Enhancement of the autologous mixed lymphocyte reaction (AMLR) in children splenectomized after trauma.
Splenectomized individuals have been reported to have many immunological abnormalities. We have studied the proliferative response of T cells in AMLR of nine children who had undergone splenectomy after trauma. T cells from splenectomized patients showed increased proliferative response in AMLR as compared with that observed in parallelly studied controls (38.480 +/- 19.700 vs 11.160 +/- 3.760 dpm). The percentage of CD4 cells was diminished in the group of splenectomized patients. We found strong correlation between AMLR and time after splenectomy (r = -0.81, p less than 0.01). Possible mechanism of elevated AMLR following splenectomy and hypotheses on generation of AMLR are discussed.
Zeman
K
K
Department of Pathophysiology, Military Medical Academy, Lódź.
Tchórzewski
H
H
Płuzańska
A
A
Chilarski
A
A
Majewska
E
E
D000293:Adolescent; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D013154:Spleen / Q000293:injuries*; D013156:Splenectomy