Changes in activities of some ammonia-metabolizing enzymes in the rat liver and the brain after chronic ethanol administration.
The changes in the activities of ammonia-metabolizing enzymes in liver and brain after ethanol intoxication has been investigated in rats. After administration of ethanol 30% (w/v) 6g kg-1 for 4 weeks we found an increase in liver glutamate dehydrogenase and glutaminase activity. In brain tissue the glutaminase activity was significantly higher and glutamate dehydrogenase was significantly lower. Glutamine synthetase activity in liver and brain was practically unchanged. The reasons for these changes in the activities of some ammonia-metabolizing enzymes in liver and brain after ethanol ingestion have been discussed.
Farbiszewski
R
R
Department of Inorganic and Analytical Chemistry Medical Academy, Białystok, Poland.
Hołownia
A
A
Chwiećko
M
M
D000641:Ammonia / Q000378:metabolism*; D000818:Animals; D001066:Appetite / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D000431:Ethanol / Q000097:blood / Q000633:toxicity*; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism; D005972:Glutaminase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D000431:Ethanol; D000641:Ammonia; D005969:Glutamate Dehydrogenase; D005972:Glutaminase; D005974:Glutamate-Ammonia Ligase