title: [Topographic distribution of proliferating hepatocytes in the hepatic lobe of intact rats during the course of 24 hours].
abstract: The topographic distribution of DNA-synthesizing and divisible hepatocytes was studied in the hepatic lobe of intact rats during the 24-hours. For this purpose the indices of a number of DNA-synthesizing and divisible cells were determined both in a liver as a whole and for each lobe zone (periportal, middle and central one). The obtained results allowed to reveal the presence of the 24-hour rhythm of cell proliferation process in a liver as well as the regular topographic distribution of DNA-synthesizing and divisible hepatocytes during the period of their increased values in the rhythm. The process of activation of proliferation seems to start in the periportal zone, and then to hold the whole zone, with its dominance in the middle zone during the period of maximum values of the cell proliferation indices. One could suppose that this testifies to the equal proliferative potencies of hepatocytes irrespective of their localization as well as to the fact that the cells of all zones take part in the formation of acrophases of rhythms both of the DNA-synthesizing hepatocytes and divisible ones. However, the degree of their participation in this process is unequal and depends on the localization of cells in the hepatic lobe.
authors.forename: T V
authors.initials: TV
authors.lastname: Savchenko
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Romanov
mesh_terms: D000818:Animals; D002455:Cell Division; D002940:Circadian Rhythm; D004247:DNA / Q000096:biosynthesis; D008099:Liver / Q000166:cytology* / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D008938:Mitosis; D051381:Rats; D014316:Tritium
chemical_list: D014316:Tritium; D004247:DNA
vernacular_title: Topograficheskoe raspredelenie proliferiruiushchikh gepatotsitov v dol'ke pecheni intaktnykh krys na protiazhenii sutok.