Glutamate recognition sites in human fetal brain.
We used in vitro autoradiography with [3H]glutamate to examine the distribution of glutamate recognition sites in 18 and 21 week gestation human fetal brains. We found a wide distribution of [3H]glutamate binding in both specimens, in a pattern distinct from that reported in adult brain using the same autoradiographic methods. In fetal brain, prominent [3H]glutamate binding was evident in hippocampal formation, caudate-putamen, globus pallidus, subthalamic nucleus, reticular nucleus of thalamus and substantia innominata.
D001345:Autoradiography; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D006801:Humans; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D014018:Tissue Distribution
D005971:Glutamates; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D018698:Glutamic Acid