title: Perinatal anti-androgen treatment and genotype affect the mesotelencephalic dopamine system and behavior in mice.
abstract: Sex and strain differences in tyrosine hydroxylase activity (TH) of brain dopamine systems have been reported for mice. To investigate if there might be a causal relationship between perinatal androgen secretion and regional mesotelencephalic TH activity, BALB/cJ and C57BL/6ByJ male mice were treated perinatally with cyproterone, a steroidal anti-androgen (or vehicle), and orchiectomized at 1 month of age. Two-way analysis of variance indicated significant treatment and strain effects in the mesencephalon and tuber olfactorium: perinatal cyproterone treatment lowered TH activity, and BALB/cJ had higher regional TH activities than those of C57BL/6ByJ. The most prominent behavioral effects of cyproterone treatment were found in the expression of scratching, which was considerably increased in both strains. Possible implications of these results are discussed.
authors.affiliation: Nathan S. Kline Institute, Orangeburg, New York 10962.
authors.forename: C
authors.initials: C
authors.lastname: Vadász
authors.forename: G
authors.initials: G
authors.lastname: Kobor
authors.forename: P
authors.initials: P
authors.lastname: Kabai
authors.forename: I
authors.initials: I
authors.lastname: Sziráki
authors.forename: I
authors.initials: I
authors.lastname: Vadász
authors.forename: A
authors.initials: A
authors.lastname: Lajtha
mesh_terms: D000818:Animals; D001143:Arousal / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects; D003534:Cyproterone / Q000494:pharmacology*; D005260:Female; D008297:Male; D008636:Mesencephalon / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D009830:Olfactory Bulb / Q000187:drug effects; D011247:Pregnancy; D011954:Receptors, Dopamine / Q000187:drug effects*; D013045:Species Specificity; D013378:Substantia Nigra / Q000187:drug effects; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D011954:Receptors, Dopamine; D003534:Cyproterone; D014446:Tyrosine 3-Monooxygenase