Increased blood flow enhances axon regeneration after spinal transection.
It is not known whether increasing the amount of blood flow to axotomized fibers in mammalian CNS can result in more robust sprouting. To find out, an intact pedicled omentum was surgically transposed to cover a collagen matrix gel used to bridge the transected cat spinal cord stumps. Control animals were similarly treated but did not receive the pedicled omentum. Twelve weeks after cord transection, animals receiving the pedicled omentum showed a 66% spinal cord blood flow increase over animals that did not. Moreover, treatment with the pedicled omentum increased the density of regenerating adrenergic axons 10-fold over the control group. These findings indicate that boosting flow with an omental graft to the collagen bridge site results in robust axonal outgrowth of spinal transected nerve fibers.
de la Torre
J C
JC
University of Ottawa Health Sciences, Ont., Canada.
Goldsmith
H S
HS
D000818:Animals; D001369:Axons / Q000502:physiology*; D002415:Cats; D003094:Collagen; D003714:Denervation; D004343:Drug Implants; D005260:Female; D007150:Immunohistochemistry; D009416:Nerve Regeneration; D009852:Omentum / Q000637:transplantation; D012039:Regional Blood Flow; D013116:Spinal Cord / Q000098:blood supply / Q000276:immunology / Q000502:physiology*; D014446:Tyrosine 3-Monooxygenase / Q000276:immunology
D004343:Drug Implants; D003094:Collagen; D014446:Tyrosine 3-Monooxygenase