Lipid profile improvement following celiprolol.
Many beta-blockers adversely affect serum lipid levels. We have, therefore, monitored blood pressure and serum lipids in 22 patients (mean age: 42.5 years) with essential hypertension (WHO stages I-II) who were treated with celiprolol for 4 weeks, and in 12 patients (mean age: 39.8 years) with essential hypertension (WHO stages I-II) who received celiprolol for 12 months. Standing blood pressure was significantly reduced after 4 weeks and 12 months of treatment, and there were slight decreases in serum cholesterol. In addition, serum triglyceride levels decreased significantly after 4 weeks, and there was a smaller decrease in the patients treated for 12 months. The pathologically elevated pre-treatment lipid values were, therefore, reduced to levels within the normal range. Analysis by lipid electrophoresis showed an increase in the high density lipoprotein (HDL) fraction and a decrease in both the low density lipoprotein (LDL) fraction and the LDL/HDL ratio. During the long-term study there was also a significant reduction in serum fibrinogen. Our results show that celiprolol does not adversely alter serum lipids, and it may even have a beneficial effect on these variables.
Herrmann
J M
JM
Department of Psychosomatic Medicine, University of Ulm, FRG.
von Heyman
F
F
Freischütz
G
G
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D017272:Celiprolol; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
D000319:Adrenergic beta-Antagonists; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D011412:Propanolamines; D014280:Triglycerides; D002784:Cholesterol; D017272:Celiprolol