title: Effect of subinhibitory concentrations of tiamulin on the haemagglutinating properties of fimbriated Escherichia coli (K88, K99).
abstract: The haemagglutinating properties (HA) of Escherichia coli possessing the fimbrial antigens K88 and K99 were significantly affected by tiamulin. HA for K88-positive strains was reduced at 1/10 to 1/40 minimum inhibitory concentration (MIC), while the corresponding values for the K99 strains were 1/2 to 1/10 MIC. Tiamulin concentrations of 3 to 12 micrograms ml-1 increased salt aggregation test values from between 1.4 and 1.5, to more than 2.
authors.affiliation: Institute of Hygiene and Microbiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
authors.forename: J L
authors.initials: JL
authors.lastname: Larsen
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D004224:Diterpenes / Q000494:pharmacology; D004926:Escherichia coli / Q000276:immunology*; D010861:Fimbriae, Bacterial / Q000276:immunology*; D006168:Guinea Pigs; D006384:Hemagglutination / Q000187:drug effects*; D006736:Horses; D006801:Humans; D066298:In Vitro Techniques; D011200:Poultry; D013552:Swine
chemical_list: D000942:Antigens, Bacterial; D004224:Diterpenes; C014224:tiamulin