title: Absence of significant autosomal lesions in Huntington's disease.
abstract: Peripheral blood from six patients with Huntington's disease (HD) and six controls were cultured in three types of media known to produce fragile sites. A total of 3000 metaphases per group were scrutinized in a blind coded study. No significantly specific 'hot-spot' was found capable of differentiating between HD patients and controls.
authors.forename: G C
authors.initials: GC
authors.lastname: Beverstock
authors.forename: A
authors.initials: A
authors.lastname: Mol
authors.forename: E
authors.initials: E
authors.lastname: Wienhofer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002478:Cells, Cultured; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D003470:Culture Media; D005260:Female; D005467:Floxuridine / Q000494:pharmacology; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic
chemical_list: D003470:Culture Media; D005467:Floxuridine; D001973:Bromodeoxyuridine