title: The influence of chlormethiazole in comparison to thioridazine on body temperature and postural hypotension in healthy adults and healthy elderly volunteers.
abstract: Certain drugs used to treat the elderly are known to precipitate hypothermia. In this study, the effects of chlormethiazole and thioridazine in producing postural hypotension were compared. In a study of hypothermia in the elderly the effects of chlormethiazole, thioridazine and lormetazepam were examined. Only three patients showed a postural drop following chlormethiazole, while 11 showed a postural drop following thioridazine. Chlormethiazole showed little variation from the control group in the hypothermia study, while thioridazine and lormetazepam caused a fall in temperature. For behaviour control in the elderly and for a short course as a hypnotic, chlormethiazole seems to be safer than thioridazine or lormetazepam.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001569:Benzodiazepines; D001794:Blood Pressure / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects*; D002719:Chlormethiazole / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D011187:Posture; D012881:Skin Temperature / Q000187:drug effects; D013881:Thioridazine / Q000494:pharmacology*
chemical_list: D014151:Anti-Anxiety Agents; D002719:Chlormethiazole; D001569:Benzodiazepines; C023842:lormetazepam; D013881:Thioridazine; D008140:Lorazepam