title: Effects of oxygen deprivation on incubated rat soleus muscle.
abstract: Isolated soleus muscle deprived of oxygen produces more lactate and alanine than oxygen-supplied muscle. Oxygenated muscle synthesized glutamine, while anoxic muscle used this amino acid. Oxygen deprivation decreased adenine nucleotides leading to the efflux of nucleosides. Protein synthesis and degradation responded differently to anoxia. Synthesis almost completely ceased, while proteolysis increased. Therefore, protein degradation in soleus muscle is enhanced when energy supplies and oxygen tension are low.
authors.affiliation: Department of Biochemistry, University of Arizona, Tucson 85724.
authors.forename: J M
authors.initials: JM
authors.lastname: Fagan
authors.forename: M E
authors.initials: ME
authors.lastname: Tischler
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism; D000409:Alanine / Q000096:biosynthesis; D000818:Animals; D004734:Energy Metabolism; D005973:Glutamine / Q000096:biosynthesis; D007700:Kinetics; D007773:Lactates / Q000096:biosynthesis; D019344:Lactic Acid; D008297:Male; D009124:Muscle Proteins / Q000096:biosynthesis / Q000378:metabolism; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D009705:Nucleosides / Q000378:metabolism; D010100:Oxygen / Q000494:pharmacology / Q000502:physiology*; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats
chemical_list: D000227:Adenine Nucleotides; D007773:Lactates; D009124:Muscle Proteins; D009705:Nucleosides; D010725:Phosphocreatine; D005973:Glutamine; D019344:Lactic Acid; D000409:Alanine; D010100:Oxygen