title: [Prognosis and treatment of glomerulonephritis of periarteritis nodosa. The role of plasma exchange].
abstract: Fourteen patients with polyarteritis nodosa complicated by histologically confirmed glomerulopathies were included in a prospective multi-center study comparing corticotherapy (group 1, n = 8) with combined cyclophosphamide and steroids (group 2, n = 6). Plasma exchanges were associated on a routine basis. The two groups were comparable apart from initially more severe renal impairment in group 1 (p less than 0.05). Initial control of the disease was obtained in 11 patients (7 from group 1, 4 from group 2) including the patients with oligoanuria. Six patients recovered, 3 had recurrence requiring chronic hemodialysis and 5 patients died from group 1 (p less than 0.05). These preliminary findings suggest that plasma exchange can contribute to control of polyarteritis nodosa with renal complications.
authors.affiliation: Service de Médecine Interne, Hôpital Avicenne, Bobigny.
authors.forename: B
authors.initials: B
authors.lastname: Jarrousse
authors.forename: L
authors.initials: L
authors.lastname: Guillevin
authors.forename: S
authors.initials: S
authors.lastname: Gie
authors.forename: O
authors.initials: O
authors.lastname: Bletry
authors.forename: J
authors.initials: J
authors.lastname: Barrier
authors.forename: E
authors.initials: E
authors.lastname: Cassuto-Viguier
authors.forename: K S
authors.initials: KS
authors.lastname: Ang
authors.forename: J F
authors.initials: JF
authors.lastname: Besancenot
authors.forename: A
authors.initials: A
authors.lastname: Sobel
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003404:Creatinine / Q000097:blood; D003520:Cyclophosphamide / Q000627:therapeutic use; D005921:Glomerulonephritis / Q000097:blood / Q000188:drug therapy / Q000628:therapy*; D006801:Humans; D015337:Multicenter Studies as Topic; D010951:Plasma Exchange; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D000305:Adrenal Cortex Hormones; D003520:Cyclophosphamide; D003404:Creatinine
vernacular_title: Pronostic et traitement des glomérulonéphrites de la périartérite noueuse. Place des échanges plasmatiques.