Differential displacement of opioids from plasma protein binding sites by di-isopropylfluorophosphate in the mouse.
Di-isopropylfluorophosphate (DFP) displaced the opioid drug, alfentanil, from plasma proteins in-vivo and in-vitro in mice but was without effect on the structurally related compound, fentanyl. This action probably accounts for the enhanced entry of alfentanil into the brain of DFP-treated animals and its enhanced antinociceptive activity.
D015760:Alfentanil; D000818:Animals; D001665:Binding Sites; D001798:Blood Proteins / Q000378:metabolism*; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000097:blood; D007531:Isoflurophate / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011485:Protein Binding
D001798:Blood Proteins; D007531:Isoflurophate; D015760:Alfentanil; D005283:Fentanyl