[Techniques of DNA polymorphisms revealed by probes for the Y chromosome applied to questions of father-son line in analyses of paternity].
The Y specific probe (two 49f and 49a sub-clones) is a polymorphic one for the A (5 alleles), C (2 alleles), D (3 alleles), F (2 alleles) and I (2 alleles). We show that the corresponding allelic combinations, or haplotypes, are transmitted father-to-son in eleven random chosen families. Utilisation of these polymorphisms in other eleven father-son paternitity cases, studied for a panel of erythrocytic and seric markers, shows a good correlation between the two approaches, most of the paternies excluded by the Y probes being also excluded with other allotypic markers. Utilisation of this sort of polymorphism does not necessitate the knowledge of maternal genotype in families studied.
Guérin
P
P
Laboratoire de Génétique Moléculaire, Institut National de Transfusion Sanguine, Paris.
Berriche
S
S
Intrator
S
S
Rouger
P
P
Salmon
D
D
Salmon
C
C
Lucotte
G
G
D015342:DNA Probes; D006801:Humans; D010334:Paternity; D010375:Pedigree; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D014998:Y Chromosome
D015342:DNA Probes
Les techniques de polymorphismes de l'A.D.N. de sondes du chromosome Y appliquées au problème de filiations père-fils dans les analyses de paternité.