title: Whole body hyperthermia in dogs using a radiant heating device: effect of surface cooling on temperature uniformity.
abstract: Rectal and subcutaneous temperatures were measured during a total of 10 whole body hyperthermia treatments conducted in six dogs. During five of the treatments skin cooling, by means of initiating air flow through the radiant heating device, was necessary during the plateau phase because rectal temperature exceeded the target value. Skin cooling was not necessary in the other five treatments. Although the rectal temperatures were similar in all 10 treatments, extensive and rapid subcutaneous temperature non-uniformity, of approximately 4 degrees C, developed during treatments where skin cooling was necessary. During the treatments where skin cooling was not necessary, the subcutaneous temperature remained approximately equal to the rectal temperature. These data indicate that the environment in the radiant heating device during the plateau phase can have a profound effect on the temperature at superficial sites, which is not reflected by the temperature measured at deeper sites. The temperature at superficial sites should be measured during whole body hyperthermia to assure that the prescribed heat dose is administered to the largest percentage of body mass possible. Active skin cooling during whole body hyperthermia should be avoided if possible.
authors.affiliation: School of Veterinary Medicine, North Carolina State University, Raleigh 27606.
authors.forename: D E
authors.initials: DE
authors.lastname: Thrall
authors.forename: R L
authors.initials: RL
authors.lastname: Page
authors.forename: M W
authors.initials: MW
authors.lastname: Dewhirst
authors.forename: D W
authors.initials: DW
authors.lastname: Macy
authors.forename: D A
authors.initials: DA
authors.lastname: McLeod
authors.forename: R J
authors.initials: RJ
authors.lastname: Scott
authors.forename: S
authors.initials: S
authors.lastname: Allen
authors.forename: E L
authors.initials: EL
authors.lastname: Gillette
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D003131:Combined Modality Therapy; D004285:Dogs; D004317:Doxorubicin / Q000008:administration & dosage*; D006979:Hyperthermia, Induced / Q000295:instrumentation*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000628:therapy*; D012983:Soft Tissue Neoplasms / Q000188:drug therapy / Q000628:therapy*
chemical_list: D004317:Doxorubicin