Separation of racemic pharmaceuticals by high-performance liquid chromatography on silica gel modified with carbohydrate residues.
Derivatives of 2-amino-2-deoxyglucose covalently connected to aminopropyl-silica gel were used as chiral selectors in the separation of racemic pharmaceuticals. beta-Receptor blockers, adrenergic drugs and compounds with secondary amino functions could be separated after appropriate derivatization.
D000319:Adrenergic beta-Antagonists / Q000302:isolation & purification; D002241:Carbohydrates; D002851:Chromatography, High Pressure Liquid; D005944:Glucosamine; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations / Q000302:isolation & purification*; D058428:Silica Gel; D012822:Silicon Dioxide; D013237:Stereoisomerism; D013566:Sympathomimetics / Q000302:isolation & purification
D000319:Adrenergic beta-Antagonists; D002241:Carbohydrates; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D013566:Sympathomimetics; D058428:Silica Gel; D012822:Silicon Dioxide; D005944:Glucosamine