Intracerebral SCH 23390 and catalepsy in the rat.
Stereotaxic injection of SCH 23390 (D-1 antagonist), but not water or ritanserin (5-HT antagonist), into all parts of the caudate-putamen, elicited an immediate and often long-lasting catalepsy in 79% of rats. Similar results were obtained with SCH 23390 delivered into the nucleus accumbens and globus pallidus, but not into a variety of other brain sites. The results support the idea that SCH 23390-induced catalepsy is related to the occlusion of dopamine D-1 receptors in the forebrain, particularly the striatum, although the topography of the catalepsy evoked by intrastriatal SCH 23390 did not match the distribution of D-1 sites labelled in autoradiographic studies.
D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001552:Benzazepines / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain; D002375:Catalepsy / Q000139:chemically induced*; D003342:Corpus Striatum; D005260:Female; D007267:Injections; D007279:Injections, Subcutaneous; D051381:Rats; D011919:Rats, Inbred Strains
D014150:Antipsychotic Agents; D001552:Benzazepines