[Analysis of the influence of anxiolytics on the pain reactions of rats compared to the effect of morphine].
Anxiolytic agents, buspirone and diazepam, increase the paw lick latency of rats in hot plate test, the effect being dose-dependent and exceeding that of morphine. The action of buspirone was not accompanied by ataxic and sedative effects which were observed in rats on diazepam. Buspirone (up to 25 mg/kg) and diazepam (up to 5 mg/kg) neither change the tail flick latency nor potentiate the action of morphine in this test. The effect of buspirone on the paw lick reaction in rats may be related to the inhibition of emotional-motivation component of pain reaction.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D002065:Buspirone; D003975:Diazepam / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D008297:Male; D009020:Morphine / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D011743:Pyrimidines / Q000627:therapeutic use; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D014151:Anti-Anxiety Agents; D011743:Pyrimidines; D009020:Morphine; D003975:Diazepam; D002065:Buspirone
Analiz vliianiia anksiolitikov na bolevye reaktsii u krys v sravnenii s éffektom morfina.