Diagnosis of trisomy 18 in monozygotic twins by cordocentesis.
The incidence of monozygotic twins with trisomy 18 is 1 in 1,000,000 births. We report a case diagnosed prenatally with lymphocyte culture from fetal blood samples obtained by cordocentesis. Fetal growth lag and structural malformations detected by ultrasonography indicated chromosomal abnormality. A saline solution infusion technique ensured that cordocentesis obtained a sample from each twin.
Shah
D M
DM
Division of Maternal-Fetal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Jeanty
P
P
Dev
V G
VG
Ulm
J E
JE
Phillips
J
J
D000328:Adult; D002478:Cells, Cultured; D002887:Chromosomes, Human, Pair 18; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D006801:Humans; D007231:Infant, Newborn; D008214:Lymphocytes; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014314:Trisomy; D014427:Twins; D014430:Twins, Monozygotic