Successful treatment of primary hyperoxaluria type I by combined hepatic and renal transplantation.
A patient with primary hyperoxaluria type 1 (hepatic peroxisomal alanine:glyoxylate aminotransferase [EC 2.6.1.44] deficiency) was successfully treated by combined hepatic and renal transplantation. The metabolic lesion was corrected by replacement of the deficient hepatic enzyme activity.
D000328:Adult; D000410:Alanine Transaminase / Q000172:deficiency*; D005069:Evaluation Studies as Topic; D006801:Humans; D006959:Hyperoxaluria / Q000628:therapy*; D016030:Kidney Transplantation; D008099:Liver / Q000201:enzymology; D016031:Liver Transplantation; D008297:Male; D010070:Oxalates / Q000378:metabolism; D011183:Postoperative Complications; D000637:Transaminases
D010070:Oxalates; D000637:Transaminases; D000410:Alanine Transaminase; C019635:Alanine-glyoxylate transaminase