Effect of pentobarbital on gastric acid secretion elicited by secretagogues or electrical vagal stimulation in rats under urethane anesthesia.
The effect of pentobarbital, which stimulates gastric acid secretion in urethane-anesthetized rats, on secretagogue-stimulated or electrically stimulated acid secretion was studied in the rat perfused stomach. 2-Deoxy-D-glucose (2-DG)-stimulated gastric acid secretion was markedly depressed by intravenous injection of pentobarbital, but was definitely increased by lateral cerebroventricular injection and was unaffected by injection into the fourth cerebroventricle. Bethanechol-stimulated secretion was augmented by intravenous injection of pentobarbital. In vagotomized rats, pentobarbital did not affect the bethanechol-stimulated or electrically vagally stimulated secretion. These findings indicate that pentobarbital produces both stimulatory and inhibitory effects on gastric acid secretion through a central mechanism, especially in the forebrain. It was proposed that the inhibitory response would result from some interaction of intravenous 2-DG and pentobarbital in the central regulatory system of gastric secretion.
Yano
S
S
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba, Japan.
Lin
W C
WC
Watanabe
K
K
D000818:Animals; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000494:pharmacology; D003847:Deoxyglucose / Q000494:pharmacology; D004558:Electric Stimulation; D005744:Gastric Acid / Q000378:metabolism*; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D010424:Pentobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000502:physiology
D001626:Bethanechol Compounds; D018723:Bethanechol; D003847:Deoxyglucose; D010424:Pentobarbital