The immunopathology of olfactory nerve injury and hemorrhage in gerbils.
Patients with head injury may experience olfactory dysfunction. Unfortunately, little is known about changes in the olfactory neuroepithelium caused by intracranial olfactory nerve injury and hemorrhage. We performed olfactory nerve section or bulbectomy in 53 Mongolian gerbils and subjected the olfactory neuroepithelium to immunohistochemical analysis. A decrease or disappearance of the antiserum to an olfactory marker protein containing olfactory receptor neurons was evident in the sectioned group. Degeneration of the olfactory neuroepithelium contralateral to olfactory nerve injury was also noted in animals with perineural hemorrhage. These findings suggest that olfactory dysfunction may occur not only with nerve injury but also secondary to intracranial hemorrhage.
Nakashima
T
T
Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Inamitsu
M
M
D000818:Animals; D005849:Gerbillinae; D006470:Hemorrhage / Q000473:pathology*; D009830:Olfactory Bulb / Q000473:pathology; D061219:Olfactory Nerve Injuries; D011984:Sensory Receptor Cells / Q000473:pathology