Alterations in ornithine decarboxylase and transglutaminase activities in lymphocytes from untreated patients with chronic lymphocytic leukemia.
Ornithine decarboxylase (L-ornithine carboxylase, EC 4.1.1.17) and transglutaminase (R-glutaminylpeptide: amine gamma-glutamyltransferase, EC 2.3.2.13), enzymes implicated in the regulation of growth processes, were studied in lymphocytes from untreated patients with chronic lymphocytic leukemia. A marked increase of ornithine decarboxylase activity was found in lymphocytes from chronic lymphocytic leukemia patients when compared to normal human lymphocytes; in contrast, no transglutaminase activity was found in lymphocytes from untreated patients with chronic lymphocytic leukemia.
D002454:Cell Differentiation; D006801:Humans; D007945:Leukemia, Lymphoid / Q000201:enzymology*; D008214:Lymphocytes / Q000201:enzymology*; D009363:Neoplasm Proteins / Q000032:analysis*; D009955:Ornithine Decarboxylase / Q000032:analysis*; D011503:Transglutaminases / Q000032:analysis* / Q000172:deficiency
D009363:Neoplasm Proteins; D011503:Transglutaminases; D009955:Ornithine Decarboxylase