Phospholipase A2 induced diffuse alveolar damage--effect of indomethacin and dexamethasone upon morphology and plasma-histamine level.
Phospholipase A2, injected as a bolus into the jugular vein of adult male Wistar rats was investigated with respect to its action upon lung morphology and blood- plasma- histamine. In comparison with the injection of saline, phospholipase A2 causes hyperemia of the lungs, sequestration of granulocytes and intraalveolar pulmonary edema; the histamine level is increased to the sixfold. Pretreatment of the animals with indomethacin diminishes the toxic effect of phospholipase A2 upon the lungs and the histamine level.
Stömmer
P
P
Pathology Institute, University of Erlangen, Nürnberg.
Steinmann
U
U
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D006632:Histamine / Q000097:blood*; D007213:Indomethacin / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D010740:Phospholipases / Q000494:pharmacology*; D010741:Phospholipases A / Q000494:pharmacology*; D054467:Phospholipases A2; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012128:Respiratory Distress Syndrome / Q000201:enzymology / Q000473:pathology
D003907:Dexamethasone; D006632:Histamine; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; D007213:Indomethacin