An alteration in the liver microsomal membrane of the rat following paracetamol overdose.
Fluorescence polarization of dansyl chloride covalently labelled microsomal membranes revealed an alteration in rat liver microsomal membranes following as a consequence of a paracetamol overdose. This suggests that dansyl chloride would be a useful probe in the study of the effects of paracetamol on microsomal membranes.
D000082:Acetaminophen / Q000506:poisoning*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005456:Fluorescent Dyes; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D051381:Rats
D005456:Fluorescent Dyes; D000082:Acetaminophen; D003577:Cytochrome P-450 Enzyme System; D001219:Aspartate Aminotransferases