Brain cholecystokinin depletion in rats with acute liver failure.
A decrease of both hypothalamic and cortical CCK occurred in the brain of rats killed 8 hours after hepatic artery ligation following portocaval anastomosis. Brain CCK depletion was not reproduced by exogenously provoked hyperammonemia nor by insulin-induced hypoglycemia, thus suggesting a central mechanism for the derangement of the CCKergic system in the course of acute liver failure.
Bonato
C
C
Instituti di Medicina Interna e di Clinica Chirurgica I, Ospedale Policlinico-Università di Milano, Italy.
Malesci
A
A
Rosati
R
R
Vignati
F
F
Montorsi
M
M
Bersani
M
M
Abbiati
R
R
Salerno
F
F
D000641:Ammonia / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D002766:Cholecystokinin / Q000378:metabolism*; D004195:Disease Models, Animal; D007031:Hypothalamus / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D000641:Ammonia; D002766:Cholecystokinin