title: Effect of glucocorticoid deficiency on arterial pressure in conscious spontaneously hypertensive rats.
abstract: The effect of selective glucocorticoid or mineralocorticoid deficiency upon arterial pressure was evaluated in unanesthetized adult spontaneously hypertensive rats (SHR). Adrenalectomized SHR were replaced with 6 micrograms/24 h aldosterone (ALDO), 10 microgram/24 h dexamethasone (DEX), or both aldosterone and dexamethasone (ALDO + DEX) by IP osmotic mini-pumps. These were compared to sham-operated SHR (SHAM) and adrenalectomized SHR given no steroid replacement (ADX). Drinking fluid for all groups was 1% NaCl + 2.5% glucose. Six days after adrenalectomy, intra-arterial mean arterial pressure (MAP) fell from 174 +/- 2 to 149 +/- 6 mm Hg in ALDO (n = 8, P less than .01) and from 179 +/- 4 to 125 +/- 4 in ADX (n = 6, P less than .01). In contrast, MAP rose in SHAM from 171 +/- 4 to 179 +/- 5 mm Hg (n = 7, P less than .01), in ALDO + DEX from 161 +/- 3 to 184 +/- 4 mm Hg (n = 7, P less than .01), and in DEX from 162 +/- 2 to 181 +/- 4 mm Hg (n = 7, P less than .01). The results indicate that when diet salt intake is high, glucocorticoid action is necessary for the full expression of hypertension in adult SHR.
authors.affiliation: Department of Medicine, Mount Sinai School of Medicine, City University of New York.
authors.forename: Y
authors.initials: Y
authors.lastname: Yagil
authors.forename: M
authors.initials: M
authors.lastname: Levin
authors.forename: L R
authors.initials: LR
authors.lastname: Krakoff
mesh_terms: D000315:Adrenalectomy; D000450:Aldosterone / Q000008:administration & dosage; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003907:Dexamethasone / Q000008:administration & dosage; D005938:Glucocorticoids / Q000502:physiology*; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008901:Mineralocorticoids / Q000502:physiology; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D005938:Glucocorticoids; D008901:Mineralocorticoids; D000450:Aldosterone; D003907:Dexamethasone