Pharmacokinetics of kanamycin in the bullfrog, Rana catesbeiana.
1. Kanamycin disposition was studied in bullfrogs (Rana catesbeiana) following single doses IP. Both plasma t1/2 and Vd of the drug increased with increasing time after drug indicating redistribution and tight binding of kanamycin to deep tissue compartments. 2. Kanamycin was eliminated unchanged with a t1/2 plasma = 27 hr; perilymph = 89 hr; endolymph = 183 hr; aqueous humor = 54 hr; and CSF = 58 hr. 3. Kanamycin was absorbed by frogs from environmental water. 4. Environmental conditions must be carefully specified and monitored, as well as the physiological state of the animals when studying the effects of drugs on Amphibia.
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D004710:Endolymph / Q000378:metabolism; D006207:Half-Life; D007612:Kanamycin / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D010498:Perilymph / Q000378:metabolism; D011892:Rana catesbeiana / Q000378:metabolism*
D007612:Kanamycin