title: The Muir-Torre syndrome: a disease of sebaceous and colonic neoplasms.
abstract: The Muir-Torre syndrome of sebaceous neoplasms of the skin, with or without keratoacanthomas, and multiple low-grade visceral malignancies with prolonged survival is a rare disorder. Colonic polyps are frequently present, and the syndrome appears to be familial. We report 2 unrelated patients with the Muir-Torre syndrome. Each case exhibited sebaceous adenomas. Gastrointestinal findings included colonic adenocarcinomas and a tubulovillous adenoma. Although an unusual disease, the Muir-Torre syndrome requires recognition because these patients are at risk for multiple primary malignancies and may have family members also at risk.
authors.affiliation: Department of Dermatology, New Jersey Medical School, Newark.
authors.forename: R A
authors.initials: RA
authors.lastname: Schwartz
authors.forename: D J
authors.initials: DJ
authors.lastname: Goldberg
authors.forename: F
authors.initials: F
authors.lastname: Mahmood
authors.forename: R L
authors.initials: RL
authors.lastname: DeJager
authors.forename: W C
authors.initials: WC
authors.lastname: Lambert
authors.forename: A Z
authors.initials: AZ
authors.lastname: Najem
authors.forename: P J
authors.initials: PJ
authors.lastname: Cohen
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000236:Adenoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics*; D005153:Facial Neoplasms / Q000235:genetics; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology; D012626:Sebaceous Gland Neoplasms / Q000235:genetics* / Q000473:pathology; D012627:Sebaceous Glands / Q000473:pathology; D013577:Syndrome