Selective activation of carcinogenic aromatic amines to bacterial mutagens in the marine mussel Mytilus galloprovincialis.
The postmitochondrial fraction of the marine mussel Mytilus galloprovincialis digestive gland activates selectively precarcinogenic aromatic amines, but not precarcinogenic benzo[a]pyrene, to Salmonella typhimurium TA 98 mutagens. This activation potential is NADPH-dependent, is not inducible by exposure to Diesel 2 oil and a polluted environment, and is inhibited by methimazole. The characteristics of this activation potential are consistent with the recent finding of the presence of FAD-containing-, and lack of cytochrome P-450 dependent-, monooxygenase activity in Mytilus edulis. The presence of such selective potential in marine invertebrate(s) may bring new insight into our understanding of the fate and the effects of carcinogens in the marine environment.
D000588:Amines / Q000378:metabolism*; D000818:Animals; D001564:Benzo(a)pyrene / Q000378:metabolism; D001711:Biotransformation; D049872:Bivalvia / Q000378:metabolism*; D002273:Carcinogens / Q000378:metabolism*; D004064:Digestive System / Q000378:metabolism; D009153:Mutagens / Q000378:metabolism*
D000588:Amines; D002273:Carcinogens; D009153:Mutagens; D001564:Benzo(a)pyrene