Alcoholism: scientific basis of a neuropsychogenetic disease.
Until recently alcoholism was regarded as being an incurable psychological problem. During the last decade a chain of research has led to a new insight into the causes and potential alleviation of alcohol craving: Recent discoveries indicate that the brain has receptor sites for naturally occurring opiate-like substances (endorphins and enkephalins) which are produced by the nervous system. Opiates such as morphine or heroin, and some of the metabolic products of alcohol (tetrahydroisoquinolines), can also attach themselves to these receptors. It has been further discovered that the craving for alcohol is related to a deficiency of the naturally occurring opiate-like substances as well as other neurotransmitter substances. This deficiency can occur genetically or as a result of prolonged stress or long-term heavy drinking. The neurochemical imbalance may be treated chemically, leading to a possible alleviation of the craving for alcohol, especially in conjunction with psychotherapeutic and counseling regimens.
Blum
K
K
Department of Pharmacology, University of Texas Health Sciences Center, San Antonio 78284.
Trachtenberg
M C
MC
D000437:Alcoholism / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D011957:Receptors, Opioid / Q000502:physiology; D019966:Substance-Related Disorders / Q000503:physiopathology*
D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter; D011957:Receptors, Opioid