A comparison of the PD35-sGaw and PD20-FEV1 in assessment of the effect of oral anti-allergic compounds on the immediate asthmatic response to inhaled allergen.
Assessment of two methods of measuring airway response to allergen challenge showed that results obtained using FEV1 correlated well with those obtained using sGaw irrespective of pre-treatment. Significantly smaller amounts of allergen were required to reduce the sGaw by 35% than to reduce the FEV1 by 20%, although both indices discriminated equally well between the effects of drugs on airway responses to challenge.
D000328:Adult; D000403:Airway Resistance; D000485:Allergens; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D005541:Forced Expiratory Volume; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007665:Ketotifen / Q000627:therapeutic use*; D008297:Male; D009930:Organic Chemicals
D000485:Allergens; D001993:Bronchodilator Agents; D006634:Histamine H1 Antagonists; D009930:Organic Chemicals; C053424:HG 37-639; D007665:Ketotifen