Selective effect of clonazepam and (S)-uxepam on the binding of warfarin enantiomers to human serum albumin.
Both clonazepam and (S)-uxepam selectively increase the binding of (S)-warfarin to human serum albumin. By liquid affinity chromatography, improved resolution of rac-warfarin was achieved.
Fitos
I
I
Central Research Institute for Chemistry of The Hungarian Academy of Sciences, Budapest.
Simonyi
M
M
D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D002998:Clonazepam / Q000494:pharmacology*; D006801:Humans; D011485:Protein Binding / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism*; D013237:Stereoisomerism; D014859:Warfarin / Q000097:blood*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D012709:Serum Albumin; D001569:Benzodiazepines; C039647:uxepam; D002998:Clonazepam; D014859:Warfarin