A new non-hormonal antifertility drug DL-204: II. Effect on testicular hyaluronidase and gamma-glutamyl transpeptidase in male rats.
Effects of DL-204, 2-(3-ethoxyphenyl)-5,6-dihydro (5,1-a)-isoquinoline, a non-hormonal antifertility drug on testicular hyaluronidase and gamma-glutamyl transpeptidase levels, biochemical markers for testicular function, were evaluated in male rats. Treatment of 21-day-old rats with DL-204 for 7 or 15 days produced cryptorchid condition. Testicular hyaluronidase and gamma-glutamyl transpeptidase levels reveal that DL-204 acts on the testes, possibly in two ways; one, by reducing the gonadotropin levels thereby reducing the levels of androgens as reflected by reduced accessory reproductive organ weights and, secondly, by a direct action on the testes. Thus, we conclude that DL-204 is acting as an antispermatogenic agent, possibly acting in more than one way on the testes.
D000367:Age Factors; D000818:Animals; D000988:Antispermatogenic Agents / Q000494:pharmacology*; D006821:Hyaluronoglucosaminidase / Q000378:metabolism*; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000187:drug effects / Q000201:enzymology*; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D000988:Antispermatogenic Agents; D007546:Isoquinolines; C014924:L 11204; D005723:gamma-Glutamyltransferase; D006821:Hyaluronoglucosaminidase