title: Stroke in patients with fusiform vertebrobasilar aneurysms.
abstract: We studied seven patients with brainstem infarction and large fusiform vertebrobasilar (VB) aneurysms to clarify the clinical, radiologic, and pathologic features. All presented with pontine infarcts; one also had a cerebellar infarct. VB TIAs preceded brainstem infarction in four patients. Angiography and CT documented VB fusiform aneurysmal dilatation. Four had intraluminal thrombi and one had severe basilar artery stenosis. Two distinct clinical pictures emerged: unilateral pontine infarcts with favorable outcome, presumably related to obstruction of a pontine penetrating artery at its origin from the posterior wall of the aneurysmal basilar artery, and major fatal bilateral pontine infarcts from basilar artery occlusion. Two patients came to autopsy. One had thrombus in the dilated basilar artery and a posterior cerebral artery branch embolus with hemorrhagic occipital infarction; the other had basilar artery thrombus with aneurysmal rupture and subarachnoid hemorrhage. Fusiform VB aneurysms caused brainstem stroke by intraluminal thrombus, local embolism, atherostenosis, and obstruction of paramedian penetrating arteries. Subarachnoid hemorrhage is an uncommon complication.
authors.affiliation: Department of Neurology, New England Medical Center, Boston, MA 02111.
authors.forename: M S
authors.initials: MS
authors.lastname: Pessin
authors.forename: M I
authors.initials: MI
authors.lastname: Chimowitz
authors.forename: S R
authors.initials: SR
authors.lastname: Levine
authors.forename: E S
authors.initials: ES
authors.lastname: Kwan
authors.forename: L S
authors.initials: LS
authors.lastname: Adelman
authors.forename: M P
authors.initials: MP
authors.lastname: Earnest
authors.forename: D M
authors.initials: DM
authors.lastname: Clark
authors.forename: J
authors.initials: J
authors.lastname: Chason
authors.forename: J I
authors.initials: JI
authors.lastname: Ausman
authors.forename: L R
authors.initials: LR
authors.lastname: Caplan
mesh_terms: D000328:Adult; D000368:Aged; D001488:Basilar Artery / Q000000981:diagnostic imaging / Q000473:pathology; D001921:Brain / Q000473:pathology; D002533:Cerebral Angiography; D002561:Cerebrovascular Disorders / Q000150:complications / Q000209:etiology*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014711:Vertebral Artery / Q000000981:diagnostic imaging / Q000473:pathology