UV-A induced lipid peroxidation in liposomal membrane.
UV-A (365 nm) produced a dose-dependent linear increase of lipid peroxidation, as detected by the assay of malondialdehyde (MDA). MDA formation was inversely related to the UV-A dose rate. Sodium formate and ethylenediaminetetra acetic acid (EDTA) could not inhibit by any significant degree the UV-A induced MDA formation. While butylated hydroxy toluene (BHT) caused about 85% inhibition, sodium azide and L-histidine produced 45-50% inhibition of MDA formation. The involvement of singlet oxygen (1O2) in the UV-A induced lipid peroxidation is discussed.
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Biophysics Division, Saha Institute of Nuclear Physics, Calcutta, India.
Agarwal
S
S
Chatterjee
S N
SN
D005609:Free Radicals; D015227:Lipid Peroxidation / Q000528:radiation effects*; D008081:Liposomes / Q000378:metabolism*; D008315:Malondialdehyde / Q000032:analysis; D008566:Membranes / Q000378:metabolism; D014466:Ultraviolet Rays
D005609:Free Radicals; D008081:Liposomes; D008315:Malondialdehyde