Analysis of idiotypic and anti-idiotypic antibodies as models of receptor and ligand.
Antibodies to small bioactive ligands and peptides may mimic the binding characteristics of the natural receptor; in turn, the anti-idiotypic antibodies generated against the binding sites of such anti-ligand antibodies may mimic some aspects of small bioactive ligands and peptides. Among the several levels of investigation of such antibody-receptor networks are (a) the quantitative structure-activity relationships of ligand binding to antibody as compared with natural receptor; (b) the molecular modeling of antibody-receptor binding sites and the genomic basis for such structures; and (c) the characteristics of the molecular mimicry exhibited by "mimetopes" on anti-idiotypic antibodies. To illustrate the analysis encountered at each of these levels, we discuss here antibody and anti-idiotypic systems that are directed to small neuroactive ligands and their receptors.
D000595:Amino Acid Sequence; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000235:genetics / Q000276:immunology; D000941:Antigens / Q000276:immunology; D014150:Antipsychotic Agents / Q000276:immunology; D001483:Base Sequence; D001666:Binding Sites, Antibody; D003198:Computer Simulation; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008954:Models, Biological; D011955:Receptors, Drug; D013329:Structure-Activity Relationship
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D000941:Antigens; D014150:Antipsychotic Agents; D007130:Immunoglobulin Idiotypes; D011955:Receptors, Drug