Evoked potentials, reaction time and cognitive performance in on and off phases of Parkinson's disease.
Seven patients with Parkinson's disease and severe motor fluctuations were studied with event-related potentials, reaction and movement times and neuropsychological tests while in "off" and "on" phases. While there was a significant decrement in the P300 latency of the event-related potentials and in the duration of movement time in the "on" phase, no significant differences between on and off phases were observed in reaction time and neuropsychological tasks.
Starkstein
S E
SE
Institute of Neurological Research, Dr. Paul Carrea, Buenos Aires, Argentina.
Esteguy
M
M
Berthier
M L
ML
Garcia
H
H
Leiguarda
R
R
D000368:Aged; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology*; D002540:Cerebral Cortex / Q000503:physiopathology; D003704:Dementia / Q000503:physiopathology* / Q000523:psychology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology*; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000503:physiopathology* / Q000523:psychology; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology*