Oestrogen-induced expression of oncogenes in the immature rat uterus.
4 h after a single precocious administration of oestrogen there was a considerable but short-lived surge in the uterine levels of myc-encoded polyadenylated mRNA. This was followed by a further peak 28 h after hormone administration. The expression of rasHa showed a totally different time course with a build up of hybridizable message that peaked 8 h after oestrogen administration.
D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D009857:Oncogenes / Q000187:drug effects*; D011061:Poly A / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D051381:Rats; D012741:Sexual Maturation; D014158:Transcription, Genetic / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D012333:RNA, Messenger; D011061:Poly A; D004958:Estradiol