title: The analysis of systolic and diastolic time intervals: a more sensitive non-invasive method in the assessment of left ventricular dysfunction in the patients with essential hypertension.
abstract: Time indices and volumetric parameters were investigated in patients with essential hypertension subdivided into three groups according to the WHO stage classification. The ratio of ejection time (ET) and pre-ejection period (PEP), ET/PEP remained within normal range in WHO-I but decreased significantly in WHO-II and reached extremely low values in WHO-III. ET did not change in WHO-I and WHO-II but became significantly reduced in WHO-III. Prolongation of PEP in WHO-II and WHO-III increased with progression of hypertensive stage. Isovolumic relaxation time (IRT) showed the same pattern as the prolongation of PEP; positive correlation between PEP and IRT was observed (r=0.55). On the other hand, significant changes of volumetric parameters were only observed in WHO-III. These results indicated that the time indices were a more sensitive parameter than the volumetric ones in the assessment of left ventricular dysfunction in the patients with essential hypertension.
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: Y
authors.initials: Y
authors.lastname: Shigematsu
authors.forename: Y
authors.initials: Y
authors.lastname: Kazatani
authors.forename: K
authors.initials: K
authors.lastname: Nishitani
authors.forename: K
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: F
authors.initials: F
authors.lastname: Daimon
authors.forename: T
authors.initials: T
authors.lastname: Ochi
authors.forename: T
authors.initials: T
authors.lastname: Kokubu
mesh_terms: D000328:Adult; D006332:Cardiomegaly / Q000503:physiopathology; D003971:Diastole; D004452:Echocardiography; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008875:Middle Aged; D009200:Myocardial Contraction; D013599:Systole