title: Evaluation of two new insect growth regulators against mosquitoes in the laboratory.
abstract: Biological activity of two new IGRs was studied under laboratory conditions against 2nd- and 4th-instar larvae and pupae of Anopheles quadrimaculatus, Aedes aegypti and Culex tarsalis. The IGR S-21149, an oxime [0-(2-(4'-Phenoxyphenoxy)ethyl propionaldoxime], produced an overall mortality or inhibition of emergence of 95% (when 4th instar treated) at 0.0047, 0.0013 and 0.00041 mg/liter in the three species, respectively. The EI95 values for the second IGR S-31183, a pyridine compound, [1-(4'-Phenoxyphenoxy)-2-(2'pyridyloxy) propane] were 0.017, 0.0026 and 0.00032 mg/liter for the three species, respectively. Both materials in general were less active against 2nd than 4th-instar larvae, except that the 2nd- and 4th instars of An. quadrimaculatus were equally susceptible. Pupae treated at up to 0.1 mg/liter showed no mortality in the pupal or the ensuing adult stages.
authors.affiliation: Department of Entomology, University of California, Riverside, CA 92521.
authors.forename: J G
authors.initials: JG
authors.lastname: Estrada
authors.forename: M S
authors.initials: MS
authors.lastname: Mulla
mesh_terms: D000330:Aedes / Q000187:drug effects / Q000254:growth & development; D000818:Animals; D000852:Anopheles / Q000187:drug effects / Q000254:growth & development; D003465:Culex / Q000187:drug effects / Q000254:growth & development; D009033:Culicidae / Q000187:drug effects* / Q000254:growth & development; D007605:Juvenile Hormones / Q000138:chemical synthesis / Q000494:pharmacology; D010091:Oximes / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*
chemical_list: D007605:Juvenile Hormones; D010091:Oximes; D011725:Pyridines; C055613:pyriproxyfen; C055615:O-(2-(4-phenoxyphenoxy)ethyl)propionaldoxime