[GABA metabolism and the formation of a sensorimotor cortex evoked potential in the presence of excess zinc ions].
Changes in GABA content, the enzymatic activity of its metabolism and the formation of sensorimotor cortical evoked potential (EP) were studied following long-term ZnCl2 administration. It has been established that a single ZnCl2 injection at a dose of 0.1 and 1 mg/kg was accompanied by an increase in the amplitude of sensorimotor cortical EP, though GABA accumulation in this brain structure was observed. This might account for the prolongation of the period of the potential appearance. Long-term (for 7, 14, 21 days) ZnCl2 administration at a dose of 0.1 mg/kg produced a sharp depression in the potential appearance and an increase in GABA content by 50% with the enhancement of glutamate decarboxylase activity and the attenuation of GABA-transaminase activity.
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D002712:Chlorides / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005968:Glutamate Decarboxylase / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D013997:Time Factors; D015032:Zinc / Q000008:administration & dosage*; D017967:Zinc Compounds; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D002712:Chlorides; D005971:Glutamates; D017967:Zinc Compounds; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; C016837:zinc chloride; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase; D015032:Zinc
Obmen GAMK i formirovanie vyzvannogo potentsiala sensomotornoĭ kory na fone izbytka ionov tsinka.