title: Acute meningo-encephalitis on dose reduction of zidovudine.
abstract: In a study of treatment by zidovudine in 106 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex, an acute meningo-encephalitic illness developed in 4 of 21 patients within 17 days after the dose of zidovudine had had to be reduced because of myelotoxicity. 3 of the 4 patients had previous clinical evidence of HIV encephalopathy. AIDS-related opportunist infection of the central nervous system was excluded. This acute meningo-encephalitic illness probably results from an increase in HIV replication following dose reduction.
mesh_terms: D000386:AIDS-Related Complex / Q000150:complications / Q000188:drug therapy; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy; D000208:Acute Disease; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006678:HIV / Q000502:physiology; D006716:Homosexuality; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000209:etiology*; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology; D013921:Thrombocytopenia / Q000209:etiology; D013936:Thymidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine
chemical_list: D000998:Antiviral Agents; D015215:Zidovudine; D013936:Thymidine