[Determination of the leading factors in the pathogenesis of an alcoholic lesion of the heart].
Male rats were given per os 25% ethanol solution twice a day at 9.00 and 21.00 for 5.5 consecutive days. Every single dose was 2 to 5 g/kg 2 and 12 hours after 8th gavage ethanol, acetaldehyde and acetone concentrations were measured in blood, 2-8 hours after the last (11th) gavage isolated hearts were perfused by Krebs-Henseleit solution. Applying of Spearman rank correlation method demonstrated negative correlation between mean acetaldehyde concentration and maximal systolic pressure, tension-time index of left ventricle and velocity of contraction and relaxation. Negative correlation has been shown between maximal ethanol concentration (MEC) and rate heart whereas positive correlation has been noticed between MEC and leakage of creatine phosphokinase.
Nuzhnyĭ
V P
VP
Zabirova
I G
IG
Abdrashitov
A Kh
AKh
Uspenskiĭ
A E
AE
D000079:Acetaldehyde / Q000097:blood; D000096:Acetone / Q000097:blood; D000818:Animals; D002310:Cardiomyopathy, Alcoholic / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D051381:Rats; D013997:Time Factors
D000096:Acetone; D000431:Ethanol; D000079:Acetaldehyde
Opredelenie vedushchikh faktorov v patogeneze alkogol'nogo porazheniia serdtsa.