Dopaminergic modulation of the diethylstilbestrol-induced proliferation of the anterior pituitary gland of the Fisher 344 rat.
Bromocriptine (CB 154), a potent agonist upon the D-2 receptor, blocks the proliferation of the mammotrophs and the elevation of serum prolactin concentration induced by chronic exposure of male Fisher 344 rats to diethylstilbestrol (DES). Fluphenazine, a dopamine receptor antagonist, blocks these effects of CB 154. We conclude that a D-2 receptor occurs on the proliferating mammotroph of the male Fisher 344 rat and that stimulation of this receptor inhibits prolactin release and stops the DES-induced proliferation of these cells.
Miyazaki
K
K
Dambrosia
J M
JM
Kebabian
J W
JW
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004347:Drug Interactions; D005476:Fluphenazine / Q000494:pharmacology; D008297:Male; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D017448:Receptors, Dopamine D2
D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D001971:Bromocriptine; D004054:Diethylstilbestrol; D011388:Prolactin; D005476:Fluphenazine