Non-ionic surfactant vesicles, niosomes, as a delivery system for the anti-leishmanial drug, sodium stibogluconate.
Liver and serum concentrations of antimony in the mouse have been determined after administration of sodium stibogluconate in the free, liposomal and niosomal form. High liver and low serum values were attained by the use of both vesicular formulations. Niosomal sodium stibogluconate was shown to be more active than free drug against experimental murine visceral leishmaniasis, an effect apparently dependent on maintaining high drug levels in the infected reticuloendothelial system.
D000818:Animals; D000965:Antimony / Q000097:blood / Q000378:metabolism; D000967:Antimony Sodium Gluconate / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D005942:Gluconates / Q000008:administration & dosage*; D007700:Kinetics; D007893:Leishmania donovani / Q000187:drug effects*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008823:Micelles; D014677:Pharmaceutical Vehicles; D013501:Surface-Active Agents; D014018:Tissue Distribution
D005942:Gluconates; D008823:Micelles; D014677:Pharmaceutical Vehicles; D013501:Surface-Active Agents; D000965:Antimony; D000967:Antimony Sodium Gluconate