[The proliferative potential of hematopoietic stem cells (CFUs) during serial passage in irradiated mice as foci of ectopic hematopoiesis].
During serial passages of hemopoietic tissue as a whole ectopic hemopoietic site under renal capsule of irradiated mice gradual decrease of proliferative potential of CFUs has been observed. The results suggest that the most probable cause of such decline is random loss of precursor cells with high but limited proliferative potential during serial passages of hemopoietic tissue.
Deriugina
E I
EI
Drize
N I
NI
Udalov
G A
GA
Chertkov
I L
IL
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002455:Cell Division / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D005260:Female; D006411:Hematopoiesis, Extramedullary / Q000528:radiation effects*; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000528:radiation effects*; D007668:Kidney; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D014185:Transplantation, Isogeneic
Proliferativnyĭ potentsial stvolovykh krovetvornykh kletok (KOEc), seriĭno passiruemykh v obluchennykh myshakh v sostave ochagov éktopicheskogo krovetvoreniia.