Heavy metal-induced inhibition of active transport in the rat small intestine in vitro. Interaction with other ions.
The effect of Hg2+, Cd2+ and Pb2+ on the intestinal transport of D-glucose and L-tyrosine was studied in everted sacs of small intestine. Hg2+, Cd2+ and Pb2+ (10(-5) and 10(-4)) singly or in combination inhibit the active transport of D-glucose (10 mM) and L-tyrosine (2 mM) in rat and pigeon small intestine. The presence of other ions (Mg2+, Zn2+ and SeO3(2)) diminishes the toxic effect of heavy metal ions, rendering them less effective.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002104:Cadmium / Q000494:pharmacology*; D010856:Columbidae; D004336:Drug Antagonism; D005260:Female; D005947:Glucose / Q000378:metabolism; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D007854:Lead / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D008628:Mercury / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D020887:Selenious Acid; D012643:Selenium / Q000494:pharmacology; D013045:Species Specificity; D014443:Tyrosine / Q000378:metabolism; D015032:Zinc / Q000494:pharmacology
D002104:Cadmium; D007854:Lead; D014443:Tyrosine; D020887:Selenious Acid; D008628:Mercury; D012643:Selenium; D008274:Magnesium; D005947:Glucose; D015032:Zinc