Beta-blockers, lipoproteins and non-insulin dependent diabetes.
In a study on 138 hypertensive non-insulin dependent diabetic subjects, factors influencing lipoproteins were assessed. Multiple regression analyses were carried out in order to assess the influence of beta-blocker antihypertensive therapy while making allowances for other confounding variables. In males, but not in females, on a beta-blocker for hypertension, total high density lipoprotein- (HDL-) and HDL-subfraction cholesterol were significantly lower while the serum triglyceride was increased, though not significantly. In male non-insulin dependent diabetics, regimens containing a beta-blocker may worsen an already abnormal lipoprotein profile and antihypertensive agents other than beta-blocking agents should be used if possible.
Feher
M D
MD
Department of Clinical Pharmacology, St. Mary's Hospital, London, UK.
Rains
S G
SG
Richmond
W
W
Torrens
D
D
Wilson
G
G
Wadsworth
J
J
Sever
P S
PS
Elkeles
R S
RS
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis
D000319:Adrenergic beta-Antagonists; D008076:Cholesterol, HDL; D008074:Lipoproteins; D008075:Lipoproteins, HDL