[Amino acid sequence of neurotoxins IV and V from the sea anemone Radianthus macrodactylus].
Amino acid sequences of neurotoxins RTX-IV and RTX-V isolated from the sea anemone Radianthus macrodactylus were determined by the automated Edman degradation; their polypeptide chains consist of 48 and 47 amino acid residues, respectively. For identification of tryptophan-30 in toxin RTX-IV, its trypsin and chymotrypsin digests were investigated. Amino acid sequences of the above toxins show that they belong to a new structural class and that C-terminal positive charge and tyrosine-25 are important for toxic activity of sea anemone polypeptides.
Zykova
T A
TA
Kozlovskaia
E P
EP
Eliakov
G B
GB
D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003063:Cnidaria; D003064:Cnidarian Venoms / Q000032:analysis*; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000032:analysis*; D012615:Sea Anemones
D003064:Cnidarian Venoms; D009498:Neurotoxins; C055387:toxin IV (Anemonia sulcata); C035569:toxin V (Anemonia sulcata)
Aminokislotnaia posledovatel'nost' neĭrotoksinov IV i V iz aktinii Radianthus macrodactylus.