title: Incorporation and disappearance of oxygen-18 in lung from mice exposed to 1 ppm 18O3.
abstract: In this study, 18O3 was used as a tracer for inhaled ozone in mice. The amount of ozone-derived oxygen (ODO) in the lungs was determined by measuring the amount of oxygen-18 in excess of the natural abundance level which remained covalently bound to organic constituents of lung following exposure to 1 ppm 18O3 for less than or equal to 60 min. The rate of disappearance of ODO from the lungs was determined by quantifying the rate of decrease of oxygen-18 in excess of the natural abundance level in lung from mice exposed to 1 ppm 18O3 for 45 min. With exposure to 1 ppm 18O3. ODO accumulated in lung at a rate of 4.38 pmol/mg dry weight/min. Ozone-derived oxygen had a half-life in lung of approximately 6 hr. We estimate that a minimum of 44 pmol of O3 reacted with lung every minute of exposure to 1 ppm O3.
authors.affiliation: Department of Chemistry, Indiana University, Bloomington 47405.
authors.forename: J
authors.initials: J
authors.lastname: Santrock
authors.forename: G E
authors.initials: GE
authors.lastname: Hatch
authors.forename: R
authors.initials: R
authors.lastname: Slade
authors.forename: J M
authors.initials: JM
authors.lastname: Hayes
mesh_terms: D000818:Animals; D001273:Atmosphere Exposure Chambers; D005260:Female; D008168:Lung / Q000378:metabolism*; D051379:Mice; D010100:Oxygen / Q000378:metabolism* / Q000493:pharmacokinetics; D010103:Oxygen Isotopes; D010126:Ozone / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors
chemical_list: D010103:Oxygen Isotopes; D010126:Ozone; D010100:Oxygen