Association of human hepatocellular membrane fusions with non-A, non-B hepatitis.
Liver biopsies from patients with alcoholic hepatitis, chemical hepatitis, or viral hepatitis types A, B, or non-A, non-B were examined by electron microscopy. Circular, fused, cytoplasmic membranes were observed in hepatocytes of 17% of patients with hepatitis type B and 92% of patients with hepatitis type non-A, non-B. The membrane alterations were not observed in hepatocytes of patients with the other types of hepatitis. The greater frequency of altered cytoplasmic membranes in hepatocytes of patients with non-A, non-B hepatitis was shown to be statistically significant (p less than 0.05) when compared to that in patients with viral hepatitis type B.
D000818:Animals; D001706:Biopsy; D002462:Cell Membrane / Q000648:ultrastructure; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology; D006505:Hepatitis / Q000473:pathology*; D006506:Hepatitis A / Q000473:pathology; D006509:Hepatitis B / Q000473:pathology; D006526:Hepatitis C / Q000473:pathology*; D006519:Hepatitis, Alcoholic / Q000473:pathology; D006525:Hepatitis, Viral, Human / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000648:ultrastructure*; D008854:Microscopy, Electron; D002679:Pan troglodytes