Prostatic carcinoma with endocrine features. A report of a neoplasm containing multiple immunoreactive hormonal substances.
A case of prostatic carcinoma with the cellular patterns of an adenocarcinoma and carcinoid tumor is reported. The tumor contained ultrastructural dense core neuroendocrine granules, and immunoperoxidase staining revealed prostatic acid phosphatase, prostatic-specific antigen, chromogranin, neuron-specific enolase, serotonin, adrenocorticotrophic hormone (ACTH), somatostatin, parathormone, calcitonin, bombesin, and glucagon but no insulin. The patient had exhibited hypercalcemia that may have been related to hormone production by the tumor. The literature on the endocrine aspect of the prostate and its tumor is reviewed.
D000230:Adenocarcinoma / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000368:Aged; D002116:Calcitonin / Q000032:analysis; D002276:Carcinoid Tumor / Q000473:pathology; D005934:Glucagon / Q000032:analysis; D006729:Hormones, Ectopic / Q000032:analysis*; D006801:Humans; D008297:Male; D009384:Paraneoplastic Endocrine Syndromes / Q000473:pathology; D010281:Parathyroid Hormone / Q000032:analysis; D011471:Prostatic Neoplasms / Q000032:analysis / Q000473:pathology*; D012701:Serotonin / Q000032:analysis; D013004:Somatostatin / Q000032:analysis
D006729:Hormones, Ectopic; D010281:Parathyroid Hormone; D012701:Serotonin; D013004:Somatostatin; D000324:Adrenocorticotropic Hormone; D002116:Calcitonin; D005934:Glucagon