The metabolism of atropine in man.
A metabolic pattern of atropine in man, based on the detection of radiolabelled products in urine by high performance liquid chromatography after administration of [3H]atropine sulphate to a normal volunteer is proposed. Noratropine (24%), atropine-N-oxide (equatorial isomer) (15%), tropine (2%) and tropic acid (3%) appear to be the major metabolites, while 50% of the administered dose is excreted as apparently unchanged atropine. No conjugates were detectable. Evidence that atropine is present as (+)-hyoscyamine was found, suggesting that stereoselective metabolism of atropine probably occurs.
D001285:Atropine / Q000378:metabolism*; D001286:Atropine Derivatives / Q000652:urine; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006801:Humans; D010666:Phenylpropionates / Q000652:urine; D013237:Stereoisomerism; D014326:Tropanes / Q000652:urine
D001286:Atropine Derivatives; D010666:Phenylpropionates; D014326:Tropanes; D001285:Atropine; C005864:tropine; C011377:tropic acid; C038490:noratropine