[Generation of blood anticoagulant and fibrinolytic activity after intravenous administration of protein C-a in rats].
Protein C--vitamin K-dependent protein of the blood coagulation system possessing anticoagulant and fibrinolytic activities was under investigation. Activated partial thromboplastin time was shown to prolong to 214 +/- 8.9% from the first minute after intravenous administration of 0.51 mg per rat bovine protein Ca. After 5 minutes the activity of plasminogen activators increased to 339 +/- 52.8%. Both effects gradually diminished and came back to the starting level within 60-90 minutes. The factor V activity reduced two-fold and didn't return to basal level. We propose that protein Ca reveals its enzymatic activity within first minutes after administration and is blocked then with its inhibitor.
Kogan
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Strukova
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SM
D000293:Adolescent; D000818:Animals; D001777:Blood Coagulation; D005165:Factor V / Q000097:blood; D005342:Fibrinolysis; D006801:Humans; D007275:Injections, Intravenous; D010314:Partial Thromboplastin Time; D010960:Plasminogen Activators / Q000097:blood; D011486:Protein C / Q000008:administration & dosage / Q000502:physiology*; D051381:Rats; D013997:Time Factors
D011486:Protein C; D005165:Factor V; D010960:Plasminogen Activators
Generatsiia antikaguliantnoĭ i fibrinoliticheskoĭ aktivnosti krovi pri vnutrivennom vvedenii proteina C-a krysam.