The anticoagulant activity of some selected warfarin analogues.
The anticoagulant activities of 6-, 7-, 8-, 4'-hydroxy, 6-chloro- and 6-bromowarfarin were determined in rabbits after intraperitoneal administration of 16.2 mumol kg-1 over 96 h. Substitution on the 4-hydroxycoumarin moiety resulted in reduction of the anticoagulant activity. 6-Chlorowarfarin was more potent than 6-bromowarfarin suggesting that the molecular size of 4-hydroxycoumarin moiety may be crucial for biological activity.
D015110:4-Hydroxycoumarins / Q000097:blood / Q000494:pharmacology; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D008297:Male; D011517:Prothrombin Time; D011817:Rabbits; D014859:Warfarin / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology*
D015110:4-Hydroxycoumarins; D014859:Warfarin