Resistance of a measles virus mutant to fusion inhibitory oligopeptides is not associated with mutations in the fusion peptide.
The nucleotide sequence and predicted amino acid sequence has been obtained for the fusion (F) protein gene of the R93 strain of measles virus and compared to that of the parental strain, Edmonston B. The R93 strain is a mutant measles virus which is able to grow and induce cell fusion in the presence of the fusion inhibiting oligopeptide, Z-D-Phe-L-Phe-L-(NO2)Arg (SV4814). Primer extension sequencing on isolated R93 mRNA demonstrated the presence of three nucleotide changes leading to three amino acid changes, none of which are in the hydrophobic NH2-terminal region of the F1 polypeptide.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002459:Cell Fusion / Q000187:drug effects; D004352:Drug Resistance, Microbial; D008459:Measles virus / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D009842:Oligopeptides / Q000494:pharmacology; D011061:Poly A / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D014709:Vero Cells; D014760:Viral Fusion Proteins / Q000235:genetics* / Q000502:physiology
D009842:Oligopeptides; D012333:RNA, Messenger; D012367:RNA, Viral; D014760:Viral Fusion Proteins; D011061:Poly A