title: Human immunodeficiency virus seroprevalence among blood product recipients in San Francisco before transfusion.
abstract: To determine the incidence of transfusion-associated human immunodeficiency virus (HIV) infection after routine screening of donated blood, a pilot study estimated the pretransfusion prevalence of HIV infection among blood product recipients in San Francisco. Among the 911 nonduplicate pretransfusion specimens from recipients without a clinical history of acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC), the overall prevalence of antibody to HIV was 2.9 percent (5.2% among males and 0.6% among females; p = 0.00002). If recipients in specifically defined or possible high-risk groups (n = 348) were excluded, a seropositivity rate of 1.8 percent (10/563) was detected, with all the positives occurring in men (10/242, 4.1%) and none in women (0/321, 0%). This demonstrated prevalence of HIV infection among blood product recipients in San Francisco before transfusion was substantially higher than the known 0.02 to 0.04 percent prevalence in the donor population. Therefore, the population of women without known risk for AIDS is the best in which to assess the risk of HIV infection in patients who are currently receiving seronegative blood transfusions.
authors.affiliation: School of Public Health, University of Texas Health Sciences Center, Houston.
authors.forename: L Y
authors.initials: LY
authors.lastname: Hwang
authors.forename: R P
authors.initials: RP
authors.lastname: Beasley
authors.forename: M P
authors.initials: MP
authors.lastname: Busch
authors.forename: P K
authors.initials: PK
authors.lastname: Lane
authors.forename: G N
authors.initials: GN
authors.lastname: Vyas
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001800:Blood Specimen Collection; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D005069:Evaluation Studies as Topic; D005260:Female; D015483:HIV Antibodies / Q000032:analysis*; D006679:HIV Seropositivity / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012015:Reference Standards; D012307:Risk Factors; D012495:San Francisco; D012737:Sex Factors; D013997:Time Factors
chemical_list: D015483:HIV Antibodies