Unchanged expression of Epstein-Barr virus-determined nuclear antigen-1 in productive virus cycle.
The level of the Epstein-Barr virus (EBV)-determined nuclear antigen (EBNA-1) encoded by the Bam HI-K fragment of EBV DNA remained unchanged in P3HR-1 cells after induction of the productive cycle of virus replication by sodium-n-butyrate and 12-o-tetradecanoylphorbol-13-acetate (TPA). This was shown by the same capacity of cell-free extracts from untreated and treated P3HR-1 cells to absorb anti-EBNA-1 antibody from a known human serum.
D000956:Antigens, Viral / Q000032:analysis* / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D019309:Epstein-Barr Virus Nuclear Antigens; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D006801:Humans; D014407:Tumor Cells, Cultured / Q000276:immunology / Q000382:microbiology; D014779:Virus Replication
D000956:Antigens, Viral; D004279:DNA, Viral; D019309:Epstein-Barr Virus Nuclear Antigens