Activation in vivo of a major antisuppressor T-cell pathway immediately after immunization. II. T-cell requirements for its expression.
Immunogens activate in vivo within 3-6 hr after injection a new and hitherto unrecognized T-cell pathway which interferes with T-cell suppression, therefore called antisuppression. An important soluble mediator with antisuppressor activity is detected in the serum of immunized animals within 3-6 hr. The mediator represents a unique form of complexes of Ig and antigen. The antisuppressor function of the complexes does not represent a direct "neutralizing" effect of the complexes on the effector T suppressor cells. The antisuppressor complexes activate an Ly2+ T cell which, with the interaction of an Ly123+ T cell, blocks completely T-suppressor-cell function. The biological significance of the T antisuppressor pathway is discussed.
Lee
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Paraskevas
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Maeba
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D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D001798:Blood Proteins / Q000502:physiology; D002450:Cell Communication; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007108:Immune Tolerance; D007116:Immunization, Passive; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D010641:Phenotype; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology*; D013997:Time Factors
D000911:Antibodies, Monoclonal; D001798:Blood Proteins; D000949:Histocompatibility Antigens Class II; C011850:immunoenhancing factor