Effects of triethyltin on brain octopamines and their metabolism in the rat.
The effects of triethyltin given acutely on the cerebral level of p- and m-octopamines were studied in rats. These octopamines were reduced drastically in hypothalamus and brainstem, while noradrenaline and dopamine were only slightly decreased. No important changes were observed in the activities of tyrosine hydroxylase, dopamine beta-hydroxylase or monoamine oxidase. However, the activity of aromatic L-amino acid decarboxylase was significantly reduced. The addition of the inhibitor of dopa decarboxylase, Ro 44602, caused a total inhibition of this enzyme activity. These results are discussed in terms of the possible use of the triethyltin-induced cerebral oedema as a model for the study of some aspects of the phenolamine changes related to cerebral oedema processes.
D000818:Animals; D001142:Aromatic-L-Amino-Acid Decarboxylases / Q000378:metabolism; D001711:Biotransformation; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D001933:Brain Stem / Q000201:enzymology; D004298:Dopamine / Q000494:pharmacology; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D007031:Hypothalamus / Q000201:enzymology; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D009655:Octopamine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014220:Trialkyltin Compounds / Q000494:pharmacology*; D014267:Triethyltin Compounds / Q000494:pharmacology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D014220:Trialkyltin Compounds; D014267:Triethyltin Compounds; D009655:Octopamine; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D008995:Monoamine Oxidase; D001142:Aromatic-L-Amino-Acid Decarboxylases; D004298:Dopamine; D009638:Norepinephrine