title: Angiotensin II-induced rhythmic jaw movements in the ketamine-anesthetized guinea pig.
abstract: The EMG activity of the left anterior digastric muscle as well as associated jaw movements were studied in ketamine-anesthetized guinea pigs that had received i.v. infusions of angiotensin II (ANG-II). Rhythmic jaw movements with two distinct movement profiles were associated with ANG-II infusion. One movement profile was typified by vertical jaw opening and closing movements with little or no associated horizontal movement. The second rhythmical jaw movement profile was unlike the first in that jaw closing was accompanied by a significant horizontal deflection of the jaw. Both jaw movement profiles were similar in that little or no horizontal movement occurred during jaw opening. Tongue protrusions were also observed during jaw opening in both cases. The results show that ANG-II induces rhythmic jaw movements in anesthetized guinea pigs. ANG-II-induced jaw movement profiles and digastric muscle EMG activity are similar to those seen after an i.v. injection of apomorphine in the anesthetized guinea pig, and to those associated with lapping in the awake animal.
authors.affiliation: Department of Oral Biology, School of Dentistry, University of California, Los Angeles 90024.
authors.forename: G E
authors.initials: GE
authors.lastname: Gerstner
authors.forename: L J
authors.initials: LJ
authors.lastname: Goldberg
authors.forename: K
authors.initials: K
authors.lastname: De Bruyne
mesh_terms: D000758:Anesthesia; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D004326:Drinking; D006168:Guinea Pigs; D007568:Jaw / Q000187:drug effects / Q000502:physiology*; D007649:Ketamine; D008410:Masticatory Muscles / Q000187:drug effects / Q000502:physiology*; D009068:Movement / Q000187:drug effects*
chemical_list: D000804:Angiotensin II; D007649:Ketamine