title: Selective alteration of mouse brain neurotransmitter release with age.
abstract: The release of acetylcholine (ACh), glutamate (GLU) and dopamine (DA) from various brain regions was investigated in young (3 month) and old (30 month) Balb/c mice. Aging increased the basal release of GLU (77%) and DA (29%) in striatum and GLU in hippocampus (94%); the concentrations of these neurotransmitters in the media after K+ stimulation were unaltered by aging. Although the basal release of ACh was not altered by age, K+-stimulated ACh release was reduced in striatum. The age-related increases in basal GLU and DA release may be important in the pathophysiology of cell death during aging.
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000375:Aging; D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D002540:Cerebral Cortex / Q000254:growth & development; D003342:Corpus Striatum / Q000254:growth & development; D004298:Dopamine / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D006624:Hippocampus / Q000254:growth & development; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009419:Nerve Tissue Proteins / Q000032:analysis; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009928:Organ Specificity
chemical_list: D005971:Glutamates; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D000109:Acetylcholine; D004298:Dopamine