Depression of calcium current at mouse motor nerve endings by polycationic antibiotics.
The hypothesis according to which polycationic antibiotics produce neuromuscular block by interfering with the Ca current of motor nerve terminals has been examined using external electrodes in nerve-muscle preparations of the mouse. It was found that kanamycin, bekanamycin and polymyxin B depressed presynaptic Ca currents probably by neutralizing negative surface charges.
Bourret
C
C
Unité de Physiologie Neuromusculaire, C.N.R.S., Gif-sur-Yvette, France.
Mallart
A
A
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002118:Calcium / Q000502:physiology*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D007612:Kanamycin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D013757:Tetraethylammonium Compounds; C001495:bekanamycin; D007612:Kanamycin; D002118:Calcium