[Regulation by catecholamines and cAMP of enzymes of thiol and disulfide metabolism].
In vivo exo- and endogenous catecholamines have no influence on the activities of thioredoxin reductase, glutathione reductase, thiol transferase and nonselenium-dependent glutathione peroxidase. At the same time catecholamines activate via beta-adrenoceptors glutathione S-transferase and selenium-dependent glutathione peroxidase from many tissues and inhibit gamma-glutamyl transferase from kidney. In vitro cAMP has identical effects on the activities of the above enzymes. The possible significance of regulation of glutathione metabolism enzymes is discussed.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D002395:Catecholamines / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology*; D004220:Disulfides / Q000378:metabolism*; D004789:Enzyme Activation; D005260:Female; D005979:Glutathione Peroxidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors / Q000378:metabolism; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000201:enzymology / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D013880:Thioredoxin-Disulfide Reductase / Q000037:antagonists & inhibitors / Q000378:metabolism; D014018:Tissue Distribution; D005723:gamma-Glutamyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism
D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D002395:Catecholamines; D004220:Disulfides; D013438:Sulfhydryl Compounds; D000242:Cyclic AMP; D005979:Glutathione Peroxidase; D013880:Thioredoxin-Disulfide Reductase; D005723:gamma-Glutamyltransferase; D005982:Glutathione Transferase
Issledovanie reguliatsii katekholaminami i cAMP fermentov obmena tiolov i disul'fidov.