Seizures following triazolam withdrawal despite benzodiazepine treatment.
The authors report a case of a 55-year-old man undergoing a triazolam withdrawal syndrome that was recognized and treated with high doses of benzodiazepines, but the patient nevertheless developed seizures. Reasons for the occurrence of these seizures despite treatment are discussed within the context of the differential potency that exists among benzodiazepines in binding to central and peripheral benzodiazepine receptors.
D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy; D002707:Chlordiazepoxide / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011963:Receptors, GABA-A / Q000378:metabolism; D012640:Seizures / Q000139:chemically induced* / Q000517:prevention & control; D013375:Substance Withdrawal Syndrome / Q000209:etiology* / Q000517:prevention & control; D014229:Triazolam / Q000009:adverse effects*
D014151:Anti-Anxiety Agents; D011963:Receptors, GABA-A; D014229:Triazolam; D002707:Chlordiazepoxide; D003975:Diazepam