title: Effect of exercise training on plasma cholesterol and cholesterol kinetics in adult female rats.
abstract: Adult female rats fed laboratory chow of low cholesterol content were trained by swimming for 77 days. Plasma cholesterol concentration decreased 38% compared to sedentary controls. Whole body cholesterol metabolism was studied by injection of [14C]cholesterol tracer and determination of the plasma cholesterol-specific activity during the last 49 days of the experiment. The rate constant for elimination of cholesterol from the body was 31% higher in swimming than in sedentary animals, and the size of the rapidly-exchanging cholesterol pool was 28% smaller. These results suggest that enhanced cholesterol excretion or catabolism accompanies exercise training in the rat.
authors.affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: R E
authors.initials: RE
authors.lastname: Ostlund
authors.forename: M
authors.initials: M
authors.lastname: Reaban
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics; D005260:Female; D010805:Physical Conditioning, Animal; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002784:Cholesterol