title: Quantitative structure-activity relationships. Fujita-Ban analysis of beta-adrenergic blocking activity of 1-phenoxy-3-([(substituted amido)alkyl]amino)-2-propanols.
abstract: Quantitative structure-activity relationship studies have been performed in a series of 81 beta-adrenergic blocking 1-phenoxy-3-([substituted amido)alkyl] amino)-2-propanols using the Fujita-Ban model. A correlation significant at p less than 0.0005 (r = 0.883, F46,34 = 2.60) was obtained using 46 independent substituents. The set of independent substituents has been successfully contracted to 36 substituents (F 36,44 = 4.26). On the basis of the calculated group contributions the derivatives with high predicted activity have been proposed.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis*; D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D011412:Propanolamines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000319:Adrenergic beta-Antagonists; D000577:Amides; D011412:Propanolamines