Beta-adrenoceptor blockade, alpha-stimulation and changes in plasma potassium concentration after suxamethonium administration in dogs.
A study involving 20 mongrel dogs tested the hypotheses that beta-adrenoceptor blockade or alpha-adrenoceptor stimulation may potentiate and prolong the increase in plasma potassium concentration after suxamethonium administration, and that the beta effect is beta 2-receptor mediated. Propranolol 0.5 mg kg-1 altered the time to peak increase in plasma concentration of potassium after suxamethonium, but did not increase peak concentrations. In controls, the maximum change (0.83 mmol litre-1) occurred at 3 min, while in propranolol-treated dogs the peak change (0.96 mmol litre-1 occurred at 30 min. Similar results were obtained when metoprolol 0.25 mg kg-1 and ICI 118551 0.1 mg kg-1 were used, respectively, as selective beta 1- and beta 2-adrenoceptor blockers. The increases in potassium concentration following suxamethonium in the metoprolol group (0.98 mmol litre-1) and the ICI 118551 group (0.82 mmol litre-1) reached maximum concentrations at 30 min compared with the controls (0.79 mmol litre-1) which achieved a maximum at 3 min. Phenylephrine was infused at 8 micrograms kg-1 min-1 to produce alpha stimulation. The infusion alone altered plasma concentrations of potassium, but the haemodynamic changes were such that conclusions as to the effect of alpha-stimulation on release of potassium after suxamethonium could not be reached.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D008790:Metoprolol / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011188:Potassium / Q000097:blood*; D011412:Propanolamines / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013390:Succinylcholine / Q000494:pharmacology*; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D010656:Phenylephrine; C026777:ICI 118551; D011433:Propranolol; D008790:Metoprolol; D013390:Succinylcholine; D011188:Potassium