[Effect of somatostatin on peripheral circulation. Preliminary study].
Somatostatin is a cyclic tetradecapeptide widely distributed in the human cells; it has many physiological effects. Synthetic somatostatin, actually employed in some clinical conditions, was administered intravenously to normal and arteriopathic subjects. Rheography and plethysmography of lower limbs were performed before, during and after administration. A marked improvement of blood flow and a reduction of heart rate was observed after somatostatin infusion. Some hypotheses about the mechanism of action of somatostatin are discussed, especially the action on the sympathetic nervous system or the calcium-antagonist effect on the blood vessels.
D000328:Adult; D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000188:drug therapy*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007866:Leg / Q000098:blood supply; D008027:Light; D008875:Middle Aged; D010991:Plethysmography; D010992:Plethysmography, Impedance; D013004:Somatostatin / Q000494:pharmacology / Q000627:therapeutic use*
D013004:Somatostatin
Action de la somatostatine sur la circulation périphérique. Etude préliminaire.