Amino acid absorption in jejunum of rats in vivo--a kinetic comparison of distal resection effects.
Jejunal absorption of leucine and cycloleucine by sham and 50% distal resected rats in vivo was studied by measuring the passive component and the active transport. After 5 months postresection the total amino acid absorption was increased. The mass-transfer coefficients of the passive process (obtained in presence of methionine) were higher in remnant jejunum than that in control rats, whereas the active transport remained unaltered after resection. When the kinetic constants of the saturable and non-saturable components were corrected for the unstirred water layer effects, the "real KD" increased in the resected group, whilst similar values for the "real Km and Jmax" were obtained.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D003515:Cycloleucine / Q000378:metabolism; D007408:Intestinal Absorption; D007583:Jejunum / Q000033:anatomy & histology / Q000378:metabolism*; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D003515:Cycloleucine; D007930:Leucine