Tuftsin a natural peptide with antiviral activity--structural basis of its action.
The influence of tuftsin--the natural phagocytosis stimulating tetrapeptide and its elongated analogues--on the mortality of encephalomyocarditis virus-infected NMRI mice was investigated. It seems that amino acids elongation in the parent peptide chain does not result in significant increase of antiviral activity of the compounds tested.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D004769:Enterovirus Infections / Q000188:drug therapy* / Q000517:prevention & control; D008297:Male; D004680:Maus Elberfeld virus; D051379:Mice; D013329:Structure-Activity Relationship; D014405:Tuftsin / Q000031:analogs & derivatives / Q000494:pharmacology*
D000998:Antiviral Agents; D014405:Tuftsin