title: [Effect of beta-blockers on retinal function in vitro].
abstract: In an attempt to identify possible beta-adrenergic mechanisms in the cat retina the authors extended their previous studies on the effects of beta-agonists (Graefe's Arch. clin. exp. Ophthalmol. 225: 33-38, 1987) to three beta-adrenergic antagonists: propranolol, ICI 118.551, and timolol were applied in micromolar concentrations to the arterially perfused, dark-adapted cat eye. The rod ERG b-wave was generally depressed, sometimes enhanced after initial depression (propranolol), without showing any clear-cut dose-dependency. In contrast, the rod-mediated optic nerve action potential exhibited dose-dependent depression of the plateau and OFF components. All effects were reversible within 60-80 minutes. These results, in conjunction with earlier data on the effects of beta-agonists and recent biochemical and autoradiographic studies, strongly support the theory that there are beta-adrenergic synaptic mechanisms located in the inner layers of the mammalian retina.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005074:Evoked Potentials, Visual / Q000187:drug effects; D009900:Optic Nerve / Q000187:drug effects; D010477:Perfusion; D011412:Propanolamines / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012160:Retina / Q000187:drug effects*; D013999:Timolol / Q000494:pharmacology
chemical_list: D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C026777:ICI 118551; D013999:Timolol; D011433:Propranolol
vernacular_title: Wirkung von beta-Blockern auf die Netzhautfunktion in vitro.