title: Histamine-induced hyperphosphatemia and hypocalcemia in the laying hen.
abstract: The effects of histamine on plasma inorganic phosphorus (Pi) and total calcium values were studied in laying hens during egg formation and in non-laying hens. Histamine induced hyperphosphatemia and slight hypocalcemia during eggshell calcification, whereas the most pronounced hypocalcemia was observed during the early stages of egg formation. The histamine-induced hyperphosphatemia was completely inhibited by cimetidine but only partly by promethazine. However, the histamine-induced hypocalcemia was totally inhibited by cimetidine and promethazine.
mesh_terms: D000818:Animals; D002118:Calcium / Q000097:blood*; D002645:Chickens; D002927:Cimetidine / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000633:toxicity*; D006996:Hypocalcemia / Q000139:chemically induced* / Q000517:prevention & control; D010058:Oviposition; D010710:Phosphates / Q000097:blood*; D011398:Promethazine / Q000494:pharmacology
chemical_list: D010710:Phosphates; D002927:Cimetidine; D006632:Histamine; D011398:Promethazine; D002118:Calcium