Rat brain microvessel extracellular matrix modulates the phenotype of cultured rat type 1 astroglia.
Astroglia from immature rat cerebral white matter which were plated on the insoluble extracellular matrix (ECM) secreted by rat cerebral microvessel endothelial cells (RCMEC) and maintained in a defined medium were induced to become stellate and to express glutamine synthetase. These effects were not elicited by RCMEC-conditioned medium. ECM secreted by rat pleural mesothelium elicited a lesser proportion of stellate astroglia and did not induce glutamine synthetase.
D000818:Animals; D001253:Astrocytes / Q000032:analysis / Q000201:enzymology / Q000502:physiology*; D001921:Brain / Q000098:blood supply*; D002454:Cell Differentiation; D002478:Cells, Cultured; D003337:Corpus Callosum / Q000166:cytology*; D004727:Endothelium / Q000378:metabolism; D005109:Extracellular Matrix / Q000502:physiology*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism; D008833:Microcirculation / Q000378:metabolism; D010641:Phenotype; D051381:Rats; D011919:Rats, Inbred Strains
D005904:Glial Fibrillary Acidic Protein; D005974:Glutamate-Ammonia Ligase