Coincidence of fundic glandular hyperplasia and carcinoma of the stomach.
Eight patients with stomach cancer are described who had also a striking glandular hyperplasia of the fundic mucosa adjacent and remote from the tumor. Five of the eight patients were young women (30 to 37 years of age). The tumors were poorly differentiated carcinomas and six of the eight patients have died of their disease. None of the patients had clinical evidence of endocrine dysfunction including the Zollinger-Ellison syndrome. Immunohistochemistry revealed cells with endocrine differentiation in five of eight tumors, and in two tumors gastrin producing cells were found. Five of seven patients showed increased numbers of antral G-cells. In two patients numerous endocrine (chromogranin-positive) cells were present in the fundic mucosa, specific products of which could not be identified with the antigens tested. No satisfactory explanation exists for this coincidence and its apparent predominance in young female patients. It may be that endocrine substances are responsible for this fundic hyperplasia and that they may also act as promotors of tumor growth.
Stamm
B
B
Institute of Pathology, University Hospital, Zürich, Switzerland.
Saremaslani
P
P
D000328:Adult; D002277:Carcinoma / Q000032:analysis / Q000473:pathology*; D005260:Female; D005748:Gastric Fundus / Q000032:analysis / Q000473:pathology*; D005753:Gastric Mucosa / Q000032:analysis; D005755:Gastrins / Q000032:analysis; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013274:Stomach Neoplasms / Q000032:analysis / Q000473:pathology*
D005755:Gastrins