Effect of human menopausal gonadotrophin on the non-pregnant uterine response to intrauterine administration of prostaglandin E2.
The effect of intrauterine instillation of 50 micrograms of prostaglandin E2 (PGE2) on the non-pregnant human uterus was evaluated in 10 volunteers, before and after systemic administration of human menopausal gonadotrophin (HMG). The cases were either in the early proliferative (n = 5) or late secretory (n = 5) phases of the cycle. Before HMG administration, the uterus responded to local PGE2 by stimulation in all the cases. After HMG treatment, no response to PGE2 was detected in eight cases and a decrease in uterine tonus was observed in two cases. The implications of these findings in certain physiological and pathological conditions relating to reproduction are discussed.
D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D015232:Dinoprostone; D005260:Female; D006801:Humans; D008596:Menotropins / Q000494:pharmacology*; D008597:Menstrual Cycle; D011458:Prostaglandins E / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects*
D011458:Prostaglandins E; D008596:Menotropins; D015232:Dinoprostone