title: Can a 1,2-oxygen shift of a nicotinamide N-oxide derivative occur in vivo?
abstract: Using the N-oxide derivative of niaprazine, a nicotinamide-based drug, as substrate, the possibility of a 1,2-oxygen shift from N to adjacent C occurring in vivo has been investigated. By comparison of the percentage of the 6-pyridone derivative formed after administration of 14C-niaprazine to rats with that obtained after giving 14C-niaprazine N-oxide, it has been shown that a 1,2-oxygen shift might contribute to the formation of 6-pyridone derivatives as metabolites of nicotinamide-related drugs in vivo.
authors.forename: P
authors.initials: P
authors.lastname: Dostert
authors.forename: M
authors.initials: M
authors.lastname: Strolin Benedetti
authors.forename: V
authors.initials: V
authors.lastname: Rovei
authors.forename: R L
authors.initials: RL
authors.lastname: Smith
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats
chemical_list: D002250:Carbon Radioisotopes; D009536:Niacinamide; C037645:nicotinamide N-oxide; C021062:niaprazine