Effect on fertility in rats of epididymal administration of indomethacin.
Rods 2 mm in diameter and 8 mm long containing 25% or 50% indomethacin were implanted adjacent to each epididymis in rats of proven fertility. During the first 4 weeks after operation, fertility was reduced, but returned to normal at 5 to 10 weeks. The time of onset and duration of the effect were variable. Libido, ejaculation, and sperm motility were unimpaired. Drug-free Silastic rods had no effect on fertility. The results provide indirect evidence that prostaglandins have a functional role in the reproductive system of the male rat.
D000818:Animals; D004343:Drug Implants; D004542:Ejaculation / Q000187:drug effects; D004822:Epididymis / Q000187:drug effects*; D005298:Fertility / Q000187:drug effects*; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007989:Libido / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013081:Sperm Motility / Q000187:drug effects
D004343:Drug Implants; D007213:Indomethacin