Pathological and immunological observations on tropical spastic paraparesis in patients from Jamaica.
The neuropathological examination of the spinal cord of 2 Jamaican patients with classical tropical spastic paraparesis disclosed an intense chronic meningomyelitis with demyelination. In the 1 case in which serum and cerebrospinal fluid were available, antibodies to the human T-lymphotropic virus type 1 were found.
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis / Q000134:cerebrospinal fluid; D000914:Antibodies, Viral / Q000032:analysis / Q000134:cerebrospinal fluid; D001921:Brain / Q000473:pathology; D015480:Deltaretrovirus Antibodies; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007563:Jamaica; D009128:Muscle Spasticity / Q000276:immunology / Q000473:pathology; D010264:Paraplegia / Q000276:immunology / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology; D014330:Tropical Medicine
D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral; D015480:Deltaretrovirus Antibodies; D007074:Immunoglobulin G