[Stimulation, by acute inflammation, of the proliferation in preneoplastic hepatocyte foci expressing the gamma glutamyl transpeptidase, induced by diethylnitrosamine in adult rats].
Acute inflammation induces 20% of hepatocytes to initiate a mitotic cycle in 10 day-old rats but only 1% in adults. gamma GT-positive cell foci were induced by diethylnitrosamine in the liver of adult rats. Proliferation of gamma GT-positive hepatocytes was increased by the acute inflammation that followed a subcutaneous injection of an irritating substance, but proliferation in the surrounding liver tissue remained at the low control level. This difference of sensitivity to the mitogenic stimulation, which mimics the difference between the sensitivity of hepatocytes in suckling and adult rats, gives gamma GT-positive hepatocytes a proliferative advantage over normal cells. Acute inflammation may thus promote the evolution of preneoplastic foci and hepatoma formation.
D000208:Acute Disease; D000818:Animals; D002364:Caseins / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004052:Diethylnitrosamine; D007249:Inflammation / Q000139:chemically induced / Q000201:enzymology*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology*; D011230:Precancerous Conditions / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D002364:Caseins; D004052:Diethylnitrosamine; D005723:gamma-Glutamyltransferase
Stimulation, par inflammation aiguë, de la prolifération dans les foyers d'hépatocytes prénéoplasiques exprimant la gamma-glutamyl transpeptidase, induits par la diéthylnitrosamine chez le rat adulte.