Allelic variation of the c-raf-1 oncogene in non-Hodgkin's lymphoma.
Polymorphic variation of the c-raf-1 proto-oncogene is reported here for the first time. In a study of 21 individuals, including 17 with non-Hodgkin's lymphoma and three healthy controls, we have identified three c-raf-1 alleles. One variant allele was observed in both a mother and her son, both of whom had lymphoma, but in no other case. The other variant allele was observed in two patients with lymphoma and in a healthy control.
D000483:Alleles; D002883:Chromosomes, Human, Pair 14; D002893:Chromosomes, Human, Pair 3; D004273:DNA, Neoplasm / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D009857:Oncogenes; D012150:Polymorphism, Restriction Fragment Length; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D014178:Translocation, Genetic
D004273:DNA, Neoplasm; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger; D012334:RNA, Neoplasm