title: Intravascular mixing and drug distribution: the concurrent disposition of thiopental and indocyanine green.
abstract: The dispositions of concomitantly administered indocyanine green (ICG) and thiopental were determined in 12 patients undergoing general anesthesia and surgery. These were best characterized by a two-compartment ICG model and a four-compartment thiopental model, chiefly because of data obtained from frequent early arterial blood samples. The models had a common central volume (V1), and the peripheral ICG compartment was the subset of a peripheral thiopental compartment. The two-compartment ICG model described its mixing within the intravascular space. The traditional VC of three-compartment models of thiopental disposition is described by the present four-compartment model as an initial distribution volume, V1, codetermined by ICG as central blood volume, and a rapidly equilibrating peripheral volume, V4. The combined simultaneous ICG-thiopental model more clearly reflects physiology than do the results of earlier curve-fitting techniques and may be useful in studying the pharmacokinetic basis of altered reactivity to thiopental.
authors.affiliation: Department of Anesthesia, Northwestern University School of Medicine, Chicago, IL 60611.
authors.forename: T K
authors.initials: TK
authors.lastname: Henthorn
authors.forename: M J
authors.initials: MJ
authors.lastname: Avram
authors.forename: T C
authors.initials: TC
authors.lastname: Krejcie
mesh_terms: D000328:Adult; D004058:Diffusion; D004338:Drug Combinations; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D013874:Thiopental / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D004338:Drug Combinations; D007208:Indocyanine Green; D013874:Thiopental