title: Chromosomal location of human P-glycoprotein gene sequences.
abstract: Nonresponse to chemotherapy may result from the acquisition of multidrug resistance by malignant cells. Overexpression of the 170,000 dalton cell surface P-glycoprotein is associated with this phenotype and this appears to result from amplification of a multigene family coding for this protein. A cDNA encoding a conserved portion of P-glycoprotein has been cloned from hamster cells, and this was used in the present study to localize human P-glycoprotein gene sequences to chromosome 7q36.
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000818:Animals; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D003001:Cloning, Molecular; D006224:Cricetinae; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D007621:Karyotyping; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D009693:Nucleic Acid Hybridization
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D006023:Glycoproteins; D008565:Membrane Proteins; D004247:DNA; D004262:DNA Restriction Enzymes