Genetic variation of haptoglobin and transferrin in relation to DNA content and stage in renal cell carcinoma.
Four genetic marker systems were investigated in 102 patients with renal cell carcinoma. The previously observed excess of the transferrin (TF) variant C3 among male patients was confirmed. Interestingly, an excess of TFC3 and a deficit of the haptoglobin heterozygote, HP2-1, were associated with diploid tumor DNA content and Stage I, particularly in male patients. The results are discussed in terms of a possible genetic influence on tumor progression.
Fröhlander
N
N
Department of Medical Genetics, University of Umeå, Sweden.
Ljungberg
B
B
Roos
G
G
D002292:Carcinoma, Renal Cell / Q000032:analysis / Q000235:genetics* / Q000473:pathology; D003176:Complement C3 / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D005260:Female; D005819:Genetic Markers / Q000032:analysis; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000032:analysis / Q000235:genetics* / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D010641:Phenotype; D014168:Transferrin / Q000235:genetics*; D014809:Vitamin D-Binding Protein / Q000032:analysis
D003176:Complement C3; D004273:DNA, Neoplasm; D005819:Genetic Markers; D006242:Haptoglobins; D014168:Transferrin; D014809:Vitamin D-Binding Protein