Contractile activity of calcitonin gene-related peptide on pulmonary tissues.
Rat calcitonin gene-related peptide was shown to be a very potent contractile agent on guinea-pig trachea, contractions being observed at 10 pM and maximal contractions (32-36% of the methacholine maximum) being observed between 0.3 and 13.3 nM. The response was largely inhibited (88%) by pretreatment with indomethacin indicating that the effect was mediated through the secondary generation of cyclooxygenase products.
D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008168:Lung / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009479:Neuropeptides / Q000494:pharmacology*; D051381:Rats; D014132:Trachea / Q000187:drug effects
D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide; D007213:Indomethacin