title: Myocardial involvement and its response to immunosuppressive therapy in nonspecific aortoarteritis (Takayasu's disease)--a study by endomyocardial biopsy.
abstract: Myocardial involvement in nonspecific aortoarteritis was evaluated in 16 patients (age 7-37 years, 2 males, 14 females) with the help of endomyocardial biopsy obtained from the right ventricle using the Cordis bioptome introduced from the right femoral vein. Morphological features of myocarditis were present in 8, endocardial thickening in 2, mild to moderate myofibre hypertrophy in 11, and a normal biopsy in 3 patients. Myocarditis was present in 8/11 cases with active disease and in none with inactive disease. Five of the 8 patients with myocarditis presented with congestive cardiac failure with 3 of them having no associated hypertension or valvar involvement to account for it. Immunosuppressive therapy was given to all patients with myocarditis. Serial studies (ongoing) showed clinical, haemodynamic and morphological improvement. Myocarditis appears to occur commonly in nonspecific aortoarteritis during the acute phase of the disease and may precipitate congestive cardiac failure in some patients. Immunosuppressive therapy shows promise and merits further evaluation.
authors.affiliation: Department of Cardiology, All India Institute of Medical Sciences, New Delhi.
authors.forename: K K
authors.initials: KK
authors.lastname: Talwar
authors.forename: P
authors.initials: P
authors.lastname: Chopra
authors.forename: J
authors.initials: J
authors.lastname: Narula
authors.forename: S
authors.initials: S
authors.lastname: Shrivastava
authors.forename: S K
authors.initials: SK
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.forename: A
authors.initials: A
authors.lastname: Saxena
authors.forename: M
authors.initials: M
authors.lastname: Rajani
authors.forename: M L
authors.initials: ML
authors.lastname: Bhatia
mesh_terms: D000293:Adolescent; D000328:Adult; D001015:Aortic Arch Syndromes / Q000473:pathology*; D001706:Biopsy; D006328:Cardiac Catheterization; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use; D004699:Endocardium / Q000473:pathology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D009205:Myocarditis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use; D013625:Takayasu Arteritis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone