Opti-Free chemical disinfectant: a safety study with various soft contact lenses.
A 6-month, Phase I clinical study evaluated Opti-Free, a new polyquaternium-1 chemical disinfectant intended for use with all types of soft contact lenses. Fifty-one patients were enrolled and divided into two groups. Group A used the product under exaggerated conditions, with daily exposure of Durasoft 3 (55%) and Hydrocurve II (55%) medium water content, ionic lenses to 5 mL of Opti-Free for 16 hours. Beginning on day 15, group A patients began a normal daily use schedule. Patients in group B wore CSI (38%), Permalens (71%), and Softcon (55%) contact lenses and used the regimen under normal daily use conditions throughout the study. The result indicate that Opti-Free is safe and effective under both normal and exaggerated use conditions. The implications of these data for patient safety are discussed.
Gibbs
D E
DE
Alcon Laboratories, Inc., Forth Worth, TX 76134-2099.
Stein
J M
JM
Rockett
J
J
Nicovich-Cushing
G
G
Anderson
M
M
Carmichael
C
C
D003263:Contact Lenses, Hydrophilic; D004202:Disinfectants / Q000009:adverse effects; D005123:Eye / Q000473:pathology; D005128:Eye Diseases / Q000139:chemically induced; D006801:Humans; D010865:Pilot Projects; D011108:Polymers; D013997:Time Factors; D014792:Visual Acuity
D004202:Disinfectants; D011108:Polymers; C058655:polyquaternium 1