Functional evidence for altered activity of GABAergic receptors following chronic desipramine treatment in rats.
The antinociceptive effect of subcutaneous 4,5,6,7-tetrahydroisoxazol[5,4-c]pyridin-3-ol (THIP) or (+/-)-baclofen, measured as reaction time of rats placed on a plate heated to 55 degrees C, was assessed after a single or the last repeated (18 consecutive days) dose (5 mg kg-1 once daily) of subcutaneous desipramine. Baclofen (10 mg kg-1)-induced antinociception was reduced by acute and unaffected by chronic desipramine treatment. On the contrary, THIP (20 mg kg-1)-induced antinociception was unaffected by acute and reduced by chronic desipramine.
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D003891:Desipramine / Q000494:pharmacology*; D007555:Isoxazoles / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000378:metabolism*
D000700:Analgesics; D007555:Isoxazoles; D011963:Receptors, GABA-A; D001418:Baclofen; C015542:gaboxadol; D003891:Desipramine