title: Patterns and timing of Doppler-detected intracavitary and aortic flow in hypertrophic cardiomyopathy.
abstract: This study describes the velocity characteristics of left ventricular and aortic outflow in 25 patients with hypertrophic "obstructive" cardiomyopathy. Systematic pulsed and continuous wave Doppler analysis combined with phonocardiography and M-mode echocardiography was used to establish the pattern and timing of outflow in the basal and provoked states. This analysis suggests that 1) the high velocity left ventricular outflow jet can be reliably discriminated from both aortic flow and the jet of mitral regurgitation using Doppler ultrasound; 2) the Doppler velocity contour responds in a characteristic fashion to provocative influences including extrasystole and Valsalva maneuver; 3) the onset of mitral regurgitation occurs well before detectable systolic anterior motion of the mitral valve; 4) left ventricular flow velocities are elevated at the onset of systolic anterior motion of the mitral valve, suggesting a significant contribution of the Venturi effect in displacing the leaflets and chordae; 5) the high velocities of the outflow jets are largely dissipated by the time flow reaches the aortic valve; and 6) late systolic flow in the ascending aorta is nonuniform, with formation of distinct eddies that may contribute to "preclosure" of the aortic valve.
mesh_terms: D000680:Amyl Nitrite; D001021:Aortic Valve / Q000503:physiopathology; D001783:Blood Flow Velocity; D002312:Cardiomyopathy, Hypertrophic / Q000503:physiopathology*; D004452:Echocardiography; D006801:Humans; D008943:Mitral Valve / Q000503:physiopathology; D008944:Mitral Valve Insufficiency / Q000503:physiopathology; D009200:Myocardial Contraction; D013318:Stroke Volume; D014636:Valsalva Maneuver
chemical_list: D000680:Amyl Nitrite