Effect of vanadate on cooling-induced tension changes in K-depolarized smooth muscles from guinea-pigs.
Sodium vanadate reversed cooling-induced relaxation of K-depolarized taenia coli of guinea-pigs but failed to reverse it in the portal vein and uterus. It potentiated cooling-induced contraction of K-depolarized vas deferens and ureter. These effects were not mediated by the inhibition of Na,K-ATPase, but by the inhibition of the Ca-pump.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D003080:Cold Temperature; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011188:Potassium / Q000494:pharmacology*; D014638:Vanadates / Q000494:pharmacology*; D014649:Vas Deferens / Q000187:drug effects
D014638:Vanadates; D011188:Potassium; D002118:Calcium