Effects of varying inducer type and dose on hepatic monooxygenase activities in the mountain vole Microtus montanus.
Hepatic monooxygenase activities of the mountain vole, Microtus montanus, were measured after i.p. injections of phenobarbital, B-naphthoflavone and Aroclor 1254 at doses ranging from 5 to 80 mg/kg. The results showed that mountain voles differed in their induction of hepatic monooxygenase activity relative to other rodents. The results also suggest substrate specificity in the detection of enzymatic induction and the importance of considering effects of varying inducer doses on hepatic monooxygenases.
D000815:Aniline Hydroxylase / Q000378:metabolism*; D000818:Animals; D001140:Aroclors / Q000494:pharmacology*; D003411:Arvicolinae / Q000378:metabolism*; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D001571:Benzoflavones / Q000494:pharmacology*; D020111:Chlorodiphenyl (54% Chlorine); D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D007700:Kinetics; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009575:Nitroanisole O-Demethylase / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology*; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D019324:beta-Naphthoflavone
D001140:Aroclors; D001571:Benzoflavones; D005419:Flavonoids; D020111:Chlorodiphenyl (54% Chlorine); D019324:beta-Naphthoflavone; D011078:Polychlorinated Biphenyls; D009575:Nitroanisole O-Demethylase; D010088:Oxidoreductases; D000815:Aniline Hydroxylase; D001189:Aryl Hydrocarbon Hydroxylases; D010634:Phenobarbital