title: Localization of the X-linked retinitis pigmentosa locus between DXS7 and DXS84 in a family showing tapetal reflex in heterozygotes.
abstract: The linkage relationships between the X-linked retinitis pigmentosa (XLRP) locus and seven Xp loci: DXS14, DXS7, OTC, DXS141, DXS148, DXS84 and DXS206 were analysed in one large family in which the heterozygotes exhibited the tapetal reflex. Evidence drawn from two-point and multipoint linkage analysis and a number of triply informative crossovers suggests that the XLRP locus in this family is between DXS7 and DXS84. The putative order of loci on the short arm of the X chromosome is: centromere - DXS14 - DXS7 - OTC - XLRP/DXS141 - DXS148 - DXS84 - DXS206 - telemere.
authors.affiliation: Department of Clinical Chemistry, Prince of Wales Hospital, Randwick, NSW, Australia.
authors.forename: J D
authors.initials: JD
authors.lastname: Chen
authors.forename: F
authors.initials: F
authors.lastname: Halliday
authors.forename: S
authors.initials: S
authors.lastname: Serravalle
authors.forename: M
authors.initials: M
authors.lastname: Denton
mesh_terms: D002648:Child; D002874:Chromosome Mapping; D015342:DNA Probes; D008040:Genetic Linkage; D006579:Heterozygote; D006801:Humans; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D012174:Retinitis Pigmentosa / Q000235:genetics*; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014960:X Chromosome
chemical_list: D015342:DNA Probes