Treatment of antigen-induced arthritis in rabbits with dysprosium-165-ferric hydroxide macroaggregates.
Dysprosium-165-ferric hydroxide macroaggregates (165Dy-FHMA) was used as an agent of radiation synovectomy in an antigen-induced arthritis model in New Zealand white rabbits. Animals were killed up to 6 months after treatment. 165Dy-FHMA was found to have a potent but temporary antiinflammatory effect on synovium for up to 3 months after treatment. Treated knees also showed significant preservation of articular cartilage architecture and proteoglycan content compared with untreated controls, but only during the first 3 months after treatment. In animals killed 3 and 6 months after treatment there were only minimal differences between the treated and untreated knees, indicating that the antiinflammatory effects on synovial tissue and articular cartilage preservation were not sustained.
Zuckerman
J D
JD
Center for Arthritis Management, Hospital for Joint Diseases Orthopaedic Institute, New York, New York 10003.
Sledge
C B
CB
Shortkroff
S
S
Venkatesan
P
P
D000818:Animals; D000941:Antigens; D001168:Arthritis / Q000532:radiotherapy*; D001169:Arthritis, Experimental / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D001918:Brachytherapy; D002358:Cartilage, Articular / Q000473:pathology; D004337:Drug Carriers; D004419:Dysprosium / Q000008:administration & dosage / Q000627:therapeutic use*; D005290:Ferric Compounds; D005355:Fibrosis; D006965:Hyperplasia; D007719:Knee Joint / Q000000981:diagnostic imaging; D010047:Ovalbumin; D010316:Particle Size; D011817:Rabbits; D011859:Radiography; D011868:Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*; D013583:Synovial Membrane / Q000473:pathology
D000941:Antigens; D004337:Drug Carriers; D005290:Ferric Compounds; D011868:Radioisotopes; D004419:Dysprosium; C021024:ferric hydroxide; D010047:Ovalbumin