Cross-reaction of two different somatostatin antisera with calcitonin gene-related peptide.
Two different anti-somatostatin antisera, R-101 and OAL-273, cross-react with rat calcitonin gene-related peptide (1-37) (CGRP). CGRP amounts, in excess of 6.25 x 10(-9) M, cross-react with R-101 in the somatostatin radioimmunoassay. CGRP amounts, in excess of 1.6 x 10(-9) M, cross-react with OAL-273. Both CGRP displacement curves are parallel to that of synthetic somatostatin (1-14). Comparison of ID50's shows that the cross-reactivity of CGRP with R-101 and OAL-273 are 0.02 and 0.1% of somatostatin, respectively.
D000595:Amino Acid Sequence; D000818:Animals; D002116:Calcitonin / Q000235:genetics*; D015740:Calcitonin Gene-Related Peptide; D003429:Cross Reactions; D006801:Humans; D007106:Immune Sera; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000276:immunology*; D051381:Rats; D012487:Salmonidae; D013004:Somatostatin / Q000276:immunology*; D013045:Species Specificity; D013329:Structure-Activity Relationship
D007106:Immune Sera; D009479:Neuropeptides; D013004:Somatostatin; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide