title: [Hemodynamic effects of an etomidate-flunitrazepam or midazolam- fentanyl combination for induction of anesthesia in patients with heart valve diseases].
abstract: A comparison of the haemodynamic effects of 3 anaesthetic techniques, the combinations etomidate + fentanyl (I), flunitrazepam + fentanyl (II) or midazolam + fentanyl (III), respectively was carried out in 45 patients undergoing various types of cardiac valve replacement surgery. Haemodynamics were assessed by continuously measuring the heart rate as well as the blood pressure in the systemic and pulmonary circulations whereas the cardiac output was measured intermittently. In the first 30 minutes after induction of anaesthesia, a mean arterial blood pressure drop of 10% (I), 20% (II) or 15% (III) respectively, was observed; at the same time, the rate did not change significantly. Cardiac index, however, fell significantly in all 3 groups by 33% (I) 30% (II) or 28% (III), respectively. Pulmonary pressure, wedge pressure and systemic vascular resistance rose only in groups I and III and decreased in group II (flunitrazepam + fentanyl). On the other hand, pulmonary vascular resistance as well as left ventricular work index were significantly decreased in all 3 groups. We conclude that all 3 anaesthetic techniques investigated here may be effectively applied for safe induction of anaesthesia in patients with valvular lesions of the heart. On account of the effect of the combination flunitrazepam + fentanyl on decreasing pulmonary artery pressure and wedge pressure, this technique seems to be preferable in patients with pulmonary hypertension.
authors.forename: H K
authors.initials: HK
authors.lastname: Murday
authors.forename: G
authors.initials: G
authors.lastname: Hack
authors.forename: E
authors.initials: E
authors.lastname: Hermanns
authors.forename: A
authors.initials: A
authors.lastname: Rudolph
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology*; D001569:Benzodiazepines / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004338:Drug Combinations; D005045:Etomidate / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000494:pharmacology*; D005445:Flunitrazepam / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006349:Heart Valve Diseases / Q000150:complications*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications; D008297:Male; D008874:Midazolam; D008875:Middle Aged; D011229:Preanesthetic Medication
chemical_list: D000777:Anesthetics; D004338:Drug Combinations; D001569:Benzodiazepines; D005445:Flunitrazepam; D008874:Midazolam; D005283:Fentanyl; D005045:Etomidate
vernacular_title: Hämodynamische Effekte einer Kombination von Etomidat, Flunitrazepam oder Midazolam mit Fentanyl zur Anästhesie-Einleitung bei Patienten mit Herzklappenvitien.