Transient suppression of clonal hemopoiesis associated with pregnancy in a patient with a myeloproliferative disorder.
We have used restriction fragment length polymorphism analysis to study the clonal involvement of the blood cells in a woman with myeloproliferative disease, whose initially high platelet count (940,000/microliter) spontaneously decreased during a normal pregnancy but then returned rapidly to the same high level after delivery of her child. Analysis of her erythroid progenitors showed the presence of erythropoietin-independent progenitors before, during, and after her pregnancy, consistent with a diagnosis of myeloproliferative disease, and persistence of the abnormal clone throughout the period of study. Analysis of DNA from her blood granulocytes showed these to be polyclonal at mid-pregnancy, when her platelet count had decreased to normal values, in comparison to the monoclonal pattern exhibited by her blood granulocytes 3 mo postpartum, when her platelet count was again elevated. These results demonstrate a partial conversion to normal, polyclonal hemopoiesis during her pregnancy and suggest a previously unanticipated differential sensitivity of normal and neoplastic hemopoietic cells to physiological changes associated with this state.
D000328:Adult; D001792:Blood Platelets; D002452:Cell Count; D002999:Clone Cells; D004247:DNA / Q000032:analysis; D005260:Female; D005347:Fibroblasts; D006098:Granulocytes; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells; D006801:Humans; D009196:Myeloproliferative Disorders / Q000097:blood / Q000235:genetics / Q000503:physiopathology*; D014411:Neoplastic Stem Cells; D009693:Nucleic Acid Hybridization; D010976:Platelet Count; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000503:physiopathology*
D004247:DNA