Regional localization of the TIMP gene on the human X chromosome. Extension of a conserved synteny and linkage group on proximal Xp.
The gene encoding a tissue inhibitor of metallo-proteinases, TIMP, has previously been shown to be X-linked in both the human and mouse genomes. We have used a series of somatic cell hybrids segregating translocation and deletion X chromosomes to map the TIMP gene on the human X chromosome. In combination with previous data, the gene can be assigned to Xp11.23----Xp11.4. Genetic linkage analyses demonstrate that TIMP is linked to the more distal ornithine transcarbamylase (OTC) locus at a distance of about 22 centimorgans. The data are consistent with the conclusion that TIMP maps to a conserved synteny and linkage group on the proximal short arm of the human X chromosome and on the pericentric region of the mouse X chromosome, including loci for synapsin-1, a member of the raf oncogene family, OTC, and TIMP.
Willard
H F
HF
Department of Medical Genetics, University of Toronto, Ontario, Canada.
Durfy
S J
SJ
Mahtani
M M
MM
Dorkins
H
H
Davies
K E
KE
Williams
B R
BR
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D006224:Cricetinae; D015342:DNA Probes; D004791:Enzyme Inhibitors / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D019714:Tissue Inhibitor of Metalloproteinases; D014960:X Chromosome
D015342:DNA Probes; D004791:Enzyme Inhibitors; D019714:Tissue Inhibitor of Metalloproteinases; D008666:Metalloendopeptidases