Trigeminovascular fibers increase blood flow in cortical gray matter by axon reflex-like mechanisms during acute severe hypertension or seizures.
Cerebral blood flow was measured and compared in 10 symmetrical brain regions following unilateral trigeminal ganglionectomy (n = 13), sham operation (n = 6), or trigeminal root section (rhizotomy) (n = 8) in cats. Multiple determinations were obtained in anesthetized and paralyzed animals using radiolabeled microspheres during (i) normocapnia-normotension, (ii) hypercapnia (5% CO2/95% room air), (iii) angiotensin-induced acute severe hypertension (190 greater than mean arterial blood pressure less than 210 mmHg), or (iv) bicuculline-induced seizures. Flow was symmetrical in all brain regions at rest and during increases induced by hypercapnia in the three groups. During severe hypertension or seizures, marked elevations developed bilaterally (approximately 93% and approximately 130%, respectively). In ganglionectomized animals, increases due to hypertension or seizures were attenuated by 28-32% on the denervated side within cortical gray matter regions corresponding to the anterior, middle, and posterior cerebral arteries. Flow was symmetrical within all brain regions in sham-operated animals and in the rhizotomy group, despite comparable increases in regional cerebral blood flow induced by angiotensin. Hence, the trigeminal nerve mediates blood flow adaptations during severe hypertension and seizures. Furthermore, since trigeminal cell bodies and peripheral axons are destroyed or degenerate following ganglionectomy but not following rhizotomy, local "axon reflex-like" mechanisms mediate these increases in cerebral blood flow.
Sakas
D E
DE
Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston 02114.
Moskowitz
M A
MA
Wei
E P
EP
Kontos
H A
HA
Kano
M
M
Ogilvy
C S
CS
D000804:Angiotensin II; D000818:Animals; D001369:Axons / Q000502:physiology*; D001640:Bicuculline; D001794:Blood Pressure; D002415:Cats; D002560:Cerebrovascular Circulation; D005260:Female; D015171:Ganglionectomy; D006935:Hypercapnia / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009928:Organ Specificity; D010487:Periaqueductal Gray / Q000098:blood supply* / Q000503:physiopathology; D012016:Reference Values; D012018:Reflex; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D014276:Trigeminal Nerve / Q000502:physiology / Q000503:physiopathology*
D000804:Angiotensin II; D001640:Bicuculline