Adipsin mRNA amounts are not decreased in the genetically obese Zucker rat.
Adipsin gene expression as assessed by mRNA amounts was examined in adipose tissue of genetically obese rats at the onset (16 days of age) or at later stages (30 and 60 days of age) of obesity. Amounts of mRNA were equivalent in obese and lean rats at 16 days of age. In adult rats, we observed a 2-fold decrease in adipsin mRNA in the obese rats compared with control lean rats, which was abolished by weaning the animals on a high-fat diet. Our data show that, in sharp contrast with genetically obese mice, adipsin mRNA is not suppressed in genetically obese Zucker rats.
Dugail
I
I
INSERM U.177, Paris, France.
Le Liepvre
X
X
Quignard-Boulangé
A
A
Pairault
J
J
Lavau
M
M
D000273:Adipose Tissue / Q000032:analysis; D000818:Animals; D011416:Complement Factor D; D004032:Diet; D005260:Female; D005786:Gene Expression Regulation; D008297:Male; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics*; D051381:Rats; D011922:Rats, Mutant Strains / Q000235:genetics*; D011924:Rats, Zucker / Q000235:genetics*; D012697:Serine Endopeptidases / Q000235:genetics*
D012333:RNA, Messenger; D012697:Serine Endopeptidases; D011416:Complement Factor D