Gluco- and mineralocorticoids may regulate the natriuretic effect and the synthesis and release of atrial natriuretic factor by the rat atria in vivo.
Adrenalectomy abolished the acute natriuretic effect of ANF which was partially restored to about 50% by combined therapy with gluco- and mineralocorticoids. It is suggested that the lack of effect of ANF may be due to a decreased renal vascular reactivity to the peptide in adrenalectomized animals. Simultaneous administration of Dexamethasone and Deoxycorticosterone acetate to adrenalectomized rats produced a marked increase in immunoreactive ANF in atrial tissue and plasma. The administration of NaCl to these animals produced a relatively lower concentration of atrial ANF and a further increase in plasma ANF. Our results suggest that glucocorticoids may regulate synthesis and release of ANF by the atria and mineralocorticoids may have a permissive role. Furthermore, the presence of steroids is necessary for the NaCl-stimulated ANF release.
Garcia
R
R
Debinski
W
W
Gutkowska
J
J
Kuchel
O
O
Thibault
G
G
Genest
J
J
Cantin
M
M
D000315:Adrenalectomy; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000494:pharmacology / Q000502:physiology*; D003900:Desoxycorticosterone / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology / Q000502:physiology*; D006325:Heart Atria / Q000187:drug effects / Q000378:metabolism; D008901:Mineralocorticoids / Q000494:pharmacology / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism*; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology
D005938:Glucocorticoids; D008901:Mineralocorticoids; C472610:atrial natriuretic peptide, rat; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D003907:Dexamethasone; D009320:Atrial Natriuretic Factor