title: CR1-expression and C3b-mediated phagocytosis of granulocytes in purulent maxillary secretion and peripheral blood from patients with sinusitis.
abstract: Granulocytes in sinus pus and in peripheral blood in 28 patients with maxillary sinus empyema were compared to blood granulocytes obtained from healthy blood donors. A flow cytofluorometric assay technique was used to establish the C3b-mediated phagocytosis and the CR1-receptor expression. The results indicate that a subpopulation of viable granulocytes in situ was activated with an increased ability to ingest particles. From 11 of 28 patients, an increased CR1-expression was also demonstrated in the blood samples, reflecting a priming of the circulating granulocytes before extravasation.
authors.affiliation: Department of Otolaryngology, Karolinska Hospital, Stockholm, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Berg
authors.forename: C
authors.initials: C
authors.lastname: Carenfelt
authors.forename: G
authors.initials: G
authors.lastname: Halldén
authors.forename: J
authors.initials: J
authors.lastname: Hed
mesh_terms: D000328:Adult; D003179:Complement C3b / Q000502:physiology*; D006098:Granulocytes / Q000502:physiology*; D006801:Humans; D008443:Maxillary Sinus / Q000378:metabolism*; D010587:Phagocytosis; D011951:Receptors, Complement / Q000378:metabolism*; D012852:Sinusitis / Q000097:blood / Q000503:physiopathology*; D013492:Suppuration
chemical_list: D011951:Receptors, Complement; D003179:Complement C3b