title: 5-(1-piperazinyl)-1H-1,2,4-triazol-3-amines as antihypertensive agents.
abstract: A series of 5-(1-piperazinyl)-1H-1,2,4-triazol-3-amines was synthesized and screened for antihypertensive and diuretic activity in spontaneously hypertensive rats (SHR). One compound, 5-[4-[(3-chlorophenyl)methyl]-1-piperazinyl]-1H-1,2,4-triazol-3-am ine (8), was selected to define the mechanism of its antihypertensive activity. Studies in SHR suggest ganglionic blocking activity. Short-lived antihypertensive activity was observed in conscious renal hypertensive dogs.
authors.affiliation: American Cyanamid Company, Medical Research Division, Lederle Laboratories, Pearl River, New York 10965.
authors.forename: W E
authors.initials: WE
authors.lastname: Meyer
authors.forename: A S
authors.initials: AS
authors.lastname: Tomcufcik
authors.forename: P S
authors.initials: PS
authors.lastname: Chan
authors.forename: M
authors.initials: M
authors.lastname: Haug
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004232:Diuretics / Q000138:chemical synthesis; D004285:Dogs; D006973:Hypertension / Q000503:physiopathology; D006978:Hypertension, Renovascular / Q000503:physiopathology; D008297:Male; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D010879:Piperazines; D014230:Triazoles