title: Stereoselectivity of central alpha-adrenoceptors involved in sleep induced by clonidine in chickens.
abstract: The stereoselectivity of central alpha 2-adrenoceptors involved in sleep induced in chicks by clonidine, suggested by the results observed with the stereoisomers of idazoxan, was further investigated with the stereoisomers of (imidazolinyl-2)-2-dihydro-2,3-benzofurane (S9871) and those of (imidazolinyl-2)-2-benzocyclobutane (S10089). As for the stereoisomers of idazoxan, there was not a good separation between the effects of the stereoisomers of S10089. In contrast, there was a clearcut separation between the effects of (+)S9871 (antagonist) and (-)S9871 (no effect against the action of clonidine). Therefore, these results strongly support the view that central alpha 2-adrenoceptors which mediate sedation are stereoselective for alpha 2-antagonists.
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001572:Benzofurans / Q000494:pharmacology; D002645:Chickens; D003000:Clonidine / Q000494:pharmacology*; D005260:Female; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D012018:Reflex / Q000187:drug effects; D012890:Sleep / Q000187:drug effects*; D013237:Stereoisomerism
chemical_list: D000317:Adrenergic alpha-Antagonists; D001572:Benzofurans; D007093:Imidazoles; D011942:Receptors, Adrenergic, alpha; C042254:S 9871; C043651:2-benzocyclobutane-4,5-dihydro-1-H-imidazole; D003000:Clonidine