title: Immunoreactive SOD-1 in amniotic fluid, amniotic cells and fibroblasts from trisomy 21 fetus.
abstract: Copper superoxide dismutase (Cu-SOD or SOD-1) was measured by radioimmunoassay (RIA) in amniotic cells and fluid as well as in fetal trisomy 21 fibroblasts. The significant increase of the SOD-1 activity observed in amniotic cells and fetal trisomy 21 fibroblasts demonstrates the early physiopathogenic expression of the supernumerary chromosome 21 in affected patients.
authors.forename: M A
authors.initials: MA
authors.lastname: Baeteman
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: A
authors.initials: A
authors.lastname: Baret
authors.forename: M
authors.initials: M
authors.lastname: Gamerre
authors.forename: J F
authors.initials: JF
authors.lastname: Mattei
mesh_terms: D000328:Adult; D000649:Amniocentesis; D000650:Amnion / Q000201:enzymology*; D000653:Amniotic Fluid / Q000201:enzymology*; D004314:Down Syndrome / Q000201:enzymology*; D005260:Female; D005347:Fibroblasts / Q000201:enzymology*; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D018566:Pregnancy, High-Risk; D011863:Radioimmunoassay; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D013482:Superoxide Dismutase