title: [Pathogenesis of Dupuytren's disease].
abstract: Liver studies performed in 47 patients with Dupuytren's contracture revealed a high level of hepatitis A contamination; in addition, procollagen III levels were distinctly lowered as compared to normal values, and liver enzyme values were pathologic in 32%. A disturbance of collagen metabolism must, therefore, be considered as a possible cause of Dupuytren's contracture.
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D003094:Collagen / Q000378:metabolism*; D004387:Dupuytren Contracture / Q000201:enzymology*; D006506:Hepatitis A / Q000150:complications; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D008111:Liver Function Tests; D010446:Peptide Fragments / Q000378:metabolism; D011347:Procollagen / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide; D003094:Collagen; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin
vernacular_title: Untersuchungen zur Genese der Dupuytrenschen Erkrankung.