Effect of egg yolk lecithin on transdermal delivery of bunazosin hydrochloride.
Transdermal delivery of bunazosin HCl and the enhancing effect of egg yolk lecithin were examined using an in-vitro hairless mouse skin preparation and rabbits for in-vivo systemic absorption. The delivery of bunazosin in-vitro was small, but it was significantly enhanced when lecithin was incorporated into the same vehicle. This enhancing effect was confirmed with other drugs in-vitro. The enhancing ability was also seen in-vivo. Very little bunazosin was delivered from a propylene glycol suspension, but levels of 100-200 ng mL-1 were achieved by the incorporation of the lechithin.
D000277:Adjuvants, Pharmaceutic; D000279:Administration, Cutaneous; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage* / Q000378:metabolism; D000818:Animals; D004530:Egg Yolk; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D010713:Phosphatidylcholines / Q000494:pharmacology*; D011799:Quinazolines / Q000008:administration & dosage* / Q000378:metabolism; D011817:Rabbits; D012869:Skin Absorption / Q000187:drug effects*
D000277:Adjuvants, Pharmaceutic; D000317:Adrenergic alpha-Antagonists; D010713:Phosphatidylcholines; D011799:Quinazolines; C018176:bunazosin