Increased frequency of sister-chromatid exchange induced by dothistromin in CHO cells and human lymphocytes.
Dothistromin is a metabolite produced by Dothistromin pini and Cercospora arachidicola. The latter fungus is a pathogen of the peanuts and thus the mycotoxin may be a contaminant of foodstuffs. Dothistromin induces a dose-dependent increase in sister-chromatid exchange frequency in Chinese hamster ovary cells and stimulated human lymphocytes. The increased frequency in human lymphocytes seen with dothistromin is significantly higher among lymphocytes from smokers compared with those from non-smokers.
Skinnider
L
L
Department of Pathology, University of Saskachewan, Saskatoon, Canada.
Stoessl
A
A
Wang
J
J
D000818:Animals; D000880:Anthraquinones / Q000633:toxicity*; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008937:Mitomycins; D009183:Mycotoxins / Q000633:toxicity*; D010053:Ovary; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012907:Smoking / Q000235:genetics
D000880:Anthraquinones; D008937:Mitomycins; D009183:Mycotoxins; C042735:dothistromin