title: Molecular aspects of sex determination in mice: an alternative model for the origin of the Sxr region.
abstract: Using a combination of in situ mapping and DNA analysis with recombinant DNA probes specific for the Sxr region of the mouse Y chromosome, we show that both the gene(s) controlling primary sex determination and the expression of the male-specific antigen H-Y (Tdy and Hya respectively) are located on the minute short arm of the mouse Y chromosome. We demonstrate that the H-Y- variant of Sxr (Sxr') arose by a partial deletion within the Sxr region and propose an alternative model for the generation of the original Sxr region.
authors.affiliation: Departement d'Immunologie, INSERM U-276, Institut Pasteur, Paris, France.
authors.forename: C E
authors.initials: CE
authors.lastname: Bishop
authors.forename: A
authors.initials: A
authors.lastname: Weith
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: C
authors.initials: C
authors.lastname: Roberts
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D003433:Crosses, Genetic; D003434:Crossing Over, Genetic; D015342:DNA Probes; D005260:Female; D006182:H-Y Antigen / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D008957:Models, Genetic; D012732:Sex Determination Analysis; D014960:X Chromosome; D014998:Y Chromosome
chemical_list: D015342:DNA Probes; D006182:H-Y Antigen