[Secretion of type-E prostaglandin by tumor cells of different degrees of malignancy when in contact with effectors of natural resistance].
It was demonstrated that short-term contact of highly malignant tumour cells with NK-cells, neutrophils and macrophages induced rapid PGE secretion into the culture medium. PGE is detected in the culture fluids by the biological test based on inhibition of cytotoxic activity of NK-cells in standard cytotoxic tests. In the direct radioimmunoassay no PGE release was detected when low malignant tumour cells contact with effector cells of natural resistance system as well as after malignant tumour cell pretreatment with indomethacin. There was no increase in PGE secretion by the malignant tumour cells after their in vitro contact with red cells, normal hamster embryo cells and tumour cells of different origin.
Kliuchareva
T E
TE
Matveeva
V A
VA
Kashkina
L M
LM
Kushlinskiĭ
N E
NE
Bassalyk
L S
LS
D000818:Animals; D002450:Cell Communication; D002460:Cell Line; D006224:Cricetinae; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008647:Mesocricetus; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000276:immunology / Q000378:metabolism*; D009504:Neutrophils / Q000276:immunology*; D011458:Prostaglandins E / Q000032:analysis / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D011458:Prostaglandins E
Sekretsiia prostaglandina tipa E opukholevymi kletkami raznoĭ stepeni zlokachestvennosti pri ikh kontakte s éffektorami estestvennoĭ rezistentnosti.