[Significance of the dopamine-blocking and m-choline-blocking components in the antiapomorphine action of neuroleptics].
In experiments on rats and mice the correlation between the ability of neuroleptics to antagonize apomorphine induced stereotypy and to block central dopamine and muscarinic acetylcholine receptors was studied. The analysis showed significant correlation (v = 0.76; P less than 0.05) between antistereotypic effects of drugs and their ability to inhibit 3H-spiperone binding to rat striated tissue. However, no correlation was found between antistereotypic effect of neuroleptics and their ability to block 3H-quinuclidinyl benzylate binding or arecoline-induced tremor.
D000818:Animals; D014150:Antipsychotic Agents / Q000032:analysis / Q000494:pharmacology*; D001058:Apomorphine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001115:Arecoline / Q000037:antagonists & inhibitors / Q000494:pharmacology; D002794:Choline / Q000037:antagonists & inhibitors*; D018492:Dopamine Antagonists; D005260:Female; D008297:Male; D051379:Mice; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects; D013329:Structure-Activity Relationship; D014202:Tremor / Q000139:chemically induced
D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D001115:Arecoline; D001058:Apomorphine; D002794:Choline
Znachenie dofaminoblokiruiushchego i m-kholinoblokiruiushchego komponentov v antiapomorfinovom deĭstvii neĭroleptikov.