CHOP regimen versus intermittent chlorambucil-prednisone in stage B chronic lymphocytic leukemia. Short term results from a randomized clinical trial. French Cooperative Group on Chronic Lymphocytic Leukemia.
In 1985, the French Cooperative Group on Chronic Lymphocytic Leukemia started a protocol based on the (A, B, C) staging system. This paper reports the first interim results in stage B patients who were randomized to receive either the CHOP regimen or intermittent chlorambucil plus prednisone. Out of the 199 stage B patients, randomized on the reference date of May 1 1988, 94 received chlorambucil plus prednisone (7 deaths) and 105 the CHOP regimen (6 deaths). Among the evaluable patients at the 6-month examination, 53% reached clinical remission or stage A in the chlorambucil-prednisone group while 77% died in the CHOP group (p = 0.002). This short-term result supports the effectiveness of the CHOP regimen previously demonstrated by group in stage C patients. More follow-up is needed to assess the benefit from the CHOP regimen in terms of survival in stage B patients.
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002699:Chlorambucil / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005602:France; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011241:Prednisone / Q000008:administration & dosage; D011897:Random Allocation; D014750:Vincristine / Q000008:administration & dosage
D002699:Chlorambucil; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone