title: Inhibitory effect of sulphur-containing purine nucleoside analogues on replication of RNA viruses: selective antiviral activity against influenza viruses.
abstract: Four sulphur-containing purine nucleoside analogues: 6MP, 6-thioinosine, 6-methylthioinosine and 6-ethylthioinosine, were examined for antiviral activity against some RNA viruses. All compounds extensively inhibited the replication of influenza viruses but had no inhibitory effect on other RNA viruses: Sendai, RS, vesicular stomatitis and western equine encephalitis viruses.
authors.affiliation: Department of Virology and Rickettsiology, National Institute of Health, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Hasobe
authors.forename: M
authors.initials: M
authors.lastname: Saneyoshi
mesh_terms: D000582:Amidophosphoribosyltransferase / Q000037:antagonists & inhibitors; D000818:Animals; D000998:Antiviral Agents; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D009975:Orthomyxoviridae / Q000187:drug effects*; D011684:Purine Nucleosides / Q000494:pharmacology*; D012328:RNA Viruses / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D011684:Purine Nucleosides; D000582:Amidophosphoribosyltransferase