[Biological activity of the sum of the valepotriates isolated from Valeriana alliariifolia].
The native sum of valepotriates isolated from Val. alliariifolia Adams which was named valiracyl is an agent of low toxicity and exerts a pronounced neurotropic effect. Valiracyl suppresses the orientation reflex of animals in an "open field", decreases a spontaneous and caffeine-stimulated motor activity, potentiates and prolongs the action of barbiturates, significantly reduces aggressiveness of animals, decreases sensitivity to the convulsant effects of corasol and thiosemicarbazide, produces the antihypoxic and mild myorelaxant actions. The neurotropic effects of valiracyl are related to increased level of the GABA inhibition mediator and decreased intensity of bioenergetic processes in the brain.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001921:Brain / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D039823:Iridoids; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D010946:Plants, Medicinal; D011714:Pyrans / Q000494:pharmacology*; D051381:Rats; D014632:Valerian; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D039823:Iridoids; D011714:Pyrans; C009643:valtrates (combination); D005680:gamma-Aminobutyric Acid
Biologicheskaia aktivnost' summy valepotriatov, vydelennykh iz valeriany chesnochnikolistnoĭ.