Progesterone antagonist (RU 486) for cervical dilation, labor induction, and delivery in monkeys: effectiveness in combination with oxytocin.
A progesterone antagonist (RU 486), combined with oxytocin, was effective in achieving cervical dilation, labor induction, and early delivery in near-term monkeys. Effects of RU 486 included accelerated flow of colostrum and transiently enhanced weight gain in infants. No overt toxicity on fetuses, mothers, or newborns was detected with the use of a single oral dose of 25 mg.
Wolf
J P
JP
Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Medical College of Hampton Roads, Norfolk 23510.
Sinosich
M
M
Anderson
T L
TL
Ulmann
A
A
Baulieu
E E
EE
Hodgen
G D
GD
D000818:Animals; D002584:Cervix Uteri / Q000187:drug effects*; D003126:Colostrum / Q000276:immunology / Q000378:metabolism; D004359:Drug Therapy, Combination; D004963:Estrenes / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D007136:Immunoglobulins / Q000032:analysis; D007751:Labor, Induced / Q000379:methods*; D007774:Lactation / Q000187:drug effects; D008252:Macaca fascicularis; D015735:Mifepristone; D010121:Oxytocin / Q000494:pharmacology / Q000627:therapeutic use*; D011247:Pregnancy; D011374:Progesterone / Q000037:antagonists & inhibitors*; D015430:Weight Gain
D004963:Estrenes; D007136:Immunoglobulins; D015735:Mifepristone; D011374:Progesterone; D010121:Oxytocin