title: Cytogenetic and molecular studies of the Philadelphia translocation t(9;22) observed in a patient with myelodysplastic syndrome.
abstract: We report here the case of a patient with refractory anemia with excess of blasts (RAEB) which evolved into RAEB in transformation. The standard Philadelphia (Ph) chromosome was found by cytogenetic study at diagnosis and during evolution. Southern blot analysis showed breakpoint cluster region (bcr) rearrangement as observed in chronic myelogenous leukemia (CML).
authors.affiliation: Service de Médecine Interne, Oncologie, Hôpital Saint-Antoine, Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Smadja
authors.forename: M
authors.initials: M
authors.lastname: Krulik
authors.forename: A
authors.initials: A
authors.lastname: Hagemeijer
authors.forename: D C
authors.initials: DC
authors.lastname: van der Plas
authors.forename: G
authors.initials: G
authors.lastname: Gonzalez Canali
authors.forename: A
authors.initials: A
authors.lastname: de Gramont
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics; D008297:Male; D010677:Philadelphia Chromosome