[Effect of sub-bacteriostatic doses of aztreonam on the adhesion of Pseudomonas aeruginosa].
The effect of sub-inhibitory concentrations of Aztreonam towards the adhesiveness of an uropathogenic strain of P. aeruginosa was tested. The filamentous forms, morphologically altered by the action of the antibiotic, were not capable of adhering to human uroepithelial cells. This phenomenon was due to an alteration of bacterial structures responsible for the adhesion and was not related to a steric hindrance caused by the antibiotic on either the bacterial structures or the cell receptors.
D001398:Aztreonam / Q000008:administration & dosage / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D010861:Fimbriae, Bacterial / Q000187:drug effects; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000502:physiology*
D001398:Aztreonam
Effetto di dosi sub-batteriostatiche di aztreonam sull'adesivita' di Pseudomonas aeruginosa.