title: A new method for measuring the free fraction of cyclosporin in plasma by equilibrium dialysis.
abstract: The free fraction of cyclosporin in plasma has been measured by equilibrium dialysis in steel chambers. Equilibration time was 16 h. The intra-assay coefficient of variation was 7%. The free fraction remained constant in plasma samples frozen for up to 6 months, and was independent of the total concentration within the therapeutic range.
mesh_terms: D000327:Adsorption; D003524:Cyclosporins / Q000097:blood*; D003956:Dialysis / Q000295:instrumentation; D006801:Humans
chemical_list: D003524:Cyclosporins