title: Reduced glutamate decarboxylase activity in the subthalamic nucleus in patients with tardive dyskinesia.
abstract: Glutamate decarboxylase (GAD) activity was measured in the nuclei of the basal ganglia in patients with neuroleptic-induced tardive dyskinesia (TD) and controls matched for age and premortem state. In five TD patients, who all had a sudden death, a significant decrease in GAD activity was found in the subthalamic nucleus (STN). The lowered GAD activity in the STN may represent a biochemical substrate for neuroleptic-induced TD.
authors.affiliation: Psychiatric Research Center, Ulleråker Hospital, Uppsala, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Andersson
authors.forename: J E
authors.initials: JE
authors.lastname: Häggström
authors.forename: E D
authors.initials: ED
authors.lastname: Levin
authors.forename: U
authors.initials: U
authors.lastname: Bondesson
authors.forename: M
authors.initials: M
authors.lastname: Valverius
authors.forename: L M
authors.initials: LM
authors.lastname: Gunne
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003645:Death, Sudden / Q000473:pathology; D004409:Dyskinesia, Drug-Induced / Q000473:pathology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000172:deficiency*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology; D013787:Thalamic Nuclei / Q000473:pathology*
chemical_list: D005968:Glutamate Decarboxylase