Prevention of cancer at the urothelial enteric anastomotic site.
An animal model of ureterosigmoidostomy was employed to elucidate the etiology of urinary intestinal anastomotic cancer. One hundred ninety-four rats were divided into five groups: vesicosigmoidostomy rats fed water without drug (controls); those fed ammonium chloride, or sodium bicarbonate, or ascorbic acid; and, finally, vesicosigmoid interposition rats. A significantly decreased incidence of cancer was evident only in the bowel interposition group (p less than 0.001). Ascorbic acid and altered urinary pH were not prophylactic. Possible mechanisms are discussed.
Shands
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Department of Urology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
McDougal
W S
WS
Wright
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EP
D000714:Anastomosis, Surgical; D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000209:etiology / Q000517:prevention & control*; D012809:Colon, Sigmoid / Q000601:surgery*; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D012811:Sigmoid Neoplasms / Q000209:etiology / Q000517:prevention & control*; D014513:Ureter / Q000601:surgery*; D014547:Urinary Diversion / Q000009:adverse effects*