Inhibition of metastases of a human melanoma xenograft by monoclonal antibody to the GD2/GD3 gangliosides.
A human melanoma variant cell line was obtained from a lung metastasis that arose spontaneously after we inoculated melanoma cells sc into a nude mouse. In this model, IgG2a monoclonal antibody (MAb) ME 36.1 defining the GD2/GD3 gangliosides inhibited melanoma growth at the primary site and metastatic spread of the cells, whereas an IgG1 variant of MAb ME 36.1 inhibited lung metastasis formation only. Possible mechanisms of antitumor effects of MAb ME 36.1 are discussed.
Iliopoulos
D
D
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
Ernst
C
C
Steplewski
Z
Z
Jambrosic
J A
JA
Rodeck
U
U
Herlyn
M
M
Clark
W H
WH
Koprowski
H
H
Herlyn
D
D
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002448:Cell Adhesion; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008207:Lymphatic Metastasis / Q000473:pathology; D008546:Melanoma, Experimental / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous
D000911:Antibodies, Monoclonal; D005732:Gangliosides; C026226:ganglioside, GD3; C019403:ganglioside, GD2