Prosomatostatin processing in anglerfish brain, gut and pancreas.
The distribution of somatostatin immunoreactive forms in three tissues of the anglerfish (Lophius piscatorius L.) was analyzed by a combination of gel permeation, High Pressure Liquid Chromatography and amino acid analysis. The data indicate that prosomatostatins I and II are expressed in both neural and gastro-intestinal tissues and that their post-translational processing gives rise to somatostatin-14 I, somatostatin-28 II and to some of its hydroxylysine23-derivative, respectively. It is concluded that, in contrast to the mammals, production of two somatostatins in the Teleostean fish requires two structurally distinct precursors whose processing operates in a fixed pattern rather than in a tissue-specific manner.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D004064:Digestive System / Q000378:metabolism*; D005399:Fishes / Q000378:metabolism*; D010179:Pancreas / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*; D013004:Somatostatin / Q000378:metabolism*; D014018:Tissue Distribution
D000596:Amino Acids; D011498:Protein Precursors; D013004:Somatostatin; C028456:prosomatostatin