Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives.
Some N-(dipeptidyl)-S-acetylcysteamine and N,N'-(dipeptidyl)cystamine salt derivatives were synthesized and evaluated as candidate radioprotector agents. Toxicity and radioprotective activity as the dose reduction factor (DRF) were determined in vivo on mice and compared to N-glycyl-S-acetylcysteamine trifluoroacetate. One of the most interesting compounds of this series was N-glycylglycyl-S-acetylcysteamine trifluoroacetate (8).
Oiry
J
J
Laboratoire de Chimie Bio-Organique, U.A. 488 du CNRS, Université des Sciences et Techniques du Languedoc, Montpellier, France.
Pue
J Y
JY
Imbach
J L
JL
Fatome
M
M
Sentenac-Roumanou
H
H
D000818:Animals; D003538:Cystamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D003543:Cysteamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology; D051379:Mice; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology
D004151:Dipeptides; D011837:Radiation-Protective Agents; D003543:Cysteamine; D003538:Cystamine