title: Plasma binding of 1-butanol, phenol, nitrobenzene and pentachlorophenol in the rainbow trout and rat: a comparative study.
abstract: 1. The in vitro binding of 1-butanol, phenol, nitrobenzene, and pentachlorophenol in trout plasma and rat plasma was determined. 2. Binding to rainbow trout plasma proteins agreed within 9% of that observed in rat plasma. 3. Percentage bound to rainbow trout (2-99%) or rat (10-99%) plasma proteins increased as the log octanol/water partition coefficient of the chemicals increased within the Log P 1-3 range, and was suggestive of hydrophobic interactions in binding.
authors.affiliation: U.S. Environmental Protection Agency, Environmental Research Laboratory-Duluth, MN 55804.
authors.forename: P K
authors.initials: PK
authors.lastname: Schmieder
authors.forename: T R
authors.initials: TR
authors.lastname: Henry
mesh_terms: D020001:1-Butanol; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D000440:Butanols / Q000097:blood*; D002733:Chlorophenols / Q000097:blood*; D009578:Nitrobenzenes / Q000097:blood*; D010416:Pentachlorophenol / Q000097:blood*; D019800:Phenol; D010636:Phenols / Q000097:blood*; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains; D012487:Salmonidae / Q000097:blood*; D014337:Trout / Q000097:blood*
chemical_list: D001798:Blood Proteins; D000440:Butanols; D002733:Chlorophenols; D009578:Nitrobenzenes; D010636:Phenols; D019800:Phenol; D020001:1-Butanol; D010416:Pentachlorophenol; C036077:nitrobenzene