[Metipranolol 0.1% and pilocarpine 2% as a fixed combination compared to each substance alone in the treatment of glaucoma. A controlled, randomized clinical study comparing the intraindividual effects and tolerance].
A fixed combination of pilocarpine 2% and metipranolol 0.1% was found to have a better pressure-lowering effect than pilocarpine 2% alone or metipranolol 0.1% alone, as well as being tolerated well, both subjectively and objectively. In many cases only the fixed combination was successful in lowering intraocular pressure to tolerable values.
D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D014290:Metipranolol / Q000009:adverse effects / Q000627:therapeutic use*; D010862:Pilocarpine / Q000009:adverse effects / Q000627:therapeutic use*; D011412:Propanolamines / Q000627:therapeutic use*; D011897:Random Allocation
D011412:Propanolamines; D010862:Pilocarpine; D014290:Metipranolol
Metipranolol 0,1% und Pilokarpin 2% als fixe Kombination im Vergleich zu den Monosubstanzen in der Behandlung des Glaukoms. Eine kontrollierte, randomisierte klinische Studie zum intraindividuellen Wirkungs- und Verträglichkeitsvergleich.