Identification of human herpesvirus-6 as a causal agent for exanthem subitum.
A virus was isolated from the peripheral blood lymphocytes of patients with exanthem subitum, cultured successfully in cord blood lymphocytes, and shown to be antigenically related to human herpesvirus-6 (HHV-6). Morphological features, as studied by thin-section electronmicroscopy, resembled those of herpes group viruses. Convalescent-phase serum samples, tested against the new viral antigen and HHV-6 antigen, showed seroconversion. The results strongly suggest that the newly isolated virus is identical or closely related to HHV-6 and the causal agent for exanthem subitum.
D000208:Acute Disease; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D005077:Exanthema Subitum / Q000209:etiology / Q000276:immunology / Q000382:microbiology*; D006564:Herpesviridae / Q000145:classification / Q000302:isolation & purification* / Q000648:ultrastructure; D006566:Herpesviridae Infections; D006801:Humans; D007223:Infant; D008855:Microscopy, Electron, Scanning
D000914:Antibodies, Viral