title: Thyroxine-induced changes in rat liver mitochondrial ubiquinone.
abstract: Ubiquinone was extracted from liver mitochondria isolated from euthyroid and hyperthyroid rats. The redox state of ubiquinone was determined during States III and IV respiration with succinate or glutamate-malate substrates. Ubiquinone was more reduced during State III or IV in the hyperthyroid mitochondria with either substrate. Furthermore, the concentration of ubiquinone increased in the hyperthyroid rats.
mesh_terms: D000818:Animals; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D006980:Hyperthyroidism / Q000378:metabolism; D008293:Malates / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid; D013974:Thyroxine / Q000494:pharmacology*; D014451:Ubiquinone / Q000378:metabolism*
chemical_list: D005971:Glutamates; D008293:Malates; D013386:Succinates; D014451:Ubiquinone; D018698:Glutamic Acid; C030298:malic acid; D019802:Succinic Acid; D013974:Thyroxine