title: The prevention of an acute rise in intraocular pressure following Q-switched Nd:YAG laser iridotomy with clonidine.
abstract: We evaluated the ability of topical clonidine to suppress an acute rise in postoperative intraocular pressure (IOP) following Nd:YAG laser iridotomy. A total of 36 eyes (29 patients) with chronic primary angle-closure glaucoma underwent Q-switched Nd:YAG laser iridotomy: 18 eyes were treated topically with 0.5% clonidine ophthalmic solution prior to and immediately following the procedure, and a control group of 18 eyes underwent Nd:YAG laser iridotomy without topical clonidine. The control group was selected to match the clonidine-treated group in terms of preoperative IOP, the extent of peripheral anterior synechia, and the total amount of laser energy delivered. None of the clonidine-treated eyes experienced an IOP rise greater than 4 mm Hg over baseline, whereas 4 of the nontreated eyes (22.2%) developed an IOP rise greater than 10 mm Hg. The mean IOPs were significantly lower during the first 4 h postsurgery in the clonidine-treated eyes.
authors.affiliation: Department of Ophthalmology, Gifu University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kitazawa
authors.forename: K
authors.initials: K
authors.lastname: Sugiyama
authors.forename: T
authors.initials: T
authors.lastname: Taniguchi
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D003000:Clonidine / Q000627:therapeutic use*; D005260:Female; D005901:Glaucoma / Q000601:surgery*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007498:Iris / Q000601:surgery*; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D014065:Tonometry, Ocular
chemical_list: D003000:Clonidine