Effect of cortical kindling on [3H]D-aspartate uptake and glutamate metabolism in rats.
The effects of cortical kindling in rats on [3H]D-aspartate uptake and on glutaminase and glutamine synthetase activities has been studied. The high affinity uptake of [3H]D-aspartate in control cortical tissue (Km approximately 2 microM) was undetectable in the kindled tissue, whilst the enzyme activities were unchanged. A loss of the high-affinity uptake sites for excitatory amino acids may be a contributing factor to the kindling phenomenon.
Leach
M J
MJ
Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent, U.K.
O'Donnell
R A
RA
Collins
K J
KJ
Marden
C M
CM
Miller
A A
AA
D000818:Animals; D001224:Aspartic Acid / Q000493:pharmacokinetics*; D002540:Cerebral Cortex / Q000378:metabolism*; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D005972:Glutaminase / Q000378:metabolism*; D066298:In Vitro Techniques; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid; D005972:Glutaminase; D005974:Glutamate-Ammonia Ligase