Dibromochloropropane (DBCP) effects on the reproductive function of the adult male rat.
In order to evaluate the effect of dipromochloropropane (DBCP) on reproductive function, groups of male adult Wistar rats were injected subcutaneously with different doses of DBCP. A strictly dose-dependent effect resulting in histological alteration principally toward the seminiferous tubules was observed. Sperm count and sperm motility showed azoospermia or oligoasthenospermia with a significative recovery in the lower dose of DBCP treated rats. Among the enzymatic activities evaluated as biochemical markers of testicular function: LDH was not appreciably affected by the DBCP treatment while GGT and NADPH-cyt P450-reductase significantly enhanced suggesting an induction of the detoxification processes.
Leone
M
M
Istituto di Clinica Ostetrica e Ginecologica, Università di Genova, Italy.
Costa
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Capitanio
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GL
Palmero
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S
Prati
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Leone
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D000818:Animals; D004305:Dose-Response Relationship, Drug; D004822:Epididymis / Q000187:drug effects; D005298:Fertility / Q000187:drug effects*; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008297:Male; D009251:NADPH-Ferrihemoprotein Reductase / Q000032:analysis; D011407:Propane / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012671:Seminiferous Tubules / Q000187:drug effects; D013076:Sperm Count / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D013739:Testosterone / Q000096:biosynthesis; D005723:gamma-Glutamyltransferase / Q000032:analysis
D013739:Testosterone; C007318:1,2-dibromo-3-chloropropane; D007770:L-Lactate Dehydrogenase; D009251:NADPH-Ferrihemoprotein Reductase; D005723:gamma-Glutamyltransferase; D011407:Propane