Somatostatin antiserum blocks carbachol-induced increase of paradoxical sleep in the rat.
Injection of carbachol into the nucleus tractus solitarius (NTS) produced an increase of paradoxical sleep (PS). When somatostatin antiserum (SRIF-AS) was infused continuously following carbachol injection, the increase in PS was blocked. These results suggest that carbachol-induced increase in PS is mediated by somatostatin. In addition, they confirm the role of somatostatin in the generation of PS.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D007106:Immune Sera; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012895:Sleep, REM / Q000187:drug effects / Q000502:physiology*; D013004:Somatostatin / Q000276:immunology / Q000502:physiology*
D007106:Immune Sera; D013004:Somatostatin; D002217:Carbachol