title: Valve replacement in children: early and late results.
abstract: In order to analyze the problems associated with prosthetic valve replacement (PVR) in the pediatric population, we have reviewed 29 children, 3.5 to 15 years of age, who were operated upon from 1970 to 1986. The indications were congenital valve malformations in 16 patients, rheumatic valve disease in 7, degenerative disease in 2 and bacterial endocarditis in 4. Ten children underwent aortic valve replacement (AVR), 14 mitral valve replacement (MVR), 1 tricuspid valve replacement and 4 double valve replacement (mitral-aortic in 3 and mitral-tricuspid in 1). Twenty-one mechanical (11 aortic and 10 mitral) and 12 biological prostheses (8 mitral, 2 aortic, and 2 tricuspid) were implanted. There was 1 hospital death (3.4%). Follow-up data were available for all survivors from 3 to 184 months. There were 8 late deaths (5.9% patient-year), 4 among children with mechanical and 4 among those with biological prostheses. Overall actuarial survival at 14 years is 62.5 +/- 10.2% with no significant difference in survival between AVR (77.8 +/- 14%) and MVR (44.4 +/- 16%) (p = 0.31) at 10 years and between recipients of mechanical (65.7 +/- 13%) or biological prostheses (60.0 +/- 15%) (p = 0.62) at 6 years. No documented embolic or anticoagulant-related complications occurred in the entire series.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Cardiovascular Surgery, University of Padova Medical School, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rubino
authors.forename: G
authors.initials: G
authors.lastname: Stellin
authors.forename: A
authors.initials: A
authors.lastname: Mazzucco
authors.forename: U
authors.initials: U
authors.lastname: Bortolotti
authors.forename: G
authors.initials: G
authors.lastname: Rizzoli
authors.forename: G
authors.initials: G
authors.lastname: Faggian
authors.forename: L
authors.initials: L
authors.lastname: Daliento
authors.forename: A
authors.initials: A
authors.lastname: Milano
authors.forename: F
authors.initials: F
authors.lastname: Guerra
authors.forename: V
authors.initials: V
authors.lastname: Gallucci
mesh_terms: D000206:Actuarial Analysis; D001021:Aortic Valve; D001705:Bioprosthesis; D002648:Child; D005260:Female; D006349:Heart Valve Diseases / Q000401:mortality / Q000601:surgery*; D006350:Heart Valve Prosthesis / Q000401:mortality*; D006801:Humans; D008297:Male; D008943:Mitral Valve; D012086:Reoperation; D013997:Time Factors