(1S,2R)-5-methoxy-1-methyl-2-(n-propylamino)tetralin ([+]-AJ-76) elevates transmitter synthesis in dopaminergic neurons surviving a partial nigrostriatal lesion.
(+)-AJ-76 is a novel compound with a spectrum of actions suggesting that it is a selective antagonist of dopamine (DA) autoreceptors. In animals with partial lesions of the dopaminergic nigrostriatal system, in which DA synthesis of surviving neurons was elevated, (+)-AJ-76 further increased DA synthesis above levels produced by the lesion alone. This finding suggests that (+)-AJ-76 might be of value in the treatment of Parkinson's disease.
D000818:Animals; D003342:Corpus Striatum / Q000502:physiology; D004298:Dopamine; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism; D013378:Substantia Nigra / Q000502:physiology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D009281:Naphthalenes; D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine; D013764:Tetrahydronaphthalenes; C051171:5-methoxy-1-methyl-2-(n-propylamino)tetralin; D004298:Dopamine