Significance of chromosome 14 anomaly at band 14q11 in Japanese patients with adult T-cell leukemia.
The chromosomes of leukemic blood cells in eight Japanese patients with acute adult T-cell leukemia (ATL) were examined by a direct method or short-term culture method without any mitogens. Six patients showed a chromosome 14 anomaly with a break at band q11-13: inv(14)(q11q32) in two patients, t(11;14)(p13;q13) in one patient, t(14;14)(q11;q32) in addition to del(14)(q11q13) in another, and only del(14)(q11q13) in two patients. Thus, a proximal 14q rearrangement exists in ATL as in other types of T-cell malignancies. Based on these facts, the pathogenesis of ATL is discussed in reference to the literature.
D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002875:Chromosomes; D006800:Deltaretrovirus Infections / Q000235:genetics*; D006801:Humans; D007564:Japan; D007621:Karyotyping; D011289:Preleukemia / Q000235:genetics