title: Cause of persistent hypouricemia in outpatients.
abstract: We measured serum urate in 3,258 Japanese outpatients. Five of them had persistent hypouricemia. Three also had microhematuria. Four of the five patients were proven to have renal uricosuria with hypouricemia, but otherwise normal tubular function. When tested with both pyrazinamide and benzbromarone, 1 patient had a presecretory reabsorption defect, 2 had postabsorption defects, and 1 an enhanced renal tubular secretion of urate. These results suggest that persistent hypouricemia in outpatients is of very low incidence, is usually caused by an isolated metabolic error of urate transport, and is not related to drug ingestion or systemic disease.
authors.affiliation: 1st Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Hisatome
authors.forename: K
authors.initials: K
authors.lastname: Ogino
authors.forename: H
authors.initials: H
authors.lastname: Kotake
authors.forename: R
authors.initials: R
authors.lastname: Ishiko
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: J
authors.initials: J
authors.lastname: Hasegawa
authors.forename: H
authors.initials: H
authors.lastname: Mashiba
authors.forename: S
authors.initials: S
authors.lastname: Nakamoto
mesh_terms: D001553:Benzbromarone; D005260:Female; D006417:Hematuria / Q000150:complications; D006801:Humans; D008297:Male; D010045:Outpatients; D010361:Patients; D011718:Pyrazinamide; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D011718:Pyrazinamide; D001553:Benzbromarone