title: [Aerobic and anaerobic capacity of chronic hemodialysis patients under continuous therapy with recombinant human erythropoietin].
abstract: In earlier studies we have shown that partial correction of anemia by recombinant human erythropoietin (r-HuEPO) already after 12 weeks results in a significant increase of exercise capacity in patients on chronic hemodialysis. As causative effect increased oxygen availability with improved oxygen delivery to the tissues was assumed. To elucidate the long-term effects of a partial correction of anemia with r-HuEPO on exercise capacity, oxygen uptake at maximum exercise and at the anaerobic threshold was measured by repetitive spiroergometry. Measurements were done before, 3 months and 6 months after initiation of r-HuEPO therapy. The results are summarized below: (table; see text) Our results show that a long-term improvement of peripheral oxygen availability leads to a further increase of anaerobic threshold in patients on chronic hemodialysis even without a further increase of hemoglobin levels and without exercise training. It appears that elimination of the chronic hypoxic condition results in a restoration of previously diminished mitochondrial enzymes in muscle, particularly for aerobic glycolysis. Besides acute improvement of aerobic and anaerobic exercise capacity, the long-term administration of r-HuEPO with its increased anaerobic threshold enhances the patients' everyday life working capacity.
authors.affiliation: Medizinische Universitätsklinik, Wien.
authors.forename: G
authors.initials: G
authors.lastname: Mayer
authors.forename: J
authors.initials: J
authors.lastname: Thum
authors.forename: E M
authors.initials: EM
authors.lastname: Cada
authors.forename: H K
authors.initials: HK
authors.lastname: Stummvoll
authors.forename: H
authors.initials: H
authors.lastname: Graf
mesh_terms: D004921:Erythropoietin / Q000627:therapeutic use*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D010100:Oxygen / Q000097:blood; D005082:Physical Exertion; D006435:Renal Dialysis; D013997:Time Factors
chemical_list: D006454:Hemoglobins; D004921:Erythropoietin; D010100:Oxygen
vernacular_title: Verhalten der aeroben und anaeroben Leistungsfähigkeit chronischer Hämodialysepatienten unter einer Dauertherapie mit rekombinantem humanem Erythropoietin.