title: Effect of lidocaine on forebrain ischemia in rats.
abstract: We examined the effect of lidocaine on ischemic neuronal injury in the rat forebrain ischemia model. Cerebral ischemia was achieved with bilateral carotid artery occlusion and controlled hypotension to a mean of 50 torr for 10 minutes. Perfusion-fixation was performed 7 days after ischemia, subsequent to which the brains were sectioned coronally and stained with hematoxylin and eosin. Ischemic neuronal injury was quantitatively expressed (after direct counting) as a percentage of total neurons, that is, ischemic neurons divided by (ischemic neurons + normal neurons). Predictably, the selectively vulnerable hippocampal areas exhibited the most marked neuronal injury. In the CA1/CA2 sectors, lidocaine-treated rats demonstrated less injury (34 +/- 14%) than untreated (64 +/- 9%) or saline-treated (70 +/- 10%) rats. However, these superficially pronounced numerical differences were not of statistical significance (p greater than 0.05). In the CA3 sector, neuronal injury in lidocaine-treated rats (31 +/- 14%) was significantly different at p less than 0.05 from the untreated (80 +/- 5%) but not the saline-treated (59 +/- 13%) group. We conclude that lidocaine may have an only marginal beneficial effect on forebrain ischemia in rats.
authors.affiliation: Department of Pharmacology, University of Manitoba, Winnipeg, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Sutherland
authors.forename: B Y
authors.initials: BY
authors.lastname: Ong
authors.forename: D
authors.initials: D
authors.lastname: Louw
authors.forename: A A
authors.initials: AA
authors.lastname: Sima
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D004027:Diencephalon / Q000098:blood supply; D008012:Lidocaine / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D009474:Neurons / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013687:Telencephalon / Q000098:blood supply
chemical_list: D008012:Lidocaine