A primary map of ten DNA markers and two serological markers for human chromosome 19.
We have constructed a primary map of 10 DNA and 2 protein markers for chromosome 19. Three of the markers define loci with a variable number of tandem repeats (VNTRs); 3 define genes--insulin receptor, low-density lipoprotein (LDL) receptor, and apolipoprotein CII; and 2 are classical markers for blood group antigens (Lewis and Secretor). The estimated genetic distance covered by the map is 137 cM in males and 189 cM in females. In some regions of the chromosome we found significant differences in recombination frequencies according to sex. This set of markers will be efficient for linkage studies in families segregating genetic defects and will provide anchor points for a high-resolution map of chromosome 19.
Nakamura
Y
Y
Howard Hughes Medical Institute, University of Utah Health Sciences Center, Salt Lake City 84132.
Lathrop
M
M
O'Connell
P
P
Leppert
M
M
Lalouel
J M
JM
White
R
R
D000483:Alleles; D053304:Apolipoprotein C-II; D001056:Apolipoproteins C / Q000235:genetics*; D001789:Blood Group Antigens / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D005796:Genes; D005819:Genetic Markers / Q000097:blood; D006801:Humans; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D011972:Receptor, Insulin / Q000235:genetics*; D011973:Receptors, LDL / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D012737:Sex Factors
D053304:Apolipoprotein C-II; D001056:Apolipoproteins C; D001789:Blood Group Antigens; D005819:Genetic Markers; D011973:Receptors, LDL; D004247:DNA; D011972:Receptor, Insulin