Tamoxifen inhibits 5-lipoxygenase in human polymorphonuclear leucocytes.
Breast cancer patient survival is increased by tamoxifen, and we therefore need to understand how this drug exerts its effect. We describe a novel action of tamoxifen, the inhibition of LTB4 and 5-HETE production from [14C]-arachidonic acid by human polymorphonuclear leucocytes.
D001091:Arachidonate Lipoxygenases / Q000037:antagonists & inhibitors*; D006801:Humans; D016859:Lipoxygenase Inhibitors; D009504:Neutrophils / Q000201:enzymology*; D013629:Tamoxifen / Q000494:pharmacology*
D016859:Lipoxygenase Inhibitors; D013629:Tamoxifen; D001091:Arachidonate Lipoxygenases