[Spontaneous development of paralysis induced by equipotent doses of vecuronium, atracurium, fazadinium, pancuronium, gallamine and d-tubocurarine].
Thirty-six patients undergoing elective surgery were studied after obtaining their informed consent. They were randomly assigned to six series of six patients each. One hour before anaesthesia, all patients received 0.2 mg.kg-1 diazepam orally. After induction of anaesthesia with 1-1.5 mg.kg-1 methohexitone and 5 micrograms.kg-1 fentanyl, the patients were paralysed and ventilation was controlled manually (semi-open circuit; 50% N2O/50% O2). Each patient received a single dose of either 70 micrograms.kg-1 fazadinium, 70 micrograms.kg-1 pancuronium, 2,500 micrograms.kg-1 gallamine or 450 micrograms.kg-1 d-tubocurarine. Neuromuscular function was monitored by measuring the isometric contraction of the adductor pollicis muscle in response to supramaximal stimulations of the ulnar nerve at the wrist (square wave pulse of 0.2 ms duration at supramaximal intensity delivery at 0.1 Hz). Three parameters were measured: the time between the injection of the relaxant drug and recovery of the twitch height at 50% of its baseline (RT0-50); the time between the injection of the relaxant drug and recovery of the twitch height at 90% of its baseline (RT0-90); the time between the injection of the relaxant drug and recovery of the twitch height from 25 to 75% of its baseline (RT25-75). The values of the observed parameters were expressed in minutes (means +/- SEM).(ABSTRACT TRUNCATED AT 250 WORDS)
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001279:Atracurium; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004576:Electromyography; D005703:Gallamine Triethiodide; D006801:Humans; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents; D009469:Neuromuscular Junction / Q000187:drug effects*; D010197:Pancuronium; D011726:Pyridinium Compounds; D011897:Random Allocation; D014403:Tubocurarine; D014673:Vecuronium Bromide
D009466:Neuromuscular Blocking Agents; D011726:Pyridinium Compounds; D001279:Atracurium; D014673:Vecuronium Bromide; D010197:Pancuronium; D005703:Gallamine Triethiodide; D014403:Tubocurarine
Evolution spontanée de la paralysie obtenue par des doses équipotentes de vécuronium, atracurium, fazadinium, pancuronium, gallamine et d-tubocurarine.