title: Mapping of the mouse fibronectin gene (Fn-1) to chromosome 1: conservation of the Idh-1-Cryg-Fn-1 synteny group in mammals.
abstract: Restriction fragment length polymorphisms (RFLPs) were observed in BamHI-digested mouse DNA probed with a cDNA for human fibronectin. Analysis of the inheritance of fibronectin RFLPs in AKXD and SWXJ recombinant inbred strains of mice mapped the locus, Fn-1, to the midregion of mouse chromosome 1 about 4 cM distal from the loci encoding gamma-crystallins (Cryg). Loci homologous to genes in the centromeric third of mouse chromosome 1 are also syntenic in rats, humans, and cattle and may, therefore, mark a large conserved chromosomal segment of the mammalian genome.
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002874:Chromosome Mapping; D003459:Crystallins / Q000235:genetics; D005353:Fibronectins / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D008322:Mammals / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D003459:Crystallins; D005353:Fibronectins; D007521:Isocitrate Dehydrogenase