Postnatal development of amino acid metabolism enzymes in the liver and muscle of 'cafeteria' rats.
The effect of feeding a high-energy highly palatable cafeteria diet on the liver and muscle ontogenesis of serine dehydratase, alanine transaminase, glutamine synthetase and adenylate deaminase during postnatal development of the rat has been studied. The results are in agreement with the lower amino acid utilization in cafeteria rats, both adults and during postnatal development. The feeding of excess energy coupled with high-quality protein resulted in changes in the ontogenesis of the studied enzymes that coincide with the development of protein synthesis and overall pup growth even before they had direct access to this rich diet, suggesting that cafeteria feeding already affects the amino acid metabolism of the pup through the dam's milk.
D000659:AMP Deaminase / Q000378:metabolism; D000410:Alanine Transaminase / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D004032:Diet; D005260:Female; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism; D012695:L-Serine Dehydratase / Q000378:metabolism; D008099:Liver / Q000201:enzymology* / Q000254:growth & development; D024510:Muscle Development; D009132:Muscles / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D000410:Alanine Transaminase; D000659:AMP Deaminase; D012695:L-Serine Dehydratase; D005974:Glutamate-Ammonia Ligase