Polyamine levels during Xenopus laevis oogenesis: a role in oocyte competence to meiotic resumption.
The results presented here show that a decrease in the concentration of total polyamines, due to a decrease in putrescine and spermine, occurs during oogenesis in Xenopus laevis. The microinjection of spermine or spermidine decreases the hormonal responsiveness (maturation) of the fully-grown oocytes. This effect is synergistic with that already described for the microinjection of casein kinase II (Mulner-Lorillon, O. et al. (1987) Eur. J. Biochem. 171, 107-117), a polyamine dependent enzyme. Therefore a decrease in polyamine concentration, via its effect on endogeneous casein kinase II, could constitute one of the molecular changes required for the acquisition of competence to mature.
Osborne
H B
HB
Laboratoire de Biologie et Génétique du Développement, CNRS URA 95, Université de Rennes I, France.
Mulner-Lorillon
O
O
Marot
J
J
Belle
R
R
D000818:Animals; D008540:Meiosis; D009865:Oocytes / Q000502:physiology*; D009866:Oogenesis; D009952:Ornithine / Q000378:metabolism; D009955:Ornithine Decarboxylase / Q000378:metabolism; D011073:Polyamines / Q000502:physiology*; D011374:Progesterone / Q000494:pharmacology; D014982:Xenopus laevis
D011073:Polyamines; D011374:Progesterone; D009952:Ornithine; D009955:Ornithine Decarboxylase