title: Clinical response and survival according to estrogen receptor levels after bilateral ovariectomy in advanced breast cancer.
abstract: Estrogen receptor levels were determined at the time of ovariectomy in 71 premenopausal women with advanced breast cancer. Three groups of estrogen receptor concentration were established: less than 10 fmol/mg cytosol protein (group 1), between 10 and 25 fmol/mg cytosol protein (group 2), and more than 25 fmol/mg cytosol protein (group 3). The frequency of clinical response to ovariectomy was low in group 1 (17.4%), high in group 3 (79.4%), and intermediate in group 2 (35.7%). Median survival was poor in group 1 (18.5 months) and better in groups 2 (33.0 months) and 3 (32.5 months). These results were independent of disease stage and neoplastic localization.
authors.affiliation: Department of Surgical Gynecological Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Oriana
authors.forename: S
authors.initials: S
authors.lastname: Böhm
authors.forename: A
authors.initials: A
authors.lastname: Baeli
authors.forename: G
authors.initials: G
authors.lastname: Scavone
authors.forename: G
authors.initials: G
authors.lastname: Riboldi
authors.forename: A
authors.initials: A
authors.lastname: Torri
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000032:analysis / Q000401:mortality / Q000601:surgery*; D003600:Cytosol / Q000032:analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010052:Ovariectomy; D011960:Receptors, Estrogen / Q000032:analysis*; D012074:Remission Induction
chemical_list: D011960:Receptors, Estrogen