Non-cholinergic, non-adrenergic nerve-mediated relaxation of pig and human detrusor muscle in vitro.
Previously unrecognised, nerve-mediated relaxation in pig and human detrusor muscle is described. The relaxation was mediated via non-cholinergic, non-adrenergic and non-prostaglandin transmitter or modulator systems and was present in 12 of 15 detrusor strips from six pigs and in four of 15 detrusor strips from seven patients. A contractile phase preceded relaxation in all strips; in contrast to the contractile phase, relaxation was augmented by an increase in basal tension in a complex way and possibly by the slowest stimulation frequencies.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology; D004558:Electric Stimulation; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction; D009126:Muscle Relaxation; D009132:Muscles / Q000502:physiology; D010276:Parasympatholytics / Q000494:pharmacology; D011930:Reaction Time; D013552:Swine
D000319:Adrenergic beta-Antagonists; D010276:Parasympatholytics