Protective role of serum antibody in immunity to chlamydial genital infection.
Female guinea pigs were injected intraperitoneally with pooled immunoglobulin derived from animals immunized to the chlamydial agent of guinea pig inclusion conjunctivitis. Genital infections in animals receiving pooled immunoglobulin from immune animals were markedly decreased with regard to the number of inclusions detected compared with control animals. These data indicated that serum-derived antibody was able to provide a degree of protection against a chlamydial genital tract infection.
Rank
R G
RG
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205.
Batteiger
B E
BE
D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage*; D002690:Chlamydia Infections / Q000276:immunology* / Q000517:prevention & control; D005260:Female; D005831:Genital Diseases, Female / Q000276:immunology* / Q000517:prevention & control; D006168:Guinea Pigs; D007116:Immunization, Passive; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007274:Injections, Intraperitoneal
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G