title: Frequency-dependent selection, metrical characters and molecular evolution.
abstract: Computer models of selection acting on a quantitative character show that a combination of frequency-dependent and stabilizing selection can maintain many polymorphisms among the genes that determine the character. The models also show that the random order of mutations can give rise to selectively driven stochastic effects that are sometimes more important than random genetic drift. They suggest simple explanations for patterns of divergence between populations and species, and for apparent discrepancies between the rates of morphological and molecular evolution. They point towards a selective theory of 'molecular clocks'.
authors.affiliation: Department of Genetics, Queen's Medical Centre, Nottingham, U.K.
authors.forename: B C
authors.initials: BC
authors.lastname: Clarke
authors.forename: P R
authors.initials: PR
authors.lastname: Shelton
authors.forename: G S
authors.initials: GS
authors.lastname: Mani
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001717:Birds / Q000235:genetics; D005787:Gene Frequency; D008433:Mathematics; D008957:Models, Genetic; D009154:Mutation; D010641:Phenotype; D012641:Selection, Genetic