title: [Study of immunologic parameters in parenteral drug addicts (PDA) with condylomata acuminata].
abstract: A study is made of the state of cell and humoral immunity in parenteral drug addicts both with and without genital warts. The results reveal alterations in the lymphocyte subpopulations, with a decrease in the T-helper/T-suppressor (T4+/T8+) ratio of both groups of patients. These alterations were more pronounced in those patients with genital warts (p less than 0.05). The alterations in humoral immunity, expressed as a hypergammaglobulinemia IgG and IgM, were similar in both groups. None of the immunological parameters were affected by the extension of the lesions, though the T4+/T8+ ratio was found to decrease with increasing length evolution of the lesions. It would be convenient to perform longitudinal studies of these preliminary data to evaluate the effect of human papilloma virus (HPV) on the immune system.
authors.affiliation: Departamento de Dermatología, Facultad de Medicina, Hospital Clínico Universitario, Valencia.
authors.forename: M C
authors.initials: MC
authors.lastname: Marzo Lopez
authors.forename: E
authors.initials: E
authors.lastname: Aguilar Ligorit
authors.forename: A
authors.initials: A
authors.lastname: Ramirez Bosca
authors.forename: S
authors.initials: S
authors.lastname: Montolio Doñate
authors.forename: P
authors.initials: P
authors.lastname: Soto Ferrando
authors.forename: A
authors.initials: A
authors.lastname: Castells Rodellas
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003218:Condylomata Acuminata / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D019966:Substance-Related Disorders / Q000150:complications / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M
vernacular_title: Estudio de parámetros inmulógicos en adictos a drogas por vía parenteral (ADVP) con condilomas acuminados.