[Alkyl- and alkoxy-substituted lamtidine analogs: synthesis and H2-antagonistic activity. 38. H2-antihistaminics].
In studies on the structure-activity relationships of histamine H2-receptor antagonists, lamtidine analogous derivatives of ortho-, meta- und para-substituted piperidinomethylphenoxypropylamines bearing an additional substituent on the aromatic ring were prepared and tested for their H2-antagonistic activity on the isolated guinea-pig atrium. An additional substituent decreases the H2-antagonistic activity of the 3-(3-piperidinomethyl-phenoxy)-propylamine derivatives, while 2-membered substituents neighboring the connecting chain increase the activity of the ortho- and para-piperidinomethyl-substituted phenoxypropylamine derivatives.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006635:Histamine H2 Antagonists / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013055:Spectrophotometry, Infrared; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D006635:Histamine H2 Antagonists; D010880:Piperidines; D014230:Triazoles
Alkyl- und Alkoxy-substituierte Lamtidin-Analoge: Synthese und H2-antagonistische Aktivität. 38. Mitteilung: H2-Antihistaminika.