title: Purpura fulminans. A case for heparin therapy.
abstract: A 6.5-year-old boy developed purpura fulminans. He had no evidence of congenital protein C deficiency. He responded readily to heparin therapy with resolution of his coagulopathy. The coagulopathy resumed rapidly after heparin therapy was interrupted to allow for surgical procedures. Despite correction of his coagulopathy with heparin, surgical amputation of his leg was necessary because of inadequate perfusion.
authors.affiliation: Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38101-0318.
authors.forename: P J
authors.initials: PJ
authors.lastname: Chenaille
authors.forename: M E
authors.initials: ME
authors.lastname: Horowitz
mesh_terms: D000671:Amputation, Surgical; D002648:Child; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy / Q000503:physiopathology; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007866:Leg / Q000098:blood supply / Q000601:surgery; D008297:Male; D011693:Purpura / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D006493:Heparin