Rectosigmoid motility response to sham feeding in irritable bowel syndrome. Evidence of a cephalic phase.
Rectosigmoid pressure recordings by means of open-ended perfused catheters were performed on 21 patients with the irritable bowel syndrome (IBS). Motility indexes were calculated in resting conditions, after sham feeding, after a meal, and after 0.5 mg neostigmine intravenously. Each step of stimulation caused a significantly increased motility index compared with the previous step (p less than 0.01). The increase in rectosigmoid pressure activity after sham feeding indicates the existence of a cephalic phase in the postprandial motor response of the colon in IBS.
Jepsen
J M
JM
Surgical Dept. I, University Hospital, Arhus Amtssygehus, Denmark.
Skoubo-Kristensen
E
E
Elsborg
L
L
D000328:Adult; D000368:Aged; D012809:Colon, Sigmoid / Q000503:physiopathology*; D003109:Colonic Diseases, Functional / Q000503:physiopathology*; D005260:Female; D005502:Food; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009388:Neostigmine / Q000008:administration & dosage*; D012007:Rectum / Q000503:physiopathology*
D009388:Neostigmine