title: Biodegradable microspheres: polyacryl starch microparticles as a delivery system for the antileishmanial drug, sodium stibogluconate.
abstract: Liver parasite burdens of Leishmania donovani in the mouse have been determined after treatment with intravenous administration of sodium stibogluconate in the free or carrier form. The carrier form, in which the drug was covalently bound to polyacryl starch microparticles, was up to 100x more effective than the free form in this murine model of visceral leishmaniasis. Empty microparticles had no effect on liver parasite burdens and the enhanced in-vivo antileishmanial activity of the carrier form of the drug was apparently due to passive drug delivery to the infected liver.
mesh_terms: D000818:Animals; D000965:Antimony / Q000032:analysis; D000967:Antimony Sodium Gluconate / Q000008:administration & dosage* / Q000494:pharmacology; D001711:Biotransformation; D006224:Cricetinae; D005079:Excipients; D005260:Female; D005942:Gluconates / Q000008:administration & dosage*; D007893:Leishmania donovani; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000469:parasitology; D008099:Liver / Q000469:parasitology; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D008863:Microspheres; D013054:Spectrophotometry, Atomic; D013213:Starch / Q000031:analogs & derivatives
chemical_list: D005079:Excipients; D005942:Gluconates; D013213:Starch; C043831:starch polyacrylate; D000965:Antimony; D000967:Antimony Sodium Gluconate