title: Increased efficacy and toxicity of lidocaine in patients on beta-blockers.
abstract: The greatest differences in ventricular arrhythmias and adverse effects of lidocaine observed in this study were between patients on both lidocaine and a beta-adrenoceptor blocking agent and those on neither drug. Although free fractions of lidocaine and methylglycylxylidine tended to be higher in patients on beta-adrenoceptor blocking agents, this difference was not significant nor were any other differences in serum drug levels observed.
authors.affiliation: Department of Medicine (Division of Cardiology), Faculty of Medicine, University of Calgary, Alberta, Canada.
authors.forename: D G
authors.initials: DG
authors.lastname: Wyse
authors.forename: J
authors.initials: J
authors.lastname: Kellen
authors.forename: Y
authors.initials: Y
authors.lastname: Tam
authors.forename: A W
authors.initials: AW
authors.lastname: Rademaker
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D009961:Orosomucoid / Q000378:metabolism; D011897:Random Allocation
chemical_list: D000319:Adrenergic beta-Antagonists; D009961:Orosomucoid; D008012:Lidocaine