Spastic paraparesis and HTLV-I infection in Peru.
Three of 6 patients with spastic paraparesis in Lima, Peru, were found to have antibodies to human T-lymphotropic virus type I (HTLV-I). Blood and cerebrospinal fluid antibodies were confirmed by Western blot analysis. Multilobulated lymphocytes in blood and cerebrospinal fluid of the index case stained with monoclonal antibodies for T-helper cells and for T10, an activation marker. Blood mononuclear cells from patients with HTLV-I-associated myelopathy showed spontaneous proliferation in culture, evidence of interleukin-2 receptors, and decreased natural killer cell activity.
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis / Q000134:cerebrospinal fluid; D001773:Blood Cells / Q000473:pathology; D002455:Cell Division; D015480:Deltaretrovirus Antibodies; D006800:Deltaretrovirus Infections / Q000134:cerebrospinal fluid / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity / Q000134:cerebrospinal fluid / Q000209:etiology / Q000276:immunology / Q000473:pathology; D009187:Myelitis / Q000209:etiology; D010264:Paraplegia / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D010568:Peru; D013601:T-Lymphocytes / Q000145:classification
D000914:Antibodies, Viral; D015480:Deltaretrovirus Antibodies