Somatostatin secretion in cultured human islet cells from patients with nesidioblastosis: a compensatory mechanism?
Two patients with nesidioblastosis, one with persistent hypoglycemia and another who was asymptomatic, underwent pancreatic resection. Dispersed pancreatic islets were prepared from each patient. Insulin secretion from cultured islet cells was increased and somatostatin decreased in the symptomatic patient compared with the asymptomatic patient. Immunocytochemistry showed increased somatostatin-containing cells in the asymptomatic patient. We hypothesize that this may be the mechanism by which some patients with nesidioblastosis maintain normal serum glucose levels.
D002469:Cell Separation; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism* / Q000473:pathology; D010179:Pancreas / Q000166:cytology / Q000378:metabolism / Q000601:surgery; D010182:Pancreatic Diseases / Q000378:metabolism* / Q000473:pathology; D013004:Somatostatin / Q000378:metabolism*
D007328:Insulin; D013004:Somatostatin