title: Ultraviolet irradiation of platelet concentrate abrogates lymphocyte activation without affecting platelet function in vitro.
abstract: We studied the effect of ultraviolet (UV) radiation on platelet concentrates. Samples irradiated at 310 mm for 30 minutes at a dose of 1782 J per m2 showed no loss of platelet function in vitro as determined by adenosine diphosphate, collagen, or ristocetin-induced aggregation. Lymphocytes isolated from irradiated units were unable to act as responders or stimulators in a mixed-lymphocyte reaction. These data suggest that UV radiation of platelet concentrates may result in a cell suspension that is unable to evoke an immunological response.
authors.forename: R A
authors.initials: RA
authors.lastname: Kahn
authors.forename: B F
authors.initials: BF
authors.lastname: Duffy
authors.forename: G G
authors.initials: GG
authors.lastname: Rodey
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000502:physiology / Q000528:radiation effects*; D001803:Blood Transfusion; D003094:Collagen / Q000494:pharmacology; D006801:Humans; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D010974:Platelet Aggregation / Q000187:drug effects; D017713:Platelet Transfusion; D012310:Ristocetin / Q000494:pharmacology; D014466:Ultraviolet Rays
chemical_list: D012310:Ristocetin; D000244:Adenosine Diphosphate; D003094:Collagen