title: Investigation into substrate cracking of a film-coated bilayered tablet.
abstract: Substrate cracking occurred during film coating of a bilayered tablet. The cause was traced to differences in the expansion characteristics of the two layers upon exposure to heat. Thermal mechanical analysis was used to determine the coefficients of thermal expansion of the respective layers.
mesh_terms: D006244:Hardness; D013608:Tablets, Enteric-Coated / Q000592:standards*
chemical_list: D013608:Tablets, Enteric-Coated