Modulation of the flavin-containing monooxygenase in guinea pigs by ascorbic acid and food restriction.
Modulation of the flavin-containing monooxygenase (FMO) by varying the ascorbic acid and food intake was investigated. Hepatic activity of the FMO in ascorbic acid-deficient guinea pigs fed a restricted amount of diet which resulted in a 10-15% body weight loss, was 17% of that in animals fed restricted amounts of the adequate diet. FMO hepatic activity in ascorbic acid-supplemented guinea pigs on a food-restricted regimen was 176% of that found in animals fed the adequate diet ad libitum. This increase in activity was not related to stress. Alteration in the activity of this important drug-metabolizing enzyme system by a combination of ascorbic acid deficiency and reduced food intake could potentially alter the rate of metabolism of a great variety of pharmaceutical drugs and environmental chemicals.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001206:Ascorbic Acid Deficiency / Q000201:enzymology*; D005508:Food Deprivation / Q000502:physiology*; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010105:Oxygenases / Q000378:metabolism*; D014444:Tyrosine Transaminase / Q000378:metabolism
D010105:Oxygenases; C020066:dimethylaniline monooxygenase (N-oxide forming); D014444:Tyrosine Transaminase; D001205:Ascorbic Acid