Studies on correlations between chloroquine-induced tissue damage and serum enzyme changes in the rat.
The administration of chloroquine to rats resulted in a significant elevation of serum enzymes and a corresponding decrease of these enzymes in the tissues. The changes in serum and kidney enzymes were most marked, thus indicating a primary renal dysfunction.
Ngaha
E O
EO
Department of Biochemistry, Obafemi Awolowo University, Ile-Ife, Nigeria.
Akanji
M A
MA
Madusolumuo
M A
MA
D000135:Acid Phosphatase / Q000097:blood / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism*; D000818:Animals; D002738:Chloroquine / Q000494:pharmacology / Q000633:toxicity*; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D002738:Chloroquine; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase