title: Fetal treatment for thyrotoxicosis in non-thyrotoxic pregnant women.
abstract: Euthyroid or even hypothyroid pregnant women without antithyroid medication but with a history of treatment for thyrotoxicosis, almost always a subtotal strumectomy, may still produce thyroid-stimulating immunoglobulins. This can induce fetal and neonatal thyrotoxicosis. Without treatment this results in a high fetal and neonatal mortality and morbidity. Fetal treatment by administering antithyroid drugs during pregnancy improves this prognosis remarkably. A case is described, the literature is reviewed and guidelines for diagnosis and treatment are presented.
authors.affiliation: Department Obstetrics/Gynecology, University Hospital, Utrecht, The Netherlands.
authors.forename: H W
authors.initials: HW
authors.lastname: Bruinse
authors.forename: C
authors.initials: C
authors.lastname: Vermeulen-Meiners
authors.forename: J M
authors.initials: JM
authors.lastname: Wit
mesh_terms: D000328:Adult; D005260:Female; D005315:Fetal Diseases / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D018828:Immunoglobulins, Thyroid-Stimulating; D011247:Pregnancy / Q000276:immunology*; D011441:Propylthiouracil / Q000627:therapeutic use*; D013971:Thyrotoxicosis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D018828:Immunoglobulins, Thyroid-Stimulating; D011441:Propylthiouracil