title: Endogenous opioids, opiate receptors and traumatic brain injury.
abstract: The present study examined the role of endogenous opioid peptides in the pathophysiological sequelae of fluid percussion head injury in the cat. Two hours following injury, tissue concentrations of dynorphin-like immunoreactive material (ir-Dyn) were significantly elevated in specific brain regions where injury, as evidenced by histological examination, was most severe. Changes in ir-Dyn but not beta-endorphin-like immunoreactive material (ir-End) were significantly correlated with a fall in regional cerebral blood flow (CBF) that occurred 2 h following injury. Administration of the opiate antagonist WIN44,441-3 (with enhanced activity at kappa-receptors) stereospecifically increased cerebral blood flow to the injured regions.
mesh_terms: D000818:Animals; D001392:Azocines / Q000494:pharmacology; D001923:Brain Chemistry; D001930:Brain Injuries / Q000503:physiopathology*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004399:Dynorphins / Q000032:analysis*; D005260:Female; D008297:Male; D009292:Narcotic Antagonists / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D001615:beta-Endorphin / Q000032:analysis*
chemical_list: D001392:Azocines; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D001615:beta-Endorphin; D004399:Dynorphins; C035969:quadazocine