title: The influence of atenolol and prazosin on serum lipids and atherosclerosis in minipigs fed a hyperlipidemic diet.
abstract: 1. The effect of the adrenergic blockers prazosin and atenolol were tested in hypercholesterolemic Göttingen minipigs. 2. After 1 yr there was a significant reduction of plasma triglycerides and total cholesterol in the medicated animals as compared to untreated ones. 3. No significant difference in atherosclerotic lesions was observed.
authors.affiliation: Department of Pharmacology and Toxicology, Norwegian College of Veterinary Medicine.
authors.forename: I
authors.initials: I
authors.lastname: Nafstad
authors.forename: S
authors.initials: S
authors.lastname: Tollersrud
authors.forename: K
authors.initials: K
authors.lastname: Eriksen
authors.forename: A
authors.initials: A
authors.lastname: Helgeland
authors.forename: L A
authors.initials: LA
authors.lastname: Solberg
authors.forename: J
authors.initials: J
authors.lastname: Bredesen
authors.forename: O
authors.initials: O
authors.lastname: Dale
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000097:blood* / Q000473:pathology; D001262:Atenolol / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004032:Diet; D005260:Female; D005978:Glutathione / Q000097:blood; D006949:Hyperlipidemias / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000473:pathology; D008297:Male; D011224:Prazosin / Q000494:pharmacology*; D013552:Swine; D013556:Swine, Miniature; D014810:Vitamin E / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D002791:Cholesterol, Dietary; D008055:Lipids; D014810:Vitamin E; D001262:Atenolol; D005723:gamma-Glutamyltransferase; D005978:Glutathione; D011224:Prazosin