Psychotropic drug interactions in the patient with late-onset psychosis and mood disorder. Part 1.
We have discussed major drug interactions involving neuroleptics and MAOIs. Interactions in the older patients are probably more frequent owing to the larger number of medications used. When interactions do occur in the elderly, the effects may be more severe and of a longer duration than those seen in younger patients. Many (but not all) drug-drug interactions are predictable, given a basic knowledge of the pharmacologic effects of the agents in question. In a number of cases, there are therapeutic alternatives to agents that have been reported to interact with psychotropic medications. The clinician should consider the likelihood of adverse drug interactions to be a significant concern as the age of the patient and the number of concurrently administered medications increase.
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D004347:Drug Interactions; D006801:Humans; D008094:Lithium / Q000009:adverse effects; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects*; D010276:Parasympatholytics / Q000009:adverse effects
D014150:Antipsychotic Agents; D008996:Monoamine Oxidase Inhibitors; D010276:Parasympatholytics; D008094:Lithium