[Tyrosine inhibition of anaphylactic shock in guinea pigs].
Experimental investigations on guinea-pigs were carried out to study the role of tyrosine in the prevention of anaphylaxis. It should be noted that the intensity of clinical manifestations of anaphylactic shock was reduced in 5 out of 24 L-tyrosine fed guinea-pigs (20.83%), while in 9 animals (37.5%) anaphylactic shock did not develop. 100% death of control animals was registered. The effect of tyrosine was absent only in 10 guinea-pigs. Positive effect of tyrosine was followed by tyrosine-aminotransferase activation with a tendency towards the decrease in tyrosine plasma level and the rise in cortisol blood level. It is suggested that tyrosine increases glucocorticoid secretion of the adrenal cortex: Glucocorticoids in their turn, enhance tyrosine-aminotransferase activity in the animal liver.
D000707:Anaphylaxis / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000097:blood; D007114:Immunization; D008099:Liver / Q000201:enzymology; D008297:Male; D014443:Tyrosine / Q000097:blood / Q000627:therapeutic use*; D014444:Tyrosine Transaminase / Q000378:metabolism
D014443:Tyrosine; D014444:Tyrosine Transaminase; D006854:Hydrocortisone
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