Relationship of adverse drug reactions to length of hospital-stay in genetically subgrouped schizophrenics.
The emergence of depression, parkinsonism, and akathisia after neuroleptic therapy was associated with increased length of hospital-stay in schizophrenics with affective heredity only. In schizophrenics with schizophrenic heredity, increased length of hospital-stay was associated with residual hallucinations and apathy. In the former patients, findings were theoretically attributed to a putative biogenetic abnormality sensitive to the effects of neuroleptic drugs.
Galdi
J
J
Biometric Laboratory, George Washington University, Kensington, Maryland.
Bonato
R R
RR
D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002746:Chlorpromazine / Q000009:adverse effects; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000139:chemically induced / Q000235:genetics*; D004311:Double-Blind Method; D004409:Dyskinesia, Drug-Induced / Q000235:genetics; D005476:Fluphenazine / Q000009:adverse effects; D006801:Humans; D007902:Length of Stay; D010546:Perphenazine / Q000009:adverse effects; D011897:Random Allocation; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D010546:Perphenazine; D005476:Fluphenazine; D002746:Chlorpromazine