Anticholinesterase activity of prolactin: correlation with analgesia.
The possible inhibitory effect of prolactin on serum cholinesterase activity has been examined. Prolactin given to mice inhibited the enzyme's activity in a dose-related fashion. This inhibition was not reversed by naloxone. A significant correlation was observed between the anticholinesterase and analgesic activity of prolactin. The findings suggest that prolactin may exert its cholinomimetic activity by inhibition of cholinesterase. A significant contribution by the cholinergic activity, which was independent of the opioid system, was indicated in the analgesic effect.
D000700:Analgesics; D000818:Animals; D002800:Cholinesterase Inhibitors; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009270:Naloxone / Q000494:pharmacology; D011388:Prolactin / Q000494:pharmacology*
D000700:Analgesics; D002800:Cholinesterase Inhibitors; D009270:Naloxone; D011388:Prolactin