Polymorphic DNA marker on X chromosome and manic depression.
Heredity is an important factor in vulnerability to manic depression. A genetic linkage has been demonstrated between manic depression and coagulation factor IX at Xq27 with a TaqI polymorphism at the F9 locus in DNA samples from peripheral leucocytes of manic depressive probands and relatives in 10 informative families. Statistical analysis of the pedigrees gave a maximum lod score of 3.10 at a recombination fraction of 0.11, demonstrating a linkage between a manic depressive locus and the F9 locus in the Xq27 region.
D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics*; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis*; D005164:Factor IX / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D014960:X Chromosome
D005164:Factor IX; D004247:DNA