Induction of gamma-glutamyl transpeptidase activity by all-trans retinoic acid in cultured rat liver epithelial cells.
The induction of activity of gamma-glutamyl transpeptidase (GGT) by all-trans retinoic acid in a chemically transformed rat liver epithelial cell line has been investigated. Retinoic acid increased the level of the GGT mRNA and this enhancement was progressive, depending on the duration of exposure and on the concentration of retinoic acid in the culture medium. When retinoic acid was removed from cultures which had been exposed to it for 4 days, the induced GGT activity remained unchanged. In contrast to transformed cell lines, retinoic acid did not induce the activity of GGT in normal/non-transformed rat liver epithelial cells.
Tsao
M S
MS
Department of Pathology, Montreal General Hospital, Quebec, Canada.
Batist
G
G
D000818:Animals; D002460:Cell Line; D002461:Cell Line, Transformed; D004790:Enzyme Induction / Q000187:drug effects; D004848:Epithelium / Q000201:enzymology; D008099:Liver / Q000201:enzymology*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D014212:Tretinoin / Q000494:pharmacology*; D005723:gamma-Glutamyltransferase / Q000096:biosynthesis* / Q000235:genetics
D012333:RNA, Messenger; D014212:Tretinoin; D005723:gamma-Glutamyltransferase