title: Perseverative responding in male and female Wistar rats: effects of gonadal hormones.
abstract: Response perseveration was investigated in an experimental procedure which has previously been shown to be sensitive to pharmacologically induced behavioral perseveration and response stereotypy. Different groups of intact, gonadectomized, and gonadectomized plus chronically testosterone-treated male and female Wistar rats were exposed to this procedure in which reinforcers were randomly assigned to one of two levers in an operant chamber. One response on the lever to which the reinforcer was assigned was sufficient to produce a food pellet. Response perseveration, defined as the percentage of trials on which more than one response on the lever not selected for reinforcement was made prior to switching to the selected lever was highest in testosterone-treated subjects. Females made more responses on the lever which had been selected for food on the preceding trial, suggesting that females may be more sensitive than males to the consequences of their behavior. This behavioral difference between the sexes may be mediated by the male hormone testosterone.
authors.affiliation: Netherlands Institute for Brain Research, Amsterdam.
authors.forename: A
authors.initials: A
authors.lastname: van Hest
authors.forename: F
authors.initials: F
authors.lastname: van Haaren
authors.forename: N E
authors.initials: NE
authors.lastname: van de Poll
mesh_terms: D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012055:Reinforcement Schedule; D012737:Sex Factors; D013239:Stereotyped Behavior / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D013739:Testosterone