Thyrotropin releasing hormone (TRH) modified excitability of spinal cord dorsal horn cells.
Thyrotropin releasing hormone (TRH) has been identified recently in fibers and cell bodies in the dorsal horn of the spinal cord, but its function in the dorsal horn is not known. The present study investigated the effects of TRH applied by iontophoresis on the excitability of dorsal horn cells that were responsive to mechanical stimulation of the ipsilateral hindlimb. TRH facilitated glutamate-induced firing of these cells without directly driving the cells in the absence of glutamate. These results suggest that TRH may modulate transmission of somatosensory information in the spinal cord.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D006614:Hindlimb / Q000294:innervation; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D010812:Physical Stimulation; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D005971:Glutamates; D012701:Serotonin; D018698:Glutamic Acid; D013973:Thyrotropin-Releasing Hormone