Influence of sexual differentiation on striatal and limbic catecholamines.
The influence of sexual differentiation of the brain on catecholamine content in the corpus striatum and limbic system was studied. Our results suggest that circulating ovary hormones during the critical period play an important role in the sexual differentiation of dopaminergic neurons in the corpus striatum and limbic system. Absence of androgenic steroids in the critical period leads to permanent alterations in the DA content of the limbic system in the male rat. Gonadectomy does not significantly alter NA levels in either of the two studied brain areas.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008032:Limbic System / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D009919:Orchiectomy; D010052:Ovariectomy; D051381:Rats; D012733:Sex Differentiation; D013739:Testosterone / Q000494:pharmacology*
D002395:Catecholamines; D013739:Testosterone; D004958:Estradiol; D004298:Dopamine; D009638:Norepinephrine