title: The 2-desamino and 2-desamino-2-methyl analogues of aminopterin do not inhibit dihydrofolate reductase but are potently toxic to tumor cells in culture.
authors.affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.
authors.forename: A
authors.initials: A
authors.lastname: Rosowsky
authors.forename: R A
authors.initials: RA
authors.lastname: Forsch
authors.forename: J H
authors.initials: JH
authors.lastname: Freisheim
authors.forename: R G
authors.initials: RG
authors.lastname: Moran
mesh_terms: D000630:Aminopterin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002470:Cell Survival / Q000187:drug effects; D005493:Folic Acid Antagonists; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000201:enzymology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; C058707:2-desaminopterin; C058706:2-desamino-2-methylaminopterin; D000630:Aminopterin