Effects of indomethacin and diclofenac on some functions of polymorphonuclear neutrophils.
The effects in-vitro of two non-steroidal anti-inflammatory drugs, diclofenac and indomethacin, have been studied on human polymorphonuclear functions. Adhesivity and chemotaxis were decreased by the two drugs, but in a manner that varied with the attractant used. As shown by the nitro blue tetrazolium slide test, all cells remained active but the production of oxygen metabolites by opsonized zymosan was decreased in the presence of diclofenac.
Berradia
N
N
Centre régional de Transfusion Sanguine et d'Hématologie, Vandoeuvre les Nancy, France.
Marchand-Arvier
M
M
Humbert
J C
JC
Vigneron
C
C
D002448:Cell Adhesion / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003574:Cytochrome c Group / Q000378:metabolism; D004008:Diclofenac / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology; D009580:Nitroblue Tetrazolium; D013481:Superoxides / Q000378:metabolism
D003574:Cytochrome c Group; D013481:Superoxides; D004008:Diclofenac; D009580:Nitroblue Tetrazolium; D007213:Indomethacin