Somatostatin-induced inhibition of lipolysis: in vitro studies.
Incubation of epididymal fat tissue slices with somatostatin (SS) led to the inhibition of epinephrine-induced release of free fatty acids (FFA) and glycerol in a dose-dependent manner. The SS administration did not suppress the lipolysis evoked by dibutyryl cAMP. The experimental findings indicate that SS exerts an inhibition of catecholamines-induced lipolysis at the level of adipocytes although the mechanism of action requires further investigations.
D000818:Animals; D003994:Bucladesine / Q000037:antagonists & inhibitors; D004837:Epinephrine / Q000037:antagonists & inhibitors; D005230:Fatty Acids, Nonesterified / Q000096:biosynthesis; D005990:Glycerol / Q000096:biosynthesis; D066298:In Vitro Techniques; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology*
D005230:Fatty Acids, Nonesterified; D013004:Somatostatin; D003994:Bucladesine; D005990:Glycerol; D004837:Epinephrine