title: Disappearance of CD4-lymphocyte circadian cycles in HIV-infected patients: early event during asymptomatic infection.
abstract: Circadian variations have been observed in peripheral blood lymphocyte counts in normal subjects; they usually reflect variations in absolute CD4-cell count. For this population, nadir occurs around 0800 h (basal value) and the peak value occurs at midnight (1.6 times the 0800-h value). This cycle is thought to be of major importance in the efficacy of the immune response because it expresses the migration of lymphocytes into lymphoid organs.
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000503:physiopathology; D000943:Antigens, Differentiation; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D002940:Circadian Rhythm; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D010641:Phenotype
chemical_list: D000943:Antigens, Differentiation