title: [Metabolic characteristics of brain proteins and neuromediators in the late postresuscitation period].
abstract: Interferometric and cytophotometric examination of the neurons of the motor area of the cerebral cortex and caudate nucleus in dogs in the late postresuscitation period has revealed a significant decrease in protein concentrations and activity of acetylcholinesterase (ACE), an increase in the activity of acetylcholinesterase (ACE), an increase in the activity of monoamine oxidase (MAO) and size of the cells of layers III and V of the motor cortex and caudate nucleus type I Golgi's neurons 12 days after clinical death. One month after resuscitation the protein concentrations were considerably higher than the normal values, levels of ACE normalized, levels of MAO in layer III of the motor cortex normalized but rose drastically in layer V and in the caudate nucleus. Neurons in type I Golgi's cells and in layer III of the motor cortex diminished in size. On the basis of their own and literature date the authors conclude that the motor cortex neurons are more sensitive to conditions of the terminal status than the caudate nucleus neurons and that protein metabolism and that of neuromediators interact in the process of restoration of the patient's neurological status.
mesh_terms: D000110:Acetylcholinesterase / Q000032:analysis / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D003592:Cytophotometry; D004285:Dogs; D006651:Histocytochemistry; D007368:Interferometry; D008027:Light; D008995:Monoamine Oxidase / Q000032:analysis / Q000378:metabolism; D009044:Motor Cortex / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000032:analysis / Q000378:metabolism*; D012151:Resuscitation; D013997:Time Factors
chemical_list: D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D008995:Monoamine Oxidase; D000110:Acetylcholinesterase
vernacular_title: Ob osobennostiakh obmena belkov i nekotorykh neĭromediatorov mozga v pozdnem postreanimatsionnom periode.