title: [Effects of preliminary fasting on the development of D-galactosamine-induced acute lesion of the liver in rats].
abstract: The effect of 48-hour preliminary fasting on the development of acute hepatitis in 24 h after the use of 1,855 mmol D-galactosamine per 1 kg bw has been studied on rats. Both intensification of dystrophic and necrotic processes in the liver and aggravation of ultrastructural changes and disorders have been observed. Concentrations of reduced glutathione in the liver and D-glucaric acid in the urine are not changed under the effect of intoxication.
authors.forename: D
authors.initials: D
authors.lastname: Adzharov
authors.forename: N
authors.initials: N
authors.lastname: Donchev
authors.forename: M
authors.initials: M
authors.lastname: Kerimova
authors.forename: E
authors.initials: E
authors.lastname: Naĭdenova
authors.forename: B
authors.initials: B
authors.lastname: Borov
mesh_terms: D000208:Acute Disease; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005215:Fasting; D005688:Galactosamine; D005977:Glutarates / Q000652:urine; D005978:Glutathione / Q000378:metabolism; D006965:Hyperplasia; D006984:Hypertrophy; D008099:Liver / Q000473:pathology; D008297:Male; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005977:Glutarates; D005688:Galactosamine; D003577:Cytochrome P-450 Enzyme System; D005978:Glutathione; C035736:glutaric acid
vernacular_title: Vliianie predvaritel'nogo golodaniia na razvitie ostrogo povrezhdeniiapecheni D-galaktozaminom u krys.