Allergic contact dermatitis from chloromethyl heterocyclic intermediates in the synthesis of a histamine antagonist.
Case reports of 3 chemists who worked in a laboratory where heterocyclic chloromethyl compounds, used as intermediates in the synthesis of a histamine antagonist, were being prepared, are here presented. The results of suitable patch tests which were applied are reported and it is concluded from the results that 3 chemical intermediates were responsible for the allergic contact dermatitis in the 3 cases.
D000328:Adult; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000139:chemically induced*; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis*; D006801:Humans; D008297:Male; D010328:Patch Tests
D006634:Histamine H1 Antagonists