Involvement of prostaglandin E-like material in the purgative action of rhein anthrone, the intraluminal active metabolite of sennosides A and B in mice.
Intracaecal administration of rhein anthrone, the intraluminally active metabolite of sennosides A and B, to mice quickly induced severe diarrhoea. Pretreatment with the prostaglandin (PG) biosynthesis inhibitor, indomethacin, and PGE2 antagonist, SC-19220, prevented the onset of diarrhoea induced by rhein anthrone, but the PGE2 antagonist polyphoretin phosphate (PPP) showed only a weak inhibitory effect. Rhein anthrone stimulated the production of PGE-like material only in the colon and its large intestinal propulsive activity was depressed by indomethacin and SC-19220, but not by PPP which suggests that the release of PGE-like material has some role in its purgative action.
D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology*; D001466:Barium Sulfate / Q000494:pharmacology; D002400:Cathartics; D003967:Diarrhea / Q000139:chemically induced; D012531:Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide / Q000494:pharmacology; D015232:Dinoprostone; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D011121:Polyphloretin Phosphate / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology / Q000502:physiology*; D012676:Senna Extract; D000081226:Sennosides
D000880:Anthraquinones; D002400:Cathartics; D011458:Prostaglandins E; D000081226:Sennosides; D012531:Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; D001466:Barium Sulfate; D012676:Senna Extract; D011121:Polyphloretin Phosphate; D015232:Dinoprostone; D007213:Indomethacin; C020491:rhein