title: Absorption of dihydrotestosterone (DHT) after its intramuscular administration.
abstract: In order to produce a sustained release system for natural androgens, two groups of six hypogonadal males received intramuscular (IM) 40 mg crystalline dihydrotestosterone (DHT), either with particle size of less than 50 microns (DHT-M) or between 100 and 150 microns (DHT-C). Serum DHT was analyzed through 51 days of follow-up. In the DHT-M group, serum DHT was above pretreatment values for 17 days, whereas in the DHT-C group, this period was extended over 50 days. The area under the serum concentration-time curve and the half-life of absorption calculated for the DHT-C group were greater than those obtained for the DHT-M group (55.1 ng/day/ml and 21 days vs. 14.5 ng/day/ml and 6 days; P less than 0.01). The authors conclude that DHT injection appears to be an effective and convenient technique for restoring serum physiologic DHT levels. This approach is suitable for long-term substitution therapy.
authors.affiliation: Department of Reproductive Biology, Instituto Nacional de la Nutrición Salvador Zubirán, Tlalpan, México, D.F.
authors.forename: V
authors.initials: V
authors.lastname: Díaz-Sánchez
authors.forename: F
authors.initials: F
authors.lastname: Larrea
authors.forename: A
authors.initials: A
authors.lastname: Ulloa-Aguirre
authors.forename: J
authors.initials: J
authors.lastname: Garza-Flores
authors.forename: E
authors.initials: E
authors.lastname: Richards
authors.forename: F
authors.initials: F
authors.lastname: Veayra
mesh_terms: D000042:Absorption; D000328:Adult; D003692:Delayed-Action Preparations; D013196:Dihydrotestosterone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy*; D007273:Injections, Intramuscular; D008297:Male; D011863:Radioimmunoassay
chemical_list: D003692:Delayed-Action Preparations; D013196:Dihydrotestosterone