Normalization by dietary cod-liver oil of reduced thrombogenesis in essential fatty acid deficient rats.
Rats, deficient in essential fatty acids (EFA), were given diets containing 5 energy% sunflowerseed oil (SO, rich in linoleic acid), cod-liver oil (CLO, rich in timnodonic acid and cervonic acid), or hydrogenated coconut oil (HCO), containing no EFAs at all. SO and CLO feeding resulted in normalization of the reduced arterial thrombus formation in EFA-deficient animals. SO feeding was associated with the normalization of the arachidonic acid content of platelet phospholipids. CLO feeding did not have this effect but greatly increased the availability of timnodonic acid (EPA) and cervonic acid (DHA). Further research is required to investigate whether these changes in fatty acid composition can be hold responsible for the normalizing effect of dietary CLO on the disturbed arterial thrombosis tendency in EFA deficient rats, possibly via the formation of eicosanoids.
Hornstra
G
G
Department of Nutrition and Safety, Unilever Research, Vlaardingen, The Netherlands.
Haddeman
E
E
Don
J A
JA
D000818:Animals; D000074263:Coconut Oil; D003060:Cod Liver Oil / Q000008:administration & dosage / Q000627:therapeutic use*; D004041:Dietary Fats / Q000627:therapeutic use; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005228:Fatty Acids, Essential / Q000172:deficiency*; D005395:Fish Oils / Q000627:therapeutic use*; D008297:Male; D010938:Plant Oils / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D000074242:Sunflower Oil; D013927:Thrombosis / Q000188:drug therapy*
D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005228:Fatty Acids, Essential; D005395:Fish Oils; D010938:Plant Oils; D000074242:Sunflower Oil; D003060:Cod Liver Oil; D000074263:Coconut Oil