Aging and Alzheimer's disease. Altered cortical serotonergic binding.
The binding of tritiated serotonin and tritiated spiperone to crude membrane preparations from human frontal poles was determined in both controls and subjects with Alzheimer's disease (AD). Using the dopamine-specific receptor antagonist sulpiride, spiperone binding in the cortex was shown to be essentially serotonergic. A decline in both serotonin and spiperone binding was found in normal aging, and an AD-related decrease was found for spiperone binding only. The AD-related decrement of spiperone binding occurred irrespective of patient age and duration of disease. Scatchard analysis indicates that both age- and disease-related decrements represent a decrease in receptor number.
Sparks
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Sanders-Brown Research Center on Aging, Department of Neurology, University of Kentucky Medical Center, Lexington 40536-0230.
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D005625:Frontal Lobe / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D012016:Reference Values; D012701:Serotonin / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism
D012701:Serotonin; D013134:Spiperone