title: Alpha-interferon therapy for essential thrombocythaemia.
abstract: 18 patients with symptomatic essential thrombocythaemia were treated with recombinant alpha interferon (2a or 2b). Subcutaneous dosage regimens, which were well-tolerated, selectively lowered the platelet count and relieved symptoms in all patients, whether previously treated or untreated. Recombinant alpha-interferon may offer a non-leukaemogenic alternative therapy for these patients.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D013920:Thrombocythemia, Essential / Q000097:blood / Q000628:therapy*
chemical_list: D006454:Hemoglobins; D007370:Interferon Type I