Plasma binding of 1-butanol, phenol, nitrobenzene and pentachlorophenol in the rainbow trout and rat: a comparative study.
1. The in vitro binding of 1-butanol, phenol, nitrobenzene, and pentachlorophenol in trout plasma and rat plasma was determined. 2. Binding to rainbow trout plasma proteins agreed within 9% of that observed in rat plasma. 3. Percentage bound to rainbow trout (2-99%) or rat (10-99%) plasma proteins increased as the log octanol/water partition coefficient of the chemicals increased within the Log P 1-3 range, and was suggestive of hydrophobic interactions in binding.
Schmieder
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U.S. Environmental Protection Agency, Environmental Research Laboratory-Duluth, MN 55804.
Henry
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TR
D020001:1-Butanol; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D000440:Butanols / Q000097:blood*; D002733:Chlorophenols / Q000097:blood*; D009578:Nitrobenzenes / Q000097:blood*; D010416:Pentachlorophenol / Q000097:blood*; D019800:Phenol; D010636:Phenols / Q000097:blood*; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains; D012487:Salmonidae / Q000097:blood*; D014337:Trout / Q000097:blood*
D001798:Blood Proteins; D000440:Butanols; D002733:Chlorophenols; D009578:Nitrobenzenes; D010636:Phenols; D019800:Phenol; D020001:1-Butanol; D010416:Pentachlorophenol; C036077:nitrobenzene