[Serological study of the antibody to the adult T-cell leukemia-virus-associated antigen in various hematological diseases].
A serological study of antibody to adult T-cell leukemia-virus-associated antigen (anti-HTLV-I antibody) was made in 170 cases of various hematological diseases at Shikoku Cancer Center Hospital. The titer of anti-HTLV-I antibody was determined by indirect immunofluorescence using the MT-2 cell line. Two of two patients with ATL were positive for antibody. In non-Hodgkin's lymphoma, six of 18 cases of T-cell phenotype were positive (33%), while two of 29 cases of B-cell phenotype were antibody-positive (7%). Some cases of leukemia and aplastic anemia, who had received multiple blood transfusions, were found to be seropositive. Our results suggest that anti-HTLV-I antibody may be related to non-Hodgkin's lymphoma with T-cell phenotype as well as ATL.
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis*; D000956:Antigens, Viral / Q000276:immunology*; D006800:Deltaretrovirus Infections / Q000276:immunology*; D005260:Female; D015488:HIV Antigens; D006689:Hodgkin Disease / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology; D008297:Male; D008875:Middle Aged
D000914:Antibodies, Viral; D000956:Antigens, Viral; D015488:HIV Antigens