The action of dopamine upon glycerol and fatty acid release by rat brown adipose tissue.
Dopamine was shown to be effective in releasing glycerol and nonesterified fatty acid from brown fat adipocytes. The response was inhibited by dopamine-antagonists, and by a beta-blocker. This is further evidence that dopamine may be important in the release of energy from brown fat in newborn and cold-adapted animals.
D000222:Adaptation, Physiological; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D003080:Cold Temperature; D004298:Dopamine / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005260:Female; D005990:Glycerol / Q000378:metabolism*; D066298:In Vitro Techniques; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D005230:Fatty Acids, Nonesterified; D011954:Receptors, Dopamine; D005990:Glycerol; D004298:Dopamine