title: Endemic goitre in central China caused by excessive iodine intake.
abstract: Thyroid status was examined in children from two villages in central China where the iodine concentrations in drinking water were 462.5 and 54 micrograms/l. Goitres were present in 65% (n = 120) and 15.4% (n = 51), respectively. All children in both groups were clinically euthyroid and neurologically normal. Growth measurements and intellectual performance were similar in the two groups. Children from the high-iodine village had a lower mean serum triiodothyronine and higher serum free thyroxine and serum thyroid-stimulating hormone concentrations than the children from the control village. 2 cases of overt hypothyroidism were detected in the high-iodine village.
mesh_terms: D000293:Adolescent; D002648:Child; D002681:China; D006043:Goiter, Endemic / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D007037:Hypothyroidism / Q000453:epidemiology; D007455:Iodine / Q000506:poisoning*; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000097:blood; D014873:Water Pollutants / Q000506:poisoning*; D014874:Water Pollutants, Chemical / Q000506:poisoning*; D014881:Water Supply / Q000032:analysis
chemical_list: D013963:Thyroid Hormones; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D007455:Iodine