Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons.
Ibotenic acid injections into the nucleus basalis (Ch4) resulted in a near-total loss of cortical cholinesterase fibers. This loss of cholinergic input is irreversible for at least 6 months. The degeneration of cholinergic input has no transsynaptic effect upon the number of cortical somatostatinergic, cholinergic and cholinesterase-positive (cholinoceptive) neurons.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001479:Basal Ganglia / Q000166:cytology / Q000187:drug effects*; D002452:Cell Count; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002799:Cholinergic Fibers / Q000187:drug effects*; D007051:Ibotenic Acid / Q000633:toxicity*; D007124:Immunoenzyme Techniques; D008297:Male; D009474:Neurons / Q000145:classification / Q000187:drug effects; D010080:Oxazoles / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000378:metabolism*
D010080:Oxazoles; D007051:Ibotenic Acid; D013004:Somatostatin; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase