title: Synthesis and antibacterial activity of novel 3-substituted carbacephems.
abstract: A series of novel 3-heterocyclothio substituted carbacephems having phenylglycyl side chain have been prepared starting from 3-H carbacephem. The compounds exhibit better chemical stability than the corresponding cephalosporin and strong activity against Gram-negative and Gram-positive organisms including Enterococcus faecalis.
authors.affiliation: Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mochida
authors.forename: T
authors.initials: T
authors.lastname: Ogasa
authors.forename: J
authors.initials: J
authors.lastname: Shimada
authors.forename: T
authors.initials: T
authors.lastname: Hirata
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: R
authors.initials: R
authors.lastname: Okachi
mesh_terms: D002511:Cephalosporins / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D004355:Drug Stability; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D002511:Cephalosporins; C026739:carbacephems