Effects of an extract of feverfew on endothelial cell integrity and on cAMP in rabbit perfused aorta.
Extracts of feverfew inhibit platelet aggregation and secretion of granular contents from platelets and other cells. They also modify the interaction of platelets with collagen substrates: feverfew extracts inhibit both platelet spreading and formation of thrombus-like platelet aggregates on the collagen surface. We have now investigated the effect of an extract of feverfew on the vessel wall using rabbit aortas that were perfused with a physiological salt solution in-situ. Addition of feverfew extract to the perfusion medium protected the endothelial cell monolayer from perfusion-induced injury and led to a reversible increase in the cAMP content of aorta segments. The results indicate that feverfew may have a vasoprotective effect in addition to its effects on platelets.
Voyno-Yasenetskaya
T A
TA
Institute of Experimental Cardiology, USSR Cardiology Research Centre, Moscow.
Loesche
W
W
Groenewegen
W A
WA
Heptinstall
S
S
Repin
V S
VS
Till
U
U
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology* / Q000187:drug effects; D066298:In Vitro Techniques; D007700:Kinetics; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011817:Rabbits; D012016:Reference Values
D010936:Plant Extracts; D000242:Cyclic AMP