title: Topoisomerases in human disease.
abstract: Topoisomerases are DNA-modifying enzymes that are becoming increasingly important in clinical practice. These enzymes form a target for antibiotics, autoantibodies, and antitumour drugs, and may also be involved in the pathogenesis of certain genetic disorders. Strategies for clinical manipulation of these nuclear enzyme targets are discussed.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D001323:Autoantibodies / Q000276:immunology; D004264:DNA Topoisomerases, Type I / Q000276:immunology / Q000378:metabolism*; D004250:DNA Topoisomerases, Type II / Q000235:genetics / Q000378:metabolism*; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D001323:Autoantibodies; D004264:DNA Topoisomerases, Type I; D004250:DNA Topoisomerases, Type II