title: [Homologous cerebral atrophy and ischemic insults in progeria adultorum].
abstract: Neuropathological findings obtained from a female patient, 49 years of age, with progeria adultorum (Werner's syndrome) are described in this paper. Vascular sclerosis with multiple ischaemic infarctions, cerebral atrophy, and vascular myelopathy were the most strongly pronounced CNS findings. Also recorded were severe lipofuscin depositions from the cortex, dentate nucleus, and olivae as well as amylaceous bodies in the insula of Reil and the hippocampus. Neurofibrillary tangles or plaques were not recordable. The central nervous system proved somewhat comparable to other organs, in that mesenchymal regressive changes were the main features.
authors.affiliation: Institut für Neuropathologie, Freien Unversität Berlin, West.
authors.forename: J
authors.initials: J
authors.lastname: Haustein
authors.forename: U
authors.initials: U
authors.lastname: Pawlas
authors.forename: J
authors.initials: J
authors.lastname: Cervós-Navarro
mesh_terms: D001284:Atrophy; D001921:Brain / Q000473:pathology*; D002529:Cerebellar Nuclei / Q000032:analysis / Q000473:pathology; D002540:Cerebral Cortex / Q000032:analysis / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000032:analysis / Q000473:pathology; D006801:Humans; D008062:Lipofuscin / Q000032:analysis; D008875:Middle Aged; D009847:Olivary Nucleus / Q000032:analysis / Q000473:pathology; D014898:Werner Syndrome / Q000473:pathology*
chemical_list: D008062:Lipofuscin
vernacular_title: Homologe zerebrale Atrophie und ischämische Insulte bei Progeria adultorum.