title: [Dale's principle and the one neuron-one transmitter concept].
abstract: Dale's principle was first proposed by Eccles in 1954 based on 3 lectures given by Dale in 1934 and 1952. Many authors in the literature define Dale's principle as the "one neuron-one transmitter concept". The origin of such an idea, however, is rather vague. Neither Dale nor Eccles stated literally the one neuron-one transmitter concept. It seems now appropriate to define Dale's principle according to Eccles (1976) as follows: "at all the axonal branches of a neuron there is liberation of the same transmitter substance or substances". Recent studies showed examples that are not in accord with the "one neuron-one transmitter concept". Many cases were shown in which a neuron contains more than one transmitter. Whether this is a common rule or exceptional remains to be clarified by future studies.
mesh_terms: D006801:Humans; D009474:Neurons / Q000032:analysis / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000032:analysis* / Q000502:physiology
chemical_list: D018377:Neurotransmitter Agents