[Ganglionic synapses of Aplysia as a model for the study of the mechanism of action of botulinum neurotoxins].
The action of type A and type B botulinum neurotoxin on neurotransmitter release was studied on identified ganglionic synapses of Aplysia. Using this model, we have shown that botulinum neurotoxins at concentrations used in vertebrate preparations had the same specificity of action and that both heavy and light chains of these toxins are intracellularly required to inhibit neurotransmitter release.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001048:Aplysia; D001905:Botulinum Toxins / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D005724:Ganglia / Q000187:drug effects*; D008970:Molecular Weight; D018377:Neurotransmitter Agents / Q000378:metabolism; D013569:Synapses / Q000187:drug effects* / Q000378:metabolism
D018377:Neurotransmitter Agents; D001905:Botulinum Toxins
Les synapses ganglionnaires d'Aplysie comme modèle d'étude du mode d'action des neurotoxines botuliques.