Goitrogenic effects in offspring of swine fed sulfadimethoxine and ormetoprim in late gestation.
Effects of feeding sulfadimethoxine and ormetoprim to sows and gilts in late gestation were evaluated. One sow and 2 gilts were randomly selected and were fed 1 of 3 rations: (1) a gestation ration from farm A, where congenital goiter in newborn pigs was a problem, (2) gestation ration from farm A containing 275 g of sulfadimethoxine and 55 g of ormetoprim/100 kg of ration, or (3) standard swine gestation ration containing 275 g of sulfadimethoxine and 55 g of ormetoprim/100 kg of ration. Sows and gilts were fed the appropriate ration for 22 to 58 days before farrowing. The numbers of stillborn or weak pigs did not increase in any group. However, congenital goiter was detected in all pigs from swine fed medicated rations 2 and 3. Congenital goiter was not present in pigs from swine given gestation ration 1.
Blackwell
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TE
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108.
Werdin
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RE
Eisenmenger
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MC
FitzSimmons
M A
MA
D000821:Animal Feed; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005313:Fetal Death / Q000139:chemically induced / Q000662:veterinary; D006042:Goiter / Q000139:chemically induced / Q000151:congenital / Q000473:pathology / Q000662:veterinary*; D011247:Pregnancy; D011743:Pyrimidines / Q000009:adverse effects*; D013412:Sulfadimethoxine / Q000009:adverse effects*; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced* / Q000151:congenital / Q000473:pathology; D013974:Thyroxine / Q000097:blood
D011743:Pyrimidines; D013412:Sulfadimethoxine; C100125:ormetoprim; D013974:Thyroxine