Long-term changes in discharge behaviour of cat dorsal horn neurones following noxious stimulation of deep tissues.
Certain pathological types of afferent input are supposed to lead to long-term changes in the responsiveness of dorsal horn neurones. This mechanism might be of importance for the development of neurological disturbances such as chronic pain. The present study was undertaken in order to find out whether dorsal horn neurones--particularly those processing input from deep tissues--exhibit long-lasting changes in response behaviour after a short-lasting noxious stimulation of deep tissue. In anaesthetized cats, the impulse activity of single dorsal horn cells was recorded extracellularly with glass microelectrodes. In a small number of cells that had multiple receptive fields (RFs), the algesic agent bradykinin was injected into a muscle RF and the properties of all RFs retested at regular time intervals. Following noxious chemical stimulation of one RF, the injected and the other RFs of the same neurone often showed changes which consisted of an increase in size, a lowering of mechanical threshold and appearance of new RFs. In an attempt to assess the influence of a single noxious stimulus on the entire population of dorsal horn cells, the properties of a greater sample of neurones were compared before and after injection of bradykinin into the deep tissues of the hind limb. Every cell encountered was classified as being driven by (1) cutaneous receptors only, (2) deep receptors only, (3) both input sources, or (4) electrical stimulation only (cell without receptive field). Following injection of bradykinin, the proportion of cells with both deep and cutaneous input and of those having background activity rose, and the percentage of cells without a receptive field decreased.(ABSTRACT TRUNCATED AT 250 WORDS)
Hoheisel
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U
Anatomisches Institut III, Universität Heidelberg, Im Neuenheimer Feld 307, D-6900 HeidelbergF.R.G.
Mense
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S
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D002415:Cats; D004594:Electrophysiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology*; D010812:Physical Stimulation; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects / Q000503:physiopathology*; D013997:Time Factors
D001920:Bradykinin