The effect of beta-adrenoceptor blockers on the absorption and excretion of chlorothiazide in man.
The effect of beta-adrenoceptor blockers on the absorption and elimination of the diuretic chlorothiazide was studied in healthy subjects. A week of pretreatment with either pindolol (10 mg twice daily) or propranolol (80 mg twice daily) resulted in significant reduction in 36 h mean cumulative urinary recovery of chlorothiazide in two groups of six subjects compared with a control (untreated) group. A week of pretreatment with atenolol (100 mg daily) did not significantly alter 36 h cumulative urinary excretion in another group of six subjects. None of the beta-blockers significantly changed chlorothiazide half-life. It is suggested that the non-selective (as opposed to the cardioselective) beta-blockers reduce chlorothiazide absorption by the mechanism(s) discussed.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D001262:Atenolol / Q000097:blood; D002740:Chlorothiazide / Q000378:metabolism* / Q000652:urine; D006207:Half-Life; D006801:Humans; D008297:Male; D010869:Pindolol / Q000494:pharmacology; D011433:Propranolol / Q000097:blood
D000319:Adrenergic beta-Antagonists; D001262:Atenolol; D002740:Chlorothiazide; D011433:Propranolol; D010869:Pindolol