Diazepam mixed micelle--comparison with diazepam in propylene glycol and midazolam.
A mixed micelle formulation of diazepam was compared with midazolam and diazepam in propylene glycol for evidence of venous intolerance following IV injection. The overall incidence of venous morbidity was 17% for diazepam mixed micelle, 26% for midazolam and 90% for diazepam in propylene glycol. Diazepam mixed micelle is suggested as a preferable alternative to the standard formulation.
Galletly
D C
DC
Wilson
L F
LF
Treuren
B C
BC
Boon
B P
BP
D001569:Benzodiazepines / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D003975:Diazepam / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008823:Micelles; D008874:Midazolam; D010146:Pain / Q000209:etiology; D014677:Pharmaceutical Vehicles; D011409:Propylene Glycols; D013927:Thrombosis / Q000139:chemically induced; D014680:Veins / Q000187:drug effects
D008823:Micelles; D014677:Pharmaceutical Vehicles; D011409:Propylene Glycols; D001569:Benzodiazepines; D003975:Diazepam; D008874:Midazolam