Intestinal disaccharidases assessed in congenital asucrasia by differential urinary disaccharide excretion.
A patient with congenital asucrasia was investigated using in vivo differential urinary disaccharide excretion. Impaired hydrolysis of sucrose and isomaltose, but normal lactase activity, were demonstrated and confirmed by in vitro estimation. The technique of differential disaccharide excretion can now be used to assess three disaccharidases simultaneously, in vivo, including isomaltase.
Maxton
D G
DG
Gastrointestinal Laboratory, St. Thomas' Hospital, London, U.K.
Catt
S D
SD
Menzies
I S
IS
D000328:Adult; D002239:Carbohydrate Metabolism, Inborn Errors / Q000652:urine*; D004186:Disaccharidases / Q000378:metabolism; D004187:Disaccharides / Q000652:urine*; D006801:Humans; D007583:Jejunum / Q000201:enzymology; D008297:Male; D009097:Multienzyme Complexes / Q000172:deficiency*; D013394:Sucrase-Isomaltase Complex / Q000172:deficiency*; D013395:Sucrose / Q000378:metabolism*
D004187:Disaccharides; D009097:Multienzyme Complexes; D013395:Sucrose; D004186:Disaccharidases; D013394:Sucrase-Isomaltase Complex