Somatostatin immunoneutralization overcomes the inhibitory effects of quipazine and pargyline on growth hormone secretion in domestic fowl.
The inhibitory effects of pargyline and quipazine on chicken growth hormone secretion were overcome by passive immunoneutralization of endogenous somatostatin (SRIF)-14 or SRIF-28(1-14)-like immunoreactivity. Administration of the specific antisera to control birds pretreated with 0.9% NaCl elevated the basal plasma GH concentrations. These results suggest that peptides with SRIF-14 or SRIF-28(1-14)-like immunoreactivity tonically inhibit GH secretion and are at least partially responsible for the inhibitory effects of pargyline and quipazine on GH release in immature domestic fowl.
D000818:Animals; D002645:Chickens; D013006:Growth Hormone / Q000378:metabolism*; D007116:Immunization, Passive; D008297:Male; D010293:Pargyline / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000494:pharmacology*; D013004:Somatostatin / Q000276:immunology / Q000502:physiology*; D053561:Somatostatin-28
D011804:Quinolines; D011814:Quipazine; D013004:Somatostatin; D053561:Somatostatin-28; D013006:Growth Hormone; D010293:Pargyline