Discriminative stimulus properties of (+/-)-3,4-methylenedioxymethamphetamine and (+/-)-3,4-methylenedioxyamphetamine in pigeons.
Pigeons trained to discriminate (+)-amphetamine (AMPH) from saline in a two-key food-maintained drug discrimination paradigm, were used to investigate the discriminative stimulus (DS) effects of two structural analogues of amphetamine, namely (+/-)-3,4-methylenedioxymethamphetamine (MDMA) and (+/-)-3,4-methylenedioxyamphetamine (MDA). After discrimination performance was stable (90% injection-appropriate responding), test sessions with various doses of AMPH were conducted and a dose-dependent relationship for AMPH-appropriate responding was obtained. Both MDMA (3.0 mg/kg) and MDA (3.0 or 5.6 mg/kg) substituted for AMPH; however, at these doses MDA produced a greater decrease in response rate compared to AMPH and MDMA. Furthermore, while MDMA and MDA were similar in potency in producing drug-appropriate responding, both were less potent than AMPH. These results indicate that MDMA and MDA have DS effects similar to AMPH in pigeons.
D015104:3,4-Methylenedioxyamphetamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000661:Amphetamine / Q000494:pharmacology; D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D010856:Columbidae; D004193:Discrimination Learning / Q000187:drug effects; D004192:Discrimination, Psychological / Q000187:drug effects*; D018817:N-Methyl-3,4-methylenedioxyamphetamine
D000662:Amphetamines; D015104:3,4-Methylenedioxyamphetamine; D000661:Amphetamine; D018817:N-Methyl-3,4-methylenedioxyamphetamine