Longitudinal changes in cranial base angulation in mandibulofacial dysostosis.
Longitudinal measures of cranial base angulation (nasion-sella-basion angle; N-S-Ba) were obtained in 24 patients with mandibulofacial dysostosis (MFD), with records available over time spans ranging from 2 years to 29 years. Initial measurements, obtained at ages ranging from 1 month to 13 years, 6 months, indicated basilar kyphosis (N-S-Ba less than 120 degrees) in five patients. Twenty-one patients showed increasing flexure of the cranial base angle (CBA) over time, eight to such a degree that their initially normal CBAs eventually fell into the kyphotic range. At the time of the final available records (age range 4 years, 0 months to 29 years, 2 months), a total of 54 percent of patients thus fell into the kyphotic range. These results point to the time-dependent nature of the appearance of abnormal CB angulation in some patients. In addition, there was a predominance of males in those patients showing significant change in cranial base angulation over time.
Peterson-Falzone
S J
SJ
Center for Craniofacial Anomalies, University of California, San Francisco.
Figueroa
A A
AA
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000473:pathology*; D002508:Cephalometry; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D008342:Mandibulofacial Dysostosis / Q000473:pathology*; D012737:Sex Factors; D012886:Skull / Q000033:anatomy & histology*