Discriminative stimulus properties of phenylisopropylamine derivatives.
The phenylisopropylamine unit is a common structural fragment amongst many centrally-acting agents. However, these agents do not necessarily produce similar behavioral effects in test subjects. For example, the phenylisopropylamine derivative amphetamine is a central nervous system (CNS) stimulant whereas its 2,5-dimethoxy-4-methyl analog, i.e. DOM, is considered to be a hallucinogen. Employing animals trained to discriminate either (+)-amphetamine or (+/-)-DOM from saline in a two-lever operant procedure, stimulus generalization studies were conducted to evaluate members of a series of methoxy-substituted, and related, phenylisopropylamines. In this manner, it was possible to classify these agents as to which produced amphetamine-like effects, and which produced DOM-like effects.
D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine / Q000494:pharmacology; D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D000697:Central Nervous System Stimulants; D055598:Chemical Phenomena; D002621:Chemistry; D003216:Conditioning, Operant; D003463:Cues; D003913:Dextroamphetamine / Q000494:pharmacology; D004193:Discrimination Learning; D005795:Generalization, Stimulus; D006213:Hallucinogens; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D000470:Alkaloids; D000697:Central Nervous System Stimulants; D006213:Hallucinogens; D011437:Propylamines; D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine; C023665:cathinone; D003913:Dextroamphetamine