title: Sex-related reduced weight gains in growing swine fed diets containing deoxynivalenol.
abstract: A 5-wk feeding trial was conducted with 30 castrated male and 28 female, 5-wk-old crossbred piglets. Three different deoxynivalenol (DON) and zearalenone (Z)-contaminated diets were fed: .7, 3.1 and 5.8 ppm DON and 0, .05, and .1 ppm Z, respectively. The animals were fed their respective diets for 4 wk followed by the .7:0-ppm diet during wk 5. Feed intake and weight gain varied in a manner reciprocal to the levels of DON-Z in the diets during the first 4 wk (P less than .05). The castrated males had an overall lower weight gain compared with the females receiving the same diet (P less than .05). Gross postmortem changes were not different in either sex and tended to be most prominent in the pigs fed the lower DON:Z-contaminated diets after the first week, although they were seen in pigs fed the higher DON:Z diets after 4 wk of feeding. Lesions included mild to moderated reddening of the fundic mucosa of the stomach, reddening of the mucosa of the small intestine, and mild to moderate enlargement and edema of the mesenteric lymph nodes. Similarly, the severity of histologic changes tended to vary inversely with the concentrations of DON:Z in the diets after the first week but varied with the concentrations of DON:Z after 4 wk. They consisted of vascular congestion with mild to moderate multifocal erosions and degeneration of the mucosa in the stomach and small intestine. Mild to moderate lymphoid degeneration and depletion were also observed in the Peyer's patches of the intestines, bronchial and mesenteric lymph nodes, spleen, tonsil and thymus.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.forename: L M
authors.initials: LM
authors.lastname: Cote
authors.forename: V R
authors.initials: VR
authors.lastname: Beasley
authors.forename: P M
authors.initials: PM
authors.lastname: Bratich
authors.forename: S P
authors.initials: SP
authors.lastname: Swanson
authors.forename: H L
authors.initials: HL
authors.lastname: Shivaprasad
authors.forename: W B
authors.initials: WB
authors.lastname: Buck
mesh_terms: D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000662:veterinary; D008297:Male; D010052:Ovariectomy; D012118:Resorcinols / Q000633:toxicity*; D012717:Sesquiterpenes / Q000633:toxicity*; D013552:Swine / Q000254:growth & development*; D013553:Swine Diseases / Q000139:chemically induced; D014018:Tissue Distribution; D014255:Trichothecenes / Q000378:metabolism / Q000633:toxicity*; D015025:Zearalenone / Q000378:metabolism / Q000633:toxicity*
chemical_list: D012118:Resorcinols; D012717:Sesquiterpenes; D014255:Trichothecenes; D015025:Zearalenone; C007262:deoxynivalenol