Effect of food deprivation on opioid receptor binding in the brain of lean and fatty Zucker rats.
The effect of food deprivation on opioid receptor binding was studied in 6 brain regions of lean and fatty Zucker rats; using [3H]dynorphin A. There was no significant difference between lean and fatty rats fed ad libitum in binding parameters for any regions studied. Food deprivation increased Bmax and/or Kd for cortex, midbrain and striatum of lean rats, and the former two regions of fatty rats. These results suggest that food deprivation may influence opioid receptor binding in lean and fatty Zucker rats.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004399:Dynorphins / Q000378:metabolism*; D005508:Food Deprivation / Q000502:physiology*; D007700:Kinetics; D008297:Male; D009765:Obesity / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D051381:Rats; D011924:Rats, Zucker
D010446:Peptide Fragments; D004399:Dynorphins; C026770:dynorphin (1-8)