title: Endusamycin, a novel polycyclic ether antibiotic produced by a strain of Streptomyces endus subsp. aureus.
abstract: Endusamycin formerly called CP-63,517 (C47H77O14Na), is a novel polycyclic ether antibiotic produced by a new strain of Streptomyces endus subsp. aureus (ATCC 39574). Recovery, fractionation and purification were achieved using standard procedures. Forms include the endusamycin free acid, mp 95 approximately 105 degrees C, lambda max 232 nm (log E 4.16), [alpha]25D +47.4 degrees (c 0.5, methanol) and a crystalline sodium salt, mp 215 approximately 220 degrees C, lambda max 232 nm, (log E 4.15), [alpha]25D +25 degrees (c 0.5, methanol). The structure is shown below, Fig. 1. Endusamycin exhibited; antibacterial activity, in vitro against Gram-positive and anaerobic bacteria, effectiveness against coccidia in poultry, and stimulation of propionic acid production in an in vitro system.
authors.affiliation: Central Research, Pfizer Inc., Nagoya, Japan.
authors.forename: J R
authors.initials: JR
authors.lastname: Oscarson
authors.forename: J
authors.initials: J
authors.lastname: Bordner
authors.forename: W D
authors.initials: WD
authors.lastname: Celmer
authors.forename: W P
authors.initials: WP
authors.lastname: Cullen
authors.forename: L H
authors.initials: LH
authors.lastname: Huang
authors.forename: H
authors.initials: H
authors.lastname: Maeda
authors.forename: P M
authors.initials: PM
authors.lastname: Moshier
authors.forename: S
authors.initials: S
authors.lastname: Nishiyama
authors.forename: L
authors.initials: L
authors.lastname: Presseau
authors.forename: R
authors.initials: R
authors.lastname: Shibakawa
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004987:Ethers / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D051381:Rats; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D004987:Ethers; C058736:endusamycin