The use of deoxyribonucleic acid probes in the evaluation of hemophilia.
The use of deoxyribonucleic acid (DNA) probes is an important addition to existing laboratory methods for detection of carriers of hemophilia A and B. Both intragenic probes and probes directed at DNA restriction fragment length polymorphisms linked to the disease locus are now available. This technology will aid in genetic counseling of affected families and will impact upon clinical laboratory science in the near future.
D004247:DNA / Q000032:analysis / Q000235:genetics*; D004262:DNA Restriction Enzymes; D005164:Factor IX / Q000235:genetics; D005169:Factor VIII / Q000235:genetics; D006580:Genetic Carrier Screening; D006467:Hemophilia A / Q000175:diagnosis / Q000235:genetics*; D002836:Hemophilia B / Q000175:diagnosis; D006801:Humans; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length
D005169:Factor VIII; D005164:Factor IX; D004247:DNA; D004262:DNA Restriction Enzymes