Oxidative stress leads to inhibition of calcium transport by sarcoplasmic reticulum in skeletal muscle.
Iron administration results in the development of oxidative stress in skeletal muscles, as evidenced by increases in amounts of lipid oxidation fluorescent end products, decreases in vitamin E concentration, and inhibition of calcium transport by sarcoplasmic reticulum. Exhaustive physical loading or hyperoxia, or their combination, does not lead to apparent modification in calcium transport by sarcoplasmic reticulum in skeletal muscle homogenates. However, physical loading or hyperoxia does in fact induce oxidative stress since they magnify the effect of iron loading on the inhibition of calcium transport.
Kagan
V E
VE
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Bakalova
R A
RA
Rangelova
D S
DS
Stoyanovsky
D A
DA
Koynova
G M
GM
Wolinsky
I
I
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D007501:Iron / Q000633:toxicity; D007700:Kinetics; D015227:Lipid Peroxidation; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D010100:Oxygen / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism; D013550:Swimming; D014810:Vitamin E / Q000032:analysis
D014810:Vitamin E; D007501:Iron; D010100:Oxygen; D002118:Calcium