[Is Alzheimer's senile dementia associated with the phenomena of reactive synaptogenesis in the hippocampus?].
The densities of specific binding sites for glutamate or its analogue kainate were determined in the hippocampi of patients having suffered of senile dementia of the Alzheimer type (SDAT) and compared to age matched controls. The densities of sites were reduced in SDAT cases. These results indicate a lack of hippocampal plasticity in senile dementia of Alzheimer type.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology* / Q000503:physiopathology; D001345:Autoradiography; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007608:Kainic Acid / Q000378:metabolism; D008875:Middle Aged; D009473:Neuronal Plasticity; D017981:Receptors, Neurotransmitter / Q000032:analysis* / Q000378:metabolism
D005971:Glutamates; D017981:Receptors, Neurotransmitter; D018698:Glutamic Acid; D007608:Kainic Acid
La démence sénile d'Alzheimer est-elle associée à des phénomènes de synaptogenèse réactive au niveau de l'hippocampe?