Role of gastrin/pentagastrin in regulation of intestinal cytochrome P-450.
1. In the absence of intraluminal inducers, low "basal" levels of cytochrome P-450 and its dependent MFO activities are detected in the rat intestinal mucosa, and may be regulated by endogenous hormones. 2. Rats were nutritionally maintained by either short term (48 hr) intravenous glucose infusion or chronic (8 days) intravenous hyperalimentation, and were treated with various doses of pentagastrin in the infusate. 3. Regardless of the dose (6-90 micrograms/kg/hr) or duration of infusion (2-8 days), pentagastrin had no effect on small intestinal cytochrome P-450, its dependent MFO activity, or the activity of delta-aminolevulinic acid synthetase. 4. The intestinal trophic peptide hormone, gastrin, apparently does not regulate the cytochrome P-450-dependent MFO system of the small intestine.
Pascoe
G A
GA
Department of Pharmacology, University of California, San Francisco 94143.
Correia
M A
MA
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D015660:7-Alkoxycoumarin O-Dealkylase; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004032:Diet; D005755:Gastrins / Q000502:physiology*; D007262:Infusions, Intravenous; D007413:Intestinal Mucosa / Q000166:cytology / Q000201:enzymology; D007422:Intestines / Q000166:cytology / Q000201:enzymology*; D008297:Male; D010105:Oxygenases / Q000378:metabolism; D010288:Parenteral Nutrition; D010418:Pentagastrin / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D005755:Gastrins; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase; D001189:Aryl Hydrocarbon Hydroxylases; D000624:5-Aminolevulinate Synthetase; D010418:Pentagastrin