[Aerobic and anaerobic capacity of chronic hemodialysis patients under continuous therapy with recombinant human erythropoietin].
In earlier studies we have shown that partial correction of anemia by recombinant human erythropoietin (r-HuEPO) already after 12 weeks results in a significant increase of exercise capacity in patients on chronic hemodialysis. As causative effect increased oxygen availability with improved oxygen delivery to the tissues was assumed. To elucidate the long-term effects of a partial correction of anemia with r-HuEPO on exercise capacity, oxygen uptake at maximum exercise and at the anaerobic threshold was measured by repetitive spiroergometry. Measurements were done before, 3 months and 6 months after initiation of r-HuEPO therapy. The results are summarized below: (table; see text) Our results show that a long-term improvement of peripheral oxygen availability leads to a further increase of anaerobic threshold in patients on chronic hemodialysis even without a further increase of hemoglobin levels and without exercise training. It appears that elimination of the chronic hypoxic condition results in a restoration of previously diminished mitochondrial enzymes in muscle, particularly for aerobic glycolysis. Besides acute improvement of aerobic and anaerobic exercise capacity, the long-term administration of r-HuEPO with its increased anaerobic threshold enhances the patients' everyday life working capacity.
Mayer
G
G
Medizinische Universitätsklinik, Wien.
Thum
J
J
Cada
E M
EM
Stummvoll
H K
HK
Graf
H
H
D004921:Erythropoietin / Q000627:therapeutic use*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D010100:Oxygen / Q000097:blood; D005082:Physical Exertion; D006435:Renal Dialysis; D013997:Time Factors
D006454:Hemoglobins; D004921:Erythropoietin; D010100:Oxygen
Verhalten der aeroben und anaeroben Leistungsfähigkeit chronischer Hämodialysepatienten unter einer Dauertherapie mit rekombinantem humanem Erythropoietin.