[No correlation between suppressor cell function and disease activity in natural history studies of patients with systemic lupus erythematosus].
In ten patients with systemic lupus erythematosus lymphocyte suppressor cell function was repeatedly monitored over a period of nine months. The method used is based on the finding that in vitro addition of ConA to PWM-stimulated lymphocytes activates suppressor T cells which in turn inhibit immunoglobulin synthesis. Nine of ten SLE patients exhibited significant impairment of IgG suppression but no correlation was found between the outcome of the IgG suppressor cell assay and disease activity or the treatment protocol applied.
Rautenstrauch
H
H
Frank
F
F
Saal
J G
JG
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000276:immunology*; D008213:Lymphocyte Activation; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
D000305:Adrenal Cortex Hormones; D007074:Immunoglobulin G
Keine Korrelation von Suppressorzellaktivität und Krankheitsaktivität in Verlaufsuntersuchungen von Patienten mit systemischem Lupus erythematodes.