Changes of cerebral gamma glutamyltransferase activities after treatment with exogenous inducers.
The activity of gamma-glutamyltransferase localized in isolated brain synaptic membranes- and microvessels-enriched fractions was assayed after treatment of rats with either phenobarbital or ethanol. Phenobarbital increased the activity of gamma-glutamyltransferase in microvessels, without alteration of synaptic membranes activity. An increase of enzyme activity was also obtained after a chronic intoxication with ethanol. These results suggest that the isoform of gamma-glutamyltransferase localized in brain microvessels may respond to exogenous inducers.
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000201:enzymology*; D002196:Capillaries / Q000201:enzymology; D004790:Enzyme Induction; D000431:Ethanol / Q000494:pharmacology; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013570:Synaptic Membranes / Q000201:enzymology; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D007527:Isoenzymes; D000431:Ethanol; D005723:gamma-Glutamyltransferase; D010634:Phenobarbital