title: Enhancement of hepatic tumors induced by N-nitrosodimethylamine in female toads Bufo regularis by oestrone.
abstract: The effect of oestrone on hepatic tumours induced in the female toads Bufo regularis by N-nitrosodimethylamine (DMNA) was evaluated. Injecting the toads with DMNA induced hepatocellular carcinomas in 17% comparable with 23% in toads injected with DMNA plus oestrone. These results show that oestrone insignificantly enhanced the tumour formation. Oestrone alone induced hepatic tumours in only 4 cases and was considered as a weak initiator.
authors.affiliation: Department of Zoology, Faculty of Science, Menoufia University, Egypt.
authors.forename: S A
authors.initials: SA
authors.lastname: Sakr
authors.forename: M M
authors.initials: MM
authors.lastname: el-Mofty
authors.forename: A M
authors.initials: AM
authors.lastname: Mohamed
mesh_terms: D000818:Animals; D002025:Bufonidae; D002273:Carcinogens; D004128:Dimethylnitrosamine; D004357:Drug Synergism; D004970:Estrone; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*
chemical_list: D002273:Carcinogens; D004970:Estrone; D004128:Dimethylnitrosamine