title: Effects of the posterior hypophysis and ovary on pheromonal production in normal females and in the reproductive behavior of male rats treated with D,L-propranolol.
abstract: Posterior hypophysis homogenates of female rats stimulated with epinephrine subcutaneously contain a pheromonal factor that increments significantly the incidence of fertile coitus after having been placed in the oronasal groove of rats in proestro (69.2% fertile coitus vs. 36.6% of control). These same homogenates obtained from spayed rats increment reproductive activity even more (80.0% fertile coitus). The homogenates do not act by an intraperitoneal route. Male rats under the effect of high doses of D,L-propranolol reduce reproductive activity (21.2% fertile coitus). This effect is counteracted by posterior hypophysis homogenates from female rats stimulated with epinephrine, placed in the oronasal groove (72.2% fertile coitus). The homogenates of anterior hypophysis do not increase the reproductive capacity of rats in proestro, and do not modify the propranolol effects in male rats.
authors.affiliation: Department of Physiology, School of Medicine, University of Chile, Santiago.
authors.forename: J
authors.initials: J
authors.lastname: Zipper
authors.forename: M E
authors.initials: ME
authors.lastname: Bruzzone
authors.forename: V
authors.initials: V
authors.lastname: Trujillo
authors.forename: P
authors.initials: P
authors.lastname: Balboa
mesh_terms: D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D008297:Male; D010053:Ovary / Q000187:drug effects* / Q000502:physiology; D010675:Pheromones / Q000096:biosynthesis*; D010904:Pituitary Gland, Posterior / Q000187:drug effects* / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012724:Sex Attractants / Q000096:biosynthesis*; D012726:Sexual Behavior, Animal / Q000187:drug effects*
chemical_list: D010675:Pheromones; D012724:Sex Attractants; D011433:Propranolol; D004837:Epinephrine