title: Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers.
abstract: Single-dose oral administration of 100 mg caffeine increased the resting metabolic rate of both lean and postobese human volunteers by 3-4% (p less than 0.02) over 150 min and improved the defective diet-induced thermogenesis observed in the postobese subjects. Measurements of energy expenditure (EE) in a room respirometer indicate that repeated caffeine administration (100 mg) at 2-h intervals over a 12-h day period increased the EE of both subject groups by 8-11% (p less than 0.01) during that period but had no influence on the subsequent 12-h night EE. The net effect was a significant increase (p less than 0.02) in daily EE of 150 kcal in the lean volunteers and 79 kcal in the postobese subjects. Caffeine at commonly consumed doses can have a significant influence on energy balance and may promote thermogenesis in the treatment of obesity.
authors.affiliation: Department of Nutrition, King's College, University of London, UK.
authors.forename: A G
authors.initials: AG
authors.lastname: Dulloo
authors.forename: C A
authors.initials: CA
authors.lastname: Geissler
authors.forename: T
authors.initials: T
authors.lastname: Horton
authors.forename: A
authors.initials: A
authors.lastname: Collins
authors.forename: D S
authors.initials: DS
authors.lastname: Miller
mesh_terms: D000328:Adult; D001481:Basal Metabolism / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects*; D002110:Caffeine / Q000494:pharmacology*; D002149:Energy Intake; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D013997:Time Factors
chemical_list: D002110:Caffeine