title: Psychotic patients who become worse on neuroleptics.
abstract: We describe a group of psychotic patients who became worse early in the course of neuroleptic treatment. Characteristics of this group were: predominantly female sex, relatively brief onset, family history of affective disorder, hypomotoric presentation, and severe neuroleptic side effects. We propose that some patients with affective psychoses are uniquely susceptible to profound blockade of the nigrostriatal dopaminergic system by neuroleptics.
authors.affiliation: Yale University School of Medicine, Department of Psychiatry, New Haven, Connecticut 06519.
authors.forename: M B
authors.initials: MB
authors.lastname: Bowers
authors.forename: M E
authors.initials: ME
authors.lastname: Swigar
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001590:Benztropine / Q000627:therapeutic use; D002746:Chlorpromazine / Q000009:adverse effects; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D005260:Female; D006220:Haloperidol / Q000009:adverse effects; D006801:Humans; D008297:Male; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D011618:Psychotic Disorders / Q000188:drug therapy*; D013888:Thiothixene / Q000009:adverse effects
chemical_list: D014150:Antipsychotic Agents; D001590:Benztropine; D013888:Thiothixene; D006220:Haloperidol; D002746:Chlorpromazine