Inhibition of phosphoglucomutase by fructose 2,6-bisphosphate.
Fructose 2,6-bisphosphate inhibits phosphoglucomutase. The inhibition is mixed with respect to glucose 1,6-bisphosphate and non-competitive with respect to glucose 1-phosphate. In contrast with fructose 1,6-bisphosphate and glycerate 1,3-bisphosphate, which also possess inhibitory effect, fructose 2,6-bisphosphate does not phosphorylate phosphoglucomutase. Fructose 2,6-bisphosphate preparations contain contaminants which can explain artefactual results previously reported.
Bartrons
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R
Carreras
M
M
Climent
F
F
Carreras
J
J
D000818:Animals; D004163:Diphosphoglyceric Acids / Q000494:pharmacology; D005635:Fructosediphosphates / Q000494:pharmacology*; D005958:Glucosephosphates / Q000494:pharmacology; D006598:Hexosediphosphates / Q000494:pharmacology*; D007700:Kinetics; D009132:Muscles / Q000201:enzymology; D010733:Phosphoglucomutase / Q000037:antagonists & inhibitors*; D011817:Rabbits; D013329:Structure-Activity Relationship
D004163:Diphosphoglyceric Acids; D005635:Fructosediphosphates; D005958:Glucosephosphates; D006598:Hexosediphosphates; D010733:Phosphoglucomutase