title: Hyperphosphataemia in histamine injected laying hens.
abstract: The effects of histamine on soluble calcium concentrations in gastrointestinal tract contents, acid secretion, urinary phosphorus excretion, plasma free-hydroxyproline and inorganic phosphorus levels were studied in laying hens during egg shell formation. Histamine induced hyperphosphataemia, hyperhydroxyprolinemia and decreased soluble gastrointestinal calcium at 3 hr after injection. Cimetidine inhibited all effects induced by histamine. This suggests that hyperphosphataemia arises from increased bone resorption provoked by decreased soluble intestinal calcium during egg shell formation.
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002645:Chickens / Q000502:physiology*; D002927:Cimetidine / Q000494:pharmacology; D005753:Gastric Mucosa / Q000378:metabolism; D005895:Gizzard, Avian / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology*; D006909:Hydroxyproline / Q000097:blood; D007421:Intestine, Small / Q000378:metabolism; D010710:Phosphates / Q000097:blood*; D010758:Phosphorus / Q000652:urine
chemical_list: D010710:Phosphates; D010758:Phosphorus; D002927:Cimetidine; D006632:Histamine; D006909:Hydroxyproline; D002118:Calcium