[Suppression of Lewis carcinoma metastasis in mice by an interferon-inducing vasodilator curantil].
The intravascular (iv) or intramuscular (im) inoculations of a suspension of Lewis carcinoma cells induced metastatic tumor nodules in the lungs of C57Bl/6 mice. The administration of curantil (dipyridamole) (500 mg per 20 g-mouse, per os) once a week beginning one day after iv tumor cells inoculation (2 X 10(5) cells) reduced 4-fold the number of tumor nodules. The administration of curantil one day after im tumor cells inoculation (2 X 10(6) cells) reduced 2-fold the number of tumor nodules. The combined treatment of curantil (4-, 10-days after inoculation) and well-known inducer of interferon poly I:poly C (50 mg per 20 g-mouse, 1-, 7-, 14-days after inoculation tumor cells) had no synergistic effect.
Fedorovskaia
E O
EO
Pelevina
I I
II
Afanas'ev
G G
GG
Ershov
F I
FI
Grigorian
S S
SS
D000818:Animals; D004176:Dipyridamole / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D007369:Interferon Inducers / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D011070:Poly I-C / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors
D007369:Interferon Inducers; D004176:Dipyridamole; D011070:Poly I-C
Podavlenie metastazirovaniia kartsinomy L'iuis u mysheĭ vazodilatatorom kurantilom, indutsiruiushchim interferon.