Potentiation of contractile response and increase in tissue sodium content induced by aconitine in the guinea-pig vas deferens.
Aconitine potentiated the contractile response of the guinea-pig vas deferens and increased the tissue Na and Ca content. These effects were abolished in the presence of tetrodotoxin. These results suggest that aconitine causes an increasing Na+ permeability of the smooth muscle membrane to increase Ca2+ availability and thus induces potentiation.
D000157:Aconitine / Q000494:pharmacology*; D031841:Aconitum / Q000031:analogs & derivatives*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D006224:Cricetinae; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D012964:Sodium / Q000032:analysis*; D013779:Tetrodotoxin / Q000494:pharmacology; D014649:Vas Deferens / Q000032:analysis / Q000187:drug effects
D013779:Tetrodotoxin; D012964:Sodium; D002118:Calcium; D009638:Norepinephrine; D000157:Aconitine