5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents.
Balzarini
J
J
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.
van Aerschot
A
A
Herdewijn
P
P
de Clercq
E
E
D000818:Animals; D000998:Antiviral Agents; D002460:Cell Line; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D006678:HIV / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D013937:Thymidine Kinase / Q000037:antagonists & inhibitors; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000031:analogs & derivatives / Q000494:pharmacology
D000998:Antiviral Agents; D015224:Dideoxynucleosides; C058924:3'-fluoro-2',3'-dideoxyuridine; D015215:Zidovudine; C058925:2',3'-didehydro-2',3'-dideoxyuridine; D013937:Thymidine Kinase; C058803:3'-azido-2',3'-dideoxyuridine