An abnormal pattern of amniotic fluid microvillar enzymes signalling fetal cystic fibrosis.
We have observed seven pregnancies at risk for fetal cystic fibrosis where second-trimester amniotic fluid microvillar enzyme activities presented an unusual pattern. Low gamma-glutamyltranspeptidase and borderline alpha-glucosidase values were associated with normal aminopeptidase M and intestinal alkaline phosphatase values. All seven pregnancies went to term; five of the seven infants were affected with cystic fibrosis.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000626:Aminopeptidases / Q000378:metabolism; D000653:Amniotic Fluid / Q000201:enzymology*; D018826:CD13 Antigens; D003550:Cystic Fibrosis / Q000175:diagnosis*; D005260:Female; D005865:Gestational Age; D006801:Humans; D008470:Meconium / Q000201:enzymology; D011247:Pregnancy; D011296:Prenatal Diagnosis; D000520:alpha-Glucosidases / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D000520:alpha-Glucosidases; D000626:Aminopeptidases; D018826:CD13 Antigens