title: Kinetics of the MLR response following single donor-specific allogeneic blood transfusions.
abstract: Prior blood transfusion (BT) confers a significant improvement in transplant survival in recipients (1). However, increased survival across major histocompatibility barriers generally requires the administration of immunosuppressive agents (2-5). The mechanisms by which BT prolongs graft survival have not been fully elucidated. Experimental evidence suggests that suppressor cells (6,7), soluble suppressor factors (8), and blocking antibodies (9) may play a role.
authors.forename: B A
authors.initials: BA
authors.lastname: Fox
authors.forename: P W
authors.initials: PW
authors.lastname: Westrick
authors.forename: S D
authors.initials: SD
authors.lastname: Nathanson
mesh_terms: D000818:Animals; D001803:Blood Transfusion; D005260:Female; D007156:Immunologic Memory; D007700:Kinetics; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D013154:Spleen / Q000276:immunology