title: The pharmacokinetics of ciprofloxacin in patients with impaired renal function.
abstract: Pharmacokinetics of ciprofloxacin after single oral administration of 250 mg were studied in patients with and without renal failure. Ciprofloxacin concentrations were measured by HPLC. The elimination half-life was 8.7 +/- 0.9 h (mean +/- S.E.M.) in six renal failure patients not on haemodialysis, as compared to 4.4 +/- 0.2 h in six patients with normal renal function. The urinary recovery of unchanged ciprofloxacin was 5.3 +/- 1.7% of dose over 24 h in the renal failure patients, as compared to 37.0 +/- 3.7% in the patients with normal renal function. In haemodialysis patients, the half-life was 5.8 +/- 0.9 h on an interdialysis day, and 3.2 +/- 0.4 h during haemodialysis.
authors.forename: J
authors.initials: J
authors.lastname: Boelaert
authors.forename: Y
authors.initials: Y
authors.lastname: Valcke
authors.forename: M
authors.initials: M
authors.lastname: Schurgers
authors.forename: R
authors.initials: R
authors.lastname: Daneels
authors.forename: M
authors.initials: M
authors.lastname: Rosseneu
authors.forename: M T
authors.initials: MT
authors.lastname: Rosseel
authors.forename: M G
authors.initials: MG
authors.lastname: Bogaert
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D002939:Ciprofloxacin; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011804:Quinolines / Q000008:administration & dosage / Q000378:metabolism*; D006435:Renal Dialysis
chemical_list: D011804:Quinolines; D002939:Ciprofloxacin