Effect of food on absorption of chlordemethyldiazepam.
The kinetics of a single 1-mg oral dose of chlordemethyldiazepam (CDDZ, En) was determined on two occasions in 8 healthy volunteers. CDDZ was given in the fasting state on one occasion and following a standard meal on another. Compared with the fasting state, administration of CDDZ with food prolonged the time to reach peak concentration (1.5 vs. 6.8 h after dosage, p less than 0.01) and the absorption half-life (28 vs. 231 min, p less than 0.01). Total area under the curve was not influenced, nor was CDDZ elimination half-life (84.2 vs. 88.7 h). Thus administration of CDDZ with food slows the rate of its absorption but does not alter the completeness of absorption.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics*; D001569:Benzodiazepines; D002849:Chromatography, Gas; D003975:Diazepam / Q000031:analogs & derivatives*; D005502:Food; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D003708:Nordazepam / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D003708:Nordazepam; C013434:chlordesmethyldiazepam; D003975:Diazepam