Determination of carazolol in tissues of pigs by high-performance liquid chromatography.
A new and sensitive method is described for the determination of the beta-receptor blocker Carazolol, 4-(2-hydroxy-3-isopropylaminopropoxy)-carbazole, in different animal tissues. The procedure comprises extraction of Carazolol from tissue, clean-up by Kieselgel adsorption and high-performance liquid chromatographic separation with fluorimetric detection. The determination limit is 0.48 microgram/kg sample. The method has been verified by measuring Carazolol in liver, kidney and filet of a fattening pig treated with Carazolol before slaughtering.
D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D007202:Indicators and Reagents; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D009132:Muscles / Q000032:analysis; D011412:Propanolamines / Q000032:analysis*; D013552:Swine
D000319:Adrenergic beta-Antagonists; D007202:Indicators and Reagents; D011412:Propanolamines; C014382:carazolol