[Nuclear DNA fluorocytophotometric analysis of leukemic cells in adult T-cell leukemia/lymphomas (ATLL)].
The nuclear DNA content of the leukemic cells in six cases of ATLL and one of peripheral T-cell malignant lymphoma (PTML) were analyzed by fluorocytophotometry, simultaneously evaluating the nuclear shape and the longest nuclear axis (LNA). The leukemic cells, characterized by the nuclear shape and LNA, had a little hyperdiploid DNA content, and they belonged to GO/GI cells. The life span of the leukemic cells was suggested to be as short as two to three weeks or much longer than the survival time of the patients, evaluating the change of the LNA histogram under chemotherapy from the diagnosis up to the patients' death. One of the ATLLs, showing small leukemic cells and a clinical course of more than three years, might be a new entity, T-CLL-like ATLL.
D000328:Adult; D000368:Aged; D004273:DNA, Neoplasm / Q000032:analysis; D006800:Deltaretrovirus Infections / Q000097:blood*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000145:classification* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D004273:DNA, Neoplasm