Differential effects of selective brain lesions on hypothalamic and pituitary ir-dynorphin.
Selective radiofrequency and neurotoxic lesions of the serotonergic pathways caused in the rat a significant reduction of ir-dynorphin A and B in the hypothalamus but not at pituitary level. These data confirm that dynorphin-related peptides are regulated independently in these areas.
D000818:Animals; D001921:Brain / Q000502:physiology*; D004399:Dynorphins / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D011903:Raphe Nuclei / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D004399:Dynorphins