title: Diazepam mixed micelle--comparison with diazepam in propylene glycol and midazolam.
abstract: A mixed micelle formulation of diazepam was compared with midazolam and diazepam in propylene glycol for evidence of venous intolerance following IV injection. The overall incidence of venous morbidity was 17% for diazepam mixed micelle, 26% for midazolam and 90% for diazepam in propylene glycol. Diazepam mixed micelle is suggested as a preferable alternative to the standard formulation.
authors.forename: D C
authors.initials: DC
authors.lastname: Galletly
authors.forename: L F
authors.initials: LF
authors.lastname: Wilson
authors.forename: B C
authors.initials: BC
authors.lastname: Treuren
authors.forename: B P
authors.initials: BP
authors.lastname: Boon
mesh_terms: D001569:Benzodiazepines / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D003975:Diazepam / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008823:Micelles; D008874:Midazolam; D010146:Pain / Q000209:etiology; D014677:Pharmaceutical Vehicles; D011409:Propylene Glycols; D013927:Thrombosis / Q000139:chemically induced; D014680:Veins / Q000187:drug effects
chemical_list: D008823:Micelles; D014677:Pharmaceutical Vehicles; D011409:Propylene Glycols; D001569:Benzodiazepines; D003975:Diazepam; D008874:Midazolam