title: Results of percutaneous mitral commissurotomy in 200 patients.
abstract: To assess the feasibility and efficacy of percutaneous mitral commissurotomy (PMC), the procedure was attempted in 200 patients with severe mitral stenosis. There were 154 women and 46 men, their mean age was 43 +/- 16 years (range 13 to 79) and 15 were older than 70 years of age. Forty-four had had previous surgical commissurotomy. Forty were in New York Heart Association class II, 152 in class III and 8 in class IV. In regard to valvular anatomy, 67 had calcified valves, 58 had pliable valves and only mild subvalvular disease, and 75 had flexible valves but extensive subvalvular disease. Grade 1+ mitral regurgitation was present in 62 and grade 2+ in 2. In 11 patients the procedure was discontinued because of complications in 3 and technical failure in 8. Six of the 8 technical failures occurred during the first 15 attempts. Effective PMC was performed in 189 patients using 1 balloon in 23 and 2 balloons in 166. After PMC, there was a significant improvement in mean left atrial pressure (21 +/- 7 to 12 +/- 5 mm Hg, p less than 0.0001), mean mitral gradient (16 +/- 6 to 6 +/- 2 mm Hg, p less than 0.0001), cardiac index (2.6 +/- 0.8 to 3.1 +/- 0.8 liters/min/m2, p less than 0.001) and valve area assessed by hemodynamics (1.1 +/- 0.3 to 2.2 +/- 0.5 cm2, p less than 0.0001) and 2-dimensional echocardiography (1 +/- 0.3 to 1.9 +/- 0.4 cm2, p less than 0.0001). No patient died. Embolism occurred in 8 (4%), with no further sequelae. Sixteen (8%) had atrial septal defect detected by oxymetry.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Cardiology, Hôpital Tenon, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Vahanian
authors.forename: P L
authors.initials: PL
authors.lastname: Michel
authors.forename: B
authors.initials: B
authors.lastname: Cormier
authors.forename: B
authors.initials: B
authors.lastname: Vitoux
authors.forename: X
authors.initials: X
authors.lastname: Michel
authors.forename: M
authors.initials: M
authors.lastname: Slama
authors.forename: L E
authors.initials: LE
authors.lastname: Sarano
authors.forename: S
authors.initials: S
authors.lastname: Trabelsi
authors.forename: M
authors.initials: M
authors.lastname: Ben Ismail
authors.forename: J
authors.initials: J
authors.lastname: Acar
mesh_terms: D000328:Adult; D002404:Catheterization / Q000009:adverse effects / Q000379:methods; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D008946:Mitral Valve Stenosis / Q000503:physiopathology / Q000601:surgery*