title: Experimental dissociation of food intake and plasma beta-endorphin following 2-deoxy-D-glucose in rats.
abstract: The present studies were undertaken to further assess the role of plasma beta-endorphin (beta-EP) in the hyperphagia induced by the glucose antimetabolite, 2-deoxy-D-glucose (2-DG). Plasma concentrations of immunoreactive beta-EP (ir-beta-EP) were measured at the end of the first hour of feeding in all animals treated with 400 mg/kg 2-DG. Previous studies had shown a consistent, positive association between 2-DG hyperphagia and plasma ir-beta-EP concentrations, but the present data revealed dissociations between hyperphagia and plasma ir-beta-EP. Dexamethasone administration blocked the 2-DG-induced rise in plasma ir-beta-EP, but had no effect on the 2-DG hyperphagia measured at 1 hour. Forced drinking of a 2% NaCl solution decreased 2-DG hyperphagia, but not the 2-DG induced rise in plasma ir-beta-EP. Thus, elevations in plasma ir-beta-EP are not necessary for the full expression of 2-DG-induced hyperphagia in dexamethasone-treated rats. Furthermore, decreased feeding responses to 2-DG could coexist with increased levels of plasma ir-beta-EP in NaCl-treated normal rats. Elevations in plasma ir-beta-EP do not appear to be the critical opiate link in 2-DG induced hyperphagia.
authors.forename: M T
authors.initials: MT
authors.lastname: Lowy
authors.forename: J M
authors.initials: JM
authors.lastname: Davis
authors.forename: D R
authors.initials: DR
authors.lastname: Lamb
authors.forename: P V
authors.initials: PV
authors.lastname: Malven
authors.forename: G K
authors.initials: GK
authors.lastname: Yim
mesh_terms: D000818:Animals; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology; D004723:Endorphins / Q000097:blood*; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D001615:beta-Endorphin
chemical_list: D003837:Deoxy Sugars; D004723:Endorphins; D012462:Saline Solution, Hypertonic; D001615:beta-Endorphin; D003907:Dexamethasone; D003847:Deoxyglucose