title: Calcium and olfactory transduction.
abstract: 1. Inorganic cations, organic calcium antagonists, and calmodulin antagonists were applied to olfactory epithelia of frogs (Rana pipiens) while recording electroolfactogram (EOG) responses. 2. Inorganic cations inhibited EOGs in a rank order, reflecting their calcium channel blocking potency: La3+ greater than Zn2+ greater than Cd2+ greater than Al3+ greater than Ca2+ greater than Sr2+ greater than Co2+ greater than Ba2+ greater than Mg2+. Barium ion significantly enhanced EOGs immediately following application. 3. Diltiazem and verapamil produced dose-dependent EOG inhibition. 4. Calmodulin antagonists inhibited EOGs without correlation to their anti-calmodulin potency.
authors.affiliation: Department of Biological Sciences, University of North Texas, Denton 76203-5218.
authors.forename: B D
authors.initials: BD
authors.lastname: Winegar
authors.forename: E R
authors.initials: ER
authors.lastname: Rosick
authors.forename: R
authors.initials: R
authors.lastname: Schafer
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002147:Calmodulin / Q000037:antagonists & inhibitors; D002412:Cations / Q000494:pharmacology; D004594:Electrophysiology; D009831:Olfactory Mucosa / Q000187:drug effects / Q000502:physiology*; D011894:Rana pipiens
chemical_list: D002121:Calcium Channel Blockers; D002147:Calmodulin; D002412:Cations; D002118:Calcium