The generation of acetonemia/acetonuria following ingestion of a subtoxic dose of isopropyl alcohol.
A subtoxic dose of isopropyl alcohol was ingested by three subjects to evaluate the time to and extent of acetone generation and to explore its detection in the urine. Maximal serum isopropyl alcohol concentrations were observed by 30 minutes after ingestion of approximately 1 oz 70% isopropyl alcohol (0.4 mL/kg), but maximal serum acetone concentrations were not recorded until at least four hours postingestion. Urine tested positive (small) for acetone within three hours of ingestion using Acetest urine testing tablets (Ames Labs, Elkhart, IN). It was concluded that acetonemia occurs early after ingestion of isopropyl alcohol and increases as serum isopropyl alcohol concentrations decline. In addition, acetonuria may be qualitatively measured by three hours postingestion with rapid urine screening tests and may remain positive for 24 hours.
Lacouture
P G
PG
Division of Clinical Pharmacology and Toxicology, Children's Hospital, Boston, MA 02115.
Heldreth
D D
DD
Shannon
M
M
Lovejoy
F H
FH
D000433:1-Propanol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D000096:Acetone / Q000097:blood* / Q000652:urine*; D000284:Administration, Oral; D000328:Adult; D006801:Humans; D008297:Male; D010865:Pilot Projects
D000096:Acetone; D000433:1-Propanol