title: Somatostatin immunoneutralization overcomes the inhibitory effects of quipazine and pargyline on growth hormone secretion in domestic fowl.
abstract: The inhibitory effects of pargyline and quipazine on chicken growth hormone secretion were overcome by passive immunoneutralization of endogenous somatostatin (SRIF)-14 or SRIF-28(1-14)-like immunoreactivity. Administration of the specific antisera to control birds pretreated with 0.9% NaCl elevated the basal plasma GH concentrations. These results suggest that peptides with SRIF-14 or SRIF-28(1-14)-like immunoreactivity tonically inhibit GH secretion and are at least partially responsible for the inhibitory effects of pargyline and quipazine on GH release in immature domestic fowl.
mesh_terms: D000818:Animals; D002645:Chickens; D013006:Growth Hormone / Q000378:metabolism*; D007116:Immunization, Passive; D008297:Male; D010293:Pargyline / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000494:pharmacology*; D013004:Somatostatin / Q000276:immunology / Q000502:physiology*; D053561:Somatostatin-28
chemical_list: D011804:Quinolines; D011814:Quipazine; D013004:Somatostatin; D053561:Somatostatin-28; D013006:Growth Hormone; D010293:Pargyline