Capillary gas chromatographic-mass spectrometric study of the effect of solvents on metoprolol and other aryloxypropanolamines.
When metoprolol in methanol was analysed by capillary gas chromatography (GC), an additional peak was observed; mass spectrometry (MS) showed this additional peak to have a molecular weight 12 dalton higher than that of the parent compound. A similar phenomenon was observed with other beta-adrenergic blocking aryloxypropanolamines in methanol or dichloromethane. Capillary GC-MS using deuterated solvents as isotopic markers showed that a methylene group from the solvents was incorporated into the parent molecule. The structure of the observed products and the mechanism of their formation are proposed.
D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D008790:Metoprolol / Q000032:analysis*; D011412:Propanolamines / Q000032:analysis* / Q000302:isolation & purification; D012997:Solvents
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D012997:Solvents; D008790:Metoprolol