Clorgyline treatment differentially affects m-chlorophenylpiperazine-induced neuroendocrine changes.
Intravenous administration of the 5-HT1B agonist, m-chlorophenylpiperazine (m-CPP) to rats produced increases in plasma prolactin (peak effect at 15 min), corticosterone (peak effect at 30 min) and a decrease in plasma growth hormone (peak effect at 15 min) concentrations. Short-term or long-term clorgyline treatment did not affect baseline levels of prolactin, corticosterone or growth hormone. Short-term clorgyline treatment attenuated m-CPP's effect on corticosterone but not on prolactin or growth hormone. On the other hand, long-term clorgyline treatment attenuated m-CPP's effect on prolactin but not on corticosterone or growth hormone. These findings are compatible with development of functional subsensitivity of 5-HT1B receptors mediating prolactin release following long-term clorgyline treatment. Attenuation of m-CPP's effect on corticosterone following short-term clorgyline treatment suggests either early adaptational changes in a 5-HT receptor subtype mediating corticosterone release, or clorgyline-induced increases in other neurotransmitters such as norepinephrine which may be responsible for attenuating m-CPP's effect on corticosterone.
D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D003010:Clorgyline / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood*; D013006:Growth Hormone / Q000097:blood; D007275:Injections, Intravenous; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000378:metabolism; D010879:Piperazines / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood*; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects
D018377:Neurotransmitter Agents; D010879:Piperazines; D011437:Propylamines; D011985:Receptors, Serotonin; D011388:Prolactin; D013006:Growth Hormone; D003010:Clorgyline; C015068:1-(3-chlorophenyl)piperazine; D003345:Corticosterone