title: Fragile sites and high-resolution chromosome studies in multiple endocrine neoplasia type 2A.
abstract: Affected individuals from four kindreds with multiple endocrine neoplasia type 2A syndrome (MEN-2A), were studied for the possible existence of a specific fragile site that might be associated with the MEN-2A gene. The chromosomes were also examined with high-resolution banding with particular emphasis on those chromosomes (#1, 10, 20, and 22) that have been implicated by previous studies from several laboratories as being associated with this disease. There was no evidence for a unique fragile site or a unique high-resolution banding pattern in subjects with MEN-2A. These findings, in combination with all previous cytogenetic studies, indicate that it is unlikely that current techniques will be useful in developing a simple cytogenetic test for this disease.
mesh_terms: D016590:Aphidicolin; D002871:Chromosome Banding; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D004224:Diterpenes / Q000494:pharmacology; D006801:Humans; D007621:Karyotyping; D009377:Multiple Endocrine Neoplasia / Q000235:genetics*
chemical_list: D004224:Diterpenes; D016590:Aphidicolin