Effect of acepromazine, diazepam, fentanyl-droperidol, and oxymorphone on gastroesophageal sphincter pressure in healthy dogs.
Treatment of healthy dogs with 4 commonly used psychotropic or analgesic agents significantly decreased resting gastroesophageal sphincter pressure (GESP). Acepromazine decreased GESP by 35% (P = 0.02); oxymorphone decreased GESP by 38% (P less than 0.005); diazepam decreased GESP by 42% (P = 0.005); and fentanyl-droperidol decreased GESP by 40% (P = 0.03). Therefore, esophageal manometric evaluation of gastroesophageal sphincter function should not be preceded by administration of these drugs.
D000075:Acepromazine / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D004285:Dogs / Q000502:physiology*; D004329:Droperidol / Q000494:pharmacology; D004338:Drug Combinations; D004943:Esophagogastric Junction / Q000187:drug effects* / Q000502:physiology; D005283:Fentanyl / Q000494:pharmacology; D010111:Oxymorphone / Q000494:pharmacology; D011312:Pressure; D014149:Tranquilizing Agents / Q000494:pharmacology*
D000701:Analgesics, Opioid; D004338:Drug Combinations; D014149:Tranquilizing Agents; D000075:Acepromazine; D010111:Oxymorphone; D004329:Droperidol; D003975:Diazepam; D005283:Fentanyl