Cerebrovascular autoregulation is resistant to calcium channel blockade with nimodipine.
In normal baboons cerebrovascular resistance changed along with blood pressure to maintain blood flow constant. This 'autoregulation' was not significantly altered in animals treated with a dose of the calcium channel blocker nimodipine causing selective cerebral vasodilation.
McCalden
T A
TA
Cerebrovascular Research Laboratory, VA Medical Center, Houston, Texas.
Nath
R G
RG
D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006706:Homeostasis / Q000187:drug effects*; D009553:Nimodipine / Q000494:pharmacology*; D010215:Papio; D014655:Vascular Resistance / Q000187:drug effects; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D009553:Nimodipine