title: Metastatic pheochromocytoma in pregnancy and fetal biophysical assessment after maternal administration of alpha-adrenergic, beta-adrenergic, and dopamine antagonists.
abstract: Metastatic pheochromocytoma, a rare complication of pregnancy, was managed from 30 weeks' gestation until delivery three weeks later with a combination of alpha-adrenergic blockade (Minipres) beta-adrenergic blockade (Timolol), and dopamine synthesis inhibition (Demser). The biophysical parameters of fetal heart rate (FHR) baseline, variability, and reactivity, as well as fetal breathing movements, body movements, tone, and amniotic fluid volume were followed sequentially during this period. A 1450-g growth-retarded infant, who subsequently did well, was delivered by cesarean section; the mother received combined surgical and medical therapy for her metastatic disease in the postpartum period. The initial fetal biophysical alteration observed was a reduction in mean FHR baseline rate; further biophysical test abnormalities appeared only after overt fetal compromise was evident. Sequential multiple parameter biophysical testing in such circumstances appears to be a valid and valuable approach to antepartum management.
mesh_terms: D000328:Adult; D002395:Catecholamines / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D005318:Fetal Heart / Q000187:drug effects; D005323:Fetal Monitoring; D005333:Fetus / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008781:Methyltyrosines / Q000627:therapeutic use; D010673:Pheochromocytoma / Q000188:drug therapy* / Q000556:secondary; D011224:Prazosin / Q000627:therapeutic use; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D013565:Sympatholytics / Q000009:adverse effects / Q000627:therapeutic use*; D013999:Timolol / Q000627:therapeutic use; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors; D019805:alpha-Methyltyrosine
chemical_list: D002395:Catecholamines; D008781:Methyltyrosines; D013565:Sympatholytics; D019805:alpha-Methyltyrosine; D013999:Timolol; D014446:Tyrosine 3-Monooxygenase; D011224:Prazosin