Efficacy of multiple-dose halofantrine in treatment of chloroquine-resistant falciparum malaria in children in Kenya.
Halofantrine hydrochloride given to 46 Kenyan children with falciparum malaria at 10 mg/kg for two doses, and to 60 other children at 8 mg/kg for three doses, resulted in rapid parasite clearance, mean parasite clearance times being 45.4 h and 54.8 h, respectively. In-vitro chemosensitivity tests showed that most infections were due to chloroquine-resistant parasites, and that parasite maturation was inhibited by considerably lower concentrations of halofantrine than of chloroquine.
D000284:Administration, Oral; D000293:Adolescent; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D004351:Drug Resistance; D005260:Female; D005500:Follow-Up Studies; D006207:Half-Life; D006801:Humans; D007223:Infant; D007630:Kenya; D008288:Malaria / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology / Q000652:urine; D008297:Male; D010616:Phenanthrenes / Q000008:administration & dosage* / Q000627:therapeutic use; D010963:Plasmodium falciparum; D013997:Time Factors
D000962:Antimalarials; D010616:Phenanthrenes; D002738:Chloroquine; C023768:halofantrine