Effect of nadolol, a beta-adrenoceptor blocking agent, on myocardial metabolism in the dog ischaemic heart.
The effect of nadolol at a dose of 1 mg kg-1, i.v. on the ischaemic myocardial metabolism has been examined in the dog. Ischaemia was induced by ligating the left anterior descending coronary artery for 3 min, and nadolol was injected 5 min before ligation. Ischaemia caused myocardial metabolic changes; it decreased energy charge potential and inhibited glycolytic flux through phosphofructokinase reaction. Pretreatment with nadolol lessened the decrease in energy charge potential and the inhibition of glycolytic flux being caused by ischaemia. Nadolol may have a beneficial effect on the ischaemic myocardium.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D050260:Carbohydrate Metabolism; D003327:Coronary Disease / Q000378:metabolism*; D004285:Dogs; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006600:Hexosephosphates / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009248:Nadolol / Q000494:pharmacology*; D010725:Phosphocreatine / Q000378:metabolism
D000227:Adenine Nucleotides; D006600:Hexosephosphates; D010725:Phosphocreatine; D009248:Nadolol