Properties of amiodarone monolayer spread at the air-water interface.
Surface pressure measurements demonstrate that, over a wide range of pH, amiodarone forms a stable monolayer at the air-water interface. The area found to be occupied by an amiodarone molecule was compared with a theoretical prediction based on a conformational analysis, making it possible to assemble amphiphilic molecules. The intrinsic ionization constant of amiodarone in an aqueous environment pKi = 8.7 +/- 0.5 was evaluated from surface potential measurements.
D000388:Air; D000638:Amiodarone; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D008968:Molecular Conformation; D013499:Surface Properties; D014867:Water
D014867:Water; D000638:Amiodarone