title: Variations in the friction coefficients of tablet lubricants and relationship to their physicochemical properties.
abstract: A previously described modified annular shear cell (MASC) has been used to measure the friction coefficients of some powdered tablet lubricants on a steel surface. Commonly used lubricants, as well as others belonging to the stearate group, differed in their friction coefficients at equivalent sample sizes and in the degree of their ability to reduce friction with increasing amounts when evaluated by the apparatus. In all comparisons, magnesium stearate had the lowest friction coefficient. Divalent salts of stearic acid appeared to be better than the other lubricants tested, and among themselves differed only in the extent of their ability to decrease friction. The lubricants also differed in their physical and chemical properties. On evaluation by stepwise regression analysis, such physical properties as projected surface area of lubricant particles, Martin's diameter and bulk density accounted for most of the variation in friction coefficients of the lubricants rather than moisture content or melting point. It could therefore be suggested that particle size and/or surface area parameters be incorporated in product specifications to ensure reproducible functionality.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, University of Maryland, Baltimore 21201.
authors.forename: A R
authors.initials: AR
authors.lastname: Baichwal
authors.forename: L L
authors.initials: LL
authors.lastname: Augsburger
mesh_terms: D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D005079:Excipients; D008153:Lubrication; D010316:Particle Size; D013607:Tablets
chemical_list: D005079:Excipients; D013607:Tablets