Comparative hormonal profile of two newly developed obese congenic rat strains.
1. The effect of feeding diets containing either 54% sucrose or cooked corn starch for 12 weeks on levels of fasting plasma insulin, corticosterone, growth hormone and glucagon were compared in two newly developed genetically obese rat strains--the normoglycemic LA/N-cp and the diabetic SHR/N-cp. 2. In corpulent rats of either strain, levels of plasma insulin and corticosterone were greater when compared to the lean littermates. Corpulent LA/N-cp rats had lower levels of plasma glucagon and higher levels of plasma growth hormone than did lean LA/N-cp rats. 3. SHR/N-cp rats fed sucrose had greater levels of corticosterone and glucagon than did SHR/N-cp rats fed starch.
D000818:Animals; D003345:Corticosterone / Q000097:blood; D004040:Dietary Carbohydrates; D005934:Glucagon / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D007328:Insulin / Q000097:blood; D008297:Male; D009765:Obesity / Q000235:genetics* / Q000503:physiopathology; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology; D011919:Rats, Inbred Strains / Q000502:physiology*; D012016:Reference Values; D013045:Species Specificity
D004040:Dietary Carbohydrates; D006728:Hormones; D007328:Insulin; D013006:Growth Hormone; D005934:Glucagon; D003345:Corticosterone