Kinetic and dynamic interactions of oral viqualine and ethanol in man.
We have studied the interaction of viqualine, a 5-hydroxytryptamine (5-HT) uptake inhibitor, with ethanol in 16 healthy men aged 20 to 34 years. The subjects were randomly assigned to receive ethanol dosed to maintain blood alcohol concentrations of 17-22 mmol.l-1 (n = 8) or orange juice (n = 8) on each of two test days one week apart and preceded, in random order, by 3 days of viqualine 75 mg bd or placebo. Ethanol had no effect on steady-state viqualine concentrations or the inhibition of 5-HT uptake. Viqualine did not affect acetaldehyde concentrations or cause an aversive alcohol-sensitizing reaction. The deleterious effects of ethanol on word recall, manual tracking, body sway, and self-ratings of intoxication, sedation, and performance were not modified by the presence of viqualine. Within each beverage group performances and self-ratings on viqualine and placebo days were not different. The first dose of viqualine was associated with transient nausea. Viqualine and ethanol do not interact kinetically or dynamically on the variables examined in this study.
Sullivan
J T
JT
Clinical Pharmacology Program, Addiction Research Foundation Clinical Institute, Toronto, Canada.
Naranjo
C A
CA
Shaw
C A
CA
Kaplan
H L
HL
Kadlec
K E
KE
Sellers
E M
EM
D000079:Acetaldehyde / Q000097:blood; D000328:Adult; D000704:Analysis of Variance; D004311:Double-Blind Method; D004347:Drug Interactions; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008297:Male; D011804:Quinolines / Q000097:blood / Q000494:pharmacology*; D011897:Random Allocation; D013647:Task Performance and Analysis
D011804:Quinolines; C038919:viqualine; D000431:Ethanol; D000079:Acetaldehyde