title: Adverse ocular reactions possibly associated with isotretinoin.
abstract: A total of 261 adverse ocular reactions occurred in 237 patients who received isotretinoin, a commonly used drug in the treatment of severe cystic acne. Blepharoconjunctivitis, subjective complaints of dry eyes, blurred vision, contact lens intolerance, and photodermatitis are reversible side effects. More serious ocular adverse reactions include papilledema, pseudotumor cerebri, and white or gray subepithelial corneal opacities; all of these are reversible if the drug is discontinued. Reported cases of decreased dark adaptation are under investigation. Isotretinoin is contraindicated in pregnancy because of the many reported congenital abnormalities after maternal use (including microphthalmos, orbital hypertelorism, and optic nerve hypoplasia).
authors.forename: F T
authors.initials: FT
authors.lastname: Fraunfelder
authors.forename: J M
authors.initials: JM
authors.lastname: LaBraico
authors.forename: S M
authors.initials: SM
authors.lastname: Meyer
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D002386:Cataract / Q000139:chemically induced; D003231:Conjunctivitis / Q000139:chemically induced; D003560:Cysts / Q000188:drug therapy; D005123:Eye / Q000187:drug effects*; D005128:Eye Diseases / Q000139:chemically induced; D005141:Eyelid Diseases / Q000139:chemically induced; D006801:Humans; D007249:Inflammation / Q000139:chemically induced; D015474:Isotretinoin; D010787:Photosensitivity Disorders / Q000139:chemically induced; D012871:Skin Diseases / Q000188:drug therapy; D014212:Tretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D014786:Vision Disorders / Q000139:chemically induced
chemical_list: D014212:Tretinoin; D015474:Isotretinoin