Absorption studies of the H2-blocker nizatidine.
The absolute and relative bioavailability of nizatidine, an H2-blocker, was studied in healthy male volunteers. The absolute oral bioavailability, relative to that after intravenous administration, was 98% +/- 14%. The bioavailability of single and multiple oral doses of 150 mg nizatidine was unaffected by concurrent food ingestion; nizatidine may be administered either with or without food. The relative bioavailability of nizatidine was compared when given simultaneously with placebo or Gelusil, 30 minutes after propantheline, or 60 minutes before activated charcoal. Gelusil reduced the amount of nizatidine absorbed by about 10%, charcoal reduced it by about 30%, and propantheline did not affect it.
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D000536:Aluminum Hydroxide / Q000493:pharmacokinetics; D001682:Biological Availability; D002606:Charcoal / Q000493:pharmacokinetics; D004338:Drug Combinations / Q000493:pharmacokinetics; D004347:Drug Interactions; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007262:Infusions, Intravenous; D008276:Magnesium Hydroxide / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D016567:Nizatidine; D011413:Propantheline / Q000493:pharmacokinetics; D011897:Random Allocation; D012824:Silicic Acid / Q000493:pharmacokinetics; D013844:Thiazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013997:Time Factors
D004338:Drug Combinations; D006635:Histamine H2 Antagonists; D013844:Thiazoles; D011413:Propantheline; D012824:Silicic Acid; D002606:Charcoal; D000536:Aluminum Hydroxide; C036656:Gelusil; D008276:Magnesium Hydroxide; D016567:Nizatidine