Expression of the myc protooncogene in canine rhabdomyosarcoma.
The expression of the protooncogene c-myc in a canine rhabdomyosarcoma was examined. It was found that this highly malignant tumour contained vast quantities of RNA that hybridized with a cDNA probe for c-myc. Restriction fragment length analysis after endonuclease digestion of tumour DNA did not reveal any rearrangements in this gene locus. The potential role of this oncogene in the development of canine rhabdomyosarcoma is discussed.
D000818:Animals; D001859:Bone Neoplasms / Q000235:genetics / Q000662:veterinary; D004247:DNA / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005786:Gene Expression Regulation; D012150:Polymorphism, Restriction Fragment Length; D011519:Proto-Oncogenes; D012334:RNA, Neoplasm / Q000032:analysis; D012208:Rhabdomyosarcoma / Q000235:genetics* / Q000662:veterinary
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D004247:DNA