[Influence of klofelin on the analgesic and autonomotropic effects of narcotic analgesics].
In conscious rats clopheline (0.1-0.25 mg/kg), in contrast to promedol, morphine and fentanyl administered at analgesic doses, suppressed nociceptive reactions of arterial blood pressure produced by a mechanical stimulation and intracardiac infusion of bradykinin. The use of clopheline in combination with narcotic analgesics potentiated the analgesic effect and significantly inhibited nociceptive hemodynamic reactions without changing the background level of arterial blood pressure.
D000700:Analgesics / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006321:Heart / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects; D051381:Rats; D014851:Wakefulness / Q000187:drug effects
D000700:Analgesics; D000701:Analgesics, Opioid; D003000:Clonidine; D001920:Bradykinin
Vliianie klofelina na boleutoliaiushchiĭ i vegetotropnyĭ éffekty narkoticheskikh anal'getikov.