[Effect of the TRH analog DN-1417 on the appearance of frontal midline theta activity (Fm0)].
The distinct 0 rhythm which appears in the frontal midline area during the performance of mental tasks is called Fm0. The appearance of Fm0 shows individual differences and a close relationship to the personality traits of the subject. It is also reported that administration of diazepam or alcohol brings about an increase of Fm0 along with lowering of the anxiety level. In the present study, the TRH analog DN-1417 (80 mg) was administered to 8 healthy male students for 15 days. They were all extrovert in nature and had no great neurotic tendencies as measured by the Maudsley Personality Inventory (MPI). EEG recording, determination of the blood concentration of DN-1417, and Spielberger's State-Trait Anxiety Inventory-I (STAI-I) were carried out before, during, and after drug administration. The appearance of Fm0 showed significant increase during and just after drug administration. As to anxiety, the STAI-I score showed no significant change. There was no correlation between blood concentration and Fm0. From these results, we considered that the change of appearance of Fm0 due to drug administration was not necessarily associated with change of the anxiety level, and that DN-1417, a DA releaser, increased the appearance of Fm0.
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology*; D004569:Electroencephalography; D005625:Frontal Lobe / Q000502:physiology*; D006728:Hormones / Q000494:pharmacology*; D006801:Humans; D008297:Male; D013826:Theta Rhythm; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology
D014150:Antipsychotic Agents; D006728:Hormones; D013973:Thyrotropin-Releasing Hormone; C029762:DN 1417