[The alpha-adrenergic sensitivity of smooth muscle following sympathectomy].
The effect of sympathetic nerve stimulation on postsynaptic alpha-adrenoceptors of cat's smooth muscle nictitating membrane was studied. L-noradrenaline, adrenaline, phenylephrine and clonidine caused a concentration-dependent contraction. In denervated tissue, the concentration-response curve for clonidine mainly shifted to the left in comparison with the control; in contrast to the innervated smooth muscle, there were no reliable differences between the constant dissociation Ka and KB for alpha 1- and alpha 2-selective and nonselective adrenomimetics and adrenoblockaders. The data obtained suggest alteration of pharmacological characteristics of smooth muscle alpha-adrenoceptors after interruption of the sympathetic nerve.
Telina
E N
EN
Khamitov
Kh S
KhS
Akhmedzianov
R Kh
RKh
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D009119:Muscle Contraction / Q000187:drug effects; D009121:Muscle Denervation; D009130:Muscle, Smooth / Q000294:innervation / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D012044:Regression Analysis; D013562:Sympathectomy
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D011942:Receptors, Adrenergic, alpha
Al'fa-adrenergicheskaia chuvstvitel'nost' gladkoĭ myshtsy posle desimpatizatsii.