Reserpine, para-chlorophenylalanine and fenfluramine antagonise cisplatin-induced emesis in the ferret.
The involvement of 5-hydroxytryptamine (5-HT) with cisplatin-induced emesis in the ferret was investigated using reserpine, para-chlorophenylalanine and fenfluramine. Pretreatment with reserpine (5 mg/kg, 24 hr), fenfluramine (5 mg/kg, 4 days) or para-chlorophenylalanine (100 or 400 mg/kg, 4 days) antagonised cisplatin-induced emesis. All treatments reduced the levels of 5-HT in the area postrema and at other cerebral sites, but whilst this action was relatively selective for small doses of para-chlorophenylalanine [only modest effects on noradrenaline (NA) and no change in the content of dopamine (DA) in the area postrema], other treatments reduced levels of dopamine and noradrenaline. Data are discussed in terms of an involvement of 5-HT/catecholamines in the area postrema with the mediation of emesis induced by cisplatin.
Barnes
J M
JM
Postgraduate School of Studies in Pharmacology, University of Bradford, U.K.
Barnes
N M
NM
Costall
B
B
Naylor
R J
RJ
Tattersall
F D
FD
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002335:Carnivora / Q000502:physiology*; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism; D002945:Cisplatin / Q000037:antagonists & inhibitors*; D010134:Fenclonine / Q000494:pharmacology*; D005277:Fenfluramine / Q000494:pharmacology*; D005289:Ferrets / Q000502:physiology*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D012110:Reserpine / Q000494:pharmacology*; D014839:Vomiting / Q000139:chemically induced* / Q000517:prevention & control
D015306:Biogenic Monoamines; D018377:Neurotransmitter Agents; D005277:Fenfluramine; D012110:Reserpine; D002945:Cisplatin; D010134:Fenclonine