Influence of naloxone on H2-receptor blocker drugs effects in the "behavioral despair" test.
The influence of H2-receptor blockers (ranitidine and cimetidine) in a "behavioral despair" test in mice was studied. Both ranitidine and cimetidine shortened the immobility time at 20 mg X kg-1 and 30 mg X kg-1. Naloxone at 2 mg X kg-1 antagonized this reduction in immobility time.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D002927:Cimetidine / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology*; D011899:Ranitidine / Q000494:pharmacology; D011970:Receptors, Histamine H2 / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects
D000928:Antidepressive Agents; D006635:Histamine H2 Antagonists; D011970:Receptors, Histamine H2; D011957:Receptors, Opioid; D009270:Naloxone; D002927:Cimetidine; D011899:Ranitidine