title: Linkage studies in X-linked Alport's syndrome.
abstract: Four kindreds segregating for Alport's syndrome (ASLN) compatible with a X-linked inheritance were studied for linkage with polymorphic markers of the human X chromosome. No recombinant was observed between the ASLN locus and the DXS101 and DXS94 loci, the maximum lod scores were z = 3.93 and 3.50 respectively. Linkage data between the ASLN locus and the other genetic markers used in the present study are in keeping with the assignment of the mutation to the proximal Xq arm.
authors.affiliation: Unité de Recherches de Génétique Médicale, INSERM U. 12, Hôpital des Enfants Malades, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Szpiro-Tapia
authors.forename: G
authors.initials: G
authors.lastname: Bobrie
authors.forename: M
authors.initials: M
authors.lastname: Guilloud-Bataille
authors.forename: S
authors.initials: S
authors.lastname: Heuertz
authors.forename: C
authors.initials: C
authors.lastname: Julier
authors.forename: J
authors.initials: J
authors.lastname: Frézal
authors.forename: J P
authors.initials: JP
authors.lastname: Grünfeld
authors.forename: M C
authors.initials: MC
authors.lastname: Hors-Cayla
mesh_terms: D000328:Adult; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009394:Nephritis, Hereditary / Q000235:genetics*; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D014960:X Chromosome
chemical_list: D005819:Genetic Markers