title: Tris acetylacetonate aluminium(III) induces osmotic fragility and acanthocyte formation in suspended erythrocytes.
abstract: Tris acetylacetonate aluminium(III) (Al(acac)3), dissolved in water, is effective in producing osmotic fragility in suspended erythrocytes in the concentration range of 0.034-0.34 mmol/l. Water solutions of Tris maltolate aluminium(III) (Al(malt)3) and aluminium lactate (Al(lac)3) are also effective but the dose-response behavior is less pronounced. Moreover, only Al(acac)3 induces a prominent generation of acanthocytes. The stronger effects of Al(acac)3 on membrane stability are attributed to the greater solubility of this complex in the cell membrane.
authors.affiliation: Centro CNR per lo Studio delle Emocianine ed altre Metalloproteine, Padova, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Zatta
authors.forename: M
authors.initials: M
authors.lastname: Perazzolo
authors.forename: B
authors.initials: B
authors.lastname: Corain
mesh_terms: D000050:Acanthocytes / Q000187:drug effects*; D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000648:ultrastructure; D004913:Erythrocytes, Abnormal / Q000187:drug effects*; D007659:Ketones / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D009942:Organometallic Compounds / Q000494:pharmacology*; D009996:Osmotic Fragility / Q000187:drug effects*; D010422:Pentanones / Q000494:pharmacology*; D011817:Rabbits; D012995:Solubility
chemical_list: D007659:Ketones; D009942:Organometallic Compounds; D010422:Pentanones; C058508:tris(acetylacetonate) aluminum(III); D000535:Aluminum