title: Risk factors for glomerular injury in rats with genetic hypertension.
abstract: Systemic and glomerular hypertension, hyperlipidemia, and massive proteinuria have been described as risk factors for the development of focal glomerulosclerosis (FGS). Previous studies have shown that Dahl salt-sensitive (S) rats with severe hypertension have elevated glomerular pressures and develop extensive FGS. In the present study, we determined whether Dahl S rats exhibit other risk factors for FGS. Dahl S rats were found to have elevated serum triglycerides at six weeks of age, compared to Dahl salt-resistant (R) rats. Between six and 24 weeks, systemic hypertension and progressive increases in both serum lipids and albuminuria occurred in Dahl S rats fed high salt (4% NaCl) chow. No changes in blood pressure or serum lipids occurred in Dahl R rats fed high salt. At 30 weeks, the incidence of FGS was 20 times greater in hypertensive Dahl S than in Dahl R. In a separate study, we compared risk factors for FGS in Dahl S rats and spontaneously hypertensive rats (SHR). The magnitude of glomerular capillary pressure, serum lipid levels, and urine albumin excretion were measured in male Dahl S rats and male SHR between 12 and 20 weeks of age. Normal values for the various parameters were established in a group of normotensive male Sprague-Dawley rats. For this study, all rats were fed standard chow containing 0.6% NaCl. Blood pressure was elevated (P less than .01) in Dahl S (142 +/- 2 mm Hg) and in SHR (173 +/- 3 mm Hg) compared to the Sprague-Dawley rats (117 +/- 3 mm Hg). Glomerular capillary pressure, however, was similar in all three groups.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, Hennepin County Medical Center, University of Minnesota, Minneapolis 55415.
authors.forename: M P
authors.initials: MP
authors.lastname: O'Donnell
authors.forename: B L
authors.initials: BL
authors.lastname: Kasiske
authors.forename: W F
authors.initials: WF
authors.lastname: Keane
mesh_terms: D000419:Albuminuria / Q000150:complications; D000818:Animals; D004351:Drug Resistance; D005921:Glomerulonephritis / Q000209:etiology*; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology*; D006949:Hyperlipidemias / Q000150:complications*; D006973:Hypertension / Q000150:complications* / Q000473:pathology; D007678:Kidney Glomerulus; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics; D012307:Risk Factors