[Effects of beta-carotene on genotoxic lesions in the liver under formation and action of carcinogenic N-nitrosodimethylamine].
beta-carotene pretreatment of rats decreased the methylation and formation of single-strand breaks in DNA and also decreased activity of alanine-aminotransferase, sorbitol dehydrogenase, gamma-glutamyl transpeptidase activities, caused by action of N-nitrosodimethylamine or synthesis of this carcinogen from precursors.
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D002338:Carotenoids / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism*; D004277:DNA, Single-Stranded / Q000096:biosynthesis / Q000378:metabolism; D004128:Dimethylnitrosamine; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008745:Methylation; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D004277:DNA, Single-Stranded; D002338:Carotenoids; D004247:DNA; D007064:L-Iditol 2-Dehydrogenase; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase; D004128:Dimethylnitrosamine
Vliianie beta-karotina na genotoksicheskie povrezhdeniia v pecheni pri obrazovanii i deĭstvii kantserogennogo N-nitrozodimetilamina.