title: Effect of parthenin on mitochondrial oxidative phosphorylation.
abstract: The sesquiterpene lactone, 'parthenin' the toxic principle of the allergenic weed Parthenium hysterophorus, inhibited 'state 3' respiration and stimulated 'state 4' respiration in rat liver and kidney mitochondria as well as ATPase activity in the presence of Mg2+ ions. These properties indicate that the toxic action of parthenin may be related to its interference with oxidative phosphorylation.
authors.forename: T R
authors.initials: TR
authors.lastname: Narasimhan
authors.forename: N
authors.initials: N
authors.lastname: Harindranath
authors.forename: C K
authors.initials: CK
authors.lastname: Kurup
authors.forename: P V
authors.initials: PV
authors.lastname: Rao
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D012717:Sesquiterpenes / Q000494:pharmacology*; D014475:Uncoupling Agents
chemical_list: D012717:Sesquiterpenes; D014475:Uncoupling Agents; C022097:parthenin; D000251:Adenosine Triphosphatases