Possible role of excitatory amino acids in the convulsant action of catechol.
The effects of several excitatory amino acid receptor antagonists on sensory-evoked electromyographic activity induced by catechol have been studied in urethane-anaesthetised rats. 2-Amino-5-phosphono-valearic acid (1.2 mumol/kg i.c.), cis-2,3-piperidine dicarboxylic acid (1.4 mumol/kg i.c.), gamma-D-glutamyl-glycine (2.0 mumol/kg i.c.), 2-amino-7-phosphono-heptanoic acid (230 mumol/kg i.v.) and MK-801 (5 mg/kg i.p.) all significantly decreased the frequency of occurrence of those components of the sensory evoked EMG dependent on supraspinal structures, but were without effect on the spinal component.
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives; D000596:Amino Acids / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D002396:Catechols / Q000494:pharmacology*; D003986:Dibenzocycloheptenes / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology; D016291:Dizocilpine Maleate; D004576:Electromyography; D005260:Female; D010875:Pipecolic Acids / Q000494:pharmacology; D051381:Rats; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced*; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
D000596:Amino Acids; D002396:Catechols; D003986:Dibenzocycloheptenes; D004151:Dipeptides; D010875:Pipecolic Acids; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface; C028929:gamma-glutamylglycine; C029262:2,3-piperidinedicarboxylic acid; D016291:Dizocilpine Maleate; D015763:2-Amino-5-phosphonovalerate; D014633:Valine; C031231:2-amino-7-phosphonoheptanoic acid