[Pharmacoethological analysis of the effects of thyroliberin and melanostatin in a model of anxious-defensive behavior in mice].
Psychotropic properties of thyroliberin and melanostatin were studied on the model of timid-defensive behaviour of mice. Oligopeptides increased defensive behaviour and timidity, and decreased intraspecies sociability. GABA deficiency and dopaminergic system blockade increased timid-defensive behaviour of mice. Mobilizing activity of peptides on the agonistic behaviour (aggression and defense) may be explained by their anxiogenic properties.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001007:Anxiety / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D009075:MSH Release-Inhibiting Hormone / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011954:Receptors, Dopamine / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D013997:Time Factors
D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D013973:Thyrotropin-Releasing Hormone; D009075:MSH Release-Inhibiting Hormone
Farmakoétologicheskiĭ analiz éffektov tiroliberina i melanostatina na modeli trevozhno-zashchitnogo povedeniia mysheĭ.