title: Inhibition by retinoids of in vitro invasive ability of human lung carcinoma cells.
abstract: The effect of retinoid treatment of A549 human lung carcinoma cells on in vitro cell invasion using the human amnion basement membrane (BM) was investigated. A 2-day retinoid pretreatment of the cells resulted in a significant reduction in their invasive ability. The most effective retinoid, retinol acetate, inhibited cell migration through the BM and degradation of [3H] proline labeled BM components by 50% at noncytotoxic concentrations of 0.09, and 3 micrograms/ml, respectively. Inhibition by retinol acetate of A549 cell invasive potential was accompanied by a significant decrease in type IV collagenase activity and no change in transglutaminase activity.
authors.affiliation: Department of Biology, University of Akron, Ohio 44325.
authors.forename: F
authors.initials: F
authors.lastname: Fazely
authors.forename: N
authors.initials: N
authors.lastname: Ledinko
authors.forename: D J
authors.initials: DJ
authors.lastname: Smith
mesh_terms: D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects; D004224:Diterpenes; D006801:Humans; D007700:Kinetics; D008175:Lung Neoplasms / Q000201:enzymology / Q000473:pathology*; D003012:Microbial Collagenase / Q000378:metabolism; D009361:Neoplasm Invasiveness; D000084562:Retinyl Esters; D011503:Transglutaminases / Q000378:metabolism; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate; D011503:Transglutaminases; D003012:Microbial Collagenase