Isolation and characterization of new antibiotics resorcinomycins A and B.
New antibiotics, resorcinomycins A and B, were isolated from the culture broth of a streptomycete strain identified as Streptoverticillium roseoverticillatum. The antibiotics are water-soluble amphoteric substances, positive to SAKAGUCHI'S reagent. The molecular formulas C14H20N4O5 and C13H18N4O5 for A and B were indicated by elemental analysis and secondary ion MS. The structures of these antibiotics were determined by 1H and 13C NMR spectrometry and some chemical evidences to be N-[(S)-alpha-guanidino-3,5-dihydroxy-4-isopropylphenylacetyl]glyci ne and N-[(S)-alpha-guanidino-3,5-dihydroxy-4-ethylphenylacetyl]-glycine, respectively.
Kondo
E
E
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Katayama
T
T
Kawamura
Y
Y
Yasuda
Y
Y
Matsumoto
K
K
Ishii
K
K
Tanimoto
T
T
Hinoo
H
H
Kato
T
T
Kyotani
H
H
D000192:Actinomycetales / Q000145:classification / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D004151:Dipeptides / Q000302:isolation & purification; D005285:Fermentation
D000900:Anti-Bacterial Agents; D004151:Dipeptides; C058734:resorcinomycin B; C058733:resorcinomycin A