Physiology of IgD. VI. Transfer of the immunoaugmenting effect of IgD with T delta-containing helper cell populations.
We show that the IgD-induced augmentation of the immune response to trinitrophenylated keyhole limpet hemocyanin can be transferred to syngeneic mice with spleen cells from IgD-injected donors. The augmenting activity is present in the Lyt-1+2-, L3T4+ T cell population and is absent from B cells. The ability of transferred T cells to augment the immune response correlates with the presence of a high frequency of Lyt-1+2- T cells that form rosettes with IgD-coated sheep erythrocytes (T delta cells). Such rosette-forming cells can also be induced by incubation of spleen cells from normal donors in IgD-coated petri dishes. Injection of normal spleen cells exposed to IgD-coated petri dishes together with antigen also augments the immune response of recipients. The existence of a regulatory circuit based upon interactions between T delta cells, antigen, B cell surface IgD, and serum IgD, is proposed.
Coico
R F
RF
Xue
B
B
Wallace
D
D
Siskind
G W
GW
Thorbecke
G J
GJ
D000276:Adjuvants, Immunologic / Q000502:physiology*; D000818:Animals; D006241:Haptens / Q000008:administration & dosage / Q000276:immunology; D006433:Hemocyanins / Q000008:administration & dosage / Q000276:immunology; D007116:Immunization, Passive; D007072:Immunoglobulin D / Q000008:administration & dosage / Q000502:physiology*; D007275:Injections, Intravenous; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D011948:Receptors, Antigen, T-Cell / Q000096:biosynthesis; D011961:Receptors, Fc / Q000096:biosynthesis; D012397:Rosette Formation; D013045:Species Specificity; D006377:T-Lymphocytes, Helper-Inducer / Q000145:classification / Q000276:immunology* / Q000378:metabolism; D014301:Trinitrobenzenes / Q000008:administration & dosage / Q000276:immunology
D000276:Adjuvants, Immunologic; C037317:Fc(delta) receptor; D006241:Haptens; D007072:Immunoglobulin D; D011948:Receptors, Antigen, T-Cell; D011961:Receptors, Fc; D014301:Trinitrobenzenes; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin