title: Changes of plasma insulin glucagon and somatostatin in portal blood and morphological changes of islets of Langerhans after hepatectomy in dogs.
abstract: Hybrid adult male dogs were laparotomized before, one week after and one month after 40% hepatectomy. At the same time, an intravenous glucose tolerance test was done (IV-GTT) and pancreatic tissues were removed and examined by PAP staining. The following results were obtained: Carbohydrate metabolism was disturbed and plasma insulin levels were low one week after surgery, but B-cell granulations was at the preoperative level. It seemed that hypersomatostatinemia suppressed insulin release from B cells. Carbohydrate metabolism was restored to normal and the plasma insulin response was increased one month after surgery. Islets of Langerhans cells were hypertrophic and increased after surgery, particularly D cells.
mesh_terms: D000818:Animals; D004285:Dogs; D005934:Glucagon / Q000097:blood*; D006498:Hepatectomy; D006984:Hypertrophy; D007328:Insulin / Q000097:blood*; D007515:Islets of Langerhans / Q000473:pathology*; D008115:Liver Regeneration; D011168:Portal System / Q000378:metabolism; D013004:Somatostatin / Q000097:blood*
chemical_list: D007328:Insulin; D013004:Somatostatin; D005934:Glucagon