Teratology studies of compound LY171883 administered orally to rats and rabbits.
The teratogenic potential of the leukotriene antagonist LY171883, a novel antiasthma agent, was investigated in CD rats and Dutch Belted rabbits. Mated female rats were dosed with 0, 10, 65, or 425 mg/kg/day on gestation days 6 through 15 and killed on gestation day 20. Mated female rabbits were dosed with 0, 20, 65, or 200 mg/kg/day on gestation days 6 through 18 and killed on gestation day 28. Maternal toxicity was indicated at 425 mg/kg in rats and 200 mg/kg in rabbits by depressed body weight gain and food consumption. In the rabbit study four abortions occurred at 200 mg/kg, most likely secondarily to maternal toxicity. LY171883 did not cause embryo/fetal toxicity or teratogenicity in rats or rabbits at doses up to and including those that were maternally toxic.
D000098:Acetophenones / Q000633:toxicity*; D000284:Administration, Oral; D000818:Animals; D012898:Autacoids / Q000037:antagonists & inhibitors*; D001393:Azoles / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013723:Teratogens; D013777:Tetrazoles / Q000633:toxicity*
D000098:Acetophenones; D012898:Autacoids; D001393:Azoles; D013723:Teratogens; D013777:Tetrazoles; C044660:LY 171883