Comparison of single doses of ketanserin and placebo in chronic stable angina.
Single doses of ketanserin (20 or 40 mg) and placebo were compared in a double-blind cross-over study in 10 patients with chronic stable angina treated with a beta-adrenoceptor antagonist. Ketanserin had no significant effect on the exercise time to angina, the rate of ST segment depression, or the circulatory response to exercise. The 95% confidence limits indicate that ketanserin is unlikely to increase exercise time to angina by more than 20%.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007650:Ketanserin; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D010880:Piperidines; D007650:Ketanserin