Structural basis for antiviral activity of flavonoids-naturally occurring compounds.
The effect of different substituents of quercetin and luteolin on the ability to inhibit the herpes simplex virus (HSV-1) replication in RK-13 cells was studied. It seems that parent compounds with free hydroxyl groups at C-5, C-7, C-3', C-4' and additionally at C-3 have the highest activity. Substitution of those groups caused decrease of or completely abolished the antiviral activity of the tested compounds.
Wleklik
M
M
Department of Virology Institute of Biostructure Medical Academy of Warsaw, Poland.
Luczak
M
M
Panasiak
W
W
Kobus
M
M
Lammer-Zarawska
E
E
D002460:Cell Line; D005419:Flavonoids / Q000494:pharmacology*; D047311:Luteolin; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
D005419:Flavonoids; D011794:Quercetin; D047311:Luteolin