title: High-dose versus low-dose intravenous immunoglobulin in hypogammaglobulinaemia and chronic lung disease.
abstract: In a randomised cross-over study 12 patients with antibody deficiency and chronic lung disease received monthly infusions of either 0.6 g/kg or 0.2 g/kg intravenous immunoglobulin for six months, and were then switched to the alternative dose for a further six months. Although the incidence of infections did not differ greatly in the high-dose and low-dose phases, the frequency of acute infection was substantially reduced in those periods when serum IgG was 500 mg/dl or more. Pulmonary function worsened on the low-dose regimen and improved on the high-dose regimen.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000628:therapy*; D002648:Child; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008171:Lung Diseases / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests
chemical_list: D007074:Immunoglobulin G