Effects of indomethacin on bone ingrowth.
The effects of indomethacin, a nonsteroidal antiinflammatory agent, on bone ingrowth were studied using a rabbit animal model and a porous cylindrical implant system. Bone ingrowth was found to be independent of pore size in the range tested (0.6-1.0 mm). In the control (placebo-treated) group, there was a significant increase in bone ingrowth between the 2- and 8-week groups of animals. However, in the indomethacin-treated group, there was no increase in bone ingrowth with time.
Keller
J C
JC
Department of Materials Science, Medical University of South Carolina, Charleston.
Trancik
T M
TM
Young
F A
FA
St Mary
E
E
D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D001842:Bone and Bones / Q000473:pathology; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D019736:Prostheses and Implants; D011817:Rabbits; D013997:Time Factors
D007213:Indomethacin