Risk of hypoglycaemia with alternate-day growth hormone injections.
Fasting hypoglycaemia developed in three growth hormone deficient children after the start of treatment with synthetic growth hormone. The effects, which occurred 36-60 h after each injection, may have been due to insulin-like effects of endogenous somatomedins after waning of insulin antagonism induced by growth hormone. Daily growth hormone injections may be necessary to maintain normal plasma glucose levels in young children.
D001786:Blood Glucose / Q000378:metabolism; D002675:Child, Preschool; D013006:Growth Hormone / Q000008:administration & dosage*; D006728:Hormones / Q000008:administration & dosage*; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007018:Hypopituitarism / Q000097:blood; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D008297:Male; D012306:Risk; D013002:Somatomedins / Q000502:physiology; D013997:Time Factors
D001786:Blood Glucose; D006728:Hormones; D013002:Somatomedins; D013006:Growth Hormone