An anabolic state in the heart induced by arginine intubation.
Using rat heart perfusion, we found that an anabolic state can be induced with a medium which includes glucose, carnitine, branched-chain amino acids and arginine after arginine intubation at a dose of 250 mg/kg body weight. It showed diminished levels of glutamine, glutamate, branched-chain oxoacids and phenylalanine (a marker of heart protein metabolism) release, reflecting anabolic changes occurring in the myocardium. While ornithine intubation caused a catabolic state in which the release of alanine and glutamate was increased but phenylalanine release was unchanged. This anabolic state may be a useful model providing for myocardial protection.
D000409:Alanine / Q000378:metabolism; D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009952:Ornithine / Q000494:pharmacology; D010477:Perfusion; D010649:Phenylalanine / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats
D005971:Glutamates; D011773:Pyruvates; D018698:Glutamic Acid; D010649:Phenylalanine; D019289:Pyruvic Acid; D001120:Arginine; D009952:Ornithine; D000409:Alanine