Characterization of a human ovarian carcinoma cell line with estrogen and progesterone receptors.
The potential significant therapeutic and prognostic roles for the sex steroid receptors in ovarian cancer are recognized. The authors present in detail the biochemical, morphologic, cytogenetic, and growth characteristics of an ovarian carcinoma cell line, BG-1, which has functional estrogen and progesterone receptors (23 and 300 fmol/mg protein, respectively) in clinically significant levels. In particular, BG-1 has a DNA index of 1.14, a stable karyotype with specific translocations, and produces and secretes CA 125 into the media.
Geisinger
K R
KR
Department of Pathology, Wake Forest University, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.
Kute
T E
TE
Pettenati
M J
MJ
Welander
C E
CE
Dennard
Y
Y
Collins
L A
LA
Berens
M E
ME
D000230:Adenocarcinoma / Q000032:analysis* / Q000188:drug therapy / Q000648:ultrastructure; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D002871:Chromosome Banding; D003520:Cyclophosphamide / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007621:Karyotyping; D008297:Male; D051379:Mice; D008819:Mice, Nude; D010051:Ovarian Neoplasms / Q000032:analysis* / Q000188:drug therapy / Q000648:ultrastructure; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured
D014408:Biomarkers, Tumor; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D004317:Doxorubicin; D003520:Cyclophosphamide