Studies on pathogenesis of fowl pox: virological study.
One-month-old WLH chickens were inoculated with a field isolate of fowl pox virus (FPV) by intradermal (i.d.) and intratracheal (i.t.) routes. In intradermally infected chickens, the virus in titrable amounts was first detected in the skin at the inoculation site on day 2 and in lungs on day 4 followed by viraemia on the day 5 post-infection (p.i.). Subsequently the virus was recovered from liver, spleen, kidney and brain, but not from the heart. The chickens infected by i.t. route showed an almost similar outcome with minor differences as the virus was first demonstrated in the lungs on day 2 p.i., viraemia occurred on day 4 p.i. Initiation of pocks at the inoculation site in i.d. infected birds was observed on days 3 to 4 p.i., generalized cutaneous pock lesions appeared from 7 to 8 days p.i.
D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D005586:Fowlpox / Q000209:etiology* / Q000382:microbiology; D005587:Fowlpox virus / Q000302:isolation & purification / Q000472:pathogenicity; D007267:Injections; D007271:Injections, Intradermal; D008168:Lung / Q000382:microbiology; D012867:Skin / Q000382:microbiology; D014018:Tissue Distribution; D014132:Trachea; D014766:Viremia / Q000209:etiology