Unloaded polyisobutylcyanoacrylate nanoparticles: efficiency against bloodstream trypanosomes.
The potential use of polyisobutylcyanoacrylate nanoparticles in antiparasitic chemotherapy is described. The nanoparticles on their own proved to have trypanocidal activity against Trypanosoma brucei brucei in-vitro but not against Trichomonas vaginalis or Entamoeba histolytica. The trypanocidal activity was partly confirmed in-vivo with T. brucei-infected mice.
D000818:Animals; D003487:Cyanoacrylates / Q000494:pharmacology / Q000627:therapeutic use*; D004659:Enbucrilate; D051379:Mice; D008863:Microspheres; D010316:Particle Size; D011108:Polymers; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D014353:Trypanosomiasis, African / Q000188:drug therapy*
D003487:Cyanoacrylates; D011108:Polymers; D004659:Enbucrilate