Dextromethorphan protects retina against ischemic injury in vivo.
Retinal ischemia was induced in rabbits by increasing intraocular pressure above systolic blood pressure for 60 or 75 minutes, and retinal function was monitored by electroretinography. Pretreatment with intravenous dextromethorphan, a nonprescription antitussive and selective antagonist of N-methyl-D-aspartate receptors, enhanced greatly the post-ischemic recovery of b-wave amplitude. Dextromethorphan may prove to be useful clinically in the management of retinal ischemic disease.
Yoon
Y H
YH
Department of Ophthalmology, Stanford University School of Medicine, CA 94305.
Marmor
M F
MF
D000818:Animals; D003915:Dextromethorphan / Q000008:administration & dosage*; D004596:Electroretinography; D007262:Infusions, Intravenous; D007511:Ischemia / Q000473:pathology / Q000517:prevention & control*; D007981:Levorphanol / Q000031:analogs & derivatives*; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D012164:Retinal Diseases / Q000517:prevention & control; D012171:Retinal Vessels; D013997:Time Factors
D007981:Levorphanol; D003915:Dextromethorphan