title: Central adiposity and gallbladder disease in Mexican Americans.
abstract: Obesity is widely recognized as a risk factor for gallstones. However, to the authors' knowledge, only one study has examined the effect of body fat distribution on the prevalence of gallbladder disease. Mexican Americans are a population characterized by both a high prevalence of gallbladder disease and an unfavorable body fat distribution. The authors examined whether central adiposity (as measured by the ratio of subscapular-to-triceps skinfold) was related to clinically evident gallbladder disease in 1,202 Mexican Americans and 908 non-Hispanic whites in the San Antonio Heart Study from 1979 to 1982. After adjustment for overall adiposity (as measured by body mass index) and the ratio of subscapular-to-triceps skinfold, an increased prevalence of gallbladder disease was still observed in Mexican-American women. Both body mass index and the ratio of subscapular-to-triceps skinfold were positively and independently associated with gallbladder disease in women, while in men, body mass index, but not the subscapular-to-triceps skinfold ratio, was associated with gallbladder disease. Central adiposity is also related to the adverse pattern of cardiovascular risk factors observed in women with gallbladder disease.
authors.affiliation: U. of Texas Health Science Center, San Antonio 78284.
authors.forename: S M
authors.initials: SM
authors.lastname: Haffner
authors.forename: A K
authors.initials: AK
authors.lastname: Diehl
authors.forename: M P
authors.initials: MP
authors.lastname: Stern
authors.forename: H P
authors.initials: HP
authors.lastname: Hazuda
mesh_terms: D000328:Adult; D000367:Age Factors; D004812:Epidemiologic Methods; D005260:Female; D005705:Gallbladder Diseases / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008800:Mexico / Q000208:ethnology; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000208:ethnology; D012737:Sex Factors; D012885:Skinfold Thickness; D013781:Texas