title: [Evaluation of the immunotoxicity of sulfanilamide, anti-inflammatory and antihistaminic preparations].
abstract: The effects of 15 widely used drugs on the production of IgE-antibodies and the development of anaphylactic sensitization of rat skin were studied. Some drugs were shown to be able to increasing antibody titres in the blood and prolonging skin sensitization.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000633:toxicity*; D004342:Drug Hypersensitivity / Q000209:etiology / Q000276:immunology; D006634:Histamine H1 Antagonists / Q000633:toxicity*; D007109:Immunity / Q000187:drug effects*; D007114:Immunization; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects / Q000276:immunology; D013424:Sulfanilamides / Q000633:toxicity*; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D006634:Histamine H1 Antagonists; D013424:Sulfanilamides; D007073:Immunoglobulin E
vernacular_title: K otsenke immunotoksichnosti nekotorykh sul'fanilamidnykh, protivovospalitel'nykh i protivogistaminnykh preparatov.