Thyrotropin binding inhibitor immunoglobulin. Its pathogenetic importance in hypothyroidism.
Two patients with hypothyroidism had detectable serum levels of thyrotropin binding inhibitor immunoglobulin (TBII). Patient 1 was a newborn infant who had transient neonatal hypothyroidism due to transfer of TBII from the mother with nongoitrous autoimmune thyroiditis. Patient 2 was an 8-year-old girl with Down's syndrome who presented with signs of myxedema and central precocious puberty. She had no goiter, and the recognition of thyroid disease was delayed; the histological diagnosis of chronic lymphocytic thyroiditis was established by aspiration biopsy, and TBII had strong thyroid adenyl cyclase-inhibiting activity in vitro. It appears that TBII may be pathogenetically important for occurrence of neonatal hypothyroidism and nongoitrous autoimmune thyroiditis without goiter.
D000262:Adenylyl Cyclases / Q000032:analysis; D000328:Adult; D001327:Autoimmune Diseases / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000201:enzymology / Q000209:etiology / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis*; D018828:Immunoglobulins, Thyroid-Stimulating; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000276:immunology
D007074:Immunoglobulin G; D018828:Immunoglobulins, Thyroid-Stimulating; D000262:Adenylyl Cyclases