Pulmonary aerosol actions of LY188695 (KB2413), a new potent H1-receptor antagonist.
The new potent H1 receptor antagonist, LY188695 (KB2413), was delivered to guinea pigs as a pulmonary aerosol and its ability to inhibit histamine-induced airway obstruction examined. Aerosol LY188695 was more effective than inhaled chlorpheniramine or clemastine in reducing the pulmonary gas trapping produced by histamine challenge. Lung antihistamine effects occurred within minutes of a brief, low concentration aerosol exposure and persisted for at least 1 hour. LY188695 aerosol treatment did not produce significant inhibition of methacholine-induced gas trapping. Although systemic antihistamine effects occurred 50 minutes after LY188695 inhalation, aerosol administration produced an enhanced local (i.e., lung) action compared to intravenous delivery.
D000336:Aerosols; D000402:Airway Obstruction / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001985:Bronchial Provocation Tests; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002744:Chlorpheniramine / Q000627:therapeutic use; D002974:Clemastine / Q000627:therapeutic use; D006168:Guinea Pigs; D006632:Histamine / Q000633:toxicity; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007275:Injections, Intravenous; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000633:toxicity
D000336:Aerosols; D001562:Benzimidazoles; D001993:Bronchodilator Agents; D006634:Histamine H1 Antagonists; D008688:Methacholine Compounds; D016210:Methacholine Chloride; D002744:Chlorpheniramine; D001285:Atropine; D006632:Histamine; D002974:Clemastine; C043345:emedastine