title: Comparative amnestic effects of benzodiazepine hypnotic agents.
abstract: The effects of triazolam 0.5 mg and temazepam 30 mg on immediate and delayed recall in normal and insomniac subjects were evaluated in three separate, randomized, placebo-controlled, parallel group studies. Neither drug caused significant impairment of immediate recall. In the tests of delayed recall, triazolam caused a consistent anterograde amnestic effect. No significant impairment of delayed recall was observed in the temazepam study. Anterograde amnesia is thought to be a dose-related effect of benzodiazepines. Compounds with high benzodiazepine receptor affinity such as triazolam are thought to cause this type of amnesia more often than the lower-affinity compounds such as temazepam.
mesh_terms: D000328:Adult; D000647:Amnesia / Q000139:chemically induced*; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008570:Memory, Short-Term / Q000187:drug effects; D011939:Mental Recall / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy; D013693:Temazepam / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D014229:Triazolam / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D014151:Anti-Anxiety Agents; D014229:Triazolam; D013693:Temazepam