Graves' disease of the beta cell: glucose dysregulation due to islet-cell stimulating antibodies.
The immunoglobulin fractions of serum from patients with spontaneous hyperinsulinaemic hypoglycaemia and others with type 1 diabetes stimulated insulin release both in islet-cell cultures and in vivo in rats. Serum from patients with type 2 diabetes, which is not an autoimmune disease, did not stimulate insulin release. The discovery of islet-cell-stimulating antibodies (ICSTA) completes for the islet the triad of autoantibodies (anticytoplasmic, antiproduct, and antireceptor) previously described in autoimmune thyroid disease. ICSTA may be important modulators of islet-cell secretion in man.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001786:Blood Glucose / Q000032:analysis; D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D006224:Cricetinae; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006111:Graves Disease / Q000276:immunology; D006801:Humans; D006946:Hyperinsulinism / Q000276:immunology; D007003:Hypoglycemia / Q000276:immunology; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007330:Insulin Antibodies / Q000276:immunology; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains
D001323:Autoantibodies; D001786:Blood Glucose; D007328:Insulin; D007330:Insulin Antibodies; C024211:islet cell antibody; C057691:islet-cell-stimulating antibodies