title: Effect of dietary alpha-linolenate/linoleate balance on mean survival time, incidence of stroke and blood pressure of spontaneously hypertensive rats.
abstract: Following the suckling period, stroke-prone spontaneously hypertensive rats (SHR-SP) were fed semi-purified diets supplemented either with safflower seed oil (rich in linoleic acid) or with perilla seed oil (rich in alpha-linolenic acid). The mean survival time of male SHR-SP fed the perilla diet was longer than that fed the safflower diet by 17% (p less than 0.001) while the difference was 15% in female SHR-SP (p less than 0.05). The mean survival times of female SHR-SP were more than 40% longer than those of male SHR-SP in both dietary groups. Post-mortem examinations of brains revealed apoplexy-related symptoms as the major cause of the death in both dietary groups. The systolic blood pressure was lower by ca. 10% (21 mmHg) in the perilla group than in both the safflower group and conventional diet group. The eicosapentaenoate (20:5 n-3)/arachidonate (20:4 n-6) ratio of platelet phospholipids in spontaneously hypertensive rat (SHR), a measure of platelet aggregability, was much higher in the perilla group than in the safflower group. Thus, increasing the dietary alpha-linolenate/linoleate ratio resulted in an increased mean survival time of SHR-SP rats, possibly by lowering blood pressure and platelet aggregability.
authors.affiliation: Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shimokawa
authors.forename: A
authors.initials: A
authors.lastname: Moriuchi
authors.forename: T
authors.initials: T
authors.lastname: Hori
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: Y
authors.initials: Y
authors.lastname: Naito
authors.forename: H
authors.initials: H
authors.lastname: Kabasawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nagae
authors.forename: M
authors.initials: M
authors.lastname: Matsubara
authors.forename: H
authors.initials: H
authors.lastname: Okuyama
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000503:physiopathology* / Q000517:prevention & control; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology*; D008042:Linolenic Acids / Q000494:pharmacology*; D008136:Longevity / Q000187:drug effects*; D008297:Male; D010938:Plant Oils / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012016:Reference Values; D012450:Safflower Oil / Q000494:pharmacology*; D012737:Sex Factors; D017962:alpha-Linolenic Acid
chemical_list: D004041:Dietary Fats; D008041:Linoleic Acids; D008042:Linolenic Acids; D010938:Plant Oils; D017962:alpha-Linolenic Acid; C058216:perilla seed oil; D012450:Safflower Oil; D019787:Linoleic Acid