[Interaction of the plasma membranes of the cells of tumors metastasizing to the lungs with the target organ].
Cells of lines of mice transplantable tumours metastasizing into the lung have been used: lung adenocarcinoma (AL), Lewis lung carcinoma (LL), melanoma B-16 (B-16), mammary tumour MMT-1 (MMT-1), malignant subline of L-cells (LS). Hybrid vesicles were obtained for each tumour. They contain fragments of cell plasmatic membranes (PM). It has been shown that AL-, LL-, LS- and B-16-liposomes were accumulated in lung, the trapping of AL- and LL-liposomes being higher than that of the other hybrid vesicles. Despite the similar dynamics and frequency of metastatic spreading into the lung for all tumours studied, no trapping of MMT-1-vesicles in the target-organ was observed. The role of specific interaction of tumour cells PM with the endothelium of the lung capillaries in the process of organotropic metastatic spreading is discussed.
Zolotareva
A G
AG
Nikolin
V P
VP
Iunker
V M
VM
Gruntenko
E V
EV
Budker
V G
VG
Subbotin
V M
VM
D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary; D000818:Animals; D002450:Cell Communication; D002462:Cell Membrane / Q000473:pathology; D005260:Female; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D008546:Melanoma, Experimental / Q000473:pathology / Q000556:secondary; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology*
Vzaimodeĭstvie plazmaticheskikh membran kletok opukholeĭ, metastaziruiushchikh v legkie, s organom-mishen'iu.