Changes of the liver UDP-glucuronosyltransferase activity in trout (Salmo gairdneri Rich.) acutely exposed to selected aquatic toxicants.
Rainbow trout were exposed for 4 or 8 days to various types of toxicants, each applied to the test water at a high sublethal concentration. The activity of liver UDP-glucuronosyltransferase (UDP-GT) was assayed from the submitochondrial fraction using p-nitrophenol as an aglycone. Activity of UDP-GT was inhibited by 2,4,6-trichlorophenol, pentachlorophenol and dehydroabietic acid, all toxicants regularly found in effluents of the pulp and paper industry. The heavy metals cadmium and zinc, the polychlorinated biphenyl, Pyralene 3010, and chloroform did not affect UDP-GT activity. The slimicide N-methyl-dithiocarbamate (Vapam) significantly increased the enzyme activity.
D045784:Abietanes; D000818:Animals; D002104:Cadmium / Q000494:pharmacology; D002725:Chloroform / Q000494:pharmacology; D002733:Chlorophenols / Q000494:pharmacology; D004224:Diterpenes / Q000494:pharmacology; D014453:Glucuronosyltransferase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D010416:Pentachlorophenol / Q000494:pharmacology; D012487:Salmonidae / Q000378:metabolism*; D013859:Thiocarbamates / Q000494:pharmacology; D014337:Trout / Q000378:metabolism*; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015032:Zinc / Q000494:pharmacology
D045784:Abietanes; D002733:Chlorophenols; D004224:Diterpenes; D013859:Thiocarbamates; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D002104:Cadmium; C013913:dehydroabietic acid; C008435:methyldithiocarbamate; D002725:Chloroform; D010416:Pentachlorophenol; D014453:Glucuronosyltransferase; D015032:Zinc; C024564:2,4,6-trichlorophenol