title: Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease.
abstract: Serum samples taken on admission from 79 patients with meningococcal meningitis, septicaemia, or both, were examined in a highly sensitive bioassay for tumour necrosis factor (TNF). TNF was detected in samples from 10 of 11 patients who died but from only 8 of 68 survivors. All 5 patients with serum TNF levels over 440 units/ml (corresponding to 0.1 ng/ml recombinant TNF) died.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007223:Infant; D008297:Male; D008585:Meningitis, Meningococcal / Q000097:blood / Q000401:mortality; D008589:Meningococcal Infections / Q000097:blood / Q000401:mortality*; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha
chemical_list: D006023:Glycoproteins; D014409:Tumor Necrosis Factor-alpha