Orbital T-cell lymphoma in human T-cell leukemia virus-I infection.
This is the first report of orbital involvement in systemic adult T-cell leukemia/lymphoma (ATLL). The etiologic agent of ATLL is the human T-cell leukemia virus-I (HTLV-I), the first retrovirus demonstrated to induce cancer in humans. The diagnosis of ATLL is based on characteristic clinicopathologic features in combination with serologic or virologic evidence of HTLV-I infection. Serum antibodies to HTLV-I were identified by immunofluorescent microscopy. Viral particles characteristic of HTLV-I were found in a culture of the patient's peripheral blood lymphocytes. The patient was a native of the Caribbean, one of the known endemic foci of HTLV-I infection. Adult T-cell leukemia/lymphoma should be considered in the differential diagnosis of orbital T-cell lymphomas.
D000328:Adult; D001706:Biopsy; D006800:Deltaretrovirus Infections / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D009918:Orbital Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000648:ultrastructure; D013601:T-Lymphocytes; D014057:Tomography, X-Ray Computed