Endocytosis-inducer adhesins produced by enteropathogenic serogroups of Escherichia coli participate on bacterial attachment to infant enterocytes.
Enteropathogenic E. coli (EPEC) infection of Hep-2 cells proceeds through bacterial attachment to cell surface and internalization of adhered bacteria. EPEC attachment is a prerequisite for cell infection and is mediated by adhesins that recognize carbohydrate-containing receptors on cell membrane. Such endocytosis-inducer adhesins (EIA) also promote EPEC binding to infant enterocytes, suggesting that EIA may have an important role on EPEC gastroenteritis.
Andrade
J R
JR
Serviço de Microbiologia e Imunologia, Faculdade de Ciências Médicas. UERJ. Rua Manuel de Abreu, Rio de Janeiro, Brasil.
Da Silva
C C
CC
D018830:Adhesins, Escherichia coli; D001422:Bacterial Adhesion; D001425:Bacterial Outer Membrane Proteins / Q000502:physiology*; D003968:Diarrhea, Infantile / Q000209:etiology*; D004705:Endocytosis; D004926:Escherichia coli / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D007223:Infant; D014774:Virulence
D018830:Adhesins, Escherichia coli; D001425:Bacterial Outer Membrane Proteins