title: [Interaction of the plasma membranes of the cells of tumors metastasizing to the lungs with the target organ].
abstract: Cells of lines of mice transplantable tumours metastasizing into the lung have been used: lung adenocarcinoma (AL), Lewis lung carcinoma (LL), melanoma B-16 (B-16), mammary tumour MMT-1 (MMT-1), malignant subline of L-cells (LS). Hybrid vesicles were obtained for each tumour. They contain fragments of cell plasmatic membranes (PM). It has been shown that AL-, LL-, LS- and B-16-liposomes were accumulated in lung, the trapping of AL- and LL-liposomes being higher than that of the other hybrid vesicles. Despite the similar dynamics and frequency of metastatic spreading into the lung for all tumours studied, no trapping of MMT-1-vesicles in the target-organ was observed. The role of specific interaction of tumour cells PM with the endothelium of the lung capillaries in the process of organotropic metastatic spreading is discussed.
authors.forename: A G
authors.initials: AG
authors.lastname: Zolotareva
authors.forename: V P
authors.initials: VP
authors.lastname: Nikolin
authors.forename: V M
authors.initials: VM
authors.lastname: Iunker
authors.forename: E V
authors.initials: EV
authors.lastname: Gruntenko
authors.forename: V G
authors.initials: VG
authors.lastname: Budker
authors.forename: V M
authors.initials: VM
authors.lastname: Subbotin
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary; D000818:Animals; D002450:Cell Communication; D002462:Cell Membrane / Q000473:pathology; D005260:Female; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D008546:Melanoma, Experimental / Q000473:pathology / Q000556:secondary; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology*
vernacular_title: Vzaimodeĭstvie plazmaticheskikh membran kletok opukholeĭ, metastaziruiushchikh v legkie, s organom-mishen'iu.