The heterogeneity and differential expression of protein kinase C in nervous tissues.
Protein kinase C exists as a large family of multiple subspecies with subtle individual characteristics. This heterogeneity comes from different genes as well as from different splicings of a single RNA transcript. The members of this family have closely related structures with a high degree of homology. Biochemical studies have shown that their mode of activation and kinetic and catalytic properties differ slightly from one another. By using a combination of biochemical and immunocytochemical techniques, their differential regional and cellular expression have been shown in the nervous tissues. Each member of this enzyme family may have a specialized function in transducing various physiological and pathological signals into different cell types.
Kikkawa
U
U
Department of Biochemistry, Kobe University School of Medicine, Japan.
Ogita
K
K
Shearman
M S
MS
Ase
K
K
Sekiguchi
K
K
Naor
Z
Z
Ido
M
M
Nishizuka
Y
Y
Saito
N
N
Tanaka
C
C
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000201:enzymology*; D007700:Kinetics; D008969:Molecular Sequence Data; D009420:Nervous System / Q000201:enzymology*; D011493:Protein Kinase C / Q000235:genetics* / Q000378:metabolism
D011493:Protein Kinase C