Excitatory P1-purinoceptors on pre- and post-ganglionic cholinergic nerve terminals in the chick oesophagus.
The mechanism of action of ATP and the purinoceptors involved have been investigated on the chick oesophagus. The susceptibility of the excitatory responses to ATP/adenosine to tetrodotoxin indicates that their action is neurally mediated. Blockade of ATP/adenosine responses by atropine suggests the involvement of endogenous acetylcholine. ATP action depends on breakdown to AMP/adenosine, since theophylline blocks ATP/adenosine responses. The inhibition of ATP responses by pentolinium implies the involvement of preganglionic fibres.
D000241:Adenosine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002645:Chickens; D004947:Esophagus / Q000294:innervation*; D005260:Female; D008297:Male; D009411:Nerve Endings / Q000187:drug effects*; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011983:Receptors, Purinergic / Q000187:drug effects*; D013779:Tetrodotoxin / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology
D011950:Receptors, Cholinergic; D011983:Receptors, Purinergic; D013779:Tetrodotoxin; D001285:Atropine; D000255:Adenosine Triphosphate; D013806:Theophylline; D000241:Adenosine