The fractional catabolic rate of low density lipoprotein in normal individuals is influenced by variation in the apolipoprotein B gene: a preliminary study.
In a random sample of 22 normolipidaemic male Caucasian individuals, 35-49 years old, homozygosity for the X2 allele (cutting site) of the XbaI RFLP of the apo B gene was associated with higher mean total cholesterol and LDL-cholesterol concentration. These individuals also had significantly lower LDL fractional catabolic rate (P less than 0.03) and a lower degradation of LDL by mononuclear cells in vitro. We propose that the XbaI polymorphism is associated with amino acid changes in the apo B protein which influences LDL binding to the LDL-receptor. This modulates catabolism of this lipoprotein and so contributes to variability of plasma cholesterol levels.
D000328:Adult; D001055:Apolipoproteins B / Q000235:genetics*; D005796:Genes; D014644:Genetic Variation; D006720:Homozygote; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D011973:Receptors, LDL / Q000235:genetics
D001055:Apolipoproteins B; D008077:Lipoproteins, LDL; D011973:Receptors, LDL