[Are the antipsychotic and side-effects of neuroleptics imperfectly known?].
The influence of neuroleptics on central dopaminergic receptors is anatomically quite non-specific. Neuroleptics also have numerous pharmacological actions other than on dopamine. Taken together, these effects only explain some of the adverse reactions or drug interactions of neuroleptics and predict very poorly the treatment efficacy in given patients.
D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D004347:Drug Interactions; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010276:Parasympatholytics / Q000009:adverse effects; D011247:Pregnancy; D011379:Prognosis; D011605:Psychoses, Substance-Induced / Q000209:etiology; D011618:Psychotic Disorders / Q000188:drug therapy*; D011954:Receptors, Dopamine / Q000187:drug effects; D017448:Receptors, Dopamine D2
D014150:Antipsychotic Agents; D010276:Parasympatholytics; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2
L'action antipsychotique et les effets collatéraux des neuroleptiques sont-ils imparfaitement connus?