Lack of dose-rate effect for mutation induction by gamma-rays in human TK6 cells.
Survival and mutation induction in a human lymphoblastoid cell line ('TK6'), after acute X- and low dose rate continuous gamma-irradiation, were investigated using the hypoxanthine guanine phosphoribosyl transferase (HGPRT)- and the thymidine kinase (TK)-mutation assay. The surviving fraction after acute exposure decreased exponentially (D0 = 0.47 Gy). The HGPRT- and TK-mutation frequencies after acute X- and continuous gamma-irradiation (2.7 and 27 mGy/h) showed linear responses and no dose-rate dependence.
D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D066298:In Vitro Techniques; D009154:Mutation
D003037:Cobalt Radioisotopes