title: Evidence for a migratory capability of rat Kupffer cells to portal tracts and hepatic lymph nodes.
abstract: The present study concerns the migratory ability of Kupffer cells in the rat. Phagocytic cells were labeled with colloidal carbon or gold, these markers being administered intravenously either into a tail vein, which resulted in generalized reticuloendothelial uptake, or in low dose into the portal vein, which produced uptake by Kupffer cells alone. Cells containing marker were observed in the portal tracts and in hepatic lymph nodes from 1 to 3 days after injection into the portal vein. The direct movement of single marker particles to the portal tracts could be excluded. Since injection of marker into the portal vein labeled Kupffer cells exclusively, whereas blood cells, splenic and bone marrow macrophages remained unlabeled, the labeled cells in the portal tracts and hepatic lymph nodes appeared to be former Kupffer cells migrating which had migrated to these sites.
mesh_terms: D000818:Animals; D007728:Kupffer Cells / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D008099:Liver / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D008198:Lymph Nodes / Q000502:physiology*; D008264:Macrophages / Q000502:physiology; D008297:Male; D008854:Microscopy, Electron; D010587:Phagocytosis; D051381:Rats; D011919:Rats, Inbred Strains; D013156:Splenectomy