Cardiosuppressive effect of alpha-human atrial natriuretic polypeptide (alpha-hANP) in spontaneously hypertensive rats.
The hemodynamic effects of alpha-hANP were investigated in anesthetized WKY and SHR. Intravenous administration of alpha-hANP (30 ng/min per 100 g bw) caused a marked and rapid reduction in mean blood pressure (MBP) and cardiac index (CI) without any change in the total peripheral resistance index in both strains of rat. The reduction in MBP and CI was significantly greater in SHR than in WKY. It is suggested that SHR may have an enhanced cardiovascular response to alpha-hANP, but the detailed mechanism of such a response is not known.
Sasaki
A
A
Kida
O
O
Kangawa
K
K
Matsuo
H
H
Tanaka
K
K
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D009320:Atrial Natriuretic Factor