Tardive dyskinesia and steady-state serum levels of thiothixene.
The purpose of this investigation was to determine the relationship between serum levels of the neuroleptic agent thiothixene and tardive dyskinesia in schizophrenics of a wide age range. Forty-one male schizophrenic subjects, 21 with tardive dyskinesia and 20 without, were given a fixed dosage of thiothixene hydrochloride (10 mg orally four times daily) after a drug-free period of one week. Higher steady-state serum levels of thiothixene (obtained after five days of a fixed-dosage schedule) were associated with greater degrees of tardive dyskinesia. This relationship was independent of the relationship between tardive dyskinesia and age.
D000328:Adult; D000367:Age Factors; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000097:blood; D004409:Dyskinesia, Drug-Induced / Q000097:blood / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012306:Risk; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D013888:Thiothixene / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use
D014150:Antipsychotic Agents; D013888:Thiothixene