title: FMRFamide-like immunoreactivity and arylamidase activity in turbellarians and nemerteans--evidence for a novel neurovascular coordinating system in nemerteans.
abstract: The tetrapeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) has been immunolocalized in the nervous systems of seven species of Turbellaria and four species of Nemertea. The 11 species represent all the major turbellarian and nemertean taxa, and illustrate most of the various life styles found in these animals. The FMRFamide-like reactivity coincides with histochemically demonstrable arylamidase activity in the nervous systems. It is suggested that the FMRFamide-like reactivity demonstrates the presence in these lower invertebrates of one or more biologically active peptides, analogous to those of higher invertebrates and chordates and acting as putative neurotransmitters and coordinators of growth, maturation and muscular activities. The arylamidases occurring with the peptides are probably an integral part of these peptide-mediated control systems. The nemertean vascular system is especially rich in arylamidases and is believed to be concerned primarily with peptidergic control of bodily functions, rather than with transport of metabolites.
mesh_terms: D000626:Aminopeptidases / Q000502:physiology; D000818:Animals; D019835:FMRFamide; D007158:Immunologic Techniques; D007448:Invertebrates / Q000502:physiology*; D009424:Nervous System Physiological Phenomena; D009479:Neuropeptides / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology; D014419:Turbellaria / Q000502:physiology*
chemical_list: D009479:Neuropeptides; D018377:Neurotransmitter Agents; D019835:FMRFamide; D000626:Aminopeptidases