title: Evaluation of sinefungin for the treatment of Trypanosoma (Nannomonas) congolense infections in goats.
abstract: Caprine Trypanosoma (N.) congolense infections were treated with sinefungin, an antifungal antibiotic nucleoside. Single doses from 10 to 20 mg/kg bodyweight given intramuscularly were not curative for goats; single doses of 25 and 50 mg/kg were toxic, and caused death. Five and 7.5 mg/kg administered twice daily over a three-day period, resulted in a cure in 2 animals, while 2 others relapsed. All animals relapsed when given a single daily dose of 5 or 7.5 mg/kg for 4 consecutive days. When such doses were given twice a day, they caused death in 50% of the goats and the remainder were cured. Raised serum urea levels indicated the severe nephrotoxic side-effects of sinefungin even at subcurative levels. Histopathological examinations revealed an acute tubulonephrosis.
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D004334:Drug Administration Schedule; D004341:Drug Evaluation / Q000662:veterinary; D005260:Female; D006041:Goats / Q000469:parasitology*; D007668:Kidney / Q000187:drug effects; D008297:Male; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D014348:Trypanosoma congolense; D014353:Trypanosomiasis, African / Q000188:drug therapy* / Q000662:veterinary*; D014508:Urea / Q000097:blood
chemical_list: D014344:Trypanocidal Agents; D014508:Urea; D000241:Adenosine; C006235:sinefungin