title: Actions of deltamethrin and tralomethrin on cholinergic synaptic transmission in the central nervous system of the cockroach (Periplaneta americana).
abstract: Deltamethrin (RU 22974) and tralomethrin isomers (RU 24784 and RU 24785) block transmission at the cercal-afferent giant-interneuron synapses of the cockroach, when bath-applied to the desheathed ganglion at micromolar concentrations. The time-course of the events leading to the blockage suggests two possible target sites: one located presynaptically and the other situated on postsynaptic membranes.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002799:Cholinergic Fibers / Q000187:drug effects*; D003058:Cockroaches / Q000502:physiology*; D066298:In Vitro Techniques; D009570:Nitriles; D010526:Periplaneta / Q000502:physiology*; D011722:Pyrethrins / Q000494:pharmacology*; D013570:Synaptic Membranes / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors
chemical_list: D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin; D000109:Acetylcholine; C035705:tralomethrin