Linoleic-acid-enriched diet: long-term effects on serum lipoprotein and apolipoprotein concentrations and insulin sensitivity in noninsulin-dependent diabetic patients.
Long-term (30 wk) effects on serum lipoproteins and insulin sensitivity of two diets, one with a low polyunsaturated to saturated fat ratio (P:S 0.3) and one with a P:S of 1.0, were compared in 14 patients with noninsulin-dependent diabetes mellitus (NIDDM) in a crossover study. Total and LDL-cholesterol levels declined by 7.6% (p less than 0.01) and 9.8% (p less than 0.01), respectively, during the high P:S diet. VLDL-, HDL2-, and HDL3-cholesterol; triacylglycerol; and apolipoprotein A1, A2, and B levels were not affected by the change in P:S. Despite a modest increase of insulin-mediated glucose disposal at physiologic insulinemia during the high P:S diet, no influence was seen on glycemic control, and on blood glucose, plasma insulin, and C peptide responses to mixed meals. In conclusion, a linoleic-enriched diet in patients with NIDD causes a less atherogenic lipoprotein profile but does not influence glycemic control and carbohydrate tolerance.
Heine
R J
RJ
Department of Internal Medicine, Free University Hospital, Amsterdam, The Netherlands.
Mulder
C
C
Popp-Snijders
C
C
van der Meer
J
J
van der Veen
E A
EA
D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000097:blood*; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000187:drug effects*; D008041:Linoleic Acids / Q000627:therapeutic use*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D001053:Apolipoproteins; D004042:Dietary Fats, Unsaturated; D008041:Linoleic Acids; D008074:Lipoproteins