Computer-assisted predictive mathematical relationship among electroshock voltage and duration and occurrence of convulsion in mice.
A microcomputer program in BASIC for predicting percentage of occurrence of electroshock-induced convulsion in mice was designed. A formula published by the author to express the mathematical relationship among the drug dose, the time, and the biological response was used in this program. Analysis of the actual, and the computer-assisted predicted percentages of occurrence of convulsion has shown that the program is fairly accurate in expressing convulsion response of mice as a function of the voltage and the duration.
Chung
S J
SJ
Department of Pathology, Morristown-Hamblen Hospital, TN 37814.
D000818:Animals; D003198:Computer Simulation; D004597:Electroshock; D005795:Generalization, Stimulus; D051379:Mice; D008838:Microcomputers; D011237:Predictive Value of Tests; D011381:Programming Languages; D012640:Seizures / Q000503:physiopathology*; D013997:Time Factors