Euthyroid hyperthyroxinaemia due to endogenous antibodies to thyroxine and tri-iodothyronine. A case report.
A case of euthyroid hyperthyroxinaemia caused by auto-antibodies to thyroxine and tri-iodothyronine is presented. Gel filtration chromatography of the patient's serum showed increased binding of radio-labelled thyroxine analogue to a macromolecular component, which migrated in the gammaglobulin region on electrophoresis. Precipitation by protein A confirmed that this was an immunoglobulin. The importance of recognising this condition so that inappropriate therapy can be avoided is stressed.
Mulligan
G P
GP
Department of Chemical Pathology, University of Cape Town.
Davidson
J S
JS
Kaplan
H
H
Abrahamson
M J
MJ
D001323:Autoantibodies / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006981:Hyperthyroxinemia / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D013971:Thyrotoxicosis / Q000175:diagnosis; D013974:Thyroxine / Q000097:blood / Q000276:immunology*; D014284:Triiodothyronine / Q000097:blood / Q000276:immunology*
D001323:Autoantibodies; D014284:Triiodothyronine; D013974:Thyroxine