Induction of ornithine decarboxylase activity in rat lung by neurotransmitters and peptide hormones.
Ornithine decarboxylase activity of rat lung was induced by s.c. injection of acetylcholine, norepinephrine, epinephrine, dopamine, serotonin, vasopressin, angiotensin II, and adrenocorticotropic hormone, but not by gonadotropin, aldosterone, corticosterone or hydrocortisone. The possible significance of hormonal factors in lung carcinogenesis is discussed, based on the reported promoting activity of vasopressin in cultured cells.
D000109:Acetylcholine / Q000494:pharmacology; D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D006062:Gonadotropins / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000201:enzymology*; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology; D014667:Vasopressins / Q000494:pharmacology
D006062:Gonadotropins; D006728:Hormones; D018377:Neurotransmitter Agents; D014667:Vasopressins; D012701:Serotonin; D000450:Aldosterone; D009955:Ornithine Decarboxylase; D000109:Acetylcholine; D004298:Dopamine; D003345:Corticosterone; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine