Pharmacological studies of somatostatin and somatostatin-analogues: therapeutic advances and perspectives.
This article is aimed at reviewing and analyzing studies that are related to the possible therapeutic use of a potent and ubiquitously-distributed hormone--somato-statin (SS-14), and its analogues. Administration of these substances has provided beneficial effects in treating acromegaly, gastro-intestinal hemorrhagic and hypersecretory disorders, acute pancreatitis, diabetes mellitus, and certain types of cancer. Further studies with SS-14-analogues might provide new therapies for treating certain life-threatening disorders of man.
D000172:Acromegaly / Q000188:drug therapy; D000544:Alzheimer Disease / Q000188:drug therapy; D004815:Epidermal Growth Factor / Q000037:antagonists & inhibitors; D005767:Gastrointestinal Diseases / Q000188:drug therapy; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D010182:Pancreatic Diseases / Q000188:drug therapy; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*
D013004:Somatostatin; D004815:Epidermal Growth Factor