[Expression of class II genes in regulatory T-lymphocyte populations in mice and the possible mechanism of genetic restriction of region I of the H-2 complex].
Some contradictions exist in molecular and classical mapping of genes controlling I-J and I-AT (Iat) determinants of the T suppressor and T helper murine lymphocytes. There is strong evidence in favour of the hypothesis that lat molecules function as components of the T receptor for self Ia proteins in a I-restricted manner. These data are discussed from the point of view that beta-genes of the I region of the H-2 complex may control Iat determinants of regulatory T lymphocytes' receptors. A hypothesis is proposed that the I-region-determined restriction is based on interactions between alpha-chains of Ia molecules on A cells and beta-chains of receptors on T lymphocytes.
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000648:ultrastructure; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005786:Gene Expression Regulation; D005802:Genes, MHC Class II; D005815:Genetic Code; D006183:H-2 Antigens / Q000235:genetics* / Q000276:immunology; D051379:Mice; D014176:Protein Biosynthesis; D013601:T-Lymphocytes / Q000276:immunology / Q000648:ultrastructure*
D006183:H-2 Antigens; D004247:DNA
Ekspressiia genov klassa II v reguliatornykh populiatsiiakh T-limfotsitov myshi i vozmozhnyĭ mekhanizm geneticheskoĭ restriktsii po oblasti I kompleksa H-2.