Dental and metabolic effects of lactitol in the diet of laboratory rats.
1. Because so little is known about the properties of lactitol as a possible alternative bulk sweetener to sucrose, it was tested in two large-scale experiments in laboratory rats. Matched groups of caries-active Osborne-Mendel rats were fed on uniform diets containing lactitol and compared with a sucrose control in both experiments, plus a xylitol control in the first experiment. 2. In the early stages of the experiments weight gains and food utilization were better on the sucrose than on the lactitol regimens. Body-fat storage was higher on the sucrose than on the polyol regimens. 3. At the end of 8 weeks the mandibular molars were examined for dental plaque accumulation and dental caries. The dental caries scores when 160 g sucrose/kg in the diet was replaced by lactitol were lower by a highly significant margin, bringing them down to the same low level as those on a 160 g xylitol/kg regimen. 4. Testing lactitol in a manufactured food product, shortbread biscuits, in comparison with ordinary sucrose biscuits, showed differences in plaque scores (significant) and caries levels (highly significant), with 60% fewer lesions on the lactitol regimen. 5. The results confirm the low cariogenic potential of lactitol, but show metabolic differences compared with sucrose.
Grenby
T H
TH
Department of Oral Medicine and Pathology, United Medical and Dental School, Guy's Hospital, London.
Phillips
A
A
D000818:Animals; D003731:Dental Caries / Q000139:chemically induced*; D003773:Dental Plaque / Q000139:chemically induced*; D004037:Diet, Cariogenic; D002149:Energy Intake; D004734:Energy Metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013395:Sucrose / Q000378:metabolism; D013402:Sugar Alcohols / Q000378:metabolism*; D014867:Water / Q000378:metabolism; D015430:Weight Gain; D014993:Xylitol / Q000378:metabolism
D013402:Sugar Alcohols; D014867:Water; D013395:Sucrose; C014635:lactitol; D014993:Xylitol