title: An association between parameters of liver blood flow and percentage hepatic replacement with tumour.
abstract: The extent of hepatic replacement with tumour is a significant prognostic factor in patients with liver metastases. Measuring the percentage hepatic replacement (PHR) accurately is difficult, but is important for both patient management and clinical trial evaluation. This study correlates haemodynamic indices obtained by dynamic liver scintigraphy (DLS) with estimates of PHR made from isotope scan, ultrasound, CT scan and laparotomy in 45 patients with established colorectal liver metastases and 21 controls who also underwent DLS. There was a significant reduction in the mesenteric fraction (MF) in the group of patients with metastases compared to the controls (P less than 0.001), and also a significant trend for progressive reduction in the MF with increasing PHR. A significant rise in an index of total hepatic arterial blood flow was also demonstrated with increasing PHR. These results are important with current interest in regional hepatic arterial therapy, and may prove of clinical value for prediction or monitoring of response to therapy.
authors.affiliation: University Surgical Unit, Department of Nuclear Medicine, Southampton General Hospital, UK.
authors.forename: T M
authors.initials: TM
authors.lastname: Hunt
authors.forename: A D
authors.initials: AD
authors.lastname: Flowerdew
authors.forename: A J
authors.initials: AJ
authors.lastname: Britten
authors.forename: J S
authors.initials: JS
authors.lastname: Fleming
authors.forename: S J
authors.initials: SJ
authors.lastname: Karran
authors.forename: I
authors.initials: I
authors.lastname: Taylor
mesh_terms: D015179:Colorectal Neoplasms; D006801:Humans; D008099:Liver / Q000473:pathology*; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000556:secondary*; D011379:Prognosis; D013152:Splanchnic Circulation