title: [Risk of contrast medium reactions in cardiac diagnosis. Pretreatment with glucocorticoids and antihistaminics in known cases of intolerance to contrast media].
abstract: Among 4178 patients who between 1980 and 1986 had undergone left-heart catheterization with left-heart injections and coronary angiography there were 76 (1.8%) with previous reactions to contrast media. These latter patients were given, three days before the planned investigation, 6 alpha-methylprednisolone, 24 mg daily by mouth, and phenhydramine hydrogenmaleinate, 150 mg daily, and two hours before the investigation 80 mg 6 alpha-methylprednisolone hemisuccinate intravenously. The effect of this prophylactic regimen was tested prospectively. Diatrizoate 76% was the contrast medium used. Of 4102 patients without known contrast-medium intolerance 137 (3.34%) had a reaction, 27 of them (0.66%) severe enough to require treatment. Among the 76 patients with known previous reactions, nine (11.8%) had reactions, one very severe requiring treatment, the others mild. The described pre-injection regimen thus allows indicated left-heart contrast-medium injection to be undertaken at a justifiable risk.
mesh_terms: D006328:Cardiac Catheterization; D003287:Contrast Media / Q000276:immunology*; D017023:Coronary Angiography; D003973:Diatrizoate / Q000276:immunology; D004342:Drug Hypersensitivity / Q000517:prevention & control*; D005938:Glucocorticoids / Q000008:administration & dosage*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage*; D006801:Humans; D011292:Premedication; D012306:Risk
chemical_list: D003287:Contrast Media; D005938:Glucocorticoids; D006634:Histamine H1 Antagonists; D003973:Diatrizoate
vernacular_title: Risiko von Kontrastmittelreaktionen in der Herzdiagnostik. Vorbehandlung mit Glucocorticoiden und Antihistaminika bei bekannter Kontrastmittelunverträglichkeit.