title: Grave's disease. Appearance in cytologic smears from fine needle aspirates of the thyroid gland.
abstract: The cytomorphologic features were analyzed in thyroid samples obtained by fine needle aspiration (FNA) from 54 cases proven to be Grave's disease (toxic goiter) by a multiparameter study. A fire-flare appearance of the follicular cells and a good cellularity of the smears were the features most frequently observed in these cases. Hürthle cell changes were present in 47% of the cases, and small numbers of lymphocytes were seen in smears from 41% of the cases. Epithelioid cell granulomata and multinucleated giant cells were observed in less than one-fourth of the cases. About half of the cases showed some degree of pleomorphism of the follicular cells. Twenty cases of toxic multinodular goiter were similarly analyzed; the features that distinguished this entity from Grave's disease were the absence of epithelioid cells and multinucleated giant cells in the FNA smears.
authors.affiliation: Department of Pathology, Maulana Azad Medical College, New Delhi, India.
authors.forename: G
authors.initials: G
authors.lastname: Jayaram
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.forename: R K
authors.initials: RK
authors.lastname: Marwaha
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D003581:Cytodiagnosis; D003937:Diagnosis, Differential; D005260:Female; D006044:Goiter, Nodular / Q000175:diagnosis / Q000473:pathology; D006111:Graves Disease / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000473:pathology