Serum and urine glycosaminoglycans in myeloid leukemia and myelodysplasia.
Urinary glycosaminoglycan excretion is increased in a variety of human diseases, including malignancy. We have measured serum and urine glycosaminoglycan levels by the carbazole method of uronic acid determination in patients with myeloid leukemia or myelodysplasia. Eleven patients were studied during active disease as well as eight in complete remission. Serum levels in patients with active disease did not differ significantly from 11 healthy volunteers with no hematological disease. In contrast, the median urine level for the patients with active disease was 7.6 mg uronate/g Creatinine (Creat) compared to 2.6 for controls (p less than 0.002). Interestingly, the eight patients in complete remission also had a significant increase in uronate excretion with a median of 7.3 (p less than 0.002). These results suggest that elevated urinary glycosaminoglycan levels in leukemia are not due to impaired ability of the liver to clear circulating glycosaminoglycans or overproduction by leukemic cells. The observed increase in glycosaminoglycan excretion may be due to altered bone marrow matrix metabolism that is often not reversed by the achievement of hematologic remission.
Luikart
S D
SD
Department of Medicine, University of Minnesota Medical School, Minneapolis.
Fosdick
L
L
Ogle
K M
KM
Peterson
B A
BA
Bloomfield
C D
CD
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006025:Glycosaminoglycans / Q000097:blood* / Q000652:urine; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood* / Q000188:drug therapy / Q000652:urine; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood* / Q000188:drug therapy / Q000652:urine; D012074:Remission Induction; D014574:Uronic Acids / Q000097:blood / Q000652:urine
D006025:Glycosaminoglycans; D014574:Uronic Acids