title: Modelling basic features of specificity in DNA-aureolic acid-derived antibiotic interactions.
abstract: The nonintercalative groove binding of a simplified model of olivomycin, to sequences d(CGCGCGC)2, d(TATATAT)2, and d(CICICIC)2 is investigated. A significant preference is displayed for the minor groove of the d(CG) sequence. This is due predominantly to the formation of H-bonds between the hydroxyl groups on the aglycone of the drug and the 2-amino group of the central guanine of the oligonucleotide.
authors.affiliation: Institut de Biologie Physico-Chimique, Laboratoire de Biochimie Théorique associé au CNRS, Paris, France.
authors.forename: K X
authors.initials: KX
authors.lastname: Chen
authors.forename: N
authors.initials: N
authors.lastname: Gresh
authors.forename: X
authors.initials: X
authors.lastname: Hui
authors.forename: B
authors.initials: B
authors.lastname: Pullman
authors.forename: K
authors.initials: K
authors.lastname: Zakrzewska
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000378:metabolism*; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D009848:Olivomycins / Q000378:metabolism*; D013816:Thermodynamics
chemical_list: D009848:Olivomycins; D004247:DNA