title: Fracture patterns in two types of autosomal-dominant osteopetrosis.
abstract: Thirty-five individuals with autosomal-dominant osteopetrosis were interviewed and radiographs were reviewed. Twenty had the radiographic Type I osteopetrosis, characterized by diffuse, symmetric osteosclerosis and pronounced sclerosis of the skull with a thickened cranial vault. Fifteen had Type II, where the most striking findings were diffuse symmetric osteosclerosis, "Rugger Jersey Spine," and endobones (bone within a bone) in the pelvis, while the cranial vault was almost unaffected. Of the 12 probands who had had a fracture, 2/20 were Type I and 10/15 were Type II. Fracture complications were also more frequent in Type II.
authors.affiliation: Department of Internal Medicine, Svendborg Hospital, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Bollerslev
authors.forename: P E
authors.initials: PE
authors.lastname: Andersen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005598:Fractures, Spontaneous / Q000000981:diagnostic imaging* / Q000209:etiology; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D008875:Middle Aged; D010022:Osteopetrosis / Q000150:complications* / Q000235:genetics; D011859:Radiography