Interaction of vitamin E and its model compounds with unsaturated fatty acids in homogeneous solution.
Either alpha-tocopherol (vitamin E) or one of its model compounds having side chains of different length at the 2-position of alpha-tocopherol, forms complexes with an unsaturated fatty acid in methanol. For complex formation, the isoprenoid side chain and hydroxy group of alpha-tocopherol are unessential and, rather, the methyl groups attached to the aromatic ring of the chromanol moiety seems to be responsible. For better interaction, more than three methylene-interrupted Z double bonds of a fatty acid are necessary. These findings are incompatible with the hypothesis of Diplock and Lucy on the interaction of vitamin E with each polyunsaturated fatty acid.
D016718:Arachidonic Acid; D001095:Arachidonic Acids; D055598:Chemical Phenomena; D002621:Chemistry; D005231:Fatty Acids, Unsaturated; D008042:Linolenic Acids; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012996:Solutions; D013050:Spectrometry, Fluorescence; D014810:Vitamin E; D017962:alpha-Linolenic Acid
D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D008042:Linolenic Acids; D012996:Solutions; D017962:alpha-Linolenic Acid; D014810:Vitamin E; D016718:Arachidonic Acid