Structure of tumour necrosis factor.
Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an antiparallel beta-sandwich. Individual subunits from the trimer by a novel edge-to-face packing of beta-sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable similarity to the 'jelly-roll' structural motif characteristic of viral coat proteins.
Jones
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Laboratory of Molecular Biophysics, Oxford, UK.
Stuart
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Walker
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NP
D015394:Molecular Structure; D011487:Protein Conformation; D014409:Tumor Necrosis Factor-alpha
D014409:Tumor Necrosis Factor-alpha