The neurotoxicology of lead.
In the past six years, our research group has investigated the relationship between lead exposure and mental and behavioural development. This has been carried out through studies in children and animals. Earlier studies in children have shown that associations might be expected between environmental exposure to lead and various aspects of cognitive and behavioural development. Our study has examined and continues to examine, a cohort of children sub-divided into three groups according to the level of lead exposure during early 'in utero' development. Data amassed to date includes measurement of psychometric function and post natal development, together with biochemical measures of lead exposure. Assessment will continue through to early scholastic performance and will include measurement of deciduous tooth lead concentration as an integrated measure of long term exposure. In addition to these studies in children, a series of neurochemical studies have been carried out using a rat model of lead exposure. Data obtained from both our own neurochemical experiments and those of other groups indicate an extremely complex plethora of neurotoxic actions of lead.
D000596:Amino Acids / Q000378:metabolism; D000622:Aminolevulinic Acid / Q000378:metabolism; D000818:Animals; D001708:Biopterins / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002648:Child; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D007854:Lead / Q000633:toxicity*; D007855:Lead Poisoning / Q000503:physiopathology*; D009420:Nervous System / Q000187:drug effects*; D009638:Norepinephrine / Q000378:metabolism; D011446:Prospective Studies; D014364:Tryptophan / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000596:Amino Acids; D001708:Biopterins; D007854:Lead; D005680:gamma-Aminobutyric Acid; D000622:Aminolevulinic Acid; D014364:Tryptophan; D014446:Tyrosine 3-Monooxygenase; C003402:sapropterin; D009638:Norepinephrine