Effects of H-2 antagonists on the elimination of bupivacaine.
The effects of two histamine H-2 antagonists, cimetidine and ranitidine, on the elimination of bupivacaine were studied in four male volunteers. The cimetidine-treated group demonstrated a statistically significant decrease in clearance of bupivacaine. These results indicate that concomitant administration of cimetidine and bupivacaine may increase the likelihood of toxicity of the latter agent.
D002045:Bupivacaine / Q000378:metabolism*; D002927:Cimetidine / Q000494:pharmacology; D004347:Drug Interactions; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D011899:Ranitidine / Q000494:pharmacology
D006635:Histamine H2 Antagonists; D002927:Cimetidine; D011899:Ranitidine; D002045:Bupivacaine