The spectrum of hepatotoxicity due to drugs.
Drugs in common use can cause toxic effects on the liver which can mimic almost every naturally occurring liver disease in man. Drugs can have direct (metabolite-related) toxic effects; they can also cause deposition of microvesicular fat in hepatocytes; or they can provoke reactions resembling acute alcoholic hepatitis (phospholipidosis) or acute viral hepatitis. Hepatotoxicity can also be part of a general hypersensitivity reaction, or hepatic fibrosis or cholestasis can predominate. Drugs can lead to almost any type of vascular disease in the liver and to benign and malignant tumours.
D000208:Acute Disease; D000236:Adenoma / Q000139:chemically induced; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002648:Child; D002779:Cholestasis / Q000139:chemically induced; D002908:Chronic Disease; D004342:Drug Hypersensitivity / Q000209:etiology; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000139:chemically induced; D008875:Middle Aged; D004364:Pharmaceutical Preparations / Q000378:metabolism
D004364:Pharmaceutical Preparations