title: An outbreak of meningococcal disease in Gloucestershire.
abstract: Between October, 1981, and March, 1986, there were 65 cases of meningococcal infection, about five times the expected number, in Gloucester Health District. The cases, mainly in teenagers and young adults, were clustered in the Stroud district and in the southern part of Gloucester City, and most were caused by a sulphonamide-resistant group B type 15 meningococcus. 2 patients died. Only 57% of meningitis cases were formally notified. 7 (11%) patients had septicaemia without meningitis, not a notifiable disease. All meningococcal disease should be made notifiable and meningococci should be serotyped routinely so that the epidemiology of the disease can be monitored before the introduction of suitable vaccines.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003140:Communicable Disease Control; D004196:Disease Outbreaks / Q000453:epidemiology*; D004352:Drug Resistance, Microbial; D004739:England; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008589:Meningococcal Infections / Q000453:epidemiology*; D009345:Neisseria meningitidis / Q000187:drug effects / Q000302:isolation & purification; D013449:Sulfonamides / Q000494:pharmacology
chemical_list: D013449:Sulfonamides