Flavonoids, leucocyte migration and eicosanoids.
Quercetin reduced the concentration of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in the pleural exudate induced in rats by 1% carrageenan given intrapleurally. Leucocyte migration in the exudate was also reduced by the flavonoid. Inhibition of eicosanoids and leucocytes in the exudate was dose-related. Quercetin also reduced LTB4 synthesis in cells stimulated with ionophore A23187, either ex-vivo or in-vitro. A similar, though less active, mode of action was found with quercitrin, while apigenin and luteolin reduced leucocyte accumulation and PGE2 formation, but not LTB4-formation.
D000818:Animals; D002465:Cell Movement; D015232:Dinoprostone; D005419:Flavonoids / Q000494:pharmacology*; D007962:Leukocytes / Q000276:immunology*; D007975:Leukotriene B4 / Q000096:biosynthesis*; D008297:Male; D010996:Pleural Effusion / Q000276:immunology* / Q000378:metabolism; D011458:Prostaglandins E / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D005419:Flavonoids; D011458:Prostaglandins E; D007975:Leukotriene B4; D015232:Dinoprostone