Administration of L-2-oxothiazolidine-4-carboxylate increases glutathione levels in rat brain.
Sterile L-2-oxothiazolidine-4-carboxylate, given as a neutral 100 mmol solution at a dose of 8 mmol/kg subcutaneously, caused an increase in total glutathione concentration in the brain of treated rats. This finding could be important in understanding the role of glutathione in the central nervous system.
Mesina
J E
JE
Department of Neurology, Henry Ford Hospital, Detroit, MI 48202.
Page
R H
RH
Hetzel
F W
FW
Chopp
M
M
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D008297:Male; D011761:Pyrrolidonecarboxylic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D013844:Thiazoles / Q000494:pharmacology*; D053778:Thiazolidines
D013844:Thiazoles; D053778:Thiazolidines; D005978:Glutathione; D011761:Pyrrolidonecarboxylic Acid; C029536:2-oxothiazolidine-4-carboxylic acid