Pulmonary resistance during halothane anesthesia is not determined only by airway caliber.
Studies of the effect of halothane on airway smooth muscle have used pulmonary resistance as an index of airway caliber. However, pulmonary resistance (RL) is the sum of airway resistance (Raw), which changes with airway caliber, and of tissue resistance (Rti), which depends on the pressure-volume hysteresis of the lung. To separate the effects of halothane on airway caliber from its possible effects on tissue pressure-volume hysteresis in the unstimulated lung and during bronchoconstriction, the authors measured both components of RL before and during vagus nerve stimulation in 12 dogs before and during halothane administration. Rti was always the major component of RL, constituting 77 +/- 14% (mean +/- SD) of RL before vagus nerve stimulation and 64 +/- 21% of RL during stimulation in the absence of halothane. Vagus nerve stimulation caused approximately equal increases in both Rti and Raw. Halothane attenuated the response of both Rti and Raw to vagus nerve stimulation in a dose-dependent fashion. At 1 MAC, the Rti response was 44 +/- 13% of its value before halothane administration and the Raw response was 32 +/- 12% of its value before halothane administration; these responses were not significantly different. The authors conclude that changes in RL during halothane administration are caused not only by changes in airway caliber, as previously assumed, but also reflect a significant effect of halothane on lung tissue pressure-volume hysteresis.
Warner
D O
DO
Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905.
Vettermann
J
J
Brusasco
V
V
Rehder
K
K
D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D001696:Biomechanical Phenomena; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D006221:Halothane / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D012121:Respiration, Artificial / Q000295:instrumentation / Q000379:methods; D014630:Vagus Nerve / Q000502:physiology
D006221:Halothane