title: Taq I polymorphism of HLA class I genes in an ankylosing spondylitis family.
abstract: A 3.5-kb HLA class I fragment is polymorphic in an ankylosing spondylitis (AS) family. All B27 AS patients show the 3.5-kb band, which is also present in B12 AS patients in this family. When hybridized with an HLA-B-specific probe, the polymorphic band is revealed in B12 patients, but not in B27 patients.
authors.affiliation: Laboratory of Molecular Genetics, National Blood Transfusion Center Institute, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Lucotte
authors.forename: F
authors.initials: F
authors.lastname: Huetz
authors.forename: M
authors.initials: M
authors.lastname: Mariotti
authors.forename: B
authors.initials: B
authors.lastname: Cavelier
authors.forename: P
authors.initials: P
authors.lastname: Deshayes
authors.forename: B
authors.initials: B
authors.lastname: Amor
mesh_terms: D000483:Alleles; D015342:DNA Probes; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D015698:Genomic Library; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000276:immunology
chemical_list: D015342:DNA Probes; D006680:HLA Antigens; D015235:HLA-B Antigens; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases