Cerebellar atrophy following acute intoxication with phenytoin.
A patient developed marked cerebellar atrophy after a single suicidal intoxication with 7 grams phenytoin. The clinical signs of cerebellar dysfunction subsided very slowly and incompletely within 18 months. We documented the cerebellar atrophy by CTs 4 weeks and 1 year after the intoxication, and we suggest that a single severe acute intoxication with phenytoin may directly cause cerebellar degeneration.
Masur
H
H
Department of Neurology, University of Münster, FRG.
Elger
C E
CE
Ludolph
A C
AC
Galanski
M
M
D000328:Adult; D001284:Atrophy; D002526:Cerebellar Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D002531:Cerebellum / Q000473:pathology; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000506:poisoning*; D014057:Tomography, X-Ray Computed
D010672:Phenytoin