title: Diffusion of metronidazole through the dentinal tubules of extracted teeth.
abstract: Passing of metronidazole from the root canal of extracted gangrenous teeth through the dentinal tubules was proved by agar diffusion and minimum inhibitory concentration assay. The findings explain the excellent clinical experience with metronidazole in root treatment.
mesh_terms: D001441:Bacteroides fragilis / Q000187:drug effects; D003016:Clostridium perfringens / Q000187:drug effects; D003790:Dental Pulp Necrosis / Q000188:drug therapy* / Q000378:metabolism; D003804:Dentin / Q000378:metabolism*; D004058:Diffusion; D006801:Humans; D066298:In Vitro Techniques; D008795:Metronidazole / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D008795:Metronidazole