The action of hormones on the rat uterus and mammary gland gamma-glutamyltranspeptidase activity.
The gamma-glutamyltranspeptidase activity of rat uterus and mammary gland was studied in ovariectomized, hypophysectomized and ovariectomized-hypophysectomized rats under different hormonal and drug treatments. The uterine enzyme appears to be mainly dependent on a direct action of estradiol and the mammary gland enzymatic activity is dependent on prolactin. Our result, however, do not exclude a possible role of estradiol in the regulation of prolactin effects on mammary gland enzymatic activity.
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D005260:Female; D006728:Hormones / Q000494:pharmacology*; D007016:Hypophysectomy; D008321:Mammary Glands, Animal / Q000201:enzymology*; D010052:Ovariectomy; D011388:Prolactin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000187:drug effects*; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D006728:Hormones; D001971:Bromocriptine; D011388:Prolactin; D005723:gamma-Glutamyltransferase