Bidirectional transfer between kindling induced by excitatory amino acids and electrical stimulation.
Chemical (C) kindling by means of repeated spaced injections into the amygdala (AM) of a subconvulsive dose of L-glutamate and L-aspartate combined in a molar ratio of 1:3. (Glu/Asp) produced progressive seizure development culminating in generalized convulsion strikingly similar to electrically kindled Stage 5 seizure in rats. These C-kindled AM sites responded readily to electrical stimulation with very rapid development of kindled seizure. When a separate group of rats electrically kindled at the AM were subjected to identical C-kindling at the kindled AM site, a similar positive transfer effect was observed. In addition, 30 days following the last injection, kindled Stage 5 seizure was triggered with a single injection of Glu/Asp, one-half of the dose used for C-kindling. These results suggest that the glutamate and/or aspartate systems participate in the development and persistence of increased seizure susceptibility induced by AM kindling.
D000679:Amygdala / Q000502:physiology; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D004558:Electric Stimulation; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D007267:Injections; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid