[Effect of taurine on Ca, Mg-ATPase activity in human platelets and on their aggregation].
Effect of taurine (25 mM) on calcium metabolism in human platelets was studied. Ca, Mg-ATPase activity is significantly increased upon addition of 25 mM of taurine to the incubation medium. The activation is absent or reduced in the presence of trifluoroperazine and beta-alanine and after preincubation of platelets with colchicine and verapamil. The rate of ADP (3.5 X 10(-6) M)-induced platelet aggregation is reduced by half upon taurine addition to platelet-rich plasma. The possible role of taurine in intracellular calcium translocation and the following alteration of platelet activity is suggested.
Almazov
V A
VA
Gurevich
V S
VS
Mikhaĭlova
I A
IA
Strel'tsova
E N
EN
D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D013268:Stimulation, Chemical; D013654:Taurine / Q000494:pharmacology*
D013654:Taurine; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases
Vliianie taurina na aktivnost' Ca, Mg-ATFazy i agretatsiiu trombotsitov cheloveka.