Urinary enzyme excretion after a single dose of phenacetin and paracetamol (acetaminophen) during antidiuresis and during water diuresis.
2 g phenacetin or paracetamol in a single oral dose were administered to five healthy persons under the conditions of antidiuresis and subsequent water diuresis. Excretion of the brush border enzyme GGT, the cytoplasm enzyme LDH, and the lysosomal enzymes, NAG and GAL, was analysed before, during and after ingestion of the analgesics. Increased excretion of LDH and GGT indicated a similar moderate damage of the tubular epithelia after phenacetin and paracetamol. The state of diuresis appeared to have no influence.
D000082:Acetaminophen / Q000494:pharmacology*; D000118:Acetylglucosaminidase / Q000652:urine; D004231:Diuresis; D004798:Enzymes / Q000652:urine*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D007770:L-Lactate Dehydrogenase / Q000652:urine; D007931:Leucyl Aminopeptidase / Q000652:urine; D010615:Phenacetin / Q000494:pharmacology*; D011897:Random Allocation; D014867:Water / Q000378:metabolism; D001616:beta-Galactosidase / Q000652:urine; D005723:gamma-Glutamyltransferase / Q000652:urine
D004798:Enzymes; D014867:Water; D000082:Acetaminophen; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001616:beta-Galactosidase; D000118:Acetylglucosaminidase; D007931:Leucyl Aminopeptidase; D010615:Phenacetin