title: Effect of age and growth rate on myocardial irritability in broiler chickens.
abstract: Young broiler chickens are undergoing a period of extremely rapid growth and may be expected to be in a state of extreme endocrine and biochemical flux. These birds are also subject to a sudden death syndrome of unknown etiology. We hypothesized that an increased myocardial sensitivity in birds exhibiting early rapid growth may contribute to this syndrome. The objective of the current study was to investigate the interaction between early growth rate and age on myocardial irritability in young broiler chickens. This study utilized 74 male broiler chickens between 3 (Group A, 21-24 days) and 6 (Group B, 43-47 days) weeks of age exhibiting rapid (heavy weight, greater than 425 g at 2 weeks) and slow (low weight, less than 350 g at 2 weeks) early growth. Physiologic parameters such as blood pressure, heart rate, and arterial blood gases in the awake, restrained birds were essentially unchanged across these groups. Myocardial irritability of the anesthetized bird (pentobarbital) as measured by the threshold to electrical fibrillation was significantly increased only in the Group A HW birds. The results of this study suggest an increased myocardial irritability in large young broilers (3 weeks of age) that is no longer present in a similar group of older birds (6 weeks of age). These findings are consistent with the hypothesis that there is an increased myocardial sensitivity in birds succumbing to sudden death syndrome, with death due to myocardial fibrillation. Further research is needed to determine the mechanisms involve.
authors.affiliation: Department of Veterinary Biosciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061.
authors.forename: K J
authors.initials: KJ
authors.lastname: Greenlees
authors.forename: P
authors.initials: P
authors.lastname: Eyre
authors.forename: J C
authors.initials: JC
authors.lastname: Lee
authors.forename: C T
authors.initials: CT
authors.lastname: Larsen
mesh_terms: D000375:Aging; D000818:Animals; D001794:Blood Pressure; D009202:Cardiomyopathies / Q000209:etiology / Q000503:physiopathology / Q000662:veterinary*; D002645:Chickens; D004558:Electric Stimulation; D006339:Heart Rate; D010100:Oxygen / Q000097:blood; D011201:Poultry Diseases / Q000209:etiology* / Q000503:physiopathology; D015430:Weight Gain
chemical_list: D010100:Oxygen