Suppressor T cell changes in active multiple sclerosis: analysis with three different monoclonal antibodies.
This study demonstrates a significant reduction in the number of both total T cells and suppressor T cells identified by monoclonal antibodies in multiple sclerosis patients in acute relapse but not in those in remission. The reduction in the number of suppressor T cells was shown by all three monoclonal antibodies used but was most clearly demonstrated using Leu 2a rather than either OKT 8 or OKT 5. These findings suggest that the choice of monoclonal antibody used in a study of suppressor T cell numbers will influence the results and may help explain the lack of agreement in previous studies.
Thompson
A J
AJ
Brazil
J
J
Martin
E A
EA
Hutchinson
M
M
Whelan
C A
CA
Feighery
C
C
D000911:Antibodies, Monoclonal; D006801:Humans; D007958:Leukocyte Count; D009103:Multiple Sclerosis / Q000097:blood*; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory
D000911:Antibodies, Monoclonal