Effect of inhaled procaterol hydrochloride in children with bronchial asthma, with particular reference to duration of effect.
This double-blind crossover trial evaluated the prolonged clinical effect of procaterol inhaled in a dose of 10 micrograms by nine asthmatic children with mild and stable respiratory disturbance. To compare procaterol with the placebo administered with a pressurized metered-dose inhaler 48 hr before or after procaterol, FVC, FEV1, V50, and V25 were followed up for 10 hr. FVC did not indicate a significant difference between the two treatments, while FEV1, V50, and V25 showed significantly greater changes after procaterol administration. The duration of action of procaterol in terms of FEV1, V50, and V25 was 6, 10, and 4 hr, respectively.
Mitsuhashi
M
M
Kimura
T
T
Tateno
K
K
Morikawa
A
A
Kuroume
T
T
D000293:Adolescent; D000336:Aerosols; D001249:Asthma / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004983:Ethanolamines / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D017265:Procaterol; D011674:Pulse / Q000187:drug effects; D012129:Respiratory Function Tests; D014797:Vital Capacity
D000336:Aerosols; D004983:Ethanolamines; D010919:Placebos; D017265:Procaterol