Defective human immunodeficiency virus (HIV) particles produced by cloned cells of HTLV-I-carrying MT-4 cells persistently infected with HIV.
Persistently HIV-infected cell lines were isolated from surviving and proliferating cells after infection of HTLV-I-carrying MT-4 cells with cell-free human immunodeficiency virus (HIV); HTLV-IIIB and LAV. The media of the cloned cell cultures did not cause HIV infection of MT-4, MOLT-4, TALL-1, or HL-60 cells. Most of the constituents of the virus in the media were env proteins and many defective doughnut-shaped particles released from the cells were identified by electron microscopy.
D002460:Cell Line; D002472:Cell Transformation, Viral; D002999:Clone Cells / Q000382:microbiology / Q000648:ultrastructure; D003673:Defective Viruses / Q000032:analysis / Q000502:physiology* / Q000648:ultrastructure; D017977:Deltaretrovirus / Q000502:physiology*; D006800:Deltaretrovirus Infections / Q000382:microbiology* / Q000473:pathology; D006678:HIV / Q000032:analysis / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D014759:Viral Envelope Proteins / Q000302:isolation & purification; D014779:Virus Replication
D014759:Viral Envelope Proteins