Effect of some recent analgesics on labor pain and maternal and fetal blood gases and pH.
This study attempts to determine the analgesic properties of nalbuphine, pentazocine and butorphanol during labor and their potential effects on maternal and fetal blood gases and pH. Butorphanol analgesia was superior to either nalbuphine or pentazocine in relieving labor pain. The studied analgesics caused significant maternal respiratory acidosis and fetal metabolic acidosis. These acidotic changes were most marked with pentazocine, moderate with nalbuphine and minimal with butorphanol.
D000328:Adult; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D001034:Apgar Score; D002077:Butorphanol / Q000627:therapeutic use; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007743:Labor, Obstetric / Q000502:physiology*; D009266:Nalbuphine / Q000627:therapeutic use; D010100:Oxygen / Q000097:blood*; D010146:Pain / Q000188:drug therapy*; D010423:Pentazocine / Q000627:therapeutic use; D011247:Pregnancy
D000700:Analgesics; D002245:Carbon Dioxide; D009266:Nalbuphine; D002077:Butorphanol; D010423:Pentazocine; D010100:Oxygen