Antipsychotic drugs: prediction of side-effect profiles based on neuroreceptor data derived from human brain tissue.
The affinities of antipsychotic agents for neurotransmitter receptors are believed to be responsible for their antipsychotic activity and side-effect profiles. Data on neuroreceptor affinity can be used to predict side-effect profiles of antipsychotic drugs. In this report, we present data on receptor affinity that have been modified to help clinicians clearly see the potential for each drug to produce a specific side effect at any dosage.
D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000378:metabolism; D001923:Brain Chemistry; D006801:Humans; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000378:metabolism*; D011968:Receptors, Histamine / Q000378:metabolism*; D011969:Receptors, Histamine H1 / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism*
D014150:Antipsychotic Agents; D011942:Receptors, Adrenergic, alpha; D011954:Receptors, Dopamine; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011976:Receptors, Muscarinic