Increased 3H-thymidine incorporation into DNA of organ-cultured adrenal explants from rats injected with corticotropin and/or cysteamine.
The effect of a single injection of cysteamine /CySH/ - a sulfhydryl substance, known to deplete tissue content of somatostatin /SS/ - on 3H-thymidine incorporation into DNA of rat adrenal explants incubated in vitro was investigated. It was shown that: 1/ Single in vivo injection of ACTH or of CySH increased 3H-thymidine incorporation into DNA of the organ-cultured adrenals, 2/ Dexamethasone reduced the 3H-thymidine uptake, but that decrease did not attain statistical significance versus controls.
Sewerynek
E
E
Department of Experimental Endocrinology and Hormone Diagnostic, Medical Academy of Lódź, Poland.
Szkudliński
M
M
Lewiński
A
A
Kunert-Radek
J
J
D000311:Adrenal Glands / Q000166:cytology* / Q000187:drug effects; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003543:Cysteamine / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D003907:Dexamethasone / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D013004:Somatostatin / Q000037:antagonists & inhibitors
D013004:Somatostatin; D003543:Cysteamine; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D004247:DNA