Anomeric specificity of glucose-induced somatostatin secretion.
In isolated perfused rat pancreases, the alpha-anomer of D-glucose is more potent than beta-D-glucose not solely in stimulating insulin release and suppressing glucagon output, but also in causing somatostatin secretion.
D000818:Animals; D005260:Female; D005934:Glucagon / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007700:Kinetics; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011924:Rats, Zucker; D013004:Somatostatin / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D007328:Insulin; D013004:Somatostatin; D005934:Glucagon; D005947:Glucose