[alpha-Aminomethylketones as inhibitors of a membrane-bound alanine aminopeptidase].
Methyl ketone derivatives of L-amino acids are substrate analogous inhibitors of membrane bound alanine aminopeptidase (EC 3.4.11.2) from Acinetobacter calcoaceticus. The type of inhibition is competitive. Compounds with a branched aliphatic side chain are most effective so that valine methyl ketone was found to be the best inhibitor of the enzyme with a K-value of 5.5.10(-7) mol.l-1.
D000150:Acinetobacter / Q000201:enzymology; D000626:Aminopeptidases / Q000037:antagonists & inhibitors*; D018826:CD13 Antigens; D007659:Ketones / Q000494:pharmacology*; D007700:Kinetics; D008566:Membranes / Q000201:enzymology; D013329:Structure-Activity Relationship
D007659:Ketones; D000626:Aminopeptidases; D018826:CD13 Antigens
alpha-Aminomethylketone als Inhibitoren einer membrangebundenen Alanin-aminopeptidase.