title: Brain penetration of orally administered sodium pyroglutamate.
abstract: The absorption and brain penetration of [3H]pyroglutamate was determined after oral administration to rats. Gas-liquid chromatography of the methylated derivatives followed by mass fragmentometry was used to analyse the plasma and brain levels of pyroglutamate. [3H]Pyroglutamate was separated from other labelled compounds by thin layer chromatography. The administration of 500 mg kg-1 [3H]pyroglutamate resulted in a 30-fold increase in plasma levels and a doubling in the brain levels. Over 60% of the cerebral radioactivity was present as [3H]pyroglutamate demonstrating that pyroglutamate is not only well absorbed but also penetrates in significant amounts into the brain.
authors.affiliation: Faculty of Pharmacy, University of Montpellier, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Chanal
authors.forename: M
authors.initials: M
authors.lastname: Audran
authors.forename: M T
authors.initials: MT
authors.lastname: Sicard
authors.forename: M
authors.initials: M
authors.lastname: Briley
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D011760:Pyrrolidinones / Q000493:pharmacokinetics*; D011761:Pyrrolidonecarboxylic Acid / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011760:Pyrrolidinones; D011761:Pyrrolidonecarboxylic Acid