title: Side effects of self-administration of intracavernous papaverine and phentolamine for the treatment of impotence.
abstract: Beginning October 1985, 111 men agreed to enter a prospective study of the side effects of low dose papaverine/phentolamine therapy. A total of 46 men dropped out, 30 during the initial phase. The percentage of men with painless nodules almost consistently doubled from one followup examination to the next: 8 per cent at 1 month, 17 per cent at 3 months, 32 per cent at 6 months and 57 per cent at 12 months. The average injection frequency of those with nodules was 2 1/2 times higher than those without nodules. Of the men 41 per cent required an increased dose of medications during followup, and 40 per cent of 50 men had at least 1 abnormality of liver function, most of these involving mild to moderate elevations of alkaline phosphatase and lactic dehydrogenase. Priapism was not encountered during self-injection but it did occur twice in 329 physician-administered injections. Careful regular monitoring of patients should continue as some patients enter the second year of treatment.
authors.affiliation: Department of Psychiatry, University Hospitals of Cleveland, Ohio.
authors.forename: S B
authors.initials: SB
authors.lastname: Levine
authors.forename: S E
authors.initials: SE
authors.lastname: Althof
authors.forename: L A
authors.initials: LA
authors.lastname: Turner
authors.forename: C B
authors.initials: CB
authors.lastname: Risen
authors.forename: D R
authors.initials: DR
authors.lastname: Bodner
authors.forename: E D
authors.initials: ED
authors.lastname: Kursh
authors.forename: M I
authors.initials: MI
authors.lastname: Resnick
mesh_terms: D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D007267:Injections / Q000009:adverse effects; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000008:administration & dosage / Q000009:adverse effects*; D010410:Penile Erection / Q000187:drug effects; D010411:Penile Induration / Q000139:chemically induced*; D010646:Phentolamine / Q000008:administration & dosage / Q000009:adverse effects*; D011317:Priapism / Q000139:chemically induced; D011446:Prospective Studies; D012646:Self Administration
chemical_list: D010208:Papaverine; D010646:Phentolamine