Supraventricular tachyarrhythmias after coronary bypass surgery--a double blind randomized trial of prophylactic low dose propranolol.
In the present study 75 patients were double blind randomized either to receive 10 mg propranolol orally 4 times a day (35 patients) or a placebo (40 patients). Episodes of clinically important supraventricular tachyarrhythmias were recorded in the first 4 postoperative days. They appeared in 5 of 35 patients receiving propranolol and in 5 of 40 patients receiving placebo (no statistically significant difference). In conclusion this study indicates the need for further evaluation to clarify if low-dose propranolol or any other drug is effective in reducing the frequency of SVT in the early postoperative period after coronary artery bypass surgery.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D006801:Humans; D007432:Intraoperative Period; D009203:Myocardial Infarction / Q000150:complications; D011184:Postoperative Period; D011433:Propranolol / Q000008:administration & dosage* / Q000627:therapeutic use; D011897:Random Allocation; D013617:Tachycardia, Supraventricular / Q000150:complications / Q000209:etiology / Q000517:prevention & control*
D000319:Adrenergic beta-Antagonists; D011433:Propranolol