Regulation of glucose uptake in rat slow and fast skeletal muscles.
1. Regulation of glucose uptake was compared between extensor digitorum longus (EDL) and soleus (Sol) muscles in rats. 2. Insulin stimulated glucose uptake more in EDL than in Sol. 3. Under high concentrations of insulin, the glucose uptake was higher in EDL than Sol. 4. Inhibition of oxidative phosphorylation by anoxia or an uncoupler stimulated glucose uptake more in EDL than in Sol. 5. Anoxia abolished the effect of insulin on glucose uptake in both EDL and Sol. 6. The blocker to glucose transport system reduced glucose uptake more in Sol than in EDL.
Shoji
S
S
Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
D019297:2,4-Dinitrophenol; D019325:3-O-Methylglucose; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D003571:Cytochalasin B / Q000494:pharmacology; D004140:Dinitrophenols / Q000494:pharmacology; D005260:Female; D005947:Glucose / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D008757:Methylglucosides / Q000493:pharmacokinetics; D009132:Muscles / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D004140:Dinitrophenols; D007328:Insulin; D008757:Methylglucosides; D019325:3-O-Methylglucose; D003571:Cytochalasin B; D005947:Glucose; D019297:2,4-Dinitrophenol