[Clinical evaluation of drug interactions of cyclosporin].
Cyclosporin is a nephrotoxic immunosuppressant metabolized in the liver and requiring drug monitoring. Numerous pharmacokinetic and pharmacodynamic drug interactions have occurred with this compound. Some of them are well substantiated while others are merely suspected. The major interactions must definitely be prevented of corrected, whereas the others need no more than careful drug monitoring.
Billaud
E M
EM
Service de Pharmacologie clinique, Hôpital Broussais, Paris.
Kreft-Jais
C
C
De la Tour du Pin
F
F
Alexandre
J M
JM
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D003524:Cyclosporins / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008775:Methylprednisolone / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002121:Calcium Channel Blockers; D003524:Cyclosporins; D006635:Histamine H2 Antagonists; D008775:Methylprednisolone
Evaluation clinique des interactions médicamenteuses de la ciclosporine.