Recurrent diabetes insipidus associated with pregnancy: pathophysiology and therapy.
Diabetes insipidus during pregnancy is an uncommon medical problem. We present a woman who developed transient central diabetes insipidus during two successive pregnancies. A water deprivation study with plasma arginine vasopressin concentrations confirmed the diagnosis and established the efficacy of 1-desamino-8-d-arginine-vasopressin (dDAVP). The patient was then successfully and safely treated through the second pregnancy with dDAVP.
Hughes
J M
JM
Department of Internal Medicine, University of Virginia Medical Center, Charlottesville.
Barron
W M
WM
Vance
M L
ML
D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D003919:Diabetes Insipidus / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006801:Humans; D009994:Osmolar Concentration; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000503:physiopathology; D012008:Recurrence; D014868:Water Deprivation; D014882:Water-Electrolyte Balance
D001127:Arginine Vasopressin; D003894:Deamino Arginine Vasopressin