Functional muscarinic supersensitivity in denervated rat hippocampus.
The effects of carbachol (CCh), a cholinergic agonist, were compared in voltage-clamped hippocampal pyramidal neurons in vitro, obtained from normal and fimbria-fornix-lesioned rats. A substantial increase in sensitivity to the effects of CCh was seen in denervated neurons. The supersensitivity was demonstrated on both the inward leak current and the calcium-dependent potassium current, IAHP. These findings provide convincing evidence for cholinergic denervation supersensitivity in the hippocampus.
Benson
D M
DM
Department of Psychiatry and Pharmacology, Mt. Sinai School of Medicine, Bronx, NY.
Blitzer
R D
RD
Haroutunian
V
V
Landau
E M
EM
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D066298:In Vitro Techniques; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology
D011976:Receptors, Muscarinic; D002217:Carbachol; D000110:Acetylcholinesterase