Vagal inhibition of gastric acid secretion: evidence for cholecystokinin as the inhibitory transmitter in the mouse stomach.
In the mouse isolated stomach preparation, electrical stimulation of vagal preganglionic fibres activated cholinergic excitatory pathways and noncholinergic inhibitory pathways to the gastric glands. Both were blocked by hexamethonium suggesting that there is at least one nicotinic synapse in each. The inhibitory vagal response was blocked by dibutyryl cyclic GMP, an established cholecystokinin antagonist which abolished cholecystokinin-mediated inhibition of acid secretion. It is suggested that there are direct inhibitory vagal pathways to the gastric glands and that cholecystokinin may be the inhibitory transmitter.
D000818:Animals; D001626:Bethanechol Compounds / Q000494:pharmacology; D003994:Bucladesine / Q000494:pharmacology; D002766:Cholecystokinin / Q000502:physiology*; D004558:Electric Stimulation; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018377:Neurotransmitter Agents / Q000502:physiology*; D010418:Pentagastrin / Q000494:pharmacology; D013270:Stomach / Q000294:innervation*; D014630:Vagus Nerve / Q000502:physiology*
D001626:Bethanechol Compounds; D018377:Neurotransmitter Agents; D003994:Bucladesine; D002766:Cholecystokinin; D010418:Pentagastrin