title: Normal phosphatidylcholine composition of lung surfactant 24 hours after inhalation injury.
abstract: The effects of cotton smoke injury on the phosphatidylcholine composition of pulmonary surfactant material were studied. While under halothane anesthesia, 18 ewes were intubated using a double-lumen tube. In six sheep the left lung was exposed to smoke; in another six sheep the right lung was exposed to smoke. A sham group of six sheep was insufflated with air instead of smoke. Twenty-four hours later the animals were killed, and alveolar lavage fluid was obtained from both lungs. Phospholipid material was separated, and its relative phosphatidylcholine composition was determined. In the smoke-treated lungs this composition was not different statistically when compared with the contralateral and the sham-exposed lungs. These findings suggested that smoke inhalation has no effect on the composition of the phosphatidylcholine fraction in the alveolar lining layer 24 hours after injury.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Westfaelische Wilhelms-Universitaet, Muenster, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Prien
authors.forename: W
authors.initials: W
authors.lastname: Strohmaier
authors.forename: H
authors.initials: H
authors.lastname: Gasser
authors.forename: J A
authors.initials: JA
authors.lastname: Richardson
authors.forename: D L
authors.initials: DL
authors.lastname: Traber
authors.forename: G
authors.initials: G
authors.lastname: Schlag
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002059:Burns, Inhalation / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D002302:Cardiac Output; D005260:Female; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D010713:Phosphatidylcholines / Q000378:metabolism*; D012756:Sheep; D013997:Time Factors
chemical_list: D010713:Phosphatidylcholines