title: Molecular cloning of the human transmembrane secretory component (poly-Ig receptor) and its mRNA expression in human tissues.
abstract: A 2.5 kilobase (kb) cDNA clone containing 92% of the coding region for human transmembrane secretory component (SC) or poly-Ig receptor, was isolated from a mammary gland cDNA library. The cDNA clone encoded a protein of 693 amino acids which showed 99% homology with the primary amino acid sequence of human free SC as reported by Eiffert et al. (1), and 54% homology with the deduced amino acid sequence of rabbit transmembrane SC for which cDNA was cloned by Mostov et al. (2). Northern blot analysis showed mRNA expression in various human exocrine tissues in good agreement with our previous immunohistochemical studies of SC.
authors.affiliation: Laboratory for Immunohistochemistry and Immunopathology, and University of Oslo, Rikshospitalet, Norway.
authors.forename: P
authors.initials: P
authors.lastname: Krajci
authors.forename: R
authors.initials: R
authors.lastname: Solberg
authors.forename: M
authors.initials: M
authors.lastname: Sandberg
authors.forename: O
authors.initials: O
authors.lastname: Oyen
authors.forename: T
authors.initials: T
authors.lastname: Jahnsen
authors.forename: P
authors.initials: P
authors.lastname: Brandtzaeg
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001940:Breast / Q000032:analysis; D002462:Cell Membrane / Q000032:analysis*; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007128:Immunoglobulin Fragments / Q000235:genetics*; D007774:Lactation; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D011247:Pregnancy; D011817:Rabbits; D012635:Secretory Component / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D007128:Immunoglobulin Fragments; D012635:Secretory Component; D004247:DNA