Activity of some hydrolases in mice with transplantable lymphatic leukemia P 388.
Mice--BDF, hybrides, males aged 3 months were injected intraperitoneally with 10(4) lymphatic leukemia cells P 388. The mice were killed by bleeding after 2.5 and 10 days after the injection. Gamma-glutamyltransferase (GGT), leucylaminopeptidase (LAP) and cobalt activated acylase activity were determined in the serum of the mice. The inner organs of the animals were verified histopathologically. A statistically significant increase in the activity of the examined enzymes was observed together with the development of transplantable leukemia. These enzymes can be helpful in early monitoring of lymphatic leukemia P 388 in mice--as markers of cancer growth.
D000581:Amidohydrolases / Q000097:blood*; D000818:Animals; D004796:Clinical Enzyme Tests; D003035:Cobalt / Q000494:pharmacology*; D007931:Leucyl Aminopeptidase / Q000097:blood*; D007941:Leukemia P388 / Q000175:diagnosis / Q000201:enzymology* / Q000473:pathology; D007942:Leukemia, Experimental / Q000201:enzymology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D005723:gamma-Glutamyltransferase / Q000097:blood*
D003035:Cobalt; D005723:gamma-Glutamyltransferase; D007931:Leucyl Aminopeptidase; D000581:Amidohydrolases; C019665:amidase