The influence of chlormethiazole in comparison to thioridazine on body temperature and postural hypotension in healthy adults and healthy elderly volunteers.
Certain drugs used to treat the elderly are known to precipitate hypothermia. In this study, the effects of chlormethiazole and thioridazine in producing postural hypotension were compared. In a study of hypothermia in the elderly the effects of chlormethiazole, thioridazine and lormetazepam were examined. Only three patients showed a postural drop following chlormethiazole, while 11 showed a postural drop following thioridazine. Chlormethiazole showed little variation from the control group in the hypothermia study, while thioridazine and lormetazepam caused a fall in temperature. For behaviour control in the elderly and for a short course as a hypnotic, chlormethiazole seems to be safer than thioridazine or lormetazepam.
D000328:Adult; D000367:Age Factors; D000368:Aged; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001569:Benzodiazepines; D001794:Blood Pressure / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects*; D002719:Chlormethiazole / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D011187:Posture; D012881:Skin Temperature / Q000187:drug effects; D013881:Thioridazine / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D002719:Chlormethiazole; D001569:Benzodiazepines; C023842:lormetazepam; D013881:Thioridazine; D008140:Lorazepam