Bi-directional changes in sham feeding in the rat produced by benzodiazepine receptor ligands.
Both the real and sham intake of a 5% sucrose solution were increased by midazolam (3 mg/kg IP), a benzodiazepine agonist. In contrast, both the real and sham intakes of a 20% sucrose solution were reduced by Ro15-3505 (a benzodiazepine antagonist with weak inverse agonist properties) and by FG 7142 (a beta-carboline inverse agonist). These data demonstrate that drugs acting at benzodiazepine receptors can bi-directionally alter ingestional responses, probably by modulation of the oropharyngeal control of consumption.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001067:Appetite Depressants / Q000494:pharmacology; D001570:Benzodiazepinones / Q000494:pharmacology; D002243:Carbolines / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D008297:Male; D008874:Midazolam / Q000494:pharmacology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects*; D013649:Taste / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D001067:Appetite Depressants; D001570:Benzodiazepinones; D002243:Carbolines; D011963:Receptors, GABA-A; C035874:FG 7142; C040725:Ro 15-3505; D008874:Midazolam