title: Sister-chromatid exchanges in lymphocytes of workers exposed to trichloroethylene.
abstract: To detect mutagenic effects of trichloroethylene (TCE) on humans, sister-chromatid exchanges (SCEs) were analyzed in lymphocytes of 22 workers occupationally exposed to TCE and 22 matched controls. Although urinalysis in the workers revealed their obvious exposure to TCE, no increase in SCE frequencies was found in lymphocytes of the workers. SCE analysis in lymphocytes could not detect mutagenic effects by occupational exposure to TCE on humans.
authors.affiliation: Department of Public Health, Gifu University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nagaya
authors.forename: N
authors.initials: N
authors.lastname: Ishikawa
authors.forename: H
authors.initials: H
authors.lastname: Hata
mesh_terms: D000328:Adult; D004785:Environmental Pollutants / Q000008:administration & dosage* / Q000652:urine; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000235:genetics* / Q000652:urine; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012907:Smoking / Q000235:genetics; D014241:Trichloroethylene / Q000008:administration & dosage* / Q000652:urine
chemical_list: D004785:Environmental Pollutants; D014241:Trichloroethylene