Indomethacin and bone remodeling. Effect on cortical bone after osteotomy in rabbits.
Remodeling in cortical bone close to a plated tibial midshaft osteotomy was histomorphometrically evaluated in 32 rabbits. The animals were divided into two groups, one being treated with indomethacin (10 mg/kg per day) and the other receiving placebo. In the placebo-treated group, the remodeling activity was higher in the osteotomized leg compared with the intact leg. Two and 6 weeks after osteotomy, the number of resorptive and formative foci was reduced in the indomethacin-treated group compared with the placebo group. Porosity did not differ between the groups after 2 weeks; but after 6 weeks, it was reduced in the indomethacin-treated animals. Throughout the study, the bone formation rate did not differ between the two groups. This study demonstrates that indomethacin inhibits the remodeling of traumatized bone.
Keller
J
J
University of Arhus, Institute of Experimental Clinical Research, Denmark.
Bayer-Kristensen
I
I
Bak
B
B
Bünger
C
C
Kjaersgaard-Andersen
P
P
Lucht
U
U
Melsen
F
F
D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D001860:Bone Plates; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology; D007213:Indomethacin / Q000494:pharmacology*; D010027:Osteotomy; D011817:Rabbits; D013977:Tibia / Q000601:surgery
D007213:Indomethacin