title: [Successful clonidine treatment of restless leg syndrome in chronic kidney insufficiency].
abstract: Restless legs syndrome is a common and sometimes incapacitating disorder in chronic uraemic patients. While therapeutic concepts have so far been disappointing, there have been recent reports on the favourable effect of clonidine in non-uraemic patients with symptoms of restless legs syndrome. Therefore, a double-blind study was conducted in 20 patients with chronic renal failure (11 conservatively treated, 9 on RDT) and symptoms of restless legs. 10 patients were treated with 0.075 mg clonidine twice daily and 10 received placebo. The patients were investigated 3 days after starting therapy. - In the clonidine-treated group complete relief of symptoms was noted in 8 out of 10 patients, a striking alleviation in one, while in one further patient the symptoms remained unchanged. In contrast, only one of 10 patients in the placebo group had a mild alleviation of symptoms. Blood pressure did not differ significantly in the two groups. The data show that low-dose clonidine administration is a very effective approach in the treatment of the restless legs syndrome in chronic uraemic patients.
authors.affiliation: 1. Medizinische Abteilung, Landeskrankenhaus Klagenfurt.
authors.forename: M
authors.initials: M
authors.lastname: Ausserwinkler
authors.forename: P
authors.initials: P
authors.lastname: Schmidt
mesh_terms: D000328:Adult; D000368:Aged; D003000:Clonidine / Q000627:therapeutic use*; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012148:Restless Legs Syndrome / Q000188:drug therapy* / Q000209:etiology
chemical_list: D003000:Clonidine
vernacular_title: Erfolgreiche Behandlung des "restless legs"-Syndroms bei chronischer Niereninsuffizienz mit Clonidin.