Taste receptor mechanism of salts in frog and rat.
Salts carrying impermeable organic cations elicited large responses in the frog and rat taste nerves. Amiloride suppressed the responses of the frog and rat taste nerves to NaCl, KCl and the organic salts to a similar extent. The estimated equilibrium potentials for Na+ and K+ at the thresholds determined were more negative than the resting potentials of the taste cells. The results obtained suggest that the taste responses to salts including NaCl are not induced by entry of cations via apical membranes of taste cells.
D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D008297:Male; D008465:Mechanoreceptors / Q000187:drug effects / Q000502:physiology*; D011892:Rana catesbeiana; D051381:Rats; D011919:Rats, Inbred Strains; D012492:Salts; D013045:Species Specificity; D013649:Taste; D014059:Tongue / Q000187:drug effects / Q000502:physiology*
D012492:Salts; D000584:Amiloride