title: Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man.
abstract: Antagonism of the effects of platelet activating factor (PAF) by the ginkgolide mixture BN 52063 was assessed in a double-blind, placebo-controlled, crossover study in 6 normal subjects. Weal and flare responses to 400 ng PAF, examined 2 h after ingestion of BN 52063 (80 mg, 120 mg) were inhibited in a dose-related manner. After 120 mg the flare area was reduced by a mean 62.4% (p less than 0.005) and the weal volume by a mean 60% (p less than 0.05). Both doses of BN 52063 significantly inhibited PAF-induced platelet aggregation in platelet-rich plasma (p less than 0.001). In vitro, BN 52063 inhibited PAF-induced but not ADP-induced platelet aggregation. Thus BN 52063 seems to be an antagonist of PAF in man.
mesh_terms: D000328:Adult; D002214:Capsules; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D066298:In Vitro Techniques; D007271:Injections, Intradermal; D007783:Lactones; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D010974:Platelet Aggregation / Q000187:drug effects*; D011897:Random Allocation; D012867:Skin / Q000187:drug effects*
chemical_list: D002214:Capsules; D007783:Lactones; D010936:Plant Extracts; D010972:Platelet Activating Factor; C050422:BN 52063