UK-63,052 complex, new quinomycin antibiotics from Streptomyces braegensis subsp. japonicus; taxonomy, fermentation, isolation, characterisation and antimicrobial activity.
UK-63,052 complex, a new group of quinomycin-like antibiotics comprising UK-63,052 (factor A), UK-63,598 (factor C), UK-65,662 (factor B) and several uncharacterised minor components, is produced by a new subspecies of the genus Streptomyces for which the name Streptomyces braegensis Dietz subsp. japonicus, is proposed. The strain, N617-29, is characterised by a negative melanin reaction, grey aerial mycelium, spiral spore chains and smooth or slightly warty spores. Structure determination has identified UK-63,052, C56H68N10O14S2, UK-63,598, C53H62N10O14S2 and UK-65,662, C55H66N10O14S2 as quinaldic acid substituted quinomycins with unusual bridgehead sulfur substitution as shown in Fig. 3.
Rance
M J
MJ
Central Research Division, Pfizer Limited, Kent, England.
Ruddock
J C
JC
Pacey
M S
MS
Cullen
W P
WP
Huang
L H
LH
Jefferson
M T
MT
Whipple
E B
EB
Maeda
H
H
Tone
J
J
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D004448:Echinomycin / Q000031:analogs & derivatives / Q000302:isolation & purification*; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011810:Quinoxalines / Q000302:isolation & purification*; D012988:Soil Microbiology; D013053:Spectrophotometry; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D011810:Quinoxalines; C059304:UK 63052 complex; C010777:quinomycin; C059030:UK 63052; C059306:UK 63598; C059307:UK 65662; D004448:Echinomycin