Activation and repression of transcription by homoeodomain-containing proteins that bind a common site.
The product of the fushi tarazu (ftz) gene is shown to be a site-dependent activator of transcription. In vitro-defined binding sites act as ftz-dependent enhancers in cultured cells. Another homoeodomain-containing protein, the engrailed gene product, competes for homoeodomain-binding sites and counteracts ftz activation.
Jaynes
J B
JB
Department of Biochemistry and Biophysics, University of California, San Francisco 94143.
O'Farrell
P H
PH
D000818:Animals; D001665:Binding Sites; D002478:Cells, Cultured; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics*; D005786:Gene Expression Regulation; D005801:Genes, Homeobox; D005809:Genes, Regulator; D007301:Insect Hormones; D010957:Plasmids; D014158:Transcription, Genetic
D007301:Insect Hormones