title: [Therapeutic indications of S-adenosyl methionine in neuropsychiatry].
abstract: Studies conducted by Italian and Anglo-saxon authors underline the thymoanaleptic properties of a transmethylant biological substance, the S-adenosyl methionine (SAMe). The authors discuss a review of literature concerning the use of SAMe in neuro-psychiatry, particularly in the treatment of affective disorders. The many physiopathological implications are subtended by the biological inter-relations of SAMe with other biological substances. Some hypotheses are proposed on the role played by phospholipid methylation, the folate metabolism and the purinergic transmission in mental diseases.
mesh_terms: D001923:Brain Chemistry; D005492:Folic Acid / Q000378:metabolism; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D001523:Mental Disorders / Q000188:drug therapy*; D008745:Methylation; D018377:Neurotransmitter Agents / Q000378:metabolism; D012436:S-Adenosylmethionine / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D008563:Membrane Lipids; D018377:Neurotransmitter Agents; D012436:S-Adenosylmethionine; D005492:Folic Acid
vernacular_title: Indications thérapeutiques de la S-adénosyl méthionine (SAMe) en neuro-psychiatrie.