title: Absolute ethanol renal angioinfarction for control of hypertension.
abstract: Six patients (11 renal units) underwent ethanol renal angioinfarction for medically uncontrollable hypertension. The mean preablation blood pressure was 175/112 mm Hg despite antihypertensive medications. Five of the patients demonstrated elevated renal vein renin levels prior to angioinfarction. Hypertension was improved in all 6 patients, during a mean follow-up period of fifty-one months. Systemic hypertension was completely eliminated in 4 patients. Two patients continue to require antihypertensive medication to control their hypertension. There were no major complications directly related to intra-arterial injection of ethanol. Transcatheter renal ablation employing intra-arterial injection of absolute ethanol for control of severe hypertension appears to be a safe and efficacious procedure. It should be considered an alternative to nephrectomy in selected high-risk patients.
authors.affiliation: Department of Surgery, University of Florida College of Medicine, Gainesville.
authors.forename: I W
authors.initials: IW
authors.lastname: Klimberg
authors.forename: D R
authors.initials: DR
authors.lastname: Locke
authors.forename: I F
authors.initials: IF
authors.lastname: Hawkins
authors.forename: D M
authors.initials: DM
authors.lastname: Drylie
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002648:Child; D004621:Embolization, Therapeutic; D000431:Ethanol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000628:therapy*; D008297:Male; D012077:Renal Artery
chemical_list: D000959:Antihypertensive Agents; D000431:Ethanol