Gadolinium-phthalein complexone as a contrast agent for hepatobiliary MR imaging.
Gadolinium-phthalein complexone (Gd-PC) was developed as a hepatobiliary magnetic resonance (MR) contrast agent. Phthalein complexone is one of the iminodiacetic acid derivatives and a structural analogue of bromosulfophthalein. Gadolinium-PC substantially enhanced signal intensity of normal functioning livers on T1-weighted MR images. Contrast enhancement of rabbit liver and gradual accumulation of high intensity bile in the gallbladder were observed after intravenous injection of 0.05 and 0.1 mmol/kg Gd-PC. However, 0.1 mmol/kg of Gd-DTPA caused little effect on liver MR.
Kawamura
Y
Y
Department of Nuclear Medicine, School of Medicine, Kyoto University, Japan.
Endo
K
K
Koizumi
M
M
Watanabe
Y
Y
Saga
T
T
Konishi
J
J
Horiuchi
K
K
Yokoyama
A
A
D000818:Animals; D001659:Biliary Tract / Q000033:anatomy & histology*; D005682:Gadolinium; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds; D010635:Phenolphthaleins; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium
D009942:Organometallic Compounds; D010635:Phenolphthaleins; C058344:gadolinium-phthalein complexone; D013667:Technetium; D005682:Gadolinium