Cardiac norepinephrine kinetics in hypertrophic cardiomyopathy.
We examined the uptake and release of norepinephrine in the cardiac circulation and other regional vascular beds in 11 patients with hypertrophic cardiomyopathy (HCM) and in 10 control subjects during simultaneous infusion of tracer-labeled norepinephrine and isoproterenol. Cardiac neuronal uptake of norepinephrine was assessed by comparing regional removal of tracer-labeled norepinephrine with that of tracer-labeled isoproterenol (which is not a substrate for neuronal uptake) and by the relation between production of dihydroxyphenylglycol (DHPG), an exclusively intraneuronal metabolite of norepinephrine, and regional spillover of norepinephrine. Cardiac extraction of norepinephrine averaged 59 +/- 17% in the patients with HCM, significantly less than in the control subjects (79 +/- 13%, p less than 0.05), whereas cardiac extraction of isoproterenol was similar in the two groups (13 +/- 23% versus 13 +/- 14%), indicating that neuronal uptake of norepinephrine was decreased in the patients with HCM. The cardiac arteriovenous difference in norepinephrine was significantly larger in the patients with HCM than in the control subjects (73 +/- 77 versus 13 +/- 50 pg/ml, p less than 0.05), as was the product of the arteriovenous difference in norepinephrine and coronary blood flow (7.3 +/- 7.3 versus 0.8 +/- 3.0 ng/min, p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Brush
J E
JE
Cardiology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Eisenhofer
G
G
Garty
M
M
Stull
R
R
Maron
B J
BJ
Cannon
R O
RO
Panza
J A
JA
Epstein
S E
SE
Goldstein
D S
DS
D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006018:Glycols / Q000096:biosynthesis*; D006801:Humans; D007545:Isoproterenol / Q000493:pharmacokinetics; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives / Q000096:biosynthesis*; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D009638:Norepinephrine / Q000493:pharmacokinetics*; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014316:Tritium
D006018:Glycols; D014316:Tritium; D008734:Methoxyhydroxyphenylglycol; D007545:Isoproterenol; C010117:3,4-dihydroxyphenylglycol; D009638:Norepinephrine