Effect of trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidin) cyclohexyl]-benzeneacetamide (U-50,488H), a kappa opioid receptor agonist, on intake of food in food-deprived and non-deprived spontaneously hypertensive and normotensive Wistar-Kyoto rats.
The effect of U-50,488H, a selective kappa opioid receptor agonist on the intake of food in food-deprived and non-deprived spontaneously hypertensive and normotensive Wistar-Kyoto rats was determined. In food deprived Wistar-Kyoto rats, intraperitoneal administration of U-50,488H, produced a bell-shaped curve on the intake of food, consistent with earlier reports in the literature. Thus, at a dose of 0.1 mg/kg there was a significant increase in the intake of food and at 10 mg/kg it caused a decrease in the intake of food, at 2, 4 and 6 hr after the treatment with drug. The amount of food consumed at each dose and the time interval was greater in hypertensive rats than in Wistar-Kyoto rats. Similar effects were produced when the animals were not deprived of food. The basal intake of food in the two strains of rats did not differ. The results indicate a greater sensitivity of spontaneously hypertensive rats to kappa opioid receptor agonists and further the previous observations that compared to Wistar-Kyoto rats, the hypertensive rats have a greater density of central kappa opioid receptors.
Bhargava
H N
HN
Department of Pharmacodynamics, University of Illinois, Chicago 60612.
Ramarao
P
P
Richter
C M
CM
Bieniarz
A A
AA
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D000700:Analgesics; D011759:Pyrrolidines; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer