title: Structure of tumour necrosis factor.
abstract: Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an antiparallel beta-sandwich. Individual subunits from the trimer by a novel edge-to-face packing of beta-sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable similarity to the 'jelly-roll' structural motif characteristic of viral coat proteins.
authors.affiliation: Laboratory of Molecular Biophysics, Oxford, UK.
authors.forename: E Y
authors.initials: EY
authors.lastname: Jones
authors.forename: D I
authors.initials: DI
authors.lastname: Stuart
authors.forename: N P
authors.initials: NP
authors.lastname: Walker
mesh_terms: D015394:Molecular Structure; D011487:Protein Conformation; D014409:Tumor Necrosis Factor-alpha
chemical_list: D014409:Tumor Necrosis Factor-alpha