Enhancement of neutrophil adherence to Toxocara canis larvae by the C3 component of complement and IgG antibodies.
In the present study, the binding human neutrophils to Toxocara canis larvae was examined in vitro. It was found that IgG and/or the C3 component of complement were able to enhance the attachment of the cells to the parasites. This was associated with the generation of strong chemiluminescence reactions. Despite the binding of the cells, the larvae were able to escape and to maintain their infectivity. This was apparent, since the parasites could survive and migrate into different organs including the brain after having been inoculated into mice.
Huwer
M
M
Institut für Parasitologie und Tropenveterinärmedizin, Freien Universität Berlin.
Sanft
S
S
Ahmed
J S
JS
D000818:Animals; D002448:Cell Adhesion; D003176:Complement C3 / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007814:Larva / Q000276:immunology / Q000502:physiology; D008163:Luminescent Measurements; D009504:Neutrophils / Q000276:immunology* / Q000502:physiology; D014119:Toxocara / Q000276:immunology* / Q000502:physiology; D014120:Toxocariasis / Q000276:immunology*
D003176:Complement C3; D007074:Immunoglobulin G