The Drosophila gene torso encodes a putative receptor tyrosine kinase.
The maternal gene torso, required for determination of anterior and posterior terminal structures in the Drosophila embryo, was cloned using P-element tagging. Genetic evidence suggests that the action of the gene product is spatially restricted to the terminal regions; the torso messenger RNA, however, is evenly distributed. Structural similarities of the predicted torso protein with growth-factor receptor tyrosine kinases suggest that the spatial restriction of torso activity results from a localized activation of the torso protein at the anterior and posterior egg pole.
Sprenger
F
F
Max-Planck-Institut für Entwicklungsbiologie, Abteilung Genetik, Tübingen, FRG.
Stevens
L M
LM
Nüsslein-Volhard
C
C
D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D003001:Cloning, Molecular; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D005796:Genes; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D015183:Restriction Mapping
D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases