Demonstration of a thymus cell tumour in BLV-infected cattle.
Occurrence of thymus cell tumours was followed in cattle with enzootic leukosis using a thymus-specific antiserum. Among 32 tumorous lymph nodes investigated, one could be identified as a thymus cell tumour. In the DNA extract from this tumorous lymph node BLV-specific sequences have been demonstrated. This finding disproved the hitherto assumption that BLV-induced lymph node tumours of cattle were derived exclusively from B-lymphocytes.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis*; D002417:Cattle; D002462:Cell Membrane / Q000276:immunology; D004279:DNA, Viral / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D007074:Immunoglobulin G / Q000032:analysis; D001909:Leukemia Virus, Bovine / Q000235:genetics / Q000276:immunology; D007942:Leukemia, Experimental / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D008198:Lymph Nodes / Q000276:immunology* / Q000648:ultrastructure; D008562:Membrane Glycoproteins; D009693:Nucleic Acid Hybridization; D013601:T-Lymphocytes / Q000276:immunology
D000951:Antigens, Neoplasm; D004279:DNA, Viral; D007074:Immunoglobulin G; D008562:Membrane Glycoproteins; C028388:thymus-leukemia antigens