Effect of H2 antagonists cimetidine and famotidine on the hemotoxicity of cyclophosphamide.
A comparison between the effects of H2 antagonists Cimetidine and Famotidine on the hemotoxicity of Cyclophosphamide in vivo in DBA/2NCrBl mice is described. Hemotoxicity of anticancer drug was determined by peripheral blood leukocytes, bone marrow cells and bone marrow CFU-S, GM-CFC. Results show that Famotidine does not increase Cyclophosphamide hemotoxicity while Cimetidine enhances the toxicity of the anticancer drug only on normal pluripotent hemopoietic stem cells.
Lerza
R A
RA
Patologia Speciale Medica B, University of Genoa, Italy.
Bogliolo
G V
GV
Mencoboni
M P
MP
Saviane
A G
AG
Pannacciulli
I M
IM
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D002927:Cimetidine / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000633:toxicity*; D015738:Famotidine; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000473:pathology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D007958:Leukocyte Count / Q000187:drug effects*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D012016:Reference Values; D013844:Thiazoles / Q000494:pharmacology*
D006635:Histamine H2 Antagonists; D013844:Thiazoles; D015738:Famotidine; D002927:Cimetidine; D003520:Cyclophosphamide