Comparison of Edmonston-Zagreb and Schwarz strains of measles vaccine given by aerosol or subcutaneous injection.
The serological response to measles vaccine was tested in Bangladesh in groups of infants aged 4-6 months who received equal doses of Edmonston-Zagreb or Schwarz vaccine by subcutaneous injection or by aerosol. Seroconversion (as measured by the haemagglutination test) occurred in 62% of infants receiving Edmonston-Zagreb strain by injection compared with only 37% of those receiving Schwarz strain. Seroconversion occurred in 35% of those given Edmonston-Zagreb and 34% of those given Schwarz vaccine by aerosol. Edmonston-Zagreb strain appears more effective than Schwarz vaccine in this population and further studies are indicated in other populations where early measles immunisation is desirable.
D000336:Aerosols; D000914:Antibodies, Viral / Q000032:analysis; D001459:Bangladesh; D005260:Female; D006801:Humans; D007223:Infant; D007279:Injections, Subcutaneous; D008457:Measles / Q000276:immunology; D008458:Measles Vaccine / Q000008:administration & dosage* / Q000145:classification; D008459:Measles virus / Q000276:immunology; D012424:Rural Population; D013997:Time Factors; D014611:Vaccination / Q000379:methods
D000336:Aerosols; D000914:Antibodies, Viral; D008458:Measles Vaccine