title: Recurrent diabetes insipidus associated with pregnancy: pathophysiology and therapy.
abstract: Diabetes insipidus during pregnancy is an uncommon medical problem. We present a woman who developed transient central diabetes insipidus during two successive pregnancies. A water deprivation study with plasma arginine vasopressin concentrations confirmed the diagnosis and established the efficacy of 1-desamino-8-d-arginine-vasopressin (dDAVP). The patient was then successfully and safely treated through the second pregnancy with dDAVP.
authors.affiliation: Department of Internal Medicine, University of Virginia Medical Center, Charlottesville.
authors.forename: J M
authors.initials: JM
authors.lastname: Hughes
authors.forename: W M
authors.initials: WM
authors.lastname: Barron
authors.forename: M L
authors.initials: ML
authors.lastname: Vance
mesh_terms: D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D003919:Diabetes Insipidus / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006801:Humans; D009994:Osmolar Concentration; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000503:physiopathology; D012008:Recurrence; D014868:Water Deprivation; D014882:Water-Electrolyte Balance
chemical_list: D001127:Arginine Vasopressin; D003894:Deamino Arginine Vasopressin