Effects of chronic experimental streptozotocin-induced diabetes on the noradrenergic and peptidergic innervation of the rat alimentary tract.
Immunohistologic localization of tyrosine hydroxylase (TOH), dopamine-beta-hydroxylase (DBH) and selected neuropeptides (vasoactive intestinal polypeptide, gastrin-releasing peptide (GRP)/bombesin, substance P, Leu-enkephalin, Met-enkephalin, dynorphin B, neuropeptide Y (NPY), somatostatin) was used to investigate the innervation of the small bowel in a rat model of diabetic autonomic neuropathy. Paravascular mesenteric nerves (extrinsic) and intramural nerves of chronically (12-18 month) diabetic rats were characterized by the presence of numerous, markedly swollen dystrophic axons which stained intensely for TOH and DBH. The peptidergic complement of axons, however, showed no evidence of comparable dystrophic axonopathy.
Schmidt
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RE
Washington University School of Medicine, Department of Pathology, St. Louis, MO 63110.
Plurad
D A
DA
Roth
K A
KA
D000818:Animals; D001341:Autonomic Nervous System / Q000503:physiopathology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D007421:Intestine, Small / Q000294:innervation*; D009197:Myenteric Plexus / Q000503:physiopathology; D009479:Neuropeptides / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D009479:Neuropeptides; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase