Regional distribution and density of Thy 1.1 in rat brain and its relation to subpopulations of neurons.
We have used a radioimmunohistochemical technique employing OX-7, a monoclonal antibody to rat Thy 1.1, to determine the regional distribution and density of Thy 1 in rat brain. Thy 1.1 was found to be unevenly distributed in rat brain with distinct regional differences related to the density of neuronal perikarya. This is consistent with the previously reported findings that Thy 1.1 is found primarily on neurons. However, the relative absence of Thy 1 in some cell body-dense areas of the brain suggests that Thy 1 is expressed differentially on specific subsets of neurons which are abundant and widespread throughout the brain.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis*; D001921:Brain / Q000166:cytology / Q000276:immunology*; D008297:Male; D009474:Neurons / Q000145:classification* / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D018800:Thy-1 Antigens