Variables of patient-controlled analgesia. 1. Bolus size.
The efficacy of a range of demand doses of morphine for patient-controlled analgesia was studied. Patients who self-administered the smallest dose (0.5 mg) were frequently unable to achieve good pain control; patients who received the largest dose (2 mg) had a high incidence of ventilatory depression. A dose of 1 mg was the best increment under the conditions of this study but the relationship between increment and lockout interval requires consideration.
Owen
H
H
Department of Anaesthesia and Intensive Care Flinders University of South Australia, Bedford Park.
Plummer
J L
JL
Armstrong
I
I
Mather
L E
LE
Cousins
M J
MJ
D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*; D011897:Random Allocation; D012646:Self Administration
D009020:Morphine