Effects of vitamin A and its analogs on nonenzymatic lipid peroxidation in rat brain mitochondria.
Vitamin A (retinol) and some of its analogs exhibited varying degrees of inhibition on induced iron and ascorbic acid lipid peroxidation of rat brain mitochondria. Malonyldialdehyde production was used as an index of the extent of in vitro lipid peroxidation. The fat-soluble vitamins retinol, retinol acetate, retinoic acid, retinol palmitate, and retinal at concentrations between 0.1 and 10.0 mmol/L inhibited brain lipid peroxidation. Retinol and retinol acetate were the most effective inhibitors. It is concluded from this study that retinol and its analogs can be considered as potential antioxidant factors, more potent than some of the well-known antioxidants such as alpha-tocopherol and butylated hydroxytoluene.
Das
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Department of Biochemistry, Faculty of Medicine, National University of Singapore.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D004224:Diterpenes; D005296:Ferrous Compounds / Q000494:pharmacology; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012172:Retinaldehyde / Q000494:pharmacology; D000084562:Retinyl Esters; D014212:Tretinoin / Q000494:pharmacology; D014801:Vitamin A / Q000031:analogs & derivatives / Q000494:pharmacology*
D004224:Diterpenes; D005296:Ferrous Compounds; D005609:Free Radicals; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; C020748:ferrous sulfate; C009166:retinol acetate; D008315:Malondialdehyde; D014212:Tretinoin; D001205:Ascorbic Acid; D012172:Retinaldehyde