title: Diagnosis of acute herpes simplex encephalitis by brain perfusion single photon emission computed tomography.
abstract: Brain perfusion was studied in 14 patients with acute encephalitis by use of 123I-iodoamphetamine or 99mTc-hexamethylpropyleneamine oxime and single photon emission computed tomography (SPECT), the first examination being made 4-11 days after onset of encephalitis symptoms. All 6 patients with herpes simplex virus encephalitis (HSVE) had strongly increased accumulation of radiotracer in the affected temporal lobe; in the remaining 8 results were normal. At the time of the first SPECT conventional CT images were normal in all patients. The SPECT abnormality in HSVE gradually converted over 4-10 weeks from increased tracer accumulation to greatly subnormal accumulation. Brain perfusion SPECT may be helpful in the early diagnosis of HSVE.
mesh_terms: D000208:Acute Disease; D000328:Adult; D000662:Amphetamines; D000914:Antibodies, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D004569:Electroencephalography; D004660:Encephalitis / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006561:Herpes Simplex / Q000134:cerebrospinal fluid / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D010091:Oximes; D011877:Radionuclide Imaging; D018139:Simplexvirus / Q000276:immunology; D013667:Technetium; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe; D014055:Tomography, Emission-Computed
chemical_list: D000662:Amphetamines; D000914:Antibodies, Viral; D007457:Iodine Radioisotopes; D009942:Organometallic Compounds; D010091:Oximes; C041336:4-iodoamphetamine; D019690:Technetium Tc 99m Exametazime; D013667:Technetium