[Lowering of adriamycin toxicity by its combined administration with a copper Cu-2 complex].
Cu-2, a new Soviet copper-complexed cytostatic, decreased acute and hematologic toxicity after lethal doses of adriamycin (AD) were given to male CBA mice. Cu-2 (3.5 mg/kg) was first injected 10 minutes after AD was given, and a second injection followed 50 minutes after the first. Relative to controls given AD alone, the mortality of Cu-2 treated mice was decreased and their lifespan increased. Leukopenia also was less pronounced and of shorter duration. The observed effect of Cu-2 may be related to its superoxide dismutase activity, which may inactivate free radical by-products of AD metabolism known to contribute significantly to the toxicity of this anti-cancer antibiotic.
Bogush
T A
TA
Sitdikova
S M
SM
Lokshin
A
A
D000818:Animals; D003300:Copper / Q000008:administration & dosage*; D004317:Doxorubicin / Q000008:administration & dosage / Q000633:toxicity*; D004359:Drug Therapy, Combination; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013997:Time Factors
D003300:Copper; D004317:Doxorubicin
Snizhenie toksichnosti adriamitsina pri kombinirovannom primenenii s kompleksnym soedineniem medi Cu-2.