Liver involvement in human schistosomiasis mansoni. Regression of immunological and biochemical disease markers after specific treatment.
Peripheral blood cholyglycine and procollagen-III-peptide were measured in 22 Zairean patients with hepatomegaly caused by S. mansoni before and after treatment with praziquantel. Circulating T-cell subsets and cutaneous in vivo delayed type hypersensitivity were assessed; serum neopterin and beta 2-microglobulin served as indicators for macrophage/lymphocyte activation. The results were compared to age and sex matched patients with S. mansoni infection limited to the intestinal tract and schistosomiasis free controls with equal socioeconomic background. Abnormal serum cholyglycine and neopterin levels and alterations of circulating T-cell subset frequencies were associated with hepatomegaly in schistosomiasis. Normalization of these parameters reflected a regression of egg-induced immunopathology as early as two months after specific chemotherapy. Serum procollagen-III-peptide concentrations rose significantly after treatment, suggesting release of propeptide previously incorporated without cleavage into tissue collagen. The combination of these biochemical and immunological parameters may allow assessment of the pathophysiological mechanisms responsible for liver disease in individual patients.
D000293:Adolescent; D000328:Adult; D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006000:Glycocholic Acid / Q000097:blood; D006529:Hepatomegaly; D006801:Humans; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007411:Intestinal Diseases, Parasitic / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D008109:Liver Diseases, Parasitic / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008875:Middle Aged; D019798:Neopterin; D010270:Parasite Egg Count; D010446:Peptide Fragments / Q000097:blood*; D011223:Praziquantel / Q000627:therapeutic use; D011347:Procollagen / Q000097:blood*; D012550:Schistosoma mansoni / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D013163:Splenomegaly; D013601:T-Lymphocytes / Q000145:classification; D001613:beta 2-Microglobulin / Q000032:analysis
D000909:Antibodies, Helminth; D010446:Peptide Fragments; D011347:Procollagen; D001613:beta 2-Microglobulin; C041876:procollagen Type III-N-terminal peptide; D001708:Biopterins; D011223:Praziquantel; D019798:Neopterin; D006000:Glycocholic Acid