title: Chronotropic and inotropic supports are both required to increase cardiac output early after corrective operations for tetralogy of Fallot.
abstract: To assess the respective roles of chonotropism, inotropism, and afterload reduction in increasing cardiac index early after corrective operations for tetralogy of Fallot, we measured vascular pressures and cardiac output and evaluated left ventricular dimension changes before and after a 35% rise in heart rate over baseline. This rise was induced by atrial pacing with intact atrioventricular conduction, isoproterenol, or atrial pacing together with dobutamine. With atrial pacing, left ventricular end-diastolic diameter decreased (38.7 +/- 4.3 to 34.2 +/- 5.6 mm, p less than 0.05), the shortening fraction (ratio of the difference between left ventricular end-diastolic and end-systolic diameters to left ventricular end-diastolic diameter) remained constant, and stroke volume index was reduced (28.8 +/- 4.5 to 19.7 +/- 4.6 ml/m2, p less than 0.05). As a result, cardiac index was left unchanged. When dobutamine was added as supplemental inotropic support, left ventricular end-diastolic diameter remained constant, shortening fraction increased (30% +/- 5.4% to 36% +/- 3.3%, p less than 0.05), and cardiac index rose significantly (3.04 +/- 0.61 to 4.18 +/- 0.85 L/min/m2, p less than 0.05). Heart rate acceleration with isoproterenol, combining chronotropism, positive inotropic support, and afterload reduction, slightly increased left ventricular end-diastolic diameter, significantly raised shortening fraction, and markedly enhanced cardiac index (3.03 +/- 0.55 to 4.9 +/- 1.09 L/min/m2). Atrial pacing with intact atrioventricular conduction, as an isolated chronotropic stimulus, is not suited to increase cardiac index early after operations for tetralogy of Fallot unless additional inotropic support is simultaneously provided.
authors.affiliation: Department of Pediatrics and Genetics, Clinique Universitaire de Pédiatrie, Hôpital Cantonal, Geneva, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Berner
authors.forename: I
authors.initials: I
authors.lastname: Oberhänsli
authors.forename: J C
authors.initials: JC
authors.lastname: Rouge
authors.forename: C
authors.initials: C
authors.lastname: Jaccard
authors.forename: B
authors.initials: B
authors.lastname: Friedli
mesh_terms: D000293:Adolescent; D002302:Cardiac Output / Q000187:drug effects; D002304:Cardiac Pacing, Artificial; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004280:Dobutamine / Q000627:therapeutic use*; D004452:Echocardiography; D006339:Heart Rate; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007545:Isoproterenol / Q000627:therapeutic use*; D011182:Postoperative Care; D013771:Tetralogy of Fallot / Q000601:surgery*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D004280:Dobutamine; D007545:Isoproterenol