Effects of a preparation containing a standardized ginseng extract combined with trace elements and multivitamins against hepatotoxin-induced chronic liver disease in the elderly.
A preparation containing a standardized ginseng extract which has been shown to exert anti-hepatotoxic activity in vitro, combined with trace elements and multi-vitamins was compared to placebo in 24 elderly out-patients with toxin-induced (alcohol and drugs) chronic liver disease in order to evaluate its effect on liver function. Each patient was blindly treated either with the preparation containing ginseng extract or placebo for 12 weeks. The preparation containing ginseng extract significantly modified bromsulphthalein retention and blood zinc levels when compared to pre-treatment levels and to placebo. Serum bile acids, and gamma-glutamyl transpeptidase before and after a fatty meal were significantly reduced after treatment with the test preparation and not with placebo. When the two treatment groups were compared, however, no significant difference in these parameters was observed. These results suggest that treatment with the preparation containing ginseng extract could improve the detoxifying activity of the liver in elderly patients with toxin-induced chronic liver disease.
D000368:Aged; D001647:Bile Acids and Salts / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004041:Dietary Fats / Q000494:pharmacology; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D036145:Ginsenosides; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D008107:Liver Diseases / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D005894:Panax; D010946:Plants, Medicinal; D011897:Random Allocation; D012503:Saponins / Q000627:therapeutic use*; D014131:Trace Elements / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use*; D015032:Zinc / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D001647:Bile Acids and Salts; D004041:Dietary Fats; D036145:Ginsenosides; D012503:Saponins; D014131:Trace Elements; D014815:Vitamins; D005723:gamma-Glutamyltransferase; D015032:Zinc