title: Modulation of granulocyte functions by bacterial exotoxin and endotoxins.
abstract: The modulation of granulocyte functions by bacterial exotoxins (Streptolysin O, alveolysin, theta toxin) and endotoxins from salmonella and lipid A is described here. Incubation of polymorphonuclear granulocytes with thiol-activated toxins resulted in an increased leukotriene generation. Toxin-pretreated PMNs revealed an increased omega oxidation of LTB4, which may explain why toxin-stimulated cells release more LTC4 than LTB4. Furthermore, toxin-pretreated PMNs showed a decreased leukotriene generation on subsequent stimulation with the Ca-ionophore A 23187 or opsonized zymosan.
mesh_terms: D001426:Bacterial Proteins; D001427:Bacterial Toxins / Q000276:immunology; D003016:Clostridium perfringens; D004731:Endotoxins / Q000276:immunology*; D005098:Exotoxins / Q000276:immunology*; D006460:Hemolysin Proteins / Q000276:immunology; D006801:Humans; D007975:Leukotriene B4 / Q000378:metabolism*; D017999:Leukotriene E4; D008050:Lipid A / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology*; D009930:Organic Chemicals; D013189:SRS-A / Q000031:analogs & derivatives / Q000378:metabolism; D012475:Salmonella; D013301:Streptolysins / Q000276:immunology
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004731:Endotoxins; D005098:Exotoxins; D006460:Hemolysin Proteins; D008050:Lipid A; D009930:Organic Chemicals; D013189:SRS-A; D013301:Streptolysins; C025964:streptolysin O; D007975:Leukotriene B4; C020452:Clostridium perfringens theta-toxin; D017999:Leukotriene E4; C014963:alveolysin