Reduction of suppressor cell activities of human peripheral blood lymphocytes by a streptococcal preparation, OK-432.
The effect of a streptococcal preparation, OK-432 on suppressor cell activities of peripheral blood lymphocytes was investigated. Suppressor cell activities were significantly reduced when they were generated in vitro by concanavalin A (Con A) in the presence of OK-432. However, the reduction of suppressor cell activities was not observed when OK-432 was added in the effector phase. Similarly, a significant reduction of prostaglandin E2 (PGE2)-induced suppressor cell activities by OK-432 was observed. No increases of either T-cells with Fc receptors for IgG or OKT8 reactive T-cells were observed after Con A stimulation in the presence of OK-432. The suppressive effect of the soluble suppressor factors (SSF) was not abrogated by OK-432 and the release of SSF from cells activated by Con A was not found in the presence of OK-432. Thus, it is suggested that OK-432 might interfere with the induction of suppressor cells, but not with the expression of their activities.
D001688:Biological Products / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D015232:Dinoprostone; D006801:Humans; D066298:In Vitro Techniques; D010844:Picibanil / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D013491:Suppressor Factors, Immunologic / Q000378:metabolism; D013601:T-Lymphocytes / Q000145:classification / Q000187:drug effects; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology
D001688:Biological Products; D011458:Prostaglandins E; D013491:Suppressor Factors, Immunologic; D003208:Concanavalin A; D010844:Picibanil; D015232:Dinoprostone