Passive transfer of HIV antibody by hepatitis B immune globulin.
Two newborns of mothers carrying hepatitis B and at high risk for human immunodeficiency virus (HIV) infection developed HIV-positive test results by enzyme-linked immunosorbent assay and Western blot tests after birth. Both had been administered hepatitis B immune globulin within 48 hours of birth. Serological tests detected HIV antibody as long as 17 days after birth. Both newborns had received lots of hepatitis B immune globulin containing antibody to HIV. While hepatitis B immune globulin cannot transmit HIV infection to recipients, physicians should be aware that administration of older lots of this preparation may result in transiently positive tests for HIV antibody in the recipients. Lots manufactured from screened plasma do not contain antibody to HIV.
Schlech
W F
WF
Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia.
Lee
S H
SH
Cook
J
J
Rozee
K R
KR
MacIntosh
N
N
D000328:Adult; D005260:Female; D006679:HIV Seropositivity / Q000209:etiology*; D006509:Hepatitis B / Q000517:prevention & control*; D006801:Humans; D007116:Immunization, Passive / Q000009:adverse effects*; D007136:Immunoglobulins / Q000008:administration & dosage*; D007231:Infant, Newborn; D008297:Male
D007136:Immunoglobulins; C045213:hepatitis B hyperimmune globulin