Does platelet serotonin receptor supersensitivity accompany endogenous depression?
In a population of drug-free bipolar and unipolar depressed women, it was found that the concentration of serotonin sufficient to induce half-maximal shape change velocity in platelets is significantly (p less than 0.001) lower (0.13 +/- 0.0.04 microM) than that of closely matched controls (0.532 +/- 0.1 microM). This platelet concentration becomes higher after 1-3 months of antidepressant treatment (0.47 +/- 0.16 microM). Possible mechanisms for this up- or down-regulation of platelet serotonin receptor responsiveness are discussed.
Brusov
O S
OS
Institute of Clinical Psychiatry, All-Union Center for Mental Health of the Academy of Medical Science, Moscow, U.S.S.R.
Beliaev
B S
BS
Katasonov
A B
AB
Zlobina
G P
GP
Factor
M I
MI
Lideman
R R
RR
D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy*; D001792:Blood Platelets / Q000187:drug effects*; D002227:Carbazoles / Q000627:therapeutic use; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D008376:Maprotiline / Q000627:therapeutic use; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000097:blood*
D000928:Antidepressive Agents; D002227:Carbazoles; D011985:Receptors, Serotonin; D008376:Maprotiline; D012701:Serotonin; D007099:Imipramine; C009830:pirlindole