Increase in glutamate sensitivity of subthalamic nucleus neurons following bilateral decortication: a microiontophoretic study in the rat.
Responses of subthalamic neurons (STN) to the iontophoretic application of glutamate (Glu), acetylcholine (ACh) and GABA were studied in rats 2 or 3 weeks following bilateral decortication, and were compared to those obtained in normal animals. All the cells recorded in lesioned rats showed a decrease in their spontaneous firing rate. They also proved to be significantly more sensitive to the excitatory action of Glu, although their responsiveness to ACh or GABA was not modified.
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials; D000818:Animals; D002541:Cerebral Decortication; D005917:Globus Pallidus / Q000502:physiology; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D007478:Iontophoresis; D051381:Rats; D013787:Thalamic Nuclei / Q000187:drug effects* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D005971:Glutamates; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine