Limitations of flow cytometric DNA analysis for the diagnosis of bladder cancer.
Flow cytometric analysis was done on exfoliated urothelial cells from 11 control patients and 31 patients with transitional cell carcinoma: 9 grade I, 11 grade II, and 11 grade III. The determination of aneuploidy by DNA analysis did not provide identification of low-grade tumor cells. Other flow cytometric parameters of cellular change such as cell size, nuclear size, nuclear/cytoplasmic ratio, or cell refractivity may provide better identification of low-grade lesions.
Boileau
M A
MA
Department of Surgery, Medical School, University of Texas Health Science Center-Houston.
Swartz
D
D
Schmidt
K L
KL
Schmidt
W A
WA
D002295:Carcinoma, Transitional Cell / Q000175:diagnosis* / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry; D006801:Humans; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology
D004273:DNA, Neoplasm