Piracy of adhesins: attachment of superinfecting pathogens to respiratory cilia by secreted adhesins of Bordetella pertussis.
Two proteins secreted by Bordetella pertussis are known to mediate adherence of these bacteria to mammalian respiratory cilia. When either ciliated cells or other pathogenic bacteria were pretreated with these adhesins, Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus acquired the ability to adhere to cilia in vitro and in vivo. Such piracy of adhesins may contribute to superinfection in mucosal diseases such as whooping cough.
D000818:Animals; D001422:Bacterial Adhesion; D001886:Bordetella pertussis / Q000472:pathogenicity*; D002923:Cilia / Q000382:microbiology; D006193:Haemophilus influenzae / Q000472:pathogenicity; D006388:Hemagglutinins / Q000502:physiology; D066298:In Vitro Techniques; D011817:Rabbits; D012137:Respiratory System / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000472:pathogenicity; D013296:Streptococcus pneumoniae / Q000472:pathogenicity; D010566:Virulence Factors, Bordetella / Q000502:physiology
D006388:Hemagglutinins; D010566:Virulence Factors, Bordetella