2-Amino-7-phosphonoheptanoic acid (AP7) produces discriminative stimuli and anticonflict effects similar to diazepam.
The N-methyl-D-aspartate (NMDA) receptor antagonist, AP7, was evaluated in two animal test procedures known to be sensitive to the effects of diazepam. In rats trained to discriminate diazepam from vehicle, AP7 produced dose-dependent generalization to the diazepam interoceptive stimuli. This NMDA antagonist also increased the rates of conflict responding in a chronic test procedure used to identify compounds with potential anxiolytic effects. A comparison of AP7 with diazepam and two muscle relaxants (methocarbamol and baclofen) showed that excitatory amino acid antagonists (of the receptor site stimulated by NMDA) produce a muscle relaxant effect (drug discrimination) and may represent a new class of compounds for the treatment of anxiety-related disorders (conflict test).
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001418:Baclofen / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D008297:Male; D008721:Methocarbamol / Q000494:pharmacology; D009125:Muscle Relaxants, Central / Q000494:pharmacology; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects
D000596:Amino Acids; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D009125:Muscle Relaxants, Central; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D008721:Methocarbamol; D015763:2-Amino-5-phosphonovalerate; D001418:Baclofen; C031231:2-amino-7-phosphonoheptanoic acid; D003975:Diazepam