Preparation of influenza B virus recombinant strains.
The study of antigenic and biologic properties of influenza B epidemic viruses isolated in 1979 and 1983 and laboratory strain B/Lee/40 has revealed some differences in their biologic properties. The most marked changes have been found in the haemagglutinin (HA) and neuraminidase (NA) indicating that influenza B viruses underwent dramatic antigenic drifts during the period in question. The strains obtained by genetic recombination have inherited surface antigens of epidemic influenza B/Singapore/222/79 and B/USSR/100/83 viruses and preserved the HA thermolability inherent to these viruses. They have, however, acquired the marker of reproduction in chick embryos and the immunogenicity from the donor strain B/Lee/40. These recombinants can be, therefore, recommended as vaccine strain candidates.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000956:Antigens, Viral / Q000276:immunology*; D002642:Chick Embryo; D006168:Guinea Pigs; D009981:Influenza B virus / Q000235:genetics / Q000254:growth & development / Q000276:immunology* / Q000472:pathogenicity; D007252:Influenza Vaccines / Q000276:immunology; D051379:Mice; D051381:Rats; D011995:Recombination, Genetic; D013696:Temperature; D014614:Vaccines, Synthetic / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007252:Influenza Vaccines; D014614:Vaccines, Synthetic