Mitomycin C analogues with a substituted hydrazine at position 7. Synthesis, spectral properties, and biological activity.
A select number of mitomycin C derivatives with a substituted hydrazine group at position 7 were synthesized and tested for antineoplastic activity by using an in vivo test with murine P388 leukemia. Several of the adducts displayed activity comparable to that of mitomycin C. The X-ray-determined crystal structure of one of the derivatives (3f) is reported.
Sawhney
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KN
Department of Chemistry, University of Houston, Texas 77204-5641.
Kohn
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D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008937:Mitomycins / Q000138:chemical synthesis* / Q000627:therapeutic use; D008958:Models, Molecular; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D008937:Mitomycins