Evidence against VIP-involvement in neurogenic relaxations of the mouse anococcygeus muscle.
Vasoactive intestinal polypeptide (VIP) antiserum, alpha-chymotrypsin, and repeated exposure to VIP markedly reduced relaxations of the mouse anococcygeus muscle to VIP but not to field stimulation. This evidence suggests that VIP does not mediate non-adrenergic, non-cholinergic relaxations in the mouse anococcygeus.
D000818:Animals; D002217:Carbachol / Q000037:antagonists & inhibitors; D002918:Chymotrypsin / Q000494:pharmacology; D004558:Electric Stimulation; D007106:Immune Sera / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D014660:Vasoactive Intestinal Peptide / Q000276:immunology / Q000502:physiology*
D007106:Immune Sera; D014660:Vasoactive Intestinal Peptide; D002217:Carbachol; D002918:Chymotrypsin