T gamma lymphocytosis is clinically non-progressive but immunologically heterogeneous.
Immunological studies were performed with the expanded T gamma cells of five patients with T gamma lymphocytosis. All patients showed a stable clinical picture with persistent T gamma lymphocytosis and neutropenia, with or without recurrent infections. The expanded T gamma cells in the blood had the T1-3+4-8+11+M1- phenotype, with the exception of one patient whose cells lacked the T8 marker. The expanded T gamma cell population did not proliferate in response to T cell mitogens and did not show immunoregulatory activity on pokeweed mitogen driven immunoglobulin synthesis. In four of the five patients the T gamma cells had killer cell activity against IgG sensitized mouse mastocytoma cells. Taken together, these results and the data from the literature, it is concluded that T gamma lymphocytosis represents a spectrum of T cell expansions clearly distinct from clinically progressive mature T cell neoplasias.
Miedema
F
F
Terpstra
F G
FG
Smit
J W
JW
van der Veen
J P
JP
Melief
C J
CJ
D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000032:analysis; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008218:Lymphocytosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D008938:Mitosis; D010641:Phenotype; D011961:Receptors, Fc / Q000032:analysis; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D011961:Receptors, Fc