The carotid bodies of spontaneously hypertensive rats (SHR) after long-term stimulation by almitrine bismesylate.
The influence of daily oral application of 1.0 mg/kg almitrine bismesylate given from the 17th to the 30th week of age on the carotid bodies of male spontaneously hypertensive rats (SHR) was studied. Neither an enlargement nor histological changes of the carotid bodies were found. The results are compared with findings obtained after exposure of SHR to long-term hypobaric hypoxia and discussed.
Habeck
J O
JO
Institute of Pathology, Bezirkskrankenhaus, Friedrich Wolf, GDR.
Huckstorf
C
C
Mewes
H
H
D015765:Almitrine; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002344:Carotid Body / Q000033:anatomy & histology* / Q000166:cytology / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D012016:Reference Values
D000697:Central Nervous System Stimulants; D010879:Piperazines; D015765:Almitrine