[Development and significance of estrogen-induced increase in the activity of several liver enzymes].
In experiments on adult, female rats, the author confirm the stimulatory effect of 50 micrograms kg-1 17-beta-estradiol daily, s.c., for more than 1 week on the activity of liver tyrosine aminotransferase and tryptophan pyrrolase and describe experiments suggesting an increased glucocorticoid sensitivity, as a consequence of the estrogen treatment. The study contributes to the information on potential side effects of hormonal contraception.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000201:enzymology*; D051381:Rats; D014366:Tryptophan Oxygenase / Q000378:metabolism*; D014444:Tyrosine Transaminase / Q000378:metabolism*
D004958:Estradiol; D003907:Dexamethasone; D014366:Tryptophan Oxygenase; D014444:Tyrosine Transaminase
Vorkommen und Bedeutung östrogenbedingter Aktivitätssteigerung einiger Leberenzyme.