Polyclonal lymphocytosis of T-cells associated with human T-cell leukemia virus I.
A patient with antibodies to human T-cell leukemia virus type I and the presence of integrated sequences of this virus in T-lymphocytes was investigated. In contrast to previous reports, the T-cell lymphocytosis was found to be polyclonal by analysis of human T-cell leukemia virus type I integration sites and T-cell antigen receptor rearrangements. Polyclonal T-cell infection by human T-cell leukemia virus type I may represent an infrequently observed stage of leukemogenesis.
D000368:Aged; D004279:DNA, Viral / Q000032:analysis; D017977:Deltaretrovirus / Q000235:genetics*; D006800:Deltaretrovirus Infections / Q000150:complications; D005260:Female; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000032:analysis; D007938:Leukemia / Q000209:etiology; D008218:Lymphocytosis / Q000276:immunology / Q000382:microbiology*; D011533:Proviruses / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes / Q000382:microbiology*
D004279:DNA, Viral; D007132:Immunoglobulin Isotypes; D011948:Receptors, Antigen, T-Cell