title: Secretory carcinoma of the breast in adults: emphasis on late recurrence and metastasis.
abstract: Secretory (so-called juvenile) carcinoma of the breast, first described in children, occurs also in adult women, predominantly in the third decade. Less commonly it is seen in older age groups, up to the eighth decade. We report five patients with this tumour; one, a female aged 73, is the oldest age at which the tumour has been recorded, and one is the first report in an adult male in whom the disease recurred after 20 years, only the second recorded death attributable to this tumour type. Secretory carcinoma in adults is potentially more aggressive than in childhood. Nodal metastases are more frequent and sometimes more extensive. Recurrence of tumour after surgery developed in four of our five patients at 3, 8, 15 and 20 years. Slow growth and delayed recurrence are characteristic of many of these tumours. Death from systemic metastases is rare, but may ensue either rapidly or following a long latent period after treatment. Prolonged follow-up is needed to assess accurately the biological behaviour of this tumour.
authors.affiliation: Royal Postgraduate Medical School, London, UK.
authors.forename: T
authors.initials: T
authors.lastname: Krausz
authors.forename: D
authors.initials: D
authors.lastname: Jenkins
authors.forename: O
authors.initials: O
authors.lastname: Grontoft
authors.forename: D J
authors.initials: DJ
authors.lastname: Pollock
authors.forename: J G
authors.initials: JG
authors.lastname: Azzopardi
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000473:pathology*