Amelioration of the hypotensive effect of trypanocidal diamidines by use of heavy soluble salts.
The influence of a heavy soluble dicaprylate salt preparation of a new trypanocidal diamidine (DiaPBF) on systolic and diastolic blood pressure and heart rate of rats has been compared with the effects of the easily soluble DiaPBF-dihydrochloride (DiaPBF-diHCl). After the dicaprylate the drop of the systolic blood pressure was 50% smaller than after an equimolar doses of DiaPBF-diHCl.
Steinmann
U
U
Institute of Pharmacology and Toxicology, University of Erlangen-Nürnberg, FRG.
Fritsch
C
C
D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002210:Caprylates / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014344:Trypanocidal Agents / Q000494:pharmacology*
D000578:Amidines; D001572:Benzofurans; D002210:Caprylates; D014344:Trypanocidal Agents; C059317:2-(4-amidinophenyl)-5-benzofurancarboxamidine