Measurement ex-vivo of the inhibition of fatty acid biosynthesis by bezafibrate administration in different rat tissues.
The action of bezafibrate on fatty acid biosynthesis pathways has been examined in rat tissues. The drug abolished the induction of fatty acid synthesis that occurs on refeeding the animals with a high carbohydrate diet and by insulin administration in liver and adipose tissue. The rates of fatty acid biosynthesis in these tissues were estimated from the incorporation of 3H into lipids from 3H2O.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001629:Bezafibrate / Q000494:pharmacology*; D005227:Fatty Acids / Q000096:biosynthesis*; D005260:Female; D007328:Insulin / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D005227:Fatty Acids; D007328:Insulin; D001629:Bezafibrate