Effects of antimuscarinic agents, H2-blockers and omeprazole on rat chronic gastric ulcer after long- and short-term administration.
Two series of experiments were performed on rat chronic ulcer in order to assess the possible curative and mucosal protective properties of 2 week treatments, or the preventive properties of 4 week treatments with antisecretory agents, acting with different mechanisms of action. At the end of the treatments the gastric secretory and motor responsiveness to a gastrin-like stimulus was simultaneously evaluated. The results support the view that antimuscarinic agents as well as H2-blockers cannot be defined as protective and that after a 4 week treatment they can induce modifications of gastric functions.
Chiavarini
M
M
Institute of Pharmacology and Pharmacognosy, University of Parma, Italy.
Morini
G
G
Barocelli
E
E
Impicciatore
M
M
Bordi
F
F
D000284:Administration, Oral; D000818:Animals; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000187:drug effects; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D009853:Omeprazole / Q000627:therapeutic use*; D010276:Parasympatholytics / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D013997:Time Factors
D006635:Histamine H2 Antagonists; D010276:Parasympatholytics; D009853:Omeprazole