A preferred region for integration of Friend murine leukemia virus in hematopoietic neoplasms is closely linked to the Int-2 oncogene.
Gene mapping experiments show that Fis-1, a preferred integration region for Friend murine leukemia virus in hematopoietic neoplasms, is extremely closely linked to Int-2, a preferred integration region for mouse mammary tumor virus in mammary carcinomas. Studies at the RNA and DNA level prove that these loci are distinct.
D000818:Animals; D002472:Cell Transformation, Viral; D002874:Chromosome Mapping; D005622:Friend murine leukemia virus / Q000235:genetics*; D008040:Genetic Linkage; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics*; D007942:Leukemia, Experimental / Q000235:genetics*; D051379:Mice / Q000235:genetics*; D009857:Oncogenes; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic