Skeletal muscle relaxant action of an aqueous extract of Portulaca oleracea in the rat.
The aqueous extract of Portulaca oleracea produced skeletal muscle relaxation in rats following i.p. or oral administration, as assessed by the prolongation of pull-up time. The i.p. route of administration was more effective. When compared with chlordiazepoxide (20 mg/kg, i.p.), diazepam (40 mg/kg, i.p.) and dantrolene sodium (30 mg/kg, oral), the extract (200-1000 mg/kg, i.p.) proved a more effective skeletal muscle relaxant. With 1000 mg/kg i.p., 80% lethality was seen. The LD50 in an acute toxicity test in mice was 1040 mg/kg i.p.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000633:toxicity; D001569:Benzodiazepines; D003620:Dantrolene / Q000494:pharmacology; D008519:Medicine, Traditional; D051379:Mice; D008807:Mice, Inbred BALB C; D009125:Muscle Relaxants, Central; D009549:Nigeria; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D014151:Anti-Anxiety Agents; D009125:Muscle Relaxants, Central; D010936:Plant Extracts; D001569:Benzodiazepines; D003620:Dantrolene