The in vivo behavior of gentamicin-PMMA beads in the maxillofacial region.
Gentamicin-PMMA beads were placed in maxillofacial wounds of ten dogs, and gentamicin levels from wound drain sites, serum, and urine were measured by radioimmunoassay. The results indicate extremely high wound and modest urine levels (which decrease exponentially) concurrently with negligible serum levels of gentamicin. The results of this study of a highly vascularized area were similar to other studies in which beads were placed in avascular areas.
Alpert
B
B
Department of Oral and Maxillofacial Surgery, University of Louisville School of Dentistry, KY 40292.
Colosi
T
T
von Fraunhofer
J A
JA
Seligson
D
D
D000818:Animals; D004285:Dogs; D004322:Drainage; D004337:Drug Carriers; D005839:Gentamicins / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D008334:Mandible / Q000601:surgery*; D008437:Maxilla / Q000601:surgery*; D008768:Methylmethacrylates
D004337:Drug Carriers; D005839:Gentamicins; D008768:Methylmethacrylates; C030159:gentamicin-polymethylmethacrylate bead