Anaphylactic symptoms due to chlorhexidine gluconate.
Six patients who developed urticaria, dyspnea, and anaphylactic shock due to topical application of chlorhexidine gluconate solution are described. Chlorhexidine gluconate was confirmed as the causative agent of type I hypersensitivity by intradermal, scratch, and epicutaneous tests. To prevent life-threatening adverse reactions, it seems important to use chlorhexidine gluconate on wound surfaces at a concentration of 0.05%, as recommended by the manufacturer; chlorhexidine gluconate may not be suitable for application to mucous membranes.
Okano
M
M
Department of Dermatology, Osaka University School of Medicine, Japan.
Nomura
M
M
Hata
S
S
Okada
N
N
Sato
K
K
Kitano
Y
Y
Tashiro
M
M
Yoshimoto
Y
Y
Hama
R
R
Aoki
T
T
D000293:Adolescent; D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced*; D002648:Child; D002710:Chlorhexidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000276:immunology; D004342:Drug Hypersensitivity / Q000209:etiology*; D004417:Dyspnea / Q000139:chemically induced; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D014581:Urticaria / Q000139:chemically induced
C010882:chlorhexidine gluconate; D002710:Chlorhexidine