Erythrocyte 3H-ouabain binding and digitalis treatment in ethanol addicted patients.
The binding of 3H-ouabain to human erythrocytes was analyzed in a population of hospitalized male ethanol addicted patients under long term digitalis treatment. In the non-alcoholic patient group the long term digitalis treatment induced an increase in Bmax and Kd values; such modification was not observed in the alcoholic patients. Chronic alcohol intake itself induced an increase in 3H-ouabain kinetic parameters. These observations confirm that ouabain binding to human erythrocytes is subject to pharmacological and toxicological regulation and that adaptive changes in peripheral tissues can be useful in predicting possible parallel modifications in other less accessible tissues.
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000097:blood*; D004071:Digitalis Glycosides / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010042:Ouabain / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*; D005723:gamma-Glutamyltransferase / Q000097:blood
D004071:Digitalis Glycosides; D010042:Ouabain; D005723:gamma-Glutamyltransferase; D000254:Sodium-Potassium-Exchanging ATPase