Neither morphine nor clonidine influence the non-adrenergic, non-cholinergic inhibitory response in the rat gastric fundus.
Morphine and clonidine are among the few agents reported to modulate non-adrenergic, non-cholinergic (NANC) responses in different tissues. They were therefore tested for their effect on the NANC inhibitory response in the rat gastric fundus. Neither morphine (10(-5) M), nor clonidine (10(-5) M in the presence of prazosin 10(-6) M to avoid its own relaxatory effect) modified the NANC response in the rat gastric fundus.
D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D004558:Electric Stimulation; D005260:Female; D005748:Gastric Fundus / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D066298:In Vitro Techniques; D009020:Morphine / Q000494:pharmacology*; D009126:Muscle Relaxation / Q000187:drug effects; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects*
D009020:Morphine; D003000:Clonidine