title: The metabolism of tromantadine.
abstract: The metabolism of the antiviral drug tromantadine (1-adamantyl-2-(2-dimethylaminoethoxy)acetamide) was studied after an oral dose of 120 mg tromantadine hydrochloride using capillary gas chromatography/mass spectrometry. Most of the dose was excreted unchanged with the urine. Six metabolites could be identified. The main metabolic products were 1-aminoadamantane (amantadine) and 1-adamantyl-(2-hydroxy)acetamide. Further metabolic pathways were demethylation of the dimethylamino function and oxidative desamination to an unstable aldehyde which is oxidized to a carbonic acid or reduced to an alcohol.
authors.forename: C
authors.initials: C
authors.lastname: Köppel
authors.forename: J
authors.initials: J
authors.lastname: Tenczer
authors.forename: E
authors.initials: E
authors.lastname: Rütten
authors.forename: F
authors.initials: F
authors.lastname: Klaschka
mesh_terms: D000107:Acetylation; D000547:Amantadine / Q000031:analogs & derivatives* / Q000378:metabolism; D000998:Antiviral Agents / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans
chemical_list: D000998:Antiviral Agents; D000547:Amantadine; C004279:tromantadine