The role of platelet-activating factor in experimental immune complex pathology.
Tissue localization of immune complexes (IC) after infusion of synthetic platelet-activating factor (PAF) in rabbits was studied. Bovine serum albumin (BSA) was injected intravenously either before or after the infusion of synthetic PAF, later followed by the administration of anti-BSA antibodies over a 30-min period. Control rabbits received both BSA and anti-BSA antibodies, followed by lyso-PAF or saline-BSA instead of PAF. The infusion of PAF induced structural alterations in the heart, lung and kidney which were consistent with an increased vascular permeability. Deposits of BSA, IgG, and C3 were found in the heart, lung, and kidney of rabbits infused with PAF but not in control rabbits. In the liver of PAF-infused rabbits, immune deposits were only infrequently observed, whereas they were constantly present in the cardiac valves, thoracic aorta and at the bifurcation of the renal artery as they were in the control rabbits. These results suggest that PAF favors the localization of IC in the heart, lung and kidney vessels but does not influence the formation of immune deposits at the sites of turbulence of the blood flow.
Camussi
G
G
Tetta
C
C
Alberton
M
M
Roffinello
C
C
Mariano
F
F
Mularoni
E
E
Coda
R
R
Macchiorlatti
E
E
Montrucchio
G
G
D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism; D001808:Blood Vessels / Q000276:immunology; D002199:Capillary Permeability / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury; D003176:Complement C3 / Q000378:metabolism; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced / Q000473:pathology; D007105:Immune Complex Diseases / Q000503:physiopathology*; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced / Q000473:pathology; D008297:Male; D010972:Platelet Activating Factor / Q000494:pharmacology / Q000502:physiology* / Q000633:toxicity; D011817:Rabbits
D000936:Antigen-Antibody Complex; D003176:Complement C3; D010972:Platelet Activating Factor