title: Restrictions on use of creatinine clearance for measurement of renal functional reserve.
abstract: The increase of glomerular filtration rate after a 90-gram oral protein load was determined in 9 healthy individuals by simultaneous measurements of both creatinine (Ccr) and inulin (Cin) clearances, performed before and every 30 min during 4 h after the meat meal. This protein load resulted in a short 26% increase of Cin at 90 min, and a sustained 29% increase of Ccr from 90 to 240 min after load. Individual peak values of Ccr occurred later than those of Cin (Ccr: 189 +/- 19 vs. Cin: 127 +/- 19 min; p = 0.023). These discrepancies were related to an increase of serum creatinine, and a subsequent increase of the net tubular excretion of creatinine which accounted for up to 15% of the urinary creatinine. The creatinine content of red meat could lead to overestimation of renal functional reserve when measured by creatinine clearance only.
authors.affiliation: Département de Néphrologie, Université Claude-Bernard Lyon I, Unité INSERM U 80-CNRS UA 1177, Hôpital Edouard-Herriot, Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Laville
authors.forename: A
authors.initials: A
authors.lastname: Hadj-Aissa
authors.forename: N
authors.initials: N
authors.lastname: Pozet
authors.forename: J H
authors.initials: JH
authors.lastname: Le Bras
authors.forename: M
authors.initials: M
authors.lastname: Labeeuw
authors.forename: P
authors.initials: P
authors.lastname: Zech
mesh_terms: D000328:Adult; D003404:Creatinine / Q000378:metabolism*; D004044:Dietary Proteins / Q000008:administration & dosage; D005919:Glomerular Filtration Rate; D006801:Humans; D007444:Inulin / Q000378:metabolism; D007677:Kidney Function Tests; D008460:Meat
chemical_list: D004044:Dietary Proteins; D007444:Inulin; D003404:Creatinine