[Analysis of the effect of glutamic acid diethyl ester on synaptic processes in the ampullae of Lorenzini of the skate].
The effects of glutamic acid diethylester (GDEE) on the electrical activity of the ampullae of Lorenzini were studied in skates. GDEE (10(-6)-10(-4) M) caused a decrease in frequency of afferent discharges in all receptors under study. GDEE also reversibly blocked the effects of excitatory amino acids (L-glutamate and L-aspartate). The results suggest that L-glutamate or related substance is likely to be the synaptic transmitter in the ampullae of Lorenzini.
D000818:Animals; D001224:Aspartic Acid / Q000037:antagonists & inhibitors; D003864:Depression, Chemical; D004555:Electric Fish / Q000502:physiology*; D004560:Electricity; D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D066298:In Vitro Techniques; D012679:Sense Organs / Q000187:drug effects*; D011984:Sensory Receptor Cells / Q000187:drug effects*; D012860:Skates, Fish / Q000502:physiology*; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates; C011829:glutamic acid diethyl ester; D001224:Aspartic Acid; D018698:Glutamic Acid
Analiz vliianiia diétilovogo éfira glutaminovoĭ kisloty na sinapticheskie protsessy v ampulakh Lorentsini skatov.