title: Neuropeptide Y-immunoreactive neurons receive synaptic inputs from dopaminergic axon terminals in the rat neostriatum.
abstract: Double immunocytochemistry using peroxidase-antiperoxidase and protein A-gold was performed to determine whether neuropeptide Y (NPY) immunoreactive neurons receive synaptic inputs from catecholaminergic axon terminals in the rat neostriatum. Tyrosine hydroxylase-immunoreactive axons were found to be in synaptic contact with the somas and proximal dendrites of NPY-immunoreactive neostriatal neurons. These latter neurons were medium-sized and had indented nuclei, and thus were thought to be medium aspiny interneurons. Thus nigrostriatal dopaminergic neurons may monosynaptically influence striatal NPY neurons.
authors.affiliation: Department of Anatomy II, Osaka University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: S
authors.initials: S
authors.lastname: Inagaki
authors.forename: S
authors.initials: S
authors.lastname: Kito
authors.forename: S
authors.initials: S
authors.lastname: Shimada
authors.forename: T
authors.initials: T
authors.lastname: Okayama
authors.forename: H
authors.initials: H
authors.lastname: Hatanaka
authors.forename: G
authors.initials: G
authors.lastname: Pelletier
authors.forename: H
authors.initials: H
authors.lastname: Takagi
authors.forename: M
authors.initials: M
authors.lastname: Tohyama
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D003342:Corpus Striatum / Q000166:cytology / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D007124:Immunoenzyme Techniques; D008297:Male; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009478:Neuropeptide Y / Q000032:analysis* / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000166:cytology / Q000502:physiology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D009478:Neuropeptide Y; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine