Species-specific hemolysis of erythrocytes by T-2 toxin.
The tricothecene mycotoxin, T-2 toxin interacts differently with mammalian erythrocytes. Pig, man, rabbit, guinea pig, horse, dog, rat, and mouse erythrocytes are all lysed to a varying degree by T-2 toxin. But cow, sheep, goat, buffalo, and deer erythrocytes are all resistant to hemolysis by T-2 toxin. Since erythrocytes from ruminant animals contain little or no phosphatidylcholine, perhaps the presence of phosphatidylcholine in the membrane is required for the hemolytic action of T-2 toxin. Sheep erythrocytes were used to encapsulate T-2 toxin further confirming the resistance of erythrocytes from animals with ruminant physiology to T-2 toxin lysis.
DeLoach
J R
JR
U.S. Department of Agriculture, Agricultureal Research Service, College Station, Texas 77841.
Gyongyossy-Issa
M I
MI
Khachatourians
G G
GG
D000818:Animals; D004198:Disease Susceptibility; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008322:Mammals / Q000097:blood*; D010713:Phosphatidylcholines / Q000378:metabolism; D012418:Ruminants / Q000097:blood*; D012717:Sesquiterpenes / Q000633:toxicity*; D013045:Species Specificity; D013605:T-2 Toxin / Q000633:toxicity*
D010713:Phosphatidylcholines; D012717:Sesquiterpenes; D013605:T-2 Toxin