Red cell antigens P (globoside) and Luke: identification by monoclonal antibodies defining the murine stage-specific embryonic antigens -3 and -4 (SSEA-3 and SSEA-4).
Two globoseries antigens (antigens borne on carbohydrate chains containing globoside), SSEA-3 and SSEA-4, were found on the red cells of the majority of people, but were absent from cells of rare p and Pk individuals which lack globoside. In addition, SSEA-4 was absent from red cells of Luke(-) individuals which nevertheless express the P antigen (globoside) and SSEA-3. The name LKE is proposed for the red cell antigen detected by the Luke serum and by MC813-70, the monoclonal antibody defining SSEA-4. Among the LKE+ individuals, a few showed relatively weak expression of the antigen and were grouped separately as a LKE weak (LKEw) phenotype. Using MC813-70, the frequencies of the 3 phenotypes LKE+, LKEw and LKE- in an English donor population are 0.914, 0.072 and 0.014, respectively.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000941:Antigens / Q000276:immunology; D001789:Blood Group Antigens / Q000276:immunology*; D005787:Gene Frequency; D005915:Globosides / Q000276:immunology; D006017:Glycolipids / Q000276:immunology*; D006801:Humans; D016256:Lewis X Antigen; D051379:Mice; D010127:P Blood-Group System / Q000235:genetics / Q000276:immunology*; D010641:Phenotype
D000911:Antibodies, Monoclonal; D000941:Antigens; D001789:Blood Group Antigens; D005915:Globosides; D006017:Glycolipids; D016256:Lewis X Antigen; D010127:P Blood-Group System