Generalized melanosis in occult primary melanoma.
Once encountered, generalized melanosis as a consequence of disseminated melanoma is not easily forgotten. Cases in the literature usually have resulted from primary cutaneous melanoma. A case of generalized melanosis caused by an occult primary melanoma is reported in a patient who originally complained of increased pigmentation. Findings of light microscopic studies of involved skin, pathogenesis of generalized melanosis, and possible sites of origin of the primary neoplasm are discussed.
Sexton
M
M
Department of Pathology, Pennsylvania State University, Milton S. Hershey Medical Center, Hershey 17033.
Snyder
C R
CR
D000328:Adult; D005148:Facial Dermatoses / Q000209:etiology / Q000473:pathology; D005260:Female; D006229:Hand Dermatoses / Q000209:etiology / Q000473:pathology; D006801:Humans; D008545:Melanoma / Q000556:secondary*; D008548:Melanosis / Q000209:etiology* / Q000473:pathology; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis*; D010051:Ovarian Neoplasms / Q000556:secondary*