Differential effects of competitive benzodiazepine receptor antagonists on the anticonflict activity of Gö 4962.
The anticonflict activity of the triazolobenzothiadiazine Gö 4962 (40 mg/kg po) in the four-plate test using male NMRI mice was selectively antagonized by beta CCE (10 mg/kg iv), but not by Ro 15-1788 (20 mg/kg ip) or CGS 8216 (20 mg/kg ip), although Gö 4962 has affinity for the benzodiazepine receptor. In contrast, the anticonflict activity of diazepam (4 mg/kg po) was antagonized by all three BZ antagonists. Relative to known putative anxiolytics, this profile of Gö 4962 is unexpected and unique.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects*; D001362:Avoidance Learning / Q000187:drug effects; D001581:Benzothiadiazines / Q000494:pharmacology*; D001667:Binding, Competitive / Q000187:drug effects; D003220:Conflict, Psychological; D003975:Diazepam / Q000494:pharmacology; D051379:Mice; D011963:Receptors, GABA-A / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D001581:Benzothiadiazines; D011963:Receptors, GABA-A; C053064:Goe 4962; D003975:Diazepam