Neuronal/lymphoid membrane glycoprotein MRC OX-2 is a member of the immunoglobulin superfamily with a light-chain-like structure.
The MRC OX-2 antigen is a membrane glycoprotein of about 45,000 Mr present on rat neurons, thymocytes, B cells, follicular dendritic cells, endothelium and smooth muscle. Sequence of cDNA clones indicates it is a member of the Ig superfamily containing 248 amino acids organized like an Ig light chain with a V-like domain and a C-like domain followed by a transmembrane and cytoplasmic sections. There is a sequence with homologies with J-regions but analysis of the gene for human OX-2 shows that this is part of the V-domain exon and there is not a separate J-region exon as in the T cell receptor or Ig chains. The relationship of OX-2 to the other Ig-related neuronal/thymocyte antigen Thy-1 and the evolution of the Ig superfamily are discussed.
D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD; D000954:Antigens, Surface / Q000032:analysis / Q000235:genetics; D005075:Biological Evolution; D055598:Chemical Phenomena; D002621:Chemistry; D005802:Genes, MHC Class II; D007127:Immunoglobulin Constant Regions; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region; D051381:Rats; D018800:Thy-1 Antigens
D015703:Antigens, CD; D000954:Antigens, Surface; D007127:Immunoglobulin Constant Regions; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region; D018800:Thy-1 Antigens; C042739:antigens, CD200