title: Exclusion testing for Huntington's disease in pregnancy with a closely linked DNA marker.
abstract: 55 couples where one partner was at 50% risk of Huntington's disease (HD) were investigated with a DNA probe closely linked to HD, with a view to exclusion testing in a future pregnancy. In 3 of 9 pregnancies so far, HD was excluded in the absence of recombination. In 3 the risk was raised to around 50%, and in 2 exclusion tests were uninformative. The remaining couple changed their minds about termination of the pregnancy and the test was therefore judged inappropriate.
mesh_terms: D002824:Chorionic Villi / Q000032:analysis; D004247:DNA / Q000032:analysis*; D005260:Female; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis*; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D012306:Risk
chemical_list: D005819:Genetic Markers; D004247:DNA