title: Dedifferentiated parosteal osteosarcoma of the femur with aneuploidy and lung metastases.
abstract: In this report, the pathologic findings and the results of cellular DNA measurements of a tumor that on first presentation seemed to be a classical parosteal osteosarcoma are described. After resection 8 months later, part of the tumor appeared to display highly malignant features. DNA flow cytometry of this part of the tumor showed an aneuploid cell population. The aggressive nature of the tumor was confirmed by the development of lung metastases approximately 1 year after resection of the primary tumor.
authors.affiliation: Department of Pathology, University Hospital of Groningen, The Netherlands.
authors.forename: M W
authors.initials: MW
authors.lastname: van Oven
authors.forename: W M
authors.initials: WM
authors.lastname: Molenaar
authors.forename: N J
authors.initials: NJ
authors.lastname: Freling
authors.forename: H
authors.initials: H
authors.lastname: Schraffordt Koops
authors.forename: N
authors.initials: N
authors.lastname: Muis
authors.forename: A
authors.initials: A
authors.lastname: Dam-Meiring
authors.forename: J W
authors.initials: JW
authors.lastname: Oosterhuis
mesh_terms: D000328:Adult; D000782:Aneuploidy; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005266:Femoral Neoplasms / Q000473:pathology*; D005434:Flow Cytometry; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D012516:Osteosarcoma / Q000032:analysis / Q000473:pathology* / Q000556:secondary
chemical_list: D004273:DNA, Neoplasm