Absence of HIV-1 infection in antibody-negative sexual partners of HIV-1 infected hemophiliacs.
In order to confirm the presence and determine the frequency of human immunodeficiency virus, type 1 (HIV-1) infection prior to antibody production, 23 healthy women with histories of repeated unprotected sexual exposure to HIV-1 infected hemophiliacs were tested for evidence of HIV-1 infection. Female subjects were tested for HIV-1 antibody (enzyme immunoassay [EIA] and Western blot), HIV-1 serum antigen, HIV-1 DNA gag sequences by the polymerase chain reaction, and HIV-1 virus isolation from peripheral mononuclear cells. Twenty-two of 23 (96%) women were negative by all HIV-1 assays. One woman was positive by all the HIV-1 assays including an EIA screening test for HIV-1 antibody. These preliminary results suggest that the frequency of HIV-1 infection in antibody-negative sexual partners of HIV-1 infected individuals is probably very low.
Jackson
J B
JB
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455.
Kwok
S Y
SY
Hopsicker
J S
JS
Sannerud
K J
KJ
Sninsky
J J
JJ
Edson
J R
JR
Balfour
H H
HH
D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000523:psychology* / Q000635:transmission; D000328:Adult; D005260:Female; D015483:HIV Antibodies / Q000032:analysis; D006679:HIV Seropositivity / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology*; D015497:HIV-1; D006467:Hemophilia A / Q000150:complications / Q000523:psychology*; D006801:Humans; D008875:Middle Aged; D012747:Sexual Partners
D015483:HIV Antibodies