title: Fatal haemopathological consequences of general anaesthesia.
abstract: A previously healthy 63-yr-old female died following an anaphylactoid response to anaesthesia with thiopentone and suxamethonium. Postmortem findings strongly suggested that disseminated intravascular coagulation played a significant role in her death. The local mechanism behind the reaction is unknown, but the formation of thiopentone-suxamethonium colloid aggregates during induction, may have led to "aggregate anaphylaxis".
authors.affiliation: Department of Anaesthetics, Royal Hallamshire Hospital, Sheffield.
authors.forename: P J
authors.initials: PJ
authors.lastname: Wright
authors.forename: J R
authors.initials: JR
authors.lastname: Shortland
authors.forename: J D
authors.initials: JD
authors.lastname: Stevens
authors.forename: M A
authors.initials: MA
authors.lastname: Parsons
authors.forename: J
authors.initials: J
authors.lastname: Watkins
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced*; D000768:Anesthesia, General / Q000009:adverse effects*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013390:Succinylcholine / Q000009:adverse effects*; D013874:Thiopental / Q000009:adverse effects*
chemical_list: D013390:Succinylcholine; D013874:Thiopental