title: Antihistamines and driving safety.
abstract: The results of two placebo-controlled driving performance studies confirm laboratory data showing that the nonsedating antihistamine terfenadine does not influence the driving performance of users. The amplitude of vehicle weaving calculated for drivers who received this agent did not differ from control values. Neither terfenadine nor loratadine, another nonsedating antihistamine, potentiated the adverse effects of alcohol on driving performance.
mesh_terms: D001334:Automobile Driving; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D003533:Cyproheptadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004311:Double-Blind Method; D000431:Ethanol / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D017336:Loratadine; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects; D016593:Terfenadine
chemical_list: D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D003533:Cyproheptadine; D000431:Ethanol; D017336:Loratadine; D016593:Terfenadine