A large animal model (swine) to study the diagnosis and treatment of cholelithiasis.
Human gallstones were surgically placed into the gallbladders of 200 swine. Eight of these swine were used as a prospective series to verify that the placement and presence of human gallstones in their gallbladders caused no significant pathologic changes in the gallbladder and that the gallstones were not spontaneously dissolved. Although limitations exist, the advantages of this procedure demonstrate that the surgically prepared swine is an appropriate model for controlled in vivo experiments in radiologic imaging or interventional treatment. A 4 F pig-tailed catheter designed for Trocar insertion was developed as a companion to this model.
Griffith
S L
SL
Indianapolis Center for Advanced Research, Inc., IN 46204.
Burney
B T
BT
Fry
F J
FJ
Franklin
T D
TD
D000818:Animals; D001646:Bile / Q000032:analysis; D001647:Bile Acids and Salts / Q000032:analysis; D002769:Cholelithiasis / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D002784:Cholesterol; D004195:Disease Models, Animal; D011446:Prospective Studies; D013552:Swine
D001647:Bile Acids and Salts; D002784:Cholesterol