Calcitonin gene-related peptide: enteric and cardiovascular effects in the dog.
We have measured the effects of intravenous infusion of calcitonin gene-related peptide at doses of 2.5, 10, and 50 pmol/kg.min on net jejunal water and solute fluxes and on plasma somatostatin concentrations in dogs. The hemodynamic effects and the pharmacokinetics of the peptide were also assessed. Using the triple-lumen perfusion technique in unsedated restrained animals it was shown that the highest dose of the peptide stimulated a transient net jejunal water and electrolyte secretion, and induced diarrhea in 4 of 6 animals receiving it. The peptide also induced dose-dependent tachycardia, hypotension, and increases in plasma immunoreactive somatostatin. All three doses of calcitonin gene-related peptide produced plasma immunoreactive peptide levels within the elevated range previously measured in human patients with medullary thyroid carcinoma. Calcitonin gene-related peptide may have a major role in the pathogenesis of secretory diarrhea in medullary thyroid carcinoma.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001834:Body Water / Q000378:metabolism*; D015740:Calcitonin Gene-Related Peptide; D004285:Dogs; D004573:Electrolytes / Q000378:metabolism*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D009479:Neuropeptides / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D011863:Radioimmunoassay; D013004:Somatostatin / Q000097:blood
D004573:Electrolytes; D009479:Neuropeptides; D013004:Somatostatin; D015740:Calcitonin Gene-Related Peptide