Synergistic activity of sodium cromoglycate and beta 2-stimulants in rat lung anaphylaxis.
Using a model of passive anaphylactic bronchoconstriction in the rat, the combined inhibitory effects of sodium cromoglycate and the beta 2-adrenoceptor agonists fenoterol and salbutamol were shown to be synergistic. Synergism was most evident in animals strongly sensitised with relatively high levels of IgE antibodies, in which the individual drugs showed reduced potency.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000707:Anaphylaxis / Q000503:physiopathology / Q000517:prevention & control*; D000818:Animals; D001980:Bronchi / Q000503:physiopathology; D004205:Cromolyn Sodium / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D005280:Fenoterol / Q000494:pharmacology; D008171:Lung Diseases / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains
D000318:Adrenergic beta-Agonists; D005280:Fenoterol; D004205:Cromolyn Sodium