title: Structure activity relationships of anxiolytics.
abstract: Several strikingly different classes of compound bind at the benzodiazepine receptor and exhibit an anxiolytic profile. The conformational preferences of these compounds were ascertained by a variety of techniques. Their electrostatic features were also studied. The combined information has been utilised in the development of a receptor model for the binding site.
authors.affiliation: Department of Medicinal Chemistry, Victoria College of Pharmacy, Parkville, Australia.
authors.forename: M G
authors.initials: MG
authors.lastname: Wong
mesh_terms: D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004563:Electrochemistry; D008956:Models, Chemical; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines