title: Comparative studies on growth of foot-and-mouth disease virus types 0 and Asia 1 in BHK-21 Razi cells.
abstract: Growth pattern of foot-and-mouth disease virus types 0 and Asia 1 in BHK-21 Razi cells was compared; while type 0 virus grew in high titre, Asia 1 virus was produced in low titre. Inhibition of host protein synthesis in type 0 virus-infected cells was more pronounced than in Asia 1 virus-infected cells. Foot-and-mouth disease virus type 0 infected cells showed higher lactic dehydrogenase activity when compared to Asia 1 virus. A significant decrease in virus yield was observed when Actinomycin D had been added at 50 micrograms/ml to infected cells.
mesh_terms: D000818:Animals; D005537:Aphthovirus / Q000187:drug effects / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D002460:Cell Line; D006224:Cricetinae; D003609:Dactinomycin / Q000494:pharmacology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D014176:Protein Biosynthesis; D012367:RNA, Viral / Q000096:biosynthesis / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
chemical_list: D012367:RNA, Viral; D003609:Dactinomycin; D007770:L-Lactate Dehydrogenase