title: A light and electron microscopical study of B-50 (GAP-43) in human intramuscular nerve and neuromuscular junctions during development.
abstract: The growth associated protein B-50 (GAP-43) is demonstrated in human intramuscular nerves and neuromuscular junctions by light microscopy and electron microscopy. Nearly all fetal endplates are shown to be immunoreactive for B-50. The percentage of B-50 positive endplates decreases significantly during the peri- and neonatal period, but in children and adults a low percentage of B-50 positive endplates remains present. These data indicate that also in the human peripheral nervous system the expression of B-50 is developmentally regulated.
authors.affiliation: Laboratory for neuromuscular diseases, University Hospital, Utrecht, The Netherlands.
authors.forename: L F
authors.initials: LF
authors.lastname: Hesselmans
authors.forename: F G
authors.initials: FG
authors.lastname: Jennekens
authors.forename: C J
authors.initials: CJ
authors.lastname: van den Oord
authors.forename: A B
authors.initials: AB
authors.lastname: Oestreicher
authors.forename: H
authors.initials: H
authors.lastname: Veldman
authors.forename: W H
authors.initials: WH
authors.lastname: Gispen
mesh_terms: D000328:Adult; D000375:Aging / Q000378:metabolism*; D000911:Antibodies, Monoclonal; D002648:Child; D005333:Fetus / Q000378:metabolism*; D019922:GAP-43 Protein; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D008854:Microscopy, Electron; D024510:Muscle Development; D009132:Muscles / Q000294:innervation* / Q000648:ultrastructure; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009469:Neuromuscular Junction / Q000378:metabolism* / Q000502:physiology / Q000648:ultrastructure
chemical_list: D000911:Antibodies, Monoclonal; D019922:GAP-43 Protein; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins