title: phs Locus of Escherichia coli, a mutation causing pleiotropic lesions in metabolism, is an rpoA allele.
abstract: The phs mutation, which causes a pleiotropic growth defect, has been mapped and shown to be an allele of rpoA, the gene for the alpha subunit of RNA polymerase. The mutation is shown to cause a transcription defect in the arabinose operon, araBAD.
authors.forename: G C
authors.initials: GC
authors.lastname: Rowland
authors.forename: P M
authors.initials: PM
authors.lastname: Giffard
authors.forename: I R
authors.initials: IR
authors.lastname: Booth
mesh_terms: D000483:Alleles; D001089:Arabinose / Q000378:metabolism; D010582:Bacteriophage lambda / Q000235:genetics; D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial; D003090:Coliphages / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000235:genetics*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D005798:Genes, Bacterial; D005816:Genetic Complementation Test; D008242:Lysogeny; D009154:Mutation; D009876:Operon; D010641:Phenotype; D014158:Transcription, Genetic; D014161:Transduction, Genetic
chemical_list: D001089:Arabinose; D012321:DNA-Directed RNA Polymerases