title: Multiple malignant rectal carcinoid tumors with immunocytochemical demonstration of multiple hormonal substances.
abstract: This case report deals with a patient who presented with 17 small carcinoid tumors of the rectum, the largest measuring less than 1 cm in diameter. After a review of the literature on this subject, this case is believed to be highly unusual in several respects: (1) despite their small size, these tumors resulted in multiple metastases to the regional lymph nodes; (2) both primary tumors and metastases were extensively and strongly argentaffin; and (3) most tumors and metastases contained, when investigated by immunocytochemistry, several biologically active substances such as serotonin, somatostatin, and glucagon-like immunoreactivity.
mesh_terms: D002276:Carcinoid Tumor / Q000378:metabolism / Q000473:pathology*; D005934:Glucagon / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012004:Rectal Neoplasms / Q000378:metabolism / Q000473:pathology*; D012007:Rectum / Q000473:pathology*; D012701:Serotonin / Q000032:analysis; D013004:Somatostatin / Q000032:analysis
chemical_list: D012701:Serotonin; D013004:Somatostatin; D005934:Glucagon