The role of adrenoceptors in the mechanism of reserpine-induced stimulation of gastric acid secretion in the rat.
The role of alpha- and beta-adrenoceptors in the mechanism of reserpine-induced stimulation of gastric acid secretion in the rat has been examined. After 6 h reserpine (0.1 mg kg-1 i.p.) significantly stimulated acid secretion relative to control values (176 +/- 4 vs 60 +/- 3 mumol, mean +/- s.e.m., n = 10, P less than 0.001). Neither coeliac ganglionectomy nor propranolol (5-15 mg kg-1) influenced this action. Vagotomy prevented acid stimulation by reserpine and was associated with H+ output similar to that of vagotomy controls (13 +/- 1 vs 14 +/- 1 mumol, mean +/- s.e.m., n = 10). Dose-dependent inhibition of the reserpine-induced acid secretion was produced by phenoxybenzamine or phentolamine; an inhibition similar to that achieved by vagotomy was noted with the 15 mg kg-1 dose (13 +/- 1 and 15 +/- 1 mumol, respectively, vs 176 +/- 4 mumol, mean +/- s.e.m., n = 10, P less than 0.001). The similarity in action between vagotomy and large doses of phenoxybenzamine or phentolamine suggests that, in the rat, vagal alpha-adrenoceptor stimulation is directly involved in the mechanism of reserpine-induced stimulation of gastric acid secretion.
D000818:Animals; D005260:Female; D005728:Ganglia, Sympathetic / Q000502:physiology; D005744:Gastric Acid / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000378:metabolism*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism; D012110:Reserpine / Q000008:administration & dosage / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014628:Vagotomy
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D012110:Reserpine