Kinetic mechanism for the intestinal absorption of ofloxacin.
The absorptive behaviour of ofloxacin, a quinolone antibacterial agent, was studied following recirculation in small intestine of both male and female rats, at initial doses ranging from 0.125 to 5 mg mL-1. A saturable Michaelis-Menten process is suggested to explain the intestinal absorption. No significant differences were found in the absorption parameters per metabolic weight unit.
D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D008297:Male; D015242:Ofloxacin; D010078:Oxazines / Q000493:pharmacokinetics*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin