Monoclonal gammopathy in chronic myeloproliferative disorders.
The incidence of monoclonal gammopathy in 61 patients with chronic myeloproliferative disorders (CMPD) was studied. The distribution of patients among the CMPD subgroups was: chronic myelocytic leukemia, 24 patients; myelofibrosis, 11; polycythemia vera, 15; essential thrombocythemia, 7; unclassified MPD, 4 patients. Monoclonal gammopathy was found in 5 patients (8.2%). Two of these patients (1 IgA/k and 1 IgM/k) had myelofibrosis and 3 (2 IgG/k and 1 IgG/lambda) polycythemia vera. The presence of monoclonal gammopathy indicates an involvement of the lymphoplasmatic system in CMPD.
Economopoulos
T
T
Second Department of Internal Medicine, Evangelismos Hospital, Athens, Greece.
Economidou
J
J
Papageorgiou
E
E
Dervenoulas
J
J
Christodoulides
C
C
Pappa
V
V
Karakassis
D
D
Terzoglou
C
C
Athanassiadou
S
S
Chalevelakis
G
G
D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000097:blood / Q000150:complications* / Q000473:pathology; D010265:Paraproteinemias / Q000097:blood / Q000209:etiology* / Q000473:pathology; D011446:Prospective Studies