title: Are most secondary acute lymphoblastic leukemias mixed acute leukemias?
abstract: A case of acute lymphoblastic leukemia (ALL) secondary to X-ray exposure is reported. The lymphoblasts expressed T-cell and myelomonocytic differentiation-related surface antigens. Clonal chromosomal abnormalities including t(2;12)(q25;q13),-10,der(10), del(11)(q14),der(12) and r were observed. A review of the cytogenetic data suggests that most secondary ALLs, with the exception of Burkitt type ALLs, may be biphenotypic or mixed acute leukemias.
authors.affiliation: Unité INSERM U 301, CNRS, Paris, France.
authors.forename: S J
authors.initials: SJ
authors.lastname: Chen
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Derré
authors.forename: M
authors.initials: M
authors.lastname: Le Coniat
authors.forename: F
authors.initials: F
authors.lastname: Valensi
authors.forename: F
authors.initials: F
authors.lastname: Sigaux
authors.forename: R
authors.initials: R
authors.lastname: Berger
mesh_terms: D000328:Adult; D000943:Antigens, Differentiation / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D015321:Gene Rearrangement; D006650:Histocompatibility Testing; D006801:Humans; D007621:Karyotyping; D015456:Leukemia, Biphenotypic, Acute / Q000209:etiology* / Q000235:genetics; D007953:Leukemia, Radiation-Induced / Q000145:classification* / Q000235:genetics; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification* / Q000209:etiology / Q000235:genetics
chemical_list: D000943:Antigens, Differentiation; D014408:Biomarkers, Tumor