The influence of components on the rectal absorption of cefazolin in rats.
A study has been made to identify the component(s) responsible for the absorption-promoting effect of MGK medium chain glyceride preparation commercially available as a mixture of glyceryl-1-monooctanoate, glyceryl-1,3-dioctanoate, glyceryl-1,2-dioctanoate, glyceryl trioctanoate, octanoic acid and glycerol. The action of the individual constituents has been evaluated on the rectal absorption of cefazolin in conscious rats. The results indicate that the action of MGK can be completely explained by the effect of glyceryl-1-monooctanoate, which both enhanced the extent and rate of cefazolin uptake.
Van Hoogdalem
E J
EJ
Division of Pharmacology, Sylvius Laboratories, State University of Leiden, The Netherlands.
Geerts
J A
JA
De Boer
A G
AG
Breimer
D D
DD
D000285:Administration, Rectal; D000818:Animals; D002437:Cefazolin / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012007:Rectum / Q000378:metabolism
D002437:Cefazolin