title: Absence of acquired tolerance to neuroleptics in schizophrenic patients.
abstract: Development of increased tolerance to neuroleptics was investigated in 38 neuroleptic-respondent schizophrenic patients. At 5- or 8-year follow-up, clinical global assessments were related to changes in neuroleptic doses. In 93% of the patients gradually increasing tolerance could be excluded.
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage*; D004361:Drug Tolerance; D005500:Follow-Up Studies; D006801:Humans; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents