L-glutamate and N-methyl-D-asparatate actions on membrane potential and conductance of cat abducens motoneurones.
The actions of L-glutamate and N-methyl-D-aspartate (NMDA) were studied with intracellular recordings from cat abducens motoneurones. Amino acids were electrophoresed extracellularly from the same 7-barreled electrode types as those used in the spinal cord. Depolarization development, conductance changes and firing pattern induced by amino acids were very similar to those described for spinal motoneurones. The shape of NMDA depolarization suggests a uniform distribution of the involved receptors on the membrane of the motoneurone.
D000010:Abducens Nerve / Q000187:drug effects / Q000502:physiology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D002415:Cats; D004553:Electric Conductivity; D005971:Glutamates / Q000502:physiology*; D018698:Glutamic Acid; D008564:Membrane Potentials / Q000187:drug effects; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology*; D016202:N-Methylaspartate; D009431:Neural Conduction / Q000187:drug effects
D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid; D016202:N-Methylaspartate