A nonparametric method for evaluating results from laboratory antinociceptive tests.
A method is presented in which Cox's proportional hazards model, a survival analysis technique, is used to assess the results of hot-plate antinociceptive testing. The method appropriately handles censored data values and variable pretest latency times without making arbitrary assumptions about the distribution of the data. It may be used to characterize and compare dose-response curves or to examine the effect of agent or other treatment variables on the response. The technique is easily implemented using the SAS statistical software package. Due to the similar way in which data is obtained, we believe the method to be applicable to several other laboratory models of pain, including the tail-flick, tail-immersion, and paw-pressure (Randall-Selitto) assays.
Taulbee
J D
JD
Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239-8707.
Kasting
G B
GB
D000700:Analgesics / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D008297:Male; D008960:Models, Psychological; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time
D000700:Analgesics; D000701:Analgesics, Opioid