Dopaminergic nigrotectal projection in the rat.
After injecting a fluorescent tracer (Fluoro-gold) into the rat superior colliculus, retrogradely labeled neurons in the rostral, ventrolateral portions of the substantia nigra pars reticulata were also immunohistochemically labeled with tyrosine hydroxylase antisera. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) pretreatment of the medial forebrain bundle resulted in the disappearance of the nigral neurons double-labeled with the two markers. The existence of a dopaminergic nigrotectal projection susceptible to MPTP might provide a morphological substrate for abnormal saccadic eye movements in parkinsonism.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D005456:Fluorescent Dyes; D007150:Immunohistochemistry; D008297:Male; D008474:Medial Forebrain Bundle / Q000187:drug effects / Q000378:metabolism; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013266:Stilbamidines; D013378:Substantia Nigra / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013477:Superior Colliculi / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D014795:Visual Pathways / Q000033:anatomy & histology / Q000378:metabolism*
C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D005456:Fluorescent Dyes; D011725:Pyridines; D013266:Stilbamidines; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine