[Characteristics of dimedrol, pipolfen and suprastin absorption from the small intestine of rats in systemic anaphylactic shock].
It was shown by the in situ method that absorption of dimedrol, pipolphen and suprastine from the small intestine of the rats immunized parenterally with ovalbumin against the background of intravenous administration of the resolving dose of ovalbumin significantly decreased in connection with the formation in the immunized rats of antiovalbumin antibodies. Administration of euphylline simultaneously with the resolving dose of ovalbumin to the immunized rats partially normalized absorbability of all three drugs.
D000628:Aminophylline / Q000494:pharmacology; D000707:Anaphylaxis / Q000209:etiology / Q000378:metabolism*; D000818:Animals; D004155:Diphenhydramine / Q000493:pharmacokinetics*; D004306:Dose-Response Relationship, Immunologic; D005029:Ethylenediamines / Q000493:pharmacokinetics*; D006634:Histamine H1 Antagonists / Q000493:pharmacokinetics*; D007114:Immunization / Q000379:methods; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011398:Promethazine / Q000493:pharmacokinetics*; D051381:Rats
D005029:Ethylenediamines; D006634:Histamine H1 Antagonists; D000628:Aminophylline; C004664:chloropyramine; D004155:Diphenhydramine; D010047:Ovalbumin; D011398:Promethazine
Osobennosti vsasyvaniia dimedrola, pipol'fena i suprastina iz tonkoĭ kishki krysy pri sistemnom anafilakticheskom shoke.