Clenbuterol stimulated increase of plasma free fatty acids in reserpinized pigs.
1. Previous studies indicate the beta-adrenergic agonist, clenbuterol, does not stimulate porcine adipose tissue lipolysis or cAMP concentration in vitro but increases plasma free fatty acid concentrations when infused, implying an indirect mechanism in vivo. 2. One indirect mechanism is the release of endogenous catecholamines to increase adipose tissue lipolysis and raise plasma free fatty acids. 3. In pigs treated with reserpine to deplete endogenous catecholamines, clenbuterol infusion increased plasma free fatty acids concentration suggesting that this increase in vivo did not result from release of endogenous catecholamines.
Hu
C Y
CY
Department of Animal Sciences, University of Illinois, Urbana 61801.
Novakofski
J
J
Mersmann
H J
HJ
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D002976:Clenbuterol / Q000494:pharmacology*; D004983:Ethanolamines / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006339:Heart Rate / Q000187:drug effects; D008066:Lipolysis / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology*; D013552:Swine
D002395:Catecholamines; D004983:Ethanolamines; D005230:Fatty Acids, Nonesterified; D012110:Reserpine; D002976:Clenbuterol