title: Dibromochloropropane (DBCP) effects on the reproductive function of the adult male rat.
abstract: In order to evaluate the effect of dipromochloropropane (DBCP) on reproductive function, groups of male adult Wistar rats were injected subcutaneously with different doses of DBCP. A strictly dose-dependent effect resulting in histological alteration principally toward the seminiferous tubules was observed. Sperm count and sperm motility showed azoospermia or oligoasthenospermia with a significative recovery in the lower dose of DBCP treated rats. Among the enzymatic activities evaluated as biochemical markers of testicular function: LDH was not appreciably affected by the DBCP treatment while GGT and NADPH-cyt P450-reductase significantly enhanced suggesting an induction of the detoxification processes.
authors.affiliation: Istituto di Clinica Ostetrica e Ginecologica, Università di Genova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Leone
authors.forename: M
authors.initials: M
authors.lastname: Costa
authors.forename: G L
authors.initials: GL
authors.lastname: Capitanio
authors.forename: S
authors.initials: S
authors.lastname: Palmero
authors.forename: M
authors.initials: M
authors.lastname: Prati
authors.forename: M M
authors.initials: MM
authors.lastname: Leone
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004822:Epididymis / Q000187:drug effects; D005298:Fertility / Q000187:drug effects*; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008297:Male; D009251:NADPH-Ferrihemoprotein Reductase / Q000032:analysis; D011407:Propane / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012671:Seminiferous Tubules / Q000187:drug effects; D013076:Sperm Count / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D013739:Testosterone / Q000096:biosynthesis; D005723:gamma-Glutamyltransferase / Q000032:analysis
chemical_list: D013739:Testosterone; C007318:1,2-dibromo-3-chloropropane; D007770:L-Lactate Dehydrogenase; D009251:NADPH-Ferrihemoprotein Reductase; D005723:gamma-Glutamyltransferase; D011407:Propane