title: [Clinical evaluation of drug interactions of cyclosporin].
abstract: Cyclosporin is a nephrotoxic immunosuppressant metabolized in the liver and requiring drug monitoring. Numerous pharmacokinetic and pharmacodynamic drug interactions have occurred with this compound. Some of them are well substantiated while others are merely suspected. The major interactions must definitely be prevented of corrected, whereas the others need no more than careful drug monitoring.
authors.affiliation: Service de Pharmacologie clinique, Hôpital Broussais, Paris.
authors.forename: E M
authors.initials: EM
authors.lastname: Billaud
authors.forename: C
authors.initials: C
authors.lastname: Kreft-Jais
authors.forename: F
authors.initials: F
authors.lastname: De la Tour du Pin
authors.forename: J M
authors.initials: JM
authors.lastname: Alexandre
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D003524:Cyclosporins / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008775:Methylprednisolone / Q000494:pharmacology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002121:Calcium Channel Blockers; D003524:Cyclosporins; D006635:Histamine H2 Antagonists; D008775:Methylprednisolone
vernacular_title: Evaluation clinique des interactions médicamenteuses de la ciclosporine.