title: Effects of fasting and oral premedication on the pH and volume of gastric aspirate in children.
abstract: The pH and volume of gastric aspirate were measured immediately after the induction of anaesthesia in 224 healthy children to determine the effects of decreasing the period of fasting and of giving oral premedicants before anaesthesia. Fasting for less than 4 h was found to increase the volume of gastric aspirate and the risk of developing pulmonary aspiration syndrome. Trimeprazine syrup was found to increase the pH of the gastric contents, and decrease the likelihood of the pulmonary aspiration syndrome. There was a significant increase in gastric volume in patients premedicated with temazepam elixir which did not occur in patients given temazepam capsules. These results support the custom of fasting patients for at least 4 h before anaesthesia and indicate that oral premedicants and their vehicles can have significant effects on the stomach.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D005215:Fasting; D005766:Gastrointestinal Contents; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D011229:Preanesthetic Medication; D012306:Risk; D013693:Temazepam / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D013693:Temazepam