Linkage relationship between retinoschisis and four marker loci.
The linkage relationship between the locus for juvenile retinoschisis (RS) and four X-chromosomal marker loci DXS9 (RC8), DXS16 (XUT23), DXS41 (99-6), and DXS43 (D2) has been studied in six families showing a history of this disease. Recombination with RS was found for all marker loci except DXS9. The maximum lod score is zeta = 2.66 for RS vs. DXS9 at a recombination fraction of theta = 0.0. Multipoint linkage analysis was performed and the locus order best supported by our data is: RS - DXS9 - DXS43 - DXS16 - DXS41.
D008040:Genetic Linkage; D006801:Humans; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D012163:Retinal Detachment / Q000235:genetics*; D014960:X Chromosome