Effect of theophylline on the proportion and function of T-suppressor cells in asthmatic children.
T-cell subpopulations and their function were studied in asthmatic children with or without theophylline therapy. A decreased proportion and function of theophylline-sensitive T-suppressor cells was found in fresh peripheral blood of asthmatic children. Following peripheral blood mononuclear cells (PBMC) incubation in theophylline-free medium, the proportion of theophylline-sensitive T-cells in asthmatic children treated with theophylline was elevated to normal values. However, their suppressive effect on control lymphocyte proliferation was unchanged.
Lahat
N
N
Nir
E
E
Horenstien
L
L
Colin
A A
AA
D000293:Adolescent; D001249:Asthma / Q000188:drug therapy / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000145:classification / Q000187:drug effects / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology; D013806:Theophylline / Q000494:pharmacology* / Q000627:therapeutic use
D013806:Theophylline