[Demonstration of seasonal changes of circadian rhythms of amikacin chrononephrotoxicity in rats].
The present study investigates the chronobiological approach of the amikacin-induced nephrotoxicity in rats treated with a single sublethal dose administered at different times of day. The nephrotoxicity is appreciated by gamma-glutamyl-transferase and N-acetyl-beta-D-glucosaminidase urinary excretion, respectively a brush border and a lysosomal enzyme. These excretions peak out at 14:00 and reach a through at 20:00. In contrast, in a precedent experimentation, in october/november, we evidence gamma-glutamyl-transferase excretion increased at 20:00. So, we evidenced with amikacin not only a circadian but also a seasonal susceptibility in rats.
D000118:Acetylglucosaminidase / Q000652:urine*; D000583:Amikacin / Q000633:toxicity*; D000818:Animals; D002909:Chronobiology Phenomena; D002940:Circadian Rhythm; D004796:Clinical Enzyme Tests; D006596:Hexosaminidases / Q000652:urine*; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012621:Seasons; D005723:gamma-Glutamyltransferase / Q000652:urine*
D000583:Amikacin; D005723:gamma-Glutamyltransferase; D006596:Hexosaminidases; D000118:Acetylglucosaminidase
Mise en évidence des variations saisonnières des rythmes circadiens de la chrononéphrotoxicité de l'amikacine chez le rat.