Non-Hodgkin's lymphoma containing both B and T cell clones.
We describe a patient in whom two lymph node biopsies removed 18 months apart disclosed histologic and immunophenotypic evidence of a non-Hodgkin's lymphoma containing neoplastic lymphocytes of both B and T type. Analyses of immunoglobulin and T cell receptor genes confirmed the presence of separate B and T cell clones. In addition, immunogenotyping revealed the possibility of a second B cell clone within the patient's tumor. Development of a multiclonal lymphoma in this patient may relate to the carcinogenic effects of chemotherapy or to a predisposition for neoplastic transformation of lymphocytes due to a previously diagnosed autoimmune condition. Another possible explanation is that the lymphoma implies the existence in this patient of a transformed lymphocyte-committed stem cell that is capable of generating both B and T lineage clones.
D001402:B-Lymphocytes / Q000166:cytology*; D001706:Biopsy; D002999:Clone Cells; D005260:Female; D005838:Genotype; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000235:genetics; D008198:Lymph Nodes / Q000166:cytology; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008875:Middle Aged; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes / Q000166:cytology*
D007136:Immunoglobulins; D011948:Receptors, Antigen, T-Cell