Tropical spastic paraparesis in Colombia.
A high-incidence focus of tropical spastic paraparesis (TSP) occurs on the South Pacific coast of Colombia. Of 55 patients studied, 52 (94.5%) had IgG antibodies to the human T-cell lymphotropic virus type I (HTLV-I) in serum and/or cerebrospinal fluid. Control groups did not show similar high positivity. Our results suggest that HTLV-I or other antigenically related retroviruses may be the cause of TSP in Colombia. Similar clinical, laboratory, and epidemiological findings have been reported in widely remote geographical regions of the world, with very similar clinical pictures of TSP in all high-incidence regions. The demonstration of IgG antibodies in serum and cerebrospinal fluid of patients with TSP in the Caribbean and Seychelles Islands, southern Japan, and the Ivory Coast indicate that the HTLV-I retrovirus could be the cause of this "tropical" myeloneuropathy.
D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis / Q000134:cerebrospinal fluid; D000914:Antibodies, Viral / Q000032:analysis* / Q000138:chemical synthesis; D003105:Colombia; D015480:Deltaretrovirus Antibodies; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis / Q000134:cerebrospinal fluid; D007525:Isoelectric Focusing; D008297:Male; D009128:Muscle Spasticity / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000276:immunology; D043025:Oligoclonal Bands; D010264:Paraplegia / Q000134:cerebrospinal fluid / Q000453:epidemiology* / Q000276:immunology; D014330:Tropical Medicine
D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral; D015480:Deltaretrovirus Antibodies; D007074:Immunoglobulin G; D007136:Immunoglobulins; D043025:Oligoclonal Bands