Effects of various serum proteins on quantification of fructosamine.
We determined fructosamine concentrations with the CentrifiChem 600 centrifugal analyzer and the Hitachi 737 discrete analyzer. Reference intervals agreed with the most recently published results, and values in fasting patients were significantly correlated with glycated hemoglobin, plasma glucose, albumin, beta- and gamma-globulins, IgG, IgA, IgM, and total protein. Partial correlation analysis showed that only fructosamine and IgA were dependently related. In a group of nondiabetic patients with pathological values for IgA concentrations, 79.4% had pathological values for fructosamine. These results throw doubt on the clinical value of fructosamine determinations if serum IgA is not taken into account.
Rodriguez-Segade
S
S
Department of Biochemistry, Hospital General de Galicia, Faculty of Medicine, University of Santiago de Compostela, Spain.
Lojo
S
S
Camiña
M F
MF
Paz
J M
JM
Del Río
R
R
D000328:Adult; D000368:Aged; D001322:Autoanalysis; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins; D005215:Fasting; D005260:Female; D019270:Fructosamine; D006442:Glycated Hemoglobin / Q000378:metabolism; D006595:Hexosamines / Q000097:blood*; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007136:Immunoglobulins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011786:Quality Control; D012016:Reference Values; D012709:Serum Albumin / Q000378:metabolism; D012712:Serum Globulins / Q000378:metabolism
D001786:Blood Glucose; D001798:Blood Proteins; D019270:Fructosamine; D006442:Glycated Hemoglobin; D006595:Hexosamines; D007070:Immunoglobulin A; D007136:Immunoglobulins; D012709:Serum Albumin; D012712:Serum Globulins