Phenotypic modification of human glioma and non-small cell lung carcinoma by glucocorticoids and other agents.
Glucocorticoids are cytostatic for human glioma grown at a high cell density in cell culture. The effect is not cytotoxic, appears to involve a modification of the cell surface, and has been detected with methyl prednisolone, dexamethasone, and beta-methasone. Glucocorticoids were also found to reduce malignancy-associated properties (plasminogen activator and endothelial mitogenesis) and enhance differentiation (glutamyl synthetase activity and high affinity GABA uptake). Cytostasis was also seen at high cell densities in non-small cell lung carcinoma with a concomitant reduction in plasminogen activator activity and endothelial mitogenesis. Preliminary data on surfactant production in A549 cells suggests that the repression of malignancy-associated properties is accompanied by an increase in cell differentiation. Treatment of the WIL adenocarcinoma gown as a xenograft in nude mice caused total cessation of growth and massive central necrosis in the tumor.
D001254:Astrocytoma / Q000473:pathology; D001923:Brain Chemistry; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology*; D002460:Cell Line; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D005910:Glioma / Q000473:pathology*; D005938:Glucocorticoids / Q000494:pharmacology*; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008938:Mitosis / Q000187:drug effects; D010641:Phenotype; D010960:Plasminogen Activators / Q000494:pharmacology; D014020:Tissue Extracts / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D006063:Chorionic Gonadotropin; D005938:Glucocorticoids; D014020:Tissue Extracts; D003609:Dactinomycin; D005680:gamma-Aminobutyric Acid; D003907:Dexamethasone; D010960:Plasminogen Activators; D005974:Glutamate-Ammonia Ligase