Treatment of solar urticaria with terfenadine.
Treatment with the H1 receptor antagonist terfenadine increased significantly the dose of radiation required for weal and flare formation in 5 patients with idiopathic solar urticaria. The dose of radiation required to produce immediate erythema localised to the irradiation site was unchanged by terfenadine. The weal and flare reaction in solar urticaria, but not the immediate erythema, is mediated by histamine acting on the H1 receptor.
D000328:Adult; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D004890:Erythema / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D013472:Sunlight / Q000009:adverse effects*; D016593:Terfenadine; D014466:Ultraviolet Rays; D014581:Urticaria / Q000188:drug therapy* / Q000209:etiology
D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D016593:Terfenadine