Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine.
In cultured rat neocortex, uptake of [3H]serotonin (5-HT) and the SPECT radiopharmaceutical N-isopropyl-p-[123I]iodoamphetamine (IMP) was demonstrated after 4 and 14 days in vitro. Both imipramine and cold IMP inhibited [3H]5-HT uptake. Uptake of [123I]IMP was inhibited by imipramine but not by cold 5-HT. The similarity in the behaviors of IMP and imipramine indicates that uptake of IMP might be related to a serotonergic uptake system in a way that is similar to that in which imipramine is related to such a system.
de Jong
B M
BM
Netherlands Institute for Brain Research, Amsterdam.
Feenstra
M G
MG
Ruijter
J M
JM
van Royen
E A
EA
D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D007099:Imipramine / Q000494:pharmacology*; D007457:Iodine Radioisotopes; D020367:Iofetamine; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology
D000662:Amphetamines; D007457:Iodine Radioisotopes; D012702:Serotonin Antagonists; D012701:Serotonin; D020367:Iofetamine; D007099:Imipramine