Luteal phase deficiency: an inadequate endometrial response to normal hormone stimulation.
Two hundred seventy-four infertile patients and 43 women with two or more previous first-trimester abortions underwent a luteal function evaluation by basal body temperature, plasma progesterone, estradiol and prolactin determination, and endometrial biopsy (repeated in a later cycle when the first was defective). An endometrial luteal phase deficiency was detected in 37 (13.5%) of the infertility cases and in 14 (32.5%) of the patients with recurrent miscarriage. However, the endometrial defect was associated with normal hormonal levels in the great majority of patients (86.3%).
D000026:Abortion, Habitual / Q000209:etiology*; D001706:Biopsy; D001831:Body Temperature; D004717:Endometrium / Q000473:pathology / Q000503:physiopathology*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D008183:Luteal Phase; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood
D011374:Progesterone; D004958:Estradiol; D011388:Prolactin