title: A study into possible deviation from the Hardy-Weinberg equilibrium by the alleles of the hypervariable sequence in the region of the human insulin gene.
abstract: A number of studies have reported on possible relationships between a hypervariable sequence near the 5' end of the insulin gene and some common diseases. Control populations within these studies appear to disobey the Hardy-Weinberg equilibrium. In this study we have ascertained the allele frequencies in 181 random individuals. The chi-squared statistic comparing this population with a theoretical Hardy-Weinberg population was 0.61. This makes it unlikely that in the general population the Hardy-Weinberg rule is disobeyed. Possible reasons for the discrepancy between our study and the studies of others are discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007328:Insulin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D007328:Insulin