Effects of five alpha-blockers on the hypogastric nerve stimulation of the canine lower urinary tract.
Electrical stimulation of the hypogastric nerve increased both urethral and bladder pressures of anaesthetized male dogs, without affecting cardiovascular parameters. Intravenous injections of prazosin, phentolamine, thymoxamine, phenoxybenzamine and yohimbine inhibited the urethral pressure increase in a dose-dependent manner, but the increase in bladder pressure was not modified by these alpha-blockers.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D007001:Hypogastric Plexus / Q000502:physiology*; D008297:Male; D013948:Moxisylyte / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D011312:Pressure; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D014521:Urethra / Q000187:drug effects / Q000294:innervation*; D001743:Urinary Bladder / Q000294:innervation*; D014555:Urination Disorders / Q000503:physiopathology; D015016:Yohimbine / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D011942:Receptors, Adrenergic, alpha; D010643:Phenoxybenzamine; D015016:Yohimbine; D013948:Moxisylyte; D011224:Prazosin; D010646:Phentolamine