Effects of isoprothiolane and phytosterol on serum lipids and adipose tissue of rats given saturated fat diet.
Rats received hardened-tallow (HT) diet continuously for 18 weeks. After 8 weeks of feeding, isoprothiolane (50 mg/kg) or phytosterol (20 mg/kg) was administered orally to the rats once a day consecutively for 10 weeks. In the rats given isoprothiolane, serum high density lipoprotein (HDL) phospholipid concentration increased. Decreased serum very low density lipoprotein (VLDL) cholesterol concentration was seen in the rats given phytosterol. Isoprothiolane increased the level of palmitoleic acid (16:1), while phytosterol increased the level of palmitic acid (16:0) in phospholipid of adipose tissue. In the frozen tissue sections, the multiple crystals were seen in fat cells of the rats fed HT diet. Less crystals were seen in the rats given either drug when compared with the rats fed HT diet without drug.
Katamoto
H
H
Kurihara
S
S
Shimada
Y
Y
D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D004041:Dietary Fats / Q000494:pharmacology*; D005223:Fats / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008297:Male; D008314:Malonates / Q000494:pharmacology*; D010840:Phytosterols / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D004041:Dietary Fats; D005223:Fats; D008055:Lipids; D008314:Malonates; D010840:Phytosterols; C013698:tallow; C024808:diisopropyl 1,3-dithiol-2-ylidenemalonate