2-Deoxy-D-glucose accumulation in adipocytes: apparent transport discrimination between 2-deoxy-D-glucose and 3-O-methyl-D-glucose.
The uphill accumulation of free 2-deoxy-D-glucose and 2-deoxy-D-glucose 6-phosphate in rat adipocytes was found not to affect the steady-state distribution of 3-O-methyl-D-glucose although both hexoses share a common transport pathway. This observation argues against a possible effect of 2-deoxy-D-glucose phosphate on the equilibrating nature of the carrier. The results are discussed in light of hypotheses advanced to explain free 2-deoxy-D-glucose accumulation in a variety of cells.
Thompson
K A
KA
Department of Physiology, University of Pennsylvania, Philadelphia 19104.
Kleinzeller
A
A
D019325:3-O-Methylglucose; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D019298:Glucose-6-Phosphate / Q000031:analogs & derivatives*; D005958:Glucosephosphates / Q000378:metabolism; D008757:Methylglucosides / Q000378:metabolism*; D008759:Methylglycosides / Q000378:metabolism*; D051381:Rats
D003837:Deoxy Sugars; D005958:Glucosephosphates; D008757:Methylglucosides; D008759:Methylglycosides; D019325:3-O-Methylglucose; C015785:2-deoxyglucose-6-phosphate; D019298:Glucose-6-Phosphate; D003847:Deoxyglucose