[Effect of adrenomimetic drugs on the blood vessels of the genital organs of swine during the estrous cycle].
The flow in uterine artery (ua) and ovarian artery (oa) was measured in isolated reproductive organs of sows perfounded with own blood of the animal or with Krebs-Henseleit fluid at the constant pressure of 100 mm Hg applying the haemotachometric method. Controlling parallel to the flow, the condition of tension in smooth muscle of the organ, the sensitivity of vessels of ua and oa areas to: norepinephrine (NA), phenylephrine (F), epinephrine (A) and isoprenaline (I) on the 1-2, 13-14 and 16-18 days of oestrous cycle was investigated. It was found that the blood flow in the vessels under investigation diminishes after intraarterial application of alpha-adrenomimetic NA and F and after ambi-receptor acting A, while it increases after beta-adrenomimetic I. It was also shown, that the vessels of the area oa are many times less sensitive to the applied agents than the vessels of the ua area. During the oestrous cycle significant changes in sensitivity of both areas to adrenomimetic agents take place. The highest sensitivity to NA, A and F simultaneous with the lowest sensitivity to I were noted in the ua area on 13-14 days. On the 16-18 and 1-2 days of the cycle the diminished sensitivity to NA, A and F and increased to I comparing with the 13-14 day was found. Also, the vessels of the oa area show the lowest sensitivity to NA, A and F and the highest to I on the 1-2 day of the cycle. It is the highest to NA and F on the 13-14 day and is accompanied by the lowest sensitivity to I. The sensitivity on 13-14 day is similar to that on 16-18 day. The sensitivity of oa area to A increases from the lowest on 1-2 days to the highest on 16-18 day of the cycle.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D001158:Arteries / Q000502:physiology; D004971:Estrus / Q000502:physiology*; D005260:Female; D010053:Ovary / Q000098:blood supply*; D012039:Regional Blood Flow / Q000187:drug effects; D013552:Swine / Q000502:physiology*; D014599:Uterus / Q000098:blood supply*
D000316:Adrenergic alpha-Agonists
Wpływ środków adrenomimetycznych na naczynia narzadu rodnego świń w przebiegu cyklu rujowego.