title: Plasma immunoreactive calcitonin in the frog (Rana pipiens).
abstract: 1. Plasma immunoreactive calcitonin (iCT) and ionic calcium [( Ca]i) were measured in intact frogs (Rana pipiens) within complete 24 hr light-dark cycles over an 18 month period. 2. Plasma iCT exhibits an annual periodicity about the annual mean of 10.0 ng/ml, with an amplitude of 5.4 ng/ml that peaks in October. 3. Within an annual cycle, a significant inverse association exists between the basal monthly levels of plasma iCT and [Ca]i for animals maintained in freshwater control conditions. 4. When subjected to a high calcium environment during the latter half of the year, plasma [Ca]i and iCT were elevated above control levels but exhibited independent cyclic patterns. 5. A distinct seasonal response of increased iCT in a high calcium environment may be related to the secretory activity of the ultimobranchial glands and physiological responsiveness to other calcemic hormones; e.g. parathyroid hormone and vitamin D.
mesh_terms: D000818:Animals; D002116:Calcitonin / Q000097:blood*; D002118:Calcium / Q000097:blood; D008297:Male; D011894:Rana pipiens / Q000097:blood*; D012016:Reference Values
chemical_list: D002116:Calcitonin; D002118:Calcium