Monoamine and metabolite levels in the prefrontal cortex and the mesolimbic forebrain following neonatal lesions of the ventral tegmental area.
Monoamine metabolism was determined in the medial prefrontal cortex (mPFC) and the limbic forebrain (LFB) of adult rats following neonatal lesions of the ventral tegmental area. The dopamine (DA) and serotonin (5-HT) levels were decreased down to 30% in both the mPFC and the LFB. The noradrenaline (NA) level was also significantly decreased, but only in the mPFC of the right hemisphere. The metabolite/transmitter ratios of DA and 5-HT, but not of NA, were greatly increased in the depleted mPFC, but not in the LFB, which suggests an increased activity of the remaining cortical DA and 5-HT fibres in the mPFC.
Kalsbeek
A
A
Netherlands Institute for Brain Research, Amsterdam.
Feenstra
M G
MG
van Galen
H
H
Uylings
H B
HB
D000818:Animals; D000831:Animals, Newborn; D015306:Biogenic Monoamines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D005625:Frontal Lobe / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013681:Tegmentum Mesencephali / Q000502:physiology*
D015306:Biogenic Monoamines; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine