[Antimetastatic effect of the delta-sleep peptide during stress in mice with Lewis' lung carcinoma].
The experiments on C57Bl mice with metastatic Lewis lung carcinoma have shown that peptide delta-sleep (DSIP) lowers the stimulation of metastatic spreading which is observed in combination of the surgical removal of the tumour with the emotional-painful stress. The antimetastatic effect is accompanied by stabilization of neurohumoral indices, by a decrease in the intensity of lipid peroxidation and of the acid cathepsin activity in the blood vessels and in the lung tissue.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002277:Carcinoma / Q000503:physiopathology*; D003701:Delta Sleep-Inducing Peptide / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D050356:Lipid Metabolism; D008175:Lung Neoplasms / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D018377:Neurotransmitter Agents / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D013315:Stress, Psychological / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
D018377:Neurotransmitter Agents; D003701:Delta Sleep-Inducing Peptide
Antimetastaticheskiĭ éffekt peptida del'ta-sna pri stresse u mysheĭ s kartsinomoĭ legkogo L'iuis.