Autonomic effects on protein secretion by rat submandibular salivary glands.
1. Following treatment with cholinergic and beta-adrenergic drugs, the beta-type protein, associated with cAMP, was secreted regardless of the doses used. 2. Following treatment with alpha 1-adrenergic drugs, both the beta-type and alpha-type proteins were secreted depending on the doses used and the alpha-type protein was completely converted to the beta-type with alpha-blockers. 3. Following treatment with alpha 2-adrenergic drugs, the gamma-type protein, associated with cGMP, was secreted independent of the doses used.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D008297:Male; D011506:Proteins / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012463:Saliva / Q000378:metabolism; D012967:Sodium Dodecyl Sulfate; D013363:Submandibular Gland / Q000378:metabolism*
D000316:Adrenergic alpha-Agonists; D000596:Amino Acids; D011506:Proteins; D012967:Sodium Dodecyl Sulfate; D000242:Cyclic AMP; D006152:Cyclic GMP