Screening for cryptorchid boys risking sterility and results of long-term buserelin treatment after successful orchiopexy.
This long-term prospective follow-up study showed that in cryptorchid patients a significant correlation exists between the number of germ cells at the time of orchiopexy (prepuberty) and the spermiogram, and thus a biopsy has a prognostic value. Fifty percent of our patients had a germ cell count of less than 0.1 per tubule and belong to the risk group for sterility. Successful surgery could not induce a significant increase of germ cells in the risk group, although it does prevent secondary testicular damage. Patients with cryptorchidism developed after birth have significantly better chances of fertility than those with primary cryptorchidism. The priming effect of testosterone in the first months of life is important for male fertility. In patients belonging to the risk group treated with buserelin, a significant age-dependent increase in germ cell count occurred.
D000328:Adult; D001706:Biopsy; D002064:Buserelin / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003456:Cryptorchidism / Q000473:pathology* / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D007248:Infertility, Male / Q000517:prevention & control*; D008297:Male; D013094:Spermatozoa / Q000473:pathology; D013737:Testis / Q000473:pathology*; D013997:Time Factors
D002064:Buserelin