[HLA and multiple sclerosis].
Etiology of and pathogenetic mechanisms in multiple sclerosis are still badly known; therapy is thus uncertain and poorly active. Many recent studies have nevertheless shown a weak but clear association with HLA-DR2, as the possible role of a HTLV-related virus. Infection of genetically sensitive (DR2 positive) children would induce an auto-immune disease with a cellular and humoral reactivity against myelin antigens. A rather active and certainly harmless treatment consists in administration of immunoglobulins.
D006800:Deltaretrovirus Infections / Q000276:immunology; D004198:Disease Susceptibility; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D010641:Phenotype; D012306:Risk
D006680:HLA Antigens; D006684:HLA-DR Antigens
HLA et sclérose en plaques.