title: Effect of somatostatin on human gastric blood flow evaluated by endoscopic laser Doppler flowmetry.
abstract: The effect of somatostatin on human gastric blood flow has been evaluated by endoscopic laser Doppler flowmetry. A bolus injection of 250 micrograms somatostatin intravenously caused a transitory decrease in the gastric blood flow of 40%. After continuous infusion of somatostatin for 1 h no change in the gastric microcirculation could be demonstrated in spite of significantly elevated somatostatin-like immunoreactivity in plasma. The results do not give evidence that somatostatin has a possible beneficial effect in patients with gastric bleeding caused by a significant gastric blood flow reduction.
mesh_terms: D000328:Adult; D005260:Female; D005773:Gastroscopy; D006801:Humans; D007834:Lasers; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D012212:Rheology; D013004:Somatostatin / Q000097:blood / Q000494:pharmacology*; D013270:Stomach / Q000098:blood supply*
chemical_list: D013004:Somatostatin