Xenobiotic metabolism in motor neuron disease.
Debrisoquine, carbocysteine, and paracetamol were selected as safe drugs to investigate the ability of the liver's microsomal system to oxidise carbon, oxidise sulphur, and conjugate sulphate in patients with motor neuron disease (MND), other hospital patients, and healthy volunteers. Subjects with poor sulphur-oxidising and sulphur-conjugating activities were heavily over-represented in the MND group.
D000082:Acetaminophen / Q000378:metabolism; D000328:Adult; D000368:Aged; D002233:Carbocysteine / Q000378:metabolism; D003647:Debrisoquin / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009046:Motor Neurons; D009468:Neuromuscular Diseases / Q000378:metabolism*; D010084:Oxidation-Reduction
D000082:Acetaminophen; D002233:Carbocysteine; D003647:Debrisoquin