Plasma growth hormone in acromegalic patients. Demonstration of highly reproducible diurnal profiles in individual patients.
The effects of the selective alpha 2-adrenoreceptor antagonist idazoxan on diurnal variations in plasma growth hormone levels were studied in acromegalic patients. Seven patients entered the study; six patients had been unsuccessfully treated with either pituitary adenotomy, bromocriptine or other drug therapy or a combination of the two procedures. Plasma growth hormone levels were measured at hourly intervals over a period of 24 h under control conditions and following 4 days treatment with either placebo or idazoxan (20 mg po, three times a day); the comparison of idazoxan with placebo was a double blind cross-over study. Except in one patient, the diurnal growth hormone plasma profiles were virtually superimposable under control conditions and following either placebo or idazoxan; each patient had a characteristic profile. Four patients had impressive nocturnal elevations ranging from about 40 to 200 per cent above average daytime levels. Only one had definite paradoxical early postprandial peaks. These observations are contrary to accepted views on growth hormone levels in acromegalic patients. The majority of our patients thus had profiles reminiscent of the normal diurnal plasma growth hormone pattern albeit at a higher level indicating some preserved central drive. The rather high prevalence in the present study of patients having relapses after adenomectomy may indicate that a selection had been made of cases with hypothalamic aetiology. Administration of the selective alpha 2-adrenoreceptor antagonist idazoxan did not modify plasma growth hormone profiles in these patients.
D000172:Acromegaly / Q000097:blood*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000328:Adult; D002940:Circadian Rhythm; D004146:Dioxanes / Q000494:pharmacology; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D019329:Idazoxan; D008297:Male; D008875:Middle Aged
D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D013006:Growth Hormone; D019329:Idazoxan