[Mechanisms of aspirin intolerance].
Aspirin intolerance brings on cutaneous and/or respiratory reactions. The mechanisms are to be elucidated precisely, but are not IgE-mediated. 193 patients with nasal polyps are studied. With systematic aspirin oral challenge, 27% belong to the classical triad: asthma, polyps and aspirin sensitivity. Other drugs or chemicals intolerance are associated in 42%: alcohol, metabisulfites, benzoates, tartrazine, codeine... A link with the non-allergic eosinophilic rhinitis is suggested. A short review of several pathogenic hypothesis is discussed. Among a comparative study, the authors showed that the aspirin-intolerant patients' platelets have a quite normal arachidonic acid metabolism. The clue is probably towards an abnormal instability of cells membranes and excessive receptors sensitivity to leukotrienes.
Moneret-Vautrin
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DA
Wayoff
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Bonne
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D001095:Arachidonic Acids / Q000378:metabolism; D001241:Aspirin / Q000009:adverse effects*; D001982:Bronchial Diseases / Q000139:chemically induced; D055598:Chemical Phenomena; D002621:Chemistry; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000503:physiopathology*; D005609:Free Radicals; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D009298:Nasal Polyps / Q000139:chemically induced; D010038:Otorhinolaryngologic Diseases / Q000139:chemically induced; D010743:Phospholipids / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism
D001095:Arachidonic Acids; D005609:Free Radicals; D008563:Membrane Lipids; D010743:Phospholipids; D011453:Prostaglandins; D001241:Aspirin
Les mécanismes de l'intolérance à l'aspirine.