Therapeutic results in cryptorchidism after combination therapy with LH-RH nasal spray and hCG.
Seventy-two boys with 81 cryptorchid testes were treated with combined LH-RH nasal spray and hCG in the period between 1983 and 1985. Cryptocur (LH-RH) was applied as nasal spray at a dose of 1.2 mg daily over a period of 14 days. In all of the patients, hCG treatment was carried out subsequently according to the WHO guidelines with five intramuscular injections at 2-day intervals. Primary treatment results considerably improved using the regimen. The rate of complete descent was 86.4% at the end of therapy and later dropped to 70.6% after 2 years follow-up. These results support the experience of Hadziselimovic et al. with this combined treatment.
D000281:Administration, Intranasal; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000627:therapeutic use*; D003456:Cryptorchidism / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male
D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone