Selective incorporation of n-3 and n-6 fatty acids in essential fatty acid deficient rats in response to short-term oil feeding.
Essential fatty acid deficient male Sprague Dawley rats were fed for 7 days a fat-free semi-synthetic diet supplemented with 10% by weight of different oil supplements. The oil supplement was a mixture of olive, safflower and linseed oils prepared at different proportions so the dietary n-9/n-6/n-3 ratios were approximate 2/1/1, 1/2/1, 1/1/2, and 1/1/1. The fatty acid compositions of plasma and liver lipids were then examined. Our results show polyunsaturated n-6 and n-3 fatty acids were selectively incorporated into plasma and liver phospholipids, and also into plasma cholesteryl esters. A preferential incorporation of n-6 over n-3 fatty acids into plasma cholesteryl esters and phospholipids was also observed.
D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage*; D005228:Fatty Acids, Essential / Q000172:deficiency*; D008041:Linoleic Acids / Q000493:pharmacokinetics*; D008042:Linolenic Acids / Q000493:pharmacokinetics*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000493:pharmacokinetics; D010743:Phospholipids / Q000378:metabolism; D010938:Plant Oils / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism; D017962:alpha-Linolenic Acid
D004041:Dietary Fats; D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D008042:Linolenic Acids; D009829:Oleic Acids; D010743:Phospholipids; D010938:Plant Oils; D014280:Triglycerides; D017962:alpha-Linolenic Acid; D019301:Oleic Acid