title: Massive follicular lymphoid hyperplasia in experimental allergic conjunctivitis. Local antibody production.
abstract: Acute and recurrent allergic conjunctival reactions were induced in guinea pigs by repeated conjunctival applications of fluoresceinyl ovalbumin (FL-OA) for up to 30 months. Early type I conjunctival reactions developed 11 to 25 days after the initial conjunctival exposure to FL-OA. Continuous topical challenges during a six- to 30-month period caused a variety of reactions, including papillary changes and massive hyperplasia of the conjunctival-associated lymphoid tissues. Hyperplasia of lymphoid tissues was induced during a shorter period (two to five months) with a mixture of FL-OA and phorbol ester. Culture fluid from hyperplastic conjunctival lymphoid tissue showed a ratio of IgG1/IgG2 antibody production of up to 15. A low level of recurrence of type I reactivity, after an initial desensitization phenomenon due to a loss of reactive mast cells, correlated with prominent follicular hyperplasia of the conjunctival-associated lymphoid tissue.
authors.affiliation: Department of Ophthalmology Scheie Eye Institute, School of Medicine, University of Pennsylvania, Philadelphia 19104.
authors.forename: M
authors.initials: M
authors.lastname: Khatami
authors.forename: J J
authors.initials: JJ
authors.lastname: Donnelly
authors.forename: J P
authors.initials: JP
authors.lastname: Haldar
authors.forename: Z G
authors.initials: ZG
authors.lastname: Wei
authors.forename: J H
authors.initials: JH
authors.lastname: Rockey
mesh_terms: D000818:Animals; D000917:Antibody Formation; D002478:Cells, Cultured; D003228:Conjunctiva / Q000473:pathology*; D003233:Conjunctivitis, Allergic / Q000276:immunology* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006168:Guinea Pigs; D006965:Hyperplasia; D007074:Immunoglobulin G / Q000032:analysis; D008221:Lymphoid Tissue / Q000473:pathology*; D009924:Organ Culture Techniques; D010047:Ovalbumin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; C042851:fluorescein-ovalbumin; D010047:Ovalbumin