A case of mucinous cystadenocarcinoma of the ovary associated with virilization: pre and post-operative steroid plasma levels.
A premenopausal woman with a mucinous carcinoma of one ovary, and a mucinous adenoma of the other, together with secondary virilization, is reported. Preoperative levels of androstenedione, testosterone and dehydroepiandrosterone sulphate were high, suggesting the presence of a virilizing tumor. Preoperative plasma estrone (E1), but not estradiol (E2), was elevated along with inversion of the E2/E1 ratio, suggesting a peripheral origin of the estrogens. FSH and LH plasma concentrations were low. After bilateral ovariectomy, levels of all steroids measured significantly decreased and gonadotropins rose to the postmenopausal range.
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D000236:Adenoma / Q000097:blood / Q000150:complications* / Q000601:surgery; D000328:Adult; D000728:Androgens / Q000097:blood; D000735:Androstenedione / Q000097:blood; D006063:Chorionic Gonadotropin / Q000097:blood; D003536:Cystadenocarcinoma / Q000097:blood / Q000150:complications* / Q000601:surgery; D003687:Dehydroepiandrosterone / Q000097:blood; D004967:Estrogens / Q000097:blood; D005260:Female; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications* / Q000601:surgery; D010052:Ovariectomy; D011374:Progesterone / Q000097:blood; D013739:Testosterone / Q000097:blood; D013997:Time Factors; D014770:Virilism / Q000097:blood / Q000209:etiology*
D000728:Androgens; D006063:Chorionic Gonadotropin; D004967:Estrogens; D006065:Gonadotropins, Pituitary; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D011374:Progesterone