Activation in vivo of a major antisuppressor T-cell pathway immediately after immunization. I. Its regulation by I-A gene products.
It has previously been demonstrated that within 6 hr after immunogenic stimulation the serum of mice contains a unique form of immunogenic antigen which represents complexes of Ig and antigen. The complexes are known to be strongly cytophilic for Ly2+ Ia+ FcR+ T cells and markedly enhance the IgG response. Anti-I-A treatment of mice suppresses the IgG antibody response and results in the generation of antigen specific T suppressor cells (Ts). Furthermore, anti-I-A treatment blocks the induction of the complexes and abolishes the enhancing effect the complexes exert on the IgG antibody response. The 6-hr cytophilic complexes were shown to block the function of Ts and allow a normal IgG response to take place; therefore, they act as mediators of a novel T-cell pathway called antisuppression. The blocking of the induction of the antisuppressor complexes by anti-I-A antibody was at least in part due to an effect on T cells. In conclusion, products of genes of the I-A subregion of the MHC control the activation early after immunization of a T-cell pathway which is called antisuppression since its major function is interference with the expression of suppression. Its early induction (within 6 hr) suggests that antisuppression may play a pivotal role in determining between immunity and unresponsiveness.
Paraskevas
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Lee
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Maeba
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David
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CS
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000502:physiology; D001667:Binding, Competitive; D001798:Blood Proteins / Q000096:biosynthesis / Q000502:physiology; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000276:immunology; D007108:Immune Tolerance; D007116:Immunization, Passive; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology*; D013997:Time Factors
D000911:Antibodies, Monoclonal; D001798:Blood Proteins; D000949:Histocompatibility Antigens Class II; C011850:immunoenhancing factor