Inhibition of thromboxane biosynthesis by 3-pyridinol carboxypentyl ethers substituted with a hydroxylated octyl chain.
Racemic 6-[4-(3'-hydroxy-1'-octenyl)-3-pyridyloxy]hexanoic and 6-[4-(3'-hydroxyoctyl)-3-pyridyloxy] exanoic acids have been synthesized and their activity as inhibitors of the biosynthesis of thromboxane A2 in human serum has been studied, in comparison with isomers having the eight-carbon chain in the 2 position. Very high, selective activity was found for the new 4-substituted 3-pyridinol ethers, whereas the 2-substituted compounds showed no action.
D003864:Depression, Chemical; D015232:Dinoprostone; D006801:Humans; D011458:Prostaglandins E / Q000096:biosynthesis; D011725:Pyridines / Q000494:pharmacology*; D013929:Thromboxane B2 / Q000096:biosynthesis*; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D011458:Prostaglandins E; D011725:Pyridines; D013929:Thromboxane B2; D013930:Thromboxane-A Synthase; D015232:Dinoprostone