On the binding of cinmetacin and indomethacin to human serum albumin.
The binding of two non-steroidal anti-inflammatory drugs, indomethacin and cinmetacin, to human serum albumin was studied by dynamic dialysis at 37 degrees C and pH 7.4. Cinmetacin is bound more than indomethacin. The affinity constant for the primary binding site is 4.28 X 10(6) M-1 for cinmetacin and 1.4 X 10(6) M-1 for indomethacin. The protein binding of indomethacin is decreased in the presence of cinmetacin.
D003956:Dialysis; D006801:Humans; D007210:Indoleacetic Acids / Q000097:blood*; D007213:Indomethacin / Q000097:blood*; D007700:Kinetics; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*
D007210:Indoleacetic Acids; D012709:Serum Albumin; C013887:cinmethacin; D007213:Indomethacin