title: [Progressive multifocal leukoencephalopathy in Wegener's granulomatosis in relation to therapy with cyclosporin A].
abstract: A female patient with Wegener's granulomatosis developed severe bone marrow depression after two years treatment with cyclophosphamide. Corticosteroids alone could not sufficiently suppress disease activity, therefore additive therapy with Cyclosporin A was started. Four weeks later the patient developed a central nervous system disorder with affective disturbances and progressive somnolence. However, inspite of intensive diagnostic procedures, no definite diagnosis could be established. After another two months she died. Post-mortem-examination showed progressive multifocal leukoencephalopathy. An association between immunosuppressive therapy and reactivation of JC-Virus is suggested.
authors.affiliation: Medizinische Klinik Innenstadt, Universität München.
authors.forename: J
authors.initials: J
authors.lastname: Ettinger
authors.forename: W
authors.initials: W
authors.lastname: Feiden
authors.forename: G
authors.initials: G
authors.lastname: Hübner
authors.forename: M
authors.initials: M
authors.lastname: Schreiner
mesh_terms: D001921:Brain / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged
chemical_list: D003524:Cyclosporins; D003520:Cyclophosphamide
vernacular_title: Progressive multifokale Leukoenzephalopathie bei Wegener'scher Granulomatose unter Therapie mit Cyclosporin A.