[Diagnostic value of 4 biological markers: lactate dehydrogenase, phosphoglucoisomerase, carcinoembryonic antigen and gammaglutamyl transpeptidase, systematically determined in patients in a hematology-oncology department].
This article is concerned with a prospective study about the systematical, simultaneous and comparative assay of four biological markers (carcino-embryonic antigen, lactate dehydrogenase, gammaglutamyl transferase and phosphohexose isomerase). This study was conducted in a department of Hematology and oncology on 258 patients. The dosage of each marker separately does not appear to be of diagnostical interest because of a lack of sensibility and specificity. But when there is a positive statistical correlation between several makers, their simultaneous dosage may allow the diagnostic of cancer and sometimes the determination of its origin.
D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D005260:Female; D005956:Glucose-6-Phosphate Isomerase / Q000097:blood*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D007938:Leukemia / Q000097:blood; D008223:Lymphoma / Q000097:blood; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*; D011446:Prospective Studies; D005723:gamma-Glutamyltransferase / Q000097:blood*
D002272:Carcinoembryonic Antigen; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D005956:Glucose-6-Phosphate Isomerase
Intérêt diagnostique de quatre marqueurs biologiques: la lacticodéshydrogénase, la phosphogluco-isomérase, l'antigène carcino-embryonnaire et la gammaglutamyl-transpeptidase dosés systématiquement chez les malades d'un service d'hématologie-oncologie.