[Absence of the antihypertensive effect of chronic treatment with prazosin in the spontaneously hypertensive rat (SHR) and their offspring].
Seven consanguine monogamous SHR couples (G 1) were treated from their 5th to their 39th week of age with prazosin, 100 micrograms/kg/day i.p. Male rats were treated without interruption. Treatment was withheld in female rats from delivery to weaning. They were compared to seven similar SHR couples who were only daily i.p. injected with the same volume of solvent. Second (G 2) generation rats (untreated were studied. In G 1 female rats only, prazosin induced a transient decrease in systolic blood pressure (SBP), 6 hours after the injection, at 25 weeks of age. SBP, heart weight/body weight ratio and plasma renin activity remained unchanged at 39 weeks of age. Gestational parameters were not changed by the treatment, and no parameter was changed in G 2 rats. A previous study in the same conditions with another alpha 1-adrenoreceptor blocking agent, nicergoline, showed an inhibition of hypertension development in G 1 rats together with a preventive effect on untreated G 2 SHR (Moore et al., 1983). Thus prazosin failed to produce similar antihypertensive effects both in the treated rats and in their offspring and one can therefore conclude that nicergoline's effects were not only due to alpha 1-adrenoceptor blockade.
Chadelaud
M
M
Moore
N
N
Berland
C
C
Saligaut
C
C
Daoust
M
M
Chrétien
P
P
Boismare
F
F
D000375:Aging; D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight; D006332:Cardiomegaly / Q000503:physiopathology; D005260:Female; D008297:Male; D011224:Prazosin / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D012083:Renin / Q000097:blood; D012098:Reproduction / Q000187:drug effects; D013997:Time Factors
D000959:Antihypertensive Agents; D012083:Renin; D011224:Prazosin
Absence d'effet antihypertenseur d'un traitement chronique par la prazosine chez le rat spontanément hypertendu (SHR) et sa descendance.