[Effect of an antiserum to brain gamma gamma-enolase (protein 14-3-2) on ethanol consumption by rats].
The influence of intracisternal administration of antiserum to the neurospecific brain gamma gamma-enolase (aS-gamma gamma) on the consumption of 7.5% ethanol solution by rats was studied. Injection of aS-gamma gamma decreased the ethanol intake by the rats which had been drinking 15% solution of ethanol for 7 months as a single source of liquid. In vitro aS-gamma gamma caused 4-fold inhibition of the gamma gamma-enolase activity while it did not influence the alpha alpha-enolase activity. Intracisternal administration of aS-gamma gamma shifted enolase isoenzyme spectra in the direction of the decrease of gamma gamma-enolase content. It is suggested that the effect of aS-gamma gamma on ethanol consumption is due to inhibition of the activity of gamma gamma-enolase which participates in energy metabolism in neurons.
Usatenko
M S
MS
Shabanov
P D
PD
Matveeva
I M
IM
Kalishevich
S Iu
SIu
Borodkin
Iu S
IuS
D000428:Alcohol Drinking / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000276:immunology; D002946:Cisterna Magna; D004326:Drinking / Q000187:drug effects; D007106:Immune Sera / Q000008:administration & dosage / Q000494:pharmacology*; D007114:Immunization / Q000379:methods; D010751:Phosphopyruvate Hydratase / Q000032:analysis / Q000276:immunology*; D011817:Rabbits; D051381:Rats
D007106:Immune Sera; D010751:Phosphopyruvate Hydratase
Vliianie antisyvorotki k gamma gamma-enolaze mozga (belku l4-3-2) na potreblenie étanola krysami.