title: Putative neurotransmitters in the rat cochlea at several ages.
abstract: We have performed a longitudinal study of the content of the putative neurotransmitter substances, enkephalin, dynorphin, and acetylcholine (ACh), in the cochlea of the Fischer 344 rat. It is the first study of transmitters in the rat cochlea over an extended time span. This study also provides biochemical verification of the presence of ACh in cochlear tissues. No change was seen in the cochlear content of these transmitter candidates up to 24 months of age.
authors.affiliation: Department of Psychiatry, Dartmouth Medical School, Hanover, NH.
authors.forename: D W
authors.initials: DW
authors.lastname: Hoffman
authors.forename: K L
authors.initials: KL
authors.lastname: Jones-King
authors.forename: R A
authors.initials: RA
authors.lastname: Altschuler
mesh_terms: D000109:Acetylcholine / Q000032:analysis*; D000375:Aging; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003051:Cochlea / Q000254:growth & development*; D004399:Dynorphins / Q000032:analysis*; D004745:Enkephalins / Q000032:analysis*; D018377:Neurotransmitter Agents / Q000032:analysis*; D011863:Radioimmunoassay; D051381:Rats; D011916:Rats, Inbred F344; D012016:Reference Values
chemical_list: D004745:Enkephalins; D018377:Neurotransmitter Agents; D004399:Dynorphins; D000109:Acetylcholine