[Prognosis and treatment of glomerulonephritis of periarteritis nodosa. The role of plasma exchange].
Fourteen patients with polyarteritis nodosa complicated by histologically confirmed glomerulopathies were included in a prospective multi-center study comparing corticotherapy (group 1, n = 8) with combined cyclophosphamide and steroids (group 2, n = 6). Plasma exchanges were associated on a routine basis. The two groups were comparable apart from initially more severe renal impairment in group 1 (p less than 0.05). Initial control of the disease was obtained in 11 patients (7 from group 1, 4 from group 2) including the patients with oligoanuria. Six patients recovered, 3 had recurrence requiring chronic hemodialysis and 5 patients died from group 1 (p less than 0.05). These preliminary findings suggest that plasma exchange can contribute to control of polyarteritis nodosa with renal complications.
Jarrousse
B
B
Service de Médecine Interne, Hôpital Avicenne, Bobigny.
Guillevin
L
L
Gie
S
S
Bletry
O
O
Barrier
J
J
Cassuto-Viguier
E
E
Ang
K S
KS
Besancenot
J F
JF
Sobel
A
A
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003404:Creatinine / Q000097:blood; D003520:Cyclophosphamide / Q000627:therapeutic use; D005921:Glomerulonephritis / Q000097:blood / Q000188:drug therapy / Q000628:therapy*; D006801:Humans; D015337:Multicenter Studies as Topic; D010951:Plasma Exchange; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D011379:Prognosis; D011446:Prospective Studies
D000305:Adrenal Cortex Hormones; D003520:Cyclophosphamide; D003404:Creatinine
Pronostic et traitement des glomérulonéphrites de la périartérite noueuse. Place des échanges plasmatiques.