Effect of testosterone on the kinetics of the development of suppressor cells in adjuvant arthritis.
The induction of unresponsiveness to mycobacterial adjuvant took a longer time in male DA rats than in female rats. A shift in the induction time of unresponsiveness in males toward the female type was brought about by castration, but could be reverted to the male type by the application of testosterone. The transfer study revealed that cells capable of preventing arthritis required a longer incubation time for their development in males than in females. This suggests that testosterone inhibits the development of suppressor cells in adjuvant arthritis.
Tsukano
M
M
Kotani
M
M
Matsuno
K
K
Miyakawa
K
K
Nawa
Y
Y
D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000276:immunology*; D005260:Female; D008297:Male; D009159:Mycobacteriaceae; D051381:Rats; D011919:Rats, Inbred Strains; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology*; D013997:Time Factors
D013739:Testosterone