Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil.
1. Modafinil, a putative central alpha 1 adrenergic agonist, was tested in idiopathic hypersomnia and narcolepsy. 2. Sleep attacks and drowsiness were significantly decreased in 83% of 18 hypersomniac subjects and 71% of 24 narcoleptics. 3. When cataplectic episodes were not totally suppressed the association of a low dose of Clomipramine was successful in improving them. 4. Modafinil, used for at least 3 years in some patients, produces, in most cases, no peripheric sides effects, does not disturb night sleep and is never responsible of tolerance of drug dependence.
Bastuji
H
H
Lab. Neurophysiologie Clinique, Hôpital Neurologique, Lyon, France.
Jouvet
M
M
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000328:Adult; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D006970:Disorders of Excessive Somnolence / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077408:Modafinil; D009290:Narcolepsy / Q000188:drug therapy*; D012890:Sleep / Q000187:drug effects; D012893:Sleep Wake Disorders / Q000188:drug therapy*
D000316:Adrenergic alpha-Agonists; D001559:Benzhydryl Compounds; D000077408:Modafinil