Effect of metopirone-ditartrate on thermogenesis in the guinea-pig.
1. Cortisol is the major corticosteroid in the guinea-pig plasma; cortisone is detected in minor concentrations. 2. An increase in the plasma cortisol level is observed during acute cold exposure. 3. After application of metopirone-ditartrate the standard metabolic rate is depressed significantly at thermoneutrality. 4. In metopirone-treated guinea-pigs the cold-induced increase in heat production is depressed by 47% concomitant with a marked drop in body temperature. 5. It is concluded that the formation of cortisol is essential for regulatory heat production induced by acute cold exposure in the guinea-pig.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001833:Body Temperature Regulation / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D003080:Cold Temperature; D006168:Guinea Pigs / Q000502:physiology*; D006364:Hedgehogs / Q000502:physiology; D006605:Hibernation; D006854:Hydrocortisone / Q000097:blood / Q000502:physiology; D008797:Metyrapone / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet
D001786:Blood Glucose; D006854:Hydrocortisone; D008797:Metyrapone