Suppressive effect of macrophages on interferon-gamma production by human peripheral lymphocytes stimulated with Mycoplasma pneumoniae.
Production of interferon (IFN)-gamma was investigated in human peripheral lymphocytes stimulated with Mycoplasma pneumoniae. Lymphocytes obtained from non-immune individuals produced no IFN. IFN-gamma was produced by T cells obtained from immune individuals, and the helper/inducer T cells produced two- to sixfold higher titer of IFN-gamma than the suppressor/cytotoxic T cells. The addition of macrophages in T cell cultures suppressed the production of IFN-gamma; this differs from the previous result wherein the addition of macrophages enhanced the production of IFN-gamma, when stimulated with mumps virus or measles virus.
Nakayama
T
T
Department of Pediatrics, School of Medicine, Keio University, Tokyo.
Urano
T
T
Osano
M
M
Maehara
N
N
Sasaki
K
K
Hayatsu
E
E
Makino
S
S
D000328:Adult; D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D002648:Child; D006801:Humans; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000096:biosynthesis*; D008264:Macrophages / Q000276:immunology*; D008459:Measles virus / Q000276:immunology; D009109:Mumps virus / Q000276:immunology; D009177:Mycoplasma pneumoniae / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D007371:Interferon-gamma