[The significance of multiple neuromediator activity in supporting integrative brain functions].
Properties were studied of reactions of neural cells of the sensorimotor cortical area to locally microionophoretically administered l-glutamate, acetylcholine, norepinephrine and gamma-aminobutyric acid. It is shown that neuronal reactions to the action of the above-mentioned transmitters differ both in direction of change in the impulse activity frequency and in temporal offracteristics (latency and duration of after-effect). It is substantiated that due to the specificity of temporal ranges of action of the transmitter on neural cells, the possibility of effective interaction and temporal coding of heterofunctional information is provided.
Kotliar
B I
BI
Miasnikov
A A
AA
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D007478:Iontophoresis; D009433:Neural Inhibition / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D005971:Glutamates; D018377:Neurotransmitter Agents; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine; D009638:Norepinephrine
O znachenii polimediatornosti v obespechenii integrativnykh funktsiĭ mozga.