title: Phencyclidine depresses transmitter release at the neuromuscular synapse of the locust.
abstract: The presynaptic effects of phencyclidine (PCP) were studied in the locust extensor tibiae muscle. The neurally evoked transmitter release is diminished in the presence of 5 x 10(-6) to 5 x 10(-5) M PCP. This is indicated (1) by an increased coefficient of variation of the excitatory junction potentials; (2) by an increased rate of failures (a) with nerve stimulation in low [Ca2+]saline and (b) with focal extracellular stimulation in normal [Ca2+]saline. The rate of spontaneous transmitter release is not affected.
mesh_terms: D000818:Animals; D004594:Electrophysiology; D005260:Female; D006110:Grasshoppers; D009469:Neuromuscular Junction / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009994:Osmolar Concentration; D010622:Phencyclidine / Q000494:pharmacology*; D013569:Synapses / Q000378:metabolism*; D013997:Time Factors
chemical_list: D018377:Neurotransmitter Agents; D010622:Phencyclidine