No effects on sleep of a histamine H1-receptor antagonist: temelastine.
Twelve volunteer poor sleepers of mean age 57 years took placebo on each of 3 consecutive nights, and temelastine 100 mg on 3 consecutive nights in a double-blind balanced order study. Sleep in the EEG laboratory was unaffected by the drug.
D000368:Aged; D004311:Double-Blind Method; D004569:Electroencephalography; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011744:Pyrimidinones / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects
D006634:Histamine H1 Antagonists; D011744:Pyrimidinones; C049054:temelastine