Stage II papillary clear cell adenocarcinoma of the vagina during observation in a diethylstilbestrol-exposed daughter.
Although many cases of Diethylstilbestrol (DES)-associated clear cell adenocarcinoma (CCA) of the cervix and vagina have occurred, few have arisen in patients whose initial gynecologic evaluation has revealed only nonmalignant DES-related changes. We report a case of a 32-year-old lady who developed a stage II CCA after 8 years of thorough gynecologic examinations. This case substantiates the need for long-term gynecologic assessment in DES daughters.
Carlson
J A
JA
Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia 19104.
Morgan
M
M
Boothby
R
R
Rubin
M
M
D000231:Adenocarcinoma, Papillary / Q000209:etiology / Q000473:pathology*; D000328:Adult; D003131:Combined Modality Therapy; D004054:Diethylstilbestrol; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors; D014625:Vaginal Neoplasms / Q000209:etiology / Q000473:pathology*
D004054:Diethylstilbestrol