title: Nyquil-associated liver injury.
abstract: Acetaminophen, a commonly used medication, is present in many over-the-counter remedies. In recent years, its potential to cause severe liver injury has been increasingly appreciated. Chronic abusers of alcohol may be particularly susceptible to hepatotoxicity from acetaminophen. We report two cases of unintentional liver injury associated with ingestion of Nyquil, a liquid cold remedy containing acetaminophen and 25% alcohol.
authors.affiliation: University of Miami School of Medicine, Florida.
authors.forename: R T
authors.initials: RT
authors.lastname: Foust
authors.forename: K R
authors.initials: KR
authors.lastname: Reddy
authors.forename: L J
authors.initials: LJ
authors.lastname: Jeffers
authors.forename: E R
authors.initials: ER
authors.lastname: Schiff
mesh_terms: D000082:Acetaminophen / Q000506:poisoning*; D000328:Adult; D000437:Alcoholism / Q000150:complications; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D003915:Dextromethorphan / Q000506:poisoning*; D004319:Doxylamine / Q000506:poisoning*; D004338:Drug Combinations / Q000506:poisoning; D004809:Ephedrine / Q000506:poisoning*; D005260:Female; D006801:Humans; D007981:Levorphanol / Q000031:analogs & derivatives*; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D004366:Nonprescription Drugs / Q000506:poisoning*; D011398:Promethazine / Q000506:poisoning*; D054199:Pseudoephedrine; D011725:Pyridines / Q000506:poisoning*
chemical_list: D004338:Drug Combinations; D004366:Nonprescription Drugs; C045626:Nyquil; D011725:Pyridines; D007981:Levorphanol; D000082:Acetaminophen; D003915:Dextromethorphan; D054199:Pseudoephedrine; D004319:Doxylamine; D011398:Promethazine; D004809:Ephedrine