title: Percutaneously placed endovascular grafts for aortic aneurysms: feasibility study.
abstract: This limited study addressed the feasibility of treating aneurysms with a new transcatheter endoprosthesis. Aortic aneurysms were experimentally created in six dogs and subsequently bridged with nylon-covered, self-expanding metallic stents. The dogs were followed up for as long as 7 months (median, 22 weeks). In each dog, the graft effectively reconstituted the aortic lumen, excluding the aneurysm. One dog exhibited minimal (less than 1-mm) residual dilatation at the site of the aneurysm 7 months after graft placement. The nylon material acted as a support and template for neointimal encasement, enabling the formation of a new vascular lumen. It also remained porous at the origin of aortic side branches, preserving the visceral blood supply. One of the endovascular grafts failed to expand completely at its distal end, which promoted thrombus formation within the graft and resulted in the occlusion of both renal arteries. The dog was found comatose 48 hours after graft placement and was killed at that time.
authors.affiliation: Department of Diagnostic Radiology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
authors.forename: D
authors.initials: D
authors.lastname: Mirich
authors.forename: K C
authors.initials: KC
authors.lastname: Wright
authors.forename: S
authors.initials: S
authors.lastname: Wallace
authors.forename: T
authors.initials: T
authors.lastname: Yoshioka
authors.forename: D D
authors.initials: DD
authors.lastname: Lawrence
authors.forename: C
authors.initials: C
authors.lastname: Charnsangavej
authors.forename: C
authors.initials: C
authors.lastname: Gianturco
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D001014:Aortic Aneurysm / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D002404:Catheterization / Q000379:methods; D004285:Dogs; D005240:Feasibility Studies; D009757:Nylons; D011474:Prosthesis Design; D013193:Stainless Steel
chemical_list: D009757:Nylons; D013193:Stainless Steel