title: [Chloditan-induced changes in lipid peroxidation in the adrenals of dogs and guinea pigs].
abstract: The effect of adrenocorticolytic drug chloditan (1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane;) on the content and the rate of lipid peroxidation in dog and guinea pig adrenals was studied. In adrenals of dogs and guinea the amount of malondialdehyde (MDA) was increased. In vitro spontaneous lipid peroxidation was delayed in adrenal homogenate of DDD-treated dogs. Spontaneous lipid peroxidation in adrenal homogenate was not decreased by feeding DDD in the guinea pig. DDD consumption did not affect on lipid peroxidation promoted by ascorbic acid and ferrous iron. The accumulation of MDA in dog and guinea pig adrenal homogenates was inhibited by NADPH.
authors.forename: I S
authors.initials: IS
authors.lastname: Chelnakova
authors.forename: N D
authors.initials: ND
authors.lastname: Tron'ko
authors.forename: A S
authors.initials: AS
authors.lastname: Mikosha
mesh_terms: D000311:Adrenal Glands / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D004285:Dogs; D004579:Electron Transport / Q000187:drug effects; D006168:Guinea Pigs; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000032:analysis; D008939:Mitotane / Q000494:pharmacology*; D009249:NADP / Q000494:pharmacology
chemical_list: D008315:Malondialdehyde; D009249:NADP; D008939:Mitotane; D001205:Ascorbic Acid
vernacular_title: Vyzyvaemye khloditanom izmeneniia perekisnogo okisleniia lipidov v nadpochechnikakh sobak i morskikkh svinok.