title: [Effect of treatment with psychotropic preparations on suppressor T-lymphocytes in juvenile continuously-progressing schizophrenia].
abstract: The paper deals with the effect of psychotropic drugs on blood levels of suppressive T-lymphocytes in patients with continuously progressive schizophrenia. The patients were examined three times: the first sample of blood was taken after a long psychotropic therapy, the second 3 weeks after the discontinuation of the therapy and the third one 3 weeks after the resumption of treatment. The lowest levels of suppressory T-lymphocytes (averaging 16.3%) were observed during the first examination. Following the discontinuation of therapy the content of T-suppresspors increased to 21.3% (P less than 0.001) failing, however, to reach the mean level characteristic of normal donors (25.7%). The amount of suppressory T-lymphocytes decreased again after treatment resumption. It is concluded that one of the factors contributing to changes in the immunological status in patients with juvenile continuously progressive schizophrenia may be a long-term use of psychotropic drugs.
authors.forename: T V
authors.initials: TV
authors.lastname: Mikheeva
authors.forename: V V
authors.initials: VV
authors.lastname: Zemskova
authors.forename: T P
authors.initials: TP
authors.lastname: Sekirina
authors.forename: L I
authors.initials: LI
authors.lastname: Abramova
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000009:adverse effects*; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory
chemical_list: D011619:Psychotropic Drugs
vernacular_title: Vliianie lecheniia psikhotropnymi preparatami na supressornye T-limfotsity pri iunosheskoĭ nepreryvnotekushcheĭ shizofrenii.