Correlation of class I DNA Pvu II restriction HLA gene fragments with serologic alleles.
Restriction enzyme site polymorphisms for Pvu II endonuclease are examined in a panel of DNAs isolated from peripheral blood lymphocytes of HLA-typed individuals. 21 polymorphic bands are detected from a total of 39 restriction fragments analyzed, only 9 of them corresponding to common variable morphs. Three polymorph fragments only correlate with known HLA-A and -B serologic alleles.
Lucotte
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G
Laboratoire de Génétique Moléculaire du CNTS-Institut, Paris, France.
Coulondre
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C
Salmon
C
C
D000483:Alleles; D004247:DNA / Q000032:analysis; D015252:Deoxyribonucleases, Type II Site-Specific; D005805:Genes, MHC Class I; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D005810:Multigene Family; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length
D006680:HLA Antigens; D004247:DNA; C025630:CAGCTG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific