Co-ordinate control of CDP-choline and phosphatidylethanolamine methyltransferase pathways for phosphatidylcholine biosynthesis occurs in response to change in diet fat.
Brain microsomal and synaptic plasma membrane phosphatidylcholine composition and biosynthetic activity were examined in relation to the composition of diet fat fed. Phosphocholinetransferase and methyltransferase activities are shown to be modulated by the diet, and by changes in the membrane phospholipid content of long-chain polyunsaturated fatty acids. This physiological modulation is co-ordinated such that the rate of phosphatidylcholine synthesis via one route is inversely regulated with activity of the alternate pathway.
Hargreaves
K M
KM
Department of Foods and Nutrition, Faculty of Home Economics, University of Alberta, Edmonton, Canada.
Clandinin
M T
MT
D000818:Animals; D001921:Brain / Q000166:cytology; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000378:metabolism*; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000494:pharmacology; D008297:Male; D008563:Membrane Lipids / Q000032:analysis*; D008780:Methyltransferases / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000096:biosynthesis*; D050918:Phosphatidylethanolamine N-Methyltransferase; D051381:Rats; D011919:Rats, Inbred Strains; D013570:Synaptic Membranes / Q000032:analysis / Q000187:drug effects
D004041:Dietary Fats; D005227:Fatty Acids; D008563:Membrane Lipids; D010713:Phosphatidylcholines; D003566:Cytidine Diphosphate Choline; D008780:Methyltransferases; D050918:Phosphatidylethanolamine N-Methyltransferase; D002794:Choline