Thymus-independent antibody production to the antigen of Rickettsia prowazekii.
Antibody production has been studied in cotton B-rats and in CBA B-mice during immunization with chemical typhus vaccine (CTV) and during infection with Rickettsia prowazekii. Studies of the immune response to rickettsial antigen in T-deficient animals have shown a high immunogenicity of CTV and independence of antibody production on T-lymphocytes. Active antibody synthesis was also observed in B-rats and B-mice during Rickettsia prowazekii infection. The absence of T-lymphocyte dependence in experimental animals was tested by administration of sheep red blood cells (SRBC).
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000942:Antigens, Bacterial / Q000276:immunology*; D000955:Antigens, T-Independent / Q000276:immunology*; D003411:Arvicolinae; D001428:Bacterial Vaccines / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D012283:Rickettsia prowazekii / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014438:Typhus, Epidemic Louse-Borne / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000955:Antigens, T-Independent; D001428:Bacterial Vaccines