title: An alteration in the liver microsomal membrane of the rat following paracetamol overdose.
abstract: Fluorescence polarization of dansyl chloride covalently labelled microsomal membranes revealed an alteration in rat liver microsomal membranes following as a consequence of a paracetamol overdose. This suggests that dansyl chloride would be a useful probe in the study of the effects of paracetamol on microsomal membranes.
mesh_terms: D000082:Acetaminophen / Q000506:poisoning*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005456:Fluorescent Dyes; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D051381:Rats
chemical_list: D005456:Fluorescent Dyes; D000082:Acetaminophen; D003577:Cytochrome P-450 Enzyme System; D001219:Aspartate Aminotransferases