title: Is subradical surgical treatment for carcinoma of the cervix uteri stage IB logical?
abstract: Twenty-eight patients with squamous carcinoma of the cervix FIGO stage Ib were treated with three courses of neoadjuvant chemotherapy with a VBP modified scheme. Clinical responses showed that the percentage of complete and moderate responses exceeds 95% of the cases. Clinical response was also related to tumor bulk measurement by ultrasound scanning. Twenty-three of the patients were then subjected to the Wertheim-Meigs operation. Pathological findings of surgical specimens showed absence of residual lesion in 6 patients (26.1%) and carcinoma smaller than 0.5 cm in 5 patients (21.7%). Tumor response to neoadjuvant chemotherapy was excellent in NG3, MG3 tumors when lymphoplasmomonocytic infiltration was present. In accord with this result a new protocol was developed.
authors.forename: J
authors.initials: J
authors.lastname: Sardi
authors.forename: C
authors.initials: C
authors.lastname: Sananes
authors.forename: A
authors.initials: A
authors.lastname: Giaroli
authors.forename: N
authors.initials: N
authors.lastname: Gomez Rueda
authors.forename: G
authors.initials: G
authors.lastname: Di Paola
authors.forename: S
authors.initials: S
authors.lastname: Vighi
authors.forename: A
authors.initials: A
authors.lastname: Cachau
authors.forename: S
authors.initials: S
authors.lastname: Burlando
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008722:Methods; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*