Enhancement of capsaicin-induced contraction of guinea-pig tracheal smooth muscle by vanadate.
Contractions of guinea-pig isolated tracheal smooth muscle by submaximal capsaicin (0.1 microM) were enhanced by 43% (P less than 0.01) after vanadate (10 microM for 10 min) preincubation. Contractile responses to acetylcholine (0.1-100 microM), histamine (1-100 microM) or substance P (0.01-1 microM) were, in contrast, not affected by prior vanadate exposure. It is suggested that tachykinin release from capsaicin-sensitive afferent nerve endings within the airways was enhanced by vanadate while airway smooth muscle reactivity remained unchanged.
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D014132:Trachea / Q000187:drug effects; D014638:Vanadates / Q000494:pharmacology*
D014638:Vanadates; D002211:Capsaicin