Effects of somatostatin on self-stimulation behaviour in rats pretreated with a receptor blocker.
The effects of somatostatin on lateral hypothalamic self-stimulation were investigated in rats pretreated with haloperidol, bicuculline, phenoxybenzamine or propranolol. Somatostatin decreased the rate of self-stimulation. Halperidol, bicuculline and phenoxybenzamine potentiated the somatostatin-induced depression of self-stimulation behaviour. Propranolol had no effect. It is suggested that dopaminergic, GABAergic and noradrenergic systems are involved in the somatostatin-induced depression of self-stimulation.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012653:Self Stimulation / Q000187:drug effects*; D013004:Somatostatin / Q000494:pharmacology*
D010643:Phenoxybenzamine; D013004:Somatostatin; D011433:Propranolol; D006220:Haloperidol; D001640:Bicuculline