title: DNA polymorphism and the study of disease associations.
abstract: Recombinant DNA approaches to disease analysis may be as applicable to studies of disease association as they are to the analysis and diagnosis of single-gene defects. Population and/or family association analyses, using restriction fragment length polymorphisms around candidate genes as markers, have been employed to study conditions such as atherosclerosis and disease with an HLA-association. Progress made to date in disease-association studies using recombinant DNA methodology is reviewed, the rationale behind such studies is examined and associated problems and pitfalls discussed.
mesh_terms: D000483:Alleles; D001161:Arteriosclerosis / Q000235:genetics; D004247:DNA / Q000032:analysis*; D004274:DNA, Recombinant; D004198:Disease Susceptibility / Q000175:diagnosis; D004992:Ethics, Medical; D005787:Gene Frequency; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D004274:DNA, Recombinant; D005819:Genetic Markers; D006680:HLA Antigens; D004247:DNA