HTLV-I-induced lymphoma mimicking Hodgkin's disease. Diagnosis by polymerase chain reaction amplification of specific HTLV-I sequences in tumor DNA.
A patient with a localized HTLV-I-associated lymphoproliferative disease that was misdiagnosed as Hodgkin's disease is presented. The patient's serum was negative for HTLV-I antibodies by enzyme-linked immunosorbent assay (ELISA), Western blot, and radioimmunoprecipitation. Tumor tissue DNA was negative for HTLV-I by Southern blotting but was positive for distinct HTLV-I sequences when subjected to DNA amplification using the polymerase chain reaction. We conclude that the clinical and pathologic diagnosis of HTLV-I-related lymphoma can be difficult and can be confused with Hodgkin's disease. Extremely sensitive molecular biological techniques may be required to establish a diagnosis of HTLV-I-induced lymphoma.
D000328:Adult; D001483:Base Sequence; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000235:genetics*; D004259:DNA-Directed DNA Polymerase / Q000235:genetics*; D017977:Deltaretrovirus / Q000235:genetics*; D006800:Deltaretrovirus Infections / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D003937:Diagnosis, Differential; D005784:Gene Amplification; D006689:Hodgkin Disease / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male
D004273:DNA, Neoplasm; D004259:DNA-Directed DNA Polymerase