title: Leukemia cell specific protein of the bivalve mollusc Mya arenaria.
abstract: Soft shell clams, Mya arenaria, develop leukemias in the hemolymph which are fatal. Tissue sections and hemolymph samples from normal and tumor-bearing clams were tested with an anti-leukemic cell specific monoclonal antibody (Mab) "IEII." Evaluation of leukemic cells and normal hemocytes by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot analyses showed that Mab IEII bound to a large protein of approximately 200 kDa from the tumor cell, but not from the normal cell preparation.
authors.forename: D L
authors.initials: DL
authors.lastname: Miosky
authors.forename: R M
authors.initials: RM
authors.lastname: Smolowitz
authors.forename: C L
authors.initials: CL
authors.lastname: Reinisch
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D049872:Bivalvia / Q000032:analysis*; D007938:Leukemia / Q000276:immunology*; D009363:Neoplasm Proteins / Q000032:analysis* / Q000276:immunology; D014407:Tumor Cells, Cultured
chemical_list: D000911:Antibodies, Monoclonal; D009363:Neoplasm Proteins