title: [Morphofunctional state of the APUD-system cells of the lungs in hyaline membrane disease of newborn infants].
abstract: Examination of these cells in newborn infants with hyaline membrane disease. (HMD) has demonstrated involvement of neuroendocrine elements in its patho- and morphogenesis. A crucial factor in HMD development is immaturity of the lungs, one sign of which is the presence of numerous serotonin-containing cells. Degranulation of APUD cells and serotonin lease under exposure to pathogenic factors initiate pathologic reactions in the lungs and account for the earliest manifestations of the disease.
mesh_terms: D001078:APUD Cells / Q000473:pathology* / Q000502:physiology; D002452:Cell Count; D005325:Fetal Organ Maturity; D006651:Histocytochemistry; D006801:Humans; D006819:Hyaline Membrane Disease / Q000196:embryology / Q000209:etiology / Q000473:pathology*; D007231:Infant, Newborn; D007234:Infant, Premature; D008168:Lung / Q000196:embryology / Q000378:metabolism / Q000473:pathology*; D012701:Serotonin / Q000378:metabolism
chemical_list: D012701:Serotonin
vernacular_title: Morfofunktsional'noe sostoianie kletok APUD-sistemy legkikh pri bolezni gialinovykh membran novorozhdennykh deteĭ.