[Effect of commercial beta blockers and their combination with artificial tears on the duration of tear film stability].
The influences of 8 different beta-blockers on the tear film stability-measured on the breakup time (BUT) of normal and healthy volunteers-was compared. All beta-blockers led to BUT reduction, however, the lowest influence was observed with levobunolol. The duration of this effect was compared with that of levobunolol, timolol and metipranolol. While the minor BUT alterations induced by levobunolol recovered after 30 min and were completely restored after 1 h, those of the two other beta-blockers lasted for over 2 h. The combination of timolol 0.5% with different artificial tears containing mainly polyvinyl alcohol (PVA) 1.4%, methylcellulose and polyacrylic acid initially led also to BUT reduction. The best results were obtained with PVA 1.4%.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D004338:Drug Combinations; D004355:Drug Stability; D006801:Humans; D002040:Levobunolol / Q000494:pharmacology; D014290:Metipranolol / Q000494:pharmacology; D011142:Polyvinyl Alcohol / Q000494:pharmacology; D013666:Tears / Q000187:drug effects*; D013997:Time Factors; D013999:Timolol / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D004338:Drug Combinations; D013999:Timolol; D011142:Polyvinyl Alcohol; D002040:Levobunolol; D014290:Metipranolol
Intensität und Dauer der Tränenfilmaufrisszeitänderungen durch handelsübliche Betablocker und ihre Kombination mit Tränenfilmersatzmitteln.