title: Development of neurochemical separation of ON and OFF channels at retinal ganglion cells.
abstract: Anatomical and physiological segregation of neurons into ON (brightening detector) and OFF (darkening detector) channels in the retina and subsequent visual system ensure the high sensitivity required for contrast detection and spatial discrimination. This segregation is finest at the visual axis. Neurochemically, ON and OFF ganglion cells at the visual axis seem to be distinguished by different inhibitory transmitters but not excitatory transmitters. Microiontophoretic studies of inhibitory transmitters on the retinal ganglion cells in kittens and adult cats suggest that this neurochemical distinction is poor in immature ganglion cells at the visual axis. Initially both ON and OFF cells seem to be supplied by GABAergic, glycinergic, and catecholaminergic amacrine cells, but in adults, ON cells remain supplied only by GABAergic amacrines, while OFF cells are supplied by glycinergic amacrines. Postnatal elimination of multiple inputs and strengthening of the appropriate inputs, as seen in the central nervous system, also seem to occur at the retinal neurotransmitter synapses during development.
mesh_terms: D000818:Animals; D002415:Cats / Q000254:growth & development / Q000502:physiology; D004298:Dopamine / Q000494:pharmacology; D018492:Dopamine Antagonists; D004594:Electrophysiology; D018756:GABA Antagonists; D005998:Glycine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009433:Neural Inhibition; D018377:Neurotransmitter Agents / Q000502:physiology*; D012160:Retina / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000502:physiology*; D014792:Visual Acuity; D014795:Visual Pathways / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D018492:Dopamine Antagonists; D018756:GABA Antagonists; D018377:Neurotransmitter Agents; D005680:gamma-Aminobutyric Acid; D005998:Glycine; D004298:Dopamine