title: Effect of a high-intensity static magnetic field on sciatic nerve regeneration in the rat.
abstract: The effect of a high-intensity static magnetic field on peripheral nerve regeneration is evaluated in rat sciatic nerve. Forty-four rats underwent sciatic nerve repair using polyethylene nerve guides. Postoperatively, the animals were exposed to a 1-tesla magnetic field for 12 hours per day for 4 weeks with appropriate controls. Our results demonstrate that a 1-tesla static magnetic field has no statistically significant effect on nerve regeneration as determined by myelinated axon counts and electrophysiologic studies. Also, the specific orientation of the sciatic nerve with respect to the magnetic field has no influence on axonal growth or nerve conduction. Periods of restraint of 12 hours per day for 4 weeks significantly inhibit weight gain but have no effect on peripheral nerve regeneration.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Lahey Clinic Medical Center, Burlington, Mass.
authors.forename: P G
authors.initials: PG
authors.lastname: Cordeiro
authors.forename: B R
authors.initials: BR
authors.lastname: Seckel
authors.forename: C D
authors.initials: CD
authors.lastname: Miller
authors.forename: P T
authors.initials: PT
authors.lastname: Gross
authors.forename: R E
authors.initials: RE
authors.lastname: Wise
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D004574:Electromagnetic Fields; D055590:Electromagnetic Phenomena; D004594:Electrophysiology; D008297:Male; D009416:Nerve Regeneration / Q000528:radiation effects*; D011840:Radiation, Nonionizing; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000502:physiology*; D013997:Time Factors