Effect of oestrogen and testosterone implants on psychological disorders in the climacteric.
In a double-blind trial oestradiol, oestradiol/testosterone, or placebo implants were assessed for their effects on psychological symptoms in women attending a menopause clinic. After two months, women receiving active treatment scored better than the placebo group on a self-rating scale of distress, on anxiety, and on depression (p less than 0.05). Postmenopausal but not perimenopausal women improved after placebo, and at 4 months the scores in the three groups no longer differed significantly.
D000328:Adult; D002979:Climacteric / Q000523:psychology*; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy; D004311:Double-Blind Method; D004343:Drug Implants; D004958:Estradiol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009497:Neurotic Disorders / Q000188:drug therapy*; D011581:Psychological Tests; D013739:Testosterone / Q000008:administration & dosage / Q000627:therapeutic use*
D004343:Drug Implants; D013739:Testosterone; D004958:Estradiol