Effect of antiandrogens on the hypothalamic gamma-aminobutyric acid (GABA) and glutamate contents of the Indian palm squirrel (Funambulus pennanti, Wroughton).
Intramuscular administration of 20 mg/kg flutamide (Flut) or 50 mg/kg of cyproterone acetate (CPA) daily for a period of three weeks significantly elevated the hypothalamic GABA content. CPA is found to decrease the hypothalamic glutamate level while Flut elevated it. Both, Flut and CPA reduced the hypothalamic weight.
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D003534:Cyproterone / Q000031:analogs & derivatives / Q000494:pharmacology; D017373:Cyproterone Acetate; D005260:Female; D005485:Flutamide / Q000494:pharmacology; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D007031:Hypothalamus / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D012589:Sciuridae; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000726:Androgen Antagonists; D005971:Glutamates; D018698:Glutamic Acid; D017373:Cyproterone Acetate; D005680:gamma-Aminobutyric Acid; D005485:Flutamide; D003534:Cyproterone