Effect of mifentidine on mepirizole-induced duodenal ulcer in the rat.
The H2-receptor antagonists mifentidine, famotidine, cimetidine and ranitidine were examined for their ability to prevent the duodenal ulcer caused by mepirizole (250 mg/kg p.o.), a non-steroidal anti-inflammatory agent, in the conscious rat. All the compounds exerted a dose-related protective effect and on the basis of their ED50s, the following rank order of potency was found: mifentidine = famotidine greater than ranitidine greater than cimetidine. The antiulcer activity displayed by the H2-receptor antagonists evaluated in this model reflects their potency in inhibiting basal and stimulated gastric acid secretion in rat. The results of these studies indicate mifentidine as a potent anti-ulcer agent.
D000818:Animals; D000897:Anti-Ulcer Agents; D002927:Cimetidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D004386:Duodenum / Q000473:pathology; D004840:Epirizole / Q000037:antagonists & inhibitors*; D015738:Famotidine; D005260:Female; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000473:pathology; D011720:Pyrazoles / Q000037:antagonists & inhibitors*; D011899:Ranitidine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013844:Thiazoles / Q000494:pharmacology
D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D007093:Imidazoles; D011720:Pyrazoles; D013844:Thiazoles; C039796:mifentidine; D004840:Epirizole; D015738:Famotidine; D002927:Cimetidine; D011899:Ranitidine