Somatostatin in multiple sclerosis.
The detection of somatostatin, a 14 aminoacid peptide, in human brain and cerebrospinal fluid (CSF) initiated examinations by radioimmunoassay and immunocytochemical technique to elucidate its origin, localization, function, and possible significance in central nervous system disorders. The present survey deals with these aspects with special reference to multiple sclerosis (MS) and to correlation between disease activity and somatostatin content and variations in CSF.
D000818:Animals; D001921:Brain / Q000378:metabolism; D013006:Growth Hormone / Q000134:cerebrospinal fluid; D006801:Humans; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000378:metabolism; D013004:Somatostatin / Q000134:cerebrospinal fluid* / Q000378:metabolism
D013004:Somatostatin; D013006:Growth Hormone