Involvement of the sympathetic nervous system in lipolytic activity in brown adipose tissue of cold acclimated rats.
In cold acclimated rats, in vitro, NE led to a significant increase in release of FFA and glycerol in denervated IBAT. In vivo, study of arteriovenous differences showed that the denervated BAT loses its full capacity to utilize FFA and glycerol released by NE. After denervation an increase of blood flow in Sulzer's vein was observed. This effect appeared immediately after intervention whereas the effect on fat metabolism appeared later. In cold acclimated rats, the sympathetic nervous system appears to be an important regulator of fatty acid metabolism in BAT.
D000064:Acclimatization; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D000818:Animals; D001835:Body Weight; D003080:Cold Temperature; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D009929:Organ Size; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology*
D009638:Norepinephrine