Effects of forskolin, isoproterenol and lithium ions on leucophores of a teleost, Oryzias latipes: evidence for involvement of adenylate cyclase in pigment-dispersion response.
Forskolin, a stimulator of adenylate cyclase, induced a dose-dependent and reversible dispersion of pigment within fish leucophores. Li+, known as an inhibitor of the enzyme, depressed pigment-dispersion response of leucophores to either forskolin or isoproterenol, inducing an aggregation of pigment within the cells. These results indicate that Li+ acted on the cells through inhibition of forskolin- or isoproterenol-stimulated adenylate cyclase activity. The results suggest that adenylate cyclase is involved in the pigment-dispersion response of leucophores and that cAMP acts as a second messenger in the response.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002856:Chromatophores / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D005576:Colforsin / Q000494:pharmacology*; D003532:Cyprinodontiformes / Q000502:physiology*; D003714:Denervation; D007545:Isoproterenol / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology*; D009990:Oryzias / Q000502:physiology*; D010860:Pigments, Biological / Q000378:metabolism*
D010860:Pigments, Biological; D005576:Colforsin; D008094:Lithium; D000262:Adenylyl Cyclases; D007545:Isoproterenol