title: [Complex use of benzodiazepines, lithium salts and haloperidol in the treatment of obsessive movements and tics of different origin].
abstract: Seventy-two children and adolescents with obsessive movements and tics of residual-organic etiology were treated by combined application of benzodiazepins (diazepam, phenazepam), lithium carbonate and haloperidol. The nature of obsessive syndromes and tics is considered in the light of the theory of generator mechanisms of neuropathological syndromes. The use of the studied combination due to its synergic action on the structures of the pathological system elicited a good therapeutic response while using lower doses of each drug (half to two-thirds of the conventional age-specific dosage). Reduction in drug doses in combined therapy decreases the risk of side effects and complications. The above treatment was followed by disappearance of essential and facultative symptoms in 21 patients, considerable improvement with a marked reduction of facultative symptoms in 22 cases, clear-cut improvement in combination with decreased facultative symptomatology in 14 patients, and insignificant improvement in 6 patients.
mesh_terms: D000293:Adolescent; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001569:Benzodiazepines; D002648:Child; D002675:Child, Preschool; D003192:Compulsive Behavior / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006220:Haloperidol / Q000008:administration & dosage*; D006801:Humans; D008094:Lithium / Q000008:administration & dosage*; D016651:Lithium Carbonate; D009069:Movement Disorders / Q000188:drug therapy*; D009770:Obsessive Behavior / Q000188:drug therapy*; D012213:Rheumatic Fever / Q000150:complications; D013981:Tic Disorders / Q000188:drug therapy* / Q000209:etiology; D014069:Tonsillitis / Q000150:complications; D005879:Tourette Syndrome / Q000188:drug therapy
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D016651:Lithium Carbonate; D008094:Lithium; D006220:Haloperidol
vernacular_title: Kompleksnoe primenenie benzodiazepinov, soleĭ litiia i galoperidola pri lechenii naviazchivykh dvizheniĭ i tikoznykh giperkinezov razlichnogo proiskhozhdeniia.