[The expression of c-myb is strongly associated with the presence of estrogen and progesterone receptors in breast cancer].
The c-myb gene was studied in 112 breast cancers. c-myb and estrogen receptor (ER) transcripts were found in 78 (70%) and 71 (63%) cancers respectively. Of these 71 ER positive cancers, 64 (90%) contained c-myb transcripts and of the 41 ER negative cancers, 27 (66%) did not contain c-myb mRNA. Our data show that c-myb transcripts are strongly associated with ER and progesterone receptors (p less than 10(-4) status in breast cancer. Thus the c-myb expression could be associated with breast cancers of better prognosis and its analysis could allow a better characterization of new subsets of hormono-dependent cancers responding more efficiently to hormonotherapy.
Guerin
M
M
Institut Gustave-Roussy, Laboratoire de Pharmacologie moléculaire, Villejuif.
Barrois
M
M
Riou
G
G
D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism*; D015342:DNA Probes; D005784:Gene Amplification; D006801:Humans; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D020598:Proto-Oncogene Proteins c-myb; D012333:RNA, Messenger / Q000032:analysis; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
D015342:DNA Probes; D011518:Proto-Oncogene Proteins; D020598:Proto-Oncogene Proteins c-myb; D012333:RNA, Messenger; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
L'expression de c-myb est fortement liée à la présence de récepteurs de l'oestrogène et de la progestérone dans les cancers du sein.