[Role of hypothalamic histaminergic systems in the regulation of vigilance states in cats].
We have studied the effects of local injections of histaminergic and antihistaminic drugs on the sleep-waking cycle in the cat. Microinjections of alpha-fluoromethylhistidine (alpha-FMH), a specific inhibitor of histidine decarboxylase, in the ventrolateral posterior hypothalamus, where histamine-immunoreactive neurons have been recently identified, resulted in a significant decrease in wakefulness (W) and increase in deep slow wave sleep (SWS). On the other hand, microinjections of SKF-91488 (Homodimaprit), a specific inhibitor of histamine-N-methyltransferase, increased W and decreased SWS and paradoxical sleep (PS). Microinjections of histamine also produced an increase of W, while this effect was abolished by pretreatment with mepyramine, an H1-histamine receptor antagonist.
D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000502:physiology*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D006632:Histamine / Q000494:pharmacology / Q000502:physiology*; D006633:Histamine Antagonists / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D007031:Hypothalamus / Q000502:physiology*; D007034:Hypothalamus, Posterior / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D006633:Histamine Antagonists; D006634:Histamine H1 Antagonists; D006632:Histamine
Rôle des systèmes histaminergiques hypothalamiques dans la régulation des états de vigilance chez le chat.