title: A comparison of ibuprofen and dihydrocodeine in relieving pain following wisdom teeth removal.
abstract: Although dihydrocodeine (DF118) is widely prescribed by general dental practitioners, there is little evidence that it is successful in controlling post-operative dental pain. Ibuprofen is known to be effective in this situation. A single dose, double-blind study was carried out in 148 patients to compare 400 mg ibuprofen with 30 mg dihydrocodeine and placebo for treating moderate to severe pain following the removal of unilateral, impacted mandibular third molar teeth under local anaesthesia. An additional dose of either ibuprofen or dihydrocodeine was available after 2 hours. The post-operative ibuprofen reduced pain and produced more pain relief than dihydrocodeine or placebo. Furthermore, fewer patients receiving ibuprofen took additional analgesic at 2 hours. Patients who received ibuprofen as supplementary medication also experienced less pain and had greater pain relief than those receiving dihydrocodeine as supplementary medication, even when their post-operative treatment had been placebo. More patients reported the medication as having been effective if they took ibuprofen either post-operatively or as supplementary analgesia. Ibuprofen is an appropriate analgesic for treating post-operative dental pain.
authors.forename: J W
authors.initials: JW
authors.lastname: Frame
authors.forename: C R
authors.initials: CR
authors.lastname: Evans
authors.forename: G R
authors.initials: GR
authors.lastname: Flaum
authors.forename: R
authors.initials: R
authors.lastname: Langford
authors.forename: P G
authors.initials: PG
authors.lastname: Rout
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003061:Codeine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008964:Molar, Third / Q000601:surgery*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D010919:Placebos; D014081:Tooth Extraction / Q000009:adverse effects*; D014095:Tooth, Impacted / Q000601:surgery
chemical_list: D010919:Placebos; C014481:dihydrocodeine; D003061:Codeine; D007052:Ibuprofen