Calcium and olfactory transduction.
1. Inorganic cations, organic calcium antagonists, and calmodulin antagonists were applied to olfactory epithelia of frogs (Rana pipiens) while recording electroolfactogram (EOG) responses. 2. Inorganic cations inhibited EOGs in a rank order, reflecting their calcium channel blocking potency: La3+ greater than Zn2+ greater than Cd2+ greater than Al3+ greater than Ca2+ greater than Sr2+ greater than Co2+ greater than Ba2+ greater than Mg2+. Barium ion significantly enhanced EOGs immediately following application. 3. Diltiazem and verapamil produced dose-dependent EOG inhibition. 4. Calmodulin antagonists inhibited EOGs without correlation to their anti-calmodulin potency.
Winegar
B D
BD
Department of Biological Sciences, University of North Texas, Denton 76203-5218.
Rosick
E R
ER
Schafer
R
R
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002147:Calmodulin / Q000037:antagonists & inhibitors; D002412:Cations / Q000494:pharmacology; D004594:Electrophysiology; D009831:Olfactory Mucosa / Q000187:drug effects / Q000502:physiology*; D011894:Rana pipiens
D002121:Calcium Channel Blockers; D002147:Calmodulin; D002412:Cations; D002118:Calcium