A tumor growth inhibitory factor and a tumor growth promoting factor isolated from unfertilized ova of shad (Alosa sapidissima).
In the present study, a cytostatic tumor growth inhibitory peptide and a tumor growth promoting peptide with molecular weights of 20,000-30,000 Da have been identified in the supernatant fraction of unfertilized ova from Shad. The factors can be separated by gel chromatography, thus indicating that the factors are individual molecules. Both of the factors are nondialyzable, heat stable, and resistant to trypsin digestion and periodate oxidation.
Sheid
B
B
Department of Pharmacology, State University of New York, Brooklyn 11203.
Prat
J C
JC
Gaetjens
E
E
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000502:physiology*; D001419:Bacteria / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005399:Fishes / Q000378:metabolism*; D006131:Growth Inhibitors / Q000302:isolation & purification / Q000502:physiology*; D006133:Growth Substances / Q000302:isolation & purification / Q000502:physiology*; D007939:Leukemia L1210 / Q000188:drug therapy / Q000473:pathology*; D051379:Mice; D010063:Ovum / Q000032:analysis*
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D006133:Growth Substances