Effect of yohimbine on blood pressure in patients with depression and orthostatic hypotension induced by clomipramine.
Orthostatic hypotension, one of tricyclic antidepressant treatment's side effects, is also a factor in limiting adequate antidepressant dosing. We tested in a double-blind, crossover, placebo-controlled study the effect of low doses (4 mg/t.i.d.) of yohimbine in 12 patients with depression with clomipramine-induced orthostatic hypotension. Yohimbine, a selective alpha 2-adrenoceptor antagonist, had a favorable effect in orthostatic hypotension and induced a significant increase in blood pressure. A pharmacodynamic and pharmacokinetic interaction between yohimbine and clomipramine or demethylclomipramine was discussed.
Lacomblez
L
L
Service de Pharmacologie Clinique, Division Ambroise Paré, Hôpital de la Salpêtrière, Paris, France.
Bensimon
G
G
Isnard
F
F
Diquet
B
B
Lecrubier
Y
Y
Puech
A J
AJ
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002997:Clomipramine / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007024:Hypotension, Orthostatic / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D015016:Yohimbine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
D015016:Yohimbine; D002997:Clomipramine