Production of climbing behaviour in mice requires both D1 and D2 receptor activation.
The ability of SKF38393 (a D1 agonist), quinpirole (a D2 agonist), and apomorphine (a mixed D1/D2 agonist) to induce stereotyped climbing behaviour in mice was investigated. Apomorphine produced a dose-related increase in stereotyped cage climbing which lasted for up to 60 min. SKF38393 and quinpirole failed to produce climbing when administered alone. When given in combination intense apomorphine-like cage climbing was observed which lasted for up to 2 h. Apomorphine or the combination of SKF38393 and quinpirole also produced biting of the cage. The climbing behaviour produced by either apomorphine or SKF38393/quinpirole combinations was antagonised by either the D1 antagonist, SCH23390 or the D2 antagonist clebopride. These results demonstrate that both D1 and D2 receptor activation is necessary to produce apomorphine-like cage climbing in mice.
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001058:Apomorphine / Q000494:pharmacology; D001067:Appetite Depressants / Q000494:pharmacology; D001552:Benzazepines / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004873:Ergolines / Q000494:pharmacology; D005260:Female; D051379:Mice; D019257:Quinpirole; D011954:Receptors, Dopamine / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects*
D014150:Antipsychotic Agents; D001067:Appetite Depressants; D001552:Benzazepines; D004873:Ergolines; D011954:Receptors, Dopamine; D019257:Quinpirole; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D001058:Apomorphine