title: Effect of etodolac in patients with moderate renal impairment compared with normal subjects.
abstract: Twenty subjects (10 with normal renal function and 10 with moderate renal insufficiency) participated in an 8-day study to assess the effects of acute and chronic etodolac dosing on renal function. Subjects and patients were hospitalized and followed a controlled diet (150 mEq sodium, 60 to 80 mEq potassium) during the study. A 3-day drug-free period was followed by 4 days of etodolac, 200 mg b.i.d. Sodium balance and body weight remained unchanged in both groups. Modest reductions in renal function as measured by clearances of inulin and p-aminohippurate occurred acutely only in the patients with renal impairment. Chronic therapy resulted in no decrements in daily creatinine clearance. In an average effective anti-inflammatory dose, etodolac did not produce a sustained effect on renal function in either normal subjects or patients with moderate renal insufficiency.
authors.forename: D C
authors.initials: DC
authors.lastname: Brater
authors.forename: S A
authors.initials: SA
authors.lastname: Anderson
authors.forename: D
authors.initials: D
authors.lastname: Brown-Cartwright
authors.forename: R D
authors.initials: RD
authors.lastname: Toto
authors.forename: A
authors.initials: A
authors.lastname: Chen
authors.forename: G B
authors.initials: GB
authors.lastname: Jacob
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002712:Chlorides / Q000652:urine; D003404:Creatinine / Q000097:blood; D004341:Drug Evaluation; D017308:Etodolac; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000652:urine
chemical_list: D000085:Acetates; D002712:Chlorides; D017308:Etodolac; D012964:Sodium; D003404:Creatinine; D011188:Potassium