title: Quantitative study of the effects of maternal hyperthermia on cell death and proliferation in the guinea pig brain on day 21 of pregnancy.
abstract: On embryonic day 21, pregnant guinea pigs were exposed to a 44 degrees C environment for 1 hour. As a result, all brain ventricular zone cells in M phase of the mitotic cycle when heat-shock occurred became immediately pyknotic and all cell division was stopped for 4-8 hr. The pyknotic cells were removed at a definable rate until mitosis resumed, after which removal occurred in an apparently random manner. Long delays in the return to mitosis were related to increased destruction of S-phase cells deep within the ventricular zone and largely confined to the alar lamina. Upon recovery, a rostrocaudal delay in mitosis was apparent, and the number of mitotic figures was increased compared with control numbers for 1 hr, after which they returned to control numbers. It was evident that up to 40% of the cells within the ventricular zone were destroyed following brief maternal heat stress.
authors.affiliation: School of Anatomy, University of New South Wales, Sydney, Australia.
authors.forename: J B
authors.initials: JB
authors.lastname: Upfold
authors.forename: M S
authors.initials: MS
authors.lastname: Smith
authors.forename: M J
authors.initials: MJ
authors.lastname: Edwards
mesh_terms: D000818:Animals; D001921:Brain / Q000002:abnormalities* / Q000473:pathology; D002470:Cell Survival; D005260:Female; D005865:Gestational Age; D006168:Guinea Pigs; D006979:Hyperthermia, Induced / Q000009:adverse effects*; D008938:Mitosis; D011247:Pregnancy; D013997:Time Factors