Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.
Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans-encoded HLA-DQ alpha/beta heterodimer.
Sollid
L M
LM
Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.
Markussen
G
G
Ek
J
J
Gjerde
H
H
Vartdal
F
F
Thorsby
E
E
D002446:Celiac Disease / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D015345:Oligonucleotide Probes
D006683:HLA-DQ Antigens; D015345:Oligonucleotide Probes