Fresh cell therapy followed by fatal coma.
A 60-year-old woman received a 3-day course of nine injections of "fresh" cells from fetal lamb ovary, placenta, brain (hypothalamus) and liver. There were no immediate complications, but a few days later she developed headache, fever and hemiparesis. She subsequently fell into a coma and died 3 weeks after her fresh cell therapy and 2 weeks after the onset of her clinical symptoms. Autopsy revealed perivenous leucoencephalopathy with a probably steroid-treatment-induced paucity of perivascular inflammation. Fresh cell therapy, clinical symptomatology and morphological findings suggest, though do not prove, that this patient's monophasic and probably immune-mediated disease is a rare fatal complication of fresh cell therapy.
D001812:Blood-Brain Barrier; D064987:Cell- and Tissue-Based Therapy / Q000009:adverse effects*; D002540:Cerebral Cortex / Q000473:pathology; D003128:Coma / Q000473:pathology*; D004673:Encephalomyelitis, Acute Disseminated / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000134:cerebrospinal fluid; D008264:Macrophages / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D009186:Myelin Sheath / Q000648:ultrastructure; D011149:Pons / Q000473:pathology
D007136:Immunoglobulins