[Participation of the cholinergic system in the development of hemodynamic effects of GABA, administered intrabulbarly].
Acute experiments in cats revealed effects of GABA injections (2.10(-5)-5.10(-5) M/l) into the neuronal structures of the dorso-medial medulla after M-cholinoreceptors had been blocked. Hypotensive action of GABA injected into the n. ambiguous and ventral reticular nucleus was shown to be actualized through participation of bulbar M-cholinoreceptors. Effects of GABA injected into n. tractus solitarius occurred with no consistent participation of the central M-cholinoreceptors.
Shapoval
L N
LN
Pobegaĭlo
L S
LS
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D006439:Hemodynamics / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects / Q000294:innervation; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D008845:Microinjections; D009476:Neurons, Efferent / Q000187:drug effects / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology*
D011976:Receptors, Muscarinic; D005680:gamma-Aminobutyric Acid
Uchastie kholinergicheskoì sistemy v razvitii gemodinamicheskikh éffektov gamma-aminomaslianĭ kosloty, vvedennoĭ intrabul'barno.