Sequence analysis of the matrix protein gene of human parainfluenza virus type 3: extensive sequence homology among paramyxoviruses.
The sequences of the human parainfluenza virus type 3 (PIV3) matrix (M) mRNA [1150 nucleotides exclusive of poly(A)] and predicted M protein (353 amino acids) were determined by sequence analysis of cloned cDNA and viral genomic RNA. The gene-end sequence of the M gene differed from the semi-conserved gene-end sequence of the other PIV3 genes by an apparent insertion of eight nucleotides. The PIV3 M protein shared high sequence homology with Sendai virus and moderate homology with measles virus and canine distemper virus. Statistical analysis of the available sequences showed that the M protein was the most highly conserved parainfluenza viral protein.
D000595:Amino Acid Sequence; D001483:Base Sequence; D005796:Genes; D005814:Genes, Viral; D010224:Parainfluenza Virus 3, Human / Q000235:genetics*; D010252:Paramyxoviridae / Q000235:genetics*; D010802:Phylogeny; D011061:Poly A / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D018108:Respirovirus / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014763:Viral Matrix Proteins; D014764:Viral Proteins / Q000235:genetics*
D012333:RNA, Messenger; D012367:RNA, Viral; D014763:Viral Matrix Proteins; D014764:Viral Proteins; D011061:Poly A