Disposition of radiolabeled flumequine in rat and dog.
Single doses of 14C-flumequine (a urinary tract antibacterial) were given to rats and dogs. Unchanged drug accounted for more than 80% of the drug in plasma of rats but only 25-50% in plasma of dogs. Although only a small percentage of the dose was excreted in the urine of each species as unchanged drug, a wide differentiation in the urinary metabolite profiles was observed. No significant tissue retention was seen in rats or dogs.
D000818:Animals; D000892:Anti-Infective Agents, Urinary / Q000378:metabolism*; D001681:Biological Assay; D002855:Chromatography, Thin Layer; D004285:Dogs; D024841:Fluoroquinolones; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D011807:Quinolizines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013050:Spectrometry, Fluorescence; D014018:Tissue Distribution
D000892:Anti-Infective Agents, Urinary; D024841:Fluoroquinolones; D011807:Quinolizines; C012976:flumequine