Enantiomer resolution of nefopam hydrochloride, a novel analgesic: a study by liquid chromatography and circular dichroism spectroscopy.
Nefopam, a potent analgesic, has been completely resolved into enantiomers on a preparative scale by low-pressure liquid chromatography on swollen, microcrystalline triacetylcellulose. The enantiomerically pure hydrochlorides were prepared from the base, and the circular dichroism spectra of the free base and the hydrochloride are reported.
D000700:Analgesics / Q000032:analysis; D002853:Chromatography, Liquid; D002942:Circular Dichroism; D009340:Nefopam / Q000032:analysis / Q000494:pharmacology*; D010079:Oxazocines / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D000700:Analgesics; D010079:Oxazocines; D009340:Nefopam