Phencyclidine depresses transmitter release at the neuromuscular synapse of the locust.
The presynaptic effects of phencyclidine (PCP) were studied in the locust extensor tibiae muscle. The neurally evoked transmitter release is diminished in the presence of 5 x 10(-6) to 5 x 10(-5) M PCP. This is indicated (1) by an increased coefficient of variation of the excitatory junction potentials; (2) by an increased rate of failures (a) with nerve stimulation in low [Ca2+]saline and (b) with focal extracellular stimulation in normal [Ca2+]saline. The rate of spontaneous transmitter release is not affected.
D000818:Animals; D004594:Electrophysiology; D005260:Female; D006110:Grasshoppers; D009469:Neuromuscular Junction / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009994:Osmolar Concentration; D010622:Phencyclidine / Q000494:pharmacology*; D013569:Synapses / Q000378:metabolism*; D013997:Time Factors
D018377:Neurotransmitter Agents; D010622:Phencyclidine