title: The same MHC recombinational hot spots are active in crossing-over between wild/wild and wild/inbred mouse chromosomes.
abstract: Four recombinational breakpoints were mapped in the K-A interval of the mouse major histocompatibility complex (MHC) by Southern blot analysis. The breakpoint in B10.SBR, containing a b/s recombinant MHC haplotype, is located about 45 kb upstream of the A beta 2 gene close to the breakpoint in B10.AQR. Crossover in two cas3/cas4 and one cas4/cas3 recombinant haplotypes has taken place in the previously identified K/A beta 3 and A beta 3/A beta 2 recombinational hot spots. The same hot spots are thus active in crossover between two Mus musculus castaneus MHC haplotypes and in crossover between a laboratory and a M. m. castaneus MHC haplotype.
mesh_terms: D000818:Animals; D000835:Animals, Wild / Q000235:genetics*; D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes; D005805:Genes, MHC Class I; D006239:Haplotypes; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic
chemical_list: D004262:DNA Restriction Enzymes