title: [Changes in neurohumoral factors of various tissues in patients with breast cancer].
abstract: Such neurohumoral factors of antitumor resistance regulation as catecholamines, corticosteroids and cholinergic mechanisms were studied in tissues of breast cancer patients. Tissue adjacent to tumor revealed elevated concentrations of 11-hydroxycorticosteroids and adrenaline matched by an increased release of norepinephrine which greatly depended on weakened cholinergic influences. These disturbances were pronounced in stages I and II tumors and, particularly, in infiltrating scirrhous cancer. Disbalance in neurohumoral factor distribution between normal and altered tissues may boost tumor recurrence and metastatic spread.
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000502:physiology*; D014018:Tissue Distribution
chemical_list: D018377:Neurotransmitter Agents
vernacular_title: Izmeneniia nekotorykh tkanevykh neĭrogumoral'nykh faktorov u bol'nykh rakom molochnoĭ zhelezy.