Microvascular anastomoses in diabetes: an experimental study.
The process of intimal repair across a microvascular anastomosis has been studied in an animal model of diabetes using scanning electron microscopy. The mean area of re-endothelialisation at 10 days, 200 microns on either side of an experimental microarterial anastomosis, was 65% in nondiabetic controls compared to 16.5% in an untreated diabetic group and 10% in an insulin treated diabetic group. The degree of intimal repair was significantly lower in the diabetic groups compared to controls (p less than 0.01, Wilcoxon Rank Test). Defective re-endothelialisation may contribute to anastomotic failure in clinical practice.
Barr
L C
LC
Academic Surgical Unit, Westminster Hospital, London.
Joyce
A D
AD
D000714:Anastomosis, Surgical; D000818:Animals; D001158:Arteries / Q000601:surgery* / Q000648:ultrastructure; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000601:surgery; D004730:Endothelium, Vascular / Q000503:physiopathology / Q000648:ultrastructure; D005260:Female; D008855:Microscopy, Electron, Scanning; D008866:Microsurgery; D051381:Rats; D011919:Rats, Inbred Strains; D014945:Wound Healing