Calcium-related abnormalities in fast and slow denervated skeletal muscle in rats.
Muscle weights, Ca-ATPase activity and calcium-binding proteins were studied after denervation in rat extensor digitorum longus (EDL) and soleus (Sol) muscles. Muscle weights decreased progressively as a function of denervation time: after 28 days EDL weight diminished by 70% and Sol weight by 47%. Ca-ATPase activity and calsequestrin were quite reduced in control Sol as compared to the control EDL. Denervation caused a considerable reduction in Ca-ATPase and calsequestrin in EDL, making it resemble the control Sol.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009121:Muscle Denervation; D009132:Muscles / Q000033:anatomy & histology* / Q000378:metabolism; D009929:Organ Size; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D014638:Vanadates; D014639:Vanadium / Q000494:pharmacology
D002135:Calcium-Binding Proteins; D014639:Vanadium; D014638:Vanadates; D000252:Calcium-Transporting ATPases; D002118:Calcium