Immunohistochemical distribution of cholecystokinin, dynorphin A and Met-enkephalin neurons in sheep hypothalamus.
The distribution of cholecystokinin (CCK)-, Met-enkephalin (M-ENK)- and dynorphin (DYN)-like immunoreactive perikarya were examined in the sheep hypothalamus using the peroxidase-anti-peroxidase technique. CCK- and DYN-containing neurons were found primarily in the suprachiasmatic nucleus (SCH) and supraoptic nucleus (SO). No CCK- or DYN-containing neurons were found in the paraventricular nucleus (PVN). M-ENK-containing neurons were found mainly in the PVN of the hypothalamus. In addition, M-ENK neurons were found in the dorsomedial (DMH), lateral (LH), anterior (AH) and periventricular hypothalamic areas. The distribution of these neuropeptides may provide a basis for understanding differences in responsiveness to centrally administered peptides.
D000818:Animals; D002766:Cholecystokinin / Q000032:analysis* / Q000276:immunology; D004399:Dynorphins / Q000032:analysis* / Q000276:immunology; D004744:Enkephalin, Methionine / Q000032:analysis* / Q000276:immunology; D007031:Hypothalamus / Q000033:anatomy & histology / Q000166:cytology*; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D009474:Neurons / Q000166:cytology*; D012756:Sheep
D004744:Enkephalin, Methionine; D004399:Dynorphins; D002766:Cholecystokinin