HLA haplotype A1 B8 DR3 as a risk factor for HIV-related disease.
Of 32 patients exposed to a single batch of factor VIII contaminated with human immunodeficiency virus (HIV), 18 became antibody positive. Serial T cell subset analyses over the succeeding four years have shown a progressive decline in circulating T4 cells in those 18 but no change in the 14 who remain seronegative. 2 of the seroconverters have died and a further 7 have symptoms attributable to HIV infection. In the group as a whole, the HLA haplotype A1 B8 DR3 was weakly associated with an increased risk of seroconversion on exposure to the virus while, in those who seroconverted, it was strongly associated with a rapid decline in T4 cells and development of HIV-related symptoms within four years of infection.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D004340:Drug Contamination; D005169:Factor VIII / Q000627:therapeutic use; D005500:Follow-Up Studies; D006678:HIV / Q000235:genetics* / Q000276:immunology; D015483:HIV Antibodies; D006679:HIV Seropositivity / Q000150:complications / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics*; D015788:HLA-A1 Antigen; D015795:HLA-B8 Antigen; D006681:HLA-D Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D015803:HLA-DR3 Antigen; D006239:Haplotypes; D006467:Hemophilia A / Q000276:immunology / Q000628:therapy; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology
D000914:Antibodies, Viral; D015483:HIV Antibodies; D006680:HLA Antigens; D015788:HLA-A1 Antigen; D015795:HLA-B8 Antigen; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D005169:Factor VIII