Absence of significant autosomal lesions in Huntington's disease.
Peripheral blood from six patients with Huntington's disease (HD) and six controls were cultured in three types of media known to produce fragile sites. A total of 3000 metaphases per group were scrutinized in a blind coded study. No significantly specific 'hot-spot' was found capable of differentiating between HD patients and controls.
Beverstock
G C
GC
Mol
A
A
Wienhofer
E
E
D000293:Adolescent; D000328:Adult; D000368:Aged; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002478:Cells, Cultured; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D003470:Culture Media; D005260:Female; D005467:Floxuridine / Q000494:pharmacology; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic
D003470:Culture Media; D005467:Floxuridine; D001973:Bromodeoxyuridine