title: Quantitative distribution of the glycine receptor in the auditory brain stem of the gerbil.
abstract: The concentration and relative distribution of glycine receptors were determined for gerbil brain stem auditory nuclei using 3H-strychnine and quantitative autoradiographic techniques. Significant binding was observed in the anteroventral cochlear nucleus, the dorsal cochlear nucleus, the lateral superior olivary nucleus, and the inferior colliculus. A non-uniform distribution of binding was seen in 3 of these nuclei, such that the greatest concentration of glycine receptors was located in the high-frequency regions. An analysis of neuron soma density suggested that the amount of post-synaptic membrane could partially explain the distribution of receptor.
mesh_terms: D000818:Animals; D001345:Autoradiography; D001933:Brain Stem / Q000032:analysis*; D004594:Electrophysiology; D005260:Female; D005849:Gerbillinae / Q000254:growth & development*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D007700:Kinetics; D008297:Male; D009847:Olivary Nucleus / Q000032:analysis*; D018009:Receptors, Glycine; D017981:Receptors, Neurotransmitter / Q000032:analysis*; D012016:Reference Values; D013331:Strychnine / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005971:Glutamates; D018009:Receptors, Glycine; D017981:Receptors, Neurotransmitter; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D013331:Strychnine