[The role of infection in the precipitation of periarteritis nodosa].
Circulating immune complexes are thought to play an essential part in the pathogenesis of necrosing angiitis. This theory also allows a role to be attributed to certain infectious agents (viral, bacterial, parasitic) in the development of periarteritis nodosa (PAN). An infectious syndrome was found in all our 9 patients, aged 26 to 69 years, with histologically confirmed PAN: previous infection (over 15 days before hospital admission): otitis, hepatitis B, tonsillitis, ascaris (Case n.7), pulmonary tuberculosis, brucellosis, seropositivity for Chlamydia trachomatis (Case n.9), paratyphoid (Case n.5), seropositivity for Yersiniosis pseudo-tuberculosis (Case n.2), seropositivity for Chlamydia trachomatis (Cases 3 and 4), seropositivity for toxoplasmosis (Cases 4 and 6), seropositivity for rubella (Case n.8). Recent infection (less than 15 days before hospital admission): staphylococcus aureus septicaemia (Case n.1); Group A betahemolytic streptococcal urinary infection (Case n.2); Group A betahemolytic streptococcal otitis media; pseudomonas aeruginosa and Klebsiella septicaemia; enterococcal cystitis (Case n.4); progressive pulmonary tuberculosis (Case n.6), acinetobacter pneumonia (Case n.9). The HBs antigen was only found in one patient (Case n.6), who had an active hepatitis.
Smail
A
A
Service de Médecine Interne, Centre Hospitalier et Universitaire, Hôpital Nord, Amiens.
Ducroix
J P
JP
Tondriaux
A
A
Sevestre
H
H
Yzet
T
T
Baillet
J
J
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000150:complications*; D004198:Disease Susceptibility; D005260:Female; D006509:Hepatitis B / Q000150:complications; D006511:Hepatitis B Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010034:Otitis Media with Effusion / Q000150:complications; D010272:Parasitic Diseases / Q000150:complications*; D010488:Polyarteritis Nodosa / Q000209:etiology* / Q000276:immunology; D014777:Virus Diseases / Q000150:complications*
D006511:Hepatitis B Antigens
Rôle de l'infection dans le déclenchement des angéites nécrosantes.