Effects of calcium channel antagonists and other antihypertensive drugs on atherogenesis.
This paper reviews published data concerning the effects of antihypertensive drugs on the development of atherosclerosis in experimental animal models with hyperlipoproteinaemia. Emphasis is placed on the influence of calcium channel antagonists on this process, and the potential mechanisms responsible for the effect. In addition, studies of the action of beta-receptor antagonists on atherogenesis are also summarized. The results indicate that several antihypertensive drugs may inhibit or retard experimentally-induced atherogenesis, even in normotensive animals, although the mechanisms for the effects remain poorly understood.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001158:Arteries / Q000187:drug effects / Q000378:metabolism; D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D008074:Lipoproteins; D002118:Calcium