The influence of antihistamine compounds on the oral intake of different addictive drugs.
The influence of two antihistamines on the oral intake of various drugs with addictive potency was investigated in rats. Under the chosen conditions neither tripelennamine nor diphenhydramine have reinforcing properties. The reinforcing potency of addictive drugs is not augmented by the both substances. On the contrary, in some cases they led to a decrease in oral intake of the drug solutions offered.
D000661:Amphetamine; D000818:Animals; D001562:Benzimidazoles; D004155:Diphenhydramine / Q000494:pharmacology; D000431:Ethanol; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D013287:Illicit Drugs; D008702:Methaqualone; D010423:Pentazocine; D051381:Rats; D012054:Reinforcement, Psychology; D019966:Substance-Related Disorders; D014309:Tripelennamine / Q000494:pharmacology
D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D013287:Illicit Drugs; D014309:Tripelennamine; D000431:Ethanol; D008702:Methaqualone; D004155:Diphenhydramine; D000661:Amphetamine; D010423:Pentazocine