Autacoids and some mediators in allergic and non allergic forms.
The aim of this review is that to examine some among the most important mediators involved in the onset of autacoid-mediated allergic and non-allergic symptomatology. Autacoids, such as histamine and arachidonic acid derivatives (leukotrienes and prostaglandins), mediators derived from cell membrane, such as PAF-acether and other cell-derived mediators, such as PF4, are described. Special importance is given to the respective pharmacological actions and to the mechanisms by which these actions are performed (receptors, antagonisms, synergism) from whose complexity systemic reactions might ensue. Furthermore, a part of this study is dedicated to the complex interactions among biochemical systems of the body such as Kinins, Coagulation, Fibrinolysis and Enzymatic Activity Mediators that can interfere with these interactions and support some pathologies. Besides, a chapter is devoted to Neurogenic Inflammation and therefore to Substance P and other neuropeptides.
D000818:Animals; D001095:Arachidonic Acids / Q000502:physiology; D012898:Autacoids / Q000276:immunology*; D006632:Histamine / Q000502:physiology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D008084:Lipoxygenase / Q000378:metabolism; D008954:Models, Biological; D010972:Platelet Activating Factor / Q000502:physiology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000502:physiology
D001095:Arachidonic Acids; D012898:Autacoids; D010972:Platelet Activating Factor; D011453:Prostaglandins; D006632:Histamine; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases