title: The effect of pancreatectomy and gastroenterectomy on the release of somatostatin and vasoactive intestinal polypeptide in experimental fecal peritonitis.
abstract: Rats were subjected to laparotomy, to pancreatectomy, to gastroenterectomy (control groups), or to these procedures plus a septic challenge by instillation of 0.1 ml feces intraperitoneally (experimental groups). In the laparotomized controls plasma somatostatin values were significantly higher in samples from the portal vein than from the upper inferior caval vein. After both pancreatectomy and gastroenterectomy a significant fall in plasma somatostatin values was observed, and there was no significant difference between samples taken from the portal vein and the systemic circulation. An intraperitoneal septic challenge elicited a significant rise in portal plasma somatostatin in laparotomized rats, whereas this increase did not occur in pancreatectomized and gastroenterectomized animals, supporting the notion that plasma somatostatin originates from the pancreas and/or the gastrointestinal tract during septic peritonitis. No differences were detected in plasma vasoactive intestinal polypeptide (VIP) values in animals from the three control groups. However, both in laparotomized and in pancreatectomized septic animals a significant rise in plasma VIP was demonstrated in samples from the portal vein. By contrast, no such increase was observed in gastroenterectomized septic rats. Thus, the gastrointestinal tract seems to be the major source of circulating VIP during fecal peritonitis in the rat.
mesh_terms: D000818:Animals; D005243:Feces; D005743:Gastrectomy; D007422:Intestines / Q000601:surgery*; D008297:Male; D010180:Pancreatectomy; D010538:Peritonitis / Q000097:blood / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000097:blood*; D014660:Vasoactive Intestinal Peptide / Q000097:blood*
chemical_list: D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin