Huntington's disease: effect of cysteamine, a somatostatin-depleting agent.
Somatostatin levels in the basal ganglia are elevated in Huntington's disease. A controlled therapeutic trial of the somatostatin-depleting agent, cysteamine, was therefore conducted in five patients, including one with the rigid-akinetic form. Maximum tolerated dosage for 2 weeks produced no consistent change in extrapyramidal or dementia scores. Somatostatin concentrations were not significantly altered in plasma or CSF. Growth hormone levels, on the other hand, more than doubled, suggesting a functionally significant decrease in central somatostatin levels.
D000328:Adult; D003071:Cognition / Q000187:drug effects; D003543:Cysteamine / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013004:Somatostatin / Q000032:analysis*
D013004:Somatostatin; D003543:Cysteamine