Induction and promotion of gamma-glutamyltranspeptidase-positive foci in the rat liver by methylglyoxal.
The effect of pre-(initiation) and post-(promotion) administration of methylglyoxal (MG) on the induction of gamma-glutamyltranspeptidase (GGT)-positive foci in the liver of F344 male rats was investigated. GGT-positive foci were produced in dose-related amounts by 0.05 and 0.2% MG in drinking water, either when administered to uninitiated rats or when given in the promotion phase.
D015073:2-Acetylaminofluorene; D000447:Aldehydes / Q000633:toxicity*; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000201:enzymology; D008297:Male; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000201:enzymology; D011765:Pyruvaldehyde / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D005723:gamma-Glutamyltransferase / Q000032:analysis*
D000447:Aldehydes; D011765:Pyruvaldehyde; D015073:2-Acetylaminofluorene; D002251:Carbon Tetrachloride; D005723:gamma-Glutamyltransferase