Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin.
The use of a noninvasive skin chamber technique in vivo in pollen-sensitive patients allowed us to quantify the time-course release of histamine and the recruitment of inflammatory cells (i.e., neutrophils, monocytes, and eosinophils) in skin sites challenged with pollen, histamine, and compound 48/80. The new H1-receptor antagonist, cetirizine 2 HCl, orally administered with 10 mg once a day to pollen-sensitive patients in a double-blind, crossover study versus placebo, induced a significant decrease in the wheal-and-flare cutaneous reaction induced by intradermal injection of pollen, histamine, and compound 48/80. It also significantly inhibited the immediate histamine release occurring in skin chambers after pollen introduction, whereas it did not significantly inhibit the late release. In patients receiving placebo, we detected platelet-activating factor-acether in media collected at the sixth hour from chambers filled with pollen. With cetirizine 2 HCl treatment, platelet-activating factor-acether was not detected in chamber media. Interestingly, cetirizine 2 HCl significantly reduced the eosinophil recruitment observed on the superficial dermis 24 hours after pollen challenge.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D017332:Cetirizine; D004804:Eosinophils / Q000187:drug effects*; D005260:Female; D006632:Histamine / Q000378:metabolism*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D006919:Hydroxyzine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006969:Hypersensitivity, Immediate / Q000378:metabolism; D008297:Male; D010972:Platelet Activating Factor / Q000378:metabolism*; D012867:Skin / Q000166:cytology* / Q000276:immunology
D006634:Histamine H1 Antagonists; D010972:Platelet Activating Factor; D006919:Hydroxyzine; D006632:Histamine; D017332:Cetirizine