[DNA analysis by flow cytometry in breast carcinoma].
Using deparaffinized tumor specimens, a flow cytometric DNA analysis was performed in 63 primary breast cancers from patients who were treated from 1976 through 1982. Fourty-three percent of the cases were found to be aneuploid, and 57% were diploid. No trend to increased aneuploid proportion with a more advanced disease was noted. There was no correlation between the level of ploidy and the clinicopathological factors. Aneuploid tumors seem to have a poorer survival, but no significant difference was found between the two patterns of ploidy. Patients with a low S-phase fraction (SPF) had a significantly longer survival than those with a high SPF. A DNA analysis of the tumor cells in breast cancer is felt to be use for a prognostic evaluation.
Tsuchiya
A
A
2nd Dept. of Surgery, Fukushima Med. College.
Sekikawa
K
K
Sato
H
H
Ando
Y
Y
Suzuki
S
S
Nihei
M
M
Rokkaku
Y
Y
Nomizu
T
T
Kimijima
I
I
Abe
R
R
D000782:Aneuploidy; D001943:Breast Neoplasms / Q000032:analysis / Q000401:mortality / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis* / Q000235:genetics; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007399:Interphase; D009367:Neoplasm Staging
D004273:DNA, Neoplasm