[Characteristics of the anxiolytic action of benzodiazepine and GABA derivatives on experimentally modelled anxiety states].
The anxiolytic effect of seduxen was revealed in rats in experimentally modelled anxiety states formed by aversive actions of various biological importance. Phenibut and baclofen were found to display no anxiolytic properties on the anxiety model during a conflict situation. The revealed differences of the anxiolytic effect of derivatives of benzodiazepine and GABA indicate diverse spectra of their psychotropic activity.
D000818:Animals; D014151:Anti-Anxiety Agents; D001007:Anxiety / Q000188:drug therapy*; D001418:Baclofen / Q000627:therapeutic use*; D003220:Conflict, Psychological; D003975:Diazepam / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D004924:Escape Reaction / Q000187:drug effects; D008297:Male; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D014151:Anti-Anxiety Agents; D005680:gamma-Aminobutyric Acid; D001418:Baclofen; D003975:Diazepam; C008842:4-amino-3-phenylbutyric acid
Osobennosti anksioliticheskogo deĭstviia nekotorykh proizvodnykh benzodiazepina i GAMK na éksperimental'no modeliruemye sostoianiia trevogi.