[Effect of alpha- and beta-adrenoreceptor blockaders on thyroid function in rats of various ages].
The effect of alpha-adrenoblocker dibenamine and beta-adrenoblocker propranolol on the blood level of thyroid hormones (TH) and TH production by isolated thyroids (T) was investigated in adult and old male rats. Isolated T were incubated for 4 h in medium 199 with or without TSH (100 mU/ml). TH blood concentration and specific TH production by isolated T was decreased with age. TSH stimulated thyroid hormone production in isolated T only in adult rats. Alpha- or beta-adrenoblockers administration resulted in a decrease in the TH blood concentration, basal and TSH-stimulated thyroid hormone production in adult rats. The results obtained suggested that aging was accompanied by decreased adrenergic control of thyroid function.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D003864:Depression, Chemical; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013963:Thyroid Hormones / Q000096:biosynthesis; D013972:Thyrotropin / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D013963:Thyroid Hormones; D013972:Thyrotropin
Vliianie blokatorov al'fa- i beta-adrenoretseptorov na funktsiiu shchitovidnoĭ zhelezy u zhivotnykh raznogo vozrasta.