Inhibition of allergic contact dermatitis and ultraviolet radiation-induced tissue swelling in the mouse by topical amiloride.
Amiloride is known to inhibit membrane sodium transport and has been shown in vitro to inhibit cell activation and proliferation in several model systems. These effects occur at relatively high local concentrations of amiloride. We studied the cutaneous response to the topical application of amiloride hydrochloride. Our observations demonstrated that topical application of amiloride was potent in its ability to inhibit murine tissue swelling and inflammation in response to contact sensitizing agents and ultraviolet radiation. These observations might suggest a role for amiloride or its analogues as topical anti-inflammatory or antiproliferative drugs.
Gallo
R L
RL
Wellman Laboratory, Department of Dermatology, Massachusetts General Hospital, Boston 02114.
Granstein
R D
RD
D000279:Administration, Cutaneous; D000287:Administration, Topical; D000584:Amiloride / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents; D003877:Dermatitis, Contact / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D011833:Radiation Injuries, Experimental / Q000188:drug therapy; D014466:Ultraviolet Rays
D000893:Anti-Inflammatory Agents; D000584:Amiloride