Inhibitory role of D-1 dopamine receptors for the jerks induced by B-HT 920 in rats.
Jerks of the head and upper trunk produced by the dopamine agonist B-HT 920 in reserpine-treated rats were abolished by the D-1 dopamine receptor agonist SKF 38393. The combined treatment with SKF 38393 and B-HT 920 instead resulted in stereotypies and locomotion. B-HT 920 also caused jerks when given after the D-1 receptor antagonist SCH 23390 to rats not pretreated with reserpine. The results indicate that B-HT 920 induces jerks by stimulation of postsynaptic D-2-like dopamine receptors provided that the D-1 receptors are not activated.
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001381:Azepines / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001552:Benzazepines / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D012110:Reserpine / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D014150:Antipsychotic Agents; D001381:Azepines; D001552:Benzazepines; D011954:Receptors, Dopamine; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; C024763:talipexole; D012110:Reserpine