title: Failure of hysteroscopic insemination of the fallopian tube in synchronized cycles.
abstract: The study consisted of a randomized, controlled trial of synchronized hysteroscopic insemination of the fallopian tube (SHIFT), in which selected infertile couples underwent hormonal delay of menstruation, ovulation induction, and insemination of a selected motile sperm population into the tubal isthmus above the utero-tubal junction. Of 40 couples recruited, only 2 became pregnant, both during a nonsynchronized control cycle. No conceptions were reported in either the 72 SHIFT or 73 non-SHIFT synchronized cycles. Hysteroscopic insemination was found to be a relatively easy procedure with a low rate of technical failure. There was low morbidity with no major clinical complications. However, 57% of tracked synchronized cycles showed a failed response to the follicular stimulation protocol; and 91% showed failure of follicular rupture greater than or equal to 52 hours after hCG induction. These failures of the ovulation synchronization/induction regimen were probably due to the use of medroxyprogesterone acetate for cycle synchronization, and should not preclude further evaluation of the technique of hysteroscopic insemination.
authors.affiliation: Department of Ob/Gyn, University of Calgary Health Sciences Centre, Alberta, Canada.
authors.forename: J H
authors.initials: JH
authors.lastname: Brooks
authors.forename: D
authors.initials: D
authors.lastname: Mortimer
authors.forename: P J
authors.initials: PJ
authors.lastname: Taylor
mesh_terms: D002986:Clinical Trials as Topic; D004724:Endoscopy / Q000379:methods; D005187:Fallopian Tubes; D005260:Female; D006801:Humans; D007315:Insemination, Artificial / Q000379:methods*; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D008297:Male; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011897:Random Allocation; D013075:Sperm Capacitation