Naloxone therapy of human septic shock.
A 0.01 and 0.1-mg/kg dose of iv naloxone was administered to seven patients in septic shock, in order to evaluate naloxone's hemodynamic effect and possible relation to changes in plasma beta-endorphin and catecholamine levels. Naloxone failed to modify cardiac index, blood pressure, heart rate, and systemic vascular resistance. Plasma beta-endorphin, norepinephrine, and epinephrine were elevated but did not change after naloxone administration. These results suggest that beta-endorphin release is a consequence but not a cause of shock, and that the beneficial hemodynamic effects of naloxone in animal studies could be related to species differences or nociceptive stimulations.
Bonnet
F
F
Bilaine
J
J
Lhoste
F
F
Mankikian
B
B
Kerdelhue
B
B
Rapin
M
M
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000150:complications; D004723:Endorphins / Q000097:blood; D004837:Epinephrine / Q000097:blood; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000627:therapeutic use*; D009638:Norepinephrine / Q000097:blood; D012772:Shock, Septic / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D001615:beta-Endorphin
D004723:Endorphins; D009270:Naloxone; D001615:beta-Endorphin; D009638:Norepinephrine; D004837:Epinephrine