Intralesional corticosteroid therapy for infantile hemangiomas.
Intralesional corticosteroid injections were performed in 31 hemangiomas in 30 infants aged 1 to 10 months at first injection. One to five injections were given, spaced 6 weeks apart. Lesions were located throughout the head and neck region, except one that was on the buttock. A mixture of betamethasone acetate and triamcinolone acetonide was used. Four lesions (13 percent) virtually disappeared, ten (32 percent) showed greater than 50 percent reduction in volume, ten (32 percent) showed definite but less than 50 percent reduction in volume, and seven (23 percent) showed little or no decrease in size. None showed further growth. All injections were performed without anesthesia, and there were not significant complications. We conclude that intralesional corticosteroid injections are safe and effective in properly selected infants with hemangiomas.
Sloan
G M
GM
Division of Plastic Surgery, Childrens Hospital of Los Angeles.
Reinisch
J F
JF
Nichter
L S
LS
Saber
W L
WL
Lew
K
K
Morwood
D T
DT
D001623:Betamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D005153:Facial Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006391:Hemangioma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007223:Infant; D007267:Injections; D008297:Male; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use*
D001623:Betamethasone; D014222:Triamcinolone Acetonide