title: Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells.
abstract: The degradation of type IX collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (MMPs) purified from the culture medium of rheumatoid synovial cells. Neither MMP-1 (collagenase) nor MMP-2 (so-called 'gelatinase') could digest type IX collagen, but MMP-3 (stromelysin) readily degraded it into smaller fragments. This suggests that MMP-3 may be responsible for the pathological degradation and/or normal turnover of type IX collagen.
authors.affiliation: Department of Pathology, School of Medicine, Kanazawa University, Ishikawa, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
authors.forename: H
authors.initials: H
authors.lastname: Konomi
authors.forename: T
authors.initials: T
authors.lastname: Yada
authors.forename: K
authors.initials: K
authors.lastname: Kimata
authors.forename: H
authors.initials: H
authors.lastname: Nagase
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000201:enzymology*; D002478:Cells, Cultured; D002642:Chick Embryo; D003094:Collagen / Q000378:metabolism*; D006801:Humans; D019278:Matrix Metalloproteinase 3; D008666:Metalloendopeptidases / Q000302:isolation & purification / Q000378:metabolism*; D013379:Substrate Specificity; D013582:Synovial Fluid / Q000201:enzymology*
chemical_list: D003094:Collagen; D008666:Metalloendopeptidases; D019278:Matrix Metalloproteinase 3