Effect of a somatostatin analogue, SMS 201-995, on 133Xe clearance from colonic mucosa in unanesthetized man.
The effect of intravenous bolus injection of the somatostatin analogue SMS 201-995 on mucosal and submucosal blood flow was studied with the local 133Xe clearance technique in eight subjects. Mucosal and submucosal blood flow decreased by 33% after injection of SMS 201-995. These observations suggest that SMS 201-995, like somatostatin, inhibits splanchnic blood flow.
D000368:Aged; D003106:Colon / Q000098:blood supply*; D003125:Colostomy; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007413:Intestinal Mucosa / Q000098:blood supply* / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D015282:Octreotide; D012039:Regional Blood Flow / Q000187:drug effects; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D013004:Somatostatin; D015282:Octreotide