Sulfasalazine lung. Desensitization to sulfasalazine and treatment with acrylic coated 5-ASA and azodisalicylate.
A patient with ulcerative colitus developed fever, dyspnea, eosinophilia, and pulmonary infiltrates while taking sulfasalazine. The abnormalities resolved when the sulfasalazine was stopped but the colitus recurred. Desensitization to sulfasalazine was unsuccessful, but treatment with azodisalicylate (olsazine) controlled the colitus and did not cause pulmonary problems.
D000328:Adult; D000636:Aminosalicylic Acids / Q000627:therapeutic use*; D001989:Bronchiolitis Obliterans / Q000139:chemically induced / Q000628:therapy; D003093:Colitis, Ulcerative / Q000188:drug therapy; D003888:Desensitization, Immunologic; D006801:Humans; D008297:Male; D019804:Mesalamine; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000628:therapy; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000628:therapy; D012460:Sulfasalazine / Q000009:adverse effects*
D000636:Aminosalicylic Acids; D012460:Sulfasalazine; D019804:Mesalamine; C032587:olsalazine