[Severe toxic hepatitis during flutamide (Eulexin) treatment].
A case of severe toxic hepatitis in a patient with metastatic prostatic cancer treated for three months with flutamide (Eulexin) combined with an LHRH analogue, goserelin (Zoladex) is described. The patient developed severe liver failure with jaundice, ascites and severe encephalopathy. The condition reversed after discontinuation of flutamide. Less severe, but otherwise similar, adverse reactions have been reported in the literature, and the importance of considering the drug as a potential hepatotoxin is stressed.
Møller
S
S
Iversen
P
P
D000813:Anilides / Q000009:adverse effects*; D001201:Ascites / Q000139:chemically induced; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D005485:Flutamide / Q000009:adverse effects*; D006501:Hepatic Encephalopathy / Q000139:chemically induced; D006801:Humans; D008875:Middle Aged
D000813:Anilides; D005485:Flutamide
Svaer toksisk hepatitis under flutamid-(Eulexin)-behandling.