[Effect of estradiol dipropionate on the development of uterine sarcoma induced by 1,2-dimethylhydrazine in mice].
The study was concerned with the influence of single dose of estradiol dipropionate on its promoting effect on 1,2-dimethylhydrazine-induced tumors in female CBA/CaLac mice. Estradiol dipropionate given within 19 weeks did not affect carcinogenesis whereas 39-week treatment stimulated uterine sarcoma development irrespective of single dose and schedule of administration.
Morozova
O V
OV
Trukhanova
L S
LS
Parfenov
Iu D
IuD
Klepikov
N N
NN
Turusov
V S
VS
D019813:1,2-Dimethylhydrazine; D000483:Alleles; D000818:Animals; D002273:Carcinogens; D003043:Cocarcinogenesis; D004127:Dimethylhydrazines / Q000633:toxicity*; D004958:Estradiol / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D005838:Genotype; D008763:Methylhydrazines / Q000633:toxicity*; D051379:Mice; D008808:Mice, Inbred CBA / Q000235:genetics; D012513:Sarcoma, Experimental / Q000139:chemically induced* / Q000453:epidemiology; D013997:Time Factors; D014594:Uterine Neoplasms / Q000139:chemically induced* / Q000453:epidemiology
D002273:Carcinogens; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D004958:Estradiol; D019813:1,2-Dimethylhydrazine; C023482:estradiol dipropionate
Vliianie éstradiola dipropionata na razvitie sarkom matki, vyzyvaemykh 1,2-dimetilgidrazinom u mysheĭ.