title: Multicentric reticulohistiocytosis in a child with sclerosing lesion of the leg. Immunohistopathologic studies and therapeutic trial with systemic cyclosporine.
abstract: Multicentric reticulohistiocytosis affecting a 13-year-old boy induced a sclerosing change of the leg. The cellular infiltrate comprising activated T lymphocytes and macrophages and human lymphocyte antigen (HLA)-DR expression by keratinocytes in lesional skin all suggest the involvement of cellular immune reactions. We administered systemic cyclosporine but could not obtain a favorable effect without a concomitant low dosage of prednisone.
authors.affiliation: Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kuramoto
authors.forename: O
authors.initials: O
authors.lastname: Iizawa
authors.forename: S
authors.initials: S
authors.lastname: Aiba
authors.forename: Y
authors.initials: Y
authors.lastname: Makino
authors.forename: H
authors.initials: H
authors.lastname: Tagami
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal; D001706:Biopsy; D003524:Cyclosporins / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D007871:Leg Ulcer / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008206:Lymphatic Diseases / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal; D003524:Cyclosporins; D006684:HLA-DR Antigens; D011241:Prednisone