title: Comparison of sodium hypochlorite and sodium dichloroisocyanurate disinfectants: neutralization by serum.
abstract: A comparison has been made of the activity against Pseudomonas aeruginosa of sodium hypochlorite (NaOCl) and sodium dichloroisocyanurate (NaDCC) solutions containing 0-40% and 0-70% horse serum respectively. The degree of inactivation of NaOCl and of NaDCC solutions by different concentrations of horse serum is expressed in terms of a neutralization coefficient, which demonstrates that NaDCC solutions are less prone to inactivation by serum than are NaOCl solutions, the disparity diverging as serum concentration is increased. In 30% serum an NaDCC solution containing 4000 ppm of available chlorine exhibited similar bactericidal activity to an NaOCl solution containing 17,000 ppm available chlorine.
mesh_terms: D001769:Blood / Q000378:metabolism*; D004202:Disinfectants / Q000378:metabolism / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012973:Sodium Hypochlorite / Q000378:metabolism / Q000494:pharmacology*; D014227:Triazines / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D004202:Disinfectants; D014227:Triazines; D012973:Sodium Hypochlorite; C011765:troclosene