Assessment of sensitivity of Trypanosoma congolense to isometamidium chloride: a comparison of tests using cattle and mice.
The sensitivities of 3 strains of Trypanosoma congolense to isometamidium chloride (Samorin) were determined in mice and cattle, with the objective of evaluating sensitivity testing in mice as a means of predicting curative doses in cattle. Comparison of mouse effective dose 80% (ED80) or curative dose 80% (CD80) values with cattle minimum curative dose (MCD) values demonstrated a wide variation between trypanosome strains. Although a mouse test may give a broad indication of the sensitivity of a strain, it cannot be used to predict curative doses for cattle. It was concluded that care should be exercised in extrapolating the results of a mouse test to cattle.
D000818:Animals; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D010617:Phenanthridines / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014348:Trypanosoma congolense / Q000187:drug effects*; D014353:Trypanosomiasis, African / Q000188:drug therapy; D014354:Trypanosomiasis, Bovine / Q000188:drug therapy*
D010617:Phenanthridines; D014344:Trypanocidal Agents; C000702:isometamidium chloride