Coexistence of somatostatin-immunoreactivity in an adrenal pheochromocytoma and a thyroid medullary carcinoma (Sipple syndrome).
The presence of somatostatin-immunoreactivity in tumor tissue of adrenal pheochromocytoma and thyroid medullary carcinoma identified by peroxidase-antiperoxidase technique is reported in one case of Sipple syndrome. This patient was found to have a high concentration of somatostatin-immunoreactivity in the peripheral blood (40 ng/l, normal 0-20 ng/l). After removal of the tumors, the plasma somatostatin-immunoreactivity fell within normal range (12.5 ng/l). This seems to be the first report of Sipple syndrome that produces somatostatin-immunoreactivity in both: pheochromocytoma and thyroid medullary carcinoma.
D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D000328:Adult; D002277:Carcinoma / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009377:Multiple Endocrine Neoplasia / Q000175:diagnosis / Q000378:metabolism*; D010673:Pheochromocytoma / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D013004:Somatostatin / Q000097:blood / Q000276:immunology*; D013964:Thyroid Neoplasms / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*
D013004:Somatostatin