title: Influence of plasma proteins on the onset of hypnotic action of intravenous midazolam.
abstract: The action of midazolam is influenced by serum protein binding as seen in the relationship between the time of onset of action of a fixed dose of the drug and the plasma albumin. Pretreatment with intravenous aspirin produces a decrease in the in vitro binding of midazolam. In vivo this is manifest as an increase in the rapidity of action of the benzodiazepines. Probenecid pretreatment will also cause a decrease in the onset time of midazolam. However, this is not due to altered plasma protein binding of the sedative.
authors.forename: N J
authors.initials: NJ
authors.lastname: Halliday
authors.forename: J W
authors.initials: JW
authors.lastname: Dundee
authors.forename: P S
authors.initials: PS
authors.lastname: Collier
authors.forename: P G
authors.initials: PG
authors.lastname: Loughran
authors.forename: K W
authors.initials: KW
authors.lastname: Harper
mesh_terms: D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000494:pharmacology; D001569:Benzodiazepines / Q000097:blood / Q000494:pharmacology*; D001798:Blood Proteins / Q000378:metabolism*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D066298:In Vitro Techniques; D008874:Midazolam; D008875:Middle Aged; D011339:Probenecid / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors
chemical_list: D001798:Blood Proteins; D006993:Hypnotics and Sedatives; D012709:Serum Albumin; D001569:Benzodiazepines; D011339:Probenecid; D001241:Aspirin; D008874:Midazolam