[Potential clinical use of an acid-stable proteinase inhibitor from human urine].
The method for the preparation of a specific proteinase adsorbent (acid-resistant human urinary proteinase inhibitor--UPI--immobilized on sepharose) has been developed. Proteinase adsorption using this adsorbent has proved highly effective in the treatment of acute pancreatitis with plasmasorption. High adsorption capacity of UPI-sepharose from plasma samples of patients with acute nonspecific aortoarteritis has been demonstrated in vitro. Determination of UPI activity in the human urine is an informative test for early tissue damage, as compared to plasma middle molecules assay. The former test may be used as a diagnostic technique in patients with parenchymal kidney injury and increased arterial pressure.
D000208:Acute Disease; D000328:Adult; D000818:Animals; D001025:Aortitis / Q000201:enzymology / Q000628:therapy; D001167:Arteritis / Q000201:enzymology / Q000628:therapy; D004285:Dogs; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004355:Drug Stability; D005260:Female; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D010179:Pancreas / Q000201:enzymology; D010195:Pancreatitis / Q000201:enzymology / Q000628:therapy; D010447:Peptide Hydrolases / Q000097:blood; D011480:Protease Inhibitors / Q000302:isolation & purification / Q000627:therapeutic use* / Q000652:urine; D012685:Sepharose; D013625:Takayasu Arteritis / Q000201:enzymology / Q000628:therapy
D011480:Protease Inhibitors; D012685:Sepharose; D010447:Peptide Hydrolases
Vozmozhnosti klinicheskogo primeneniia kislotostabil'nogo ingibitora proteinaz iz mochi cheloveka.