Resveratrol activity on guinea pig isolated trachea from normal and albumin-sensitized animals.
The relaxant effect of resveratrol on guinea pig isolated trachea (EC50 = 100 microM) was not due to interactions with histaminergic or cholinergic systems, but appeared to be influenced by beta-blockers, indomethacin and mepacrine. Antigen-induced contraction on sensitized trachea was partially antagonized by resveratrol. Resveratrol action may be partially related to arachidonic acid metabolism.
Ragazzi
E
E
Department of Pharmacology, University of Padua, Padova, Italy.
Froldi
G
G
Fassina
G
G
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D004983:Ethanolamines / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D007114:Immunization; D066298:In Vitro Techniques; D008297:Male; D009637:Masoprocol / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D010047:Ovalbumin; D011433:Propranolol / Q000494:pharmacology; D011796:Quinacrine / Q000494:pharmacology; D000077185:Resveratrol; D013267:Stilbenes / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D004983:Ethanolamines; D013267:Stilbenes; D009637:Masoprocol; D010047:Ovalbumin; D011433:Propranolol; C100250:nifenalol; D011796:Quinacrine; D000077185:Resveratrol