Olsalazine as an alternative therapy in a patient with sulfasalazine-induced eosinophilic pneumonia.
A man with Crohn's colitis developed eosinophilic pneumonia after treatment with sulfasalazine. Challenge with sulfapyridine revealed that this component of sulfasalazine was the likely causative agent. Treatment with olsalazine, a 5-aminosalicylic acid compound (disodium-azodisalicylate), was well tolerated without recurrence of pulmonary symptoms.
D000328:Adult; D000636:Aminosalicylic Acids / Q000627:therapeutic use*; D003092:Colitis / Q000188:drug therapy; D003424:Crohn Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011657:Pulmonary Eosinophilia / Q000139:chemically induced*; D012460:Sulfasalazine / Q000009:adverse effects*
D000636:Aminosalicylic Acids; D012460:Sulfasalazine; C032587:olsalazine