X-linked immunodeficiency with hyperimmunoglobulinemia M appears to be linked to the DXS42 restriction fragment length polymorphism locus.
The gene involved in X-linked immunodeficiency with hyperimmunoglobulinemia M (XHM) was localized by the use of nine restriction fragment length polymorphic (RFLP) markers covering the entire X chromosome. Multipoint linkage analysis of RFLP data obtained in a three generation XHM pedigree indicates the Xq24-q27 area around the DXS42 RFLP locus as the most likely localization of the XHM locus.
D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006942:Hypergammaglobulinemia / Q000235:genetics*; D007075:Immunoglobulin M; D007153:Immunologic Deficiency Syndromes / Q000235:genetics*; D008126:Lod Score; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D014960:X Chromosome
D005819:Genetic Markers; D007075:Immunoglobulin M