Treatment of anismus in intractable constipation with botulinum A toxin.
In seven patients with anismus the striated sphincter muscle complex was selectively weakened by local injection of Clostridium botulinum type A toxin. Symptom scores improved significantly and correlated with a significant reduction in the maximum voluntary and canal squeeze pressure and a significant increase in the anorectal angle on straining. Botulinum A toxin seems to be promising treatment for some patients with anismus.
D000328:Adult; D000368:Aged; D001004:Anus Diseases / Q000188:drug therapy*; D001905:Botulinum Toxins / Q000008:administration & dosage / Q000627:therapeutic use*; D003248:Constipation / Q000188:drug therapy* / Q000503:physiopathology; D004576:Electromyography; D005069:Evaluation Studies as Topic; D006801:Humans; D007273:Injections, Intramuscular; D008875:Middle Aged; D009122:Muscle Hypertonia / Q000188:drug therapy*; D012720:Severity of Illness Index; D013997:Time Factors
D001905:Botulinum Toxins