Somatostatin and Alzheimer's disease: a hypothesis.
Recent data suggest a disturbance of some brain somatostatin neurons in Alzheimer's disease. Moreover, some endocrine activities known to be regulated by somatostatin, such as growth hormone, thyroid-stimulating-hormone, somatomedins, as well as insulin and glucose metabolism, also seem to be affected in some patients. It is speculated that these changes are due to a global CNS and endocrine somatostatin defect in Alzheimer's disease and that the described endocrine imbalance may indirectly be responsible for at least part of the CNS pathology.
D000544:Alzheimer Disease / Q000209:etiology*; D001921:Brain / Q000503:physiopathology*; D006801:Humans; D013004:Somatostatin / Q000502:physiology*
D013004:Somatostatin