[Changes in the activity of adenylate- and guanylate cyclase in different rat tissues after chronic administration of ACTH or cortisol].
The state of adenylate and guanylate cyclases in the adrenals, suprarenal fat and ventricular myocardium of the rat was studied under conditions of chronic administration of ACTH or cortisol. By the end of ACTH injections the weight of the adrenals and the DNA content in them increased 6 and 3 times, respectively; both parameters showed a gradual increase. The corticosteroid level in the blood changed throughout the experiment. The changes in the DNA content in the adrenals and in the corticosteroid level in the blood were oppositely directed. This was paralleled with cyclic changes in the basal and stimulated activities of adenylate and guanylate cyclases occurring with a periodicity of 15 days. The peaks of the cyclase activity preceded the increase in the DNA content. Similar cyclic changes in the enzyme activity were observed in the adipose tissue and myocardium. It was supposed that periodic changes in the cyclase activity are the main prerequisites for the growth and replication of cells under conditions of changed hormonal status of the organism.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000273:Adipose Tissue / Q000201:enzymology; D000311:Adrenal Glands / Q000201:enzymology; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D004789:Enzyme Activation; D006162:Guanylate Cyclase / Q000378:metabolism*; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000201:enzymology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013045:Species Specificity; D013997:Time Factors; D014018:Tissue Distribution
D000324:Adrenocorticotropic Hormone; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase; D006854:Hydrocortisone
Izmeneniia aktivnosti adenilat- i guanilattsiklazy v razlichnykh tkaniakh krys pri khronicheskom vvedenii AKTG ili kortizola.