Temelastine does not affect theophylline pharmacokinetics in normal subjects.
The pharmacokinetics of theophylline (i.v. aminophylline 250 mg) were studied in a balanced, double-blind crossover following the administration of oral temelastine (100 mg) or placebo, twice daily for 7 days, to 10 normal volunteers. Comparison of volumes of distribution, elimination rate constants, elimination half-lives and areas under the plasma concentration-time curve indicated that temelastine had no significant effect on theophylline pharmacokinetics.
D000328:Adult; D000628:Aminophylline / Q000097:blood; D004347:Drug Interactions; D005260:Female; D006634:Histamine H1 Antagonists / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011744:Pyrimidinones / Q000097:blood / Q000494:pharmacology*; D013806:Theophylline / Q000493:pharmacokinetics*
D006634:Histamine H1 Antagonists; D011744:Pyrimidinones; D000628:Aminophylline; C049054:temelastine; D013806:Theophylline