Mean residence time for drugs subject to reversible metabolism.
Conventional methods based on moment analysis lead to biased estimates of the mean residence time for drugs subject to reversible metabolism. A stochastic approach is described which enables unbiased estimation of the mean residence time.
D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D004364:Pharmaceutical Preparations