Beta-globin gene polymorphism in Saudis--triple Hpa I fragments.
In an attempt to investigate beta-globin gene polymorphism in the Saudi population, DNA samples were analysed using restriction endonucleases, Mst II and Hpa I. Both beta A and beta S genes showed extensive polymorphism and were found to be linked to 13.0 kb, 7.6 kb, 7.0 kb, and 5.6 kb Hpa I fragments. Three DNA samples out of a total of 436 analysed, had beta-globin gene linked to three Hpa I fragments of the sizes 13.0 kb, 7.6 kb, and 5.6 kb. In this paper we present our findings and discuss the possibility of multiple beta-globin loci.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood / Q000235:genetics; D003434:Crossing Over, Genetic; D004247:DNA / Q000032:analysis; D005796:Genes; D008040:Genetic Linkage; D005914:Globins / Q000235:genetics*; D006441:Hemoglobin A / Q000032:analysis; D006451:Hemoglobin, Sickle / Q000235:genetics; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012529:Saudi Arabia
D006451:Hemoglobin, Sickle; D005914:Globins; D004247:DNA; D006441:Hemoglobin A