title: Red blood cell fatty acids in multiple sclerosis.
abstract: The fatty acid (FA) composition of each phospholipid constituent of the red blood cells (RBC) was analyzed, by thin-layer and gas chromatography techniques, in 61 multiple sclerosis (MS) patients and 61 normal subjects, in whom the plasma lipid FA composition had previously been studied. The MS patients showed a significant decrease in the proportions of linoleic and arachidonic acids in most phospholipids, with a compensatory increase of saturated FA. Correlations between FA percentages in plasma and cell lipids demonstrated abnormalities in the MS patients, suggestive of a disturbance in the exchange between these compartments. The alterations reported in plasma and RBC in the MS patients are consistent with a relative deficiency of essential FA.
authors.affiliation: Department of Physiology, Autonomous University of Barcelona, Spain.
authors.forename: X
authors.initials: X
authors.lastname: Navarro
authors.forename: R
authors.initials: R
authors.lastname: Segura
mesh_terms: D001095:Arachidonic Acids / Q000097:blood; D004912:Erythrocytes / Q000032:analysis*; D005227:Fatty Acids / Q000097:blood*; D006801:Humans; D008041:Linoleic Acids / Q000097:blood; D009103:Multiple Sclerosis / Q000097:blood*; D010743:Phospholipids / Q000097:blood; D010949:Plasma / Q000032:analysis
chemical_list: D001095:Arachidonic Acids; D005227:Fatty Acids; D008041:Linoleic Acids; D010743:Phospholipids