title: Does pretreatment with cimetidine and ranitidine affect the disposition of bupivacaine?
abstract: Thirty patients who chose extradural analgesia for elective Caesarean section were pretreated, by random selection, with cimetidine 400 mg, ranitidine 150 mg or no H2-blocker. Following the administration of 0.5% bupivacaine, no significant difference was found between peak plasma bupivacaine concentrations or area under the plasma bupivacaine concentration-time curve (AUC) in these three groups. This study shows that a single dose of cimetidine or ranitidine does not affect significantly the disposition of bupivacaine in the obstetric patient.
authors.affiliation: Department of Anaesthetics, Queen's University of Belfast.
authors.forename: R J
authors.initials: RJ
authors.lastname: Flynn
authors.forename: J
authors.initials: J
authors.lastname: Moore
authors.forename: P S
authors.initials: PS
authors.lastname: Collier
authors.forename: E
authors.initials: E
authors.lastname: McClean
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D002045:Bupivacaine / Q000493:pharmacokinetics*; D002585:Cesarean Section; D002927:Cimetidine / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011015:Pneumonia, Aspiration / Q000517:prevention & control; D011247:Pregnancy; D011292:Premedication; D011899:Ranitidine / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D002927:Cimetidine; D011899:Ranitidine; D002045:Bupivacaine