title: Spinal cord stimulation affects the central mechanisms of regulation of heart rate.
abstract: The effect of spinal cord stimulation (SCS) on heart rate (HR) was studied in 25 patients without cardiological symptoms, who were undergoing SCS for various reasons. HR at rest significantly decreased during SCS. Physiological and pharmacological maneuvers of sympathetic and parasympathetic activation or blockade before and during SCS indicate that SCS interferes with the central mechanisms of regulation of HR mainly by inducing a functional sympathectomy, and that such an effect is mediated by an action on spinal cord ascending fibers.
mesh_terms: D000328:Adult; D000368:Aged; D001285:Atropine / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D006339:Heart Rate; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D013004:Somatostatin / Q000494:pharmacology; D013116:Spinal Cord / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D004561:Transcutaneous Electric Nerve Stimulation
chemical_list: D013004:Somatostatin; D001285:Atropine; D007545:Isoproterenol