Evidence against leukotriene-mediation of propranolol-induced airway hyperreactivity to acetylcholine.
In unanaesthetized guinea-pigs, propranolol treatment (0.1 mg kg-1 i.v.) substantially increased reactivity to intravenous acetylcholine infusion or aerosolized histamine to a comparable degree. Neither BW755c (5 mg kg-1 i.v.), FPL 55712 (1 mg kg-1 i.v.), nor piriprost (5 mg kg-1 i.v.) pretreatment influenced propranolol's effect on muscarinic reactivity although BW755c abolished histaminic hyperreactivity. This suggests that propranolol-induced muscarinic hyperreactivity in the guinea-pig is not mediated by leukotrienes whereas histaminic hyperreactivity may be.
D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D000109:Acetylcholine / Q000494:pharmacology*; D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects; D002867:Chromones / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000494:pharmacology / Q000031:analogs & derivatives; D006168:Guinea Pigs; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology; D011968:Receptors, Histamine / Q000187:drug effects; D011976:Receptors, Muscarinic / Q000187:drug effects; D013189:SRS-A / Q000502:physiology*
D000893:Anti-Inflammatory Agents; D002867:Chromones; D011720:Pyrazoles; D011968:Receptors, Histamine; D011976:Receptors, Muscarinic; D013189:SRS-A; D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; C006312:FPL 55712; D011433:Propranolol; D011464:Epoprostenol; D000109:Acetylcholine; C035296:piriprost