title: Incidence of perforated and bleeding peptic ulcers before and after the introduction of H2-receptor antagonists.
abstract: The incidence of perforated and bleeding peptic ulcer requiring emergency surgery was studied in a defined population before and after the introduction of histamine H2-blockers. The incidence of these ulcer complications was unchanged from 1974 to 1984 with an incidence of ulcer perforation from 4 to 10/100,000 per year and of bleeding ulcer from 5 to 10/100,000, indicating that the H2-blockers have not changed the incidence of severe ulcer complications.
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004381:Duodenal Ulcer / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000453:epidemiology* / Q000601:surgery; D010439:Peptic Ulcer Perforation / Q000453:epidemiology* / Q000601:surgery; D013276:Stomach Ulcer / Q000150:complications* / Q000188:drug therapy
chemical_list: D006635:Histamine H2 Antagonists