In vitro enhancement of human platelet aggregation by somatostatin.
Very low concentrations of somatostatin (S-14) strongly potentiate the in vitro aggregation induced by collagen, ristocetin and arachidonic acid, but not that induced by ADP or epinephrine, in both human platelet rich plasmas and gel-filtered platelet preparations. Desensitization phenomena may be induced either by repeated addition of S-14 or long lasting contact between S-14 and platelets.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D002850:Chromatography, Gel; D003094:Collagen / Q000494:pharmacology; D004357:Drug Synergism; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D012310:Ristocetin / Q000494:pharmacology; D013004:Somatostatin / Q000494:pharmacology*
D001095:Arachidonic Acids; D012310:Ristocetin; D016718:Arachidonic Acid; D013004:Somatostatin; D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine