title: Surface proteins of Bordetella pertussis.
abstract: Bordetella pertussis cells express multiple virulence-associated surface proteins, including adenylate cyclase, agglutinogens 2 and 3, filamentous hemagglutinin, pertussis toxin, and outer-membrane protein (Omp) 30/32 and Omp91. Surface proteins that are not virulence-associated include three peptidoglycan-associated Omps of apparent molecular weights 40,000, 25,000, and 18,000. Omp40 is an anion-selective porin and is the most abundant surface protein of virulent and avirulent cells. Three independent approaches--immunomicroscopy, surface radioiodination, and isolation of Triton X-100-insoluble envelope proteins--suggest that the Triton-insoluble fraction of the B. pertussis cell envelope is the outer membrane. Agglutinogens 2 and 3 and filamentous hemagglutinin lie outside the outer membrane, the first two as fimbriae and the last as a microcapsule. Adenylate cyclase and pertussis toxin are present in the outer membrane but may be present transiently or present in small amounts.
mesh_terms: D001426:Bacterial Proteins / Q000032:analysis*; D001886:Bordetella pertussis / Q000032:analysis* / Q000472:pathogenicity / Q000648:ultrastructure; D002462:Cell Membrane / Q000032:analysis; D008565:Membrane Proteins / Q000032:analysis*; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins