The dissolution rate and bioavailability of hydrochlorothiazide in pellet formulations.
The influence of non-active ingredients in the manufacture of pellets on in-vitro dissolution rate and on bioavailability of hydrochlorothiazide has been studied. Pellets were formulated using either microcrystalline cellulose or microcrystalline cellulose-carboxymethylcellulose sodium blends as matrix, and hydrochlorothiazide as the active ingredient. In-vitro drug release from the different pellet formulations was retarded in comparison to a conventional tablet formulation and was dependent on the nature of the non-active ingredient and, for the microcrystalline cellulose-carboxymethylcellulose sodium blend, of the dissolution medium. In-vivo bioavailability of both pellet formulations was low compared with that of the conventional tablet and the plasma concentration-time profiles did not suggest slow release.
D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000032:analysis* / Q000493:pharmacokinetics; D008297:Male; D012995:Solubility; D013607:Tablets
D013607:Tablets; D006852:Hydrochlorothiazide