DNA polymorphism and the study of disease associations.
Recombinant DNA approaches to disease analysis may be as applicable to studies of disease association as they are to the analysis and diagnosis of single-gene defects. Population and/or family association analyses, using restriction fragment length polymorphisms around candidate genes as markers, have been employed to study conditions such as atherosclerosis and disease with an HLA-association. Progress made to date in disease-association studies using recombinant DNA methodology is reviewed, the rationale behind such studies is examined and associated problems and pitfalls discussed.
D000483:Alleles; D001161:Arteriosclerosis / Q000235:genetics; D004247:DNA / Q000032:analysis*; D004274:DNA, Recombinant; D004198:Disease Susceptibility / Q000175:diagnosis; D004992:Ethics, Medical; D005787:Gene Frequency; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D004274:DNA, Recombinant; D005819:Genetic Markers; D006680:HLA Antigens; D004247:DNA