Comparison of the effects of benzodiazepine and nonbenzodiazepine anxiolytics on mouse-killing behavior in rats.
The present study investigated the effects of nonbenzodiazepine anxiolytics on mouse-killing behavior in rats, compared with the effects of benzodiazepine anxiolytics. Mouse-killing behavior was induced by bilateral olfactory bulbectomy. The following drugs were administered intraperitoneally: chlordiazepoxide, diazepam, ethyl loflazepate, fludiazepam, zopiclone, suriclone, and CL 218,872. Among these drugs, suriclone (ED50 = 1.3 mg/kg) and fludiazepam (ED50 = 5.9 mg/kg) showed potent suppressive effects. Diazepam, ethyl loflazepate, and CL 218,872 showed only weak actions on mouse-killing behavior.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D008297:Male; D051379:Mice; D009830:Olfactory Bulb / Q000502:physiology; D051381:Rats
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines