D-dimer levels in blood salvage for autotransfusion.
Autotransfusion of operatively salvaged blood is an increasingly attractive and used practice. The fear of precipitating a coagulopathy, however, has retarded the acceptance of autotransfusions and the efficiency and convenience of banked homologous blood has proved too competitive in recent years. The risk of transmitting diseases with bank homologous blood has seen a resurgence in the development of autotransfusion. The current alternatives to pre-operative autologous banking or dilution are the reinfusing of filtered salvaged blood, and of blood which has been further processed by washing which involves the extra cost of time, personnel and equipment. Washing removes possible harmful products, but also removes coagulation factors. D-Dimer levels were estimated by monoclonal antibody techniques in salvaged blood before and after washing in 10 patients undergoing aortic surgery and in 10 u of homologous banked blood. The D-Dimer levels in the unwashed blood were increased 85 times, but were normal in the washed blood. D-Dimers are an indication of activation of the coagulation and fibrinolytic systems and the presence of fibrin degradation products.
Lawrence-Brown
M M
MM
Vascular Surgery Unit, Royal Perth Hospital, Western Australia.
Couch
C
C
Halliday
M
M
Hellings
M
M
Barr
A
A
Marshall
L
L
D001011:Aorta / Q000601:surgery; D001804:Blood Transfusion, Autologous / Q000379:methods; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans
D005338:Fibrin Fibrinogen Degradation Products; D006454:Hemoglobins; C036309:fibrin fragment D