A comparative study of copper ion induced lysis of vertebrate red blood cells.
1. Erythrocytes from different vertebrate classes were tested for susceptibility towards copper ion-induced lysis under identical copper ion concentration and per cent cell volumes. 2. The susceptibility towards lysis was found to be correlated with the rate of copper ion entry into the erythrocytes. 3. GSH levels decline in red blood cells at a rate proportional to the rate of copper ion entry. 4. Hemolysis does not seem to be causally related to the level of GSH in the erythrocytes.
Smith
H A
HA
Department of Chemistry, Florida State University, Tallahassee 32306-3006.
Dasmahapatra
A K
AK
Caffrey
J M
JM
Frieden
E
E
D000818:Animals; D003300:Copper / Q000633:toxicity*; D005978:Glutathione / Q000032:analysis; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D013045:Species Specificity; D014714:Vertebrates
D003300:Copper; D005978:Glutathione