ins(6;1) in a patient with congenital leukemia.
Q- and C-banded karyotypes of leukemic cells of a patient with congenital acute lymphoblastic leukemia showed the karyotype: 46,XX,ins(6;1)(p21;p13p36). This rearrangement is unusual, and the breakpoints on chromosome 1 are interestingly close to known cellular oncogenes (N-ras, fgr, src-2) and to a putative antioncogene.
Sansone
R
R
Center for Genetic Epidemiology and Oncogenetics, National Cancer Institute, Genova, Italy.
Sessarego
M
M
Haupt
R
R
Garré
M L
ML
Strigini
P
P
D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000151:congenital / Q000235:genetics*; D011519:Proto-Oncogenes