title: [HIV-1 infection: pathogenesis of immune suppression].
abstract: Although, in the course of HIV-1-infection, the functional capacities of virtually all immune cells are greatly impaired, only CD4+ cells (antigen-presenting cells, helper T cells) are directly infected by the virus. CD4+ T cells are involved, to a greater or lesser degree, in the induction of virtually all immunologic phenomena, either directly or indirectly. Thus, it is clear that the HIV-1-induced depletion and functional impairment of this critical T cell subset will result in a dysfunction/deficiency of the entire immune system and, finally, in the development of opportunistic infections and neoplasms.
authors.affiliation: Abteilung für Immunbiologie der Haut, I. Universitäts-Hautklinik Wien.
authors.forename: G
authors.initials: G
authors.lastname: Stingl
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology
vernacular_title: Die HIV-1-Infektion: Pathogenese der Immunsuppression.