Neural substrates for long-term habituation of the acoustic startle reflex in rats: a 2-deoxyglucose study.
Autoradiography with [14C]2-deoxyglucose was used to examine the functional activity of the rat brain during long- and short-term habituation of the acoustic startle reflex. Long-term habituated rats, when compared to short-term rats, showed an enhanced metabolic activation of the auditory system, with the exclusion of thalamocortical levels. Regional metabolic increases were also located within the cerebellum and its major input-output structures. In contrast, the midbrain reticular formation and its ascending thalamocortical activating system showed a widespread metabolic suppression. The findings provide the first map of structures in a mammalian brain with learning-related metabolic alterations dependent on long-term habituation.
Gonzalez-Lima
F
F
Department of Anatomy, College of Medicine, Texas A&M University, College Station 77843.
Finkenstädt
T
T
Ewert
J P
JP
D000161:Acoustic Stimulation; D000818:Animals; D001306:Auditory Pathways / Q000378:metabolism / Q000502:physiology*; D001345:Autoradiography; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D002531:Cerebellum / Q000378:metabolism / Q000502:physiology; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D006185:Habituation, Psychophysiologic; D008297:Male; D051381:Rats; D013216:Reflex, Startle / Q000502:physiology*; D013116:Spinal Cord / Q000378:metabolism / Q000502:physiology*; D013997:Time Factors
D003837:Deoxy Sugars; D003847:Deoxyglucose