[Action of idazoxan on tachycardia following electric stimulation of the thoracic sympathetic chain in the rat].
Selective stimulation of sympathetic nerves of the pithed rat (instead of stimulation of the whole sympathetic outflow) induced a frequency-dependent increase in heart rate. This electrical-induced tachycardia is decreased by clonidine and increased by idazoxan. The effect of idazoxan was not observed in experiments using continuous stimulation of the sympathetic outflow. It is then concluded that alpha 2 antagonists are able to increase the electrical-induced tachycardia in the pithed rat as they do in the dog or the cat.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D004146:Dioxanes / Q000494:pharmacology*; D004147:Dioxins / Q000494:pharmacology*; D004558:Electric Stimulation / Q000009:adverse effects; D005728:Ganglia, Sympathetic / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects*; D019329:Idazoxan; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013610:Tachycardia / Q000209:etiology / Q000503:physiopathology*
D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D004147:Dioxins; D019329:Idazoxan
Action de l'idazoxan sur la tachycardie consécutive à la stimulation électrique de la chaîne sympathique thoracique chez le rat.