Localization of plutonium retention in the small intestine of the neonatal rat, guinea pig, baboon and macaca after Pu-citrate ingestion.
The retention of Pu-citrate in the gastrointestinal wall was compared at similar post ingestion times after ingestion at 2 days of age by rats and guinea pigs and at 1 to 34 days by neonatal primates. The small intestine was the main site of the Pu retention in all species. In rats and primates, most of the Pu was retained in the distal ileum, whereas in guinea pigs it was more homogeneously distributed. In the rats, Pu was retained in the epithelial cells on villi, but in the guinea pigs and primates it was confined to the macrophages under the epithelial cells in the lacteal region.
D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D002520:Cercopithecidae / Q000378:metabolism*; D004064:Digestive System / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006168:Guinea Pigs / Q000378:metabolism*; D007082:Ileum / Q000378:metabolism / Q000648:ultrastructure; D007420:Intestine, Large / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism* / Q000648:ultrastructure; D008253:Macaca mulatta / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D008854:Microscopy, Electron; D008871:Microvilli / Q000378:metabolism; D010215:Papio / Q000378:metabolism; D011005:Plutonium / Q000493:pharmacokinetics*; D051381:Rats / Q000378:metabolism*; D014018:Tissue Distribution
D011005:Plutonium