Feasibility of placental biopsy in the second trimester for fetal diagnosis.
Second-trimester prenatal diagnosis by placental biopsy was possible in 200 of 220 patients (90.9%) to whom it was offered to expedite cytogenetic analysis. Cytogenetic analysis was successful in 190 cases (95%) when the material obtained was greater than 2 mg. We found five chromosome abnormalities; 47,XX, +21 (two cases); 47,XY, +18 (one case); and 45,XX,t (D;G) (two cases). There was one abortion 4 weeks after the placental biopsy (0.4%). If further experience confirms the accuracy, safety, and reliability of this method beyond the first trimester, it can be offered to mothers to expedite the cytogenetic, biochemical, and deoxyribonucleic acid analysis.
Chieri
P R
PR
Consultorio de Diagnóstico Genético, Buenos Aires, Argentina.
Aldini
A J
AJ
D000328:Adult; D001707:Biopsy, Needle; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D010865:Pilot Projects; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis / Q000379:methods*