title: Blockade by neuroleptics of water intake and operant responding for water in the rat: anhedonia, motor deficit, or both?
abstract: Four different neuroleptic drugs, haloperidol, metoclopramide, sulpiride and cis-flupenthixol, were tested for their ability to attenuate an operant lever-pressing response with water as reward and the corresponding consummatory act, i.e., the non-conditioned water intake. All four neuroleptic drugs tested more potently attenuated the operant lever-pressing response than the consummatory water intake, just as the conditioned avoidance response previously has been found to be more potently attenuated than the non-conditioned escape reaction. The results suggest that a certain class of learned behaviors, labelled operant or instrumental behaviors, are more susceptible to the attenuating effects of neuroleptic drugs than the class of behaviors labelled non-conditioned consummatory acts. It was further concluded that the attenuation of the lever-pressing response could be explained by a decreased ability of the animals to initiate or perform the required operant response (i.e., a motor deficit) while the attenuated water intake caused by higher doses of the neuroleptics could be interpreted as a motivational effect (e.g., "anhedonia"). When studying the effects of the neuroleptic drugs it is therefore of great importance to know whether the behavior measured in the particular experimental design used is operant or consummatory. The implications of the findings are discussed.
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D003259:Consummatory Behavior / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D009042:Motivation / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013469:Sulpiride / Q000494:pharmacology
chemical_list: D014150:Antipsychotic Agents; D013469:Sulpiride; D006220:Haloperidol; D008787:Metoclopramide