The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo.
A gradient in concentration of the protein product of the bicoid gene is a determinant of the anterior-posterior axis of Drosophila embryos. By binding upstream of the segmentation gene hunchback the bicoid protein controls its transcription, thereby translating maternal pattern-generating information into differential activation of zygotic gene expression.
Driever
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W
Max Planck Institut für Entwicklungsbiologie, Abteilung III Genetik, Tübingen, FRG.
Nüsslein-Volhard
C
C
D000818:Animals; D001483:Base Sequence; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D004625:Embryo, Nonmammalian / Q000502:physiology; D005796:Genes; D005809:Genes, Regulator; D018398:Homeodomain Proteins; D007301:Insect Hormones / Q000235:genetics* / Q000502:physiology; D008969:Molecular Sequence Data; D015183:Restriction Mapping; D015534:Trans-Activators; D014158:Transcription, Genetic
D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D007301:Insect Hormones; D015534:Trans-Activators; C056478:bcd protein, Drosophila