Role of quisqualic acid receptors in the hypermotility response produced by the injection of AMPA into the nucleus accumbens.
alpha-Amino-3-hydroxy-5- methylisoxazole-4-propionate (AMPA) is an excitatory amino acid which on the basis of electrophysiological and binding studies appears to act as a quisqualic acid receptor agonist. AMPA and other excitatory amino acids, such as quisqualic acid, kainic acid, and N-methyl-D-aspartic acid, as well as picrotoxin, an inhibitor of endogenous GABA, produce a marked stimulation of locomotor activity after bilateral injection into the nucleus accumbens. The intraacumbens injection of gamma-D-glutamylaminomethylsulphonate (GAMS) was found to inhibit the hypermotility responses produced by AMPA and quisqualic acid at doses that were unable to inhibit the hypermotility responses produced by kainic acid, N-methyl-D-aspartic acid, and picrotoxin. These results suggest that GAMS is able to selectively inhibit quisqualic acid receptors in the nucleus accumbens. The intraacumbens injection of D-alpha-aminoadipic acid at a dose that significantly inhibited N-methyl-D-aspartic acid-stimulated locomotor activity did not produce a significant inhibition of AMPA-stimulated locomotor activity, suggesting that AMPA is not acting at N-methyl-D-aspartic acid receptors. Thus, these results suggest that the activation of quisqualic acid receptors in the nucleus accumbens produces a hypermotility response.
D015074:2-Aminoadipic Acid / Q000494:pharmacology; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology; D005973:Glutamine / Q000031:analogs & derivatives*; D007051:Ibotenic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007267:Injections; D007608:Kainic Acid / Q000494:pharmacology; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D016202:N-Methylaspartate; D009714:Nucleus Accumbens; D010069:Oxadiazoles / Q000494:pharmacology; D010080:Oxazoles / Q000494:pharmacology*; D016318:Quisqualic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D018091:Receptors, AMPA; D011955:Receptors, Drug / Q000502:physiology*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
D005971:Glutamates; D010069:Oxadiazoles; D010080:Oxazoles; D018091:Receptors, AMPA; D011955:Receptors, Drug; D005973:Glutamine; D015074:2-Aminoadipic Acid; D007051:Ibotenic Acid; D001224:Aspartic Acid; D016202:N-Methylaspartate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D016318:Quisqualic Acid; C042626:gamma-glutamylaminomethylsulfonic acid; D007608:Kainic Acid