title: Effects of two-thirds hepatectomy on sulfobromophthalein handling by the rat liver.
abstract: The modifications in the hepatic transport of sulfobromophthalein (BSP) were studied after partial hepatectomy (p.h.) in Wistar rats. The biliary excretion of BSP, injected i.v. at 150 mumol/kg, decreased in the early periods after p.h., with a disappearance of the choleretic effect induced by the dye in sham-operated animals. The impairment in the biliary BSP excretion corresponded to the conjugated fraction and was accompanied by a lowered glutathione S-transferase activity in the liver.
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D006498:Hepatectomy; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism; D013448:Sulfobromophthalein / Q000378:metabolism*
chemical_list: D001647:Bile Acids and Salts; D013448:Sulfobromophthalein; D012964:Sodium