title: Anaphylactic symptoms due to chlorhexidine gluconate.
abstract: Six patients who developed urticaria, dyspnea, and anaphylactic shock due to topical application of chlorhexidine gluconate solution are described. Chlorhexidine gluconate was confirmed as the causative agent of type I hypersensitivity by intradermal, scratch, and epicutaneous tests. To prevent life-threatening adverse reactions, it seems important to use chlorhexidine gluconate on wound surfaces at a concentration of 0.05%, as recommended by the manufacturer; chlorhexidine gluconate may not be suitable for application to mucous membranes.
authors.affiliation: Department of Dermatology, Osaka University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Okano
authors.forename: M
authors.initials: M
authors.lastname: Nomura
authors.forename: S
authors.initials: S
authors.lastname: Hata
authors.forename: N
authors.initials: N
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Kitano
authors.forename: M
authors.initials: M
authors.lastname: Tashiro
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshimoto
authors.forename: R
authors.initials: R
authors.lastname: Hama
authors.forename: T
authors.initials: T
authors.lastname: Aoki
mesh_terms: D000293:Adolescent; D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced*; D002648:Child; D002710:Chlorhexidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000276:immunology; D004342:Drug Hypersensitivity / Q000209:etiology*; D004417:Dyspnea / Q000139:chemically induced; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D014581:Urticaria / Q000139:chemically induced
chemical_list: C010882:chlorhexidine gluconate; D002710:Chlorhexidine