title: Neurologic findings in men with isolated hypogonadotropic hypogonadism.
abstract: We studied the neurologic abnormalities in 41 men with isolated hypogonadotropic hypogonadism. Findings included anosmia, hyposmia, mirror movements, ocular motor abnormalities, cerebellar dysfunction, and pes cavus foot deformity. One-third of the subjects had a family history of delayed sexual maturation. Patients with a family history of delayed sexual maturation had a significantly higher incidence of olfactory dysfunction, mirror movements, and pes cavus foot deformity. Our data suggest that isolated hypogonadotropic hypogonadism and its accompanying neurologic abnormalities may arise from a genetically linked developmental abnormality of CNS structures.
authors.affiliation: Neurology Service, Veterans Administration Medical Center, Washington, DC.
authors.forename: J D
authors.initials: JD
authors.lastname: Schwankhaus
authors.forename: J
authors.initials: J
authors.lastname: Currie
authors.forename: M J
authors.initials: MJ
authors.lastname: Jaffe
authors.forename: S R
authors.initials: SR
authors.lastname: Rose
authors.forename: R J
authors.initials: RJ
authors.lastname: Sherins
mesh_terms: D000328:Adult; D002531:Cerebellum / Q000503:physiopathology; D015331:Cohort Studies; D006062:Gonadotropins / Q000172:deficiency*; D006801:Humans; D007006:Hypogonadism / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009420:Nervous System / Q000503:physiopathology*; D009833:Olfactory Pathways / Q000503:physiopathology; D012677:Sensation / Q000502:physiology; D014795:Visual Pathways / Q000503:physiopathology
chemical_list: D006062:Gonadotropins