[Flow cytophotometric measurements before and during radiotherapy of head and neck tumors].
The DNA index and proliferation activities were determined by flow cytophotometry in 59 tumors of the head and neck area. 35 tumors (59%) were aneuploid, 24 (41%) were diploid. Aneuploid tumors showed a tendency to increased formation of lymph node metastases, an increased risk of relapse as well as a shorter relapse-free interval. No correlation was found between the primary tumor stage and the incidence of aneuploid tumors. Whereas aneuploid tumors developed frequently regional recurrences, only local recurrences were observed in diploid tumors. A number of biopsies was additionally performed during radiotherapy in twelve tumors. After 10 or 20 Gy, aneuploid tumors showed a considerably increased number of S and S2 + M phase cells. In diploid tumors, substantial modifications of the cell cycle phases were not found, because it is not possible in these cases to distinguish between normal cells and tumor cells.
Fietkau
R
R
Strahlentherapeutische Klinik, Universität Erlangen.
Langer
E
E
Iro
H
H
Spitzer
W
W
Pfau
R
R
Bilek
P
P
Thiel
H J
HJ
Herbst
M
M
Sauer
R
R
D000782:Aneuploidy; D001706:Biopsy; D002453:Cell Cycle; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006258:Head and Neck Neoplasms / Q000032:analysis / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D012074:Remission Induction
D004273:DNA, Neoplasm
Impulszytophotometrische Messungen vor und während der Strahlentherapie bei Kopf-Hals-Tumoren.