Synthesis and antibacterial activity of novel 3-substituted carbacephems.
A series of novel 3-heterocyclothio substituted carbacephems having phenylglycyl side chain have been prepared starting from 3-H carbacephem. The compounds exhibit better chemical stability than the corresponding cephalosporin and strong activity against Gram-negative and Gram-positive organisms including Enterococcus faecalis.
Mochida
K
K
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
Ogasa
T
T
Shimada
J
J
Hirata
T
T
Sato
K
K
Okachi
R
R
D002511:Cephalosporins / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D004355:Drug Stability; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D002511:Cephalosporins; C026739:carbacephems