title: Dextromethorphan protects retina against ischemic injury in vivo.
abstract: Retinal ischemia was induced in rabbits by increasing intraocular pressure above systolic blood pressure for 60 or 75 minutes, and retinal function was monitored by electroretinography. Pretreatment with intravenous dextromethorphan, a nonprescription antitussive and selective antagonist of N-methyl-D-aspartate receptors, enhanced greatly the post-ischemic recovery of b-wave amplitude. Dextromethorphan may prove to be useful clinically in the management of retinal ischemic disease.
authors.affiliation: Department of Ophthalmology, Stanford University School of Medicine, CA 94305.
authors.forename: Y H
authors.initials: YH
authors.lastname: Yoon
authors.forename: M F
authors.initials: MF
authors.lastname: Marmor
mesh_terms: D000818:Animals; D003915:Dextromethorphan / Q000008:administration & dosage*; D004596:Electroretinography; D007262:Infusions, Intravenous; D007511:Ischemia / Q000473:pathology / Q000517:prevention & control*; D007981:Levorphanol / Q000031:analogs & derivatives*; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D012164:Retinal Diseases / Q000517:prevention & control; D012171:Retinal Vessels; D013997:Time Factors
chemical_list: D007981:Levorphanol; D003915:Dextromethorphan