title: The oral disposition of zinc following the use of an anticalculus toothpaste containing 0.5% zinc citrate.
abstract: Zinc is retained in the mouth after use of a toothpaste containing 0.5% zinc citrate. More than one third of the dose was found to be retained after normal brushing. Elevated zinc levels were also found in plaque. Saliva zinc levels were significantly above background for at least 2 h after brushing. In-vitro experiments demonstrated that zinc can bind to the pellicle-coated tooth surface and can subsequently adsorb into saliva. Plaque can calcify to form calculus containing appreciable levels of hydroxyapatite. Zinc adsorbs to hydroxyapatite inhibiting crystal growth. Levels of zinc in plaque were found to be considerably higher than those taken up by hydroxyapatite in an in-vitro test of crystal growth inhibition indicating the potential of zinc to inhibit calculus formation.
mesh_terms: D000327:Adsorption; D002951:Citrates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019343:Citric Acid; D003460:Crystallization; D044622:Dental Pellicle; D003802:Dentifrices; D006801:Humans; D006882:Hydroxyapatites / Q000032:analysis; D012463:Saliva / Q000032:analysis; D014070:Tooth / Q000378:metabolism; D014100:Toothpastes; D015032:Zinc / Q000032:analysis / Q000493:pharmacokinetics*
chemical_list: D002951:Citrates; D003802:Dentifrices; D006882:Hydroxyapatites; D014100:Toothpastes; D019343:Citric Acid; D015032:Zinc