Radiosensitivity of lymphocytes from patients with Alzheimer's disease.
The response after gamma-irradiation of lymphocytes from 8 patients with Alzheimer's disease (AD), 3 patients with Huntington's disease and 13 normal subjects to stimulation by phytohaemagglutinin (PHA) was assayed by incorporation of [3H]thymidine. The response of non-irradiated cells was found to be significantly lower in AD cells than in age-matched normals but not significantly lower in old normals than in young normals. However, the response of irradiated cells to PHA, expressed as a percentage of that in non-irradiated cells, was found to be similar in AD patients, young and old normals and in HD patients.
Smith
T A
TA
Department of Ophthalmic Optics, University of Manchester Institute of Science and Technology, Great Britain.
Itzhaki
R F
RF
D000328:Adult; D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D002478:Cells, Cultured; D004260:DNA Repair; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000528:radiation effects; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology
D010835:Phytohemagglutinins