The sorption of isosorbide dinitrate to intravenous delivery systems.
The sorption of isosorbide dinitrate from 0.9% sodium chloride and 10% glucose solutions, by intravenous delivery systems has been investigated under simulated infusion conditions. Isosorbide dinitrate was stable in both 0.9% sodium chloride and 10% glucose solutions. Intravenous fluid containers, burettes, a syringe, infusion sets and end-line filters were evaluated. Glass containers, methacrylate butadiene styrene burettes and polybutadiene giving sets did not sorb isosorbide dinitrate. Neither did polypropylene syringes when a 10% glucose solution was used. The sorption of isosorbide dinitrate to end-line filters was unimportant but there was a significant loss to the PVC tubing used to connect the filter housing to the catheter.
De Muynck
C
C
Laboratory of Pharmaceutical Technology, State University of Gent, Belgium.
Remon
J P
JP
Colardyn
F
F
D000327:Adsorption; D004349:Drug Packaging; D007262:Infusions, Intravenous; D007275:Injections, Intravenous / Q000295:instrumentation; D007548:Isosorbide Dinitrate / Q000032:analysis*; D013997:Time Factors
D007548:Isosorbide Dinitrate