[Gamma-glutamyltransferase activity in the serum and the mean-cell erythrocyte volume of patients with chronic ethylism and chronic liver diseases (preliminary report)].
The dynamics of the enzyme gamma-glutamyltransferase (gamma GT) was followed up in 34 patients: 17 patients with liver cirrhosis, 9 patients with chronic hepatitis and 8 patients with liver steatosis. In the patients with alcoholic cirrhosis the activity of gamma GT rapidly fell in hospital conditions which is related to the forced abstinence. In the cirrhotic patients with nonalcoholic etiology no changes in gamma GT activity were found. In the patients with chronic hepatitis and liver steatosis with alcoholic etiology the gamma GT activity resembled that of alcoholic cirrhotic patients. The gamma GT activity fell most sharply in the patients with liver steatosis which is explained by the mild and reversible liver lesions characteristic for this disease. The mean erythrocyte volume determined by electronic blood cell counter shows a tendency toward macrocytosis in all chronic alcoholic patients. Macrocytosis is also found by ordinary microscopic examination of the blood cells.
Penev
P
P
Penev
M
M
Georgiev
I
I
Popov
G
G
Dukova-Peneva
P
P
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D004796:Clinical Enzyme Tests; D004909:Erythrocyte Indices; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D005723:gamma-Glutamyltransferase / Q000097:blood*
D015415:Biomarkers; D005723:gamma-Glutamyltransferase
Prouchvaniia otnosno aktivnostta na gama-glutamiltransferazata v seruma i sredniia eritrotsiten obem pri bolni s khronichen etilizŭm i khronichni chernodrobni zaboliavaniia (predvaritelno sŭobshtenie).