title: A pseudoautosomal gene in man.
abstract: The X/Y homologous gene MIC2 was shown to exchange between the sex chromosomes, thus demonstrating that it is a pseudoautosomal gene in man. MIC2 recombines with the sex-determining gene(s) TDF at a frequency of 2 to 3 percent. It is the most proximal pseudoautosomal locus thus far described and as such is an important marker for use in studies directed towards the isolation of TDF.
mesh_terms: D002874:Chromosome Mapping; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic; D012729:Sex Chromosome Aberrations / Q000235:genetics; D012732:Sex Determination Analysis; D014960:X Chromosome; D014998:Y Chromosome