The antinociceptive effects of prostaglandin antagonists in the rat.
This study examined the antinociceptive effects of two prostaglandin antagonists, SC-25469 and SC-19220 in the rat. SC-25469 and SC-19220 inhibited acetic acid-induced writhing with ED50 s of 6.9 and 6.8 mg/kg p.o., respectively. When compared to other analgesics, the rank order of potency in the writhing test was morphine greater than pentazocine = U-50,488 greater than SC-25469 = SC-19220 greater than ibuprofen greater than aspirin greater than acetaminophen. SC-25469 (150 and 300 mg/kg p.o.) and SC-19220 (50-300 mg/kg p.o.) also suppressed the behavioral response to s.c. injection of formalin, as did aspirin (50-150 mg/kg p.o.), ibuprofen (25-100 mg/kg p.o.) and acetaminophen (300 mg/kg p.o.). However, the suppression was not of the magnitude observed after administration of morphine (ED50: 0.9 mg/kg s.c.), pentazocine (ED50: 2.4 mg/kg s.c.) or U-50,488 (ED50: 0.8 mg/kg s.c.). This study demonstrates the antinociceptive properties of prostaglandin antagonists in two distinct tests of nociception.
D000082:Acetaminophen / Q000627:therapeutic use; D000700:Analgesics; D000818:Animals; D001241:Aspirin / Q000627:therapeutic use; D012531:Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide / Q000031:analogs & derivatives / Q000494:pharmacology*; D003989:Dibenzoxazepines / Q000494:pharmacology*; D007052:Ibuprofen / Q000627:therapeutic use; D008297:Male; D010147:Pain Measurement / Q000379:methods; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D003989:Dibenzoxazepines; D011448:Prostaglandin Antagonists; D012531:Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; D000082:Acetaminophen; C051983:pinadoline; D001241:Aspirin; D007052:Ibuprofen