Tyrosine hydroxylase maps to the short arm of chromosome 11 proximal to the insulin and HRAS1 loci.
Tyrosine hydroxylase (TH) is the rate-limiting enzyme for catecholamine biosynthesis and a candidate gene for manic-depressive illness. The TH locus was typed for a BglII RFLP using a cDNA clone Ty7 in four large kindreds. Pairwise analyses and multipoint analyses were carried out to map the TH locus more precisely in the region of the linked markers: D11S12, INS, and HRAS1 on 11p. Results confirm the close linkage between TH with these previously mapped markers and support a most likely ordering which places TH on the side of INS where the centromere lies.
Xue
F
F
Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510.
Kidd
J R
JR
Pakstis
A J
AJ
Castiglione
C M
CM
Mallet
J
J
Kidd
K K
KK
D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D004262:DNA Restriction Enzymes; D005260:Female; D005796:Genes; D011905:Genes, ras; D008040:Genetic Linkage; D006801:Humans; D007328:Insulin / Q000235:genetics*; D008126:Lod Score; D008297:Male; D010375:Pedigree; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
D007328:Insulin; D014446:Tyrosine 3-Monooxygenase; D004262:DNA Restriction Enzymes