title: Qualitative and quantitative changes in normal aging and Alzheimer's disease.
abstract: Qualitative changes in normal aging and Alzheimer's disease (AD) are as important as quantitative changes. Although qualitative changes do not c-vary with quantitative differences in every respect, quantitative changes, nevertheless, often accurately reflect qualitative changes. Moreover, the complementary use of each provides a more detailed characterization of brain changes with aging and AD. The quantitative and qualitative changes of choline acetyltransferase, as well as somatostatin-containing neurons and dendrites, in human cortex are described as examples of this.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism / Q000473:pathology*; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D001921:Brain / Q000201:enzymology / Q000473:pathology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003712:Dendrites / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D009474:Neurons / Q000032:analysis / Q000473:pathology*; D013004:Somatostatin / Q000032:analysis
chemical_list: D013004:Somatostatin; D002795:Choline O-Acetyltransferase