title: Thyrotrophin-releasing hormone-induced growth hormone secretion in ducks: independence of peripheral plasma somatostatin, insulin, and glucagon.
abstract: In young, but not old, ducks the iv infusion of thyrotrophin-releasing hormone (TRH) markedly increased peripheral plasma growth hormone (GH) concentrations, which remained elevated throughout the 30-min period of infusion. This GH response to TRH was suppressed by the simultaneous infusion of somatostatin, which increased the level of circulating somatostatin-like immunoreactivity (SLI) to supraphysiological levels. Basal concentrations of plasma SLI in both young and old birds were suppressed by TRH infusion. Concentrations of glucagon-like immunoreactivity (GLI) were increased by the infusion of TRH in young birds but not in adults, whereas plasma immunoreactive insulin (IRI) was decreased in young birds and increased in adults following TRH infusion. These results indicate that TRH-induced GH secretion in ducks is unrelated to changes in peripheral plasma SLI, GLI, or IRI induced by TRH infusion.
mesh_terms: D000375:Aging; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004372:Ducks / Q000378:metabolism*; D005934:Glucagon / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D007328:Insulin / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D013004:Somatostatin / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone; D013006:Growth Hormone; D005934:Glucagon