Gastrin, somatostatin, and alimentary tract growth responses to small intestinal resection in the rat.
We studied the early time-course of gastrin, somatostatin, and gut growth responses to 70% resection of mid-small intestine. Serum and antral gastrin increased by the 2nd day following resection and remained elevated for the 10-day period of study. Antral somatostatin remained unchanged, suggesting that the increase in gastrin was a selective antral response. Duodenum and ileum showed marked growth stimulation, which was progressive with time, and earlier and greater in duodenum. In contrast, gastric growth was unaffected. Thus, early responses to resection are characterized by specificity of gastrin, somatostatin, and growth effects.
Schedl
H P
HP
Medical Service, Veterans Administration Medical Center, Iowa City, Iowa.
Wilson
H D
HD
Solomon
T E
TE
D000818:Animals; D001835:Body Weight; D005755:Gastrins / Q000378:metabolism*; D007421:Intestine, Small / Q000254:growth & development / Q000378:metabolism / Q000601:surgery*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000378:metabolism*
D005755:Gastrins; D013004:Somatostatin