title: The fate of bone marrow micrometastases in patients with primary breast cancer.
abstract: Using an immunocytochemical technique, micrometastases have been found in the bone marrow of approximately 26% of patients with primary breast cancer at the time of initial surgery. To determine the fate of these cells, both in patients receiving and not receiving adjuvant therapy, multiple bone marrow aspirates were repeated in 82 patients at a median time of 18 months after surgery but prior to overt relapse. In both treated and untreated patients micrometastases were only found in one of 45 (2%) and one of 37 (3%) patients, respectively. However, when multiple marrow aspirates were taken from patients with local recurrence the incidence of micrometastases was 19% (three of 16), and this increased to 30% (three of ten) in patients with disease at distant sites other than bone, and 100% (ten of ten) in patients with radiologically proven bony disease. Three of 11 (27%) patients in whom the primary tumor remained in situ while receiving adjuvant therapy before definitive surgery had micrometastases at the time of diagnosis and at follow-up 3 months later. These results suggest that many of the micrometastases from breast cancer patients are the result of "shedding" of cells from the primary carcinoma and that a proportion are not viable. The technique is currently insufficiently sensitive to accurately monitor adjuvant therapy in breast cancer patients.
authors.affiliation: Ludwig Institute for Cancer Research, St George's Hospital Medical School, London, England.
authors.forename: J L
authors.initials: JL
authors.lastname: Mansi
authors.forename: U
authors.initials: U
authors.lastname: Berger
authors.forename: T
authors.initials: T
authors.lastname: McDonnell
authors.forename: A
authors.initials: A
authors.lastname: Pople
authors.forename: Z
authors.initials: Z
authors.lastname: Rayter
authors.forename: J C
authors.initials: JC
authors.lastname: Gazet
authors.forename: R C
authors.initials: RC
authors.lastname: Coombes
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology*; D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents