A; D004134:Dimyristoylphosphatidylcholine