Vecuronium--a variable dose technique.
Vecuronium was administered to patients in doses of 100, 150, 200 and 250 micrograms/kg and the duration of action recorded by noting the time to recovery of the first twitch in a train-of-four to 10% of the control twitch. The recovery times ranged from a mean of 28.4 minutes (100 micrograms/kg) to 72.4 minutes (250 micrograms/kg). It is suggested that for operations of medium to long duration the use of a large initial bolus dose of vecuronium is a technique with advantages over the use of an infusion or frequent incremental doses.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D013514:Surgical Procedures, Operative; D013997:Time Factors; D014673:Vecuronium Bromide / Q000008:administration & dosage* / Q000494:pharmacology
D014673:Vecuronium Bromide