Human platelets release alpha-6-L-fucosyltransferase upon activation.
Previously we have shown that human platelets release alpha-6-L-fucosyltransferase (EC 2.4.1.68) during coagulation of blood [(1987) Glycoconjugate J. 4, 43-49]. Here we report that agonists which induce platelet aggregation bring about release of the enzyme. In quantitative terms the release of alpha-6-L-fucosyltransferase by washed, aggregated platelets was very similar to that occurring during blood coagulation.
Antoniewicz
J
J
Department of Biochemistry, Institute of Hematology, Warsaw, Poland.
Bykowska
K
K
Zdebska
E
E
Kościelak
J
J
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000201:enzymology / Q000502:physiology*; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005647:Fucosyltransferases / Q000097:blood* / Q000378:metabolism; D006602:Hexosyltransferases / Q000097:blood*; D006801:Humans; D010974:Platelet Aggregation; D012310:Ristocetin / Q000494:pharmacology; D013917:Thrombin / Q000502:physiology
D012310:Ristocetin; D000244:Adenosine Diphosphate; D003094:Collagen; D005647:Fucosyltransferases; D006602:Hexosyltransferases; C020559:Glycoprotein 6-alpha-L-fucosyltransferase; D013917:Thrombin; D004837:Epinephrine