[Effect of diazepam, carbamazepine, sodium valproate and their combinations with vitamin preparations on epileptic activity].
The anticonvulsive action of diazepam, carbamazepine, sodium valproate and their combinations with pyridoxal-5-phosphate, nicotinamide, and alpha-tocopherol were investigated in acute experiments on mice with corazole-induced seizures. Diazepam (0.5 mg/kg), carbamazepine (50 mg/kg) and sodium valproate (200 mg/kg) were shown to reduce convulsive intensity and lethality. Vitamins nicotinamide (250 mg/kg), pyridoxal-5-phosphate (10 mg/kg) and alpha-tocopherol (100 mg/kg) potentiated anticonvulsive action of the above antiepileptic drugs. The results of the investigation suggest the efficacy of pathogenetic therapy and give new evidence of the advisability of using vitamins in combination with synthetic anticonvulsive drugs.
Kryzhanovskiĭ
G N
GN
Shandra
A A
AA
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D008297:Male; D009536:Niacinamide / Q000627:therapeutic use; D010433:Pentylenetetrazole; D011732:Pyridoxal Phosphate / Q000627:therapeutic use; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D014635:Valproic Acid / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*
D000927:Anticonvulsants; D014815:Vitamins; D014810:Vitamin E; D009536:Niacinamide; D002220:Carbamazepine; D011732:Pyridoxal Phosphate; D014635:Valproic Acid; D003975:Diazepam; D010433:Pentylenetetrazole
Vliianie diazepama, karbamazepina, val'proata natriia i ikh sochetaniĭ s vitaminnymi preparatami na épilepticheskuiu aktivnost'.