title: Skeletal muscle relaxant action of an aqueous extract of Portulaca oleracea in the rat.
abstract: The aqueous extract of Portulaca oleracea produced skeletal muscle relaxation in rats following i.p. or oral administration, as assessed by the prolongation of pull-up time. The i.p. route of administration was more effective. When compared with chlordiazepoxide (20 mg/kg, i.p.), diazepam (40 mg/kg, i.p.) and dantrolene sodium (30 mg/kg, oral), the extract (200-1000 mg/kg, i.p.) proved a more effective skeletal muscle relaxant. With 1000 mg/kg i.p., 80% lethality was seen. The LD50 in an acute toxicity test in mice was 1040 mg/kg i.p.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000633:toxicity; D001569:Benzodiazepines; D003620:Dantrolene / Q000494:pharmacology; D008519:Medicine, Traditional; D051379:Mice; D008807:Mice, Inbred BALB C; D009125:Muscle Relaxants, Central; D009549:Nigeria; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D014151:Anti-Anxiety Agents; D009125:Muscle Relaxants, Central; D010936:Plant Extracts; D001569:Benzodiazepines; D003620:Dantrolene