Regional calcium accumulation and kainic acid (KA)-induced limbic seizure status in rats.
The sites of calcium accumulation were studied by 45Ca autoradiography during kainic acid (KA)-induced limbic seizure in rats. Two hours after KA injection into unilateral amygdala, calcium accumulated in CA3 of the hippocampus, lateral septal nucleus and thalamic reticular nucleus on KA-injected side. Those sites coincided with the sites where neuronal cell damage appeared 4 h after KA injection. These results suggested that regional calcium accumulation might be responsible for neuronal cell loss induced by seizures.
Tanaka
S
S
Department of Neurosurgery, Asahikawa Medical College, Japan.
Sako
K
K
Tanaka
T
T
Yonemasu
Y
Y
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism*; D007608:Kainic Acid; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
D007608:Kainic Acid; D002118:Calcium