Neuropeptide Y in multiple endocrine neoplasia: release during surgery for phaeochromocytoma.
High plasma concentrations of neuropeptide Y (NPY) were found in a patient with bilateral adrenal phaeochromocytomas and medullary thyroid carcinoma associated with MEN IIa (32 pmol/l, normal less than 3.5 pmol/l). Both adrenal tumours contained and secreted NPY. Manipulation at operation produced a remarkable increase in plasma NPY concentrations (peak = 1631 pmol/l) coinciding with increases in plasma levels of catecholamines and arterial pressure. NPY was also shown to be present in thyroid tumour tissue: the concentration of NPY in tumour was 50-fold higher (0.9 nmol/g vs 0.004 nmol/g) than in adjacent normal thyroid tissue. It is possible that NPY from some phaeochromocytomas may contribute to hypertension during surgery.
D000310:Adrenal Gland Neoplasms / Q000097:blood* / Q000601:surgery; D004837:Epinephrine / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000097:blood* / Q000601:surgery; D009478:Neuropeptide Y / Q000097:blood*; D009638:Norepinephrine / Q000097:blood; D010673:Pheochromocytoma / Q000097:blood* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000097:blood* / Q000601:surgery
D009478:Neuropeptide Y; D009638:Norepinephrine; D004837:Epinephrine