Effect of 4-methylpyrazole on ethanol-induced decrease in rat plasma amino acids.
It has been shown earlier that an acute dose of ethanol causes an immediate decrease in the concentration of most plasma amino acids, and that this decrease involves both beta-adrenergic and adrenocortical mechanisms. In this work is shown that the oxidation of ethanol also plays an important role in the amino acid decreasing effect. Male rats were pretreated with 4-methylpyrazole, an inhibitor of liver alcohol dehydrogenase, in doses causing an 85% inhibition of the ethanol elimination. In this group the ethanol-induced decrease in amino acids was much less pronounced than in a control group pretreated with saline.
Hagman
M
M
Department of Clinical Chemistry, Gothenburg University, Sahlgren's Hospital, Sweden.
Jagenburg
R
R
D000596:Amino Acids / Q000097:blood*; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D000077604:Fomepizole; D008297:Male; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D011720:Pyrazoles; D000431:Ethanol; D000077604:Fomepizole