Satiety and sleep: the effects of bombesin.
Our recently proposed ischymetric hypothesis of the control of feeding and sleep predicts that both of these phenomena must be closely related. Whether food was available or not, peripherally administered bombesin produced an enhancement of total sleep by specifically increasing the duration of slow wave sleep but not the duration of paradoxical sleep. In all experimental situations, paradoxical sleep latency was increased. The data suggest an active role for endogenous bombesin-like peptides in the regulation of satiety and sleep.
de Saint Hilaire-Kafi
Z
Z
Neurobiologie des Régulations, Collège de France, Paris.
Gibbs
J
J
Nicolaïdis
S
S
D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005508:Food Deprivation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects*
D001839:Bombesin