title: Protein polymorphisms detected by two-dimensional electrophoresis: an analysis of overall informativeness of a panel of linkage markers.
abstract: Forty-two independent polymorphic loci are detectable by two-dimensional electrophoresis (2DE) of four peripherally accessible human tissues. Fifteen have been chromosomally mapped and, taken together, these constitute a useful panel of markers for genetic linkage studies in humans. An analysis of the overall informativeness for linkage of this panel of markers is presented, taking into account the effect of varying the number of families or matings studies. Use of 2DE polymorphic markers for linkage of genetically determined behaviour traits in humans and mice is reviewed.
mesh_terms: D001798:Blood Proteins / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D010641:Phenotype; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D001798:Blood Proteins; D005819:Genetic Markers