An experimental animal model of Kashin-Beck disease.
Twelve young macaque monkeys were fed with grain and water from areas actively endemic or non-endemic for Kashin-Beck disease. Both dietary grain and water from geographical areas endemic for Kashin-Beck disease induced a sequence of pathological changes in the growth plates and articular cartilage and biochemical changes in the serum and urine of monkeys. These changes are similar to those in human Kashin-Beck disease. It is considered that this may be a simple and valuable model for the further study of this disease and its management and control. The results suggest that the pathogenetic factors of Kashin-Beck disease relate both to grain and to water in the diet in endemic areas. The experiment also shows that certain serum enzyme concentrations correlate with chondronecrosis.
Zhang
G Q
GQ
Heilong Jian Institute of Kashin-Beck Disease, Harbin Medical College, China.
Liu
J X
JX
D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology; D004195:Disease Models, Animal; D002523:Edible Grain / Q000633:toxicity; D005260:Female; D006132:Growth Plate / Q000473:pathology; D008251:Macaca; D008297:Male; D010003:Osteoarthritis / Q000201:enzymology / Q000209:etiology* / Q000473:pathology; D014867:Water
D014867:Water