[Search for and study of biologically active substances with psychotropic activity among the N-nicotinoyl derivatives of glutamic and gamma-aminobutyric acids].
Four new derivatives of glutamic and gamma-aminobutyric acids influencing the central nervous system were produced. By the character of their action they refer to the substances of the sedating tranquilizing type without the myorelaxant component. The drug activity degree depends on its ability to penetrate through cell membranes that is in turn determined by the structure of the compound.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009539:Nicotinic Acids / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D005971:Glutamates; D009539:Nicotinic Acids; D011619:Psychotropic Drugs; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid
Poisk i izuchenie biologicheski aktivnykh veshchestv s psikhotropnoĭ aktivnost'iu v riadu N-nikotinoil'nykh proizvodnykh glutaminovoĭ i gamma-aminomaslianoĭ kislot.