title: Heterogeneity in the map distance between X-linked agammaglobulinemia and a map of nine RFLP loci.
abstract: In nine family pedigrees in which X-linked agammaglobulinemia (XLA) is segregating, a multi-point linkage analysis has been carried out. In each family, the map distance, d, between XLA and a fixed point in a known map of nine RFLP loci on the X chromosome was estimated by calculating the log likelihoods, L(d). Using a new method, the 10-point likelihood was approximated by appropriately combining three 4-point likelihoods. Homogeneity tests (admixture tests) were performed showing clear evidence for heterogeneity of XLA.
mesh_terms: D000361:Agammaglobulinemia / Q000235:genetics*; D002874:Chromosome Mapping; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D010375:Pedigree; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D014960:X Chromosome
chemical_list: D005819:Genetic Markers