title: Support for adrenaline-hypertension hypothesis: 18 hour pressor effect after 6 hours adrenaline infusion.
abstract: In a double blind, crossover study 6 h infusions of adrenaline (15 ng/kg/min; 1 ng = 5.458 pmol), noradrenaline (30 ng/kg/min; 1 ng = 5.911 pmol), and a 5% dextrose solution (5.4 ml/h), were given to ten healthy volunteers in random order 2 weeks apart. By means of intra-arterial ambulatory monitoring the haemodynamic effects were followed for 18 h after the infusions were stopped. Adrenaline, but not noradrenaline, caused a delayed and protracted pressor effect. Over the total postinfusion period systolic and diastolic arterial pressure were 6 (SEM 2)% and 7 (2)%, respectively, higher than after dextrose infusion (ANOVA, p less than 0.001). Thus, "stress" levels of adrenaline (230 pg/ml) for 6 h cause a delayed and protracted pressor effect. These findings are strong support for the adrenaline-hypertension hypothesis in man.
authors.affiliation: Department of Internal Medicine I, Erasmus University Rotterdam, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: Blankestijn
authors.forename: A J
authors.initials: AJ
authors.lastname: Man in't Veld
authors.forename: J
authors.initials: J
authors.lastname: Tulen
authors.forename: A H
authors.initials: AH
authors.lastname: van den Meiracker
authors.forename: F
authors.initials: F
authors.lastname: Boomsma
authors.forename: P
authors.initials: P
authors.lastname: Moleman
authors.forename: H J
authors.initials: HJ
authors.lastname: Ritsema van Eck
authors.forename: F H
authors.initials: FH
authors.lastname: Derkx
authors.forename: P
authors.initials: P
authors.lastname: Mulder
authors.forename: S J
authors.initials: SJ
authors.lastname: Lamberts
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005947:Glucose / Q000008:administration & dosage; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage / Q000097:blood; D012083:Renin / Q000097:blood
chemical_list: D012083:Renin; D005947:Glucose; D009638:Norepinephrine; D004837:Epinephrine