title: The influence of antibiotics on the immune system. II. Modulation of fish leukocyte responses in culture.
abstract: We report the immunomodulating effect of two tetracycline analogues (oxytetracycline and doxycycline) on mitogenic and allogeneic stimulation of carp (Cyprinus carpio) leukocytes in vitro. Both drugs interfered with 3H-thymidine incorporation into the DNA of phytohaemagglutinin-stimulated pronephric leukocytes in a dose-dependent manner. Low concentrations of oxytetracycline delayed the mitogenic response, but did not reduce it. In addition, several other antibiotics were tested for their possible interference with blastogenesis.
authors.forename: J L
authors.initials: JL
authors.lastname: Grondel
authors.forename: A G
authors.initials: AG
authors.lastname: Gloudemans
authors.forename: W B
authors.initials: WB
authors.lastname: van Muiswinkel
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002347:Carps; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004318:Doxycycline / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D007959:Lymphocyte Culture Test, Mixed; D010118:Oxytetracycline / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
chemical_list: D000900:Anti-Bacterial Agents; D010835:Phytohemagglutinins; D014316:Tritium; D004247:DNA; D004318:Doxycycline; D013936:Thymidine; D010118:Oxytetracycline