title: Effects of hexavalent chromium on trout mitochondria.
abstract: Trout liver mitochondria were incubated in the presence of micromolar concentration of potassium dichromate (Cr(VI)) under several experimental conditions. Cr(VI) strongly inhibited both state 3 and state 4 of respiration supplemented by NAD-linked substrates; it also slightly affected the respiration of FAD-linked substrates. Evidence is provided that the respiratory inhibition induced by dichromate is partially coupled to the Cr(VI) reduction mechanism occurring in mitochondria.
mesh_terms: D000818:Animals; D002840:Chromates / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D011192:Potassium Dichromate / Q000378:metabolism / Q000494:pharmacology*; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid; D014337:Trout
chemical_list: D002840:Chromates; D005971:Glutamates; D013386:Succinates; D018698:Glutamic Acid; D019802:Succinic Acid; D011192:Potassium Dichromate