title: Antioxidants and platelets.
abstract: It is postulated that antioxidants reduce platelet activity by the stimulation of prostacyclin synthetase by scavenging synthesis-inhibiting peroxides. The experimental and clinical evidence supporting this theory is inconclusive. Clinical trials suggest that vitamin E reduced platelet aggregability. Nonexperimentally, a strong association has been observed between low serum selenium concentration and increased platelet aggregability. These findings suggest that antioxidants have an important role in the regulation of platelet function.
authors.affiliation: Department of Community Health and General Practice, University of Kuopio, Finland.
authors.forename: J T
authors.initials: JT
authors.lastname: Salonen
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000008:administration & dosage; D001792:Blood Platelets / Q000187:drug effects*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D014810:Vitamin E / Q000008:administration & dosage
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D001205:Ascorbic Acid