Possible interaction of the adrenal-gonadal systems on brain catecholamines of adult male rats.
Studies from this laboratory showed that gonadectomy (GDX) alters biogenic amines concentrations in diencephalon during the first 40 days. While the GDX females maintain the differences at day 60, the differences are eliminated in males at that time. In the present work, we have studied in three cerebral regions the adrenal involvement in the mechanism responsible for this normalization of catecholamine concentration in long-term castrated adult male rats. A hypersecretion of adrenal steroids seems to compensate for the lack of gonadal effect when the orchidectomized rats reach adulthood only for diencephalic dopamine.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D001921:Brain / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D004027:Diencephalon / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D008032:Limbic System / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D009919:Orchiectomy; D051381:Rats; D013737:Testis / Q000502:physiology*
D004298:Dopamine; D009638:Norepinephrine