Relations between blood flow and mucociliary activity in the rabbit maxillary sinus.
The effects of two sympathomimetic drugs on mucociliary activity and mucosal blood flow in the rabbit maxillary sinus were investigated by using a photo-electric technique (mucociliary activity) and laser Doppler flowmetry (blood flow). The responses produced were compared with effects of ligation of the external carotid artery. The alpha 1-agonist phenylpropanolamine (0.1-100 micrograms/kg) had no effect on the mucociliary activity, whereas the blood flow was reduced by 33.8 +/- 8.9% (mean +/- SE) when the dose was 100 micrograms/kg. The alpha 2-agonist xylometazoline (0.01-10.0 micrograms/kg) reduced mucociliary wave frequency by 21.6 +/- 4.6% (mean +/- SE) (maximum) for the dose 10 micrograms/kg. The blood flow was reduced by xylometazoline in the interval 1.0 to 10.0 micrograms/kg, with a maximum decrease of 65.8 +/- 2.6% (mean +/- SE) for the dose of 10 micrograms/kg. Ligature of the external carotid artery reduced blood flow by 76.0 +/- 4.6% (mean +/- SE), but did not significantly influence the mucociliary wave frequency. It is concluded that the decrease in mucociliary activity induced by alpha 2-adrenoceptor agonists is not due to a reduced blood flow.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D002342:Carotid Artery, External / Q000601:surgery; D005260:Female; D007093:Imidazoles / Q000494:pharmacology*; D007834:Lasers; D008026:Ligation; D008297:Male; D008443:Maxillary Sinus / Q000502:physiology*; D009079:Mucociliary Clearance / Q000187:drug effects*; D009092:Mucous Membrane / Q000502:physiology; D010665:Phenylpropanolamine / Q000494:pharmacology*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects*; D012212:Rheology
D000316:Adrenergic alpha-Agonists; D007093:Imidazoles; D010665:Phenylpropanolamine; C009695:xylometazoline