Metallothionein-I accumulation in the rat lung following a single paraquat administration.
The ability of paraquat (PQ), a free radical inducible chemical, to increase metallothionein-I (MT-I) content in the tissues was determined using radioimmunoassay. A single dose of PQ into the rat caused a sevenfold increase in pulmonary MT-I concentration on day 1 and its concentration returned to the control level by day 5. Paraquat-induced increase in MT-I was not observed in the kidney, but was seen in the liver. The data show the difference in accumulation of MT-I in liver, kidney and lung after intraperitoneal injection of a high dose of PQ.
Sato
M
M
Division of Environmental Pollution Research, Fukushima Medical College, Japan.
Ohtake
A
A
Takeda
K
K
Mizunuma
H
H
Nagai
Y
Y
D000818:Animals; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism*; D008297:Male; D008668:Metallothionein / Q000097:blood / Q000378:metabolism*; D010269:Paraquat / Q000008:administration & dosage* / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D008668:Metallothionein; D010269:Paraquat