[H2-antagonistic activity of the impromidine analog, cyanoguanidine. 37. H2 antihistaminics].
In studies on structure-activity relationships among impromidine-like histamine H2-receptor agonists, the synthesis of impromidine analogous guanidines led to the corresponding intermediate cyanoguanidines. The latter are structurally related to cimetidine. For that reason they were tested for H2-antagonistic activity on the isolated guinea-pig atrium. Compound 5h proved to be significantly more potent than cimetidine. Derivatives with branched thioether moiety were devoid of affinity. The results are consistent with existing structure-activity relationships.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006146:Guanidines / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006635:Histamine H2 Antagonists; D007093:Imidazoles / Q000494:pharmacology*; D017446:Impromidine; D066298:In Vitro Techniques; D013329:Structure-Activity Relationship
D006146:Guanidines; D006635:Histamine H2 Antagonists; D007093:Imidazoles; D017446:Impromidine; C004711:dicyandiamido
H2-antagonistische Aktivität Impromidin-analoger Cyanoguanidine. 37. Mitteilung: H2-Antihistaminika.