Evidence that in vitro adherence of Klebsiella pneumoniae to ciliated hamster tracheal cells is mediated by type 1 fimbriae.
Clinical isolates of fimbriated and nonfimbriated Klebsiella pneumoniae were examined for the ability to adhere to hamster tracheal cells cultured in vitro. Fimbriated-phase K. pneumoniae adhered preferentially to ciliated cells, whereas nonfimbriated-phase organisms were not adherent. The adherence was inhibited by D-mannose but not D-glucose, suggesting that type 1 fimbriae serve as the adhesin in the attachment process.
D000818:Animals; D001422:Bacterial Adhesion; D006224:Cricetinae; D010861:Fimbriae, Bacterial / Q000502:physiology*; D066298:In Vitro Techniques; D007711:Klebsiella pneumoniae / Q000472:pathogenicity* / Q000648:ultrastructure; D008854:Microscopy, Electron; D014132:Trachea / Q000382:microbiology*