title: Excitatory amino acid antagonists depress transmission in hippocampal projections to the lateral septum.
abstract: Antagonists of excitatory amino acid neurotransmission were tested as antagonists of septal excitatory postsynaptic potentials (EPSPs) generated by stimulation of the fimbria. Septal EPSPs were depressed in a concentration-dependent manner by kynurenic acid and P-bromobenzoyl piperazine-2,3-dicarboxylic acid but not by L-2-amino-4-phosphonobutyric acid or D-2-amino-5-phosphonopentanoic acid. These results indicate that the hippocampal projection to the lateral septum is similar to the Schaffer collateral system and is mediated by an excitatory amino acid or a similar derivative.
mesh_terms: D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D000596:Amino Acids; D018377:Neurotransmitter Agents