title: Swedish trial in old patients with hypertension. A prospective multicentre study in Swedish primary health care.
abstract: The Swedish trial in old patients with hypertension was initiated by the Swedish League against Hypertension. It will be conducted as a prospective multicentre study in Swedish primary health care, and will comprise approximately 2 000 patients on active treatment and 2 000 on placebo to be studied for three years. The primary goal with this study is to investigate whether pharmacological treatment of hypertension in men and women aged 70-84 years will reduce the incidence of fatal and nonfatal cardiac and cerebrovascular disease. Before starting the main trial a pilot study comprising 400 patients will be carried out during one year to evaluate all logistical aspects of the study. This pilot study commenced in October 1985.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000584:Amiloride / Q000627:therapeutic use; D001262:Atenolol / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D010869:Pindolol / Q000627:therapeutic use; D011446:Prospective Studies; D011897:Random Allocation; D013548:Sweden
chemical_list: D000319:Adrenergic beta-Antagonists; D004338:Drug Combinations; D006852:Hydrochlorothiazide; D001262:Atenolol; C010247:amiloride, hydrochlorothiazide drug combination; D000584:Amiloride; D010869:Pindolol; D008790:Metoprolol