Studies on comparative drug metabolism by hepatic cytochrome P-450-containing microsomal enzymes in quail, ducks, geese, chickens, turkeys and rats.
1. These studies were carried out to compare certain hepatic microsomal drug-metabolizing enzymes of quail, ducks, geese, chickens, turkeys and rats. 2. Comparison of relative liver weights of the species indicated that the rats had the largest weight followed by turkeys, ducks, geese, chickens and quail. 3. Rats ranked highest in hepatic cytochrome P-450 content followed in decreasing order by turkeys, geese, chickens, ducks and quail. 4. Microsomal benzphetamine N-demethylase activity was significantly higher in geese and turkeys than that for the rest of the species. 5. Geese, chickens and turkeys showed similar aniline hydroxylase activity, while it was markedly lower in quail and ducks with rats being intermediate.
D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D002645:Chickens; D003370:Coturnix; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004372:Ducks; D005260:Female; D005777:Geese; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009929:Organ Size; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D013045:Species Specificity; D014422:Turkeys
D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D000815:Aniline Hydroxylase; C019781:benzphetamine N-demethylase; D010089:Oxidoreductases, N-Demethylating