title: Tumor-infiltrating lymphocytes and histocompatibility antigens in primary intracranial germinomas.
abstract: Subpopulations of tumor-infiltrating lymphocytes (TIL's) and the major histocompatibility complex (MHC) antigens of neoplastic cells were examined in three intracranial germinomas by an immunohistochemical method using monoclonal antibodies. About 70% to 80% of TIL's were T lymphocytes which were either infiltrating diffusely or in clusters, whereas 20% to 30% of TIL's were B lymphocytes which tend to cluster in tumor tissues. Examination of T lymphocyte phenotypes revealed both the cytotoxic/suppressor and helper/inducer T lymphocytes, as in other tumors. However, the existence of a considerable number of B lymphocytes in the TIL population was uncommon and seemed to be a characteristic feature of the intracranial germinoma, which might suggest a difference of host immune response to this neoplasm as compared to other tumors. On examination of the MHC antigens, no MHC class I or II antigens in the neoplastic cells were stained, while positive staining for both antigens was seen in the TIL and stroma tissues. From these findings, it was suggested that the degree of TIL infiltration might not be correlated with the expression of MHC antigens in neoplastic cells in cases of primary intracranial germinoma.
authors.affiliation: Department of Neurosurgery, Brain Research Institute, Niigata University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: R
authors.initials: R
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Kouno
authors.forename: K
authors.initials: K
authors.lastname: Washiyama
authors.forename: S
authors.initials: S
authors.lastname: Abe
authors.forename: T
authors.initials: T
authors.lastname: Kumanishi
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000276:immunology / Q000473:pathology*; D004407:Dysgerminoma / Q000276:immunology / Q000473:pathology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000145:classification / Q000502:physiology*; D008297:Male; D010641:Phenotype
chemical_list: D006680:HLA Antigens