title: The development of a new antihistamine: astemizole.
abstract: As compared with reference antihistamines, the action of astemizole is characterized by several unusual properties: highly pronounced and very specific histamine H1 antagonism, long duration of action and absence of central and sedative effects.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D016589:Astemizole; D001562:Benzimidazoles / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D003233:Conjunctivitis, Allergic / Q000188:drug therapy; D006634:Histamine H1 Antagonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D051381:Rats; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy; D014581:Urticaria / Q000188:drug therapy
chemical_list: D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D016589:Astemizole