Differences in "host infiltrates" among lymphoma patients treated with anti-idiotype antibodies: correlation with treatment response.
To correlate treatment responses with numbers and types of "host cell infiltrates," lymphoid tissues from 10 patients with low-grade B cell malignancies were stained before, during, and after anti-idiotype therapy with a panel of monoclonal antibodies applied to frozen sections. Tissue penetration by the anti-idiotype antibodies was confirmed in five patients by these immunoperoxidase methods. Large numbers of phenotypic T helper cells were the main component of the "host infiltrate" in most patients. Two patients showed a complete and a near-complete clinical remission, four others had partial responses, and four did not respond to therapy. The two patients that developed clinical remission demonstrated the largest number of T cells, T helper cells, TAC+ cells, Leu-7+ cells, and in general the smallest number of proliferating cells as measured by the Ki-67 antibody. Other major differences in host cells were not evident among the patients. These preliminary data suggest that the type and amount of "host infiltrate" in low-grade B cell lymphomas may predict which patients will respond to anti-idiotype therapy.
Garcia
C F
CF
Lowder
J
J
Meeker
T C
TC
Bindl
J
J
Levy
R
R
Warnke
R A
RA
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000276:immunology; D002465:Cell Movement; D006651:Histocytochemistry; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000032:analysis / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D051379:Mice; D011971:Receptors, Immunologic / Q000032:analysis; D015375:Receptors, Interleukin-2; D013602:T-Lymphocytes, Cytotoxic / Q000473:pathology / Q000502:physiology; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000473:pathology / Q000502:physiology; D014018:Tissue Distribution
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D007130:Immunoglobulin Idiotypes; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2