title: Regulation of growth hormone secretion. Relevance to the pediatrician.
abstract: The regulation of human growth hormone secretion is complex involving both a hypothalamic stimulating and inhibiting hormone. These neurohormones are further regulated by neurotransmitters. Abnormalities in growth hormone secretion may occur in neurologic, psychiatric and metabolic disorders not related to short stature. In addition, the diagnosis of deficiency states of growth hormone secretion can often be very difficult. Guidelines for the work-up of short children are given.
mesh_terms: D005260:Female; D006128:Growth; D006130:Growth Disorders / Q000503:physiopathology; D013006:Growth Hormone / Q000172:deficiency / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000502:physiology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D008297:Male; D008659:Metabolic Diseases / Q000503:physiopathology; D009490:Neurosecretory Systems / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000502:physiology*; D013004:Somatostatin / Q000502:physiology
chemical_list: D018377:Neurotransmitter Agents; D013004:Somatostatin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone