title: Gallbladder motility before and after extracorporeal shock-wave lithotripsy.
abstract: To determine whether extracorporeal shock-wave lithotripsy of gallbladder stones alters gallbladder motility, gallbladder contraction in response to intravenous cholecystokinin was investigated by ultrasound. Twenty-one patients with symptomatic gallstones were studied before and after shock-wave lithotripsy, 12 with and 9 without concomitant litholytic therapy (combination of ursodeoxycholic acid and chenodeoxycholic acid). Gallbladder emptying was significantly delayed and less complete in both groups of patients before shock-wave treatment (with bile salts: residual volume, 51% +/- 10% and half-ejection time, 40 +/- 5 min; without bile salts: residual volume, 46% +/- 7%; half-ejection time, 30 +/- 4 min) compared with healthy controls (residual volume, 15% +/- 4%; half-ejection time, 18 +/- 2 min). Gallbladder motility was not altered in either group 1 day and 1 yr after lithotripsy. The findings indicate (a) that extracorporeal shock-wave lithotripsy has no immediate or long-term adverse effects on gallbladder motility and (b) that the defect of gallbladder motility associated with gallstone disease is not abolished by removal of the stone.
authors.affiliation: Department of Internal Medicine II, University of Munich, Federal Republic of Germany.
authors.forename: U
authors.initials: U
authors.lastname: Spengler
authors.forename: M
authors.initials: M
authors.lastname: Sackmann
authors.forename: T
authors.initials: T
authors.lastname: Sauerbruch
authors.forename: J
authors.initials: J
authors.lastname: Holl
authors.forename: G
authors.initials: G
authors.lastname: Paumgartner
mesh_terms: D000328:Adult; D002635:Chenodeoxycholic Acid / Q000627:therapeutic use; D002766:Cholecystokinin; D002769:Cholelithiasis / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D005704:Gallbladder / Q000503:physiopathology*; D006801:Humans; D008096:Lithotripsy; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D010528:Peristalsis; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
chemical_list: D002635:Chenodeoxycholic Acid; D014580:Ursodeoxycholic Acid; D002766:Cholecystokinin