High-performance liquid chromatographic determination of trimethoprim in serum.
A procedure for determining trimethoprim in serum is reported. It employs the same high-performance liquid chromatographic system described previously for measurement of anticonvulsants, barbiturates, theophylline, caffeine, acetaminophen, and chloramphenicol in serum. The sample preparation for trimethoprim is nearly identical. As a method extension, quantitation of serum trimethoprim on clinical specimens can be easily accommodated as required.
Meatherall
R
R
Department of Clinical Biochemistry, St. Boniface General Hospital, Winnipeg, Manitoba, Canada.
D002851:Chromatography, High Pressure Liquid; D006801:Humans; D014295:Trimethoprim / Q000031:analogs & derivatives / Q000097:blood* / Q000378:metabolism
D014295:Trimethoprim