Fibrinogen and fibrin: biochemistry and pathophysiology.
Fibrinogen is a thrombin-coagulable glycoprotein occurring in the blood of vertebrates. The primary structure of the alpha, beta, and gamma polypeptide chains of human fibrinogen is known from amino acid and nucleic acid sequencing. The intact molecule has a trinodular, dimeric structure and is functionally bivalent. Thrombin cleaves short peptides from the amino termini of the alpha and beta chains exposing polymerization sites that are responsible for the formation of fibrin fibers and appearance of a clot. The major physiological function of fibrinogen is the formation of fibrin that binds together platelets and some plasma proteins in a hemostatic plug. In pathological situations, the network entraps large numbers of erythrocytes and leukocytes forming a thrombus that may occlude a blood vessel. Fibrinogen and fibrin are multifunctional proteins. Fibrinogen is indispensable for platelet aggregation; it also binds to several plasma proteins, however, the biological function of this interaction is not completely understood. Fibrin is an essential matrix for regulation of fibrinolysis and for facilitation of cell attachment in wound healing.
D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal; D001777:Blood Coagulation; D001798:Blood Proteins / Q000378:metabolism; D002241:Carbohydrates / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D004220:Disulfides / Q000032:analysis; D005337:Fibrin / Q000502:physiology*; D005340:Fibrinogen / Q000502:physiology*; D005341:Fibrinolysin / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D046911:Macromolecular Substances; D010447:Peptide Hydrolases / Q000378:metabolism; D011108:Polymers; D011487:Protein Conformation; D011503:Transglutaminases / Q000378:metabolism
D000911:Antibodies, Monoclonal; D001798:Blood Proteins; D002241:Carbohydrates; D004220:Disulfides; D046911:Macromolecular Substances; D011108:Polymers; D005337:Fibrin; D005340:Fibrinogen; D011503:Transglutaminases; D010447:Peptide Hydrolases; D005341:Fibrinolysin