The IL-4 gene maps to chromosome 11, near the gene encoding IL-3.
IL-4/B cell stimulatory factor 1 (IL-4) is a potent mediator of the growth and differentiation of cells of most hemopoietic lineages. IL-4 is one of a number of lymphokines produced by T cells after activation with Ag or mitogen. In order to map the chromosomal location of the IL-4 gene, Chinese hamster-mouse somatic cell hybrids were used in Southern blot analyses with an IL-4 cDNA probe. These results suggested that the IL-4 gene was located on chromosome 11. In contrast, the gene encoding IL-2 was localized to either chromosome 1 or 3. The identification of a strain-specific Bgl II restriction enzyme polymorphism in the IL-4 gene was used to map the IL-4 gene to a position on mouse chromosome 11 within 1 centimorgan of the gene encoding IL-3.
D000818:Animals; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D005796:Genes; D008040:Genetic Linkage; D005819:Genetic Markers; D006822:Hybrid Cells / Q000032:analysis; D007377:Interleukin-3 / Q000235:genetics*; D015847:Interleukin-4; D007378:Interleukins / Q000235:genetics*; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D012150:Polymorphism, Restriction Fragment Length
D005819:Genetic Markers; D007377:Interleukin-3; D007378:Interleukins; D015847:Interleukin-4