Hormonal regulation of preputial gland function in male Microtus montanus, the montane vole.
1. Preputial gland function in male Microtus montanus is androgen-dependent, both in terms of preputial weights and in the production of a series of lipids which are present in M. montanus and absent from Microtus pennsylvanicus. 2. Production of these species-typical lipids is decreased but not eliminated in castrates, as well as in adrenalectomized castrates treated with corticosterone. Therefore, in the total absence of androgens, a low level of these lipids is still produced. 3. 5 alpha-dihydrotestosterone and 17 beta-estradiol enanthate have limited effects on maintenance of preputial weight, suggesting that testosterone itself is the active steroid in the preputial gland of this species.
D000315:Adrenalectomy; D000818:Animals; D003411:Arvicolinae / Q000502:physiology*; D001835:Body Weight; D013196:Dihydrotestosterone / Q000494:pharmacology*; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D010413:Penis / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D012627:Sebaceous Glands / Q000187:drug effects / Q000502:physiology*; D013739:Testosterone / Q000494:pharmacology*
D013196:Dihydrotestosterone; D013739:Testosterone; D004958:Estradiol; C002027:estradiol enanthate