title: Fluazifop, a grass-selective herbicide which inhibits acetyl-CoA carboxylase in sensitive plant species.
abstract: Fluazifop is a grass-selective herbicide that appears to act by inhibiting fatty acid synthesis de novo in sensitive species. Results from four different types of experiment show that this inhibition is due to an action of fluazifop on acetyl-CoA carboxylase and not on fatty acid synthetase. The acetyl-CoA carboxylase from sensitive barley (Hordeum vulgare), but not from resistant pea (Pisum sativum), is inhibited by the R stereoisomer, a finding that agrees with the herbicidal specificity of fluazifop.
mesh_terms: D000085:Acetates / Q000378:metabolism; D000103:Acetyl-CoA Carboxylase / Q000037:antagonists & inhibitors*; D002736:Chloroplasts / Q000187:drug effects / Q000201:enzymology; D004095:Dihydropyridines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000096:biosynthesis; D006540:Herbicides / Q000494:pharmacology*; D008025:Ligases / Q000037:antagonists & inhibitors*; D008316:Malonyl Coenzyme A / Q000378:metabolism; D010944:Plants / Q000187:drug effects* / Q000201:enzymology
chemical_list: D000085:Acetates; D004095:Dihydropyridines; D005227:Fatty Acids; D006540:Herbicides; D008316:Malonyl Coenzyme A; C050582:fluazifop; D008025:Ligases; D000103:Acetyl-CoA Carboxylase