Effect of styrene and other alkyl benzene derivatives on oxidation of FAD- and NAD-linked substrates in rat liver mitochondria.
The effect on energetic metabolism of rat liver mitochondria (RLM) of styrene and other aliphatic benzene derivatives, i.e. toluene, ethylbenzene, alpha-methylstyrene and butylbenzene, is studied. It is shown that these compounds uncouple oxidative phosphorylation and this effect is connected with the stimulation of passive entry of protons into mitochondria. The relationship between hydrophobicity of these compounds and their biological activity and mechanism of uncoupling effect are discussed.
Mickiewicz
W
W
Department of General Chemistry, Medical Academy, Gdańsk, Poland.
Rzeczycki
W
W
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D005182:Flavin-Adenine Dinucleotide / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D009243:NAD / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D020058:Styrene; D013343:Styrenes / Q000494:pharmacology*; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid
D005971:Glutamates; D013343:Styrenes; D013386:Succinates; D009243:NAD; D005182:Flavin-Adenine Dinucleotide; D018698:Glutamic Acid; D020058:Styrene; D019802:Succinic Acid; D000251:Adenosine Triphosphatases