title: [Thyrotropin-displacing antibodies in thyroid gland diseases].
abstract: Thyroid-stimulating antibodies were assayed in 798 patients with thyroid diseases and 122 controls by means of a heterologous radioreceptor assay as thyrotropin displacement activity (TDA). With an intraassay variance of 5-6% and an interassay variance of 8-13% in higher TDA values, test results were well reproducible. Thus, TDA assay is suitable for routine testing and follow-up of titers in the upper range. With only few exceptions TDA values of F greater than or equal to 11% are found exclusively in Graves' disease (sensitivity 39.2%; specificity vs other thyroid diseases 99.7%). In patients with functional autonomy in nodular goitre (Plummer's disease) TDA is consistently negative. TDA measurement is a valuable means for the detection of Graves' disease and for differential diagnosis of hyperthyroidism of undetermined pathogenesis.
mesh_terms: D000906:Antibodies / Q000276:immunology; D005260:Female; D006111:Graves Disease / Q000276:immunology; D006801:Humans; D006980:Hyperthyroidism / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology*; D018828:Immunoglobulins, Thyroid-Stimulating; D008297:Male; D013959:Thyroid Diseases / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000276:immunology; D013972:Thyrotropin / Q000276:immunology*
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G; D018828:Immunoglobulins, Thyroid-Stimulating; D013972:Thyrotropin
vernacular_title: Thyreotropin-verdrängende Antikörper (TDA) bei Schilddrüsenerkrankungen.