[Dynamics of various indicators of cellular immunity in patients with diffuse toxic goiter after drug therapy].
The purpose of the investigation was to study some indices of the immune system of patients with diffuse toxic goiter (DTG) before multimodality thyrostatic therapy and after achieving clinical remission. A total of 30 DTG patients with an average severity of disease were examined. The immune status was evaluated according to the content of T-lymphocytes, T-suppressors, Fc gamma-lymphocytes and antigen-binding lymphocytes (ABL) responsive to thyroglobulin. Conservative therapy included mercazolyl, beta-adrenergic blockers, sedative and cardiac drugs. A drop of T1T gamma and Fc gamma-lymphocytes was revealed in the period of the manifestation of the clinical signs of disease. The indices of ABL responsive to thyroglobulin significantly exceeded the relative and absolute indices of the control group. Multimodality drug therapy resulted in the deepening of T-lymphocyte deficiency, a significant rise of T gamma 1 and T gamma 2 as compared to the initial levels. A tendency to a decrease in the level of Fc gamma-lumphocytes was noted after the therapy. The relative and absolute values of the ABL indices significantly decreased, however a significant increase in these indices compared to the control ones maintained.
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D006111:Graves Disease / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D007958:Leukocyte Count; D008713:Methimazole / Q000008:administration & dosage; D008875:Middle Aged; D011961:Receptors, Fc / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000319:Adrenergic beta-Antagonists; D006993:Hypnotics and Sedatives; D007141:Immunoglobulin Fc Fragments; D011961:Receptors, Fc; D008713:Methimazole
Dinamika nekotorykh pokazateleĭ kletochnogo immuniteta u bol'nykh diffuznym toksicheskim zobom pod vliianiem medikamentoznoĭ terapii.