title: Identification of gamma-aminobutyric acid-like immunoreactive neurons in the rat cuneate nucleus.
abstract: Neurons in the cuneate nucleus of the rat were examined for gamma-aminobutyric acid-like immunoreactivity (GABA-LI) using antiserum raised against GABA-glutaraldehyde-keyhole limpet hemocyanin. GABA-LI neurons were analyzed for size, shape, and distribution and compared to Nissl-stained neurons. GABA-LI cell bodies were located at all rostral-caudal levels and were distributed randomly throughout the nucleus except at the level of the obex, where they were limited to the peripheral region of the cuneate nucleus. GABA-LI cell bodies had a significantly smaller mean cross-sectional area than the total cuneate neuronal population and comprised 21.5% of the total neuronal population as assessed with Nissl-staining. These results are consistent with the hypothesis that GABA is involved in processing somatosensory information in the rat dorsal column nuclei.
authors.affiliation: Department of Anatomy, School of Medicine, Wright State University, Dayton, OH 45435.
authors.forename: V R
authors.initials: VR
authors.lastname: Roettger
authors.forename: J C
authors.initials: JC
authors.lastname: Pearson
authors.forename: M D
authors.initials: MD
authors.lastname: Goldfinger
mesh_terms: D000818:Animals; D002452:Cell Count; D007150:Immunohistochemistry; D008526:Medulla Oblongata / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid