Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome.
The murine locus corresponding to the human Duchenne/Becker muscular dystrophy (DMD) gene has been regionally mapped on the mouse X chromosome by hybridizing DNA from interspecies mouse crosses with a cDNA clone for the mouse Dmd gene. The results demonstrate that the relative organization of genes on the murine and human X chromosomes is more divergent than has previously been postulated. Furthermore, the mouse Dmd gene maps to a similar region of the X chromosome as does the mouse muscular dystrophy mutation mdx, providing further evidence that the mdx mutant may be a murine equivalent of human DMD. However, Southern analysis of portions of the mouse Dmd gene has not yet revealed any differences between mdx and wild-type mice.
D000818:Animals; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D004195:Disease Models, Animal; D008040:Genetic Linkage; D006801:Humans; D051379:Mice; D009137:Muscular Dystrophy, Animal / Q000235:genetics*; D009154:Mutation; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length; D013045:Species Specificity; D014960:X Chromosome
D004247:DNA