title: Separation and determination of isopropamide iodide in pharmaceutical formulations by reversed-phase ion-pair high-performance liquid chromatography.
abstract: A stability-indicating determination for isopropamide iodide, an anticholinergic quaternary ammonium drug, in several pharmaceutical dosage forms by reversed-phase ion-pair liquid chromatography is reported. The use of eluents containing both an amine as well as an alkylsulphonate proved to be very efficient for separating and determining quaternary ammonium drugs and related other basic drugs: adequate selectivity, excellent peak shape and good reproducibility (coefficient of variation, 1-2%) were obtained in a short analysis time.
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D011786:Quality Control; D000644:Quaternary Ammonium Compounds / Q000302:isolation & purification*; D012996:Solutions; D012997:Solvents; D013607:Tablets
chemical_list: D000644:Quaternary Ammonium Compounds; D012996:Solutions; D012997:Solvents; D013607:Tablets