title: Evidence for the monomeric nature of thymosins.
abstract: According to gel-filtration experiments, alpha- and beta-thymosins appear to form oligomers, which are 4-5-fold larger than the corresponding polypeptides. However, on analysis by sedimentation equilibrium ultracentrifugation, prothymosin alpha and thymosin beta 4 showed relative molecular masses of 12,800 and 4600, which are close to the values calculated from their amino acid sequences, confirming their existence in solution as discrete monomeric entities.
authors.affiliation: Zoological Laboratory, Faculty of Sciences, University of Athens, Greece.
authors.forename: A A
authors.initials: AA
authors.lastname: Haritos
authors.forename: P P
authors.initials: PP
authors.lastname: Yialouris
authors.forename: E P
authors.initials: EP
authors.lastname: Heimer
authors.forename: A M
authors.initials: AM
authors.lastname: Felix
authors.forename: E
authors.initials: E
authors.lastname: Hannappel
authors.forename: M A
authors.initials: MA
authors.lastname: Rosemeyer
mesh_terms: D000818:Animals; D002417:Cattle; D002850:Chromatography, Gel; D046911:Macromolecular Substances; D008970:Molecular Weight; D011498:Protein Precursors; D000077596:Thymalfasin; D013947:Thymosin / Q000031:analogs & derivatives / Q000302:isolation & purification; D013950:Thymus Gland / Q000032:analysis; D000099201:Thymosin beta(4)
chemical_list: D046911:Macromolecular Substances; D011498:Protein Precursors; D000077596:Thymalfasin; D013947:Thymosin; D000099201:Thymosin beta(4); C040782:prothymosin alpha; C044498:parathymosin alpha