Comparative study of direct coronary vascular responses to diltiazem, adrenergic beta-blockers and other vasodilators in isolated, perfused dog and monkey coronary arteries.
The cannula-inserting method was used to examine the vascular responses of the isolated, perfused dog and monkey coronary arteries to a calcium antagonist (diltiazem), adrenergic beta-blockers (propranolol and pindolol), an antianginal drug (nicorandil) and vasodilators (hydralazine and papaverine). Propranolol and pindolol constricted the dog and monkey coronary arteries dose-dependently. Without any precontraction, hydralazine produced a biphasic response--a vasodilatation followed by a vasoconstriction--in the dog coronary artery, although it produced only a vasodilatation in the monkey coronary artery. Nicorandil and diltiazem dilated the uncontracted dog and monkey coronary arteries dose-dependently. The rank order of drug potency for inducing vasodilatation was diltiazem greater than nicorandil greater than hydralazine in both coronary arteries. These results indicate that the cannula-inserting method is useful to investigate the responses of the large epicardial dog and monkey coronary arteries to vasodilating drugs.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D002395:Catecholamines / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects*; D004110:Diltiazem / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006830:Hydralazine / Q000494:pharmacology; D066298:In Vitro Techniques; D008251:Macaca; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009536:Niacinamide / Q000031:analogs & derivatives / Q000494:pharmacology; D020108:Nicorandil; D010208:Papaverine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D014665:Vasodilator Agents; D009536:Niacinamide; D020108:Nicorandil; D006830:Hydralazine; D011189:Potassium Chloride; D010208:Papaverine; D004110:Diltiazem