title: The effect of radiation on the fracture repair process. A biomechanical evaluation of a closed fracture in a rat model.
abstract: The effects of a single dose of irradiation on the biomechanical parameters of the fracture healing process were studied in a rat model. Intramedullary pinning was performed before production of a closed femoral midshaft fracture. The experimental group was exposed to 900 rad 3 days after fracture and was compared with a control group with a similar fracture that received no irradiation. Animals were killed at intervals ranging from 2-16 weeks after surgery and the bones were tested until failure in torsion. In the irradiated groups, a delay of 4 weeks was noted in the biomechanical parameters associated with fracture healing (torque to failure, torsional stiffness, angle to failure, and biomechanical stage). Despite this delay in the normal temporal progression, the staging and stiffness approached normal controls within an 8-week period. However, the torque to failure remained below normal levels at the conclusion of this study. These results differ from a previous study using an open fracture model.
authors.affiliation: Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06510.
authors.forename: L A
authors.initials: LA
authors.lastname: Markbreiter
authors.forename: R R
authors.initials: RR
authors.lastname: Pelker
authors.forename: G E
authors.initials: GE
authors.lastname: Friedlaender
authors.forename: R
authors.initials: R
authors.lastname: Peschel
authors.forename: M M
authors.initials: MM
authors.lastname: Panjabi
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001858:Bone Nails; D002146:Bony Callus / Q000528:radiation effects; D005260:Female; D005264:Femoral Fractures / Q000503:physiopathology*; D005596:Fractures, Closed / Q000503:physiopathology*; D011829:Radiation Dosage; D051381:Rats; D011919:Rats, Inbred Strains; D014945:Wound Healing / Q000528:radiation effects*