title: Effect of 4-methylpyrazole on ethanol-induced decrease in rat plasma amino acids.
abstract: It has been shown earlier that an acute dose of ethanol causes an immediate decrease in the concentration of most plasma amino acids, and that this decrease involves both beta-adrenergic and adrenocortical mechanisms. In this work is shown that the oxidation of ethanol also plays an important role in the amino acid decreasing effect. Male rats were pretreated with 4-methylpyrazole, an inhibitor of liver alcohol dehydrogenase, in doses causing an 85% inhibition of the ethanol elimination. In this group the ethanol-induced decrease in amino acids was much less pronounced than in a control group pretreated with saline.
authors.affiliation: Department of Clinical Chemistry, Gothenburg University, Sahlgren's Hospital, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Hagman
authors.forename: R
authors.initials: R
authors.lastname: Jagenburg
mesh_terms: D000596:Amino Acids / Q000097:blood*; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D000077604:Fomepizole; D008297:Male; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000596:Amino Acids; D011720:Pyrazoles; D000431:Ethanol; D000077604:Fomepizole