The effect of levobunolol on aqueous humor dynamics.
We evaluated the acute effects of installation of 0.5% levobunolol on aqueous humor dynamics in a double-masked study in 18 patients with ocular hypertension. Aqueous flow was measured by fluorophotometry and total outflow facility by tonography. Aqueous flow decreased approximately 29% in the eyes treated with levobunolol. Total outflow facility and episcleral venous pressure measurements were similar in levobunolol-treated eyes and contralateral eyes treated with vehicle. A 36% decrease in intraocular pressure was observed in the levobunolol-treated eyes and a slight intraocular pressure reduction was seen in the vehicle-treated eyes. The results of this study indicate that, similar to timolol, levobunolol lowers intraocular pressure primarily by decreasing aqueous humour production.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D001082:Aqueous Humor / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D002040:Levobunolol / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000503:physiopathology*; D013237:Stereoisomerism; D014690:Venous Pressure / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D002040:Levobunolol