GABA agonists in cebus monkeys with neuroleptic-induced persistent dyskinesias.
Tetrahydroisoxazolopyridinol (THIP), a GABA receptor agonist, gamma-acetylenic-GABA(GAG) and gamma-vinyl-GABA(GVG), two GABA transaminase inhibitors were given in single parenteral doses to three Cebus apella monkeys with persistent dyskinetic movements induced by earlier long-term administration of haloperidol. High doses of THIP temporarily abolished dyskinesias but also caused bradykinesia, ataxia, dystonia and myoclonic jerks. GAG and GVG reduced dyskinesias to a lesser extent and with fewer side effects. Whether the observed antidyskinetic effect is secondary to the concomitant general toxic effects or if these drugs have a specific antidyskinetic action remains an open question.
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors; D000480:Alkynes; D000614:Aminocaproates / Q000627:therapeutic use; D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects*; D002428:Cebus; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy*; D005260:Female; D007555:Isoxazoles / Q000627:therapeutic use; D008297:Male; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000480:Alkynes; D000614:Aminocaproates; D014150:Antipsychotic Agents; D007555:Isoxazoles; D005680:gamma-Aminobutyric Acid; C013785:4-amino-5-hexynoic acid; D000612:4-Aminobutyrate Transaminase; D020888:Vigabatrin; C015542:gaboxadol