title: Arginine vasopressin as a thyrotropin-releasing hormone.
abstract: Although hypothyroidism (with concomitant increased levels of thyroid-stimulating hormone) has been associated with elevated plasma vasopressin, the role that vasopressin plays in controlling thyroid-stimulating hormone secretion from the adenohypophysis is not understood. In two in vitro pituitary cell systems, vasopressin caused a specific and dose-related release of thyroid-stimulating hormone from cells that was equal in potency to that elicited by thyrotropin-releasing hormone, the primary acknowledged regulator of thyroid-stimulating hormone release. When injected into the hypothalamus, however, vasopressin specifically inhibited the release of thyroid-stimulating hormone. Thus, vasopressin may exert differential regulatory effects on thyroid-stimulating hormone secretion in the hypothalamus and pituitary gland.
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology* / Q000502:physiology; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010121:Oxytocin / Q000494:pharmacology; D010477:Perfusion; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000494:pharmacology; D013972:Thyrotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
chemical_list: D001127:Arginine Vasopressin; D010121:Oxytocin; D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin