Epidural analgesia with bupivacaine reduces postoperative paralytic ileus after hysterectomy.
This study was undertaken to compare the effects of postoperative bupivacaine epidural analgesia with those of intermittent injections of ketobemidone (a synthetic opioid) on postoperative bowel motility in patients who had had hysterectomies. The epidural group (N = 20) received continuous epidural anesthesia with bupivacaine postoperatively for 26-30 hours and the control group (N = 20) received intermittent injections of ketobemidone for postoperative pain relief. Postoperative bowel movements and propulsive colonic motility were estimated from the first passage of flatus and feces and by following radiopaque markers by serial abdominal radiographs. In the epidural group, the times for first passing of flatus (31 +/- 22 hours; mean +/- SD) and feces (70 +/- 44 hours) were significantly shorter than in the control group (flatus 58 +/- 14 hours and feces 103 +/- 26 hours). The average position of the markers was significantly more distally in the epidural group immediately after operation and the markers continued to move forward during the first postoperative day. In the control group, the markers did not move during this period. The results demonstrate that postoperative bowel peristalsis returned earlier in the patients given epidural analgesia with bupivacaine for pain relief than in patients given a narcotic.
Wattwil
M
M
Department of Anesthesiology, Orebro Medical Center Hospital, Sweden.
Thorén
T
T
Hennerdal
S
S
Garvill
J E
JE
D000328:Adult; D015360:Analgesia, Epidural; D002045:Bupivacaine / Q000008:administration & dosage*; D003672:Defecation; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D007415:Intestinal Obstruction / Q000517:prevention & control*; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy; D011183:Postoperative Complications / Q000517:prevention & control*
D002045:Bupivacaine