The long-lasting state of specific nonresponsiveness induced by intravenous immunization with alloantigens is due to the generation of recirculating suppressor T cells.
We investigated whether the long-lasting state of nonresponsiveness that is induced by intravenous immunization with alloantigens is mediated by suppressor T cells, or is caused by inactivation or deletion of the relevant alloreactive T cell clones. The data from parabiosis and thoracic duct drainage experiments suggest that the state of nonresponsiveness depends on recirculating non-proliferating Ts memory cells.
Bianchi
A T
AT
Hussaarts-Odijk
L M
LM
Bril
H
H
de Ruiter
H
H
Benner
R
R
D000818:Animals; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007114:Immunization; D007156:Immunologic Memory; D007165:Immunosuppression Therapy; D007519:Isoantigens / Q000276:immunology; D017710:Lymphocyte Transfusion; D051379:Mice; D008815:Mice, Inbred Strains; D010227:Parabiosis; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013997:Time Factors; D014747:Vinblastine / Q000494:pharmacology
D007519:Isoantigens; D014747:Vinblastine