Activation in vivo of a major antisuppressor T-cell pathway immediately after immunization. III. T-cell requirements for its induction.
Immunogenic stimuli rapidly induce a potent mediator with antisuppressor activity which represents complexes of Ig and antigen. The formation of the complexes depends on the interaction of two T cells both of which bear the Ly1 phenotype. The two T cells can be separated on the basis of their sensitivity to antilymphocytic serum and dependency on the presence of thymus. T cells bearing I region coded determinants are essential for the formation of the mediator.
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D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis / Q000528:radiation effects; D007108:Immune Tolerance / Q000528:radiation effects; D007074:Immunoglobulin G / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000528:radiation effects; D051379:Mice; D008807:Mice, Inbred BALB C; D010641:Phenotype; D013491:Suppressor Factors, Immunologic / Q000096:biosynthesis; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology* / Q000378:metabolism; D013997:Time Factors
D001798:Blood Proteins; D007074:Immunoglobulin G; D013491:Suppressor Factors, Immunologic; C011850:immunoenhancing factor