RFLPs and linkage relationships of the human laminin B2 gene.
RFLPs for laminin B2 (LAMB2) are reported. These RFLPs were used to study the linkage relationships of LAMB2 to four other genes on lq: Duffy (FY), renin (REN), decay accelerating factor (DAF), and complement receptor 2 (CR2). Multipoint linkage analysis placed LAMB2 between FY and the cluster including REN, DAF, and CR2. This provides a useful bridging polymorphic marker on lq and establishes significant linkage of LAMB2 to FY (theta = 3.23, z = 3.85) and REN (theta = 0.17, z = 4.88).
Nishimura
D
D
Department of Pediatrics, University of Iowa, Iowa City 52242.
Buetow
K H
KH
Yamada
Y
Y
Murray
J C
JC
D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D007797:Laminin / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D007797:Laminin