Nicotine cue in rats: effects of central administration of ganglion-blocking drugs.
In rats trained to discriminate nicotine from saline, a single intraventricular injection of a small dose of the quaternary ganglion-blocking drug chlorisondamine blocked the response to nicotine for four weeks. pentolinium was only weakly active and hexamethonium was inactive as a nicotine antagonist under the conditions used, even in doses that were just below those producing myoclonic jerks. Chlorisondamine had no blocking effect in rats trained to discriminate the non-nicotinic drugs midazolam or morphine from saline. Intraventricular injections of chlorisondamine have a specific and unusually persistent nicotine-blocking action, the mechanism of which requires further investigation.
D000818:Animals; D002714:Chlorisondamine / Q000494:pharmacology*; D003463:Cues; D004193:Discrimination Learning / Q000187:drug effects*; D004347:Drug Interactions; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D008874:Midazolam / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D009538:Nicotine / Q000037:antagonists & inhibitors*; D010425:Pentolinium Tartrate / Q000494:pharmacology; D051381:Rats
D006584:Hexamethonium Compounds; D018738:Hexamethonium; D009538:Nicotine; D009020:Morphine; D010425:Pentolinium Tartrate; D002714:Chlorisondamine; D008874:Midazolam