Serotonin induced protein phosphorylation in the Aplysia eye.
Serotonin (5-HT) increases the phosphorylation of two low molecular weight phosphoproteins of 23,000 and 15,000 daltons molecular weight and decreases the phosphorylation of a 20,000 dalton phosphoprotein in the isolated Aplysia eye. The cAMP analog 8-benzylthio cAMP increases and decreases the phosphorylation of the 23,000 and 20,000 dalton 5-HT sensitive phosphoproteins, respectively. The effect of 5-HT on protein phosphorylation is not affected by the phase of the circadian rhythm of spontaneous compound action potentials generated in the eye.
D000818:Animals; D001048:Aplysia / Q000378:metabolism*; D001345:Autoradiography; D000242:Cyclic AMP / Q000031:analogs & derivatives / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D005136:Eye Proteins / Q000378:metabolism*; D066298:In Vitro Techniques; D008970:Molecular Weight; D010761:Phosphorus Radioisotopes; D010766:Phosphorylation; D012701:Serotonin / Q000494:pharmacology*
D005136:Eye Proteins; D010761:Phosphorus Radioisotopes; C024322:8-thio-benzyl cyclic AMP; D012701:Serotonin; D000242:Cyclic AMP