title: Influence of milk and food on fluoride bioavailability from NaF and Na2FPO3 in man.
abstract: Aqueous solutions of NaF and sodium monofluorophosphate (MFP) were given to fasting young adults in an intra-individual cross-over study. Plasma fluoride (F) levels were measured by use of a F-ion-sensitive electrode, and eight-hour profiles of F concentrations in plasma were determined. F availability and pharmacokinetic data were identical for both substances. Furthermore, the same subjects were given tablets containing 2 mg F, either as NaF or as MFP, under different experimental regimens: (a) on a fasting stomach, (b) together with milk, or (c) together with breakfast and milk. Equal F availabilities were observed for both substances. Plasma peak levels were reduced when the tablets were taken together with food. Intake of milk reduced F availability by 30% compared with the fasting stomach experiment; this effect was abolished when milk was taken as part of the breakfast. It is suggested that formation of Ca salts and entrapment of F in coagulation products of milk are important factors causing reduction of F availability, and that prolonged stay of the chyme after concomitant ingestion of food allows F to become liberated from bound forms and coagulation products by digestion processes.
authors.affiliation: Dental School, University of Würzburg, Federal Republic of Germany.
authors.forename: K
authors.initials: K
authors.lastname: Trautner
authors.forename: J
authors.initials: J
authors.lastname: Einwag
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001682:Biological Availability; D002118:Calcium / Q000378:metabolism; D005260:Female; D005459:Fluorides / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics*; D005502:Food; D006801:Humans; D008297:Male; D008892:Milk / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D012969:Sodium Fluoride / Q000378:metabolism*
chemical_list: D010710:Phosphates; C012980:fluorophosphate; D012969:Sodium Fluoride; D005459:Fluorides; D002118:Calcium