Restrictions on use of creatinine clearance for measurement of renal functional reserve.
The increase of glomerular filtration rate after a 90-gram oral protein load was determined in 9 healthy individuals by simultaneous measurements of both creatinine (Ccr) and inulin (Cin) clearances, performed before and every 30 min during 4 h after the meat meal. This protein load resulted in a short 26% increase of Cin at 90 min, and a sustained 29% increase of Ccr from 90 to 240 min after load. Individual peak values of Ccr occurred later than those of Cin (Ccr: 189 +/- 19 vs. Cin: 127 +/- 19 min; p = 0.023). These discrepancies were related to an increase of serum creatinine, and a subsequent increase of the net tubular excretion of creatinine which accounted for up to 15% of the urinary creatinine. The creatinine content of red meat could lead to overestimation of renal functional reserve when measured by creatinine clearance only.
Laville
M
M
Département de Néphrologie, Université Claude-Bernard Lyon I, Unité INSERM U 80-CNRS UA 1177, Hôpital Edouard-Herriot, Lyon, France.
Hadj-Aissa
A
A
Pozet
N
N
Le Bras
J H
JH
Labeeuw
M
M
Zech
P
P
D000328:Adult; D003404:Creatinine / Q000378:metabolism*; D004044:Dietary Proteins / Q000008:administration & dosage; D005919:Glomerular Filtration Rate; D006801:Humans; D007444:Inulin / Q000378:metabolism; D007677:Kidney Function Tests; D008460:Meat
D004044:Dietary Proteins; D007444:Inulin; D003404:Creatinine