title: Ketoconazole: a possible direct cytotoxic effect on prostate carcinoma cells.
abstract: Ketoconazole has been recently used in the treatment of advanced prostatic cancer and is believed to exert its effect by inhibition of androgen production. In order to determine whether ketoconazole exerts an additional direct cytotoxic effect on prostate cancer cells, we studied its effect on human hormone-independent prostate cancer cell lines (PC-3 and DU-145) in an in vitro clonogenic tumor assay. We showed that clinically achievable doses of ketoconazole caused greater than 90% suppression of tumor colony growth.
authors.affiliation: Division of Urology, Toronto General Hospital, Ontario, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Eichenberger
authors.forename: J
authors.initials: J
authors.lastname: Trachtenberg
authors.forename: P
authors.initials: P
authors.lastname: Toor
authors.forename: A
authors.initials: A
authors.lastname: Keating
mesh_terms: D002277:Carcinoma; D002460:Cell Line; D003114:Colony-Forming Units Assay; D006801:Humans; D007654:Ketoconazole / Q000494:pharmacology*; D008297:Male; D011471:Prostatic Neoplasms; D014410:Tumor Stem Cell Assay
chemical_list: D007654:Ketoconazole