Ionophoretic-like action of diflunisal.
It is shown that diflunisal, a derivative salicylic acid, causes uncoupling of oxidative phosphorylation owing to its property of carrying hydrogen ions through the inner mitochondrial membrane in such way that a short-circuit of protons is promoted. As a consequence of the above, the drug induces a decrease of the internal negative membrane potential and therefore the release of intramitochondrial calcium. In addition this report presents evidences that diflunisal behaves as a ionophore molecule since it induces cation extraction into an organic phase.
Chávez
E
E
Bravo
C
C
Gil
H A
HA
Reyes
P A
PA
D020001:1-Butanol; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D000440:Butanols; D002118:Calcium / Q000378:metabolism; D004061:Diflunisal / Q000494:pharmacology*; D004285:Dogs; D004996:Ethidium / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008564:Membrane Potentials / Q000187:drug effects; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D009840:Oligomycins / Q000494:pharmacology; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D012459:Salicylates / Q000494:pharmacology*; D014050:Toluene
D000440:Butanols; D009840:Oligomycins; D012459:Salicylates; D014050:Toluene; D004061:Diflunisal; D020001:1-Butanol; D000251:Adenosine Triphosphatases; D004996:Ethidium; D002118:Calcium