Testosterone, androstenedione, progesterone and 17 alpha-hydroxyprogesterone in plasma and testes of immature rats under basal conditions and after hCG stimulation. Effect of bilateral cryptorchidism.
Rats were made bilaterally cryptorchid at 21 days of age; sham-operated rats were used as controls. At 35 days, the animals were injected i.m. with saline or with 10 IU hCG. Progesterone, 17-hydroxyprogesterone, androstenedione and testosterone were measured in both testes and plasma under basal conditions and 2, 4, 8, 12, 24 and 72 h respectively after injection. The plasma levels and intratesticular contents of the steroids were generally lower in cryptorchid rats. The patterns of the steroid response to hCG were similar in both groups: in the testes and in the plasma, they increased acutely following hCG injection (except testicular androstenedione), then, after 72 h, returned to normal values in the plasma but remained higher than the basal values in the testes. These results suggest that there are no gross abnormalities in the testicular steroidogenic pathways and that the mechanism of action of hCG on the Leydig cells is unaltered in bilaterally cryptorchid immature rats.
D019326:17-alpha-Hydroxyprogesterone; D000735:Androstenedione / Q000032:analysis*; D000818:Animals; D006063:Chorionic Gonadotropin / Q000097:blood / Q000494:pharmacology*; D003456:Cryptorchidism / Q000378:metabolism*; D006908:Hydroxyprogesterones / Q000032:analysis*; D008297:Male; D011374:Progesterone / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000032:analysis* / Q000187:drug effects; D013739:Testosterone / Q000032:analysis*
D006063:Chorionic Gonadotropin; D006908:Hydroxyprogesterones; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; D019326:17-alpha-Hydroxyprogesterone