The relationship between natural killer cells and drugs that modify metastasis of PA-III cells.
Rat prostate adenocarcinoma III (PA-III) cells produce in L-W rats local tumors at the implant site, osteolytic and osteoblastic lesions and metastatic tumors in the lungs. Treatment of rats with dichloromethylene diphosphonate (Cl2MDP) prevented the osteolytic lesions, but the drug showed little beneficial effect on the local and/or metastatic spread of tumor cells. While treatment of rats with piroxicam inhibited PA-III cell metastasis, it manifested only moderate protection against the development of osteolytic lesions. Treatments with both Cl2MDP and piroxicam resulted in smaller tumors, no osteolysis and significantly reduced metastasis. Comparisons of natural killer (NK) cell activities in normal and in tumor-bearing rats, with and without drug treatments, showed that NK cell activity was suppressed by Cl2MDP, and enhanced by piroxicam. When treatments included both drugs, NK cell activity was enhanced. Thus, the suppression of NK cell activity resulting from treatment with Cl2MDP was reversed by piroxicam with resultant benefits from both drugs.
Tazume
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Pollard
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D000230:Adenocarcinoma / Q000276:immunology*; D000818:Animals; D002460:Cell Line; D004002:Clodronic Acid / Q000494:pharmacology; D005260:Female; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008297:Male; D009362:Neoplasm Metastasis; D010894:Piroxicam; D011453:Prostaglandins / Q000502:physiology; D011471:Prostatic Neoplasms / Q000276:immunology* / Q000473:pathology; D051381:Rats; D013843:Thiazines / Q000494:pharmacology
D011453:Prostaglandins; D013843:Thiazines; D004002:Clodronic Acid; D010894:Piroxicam