title: Effect of adrenergic drugs on the isolated colon of Rhesus cynomolgus.
abstract: The effects of adrenaline, noradrenaline, isoprenaline and dopamine were studied on the longitudinal muscle of the ascending and descending colon of the rhesus monkey. All these drugs induced a relaxation of the preparation, dopamine being the less active agonist. The responses seem to be the result of beta 2-adrenoceptor stimulation since their inhibition by practolol (beta 1) is weaker than their inhibition by propranolol (beta 1 and beta 2 dopaminergic). There is no evidence for the presence of dopaminergic receptors in this preparation.
mesh_terms: D000818:Animals; D003106:Colon / Q000187:drug effects; D066298:In Vitro Techniques; D008253:Macaca mulatta; D009130:Muscle, Smooth / Q000187:drug effects*; D013566:Sympathomimetics / Q000494:pharmacology*
chemical_list: D013566:Sympathomimetics