A surface test for virucidal activity of disinfectants: preliminary study with herpes virus.
A test was developed to assess the surface activity of disinfectants against dried viral preparations. In this preliminary study a variety of disinfectants was tested against herpes virus. The results showed that 2% alkaline glutaraldehyde and 70% ethanol or isopropanol were effective in 1 min. Hypochlorite solutions (2500 ppm av. Cl2) were effective in 5 min, but povidone-iodine (10%) was slower in action and a clear soluble phenol showed uncertain activity at 5 and 10 min. High concentrations of alcohols (above 95%), two quaternary ammonium compounds and 0.5% aqueous chlorhexidine showed little activity in 10 min.
D000438:Alcohols / Q000494:pharmacology; D000818:Animals; D001548:Benzalkonium Compounds / Q000494:pharmacology; D002460:Cell Line; D002710:Chlorhexidine / Q000494:pharmacology; D004202:Disinfectants / Q000494:pharmacology*; D004492:Edetic Acid / Q000494:pharmacology; D005976:Glutaral / Q000494:pharmacology; D006997:Hypochlorous Acid / Q000494:pharmacology; D010636:Phenols / Q000494:pharmacology; D011206:Povidone-Iodine / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects*
D000438:Alcohols; D001548:Benzalkonium Compounds; D004202:Disinfectants; D010636:Phenols; D000644:Quaternary Ammonium Compounds; D006997:Hypochlorous Acid; D011206:Povidone-Iodine; D004492:Edetic Acid; D002710:Chlorhexidine; D005976:Glutaral