[Experiences at a peripheral hospital with the intracoronary administration of streptokinase and urokinase in acute heart infarct].
In 285 patients intracoronary fibrinolytic agents were administered 300 times during the acute phase of a myocardial infarction. The results and the complications of this therapy, as administered in a community hospital, did not differ from those obtained in a big randomized study performed by the Interuniversity Cardiological Institute of The Netherlands. Recanalization of a completely occluded coronary artery was obtained in 79% of the cases. Only 8.3% of the patients needed blood transfusion because of blood loss via the puncture in the femoral artery. No intracranial bleeding occurred. Actuarial total survival after 12 months was 90.5%. The incidence of recurrent myocardial infarction after successful intracoronary fibrinolytic therapy appears rather high; therefore, in some patient categories further therapy may be considered such as percutaneous transluminal coronary angioplasty or aortocoronary bypass surgery.
van Brussel
B L
BL
Hendriks
D
D
Relik-van Wely
L
L
el Gamal
M I
MI
Ernst
J M
JM
Plokker
H W
HW
D000208:Acute Disease; D003331:Coronary Vessels; D005069:Evaluation Studies as Topic; D005260:Female; D006764:Hospitals, Community; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D013300:Streptokinase / Q000008:administration & dosage*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
D013300:Streptokinase; D014568:Urokinase-Type Plasminogen Activator
Ervaringen in een perifeer ziekenhuis met de intracoronaire toediening van streptokinase en urokinase bij het acute hartinfarct.