title: Intravenous clonidine hydrochloride toxicity in pregnant ewes.
abstract: Administration of intravenous clonidine hydrochloride has been advocated to rapidly control blood pressure in severe preeclampsia. To examine clonidine's acute maternal and fetal effects were intravenously injected 300 micrograms clonidine in eight chronically prepared normotensive near term ewes. Unlike intravenous saline solution injection, clonidine produced significant toxicity--intraamniotic pressure increased 97 +/- 27% (p less than 0.05), uterine blood flow decreased 55 +/- 7% (p less than 0.001), maternal and fetal serum glucose increased 158 +/- 23% and 249 +/- 91%, respectively (p less than 0.001), and maternal and fetal Po2 decreased to 44 mm Hg +/- 4 mm Hg and 13 mm Hg +/- 1 mm Hg, respectively (p less than 0.05). Maternal and fetal blood pressure and serum cortisol were unaffected by clonidine, whereas heart rate decreased. No adverse maternal or fetal effects were noted with serum clonidine concentrations less than 1.0 ng/ml. Direct fetal infusion of clonidine did not lower fetal arterial Po2 levels, although heart rates decreased and serum glucose levels increased. The multiple effects of clonidine infusion are best explained by actions on alpha 2-adrenergic receptors. These results suggest that intravenous administration of clonidine may adversely affect the fetus by direct actions and by alterations in maternal physiology.
authors.affiliation: Department of Anesthesia, Wake Forest University, Bowman Gray School of Medicine, Winston-Salem, NC 27103.
authors.forename: J C
authors.initials: JC
authors.lastname: Eisenach
authors.forename: M I
authors.initials: MI
authors.lastname: Castro
authors.forename: D M
authors.initials: DM
authors.lastname: Dewan
authors.forename: J C
authors.initials: JC
authors.lastname: Rose
authors.forename: S C
authors.initials: SC
authors.lastname: Grice
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003000:Clonidine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006339:Heart Rate / Q000187:drug effects; D006340:Heart Rate, Fetal / Q000187:drug effects; D006854:Hydrocortisone / Q000097:blood; D007275:Injections, Intravenous; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood / Q000187:drug effects* / Q000502:physiology; D012039:Regional Blood Flow / Q000187:drug effects; D012756:Sheep; D014599:Uterus / Q000098:blood supply / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D003000:Clonidine; D010100:Oxygen; D006854:Hydrocortisone