title: Artificial food additive intolerance in patients with angio-oedema and urticaria.
abstract: 43 children who presented with angio-oedema and/or urticaria and who responded to an additive-free diet were challenged with artificial food additives in a double-blind study. 24 children reacted to 1 or more of the additives. 18 children did not react to any additives and remained well when a normal diet was re-introduced. Aspirin sensitivity was found in only 1 of the 24 children who could not tolerate additives. Atopy was less common in these patients than in the general population. The mechanism of additive intolerance is unknown and double-blind challenge is the only reliable means of diagnosis.
mesh_terms: D000293:Adolescent; D000799:Angioedema / Q000139:chemically induced*; D001391:Azo Compounds / Q000009:adverse effects; D001565:Benzoates / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004032:Diet; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005503:Food Additives / Q000009:adverse effects*; D005512:Food Hypersensitivity / Q000209:etiology*; D006801:Humans; D008297:Male; D012882:Skin Tests; D014581:Urticaria / Q000139:chemically induced*
chemical_list: D001391:Azo Compounds; D001565:Benzoates; D005503:Food Additives