title: 1',2'-seco-dideoxynucleosides as potential anti-HIV agents.
abstract: 1',2'-seco-2',3'-Dideoxycytidine (12), -guanosine (14), -adenosine (16), and -inosine (18) were prepared from (R)-benzylglycidol as potential anti-HIV agents. When compared to ddAdo in protecting ATH8 cells, they were found to be inactive.
authors.affiliation: Department of Medicinal Chemistry, University of Rhode Island, Kingston 02118.
authors.forename: E
authors.initials: E
authors.lastname: Abushanab
authors.forename: M S
authors.initials: MS
authors.lastname: Sarma
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D006678:HIV / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D015224:Dideoxynucleosides