Redifferentiation and subsequent dedifferentiation of the livers of roosters resulting from acute estrogen challenges.
1. Histologic and metabolic changes take place in livers of rooster receiving challenges consisting of acute doses of estrone. 2. During initial Growth and Redifferentiation livers rapidly increase in size by division of hepatocytes within most lobules, changing from cordlike to acinar configurations. 3. No new lobules appear and degeneration of some cells within lobules takes place even as cell divisions predominate. 4. Cells within lobules assume secretory features. 5. Vitellogenins, very low density lipoproteins, calcium and alkaline phosphatase increase greatly in plasma. 6. Within 35-40 days of cessation of estrogen, livers have returned to near normal sizes and plasmas exhibit normal parameters.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001053:Apolipoproteins / Q000097:blood; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002645:Chickens; D004261:DNA Replication / Q000187:drug effects; D004970:Estrone / Q000633:toxicity*; D006965:Hyperplasia; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008297:Male; D010774:Phosvitin / Q000097:blood
D001053:Apolipoproteins; D004970:Estrone; D010774:Phosvitin; D000469:Alkaline Phosphatase