Hepatectomy prolongs survival of mice with induced liver metastases.
Resection of hepatic metastases from colorectal cancer has been shown to prolong survival in some patients. Whether this results from a reduction of tumor burden or is an indirect effect mediated by hepatectomy is questionable. Male C57BL/6Ros 8-week-old mice underwent ileocolic vein injection of a suspension of 0.3 mL of 2 x 10(5) viable liver-derived murine (MCA-38) colonic adenocarcinoma cells. This model produces hepatic metastases in all lobes of the liver. At 7, 14, or 21 days after tumor injection, mice were randomized to receive either 42% resection of the liver or laparotomy alone. Survival in the animals with hepatectomy was significantly prolonged when the hepatectomy was performed 14 or 21 days after tumor injection.
Castillo
M H
MH
Department of Surgery, State University of New York, Buffalo.
Doerr
R J
RJ
Paolini
N
N
Cohen
S
S
Goldrosen
M
M
D000818:Animals; D002460:Cell Line; D003110:Colonic Neoplasms; D006498:Hepatectomy; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL