Islet-cell antibodies and insulin autoantibodies in association with common viral infections.
The appearance of islet-cell antibodies (ICA) and insulin autoantibodies (IAA) was sought in a prospective study of subjects with acute infections (mumps, rubella, chickenpox, and measles) followed for 6 months. IAA appeared in many patients' serum samples after these acute infections, IgM-IAA being more prevalent than IgG-IAA; there was a particularly high incidence (81%) after chickenpox. ICA were detected in 2 subjects--in 1 after rubella and in the other after measles, but this patient had evidence of previous rubella and a strong autoimmune family history. ICA did not appear after mumps. It is postulated that viral infections may trigger the production of IgM-IAA by a common mechanism involving polyclonal immunocyte activation.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000906:Antibodies / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D002644:Chickenpox / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D007330:Insulin Antibodies / Q000032:analysis*; D007515:Islets of Langerhans / Q000276:immunology*; D008297:Male; D008457:Measles / Q000276:immunology; D009107:Mumps / Q000276:immunology; D011446:Prospective Studies; D012409:Rubella / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*
D000906:Antibodies; D001323:Autoantibodies; D007330:Insulin Antibodies