title: Sexing the human pre-embryo by DNA-DNA in-situ hybridisation.
abstract: Human male pre-embryos were identified by means of DNA-DNA in-situ hybridisation with a commercially available DNA probe for Y-chromosome DNA. This method could lead to prenatal diagnosis of genetic disorders based on small numbers of cells that are not necessarily in division, such as cells obtained from a pre-embryo during the course of in-vitro fertilisation therapy.
mesh_terms: D001345:Autoradiography; D004247:DNA / Q000032:analysis*; D047108:Embryonic Development; D005260:Female; D005307:Fertilization in Vitro; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D008297:Male; D009693:Nucleic Acid Hybridization; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012743:Sex Preselection / Q000379:methods*; D014998:Y Chromosome / Q000032:analysis*
chemical_list: D004247:DNA