title: ins(6;1) in a patient with congenital leukemia.
abstract: Q- and C-banded karyotypes of leukemic cells of a patient with congenital acute lymphoblastic leukemia showed the karyotype: 46,XX,ins(6;1)(p21;p13p36). This rearrangement is unusual, and the breakpoints on chromosome 1 are interestingly close to known cellular oncogenes (N-ras, fgr, src-2) and to a putative antioncogene.
authors.affiliation: Center for Genetic Epidemiology and Oncogenetics, National Cancer Institute, Genova, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Sansone
authors.forename: M
authors.initials: M
authors.lastname: Sessarego
authors.forename: R
authors.initials: R
authors.lastname: Haupt
authors.forename: M L
authors.initials: ML
authors.lastname: Garré
authors.forename: P
authors.initials: P
authors.lastname: Strigini
mesh_terms: D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000151:congenital / Q000235:genetics*; D011519:Proto-Oncogenes