[The complement system. Normal values and congenital deficiencies in the adult Mexican population].
Five hundred mexican mestizos, healthy blood donors were evaluated regarding the hemolytic activity of their serum, to assess the function of the complement (C) system. One of them was hypocomplementemic and his serum was unable to promote hemolysis by either classical or alternative pathway. It had normal protein concentrations of C3 and C4, as well as immunoreactive C1, C4, C5, C6, C7 and C8, and lytic factor D. Factor B was not recognizable. It is possible that a genetic deficiency linked to genes codifying for class III products of the major histocompatibility complex is responsible for our findings.
Becerra Posada
C
C
Reyes
P A
PA
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D003167:Complement Activation; D003175:Complement C2 / Q000172:deficiency / Q000235:genetics; D011415:Complement Factor B / Q000172:deficiency / Q000235:genetics; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D005787:Gene Frequency; D006461:Hemolysis; D006801:Humans; D008285:Major Histocompatibility Complex; D008297:Male; D008800:Mexico; D008875:Middle Aged; D012016:Reference Values
D003175:Complement C2; D003165:Complement System Proteins; D011415:Complement Factor B
El sistema del complemento. Valores normales y deficiencias congénitas en población adulta en México.