Effects of AN-132 and quinidine, antiarrhythmic agents, on plasma digoxin concentrations in rats.
The effects of AN-132, 3-(diisopropylaminoethyl-amino)-2',6'-dimethylpropionanilide.2H 3PO4, on chloroform-induced arrhythmias and plasma digoxin concentrations have been compared with those of quinidine in rats. AN-132 (0.01-3 mg kg-1) administered orally significantly inhibited the incidence of cardiac arrhythmias in a dose-related fashion. A single dose of digoxin (1 mg kg-1) given orally for 7 consecutive days was followed, on day 8, orally by digoxin alone, or together with AN-132 (50, 100 and 200 mg kg-1) or quinidine (25 and 50 mg kg-1). The AUC0-24 and Cmax of plasma digoxin were enhanced significantly by co-administration of quinidine, but not by AN-132.
D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology; D002725:Chloroform; D004077:Digoxin / Q000097:blood* / Q000493:pharmacokinetics; D004347:Drug Interactions; D005029:Ethylenediamines / Q000494:pharmacology*; D008297:Male; D011802:Quinidine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
C053205:3-(diisopropylaminoethylamino)-2',6'-dimethylpropionanilide, diphosphoric acid; D000813:Anilides; D000889:Anti-Arrhythmia Agents; D005029:Ethylenediamines; D004077:Digoxin; D002725:Chloroform; D011802:Quinidine