[Protective action of fat- and water-soluble antioxidants on the cytochrome P-450 system during lipid peroxidation in liver microsomes].
The protective effects of alpha-tocopherol, carnosine and their mixture on monooxygenase system during lipid peroxidation in liver microsome membranes were studied. It was shown that for optimal protection effect of cytochrome P-450 system the mixture of water and liposoluble antioxidants is required.
Serbinova
E A
EA
Kadiĭska
M B
MB
Tiurin
V A
VA
Kagan
V E
VE
Stoĭchev
Ts S
TsS
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002336:Carnosine / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010105:Oxygenases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D014810:Vitamin E; D002336:Carnosine; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases
Zashchitnoe deĭstvie lipo- i vodorastvorimykh antioksidantov na sistemu tsitokhroma P-450 pri perekisnom okislenii lipidov v mikrosomakh pecheni.