Pharmacological effects of various venoms on cutaneous capillary leakage.
Studies to counteract the cutaneous vasopermeability actions of a wasp (Vespa orientalis), an anemone (Bolocera tuediae) and three jellyfish (Chironex fleckeri, Chrysaora quinquecirrha and Physalia physalis) venoms were conducted by using various pharmacological antagonists. Piripost (a leukotriene inhibitor) reduced vasopermeability if administered 5 min prior to challenge with the jellyfish venoms. Methysergide counteracted the vasopermeability of three of four coelenterate venoms, whereas indomethacin was effective against capillary leakage induced by Chironex venom. These studies indicate that anti-dermonecrotic therapy against various venoms will have to be species-specific.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001514:Bee Venoms / Q000037:antagonists & inhibitors*; D002199:Capillary Permeability / Q000187:drug effects*; D003064:Cnidarian Venoms / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004205:Cromolyn Sodium / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology / Q000031:analogs & derivatives; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D051381:Rats; D013189:SRS-A / Q000037:antagonists & inhibitors; D037401:Scyphozoa; D012615:Sea Anemones; D012867:Skin / Q000098:blood supply; D014862:Wasp Venoms / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D001514:Bee Venoms; D003064:Cnidarian Venoms; D013189:SRS-A; D014862:Wasp Venoms; D011464:Epoprostenol; D004205:Cromolyn Sodium; C035296:piriprost; D008784:Methysergide