Kynurenic acid and AP5 distinguish between NMDA receptor agonists.
Quantitative analysis of responses to amino acids in mouse cortical slices has indicated that the antagonists kynurenate and 2-amino-5-phosphonopentanoic acid distinguish between ibotenate and both N-methyl-D-aspartate (NMDA) and quinolinate. This result is consistent with the existence of NMDA-receptor subtypes.
Williams
T L
TL
Department of Physiology, St. George's Hospital Medical School, London, United Kingdom.
Stone
T W
TW
Burton
N R
NR
Smith
D A
DA
D015763:2-Amino-5-phosphonovalerate; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007051:Ibotenic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007736:Kynurenic Acid / Q000378:metabolism* / Q000494:pharmacology; D051379:Mice; D016202:N-Methylaspartate; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000037:antagonists & inhibitors / Q000494:pharmacology; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D014633:Valine / Q000031:analogs & derivatives* / Q000494:pharmacology
D011805:Quinolinic Acids; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D007051:Ibotenic Acid; D001224:Aspartic Acid; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; D017378:Quinolinic Acid; D007736:Kynurenic Acid; D014633:Valine