High-dose depot-medroxyprogesterone acetate--effects on the fatty acid composition of serum lecithin and cholesterol ester.
Twenty-one women were treated with high doses of depot-medroxyprogesterone acetate (1000 mg/week im) for 6 months as part of the treatment of endometrial carcinoma. The relative fatty acid composition of serum lecithin and cholesterol ester were analyzed. In previous studies low doses of medroxyprogesterone acetate (MPA), in contrast to progestins of the 19-nor-testosterone series, have been shown not to affect the fatty acid composition of serum lecithin and cholesterol ester. However, the high doses of MPA used in this study increased linoleic acid and decreased arachidonic and di-homogammalinolenic acids in serum lecithin. The ability of a steroid to induce this shift has been ascribed to its androgenicity. MPA is considered to have weak, if any, such properties. The findings of this study emphasize the necessity to delineate effects on metabolism of different doses and administrative routes of any particular steroid.
Enk
L
L
Crona
N
N
Friberg
L G
LG
Samsioe
G
G
Silfverstolpe
G
G
D015126:8,11,14-Eicosatrienoic Acid / Q000032:analysis; D000368:Aged; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000032:analysis; D002788:Cholesterol Esters / Q000097:blood*; D005227:Fatty Acids / Q000032:analysis*; D005260:Female; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000032:analysis; D008525:Medroxyprogesterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D017258:Medroxyprogesterone Acetate; D008875:Middle Aged; D010169:Palmitic Acids / Q000032:analysis; D010713:Phosphatidylcholines / Q000097:blood*; D013229:Stearic Acids / Q000032:analysis; D014594:Uterine Neoplasms / Q000097:blood* / Q000188:drug therapy
D001095:Arachidonic Acids; D002788:Cholesterol Esters; D005227:Fatty Acids; D008041:Linoleic Acids; D010169:Palmitic Acids; D010713:Phosphatidylcholines; D013229:Stearic Acids; D016718:Arachidonic Acid; C031183:stearic acid; D019787:Linoleic Acid; D017258:Medroxyprogesterone Acetate; D015126:8,11,14-Eicosatrienoic Acid; D008525:Medroxyprogesterone