title: Grades of nodular sclerosis (NSI-NSII) in Hodgkin's disease. Are they of independent prognostic value?
abstract: Subclassification of the nodular sclerosis (NS) type of Hodgkin's disease in Grade 1 and 2 was reported for the first time by the British National Lymphoma Investigation (BNLI). Three groups, the BNLI, Gärtner et al. and the current authors, found clearly different survival rates between Grade 1 and 2 NS patients. The authors studied retrospectively if this NS grading has an independent prognostic value in 90 NS patients, diagnosed in ten hospitals in the southeastern part of the Netherlands (1972-1983). In this study there is no significant difference in sex, age, B-symptoms, erythrocyte sedimentation rate (ESR), stage, positive laparotomy, involvement of mediastinum or spleen, lymphocyte count, and percentage of complete remissions between the NS subgroups. Multivariate analysis suggests that the subclassification of NS in Grades 1 and 2 is a prognostic factor in survival independent of age, stage and ESR. This finding and the high relative frequency of NS makes application of this NS subdivision probably clinically useful to identify patients for a risk-adapted therapy.
authors.affiliation: Integraal Kankercentrum Zuid, Sooz, Tilburg, Eindhoven, The Netherlands.
authors.forename: T J
authors.initials: TJ
authors.lastname: Wijlhuizen
authors.forename: L W
authors.initials: LW
authors.lastname: Vrints
authors.forename: R
authors.initials: R
authors.lastname: Jairam
authors.forename: W P
authors.initials: WP
authors.lastname: Breed
authors.forename: J T
authors.initials: JT
authors.lastname: Wijnen
authors.forename: L J
authors.initials: LJ
authors.lastname: Bosch
authors.forename: M A
authors.initials: MA
authors.lastname: Crommelin
authors.forename: F E
authors.initials: FE
authors.lastname: van Dam
authors.forename: J
authors.initials: J
authors.lastname: de Koning
authors.forename: M
authors.initials: M
authors.lastname: Verhagen-Teulings
mesh_terms: D000328:Adult; D001799:Blood Sedimentation; D005260:Female; D006689:Hodgkin Disease / Q000097:blood / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012598:Sclerosis / Q000473:pathology