title: X-linked retinoschisis is closely linked to DXS41 and DXS16 but not DXS85.
abstract: A linkage study was carried out in nine families with 24 males affected by X-linked recessive retinoschisis (RS), using three polymorphic DNA probes from the distal segment of Xp. Close linkage of the disease locus with markers DXS41 (probe p99-6) and DXS16 (pXUT23) was found, confirming the location of the RS gene on the distal short arm of the X chromosome. Lod scores for linkage with DXS85 (probe 782) were negative.
mesh_terms: D005808:Genes, Recessive; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D012167:Retinal Perforations / Q000235:genetics*; D014960:X Chromosome
chemical_list: D005819:Genetic Markers