[Influence of rations with various linoleic acid contents on the fatty acid composition of phospholipids in blood platelets of rats].
Gas-liquid chromatography was used to study the fatty-acid composition of phospholipids in platelets of Wistar-Kioto rats which received semisynthetic rations with varying content of linoleic acid, 1 week prenatally and 18 weeks postnatally. In ration I the level of 18:2n6 was lower than 0.1 cal%, ration II contained 9.0 cal%, and ration III -- 16.0 cal%. Ration III, as compared to ration II, induced an increase in the content of linoleic fatty acids, arachidonic fatty acid content being unchanged. Ration I, as compared to ration II induced a decrease in linoleic fatty acid content, and an increase in the content of oleic and linolenic fatty acids attended by the appearance of appreciable amounts of 20:3n9 and 20:5n3. Long-term linoleic acid deficiency induced no changes in the unsaturation degree of fatty acids in platelet phospholipids of rats given ration I. This is an evidence of high reserve possibilities of the mechanisms regulating fatty acid metabolism in the mammals.
D000818:Animals; D001792:Blood Platelets / Q000032:analysis*; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000097:blood*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology*; D008042:Linolenic Acids / Q000097:blood; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000097:blood; D010743:Phospholipids / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D017962:alpha-Linolenic Acid
D004041:Dietary Fats; D005227:Fatty Acids; D008041:Linoleic Acids; D008042:Linolenic Acids; D009829:Oleic Acids; D010743:Phospholipids; D017962:alpha-Linolenic Acid; D019301:Oleic Acid; D019787:Linoleic Acid
Vliianie ratsionov s razlichnym soderzhaniem linolevoĭ kisloty na zhirno-kislotnyĭ sostav fosfolipidov trombotsitov krys.