Responsiveness of isolated monkey coronary arteries contracted with alpha 1- and alpha 2-adrenoceptor agonists to diltiazem.
Diltiazem induced a concentration-dependent relaxation of monkey coronary arterial strips which were partially contracted with clonidine, phenylephrine, norepinephrine, prostaglandin F2 alpha. This relaxation occurred to a similar extent, but was significantly less than that observed in arteries contracted with K+. Contractions mediated via alpha 2-adrenoceptors do not appear to be more susceptible to diltiazem than those caused by activation of alpha 1-adrenoceptors and prostaglandin F2 alpha receptors.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D003331:Coronary Vessels / Q000502:physiology*; D004110:Diltiazem / Q000494:pharmacology*; D015237:Dinoprost; D005260:Female; D066298:In Vitro Techniques; D008251:Macaca; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011188:Potassium / Q000494:pharmacology; D011460:Prostaglandins F / Q000378:metabolism; D011982:Receptors, Prostaglandin / Q000378:metabolism
D000316:Adrenergic alpha-Agonists; D011460:Prostaglandins F; D011982:Receptors, Prostaglandin; D015237:Dinoprost; D004110:Diltiazem; D003000:Clonidine; D011188:Potassium