[Effect of M and N-cholinoblockers on the excitability of the dorsal hippocampus in acute alcoholic intoxication].
It has been established in chronic experiments on rabbits that acute alcohol intoxication increased the after-discharge thresholds in response to electrical stimulation of dorsal hippocampus. It has been shown that neurotropic agents selectively blocking M- or N-cholinoceptors exerted various effects. M-cholino-blocker methamizol (1 mg/kg, i. p.) decreased the excitability of dorsal hippocampus, potentiated EEG and behavioural effects of alcohol intoxication. N-cholinoblocker etherophen (IEM-506, 20 mg/kg, i. p.), on the contrary, increased the excitability of dorsal hippocampus and reduced behavioural effects of alcohol administration.
D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D001535:Benactyzine / Q000031:analogs & derivatives / Q000494:pharmacology; D004158:Diphenylacetic Acids / Q000031:analogs & derivatives / Q000494:pharmacology; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects* / Q000503:physiopathology; D010276:Parasympatholytics / Q000494:pharmacology*; D011817:Rabbits; D013565:Sympatholytics / Q000494:pharmacology*
D004158:Diphenylacetic Acids; D010276:Parasympatholytics; D013565:Sympatholytics; C002675:ethyldiphacil; C008380:metamizil; D001535:Benactyzine
Vliianie M- i N-kholinoblokatorov na vozbudimost' dorsal'nogo gippokampa v usloviiakh ostroĭ alkogol'noĭ intoksikatsii.