Multicentric reticulohistiocytosis in a child with sclerosing lesion of the leg. Immunohistopathologic studies and therapeutic trial with systemic cyclosporine.
Multicentric reticulohistiocytosis affecting a 13-year-old boy induced a sclerosing change of the leg. The cellular infiltrate comprising activated T lymphocytes and macrophages and human lymphocyte antigen (HLA)-DR expression by keratinocytes in lesional skin all suggest the involvement of cellular immune reactions. We administered systemic cyclosporine but could not obtain a favorable effect without a concomitant low dosage of prednisone.
Kuramoto
Y
Y
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
Iizawa
O
O
Aiba
S
S
Makino
Y
Y
Tagami
H
H
D000293:Adolescent; D000911:Antibodies, Monoclonal; D001706:Biopsy; D003524:Cyclosporins / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D007871:Leg Ulcer / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008206:Lymphatic Diseases / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*
D000911:Antibodies, Monoclonal; D003524:Cyclosporins; D006684:HLA-DR Antigens; D011241:Prednisone