Action of clonazepam and clorazepate on cortical self-sustained after-discharges in the rat.
Self-sustained after-discharges (SSADs) induced by electric stimulation of the sensorimotor cortex in rats exhibited under control conditions a significant progressive prolongation with repeated stimulations. Clonazepam not only blocked this increase in duration but it suppressed and/or abolished SSADs in a dose-dependent manner. Clorazepate in the lowest dose used (10 mg/kg) did not change SSADs. The two higher doses (25 and 50 mg/kg) blocked the prolongation of the 4th SSAD, i.e. this effect had a relatively long latency.
Heidler
I
I
Institute of Physiology, Faculty of Medicine, Charles University, Prague, Czechoslovakia.
Mares
J
J
Trojan
S
S
Mares
P
P
Vorlícek
J
J
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D002998:Clonazepam / Q000494:pharmacology*; D003009:Clorazepate Dipotassium / Q000494:pharmacology*; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004827:Epilepsy / Q000188:drug therapy; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D014151:Anti-Anxiety Agents; D002998:Clonazepam; D003009:Clorazepate Dipotassium