Effects of exercise training on biochemical and biomechanical properties of rat aorta.
The authors studied the effect of prolonged physical exercise on the mechanical properties of rat aorta in relation to the amounts and qualities of arterial connective tissue fibrous proteins. Twelve male rats were divided into two groups: 6 sedentary rats (S) and 6 training rats (T), which were forced to swim from nine weeks to twenty-five weeks of age. The ultimate tensile stress and the ultimate tensile extension ratio of ring specimens at the descending thoracic aorta were larger in T than in S (192.3 +/- 47.9 g/mm2, mean +/- SD, vs 147.8 +/- 26.0, p less than 0.05; 3.52 +/- 0.13 vs 3.18 +/- 0.27, p less than 0.05; respectively). The elasticity parameter, calculated by fitting stress-strain curves to exponential function in the stress level of 0-20 g/mm2, was lower in T than in S (1.79 +/- 0.15 vs 2.13 +/- 0.24, p less than 0.01). The contents of elastin (alkali-insoluble elastin preparation) and collagen were higher in T than in S (0.44 +/- 0.11 g/g dry aorta vs 0.30 +/- 0.06, p less than 0.05; 0.15 +/- 0.04 g/g dry aorta vs 0.11 +/- 0.04, NS, respectively). Although the aortic calcium content did not significantly change in the training rats (T 1.17 +/- 0.23 mg/g dry aorta, S 0.95 +/- 0.34), the content of calcium in elastin was lower in T than in S (1.75 +/- 0.51 mg/g dry elastin vs 2.63 +/- 1.00, p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Matsuda
M
M
Institute of Health and Sports Sciences, University of Tsukuba, Ibaraki, Japan.
Nosaka
T
T
Sato
M
M
Iijima
J
J
Ohshima
N
N
Fukushima
H
H
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000502:physiology*; D001696:Biomechanical Phenomena; D002118:Calcium / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D004549:Elastin / Q000378:metabolism*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D005082:Physical Exertion; D051381:Rats; D011921:Rats, Inbred WKY; D013718:Tensile Strength
D000596:Amino Acids; D003094:Collagen; D004549:Elastin; D002118:Calcium