Effect of thyroid hormone on somatomedin-C release from perfused rat liver.
The effect of thyroid hormone on plasma somatomedin-C (SmC) level and on SmC release from perfused rat liver was investigated. Plasma SmC levels and liver tissue SmC were significantly increased in thyroxine-treated rats. Physiological doses of triiodothyronine increased SmC release and SmC concentration in the perfused rat liver. These results indicate that thyroid hormone directly enhances the synthesis and release of SmC in the rat.
Ikeda
T
T
First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
Fujiyama
K
K
Takeuchi
T
T
Honda
M
M
Mokuda
O
O
Tominaga
M
M
Mashiba
H
H
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D007334:Insulin-Like Growth Factor I / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010477:Perfusion; D051381:Rats; D013002:Somatomedins / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood / Q000494:pharmacology*; D014284:Triiodothyronine / Q000097:blood / Q000494:pharmacology*
D013002:Somatomedins; D014284:Triiodothyronine; D007334:Insulin-Like Growth Factor I; D013974:Thyroxine