Pathomorphologic characterization of CNS damage in monkeys infected with persistent variant of measles virus vaccine strain L-16.
The lesions of CNS were examined in monkeys infected intracerebrally (i.c.) with a variant of measles virus vaccine strain L-16 isolated after prolonged persistence in human cell culture NEr-2. The persisting virus variant appeared pathogenic for monkeys. The changes which had developed in their CNS within 30 to 60 days post-infection (p.i.) were alike to acute measles encephalitis which was evidenced by giant cell formation at the injection site. Twenty-two months p.i. the chronic character of lesions was evident from the appearance of foci of neuron destruction. Based on morphologic findings it was suggested that strain L-16-H has acquired some properties characteristic of nonattenuated virus.
D000818:Animals; D001921:Brain / Q000473:pathology*; D002460:Cell Line; D002522:Chlorocebus aethiops; D004660:Encephalitis / Q000382:microbiology* / Q000473:pathology; D008457:Measles / Q000382:microbiology* / Q000473:pathology; D008458:Measles Vaccine; D008459:Measles virus / Q000472:pathogenicity*; D013116:Spinal Cord / Q000473:pathology; D014709:Vero Cells
D008458:Measles Vaccine