The muscarinic receptor-mediated action of acetylcholine in the gastrulating chick embryo.
Some of the muscarinic receptor-mediated effects of acetylcholine in early chick embryo cells at stages three-four by Hamburger and Hamilton were studied. Acetylcholine increased the intracellular level of cGMP about two-fold. Acetylcholine raised the intracellular level of free calcium from the basal level of 120 nM to 140 nM. Atropine, a muscarinic antagonist, blocked both the above-mentioned responses.
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002118:Calcium / Q000502:physiology; D002642:Chick Embryo; D006152:Cyclic GMP / Q000502:physiology; D005775:Gastrula / Q000502:physiology*; D009024:Morphogenesis; D011976:Receptors, Muscarinic / Q000502:physiology*
D011976:Receptors, Muscarinic; D001285:Atropine; D006152:Cyclic GMP; D000109:Acetylcholine; D002118:Calcium