title: CD2 is involved in regulating cyclic AMP levels in T cells.
abstract: The human T lymphocyte-specific CD2 (T11) molecule, that regulates T cell activation, is capable of mediating increases of intracellular cAMP. Monoclonal antibodies directed to different epitopes of the CD2 molecule which either induce or inhibit T cell proliferation are capable of triggering an increase of cAMP comparable to that induced by reagents which activate adenylate cyclase. These results indicate that there is a relationship between the CD2 membrane molecule and the adenylate cyclase system.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000911:Antibodies, Monoclonal / Q000502:physiology; D000943:Antigens, Differentiation / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D018801:CD2 Antigens; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D007166:Immunosuppressive Agents / Q000502:physiology; D008213:Lymphocyte Activation; D011971:Receptors, Immunologic / Q000276:immunology*; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D000954:Antigens, Surface; D018801:CD2 Antigens; D007166:Immunosuppressive Agents; D011971:Receptors, Immunologic; D000242:Cyclic AMP; D000262:Adenylyl Cyclases