[Prolonged use of beta-blockers in patients with essential hypertension and different degrees of severity of left ventricular hypertrophy].
The paper is concerned with analysis of the results of therapy with beta-blockers of different classes of 56 patients (over 2.5-3 yrs) with essential hypertension and analysis of the time course of the structural-functional states of the left ventricular myocardium with various degree of expression of left ventricular hypertrophy (LVH). The patients were divided into 3 groups: the 1st group--14 persons (the left ventricular myocardial mass/LVMM/up to 150 g); the 2nd group--19 persons (the LVMM up to 200 g); the 3rd group--23 persons (the LVMM over 200 g). Patients in all the groups showed a significant decrease in BP from 19/15 up to 26/22% (p less than 0.001), the cardiac index (CI) from 14.4 up to 18.5% (p less than 0.001), and HR from 16.5 to 19.1% (p less than 0.001). The stroke index (SI) did not change significantly. The total peripheral vascular resistance (TPVR) in all the groups showed a tendency to a decrease, in the 3rd group only it decreased significantly. In the patients of the 1st and 2nd groups end-systolic sizes (ESS) increased by 4.1 and 3.1% (p less than 0.05) and volumes (ESV) by 9.7 and 7.4% (p less than 0.05), and in the 3rd group a tendency to a decrease was observed. End-diastolic sizes and volumes in all the groups did not change significantly. The myocardial contractility index (VCF) decreased significantly in the 1st and 2nd groups of patients. The value of intramyocardial tension ("sigma max") decreased in all the groups from 15 to 20% (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D006332:Cardiomegaly / Q000150:complications* / Q000473:pathology; D004232:Diuretics / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D014665:Vasodilator Agents / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D004232:Diuretics; D014665:Vasodilator Agents
Dlitel'noe primenenie beta-blokatorov u bol'nykh gipertonicheskoĭ bolezn'iu s razlichnoĭ stepen'iu vyrazhennosti gipertrofii levogo zheludochka.