Regulation of receptors on parietal cells on acid secretion.
Four types of receptors have so far been identified on the parietal cell: receptors for gastrin, acetylcholine, and histamine, whose activation leads to stimulation of acid secretion, and receptors for prostaglandins of the E series, whose activation leads to inhibition of acid secretion. Postreceptor events following drug-receptor interaction include mobilization of calcium ions and cAMP formation. Moreover, a number of putative receptors (for somatostatin, CCK, adenosine, secretin, etc.) have been hypothesized, even though definite evidence is still lacking. Finally, other substances may influence gastric acid secretion in a positive or negative way, but no evidence for an involvement of specific receptors on the parietal cells is available so far.
Bertaccini
G
G
Institute of Pharmacology, University of Parma, Ospedale Maggiore, Italy.
Coruzzi
G
G
D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D010295:Parietal Cells, Gastric / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism; D011949:Receptors, Cholecystokinin / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000502:physiology*; D011970:Receptors, Histamine H2 / Q000502:physiology*; D011982:Receptors, Prostaglandin / Q000502:physiology*; D018078:Receptors, Prostaglandin E; D015290:Second Messenger Systems
D011458:Prostaglandins E; D011949:Receptors, Cholecystokinin; D011950:Receptors, Cholinergic; D011970:Receptors, Histamine H2; D011982:Receptors, Prostaglandin; D018078:Receptors, Prostaglandin E