Prefrontal cortex lesions attenuate substantia nigra self-stimulation: a reward summation analysis.
A curve-shift paradigm was used to assess the effects of lesions of the prefrontal cortex on self-stimulation from electrode sites in the substantia nigra. Combined lesions of the medial and sulcal cortical regions severely attenuated substantia nigra self-stimulation. These results are discussed in the context of the frontal cortex and the substantia nigra as belonging to a reinforcement system that is largely independent of the medial forebrain bundle system.
Silverman
J A
JA
University of Pittsburgh School of Medicine, PA.
Corbett
D
D
D000818:Animals; D001931:Brain Mapping; D004558:Electric Stimulation; D005625:Frontal Lobe / Q000502:physiology*; D008297:Male; D009042:Motivation / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology; D012653:Self Stimulation / Q000502:physiology*; D013378:Substantia Nigra / Q000502:physiology*
D011954:Receptors, Dopamine