Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor.
Gastric inhibitory polypeptide (GIP) is a 42-amino acid hormone that stimulates insulin secretion in the presence of glucose. Complementary DNA clones encoding human GIP were isolated from a library prepared with RNA from duodenum. The predicted amino acid sequence indicates that GIP is derived by proteolytic processing of a 153-residue precursor, preproGIP. The GIP moiety is flanked by polypeptide segments of 51 and 60 amino acids at its NH2 and COOH termini, respectively. The former includes a signal peptide of about 21 residues and an NH2-terminal propeptide of 30 amino acids. GIP is released from the precursor by processing at single arginine residues. There is a region of nine amino acids in the COOH-terminal propeptide of the GIP precursor that has partial homology with a portion of chromogranin A as well as pancreastatin.
D000595:Amino Acid Sequence; D001483:Base Sequence; D053379:Chromogranin A; D002864:Chromogranins / Q000235:genetics; D004247:DNA / Q000235:genetics*; D004386:Duodenum / Q000032:analysis; D005749:Gastric Inhibitory Polypeptide / Q000235:genetics*; D008969:Molecular Sequence Data; D010187:Pancreatic Hormones / Q000235:genetics; D011061:Poly A / Q000235:genetics; D011498:Protein Precursors / Q000235:genetics*; D021382:Protein Sorting Signals / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
D053379:Chromogranin A; D002864:Chromogranins; D010187:Pancreatic Hormones; D011498:Protein Precursors; D021382:Protein Sorting Signals; D012333:RNA, Messenger; C050836:pancreastatin; D011061:Poly A; D005749:Gastric Inhibitory Polypeptide; D004247:DNA