beta-Endorphin modulates the inhibitory action of corticotropin-releasing factor on luteinizing hormone secretion.
The present study investigates the possible role of endogenous opioid peptides in mediating the inhibitory effect of corticotropin-releasing factor (CRF) on circulating luteinizing hormone (LH). The central injection of an antiserum against beta-endorphin (beta-END) reversed CRF-induced LH decrease in castrated male rats, while antisera raised against DYN-A or M-Enk were inactive. beta-END-(6-31) (2 nmole, icv), a beta-END antagonist, and beta-funaltrexamine (4.8 nmole, icv), a mu 1 opiate receptor antagonist, also reversed the effect of CRF on LH. Either kappa (Mr 1456 and Mr 2266) (10 mg/kg, ip), or delta (ICI 154,129) (10 nmole, icv) opiate receptor antagonists did not significantly modify the inhibitory effect of CRF on circulating LH levels. These results suggest that central beta-END participates in the inhibitory action of CRF on LH secretion.
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D004399:Dynorphins / Q000276:immunology / Q000502:physiology; D004723:Endorphins / Q000502:physiology*; D004744:Enkephalin, Methionine / Q000276:immunology / Q000502:physiology; D007106:Immune Sera; D007986:Luteinizing Hormone / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008297:Male; D009919:Orchiectomy; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin / Q000276:immunology / Q000502:physiology
D004723:Endorphins; D007106:Immune Sera; D004744:Enkephalin, Methionine; D001615:beta-Endorphin; D004399:Dynorphins; D007986:Luteinizing Hormone; D003346:Corticotropin-Releasing Hormone