The effect of anti-inflammatory and rheumatoid disease modifying drugs on prolonged immune and non-immune inflammation in the six-day air pouch of rats.
The six-day air pouch model of synovitis in rats was used to study the effects of non-steroidal and anti-rheumatic drugs on cell accumulation and exudate formation. Inflammation was induced in the six-day air pouch either with the non-immune irritant carrageenan or the immune irritant Bordetella pertussis. Indomethacin reduced cell accumulation and exudate formation in both models. In contrast levamisole and D-penicillamine were unable to reduce either parameter, D-penicillamine actually producing at certain times a pro-inflammatory effect. The steroid dexamethasone caused the total inhibition of inflammatory exudate formation and cell accumulation. The six-day air pouch of rats may therefore be useful for the detection of agents which inhibit chronic inflammation.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001886:Bordetella pertussis; D002351:Carrageenan; D003907:Dexamethasone / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007213:Indomethacin / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D007978:Levamisole / Q000627:therapeutic use; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D013585:Synovitis / Q000188:drug therapy / Q000209:etiology / Q000276:immunology
D000893:Anti-Inflammatory Agents; D007978:Levamisole; D003907:Dexamethasone; D002351:Carrageenan; D010396:Penicillamine; D007213:Indomethacin