title: Somatostatin levels and binding in duodenal mucosa of rabbits with ligation of the pancreatic duct.
abstract: Atrophy of the exocrine pancreas was induced in rabbits by pancreatic duct ligation. Somatostatin concentration and binding in cytosol from rabbit duodenal mucosa were studied after 6 and 14 weeks of pancreatic duct ligation. Somatostatin-like immunoreactivity was significantly increased in the duodenal mucosa in both periods. Scatchard analysis showed a parallel increase in the number of binding sites rather than a change in their affinity. The physiological significance of these findings remains to be clarified.
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D003600:Cytosol / Q000378:metabolism; D004386:Duodenum / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D008026:Ligation; D008297:Male; D010179:Pancreas / Q000502:physiology*; D010183:Pancreatic Ducts; D011817:Rabbits; D013004:Somatostatin / Q000378:metabolism*
chemical_list: D013004:Somatostatin