A correlation between serum cholesterol and glycosylated hemoglobin in nondiabetic humans.
The relationship of serum cholesterol and average blood glucose as glycosylated hemoglobin was investigated in 43 nondiabetic subjects. Glycosylated hemoglobin correlated strongly with total cholesterol (r = .63, P less than .001). A significant negative partial correlation (r = -.25, P = .05) was seen between high-density lipoprotein cholesterol and glycosylated hemoglobin if total cholesterol was held constant. This negative partial correlation was much stronger when the analysis was limited to subjects with total cholesterol greater than 5.20 mmol/L (200 mg/dL, r = -.51, P = .006). Subjects at high risk for atherosclerosis with total cholesterol greater than 7.25 mmol/L (280 mg/dL) have a glycosylated hemoglobin (6.32 percent) that is in the range of well-controlled diabetics. Subjects with moderately elevated cholesterol have moderately elevated glycosylated hemoglobin (5.92 percent) compared with normocholesterolemic subjects (5.53 percent). These results support the hypothesis that elevated blood glucose that is associated with hypercholesterolemia is responsible for some of the atherogenesis associated with high cholesterol levels.
Urberg
M
M
Department of Family Medicine, School of Medicine, Wayne State University, Detroit, Michigan 48201.
Rajdev
K
K
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000209:etiology; D005260:Female; D005947:Glucose / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D002784:Cholesterol; D008076:Cholesterol, HDL; D005947:Glucose; D006442:Glycated Hemoglobin