A neuroendocrinological study of responders and non-responders to ceruletide treatment in chronic neuroleptic-resistant schizophrenia.
To define the characteristics of chronic schizophrenic patients who had responded poorly to treatment with ceruletide, several neuroendocrinological tests were carried out in 5 responders and 5 non-responders. Both thyroid-stimulating hormone and prolactin responses to thyrotropin-releasing hormone stimulation were within normal ranges in all subjects. The luteinizing hormone response to luteinizing hormone-releasing hormone, was slightly weaker in non-responders. There were no differences in the insulin tolerance test between responders and non-responders. Unusually delayed or prolonged growth hormone response to arginine infusion was observed in non-responders. These findings suggest dysfunction of the hypothalamo-pituitary system, especially of the arcuate nucleus and its functionally related areas, in non-responders.
D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002108:Ceruletide / Q000627:therapeutic use*; D002908:Chronic Disease; D004351:Drug Resistance; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007328:Insulin; D008297:Male; D009490:Neurosecretory Systems / Q000503:physiopathology*; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D013973:Thyrotropin-Releasing Hormone
D014150:Antipsychotic Agents; D007328:Insulin; D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D002108:Ceruletide; D005640:Follicle Stimulating Hormone