Inhibition of metabolic cooperation by the anticonvulsants, diphenylhydantoin and phenobarbital.
High densities of 6-thioguanine-sensitive Chinese hamster V79 cells reduce the recovery of co-cultured 6-thioguanine-resistant cells through a form of intercellular communication (metabolic cooperation). Diphenylhydantoin and phenobarbital, suspected human and animal teratogens and tumor promoters, were able to inhibit intercellular communication at noncytotoxic doses. A potentiation was observed when a mixture of the two chemicals was used.
D000818:Animals; D002450:Cell Communication / Q000187:drug effects*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D004347:Drug Interactions; D004351:Drug Resistance; D008168:Lung; D010634:Phenobarbital / Q000633:toxicity*; D010672:Phenytoin / Q000633:toxicity*; D013866:Thioguanine / Q000633:toxicity
D010672:Phenytoin; D013866:Thioguanine; D010634:Phenobarbital