[The action of hypothalamic hormone on athymic mice with transplantable strains of human tumors].
The sensitivity of human melanoma and lung cancer strains transplanted to nude mice to the synthetic hormone of hypothalamus--melanostatin has been defined. Correlation has been noted between the rate of melanoma growth inhibition, decrease in the rate of Na-fluorescent accumulation in the tumor and the tendency towards depression of the activity of energetic metabolism enzymes (SDH and alpha-GPDH) in the treated tumors as compared to control. Moderate lymphopenia and absence of effect on the same enzymes of the lymphocytes was also observed. Fluorescent probes can be used in the estimation of the drug action on the tumor and organs.
Bukharova
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Osokina
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Revazova
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Smirnova
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D000818:Animals; D004353:Drug Evaluation, Preclinical; D019793:Fluorescein; D005452:Fluoresceins; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D009075:MSH Release-Inhibiting Hormone / Q000627:therapeutic use*; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D013385:Succinate Dehydrogenase / Q000378:metabolism
D005452:Fluoresceins; D009075:MSH Release-Inhibiting Hormone; D005993:Glycerolphosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D019793:Fluorescein
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