Evidence of norepinephrine-mediated suppression of para-chlorophenylalanine-induced muricidal behavior.
Rats were made aggressive (muricide behavior) by p-chlorophenylalanine (p-CPA) treatment. The aggressive behavior was inhibited by the electrical stimulation of the locus coeruleus (LC) or by the administration of yohimbine (20 mg/kg i.p.). Both types of inhibition were blocked by the administration of low doses of clonidine (0.15 mg/kg i.p.). These results suggest the involvement of the adrenergic system in modulating muricidal behavior induced by p-CPA.
Puciłowski
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O
Valzelli
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D000374:Aggression / Q000187:drug effects*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D010134:Fenclonine / Q000494:pharmacology*; D008125:Locus Coeruleus / Q000502:physiology; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D015016:Yohimbine / Q000494:pharmacology
D015016:Yohimbine; D003000:Clonidine; D010134:Fenclonine; D009638:Norepinephrine