The pharmacokinetics and clinical effects of a low dose of alfentanil in elderly patients.
Alfentanil is a potent short-acting opioid analgesic which depresses respiration and can cause cardiovascular depression. The elderly can show greater sensitivity to opioid drugs which may be related to pharmacokinetic differences. The pharmacokinetics and clinical effects of alfentanil were studied in 10 elderly patients aged 68-86 years who were undergoing cystoscopy or urethrotomy under general anesthesia. After induction with thiopentone, and while the patient was breathing nitrous oxide with halothane 0.5% (enflurane 1.0% was given to one patient), a dose of alfentanil 4 micrograms/kg was given 15, 20, 30, 45 and 60 minutes after the alfentanil administration, and then every 30 minutes for 6 hours. Pulse rate (PR), systolic blood pressure (SBP), and minute volume (MV, calculated from the respiratory rate and the tidal volume) were measured at 1, 3, 5, 7 and 9 minutes after the alfentanil injection. Pharmacokinetic analysis showed Vc 82 (+/- S.D. 26) ml/kg; VDSS 277 (+/- S.D. 71) ml/kg; clearance 2.01 (+/- S.D. 0.64) ml/kg/min; t1/2 beta 117 (+/- S.D. 24) min. Comparison of these results with the results of other studies supports the view that older patients eliminate alfentanil less rapidly than younger patients, with prolongation of t1/2 beta and decreased clearance. The clinical results showed a decrease in minute volume from a mean value of 5944 ml before alfentanil to 1240 ml 1 minute after alfentanil (P less than 0.001). The minute volume was still significantly lower at 3 and 5 minutes, but had returned to the pre-alfentanil value by 7 minutes.(ABSTRACT TRUNCATED AT 250 WORDS)
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D015760:Alfentanil; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000493:pharmacokinetics*; D000769:Anesthesia, Inhalation; D005260:Female; D005283:Fentanyl / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006221:Halothane; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D012119:Respiration / Q000187:drug effects
D000701:Analgesics, Opioid; D015760:Alfentanil; D005283:Fentanyl; D006221:Halothane