title: Effect of intravenous glucagon and glucagon-(1-21)-peptide on motor activity of sphincter of Oddi in humans.
abstract: Glucagon-(1-21)-peptide, the peptide containing the amino acid sequence (1-21) of glucagon, has the same spasmolytic effect as the complete molecule, without its metabolic action. The effect of glucagon and glucagon-(1-21)-peptide on sphincter of Oddi motor activity was evaluated in 20 patients undergoing ERCP and endoscopic biliary manometry. Glucagon produced a nonsignificant decrease in basal pressure, but significantly reduced both frequency and amplitude of phasic activity of the sphincter of Oddi. Glucagon-(1-21)-peptide showed no effect on basal pressure and amplitude of phasic activity, but provoked a significant reduction of frequency of phasic contraction.
authors.affiliation: Gastroenterology Unit, Hospital La Fe, Valencia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ponce
authors.forename: V
authors.initials: V
authors.lastname: Garrigues
authors.forename: V
authors.initials: V
authors.lastname: Pertejo
authors.forename: T
authors.initials: T
authors.lastname: Sala
authors.forename: M J
authors.initials: MJ
authors.lastname: Lazaro
authors.forename: A
authors.initials: A
authors.lastname: De Val
authors.forename: J
authors.initials: J
authors.lastname: Picazo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater / Q000502:physiology*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D004311:Double-Blind Method; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000502:physiology; D010446:Peptide Fragments / Q000494:pharmacology*; D011897:Random Allocation; D009803:Sphincter of Oddi / Q000187:drug effects / Q000502:physiology*
chemical_list: D010446:Peptide Fragments; C043386:glucagon (1-21); D005934:Glucagon