Ovarian tumors in pregnancy.
Thirty-eight women were operated for an ovarian tumor diagnosed during pregnancy, with an incidence of 1/2328 deliveries. The diameter of all tumors was above 5 cm. Of the 31 women operated before delivery, seven were untreated and 24 received supportive progestational therapy. The rate of abortions was 85.7% in the untreated group and 10% in the hydroxy-progesterone-caproate group (HPC) (P less than 0.02). When the women received a total dose of HPC of more than 300 mg, 9 of 10 pregnancies reached term with a live child. Two ovarian malignancies were found, 5.3% of all cases. In 42.9% of the women there were fertility problems later in life. Ovarian tumors during pregnancy should be removed as soon as possible, irrespective of the age of the pregnancy. If fully progesterone therapy is given, the danger of abortions is reduced to a minimum. Prophylactic antibiotic treatment should also be administered.
Ashkenazy
M
M
Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.
Kessler
I
I
Czernobilsky
B
B
Nahshoni
A
A
Lancet
M
M
D000077713:17 alpha-Hydroxyprogesterone Caproate; D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000627:therapeutic use; D008525:Medroxyprogesterone / Q000031:analogs & derivatives / Q000627:therapeutic use; D017258:Medroxyprogesterone Acetate; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*; D010052:Ovariectomy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*
D006908:Hydroxyprogesterones; D000077713:17 alpha-Hydroxyprogesterone Caproate; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone