Transglutaminase activity and embryonal carcinoma cell differentiation.
Murine embryonal carcinoma (EC) cells induced to differentiate by retinoic acid (RA) modulate transglutaminase (TGase) activity shortly after exposure to the inducer. Compounds that inhibit TGase enzyme activity in vitro can successfully block RA induced EC cell differentiation in culture. These observations suggest that TGase may play a role in mediating RA induced EC cell differentiation.
D000818:Animals; D002103:Cadaverine / Q000494:pharmacology; D002454:Cell Differentiation; D002460:Cell Line; D003538:Cystamine / Q000494:pharmacology; D007700:Kinetics; D051379:Mice; D013724:Teratoma / Q000201:enzymology / Q000473:pathology*; D011503:Transglutaminases / Q000378:metabolism*
D011503:Transglutaminases; D002103:Cadaverine; D003538:Cystamine