title: Comparative study of sister-chromatid exchanges and chromosomal aberrations induced by airborne particulates from an urban and a highly industrialized location in human lymphocyte cultures.
abstract: Cytogenetic effects induced by extracts of airborne particulates in human lymphocyte cultures were studied with regard to local and seasonal variations. Samples of airborne particulates were collected from an urban and a highly industrialized area in March and October, respectively. All extracts of particulates induced a significant increase of sister-chromatid exchanges (SCE) in a dose-dependent manner. Referring to the induction of sister-chromatid exchanges, local and seasonal differences were observed. Samples from the industrialized area revealed the highest activities. In addition, SCE rates found for March samples were always higher than those for October for both locations. Furthermore, a remarkable, significant induction of chromosomal aberrations occurred with all samples from both locations and sampling periods. Aspects of health risk evaluation for exposed human populations are discussed with respect to the observed cytogenetic effects of airborne particulates in human lymphocyte cultures.
authors.affiliation: Medical Institute of Environmental Hygiene, University of Düsseldorf, F.R.G.
authors.forename: W
authors.initials: W
authors.lastname: Hadnagy
authors.forename: N H
authors.initials: NH
authors.lastname: Seemayer
authors.forename: R
authors.initials: R
authors.lastname: Tomingas
authors.forename: K
authors.initials: K
authors.lastname: Ivanfy
mesh_terms: D000393:Air Pollutants / Q000633:toxicity; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005860:Germany, West; D006801:Humans; D007221:Industry; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure*; D009153:Mutagens; D012621:Seasons; D012854:Sister Chromatid Exchange; D014505:Urban Population
chemical_list: D000393:Air Pollutants; D009153:Mutagens