Effects of zinc sulphate on gastric mucosal blood flow and gastric emptying of the rat.
Zinc sulphate (50 mg kg-1 p.o.) did not modify basal gastric mucosal blood flow, as measured by [3H]aniline clearance, but inhibited its reduction by noradrenaline (3.5 micrograms kg-1 min-1). Zinc sulphate also influenced gastric emptying of phenol red but its effects depended upon the dose; 30 mg kg-1 caused no variation whereas 80 mg kg-1 induced a significant delay. The nature of both actions is discussed and their implications in the development and prevention of gastric ulceration have been analysed.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005746:Gastric Emptying / Q000187:drug effects*; D005753:Gastric Mucosa / Q000098:blood supply*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010637:Phenolsulfonphthalein; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013431:Sulfates / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology*; D019287:Zinc Sulfate
D013431:Sulfates; D019287:Zinc Sulfate; D010637:Phenolsulfonphthalein; D015032:Zinc; D009638:Norepinephrine