Some features of age-related insulin responsiveness in rat hepatocytes.
Different features of insulin sensitivity have been considered, in rat hepatocytes, with respect to their age-dependence. In particular, plasma membrane-located responses such as (Na/K)-ATPase and Na-dependent aminoacid transport were studied together with cytoplasmic responses such as the insulin-stimulated tyrosine aminotransferase. It appears, as far as the insulin sensitivity is concerned, that the age of the animal does not affect plasma membrane-bound events whereas plasma membrane-mediated intracellular responses are definitely impaired. Insulin binding to intact hepatocytes does not seem to be age-dependent.
D000375:Aging / Q000378:metabolism*; D000621:Aminoisobutyric Acids / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000502:physiology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014444:Tyrosine Transaminase / Q000378:metabolism
D000621:Aminoisobutyric Acids; D007328:Insulin; D014444:Tyrosine Transaminase; D011972:Receptor, Insulin; D000254:Sodium-Potassium-Exchanging ATPase; D004837:Epinephrine