Effects of hexavalent chromium on trout mitochondria.
Trout liver mitochondria were incubated in the presence of micromolar concentration of potassium dichromate (Cr(VI)) under several experimental conditions. Cr(VI) strongly inhibited both state 3 and state 4 of respiration supplemented by NAD-linked substrates; it also slightly affected the respiration of FAD-linked substrates. Evidence is provided that the respiratory inhibition induced by dichromate is partially coupled to the Cr(VI) reduction mechanism occurring in mitochondria.
D000818:Animals; D002840:Chromates / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D011192:Potassium Dichromate / Q000378:metabolism / Q000494:pharmacology*; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid; D014337:Trout
D002840:Chromates; D005971:Glutamates; D013386:Succinates; D018698:Glutamic Acid; D019802:Succinic Acid; D011192:Potassium Dichromate