Clonidine reduces plasma melatonin levels.
Clonidine, an alpha-adrenoceptor agonist, reduces human plasma melatonin levels when administered intravenously at 2-3 micrograms kg-1 to sleeping volunteers. Measurement of plasma melatonin levels after administration of clonidine could be the basis for a clinical in-vivo test of alpha-adrenoceptors.
D000328:Adult; D003000:Clonidine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000097:blood*; D008875:Middle Aged
D008550:Melatonin; D003000:Clonidine