The relationship between the pharmacokinetics and pharmacodynamics of spinal opioids. Minireview based on a doctoral thesis.
Spinal opioids have been used clinically since the late seventies to treat acute, traumatic, obstetric and chronic pain. In this article the influence of the pharmacokinetics on the dynamics of intrathecal and epidural opioid administration are discussed with reference to current knowledge.
Sjöström
S
S
Department of Anesthesiology and Intensive Care, University Hospital, Uppsala, Sweden.
D000701:Analgesics, Opioid / Q000493:pharmacokinetics*; D000775:Anesthesia, Spinal; D006801:Humans
D000701:Analgesics, Opioid