Effects of caerulein + haloperidol on amphetamine-induced locomotor stereotypy in rats.
The combination of haloperidol + caerulein has been reported to produce a long-lasting reduction of amphetamine-induced hyperlocomotions in rats. This study was designed to replicate those findings and to determine whether haloperidol + caerulein produce any unique effect on amphetamine-induced locomotor stereotypy. In two experiments, haloperidol + caerulein failed to produce a long-lasting reduction in amphetamine-induced hyperlocomotions. Although haloperidol reduced the locomotor stereotypy produced by higher doses of amphetamine, caerulein had no effect, either alone or combined with haloperidol.
Mueller
K
K
Department of Psychology, Texas Christian University, Fort Worth 76129.
Peel
J L
JL
Rewey
K L
KL
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D002108:Ceruletide / Q000494:pharmacology*; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*
D002108:Ceruletide; D000661:Amphetamine; D006220:Haloperidol