Intra-individual variation of analytes in serum from patients with chronic liver diseases.
The average biological intra-individual CV in 20 patients with chronic liver diseases (CLD), estimated for 14 analytes during a stationary phase, significantly exceeded that for a normal group in the cases of Na+, K+, Cl-, total protein, albumin, cholinesterase, hemoglobin, and alpha-amylase; it did not differ significantly from the normal group for cholesterol, alkaline phosphatase, aspartate aminotransferase, and alanine aminopeptidase; and it was significantly lower than in the normal group for alanine aminotransferase and gamma-glutamyltransferase. There were no significant sex-related differences in mean intra-individual variation in CLD patients. Individual values were gaussian-distributed for all analytes, including enzymes. The estimated biological component of intra-individual variation and the analytical variation as determined for each laboratory can be used to derive decision-making criteria in monitoring CLD.
D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D002802:Cholinesterases / Q000097:blood; D002908:Chronic Disease; D004573:Electrolytes / Q000097:blood; D005260:Female; D006521:Hepatitis, Chronic / Q000097:blood; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood; D008107:Liver Diseases / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013223:Statistics as Topic; D000516:alpha-Amylases / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D001798:Blood Proteins; D004573:Electrolytes; D002784:Cholesterol; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase; D002802:Cholinesterases; D000469:Alkaline Phosphatase; D000516:alpha-Amylases