title: Pharmacokinetics of theophylline before and after nephrectomy in dogs.
abstract: The role of the kidneys in the elimination of theophylline was directly assessed using nephrectomized dogs. Data was analyzed by two different pharmacokinetic approaches. Analysis indicated that a given dosage regimen produced significantly different serum concentrations before and after nephrectomy. Model independent pharmacokinetic analysis failed to show a significant difference in parameters. A model dependent approach, using a nonlinear regression analysis employing a linear two-compartment model, demonstrated that the differences observed could be accounted for by a change in the first order elimination kinetics.
authors.affiliation: Indiana University School of Medicine, Indianapolis.
authors.forename: R E
authors.initials: RE
authors.lastname: Brashear
authors.forename: P
authors.initials: P
authors.lastname: Veng-Pedersen
authors.forename: M D
authors.initials: MD
authors.lastname: Karol
mesh_terms: D000818:Animals; D004285:Dogs; D007668:Kidney / Q000378:metabolism*; D008954:Models, Biological; D009392:Nephrectomy; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D013806:Theophylline