Anticataleptic effect of taurine: interaction with antiparkinsonian agents.
The influence of taurine on cataleptogenic effect of neuroleptics was investigated in male Wistar rats. It was found that taurine 900 micrograms/rat icv reduced significantly haloperidol or fluphenazine-induced catalepsy. In rats receiving taurine in a dose of 450 micrograms, not influencing catalepsy, with low doses of anticholinergic antiparkinsonian agents (trihexyphenidyl and pridinol) strong anticataleptic effect was observed. The results suggest that taurine facilitates neurotransmission in nigrostriatal dopaminergic neurons.
D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy*; D004347:Drug Interactions; D008297:Male; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000494:pharmacology*; D014282:Trihexyphenidyl / Q000494:pharmacology
D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D010880:Piperidines; D013654:Taurine; D014282:Trihexyphenidyl; C009185:pridinol