Investigations on the development and regression of corticosteroid-induced thinning of the skin in various parts of the human body during and after topical application of amcinonide.
In 15 subjects 6 different parts of the body were treated with the potent topical corticosteroid (CS) amcinonide once a day for 21 days. The skin thickness of the treated areas was measured sonographically at intervals of 2 days. After completion of the CS application the regression of the CS-induced reduction in skin thickness was measured for a further 14 days. A clear thinning of the skin could be measured after only 4 days and continued up to the 21st day of treatment. This thinning regressed completely in all areas after 10-12 days. The thinning and regression curves were very similar for all body areas. Differences in intensity of thinning were evident. No tachyphylaxis was detected.
Lubach
D
D
Department of Dermatology (Hautklinik Linden), Medizinische Hochschule Hannover, FRG.
Grüter
H
H
Behl
M
M
Nagel
C
C
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects*; D014221:Triamcinolone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology
D014221:Triamcinolone; C012716:amcinonide