title: O-dephenylation and conjugation with benzoylornithine. New metabolic pathways for 3-phenoxybenzoic acid in chickens.
abstract: Metabolism of [benzyl-14C]fluvalinate by chickens produces 3-phenoxybenzoic acid, which is further degraded by two new pathways. The first pathway involves O-dephenylation, not reported previously for related pyrethroids in birds or mammals. O-Dephenylation is a major metabolic route (12% of the applied 14C). In the second pathway, 2% of the applied dose is converted into four conjugates of benzoylornithine (two with 3-hydroxybenzoic and two with 3-phenoxybenzoic acids). The predominant conjugate with benzoylornithine is N2-(3-hydroxybenzoyl)-N5-benzoylornithine.
authors.affiliation: Sandoz Crop Protection Corporation, Zoecon Research Institute, Palo Alto, CA 94303-0859.
authors.forename: G B
authors.initials: GB
authors.lastname: Quistad
authors.forename: A L
authors.initials: AL
authors.lastname: Saunders
authors.forename: W S
authors.initials: WS
authors.lastname: Skinner
authors.forename: K D
authors.initials: KD
authors.lastname: Collier
authors.forename: D H
authors.initials: DH
authors.lastname: Sakai
authors.forename: C C
authors.initials: CC
authors.lastname: Reuter
mesh_terms: D000818:Animals; D001565:Benzoates / Q000378:metabolism*; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D002645:Chickens; D002853:Chromatography, Liquid; D005243:Feces / Q000032:analysis; D005260:Female; D007668:Kidney / Q000378:metabolism; D009952:Ornithine / Q000031:analogs & derivatives* / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001565:Benzoates; C017618:3-phenoxybenzoic acid; D009952:Ornithine