[An autopsied case of idiopathic interstitial pneumonia, showing a remarkably elevated serum level of CA 19-9].
Discussed herein is an autopsied case of a 30-year-old male with Idiopathic Interstitial Pneumonia (IIP) manifesting a markedly elevated CA 19-9 in the serum (maximum, over 120,000 U/ml). Despite a careful examination, no malignant lesion was found. The postmortem examination revealed a marked elevation of CA 19-9 in the serum and in the lung tissue. Further immunohistochemically regenerative bronchiolar and alveolar epithelial cells were more intensely positive for CA 19-9 than in our controls. These CA 19-9 positive cells for the most part, were found to stain with alcian blue. It is considered that IIP induces activation of sialyl-transferase in these cells.
Okino
T
T
Dept. of Pathology, Kagawa Med. School.
Yamadori
I
I
Ogino
T
T
Miki
H
H
Hirakawa
E
E
Morikawa
T
T
Kobayashi
S
S
Ohmori
M
M
Bungo
M
M
Yamaji
Y
Y
D000328:Adult; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D006801:Humans; D008168:Lung / Q000276:immunology / Q000473:pathology*; D008297:Male; D011658:Pulmonary Fibrosis / Q000276:immunology* / Q000473:pathology
D015295:Antigens, Tumor-Associated, Carbohydrate