[Renal dipeptidylpeptidase IV excretion in drug-induced kidney changes].
The course of the excretion of dipeptidyl-peptidase IV (DP IV)-alanine aminopeptidase, beta-glucuronidase and total protein with the urine was investigated during the treatment of 11 patients with pyelonephritis with gentamicin, after application of a renal radiographic contrast medium in 7 patients with arterial hypertension and after regional perfusion of an extremity in 10 patients with malignant melanoma. In the reference group in male test persons with 147.0 nmol/s X l a higher DP IV activity in the urine was recognized than in the female test persons (100.0 nmol/s X l). After application of the drugs a rhythmically intermitting increased excretion of all enzymes mentioned develops. The study confirms the usuability of the DP IV-activity for enzymological investigations of the urine.
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000201:enzymology; D000293:Adolescent; D000328:Adult; D000626:Aminopeptidases / Q000652:urine; D018826:CD13 Antigens; D002512:Cephalothin / Q000009:adverse effects; D010478:Chemotherapy, Cancer, Regional Perfusion; D003973:Diatrizoate / Q000009:adverse effects; D018819:Dipeptidyl Peptidase 4; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000652:urine*; D005260:Female; D005839:Gentamicins / Q000009:adverse effects; D005966:Glucuronidase / Q000652:urine; D006801:Humans; D006977:Hypertension, Renal / Q000000981:diagnostic imaging; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008545:Melanoma / Q000188:drug therapy; D008727:Methotrexate / Q000009:adverse effects; D008875:Middle Aged; D011704:Pyelonephritis / Q000188:drug therapy; D012878:Skin Neoplasms / Q000188:drug therapy; D014567:Urography
D005839:Gentamicins; D003973:Diatrizoate; D005966:Glucuronidase; D000626:Aminopeptidases; D018826:CD13 Antigens; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D018819:Dipeptidyl Peptidase 4; D002512:Cephalothin; D008727:Methotrexate
Renale Dipeptidylpeptidase-IV-Ausscheidung bei medikamenteninduzierten Nierenalterationen.