title: Early lesions and natural progression of bladder carcinoma (minute bladder carcinoma).
abstract: Morphological analyses of minute bladder carcinomas (less than 5mm in diameter) and their natural progression to advanced carcinomas were examined. There were 71 minute carcinomas in 25 cases, the highest number in any one case being eight. The growth forms of the 71 minute carcinomas were classified into six types: papillary (35), Brunn's nest-like (20), intermediate between those two (9), simple displacing (3), inverted papillary (2) and invasive (2). There appeared to be two kinds of advanced papillary carcinoma, one forming a papillary tumor from the onset of progression, and the other, initially exhibiting Brunn's nest-like, intermediate or simple displacing tumors and finally forming papillary tumors. Some of the papillary carcinomas seemed to have developed from papillomas. Two pathways to invasive carcinomas from papillary tumor were suggested: one showing invasive growth directly from the papillary tumor, the other developing invasive changes in the proliferative processes from Brunn's nest-like or intermediate tumors. Invasive growths occurred in tumors of G2 or over and in those in which the character of the tumor was changed to that of squamous cell carcinoma. They appeared to be more frequent (four cases out of 13 compared with one out of 10) in the advanced papillary carcinomas which had seemingly developed from the various kinds of minute tumor other than papillary. Invasive minute carcinoma was regarded as being an early stage of advanced non-papillary invasive carcinoma.
authors.affiliation: Pathology Division, National Cancer Center Hospital, Tokyo.
authors.forename: K
authors.initials: K
authors.lastname: Kishi
authors.forename: T
authors.initials: T
authors.lastname: Kakizoe
authors.forename: K
authors.initials: K
authors.lastname: Tobisu
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Niizuma
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010212:Papilloma / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000473:pathology*