title: Chemotherapy of East Coast fever. Treatment of infections induced by isolates of Theileria parva with halofuginone.
abstract: Cattle were infected with three isolates of Theileria parva and treated with halofuginone lactate during acute clinical disease. The health, weight gain and carrier state of the cattle were monitored for 15 months. Limited treatment rapidly reduced fever and parasitosis but parasite recrudescences occurred and 12 out of 21 treated cattle died. Persistent carrier states were identified with two T. p. parva isolate infections and a transient carrier state with T. p. lawrencei. Three cattle which died from a chronic wasting syndrome during the follow-up period showed exhaustion of lymph nodes but no Theileria macroschizonts were detected in any tissue.
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D001835:Body Weight; D002353:Carrier State / Q000188:drug therapy / Q000662:veterinary; D002417:Cattle; D007958:Leukocyte Count / Q000662:veterinary; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D010880:Piperidines; D011799:Quinazolines / Q000627:therapeutic use*; D052999:Quinazolinones; D013801:Theileriasis / Q000188:drug therapy*; D013987:Ticks
chemical_list: D000981:Antiprotozoal Agents; D010880:Piperidines; D011799:Quinazolines; D052999:Quinazolinones; C010176:halofuginone