title: The effect of artificially induced hyperglycemia on the radiation response of the Lewis lung and EMT6 tumor models.
abstract: The effect of hyperglycemia, induced by administration of glucose, on the radiation response of the Lewis lung and EMT6 tumor models has been evaluated. Neither acute (single i.p. injection of 8 mg/glucose) nor chronic (multiple i.p. injections of 6 mg/g glucose plus glucose in the water bottles) administrations of glucose increased the radiation response of either tumor. A combination of a single i.p. injection of glucose and a reduction of the O2 content of the inspired gas to 10 per cent did by itself reduce cell survival by 55-75 per cent in the EMT6 and 80-90 per cent in the Lewis lung carcinoma. However, this treatment had little effect on the shape of the radiation dose-response curve, and simply gave rise to a parallel shift of the survival curve, indicating that this treatment had little or no specificity for hypoxic cells.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000502:physiology*; D002470:Cell Survival / Q000528:radiation effects; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000532:radiotherapy*
chemical_list: D001786:Blood Glucose