Reduced atrial natriuretic factor after ligation of the left coronary artery in rats.
The diuretic-natriuretic responses of eight assay rats to extracts of atrial tissue obtained 3 months after left coronary ligation were less than the responses to extracts of tissue from sham-operated controls. The mean difference in diuresis (sham-operated response minus ligated response) was 370 (range 22 to 656) microliter/20 minutes (p less than 0.01) and in natriuresis 56 (range -92 to 222) microEq/20 minutes (p = 0.19). The differences in diuretic responses to these extracts was directly related to the severity of elevation of left ventricular end-diastolic pressure in these rats (r = -0.82, p = 0.01). These results in a model with varying degrees of left ventricular dysfunction suggest that myocardial damage is associated with a chronic decrease in atrial natriuretic factor. Reduced circulating atrial natriuretic factor therefore could contribute to the previously observed impaired ability of coronary ligated rats to excrete a saline load and to the sodium retention observed in clinical heart failure. Conclusive evidence will depend on the development of techniques to measure plasma levels of this hormone.
Rector
T S
TS
Carlyle
P F
PF
Cohn
J N
JN
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure; D001835:Body Weight; D003327:Coronary Disease / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D006321:Heart / Q000033:anatomy & histology; D008297:Male; D009318:Natriuresis; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains
D009320:Atrial Natriuretic Factor