title: An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions.
abstract: An endogenous substance of the human brain, tetrahydroisoquinoline (TIQ), that had been increased in the parkinsonian brain, produced parkinsonism in marmosets after daily injection of TIQ (50 mg/kg per day, s.c. for 11 days). Tyrosine hydroxylase activity, total biopterin and dopamine concentrations were also decreased in TIQ-treated marmosets. The results suggest that TIQ is one of the candidates of neurotoxins to produce parkinsonism.
mesh_terms: D000818:Animals; D001708:Biopterins / Q000378:metabolism*; D002143:Callitrichinae / Q000502:physiology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism*; D044005:Tetrahydroisoquinolines; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
chemical_list: D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D001708:Biopterins; C014843:1,2,3,4-tetrahydroisoquinoline; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine