Phenytoin infusion in severe pre-eclampsia.
Intravenous phenytoin sodium was given as a high-dose infusion (10 X 8-18 mg/kg) for anticonvulsive prophylaxis to 2 eclamptic patients and to 24 patients with moderate to severe pre-eclampsia. There were no major maternal or neonatal side-effects. Plasma phenytoin levels were within the therapeutic range (7-20 mg/l) at 30 min and 6 h after the infusion in all patients, and remained at a therapeutic level in 21 patients after 12 h. After a second dose of phenytoin in 19 patients, drug levels were within the therapeutic range at 24 h.
D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D010672:Phenytoin / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D011225:Pre-Eclampsia / Q000150:complications / Q000188:drug therapy*; D011247:Pregnancy; D012640:Seizures / Q000209:etiology / Q000517:prevention & control*
D010672:Phenytoin