title: HLA-DR alpha, -DX alpha, and DR beta III gene association studies in DR3 individuals.
abstract: In this study we have examined the results of probing with synthetic oligomers at the DR beta III locus, together with restriction fragment length polymorphisms defined by BglII digestion and a cDNA DR alpha probe, and Taq 1 digestion and a genomic DQ alpha probe. We have demonstrated heterogeneity of the human leukocyte antigen DR3 and close association of the DR alpha, DR beta III, and DX alpha genes. Two DR3-related preferential allelic associations have been identified, which may prove useful in family analysis as well as for investigations of DR3-related diseases.
mesh_terms: D000483:Alleles; D002446:Celiac Disease / Q000235:genetics / Q000276:immunology; D004247:DNA / Q000235:genetics; D003874:Dermatitis Herpetiformis / Q000235:genetics / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D015803:HLA-DR3 Antigen; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D011487:Protein Conformation
chemical_list: D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; D015803:HLA-DR3 Antigen; C051104:HLA-DR52 antigen; C040626:HLA-Dx antigen; D004247:DNA