title: [DNA analysis by flow cytometry in breast carcinoma].
abstract: Using deparaffinized tumor specimens, a flow cytometric DNA analysis was performed in 63 primary breast cancers from patients who were treated from 1976 through 1982. Fourty-three percent of the cases were found to be aneuploid, and 57% were diploid. No trend to increased aneuploid proportion with a more advanced disease was noted. There was no correlation between the level of ploidy and the clinicopathological factors. Aneuploid tumors seem to have a poorer survival, but no significant difference was found between the two patterns of ploidy. Patients with a low S-phase fraction (SPF) had a significantly longer survival than those with a high SPF. A DNA analysis of the tumor cells in breast cancer is felt to be use for a prognostic evaluation.
authors.affiliation: 2nd Dept. of Surgery, Fukushima Med. College.
authors.forename: A
authors.initials: A
authors.lastname: Tsuchiya
authors.forename: K
authors.initials: K
authors.lastname: Sekikawa
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Ando
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Nihei
authors.forename: Y
authors.initials: Y
authors.lastname: Rokkaku
authors.forename: T
authors.initials: T
authors.lastname: Nomizu
authors.forename: I
authors.initials: I
authors.lastname: Kimijima
authors.forename: R
authors.initials: R
authors.lastname: Abe
mesh_terms: D000782:Aneuploidy; D001943:Breast Neoplasms / Q000032:analysis / Q000401:mortality / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis* / Q000235:genetics; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007399:Interphase; D009367:Neoplasm Staging
chemical_list: D004273:DNA, Neoplasm