Evidence that the cultured multipolar neurons of the lower brainstem of SHR and WKY rats differ significantly in the mode of responses to catecholamines.
By using cultures of 6 types of dissociated neurons from the lower brainstem of spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats, we analyzed differences in the mode of response of the cultured neurons to 9 kinds of peptides and 7 kinds of neurotransmitters, and obtained evidence that there is a significant difference in the mode of response of multipolar neurons to catecholamines; dominantly facilitation in SHR, but dominantly inhibition in WKY rats.
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001933:Brain Stem / Q000187:drug effects / Q000502:physiology*; D002395:Catecholamines / Q000494:pharmacology*; D002478:Cells, Cultured; D005071:Evoked Potentials / Q000187:drug effects; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D009433:Neural Inhibition / Q000187:drug effects; D009474:Neurons / Q000145:classification / Q000187:drug effects / Q000502:physiology; D009479:Neuropeptides / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*; D011921:Rats, Inbred WKY / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D002395:Catecholamines; D005971:Glutamates; D009479:Neuropeptides; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine