Somatostatinergic projections from the amygdala to the bed nucleus of the stria terminalis and medial preoptic-hypothalamic region.
Somatostatinergic projections of the amygdala to the bed nucleus of the stria terminalis (BST) and medial preoptic-hypothalamic region were examined using a technique that combines retrograde axonal transport with peroxidase-antiperoxidase immunohistochemistry. With injections of wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) into either the BST or medial preoptic-hypothalamic region numerous double-labeled cells exhibiting both retrograde labeling and somatostatin-like immunoreactivity were observed in the medial amygdaloid nucleus and intra-amygdaloid portion of the BST. Additional cells were seen in the central nucleus, basomedial nucleus and anterior amygdaloid area. Although WGA-HRP labeled neurons and somatostatin-positive cells were observed in the lateral and basolateral amygdaloid nuclei, few double-labeled neurons were found.
D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D007031:Hypothalamus / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D008032:Limbic System / Q000378:metabolism*; D008297:Male; D009434:Neural Pathways / Q000378:metabolism; D011301:Preoptic Area / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000378:metabolism*
D013004:Somatostatin