Non-cytocidal natural variants of human immunodeficiency virus isolated from AIDS patients with neurological disorders.
To understand the mechanism of HIV-mediated neuropathology five viral isolates were obtained from four AIDS cases with central nervous system manifestations as the primary involvement. The isolates were identified as HIVs by antigenic cross-reactivity and nucleic acid hybridizations to HIV-specific antibodies and DNA probes. The replication and cytopathic properties of these isolates were studied and compared with lymphadenopathy-associated virus (HIVLAV). All isolates had replication competence equivalent to LAV, but four isolates did not kill T4 (CD-4) cells. This isolation of non-cytocidal natural variants of HIV raises the possibility that in some AIDS cases the neurological disorders might be due to HIV variants that are non-cytocidal to T4 cells. The results also indicate that virus replication and cytotoxicity are not always concordant functions in HIV.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000382:microbiology*; D000328:Adult; D000911:Antibodies, Monoclonal; D000956:Antigens, Viral / Q000032:analysis; D002493:Central Nervous System Diseases / Q000209:etiology / Q000382:microbiology*; D003588:Cytopathogenic Effect, Viral; D004279:DNA, Viral / Q000032:analysis; D005814:Genes, Viral; D006678:HIV / Q000276:immunology / Q000302:isolation & purification*; D015488:HIV Antigens; D006801:Humans; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology; D014779:Virus Replication
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D004279:DNA, Viral; D015488:HIV Antigens