In vitro study on corneal permeability to bunazosin.
Corneal permeability of bunazosin, one of the alpha-adrenergic receptor antagonists, was investigated in vitro using excised rabbit cornea mounted on a corneal permeability apparatus, and the enhancing effects of various acids on the permeability of bunazosin were evaluated. Caprylic and capric acid elevated octanol/water partition coefficient of bunazosin, and corneal permeability was increased, probably as a result of ion-pair formation between them. Neither bunazosin, these acids, or the ion-pair caused corneal swelling. These acids, in contrast, had little effect on the partition of pilocarpine, or on corneal permeability.
D000317:Adrenergic alpha-Antagonists / Q000378:metabolism*; D000818:Animals; D002210:Caprylates / Q000494:pharmacology; D003315:Cornea / Q000032:analysis / Q000378:metabolism*; D003652:Decanoic Acids / Q000494:pharmacology; D066298:In Vitro Techniques; D000442:Octanols / Q000032:analysis; D010539:Permeability; D011799:Quinazolines / Q000378:metabolism*; D011817:Rabbits; D014867:Water / Q000032:analysis
D000317:Adrenergic alpha-Antagonists; D002210:Caprylates; D003652:Decanoic Acids; D000442:Octanols; D011799:Quinazolines; D014867:Water; C018176:bunazosin; C031492:octanoic acid