Evaluation of the sorbent suspension reciprocating dialyser in the treatment of overdose of paracetamol and phenobarbitone.
Poisoning with paracetamol (acetaminophen) and phenobarbitone is a common occurrence in the United States and Europe. The removal efficiency of these drugs by a sorbent suspension reciprocating dialyser (SSRD) has been investigated. The SSRD is a parallel plate dialyser with a reciprocating blood flow and free mobile sorbent suspension composed of charcoal and zeolites. This arrangement provided a system with minimal sorbent saturation. High performance liquid chromatography was used for the quantification of the drugs in aqueous and serum fluids. The in-vitro removal efficiency of the dialyser was studied by dialysing a large volume of the drug in solution for 12 to 16 h. The removal efficiency remained relatively constant up to 10 h of dialysis. The in-vivo dialysis studies were performed using normal dogs. Large doses of the drugs were administered orally or intravenously to achieve high blood levels. The clearance values obtained from these studies were comparable with, or in excess of, the values reported in the literature for conventional dialysers. The major advantage of the SSRD is the ability of the unit to be used for prolonged dialysis and to provide a system with minimal sorbent saturation due to mixing and interchange of sorbent granules next to the membrane surface.
D000082:Acetaminophen / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D005069:Evaluation Studies as Topic; D006207:Half-Life; D010634:Phenobarbital / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D006435:Renal Dialysis / Q000295:instrumentation*
D000082:Acetaminophen; D010634:Phenobarbital