title: An evaluation of the acute toxic properties of liquids derived from oil sands.
abstract: The acute toxicity of three materials derived from Athabasca Oil Sands--(1) bitumen plus naphtha, (2) untreated naphtha (0-250 degrees C) and (3) synthetic crude oil (0-500 degrees C)--was assessed in a battery of tests. In acute oral studies, all three test materials exhibited a low order of toxicity (LD50 greater than 5.0 g kg-1). The acute dermal LD50 was also low (greater than 3 g kg-1) for each test material. All three materials were judged to be 'slight' ocular irritants. Acute inhalation studies (6-h exposures at the maximum attainable concentrations) produced varied responses. Bitumen plus naphtha administered at a concentration of 1.46 mg l-1 did not cause mortality in exposed rats or mice. Lung discoloration was the only necropsy finding of note. Untreated naphtha administered at a concentration of 10.6 mg l-1 was lethal to essentially all of the mice; but only two rats died. Necropsy findings included elevated weights in the liver and kidneys of the exposed mice, elevated lung weights in male rats and elevated liver weights in female rats. Synthetic crude oil administered at a concentration of (4 mg l-1) was lethal to 5/10 mice, but none of the rats (0/10) died. Severe hair loss was noted in the surviving mice, and slight alopecia was also observed in rats. Both species exhibited elevated liver weight, and elevated lung weight was noted in female rats.
authors.affiliation: Exxon Biomedical Sciences, Inc., East Millstone, NJ 08873.
authors.forename: W A
authors.initials: WA
authors.lastname: Stubblefield
authors.forename: R H
authors.initials: RH
authors.lastname: McKee
authors.forename: R W
authors.initials: RW
authors.lastname: Kapp
authors.forename: J P
authors.initials: JP
authors.lastname: Hinz
mesh_terms: D000279:Administration, Cutaneous; D000280:Administration, Inhalation; D000284:Administration, Oral; D000473:Alkanes / Q000633:toxicity*; D000505:Alopecia / Q000139:chemically induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003877:Dermatitis, Contact / Q000209:etiology*; D005123:Eye / Q000187:drug effects*; D005260:Female; D006838:Hydrocarbons / Q000633:toxicity*; D007509:Irritants; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010578:Petroleum / Q000633:toxicity*; D011817:Rabbits; D051381:Rats
chemical_list: D000473:Alkanes; D006838:Hydrocarbons; D007509:Irritants; D010578:Petroleum; C006647:asphalt; C004544:naphtha