Effect of a long-acting somatostatin analogue (SMS 201-995) on postprandial gastric emptying of 99mTc-tin colloid and mouth-to-caecum transit time in man.
The effect on gut motility of a single subcutaneous injection of 50 micrograms of the long-acting somatostatin analogue, SMS 201-995, was investigated in 8 normal volunteers who took a drink containing 99mTc and lactulose with a mixed meal. The rate of gastric emptying was assessed by disappearance of the isotope from the stomach area as measured by a gamma camera, and mouth-to-caecum transit time (MCTT) was measured by the appearance of hydrogen in the breath. Gastric emptying was accelerated, with a significant reduction of the time taken to 50% isotope disappearance (37.2 +/- 3.3 min during control study vs 23.3 +/- 3.4 min after SMS injection; p less than 0.01). In contrast, MCTT was prolonged from 57.3 +/- 9.4 min (control) to 203.6 +/- 14.7 min after SMS (p less than 0.001).
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001944:Breath Tests; D005746:Gastric Emptying / Q000187:drug effects; D005768:Gastrointestinal Hormones / Q000097:blood; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D006859:Hydrogen / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008297:Male; D015282:Octreotide; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000494:pharmacology; D013667:Technetium; D017556:Technetium Compounds; D014001:Tin; D017971:Tin Compounds
D001786:Blood Glucose; D005768:Gastrointestinal Hormones; D007328:Insulin; D017556:Technetium Compounds; D017971:Tin Compounds; C033493:technetium Tc 99m tin colloid; D013004:Somatostatin; D013667:Technetium; D014001:Tin; D006859:Hydrogen; D015282:Octreotide