Interaction of ketamine with atracurium.
The effect of ketamine on the duration of atracurium-induced neuromuscular blockade was studied in 40 healthy patients anaesthetized with midazolam, fentanyl and nitrous oxide. Twenty received, in addition, i.v. ketamine 2 mg kg-1 followed by an infusion of 2 mg kg-1 h-1. Atracurium 0.5 mg kg-1 was injected i.v. and the time to 25% recovery of the twitch height was measured. It was 8.0 min longer in the ketamine group (P less than 0.005), with a 95% confidence interval of from 2.3 to 11.8 min.
Toft
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P
Odense University Hospital, Department of Anaesthesiology, Denmark.
Helbo-Hansen
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S
D001279:Atracurium / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007649:Ketamine / Q000494:pharmacology*; D009407:Nerve Block; D009469:Neuromuscular Junction / Q000187:drug effects*; D013997:Time Factors
D001279:Atracurium; D007649:Ketamine