title: The ileum is the major site of absorption of vitamin B12 analogues.
abstract: Non-cobalamin vitamin B12 analogues constitute a significant percentage of total corrinoids in human serum. The source and means of absorption of analogues and their significance are largely unknown. We studied the sites of production and absorption of B12 analogues by measuring serum vitamin B12 and analogues in 93 patients with various gastrointestinal diseases: pernicious anemia (PA), ileal resections, ileitis, Crohn's colitis, ulcerative colitis, and irritable bowel syndrome (IBS). Patients with PA had normal analogue levels that were unchanged or that rose during cessation of B12 administration. Patients with IBS, Crohn's colitis, ulcerative colitis, and total colectomies had B12 analogues in the normal range. Patients with diseased or resected ileums had low B12 and analogues. These data suggest that serum B12 analogues are absorbed in the ileum by a mechanism independent of intrinsic factor, and that colonic bacteria and endogenous metabolism of vitamin B12 do not contribute significantly to their level.
authors.affiliation: Bronx Veterans Administration Medical Center, New York.
authors.forename: S
authors.initials: S
authors.lastname: Shaw
authors.forename: E
authors.initials: E
authors.lastname: Jayatilleke
authors.forename: S
authors.initials: S
authors.lastname: Meyers
authors.forename: N
authors.initials: N
authors.lastname: Colman
authors.forename: B
authors.initials: B
authors.lastname: Herzlich
authors.forename: V
authors.initials: V
authors.lastname: Herbert
mesh_terms: D000752:Anemia, Pernicious / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007079:Ileitis / Q000601:surgery; D007082:Ileum / Q000378:metabolism*; D014805:Vitamin B 12 / Q000031:analogs & derivatives / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D014805:Vitamin B 12