title: The presence of intersexuality in patients with advanced hypospadias and undescended gonads.
abstract: We studied 20 patients with advanced degrees of hypospadias and undescended testes for the presence of an intersex disorder. A comprehensive clinical, cytogenetic, endocrinological and surgical evaluation was performed. All patients were found to have an intersex disorder, including 10 with male pseudohermaphroditism and 10 with a gonadal/genetic intersex disorder. In the latter group 4 patients had mixed gonadal dysgenesis, 3 had dysgenetic male pseudohermaphroditism, 1 had the 46XX male syndrome, 1 had true hermaphroditism and 1 had Klinefelter's syndrome. Genetic and gonadal intersex disorders were more frequent in patients with a unilateral undescended testis and perineal hypospadias.
mesh_terms: D002648:Child; D002675:Child, Preschool; D003456:Cryptorchidism / Q000235:genetics*; D012734:Disorders of Sex Development / Q000235:genetics*; D006060:Gonadal Dysgenesis, Mixed / Q000235:genetics; D006801:Humans; D007021:Hypospadias / Q000235:genetics*; D007223:Infant; D007621:Karyotyping; D008297:Male