Minocycline-associated tooth discoloration in young adults.
After observing a patient with adult-onset tooth discoloration coincident with minocycline administration, we retrospectively surveyed a cohort of patients with severe cystic acne during therapeutic trials with isotretinoin. Four of 72 patients who had minocycline therapy during adolescence were found to have minocycline-associated tooth discoloration, which occurred in one case after only four weeks of treatment. Thus, minocycline must be considered as an uncommon cause of tooth staining in adults.
Poliak
S C
SC
DiGiovanna
J J
JJ
Gross
E G
EG
Gantt
G
G
Peck
G L
GL
D000152:Acne Vulgaris / Q000188:drug therapy / Q000473:pathology; D000293:Adolescent; D000328:Adult; D006801:Humans; D008297:Male; D008911:Minocycline / Q000009:adverse effects*; D012189:Retrospective Studies; D012880:Skin Pigmentation / Q000187:drug effects; D013754:Tetracyclines / Q000009:adverse effects*; D014075:Tooth Discoloration / Q000139:chemically induced*
D013754:Tetracyclines; D008911:Minocycline