Ontogeny of human suppressor inducer T cell subset.
A T cell subset (T4+,2H4+) has recently been identified, which acts as an inducer of T8+ suppressor cells; however 2H4 molecules have not been detected in thymuses from normal individuals or on the surface of immature thymocyte clones. In the present study, T4+,2H4+ and T8+,2H4+ cells have been found in maternal and new-born blood samples. However, only a small percentage of 2H4+ cells were detected in human fetal thymus, bone marrow, liver and spleen, thus suggesting that T cells acquire these molecules only in circulation and at a late stage of maturation.
Adinolfi
M
M
Paediatric Research Unit, United Medical School of Guy's Hospital, London, UK.
Rodin
A
A
Cheetham
M
M
Chapman
M
M
D000911:Antibodies, Monoclonal; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D008099:Liver / Q000196:embryology* / Q000276:immunology; D011247:Pregnancy / Q000276:immunology; D013154:Spleen / Q000196:embryology* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013950:Thymus Gland / Q000196:embryology* / Q000276:immunology
D000911:Antibodies, Monoclonal