Further study of effects of synthetic peptides on identifiable giant neurones of an African giant snail (Achatina fulica Férussac).
1. Effects of the following peptides at 10(-4) M on identifiable giant neurones of Achatina fulica Férussac were examined: physalaemin, eledoisin, bradykinin, neurokinin A, neurokinin B, neuromedin B, gastrin releasing peptide decapeptide (neuromedin C), gastrin releasing peptide (14-27), cholecystokinin tetrapeptide, cholecystokinin octapeptide, thyrotropin releasing hormone, Arg-vasotocin, gamma-melanocyte stimulating hormone. 2. The six neurones tested were as follows: PON (periodically oscillating neurone), TAN (tonically autoactive neurone), RAPN (right anterior pallial neurone), d-RPLN (dorsal-right parietal large neurone), VIN (visceral intermittently firing neurone) and d-VLN (dorsal-visceral large neurone). 3. Of the peptides examined, only Arg-vasotocin at 10(-4) M produced the excitatory effects on PON, VIN and d-VLN. Physalaemin showed slight inhibitory effects on TAN; this substance was sometimes almost ineffective on the neurone. 4. The other peptides examined were completely ineffective on all of the neurones tested.
Kim
K H
KH
Department of Physiology, Gifu University School of Medicine, Japan.
Takeuchi
H
H
Munekata
E
E
Yanaihara
N
N
Ariyoshi
Y
Y
D000818:Animals; D009474:Neurons / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology*; D012908:Snails
D010455:Peptides