Effect of parthenin on mitochondrial oxidative phosphorylation.
The sesquiterpene lactone, 'parthenin' the toxic principle of the allergenic weed Parthenium hysterophorus, inhibited 'state 3' respiration and stimulated 'state 4' respiration in rat liver and kidney mitochondria as well as ATPase activity in the presence of Mg2+ ions. These properties indicate that the toxic action of parthenin may be related to its interference with oxidative phosphorylation.
Narasimhan
T R
TR
Harindranath
N
N
Kurup
C K
CK
Rao
P V
PV
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D012717:Sesquiterpenes / Q000494:pharmacology*; D014475:Uncoupling Agents
D012717:Sesquiterpenes; D014475:Uncoupling Agents; C022097:parthenin; D000251:Adenosine Triphosphatases