title: Lephetamine abuse and dependence: clinical effects and withdrawal syndrome.
abstract: Lephetamine (L-SPA) is a compound with central analgesic and anti-inflammatory action, recently reported to be abused in Italy. In this study, cases of L-SPA abuse were recorded. The survey included 15 patients who were assessed for effects caused by using L-SPA and induced by withdrawal. Moreover L-SPA was administered to 15 volunteers. L-SPA displayed effects partly similar to opiates and its withdrawal caused both subjective and objective symptoms. It is concluded that L-SPA exhibits abuse liability and dependence potential of a certain degree.
authors.forename: L
authors.initials: L
authors.lastname: Janiri
authors.forename: P
authors.initials: P
authors.lastname: Mannelli
authors.forename: C
authors.initials: C
authors.lastname: Pirrongelli
authors.forename: M
authors.initials: M
authors.lastname: Lo Monaco
authors.forename: E
authors.initials: E
authors.lastname: Tempesta
mesh_terms: D005260:Female; D008297:Male; D010627:Phenethylamines / Q000009:adverse effects; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D019966:Substance-Related Disorders / Q000209:etiology*
chemical_list: D010627:Phenethylamines; C011896:lephetamine