Effect of vitamin K3 on macrophage functions and intracellular calcium.
1. The effect of vitamin(vit) K3 on guinea-pig macrophage functions was studied. 2. Vit K3 inhibited macrophage locomotion, phagocytosis and lysosomal enzyme release. 3. Vit K3 inhibited the rise in the intracellular free calcium level induced by stimuli at the concentration at which vit K3 suppressed functions. 4. These results suggest that vit K3 inhibits macrophage functions through the interference with the mobilization of intracellular calcium.
Koyano
H
H
Department of Biochemistry, School of Medicine, Juntendo University, Tokyo, Japan.
Someya
A
A
Nagaoka
I
I
Yamashita
T
T
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002448:Cell Adhesion / Q000187:drug effects; D002449:Cell Aggregation / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010587:Phagocytosis / Q000187:drug effects; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D014812:Vitamin K / Q000494:pharmacology*
D013438:Sulfhydryl Compounds; D013481:Superoxides; D014812:Vitamin K; D002118:Calcium