Alterations in serum gastrin levels and antral G- and D-cell population following corticosteroid administration. RIA and immunocytochemical long-term study in guinea pigs.
Fourteen guinea pigs were given prednisolone daily for 20 days and 11 for 40 days. Another 20 formed the two control groups. Short-term prednisolone treatment significantly increased serum gastrin levels and antral G-cell population as compared to the control group. The same parameters significantly decreased following 40 days of prednisolone treatment as compared to the group of short-term prednisolone treatment. Forty days of prednisolone treatment significantly increased antral D-cell population as compared to the control and short-term prednisolone treatment groups. It is concluded that hypergastrinaemia and antral G-cell hyperplasia following corticosteroid administration is temporary and is accompanied by antral D-cell hyperplasia.
D000818:Animals; D002452:Cell Count; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects*; D005755:Gastrins / Q000097:blood* / Q000378:metabolism; D006168:Guinea Pigs; D007124:Immunoenzyme Techniques; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D011706:Pyloric Antrum / Q000166:cytology* / Q000378:metabolism; D011863:Radioimmunoassay; D013004:Somatostatin / Q000378:metabolism*; D013997:Time Factors
D005755:Gastrins; D013004:Somatostatin; D011239:Prednisolone