Microbial metabolism of phenelzine and pheniprazine.
Phenelzine and pheniprazine were used as substrates for metabolic studies with Cunninghamella echinulata and Mycobacterium smegmatis. Metabolites were identified by means of gas-liquid chromatography and mass spectrometry. 1-Acetyl-2-(2-phenylethyl)-hydrazine and 1-acetyl-2-(1-methyl-2-phenylethyl)hydrazine were the major products of C. echinulata metabolism of phenelzine and pheniprazine, respectively. In addition, M. smegmatis produced a second metabolite from each substrate; these metabolites were unequivocally identified as N-acetylphenylethylamine and N-acetylamphetamine from phenelzine and pheniprazine, respectively.
D000662:Amphetamines / Q000302:isolation & purification; D006834:Hydrazines / Q000378:metabolism*; D009090:Mucorales / Q000378:metabolism*; D009161:Mycobacterium / Q000378:metabolism*; D010624:Phenelzine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000378:metabolism*; D010627:Phenethylamines / Q000302:isolation & purification
D000662:Amphetamines; D006834:Hydrazines; D010627:Phenethylamines; C054572:1-acetyl-2-(1-methyl-2-phenylethyl)hydrazine; C054573:N-acetylamphetamine; C043198:N-acetylphenelzine; C054480:N-acetyl-2-phenylethylamine; D010624:Phenelzine