title: Reduced fetal platelet counts in pregnancies with abnormal Doppler umbilical flow waveforms.
abstract: Fetal and maternal platelet counts were correlated with antenatal assessment of the umbilical-placental waveform. Forty singleton pregnancies were studied using Doppler ultrasound, and placental resistance was categorized as normal or high according to the systolic/diastolic ratio. We performed platelet counts on maternal and cord blood taken at the time of cesarean section. The high-resistance group had a mean fetal platelet count (218 +/- 53 x 10(3)/microliters) significantly lower than that of the normal-resistance group (314 +/- 76 x 10(3)/microliters) (P less than .001). This difference was evident in both the hypertensive and nonhypertensive subgroups of the high-resistance group. There was no difference in mean maternal platelet counts between the high- and normal-resistance groups.
authors.affiliation: Department of Obstetrics and Gynecology, University of Sydney, Westmead Hospital, NSW, Australia.
authors.forename: G R
authors.initials: GR
authors.lastname: Wilcox
authors.forename: B J
authors.initials: BJ
authors.lastname: Trudinger
authors.forename: C M
authors.initials: CM
authors.lastname: Cook
authors.forename: W R
authors.initials: WR
authors.lastname: Wilcox
authors.forename: A J
authors.initials: AJ
authors.lastname: Connelly
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D002585:Cesarean Section; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis; D010920:Placenta / Q000098:blood supply; D010922:Placenta Diseases / Q000175:diagnosis*; D010974:Platelet Aggregation; D010976:Platelet Count; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis; D014465:Ultrasonics; D014469:Umbilical Arteries / Q000502:physiology