Ultrastructural effects of cadmium on the epididymis of the cryptorchid rat.
The short-term (90 min) effect of an intraperitoneal injection of cadmium chloride (3 mumol/100 g body weight) was studied with the electron microscope in the epididymis of mature rats rendered unilaterally cryptorchid 60 days before injection. It was found that the endothelium of the epididymal capillaries of the cryptorchid organ, at this low dose and short time, showed neither separation of cytoplasmic leaflets, nor platelet damage, nor extravasation, which are the lesions previously described by us and which were present in the contralateral, scrotal epididymis. The possible mechanisms for the protective action of cryptorchidism against the effects of cadmium on capillary endothelia are discussed.
D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D002196:Capillaries / Q000187:drug effects / Q000648:ultrastructure; D003456:Cryptorchidism / Q000473:pathology*; D004727:Endothelium / Q000187:drug effects / Q000648:ultrastructure; D004822:Epididymis / Q000098:blood supply / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats
D002104:Cadmium