HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the helical region of the alpha 1 domain.
Genes encoding the serologically cross-reactive HLA-B51 and HLA-Bw52 molecules were isolated and the exons sequenced. HLA-B51 genes obtained from Caucasian and Oriental individuals were identical. HLA-Bw52 differs from HLA-B51 by four nucleotide substitutions in exon 2 encoding the alpha 1 domain. These comprise one isolated silent substitution in codon 23 and a cluster of three coding substitutions in codons 63 and 67. Amino acid substitutions of N----E at position 63 and F----S at position 67 are the only differences between HLA-B51 and HLA-Bw52 and these residues are postulated to form HLA-B51 specific epitopes. HLA-B51 could have been formed from HLA-Bw52 by the combination of a genetic exchange with HLA-B8 and a point mutation. Similarity of HLA-B51 and HLA-Bw52 with HLA-Bw58 suggest they also share a common ancestor.
Hayashi
H
H
Department of Cell Biology, Stanford University, CA 94305.
Ennis
P D
PD
Ariga
H
H
Salter
R D
RD
Parham
P
P
Kano
K
K
Takiguchi
M
M
D000595:Amino Acid Sequence; D000818:Animals; D001482:Base Composition; D001483:Base Sequence; D003001:Cloning, Molecular; D003429:Cross Reactions; D005805:Genes, MHC Class I; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D059949:HLA-B51 Antigen; D059950:HLA-B52 Antigen; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid
D015235:HLA-B Antigens; D059949:HLA-B51 Antigen; D059950:HLA-B52 Antigen