title: Search for a gene that predisposes individuals to BPI disorder.
abstract: To determine the role of genetics in bipolar affective disorders it was necessary to have correct diagnoses and large homogenous population(s). To identify a marker linked to the disease two additional factors were important, a correct model for genetic transmission and highly polymorphic DNA markers. With the establishment of a linked marker the aim is to identify the susceptibility gene. Two approaches are the prediction of candidate genes and/or the determination of a physical map of the region.
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics
chemical_list: D005819:Genetic Markers; D014446:Tyrosine 3-Monooxygenase