Exacerbation of psychosis after discontinuation of carbamazepine treatment.
Carbamazepine alone or carbamazepine plus neuroleptic was administered to 20 chronic schizophrenic patients. Upon abrupt discontinuation two of the 20 patients had exacerbations of their psychoses characterized by paranoia, hostility, and agitation. The authors discuss the possibility of a carbamazepine withdrawal syndrome.
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
D014150:Antipsychotic Agents; D002220:Carbamazepine