title: Behavioral hyporeactivity to physostigmine in detoxified primary alcoholics.
abstract: Changes in anergia/inhibition, mood, and pulse rate induced by intravenous physostigmine were significantly less pronounced in 26 patients with primary alcoholism than in 36 normal control subjects. These results suggest possible abnormalities in central cholinergic functioning in primary alcoholics.
authors.affiliation: Psychiatry Service, San Diego, VA Medical Center.
authors.forename: D S
authors.initials: DS
authors.lastname: Janowsky
authors.forename: S C
authors.initials: SC
authors.lastname: Risch
authors.forename: M
authors.initials: M
authors.lastname: Irwin
authors.forename: M A
authors.initials: MA
authors.lastname: Schuckit
mesh_terms: D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000503:physiopathology*; D004644:Emotions / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010830:Physostigmine / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000502:physiology*
chemical_list: D011950:Receptors, Cholinergic; D010830:Physostigmine