Effects of minaprine, a novel antidepressant, on prolactin secretion in the rat.
The effect of minaprine, a novel psychotropic drug with antidepressant properties, on prolactin secretion has been investigated in the rat. On intraperitoneal administration (10 and 20 mg kg-1) it significantly decreased basal prolactin levels. In contrast, both haloperidol (1 mg kg-1 i.p.) and morphine (20 mg kg-1 i.p.) increased serum prolactin levels and daily treatment with oestradiol (100 micrograms kg-1 s.c.) for 4 days also elevated the levels. Minaprine at a dose of 20 mg kg-1 failed to antagonize the elevation of serum prolactin levels induced by these drugs. The results imply that minaprine may not exert a direct inhibitory action on prolactin secretion at the pituitary gland.
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D009020:Morphine / Q000494:pharmacology; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011724:Pyridazines / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000928:Antidepressive Agents; D011724:Pyridazines; C006149:minaprine; D004958:Estradiol; D009020:Morphine; D011388:Prolactin; D006220:Haloperidol