Regulation of brown adipose tissue thermogenesis by corticosterone in obese fa/fa rats.
The defective BAT function of obese Zucker rats has been related primarily to a loss of diet-induced thermogenesis. The normalisation of BAT function by adrenalectomy has been related to the removal of corticosterone. Experiments with propranolol-blockade and on tissue norepinephrine turnover suggest that corticosterone impairs diet-related sympathetic activity but does not alter BAT response to exogenous norepinephrine. The reduction in serum T3 in obese rats is related to the loss of sympathetic activity.
York
D A
DA
Holt
S J
SJ
Marchington
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D
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000315:Adrenalectomy; D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003080:Cold Temperature; D003345:Corticosterone / Q000494:pharmacology*; D004032:Diet; D004435:Eating / Q000187:drug effects; D004734:Energy Metabolism; D008928:Mitochondria / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D009765:Obesity / Q000235:genetics / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011924:Rats, Zucker; D013311:Streptozocin / Q000494:pharmacology
D000450:Aldosterone; D013311:Streptozocin; D011433:Propranolol; D003345:Corticosterone; D009638:Norepinephrine