The prevalence of Entamoeba histolytica in lactating women and in their infants in Bangladesh.
Entamoeba histolytica was studied in 33 lactating women and their infants in a periurban village in Bangladesh. Infant-mother pairs were followed for a period of 10-15 months: 67% of mothers excreted E. histolytica during the observation period, the majority for 3 months or more. Only one mother was symptomatic, with a mild, non-dysenteric diarrhoea. 58% of mothers were seropositive, several of them continuously and with a high titre, indicating past invasive infection. 67% had detectable antibodies in breast milk and 36% in saliva. Despite the high prevalence of E. histolytica in these mothers, infants were mostly uninfected: E. histolytica cysts in small numbers were found in only 2 of 1200 samples from infants aged 6 and 10 months. Several of the children were infected with Giardia lamblia. Although lower exposure to E. histolytica than to Giardia may account for the difference in infant infection rates with these parasites, defence mechanisms possibly exist which protect against E. histolytica but are ineffective against Giardia.
D000293:Adolescent; D000328:Adult; D000562:Amebiasis / Q000453:epidemiology*; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D001459:Bangladesh; D004748:Entamoeba histolytica / Q000276:immunology / Q000302:isolation & purification; D004749:Entamoebiasis / Q000453:epidemiology*; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D007774:Lactation; D008895:Milk, Human / Q000276:immunology; D011247:Pregnancy; D012463:Saliva / Q000276:immunology
D000913:Antibodies, Protozoan; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G