Correlation of type A behaviour with adrenergic receptor density: implications for coronary artery disease pathogenesis.
In 17 healthy young men who had a parent with documented early coronary disease, ratings of type A behaviour correlated with upregulated lymphocyte beta 2 receptor density and inversely with the ratio of platelet alpha 2 to lymphocyte beta 2 receptor density ratio. This indicates a correlation of type A behaviour with receptor-based determinations of increased peripheral alpha-adrenergic balance, consistent with increased coronary arterial vasoconstriction, perhaps leading to coronary artery disease.
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000235:genetics; D001792:Blood Platelets / Q000032:analysis; D003327:Coronary Disease / Q000209:etiology* / Q000235:genetics; D000242:Cyclic AMP / Q000097:blood; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D007545:Isoproterenol; D008214:Lymphocytes / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics; D011942:Receptors, Adrenergic, alpha / Q000032:analysis*; D011943:Receptors, Adrenergic, beta / Q000032:analysis*; D012307:Risk Factors; D014434:Type A Personality
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP; D007545:Isoproterenol