Stimulant action of pethidine on the pregnant rat uterus in-vitro.
Pethidine's stimulant action on the 22-day pregnant rat isolated uterus does not involve receptors sensitive to methysergide and is unlikely to involve the synthesis and release of endogenous prostaglandins. The sensitivity of pethidine-induced contractions to verapamil suggests that mobilization of extracellular calcium is necessary for pethidine's action.
D000818:Animals; D004347:Drug Interactions; D005260:Female; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008614:Meperidine / Q000494:pharmacology*; D008784:Methysergide / Q000494:pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D014590:Uterine Contraction / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology
D008614:Meperidine; D014700:Verapamil; D007213:Indomethacin; D008784:Methysergide