title: The effect of pretreatment with magnesium sulfate on the initiation of seizure foci in anesthetized cats.
abstract: The therapeutic effect of magnesium sulfate remains unknown. Its role as an anticonvulsant is controversial. The effect of pretreatment with parenteral magnesium sulfate on the ability to initiate penicillin-induced seizure foci in anesthetized cats was studied. All animals in the experimental group achieved serum magnesium levels of greater than 10 mg/dl. No significant difference in epileptic spike frequency between the experimental and control groups was demonstrated.
authors.affiliation: Department of Obstetrics and Gynecology, University of Louisville School of Medicine, Kentucky.
authors.forename: W L
authors.initials: WL
authors.lastname: Koontz
authors.forename: K H
authors.initials: KH
authors.lastname: Reid
mesh_terms: D000758:Anesthesia; D000818:Animals; D002415:Cats; D004562:Electrocardiography; D007262:Infusions, Intravenous; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000494:pharmacology*; D010406:Penicillins; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D010406:Penicillins; D008278:Magnesium Sulfate