Comparative study of rat-paw oedema tests for assessing reactivity of B. pertussis-containing combined vaccines.
Two volumetric (electrocapacity plethysmography and mercury volumetry) and two linear methods (a new type of scale and a calliper rule) for rat-paw oedema measurement used in local reactivity of combined vaccines containing a B. pertussis component were compared. The reproducibility and sensitivity of the methods was tested on a diphtheria-tetanus-pertussis vaccine and a toxic pertussis suspension. The linear methods proved more adequate for measuring small and chiefly unidirectionally (vertically) progressing oedemas.
D000818:Animals; D001886:Bordetella pertussis; D004168:Diphtheria Toxoid / Q000633:toxicity*; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations / Q000633:toxicity; D004487:Edema / Q000209:etiology; D005260:Female; D008297:Male; D010567:Pertussis Vaccine / Q000633:toxicity*; D010991:Plethysmography; D051381:Rats; D011919:Rats, Inbred Strains; D013745:Tetanus Toxoid / Q000633:toxicity*; D010566:Virulence Factors, Bordetella / Q000633:toxicity*
D004168:Diphtheria Toxoid; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid; D010566:Virulence Factors, Bordetella