Absence of cinoxacin-induced DNA fragmentation and mutations in the rat granuloma pouch.
The mutagenic and DNA-damaging activities of cinoxacin were evaluated in the rat granuloma pouch assay (GPA) in order to assess its genotoxic potential in vivo. High doses of this antimicrobial quinolone, either directly injected into the pouch or administered by gavage, did not induce mutation at the hgprt locus or DNA fragmentation in granuloma cells. Moreover, DNA damage was absent in the liver and kidney of rats given cinoxacin by the oral route.
Pino
A
A
Istituto di Farmacologia dell'Università, Genova, Italy.
Maura
A
A
Grillo
P
P
D000818:Animals; D002937:Cinoxacin / Q000494:pharmacology / Q000633:toxicity*; D004247:DNA / Q000187:drug effects*; D004249:DNA Damage; D005260:Female; D006099:Granuloma; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009152:Mutagenicity Tests; D009154:Mutation; D011724:Pyridazines / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D011724:Pyridazines; D004247:DNA; D002937:Cinoxacin