title: Effect of nicotine on in vitro human sperm penetrability through cervical mucus and motility parameters.
abstract: Nicotine at concentrations found in the cervical mucus of female smokers appeared to enhance in vitro human sperm penetrability through ovulatory bovine cervical mucus. Sperm motility parameters were not affected by the addition of nicotine to semen samples incubated with BWW medium. Overall, these results suggest that a direct inhibitory effect of nicotine on sperm penetrability through cervical mucus is not responsible for the apparent increase in cervical factor infertility present in smoking women.
authors.affiliation: Department of Obstetrics and Gynecology, University of Minnesota, Minneapolis.
authors.forename: L A
authors.initials: LA
authors.lastname: Crandall
authors.forename: H C
authors.initials: HC
authors.lastname: Hensleigh
authors.forename: W R
authors.initials: WR
authors.lastname: Phipps
mesh_terms: D002582:Cervix Mucus / Q000502:physiology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects*; D013084:Sperm-Ovum Interactions / Q000187:drug effects*
chemical_list: D009538:Nicotine