Evidence of an estrogen-like effect of dehydroepiandrosterone on lysyl oxidase activity in the mouse cervix.
The effect of dehydroepiandrosterone (DHA) on the lysyl oxidase activity in the mouse cervix was studied. Injection of animals ovariectomized 10 days before with 1 mg DHA was followed 24 h later by an increase in enzyme activity, which remained unaltered for 48 h, returning to control values by 96 h after injection. At least 100 micrograms of DHA was required to increase enzyme activity; the maximum effect occurred with 1 mg of the steroid and was comparable to that of 1 microgram estradiol-17 beta. These results demonstrate an estrogen-like effect of DHA on lysyl oxidase activity in mouse cervix. The onset of response was later and the duration of response was longer for DHA than for estradiol-17 beta.
D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000818:Animals; D002584:Cervix Uteri / Q000187:drug effects / Q000201:enzymology*; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D010052:Ovariectomy; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism*
D003687:Dehydroepiandrosterone; D000594:Amino Acid Oxidoreductases; D008249:Protein-Lysine 6-Oxidase