Effects of iron deficiency on metallothionein-I concentrations in blood and tissues of rats.
The effects of iron deficiency and of restriction of food intake on blood and tissue metallothionein-I (MT-I) concentrations in rats were investigated. Compared to ad libitum fed controls, MT-I concentrations in the blood cells of the iron-deficient rats were higher, whereas concentrations in pair-fed control rats were lower. Iron deficiency also increased MT-I concentrations in the bone marrow but concentrations in the liver were unchanged and those in the kidneys were reduced. The MT-I in the blood cells was associated mainly with the lighter cell fractions which were rich in reticulocytes. It is suggested that concentrations of MT-I in blood cells reflect erythropoietic activity.
Robertson
A
A
Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom.
Morrison
J N
JN
Wood
A M
AM
Bremner
I
I
D000747:Anemia, Hypochromic / Q000378:metabolism*; D000818:Animals; D001773:Blood Cells / Q000378:metabolism; D001835:Body Weight; D001853:Bone Marrow / Q000378:metabolism; D004032:Diet; D004435:Eating; D007501:Iron / Q000008:administration & dosage; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008668:Metallothionein / Q000097:blood / Q000378:metabolism*; D051381:Rats
D008668:Metallothionein; D007501:Iron