Are most secondary acute lymphoblastic leukemias mixed acute leukemias?
A case of acute lymphoblastic leukemia (ALL) secondary to X-ray exposure is reported. The lymphoblasts expressed T-cell and myelomonocytic differentiation-related surface antigens. Clonal chromosomal abnormalities including t(2;12)(q25;q13),-10,der(10), del(11)(q14),der(12) and r were observed. A review of the cytogenetic data suggests that most secondary ALLs, with the exception of Burkitt type ALLs, may be biphenotypic or mixed acute leukemias.
Chen
S J
SJ
Unité INSERM U 301, CNRS, Paris, France.
Chen
Z
Z
Derré
J
J
Le Coniat
M
M
Valensi
F
F
Sigaux
F
F
Berger
R
R
D000328:Adult; D000943:Antigens, Differentiation / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D015321:Gene Rearrangement; D006650:Histocompatibility Testing; D006801:Humans; D007621:Karyotyping; D015456:Leukemia, Biphenotypic, Acute / Q000209:etiology* / Q000235:genetics; D007953:Leukemia, Radiation-Induced / Q000145:classification* / Q000235:genetics; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification* / Q000209:etiology / Q000235:genetics
D000943:Antigens, Differentiation; D014408:Biomarkers, Tumor