Parasitological and serological surveys for malaria among the inhabitants of an aborigine village and an adjacent Malay village.
Malaria surveys in an Orang Asli (aborigine) and an adjacent Malay village showed significantly higher parasite rates in the age-group 0-9 years in the former. Parasite rates declined progressively from a maximum at 0-4 years in the Orang Asli to zero at 30-39 years while in the Malays it rose progressively with age. Indirect fluorescent antibody test (IFAT) titres against schizont antigens of Plasmodium falciparum and P. cynomolgi were higher in the Orang Asli in all age-groups with a statistically significant inverse relationship between IFAT titres and parasite rates. IFAT titres in the Malay population also increased with age but were very much lower. Antibody levels detected by the enzyme-linked immunosorbent assay (ELISA) using soluble schizont antigens were also much higher in the Orang Asli and values with P. cynomolgi were higher than those with P. falciparum antigens. These differences are attributed to the higher malaria transmission in the younger age-groups of the Orang Asli and presumably greater immunological experience to a wider diversity of antigens than the Malays, thus explaining the presence of "protective" antibodies in the former but not the latter group.
D000367:Age Factors; D000906:Antibodies / Q000032:analysis; D000953:Antigens, Protozoan / Q000276:immunology; D006801:Humans; D008288:Malaria / Q000453:epidemiology* / Q000276:immunology / Q000469:parasitology; D010963:Plasmodium falciparum
D000906:Antibodies; D000953:Antigens, Protozoan