[The protective effect of pantothenic acid derivatives and changes in the system of acetyl CoA metabolism in acute ethanol poisoning].
Calcium pantothenate (CaP), calcium 4'-phosphopantothenate (CaPP), pantethine, panthenol, sulfopantetheine and CoA decrease acute toxicity of acetaldehyde in mice. All studied compounds diminish duration of the narcotic action of ethanol--ET (3.5 g/kg intraperitoneally) in mice and rats. In the latter this effect is realized at the expense of "long sleeping" and "middle sleeping" animals. CaP (150 mg/kg subcutaneously) and CaPP (100 mg/kg subcutaneously) prevent hypothermia and a decrease of oxygen consumption in rats induced by ET administration. Combined administration of ET, CaP and CaPP leads to a characteristic increase of acid-soluble CoA fractions in the rat liver and a relative decrease of acetyl CoA synthetase and N-acetyltransferase reactions. The antitoxic effect of preparations of pantothenic acid is not mediated by CoA-dependent reactions of detoxication, but most probably is due to intensification of ET oxidation and perhaps to its elimination from the organism.
Moiseenok
A G
AG
Dorofeev
B F
BF
Omel'ianchik
S N
SN
D000079:Acetaldehyde / Q000506:poisoning; D000106:Acetate-CoA Ligase / Q000378:metabolism; D000105:Acetyl Coenzyme A / Q000096:biosynthesis*; D000107:Acetylation; D000435:Alcoholic Intoxication / Q000188:drug therapy* / Q000201:enzymology; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats
D010205:Pantothenic Acid; D000105:Acetyl Coenzyme A; D001191:Arylamine N-Acetyltransferase; D000106:Acetate-CoA Ligase; D000079:Acetaldehyde
Zashchitnyĭ éffekt proizvodnykh pantotenovoĭ kisloty i izmeneniia sistemy metabolizma atsetil-KoA pri ostroĭ intoksikatsii étanolom.