Effects of morphine on adrenaline responses of uteri from progesterone or estradiol treated mice.
1. The effect of a chronic morphine treatment on the in vitro contractile responses of the mouse uterus to adrenaline was studied. 2. Chronic morphine treatment induced a supersensitivity state in the uteri from both progesterone and estradiol treated mice. 3. The acute administration of morphine to the uteri from morphine tolerant-dependent and progesterone treated mice induced a further increase of the contractile effect of adrenaline. 4. Reserpine administration did not further increase the supersensitivity of the mouse uterus to adrenaline induced by a chronic morphine treatment. 5. Reserpine suppressed the acute effects of morphine in the uteri from tolerant-dependent mice.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D004837:Epinephrine / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D011374:Progesterone / Q000494:pharmacology*; D012110:Reserpine / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects*
D011374:Progesterone; D004958:Estradiol; D009020:Morphine; D012110:Reserpine; D004837:Epinephrine