Antihypertensive effect of beta blockade in renal transplant recipients with or without host kidneys.
Host kidneys may contribute considerably to hypertension after renal transplantation. Their role in sustaining hypertension is more prominent if glomerulonephritis (GN) than if interstitial nephritis (IN) is the original renal disease. We compared the antihypertensive effect of beta-blockade in IN (n = 10) and GN (n = 19) hypertensive renal transplant recipients with host kidneys in situ with those who had undergone bilateral nephrectomy (BN, n = 10). Pretreatment blood pressures were comparable in BN, IN, and GN patients, being 165 +/- 6/108 +/- 3, 172 +/- 5/104 +/- 3, and 161 +/- 3/104 +/- 1, mmHg, respectively. Blood pressure did not change on beta-blockade in BN patients, whereas it decreased significantly more (P less than 0.001) in GN than in IN patients, changes of mean arterial pressure being -107 +/- 1.0, -14.9 +/- 1.3, and -6.8 +/- 1.6%, respectively. This failure to respond to beta-blockade in patients without host kidneys may be related to low activity of the renin-angiotensin system or to functional denervation of the grafted kidney. Further investigations of this phenomenon may clarify the mechanism of antihypertensive action of beta-blockade as well as the nature of hypertension after renal transplantation.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000809:Angiotensins / Q000502:physiology; D001262:Atenolol / Q000627:therapeutic use; D006801:Humans; D006977:Hypertension, Renal / Q000188:drug therapy*; D007668:Kidney / Q000503:physiopathology; D016030:Kidney Transplantation; D008790:Metoprolol / Q000627:therapeutic use; D009392:Nephrectomy; D011433:Propranolol / Q000627:therapeutic use; D012083:Renin / Q000502:physiology; D012189:Retrospective Studies
D000319:Adrenergic beta-Antagonists; D000809:Angiotensins; D001262:Atenolol; D011433:Propranolol; D012083:Renin; D008790:Metoprolol