title: Use of sodium iodide to overcome the eluate age restriction for Ceretec reconstitution.
abstract: The Ceretec kit for preparation of 99Tcm-hexamethylpropyleneamine oxime (HMPAO) complex for the investigation of regional cerebral blood flow requires careful handling by the radiopharmacist and a number of restrictions have been placed on the kit relating to the nature of 99Tcm generator eluate used for reconstitution. The addition of sodium iodide to eluate immediately after elution can remove one of these restrictions. A level of 0.4 mg sodium iodide added after elution allows reconstitution of Ceretec up to 6 h later with no adverse effect on radiochemical purity. This offers a simple method for the use of this product if availability of fresh technetium generator eluate is a constraint.
authors.affiliation: Pharmaceuticals Research and Development, Amersham International plc, Buckinghamshire, UK.
authors.forename: V J
authors.initials: VJ
authors.lastname: Bayne
authors.forename: A M
authors.initials: AM
authors.lastname: Forster
authors.forename: D A
authors.initials: DA
authors.lastname: Tyrrell
mesh_terms: D006863:Hydrogen-Ion Concentration; D007454:Iodides; D009584:Nitrogen; D009942:Organometallic Compounds; D010084:Oxidation-Reduction; D010091:Oximes; D012974:Sodium Iodide; D013667:Technetium; D019690:Technetium Tc 99m Exametazime; D013997:Time Factors
chemical_list: D007454:Iodides; D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D013667:Technetium; D012974:Sodium Iodide; D009584:Nitrogen