Influence of absorbable and nonabsorbable lipids and lipidlike substances on drug bioavailability.
The influence of three diets (olestra, triglyceride oil, and water) on the bioavailability of a single dose of propranolol, diazepam, norethindrone, and ethinyl estradiol was evaluated. For each drug the diets were randomly administered in a crossover fashion; a period of at least 14 days separated each of the drug studies. Blood samples were obtained before and after the oral administration of test drug and diet. Specific timing of blood samples varied for the respective drugs. AUCs were determined by the trapezoidal method. There were no statistical differences observed in the absorption of the various drugs evaluated in this study when administered with olestra, triglyceride oil, or water, except that the time to peak concentration of diazepam was significantly longer with the triglyceride oil than with olestra or water.
Roberts
R J
RJ
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville 22908.
Leff
R D
RD
D000328:Adult; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001682:Biological Availability; D003975:Diazepam / Q000493:pharmacokinetics; D004347:Drug Interactions; D004997:Ethinyl Estradiol / Q000493:pharmacokinetics; D005227:Fatty Acids; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009640:Norethindrone / Q000493:pharmacokinetics; D010938:Plant Oils / Q000494:pharmacology*; D011433:Propranolol / Q000493:pharmacokinetics; D013024:Soybean Oil / Q000494:pharmacology*; D013395:Sucrose / Q000031:analogs & derivatives* / Q000494:pharmacology; D014867:Water / Q000494:pharmacology
D000924:Anticholesteremic Agents; D005227:Fatty Acids; D010938:Plant Oils; D014867:Water; D004997:Ethinyl Estradiol; D013395:Sucrose; C013692:sucrose polyester; D013024:Soybean Oil; D011433:Propranolol; D003975:Diazepam; D009640:Norethindrone