title: Adjuvant oral alkylating chemotherapy in patients with stage I epithelial ovarian cancer.
abstract: From November 1973 to May 1986, 50 patients with Stage I epithelial ovarian cancer were treated at the University of Kentucky Medical Center (Lexington, KY) with oral Alkeran (melphalan) chemotherapy after primary surgery. Twenty-two patients had Grade 1 tumors, 23 patients had Grade 2 tumors, and five patients had Grade 3 tumors. Patients with ovarian tumors of borderline malignancy were excluded from this study. Twenty-eight patients received from six to 11 courses of chemotherapy and 22 patients completed 12 courses of chemotherapy. Chemotherapy was well tolerated and no patient died of chemotherapy-related complications. Thirty-eight patients underwent second-look laparotomy died of disease 41 months after diagnosis and one patient died with no evidence of disease 6 months after treatment. The actuarial survival of the total group of patients was 98% at 2 years and 94% at 5 years. Fewer than 12 months of chemotherapy may be necessary to obtain long-term survival in these patients.
authors.affiliation: Department of Obstetrics and Gynecology, University of Kentucky Medical Center, Lexington 40536.
authors.forename: H H
authors.initials: HH
authors.lastname: Gallion
authors.forename: J R
authors.initials: JR
authors.lastname: van Nagell
authors.forename: E S
authors.initials: ES
authors.lastname: Donaldson
authors.forename: R V
authors.initials: RV
authors.lastname: Higgins
authors.forename: D E
authors.initials: DE
authors.lastname: Powell
authors.forename: R J
authors.initials: RJ
authors.lastname: Kryscio
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000477:Alkylating Agents / Q000008:administration & dosage* / Q000009:adverse effects; D003131:Combined Modality Therapy; D003536:Cystadenocarcinoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D010298:Parity; D012086:Reoperation
chemical_list: D000477:Alkylating Agents