Reversal of neuroleptic-induced catalepsy by novel aryl-piperazine anxiolytic drugs.
The novel anxiolytic drug, buspirone, reverses catalepsy induced by haloperidol. A series of aryl-piperazine analogues of buspirone and other 5-hydroxytryptaminergic agonists were tested for their ability to reverse haloperidol induced catalepsy. Those drugs with strong affinity for 5-hydroxytryptamine1a receptors were able to reverse catalepsy. Drugs with affinity for other 5-HT receptors or weak affinity were ineffective. However, inhibition of postsynaptic 5-HT receptors neither inhibited nor potentiated reversal of catalepsy and leaves open the question as to the site or mechanism for this effect.
McMillen
B A
BA
Department of Pharmacology, School of Medicine, East Carolina University, Greenville 27858.
Scott
S M
SM
Davanzo
E A
EA
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy*; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D010869:Pindolol / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats
D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D010879:Piperazines; D009020:Morphine; D010869:Pindolol; D006220:Haloperidol; D008784:Methysergide