Echocardiographic and histologic evaluation of the right ventricle in ventricular tachycardias of left bundle branch block morphology without overt cardiac abnormality.
The right ventricle was investigated by multiple biopsies and detailed echocardiographic evaluation, including measurement of cavity dimensions at the level of the inflow, body and outflow tract, in 27 patients with right ventricular tachycardia who had no clinical evidence of an underlying morphologic abnormality. Nine (33%) patients had abnormal biopsy results, with a quantifiable increase in interstitial fibrosis. Abnormal echocardiograms, defined as an increase in greater than or equal to 2 dimensions of the right ventricular cavity or wall motion abnormalities or both, were seen in 9 patients. There was a strong association between abnormal myocardial histologies and abnormal right ventricular echocardiograms (p less than 0.001). An abnormal echocardiogram was 94% specific and 80% sensitive for an abnormal biopsy. The findings of echocardiography and biopsy were correlated with the electrocardiographic features of the tachycardia. Evidence of right ventricular disease was seen in all 6 patients with superior frontal plane axis of clinical tachycardia as compared with 4 of 21 with inferior axis (p less than 0.001). Thus, 2-dimensional echocardiography is a sensitive means of diagnosing right ventricular disease in patients with nonischemic tachycardias of left bundle branch block morphology. A superior frontal plane axis of ventricular tachycardia in this group strongly suggests right ventricular disease, whereas an inferior frontal plane axis is frequently not associated with any morphologic or histologic abnormality of the right ventricle.
Mehta
D
D
Department of Cardiological Sciences, St. George's Hospital Medical School, London, United Kingdom.
Odawara
H
H
Ward
D E
DE
McKenna
W J
WJ
Davies
M J
MJ
Camm
A J
AJ
D000328:Adult; D002037:Bundle-Branch Block / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D013318:Stroke Volume; D013610:Tachycardia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*