[Pathogenesis of cerebral disorders in hepatocerebral dystrophy].
On the basis of data obtained in the course of long-term observation of more than 60 patients with hepatocerebral dystrophy and analysis of the literature the authors consider the problems related to the pathogenesis of cerebral disorders in this disease. It has been found that the underlying mechanisms of the disorder is chronic intoxication of the central nervous system which is induced by the glut of "non-ceruloplasmin" copper and brings about a cascade of secondary metabolic disturbances, including defect of the amino acid pool in the blood plasma, zinc deficit, and disorders of redox processes. The possible role of each of these disorders has been considered in the pathogenesis of cerebral disturbances associated with hepatocerebral dystrophy.
D000596:Amino Acids / Q000097:blood; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D055598:Chemical Phenomena; D002621:Chemistry; D003300:Copper / Q000032:analysis / Q000097:blood; D006527:Hepatolenticular Degeneration / Q000209:etiology*; D006801:Humans; D008099:Liver / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000378:metabolism; D010084:Oxidation-Reduction; D015032:Zinc / Q000172:deficiency
D000596:Amino Acids; D018377:Neurotransmitter Agents; D003300:Copper; D015032:Zinc
O patogeneze tserebral'nykh narusheniĭ pri gepatotserebral'nom distrofii.