The UGI series in renal transplant candidates.
We reviewed the charts of 115 renal transplant recipients who had pre-transplant upper gastrointestinal (UGI) barium examinations to assess this examination as a predictor of post-transplant ulceration and hemorrhage. In the past surgical therapy for peptic ulcers was recommended before transplantation because of the risk of life-threatening hemorrhage after transplantation. Peptic ulcer disease was found in 22 patients. Fifteen of these were treated with histamine H2-receptor antagonists and none had ulceration post-transplantation. Three of the seven not so treated had recurrent peptic ulceration. The other 93 examinations were normal. Twelve of the patients with normal examinations developed post-transplant peptic ulceration. We conclude that: (a) the pre-transplant UGI series may not distinguish those patients at risk of UGI ulceration post-transplantation and (b) treatment with H2-receptor antagonists obviates the need for surgical therapy of peptic ulcer disease in these patients before transplantation.
D001466:Barium Sulfate; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D016030:Kidney Transplantation; D010437:Peptic Ulcer / Q000000981:diagnostic imaging* / Q000517:prevention & control; D010438:Peptic Ulcer Hemorrhage / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D011300:Preoperative Care; D011859:Radiography; D012307:Risk Factors
D006635:Histamine H2 Antagonists; D001466:Barium Sulfate