title: Massive pericellular collagen deposition in the liver of a young female with severe Crohn's disease.
abstract: We report a patient with Crohn's disease in whom repeated liver biopsies taken at surgery for the bowel disease showed progressive hepatic fibrosis of an unusual type. Dense collagen was deposited in the perisinusoidal space often surrounding individual hepatocytes. The aetiology and pathogenesis of this abnormality remain speculative.
authors.affiliation: TNO Institute for Experimental Gerontology, Rijswijk, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Bosma
authors.forename: S G
authors.initials: SG
authors.lastname: Meuwissen
authors.forename: B H
authors.initials: BH
authors.lastname: Stricker
authors.forename: A
authors.initials: A
authors.lastname: Brouwer
mesh_terms: D000328:Adult; D003094:Collagen / Q000378:metabolism*; D003424:Crohn Disease / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D008103:Liver Cirrhosis / Q000150:complications / Q000378:metabolism / Q000473:pathology*
chemical_list: D003094:Collagen