[Changes in the system of cyclic nucleotides in irradiated body tissues].
It has been shown that the content of cAMP in the rat thymus, spleen, and liver 1 and 3 days after gamma-radiation with 7.5 Gy decreases, and that of cGMP increases. Analogous dynamics has been revealed when studying adenylate cyclase and guanylate cyclase activities. The activity of cAMP and cGMP phosphodiesterases increased during the first period of study but subsequently it showed no distinction from the initial data level. The revealed postradiation changes in the content of cyclic nucleotides seem to be basically caused by the cyclases activity alterations.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002588:Cesium Radioisotopes; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D005720:Gamma Rays; D006162:Guanylate Cyclase / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000378:metabolism / Q000528:radiation effects*; D013950:Thymus Gland / Q000378:metabolism / Q000528:radiation effects*
D002588:Cesium Radioisotopes; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase; D006152:Cyclic GMP
Izmeneniia v sisteme tsiklicheskikh nukleotidov v tkaniakh obluchennogo organizma]