[Modification of orocecal transit time of salazosulfapyridine by atropine and metoclopramide in healthy probands].
The first appearance of sulpharyridine in plasma was investigated in nine healthy informed male volunteers. In a three way crossover design 6 g salazopyrin alone, together with metoclopramide (0.3 mg/kg i.m.) or atropine (0.01 mg/kg i.m.) were given. Sulphapyridine appears in the blood at the (means +/- S means) 6.2 h +/- 0.8 h (range: 3-11 h) in controls. Together with metoclopramide the first appearance is 3.6 h +/- 0.7 h (range: 2-8 h) and together with atropine these values are 8.1 +/- 0.8 h (range: 6-12 h). The differences are significant with p less than 0.05. The results show the pharmacological modification of motility in the gastrointestinal tract and in consequence the usefulness of salazopyridine to determine the transit time.
D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D012460:Sulfasalazine / Q000378:metabolism*
D012460:Sulfasalazine; D001285:Atropine; D008787:Metoclopramide
Die Modifikation der oro-caecalen Transitzeit von Salazosulfapyridin durch Atropin und Metoclopramid am gesunden Probanden.