title: Prognostic value of serum phospholipase A in acute pancreatitis.
abstract: Serum from 48 patients with acute pancreatitis (21 with interstitial-edematous and 27 with necrotizing pancreatitis) was monitored for immunoreactive (IR) phospholipase A2 (PLA2) protein concentration and PLA catalytic activity. In both groups within 48 h after start of acute pancreatitis an up to tenfold increase of IR-PLA2 was demonstrable. Determination of IR-PLA2 revealed no differences between the groups. In contrast, determination of PLA catalytic activity allowed us to differentiate between patients with interstitial-edematous and necrotizing pancreatitis.
authors.affiliation: Department of Surgery, University of Ulm, Federal Republic of Germany.
authors.forename: M
authors.initials: M
authors.lastname: Büchler
authors.forename: P
authors.initials: P
authors.lastname: Malfertheiner
authors.forename: H
authors.initials: H
authors.lastname: Schädlich
authors.forename: T
authors.initials: T
authors.lastname: Nevalainen
authors.forename: T
authors.initials: T
authors.lastname: Mavromatis
authors.forename: H G
authors.initials: HG
authors.lastname: Beger
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015200:Fluoroimmunoassay; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000175:diagnosis* / Q000201:enzymology; D010740:Phospholipases / Q000097:blood*; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D011379:Prognosis
chemical_list: D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2