The degradation of temocillin, a 6 alpha-methoxypenicillin, and identification of the major degradation products.
Temocillin, 6 beta-(R,S-2'-carboxy-2'-thien-3-ylacetamido)-6 alpha-methoxypenicillanic acid, shows good stability in mild aqueous acid or base; in stronger acid the methoxypenillic acid is formed whereas alkaline or enzyme hydrolysis results in the formation of the methoxypenicilloic acid and the C-5 epimer.
D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D010406:Penicillins
D010406:Penicillins; C031367:temocillin