[Changes in sensitivity of lymphocyte cholinergic receptors in patients with breast cancer].
Alteration of the cholinoreceptor sensitivity of peripheral blood lymphocytes in patients with breast cancer was studied by the lymphocyte adhesion inhibition test (LAI-test). It has been shown that acetylcholine stimulates the LAI-reaction in optimal concentrations of 10(-7)-10(-8) M. Specific antagonists (m-cholinoblocker of atropin and n-cholinoblocker of hexonium) being used, it is demonstrated that the revealed cholinergic enhancement of the lymphocyte adherence inhibition is mediated through the stimulating influence of acetylcholine on m-cholinoreceptors. It is established that the lymphocyte cholinoreceptor sensitivity of the patients with breast cancer at the advanced stages is significantly lower than in patients with breast cancer at early stages.
Kharkevich
D D
DD
Polevaia
E B
EB
D000109:Acetylcholine / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D001943:Breast Neoplasms / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006801:Humans; D007957:Leukocyte Adherence Inhibition Test; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology
D006584:Hexamethonium Compounds; D011950:Receptors, Cholinergic; D018738:Hexamethonium; D001285:Atropine; D000109:Acetylcholine
Izmenenie kholinoretseptornoĭ chuvstvitel'nosti limfotsitov krovi bol'nykh rakom molochnoĭ zhelezy.