Molecular structure of human lymphocyte receptor for immunoglobulin E.
We have isolated and sequenced a cDNA clone encoding the human lymphocyte receptor for IgE (Fc epsilon R). The deduced protein sequence reveals that Fc epsilon R consists of 321 amino acids, without any signal sequence, and is oriented with its N-terminus on the cytoplasmic side and its C-terminus on the outside of the cell. This molecule shows striking sequence homology with chicken asialoglycoprotein receptor (hepatic lectin), suggesting a possible role for Fc epsilon R in endocytosis. Fc epsilon R mRNA is expressed in B cells, B cell lines, and macrophage cell lines. It is not expressed in T cells or T cell lines, with the exception of an HTLV-transformed T cell line. mRNAs expressed in a macrophage line and in the latter T cell line differ in size from mRNA expressed in B cells. Human BSF-1 (or IL-4) induces the expression of Fc epsilon R mRNA in B cells, but not in T cells.
D000595:Amino Acid Sequence; D000818:Animals; D037263:Asialoglycoprotein Receptor; D001402:B-Lymphocytes / Q000276:immunology*; D001483:Base Sequence; D002645:Chickens / Q000235:genetics; D004247:DNA / Q000235:genetics; D006801:Humans; D007739:L Cells / Q000032:analysis; D051379:Mice; D011061:Poly A / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D011961:Receptors, Fc / Q000235:genetics*; D017455:Receptors, IgE; D011971:Receptors, Immunologic / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D037263:Asialoglycoprotein Receptor; D012333:RNA, Messenger; D011961:Receptors, Fc; D017455:Receptors, IgE; D011971:Receptors, Immunologic; D011061:Poly A; D004247:DNA