title: Cerebral metabolism in hyper- and hypocarbia: 31P and 1H nuclear magnetic resonance studies.
abstract: Paralyzed rabbits ventilated with an oxygen, nitrous oxide, and carbon dioxide mixture were subjected to hyper- and hypocarbic stress. An Oxford Instrument TMR 32-200 spectrometer was used to record phosphorus-31 and nonwater proton nuclear magnetic resonance spectra of the in vivo brain. These spectra provide measurements of cerebral pHi, phosphocreatine, orthophosphate, ATP, and lactate. The brain exhibited twice as much acute pH-regulating ability as the arterial blood. During hypercarbia, orthophosphate rose while phosphocreatine declined in a reciprocal manner, and ATP remained constant. During hypocarbia, lactate rose gradually over a period of 1 hour, while orthophosphate, phosphocreatine, and ATP remained constant and calculated values of adenosine mono- and diphosphate rose.
authors.forename: O A
authors.initials: OA
authors.lastname: Petroff
authors.forename: J W
authors.initials: JW
authors.lastname: Prichard
authors.forename: K L
authors.initials: KL
authors.lastname: Behar
authors.forename: D L
authors.initials: DL
authors.lastname: Rothman
authors.forename: J R
authors.initials: JR
authors.lastname: Alger
authors.forename: R G
authors.initials: RG
authors.lastname: Shulman
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002245:Carbon Dioxide / Q000032:analysis*; D005260:Female; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D010732:Phosphofructokinase-1 / Q000378:metabolism; D010758:Phosphorus; D011817:Rabbits
chemical_list: D002245:Carbon Dioxide; D010758:Phosphorus; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D010732:Phosphofructokinase-1