The metabolic fate of camazepam in rats.
The metabolites of camazepam in rat plasma were characterized by t.l.c., mass spectroscopy and n.m.r. spectroscopy as the mono- or di-desmethylated metabolites and the mono- or di-hydroxymethylated metabolites. The postulated metabolic pathways of camazepam involved stepwise series of desmethylations. The mono- and di-hydroxymethylated metabolites were found to be intermediates in desmethylation. Temazepam and oxazepam, metabolites of camazepam, were formed from the mono- or di-hydroxymethylated metabolites.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D008745:Methylation; D010076:Oxazepam / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013693:Temazepam / Q000378:metabolism*
D014151:Anti-Anxiety Agents; D010076:Oxazepam; D013693:Temazepam