Effect of hematoporphyrin derivative photoradiation therapy on survival in the rat 9L gliosarcoma brain-tumor model.
Intracerebral tumors were produced in 99 rats by stereotaxic implantation of 9L gliosarcoma brain-tumor cells. Hematoporphyrin derivative (HPD), 10 or 20 mg/kg, was administered as an intravenous bolus 24 or 48 hours before irradiation of the tumor region with light from an argon pumped-dye laser (632 nm). Laser light, at a dose of 30, 60, or 200 joules/sq cm, was delivered through a craniectomy 10 or 13 days after tumor implantation. Survival times were significantly prolonged in rats exposed to laser light at a dose of 200 joules/sq cm 24 hours after administration of HPD, 20 mg/kg.
Boggan
J E
JE
Bolger
C
C
Edwards
M S
MS
D000818:Animals; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D005910:Glioma / Q000401:mortality / Q000532:radiotherapy*; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D006415:Hematoporphyrins; D017324:Hematoporphyrin Derivative