Importance of endogenous substrates in synaptosomal functions.
Synaptosomes were found to contain endogenous substrates in sufficient amount to support physiological ion equilibrium and to maintain the resting oxygen consumption rate. Exogenous substrates were required only in functional states which brought about an increase of oxygen consumption only in the presence of a stimulating agent. Succinate increased oxygen consumption even in the resting phase but proved to be incapable of supplying energy for synaptosomal ion transport processes.
D019297:2,4-Dinitrophenol; D000625:Aminooxyacetic Acid / Q000378:metabolism; D004140:Dinitrophenols / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D010101:Oxygen Consumption; D011188:Potassium / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D012402:Rotenone / Q000494:pharmacology; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid; D013574:Synaptosomes / Q000378:metabolism*
D004140:Dinitrophenols; D005971:Glutamates; D011773:Pyruvates; D013386:Succinates; D012402:Rotenone; D000625:Aminooxyacetic Acid; D018698:Glutamic Acid; D019289:Pyruvic Acid; D019802:Succinic Acid; D005947:Glucose; D019297:2,4-Dinitrophenol; D011188:Potassium