Influence of benzamide on killing and mutation of density-inhibited V79 cells by MNNG.
Density-inhibited V79 cells when held for 24 h in complete medium after exposure to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) show improved survival levels and decreased mutant frequencies at all dose levels, compared to cells not so held. However, when benzamide, an inhibitor of poly(ADP-ribose) synthesis was present during this 24-h holding, the improvement in survival and decrease in mutant frequencies were not observed. Rather, compared to the control, the cells became more sensitive to MNNG and mutant frequency also increased significantly for all doses studied.
Ghosh
R
R
Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Calcutta, India.
Bhattacharjee
S B
SB
D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003260:Contact Inhibition; D006224:Cricetinae; D004260:DNA Repair / Q000187:drug effects*; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D009154:Mutation / Q000187:drug effects*; D009702:Nucleoside Diphosphate Sugars / Q000502:physiology*; D011064:Poly Adenosine Diphosphate Ribose / Q000502:physiology*
D001549:Benzamides; D009702:Nucleoside Diphosphate Sugars; D008769:Methylnitronitrosoguanidine; D011064:Poly Adenosine Diphosphate Ribose; C037689:benzamide