title: Enhancement of the autologous mixed lymphocyte reaction (AMLR) in children splenectomized after trauma.
abstract: Splenectomized individuals have been reported to have many immunological abnormalities. We have studied the proliferative response of T cells in AMLR of nine children who had undergone splenectomy after trauma. T cells from splenectomized patients showed increased proliferative response in AMLR as compared with that observed in parallelly studied controls (38.480 +/- 19.700 vs 11.160 +/- 3.760 dpm). The percentage of CD4 cells was diminished in the group of splenectomized patients. We found strong correlation between AMLR and time after splenectomy (r = -0.81, p less than 0.01). Possible mechanism of elevated AMLR following splenectomy and hypotheses on generation of AMLR are discussed.
authors.affiliation: Department of Pathophysiology, Military Medical Academy, Lódź.
authors.forename: K
authors.initials: K
authors.lastname: Zeman
authors.forename: H
authors.initials: H
authors.lastname: Tchórzewski
authors.forename: A
authors.initials: A
authors.lastname: Płuzańska
authors.forename: A
authors.initials: A
authors.lastname: Chilarski
authors.forename: E
authors.initials: E
authors.lastname: Majewska
mesh_terms: D000293:Adolescent; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D013154:Spleen / Q000293:injuries*; D013156:Splenectomy