Sequential expression of OX2 and Thy-1 glycoproteins on the neuronal surface during development. An immunohistochemical study of rat cerebellum.
The related neuronal surface glycoproteins, Thy-1 and OX2, are shown here to have a reciprocal pattern of expression during development in rat cerebellum. OX2 appears at axonogenesis, on neuronal cell bodies and their axons. Immunohistochemical staining for this molecule then gradually wanes, and over the same period the cells acquire their first, weak staining for Thy-1. Intense Thy-1 expression occurs during the period of dendritic growth.
D000818:Animals; D015703:Antigens, CD; D000954:Antigens, Surface / Q000378:metabolism*; D002454:Cell Differentiation; D002531:Cerebellum / Q000166:cytology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D006651:Histocytochemistry; D007124:Immunoenzyme Techniques; D008565:Membrane Proteins / Q000096:biosynthesis*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D051381:Rats; D018800:Thy-1 Antigens; D013997:Time Factors
D015703:Antigens, CD; D000954:Antigens, Surface; D008565:Membrane Proteins; D018800:Thy-1 Antigens; C042739:antigens, CD200