Umbilical artery creatine kinase brain-band isozyme as a predictor of neonatal periventricular-intraventricular hemorrhage.
In low-birth-weight neonates, an elevation in the percentage of creatine kinase brain-band isozyme in the umbilical artery was significantly correlated with future development of neonatal grade III and grade IV periventricular-intraventricular hemorrhage, when compared with levels in those neonates who did not show periventricular-intraventricular hemorrhage or who developed grade I and grade II periventricular-intraventricular hemorrhage (p = 0.025). In these neonates the relative levels in maternal venous, umbilical arterial, and umbilical venous samples indicated that the source of the isozyme was fetal.
Bardeguez
A
A
Department of Obstetrics and Gynecology, Nassau County Medical Center, East Meadow, NY.
Tejani
N
N
Verma
U L
UL
Kim
S J
SJ
D001034:Apgar Score; D001724:Birth Weight; D001784:Blood Gas Analysis; D002543:Cerebral Hemorrhage / Q000175:diagnosis*; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000201:enzymology*; D005865:Gestational Age; D006340:Heart Rate, Fetal; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007527:Isoenzymes; D011237:Predictive Value of Tests; D011247:Pregnancy
D007527:Isoenzymes; D003402:Creatine Kinase