title: Plasma intestinal alkaline phosphatase and intermediate molecular mass gamma glutamyltransferase activities in the differential diagnosis of jaundice.
abstract: An assessment was made of the value of: (i) the demonstration of intestinal alkaline phosphatase in plasma for the differentiation of intrahepatic from post-hepatic jaundice in 122 jaundiced patients; and (ii) the demonstration of an intermediate molecular mass gamma glutamyltransferase in plasma for the identification of post-hepatic cholestasis in 74 jaundiced patients. The first test had a diagnostic sensitivity of only 32% with a specificity of 86%; the second test had a sensitivity of 50% and specificity of 75%. It is concluded that neither procedure is worth while.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood*; D001651:Cholestasis, Extrahepatic / Q000175:diagnosis* / Q000201:enzymology; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis* / Q000201:enzymology; D003937:Diagnosis, Differential; D006801:Humans; D007422:Intestines / Q000201:enzymology; D007527:Isoenzymes / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D007527:Isoenzymes; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase