Hepatic bile and pancreatic exocrine secretions evoked by gastrointestinal peptides in sheep.
The secretory response of hepatic bile and exocrine pancreas to gastrointestinal peptides has been studied in chronically cannulated sheep. Pancreatic juice flow and protein output were evoked dose dependently by intraportal injection of secretin, CCK-8, caerulein, VIP and neurotensin. However, biliary secretion was evoked by only secretin. Biliary and pancreatic exocrine secretions were enhanced by delivered gastric juice into the duodenum as followed by the increased plasma concentration of immunoreactive secretin (IRS). Results suggest that secretin is the major peptide that regulates pancreatic exocrine secretion and hepatic bile production in the sheep.
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism*; D002108:Ceruletide / Q000494:pharmacology; D005750:Gastric Juice / Q000502:physiology; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D009496:Neurotensin / Q000494:pharmacology; D010189:Pancreatic Juice / Q000187:drug effects / Q000378:metabolism*; D012633:Secretin / Q000494:pharmacology; D012756:Sheep; D012844:Sincalide / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D005768:Gastrointestinal Hormones; D012633:Secretin; D014660:Vasoactive Intestinal Peptide; D009496:Neurotensin; D002108:Ceruletide; D012844:Sincalide