[Effect of cholinergic stimulation on spontaneous lymphocyte adhesion in vitro].
With the help of spontaneous lymphocyte adhesion test it was demonstrated that acetylcholine and carbacholine enhanced the adhesion of lymphocytes. The enhancement revealed was completely abolished by a specific M-cholinergic blocker--atropine, but not N-cholinergic blocker--hexonium. Thus, the enhancement of spontaneous human lymphocyte adhesion by cholinergic stimulation is mediated by M-cholinoreceptors. It is suggested that the phenomenon revealed is mediated by the enhancement of cGMP intracellular levels after cholinergic stimulation.
D000109:Acetylcholine / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D004347:Drug Interactions; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D011950:Receptors, Cholinergic / Q000187:drug effects*; D013268:Stimulation, Chemical
D006584:Hexamethonium Compounds; D011950:Receptors, Cholinergic; D018738:Hexamethonium; D001285:Atropine; D002217:Carbachol; D000109:Acetylcholine
Vliianie kholinergicheskoĭ stimuliatsii na spontannuiu adgeziiu limfotsitov in vitro.