Drinking induced by cellular dehydration in the quail, Coturnix coturnix japonica.
1. Drinking was induced in water-replete quail 5-10 min after intravenous injection of hypertonic NaCl (0.69 osmol/l) or sucrose (1.06 osmol/l), but hypertonic urea (2.78 osmol/l) failed to induce drinking. 2. The birds drank approximately the amount required to dilute the injected solutes to isotonicity for each given dose of NaCl or sucrose. 3. The plasma angiotensin II level decreased after injection of 7% NaCl (2.5 osmol/l), but it increased after injection of an equi-osmolar solution of sucrose (65%). 4. Plasma osmolality and Na+ concentration returned quickly to control levels, and then decreased further, after injection of 7% NaCl or 65% sucrose. 5. Blood volume and blood pressure increased immediately after injection of 7% NaCl or 65% sucrose. 6. These results show that drinking is induced after injection of hypertonic solutions exclusively by cellular dehydration, and other regulatory mechanisms for thirst, such as extracellular dehydration and the renin-angiotensin system, are rather inhibitory after injection of hypertonic NaCl.
D000804:Angiotensin II / Q000097:blood; D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D003370:Coturnix / Q000502:physiology*; D004326:Drinking; D006982:Hypertonic Solutions; D007700:Kinetics; D008297:Male; D009994:Osmolar Concentration; D011784:Quail / Q000502:physiology*; D012964:Sodium / Q000097:blood; D012965:Sodium Chloride / Q000008:administration & dosage; D013395:Sucrose / Q000008:administration & dosage; D013894:Thirst; D013997:Time Factors; D014508:Urea / Q000008:administration & dosage
D006982:Hypertonic Solutions; D000804:Angiotensin II; D012965:Sodium Chloride; D013395:Sucrose; D014508:Urea; D012964:Sodium