title: Preparative high-performance liquid chromatography of peptides on a new reversed-phase packing material, Kromasil C18.
abstract: Preparative reversed-phase high-performance liquid chromatography has found wide use in the production of peptides for pharmaceutical formulations. Purity of the substance and overall economy of the chromatographic system are the most important criterias. In this sense optimized, silica particles and production process with capability to separately control parameters important to chromatography, are essential to high-performance chromatography. Kromasil C18 packing material was tested and evaluated in respect of its selectivity, flow and pressure properties, resolution, load capacity, recovery, adsorption effects, mechanical strength and chemical degradation.
authors.affiliation: Ferring Pharmaceuticals, Malmö, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Larsson
authors.forename: W
authors.initials: W
authors.lastname: Hermann
authors.forename: P
authors.initials: P
authors.lastname: Möller
authors.forename: D
authors.initials: D
authors.lastname: Sanchez
mesh_terms: D002851:Chromatography, High Pressure Liquid; D009842:Oligopeptides / Q000032:analysis / Q000302:isolation & purification*; D010121:Oxytocin / Q000032:analysis / Q000302:isolation & purification*; D013004:Somatostatin / Q000032:analysis / Q000302:isolation & purification*; D014667:Vasopressins / Q000032:analysis / Q000302:isolation & purification*
chemical_list: D009842:Oligopeptides; D014667:Vasopressins; D010121:Oxytocin; D013004:Somatostatin