A mouse homeo box gene, Hox-1.5, and the morphological locus, Hd, map to within 1 cM on chromosome 6.
Mo-10, a homeo box-containing sequence in the Hox-1 complex of genes referred to as Hox-1.5, was found to be polymorphic in inbred and wild mice, and a strain distribution of three allelic forms of Hox-1.5 are reported. The position of Hox-1.5 was mapped in backcross experiments to within 1 cM of the hypodactyly locus on chromosome 6. This identifies the Hd mutation as a useful model for the examination of homeo box expression during mammalian development.
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004247:DNA / Q000302:isolation & purification; D005260:Female; D005801:Genes, Homeobox; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D011995:Recombination, Genetic
D004247:DNA