title: Lymphocyte gamma-glutamyltranspeptidase activity in ataxia-telangiectasia.
abstract: gamma-Glutamyltranspeptidase (GGTP) is a membrane-bound enzyme, that catalyzes gamma-glutamyl transfer from gamma-glutamyl compounds to amino acid and peptide acceptors. One of the most important clinical findings about ataxia-telangiectasia (A-T), a multisystemic and autosomal-recessive disease, is dysfunction of the immune system. In this study, the activity of GGTP was determined in the lymphocytes from patients with A-T. Lymphocyte GGTP activity in A-T patients was found to be significantly lower than that of control lymphocytes (P less than 0.001). This change may be due to the abnormality in the membrane of lymphocytes of A-T patients.
mesh_terms: D000293:Adolescent; D001260:Ataxia Telangiectasia / Q000201:enzymology*; D002462:Cell Membrane / Q000201:enzymology; D002648:Child; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology*; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D005723:gamma-Glutamyltransferase