Functional recovery in a rat model of Parkinson's disease following transplantation of cultured human sympathetic neurons.
Rats subjected to a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion of the nigrostriatal dopamine pathway were given transplants of cultured fetal human sympathetic neurons. Amphetamine-induced turning behavior in these rats was reversed by the transplants after 1.5-4.5 months. The presence of transplanted neurons and their processes was demonstrated by immunohistochemistry for tyrosine hydroxylase.
D000661:Amphetamine; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D002478:Cells, Cultured; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D005333:Fetus; D005728:Ganglia, Sympathetic / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D006801:Humans; D006892:Hydroxydopamines; D016627:Oxidopamine; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000503:physiopathology*; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D002395:Catecholamines; D006892:Hydroxydopamines; D016627:Oxidopamine; D000661:Amphetamine; D014446:Tyrosine 3-Monooxygenase