Extra-adrenal myelolipoma.
Extra-adrenal myelolipomas are rarely reported lesions, with only 18 cases found in the world literature. We report a series of three cases, all occurring in women in an age range of 68 to 83 years (mean, 77 years). One patient presented with a pelvic mass while the other two cases were incidental findings at autopsy. All lesions were presacral in location, encapsulated, and not attached to adjacent structures. Sizes ranged from 6 to 12 cm in greatest dimension and from 72 to 330 g. Color was a variegated yellow to red-brown. Microscopically, all were composed of mature fat and focal collections of normal hematopoietic elements. The nature of these lesions is not known but most authors favor a choristomatous origin. They must be distinguished from extramedullary hematopoietic tumors seen in patients with severe anemias, myeloproliferative disorders, and skeletal disease.
Grignon
D J
DJ
Department of Pathology, M.D. Anderson Hospital and Tumor Institute, Houston.
Shkrum
M J
MJ
Smout
M S
MS
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008067:Lipoma / Q000473:pathology*; D010386:Pelvic Neoplasms / Q000473:pathology*; D012186:Retroperitoneal Neoplasms / Q000473:pathology*