Toxicity of p-methoxyphenol to dopamine neurons in the rat substantia nigra.
Local injections of p-methoxyphenol into the substantia nigra of rats led to a mildly dose-related destruction of dopamine neurons as indicated by reductions of dopamine and its metabolites in the ipsilateral striatum and by loss of tyrosine hydroxylase immunoreactivity in the injected substantia nigra. Both Nissl staining of the injected nucleus and measurement of noradrenaline and serotonin in the ipsilateral striatum indicated some selectivity of the toxic action.
D000818:Animals; D000840:Anisoles / Q000633:toxicity*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D013378:Substantia Nigra / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D000840:Anisoles; D011954:Receptors, Dopamine; C009760:mequinol; D014446:Tyrosine 3-Monooxygenase