The effect of artificially induced hyperglycemia on the radiation response of the Lewis lung and EMT6 tumor models.
The effect of hyperglycemia, induced by administration of glucose, on the radiation response of the Lewis lung and EMT6 tumor models has been evaluated. Neither acute (single i.p. injection of 8 mg/glucose) nor chronic (multiple i.p. injections of 6 mg/g glucose plus glucose in the water bottles) administrations of glucose increased the radiation response of either tumor. A combination of a single i.p. injection of glucose and a reduction of the O2 content of the inspired gas to 10 per cent did by itself reduce cell survival by 55-75 per cent in the EMT6 and 80-90 per cent in the Lewis lung carcinoma. However, this treatment had little effect on the shape of the radiation dose-response curve, and simply gave rise to a parallel shift of the survival curve, indicating that this treatment had little or no specificity for hypoxic cells.
D000818:Animals; D001786:Blood Glucose / Q000502:physiology*; D002470:Cell Survival / Q000528:radiation effects; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000532:radiotherapy*
D001786:Blood Glucose