Sensitivity of antinociceptive tests to opioid agonists and partial agonists.
There is considerable variation in the potency of opioids across different animal models of antinociceptive activity. In the less sensitive tests the partial agonist analgesics behave as antagonists. The activity of opioids in antinociceptive tests appears to be dependent on both the intensity of the noxious stimulus and the intrinsic activity of the drug.
D000698:Analgesia; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D008722:Methods; D051379:Mice; D010146:Pain / Q000503:physiopathology*
D000701:Analgesics, Opioid