title: Excitable membranes--object for evaluating the effect of heavy metal pollution.
abstract: In acute experiments the interaction of heavy metals (CdCl2 and HgCl2) with neurotransmitters (ACh and 5HT) was studied on the excitable membrane of the identified neurons in the central nervous system of Helix pomatia L. (Gastropoda, Mollusca). It was shown that cadmium and mercury ions exert different influence on both resting and action potentials as well as on the responsiveness of the neural membranes to ACh and 5HT. The selective blocking effect of cadmium and mercury ions can be interpreted on the basis of specificity of postsynaptic receptor structures responsible for the transmitter action and of ion-channels involved in the excitatory processes. The heavy metal effect was not uniform for the different types of neurons, suggesting that pollutants can modify various functions to a different degree. The results show that testing on nerve cell membranes can serve as a useful method and model in investigating the effect of sublethal environmental contamination, as they may cause a profound modulation on the elements of the neural circuitry responsible for the regulation of the animal's behavior.
mesh_terms: D000200:Action Potentials; D000818:Animals; D002104:Cadmium / Q000032:analysis / Q000633:toxicity; D019256:Cadmium Chloride; D002462:Cell Membrane / Q000187:drug effects*; D006372:Helix, Snails; D008195:Lymnaea; D008564:Membrane Potentials; D008627:Mercuric Chloride / Q000032:analysis / Q000633:toxicity; D008670:Metals / Q000032:analysis / Q000633:toxicity*; D009474:Neurons / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology; D014873:Water Pollutants / Q000032:analysis*; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D008670:Metals; D018377:Neurotransmitter Agents; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D002104:Cadmium; D008627:Mercuric Chloride; D019256:Cadmium Chloride