Decrease in the reaction of DNA repair synthesis in response to nicotinamide or 3-aminobenzamide in ultraviolet irradiated systemic lupus erythematosus lymphocytes.
Systemic lupus erythematosus (SLE) lymphocytes failed to accelerate ultraviolet (UV) induced DNA repair synthesis normally observed following inhibition of poly(adenosine diphosphoribose) polymerization. Without inhibitors of poly(adenosine diphosphoribose) polymerase such as nicotinamide or 3-aminobenzamide, DNA repair synthesis following UV irradiation was found to occur normally in the cells of patients. These data suggest that DNA repair is disturbed under special conditions in the lymphocytes of SLE patients.
Takeuchi
F
F
Otsuka
F
F
Enomoto
T
T
Hanaoka
F
F
Yamada
M
M
Kamatani
N
N
Nakano
K
K
Matsuta
K
K
Tanimoto
K
K
Morita
T
T
D001549:Benzamides / Q000494:pharmacology*; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D006801:Humans; D066298:In Vitro Techniques; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D009536:Niacinamide / Q000494:pharmacology*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D014466:Ultraviolet Rays
D001549:Benzamides; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D009536:Niacinamide; C025160:3-aminobenzamide