title: Three-point linkage analysis employing C3 and 19cen markers assigns the myotonic dystrophy gene to 19q.
abstract: In seven large families with myotonic dystrophy (DM) comprising 102 individuals, linkage studies were performed employing restriction fragment length polymorphisms in the complement component 3 gene and the 19cen C banding heteromorphism as genetic markers. Three-point linkage analysis excludes DM from the 19cen-C3 segment and strongly supports its assignment to the proximal long arm of chromosome 19.
mesh_terms: D002888:Chromosomes, Human, Pair 19; D003176:Complement C3 / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D009223:Myotonic Dystrophy / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D003176:Complement C3; D005819:Genetic Markers