A mouse model to estimate the potency of the diphtheria component in combined vaccines.
A mouse model is presented to estimate the potency of the diphtheria component in combined vaccines. In addition, a simplified mouse test is suggested for routine potency control of diphtheria. It will be important to discuss this approach to replace the lethal challenge test in guinea pigs.
D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis; D001428:Bacterial Vaccines / Q000592:standards*; D001886:Bordetella pertussis / Q000276:immunology; D003017:Clostridium tetani / Q000276:immunology; D004168:Diphtheria Toxoid / Q000592:standards; D004306:Dose-Response Relationship, Immunologic; D051379:Mice; D011054:Poliovirus Vaccine, Inactivated / Q000592:standards*; D013223:Statistics as Topic
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D004168:Diphtheria Toxoid; D011054:Poliovirus Vaccine, Inactivated