title: Terfenadine and brompheniramine maleate in urticaria and dermographism.
abstract: The effects of brompheniramine maleate (12 mg twice daily in sustained release form) and terfenadine (60 mg twice daily) on the symptoms and well-being of 16 adults with urticaria with or without dermographism were assessed by symptom questionnaire. Following an initial 2-week period without therapy, each drug was taken for 2 weeks in a randomised double-blind cross-over study. Both drugs produced significant relief of itch and rash but only brompheniramine produced significant drowsiness. Brompheniramine maleate was more effective than terfenadine in the patients with dermographism.
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D001977:Brompheniramine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D011725:Pyridines / Q000627:therapeutic use*; D011897:Random Allocation; D016593:Terfenadine; D014581:Urticaria / Q000188:drug therapy*
chemical_list: D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D011725:Pyridines; D016593:Terfenadine; D001977:Brompheniramine