Linkage analysis of the Duffy blood group marker with several chromosome 1 genes in an extended pedigree with Charcot-Marie-Tooth disease.
We have recently demonstrated tight linkage of the Duffy blood group marker to the alpha-spectrin gene in an extended pedigree with Charcot-Marie-Tooth neuropathy. To determine a more precise location of the Duffy blood group locus on the chromosome 1 map we have tested several more chromosome 1 genes for linkage with this marker. We found suggestive linkage with the antithrombin III and apolipoprotein A2 genes and conclusive linkage with the gene coding for beta-nerve growth factor.
Raeymaekers
P
P
Department of Biochemistry, University of Antwerpen, Belgium.
Van Broeckhoven
C
C
Backhovens
H
H
Wehnert
A
A
Muylle
L
L
De Jonghe
P
P
Gheuens
J
J
Martin
J J
JJ
Vandenberghe
A
A
D001789:Blood Group Antigens / Q000235:genetics*; D002607:Charcot-Marie-Tooth Disease / Q000235:genetics*; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D004375:Duffy Blood-Group System / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D009134:Muscular Atrophy, Spinal / Q000235:genetics*
D001789:Blood Group Antigens; D004375:Duffy Blood-Group System; D005819:Genetic Markers