The influence of atenolol and prazosin on serum lipids and atherosclerosis in minipigs fed a hyperlipidemic diet.
1. The effect of the adrenergic blockers prazosin and atenolol were tested in hypercholesterolemic Göttingen minipigs. 2. After 1 yr there was a significant reduction of plasma triglycerides and total cholesterol in the medicated animals as compared to untreated ones. 3. No significant difference in atherosclerotic lesions was observed.
Nafstad
I
I
Department of Pharmacology and Toxicology, Norwegian College of Veterinary Medicine.
Tollersrud
S
S
Eriksen
K
K
Helgeland
A
A
Solberg
L A
LA
Bredesen
J
J
Dale
O
O
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood* / Q000473:pathology; D001262:Atenolol / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004032:Diet; D005260:Female; D005978:Glutathione / Q000097:blood; D006949:Hyperlipidemias / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000473:pathology; D008297:Male; D011224:Prazosin / Q000494:pharmacology*; D013552:Swine; D013556:Swine, Miniature; D014810:Vitamin E / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D002791:Cholesterol, Dietary; D008055:Lipids; D014810:Vitamin E; D001262:Atenolol; D005723:gamma-Glutamyltransferase; D005978:Glutathione; D011224:Prazosin