[Early post-toxic defects in hepatocyte membranes revealed by electron microscopy with the aid of a lanthanum transmembrane tracer].
At early stages of CCl4 treatment defects of hepatocyte membranes are formed as a result of free radical oxidation lipids and Ca2+ accumulation by cells from extracellular media. The formation of membrane's pores precedes the development of ultrastructural changes of hepatocytes during CCl4 treatment and this is the result of membrane damage.
Vakulin
G M
GM
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology*; D003593:Cytoplasm / Q000648:ultrastructure; D007811:Lanthanum; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains
D007811:Lanthanum
Rannie posttoksicheskie defekty v membranakh gepatotsitov, vyiavliaemye élektronno-mikroskopicheski s pomoshch'iu lantanovogo transmembrannogo treĭsera.