Diagnosis of cervical neoplasia by the estimation of octadeca-9,11-dienoic acid.
Exfoliated cells from the precancerous cervix have an increased concentration of octadeca-9,11-dienoic acid, a diene-conjugated isomer of linoleic acid. A high-performance liquid chromatographic method which measures both has been automated. It may form the basis of a sensitive diagnostic test.
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003127:Colposcopy; D005069:Evaluation Studies as Topic; D005231:Fatty Acids, Unsaturated / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009994:Osmolar Concentration; D002583:Uterine Cervical Neoplasms / Q000032:analysis / Q000175:diagnosis* / Q000473:pathology; D014626:Vaginal Smears
D005231:Fatty Acids, Unsaturated; C027369:octadecadienoic acid