title: Influence of age on intrinsic clearance of bupivacaine and its reduction by cimetidine in elderly male rats.
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D002045:Bupivacaine / Q000378:metabolism*; D002927:Cimetidine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D002927:Cimetidine; D002045:Bupivacaine