Effect of immunoglobulin M from normal human serum on Leishmania donovani promastigote agglutination, complement-mediated killing, and phagocytosis by human monocytes.
Serum from healthy, nonimmune humans contained immunoglobulin M (IgM) antibodies that agglutinated Leishmania donovani promastigotes, activated complement, and enhanced promastigote ingestion by human monocytes. The findings indicate that IgM antibodies have the capacity to affect the initial interaction of L. donovani promastigotes with human host defenses.
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Department of Medicine, University of Virginia School of Medicine, Charlottesville 22908.
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Pearson
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D000328:Adult; D000371:Agglutination; D000818:Animals; D003167:Complement Activation; D006801:Humans; D007075:Immunoglobulin M / Q000502:physiology*; D007893:Leishmania donovani / Q000254:growth & development / Q000276:immunology*; D009000:Monocytes / Q000276:immunology* / Q000469:parasitology; D010587:Phagocytosis
D007075:Immunoglobulin M