Ptosis and supranuclear downgaze paralysis.
A patient developed the unusual combination of a supranuclear downward gaze paralysis and bilateral ptosis. It was caused by a single midbrain glioma. Other ocular motor functions were intact. The neuropathologic examination showed a tumor growing mainly around the third ventricle and the aqueduct. The findings agree with recent experimental evidence that a network of neural elements involved in eyelid control lies in the supraoculomotor area immediately dorsal to the oculomotor nucleus.
Büttner-Ennever
J A
JA
Institute of Neuropathology, Ludwig Maximilian University of Munich, FRG.
Acheson
J F
JF
Büttner
U
U
Graham
E M
EM
Leonard
T J
TJ
Sanders
M D
MD
Russell
R R
RR
D000368:Aged; D001254:Astrocytoma / Q000150:complications / Q000473:pathology; D001763:Blepharoptosis / Q000150:complications* / Q000209:etiology / Q000473:pathology; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology; D005133:Eye Movements; D005260:Female; D005403:Fixation, Ocular; D006801:Humans; D009801:Oculomotor Muscles / Q000473:pathology; D010243:Paralysis / Q000150:complications* / Q000209:etiology / Q000473:pathology