Evaluation of N-isopropyl-[125I]p-iodoamphetamine affinity sites in rat brain by autoradiography.
Affinity sites of N-isopropyl-[125I]p-iodoamphetamine (IMP) were studied in rat brain employing in vitro technique of receptor autoradiography. High degrees of IMP accumulation were observed in almost regions of white matter and some of gray matter. Phenethylamine, glutamic acid and serotonin suppressed IMP accumulation in all brain regions, in cerebral cortex and in hypothalamus, respectively. These results indicated that IMP was accumulated mainly due to its physicochemical property of lipophilicity and might have some interactions with neurotransmitter receptors.
D000662:Amphetamines / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001665:Binding Sites; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004347:Drug Interactions; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D010627:Phenethylamines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology; D014018:Tissue Distribution
D000662:Amphetamines; D005971:Glutamates; D007457:Iodine Radioisotopes; D010627:Phenethylamines; C029261:phenethylamine; D012701:Serotonin; D018698:Glutamic Acid; D020367:Iofetamine