title: Cyclosporin A in the treatment of severe aplastic anemia: description of a case complicated by the development of tubercular pericarditis during treatment.
abstract: We report on a 62 year-old woman who developed a severe aplastic anemia requiring frequent packed red cell and platelet transfusions. Since conventional pharmacological therapy was ineffective, treatment with Cyclosporin A was started, resulting in a significant increase of leukocyte, platelet, and red cell counts. However, 5 months after the beginning of Cyclosporin A treatment, despite a past medical history not significant for clinical tuberculosis, the patient developed tubercular pericarditis. This report underlines the need for a careful follow-up of Cyclosporin A-treated patients aimed at a prompt diagnosis of possible infectious complications.
authors.affiliation: Institute of Medical Sciences, Milan, Italy.
authors.forename: E M
authors.initials: EM
authors.lastname: Pogliani
authors.forename: M
authors.initials: M
authors.lastname: Cortellaro
authors.forename: P
authors.initials: P
authors.lastname: Foa
authors.forename: A
authors.initials: A
authors.lastname: Iurlo
authors.forename: E E
authors.initials: EE
authors.lastname: Polli
mesh_terms: D000741:Anemia, Aplastic / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D003524:Cyclosporins / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D010493:Pericarditis / Q000209:etiology*; D014376:Tuberculosis / Q000139:chemically induced / Q000150:complications
chemical_list: D003524:Cyclosporins; D007166:Immunosuppressive Agents