Transmission of human T cell lymphotropic virus type I by blood transfusion before and after mass screening of sera from seropositive donors.
The human T cell lymphotropic virus type I (HTLV-I) is transmitted by blood transfusions that contain cell components as one of the virus transmission modes. We carried out mass screening of sera from seropositive donors by a gelatin particle agglutination test to prevent the spread of HTLV-I by transfusion. Seroconversion rates were compared before and after screening. The results show a remarkable decrease in the rate of infection from 53.6 to 0.9%. Therefore, it is certain that screening by the agglutination method prevents the spread of HTLV-I transmission in blood transfusions.
D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis; D001782:Blood Donors; D017977:Deltaretrovirus / Q000276:immunology / Q000302:isolation & purification; D006800:Deltaretrovirus Infections / Q000097:blood / Q000276:immunology / Q000635:transmission*; D006801:Humans; D008403:Mass Screening; D065227:Transfusion Reaction
D000914:Antibodies, Viral