[Effects of corazol on the dynamics of membrane-bound calcium in the structures of the cerebral cortex].
Using the complex methodical approach on the basis of in vivo microscopy and chlortetracycline fluorescent probe of the cat brain cortex preparation the authors studied the changes in the content of the bound calcium in the structures of II-III motor cortex layers in response to influence by metrasol. Correlation between rapid decrease of some part of the bound calcium and development of neuron seizures was discovered. Moreover process of calcium absorption by intracellular membranes in response to influence of metrasol in high doses was revealed. Apparently functional different intracellular membranes are involved in this process.
Samoĭlov
M O
MO
Sofronov
G A
GA
Alekseev
M G
MG
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002415:Cats; D002751:Chlortetracycline; D003292:Convulsants / Q000008:administration & dosage / Q000494:pharmacology*; D005456:Fluorescent Dyes; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000378:metabolism*; D009044:Motor Cortex / Q000187:drug effects* / Q000378:metabolism; D010433:Pentylenetetrazole / Q000008:administration & dosage / Q000494:pharmacology*
D003292:Convulsants; D005456:Fluorescent Dyes; D002118:Calcium; D002751:Chlortetracycline; D010433:Pentylenetetrazole
Vliianie korazola na dinamiku soderzhaniia membranno-sviazannogo kal'tsiia v strukturakh kory golovnogo mozga.