Food intake in rats is increased by intracerebroventricular infusion of the somatostatin analogue SMS 201-995 and is decreased by somatostatin antiserum.
The chronic intracerebroventricular infusion of the somatostatin analogue SMS 201-995 resulted in a significant increase in daily food intake which was accompanied by an unexpected body weight loss. The neutralisation of central somatostatin using a specific somatostatin antiserum resulted in a significant decrease in daily food intake. These results suggest that endogenous somatostatin in the brain can drive feeding behavior and alter body weight.
D000818:Animals; D001835:Body Weight; D002552:Cerebral Ventricles; D004435:Eating; D005247:Feeding Behavior / Q000187:drug effects*; D007106:Immune Sera; D007263:Infusions, Parenteral; D008297:Male; D015282:Octreotide; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000276:immunology / Q000494:pharmacology / Q000502:physiology*
D007106:Immune Sera; D013004:Somatostatin; D015282:Octreotide