[Influence of endogenous catecholamines on responses of rat lung to beta-adrenergic agonists].
Relaxation responses to the beta-adrenoceptor agonists: isoprenaline (non selective), salbutamol (beta 2-selective) and noradrenaline (plus phentolamine 10(-5) M) (beta 1-selective) have been obtained on rat lung parenchymal strips in the absence and presence of pargyline and tropolone (monoamino-oxidase and catechol-O-methyltransferase inhibitors), cocaine (neuronal uptake blocking agent), corticosterone (extraneuronal uptake inhibitor) as well as in reserpinized rat. Responses to these beta-adrenergic agonists were not potentiated in the presence of any of these inhibitors. This indicates that endogenous catecholamines, enzymatic or uptake processes, do not modulate beta-adrenoceptor mediated responses of rat lung strip and demonstrates that there is no correlation between neuronal uptake/beta 1-adrenoceptors and extraneuronal uptake/beta 2-adrenoceptor mediated responses, as had previously been suggested.
Candenas
M L
ML
Departamento de Farmacología y Farmacotecnia (Farmacognosia y Farmacodinamia) Facultad de Farmacia, Valencia, España.
Anselmi
E
E
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D002395:Catecholamines / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D007545:Isoproterenol / Q000494:pharmacology; D008168:Lung / Q000187:drug effects*; D008297:Male; D009638:Norepinephrine / Q000502:physiology; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D014334:Tropolone / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D002395:Catecholamines; D014334:Tropolone; D012110:Reserpine; D010293:Pargyline; D007545:Isoproterenol; D000420:Albuterol; D009638:Norepinephrine
Influencia de catecolaminas endógenas en las respuestas del pulmón de rata a agonistas beta-adrenérgicos.