title: Dopamine modulates evoked transmission at cholinergic synapses formed by rat retinal neurons with muscle cells.
abstract: The purpose of this study was to investigate the effect of dopamine on synaptic transmission mediated by cholinergic neurons derived from the rat retina. We used a cell culture system that permitted the physiological monitoring of acetylcholine released at synapses formed between retinal neurons and striated muscle cells. Dopamine was found to facilitate evoked transmission by a mechanism mediated by D1 dopamine receptors. The results support the hypothesis that dopamine may have a modulatory role in information processing by the mammalian retina.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004298:Dopamine / Q000494:pharmacology*; D018492:Dopamine Antagonists; D005071:Evoked Potentials / Q000187:drug effects; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D009132:Muscles / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000145:classification* / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012160:Retina / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D013569:Synapses / Q000145:classification* / Q000187:drug effects / Q000502:physiology
chemical_list: D018492:Dopamine Antagonists; D005971:Glutamates; D018698:Glutamic Acid; D004298:Dopamine