A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine.
A mouse gene, Cdx-1, was isolated from an embryonic cDNA library using a Drosophila caudal gene probe. The deduced amino acid sequence of Cdx-1 contains conserved sequence domains along the entire gene, as well as a highly conserved caudal-type homeo box. A structural comparison suggests a common ancestral origin of mouse Cdx-1 and Drosophila caudal. The expression of Cdx-1 during embryogenesis was analyzed by Northern blotting and in situ hybridization. Cdx-1-specific transcripts are localized in the epithelial lining of the intestines beginning at 14 days' gestation. The expression of Cdx-1 in the intestine continues into adulthood, but cannot be detected in any other tissues. The Cdx-1 gene is the first homeo-box-containing gene expressed in cells derived from the embryonic endoderm.
Duprey
P
P
Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, FRG.
Chowdhury
K
K
Dressler
G R
GR
Balling
R
R
Simon
D
D
Guenet
J L
JL
Gruss
P
P
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002874:Chromosome Mapping; D004247:DNA; D015342:DNA Probes; D004330:Drosophila / Q000235:genetics*; D004587:Electrophoresis, Agar Gel; D005314:Embryonic and Fetal Development; D005801:Genes, Homeobox; D007422:Intestines / Q000166:cytology / Q000196:embryology*; D051379:Mice; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D014158:Transcription, Genetic
D015342:DNA Probes; D004247:DNA