Absence of a close linkage between Alzheimer's disease susceptibility gene and a polymorphic DNA probe coding for beta-amyloid.
The hypothesis of a connection between Alzheimer's disease (AD) gene and the probe coding for beta-amyloid (beta-A), located on chromosome 21, was investigated in a large study group from Calabria, in which AD was transmitted as an autosomal dominant Mendelian trait. Segregation analysis of one EcoRI restriction polymorphism of beta-A, after molecular hybridization with a long cDNA probe of DNAs from key-individuals in the study group, determined that there was not a close connection between AD and beta-A.
David
F
F
Laboratoire de Génétique Moléculaire, INTS, Paris, France.
Lucotte
G
G
D000544:Alzheimer Disease / Q000235:genetics*; D000682:Amyloid / Q000235:genetics*; D016229:Amyloid beta-Peptides; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis*; D005796:Genes; D006801:Humans; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length
D000682:Amyloid; D016229:Amyloid beta-Peptides; D004247:DNA