A carboxy-terminus truncated analogue of angiotensin II, [Sar1]angiotensin II-(1-7)-amide, provides an entry to a new class of angiotensin II antagonists.
Bovy
P R
PR
Cardiovascular Research, G. D. Searle & Co., Chesterfield, Missouri 63198.
Trapani
A J
AJ
McMahon
E G
EG
Palomo
M
M
D000804:Angiotensin II / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors* / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D066298:In Vitro Techniques; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D012504:Saralasin / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014661:Vasoconstriction / Q000187:drug effects
D010446:Peptide Fragments; D000804:Angiotensin II; C058708:angiotensin II amide (1-7), Sar(1)-; C040420:angiotensin II, Sar(1)-Me-Tyr(4)-; D012504:Saralasin