Susceptibility of Bordetella pertussis to five quinolone antimicrobic drugs.
Five quinolone antimicrobic agents were tested to determine the mean inhibitory concentration (MIC) of each of 17 clinical strains of Bordetella pertussis by the agar dilution method. Ciprofloxacin demonstrated the best in vitro activity with an MIC90 of 0.06 microgram/ml. Norfloxacin, ofloxacin and enoxacin were also highly active with MIC90s of 0.25, 0.25, and 0.5, respectively. Cinoxacin was only moderately active (MIC90 4.0 microgram/ml).
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001886:Bordetella pertussis / Q000187:drug effects* / Q000302:isolation & purification; D002937:Cinoxacin / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D015365:Enoxacin; D006801:Humans; D009287:Naphthyridines / Q000494:pharmacology; D009643:Norfloxacin / Q000494:pharmacology; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology; D014917:Whooping Cough / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D009287:Naphthyridines; D010078:Oxazines; D015365:Enoxacin; D002939:Ciprofloxacin; D015242:Ofloxacin; D002937:Cinoxacin; D009643:Norfloxacin