The oral clearance of zinc and triclosan after delivery from a dentifrice.
Oral delivery and retention of zinc and triclosan were measured in man after use of an anti-plaque dentifrice containing these antibacterial agents. Triclosan (25% of the dose) and zinc (24%) were retained in the mouth immediately after toothbrushing and a single mouthrinse. Salivary concentrations fell from 7.5 micrograms g-1 (triclosan) and 7.0 micrograms g-1 (zinc) after 5 min to 0.5 micrograms g-1 (triclosan) and 1.2 micrograms g-1 (zinc), 2 h after brushing.
D000328:Adult; D003802:Dentifrices; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D009055:Mouth / Q000378:metabolism*; D009067:Mouthwashes; D010647:Phenyl Ethers / Q000378:metabolism*; D012463:Saliva / Q000032:analysis; D014099:Toothbrushing; D014100:Toothpastes; D014260:Triclosan / Q000008:administration & dosage / Q000378:metabolism*; D015032:Zinc / Q000008:administration & dosage / Q000378:metabolism*
D003802:Dentifrices; D009067:Mouthwashes; D010647:Phenyl Ethers; D014100:Toothpastes; D014260:Triclosan; D015032:Zinc