Dual effect of activin A on cell growth in Balb/c 3T3 cells.
Effects of activin A on cell growth were studied in Balb/c 3T3 cells. When incubated with serum, activin A inhibited serum-induced increase in DNA synthesis in a concentration-dependent manner. Activin A also inhibited serum-induced increase in cell number. When added in quiescent cells, activin A did not affect competence-inducing activity of PDGF. Activin A by itself had a small competence-inducing activity. In contrast, when added in competent cells, activin A inhibited progression activity of platelet-poor plasma. These results indicate that activin A has dual action on cell proliferation in Balb/c 3T3 cells.
Kojima
I
I
Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.
Ogata
E
E
D028341:Activins; D000818:Animals; D001792:Blood Platelets / Q000502:physiology; D002417:Cattle; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D003470:Culture Media; D004261:DNA Replication / Q000187:drug effects*; D007265:Inhibins / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism
D003470:Culture Media; D010982:Platelet-Derived Growth Factor; D028341:Activins; D007265:Inhibins; D013936:Thymidine