Acute effect of TRH, flunarizine, lithium and zotepine on amygdaloid kindled seizures induced with low-frequency stimulation.
We assessed the acute effects of various drugs on amygdaloid kindled seizures induced with low-frequency stimulations. We used the number of stimulating pulses required for the induction of epileptic afterdischarge (pulse-number threshold; PNT) as an indicator of the seizure generating threshold and the duration of induced seizures (AD duration; ADD) as an indicator of the seizures. TRH increased the PNT without affecting the ADD at a high dose (1.2 mg/kg). Flunarizine decreased the PNT and ADD simultaneously at a high dose (50 mg/kg). Lithium increased the PNT without affecting the ADD at two doses (100 mg/kg, 200 mg/kg). Zotepine decreased the PNT without affecting the ADD at two doses (8 mg/kg, 16 mg/kg). We propose that the technique of low-frequency kindling is a useful experimental model in assessing the effects of antipsychotic or antiepileptic drugs on the excitability of the limbic regions.
D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002415:Cats; D003988:Dibenzothiepins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D005444:Flunarizine / Q000494:pharmacology*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008094:Lithium / Q000494:pharmacology*; D016651:Lithium Carbonate; D008297:Male; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D014150:Antipsychotic Agents; D003988:Dibenzothiepins; D016651:Lithium Carbonate; D013973:Thyrotropin-Releasing Hormone; D008094:Lithium; D005444:Flunarizine; C022172:zotepine