Family screening in medullary thyroid carcinoma presenting without a family history.
Systematic screening of the families of a series of 39 patients with apparently sporadic medullary thyroid carcinoma detected seven new cases in four families. A negative family history in a patient presenting with medullary thyroid carcinoma is not reliable in excluding familial disease, and family screening should be considered for new patients with medullary thyroid carcinoma.
Ponder
B A
BA
Royal Marsden Hospital, Sutton, Surrey.
Finer
N
N
Coffey
R
R
Harmer
C L
CL
Maisey
M
M
Ormerod
M G
MG
Pembrey
M E
ME
Ponder
M A
MA
Rosswick
P
P
Shalet
S
S
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000175:diagnosis / Q000235:genetics*; D002648:Child; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000175:diagnosis* / Q000235:genetics; D010375:Pedigree; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics*