[Assessment of the action of taktivin on different stages of T-lymphocyte maturation].
Tactivin, the thymic hormone preparation, evokes some phenotype alterations in T-cell precursors (elimination of SC-1 antigen and expression of Thy-1-antigen) and cortical thymocytes (a decrease in the number of thymocytes carrying PNA-receptor) similar to those arising in T-cell differentiation. Tactivin induces PNA+ -thymocyte response to PHA action and increases PHA response to PNA- -thymocytes. It is weakly mitogenic for T-cell precursors and PNA- -thymocytes. The data suggest that Tactivin may be used for the treatment of immune deficiencies with T-cell differentiation and function defects.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000941:Antigens / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D002453:Cell Cycle / Q000187:drug effects; D002478:Cells, Cultured; D051379:Mice; D008808:Mice, Inbred CBA; D010455:Peptides / Q000494:pharmacology*; D010641:Phenotype; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D018800:Thy-1 Antigens; D013949:Thymus Extracts / Q000494:pharmacology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
D000276:Adjuvants, Immunologic; D000941:Antigens; D000954:Antigens, Surface; D010455:Peptides; D018800:Thy-1 Antigens; D013949:Thymus Extracts; C036191:T-activin
Otsenka deĭstviia taktivina na razlichnye stadii sozrevaniia T-limfotsitov.