Intrathecal sufentanil as a supplement to subarachnoid anaesthesia with lignocaine.
The combination of low-dose sufentanil with lignocaine for subarachnoid anaesthesia was studied in a double-blind comparative trial in 40 urological patients. Patients were allocated randomly to two groups and received 5% heavy lignocaine 1.5 ml together with either 1.5 ml of sufentanil 5 micrograms ml-1, or physiological saline 1.5 ml. No statistically significant differences were observed between the two groups with respect to analgesia or anaesthesia. The only clear benefit of the addition of a low dose of sufentanil to lignocaine was the significantly longer period of postoperative analgesia. There was no significant difference in the number of patients requiring supplementary analgesics. Side-effects were similar in both groups.
D000759:Adjuvants, Anesthesia; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000701:Analgesics, Opioid / Q000494:pharmacology; D000775:Anesthesia, Spinal; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D017409:Sufentanil; D013997:Time Factors
D000759:Adjuvants, Anesthesia; D000701:Analgesics, Opioid; D008012:Lidocaine; D017409:Sufentanil; D005283:Fentanyl