Lymphocyte subpopulations in ataxia-telangiectasia.
Peripheral blood lymphocyte subsets were analyzed in nine patients with ataxia-telangiectasia (AT) and their immediate family members. Absolute lymphocyte numbers were slightly low. T-helper/inducer cell, as well as B-cell, percentages were comparable to normal in patients with AT. The percentage of T-suppressor/cytotoxic cells was decreased in five of nine patients. The percentage of large granular lymphocytes was elevated in three patients. No generalities consistent with a disease hypothesis could be made on the basis of lymphocyte subpopulation data.
Weaver
M
M
Gatti
R A
RA
D001260:Ataxia Telangiectasia / Q000097:blood*; D001402:B-Lymphocytes; D006801:Humans; D007694:Killer Cells, Natural; D007958:Leukocyte Count; D013601:T-Lymphocytes; D006377:T-Lymphocytes, Helper-Inducer; D050378:T-Lymphocytes, Regulatory