title: Interstrain restriction fragment length polymorphism of c-fos and c-src oncogene loci in spontaneously hypertensive and normotensive rats.
abstract: Interstrain restriction fragment length polymorphism was detected after Southern blot hybridization of spontaneously hypertensive (SHR) and control (WKY) rat DNA digested by Bam HI restrictase with a v-fos probe. The SHR genome was characterized by an additional minor band of 4.0 kb. Other restriction fragment length polymorphism was revealed in the c-src locus by Eco RI, Hind III and Pst I restrictases. The major characteristic bands were 1.6 kb (SHR) and 2.4 kb (WKY) after Eco RI restriction; 3.4 kb (SHR) and 4.1 kb (WKY) after Hind III restriction and 4.0 kb (SHR) and 4.6 kb (WKY) after Pst I restriction. This restriction fragment length polymorphism can be used as Mendelian traits in linkage studies on the distribution of blood pressure and other quantitative physiological traits in (SHR x WKY)F2 hybrids.
authors.affiliation: Central Research Laboratory, Ministry of Public Health of the USSR, Moscow.
authors.forename: Y V
authors.initials: YV
authors.lastname: Kotelevtsev
authors.forename: D A
authors.initials: DA
authors.lastname: Brashishkite
authors.forename: D D
authors.initials: DD
authors.lastname: Spitkovski
authors.forename: F L
authors.initials: FL
authors.lastname: Kiselev
authors.forename: Y V
authors.initials: YV
authors.lastname: Postnov
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics*; D008040:Genetic Linkage; D006973:Hypertension / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011519:Proto-Oncogenes; D051381:Rats; D011918:Rats, Inbred SHR / Q000235:genetics*; D011919:Rats, Inbred Strains / Q000235:genetics*; D011921:Rats, Inbred WKY
chemical_list: D004247:DNA