title: New products related to kinamycin from Streptomyces murayamaensis. II. Structures of pre-kinamycin, keto-anhydrokinamycin, and kinamycins E and F.
abstract: Four new colored components of Streptomyces murayamaensis sp. nov. Hata et Ohtani, the producer of the kinamycins, have been isolated and their structures determined by a combination of mass spectral, high field NMR and biosynthetic techniques. The first compound with the benz[b]carbazole skeleton in the biosynthetic pathway of kinamycin D has been named "pre-kinamycin" (7). A keto-epoxide kinamycin intermediate has been labeled "keto-anhydrokinamycin" (9), and the 1'-monoacetate of kinamycin has been called kinamycin E (12). Natural production of deacetylkinamycin (13, now labeled kinamycin F) by S. murayamaensis has been confirmed by an isotope trapping experiment. The role of these new intermediates in kinamycin biosynthesis is discussed.
authors.affiliation: Department of Chemistry, Oregon State University, Corvallis 97331.
authors.forename: P J
authors.initials: PJ
authors.lastname: Seaton
authors.forename: S J
authors.initials: SJ
authors.lastname: Gould
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011809:Quinones / Q000302:isolation & purification; D013302:Streptomyces / Q000378:metabolism*; D000095602:Angucyclines and Angucyclinones
chemical_list: D000900:Anti-Bacterial Agents; D011809:Quinones; C059018:pre-kinamycin; D000095602:Angucyclines and Angucyclinones; C059019:keto-anhydrokinamycin; C059020:kinamycin E; C059021:kinamycin F