title: A double blind study of vitamin B6 in Down's syndrome infants. Part 1--Clinical and biochemical results.
abstract: Nineteen patients with Down's syndrome participated in a double blind study of the clinical effects of pharmacological doses of vitamin B6 administration, starting under 8 weeks of age and continuing until 3 years of age. Ten patients received the vitamin and nine the placebo. In Part 1 of this study, no statistically significant differences were found between the two groups in mental age, height, weight, cranial circumference or tongue protrusion. A study of side effects conducted on a larger open population found vitamin B6 to be relatively safe when administered over long periods of time with photosensitive blisters as the major complication.
authors.forename: M
authors.initials: M
authors.lastname: Coleman
authors.forename: S
authors.initials: S
authors.lastname: Sobel
authors.forename: H N
authors.initials: HN
authors.lastname: Bhagavan
authors.forename: D
authors.initials: D
authors.lastname: Coursin
authors.forename: A
authors.initials: A
authors.lastname: Marquardt
authors.forename: M
authors.initials: M
authors.lastname: Guay
authors.forename: C
authors.initials: C
authors.lastname: Hunt
mesh_terms: D001768:Blister / Q000139:chemically induced; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004314:Down Syndrome / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007360:Intelligence / Q000187:drug effects; D008297:Male; D011736:Pyridoxine / Q000009:adverse effects / Q000627:therapeutic use*; D012886:Skull / Q000187:drug effects; D014061:Tongue Habits
chemical_list: D011736:Pyridoxine