[2-Deoxyglucose as a tool for analyzing the humoral component of the cardiovascular reaction to stress].
Blood pressure (BP), heart rate (HR), adrenaline (A) and noradrenaline (NA) effects of 2-desoxyglucose (500 mg/kg i.v.) were studied in conscious chronically instrumented wistar rats. A and NA contents in the blood were estimated by HPLC with electrochemical detection. In 15-40 minutes after 2-DG administration it was 13-16-fold increase in A content, 1.7-1.9-fold increase in NA content. At the same time BP fell by 5 mm Hg and HR fell by 100 beats/min. Atropine blocked bradycardia but had no effect on BP. It is concluded that high levels of endogenous A during stress are not responsible for cardiovascular responses usually observed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D004837:Epinephrine / Q000097:blood; D005947:Glucose / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D018377:Neurotransmitter Agents / Q000097:blood*; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000097:blood / Q000503:physiopathology*; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology
D003837:Deoxy Sugars; D018377:Neurotransmitter Agents; D003847:Deoxyglucose; D005947:Glucose; D009638:Norepinephrine; D004837:Epinephrine
2-Deoksigliukoza kak instrument analiza gumoral'nogo komponenta reaktsii serdechno-sosudistoĭ sistemy na stress.