Glucocorticoid-induced vasoconstriction in human skin. An inhibitory role on phospholipase A2 activity.
The ability of topically applied betamethasone valerate to reduce erythema produced by a variety of vasodilators was assessed. The steroid significantly reduced the erythema induced by topical arachidonic acid, intradermal histamine, and compound 48/80. We postulated that the steroid reduced endogenous phospholipase activity either before or after application of the vasodilators, or both. This action may explain the mechanism of glucocorticoid-induced vasoconstriction in the skin and part of the steroids' action in acute inflammatory skin disease.
D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors; D001624:Betamethasone Valerate / Q000494:pharmacology; D005260:Female; D005938:Glucocorticoids; D006634:Histamine H1 Antagonists; D006801:Humans; D008297:Male; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D012867:Skin / Q000098:blood supply / Q000187:drug effects* / Q000201:enzymology; D014661:Vasoconstriction / Q000187:drug effects*; D003189:p-Methoxy-N-methylphenethylamine / Q000037:antagonists & inhibitors
D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D005938:Glucocorticoids; D006634:Histamine H1 Antagonists; D016718:Arachidonic Acid; D003189:p-Methoxy-N-methylphenethylamine; D001624:Betamethasone Valerate; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2