title: Management of clinically suspected acute venous thrombosis in outpatients with serial impedance plethysmography in a community hospital setting.
abstract: The reported high sensitivity and specificity of impedance plethysmography (IPG) in the diagnosis of proximal vein thrombosis were evaluated in a prospective cohort follow-up study, in which IPG was performed three times over a period of seven days in 243 consecutive outpatients with clinically suspected deep venous thrombosis (DVT). The test was abnormal in 112 patients (46%). The positive predictive value of an abnormal IPG for venography-proved DVT was 90%. One hundred thirty-one patients (54%) with repeatedly normal tests were considered not to have DVT, and anticoagulants were withheld. During six months of follow-up, completed in all patients with repeatedly normal IPG, no patient died of venous thromboembolism and no patient returned with clinically suspected pulmonary embolism. One patient (0.8%) returned after two months with recurrent leg symptoms, and venous thrombosis was documented (95% confidence limits, 0.02% to 4.21%). Another patient, who was nonsymptomatic, had an abnormal IPG at the three-month follow-up visit, and venography revealed venous thrombosis. Patients sent by general practitioners to a community hospital, with clinically suspected acute DVT, can be effectively managed by serial IPG alone.
authors.affiliation: Centre for Thrombosis, Haemostasis, and Atherosclerosis Research, Amsterdam, the Netherlands.
authors.forename: M V
authors.initials: MV
authors.lastname: Huisman
authors.forename: H R
authors.initials: HR
authors.lastname: Büller
authors.forename: J W
authors.initials: JW
authors.lastname: ten Cate
authors.forename: H S
authors.initials: HS
authors.lastname: Heijermans
authors.forename: J
authors.initials: J
authors.lastname: van der Laan
authors.forename: D J
authors.initials: DJ
authors.lastname: van Maanen
mesh_terms: D000553:Ambulatory Care; D000925:Anticoagulants / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006764:Hospitals, Community; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D010044:Outpatient Clinics, Hospital; D010992:Plethysmography, Impedance; D011446:Prospective Studies; D013924:Thrombophlebitis / Q000175:diagnosis* / Q000628:therapy; D013997:Time Factors
chemical_list: D000925:Anticoagulants