title: [Prevention of ulcer disease].
abstract: H2-receptor antagonists, sucralfate, pirenzepine and antacids are effective, when given prophylactically, in preventing relapse of peptic ulcer. H2-receptor antagonists and sucralfate are the most widely used and are virtually free of side effects. Cessation of smoking, a balanced diet and a calm life-style are also part of the prophylaxis. The incidence of relapse is reduced by 50-80% over a period of 1-2 years. The economic and clinical benefits of prophylaxis are shown. It is indicated in cases of chronic, relapsing ulcers; complicated ulcers; in medically compromised subjects and in those with heavy responsibilities. Prophylaxis is unduly costly when given after a first episode of peptic ulcer or when episodes are infrequent. For patients with one or two episodes a year the decision to give prophylaxis depends on the patient's wishes. Prophylaxis of stress-induced haemorrhagic lesions depends on the securing of an intragastric pH greater than 3.5-5, usually achieved by hourly administration of antacids. Methylated prostaglandins and H2-receptor antagonists can prevent drug induced peptic lesions. Under the protection of one of these drugs it is possible to continue antiinflammatory treatment at the lowest possible dose.
mesh_terms: D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004032:Diet; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D008019:Life Style; D010437:Peptic Ulcer / Q000517:prevention & control*; D012008:Recurrence; D013312:Stress, Physiological / Q000517:prevention & control; D013392:Sucralfate / Q000627:therapeutic use; D014629:Vagotomy, Proximal Gastric
chemical_list: D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D013392:Sucralfate
vernacular_title: Prophylaxie de la maladie ulcéreuse.