The scavenging of oxidants by sulphasalazine and its metabolites. A possible contribution to their anti-inflammatory effects?
Sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5-aminosalicylate are powerful scavengers of the hydroxyl radical, determined by pulse radiolysis and confirmed by assays based on deoxyribose degradation by hydroxyl radicals. 5-Aminosalicylate can also protect alpha 1-antiprotease against attack by the myeloperoxidase-derived oxidant hypochlorous acid. The ability to scavenge oxidants produced at sites of inflammation may contribute to the anti-inflammatory action of sulphasalazine and its metabolites.
D000636:Aminosalicylic Acids / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D006878:Hydroxides; D017665:Hydroxyl Radical; D006997:Hypochlorous Acid / Q000494:pharmacology; D019804:Mesalamine; D010084:Oxidation-Reduction; D013424:Sulfanilamides / Q000494:pharmacology*; D013427:Sulfapyridine / Q000494:pharmacology*; D012460:Sulfasalazine / Q000494:pharmacology*
D000636:Aminosalicylic Acids; D000893:Anti-Inflammatory Agents; D006878:Hydroxides; D013424:Sulfanilamides; D017665:Hydroxyl Radical; D012460:Sulfasalazine; D019804:Mesalamine; D006997:Hypochlorous Acid; D013427:Sulfapyridine