[Prediction of the parameters of the accumulation of 1,4-benzodiazepine derivatives in the body of mice based on their excretory kinetics].
Kinetics of 14C-7-bromo-5-phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-one (I) excretion from the mouse body following a single and long-term administration of the compound was studied. It was shown that kinetics of excretion of total radioactive material in the urine and feces is a sum of monoexponential processes. Prediction of the compound accumulation in the mouse body during its long-term administration was performed. Parameters of accumulation of the compound, diazepam, chlordiazepoxide and phenazepam were compared. Significant, reciprocally compensated changes in relative efficacy and the rate of excretion of total radioactivity in the urine and feces during a long-term administration were noted. It is recommended to take into consideration the events studied at a chronic administration of derivatives of 1,4-benzodiazepine.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000032:analysis / Q000378:metabolism*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000032:analysis / Q000378:metabolism*; D002250:Carbon Radioisotopes; D005243:Feces / Q000032:analysis; D007700:Kinetics; D008297:Male; D008433:Mathematics; D051379:Mice; D008808:Mice, Inbred CBA; D011379:Prognosis; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D002250:Carbon Radioisotopes; D001569:Benzodiazepines; C051604:7-bromo-5-phenyl-1,2-dihydro-2H-1,4-benzodiazepin-2-one
Prognozirovanie parametrov nakopleniia v organizme mysheĭ proizvodnykh 1,4-benzdiazepina na osnove ikh kinetiki vyvedeniia.