An aspect of the organizational principle of the gamma-aminobutyric acidergic system in the cerebral cortex.
The possibility of the colocalization of a Ca2+-binding protein, parvalbumin (PV), with peptides, cholecystokinin (CCK) and somatostatin (SS), all of which are known to be contained gamma-aminobutyric acidergic neurons in the cerebral cortex, was tested in the rat visual cortex by means of immunohistochemistry using the adjacent section technique. No PV immunoreactive (PV-I) neurons showed CCK-like immunoreactivity, and almost none (932 out of 934 PV-I neurons examined) showed SS-like immunoreactivity. These observations suggest that the GABAergic system of the cerebral cortex may consist of some distinct subsystems with different chemical and presumably physiological characteristics.
D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D007124:Immunoenzyme Techniques; D008297:Male; D010320:Parvalbumins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012844:Sincalide / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism; D009435:Synaptic Transmission; D014793:Visual Cortex / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D010320:Parvalbumins; D013004:Somatostatin; D005680:gamma-Aminobutyric Acid; D012844:Sincalide