Pharmacologically induced changes in the latency of digastric reflexes in 1-7 day old rabbits.
1. The naturally occurring change in latency of the digastric reflex from long (40-70 msec) to short (15-35 msec) in the first week of life was studied in rabbits using drugs known to affect GABAergic and glycinergic transmission. 2. Usually the long or the short latency reflex response appeared alone but after strychnine both appeared together. 3. The long latency responses were favoured by the GABA blockers bicuculline and picrotoxin; periodically rhythmic activity was also elicited. 4. The short latency responses were favoured by the GABA agonists pentobarbitone and diazepam.
D000818:Animals; D000831:Animals, Newborn; D001640:Bicuculline / Q000494:pharmacology; D003655:Decerebrate State; D003975:Diazepam / Q000494:pharmacology; D004576:Electromyography; D010424:Pentobarbital / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D011817:Rabbits; D012018:Reflex / Q000187:drug effects*; D013270:Stomach / Q000187:drug effects* / Q000502:physiology; D013331:Strychnine / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D001640:Bicuculline; D003975:Diazepam; D010424:Pentobarbital; D010852:Picrotoxin; D013331:Strychnine; D005680:gamma-Aminobutyric Acid