title: Pharmacokinetics of single and multiple doses of flusoxolol (Ro 31-1411) in healthy subjects.
abstract: Flusoxolol (Ro 31-1411) is the pharmacologically active optical isomer of Ro 31-1118, a potent cardioselective beta-adrenoceptor antagonist with partial agonist activity. It was given to 6 healthy volunteers in a single dose, 40 mg, and then in multiple doses, 40 mg daily for 8 days. Plasma concentration data were best described by a linear two-compartment pharmacokinetic model with first order absorption, and the results confirmed linear kinetics. Pharmacokinetic data for flusoxolol were comparable to those for the racemate Ro 31-1118.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D000328:Adult; D006801:Humans; D007700:Kinetics; D008297:Male; D050198:Phenoxypropanolamines; D005082:Physical Exertion; D011412:Propanolamines / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
chemical_list: D000319:Adrenergic beta-Antagonists; D050198:Phenoxypropanolamines; D011412:Propanolamines; C045426:flusoxolol