New aspects of metabolic conjugation of chloramphenicol.
New and major chloramphenicol (CP) metabolites have been isolated from the urine of goats administered [3H]CP. The CP-3-sulfoconjugate has been identified formally from its chromatographic behaviour and mass spectrometric analysis, as well as from incubations of CP with liver cytosol, using synthetic CP-conjugate as reference. Only a strong assumption is made of the identity of the CP-3-phosphoconjugate.
D000818:Animals; D002701:Chloramphenicol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D003600:Cytosol / Q000378:metabolism; D006041:Goats; D008099:Liver / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D051381:Rats; D013431:Sulfates / Q000378:metabolism
D010710:Phosphates; D013431:Sulfates; D002701:Chloramphenicol