title: Evidence for somatostatin-containing fibers projecting from the pallidal complex to the striatum of the rat.
abstract: The origin of afferent somatostatin-containing fibers terminating in medial and ventral parts of the striatum has been investigated by performing various neurochemical and surgical lesions in the rat. Lesions of the anterior hypothalamus, amygdala, and the hippocampal commissure as well as lesions with 6-hydroxydopamine and 5,7-dihydroxytryptamine failed to decrease striatal somatostatin levels. However, thermal coagulation of the globus pallidus or knife-cut lesions performed ventrally to the striatum resulted in significant decreases in striatal somatostatin content. Analysis of the topographical distribution of somatostatin within the striatum after thermal lesions of the globus pallidus as well as after kainic acid-induced seizures revealed a preferential loss of the peptide in medial and ventral portions of the striatum, the site of terminating afferent somatostatin nerve fibers. The data suggest that the striatal afferent somatostatin-containing neurons may originate in the area of the globus pallidus.
mesh_terms: D000679:Amygdala / Q000502:physiology; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D005917:Globus Pallidus / Q000378:metabolism* / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology; D008032:Limbic System / Q000502:physiology*; D008297:Male; D009434:Neural Pathways / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000378:metabolism*; D013004:Somatostatin / Q000378:metabolism*
chemical_list: D013004:Somatostatin