Age-dependence of the solubility fractions of acetylcholinesterase in the cerebral cortex and cerebellum of the rat.
Choline acetyltransferase (ChAT) activity in the cerebral cortex and the different solubility fractions of acetylcholinesterase (AChE) in the cerebral cortex and cerebellum were investigated in rats of different ages. ChAT activity was not decreased markedly in the cerebral cortex of 24- to 25-month-old rats compared to 3- to 4-month-old rats. The activity of detergent-soluble (DS) AChE in the cerebral cortex and cerebellum was lower in the older rats (24-25 months) rats than in younger (3-4 months) ones. The activity of DS-AChE in the cerebral cortex and cerebellum did not differ between 10- to 11-month-old and 24- to 25-month-old rats. The activity of low salt soluble (LSS) AChE in the cerebral cortex and cerebellum did not differ between older and younger rats.
Sirviö
J
J
Department of Neurology, University of Kuopio, Finland.
Riekkinen
P J
PJ
Hervonen
A
A
D000110:Acetylcholinesterase / Q000378:metabolism*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D002531:Cerebellum / Q000201:enzymology* / Q000254:growth & development; D002540:Cerebral Cortex / Q000201:enzymology* / Q000254:growth & development; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000201:enzymology
D000110:Acetylcholinesterase