Gossypol: a potent inhibitor of PAF-acether- and leukotriene-induced contractions of guinea-pig lung parenchyma strips.
Gossypol, a substance extracted from cotton plants, markedly inhibited the contractile responses of guinea-pig lung parenchyma strips stimulated with leukotriene B4 (LTB4), leukotriene D4 (LTD4) and PAF-acether but not the responses to histamine (except at high concentration). It was slightly less potent than nordihydroguaiaretic acid (NDGA) and a PAF-antagonist (BN 52021). From previously reported effects of gossypol on the cyclooxygenase and lipoxygenases, and on the similarity of the inhibition produced by NDGA and gossypol on the lung parenchyma, it is suggested that the inhibition of the myotropic activity of the lung parenchyma by gossypol is due to interactions with the formation of cyclooxygenase products within the guinea-pig lung.
D000818:Animals; D004224:Diterpenes; D046934:Ginkgolides; D006072:Gossypol / Q000494:pharmacology*; D006168:Guinea Pigs; D006633:Histamine Antagonists; D066298:In Vitro Techniques; D007783:Lactones; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors; D008168:Lung / Q000187:drug effects*; D008297:Male; D009637:Masoprocol / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D012132:Respiratory Muscles / Q000187:drug effects; D013189:SRS-A / Q000037:antagonists & inhibitors*
D004224:Diterpenes; D046934:Ginkgolides; D006633:Histamine Antagonists; D007783:Lactones; D010936:Plant Extracts; D010972:Platelet Activating Factor; D013189:SRS-A; D007975:Leukotriene B4; D009637:Masoprocol; C045856:ginkgolide B; D006072:Gossypol