Cerebral blood flow and antihypertensive treatment with enalapril.
The intravenous 133Xenon method was used to measure regional cerebral blood flow (rCBF) in 20 patients with moderate hypertension. Regional cerebral blood flow under pretreatment, in the placebo period and after 8 weeks of enalapril treatment were compared. The rCBF values [(F1), and initial slope, (IS)] showed no statistical difference during the three periods in spite of significantly higher blood pressure values in the placebo period. It is concluded, that with enalapril good blood pressure control is achieved without any adverse effect on rCBF.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology; D004656:Enalapril / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D004232:Diuretics; D004656:Enalapril