[Course of antibody titer following preventive hepatitis B vaccination and a recommendation for renewal following the use of H-B-Vax vaccines].
97% of the vaccinees developed anti-HBs independently of the applied vaccine (experimental vaccine or H-B-Vax). With the experimental vaccine the mean antibody titre was 1095 IMU/ml four weeks after third inoculation. Follow up revealed that during a period of 18 month individual antibody titres declined continuously to approximately one tenth. Therefore the duration of protection depends on the titre of anti-HBs which was measured after the third immunization. A control of the antibody titres should be performed after about 3-5 years, when the antibody titres are greater than 1000 IMU/ml 4 weeks after vaccination. But a control should be made already after about 1 1/2-3 years if the antibody titres are 200-1000 IMU/ml. Antibody titres between 100 and 200 IMU/ml should be estimated about 6-18 months later and titres between 10 and 100 IMU/ml already about 3-6 months later. We recommend an immediate revaccination for persons with anti-HBs titres below 10 IMU/ml. Serological findings in hospital staff of the University in Hamburg revealed the presence of protective antibodies in 11,6% which is due to a previous hepatitis B infection. In this cases vaccination was unnecessary.
Kätzner
K
K
Kalitzky
M
M
Steinhagen-Thiessen
E
E
Gatermann
S
S
Laufs
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D006508:Hepatitis Antibodies / Q000032:analysis*; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006511:Hepatitis B Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D008875:Middle Aged; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage* / Q000276:immunology
D006508:Hepatitis Antibodies; D006511:Hepatitis B Antigens; D017325:Hepatitis B Vaccines; D014761:Viral Hepatitis Vaccines
Antikörpertiterverlauf nach Hepatitis-B-Schutzimpfung und Empfehlung zur Auffrischung nach Einsatz der H-B-Vax-Vakzine.