title: Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives.
abstract: Some N-(dipeptidyl)-S-acetylcysteamine and N,N'-(dipeptidyl)cystamine salt derivatives were synthesized and evaluated as candidate radioprotector agents. Toxicity and radioprotective activity as the dose reduction factor (DRF) were determined in vivo on mice and compared to N-glycyl-S-acetylcysteamine trifluoroacetate. One of the most interesting compounds of this series was N-glycylglycyl-S-acetylcysteamine trifluoroacetate (8).
authors.affiliation: Laboratoire de Chimie Bio-Organique, U.A. 488 du CNRS, Université des Sciences et Techniques du Languedoc, Montpellier, France.
authors.forename: J
authors.initials: J
authors.lastname: Oiry
authors.forename: J Y
authors.initials: JY
authors.lastname: Pue
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
authors.forename: M
authors.initials: M
authors.lastname: Fatome
authors.forename: H
authors.initials: H
authors.lastname: Sentenac-Roumanou
mesh_terms: D000818:Animals; D003538:Cystamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D003543:Cysteamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology; D051379:Mice; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D004151:Dipeptides; D011837:Radiation-Protective Agents; D003543:Cysteamine; D003538:Cystamine