Pathogenesis of urinary tract infections--amoxicillin induces genital Escherichia coli colonization.
The aim of this study was to examine whether a vaginal Escherichia coli colonization, mimicking the one seen in UTI-prone females, could be induced by amoxicillin administration. In adult cynomolgus monkeys, who carry the alpha-Gal-1-4-beta-Gal receptor for P-fimbriae, we have investigated the ability of a clinical isolate of P-fimbriated E. coli to colonize the mucous membranes of the genital tract. When the vagina was washed with a suspension of the P-fimbriated strain, a persistent colonization was obtained in only 17% (4/24) of the experiments. When such colonization attempts were performed during vaginal amoxicillin administration, a persistent and heavy colonization of the vagina occurred in 5/5 attempts. The findings do not contradict our hypothesis that antibiotics given to UTI-prone females may facilitate the establishment of the abnormal colonization of the genital tract.
Herthelius
B M
BM
Hedström
K G
KG
Möllby
R
R
Nord
C E
CE
Pettersson
L
L
Winberg
J
J
D000282:Administration, Intravaginal; D000658:Amoxicillin / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D015169:Colony Count, Microbial; D004926:Escherichia coli / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000209:etiology*; D005260:Female; D010861:Fimbriae, Bacterial; D006863:Hydrogen-Ion Concentration; D008252:Macaca fascicularis; D014552:Urinary Tract Infections / Q000209:etiology*; D014621:Vagina / Q000187:drug effects / Q000382:microbiology*
D000658:Amoxicillin