title: Paraneoplastic hypercalcemia in endometrial carcinoma.
abstract: Humoral hypercalcemic syndrome associated with tumors of the female reproductive system is believed to be uncommon, and only 27 such cases have been identified prior to 1980. We describe 2 patients with humoral hypercalcemia in clear cell adenocarcinoma of the uterus, and review the literature on previously published cases. Both our patients fulfilled the criteria for humoral hypercalcemic syndrome, namely: hypercalcemia without bone metastases ranging from 12.8 to 14.1 mg/dl in the presence of normal serum parathyroid hormone levels, reduced tubular reabsorption of phosphate, and reduced serum albumin. We propose that humoral hypercalcemia is perhaps not a rare complication of uterine malignancy and, that increased awareness may result in early diagnosis of this important metabolic problem.
authors.affiliation: Department of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
authors.forename: N
authors.initials: N
authors.lastname: Hiller
authors.forename: M
authors.initials: M
authors.lastname: Sonnenblick
authors.forename: C
authors.initials: C
authors.lastname: Hershko
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D010281:Parathyroid Hormone / Q000097:blood; D015291:Transforming Growth Factors / Q000502:physiology; D014594:Uterine Neoplasms / Q000150:complications*
chemical_list: D010281:Parathyroid Hormone; D015291:Transforming Growth Factors