title: Effect of prosthetic mitral valve geometry and orientation on flow dynamics in a model human left ventricle.
abstract: Pulsatile flow dynamics through bileaflet (St Jude and Duromedics), tilting disc (Bjork-Shiley and Omniscience), caged ball (Starr-Edwards), pericardial (Edwards) and porcine (Carpentier-Edwards) mitral valves in a model human left ventricle (LV) were studied. The model human ventricle, obtained from an in situ diastolic casting, was incorporated into a mock circulatory system. Measurements were made at various heart rates and flow rates. These included the transvalvular pressure drop and regurgitation in percent and cm3 beat-1. The effect of valve geometry and the orientation of the valve with respect to the valve annulus was analyzed using a flow visualization technique. Qualitative flow visualization study indicates certain preferred orientations for the tilting disc and bileaflet valve prostheses in order to obtain a smooth washout of flow in the LV chamber.
authors.affiliation: Department of Biomedical, University of Iowa, Iowa City.
authors.forename: K B
authors.initials: KB
authors.lastname: Chandran
authors.forename: R
authors.initials: R
authors.lastname: Schoephoerster
authors.forename: K C
authors.initials: KC
authors.lastname: Dellsperger
mesh_terms: D006321:Heart / Q000502:physiology*; D006350:Heart Valve Prosthesis; D006801:Humans; D008943:Mitral Valve; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D011312:Pressure; D012039:Regional Blood Flow; D012212:Rheology