Effect of somatostatin on histamine-stimulated gastric acid and pepsin secretion in dogs.
The purpose of the present study was to evaluate the effect of somatostatin on gastric acid secretion and pepsin secretion in conscious dogs with gastric fistula. Infusion of histamine stimulated dose-dependently the acid secretion, whereas pepsin secretion was decreased by the high doses of histamine. Somatostatin inhibited dose-dependently the stimulated acid secretion but only with a maximum of 40%. The pepsin secretion was inhibited by somatostatin dose-dependently and with a higher potency. The acid inhibition was of a competitive type and prostaglandin-independent.
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D007700:Kinetics; D010434:Pepsin A / Q000378:metabolism*; D013004:Somatostatin / Q000494:pharmacology*; D013270:Stomach / Q000502:physiology
D013004:Somatostatin; D006632:Histamine; D010434:Pepsin A