[Cytopathogenic action of intact and antibiotic-altered populations of Bordetella pertussis on a human amnion cell culture].
Cytopathogenic and adhesive action of intact B. pertussis population and population changed under the effect of antibiotics was studied comparatively. It was shown that the level and character of the changes in the cell culture of line FL human amnion depended on the antibiotic used in the experiments. Populations of B. pertussis changed under the effect of tetracycline had the highest cytopathogenic and adhesive activity, while the activity of the population changed under the effect of erythromycin was the least. The decrease in the cytopathogenic and adhesive activity of B. pertussis changed under the effect of erythromycin correlated with lowering of the toxicity and the loss of the main agglutinogenic factors of the surface of the bacteria cell wall. The increase in the toxicity of the population changed under the effect of tetracycline was accompanied by changes in the cytopathogenic and adhesive properties of the culture.
D000650:Amnion / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D001886:Bordetella pertussis / Q000187:drug effects / Q000472:pathogenicity*; D002460:Cell Line; D002478:Cells, Cultured; D006801:Humans
D000900:Anti-Bacterial Agents
Tsitopatogennoe deĭstvie intaktnykh i izmenennykh antibiotikami populiatsiĭ Bordetella pertussis na kul'turu kletok amniona cheloveka.