Effects of diltiazem on morphine-induced respiratory decline.
The individual and combined effects of subcutaneous morphine and diltiazem, a calcium channel inhibitor, on arterial blood gases and pH were assessed in conscious Fischer-344 rats. Morphine (4 mg kg-1) produced hypercapnia, hypoxia and slight acidosis, as compared with control values. Diltiazem (10 mg kg-1) alone did not affect these parameters; however, it significantly delayed the onset of the aforementioned effects of morphine.
D000818:Animals; D004110:Diltiazem / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D012119:Respiration / Q000187:drug effects; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000187:drug effects*
D009020:Morphine; D004110:Diltiazem