title: [Treatment of metastatic adrenal carcinoma with suramin].
abstract: A right adrenocortical carcinoma (weighing 978 g) was removed from a 45-year-old man in April 1986, the tumour bed then being irradiated with 40 Gy. Subsequently discovered multiple lung metastases were treated with cisplatin, etoposide and bleomycin, without improvement. Treatment with mitotane (Lysodren) was also without effect and had to be discontinued because of severe side effects. Treatment with suramin (Germanin) was begun in August 1987. After a loading dose of 10.7 g for six weeks the lung metastases regressed almost completely. But lung metastases were again demonstrated in January 1988 during a low-dose maintenance regimen of suramin. Increased dosage arrested further growth, but achieved no regression of the metastases. The patient died unexpectedly in April 1988 of acute circulatory failure. Suramin administration had been discontinued six weeks earlier because of bronchopneumonia and general deterioration. Thrombocytopenia, coagulation disorders and moderate proteinuria were the side effects of suramin treatment.
authors.affiliation: Medizinische Universitätsklinik II und Poliklinik, Köln.
authors.forename: B
authors.initials: B
authors.lastname: Allolio
authors.forename: C
authors.initials: C
authors.lastname: Jaursch-Hancke
authors.forename: M
authors.initials: M
authors.lastname: Reincke
authors.forename: W
authors.initials: W
authors.lastname: Arlt
authors.forename: U
authors.initials: U
authors.lastname: Metzler
authors.forename: W
authors.initials: W
authors.lastname: Winkelmann
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000097:blood / Q000188:drug therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002277:Carcinoma / Q000097:blood / Q000188:drug therapy*; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D012074:Remission Induction; D013498:Suramin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D013498:Suramin
vernacular_title: Behandlung des metastasierten Nebennierenkarzinoms mit Suramin.