Effect of bile salts and of fusidic acid on HIV-1 infection of cultured cells.
Bile salts completely inactivated human immunodeficiency virus type 1 (HIV-1) in vitro and, unexpectedly, completely destroyed all the cultured persistently HIV-1 infected T cells. Fusidic acid, which likewise possesses the properties of an anionic surfactant, inactivated HIV-1 only at concentrations toxic to uninfected cultured cells. Bile salts or their derivatives, and other anionic surfactants, could be of therapeutic value in HIV-1 infections.
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D001647:Bile Acids and Salts / Q000494:pharmacology* / Q000627:therapeutic use; D002478:Cells, Cultured; D005672:Fusidic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D006678:HIV / Q000187:drug effects*; D006801:Humans
D001647:Bile Acids and Salts; D005672:Fusidic Acid