title: [Synthesis and antiparasitic activity of arylproprenones in the nitro-5-imidazole series].
abstract: The synthesis of new arylpropenones derived from 1-methyl-5-nitro imidazole is described. The investigation of some antiprotozoal properties has shown that compounds with the groups 4-hydroxyphenyl, 4-chlorophenyl or thiophenyl have trichomonacidal activity similar to that of metronidazole.
authors.affiliation: Laboratoire de Chimie Thérapeutique et Chimique Organique, Faculté de Pharmacie D'Abidjan, Côte D'Ivoire.
authors.forename: L
authors.initials: L
authors.lastname: Ouattara
authors.forename: M
authors.initials: M
authors.lastname: Debaert
authors.forename: R
authors.initials: R
authors.lastname: Cavier
mesh_terms: D000563:Amebicides / Q000138:chemical synthesis*; D000818:Animals; D000994:Antitrichomonal Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004748:Entamoeba histolytica / Q000187:drug effects; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014246:Trichomonas vaginalis / Q000187:drug effects
chemical_list: D000563:Amebicides; D000994:Antitrichomonal Agents; D009593:Nitroimidazoles
vernacular_title: Synthese et activite antiparasitaire d'aryl-propenones en serie nitro-5 imidazolique.