Effect of terfenadine on the bronchoconstriction induced by ultrasonically nebulized distilled water.
Ultrasonically nebulized distilled water (UNDW) has been shown to induce bronchoconstriction in asthmatics. The proposed mechanism is through changes in osmolarity of the airway fluids and subsequent release of mediators from airway mast cells. We investigated whether terfenadine has a protective effect on UNDW challenges. Twelve mild-to-moderate asthmatics responded to screening a methacholine and UNDW challenge. For four hours after the ingestion of 0, 120, and 240 mg of terfenadine pulmonary responses were performed, followed by a UNDW challenge. Nine of 12 subjects dropped 20% after 120 mg and after 240 mg. There was a suggestion of a protective effect at 120 mg (P = .054), which was significant at 240 mg (P = .012) when the areas under the dose-response curves were compared. Bronchoconstriction induced by UNDW may in part be caused by histamine release and was attenuated by an oral antihistamine.
D000293:Adolescent; D000328:Adult; D001559:Benzhydryl Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D001985:Bronchial Provocation Tests / Q000379:methods; D001986:Bronchial Spasm / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D005541:Forced Expiratory Volume; D006634:Histamine H1 Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009330:Nebulizers and Vaporizers; D016593:Terfenadine; D014463:Ultrasonography
D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D016593:Terfenadine