title: Utilization of femoral head for estimating the skeletal burden of U and Pu in humans.
abstract: Uranium and Pu were determined in vertebrae, ribs and femoral head samples obtained from the same population. Vertebrae and rib samples were obtained at autopsy and femoral head samples were obtained from persons undergoing hip surgery. The results indicate that there was no statistically (p less than or equal to 0.05) significant difference between the mean concentration of 239,240Pu in vertebrae and ribs. Also, there was no significant difference between the mean concentration of 239,240 Pu in ribs and femoral head. Also, statistical tests were performed to see whether the mean concentrations of 238U and 234U in three different bones differ from each other. The results suggest that there was no statistically significant difference between vertebrae and ribs, vertebrae and head of the femur nor between ribs and femoral head. These results indicate that femoral head may be an appropriate substitute for vertebrae or ribs, the most commonly used bone for inferring the skeletal burden of U and Pu in human. Femoral head samples can be obtained from living persons undergoing hip surgery, while vertebrae and ribs are obtained only at autopsy.
authors.affiliation: Radiobiology Laboratory, School of Medicine, University of Utah, Salt Lake City 84112.
authors.forename: N P
authors.initials: NP
authors.lastname: Singh
authors.forename: L L
authors.initials: LL
authors.lastname: Lewis
authors.forename: M E
authors.initials: ME
authors.lastname: Wrenn
mesh_terms: D001822:Body Burden; D005270:Femur Head / Q000032:analysis*; D006801:Humans; D011005:Plutonium / Q000032:analysis*; D012272:Ribs / Q000032:analysis; D013131:Spine / Q000032:analysis; D014501:Uranium / Q000032:analysis*
chemical_list: D014501:Uranium; D011005:Plutonium