Primary central nervous system lymphomas in patients with AIDS.
Primary central nervous system non-Hodgkin's lymphomas are observed in approximately 1.9% of all patients with acquired immunodeficiency syndrome (AIDS). The yearly incidence of AIDS-associated tumors has surpassed the yearly incidence from all other causes and could become as frequent as low-grade astrocytomas by 1991. Patients' signs, symptoms, and radiographic studies are not specific for this lesion; brain biopsy usually is necessary to make a definitive diagnosis. Most tumors are high-grade lymphomas and are pathologically similar to the primary central nervous system lymphomas observed before the AIDS epidemic. AIDS-associated tumors respond readily to radiation therapy. However, patient survival remains limited owing to other manifestations of the syndrome.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology; D001932:Brain Neoplasms / Q000150:complications* / Q000209:etiology / Q000276:immunology; D002051:Burkitt Lymphoma / Q000150:complications; D006800:Deltaretrovirus Infections / Q000150:complications; D004854:Herpesvirus 4, Human; D006801:Humans; D007108:Immune Tolerance; D008223:Lymphoma / Q000150:complications* / Q000209:etiology / Q000276:immunology