title: Modality-specific antinociception produced by intrathecal injection of anti-somatostatin antiserum in rats.
abstract: An intrathecal injection of antiserum against somatostatin significantly inhibited the nociceptive response to thermal but not mechanical stimulation in non-arthritic and adjuvant arthritic rats. The thermal antinociception induced by intrathecally injected anti-somatostatin antiserum was more remarkable in adjuvant arthritic rats than in non-arthritic ones. These results suggest that endogenous somatostatin participates in transmission of thermal nociception in the rat spinal dorsal horn in non-arthritic and arthritic conditions.
authors.affiliation: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ohno
authors.forename: Y
authors.initials: Y
authors.lastname: Kuraishi
authors.forename: M
authors.initials: M
authors.lastname: Minami
authors.forename: M
authors.initials: M
authors.lastname: Satoh
mesh_terms: D000818:Animals; D006358:Hot Temperature; D007106:Immune Sera / Q000494:pharmacology*; D007278:Injections, Spinal; D008297:Male; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000378:metabolism*; D010812:Physical Stimulation; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000276:immunology / Q000502:physiology*
chemical_list: D007106:Immune Sera; D013004:Somatostatin