Auranofin inhibits the active uptake of bile acid by rat ileum.
Auranofin in the mucosal fluid inhibited the active Na+-dependent absorption of taurocholic acid by everted sacs of rat ileum. It did not however, affect the passive uptake of taurocholic acid by sacs of mid-intestine. The inhibition by auranofin of active bile acid absorption could result from its previously demonstrated ability to inhibit Na+, K+-ATPase activity. A reduction in the reabsorption of bile acids by the ileum may contribute to the diarrhoea experienced by some patients taking auranofin.
D000818:Animals; D001310:Auranofin / Q000494:pharmacology*; D001647:Bile Acids and Salts / Q000378:metabolism*; D001834:Body Water / Q000378:metabolism; D003967:Diarrhea / Q000139:chemically induced; D007082:Ileum / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010539:Permeability; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D001647:Bile Acids and Salts; D001310:Auranofin; D000254:Sodium-Potassium-Exchanging ATPase