A comparison of nalbuphine with morphine for post-orchidopexy pain.
A double-blind investigation was conducted to compare nalbuphine with morphine for the control of pain after unilateral orchidopexy. Fifty boys under 11 years of age were allocated randomly to receive intramuscular nalbuphine 0.2 mgkg-1 or morphine 0.2 mgkg-1 immediately after induction of anaesthesia. Pain was assessed on a three-point scale, 1, 2 and 4 h after injection and on the morning following operation. Side-effects were also recorded. There were no significant differences between the two drugs in either the provision of analgesia, or the incidence of the principal side-effects of vomiting and sweating. There was a high incidence of vomiting in both groups. Nalbuphine is a satisfactory alternative to morphine for post-orchidopexy pain and may offer the advantages of greater safety and convenience.
D002648:Child; D002986:Clinical Trials as Topic; D003456:Cryptorchidism / Q000601:surgery*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D009019:Morphinans / Q000627:therapeutic use*; D009020:Morphine / Q000627:therapeutic use*; D009266:Nalbuphine / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000188:drug therapy*; D011897:Random Allocation
D009019:Morphinans; D009020:Morphine; D009266:Nalbuphine