Pseudomonas exotoxin--immunotoxins.
Monoclonal antibodies can be coupled with PE to make very potent ITs. Two of these ITs (PE-HB21 and OVB-3-PE) have been shown to have antitumor activity in a nude mouse model of ovarian cancer. PE ITs are at least 10-fold more active than the corresponding RTA IT. Deletion analysis of the structural gene of PE has helped assign specific functions to different portions of the molecule. Current efforts are focused on making ITs with recombinant PE.
FitzGerald
D J
DJ
Willingham
M C
MC
Pastan
I
I
D036002:ADP Ribose Transferases; D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000912:Antibodies, Neoplasm / Q000008:administration & dosage; D001427:Bacterial Toxins; D003432:Cross-Linking Reagents; D004354:Drug Screening Assays, Antitumor; D004815:Epidermal Growth Factor; D005098:Exotoxins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005798:Genes, Bacterial; D006801:Humans; D000922:Immunotoxins / Q000627:therapeutic use; D051379:Mice; D008819:Mice, Nude; D010051:Ovarian Neoplasms / Q000188:drug therapy; D020652:Peptide Elongation Factor 2; D010445:Peptide Elongation Factors / Q000037:antagonists & inhibitors; D015202:Protein Engineering; D011550:Pseudomonas aeruginosa / Q000235:genetics; D012276:Ricin / Q000494:pharmacology; D014168:Transferrin; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A
D036002:ADP Ribose Transferases; D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D001427:Bacterial Toxins; D003432:Cross-Linking Reagents; D004815:Epidermal Growth Factor; D005098:Exotoxins; D000922:Immunotoxins; D020652:Peptide Elongation Factor 2; D010445:Peptide Elongation Factors; D012276:Ricin; D014168:Transferrin; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A