The binding of the benzimidazole dye H8208 to DNA and to polyinosinic-polycytidylic acid.
The benzimidazole dye H8208 (2-(4-aminophenyl)-5-(4-methylpiperazin-1-yl) benzimidazole) has been shown to intercalate into calf thymus DNA and into polyinosinic-polycytidylic acid (a model for A conformation DNA) by a variety of spectroscopic techniques. The binding affinity of the dye was found to be similar to both nucleic acids.
D000814:Aniline Compounds / Q000378:metabolism*; D000818:Animals; D001562:Benzimidazoles; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D005454:Fluorescence Polarization; D006358:Hot Temperature; D011070:Poly I-C / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet
D000814:Aniline Compounds; D001562:Benzimidazoles; C023989:H8208; D004247:DNA; D011070:Poly I-C