title: Secretion of liver lipase activity by periportal and perivenous hepatocytes.
abstract: Periportal and perivenous hepatocytes were separated by isopycnic centrifugation through Percoll, or selectively isolated by combined digitonin/collagenase perfusion. With either method, secretion of liver lipase activity was 2-2.5-fold higher in periportal than perivenous cells. This acinar heterogeneity parallels that of cholesterol de novo synthesis and bile formation reported previously.
authors.affiliation: Erasmus University Rotterdam, Department of Biochemistry, The Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: Verhoeven
authors.forename: H
authors.initials: H
authors.lastname: Jansen
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D002469:Cell Separation; D002500:Centrifugation, Isopycnic; D002784:Cholesterol / Q000096:biosynthesis; D008049:Lipase / Q000378:metabolism*; D008099:Liver / Q000166:cytology / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002784:Cholesterol; D008049:Lipase