title: Do young patients with dyspepsia need investigation?
abstract: During 1986, 1386 patients with simple dyspepsia were referred by general practitioners for endoscopy (686) or double-contrast barium meal examination (700) at Leicester General Hospital. 618 (45%) were under the age of 45 years. Abnormal findings were more common in older than younger dyspeptic patients (58% vs 40% at endoscopy, 69% vs 25% by barium meal). Malignant disorders were diagnosed in 5% at endoscopy and 3% at barium meal, but in no patient under 45 years old. The incidence of malignant disorders at endoscopy was analysed for the 6 years 1980-86. Of 707 cases identified, only 13 (1.8%) occurred in patients under 45 years old; all 13 had symptoms suggesting pathology more serious than simple dyspepsia. It can be concluded that young patients with simple dyspepsia are overinvestigated. A majority can be treated safely with antacids and/or histamine receptor type 2 antagonists.
mesh_terms: D000328:Adult; D000367:Age Factors; D000863:Antacids / Q000627:therapeutic use; D001466:Barium Sulfate; D004415:Dyspepsia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005773:Gastroscopy / Q000706:statistics & numerical data*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011859:Radiography; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging
chemical_list: D000863:Antacids; D006635:Histamine H2 Antagonists; D001466:Barium Sulfate