Myrocin C, a new diterpene antitumor antibiotic from Myrothecium verrucaria. II. Physico-chemical properties and structure determination.
The structure of a new antitumor antibiotic, myrocin C, from a strain of Myrothecium verrucaria was characterized as a pentacyclic pimarane diterpene composed of a gamma-lactol group and a unique cyclopropane ring on the basis of its physico-chemical properties and spectroscopic data as well as a single-crystal X-ray diffraction analysis of its monoacetyl derivative.
Hsu
Y H
YH
Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture, Japan.
Hirota
A
A
Shima
S
S
Nakagawa
M
M
Adachi
T
T
Nozaki
H
H
Nakayama
M
M
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification*; D004224:Diterpenes / Q000302:isolation & purification; D005658:Fungi / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012988:Soil Microbiology; D013053:Spectrophotometry; D014961:X-Ray Diffraction
D000903:Antibiotics, Antineoplastic; D004224:Diterpenes; C058997:myrocin C