S-oxalylglutathione is a substrate for gamma-glutamyltransferase (GGT). Implications for the role of GGT in cell proliferation.
With glycylglycine or water as acceptor, bovine kidney gamma-glutamyltransferase catalyzes reactions of the known mammalian metabolite, S-oxalylglutathione, at rates comparable to those of L-gamma-glutamyl-p-nitroanilide, a known good substrate. N-Oxalyl-cysteinylglycine is the eventual product of the former reaction. Since oxalyl thiolesters are implicated as important cell proliferation inhibitors, it is proposed that this reaction plays a major role in controlling cell proliferation.
D000818:Animals; D002417:Cattle; D002455:Cell Division; D005978:Glutathione / Q000031:analogs & derivatives* / Q000378:metabolism; D006868:Hydrolysis; D007668:Kidney / Q000201:enzymology; D007700:Kinetics; D013379:Substrate Specificity; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
C052145:S-oxalylglutathione; D005723:gamma-Glutamyltransferase; D005978:Glutathione