title: [Forensic medicine and toxicologic aspects of 2-propanol poisoning].
abstract: Two cases of poisoning with 2-propanol (isopropylalcohol) are reported. In one case, nail polish remover was drunk by a 2-year-old child. The concentration of 2-propanol and its metabolite acetone in the blood could be observed over a period of approximately 50 h. The highest concentration of 2-propanol determined was 4.22 g/l. Acetone reached a maximum value of 2.27 g/l 12 h after ingestion. The child survived without any observable after-effects. In the second case, a 35-year-old man drank ethanol in addition to 2-propanol. The poisoning was lethal. The possible time of intake before death is discussed in relation to the estimated levels of ethanol, 2-propanol and acetone found in the blood and urine. The histomorphological findings are often important as well with regard to time of intake.
authors.affiliation: Institut für Rechtsmedizin, Westfälischen Wilhelms-Universität Münster, Bundesrepublik Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Petkovits
authors.forename: G
authors.initials: G
authors.lastname: Bohn
authors.forename: B
authors.initials: B
authors.lastname: Brinkmann
mesh_terms: D000433:1-Propanol / Q000493:pharmacokinetics / Q000506:poisoning*; D000096:Acetone / Q000493:pharmacokinetics; D000328:Adult; D002675:Child, Preschool; D002849:Chromatography, Gas; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D006708:Homicide; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate
chemical_list: D000096:Acetone; D000433:1-Propanol
vernacular_title: Rechtsmedizinische und toxikologische Aspekte bei Propanol-2-Intoxikationen.