Beyond hybridomas. Cell identification by in situ nucleic acid hybridization.
Nucleic acid hybridization is a powerful technique that has been developed almost entirely by molecular biologists. It has the potential to identify specific types of cells with far greater sensitivity and specificity than such current methods as polyclonal or monoclonal antibodies or lectins. As the RNAs or DNAs (probes) needed for this technique become available, it is likely to replace other methods of identifying many kinds of cells in tissue sections.
Lambert
W C
WC
Department of Pathology, UMDNJ-New Jersey Medical School, Newark 07103.
D000911:Antibodies, Monoclonal / Q000096:biosynthesis; D015342:DNA Probes; D005819:Genetic Markers; D006825:Hybridomas; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length; D015347:RNA Probes
D000911:Antibodies, Monoclonal; D015342:DNA Probes; D005819:Genetic Markers; D015347:RNA Probes