Prevention of postoperative infection in cesarean section after rupture of the membranes.
Patients having a cesarean section more than 6 h after rupture of the membranes constitute a high risk group for postoperative infections. Two such groups were studied. Patients were given either cefuroxime 1.5 g every 8th hour for 24 h followed by cefadroxil 0.5 g twice daily for 6 days or received no medication. The infection rate was significantly reduced in the treatment group as compared to the control group (15% vs. 48%). Non-infected patients had a significantly shorter stay in hospital (8 days vs. 12 days). Combined use of these drugs for prevention of post-cesarean infection has not previously been reported. No side effects of the antibiotic prophylaxis were reported.
D002434:Cefadroxil / Q000627:therapeutic use*; D002444:Cefuroxime / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002585:Cesarean Section; D002986:Clinical Trials as Topic; D004716:Endometritis / Q000517:prevention & control; D005321:Extraembryonic Membranes; D005260:Female; D005335:Fever of Unknown Origin / Q000517:prevention & control; D006801:Humans; D007743:Labor, Obstetric; D011183:Postoperative Complications / Q000517:prevention & control; D011247:Pregnancy; D011292:Premedication; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013997:Time Factors
D002511:Cephalosporins; D002434:Cefadroxil; D002444:Cefuroxime