title: Visual contrast sensitivity in drug-induced Parkinsonism.
abstract: The influence of stimulus orientation on contrast sensitivity function was studied in 10 patients with drug-induced Parkinsonism. Nine of the 10 patients had at least one eye with contrast sensitivity deficit for vertical and/or horizontal stimuli. Only generalised contrast sensitivity loss, observed in two eyes, was stimulus orientation independent. All spatial frequency-selective contrast deficits in 15 eyes were orientation dependent. The striking similarity between the pattern of contrast sensitivity loss in drug-induced Parkinsonism and that in idiopathic Parkinson's disease, suggests that generalised dopaminergic deficiency, from whatever cause, affects visual function in an analogous way.
authors.affiliation: Department of Neurology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Bulens
authors.forename: J D
authors.initials: JD
authors.lastname: Meerwaldt
authors.forename: G J
authors.initials: GJ
authors.lastname: van der Wildt
authors.forename: C J
authors.initials: CJ
authors.lastname: Keemink
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy; D003866:Depressive Disorder / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D005484:Fluspirilene / Q000009:adverse effects* / Q000627:therapeutic use; D006220:Haloperidol / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009949:Orientation / Q000187:drug effects; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D010364:Pattern Recognition, Visual / Q000187:drug effects; D011247:Pregnancy; D011618:Psychotic Disorders / Q000188:drug therapy*; D011644:Puerperal Disorders / Q000188:drug therapy; D012559:Schizophrenia / Q000188:drug therapy; D012684:Sensory Thresholds / Q000187:drug effects; D013141:Spiro Compounds / Q000009:adverse effects*; D014796:Visual Perception / Q000187:drug effects*
chemical_list: D013141:Spiro Compounds; D005484:Fluspirilene; D006220:Haloperidol