Local hydrocortisone treatment of sperm-agglutinating antibodies in infertile women.
Local sperm-agglutinating antibodies (LSAA) in the cervical ovulatory mucus may be a cause of primary infertility. A group of 17 infertile women with LSAA treated without effect with artificial insemination and then condom therapy were studied. After hydrocortisone application to the ectocervix for up to four cycles, LSAA disappeared totally in 13 patients; six of them have given birth to babies. No side effects of treatment were observed. Hydrocortisone for local immunosuppression may become a new method of therapy in cervical immunological infertility.
Ulcová-Gallová
Z
Z
Department of Gynaecology and Obstetrics, Charles University, Pilsen, Czechoslovakia.
Mráz
L
L
Plánicková
E
E
Macků
F
F
Ulc
I
I
D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000906:Antibodies / Q000032:analysis*; D002582:Cervix Mucus / Q000276:immunology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006854:Hydrocortisone; D007247:Infertility, Female / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D011247:Pregnancy; D013073:Sperm Agglutination / Q000187:drug effects*; D013094:Spermatozoa / Q000276:immunology*
D000893:Anti-Inflammatory Agents; D000906:Antibodies; D006854:Hydrocortisone