Gastric cytoprotection induced by prostaglandin-dopaminergic mechanism.
The cytoprotective effects on the gastric mucosa of the Bromocriptine, a peripheral dopaminergic receptor agonist compared with Misoprostol against ethanol-induced injury were studied. Pretreatment with SCH 23390 (a DA1 receptor antagonist) and Domperidone (a DA2 receptor antagonist), showed that Misoprostol was peripheral dopaminergic receptor dependent in the gastric cytoprotective mechanism, and that Bromocriptine was a selective peripheral DA2 receptor agonist in the gastric cytoprotection mechanism; as well as, indomethacin pretreatment, showed that peripheral DA2 receptors were endogenous prostaglandin dependent. In conclusion, a prostaglandin-dopaminergic mechanism was postulated in gastric cytoprotection.
Laudanno
O M
OM
Gastroenterology Division, Faculty of Medicine, Rosario, Argentina.
Bedini
O A
OA
San Miguel
P
P
Cesolari
J A
JA
D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001552:Benzazepines / Q000494:pharmacology*; D001971:Bromocriptine / Q000494:pharmacology*; D004294:Domperidone / Q000494:pharmacology*; D000431:Ethanol / Q000037:antagonists & inhibitors*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D016595:Misoprostol; D009336:Necrosis; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000494:pharmacology
D014150:Antipsychotic Agents; D001552:Benzazepines; D011954:Receptors, Dopamine; D016595:Misoprostol; D001971:Bromocriptine; D000431:Ethanol; D004294:Domperidone; D000527:Alprostadil