Ultrastructural localization of calcitonin and somatostatin in C cells of rabbit thyroid.
C cells of rabbit thyroid exhibit significant differences in morphology, namely a variable nuclear structure and differences in size and osmophility of secretory granules. An examination of serial sections of these cells was made, using the immunocytochemical PAP or protein A-gold procedures. All C cells, irrespective of their morphology, were found to store both calcitonin and somatostatin in all secretory granules. The physiological role of somatostatin in calcitonin secretion by C cells is discussed.
D000818:Animals; D002116:Calcitonin / Q000032:analysis*; D005260:Female; D006801:Humans; D007118:Immunoassay; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D011817:Rabbits; D013004:Somatostatin / Q000032:analysis*; D013961:Thyroid Gland / Q000166:cytology* / Q000648:ultrastructure
D013004:Somatostatin; D002116:Calcitonin