Early histologic, metabolic, and vascular assessment of anterior cruciate ligament autografts.
A rabbit model for anterior cruciate ligament (ACL) reconstruction using autogenous patellar tendon was utilized to study the early events of autograft cellular dynamics. Biochemical, autoradiographic, histological, and vascular injection techniques demonstrated that the native autograft cell population rapidly necroses. This repopulation occurs without a vascular contribution; cells entering the autograft are reliant upon synovial fluid nutrition.
Kleiner
J B
JB
Division of Orthopaedics and Rehabilitation, University of California, San Diego, La Jolla 92093.
Amiel
D
D
Harwood
F L
FL
Akeson
W H
WH
D000818:Animals; D001345:Autoradiography; D006909:Hydroxyproline / Q000032:analysis; D007719:Knee Joint / Q000378:metabolism* / Q000473:pathology; D008023:Ligaments, Articular / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D008297:Male; D011392:Proline / Q000378:metabolism; D011817:Rabbits; D013709:Tendon Transfer; D014316:Tritium
D014316:Tritium; D011392:Proline; D006909:Hydroxyproline