title: Scrapie: a virus-induced amyloidosis of the brain.
abstract: We have studied the pathogenesis of scrapie in hamsters, in particular the increase of infectivity and the formation of scrapie-associated fibrils in relation to clinical disease. The results of such studies after intraperitoneal or intracerebral infection are consistent with the idea that transmissible spongiform encephalopathies are a type of virus-induced, brain-specific amyloidosis. Therefore, an appropriate name for the class of viruses that cause these diseases might be amyloid-inducing viruses.
mesh_terms: D000686:Amyloidosis / Q000209:etiology* / Q000378:metabolism / Q000382:microbiology; D000818:Animals; D001921:Brain / Q000378:metabolism; D001927:Brain Diseases / Q000209:etiology* / Q000378:metabolism / Q000382:microbiology; D007700:Kinetics; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D018622:PrP 27-30 Protein; D011328:Prions / Q000472:pathogenicity; D012608:Scrapie / Q000378:metabolism / Q000382:microbiology; D013997:Time Factors; D014779:Virus Replication
chemical_list: D009419:Nerve Tissue Proteins; D011328:Prions; D018622:PrP 27-30 Protein