Beta-adrenergic induction of a cysteine-proteinase-inhibitor mRNA in rat salivary glands.
Transcripts encoding the cysteine-proteinase inhibitor rat cystatin S are induced in submandibular and parotid glands by the beta-adrenergic agonist isoproterenol (isoprenaline). High levels of cystatin S mRNA persist in glands of chronically treated animals for 6 days after discontinuation of the catecholamine, indicating a long half-life of the mRNA. Post-transcriptionally the size of the mRNA decreases, owing to a shortening of the poly(A) tail.
Shaw
P A
PA
Department of Anatomy, Mount Sinai School of Medicine, New York, NY 10029.
Barka
T
T
D000818:Animals; D015152:Blotting, Northern; D015891:Cystatins; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D055333:Salivary Cystatins; D012469:Salivary Glands / Q000187:drug effects; D012471:Salivary Proteins and Peptides / Q000378:metabolism*
C525174:Cyss protein, rat; D015891:Cystatins; D011480:Protease Inhibitors; D012333:RNA, Messenger; D055333:Salivary Cystatins; D012471:Salivary Proteins and Peptides; D007545:Isoproterenol