title: Cephaloridine resistance in gram-negative bacteria isolated in Scotland.
abstract: The incidence of cephaloridine resistance (minimum inhibitory concentration, MIC greater than 8 mg L-1) in isolates from urinary tract infections was 45.1% in Glasgow, 22.6% in Dundee and 25.9% in Edinburgh. The incidence of ampicillin resistance (MIC greater than 8 mg L-1) was even higher:- being 45.2% in Dundee and 48.5% in Edinburgh. In Glasgow, the incidence was 71.9% which is the highest proportion of ampicillin resistance reported in the United Kingdom. The cephaloridine resistant strains were examined for beta-lactamase production. Amongst these strains 50.8% produced only a chromosomal beta-lactamase, whereas 47.9% produced beta-lactamases which were potentially plasmid-mediated on the basis of biochemical tests. Only 1% of the resistant strains produced no detectable beta-lactamase.
authors.affiliation: Department of Bacteriology, Medical School, University of Edinburgh, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Reid
authors.forename: I N
authors.initials: IN
authors.lastname: Simpson
authors.forename: P B
authors.initials: PB
authors.lastname: Harper
authors.forename: S G
authors.initials: SG
authors.lastname: Amyes
mesh_terms: D000668:Ampicillin Resistance; D002509:Cephaloridine / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D006801:Humans; D007525:Isoelectric Focusing; D008826:Microbial Sensitivity Tests; D012606:Scotland; D014552:Urinary Tract Infections / Q000382:microbiology; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism
chemical_list: D001618:beta-Lactamases; D002509:Cephaloridine