Reduced 125I-hGH binding by serum of dwarf pigs but not by serum of dwarfed poodles.
1. Normal and growth-deficient poodle and swine strains were characterized for serum growth hormone-binding protein (GH-BP) content as well as other growth-related hormones, and the relationship between these factors and body size was examined. 2. GH-BPs were found in all strains of pigs and poodles. Concentrations of GH-BPs (as expressed by specific bindings) did not vary among the poodle breeds, but did correlate with body size in pigs. 3. Insulin-like growth factors (IGFs) I and II were decreased 71 and 44% respectively in miniature compared to standard size poodles. 4. Only the Yucatan micro pig strain had reduced serum IGF-I concentrations compared to normal controls. 5. Growth hormone concentrations however were normal to elevated in all micro and miniature pig strains. 6. Serum triiodothyronine concentrations were reduced in Yucatan mini and micro pigs in spite of normal circulating levels of thyroxine. 7. Body size reductions in the swine and dog strains are probably attributable to different primary defects of various growth related hormones or hormone receptors. 8. Each species breed therefore could serve as a model for a different human growth-deficient condition.
Lauterio
T J
TJ
Department of Internal Medicine, Eastern Virginia Medical School, Norfolk 23507.
Trivedi
B
B
Kapadia
M
M
Daughaday
W H
WH
D000818:Animals; D001824:Body Constitution; D002352:Carrier Proteins / Q000097:blood; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D004392:Dwarfism / Q000097:blood / Q000662:veterinary*; D013006:Growth Hormone / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000097:blood; D013045:Species Specificity; D013552:Swine; D013553:Swine Diseases / Q000097:blood*; D013556:Swine, Miniature
D002352:Carrier Proteins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; C051815:somatotropin-binding protein