title: Deficiency of autologous mixed lymphocyte reaction in patients with idiopathic autoimmune hemolytic anemia.
abstract: Alterations in the autologous mixed lymphocyte reaction (autologous MLR) have been reported in many autoimmune diseases and in diseases with a derangement of T regulatory function. We have studied autologous MLR in 10 patients with idiopathic autoimmune hemolytic anemia (IAHA). All patients had decreased autologous MLR which averaged 4,106 +/- 1,332 cpm (SEM) compared to 12,153 +/- 4,166 cpm for simultaneously studied controls. A marked decrease in phytohemagglutinin response and an imbalance of T-cell subsets were also observed. These findings suggest a possible abnormality of T immunoregulatory function in IAHA patients.
authors.forename: R
authors.initials: R
authors.lastname: Conte
authors.forename: P L
authors.initials: PL
authors.lastname: Tazzari
authors.forename: C
authors.initials: C
authors.lastname: Finelli
mesh_terms: D000328:Adult; D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D005260:Female; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology
chemical_list: D001324:Autoantigens; D007519:Isoantigens; D010835:Phytohemagglutinins