title: Effect of clindamycin on factor-VII activity in healthy cats.
abstract: Four healthy cats were given clindamycin orally in daily doses of 25 or 50 mg/kg of body weight for 6 weeks. Significant change in Factor-VII activity was not found, compared with pretreatment values. In 2 cats tested, toxin produced by Clostridium difficile was not detected in fecal samples obtained before treatment and at 6 weeks after treatment, suggesting that intestinal overgrowth by C difficile did not develop. Results of the study seemed to indicate that orally administered clindamycin does not measurably reduce synthesis of vitamin K-dependent clotting factors in healthy cats.
authors.affiliation: Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
authors.forename: G
authors.initials: G
authors.lastname: Jacobs
authors.forename: M
authors.initials: M
authors.lastname: Lappin
authors.forename: A
authors.initials: A
authors.lastname: Marks
authors.forename: C E
authors.initials: CE
authors.lastname: Greene
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D002371:Cat Diseases / Q000139:chemically induced; D002415:Cats / Q000097:blood*; D002981:Clindamycin / Q000633:toxicity*; D005167:Factor VII / Q000378:metabolism*; D005260:Female; D008297:Male; D014839:Vomiting / Q000139:chemically induced / Q000662:veterinary
chemical_list: D002981:Clindamycin; D005167:Factor VII