Study on dermal toxicity and urinary metabolites of the new insect repellent N,N-diethylphenylacetamide in rabbits.
Dermal toxicity of the new multi-insect repellent N,N-diethylphenylacetamide (DEPA) was studied in female rabbits. LD50 of DEPA was estimated to be 3505 mg/kg b.w. On daily topical application for 21 d at a dose of 50 mg/kg b.w., dermal irritancy score and blood chemistry changes indicated that the compound is non-irritant and non-toxic. N-Ethylphenylacetamide and conjugated phenylacetic acid were identified as the urinary metabolites of DEPA by gas-liquid chromatography.
Rao
S S
SS
Biochemistry Division, Defence Research and Development Establishment, Gwalior, India.
Agarwal
M K
MK
Rao
K M
KM
Swamy
R V
RV
D000081:Acetamides / Q000008:administration & dosage / Q000633:toxicity* / Q000652:urine; D000083:Acetanilides; D000279:Administration, Cutaneous; D000818:Animals; D001774:Blood Chemical Analysis; D002849:Chromatography, Gas; D005260:Female; D007302:Insect Repellents / Q000633:toxicity*; D007928:Lethal Dose 50; D010648:Phenylacetates / Q000652:urine; D011817:Rabbits; D012869:Skin Absorption
D000081:Acetamides; D000083:Acetanilides; D007302:Insect Repellents; D010648:Phenylacetates; C044250:N,N-diethylphenylacetamide