Evidence for the glycation hypothesis of aging from the food-restricted rodent model.
Glucose has been proposed as a mediator of aging processes by means of glycation reactions resulting in advanced glycosylation end-products, thereby altering protein and DNA function. Testing this provocative concept has a high priority in gerontologic research. In this study, food restriction of rats--a procedure which markedly retards aging processes--was used to test the glycation hypothesis. Food-restricted rats were found to have a sustained plasma glucose concentration and percentage glycosylation of hemoglobin significantly lower than those of ad libitum fed rats. These findings are consistent with and provide support for the glycation hypothesis.
Masoro
E J
EJ
Department of Physiology, University of Texas Health Science Center, San Antonio.
Katz
M S
MS
McMahan
C A
CA
D000375:Aging / Q000097:blood*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005508:Food Deprivation / Q000502:physiology*; D006442:Glycated Hemoglobin / Q000378:metabolism; D008297:Male; D011499:Protein Processing, Post-Translational; D051381:Rats; D011916:Rats, Inbred F344
D001786:Blood Glucose; D006442:Glycated Hemoglobin