[Temperature sensitivity of afferent receptors in the isolated rabbit heart].
Changes in the positive chronotropic effects induced by epicardial irrigation with heated Krebs-Henseleit solution were studied in the isolated rabbit heart before and after intracoronary infusion of a ganglionic blocking agent, Arfonad (10 mg/ml). 2-3 minutes after Arfonad infusion the positive chronotropic effects decreased to 37.9% and 5-10 minutes later they returned to control levels. It is concluded that epicardial surface warming causes an increase in afferent receptor activity. It is suggested that neurogenic component of the positive chronotropic effect may be produced through the activation of intracardiac reflectory pathways.
D000818:Animals; D005730:Ganglionic Blockers / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000294:innervation*; D006339:Heart Rate; D006358:Hot Temperature; D066298:In Vitro Techniques; D009475:Neurons, Afferent / Q000502:physiology*; D011817:Rabbits; D014294:Trimethaphan / Q000494:pharmacology*
D005730:Ganglionic Blockers; D014294:Trimethaphan; C017774:trimethaphan camsylate
Temperaturnaia chuvstvitel'nost' afferentnykh retseptorov izolirovannogo serdtsa krolika.