The initiator tRNA acceptance assay as a short-term test for carcinogens. 4. Results with 20 mycotoxins.
The activity of 20 mycotoxins was tested by the recently developed initiator tRNA acceptance assay for carcinogens. With the exception of citrinin, all compounds carcinogenic for rodents stimulated the charging of tRNA with L-methionine. In three out of four non-carcinogenic mycotoxins the test was negative. Five carcinogenic mycotoxins were negative in mutagenicity tests but positive in the acceptance assay indicating that also non-mutagenic carcinogens may be detected by the latter procedure.
Hradec
J
J
Department of Molecular Biology, Research Institute for Tuberculosis and Respiratory Diseases, Prague, Czechoslovakia.
Veselý
D
D
D015197:Carcinogenicity Tests; D066298:In Vitro Techniques; D009183:Mycotoxins / Q000633:toxicity*; D010442:Peptide Chain Initiation, Translational; D012345:RNA, Transfer, Amino Acid-Specific / Q000378:metabolism*; D012358:RNA, Transfer, Met / Q000378:metabolism*; D046249:Transfer RNA Aminoacylation / Q000187:drug effects
D009183:Mycotoxins; D012345:RNA, Transfer, Amino Acid-Specific; D012358:RNA, Transfer, Met