Viable intraluminal tumour cells and local/regional tumour growth in experimental colon cancer.
To determine if viable intraluminal tumour cells can leak through a watertight anastomosis and cause local/regional (extraluminal) tumour growth, tumour cells were introduced 2 cm proximal to a colonic anastomosis following laparotomy in a Wistar/Furth rat colon cancer model. Local/regional tumour growth was observed in all rats except a sham anastomotic group. No intraluminal tumour growth was observed in either group. Viable intraluminal tumour cells cause local/regional tumour growth by leakage through a clinically intact anastomosis and may be an important cause of local/regional tumour growth in human colorectal cancer.
O'Dwyer
P J
PJ
Ohio State University College of Medicine, Columbus.
Martin
E W
EW
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D003106:Colon / Q000601:surgery*; D003110:Colonic Neoplasms / Q000473:pathology*; D019476:Insect Proteins; D008297:Male; D009366:Neoplasm Seeding; D011392:Proline; D011506:Proteins; D051381:Rats; D047011:Silk; D013537:Sutures
D019476:Insect Proteins; D011506:Proteins; D047011:Silk; D011392:Proline