The biochemical and pathological changes produced by the intratracheal instillation of certain components of zinc-hexachloroethane smoke.
Zinc chloride which is formed by igniting a mixture of zinc oxide and hexachloroethane in the production of white smokes has been shown to produce oedema when given to rats as a single instillation. The oedematous reaction, as assessed by histopathology and measurements of alveolar surface protein in lavage fluid, is variable, dose-dependent, and maximal at 3 days but at sub-lethal doses it regresses after 7 days. The parent compound, zinc oxide, does not produce these effects. In some animals there is evidence of a fibrogenic response at 7 days post-exposure although it is currently unknown whether or not this effect is progressive.
Richards
R J
RJ
Department of Biochemistry, University College, Cardiff, Wales.
Atkins
J
J
Marrs
T C
TC
Brown
R F
RF
Masek
L
L
D000818:Animals; D002712:Chlorides / Q000633:toxicity*; D004347:Drug Interactions; D004980:Ethane / Q000031:analogs & derivatives*; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D007322:Instillation, Drug; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011654:Pulmonary Edema / Q000139:chemically induced*; D051381:Rats; D012906:Smoke; D014132:Trachea; D015032:Zinc / Q000633:toxicity*; D017967:Zinc Compounds; D015034:Zinc Oxide / Q000633:toxicity*
D002712:Chlorides; D006843:Hydrocarbons, Chlorinated; D012906:Smoke; D017967:Zinc Compounds; C016837:zinc chloride; C010182:hexachloroethane; D015032:Zinc; D004980:Ethane; D015034:Zinc Oxide