title: Recurrent parotid gland enlargement as an initial manifestation of Sjögren syndrome in children.
abstract: Recurrent parotid gland enlargement is a common disorder in children, while that of auto-immune aetiology is rare. Three children with recurrent parotid swelling had autoantibodies including antinuclear antibody, anti-SS-A (Sjögren syndrome-A), SS-B (Sjögren syndrome-B) antibodies and rheumatoid factor, abnormal sialograms and lymphocytic infiltration of salivary glands, which were consistent with Sjögren syndrome. Initially, all three lacked symptoms of keratoconjunctivitis sicca. During follow up, two patients developed xerostomia and were diagnosed as having primary Sjögren syndrome. Recurrent parotid enlargement appears to be important as an initial manifestation of Sjögren syndrome in children.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, Kyushu University, Fukuoka City, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuno
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: K
authors.initials: K
authors.lastname: Hatae
authors.forename: T
authors.initials: T
authors.lastname: Hirano
authors.forename: K
authors.initials: K
authors.lastname: Ueda
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Mizoguchi
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D010306:Parotid Gland / Q000473:pathology*; D012008:Recurrence; D012470:Salivary Glands, Minor / Q000473:pathology; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000473:pathology*