Monozygotic twins concordant for the narcoleptic syndrome.
We report the first documented monozygotic twins who both had the narcoleptic syndrome. We assessed monozygosity by HLA antigens and by blood groups. In contrast to virtually all other narcoleptics, they had HLA-DQ1 instead of HLA-DR2; this helped to localize the gene, and perhaps explains its greater expressivity in these than in other twins.
Douglass
A B
AB
Faculty of Medicine, University of Alberta, Edmonton, Canada.
Harris
L
L
Pazderka
F
F
D000293:Adolescent; D004200:Diseases in Twins; D006680:HLA Antigens / Q000032:analysis / Q000145:classification; D006801:Humans; D008297:Male; D009207:Myoclonus / Q000150:complications / Q000503:physiopathology; D009290:Narcolepsy / Q000150:complications / Q000235:genetics* / Q000276:immunology; D013577:Syndrome; D014427:Twins; D014430:Twins, Monozygotic
D006680:HLA Antigens