title: Bivalent ligand type beta-adrenolytics related to practolol.
abstract: The synthesis and pharmacological evaluation of a number of symmetrical bivalent ligand type beta-adrenolytics related to practolol are reported. The best results have been observed with N,N'-bis[3-[2-hydroxy-3-[1-methylethyl)amino]propoxy]phenyl] ethanediamide.
authors.affiliation: Department of Pharmaceutical Sciences, University of Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Rampa
authors.forename: P
authors.initials: P
authors.lastname: Da Re
authors.forename: P
authors.initials: P
authors.lastname: Valenti
authors.forename: V
authors.initials: V
authors.lastname: Frigeni
authors.forename: R
authors.initials: R
authors.lastname: Sala
authors.forename: D
authors.initials: D
authors.lastname: Della Bella
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D015195:Drug Design; D005260:Female; D006168:Guinea Pigs; D007022:Hypotension / Q000139:chemically induced; D007536:Isomerism; D007545:Isoproterenol / Q000037:antagonists & inhibitors; D008297:Male; D011217:Practolol / Q000031:analogs & derivatives* / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013610:Tachycardia / Q000139:chemically induced
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D007545:Isoproterenol; D011217:Practolol