Decreased somatostatin immunoreactivity but not neuropeptide Y immunoreactivity in cerebral cortex in senile dementia of Alzheimer type.
The content of two neuropeptides, somatostatin (SRIF) and neuropeptide Y (NPY) has been determined in two cerebral cortical areas of Alzheimer's disease brain and in age-matched control brains. The content of SRIF-like immunoreactivity (SRIF-LI) was found to be decreased in Alzheimer temporal cortex (Brodmann area 21) compared to control temporal cortex. The decreased content of SRIF was significantly correlated with the observed number of neuritic plaques and neurofibrillary tangles. No difference was observed in NPY-LI between Alzheimer cerebral cortex and control cortex. Furthermore, no correlations were observed between NPY content and plaque count, neurofibrillary tangle estimate or SRIF content despite widespread reports of NPY/SRIF coexistence.
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D002540:Cerebral Cortex / Q000032:analysis* / Q000473:pathology; D005625:Frontal Lobe / Q000032:analysis; D006801:Humans; D009454:Neurofibrils / Q000473:pathology; D009478:Neuropeptide Y / Q000032:analysis*; D010296:Parietal Lobe / Q000032:analysis; D013004:Somatostatin / Q000032:analysis*
D009478:Neuropeptide Y; D013004:Somatostatin