Diurnal changes in succinate and D-3-hydroxybutyrate dehydrogenase activities of rat liver mitochondria after chronic alcohol consumption and withdrawal.
1. The succinate dehydrogenase (SDH) and D-3-hydroxybutyrate dehydrogenase (HBDH) activities were measured over a 24-hr period in rat liver mitochondria after chronic alcohol ingestion and withdrawal. 2. The diurnal patterns of both the enzyme activities were shown to change after alcohol consumption, with 64-66% decrease in the daily mean levels. 3. The diurnal rhythms of the SDH and HBDH activities are partially restored 24-72 hr after alcohol withdrawal. 4. There was no correlation between changes in both the enzyme activities and the NAD+/NADH ratio of liver mitochondria from control, ethanol-fed and withdrawn rats over the day.
Kaminsky
Y G
YG
Institute of Biological Physics, USSR Academy of Sciences, Pushchino, Moscow Region.
Kosenko
E A
EA
D000437:Alcoholism / Q000201:enzymology*; D000818:Animals; D002940:Circadian Rhythm; D000431:Ethanol / Q000009:adverse effects*; D006884:Hydroxybutyrate Dehydrogenase / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D009243:NAD / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000201:enzymology*; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D009243:NAD; D000431:Ethanol; D006884:Hydroxybutyrate Dehydrogenase; D013385:Succinate Dehydrogenase