Deaths and tumors among workers grinding stainless steel.
This study examined a cohort of 1,164 males who, during the period 1927-1981, had been employed for 3 months or more in an industry that produced objects from stainless steel. These workers were exposed to the dust of grinding materials, grinding agents, and stainless steel. From 1975 to 1980, measurements of the total dust in the workroom air have shown levels of about one mg/m3 (consisting of chromium at about 0.1 mg/m3 and nickel at about 0.05 mg/m3) during grinding and several mg/m3 (chromium at about 0.01 mg/m3 and nickel at about 0.005 mg/m3) during polishing. Before 1950, the concentrations were probably considerably higher. Compared to a local reference population, a decrease in mortality (63 observed deaths, standardized mortality (SMR) = 0.79, 95% confidence limits CL = 0.61, 1.01) took place during the 1951-1983 observation period among 318 subjects who had been employed for at least five years, allowing a latency period of at least 20 years. Mortality from cancer of the colon/rectum increased (observed deaths = 6, SMR = 2.47, CL = 0.97, 5.58). The mortality from nonmalignant pulmonary disease did not increase (SMR = 0.29, CL = 0.01, 1.81). During the observation period (1958-1983), there was no significant overall excess of tumors (observed cases = 33, standardized morbidity [SMR] = 1.09, CL = 0.76, 1.54). However, tumor morbidity of the colon/rectum (observed 11, SMR = 2.83, CL = 1.47, 5.19) significantly increased. There were no cases of respiratory cancer (expected 4.7, CL = 0, 0.21). Thus, the results indicate an increased risk of intestinal cancer.(ABSTRACT TRUNCATED AT 250 WORDS)
Svensson
B G
BG
Department of Occupational Medicine, University Hospital, Lund, Sweden.
Englander
V
V
Akesson
B
B
Attewell
R
R
Skerfving
S
S
Ericson
A
A
Möller
T
T
D002857:Chromium / Q000009:adverse effects*; D015331:Cohort Studies; D004938:Esophageal Neoplasms / Q000139:chemically induced* / Q000401:mortality; D005500:Follow-Up Studies; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced* / Q000401:mortality; D006801:Humans; D008223:Lymphoma / Q000139:chemically induced* / Q000401:mortality; D008297:Male; D008669:Metallurgy; D009101:Multiple Myeloma / Q000139:chemically induced* / Q000401:mortality; D009532:Nickel / Q000009:adverse effects*; D009784:Occupational Diseases / Q000139:chemically induced*; D013193:Stainless Steel / Q000009:adverse effects*; D013223:Statistics as Topic; D013548:Sweden
D002857:Chromium; D013193:Stainless Steel; D009532:Nickel