Effect of ethanol on cardiac beta-adrenoceptors.
Liquid diets are commonly used as vehicles for chronic administration of ethanol to rodents. After mice had consumed an ethanol-free liquid diet for either seven or eight days, the number of cardiac beta-adrenoceptors and the maximum response of adenylate cyclase to isoproterenol were decreased. This change was associated with a decrease in the number of high-affinity agonist binding sites. When mice were fed ethanol in the liquid diet, there was a further decrease in the number of cardiac low-affinity agonist (isoproterenol) binding sites, but no further change in the biochemical response to isoproterenol. The data suggest that stress and/or nutritional factors can alter the number, the coupling and the function of cardiac beta-adrenoceptors and that chronic ethanol ingestion enhances certain aspects of these changes.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000318:Adrenergic beta-Agonists / Q000378:metabolism / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D004032:Diet; D000431:Ethanol / Q000494:pharmacology*; D007457:Iodine Radioisotopes; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism*
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D007457:Iodine Radioisotopes; D011943:Receptors, Adrenergic, beta; D000431:Ethanol; D000262:Adenylyl Cyclases; D007545:Isoproterenol