Beta-adrenergic effects on cerebral circulation.
Noradrenaline, adrenaline, and isoprenaline were infused intracarotidly and the regional cerebral blood flow measured with the intracarotid injection-stationary detector method in patients undergoing carotid angiography. No effect was seen, and beta blockade with intracarotid propranolol also had no effect. The adrenergic effects on cerebral blood vessels are probably neurogenic, and circulating adrenergic agonists and antagonists are unlikely to play a role. Pertubations of adrenergic substances in blood are therefore unlikely to be important in migraine pathophysiology.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D001812:Blood-Brain Barrier / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy*; D010100:Oxygen / Q000097:blood; D011433:Propranolol / Q000627:therapeutic use; D014655:Vascular Resistance / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D002245:Carbon Dioxide; D011433:Propranolol; D010100:Oxygen