Effects of somatostatin antiserum on growth hormone levels in rats with periventricular lesions in the anterior hypothalamus.
To determine whether residual inhibitory control of growth hormone (GH) secretion in rats with lesions of the periventricular nucleus (PVN) and depleted median eminence content of somatostatin (SRIF) is due to SRIF, PVN-lesioned rats were treated with SRIF antiserum. Such treatment, in contrast to normal sheep serum, caused increased (P less than 0.0001) plasma GH in lesioned and control groups. These results indicate that biologically important amounts of SRIF are available in the PVN-lesioned rat.
D000818:Animals; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D007106:Immune Sera / Q000494:pharmacology*; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D051381:Rats; D013004:Somatostatin / Q000276:immunology*
D007106:Immune Sera; D013004:Somatostatin; D013006:Growth Hormone