title: Pre-treatment with somatostatin in the anaesthetic management of a patient with carcinoid syndrome.
abstract: Carcinoid syndrome produces flushing, bronchoconstriction and gastrointestinal hypermotility secondary to serotonin, histamine, bradykinin and prostaglandin release. A variety of drugs, foods and anaesthetic agents may provoke this syndrome. Under anaesthesia, the flushing produced may be associated with acute hypotension and cardiovascular collapse; this phenomenon is called a carcinoid crisis. Recently, somatostatin analogue has been used successfully to treat intraoperative carcinoid crisis. In this report, we present a 66-year-old lady with carcinoid syndrome who was pre-treated with 50 micrograms somatostatin analogue IV and IM prior to surgical manipulation. The anaesthetic course was relatively uneventful and the patient did well postoperatively.
mesh_terms: D000368:Aged; D000768:Anesthesia, General; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000601:surgery; D008303:Malignant Carcinoid Syndrome / Q000503:physiopathology / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000601:surgery; D011292:Premedication; D013004:Somatostatin / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D013004:Somatostatin