title: Assessment of the glucose tolerance test in unselected pregnancy using 75 g glucose load.
abstract: A 75 g oral glucose tolerance test (OGTT) was performed in 618 unselected pregnant Chinese women between 24 and 28 weeks gestation. The glucose response at fasting, 1, 2 and 3 h were studied. At 2 h the glucose level at 2-standard deviation and 4-standard deviation above the mean came very close to the criteria of abnormality suggested by the World Health Organization (WHO): 8.3 mmol/l vs. 8.0 mmol/l for impaired glucose tolerance and 10.8 mmol/l vs. 11.0 mmol/l for gestational diabetes mellitus. The area under the glucose response curve also correlates best with the glucose levels at 2 h during the OGTT (y = 2.1x + 4.6, r = 0.885). The 75-g OGTT interpreted with the WHO criteria seems appropriate for pregnant Chinese women. The 75-g test has the added advantages of reducing administration cost and discomfort of the patients.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Hong Kong.
authors.forename: D F
authors.initials: DF
authors.lastname: Li
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Wang
authors.forename: V C
authors.initials: VC
authors.lastname: Wong
authors.forename: H K
authors.initials: HK
authors.lastname: Ma
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000175:diagnosis*; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D005951:Glucose Tolerance Test / Q000379:methods*; D006801:Humans; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000175:diagnosis*; D014944:World Health Organization
chemical_list: D005947:Glucose