Interactions of human fibroblast interferon with chemotherapeutic agents and radiation against human gliomas in nude mice.
The growth inhibitory effects of the combination of beta-interferon (beta-IFN) and conventional anticancer drugs such as adriamycin (ADM) and ACNU were evaluated in nude mice receiving subcutaneous transplants of human glioblastoma. Next, the anticancer and radiation sensitizing effects of beta-IFN on human glioblastoma was also evaluated in nude mice model. After three weeks of combined treatment, tumour reduction rates (treated/control values) were evaluated by the Battelle's method. In conclusion, the growth inhibitory effect of IFN was most enhanced when IFN was administered following radiotherapy. Furthermore, the combined effect was enhanced in proportion to the dose of radiation.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D005910:Glioma / Q000532:radiotherapy / Q000628:therapy*; D007370:Interferon Type I / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D015376:Nimustine; D009607:Nitrosourea Compounds / Q000627:therapeutic use
D000970:Antineoplastic Agents; D007370:Interferon Type I; D009607:Nitrosourea Compounds; D015376:Nimustine; D004317:Doxorubicin