Effect of serotonin on bethanechol-stimulated gastric pepsin secretion in dogs.
The effect of serotonin on bethanechol-stimulated gastric pepsin secretion was evaluated with regard to dose-response kinetics and receptor mediation. A low dose of exogenous serotonin produced a stimulation (0.5 microgram/kg/min), whereas inhibition was found for higher doses (5-10 micrograms/kg/min). The inhibition was non-competitive and could be significantly counteracted by beta-adrenergic blocking drugs. This study confirms results obtained during pentagastrin stimulation and supports the concept that serotonin acts via sympathetic nerves to release noradrenaline.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D007700:Kinetics; D008297:Male; D010434:Pepsin A / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D001626:Bethanechol Compounds; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D018723:Bethanechol; D012701:Serotonin; D010434:Pepsin A