Defenestration of hepatic sinusoids as a cause of hyperlipoproteinaemia in alcoholics.
The hepatic sinusoidal endothelium separates sinusoidal blood from hepatocytes; changes in the porosity of this endothelium may affect the passage of chylomicrons into hepatocytes and influence lipid metabolism. Chronic exposure to ethanol reduces the porosity of the endothelium; this mechanism may underlie the hyperlipoproteinaemia observed in some people who drink heavily.
D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000150:complications / Q000473:pathology; D001707:Biopsy, Needle; D002196:Capillaries / Q000648:ultrastructure; D002463:Cell Membrane Permeability; D004727:Endothelium / Q000648:ultrastructure; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood / Q000209:etiology* / Q000473:pathology; D008055:Lipids / Q000097:blood; D008099:Liver / Q000098:blood supply* / Q000648:ultrastructure
D008055:Lipids