title: Gastric mucus glycoprotein in different rat strains.
abstract: The extent of gastric damage induced by aspirin was found to differ according to rat strain. The occurrence of ulcers varied, from high to low, in the following strain order: Donryu, Sprague-Dawley (SD) and Wistar. The content of corpus mucus glycoprotein was essentially the same in all the strains: about 6 mg as hexose of dry tissue. Antral mucus glycoprotein content increased in the order Wistar, SD and Donryu: 7.1, 8.3 and 9.1 mg, respectively. Gastric mucus glycoprotein carbohydrate composition was essentially the same in all three strains. The relatively low proportions of N-acetylglucosamine, galactose and sialic acid from the antrum was a characteristic feature in contrast to mucus glycoprotein from the corpus which contained a high proportion of these sugars.
mesh_terms: D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D002241:Carbohydrates / Q000032:analysis; D006023:Glycoproteins / Q000378:metabolism*; D008297:Male; D009093:Mucus / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013276:Stomach Ulcer / Q000139:chemically induced
chemical_list: D002241:Carbohydrates; D006023:Glycoproteins; D001241:Aspirin