title: The mechanism of acute gastric ulcer after induced hemorrhagic shock.
abstract: Changes in gastric mucosal blood flow were investigated for their relationship to gastric mucosal prostaglandin E2 (PGE2) and noradrenaline (NA) in rats with hemorrhagic shock. The results were as follows: 1) Gastric mucosal blood flow and NA decreased after hemorrhage. Gastric mucosal PGE2 initially increased after exsanguination and then markedly decreased. 2) Administration of NA before hemorrhage resulted in an increase of PGE2. However, the PGE2 value for animals receiving NA after hemorrhage was not different from that of non-NA-treated group. 3) Pre-treatment with PGE2 suppressed the reduction in both gastric mucosal blood flow and NA and the development of ulcer. These results suggest that the increase in gastric mucosal PGE2 in the early stage of shock might represent a phenomenon of adaptation by the adrenergic activation, and the decrease in PGE2 in the late stage might result from impaired synthesis of PGE2 due to persistent hypoxia and might be one of the possible factors in ulcer formation.
authors.affiliation: First Dept. of Surgery, Kobe University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Urakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nagahata
authors.forename: Y
authors.initials: Y
authors.lastname: Azumi
authors.forename: A
authors.initials: A
authors.lastname: Itoh
authors.forename: I
authors.initials: I
authors.lastname: Sano
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.forename: Y
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Ichihara
authors.forename: H
authors.initials: H
authors.lastname: Moritomo
authors.forename: Y
authors.initials: Y
authors.lastname: Saitoh
mesh_terms: D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure; D015232:Dinoprostone / Q000378:metabolism*; D005753:Gastric Mucosa / Q000098:blood supply / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D013276:Stomach Ulcer / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology
chemical_list: D015232:Dinoprostone; D009638:Norepinephrine; D007213:Indomethacin