title: Synthesis and pharmacological effect of substituted phenyl-4-(2-chloroethyl)tetrahydro-1,4-oxazine hydrochlorides.
abstract: Substituted phenyl-4-(2-chloroethyl)tetrahydro-1,4-oxazine hydrochlorides were prepared by treating the corresponding amino alcohols with thionyl chloride. Since these compounds are considered to be monofunctional 2-haloalkylamine type agents, they were tested for possible alpha-adrenergic blocking activity using the rat anococcygeus muscle. The pharmacological action of this series of compounds is discussed.
authors.affiliation: Department of Pharmacology and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, Sudan.
authors.forename: S S
authors.initials: SS
authors.lastname: Daoud
authors.forename: S A
authors.initials: SA
authors.lastname: Osman
authors.forename: M A
authors.initials: MA
authors.lastname: Karrar
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D009025:Morpholines / Q000138:chemical synthesis* / Q000494:pharmacology; D009132:Muscles / Q000187:drug effects; D051381:Rats
chemical_list: D000316:Adrenergic alpha-Agonists; D009025:Morpholines