Active suppression of interleukin 2 secretion in mice infected with Trypanosoma brucei AnTat 1.1.E.
Impairment of T cell proliferation in mice infected with the pleomorphic Trypanosoma brucei AnTat 1.1 E clone was found not to be related to a depletion of T cells or to an absence of functional accessory cells, but rather to an active suppression of interleukin 2 (IL-2) production. Lymph node cells derived from infected mice failed to produce IL-2 following Con A stimulation, whereas an exogenous supply of recombinant IL-2 could restore the impairment of the mitogen (Con A)-induced proliferative responses. Furthermore, lymph node cells derived from infected mice suppressed both secondary T-cell proliferative responses and IL-2 secretion, indicating that the trypanosome-induced suppression is mediated by a suppressive cell which interferes at the level of IL-2 secretion.
D000818:Animals; D002478:Cells, Cultured; D007165:Immunosuppression Therapy; D007376:Interleukin-2 / Q000096:biosynthesis / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology*; D014346:Trypanosoma brucei brucei / Q000276:immunology; D014353:Trypanosomiasis, African / Q000276:immunology* / Q000662:veterinary*
D007376:Interleukin-2