title: Intestinal permeability assessed with different-sized polyethylene glycols in children undergoing small-intestinal biopsy for suspected celiac disease.
abstract: The gastrointestinal permeability was assessed by means of an oral load of a mixture of different-sized polyethylene glycols (PEG 400 and PEG 1000) in 76 children undergoing small-intestinal biopsy because of suspected celiac disease. Children with a mucosal abnormality suggestive of celiac disease had a lower urinary recovery of larger PEG molecules. They also displayed an altered permeability barrier, as evidenced by a lower ratio of recovery between large (1074 Da) and small (370 Da) PEG molecules. Gluten elimination and gluten challenge caused a significant change in PEG recoveries in children undergoing repeated PEG tests. Repeated assessments of intestinal permeability by means of different-sized PEGs after gluten withdrawal and challenge could complement or indicate suitable time for performing small-intestinal biopsy in children with gluten intolerance.
authors.affiliation: Dept. of Pediatrics, University of Linköping, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Fälth-Magnusson
authors.forename: G
authors.initials: G
authors.lastname: Jansson
authors.forename: L
authors.initials: L
authors.lastname: Stenhammar
authors.forename: T
authors.initials: T
authors.lastname: Sundqvist
authors.forename: K E
authors.initials: KE
authors.lastname: Magnusson
mesh_terms: D000293:Adolescent; D002446:Celiac Disease / Q000175:diagnosis* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D007421:Intestine, Small / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008970:Molecular Weight; D010539:Permeability; D011092:Polyethylene Glycols
chemical_list: D011092:Polyethylene Glycols; D005983:Glutens