Lack of toxicity of a topical recombinant interferon alpha.
We evaluated the potential ocular surface toxicity of a recombinant interferon-alpha (IFN alpha) preparation on rabbit eyes. Topical application of this interferon (1 x 10(6) U/day in each eye) for 6 weeks produced no discernible conjunctival or corneal abnormalities on clinical, histopathologic, or ultrastructural evaluations. We believe that this recombinant IFN alpha preparation is not toxic to the ocular surface of rabbits.
Smith
M
M
Estelle Doheny Eye Foundation, Department of Ophthalmology, University of Southern California, Los Angeles.
Trousdale
M D
MD
Rao
N A
NA
Robin
J B
JB
D000818:Animals; D003315:Cornea / Q000187:drug effects*; D004848:Epithelium / Q000187:drug effects; D007370:Interferon Type I / Q000633:toxicity*; D008297:Male; D008854:Microscopy, Electron; D009883:Ophthalmic Solutions; D011817:Rabbits; D011994:Recombinant Proteins
D007370:Interferon Type I; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins