Effects of kynurenic acid on evoked extracellular field potentials in the rat olfactory bulb in vivo.
The effects of excitatory amino acid antagonists on extracellular field potentials in the olfactory bulb produced by lateral olfactory tract stimulation were analyzed in vivo. The two compounds tested, D-2-amino-5-phosphonovalerate and kynurenic acid, were administered by brain dialysis. Only kynurenic acid was able to effectively suppress the monosynaptic excitation of the major class of interneurons, the granule cells. This pharmacological profile suggests the involvement of non-NMDA receptors.
D015763:2-Amino-5-phosphonovalerate; D000818:Animals; D005071:Evoked Potentials / Q000187:drug effects; D007736:Kynurenic Acid / Q000494:pharmacology*; D008297:Male; D009830:Olfactory Bulb / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
D017981:Receptors, Neurotransmitter; D015763:2-Amino-5-phosphonovalerate; D007736:Kynurenic Acid; D014633:Valine