Effect of troxerutin and methionine on spin trapping of free oxy-radicals.
The cardioprotective agents troxerutin and methionine are radical scavengers and compete with the DMPO adduct formation of .OH generated by the Fenton reaction. The concentration of trapped .O2- generated by the xanthine oxidase/hypoxanthine reaction is lowered in the presence of troxerutin. The decay of DMPO-OH is decreased by troxerutin compared to the control. In the presence of methionine a carbon-centered radical is produced. The investigations support the opinion that the scavenging of oxygen derived free radicals is of importance for the cardioprotective action of these agents.
Blasig
I E
IE
Academy of Sciences of the GDR, Inst. Drug. Res, Berlin.
Loewe
H
H
Ebert
B
B
D000925:Anticoagulants; D003497:Cyclic N-Oxides; D004226:Dithioerythritol; D004578:Electron Spin Resonance Spectroscopy; D000431:Ethanol; D005609:Free Radicals; D006878:Hydroxides; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives*; D017665:Hydroxyl Radical; D008042:Linolenic Acids; D008353:Mannitol; D008715:Methionine; D012431:Rutin / Q000031:analogs & derivatives*; D013113:Spin Labels; D017962:alpha-Linolenic Acid
D000925:Anticoagulants; D003497:Cyclic N-Oxides; D005609:Free Radicals; D006878:Hydroxides; D006896:Hydroxyethylrutoside; D008042:Linolenic Acids; D013113:Spin Labels; D017962:alpha-Linolenic Acid; D017665:Hydroxyl Radical; D000431:Ethanol; D008353:Mannitol; D012431:Rutin; D004226:Dithioerythritol; C017245:5,5-dimethyl-1-pyrroline-1-oxide; C005865:troxerutin; D008715:Methionine