Oral absorption of metronidazole in rabbits irradiated with cobalt-60 gamma radiation.
The absorption of oral metronidazole in control rabbits and in rabbits irradiated with cobalt-60 gamma radiation was studied. It was observed that the bioavailability of metronidazole was significantly reduced in irradiated animals the reduction being dependent on the dose of radiation. The maximum decrease in absorption was seen 48 h post-irradiation.
D000818:Animals; D001682:Biological Availability; D003124:Colorimetry; D005260:Female; D005720:Gamma Rays; D008297:Male; D008795:Metronidazole / Q000493:pharmacokinetics*; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000378:metabolism*
D008795:Metronidazole