Thyroxine-induced changes in rat liver mitochondrial ubiquinone.
Ubiquinone was extracted from liver mitochondria isolated from euthyroid and hyperthyroid rats. The redox state of ubiquinone was determined during States III and IV respiration with succinate or glutamate-malate substrates. Ubiquinone was more reduced during State III or IV in the hyperthyroid mitochondria with either substrate. Furthermore, the concentration of ubiquinone increased in the hyperthyroid rats.
D000818:Animals; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D006980:Hyperthyroidism / Q000378:metabolism; D008293:Malates / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid; D013974:Thyroxine / Q000494:pharmacology*; D014451:Ubiquinone / Q000378:metabolism*
D005971:Glutamates; D008293:Malates; D013386:Succinates; D014451:Ubiquinone; D018698:Glutamic Acid; C030298:malic acid; D019802:Succinic Acid; D013974:Thyroxine