Beta-adrenergic receptors of lymphocytes in children with allergic respiratory diseases.
The beta-adrenergic receptor binding sites on peripheral lymphocytes in children with bronchial asthma (n = 16) and seasonal allergic rhinitis (n = 8) were examined in comparison with normal controls (n = 18) by means of 124I-cyanopindolol. The number of beta-adrenergic receptors was significantly lower in the asthmatic group (858 +/- 460/lymphocyte) than in the controls (1564 +/- 983/lymphocyte). The value (1891 +/- 1502/lymphocyte in children with allergic rhinitis was slightly higher than that in healthy controls. Of the 24 patients suffering from allergic diseases of the lower or upper airways, the bronchial histamine provocation test was performed in 21; 16 gave positive results, while 5 were negative. No difference in beta-adrenergic receptor count was found between the histamine-positive and negative patients. Neither was there any correlation between the number of beta-adrenergic receptors and the high (16/24) and low (8/24) serum IgE concentrations found in allergic patients. The significant decrease in beta-adrenergic receptor count in asthmatic children lends support to Szentiványi's concept. Further qualitative and quantitative analysis of lymphocyte beta-adrenergic receptors may provide an individual approach to the treatment of bronchial asthma with beta-sympathomimetic drugs.
Bittera
I
I
Department of Pediatrics, Albert Szent-Györgyi University Medical School, Szeged, Hungary.
Gyurkovits
K
K
Falkay
G
G
Eck
E
E
Koltai
M
M
D000319:Adrenergic beta-Antagonists / Q000378:metabolism; D001249:Asthma / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D002648:Child; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007457:Iodine Radioisotopes; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology
D000319:Adrenergic beta-Antagonists; D007457:Iodine Radioisotopes; D011943:Receptors, Adrenergic, beta; D007073:Immunoglobulin E; C047975:cyanopindolol; D010869:Pindolol