Unconventional pathogens causing spongiform encephalopathies absent in blood products.
To determine whether unconventional pathogens causing subacute spongiform encephalopathy may be present in blood products, a newly developed hepatitis B vaccine and a widely used blood product were injected into mice and rats. As only a few aged mice in the test and the control groups showed spongiform encephalopathic change of a sparse or mild degree and which differed from that seen in rodents infected with Creutzfeldt-Jakob disease, the presence of unconventional pathogens in the tested inocula can be ruled out.
Tateishi
J
J
Tsuji
S
S
D000818:Animals; D001798:Blood Proteins; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000382:microbiology* / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000209:etiology; D004340:Drug Contamination; D005260:Female; D006509:Hepatitis B / Q000097:blood*; D017325:Hepatitis B Vaccines; D008099:Liver / Q000473:pathology; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D012712:Serum Globulins; D012897:Slow Virus Diseases / Q000382:microbiology*; D014761:Viral Hepatitis Vaccines
D001798:Blood Proteins; D017325:Hepatitis B Vaccines; D012709:Serum Albumin; D012712:Serum Globulins; D014761:Viral Hepatitis Vaccines; C008930:plasma protein fraction; D000075462:Serum Albumin, Human