Dinoseb toxicosis in two dogs.
Two male English Setters were noticed to be breathing rapidly, hyperexcitable, and atactic after roaming a rural area for 2 hours. Both dogs' cost were stained with yellow liquid. One dog died while en route to the veterinarian. Treatment was begun for the surviving dog for what was initially diagnosed to be organophosphorus or carbamate insecticide toxicosis. Before the diagnosis could be confirmed, the second dog died. The yellow liquid on the dogs' skin was identified as dinoseb in high concentrations. Dinoseb is an acutely toxic, substituted dinitrophenolic herbicide believed to act as an uncoupler of electron transport from oxidative phosphorylation.
Fikes
J D
JD
Illinois Animal Posion Information Center, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Lovell
R A
RA
Metzler
M
M
Buck
W B
WB
D019297:2,4-Dinitrophenol / Q000031:analogs & derivatives*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004140:Dinitrophenols / Q000506:poisoning*; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D004579:Electron Transport / Q000187:drug effects; D006540:Herbicides / Q000506:poisoning*; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D010085:Oxidative Phosphorylation / Q000187:drug effects
D004140:Dinitrophenols; D006540:Herbicides; D007306:Insecticides; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D019297:2,4-Dinitrophenol; C018527:dinoseb