Induction of double-strand breaks following neutron capture by DNA-bound 157Gd.
Irradiation of plasmid DNA/Gd3+ mixtures with thermal neutrons induces DNA double-strand breaks (dsb). However, the extent of breakage is markedly reduced by sequestering the Gd3+ from DNA by addition of EDTA. Since the 157Gd neutron capture event involves some internal conversion, we suggest that the DNA dsb induction results from Auger electron emission.
D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage; D004583:Electrons; D005682:Gadolinium / Q000528:radiation effects*; D007554:Isotopes; D009502:Neutrons; D010957:Plasmids
D007554:Isotopes; D004247:DNA; D005682:Gadolinium