title: Sedation and cerebral angiography. The effects of pentazocine and midazolam on arterial carbon dioxide tension.
abstract: A study of the effects of sedation on arterial blood gases in patients undergoing cerebral angiography was performed. Twenty-one patients received pentazocine (30 mg) and midazolam (5-22.5 mg) and arterial carbon dioxide and oxygen tensions were measured from radial artery samples before and during the procedure. A statistically significant rise in arterial carbon dioxide tension was demonstrated. It is suggested that this may cause a rise in intracranial pressure by increasing cerebral blood flow in a group of patients in whom there is a high incidence of raised intracranial pressure. The clinical significance of this increase in arterial carbon dioxide tension is discussed.
authors.forename: P M
authors.initials: PM
authors.lastname: Spargo
authors.forename: W V
authors.initials: WV
authors.lastname: Howard
authors.forename: D A
authors.initials: DA
authors.lastname: Saunders
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001569:Benzodiazepines / Q000494:pharmacology; D002245:Carbon Dioxide / Q000097:blood*; D002533:Cerebral Angiography; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008874:Midazolam; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D010423:Pentazocine / Q000494:pharmacology
chemical_list: D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; D002245:Carbon Dioxide; D008874:Midazolam; D010423:Pentazocine; D010100:Oxygen