[Sensitivity of rat hepatocytes to phenobarbital after a single dose of N-nitrosodiethylamine in the embryonal and postnatal period or after partial hepatectomy].
For the hepatocarcinogenesis initiation one-fold N-nitrosodiethylamine (NDENA) action upon the livers of embryos and of the 4-weeks rats, before or after partial hepatectomy was used. Phenobarbital and repeated partial hepatectomies were used as the promotive factors. The promotion effect was evaluated by the quantity and size of hyperplastic liver nodules, where gamma-glutamyltranspeptidase activity was revealed. It was determined, that NDENA-affected rat liver cells in the embryonic period or at the age of 4 weeks after single partial hepatectomy proved to be more sensitive to the action of promoters.
D000818:Animals; D004052:Diethylnitrosamine; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006498:Hepatectomy; D006965:Hyperplasia; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000201:enzymology; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000096:biosynthesis
D004052:Diethylnitrosamine; D005723:gamma-Glutamyltransferase; D010634:Phenobarbital
Chuvstvitel'nost' k deĭstviiu fenobarbitala gepatotsitov krys posle odnokratnogo vvedeniia N-nitrozodiétilamina v émbrional'nom, postnatal'nom periode ili posle chastichnoĭ gepatéktomii.