Campylobacter pylori and recurrence of duodenal ulcers--a 12-month follow-up study.
In 39 patients with endoscopically healed duodenal ulcers repeat endoscopy and two antral biopsies after 1 year showed a relapse rate of 59%. Only post-treatment Campylobacter pylori status was a significant predictor of endoscopic relapse. 79% of patients who remained culture positive had a relapse, compared with 27% of culture-negative patients. Relapse was more likely (66%) in patients with a recurrence of C pylori after apparent eradication of the organism than in those who remained negative for C pylori (10%). No patient who remained negative for C pylori had histological gastritis, whereas all with recurrence of C pylori showed histological gastritis. These findings suggest an important role for C pylori in duodenal ulcer relapse in the year after treatment.
D000328:Adult; D002169:Campylobacter Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009942:Organometallic Compounds / Q000627:therapeutic use; D011446:Prospective Studies; D012008:Recurrence
D009942:Organometallic Compounds; C002791:bismuth tripotassium dicitrate