title: Influence of genetic predisposition to diabetes and obesity on mitochondrial function.
abstract: Inbred mice with the mutation diabetes C57BL/KsJ db+/db+ and the mutation obese C57BL/6J ob/ob displayed a total liver mitochondrial capacity to oxidize glutamate or succinate which was approximately eight times greater than the capacity of the C57BL/6J +/+ control mice. This increase in oxidation capacity was estimated by multiplying the observed twofold increase in each of the following components: total liver weight, the mitochondrial protein content per gram of liver, and glutamate or succinate respiration activity per milligram of liver mitochondrial protein. No significant difference in liver mitochondrial function and capacity for oxidation was observed between db+/db+ and ob/ob mutants, which indicated that these results may be primarily mediated by the genetic factors responsible for obesity and hyperphagia in these mutants, and not by the genetic traits associated with diabetes. These findings may provide a biochemical foundation in support of the thrifty gene hypothesis.
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000235:genetics* / Q000378:metabolism; D005838:Genotype; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008930:Mitochondria, Liver / Q000378:metabolism*; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D009929:Organ Size; D010084:Oxidation-Reduction; D011506:Proteins / Q000378:metabolism; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid
chemical_list: D005971:Glutamates; D011506:Proteins; D013386:Succinates; D018698:Glutamic Acid; D019802:Succinic Acid