Phenobarbital: a locus of action on spike broadening and potassium inactivation.
1. The effect of phenobarbital on frequency-dependent spike broadening and potassium inactivation was studied in snail neurons. 2. The amount of spike broadening was significantly depressed by the application of 10(-3) M phenobarbital but the time course of broadening was unaffected. 3. In voltage clamped neurons, this concentration of phenobarbital significantly depressed the amount of potassium current inactivation without altering its time constant. 4. A possible locus of phenobarbital's anticonvulsant action is through a decrease in synaptic efficacy resulting from a depression of presynaptic spike broadening.
D000818:Animals; D004558:Electric Stimulation; D006372:Helix, Snails / Q000502:physiology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology*; D011188:Potassium / Q000037:antagonists & inhibitors* / Q000378:metabolism
D011188:Potassium; D010634:Phenobarbital