Effect of epidural lidocaine on spinal cord blood flow.
The effect of epidural lidocaine on spinal cord blood flow (SCBF) was measured in mongrel dogs. Spinal evoked potentials were used to measure spinal cord conduction and enabled us to time the measurement of SCBF associated with maximum reduction in latency and amplitude of spinal evoked potentials produced by instillation of 5 ml of 2% lidocaine in the epidural space. We used the radioactive microsphere technique to quantitate SCBF in the cervical, upper thoracic, lower thoracic, and lumbar regions of the spinal cord. A narcotic/relaxant technique was used to eliminate SCBF changes associated with other anesthetic agents. Other parameters known to affect SCBF were kept constant and within normal physiologic values. As compared with saline solution controls, there were significant decreases in SCBF in all the four areas of spinal cord in animals given epidural lidocaine, most marked in the lumbar area.
Mitchell
P
P
Department of Anesthesiology, F.G. Hall Environmental Laboratory, Duke University Medical Center, Durham, NC 27710.
Goad
R
R
Erwin
C W
CW
Camporesi
E M
EM
Moon
R E
RE
Watkins
W D
WD
Bennett
P B
PB
D000767:Anesthesia, Epidural; D000818:Animals; D004285:Dogs; D007268:Injections, Epidural; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D013116:Spinal Cord / Q000098:blood supply*; D014661:Vasoconstriction / Q000187:drug effects
D008012:Lidocaine