Intestinal absorption of cephalosporin antibiotics: correlation between intestinal absorption and brush-border membrane transport.
The absorption of seven cephalosporin antibiotics from the in-situ intestinal loop at pH 7.4 and their transport by brush-border membrane vesicles in the presence of an inward H+ gradient ([pH]i = 7.5, [pH]o = 6.0) were examined. A good correlation was found between the intestinal absorption rate and the initial uptake rate by brush-border membrane vesicles. The data suggest that the transport study using intestinal brush-border membrane vesicles is useful as a model system for the intestinal absorption of beta-lactam antibiotics.
Hori
R
R
Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Japan.
Okano
T
T
Kato
M
M
Maegawa
H
H
Inui
K
K
D000818:Animals; D002511:Cephalosporins / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D008297:Male; D008871:Microvilli / Q000378:metabolism*; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains
D002511:Cephalosporins