title: Recommendations for the statistical analysis of Chernoff/Kavlock test data.
abstract: The statistical analyses of the data related to the teratogenic testing of 60 compounds utilizing the Chernoff/Kavlock test are the basis of this paper. The hypotheses chosen to be tested and the statistical tests utilized to test those hypotheses are discussed. The topics explored are the use of comparisonwise error rate versus experimentwise error rate, the use of nonparametric tests versus more "conventional" parametric tests and the use of "historical data" in assessing and interpreting group difference.
mesh_terms: D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005865:Gestational Age; D011247:Pregnancy; D011897:Random Allocation; D051381:Rats; D012107:Research Design; D013223:Statistics as Topic; D013723:Teratogens / Q000633:toxicity*
chemical_list: D013723:Teratogens