Incidence of aerobactin-positive Escherichia coli strains in patients with symptomatic urinary tract infection.
A total of 323 Escherichia coli strains from children with primary acute non-obstructive pyelonephritis (n = 144) or cystitis (n = 56) and from adults with acute non-obstructive pyelonephritis (n = 66) or cystitis (n = 57) were examined for presence of the aerobactin-mediated iron uptake system and expression of P-fimbriae. Overall, pyelonephritogenic Escherichia coli strains were significantly more often aerobactin-positive (72%) than cystitis strains (42%) (p less than 0.001). Seventy-three percent of the isolates from children with acute pyelonephritis were aerobactin-positive compared to 54% of the cystitis strains (p less than 0.05). Pyelonephritogenic Escherichia coli strains from adults were also significantly more often aerobactin-positive (70%) than cystitis strains (30%) (p less than 0.001). The cystitis strains from children were more often aerobactin-positive than cystitis strains from adult patients (p less than 0.05). There was a significant correlation between presence of the aerobactin-mediated iron uptake system and expression of P-fimbriae in all strains (p less than 0.001).
Jacobson
S H
SH
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Hammarlind
M
M
Lidefeldt
K J
KJ
Osterberg
E
E
Tullus
K
K
Brauner
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003556:Cystitis / Q000382:microbiology; D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism* / Q000648:ultrastructure; D004927:Escherichia coli Infections / Q000382:microbiology*; D005260:Female; D010861:Fimbriae, Bacterial / Q000648:ultrastructure; D006801:Humans; D006877:Hydroxamic Acids / Q000096:biosynthesis*; D007501:Iron / Q000378:metabolism; D007502:Iron Chelating Agents / Q000378:metabolism*; D008875:Middle Aged; D011704:Pyelonephritis / Q000382:microbiology; D014552:Urinary Tract Infections / Q000382:microbiology*
D006877:Hydroxamic Acids; D007502:Iron Chelating Agents; C031819:aerobactin; D007501:Iron