title: Endoscopic diagnosis of reflux esophagitis by the dye-spraying method.
abstract: Twenty-one patients (13 patients after gastric surgery and 8 patients with hiatus hernia or other esophageal disease) in whom reflux esophagitis had been diagnosed by standard endoscopy, and who had undergone Lugol-spraying endoscopy, were reviewed. Ninety-two biopsy specimens were obtained from the esophageal mucosa under direct vision and stained with hematoxylineosin and PAS. The coincidence rate of the findings of dye-spraying endoscopy with histological findings was 89.9% (80/89), as opposed to 69.7% (62/89) attained by standard endoscopy (p less than 0.001), indicating that Lugol-spraying endoscopy is highly compatible with histology. Of 34 biopsy specimens showing papillary hyperplasia, 18 (52.9%) were stained unevenly and lightly, and 14 (41.2%) evenly and lightly. Of nine biopsy specimens showing epithelial regeneration, eight (88.9%) were unstained. All 26 biopsy specimens with erosion/ulcer were also unstained. It is concluded that Lugol-spraying endoscopy is of value in diagnosing reflux esophagitis, especially in determining the intensity and extent of the disease.
authors.affiliation: Second Department of Surgery, Kumamoto University Medical School, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Misumi
authors.forename: H
authors.initials: H
authors.lastname: Kondou
authors.forename: A
authors.initials: A
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Arima
authors.forename: U
authors.initials: U
authors.lastname: Honmyou
authors.forename: K
authors.initials: K
authors.lastname: Baba
authors.forename: M
authors.initials: M
authors.lastname: Akagi
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D004942:Esophagitis, Peptic / Q000175:diagnosis* / Q000473:pathology; D004945:Esophagoscopy / Q000379:methods*; D004947:Esophagus / Q000473:pathology; D005260:Female; D006801:Humans; D007454:Iodides; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology
chemical_list: D007454:Iodides; C010389:Lugol's solution