Neuronal loss in lumbar dorsal root ganglia after proximal compared to distal sciatic nerve resection: a quantitative study in the rat.
The effects of unilateral sciatic nerve resections at proximal (thigh) or distal (proximal calf) locations on L4-L6 dorsal root ganglion (DRG) neuronal numbers have been studied in adult rats. Proximal nerve resection gave rise to a mean DRG neuronal loss of 27%, whereas in distal lesions a mean cell loss of 7% was found. This difference in cell loss between proximal and distal sciatic nerve resections is highly significant (P less than 0.001).
Ygge
J
J
Department of Anatomy, Karolinska Institutet, Stockholm, Sweden.
D000818:Animals; D002452:Cell Count; D005260:Female; D005727:Ganglia, Spinal / Q000166:cytology / Q000502:physiology*; D009410:Nerve Degeneration; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000166:cytology / Q000502:physiology*