title: Phase II study of a new alkylating agent (PTT-119) in resistant-relapsed non-Hodgkin's lymphomas.
abstract: In a phase II study we evaluated the effect and toxicity of a new alkylating agent, PTT-119, in 26 patients with non-Hodgkin's lymphomas (NHL) resistant to or relapsed after other chemotherapy. PTT was scheduled by escalating the dose from 2.0 to 3.3 mg/kg every 3 weeks. Among 21 evaluable patients with NHL, 12 (57%) showed a good response (CR + PR) to PTT-119. Tolerance was acceptably good; no major side effects related to liver, cardiac, or renal toxicity were recorded. The most commonly recorded side effects were nausea and vomiting, alopecia, and phlebitis; diarrhea and drug-related fever were rarely seen. This report indicates a potential usefulness for PTT-119, a non-cross-resistant alkylating agent, in the treatment of NHL.
authors.affiliation: Institute of Hematology, L. e A. Seragnoli, University of Bologna, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Tura
authors.forename: P
authors.initials: P
authors.lastname: Mazza
authors.forename: F
authors.initials: F
authors.lastname: Gherlinzoni
authors.forename: P L
authors.initials: PL
authors.lastname: Zinzani
authors.forename: G
authors.initials: G
authors.lastname: Poletti
authors.forename: G
authors.initials: G
authors.lastname: Visani
authors.forename: R M
authors.initials: RM
authors.lastname: Lemoli
authors.forename: M
authors.initials: M
authors.lastname: Cavo
authors.forename: P
authors.initials: P
authors.lastname: Galieni
authors.forename: C
authors.initials: C
authors.lastname: Tassi
mesh_terms: D000328:Adult; D000368:Aged; D000477:Alkylating Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009588:Nitrogen Mustard Compounds / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000477:Alkylating Agents; D000970:Antineoplastic Agents; D009588:Nitrogen Mustard Compounds; C038259:ambamustine