Detection of SSEA-1 on human renal tumors.
Stage-specific embryonic antigen-1 (SSEA-1) was localized on paraffin embedded, formalin fixed specimens of human renal tumors by immunoperoxidase staining using a monoclonal antibody. Of 19 renal cell carcinoma (RCC) samples tested, 12 were positive for SSEA-1; SSEA-1 was also found on distinct elements in two samples of Wilms' tumor. No correlation was found between expression of SSEA-1, and RCC morphology or pattern of growth. Because SSEA-1 is found on proximal tubules in the normal kidney, these results support the hypothesis that RCC arises from the cells of the proximal tubule. Furthermore, since greater than 60% of the RCCs examined expressed SSEA-1, this antigen may prove to be a useful target for immunolocation or therapy of metastatic RCC.
D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D002292:Carcinoma, Renal Cell / Q000276:immunology*; D005629:Frozen Sections; D006017:Glycolipids / Q000032:analysis*; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007680:Kidney Neoplasms / Q000276:immunology*; D016256:Lewis X Antigen; D010232:Paraffin; D009396:Wilms Tumor / Q000276:immunology*
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D006017:Glycolipids; D016256:Lewis X Antigen; D010232:Paraffin