Effect of inhibitors of gamma-glutamyl transpeptidase on the uptake of glutamate and aspartate into cultured astroglial cells from the glycogen body and cerebral hemispheres of the embryonic chick.
Astroglial-like cells from the glycogen body and astroglia from the cerebral hemispheres of chick embryos cultured 6 days in vitro exhibit comparable values of L-glutamate and L-aspartate uptake. The uptake is significantly reduced by inhibitors of gamma-glutamyl transpeptidase.
Jankásková
B
B
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
Stastný
F
F
Lisý
V
V
Pearce
B
B
Murphy
S
S
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D001881:Borates / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D002478:Cells, Cultured; D002642:Chick Embryo; D003980:Diazooxonorleucine / Q000494:pharmacology; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D007608:Kainic Acid / Q000494:pharmacology; D012694:Serine / Q000494:pharmacology; D013116:Spinal Cord / Q000378:metabolism*; D005723:gamma-Glutamyltransferase / Q000037:antagonists & inhibitors*
D001881:Borates; D005971:Glutamates; D003980:Diazooxonorleucine; D001224:Aspartic Acid; D018698:Glutamic Acid; D012694:Serine; D005723:gamma-Glutamyltransferase; D007608:Kainic Acid