Stimulation of expression of the human endogenous retrovirus genome by female steroid hormones in human breast cancer cell line T47D.
Expression of the human endogenous retrovirus genome HERV-K, homologous to mouse mammary tumor virus, was investigated in cultured human tumor cells. In several cell lines, the HERV-K genome was expressed as an 8.8-kilobase poly(A)+ RNA which appeared to be a full-size transcript of this genome. In the human breast cancer cell line T47D, stimulation of HERV-K genome expression by progesterone was observed after estradiol treatment.
D001943:Breast Neoplasms / Q000382:microbiology* / Q000473:pathology; D002460:Cell Line; D003907:Dexamethasone / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D011061:Poly A / Q000096:biosynthesis; D011374:Progesterone / Q000494:pharmacology*; D012333:RNA, Messenger / Q000096:biosynthesis; D012334:RNA, Neoplasm / Q000096:biosynthesis; D012367:RNA, Viral / Q000096:biosynthesis; D012190:Retroviridae / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic; D014775:Virus Activation / Q000187:drug effects*
D012333:RNA, Messenger; D012334:RNA, Neoplasm; D012367:RNA, Viral; D011061:Poly A; D011374:Progesterone; D004958:Estradiol; D003907:Dexamethasone