Influence of beta adrenergic blockers and their combinations with anticholinergic drugs on epileptiform activity in rabbit hippocampus.
The influence of alpha- and beta-receptor antagonists combined with drugs which act as antagonists at muscarinic and nicotinic receptor sites on epileptic focus produced by topic penicillin application was investigated. The beta-receptor blocking agent caused a faster and more intense activity of epileptogenic focus in comparison with activity in control animals, but the number of seizures decreased relatively for 25%. N-receptor antagonists diminished the facilitating effect of the beta-receptor antagonist on focal activity. Combination of m- and beta-receptor antagonists did not influence the spike activity of the focus. Treatment with alpha-receptor antagonists enhanced spikes and number of seizures only insignificantly. The combination of alpha- and n-receptor blocking substances does not influence the development of the epileptic process. The alpha-receptor antagonist together with the m-receptor blocking drug induces a facilitation of spike activity.
D000287:Administration, Topical; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001535:Benactyzine / Q000031:analogs & derivatives / Q000494:pharmacology; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000503:physiopathology*; D006624:Hippocampus / Q000187:drug effects* / Q000648:ultrastructure; D010406:Penicillins / Q000008:administration & dosage; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D011976:Receptors, Muscarinic / Q000187:drug effects; D011978:Receptors, Nicotinic / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D010406:Penicillins; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D010643:Phenoxybenzamine; C008380:metamizil; D001535:Benactyzine; D011433:Propranolol