Respiration driven C1- uptake by submitochondrial particles.
Both Mg2+ and oligomycin are required for the establishment of a membrane potential and the uptake of Cl- in submitochondrial particles prepared from rat liver. The effect of oligomycin is considered to be due to blocking of H+ conduction through exposed F0 channels of the ATPase complex whereas Mg2+ may more directly affect the anion-conducting channel.
D000818:Animals; D002259:Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone / Q000494:pharmacology; D002712:Chlorides / Q000378:metabolism*; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D008564:Membrane Potentials; D009840:Oligomycins / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D006180:Proton-Translocating ATPases / Q000378:metabolism; D051381:Rats; D013367:Submitochondrial Particles / Q000378:metabolism*
D002712:Chlorides; D009840:Oligomycins; D002259:Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; D006180:Proton-Translocating ATPases; D008274:Magnesium