Granular cell tumors: evidence for heterogeneous tumor cell differentiation. An immunocytochemical study.
Eighteen granular cell tumors from various sites were examined with antisera directed against protein S-100, neuron specific enolase (NSE), alpha-1-antichymotrypsin, and alpha-1-antitrypsin, glial fibrillary acidic protein (GFAP), lysozyme, factor VIII-related antigen, myoglobin and vimentin, as well as with a monoclonal antibody (lu-5) directed against a panepithelial marker. The immunocytochemical reaction pattern of the tumors was heterogeneous. The brain and pituitary tumors and one thyroid tumor reacted for alpha-1-antichymotrypsin and alpha-1-antitrypsin, but not for S-100 protein and NSE. However, tumors from other sites showed immunoreactions for S-100 protein and NSE and some also for vimentin. Reactions for alpha-1-antichymotrypsin and alpha-1-antitrypsin were not observed. All other reactions were similarly negative. We conclude that the morphologically homogeneous group of granular cell tumors is biologically heterogeneous.
D002454:Cell Differentiation; D004848:Epithelium / Q000473:pathology; D005169:Factor VIII / Q000032:analysis; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D009113:Muramidase / Q000032:analysis; D009211:Myoglobin / Q000032:analysis; D009379:Neoplasms, Muscle Tissue / Q000276:immunology / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D011480:Protease Inhibitors / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis
D005904:Glial Fibrillary Acidic Protein; D009211:Myoglobin; D011480:Protease Inhibitors; D009418:S100 Proteins; D014746:Vimentin; D005169:Factor VIII; D009113:Muramidase; D010751:Phosphopyruvate Hydratase