title: Species specificity in cell-substrate interactions in medusae.
abstract: A new system is described for the study of ECM-tissue interactions, using the ECM (called mesogloea) of various cnidarians and isolated striated muscle and endodermal tissue of jellyfish. The mesogloea consists mainly of water and collagen. It is present in all cnidarians and can be isolated without enzyme treatment. It can be used as a substrate to which cells and tissues adhere and on which they spread and migrate. Tissues of striated muscle and endoderm adhere and spread not only on mesogloea from regions they normally cover, but also from other regions of the animal. However, adhesion and spreading are highly species-specific. Species-specific adhesion is found throughout the whole mass of mesogloea even at regions where cells do not occur naturally. The cell adhesion factor can be extracted from the mesogloea so that the mesogloea no longer shows any cell adhesion properties. The extract consists mainly of a cysteine-containing collagen.
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D003063:Cnidaria / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology*; D009132:Muscles / Q000166:cytology; D037401:Scyphozoa / Q000166:cytology / Q000502:physiology*; D013045:Species Specificity; D014020:Tissue Extracts
chemical_list: D014020:Tissue Extracts