Role of caesarean section in prevention of mother-infant transmission of hepatitis B virus.
447 infants, born to mothers positive for hepatitis B e antigen and hepatitis B surface antigen (HBsAg), received hepatitis B immunisation. A higher rate of hepatitis B virus (HBV) infection was found at birth in infants delivered vaginally (96/385, 24.9%) than in infants delivered by caesarean section (6/62, less than 10%). At birth, serum HBV-DNA was detected in 13 of 67 infants delivered vaginally, but in none of 30 infants delivered by caesarean section. Caesarean section combined with hepatitis B immunisation is advisable in infants of mothers who are chronic HBsAg carriers with high serum HBV-DNA levels.
D002585:Cesarean Section; D004279:DNA, Viral / Q000032:analysis; D036861:Delivery, Obstetric; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000517:prevention & control* / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines; D006513:Hepatitis B e Antigens / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012307:Risk Factors; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D006513:Hepatitis B e Antigens; D007136:Immunoglobulins; D014761:Viral Hepatitis Vaccines; C045213:hepatitis B hyperimmune globulin