title: The use of apolipoprotein CII as a genetic marker for myotonic dystrophy.
abstract: In five families we have confirmed the close linkage between the genes for myotonic dystrophy and apolipoprotein CII. The total maximum lod (log of the odds) score was 3.32 at 0 recombination. We demonstrate that the use of a Ban I restriction site polymorphism for apolipoprotein CII adds additional useful information when combined with the more commonly used Taq I polymorphism. The potential practical clinical use of these markers for the prenatal diagnosis of myotonic dystrophy is demonstrated.
mesh_terms: D053304:Apolipoprotein C-II; D001056:Apolipoproteins C / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D009223:Myotonic Dystrophy / Q000235:genetics*; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D053304:Apolipoprotein C-II; D001056:Apolipoproteins C; D005819:Genetic Markers