title: Possible in vivo modulation of Leu 2a expression on suppressor T cells in active multiple sclerosis.
abstract: Reduced numbers of suppressor T lymphocytes were identified by monoclonal antibodies in the peripheral blood of patients with multiple sclerosis (MS) in acute relapse. In vitro culture of cells from these patients resulted in a significant increase in the number of cells identified with the suppressor T cell marker Leu 2a but not OKT 8. The expression of other T cell antigens (Leu 4 and Leu 3a) remained unchanged. This change in Leu 2a expression did not occur when cells from healthy controls were similarly treated.
authors.forename: A J
authors.initials: AJ
authors.lastname: Thompson
authors.forename: J
authors.initials: J
authors.lastname: Brazil
authors.forename: C A
authors.initials: CA
authors.lastname: Whelan
authors.forename: C
authors.initials: C
authors.lastname: Feighery
mesh_terms: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000032:analysis*; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface