title: Tolerance to phenelzine and subsequent refractory depression: three cases.
abstract: Three patients with major depression superimposed on chronic dysthymia were treated with phenelzine. After an initial excellent response, each patient relapsed and developed a severe chronic depression that was refractory to other treatments. The implications for the long-term effects of phenelzine treatment are considered.
authors.affiliation: Department of Psychiatry, St. Elizabeth's Hospital, Boston, MA 02135.
authors.forename: S R
authors.initials: SR
authors.lastname: Donaldson
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010624:Phenelzine / Q000009:adverse effects / Q000627:therapeutic use*; D012008:Recurrence
chemical_list: D010624:Phenelzine