Oesophageal varices associated with busulphan-thioguanine combination therapy for chronic myeloid leukaemia.
5 patients receiving continuous busulphan and 6-thioguanine for chronic myeloid leukaemia (CML) were found to have oesophageal varices associated with abnormal liver function tests. 3 of these cases presented with gastrointestinal haemorrhage and 1 patient died. The 2 other cases had varices discovered at endoscopy. Nodular regenerative hyperplasia (NRH) of the liver was identified as the cause of portal hypertension in the 4 patients on whom liver biopsies were done. The administration of busulphan and thioguanine in combination is likely to be associated with the development of NRH, with portal hypertension and oesophageal varices occurring in a substantial proportion of cases.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002066:Busulfan / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D004932:Esophageal and Gastric Varices / Q000139:chemically induced*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006801:Humans; D006965:Hyperplasia; D007951:Leukemia, Myeloid / Q000188:drug therapy*; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013866:Thioguanine / Q000008:administration & dosage* / Q000009:adverse effects
D013866:Thioguanine; D002066:Busulfan