title: Partial laryngectomy and radiotherapy for supraglottic cancer: a conservative approach.
abstract: This is a retrospective study of 33 patients with supraglottic cancer treated with partial laryngectomy and moderate-dose radiotherapy at the University of Virginia from 1967 through 1986. All patients had a 2-year minimum follow-up. Ten patients received preoperative radiotherapy, and 23, postoperative radiotherapy. The 2-year adjusted survival rate was impressive at 97%. Local control at 2 years was 96%, including one patient who was salvaged with total laryngectomy. Control of the neck was 90% at 2 years. Ninety percent of the patients alive at 2 years had a functional voice. One patient required a completion laryngectomy for chronic aspiration. Conservation surgery with radiotherapy provides excellent survival as well as locoregional control rates with preservation of function in selected patients with supraglottic cancer. This approach may be especially helpful in the management of bulky T2 lesions as well as T4 lesions with minimal vallecula or base of tongue involvement.
authors.affiliation: Division of Therapeutic Radiology and Oncology, University of Virginia Medical Center, Charlottesville 22908.
authors.forename: C A
authors.initials: CA
authors.lastname: Spaulding
authors.forename: W C
authors.initials: WC
authors.lastname: Constable
authors.forename: P A
authors.initials: PA
authors.lastname: Levine
authors.forename: R W
authors.initials: RW
authors.lastname: Cantrell
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000628:therapy*; D007825:Laryngectomy; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012086:Reoperation; D012189:Retrospective Studies