Na+ + K+-ATPase activity and transport processes in toad corneal epithelium.
1. Ascorbic acid, diamide and N-ethylmaleimide inhibit Na+ + K+-ATPase activity in toad corneal epithelium. 2. Ascorbic acid, diamide and N-ethylmaleimide increase alpha-aminoisobutyric acid accumulation in this tissue. 3. The effects of these compounds on corneal amino acid and ion transport are not mediated through alterations in Na+ + K+-ATPase activity.
D000621:Aminoisobutyric Acids / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D002024:Bufo marinus; D003315:Cornea / Q000378:metabolism*; D003683:Dehydroascorbic Acid / Q000494:pharmacology; D003958:Diamide / Q000494:pharmacology; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D005033:Ethylmaleimide / Q000494:pharmacology; D005978:Glutathione / Q000031:analogs & derivatives / Q000494:pharmacology; D019803:Glutathione Disulfide; D066298:In Vitro Techniques; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D000621:Aminoisobutyric Acids; D003958:Diamide; C100049:2-aminoisobutyric acid; D000254:Sodium-Potassium-Exchanging ATPase; D005978:Glutathione; D005033:Ethylmaleimide; D001205:Ascorbic Acid; D019803:Glutathione Disulfide; D003683:Dehydroascorbic Acid