title: On thymidine incorporation by the cultured chick pineal gland.
abstract: Explanted chick pineal glands exhibited a cycle in thymidine incorporation when cultured either under a cycle of illumination or in constant darkness. This cycle appeared to be entrained to the light cycle under which the birds were maintained. The incorporation reflected gene replication in a small fraction of the cell population that was largely, but not entirely, located in the stroma of the gland. Glands cultured with colchicine for 28 h contained a very small number of cells showing metaphase chromosomes.
authors.affiliation: Biochemistry Department, Dalhousie University, Halifax, N.S., Canada.
authors.forename: S D
authors.initials: SD
authors.lastname: Wainwright
authors.forename: L K
authors.initials: LK
authors.lastname: Wainwright
authors.forename: C J
authors.initials: CJ
authors.lastname: Lucarotti
mesh_terms: D000818:Animals; D002645:Chickens; D002940:Circadian Rhythm; D003078:Colchicine / Q000494:pharmacology; D004261:DNA Replication; D008027:Light; D009924:Organ Culture Techniques; D010870:Pineal Gland / Q000187:drug effects / Q000378:metabolism*; D013936:Thymidine / Q000493:pharmacokinetics*
chemical_list: D003078:Colchicine; D013936:Thymidine