title: Evaluation of treatment results of squamous cell carcinoma of the buccal mucosa.
abstract: Of the 49 patients with squamous cell carcinoma of the buccal mucosa referred to the Rotterdam Radio-Therapeutic Institute (RRTI) and Universital Hospital Dijkzigt Rotterdam (AZD) during 1970-1984, 31 patients had an advanced stage of disease, 21 patients had clinical evidence of lymph node metastasis. Forty patients were treated with curative intention. Treatment modalities were: radiation therapy, preoperative radiation followed by surgery, and primary surgery. Eighteen of the 40 patients (45%) developed a local tumor recurrence; nearly all recurrences occurred within 2 years. The incidence was equal in all treatment groups. Of the 22 patients with initial clinically negative neck, regional relapse occurred in 3 of the 14 patients, of whom the neck was not treated electively by radiation therapy; all three in combination with a local recurrence. None of the 8 patients with electively irradiated necks developed a regional relapse. Eight of the 18 patients with initial clinically enlarged lymph nodes treated either by radiotherapy or surgery, developed a regional relapse, 5 in combination with a local recurrence. Treatment of the clinically positive neck by neck dissection was superior to radiotherapy. Local recurrence carried a poor prognosis. Almost 70% died of their disease. The overall and corrected 5-year survival was 38% and 52% respectively.
authors.affiliation: Dept. of Radiotherapy, Dr. Daniel den Hoed Cancer Center, Rotterdam Radio-Therapeutic Institute, University Hospital Dijkzigt, The Netherlands.
authors.forename: L A
authors.initials: LA
authors.lastname: Pop
authors.forename: W M
authors.initials: WM
authors.lastname: Eijkenboom
authors.forename: M F
authors.initials: MF
authors.lastname: de Boer
authors.forename: P C
authors.initials: PC
authors.lastname: de Jong
authors.forename: P
authors.initials: P
authors.lastname: Knegt
authors.forename: P C
authors.initials: PC
authors.lastname: Levendag
authors.forename: C A
authors.initials: CA
authors.lastname: Meeuwis
authors.forename: B A
authors.initials: BA
authors.lastname: Reichgelt
authors.forename: W L
authors.initials: WL
authors.lastname: van Putten
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D009061:Mouth Mucosa; D009062:Mouth Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D009364:Neoplasm Recurrence, Local; D011379:Prognosis