Presence of androgen receptors in the hen hypothalamus and pituitary.
Soluble and insoluble fractions in a hypotonic buffer solution of hypothalamic-preoptic and median eminence areas, and of the anterior pituitary of the hen were found to contain a specific androgen binding component having the properties of a receptor. Administration of testosterone in vivo caused a marked decrease in specific [3H]R1881 (a synthetic androgen) bindings in the soluble fraction with a concomitant increase in the bindings in the insoluble fraction, whereas the sum of the bindings did not change. A similar relationship between the bindings of the two fractions was also observed during an ovulatory cycle. The results may provide an evidence for a direct action of androgens on the hen hypothalamus and pituitary.
Kawashima
M
M
Department of Poultry and Animals Sciences, Gift University, Japan.
Kamiyoshi
M
M
Tanaka
K
K
D000818:Animals; D005260:Female; D007031:Hypothalamus / Q000378:metabolism*; D008473:Median Eminence / Q000378:metabolism; D010060:Ovulation / Q000187:drug effects; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011200:Poultry / Q000378:metabolism*; D011301:Preoptic Area / Q000378:metabolism; D011506:Proteins / Q000032:analysis; D011944:Receptors, Androgen / Q000378:metabolism*; D013739:Testosterone / Q000008:administration & dosage
D011506:Proteins; D011944:Receptors, Androgen; D013739:Testosterone