Multiple type-beta transforming growth factors and their receptors.
Type beta transforming growth factors are a group of homologous structurally related polypeptides that act on a wide variety of cell types to alter their proliferative and phenotypic properties. TGF-beta s form a group within a larger family of polypeptides that control developmental processes in organisms from humans to Drosophila. We have found that at least three distinct forms of TGF-beta are present in mammalian tissues. We have identified a family of cell surface glycoproteins that bind TGF-beta s with high affinity and specificity. Examination of the interactions between individual forms of TGF-beta and the individual TGF-beta receptor species has illustrated a complex pattern of ligand-receptor associations. Occupancy of a particular receptor type by TGF-beta can be correlated to the dictation of specific effects on cell proliferation and cell differentiation.
D000595:Amino Acid Sequence; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004347:Drug Interactions; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000494:pharmacology / Q000502:physiology*; D010641:Phenotype; D011956:Receptors, Cell Surface / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D018125:Receptors, Transforming Growth Factor beta; D013329:Structure-Activity Relationship; D015291:Transforming Growth Factors
D010455:Peptides; D011956:Receptors, Cell Surface; D018125:Receptors, Transforming Growth Factor beta; D015291:Transforming Growth Factors