title: The adrenocortical function of alloxan-induced diabetic rats.
abstract: The purpose of this study is to investigate the adrenocortical function of alloxan-induced diabetic rats. Male rats of Wistar strain, weighing 200-250 gm were used. The results indicated that the adrenocortical response to stress and exogenous corticotropin (ACTH1-24) is decreased during the early diabetic stages (up to 6 days). Evidence from in vivo and in vitro studies shows that the depression is caused by the toxicity of alloxan on the adrenal cortex cells and not by the sudden rise of blood glucose levels. Streptozotocin (another diabetogen) has the same effect as alloxan on adrenal cortex cells.
authors.forename: J H
authors.initials: JH
authors.lastname: Lin
authors.forename: M H
authors.initials: MH
authors.lastname: Shieh
authors.forename: L S
authors.initials: LS
authors.lastname: Wu
authors.forename: W H
authors.initials: WH
authors.lastname: Lin
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects / Q000503:physiopathology*; D000496:Alloxan / Q000633:toxicity; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003345:Corticosterone / Q000096:biosynthesis / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000503:physiopathology*; D005947:Glucose / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin / Q000633:toxicity; D013312:Stress, Physiological / Q000503:physiopathology
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013311:Streptozocin; D000496:Alloxan; D005947:Glucose; D003345:Corticosterone