title: Administration of L-2-oxothiazolidine-4-carboxylate increases glutathione levels in rat brain.
abstract: Sterile L-2-oxothiazolidine-4-carboxylate, given as a neutral 100 mmol solution at a dose of 8 mmol/kg subcutaneously, caused an increase in total glutathione concentration in the brain of treated rats. This finding could be important in understanding the role of glutathione in the central nervous system.
authors.affiliation: Department of Neurology, Henry Ford Hospital, Detroit, MI 48202.
authors.forename: J E
authors.initials: JE
authors.lastname: Mesina
authors.forename: R H
authors.initials: RH
authors.lastname: Page
authors.forename: F W
authors.initials: FW
authors.lastname: Hetzel
authors.forename: M
authors.initials: M
authors.lastname: Chopp
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D008297:Male; D011761:Pyrrolidonecarboxylic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D013844:Thiazoles / Q000494:pharmacology*; D053778:Thiazolidines
chemical_list: D013844:Thiazoles; D053778:Thiazolidines; D005978:Glutathione; D011761:Pyrrolidonecarboxylic Acid; C029536:2-oxothiazolidine-4-carboxylic acid