[Clinical value of the determination of TSH-binding inhibitory immunoglobulins (TBII) by a radioreceptor assay].
The aim of the present study was to evaluate the clinical value of a commercial kit for determination of TBII. The study consisted of 50 patients with untreated Graves' disease, 21 patients with Graves' disease before und during medical therapy, 18 patients after finishing medical therapy and 10 patients after surgical treatment. Besides these, 41 patients with other thyroid diseases and 36 patients without any thyroid disorder were included. In 47 (94%) of 50 patients with untreated Graves' disease TBII were detectable in serum using a TSH-standard-curve. Binding activities exceeding 10 U/l TSH equivalents were regarded as positive. In other thyroid diseases TBII were negative with the exception of 3 of 22 patient with autonomously functioning thyroid nodules. After 12 months of antithyroid drug treatment of 19 patients the incidence of positive antibody findings was 26%. During follow-up after medical therapy (1-9 years) 7 of 18 patients had increased TBII in correlation with clinical and functional findings. The determination of TBII by TRAK-Assay proved to be a sensitive and specific method. The assay can be used to differentiate between hyperthyroidism of autoimmune or non-immunogenic origin. Even so this method seems to be helpful for the follow-up under medical treatment of patients with Graves' disease.
D001327:Autoimmune Diseases / Q000175:diagnosis; D005500:Follow-Up Studies; D006111:Graves Disease / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D018828:Immunoglobulins, Thyroid-Stimulating; D011863:Radioimmunoassay; D011869:Radioligand Assay; D013963:Thyroid Hormones / Q000097:blood
D007074:Immunoglobulin G; D018828:Immunoglobulins, Thyroid-Stimulating; D013963:Thyroid Hormones
Klinische Wertigkeit der Bestimmung von TSH-Bindungs-inhibierenden Immunglobulinen (TBII) durch einen Radiorezeptorassay.