title: A zebrafish homologue of the murine Hox-2.1 gene.
abstract: Homeobox-containing sequences were isolated from a genomic library of zebrafish (Brachydanio rerio). A lambda clone containing two homeobox cross-hybridizing regions was characterized. DNA sequencing of one of these regions (ZF-21) revealed that it contains a homeobox closely related to the Antennapedia class of Drosophila homeobox sequences. Moreover, the deduced amino acid sequence of the C-terminal end (81 residues including the homeobox) is identical to the corresponding part of the murine Hox-2.1 protein. Similar to Hox-2.1, a ZF-21 derived transcript of 2.3 kb is present in embryos at the somite forming stages.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D010582:Bacteriophage lambda / Q000235:genetics; D001483:Base Sequence; D003530:Cyprinidae / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004274:DNA, Recombinant; D004331:Drosophila melanogaster / Q000235:genetics; D005786:Gene Expression Regulation; D005801:Genes, Homeobox; D051379:Mice; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic; D015027:Zebrafish / Q000196:embryology / Q000235:genetics*
chemical_list: D004274:DNA, Recombinant; D004247:DNA