Lateral olivocochlear neurons contain both enkephalin and dynorphin immunoreactivities: immunocytochemical co-localization studies.
Antibodies to methionine enkephalin and to dynorphin B were used in an immunocytochemical study examining co-containment of enkephalins and dynorphins in olivocochlear neurons in the guinea pig lateral superior olive. Two methods of sequential co-localization were employed: one using primary antibodies from different species, the second using elution of antibodies. Co-localization of enkephalin-like and dynorphin-like immunoreactivities was found in lateral olivocochlear neurons, suggesting co-containment of enkephalins and dynorphins in this projection pathway from the lateral superior olive to the organ of Corti.
D000818:Animals; D001306:Auditory Pathways / Q000378:metabolism; D003051:Cochlea / Q000294:innervation / Q000378:metabolism*; D004399:Dynorphins / Q000378:metabolism*; D004525:Efferent Pathways; D004744:Enkephalin, Methionine / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D009847:Olivary Nucleus / Q000378:metabolism*
D004744:Enkephalin, Methionine; D004399:Dynorphins