title: Management of human papillomavirus-associated genital lesions in men.
abstract: A total of 155 men with human papillomavirus (HPV)-associated genital lesions were studied to evaluate therapy for obvious and subclinical lesions. The treatment methods were selected according to type, location, size, and number of lesions. Seventy-three percent of all patients were successfully treated by the initial therapy. Eighty men with minimal disease had a significantly lower treatment failure rate than 75 men with multiple lesions (15 versus 40%; P less than .001). The type of lesions (classical condyloma versus other HPV-associated lesions), visibility (obvious condylomata versus subclinical lesions), and location did not significantly influence the cure rate (P greater than .05). Seventy-six percent of treatment failures were evident at the first follow-up examination. After a follow-up time of 1 year, 95% of men with obvious condylomata and 93% of men with subclinical lesions were disease-free. The results indicate that obvious and subclinical HPV-associated lesions in men may be successfully controlled by one or more treatment modalities adapted to the particular needs of the patient.
authors.affiliation: Department of Obstetrics and Gynecology, Medical College of Virginia, Richmond.
authors.forename: H B
authors.initials: HB
authors.lastname: Krebs
mesh_terms: D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D003218:Condylomata Acuminata / Q000188:drug therapy / Q000601:surgery; D003452:Cryosurgery; D005472:Fluorouracil / Q000627:therapeutic use; D005832:Genital Diseases, Male / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D005834:Genital Neoplasms, Male / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012008:Recurrence; D015229:Sexually Transmitted Diseases, Viral / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D014412:Tumor Virus Infections / Q000473:pathology / Q000601:surgery / Q000628:therapy*
chemical_list: D005472:Fluorouracil