Plasma amino acids in relation to metabolic control in insulin-dependent diabetic children.
The influence of metabolic control (estimated by blood glucose, 3-hydroxybutyrate and glycosylated hemoglobin levels) on plasma amino acids was determined in a group of 56 insulin-dependent diabetic children. A multiple correlation analysis revealed significant positive partial correlations between most amino acids and blood glucose. Alanine, methionine, tyrosine, phenylalanine and arginine showed negative partial correlations to the 3-hydroxybutyrate level. The results are consistent with the postulate that ketone body inhibition of muscle proteolysis is one of the factors regulating substrate flows during insulin deficiency.
Hagenfeldt
L
L
Department of Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden.
Dahlquist
G
G
Persson
B
B
D020155:3-Hydroxybutyric Acid; D000293:Adolescent; D000596:Amino Acids / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D008297:Male
D020155:3-Hydroxybutyric Acid; D000596:Amino Acids; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D006885:Hydroxybutyrates