[Mechanisms of the thrombocytic effects of beta-adrenoblockaders].
Beta-adrenoblockers were found to be able of suppressing platelet aggregation through beta 2-subtype of adrenoreceptors. This is due to the membrane-stabilizing action of beta-adrenoblockers which by binding to the receptors decrease microviscosity of the membranes and prevent the opposite shift under the influence of aggregation inductors.
Tumasian
K S
KS
Akopov
S E
SE
Gabrielian
E S
ES
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D001809:Blood Viscosity / Q000187:drug effects; D002118:Calcium / Q000097:blood; D002462:Cell Membrane / Q000187:drug effects; D003094:Collagen / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D005456:Fluorescent Dyes; D006801:Humans; D066298:In Vitro Techniques; D008563:Membrane Lipids / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D005456:Fluorescent Dyes; D008563:Membrane Lipids; D000244:Adenosine Diphosphate; D003094:Collagen; D002118:Calcium; D004837:Epinephrine
Issledovanie mekhanizmov trombotsitarnykh éffektov beta-adrenoblokatorov.