Potent inhibitory effect of antibiotic 1233A on cholesterol biosynthesis which specifically blocks 3-hydroxy-3-methylglutaryl coenzyme A synthase.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000096:biosynthesis*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D006904:Hydroxymethylglutaryl-CoA Synthase / Q000037:antagonists & inhibitors*; D007783:Lactones / Q000494:pharmacology; D007652:Oxo-Acid-Lyases / Q000037:antagonists & inhibitors*; D051381:Rats
D000900:Anti-Bacterial Agents; D005231:Fatty Acids, Unsaturated; D007783:Lactones; C054282:antibiotic 1233A; D002784:Cholesterol; D006904:Hydroxymethylglutaryl-CoA Synthase; D007652:Oxo-Acid-Lyases