title: Quantitative methods for assessing a synergistic or potentiated genotoxic response.
abstract: The problem of assessing chemical interactions in studies of genotoxicity is discussed. Attention is focused on assessing possible synergism or potentiation when the observed genotoxic response is binary (yes-no). Different forms of enhancement are distinguished based upon different assumptions on the genotoxic activity of the experimental treatments. A generalized linear statistical model is considered that links the probability of the binary response to the doses, and data-analytic strategies are described for detecting synergy and potentiation in factorially designed experiments. This approach is illustrated with a series of analyses of various genotoxicity data-sets.
authors.affiliation: Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
authors.forename: W W
authors.initials: WW
authors.lastname: Piegorsch
authors.forename: B H
authors.initials: BH
authors.lastname: Margolin
mesh_terms: D000585:Aminacrine / Q000633:toxicity; D002110:Caffeine / Q000633:toxicity; D002840:Chromates / Q000633:toxicity; D004357:Drug Synergism; D006918:Hydroxyurea / Q000633:toxicity; D008954:Models, Biological; D009152:Mutagenicity Tests / Q000592:standards*; D017680:Potassium Compounds; D013223:Statistics as Topic; D014965:X-Rays
chemical_list: D002840:Chromates; D017680:Potassium Compounds; D002110:Caffeine; C027373:potassium chromate(VI); D000585:Aminacrine; D006918:Hydroxyurea