Polyamines are sufficient to drive the transport of the precursor of ornithine carbamoyltransferase into rat liver mitochondria: possible effect on mitochondrial membranes.
The polyamines spermidine, spermine and putrescine, by themselves, at physiological concentrations, induce the transport of the precursor of ornithine carbamoyltransferase into isolated rat liver mitochondria. The presence of polyamines in the transport medium results in the approach of both mitochondrial membranes, suggesting a possible role of these molecules in the transport of the precursor of ornithine carbamoyltransferase into mitochondria, by the formation and/or stabilization of mitochondrial structures involved in the transport system.
Marcote
M J
MJ
Instituto de Investigacioneś Citológicas, Caja de Ahorros de Valencia, Spain.
González-Bosch
C
C
Miralles
V J
VJ
Hernández-Yago
J
J
Grisolía
S
S
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D004792:Enzyme Precursors / Q000235:genetics*; D007425:Intracellular Membranes / Q000502:physiology*; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000201:enzymology* / Q000648:ultrastructure; D009954:Ornithine Carbamoyltransferase / Q000235:genetics*; D011499:Protein Processing, Post-Translational / Q000187:drug effects*; D011700:Putrescine / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D013095:Spermidine / Q000494:pharmacology*; D013096:Spermine / Q000494:pharmacology*
D004792:Enzyme Precursors; D012333:RNA, Messenger; D013096:Spermine; D009954:Ornithine Carbamoyltransferase; D013095:Spermidine; D011700:Putrescine