Failure of uterine withdrawal bleeding following exogenous estrogen and progestin administration.
A woman who showed no secretory effect on repeated endometrial samplings, in the absence of Asherman's syndrome on hysteroscopy, conceived on clomiphene administration. The possibility of uterine progesterone receptor decreases in number or affinity as a cause of improper histologic response to endogenous hormone production is discussed.
D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy*; D002996:Clomiphene / Q000627:therapeutic use*; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D011247:Pregnancy; D011374:Progesterone / Q000627:therapeutic use*; D011980:Receptors, Progesterone / Q000378:metabolism; D014592:Uterine Hemorrhage / Q000139:chemically induced*; D014599:Uterus / Q000378:metabolism
D004966:Estrogens, Conjugated (USP); D011980:Receptors, Progesterone; D002996:Clomiphene; D011374:Progesterone