Properties of glycine-activated conductances in rat brain neurones.
The inhibitory responses to glycine, taurine, beta-alanine, 2-amino-5-phosphonovaleric acid (APV) were investigated in freshly isolated neurones from medulla oblongata and hippocampus of rat using concentration clamp, voltage clamp and intracellular perfusion techniques. All substances, when applied in a steplike manner, induced a rapid increase in the chloride permeability of the cellular membrane which slowly desensitized. The responses to all substances were blocked by external strychnine. Cross-desensitization experiments demonstrated that all substances tested activate the same system of membrane receptors.
D015763:2-Amino-5-phosphonovalerate; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D005998:Glycine / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D009431:Neural Conduction / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D013654:Taurine / Q000494:pharmacology; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology; D015091:beta-Alanine / Q000494:pharmacology
D000927:Anticonvulsants; D015091:beta-Alanine; D013654:Taurine; D015763:2-Amino-5-phosphonovalerate; D014633:Valine; D005998:Glycine