title: Gluco- and mineralocorticoids may regulate the natriuretic effect and the synthesis and release of atrial natriuretic factor by the rat atria in vivo.
abstract: Adrenalectomy abolished the acute natriuretic effect of ANF which was partially restored to about 50% by combined therapy with gluco- and mineralocorticoids. It is suggested that the lack of effect of ANF may be due to a decreased renal vascular reactivity to the peptide in adrenalectomized animals. Simultaneous administration of Dexamethasone and Deoxycorticosterone acetate to adrenalectomized rats produced a marked increase in immunoreactive ANF in atrial tissue and plasma. The administration of NaCl to these animals produced a relatively lower concentration of atrial ANF and a further increase in plasma ANF. Our results suggest that glucocorticoids may regulate synthesis and release of ANF by the atria and mineralocorticoids may have a permissive role. Furthermore, the presence of steroids is necessary for the NaCl-stimulated ANF release.
authors.forename: R
authors.initials: R
authors.lastname: Garcia
authors.forename: W
authors.initials: W
authors.lastname: Debinski
authors.forename: J
authors.initials: J
authors.lastname: Gutkowska
authors.forename: O
authors.initials: O
authors.lastname: Kuchel
authors.forename: G
authors.initials: G
authors.lastname: Thibault
authors.forename: J
authors.initials: J
authors.lastname: Genest
authors.forename: M
authors.initials: M
authors.lastname: Cantin
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000494:pharmacology / Q000502:physiology*; D003900:Desoxycorticosterone / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology / Q000502:physiology*; D006325:Heart Atria / Q000187:drug effects / Q000378:metabolism; D008901:Mineralocorticoids / Q000494:pharmacology / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism*; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology
chemical_list: D005938:Glucocorticoids; D008901:Mineralocorticoids; C472610:atrial natriuretic peptide, rat; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D003907:Dexamethasone; D009320:Atrial Natriuretic Factor