[Characteristics of memory in MRL/1 mice and the effect of thymic peptides].
By means of methods of active and passive getting rid of electrical-pain irritation we showed that in mice MRL/1--the model of rheumatoid arthritis (RA)--as compared with CBA (control) the process of forming a developed habit engram (DHE) was slowed down and its keeping was impaired. Thymic peptides (thymalin--0.2 mlg/mice intraperitoneally) suppressed the process of forming DHE irrespective of mice line and improved the process of its consolidation and keeping especially in mice MRL/1. Memory impairment in mice with genetical predisposition to the development of autoimmune process (MRL/1) is considered from view of the authors' developed hypothesis about thymus as an organ of antisystem of immune control of homeostasis and RA as an adaptation disease.
Melekhin
V D
VD
Pleskovskaia
G N
GN
Leshchenko
G Ia
GIa
Siniachenko
V V
VV
Nasonova
V A
VA
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains / Q000502:physiology*; D010455:Peptides / Q000494:pharmacology*; D011897:Random Allocation; D013950:Thymus Gland; D013951:Thymus Hormones / Q000494:pharmacology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D010455:Peptides; D013951:Thymus Hormones; C032805:thymalin
Osobennosti pamiati u mysheĭ MRL/1 i vliianie na nee peptidov timusa.