Effect of combined H-1 and H-2 histamine receptor antagonists on late asthmatic response in an asthmatic patient.
A curious inhibitory effect of histamine H-1 and H-2 antagonists on isolated late asthmatic response (LAR) in an asthmatic patient was observed. When given alone, neither the H-1 nor the H-2 antagonist had an effect on LAR. The combination of drugs, however, provided marked inhibition of LAR. These findings suggest that histamine contributes to some types of LAR.
D001249:Asthma / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology; D002744:Chlorpheniramine / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D004359:Drug Therapy, Combination; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012882:Skin Tests
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D007073:Immunoglobulin E; D002744:Chlorpheniramine; D002927:Cimetidine