[Effect of adrenoblockers on the analgesic effect of GABA-positive preparations].
The experiments on rats have shown that selective alpha 1 and alpha 2 adrenoceptor blockers (prazosin and yohimbine) and an inhibitor of dopamine-beta-hydrolase FD-008 failed to change the antinociceptive effect of baclofen, a direct GABAB receptor agonist. The antinociceptive effect of THIP and depakin, acting predominantly on GABAA receptors, was significantly reduced by prazosin, FD-008 and yohimbine in vocalization test. In tail-flick test the analgetic effect of THIP and depakin was not altered by prazosin and FD-008, but was increased by yohimbine. The role of adrenergic mechanisms in GABAA and GABAB receptor-mediated analgesia is discussed.
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors; D004347:Drug Interactions; D008297:Male; D010146:Pain / Q000188:drug therapy*; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
D000317:Adrenergic alpha-Antagonists; D000700:Analgesics; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D004299:Dopamine beta-Hydroxylase
Vliianie adrenoblokatorov na boleutoliaiushchiĭ éffekt GAMK-polozhitel'nykh preparatov.