Effects of chronic ethanol administration on hepatic cholesterol and bile acid synthesis in relation to serum high density lipoprotein cholesterol in rats.
In ethanol-fed rats for 4 or 7 weeks, hepatic HMG-CoA reductase activity was significantly increased, and correlated positively with hepatic microsomal gamma-GTP activity. By contrast, hepatic cholesterol 7 alpha-hydroxylase activity was decreased in these rats. The content of hepatic cholesterol and levels of serum cholesterol and HDL-cholesterol were significantly increased in these rats, correlating significantly with hepatic HMG-CoA reductase activity, but not with hepatic cholesterol 7 alpha-hydroxylase activity. These results suggest that the increase in serum levels of cholesterol and HDL-cholesterol by ethanol feeding is mainly regulated by the enhanced cholesterol synthesis in the liver.
D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis*; D002784:Cholesterol / Q000096:biosynthesis*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D001647:Bile Acids and Salts; D008076:Cholesterol, HDL; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D002790:Cholesterol 7-alpha-Hydroxylase; D005723:gamma-Glutamyltransferase