title: Direct observation of native DNA structures with the scanning tunneling microscope.
abstract: Uncoated double-stranded DNA dissolved in a salt solution was deposited on graphite and imaged in air with the scanning tunneling microscope (STM). The resolution was such that the major and minor grooves could be distinguished. The pitch of the helix varied between 27 and 63 angstroms in the images obtained. Thus the STM can be useful for structural studies of a variety of uncoated and isolated biomolecules.
authors.affiliation: Lawrence Livermore National Laboratory, Department of Chemistry, Livermore, CA 94550.
authors.forename: T P
authors.initials: TP
authors.lastname: Beebe
authors.forename: T E
authors.initials: TE
authors.lastname: Wilson
authors.forename: D F
authors.initials: DF
authors.lastname: Ogletree
authors.forename: J E
authors.initials: JE
authors.lastname: Katz
authors.forename: R
authors.initials: R
authors.lastname: Balhorn
authors.forename: M B
authors.initials: MB
authors.lastname: Salmeron
authors.forename: W J
authors.initials: WJ
authors.lastname: Siekhaus
mesh_terms: D000818:Animals; D002417:Cattle; D004247:DNA / Q000648:ultrastructure*; D008855:Microscopy, Electron, Scanning / Q000295:instrumentation / Q000379:methods*; D009690:Nucleic Acid Conformation
chemical_list: D004247:DNA