[Carnosine prevents the activation of free-radical lipid oxidation during stress].
Carnosine (beta-alanyl-L-histidine) injected to intact albino rats (20 mg/kg body weight) induces depletion of lipid peroxidation (LPO) products in brain and blood serum, an increase of superoxide scavenging activity in brain and serum, decrease of cholesterol: phospholipid ratio and increase of easy oxidizable phospholipid portion in brain lipid extracts. After painful stress (footshock during 2 hours) LPO products are accumulated in brain and serum, cholesterol: phospholipid ratio increases and the portion of easy oxidizable phospholipids decreases. Carnosine given before stress prevents LPO activation. Effects of carnosine and stress are not additive: LPO inhibition induced by carnosine is much more in rats subjected to stress.
Guliaeva
N V
NV
Dupin
A M
AM
Levshina
I P
IP
Obidin
A B
AB
Boldyrev
A A
AA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002336:Carnosine / Q000627:therapeutic use*; D004151:Dipeptides / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000032:analysis; D008297:Male; D051381:Rats; D013312:Stress, Physiological / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism
D004151:Dipeptides; D005609:Free Radicals; D008055:Lipids; D002336:Carnosine
Karnozin predotvrashchaet aktivatsiiu svobodnoradikal'nogo okisleniia lipidov pri stresse.