New approaches to the diagnosis and therapy of the luteinized unruptured follicle syndrome.
Ultrasound has been employed in diagnosing the luteinized unruptured follicle syndrome (LUF). Eighty-nine of 333 infertility patients were found to have LUF. The patients were divided into three groups. Group 1 was on no fertility medication. Twenty-five of 39 of this group released with HCG alone. Ten of the nonreleasers to HCG did release with HMG mixed with HCG. Group 2 patients had been treated with clomiphene and found to have LUF. Thirteen of 16 patients released with HCG and one of the failures released with HMG-HCG. Group 3 patients had been treated with HMG and had failed to release the ova despite HCG. Thirty-one of 33 did release with HMG-HCG. Twenty-six of 89 patients achieved a pregnancy within six months of therapy and 20 of 36 patients with all fertility factors corrected achieved a pregnancy.
D000858:Anovulation / Q000209:etiology; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D003338:Corpus Luteum / Q000502:physiology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D008596:Menotropins / Q000627:therapeutic use; D010049:Ovarian Diseases / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D006080:Ovarian Follicle / Q000502:physiology; D011247:Pregnancy; D013577:Syndrome; D014463:Ultrasonography
D006063:Chorionic Gonadotropin; D008596:Menotropins