title: Economy in the use of muscle relaxants. Vecuronium after pancuronium.
abstract: Vecuronium is an intermediate duration, non-depolarising muscle relaxant. When used during prolonged procedures, it may be given by intermittent injection, by continuous infusion or by a single very large dose at the start of anaesthesia. It may also be used to maintain relaxation after the initial use of a long-acting agent, such as pancuronium. This study demonstrates that the effect of a dose of vecuronium used in this fashion is increased when interaction with pancuronium takes place. The clinical and theoretical implications of this observation are discussed.
mesh_terms: D000328:Adult; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009469:Neuromuscular Junction / Q000502:physiology*; D010197:Pancuronium / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors; D014673:Vecuronium Bromide / Q000494:pharmacology*
chemical_list: D014673:Vecuronium Bromide; D010197:Pancuronium