title: Sympatho-adrenal activity and metabolic responses in fasted rats--the role of interscapular brown adipose tissue.
abstract: 1. Sympatho-adrenal (SA) and metabolic responses to fasting were studied in sham-operated (SHAM) rats and in those with interscapular brown adipose tissue (IBAT) removed. 2. Fasting significantly increased adrenaline (A) excretion and serum free fatty acids (FFA), but decreased noradrenaline (NA) excretion and blood glucose level in SHAM rats. 3. IBAT removal did not change metabolic responses while it markedly altered the SA activity. Fasting in animals void of IBAT potentiated the activity of adrenal medulla, inhibited the FFA rise and prevented glucose reduction, which is normally observed in SHAM-fasted rats. 4. Results suggest the significance of IBAT in the regulation of the blood level of energy substrates in fasted rats and in maintaining the basal level of NA excretion.
authors.affiliation: Institute of Physiology and Biochemistry, Faculty of Sciences, University of Belgrade, Yugoslavia.
authors.forename: V
authors.initials: V
authors.lastname: Davidović
authors.forename: N
authors.initials: N
authors.lastname: Dedović
authors.forename: S
authors.initials: S
authors.lastname: Glisić
mesh_terms: D002001:Adipose Tissue, Brown / Q000502:physiology*; D000311:Adrenal Glands / Q000502:physiology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004837:Epinephrine / Q000652:urine; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D013564:Sympathetic Nervous System / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D009638:Norepinephrine; D004837:Epinephrine