The use of aztreonam in the treatment of uncomplicated gonorrhoea.
A total of 57 men and 26 women with uncomplicated gonorrhoea was treated with 1 g aztreonam intramuscularly. The cure rate was 96% and included successful treatment of 4 infections due to beta-lactamase producing organisms and 8 patients with pharyngeal involvement. The minimum inhibitory concentrations of aztreonam in vitro were lower than those of penicillin and similar to cefuroxime, and side-effects were minimal. It is concluded that aztreonam is effective against Neisseria gonorrhoeae in vivo and in vitro.
Spencer
R C
RC
Talbot
M D
MD
D001398:Aztreonam / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002444:Cefuroxime / Q000494:pharmacology; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D010400:Penicillin G / Q000494:pharmacology; D000198:Spectinomycin / Q000494:pharmacology
D000198:Spectinomycin; D001398:Aztreonam; D002444:Cefuroxime; D010400:Penicillin G