title: Statistical analysis of the micronucleus test--a modelling approach.
abstract: This paper suggests an approach according to the principle that 'An experimental design is related to a statistical model describing that particular design'. A simple linear model approach is presented as an alternative to earlier proposed multiple single tests which is suitable for situations in which there are just a few dose levels and expression times. Furthermore, the aim is to move from significance testing towards a modelling and estimation procedure in order to find a structure and try to evaluate what is being determined in the experiment.
authors.affiliation: Department of Medical Information Processing, Karolinska Institute, Stockholm, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Brodin
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000187:drug effects; D051379:Mice; D015162:Micronucleus Tests; D008957:Models, Genetic; D015233:Models, Statistical; D009942:Organometallic Compounds / Q000494:pharmacology; D011336:Probability; D012107:Research Design
chemical_list: D009942:Organometallic Compounds; C008261:lead acetate