Lymphocyte beta-adrenergic receptor binding in panic disorder.
Lymphocyte beta adrenergic receptor binding using [125I]CNP was determined in patients with panic disorder (N = 4) or agoraphobia with panic attacks (N = 17) and age- and sex-matched healthy subjects (N = 22). The patients showed a significantly lower number of beta-adrenergic receptor binding sites and a significantly higher affinity of binding than healthy subjects. A past or present history of major depression in the patients did not alter these findings. These results are consistent with a growing body of knowledge implicating noradrenergic dysfunction in the pathophysiology of panic anxiety.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000379:Agoraphobia / Q000378:metabolism*; D003866:Depressive Disorder / Q000378:metabolism; D005239:Fear / Q000502:physiology*; D005260:Female; D006160:Guanosine Triphosphate / Q000502:physiology; D006801:Humans; D007457:Iodine Radioisotopes; D020120:Iodocyanopindolol; D007700:Kinetics; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000502:physiology*; D010698:Phobic Disorders / Q000378:metabolism*; D010869:Pindolol / Q000031:analogs & derivatives; D011569:Psychiatric Status Rating Scales; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D007457:Iodine Radioisotopes; D011943:Receptors, Adrenergic, beta; D020120:Iodocyanopindolol; D006160:Guanosine Triphosphate; D010869:Pindolol