title: A comparison of the PD35-sGaw and PD20-FEV1 in assessment of the effect of oral anti-allergic compounds on the immediate asthmatic response to inhaled allergen.
abstract: Assessment of two methods of measuring airway response to allergen challenge showed that results obtained using FEV1 correlated well with those obtained using sGaw irrespective of pre-treatment. Significantly smaller amounts of allergen were required to reduce the sGaw by 35% than to reduce the FEV1 by 20%, although both indices discriminated equally well between the effects of drugs on airway responses to challenge.
mesh_terms: D000328:Adult; D000403:Airway Resistance; D000485:Allergens; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D005541:Forced Expiratory Volume; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007665:Ketotifen / Q000627:therapeutic use*; D008297:Male; D009930:Organic Chemicals
chemical_list: D000485:Allergens; D001993:Bronchodilator Agents; D006634:Histamine H1 Antagonists; D009930:Organic Chemicals; C053424:HG 37-639; D007665:Ketotifen