title: The heterogeneity of arylsulphatase-A and arylsulphatase-B in normal human urine and urine from cancer patients.
abstract: Arylsulphatase-A and arylsulphatase-B heterogeneity in normal and cancer patient urine was investigated using high resolution agarose isoelectricfocusing. Normal urine contained up to nine forms of arylsulphatase-A activity with isoelectric points from 4.45 to 5.43 and at least 5 forms of arylsulphatase-B between 8.58 and 9.15 along with a broad zone of activity between pH 6.5 and 7.6. Although cancer patients had significantly higher levels of arylsulphatase-A and arylsulphatase-B activity, their pattern of activity was essentially the same as for the normals with only minor quantitative differences in some peaks.
mesh_terms: D002553:Cerebroside-Sulfatase / Q000652:urine*; D002803:Chondro-4-Sulfatase / Q000652:urine*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007525:Isoelectric Focusing; D009369:Neoplasms / Q000201:enzymology* / Q000652:urine; D013429:Sulfatases / Q000652:urine*
chemical_list: D013429:Sulfatases; D002553:Cerebroside-Sulfatase; D002803:Chondro-4-Sulfatase