title: Indomethacin and bone remodeling. Effect on cortical bone after osteotomy in rabbits.
abstract: Remodeling in cortical bone close to a plated tibial midshaft osteotomy was histomorphometrically evaluated in 32 rabbits. The animals were divided into two groups, one being treated with indomethacin (10 mg/kg per day) and the other receiving placebo. In the placebo-treated group, the remodeling activity was higher in the osteotomized leg compared with the intact leg. Two and 6 weeks after osteotomy, the number of resorptive and formative foci was reduced in the indomethacin-treated group compared with the placebo group. Porosity did not differ between the groups after 2 weeks; but after 6 weeks, it was reduced in the indomethacin-treated animals. Throughout the study, the bone formation rate did not differ between the two groups. This study demonstrates that indomethacin inhibits the remodeling of traumatized bone.
authors.affiliation: University of Arhus, Institute of Experimental Clinical Research, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Keller
authors.forename: I
authors.initials: I
authors.lastname: Bayer-Kristensen
authors.forename: B
authors.initials: B
authors.lastname: Bak
authors.forename: C
authors.initials: C
authors.lastname: Bünger
authors.forename: P
authors.initials: P
authors.lastname: Kjaersgaard-Andersen
authors.forename: U
authors.initials: U
authors.lastname: Lucht
authors.forename: F
authors.initials: F
authors.lastname: Melsen
mesh_terms: D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D001860:Bone Plates; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology; D007213:Indomethacin / Q000494:pharmacology*; D010027:Osteotomy; D011817:Rabbits; D013977:Tibia / Q000601:surgery
chemical_list: D007213:Indomethacin