Changes in pituitary-adrenal function under extreme cold in DHA-treated persistent estrous rats.
The plasma corticosterone levels and incorporation of 14C-l-acetate into corticosterone and cortisol were measured in dehydroepiandrosterone (DHA)-treated persistent estrous rats and control estrous cyclic rats exposed to cold (-5 degrees C) for 12 hrs. Cold exposure significantly facilitated incorporation of 14C-l-acetate into corticosterone and cortisol in both DHA-treated and control rats. However, the rates of increase of plasma corticosterone level and 14C-incorporation into corticosterone are 61% and 77% in controls, and 19% and 44% in DHA-treated rats, respectively. The activity of stress-induced pituitary-adrenal function showed masculine patterns in DHA-treated rats. The diurnal patterns of plasma corticosterone in DHA-treated rats are similar in controls. Plasma corticosterone levels in DHA-treated rats are evidently greater than those in controls. It is suggested that neonatal administration of DHA caused the changes not only in pituitary-gonadal system but also in pituitary-adrenal system.
Mohri
M
M
Seto
K
K
Nagase
M
M
D000818:Animals; D000831:Animals, Newborn; D003080:Cold Temperature; D003345:Corticosterone / Q000097:blood; D003348:Cortisone / Q000097:blood; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology
D003687:Dehydroepiandrosterone; D003348:Cortisone; D003345:Corticosterone