Alpha-blocker, bunazosinhydrochloride decreases cytosolic Ca++ of cultured rat aortic smooth muscle cells.
Effect of alpha-blocker, bunazosinhydrochloride on cytosolic Ca++ concentration of rat aortic smooth muscle cells (SMC) was studied. Marked and sustained decrease in cytosolic Ca++ concentration of SMC was observed following the addition of 10(-7) M bunazosinhydrochloride. Furthermore, 10(-7) M bunazosinhydrochloride completely blocked the phenylephrine induced increase in cytosolic Ca++ of rat aortic SMC. It is of interest that a decrease in cytosolic Ca++ of vascular SMC was caused by alpha-blocker.
D000317:Adrenergic alpha-Antagonists; D000818:Animals; D001011:Aorta; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D003600:Cytosol / Q000378:metabolism; D007700:Kinetics; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D010656:Phenylephrine / Q000494:pharmacology; D011799:Quinazolines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000317:Adrenergic alpha-Antagonists; D011799:Quinazolines; D010656:Phenylephrine; C018176:bunazosin; D002118:Calcium