Adverse effects with oral 5-aminosalicyclic acid.
Two patients with ulcerative colitis and a past history of allergic reactions to sulfasalazine had similar reactions when treated with 5-aminosalicylic acid. This suggests that, at least in some patients, the adverse effects of sulfasalazine are due to 5-aminosalicylic acid rather than sulfapyridine. Desensitization to sulfasalazine was successfully carried out in one patient but was not attempted in a second.
Fardy
J M
JM
Department of Medicine, St. Joseph's Health Centre, London, Ontario, Canada.
Lloyd
D A
DA
Reynolds
R P
RP
D000328:Adult; D000636:Aminosalicylic Acids / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity; D004361:Drug Tolerance; D006801:Humans; D008297:Male; D019804:Mesalamine; D008875:Middle Aged; D013427:Sulfapyridine / Q000009:adverse effects; D012460:Sulfasalazine / Q000009:adverse effects / Q000276:immunology
D000636:Aminosalicylic Acids; D012460:Sulfasalazine; D019804:Mesalamine; D013427:Sulfapyridine