Comparative study on cerebrovascular injuries by three chlorophenoxyacetic acids (2,4-D, 2,4,5-T and MCPA).
At toxic doses in rats, 2,4-dichlorophenoxyacetic acid (2,4-D) and 2-methyl-4-chlorophenoxyacetic acid (MCPA) caused injuries in blood vessels in the brain. 2. 2,4-D caused extravasations of the circulating Evans blue-albumin complex also in the spinal cord. 3. By contrast, potency in damaging cerebral vessels was almost non-existent with 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). 4. None of the three chlorophenoxyacetic acids caused such cerebrovascular injuries in mice, guinea pigs, Syrian hamsters, rabbits and chickens.
Elo
H A
HA
Department of Pharmacology and Toxicology, University of Kuopio, Finland.
Hervonen
H
H
Ylitalo
P
P
D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000633:toxicity*; D015084:2,4-Dichlorophenoxyacetic Acid / Q000633:toxicity*; D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000633:toxicity*; D000818:Animals; D001921:Brain / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000139:chemically induced* / Q000473:pathology; D002645:Chickens; D006224:Cricetinae; D005260:Female; D006016:Glycolates / Q000633:toxicity*; D006168:Guinea Pigs; D006540:Herbicides / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D008647:Mesocricetus; D051379:Mice; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013116:Spinal Cord / Q000473:pathology
D006016:Glycolates; D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid; D015085:2,4,5-Trichlorophenoxyacetic Acid; D008456:2-Methyl-4-chlorophenoxyacetic Acid