Effect of prostaglandin PGE2 on alcohol-induced ulceration in the rat colon.
The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon. Only prostaglandin E2 treatment significantly reduced mucosal ulceration. Long-term exposure of the rat colon to topical ethanol produced some of the histological changes seen in human colitis.
D000818:Animals; D003108:Colonic Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D015232:Dinoprostone; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D011239:Prednisolone / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012460:Sulfasalazine / Q000494:pharmacology; D014456:Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control
D011458:Prostaglandins E; D000431:Ethanol; D012460:Sulfasalazine; D011239:Prednisolone; D015232:Dinoprostone