title: Effects of vitamin C deficiency on physiology of male reproductive organs of guinea pigs.
abstract: Vitamin C dietary deficiency in guinea pigs markedly affected the androgen-sensitive parameters of the reproductive tissues--testis, epididymis, vas deferens, and accessory sex glands--and caused an "androgen-deprived effect" in these target organs. This in turn altered their internal milieu and caused changes in their metal ion profile and the morphology, motility, and density of spermatozoa in the cauda epididymis and vas deferens. The sensitivity of the vas deferens to adrenaline was also reduced in scorbutic guinea pigs, thus decreasing their fertility rate. The primary action seems to be at the level of the testis, and androgen deprivation and partial antifertility effects are probably secondary manifestations consequent to the primary effect. The present study demonstrated that ascorbic acid is essential for maintaining the physiological integrity of the androgen target reproductive organs in guinea pigs.
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis; D001206:Ascorbic Acid Deficiency / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002784:Cholesterol / Q000032:analysis; D002802:Cholinesterases / Q000032:analysis; D002951:Citrates / Q000032:analysis; D019343:Citric Acid; D005632:Fructose / Q000032:analysis; D005837:Genitalia, Male / Q000378:metabolism* / Q000473:pathology; D005978:Glutathione / Q000032:analysis; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008670:Metals / Q000032:analysis; D009119:Muscle Contraction; D009929:Organ Size; D011506:Proteins / Q000032:analysis; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000201:enzymology; D013385:Succinate Dehydrogenase / Q000032:analysis; D014649:Vas Deferens / Q000503:physiopathology
chemical_list: D002951:Citrates; D008670:Metals; D011506:Proteins; D019343:Citric Acid; D005632:Fructose; D002784:Cholesterol; D013385:Succinate Dehydrogenase; D002802:Cholinesterases; D005978:Glutathione; D001205:Ascorbic Acid