Sensitivity of Burkitt lymphoma Daudi cells to inactive influenza virus.
Interaction of UV-inactivated influenza A/X47 virus at high multiplicity caused a rapid inhibition in cellular protein and DNA synthesis, thus arresting Burkitt-lymphoma-derived Daudi cell multiplication, and eventually killing the cells. The mechanism of the cytolytic effect is presumably, linked to the increase in cell membrane permeability indicated by elevation in 51Cr release. This might be the consequence of the mass adsorption and/or penetration of viral particles.
Shlomi
Y
Y
Department of Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Zakay-Rones
Z
Z
D002051:Burkitt Lymphoma / Q000473:pathology*; D002460:Cell Line; D002470:Cell Survival; D004273:DNA, Neoplasm / Q000096:biosynthesis; D066298:In Vitro Techniques; D009980:Influenza A virus / Q000528:radiation effects; D009363:Neoplasm Proteins / Q000096:biosynthesis; D014466:Ultraviolet Rays
D004273:DNA, Neoplasm; D009363:Neoplasm Proteins