Influence of granulocytopenia on canine cerebral ischemia induced by air embolism.
We subjected nine dogs with severe granulocytopenia 4 days after the administration of mechlorethamine to 1 hour of cerebral ischemia induced by the controlled, incremental injection of air into the internal carotid artery. Cortical somatosensory evoked responses and cerebral blood flow determined by [14C]iodoantipyrine autoradiography were compared with those of six control dogs that had received mechlorethamine 1 day previously and were not yet granulocytopenic. Eleven additional control dogs received no mechlorethamine but had identical ischemic insults and were followed for 4 hours after ischemia. Both control groups had identical evoked response outcomes after 1 hour of recovery from ischemia. Granulocytopenic dogs had improved evoked response recoveries compared with either control group after 1 hour of recovery. No areas of very low blood flow were observed 1 hour after ischemia in the granulocytopenic dogs, but three of five dogs in the control group receiving mechlorethamine had such areas.
Dutka
A J
AJ
Diving Medicine Department, Naval Medical Research Institute, Bethesda, Maryland 20814-5055.
Kochanek
P M
PM
Hallenbeck
J M
JM
D000380:Agranulocytosis / Q000139:chemically induced / Q000503:physiopathology*; D000818:Animals; D002545:Brain Ischemia / Q000209:etiology* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D004285:Dogs; D004618:Embolism, Air / Q000150:complications*; D005073:Evoked Potentials, Somatosensory; D002542:Intracranial Embolism and Thrombosis / Q000150:complications*; D008466:Mechlorethamine
D008466:Mechlorethamine