Functional and metabolic protection of the neonatal myocardium from ischemia. Insufficient protection by cardioplegia.
The effects of ischemia and cardiac arrest by cardioplegia on the mechanical function and energy metabolism of the ventricular myocardium of the neonatal guinea pig were investigated in the isolated perfused heart preparation and compared with these effects in the adult guinea pig. Whereas reperfusion after ischemia resulted in better recovery of mechanical function and a higher adenosine triphosphase content in the neonatal myocardium than in the adult, recovery from cardiac arrest induced by St. Thomas' Hospital cardioplegic solution was not as good in the neonatal myocardium as in the adult. Contracture developed in the neonatal myocardium on administration of the cardioplegic solution, but did not in the adult. This was considered to be the reason that the protective effect of the cardioplegic solution was inferior in the neonatal myocardium to that in the adult.
Watanabe
H
H
Department of Pharmacology, Niigata University School of Medicine, Japan.
Yokosawa
T
T
Eguchi
S
S
Imai
S
S
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure; D003326:Coronary Circulation; D003327:Coronary Disease / Q000517:prevention & control*; D006168:Guinea Pigs; D006321:Heart / Q000503:physiopathology*; D006324:Heart Arrest, Induced; D006801:Humans; D066298:In Vitro Techniques; D007773:Lactates / Q000378:metabolism; D015425:Myocardial Reperfusion; D010725:Phosphocreatine / Q000378:metabolism
D007773:Lactates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate