Genetic linkage map of human chromosome 7 with 63 DNA markers.
High-density genetic maps of individual human chromosomes will permit accurate localization of disease-associated genes and provide signposts that will be useful in the construction of physical maps. We have constructed a genetic map of chromosome 7 with 63 polymorphic DNA markers by using segregation data from 23 three-generation families and recently developed multilocus linkage-analysis techniques. The map spans 250 centimorgans in females and 170 centimorgans in males, with much of the difference being concentrated in a few intervals. The density and informativeness of the markers are such that there is a high probability of detecting linkage to any disease gene on this chromosome for which 20 phase-known meioses are available.
D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D004274:DNA, Recombinant; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D004274:DNA, Recombinant; D005819:Genetic Markers