title: Gender-related differences in cardiac response to supine exercise assessed by radionuclide angiography.
abstract: This study examines the recently reported gender differences in cardiac responses to exercise. The study group consisted of 192 men and 67 women with a low probability of coronary artery disease who underwent supine exercise radionuclide angiography. Men had a lower rest ejection fraction than that of women (0.63 versus 0.66, p = 0.02) and greater increases in ejection fraction with exercise (0.08 versus 0.02, p = 0.0001). The slope relating ejection fraction to metabolic equivalents of exercise (METs) was greater (p = 0.004) for men, even after adjustment for differences in rest ejection fraction and end-diastolic volume index. Compared with men, women had a smaller rest end-diastolic volume index (87 versus 97 ml/m2, p = 0.003) and a greater increase in end-diastolic volume index with exercise (6 versus -2 ml/m2, p = 0.002). The slope relating end-diastolic volume to METs was greater for women, even after adjustment for differences in rest end-diastolic volume index and peak work load. There are clear gender differences in the supine exercise response of ejection fraction and end-diastolic volume that are not explained by differences in exercise capacity.
authors.affiliation: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
authors.forename: P C
authors.initials: PC
authors.lastname: Hanley
authors.forename: A R
authors.initials: AR
authors.lastname: Zinsmeister
authors.forename: I P
authors.initials: IP
authors.lastname: Clements
authors.forename: A A
authors.initials: AA
authors.lastname: Bove
authors.forename: M L
authors.initials: ML
authors.lastname: Brown
authors.forename: R J
authors.initials: RJ
authors.lastname: Gibbons
mesh_terms: D000328:Adult; D001794:Blood Pressure; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D011875:Radionuclide Angiography; D012737:Sex Factors; D013318:Stroke Volume; D013484:Supination