Enhancement of adenosine-induced relaxant responses of the guinea-pig isolated taenia coli and aortae by a novel nootropic agent BY-1949: comparison with dipyridamole.
In muscle strips of guinea-pig taenia coli and aortae, the effects of 3-methoxy-11-methyldibenz[b,f][1,4]oxazepine-8-carboxylate (BY-1949) on the relaxant response to adenosine have been compared with those of dipyridamole. BY-1949 (3 x 10(-5)-10(-4) M) as well as dipyridamole (3 x 10(-7)-10(-5) M) resulted in a significant potentiation of relaxant responses to a cumulative administration of adenosine (10(-6)-10(-3) M), but the drugs did not affect the response to noradrenaline and acetylcholine. The results indicate that BY-1949 exerts a selective potentiating effect on reactivity to exogenous adenosine.
Tanabe
S
S
Department of Pharmacology, Chugai Pharmaceutical Co., Ltd., Shizuoka, Japan.
Ikeda
Y
Y
Shiraki
Y
Y
Sakai
K
K
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D003106:Colon / Q000187:drug effects; D003989:Dibenzoxazepines / Q000494:pharmacology*; D004176:Dipyridamole / Q000494:pharmacology*; D004357:Drug Synergism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology
D003989:Dibenzoxazepines; D004176:Dipyridamole; C058844:3-methoxy-11-methyldibenz(b,f)oxazepine-8-carboxylate; D010208:Papaverine; D000241:Adenosine; D009638:Norepinephrine