title: Nosocomial Legionnaires' disease: a global perspective.
abstract: Nosocomial Legionnaires' disease is a worldwide problem. The lack of prospective surveys using sensitive diagnostic means, such as culture, has resulted in ignorance about the exact magnitude of the problem except at a handful of individual hospitals. Contaminated hospital hot water systems, cooling towers, and non-sterile tap water used for respiratory therapy may all cause disease. Culture diagnosis is the preferred method of case ascertainment, and provides bacterial isolates which can be used to implicate specific environmental sites using molecular epidemiologic techniques. Environmental culture surveys, done in the absence of known disease, are probably not indicated, but there remains concern that wards housing very high risk patients should be legionella-free. Use of monoclonal antibody typing of environmental isolates of L. pneumophila serogroup 1 may be useful in this regard, as it can possibly detect strains most likely to cause disease. Control of nosocomial disease requires centralized management and consultation by expert engineers, epidemiologists, and microbiologists.
mesh_terms: D001431:Bacteriological Techniques; D003428:Cross Infection / Q000453:epidemiology*; D004196:Disease Outbreaks / Q000453:epidemiology; D004783:Environmental Microbiology; D004812:Epidemiologic Methods; D006801:Humans; D007875:Legionella / Q000302:isolation & purification; D007877:Legionnaires' Disease / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission; D014871:Water Microbiology; D014881:Water Supply / Q000032:analysis