[Assessment of the clinical activity of fluoxetin (Prozac) according of the "Stars of Liège" model].
Ten psychiatrists have independently rated the clinical profile of fluoxetin (Prozac) at the daily dose of 20 mg according to a "Stars of Liège" model comprising three parameters of therapeutic activity (antidepressant, psychostimulant and anxiolytic) and three parameters of side-effects (anticholinergic, sedative and hypotensive). Each parameter, graduated from 0 to 5 (no, very weak, weak, moderate, potent, very potent effect) was rated by each investigator according to his personal experience with at least 10 patients. Mean ratings given to fluoxetine show a moderate antidepressant effect, equal to amitriptyline (Rédomex, Tryptizol 75 mg/d, clomipramine (Anafranil 75 mg/d and nialamide (Niamide 100 mg/d, weak psychostimulating and anxiolytic effects, a very weak sedative effect and a lack of anticholinergic and hypotensive effects. Digestive side-effects of moderate intensity were also noted as well as a very weak anorexia. The important variability between investigators in the rating of the clinical profile of fluoxetine suggests that more experience is needed in order to define better its physiognomy.
Ansseau
M
M
Unité de Psychiatrie, Centre Hospitalier Universitaire de Liège.
Bataille
M
M
Bobon
D
D
Cerfontaine
J L
JL
Charles
G
G
Couteaux
F
F
Diricq
S
S
Fraipont
J
J
Gernay
P
P
Troisfontaines
B
B
D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D004341:Drug Evaluation; D005473:Fluoxetine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D008960:Models, Psychological; D010276:Parasympatholytics / Q000627:therapeutic use
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D000959:Antihypertensive Agents; D006993:Hypnotics and Sedatives; D010276:Parasympatholytics; D005473:Fluoxetine
Evaluation de l'activité clinique de la fluoxétine (Prozac) selon "les étoiles de Liège".