The use of Chinese herb medicine in experimental radiotherapy.
Extracts from a group of destagnative herbs, 764-1, and the effective chemical, 764-3, were tested by an in vitro experiment using a HeLa-S3 cell line. Under aerobic conditions, the shoulder of the cell survival curve diminished or disappeared according to the different doses of 764-1 used, but no change in slope was observed. In nitrogen, when the dose of 764-1 increased to 20 mg/ml (ID20), besides the disappearance of the shoulder, the slope of the curve also showed changes at lower doses (4-8 Gy); up to 10-25 Gy the curve became more flattened. 764-3 showed almost a similar effect by mainly affecting the shoulder of the survival curve. At low drug doses a SER as high as 1.87 might be obtained under hypoxic condition. At the same time 764-1 was used in testing the effect on radiation lung damage. It was found that 764-1 could markedly inhibit the change of alveolar surfactant at 1 and 3 weeks after radiation. A wide field of investigation is thus spread out in front of us on radiosensitization and protection. Further studies on 764-3 are carried out.
Shen
Y
Y
Dept. Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing.
Yang
X Y
XY
Zhan
Q M
QM
Guo
R
R
Liu
J W
JW
Yang
C Z
CZ
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung / Q000528:radiation effects; D008297:Male; D051379:Mice; D011663:Pulmonary Surfactants / Q000528:radiation effects; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D011663:Pulmonary Surfactants; D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents