A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells.
The complementary DNA coding for a lymphocyte-specific transcription factor binding to the DNA 'octamer' sequence TNATTTGCAT has been cloned. The nucleotide sequence shows homology to the homoeobox domain. Expression of this cDNA in HeLa cells is sufficient for a strong transcriptional activation of B-cell-specific promoters.
Müller
M M
MM
Institut für Molekularbiologie II der Universität Zürich, Switzerland.
Ruppert
S
S
Schaffner
W
W
Matthias
P
P
D000595:Amino Acid Sequence; D001402:B-Lymphocytes / Q000378:metabolism; D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D005796:Genes; D005801:Genes, Homeobox; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology
D014157:Transcription Factors