Dominantly inherited childhood gigantism resembling Sotos' syndrome.
Excessive growth in infancy and onset of puberty at age four was observed in a boy with features resembling Sotos syndrome. Early development of secondary sexual characteristics and advanced osseous maturation were observed. The family history was significant; excessive weight gain tended to occur in female family members in association with rapid growth in infancy and childhood. A delayed insulin response to glucose was observed in both mother and sister, and diabetes developed during his mother's gestation. These observations suggest that undetermined factors associated with excessive growth may be inherited as a dominant trait with variable expression.
Blackett
P R
PR
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
Coffman
M A
MA
Schaefer
G B
GB
Rennert
O M
OM
D002648:Child; D002675:Child, Preschool; D005260:Female; D005877:Gigantism / Q000235:genetics*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010375:Pedigree; D013577:Syndrome