A syndrome resembling lymphomatoid granulomatosis in the dog.
Lymphomatoid granulomatosis (LYG) was diagnosed in seven dogs. Most of the affected dogs were young to middle-aged, and there was no breed or sex predilection. Basophilia was detected in six of the seven dogs. Radiographic abnormalities included lung lobe consolidation or pulmonary mass lesions, as well as abnormally large tracheobronchial lymph nodes. Histologic changes included angiocentric and angiodestructive pulmonary infiltrates characterized by large lymphoreticular and plasmacytoid cells as well as normal lymphocytes, eosinophils, and plasma cells. Five dogs were treated with combination chemotherapy, and three had a complete response to treatment.
Postorino
N C
NC
Comparative Oncology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins.
Wheeler
S L
SL
Park
R D
RD
Powers
B E
BE
Withrow
S J
SJ
D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use; D004283:Dog Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D005260:Female; D008168:Lung / Q000000981:diagnostic imaging; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008230:Lymphomatoid Granulomatosis / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D011859:Radiography; D013577:Syndrome / Q000662:veterinary
D003520:Cyclophosphamide; D011241:Prednisone