Oral administration of diltiazem decreases ventilation and metabolism of Syrian hamsters.
1. Diltiazem at doses of 2.5, 25, and 50 mg/kg caused a reduction of minute ventilation of hamsters over a 60 min period compared to saline administration. 2. The decrease of ventilation was due to a fall in frequency of breathing, but predominantly due to a decrease of tidal volume. 3. The pattern of metabolic response of hamsters to diltiazem was different to the ventilatory response--but metabolic rate was decreased in all animals receiving diltiazem by 60 min compared to pregavage values.
D000818:Animals; D006224:Cricetinae / Q000502:physiology*; D004110:Diltiazem / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008647:Mesocricetus / Q000378:metabolism / Q000502:physiology*; D010101:Oxygen Consumption / Q000187:drug effects; D012119:Respiration / Q000187:drug effects*
D004110:Diltiazem