title: Adjuvant treatment of node-negative breast cancer.
abstract: About half of all breast cancer patients do not have axillary nodal involvement at the time of diagnosis, and this fraction will become even larger as more women participate in screening mammography programs. Recently completed trails of limited surgery have changed the primary management of node-negative disease for many women. Now, early results from a number of carefully controlled clinical trails suggest ways in which the approach to adjuvant treatment of this disease can be improved.
authors.forename: D E
authors.initials: DE
authors.lastname: Merkel
authors.forename: C K
authors.initials: CK
authors.lastname: Osborne
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D011379:Prognosis; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D013629:Tamoxifen