Effects of human fetal liver extract on the growth of HL-60 cells.
Two kinds of HL-60 cell growth suppressor present in human fetal liver were studied. One is the already known arginase, which showed nonspecific suppression on the growth of HL-60 cells and human granulocyte-macrophage progenitors (CFU-GM), and the other, a new species of suppressor with the characteristics of lower molecular weight (less than 10,000 daltons), shows preferential suppression on HL-60 cell growth, but less effect on the growth of CFU-GM.
Wu
C T
CT
Department of Experimental Hematology, Beijing Institute of Radiation Medicine, China.
Pei
X T
XT
Cong
P J
PJ
D001119:Arginase / Q000378:metabolism; D001853:Bone Marrow; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002474:Cell-Free System; D005591:Chemical Fractionation; D005333:Fetus; D006131:Growth Inhibitors / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology*; D008110:Liver Extracts / Q000032:analysis / Q000502:physiology*; D008970:Molecular Weight; D014407:Tumor Cells, Cultured; D014462:Ultrafiltration
D006131:Growth Inhibitors; D008110:Liver Extracts; D001119:Arginase