title: Lesions to Schaffer collaterals prevent ischemic death of CA1 pyramidal cells.
abstract: The contribution of excitatory inputs to CA1 pyramidal cell death after ischemia was examined using rats with unilateral destruction of CA3 pyramidal cells. Intracerebroventricular injection of L-alpha-kainic acid (KA) was performed before the induction of transient forebrain ischemia. Five days after ischemic insult, pyramidal cells and L-glutamate binding sites in the CA1 region ipsilateral to the KA injection were preserved in spite of neuronal necrosis and a significant decrease in L-glutamate receptor density in the contralateral CA1 region, indicating the critical role of Schaffer collaterals in delayed neuronal death.
mesh_terms: D000818:Animals; D001665:Binding Sites; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D006624:Hippocampus / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005971:Glutamates; D018698:Glutamic Acid; D007608:Kainic Acid