Baboon-to-human cardiac xenotransplantation in a neonate.
This report details the first case of cardiac xenotransplantation in a neonate. The recipient, a victim of hypoplastic left heart syndrome (HLHS), survived 20 days. Autopsy findings are documented. The cardiac graft showed only traces of cell-mediated rejection. Graft failure appears to have resulted from a progressive, potentially avoidable humoral response, unmodified by immunosuppression. Cardiac allotransplantation and selective baboon-to-human xenotransplantation deserve further exploration as investigational therapy for neonatal HLHS.
Bailey
L L
LL
Nehlsen-Cannarella
S L
SL
Concepcion
W
W
Jolley
W B
WB
D000818:Animals; D001344:Autopsy; D001788:Blood Grouping and Crossmatching; D005260:Female; D006084:Graft Rejection; D006330:Heart Defects, Congenital / Q000601:surgery*; D016027:Heart Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D007231:Infant, Newborn; D007959:Lymphocyte Culture Test, Mixed; D009206:Myocardium / Q000473:pathology; D010215:Papio / Q000276:immunology; D033282:Parental Consent; D011184:Postoperative Period; D014183:Transplantation, Heterologous