title: Tympanic membrane structure during a Staphylococcus aureus-induced middle ear infection. A study in the rat middle ear.
abstract: In response to a Staphylococcus aureus-induced middle ear infection the tympanic membrane showed infiltration of polymorphonuclear granulocytes, lymphocytes, and macrophages and increased areas covered by ciliary and secretory epithelium. These reactions, which were comparable to the cellular and mucociliary responses seen in the middle ear mucosa during infection, were restricted to the pars flaccida and to predominantly the annular and manubrial regions of the pars tensa. This showed that the greater part of the tympanic membrane, where the lamina propria is composed of collagenous bundles and only very thin layers of loose connective tissue, is hardly affected by or barely responds to the inflammatory stimulus.
authors.affiliation: Ear, Nose and Throat Department, University Hospital, Leiden, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Grote
authors.forename: D
authors.initials: D
authors.lastname: Bakker
authors.forename: S C
authors.initials: SC
authors.lastname: Hesseling
authors.forename: C A
authors.initials: CA
authors.lastname: van Blitterswijk
mesh_terms: D000818:Animals; D008297:Male; D008854:Microscopy, Electron; D010033:Otitis Media / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013203:Staphylococcal Infections / Q000473:pathology*; D014432:Tympanic Membrane / Q000648:ultrastructure*