[Immunocytochemical study of catecholaminergic neurons in grafted mesencephalon transplanted into the hypothalamus of the rat].
Mesencephalic fragments from 14 day old embryonic rat brain were transplanted into the third ventricle of adult rats neonatally treated with monosodium glutamate. From two to twelve months after grafting, the implanted tissue was still present in the ventricle and contained TH immunoreactive neurons which displayed a normal appearance at ultrastructural level. While endogenous TH containing neurons were still present in dopaminergic regions of the recipient hypothalamus, grafted mesencephalic fragments could survive and develop. They contained TH immunopositive most probably dopaminergic neurons which are able, in some cases, to innervate the host brain. This model should be of interest in the study of neuroendocrine functions of dopaminergic neurons.
D000818:Animals; D002395:Catecholamines / Q000032:analysis; D007031:Hypothalamus / Q000166:cytology*; D007150:Immunohistochemistry; D008636:Mesencephalon / Q000166:cytology / Q000637:transplantation*; D009474:Neurons / Q000166:cytology* / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012970:Sodium Glutamate / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D002395:Catecholamines; D014446:Tyrosine 3-Monooxygenase; D012970:Sodium Glutamate
Etude immunocytochimique des neurones catécholaminergiques dans des greffons mésencéphaliques transplantés dans l'hypothalamus du rat.