Neuroleptics and epilepsy in mentally handicapped patients.
A retrospective investigation of mentally handicapped inpatients showed that neuroleptic treatment did not precipitate fits in patients without a past history of convulsions when low to moderate dosages were used. However, neuroleptic treatment did increase the number of fits in certain patients with a history of epilepsy who were receiving inadequate anticonvulsant medication or whose fits were poorly controlled despite adequate anticonvulsant levels. Guidelines for clinical practice drawn from these findings are presented.
D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008607:Intellectual Disability / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D012189:Retrospective Studies
D000927:Anticonvulsants; D014150:Antipsychotic Agents