Chelating-agent suppression of cadmium-induced hepatotoxicity.
The administration of sodium N-methyl-N-dithiocarboxy-D-glucamine (NaG) at 500 mg/kg, i.p., or sodium calcium diethylenetriaminepentaacetic acid (DTPA) at 632.5 mg/kg, i.p., reduces the serum enzyme levels characteristic of hepatic damage following the intravenous administration of cadmium chloride (3.5 mg CdCl2.2.5H2O/kg). Some effect on serum enzyme levels was found even when the interval between administration of cadmium chloride and that of the antagonist was as great as 4 h. The enzymes examined included aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), alanine aminotransferase (SGPT), and alkaline phosphatase (AP). A histopathological examination of the livers of such animals also reveals the presence of a significant protective action.
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D002104:Cadmium / Q000493:pharmacokinetics / Q000633:toxicity*; D002614:Chelating Agents / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000628:therapy*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D014018:Tissue Distribution; D005723:gamma-Glutamyltransferase / Q000097:blood
D002614:Chelating Agents; D002104:Cadmium; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase