Dementia, parkinsonism, and motor neuron disease: neurochemical and neuropathological correlates.
The neurochemical markers for the major neurotransmitter systems were measured in the brain of a patient who died with a dementia-parkinsonism-motor neuron disease (DPMN) syndrome complex. Moderate neuronal loss in the substantia nigra, spongiform changes in the frontal cortex, and moderate anterior horn cell loss throughout the spinal cord were observed. A severe nigrostriatal dopamine deficiency provides the basis for the observed parkinsonian features. The dementia is unexplained.
Gilbert
J J
JJ
Department of Pathology, Victoria Hospital, London, Ontario, Canada.
Kish
S J
SJ
Chang
L J
LJ
Morito
C
C
Shannak
K
K
Hornykiewicz
O
O
D002421:Caudate Nucleus / Q000032:analysis / Q000473:pathology; D002531:Cerebellum / Q000032:analysis / Q000473:pathology; D003704:Dementia / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D005625:Frontal Lobe / Q000032:analysis / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D018377:Neurotransmitter Agents / Q000032:analysis*; D010300:Parkinson Disease / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D013116:Spinal Cord / Q000032:analysis / Q000473:pathology; D013577:Syndrome
D018377:Neurotransmitter Agents