[The anti-H1-histaminic and antimuscarinic effect of 2- and 4-[benzyl-(2-dimethylaminoethyl)amino]pyrimidine compounds].
This paper reports the synthesis of 2- and 4- [benzyl-(2-dimethylaminoethyl)amino]pyrimidine compounds and the evaluation of their inhibitory properties against histamine (H1), acetylcholine and barium chloride, on guinea pig isolated ileum. 4-[p.Methoxybenzyl-(2-dimethylaminoethyl)amino]-2-methoxy-pyrimidine (VIII) is shown to possess H1 receptor antagonist activity, with a potency similar to that observed for Tonzylamine. By contrast, a specific, although weak, antimuscarinic effect is displayed by 4-[benzyl-(2-dimethylaminoethyl)amino]-2-methoxy-5-methylthio-pyrimidine (XII).
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D001463:Barbiturates; D001464:Barium / Q000037:antagonists & inhibitors; D017609:Barium Compounds; D055598:Chemical Phenomena; D002621:Chemistry; D002712:Chlorides; D005029:Ethylenediamines / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis*; D051379:Mice; D010276:Parasympatholytics / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects
D001463:Barbiturates; D017609:Barium Compounds; D002712:Chlorides; D005029:Ethylenediamines; D006634:Histamine H1 Antagonists; D010276:Parasympatholytics; D011743:Pyrimidines; C024986:barium chloride; D001464:Barium; D000109:Acetylcholine
Effetti anti H1-istaminici e antimuscarinici di composti 2-e 4-[benzil-(2-dimetilaminoetil)amino]pirimidinici.