A review of the biochemical and neuropharmacological actions of lithium.
The pharmacological actions central to the therapeutic effects of lithium have not yet been established, despite almost 40 years of clinical use and scientific investigation. We review the biochemical and neuropharmacological data relating to this problem and attempt to identify profitable areas for further research.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D004723:Endorphins / Q000378:metabolism; D006801:Humans; D008094:Lithium / Q000494:pharmacology*; D009420:Nervous System / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D004723:Endorphins; D018377:Neurotransmitter Agents; D008094:Lithium; D000262:Adenylyl Cyclases; D000254:Sodium-Potassium-Exchanging ATPase