title: Modeling of the homoeo domain suggests similar structure to repressors.
abstract: The sequences of the homoeo domain containing the three alpha-helices were modeled based on secondary structure prediction, sequence homologies and coordinates of known helix-turn-helix motif containing DNA-binding proteins. The model reveals very similar three dimensional structure to repressors and suggest binding to DNA with its helix 3.
authors.affiliation: VA Medical Center, Indiana University, Indianapolis 46202.
authors.forename: P A
authors.initials: PA
authors.lastname: Tsonis
authors.forename: V
authors.initials: V
authors.lastname: Carperos
authors.forename: T
authors.initials: T
authors.lastname: Siahaan
authors.forename: T
authors.initials: T
authors.lastname: Shiahaan
mesh_terms: D000595:Amino Acid Sequence; D003198:Computer Simulation; D004268:DNA-Binding Proteins / Q000648:ultrastructure*; D005801:Genes, Homeobox; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012097:Repressor Proteins; D013329:Structure-Activity Relationship
chemical_list: D004268:DNA-Binding Proteins; D012097:Repressor Proteins