Taq I polymorphism of HLA class I genes in an ankylosing spondylitis family.
A 3.5-kb HLA class I fragment is polymorphic in an ankylosing spondylitis (AS) family. All B27 AS patients show the 3.5-kb band, which is also present in B12 AS patients in this family. When hybridized with an HLA-B-specific probe, the polymorphic band is revealed in B12 patients, but not in B27 patients.
Lucotte
G
G
Laboratory of Molecular Genetics, National Blood Transfusion Center Institute, Paris, France.
Huetz
F
F
Mariotti
M
M
Cavelier
B
B
Deshayes
P
P
Amor
B
B
D000483:Alleles; D015342:DNA Probes; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D015698:Genomic Library; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000276:immunology
D015342:DNA Probes; D006680:HLA Antigens; D015235:HLA-B Antigens; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases