Red blood cell fatty acids in multiple sclerosis.
The fatty acid (FA) composition of each phospholipid constituent of the red blood cells (RBC) was analyzed, by thin-layer and gas chromatography techniques, in 61 multiple sclerosis (MS) patients and 61 normal subjects, in whom the plasma lipid FA composition had previously been studied. The MS patients showed a significant decrease in the proportions of linoleic and arachidonic acids in most phospholipids, with a compensatory increase of saturated FA. Correlations between FA percentages in plasma and cell lipids demonstrated abnormalities in the MS patients, suggestive of a disturbance in the exchange between these compartments. The alterations reported in plasma and RBC in the MS patients are consistent with a relative deficiency of essential FA.
Navarro
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Department of Physiology, Autonomous University of Barcelona, Spain.
Segura
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D001095:Arachidonic Acids / Q000097:blood; D004912:Erythrocytes / Q000032:analysis*; D005227:Fatty Acids / Q000097:blood*; D006801:Humans; D008041:Linoleic Acids / Q000097:blood; D009103:Multiple Sclerosis / Q000097:blood*; D010743:Phospholipids / Q000097:blood; D010949:Plasma / Q000032:analysis
D001095:Arachidonic Acids; D005227:Fatty Acids; D008041:Linoleic Acids; D010743:Phospholipids