Examination of the interaction of decis and dithane in rats.
Acute (LD50) and short-term (14 days) toxicological examinations were performed in animal experiments on the interaction of a synthetic pyrethroid Decis 2,5 EC (25 g deltamethrin/l) and of ethylene-bisdithiocarbamate/Dithane M-45 (80% mancozeb), using a 1:5 deltamethrin/mancozeb mixture. LD50 value of the mixture was similar to that of the more toxic Decis. In the short-term examination, some pathologically high AST and ALT values were observed in the treated groups and the deltamethrin content of fatty tissue samples increased parallel with the increase of Decis consumption. The chymotrypsin and lipase activities in the small intestinal mucosa and gamma-GT and LAP activities in the content of the bowels were reduced in several treated groups. The administration of Dithane in a dose in accordance with 20% of the LD50 value (3125 mg/kg b.m.) proved to be more toxic than expected and caused the death of the animals.
Szépvölgyi
J
J
National Institut of Food Hygiene and Nutrition, Budapest, Hungary.
Nagy
K
K
Bedó
M
M
Regöly-Mérei
A
A
Szerletics
M
M
Soós
K
K
Antal
M
M
D000273:Adipose Tissue / Q000378:metabolism; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002918:Chymotrypsin / Q000037:antagonists & inhibitors; D004032:Diet; D004347:Drug Interactions; D007413:Intestinal Mucosa / Q000201:enzymology; D007928:Lethal Dose 50; D007931:Leucyl Aminopeptidase / Q000037:antagonists & inhibitors; D008049:Lipase / Q000037:antagonists & inhibitors; D008297:Male; D008344:Maneb / Q000031:analogs & derivatives / Q000378:metabolism / Q000633:toxicity*; D009570:Nitriles; D011722:Pyrethrins / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013859:Thiocarbamates / Q000633:toxicity*; D015038:Zineb / Q000031:analogs & derivatives / Q000378:metabolism / Q000633:toxicity*; D005723:gamma-Glutamyltransferase / Q000037:antagonists & inhibitors
D009570:Nitriles; D011722:Pyrethrins; D013859:Thiocarbamates; D008344:Maneb; C017180:decamethrin; C011453:dithane M-45; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D008049:Lipase; D007931:Leucyl Aminopeptidase; D002918:Chymotrypsin; D015038:Zineb