title: Prospective trial of operative versus non-operative treatment of severe vesicoureteric reflux in children: five years' observation. Birmingham Reflux Study Group.
abstract: Children with severe vesicoureteric reflux were allocated randomly to either operative or non-operative treatment and followed up. Altogether 161 children were observed for two years, of whom 104 were followed up for five years. Reflux was abolished in 98% of ureters reimplanted, but more than half of the patients treated non-operatively continued to show severe reflux at five years. Two patients progressed to end stage renal failure, and a further four with extensive bilateral renal scarring became hypertensive. There were no significant differences between treatment groups in the incidence of breakthrough urinary infection, renal excretory function and concentrating ability, renal growth, progression of existing renal scars, or new scar formation. Progressive scarring occurred at all ages but was significantly more common during the first two years' observation. Furthermore, new scars developed exclusively during the first two years' observation, affecting 10 children aged 2-7 at allocation. Neither treatment can claim superiority or fully protect the kidneys from further damage, and efforts must continue to be directed towards identifying those at risk before scarring develops.
mesh_terms: D000293:Adolescent; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D002921:Cicatrix / Q000473:pathology; D002986:Clinical Trials as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D007674:Kidney Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008297:Male; D011183:Postoperative Complications / Q000209:etiology; D011446:Prospective Studies; D011897:Random Allocation; D014513:Ureter / Q000601:surgery; D014718:Vesico-Ureteral Reflux / Q000150:complications / Q000601:surgery / Q000628:therapy*
chemical_list: D000892:Anti-Infective Agents, Urinary