title: [Metipranolol 0.1%: effect of a single dose on the nycthemeral pressure curve in an eye with chronic primary open-angle glaucoma].
abstract: A double blind randomised study was made to compare the efficiency in decreasing intra ocular pressure of Metipranolol 0.1% or 0.3% versus placebo in three groups of 15 patients with chronic open angle glaucoma with or without visual field defects. The results demonstrate that Metipranolol 0.1% significantly lowers the intra ocular pressure in comparison with placebo. But this lowering is less that the one with 0.3% and is markedly reduced after 9 hours. The action of Metipranolol 0.3% is more durable and is still observed at 24 hours with a drop of nearly 20% in comparison with the initial intra ocular pressure. In the three groups, no significant variation of pulse and arterial pressure could be noticed during this 24 hours study.
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D002940:Circadian Rhythm; D004311:Double-Blind Method; D004341:Drug Evaluation; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D014290:Metipranolol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011412:Propanolamines / Q000494:pharmacology* / Q000627:therapeutic use*; D011897:Random Allocation; D013997:Time Factors
chemical_list: D009883:Ophthalmic Solutions; D011412:Propanolamines; D014290:Metipranolol
vernacular_title: Métipranolol 0.1%: l'effet d'une dose unique sur la courbe tensionnelle nycthémérale d'un oeil porteur d'un glaucome chronique primitif à angle ouvert.