title: The accuracy of volumetric measurement of high-grade gliomas.
abstract: To assess the accuracy of volumetric measurement of high-grade intracranial gliomas by computed tomography (CT), the scans of 26 patients were studied retrospectively. Twenty patients had only pre-treatment scans while six had scans both before and after chemotherapeutic treatment. Tumour volumes were measured separately by two observers, each on two occasions. A significant intraobserver variation in volumetric measurement was encountered, as well as a systematic variation between the observers; one radiologist consistently reading higher than the other. The after treatment readings were more variable than the pre-treatment readings, and most changes in tumour volume following treatment were obscured by the intra-observer variation. This study provides further evidence of the limitations of volumetric measurement as a means of assessing the response of high-grade gliomas to treatment.
authors.affiliation: Department of Radiology, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: R A
authors.initials: RA
authors.lastname: Chisholm
authors.forename: S
authors.initials: S
authors.lastname: Stenning
authors.forename: T D
authors.initials: TD
authors.lastname: Hawkins
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D005910:Glioma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D006801:Humans; D012189:Retrospective Studies; D013997:Time Factors; D014057:Tomography, X-Ray Computed