[5-fluorodeoxyuridine induces radioresistant synthesis of DNA and sensitizes HeLa cells to gamma radiation].
It was shown that preincubation of HeLa cells with 5-fluorodeoxyuridine (10(-6) M) induced DNA synthesis resistant to gamma-radiation (6 Gy). At the same time, the death rate of exposed cells increased and nucleoid relaxation decreased. The role of DNA synthesis inhibitors in the reproductive death of exposed cells is discussed.
Synzynys
B I
BI
Brozmanova
E
E
Gotlib
V Ia
VIa
Saenko
A S
AS
D004273:DNA, Neoplasm / Q000096:biosynthesis*; D005467:Floxuridine / Q000494:pharmacology*; D006367:HeLa Cells / Q000187:drug effects / Q000528:radiation effects*; D006801:Humans; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*
D004273:DNA, Neoplasm; D011838:Radiation-Sensitizing Agents; D005467:Floxuridine
5-ftordezoksiuridin indutsiruet radiorezistentnyĭ sintez DNK i sensibiliziruet kletki HeLa k gamma-oblucheniiu.