title: The nature of the Ca2+-pump defect in the red blood cells of patients with cystic fibrosis.
abstract: The reduction in (Ca2+ + Mg2+)-ATPase activity in the cystic fibrosis red blood cells can be attributed to a reduction in the number of active Ca2+ pumps per red blood cell and an altered interaction of calcium ions with the pump. Despite this, the normal free intracellular [Ca2+] is preserved due to a lower rate of passive calcium entry.
authors.forename: S
authors.initials: S
authors.lastname: Muallem
authors.forename: C
authors.initials: C
authors.lastname: Miner
authors.forename: C A
authors.initials: CA
authors.lastname: Seymour
mesh_terms: D001693:Biological Transport, Active; D017301:Ca(2+) Mg(2+)-ATPase / Q000097:blood*; D002118:Calcium / Q000097:blood*; D000252:Calcium-Transporting ATPases / Q000097:blood*; D003550:Cystic Fibrosis / Q000097:blood*; D004910:Erythrocyte Membrane / Q000201:enzymology*; D006801:Humans
chemical_list: D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D002118:Calcium