Pyroglutamate aminopeptidase activity in human cerebrospinal fluid decreases with age.
The activity of pyroglutamate aminopeptidase, the major enzyme catalyzing thyrotropin-releasing hormone (TRH) metabolism in human CSF, decreased with age. This decrement is not due to age-dependent appearance of any enzyme inhibitor in CSF. The results of these studies underline the importance of using age-matched controls in assessing abnormalities of TRH metabolism in CSF during disease states.
D000328:Adult; D000368:Aged; D000375:Aging / Q000134:cerebrospinal fluid*; D000626:Aminopeptidases / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011751:Pyroglutamyl-Peptidase I / Q000134:cerebrospinal fluid*
D000626:Aminopeptidases; D011751:Pyroglutamyl-Peptidase I