Comparison of preventive use of metronidazole and ampicillin in women with a history of pelvic inflammatory disease undergoing first-trimester abortion.
In a double-blind controlled trial the efficacy of prophylactic metronidazole and pivampicillin to women with a history of pelvic inflammatory disease (PID) undergoing first-trimester abortion was assessed. Thirty-eight women received pivampicillin tablets 350 mg and 43 women metronidazole tablets 400 mg, given 1 h before and 4 and 8 h after the abortion. In the pivampicillin group 5 women (13.1%) and in the metronidazole group 8 women (18.6%) developed post-abortal PID, a non-significant difference (P greater than 0.05). The number of hospital days and amounts of antibiotics were not significantly different in the two treatment groups (all P-values greater than 0.05). Women with a history of PID were found to be at risk of contracting postabortal PID.
D000028:Abortion, Induced / Q000009:adverse effects*; D000328:Adult; D000667:Ampicillin / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use*; D000292:Pelvic Inflammatory Disease / Q000517:prevention & control*; D010917:Pivampicillin / Q000627:therapeutic use*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011292:Premedication
D010917:Pivampicillin; D008795:Metronidazole; D000667:Ampicillin