The effect of isoprenaline on the phospholipid content of the compact and spongious musculature of the carp ventricular myocardium.
1. After a single injection of 40 mg kg-1 of isoprenaline to the carp, lysophospholipids appear in the tissue of the heart ventricle, ethanolamine plasmalogens increase and choline plasmalogens decrease; phosphatidylinositol is lowered in the spongious layer only. 2. Daily administration of 5 mg kg-1 of the drug leads, after 5 doses, to a dramatic decrease of the diphosphatidylglycerol content; during the subsequent 5 and 10 doses a return to normal values occurs. Shifts in plasmalogens are similar to those found after a single high dose. Some other phospholipids change significantly. 3. All changes reveal that the spongious musculature is more sensitive to the drug than the compact one.
Drnková
J
J
Department of Animal Physiology and Developmental Biology, Faculty of Natural Sciences, Charles University, Vinicná, Czechoslovakia.
Nováková
O
O
Pelouch
V
V
Ostádal
B
B
Kubista
V
V
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002347:Carps / Q000378:metabolism*; D003530:Cyprinidae / Q000378:metabolism*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D010955:Plasmalogens / Q000494:pharmacology
D010743:Phospholipids; D010955:Plasmalogens; C032459:choline plasmalogens; D007545:Isoproterenol