Response of pulmonary mechanics to terbutaline in patients with bronchopulmonary dysplasia.
Terbutaline was administered to eight ventilator-dependent infants with evolving bronchopulmonary dysplasia to determine the potential for reductions in airway resistance. The drug was administered by nebulization through the endotracheal tube. Pre-treatment and post-treatment pulmonary mechanics measurements were performed. Patients had reductions in inspiratory (-14%, p = NS), expiratory (-47%, p less than .05) and total (-24%, p = NS) resistances. Tidal volume increased 36% (p less than .01). This study demonstrates that nebulized terbutaline can improve pulmonary mechanics in ventilator-dependent infants with evolving bronchopulmonary dysplasia.
Brudno
D S
DS
Department of Pediatrics, Medical College of Georgia, Augusta 30912.
Parker
D H
DH
Slaton
G
G
D000403:Airway Resistance / Q000187:drug effects*; D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D013726:Terbutaline / Q000494:pharmacology*; D013990:Tidal Volume
D013726:Terbutaline