A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells.
An enzyme in homogenates of porcine vascular endothelial cells forms L-citrulline from L-arginine. This enzyme is soluble and NADPH-dependent. In addition, the enzyme is inhibited by NG-monomethyl-L-arginine, suggesting that it is involved in the formation of nitric oxide by vascular endothelial cells.
Palmer
R M
RM
Wellcome Research Laboratories, Langley Court, Beckenham, U.K.
Moncada
S
S
D000818:Animals; D001013:Aorta, Thoracic; D001120:Arginine / Q000378:metabolism; D002478:Cells, Cultured; D002956:Citrulline / Q000096:biosynthesis*; D004730:Endothelium, Vascular / Q000201:enzymology*; D009569:Nitric Oxide / Q000378:metabolism*; D013552:Swine
D002956:Citrulline; D009569:Nitric Oxide; D001120:Arginine