Effect of atropine and somatostatin on bombesin-stimulated plasma immunoreactive trypsin release in man.
This study was undertaken to determine the effect of atropine and somatostatin, two inhibitors of intraduodenal pancreatic enzyme secretion, on bombesin-stimulated release of plasma immunoreactive trypsin in 6 healthy volunteers. Infusion of 5 ng/kg.min bombesin during 30 min induced significant increases in plasma trypsin from 206 +/- 20 to 334 +/- 44 ng/ml (p less than 0.01). Atropine (15 ng/kg as i.v. bolus followed by 5 ng/kg.h) had no influence on the bombesin-stimulated increase in plasma immunoreactive trypsin (207 +/- 20 to 326 +/- 54 ng/ml). Somatostatin (125 micrograms as i.v. bolus followed by 125 micrograms/h) also failed to inhibit the plasma trypsin response to bombesin (207 +/- 18 to 663 +/- 166 ng/ml). These results point to major differences in the regulation of plasma and intraduodenal trypsin secretion.
D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D001839:Bombesin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D011863:Radioimmunoassay; D013004:Somatostatin / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014357:Trypsin / Q000097:blood / Q000378:metabolism*
D013004:Somatostatin; D001285:Atropine; D014357:Trypsin; D001839:Bombesin