title: Depression of calcium current at mouse motor nerve endings by polycationic antibiotics.
abstract: The hypothesis according to which polycationic antibiotics produce neuromuscular block by interfering with the Ca current of motor nerve terminals has been examined using external electrodes in nerve-muscle preparations of the mouse. It was found that kanamycin, bekanamycin and polymyxin B depressed presynaptic Ca currents probably by neutralizing negative surface charges.
authors.affiliation: Unité de Physiologie Neuromusculaire, C.N.R.S., Gif-sur-Yvette, France.
authors.forename: C
authors.initials: C
authors.lastname: Bourret
authors.forename: A
authors.initials: A
authors.lastname: Mallart
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002118:Calcium / Q000502:physiology*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D007612:Kanamycin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D013757:Tetraethylammonium Compounds; C001495:bekanamycin; D007612:Kanamycin; D002118:Calcium