title: Participation of reticuloendothelial system in the pathogenesis of experimental amyotrophic leukospongiosis.
abstract: Spleen and peripheral blood lymphocytes were found to play an important role in the pathogenesis of amyotrophic leukospongiosis (AL). At early stage of AL they are the sites of reproduction and accumulation of an unconventional virus; they also provide its dissemination in the body of infected animals. In lymph nodes and visceral organs the AL pathogen was detected in much lower quantities and only in the period of clinically manifest disease. The level of the complement was significantly decreased in the serum of animals with experimental AL. This decrease correlated with the development of clinico-morphological lesions and reached its maximum at the terminal stage of disease.
authors.affiliation: Laboratory of Slow Infections of Human Central Nervous System Caused by Unconventional Viruses, Ministry of Health of Byelorussian Soviet Socialist Republic, Minsk.
authors.forename: N D
authors.initials: ND
authors.lastname: Kolomiets
authors.forename: V I
authors.initials: VI
authors.lastname: Votyakov
authors.forename: A G
authors.initials: AG
authors.lastname: Kolomiets
mesh_terms: D000818:Animals; D003165:Complement System Proteins / Q000032:analysis; D006168:Guinea Pigs; D006801:Humans; D008198:Lymph Nodes / Q000382:microbiology; D008214:Lymphocytes / Q000382:microbiology; D012157:Mononuclear Phagocyte System / Q000382:microbiology*; D009420:Nervous System / Q000382:microbiology*; D012897:Slow Virus Diseases / Q000382:microbiology*; D013154:Spleen / Q000382:microbiology; D013997:Time Factors
chemical_list: D003165:Complement System Proteins