The influence of viscosity on the migration of chloramphenicol and 4-hydroxybenzoic acid through glycerogelatin gels.
Migration of chloramphenicol and 4-hydroxybenzoic acid from solutions in 1-octanol into Glycerol Suppository Base, BP and soft gelatin capsule shells is reported. Rates of migration through the gels, quantified in terms of diffusion coefficients, are given. An electron spin resonance probing technique was used to determine the microscopic viscosity. The latter, rather than the bulk viscosity, was shown to be the major rheological influence on the rate of diffusion.
D002701:Chloramphenicol / Q000032:analysis*; D004058:Diffusion; D004578:Electron Spin Resonance Spectroscopy; D005780:Gelatin; D005782:Gels; D062385:Hydroxybenzoates / Q000032:analysis*; D010226:Parabens; D013696:Temperature; D014783:Viscosity
D005782:Gels; D062385:Hydroxybenzoates; D010226:Parabens; D002701:Chloramphenicol; D005780:Gelatin; C038193:4-hydroxybenzoic acid