Diazepam--morphine hypnotic synergism in rats.
The effect of diazepam-morphine combination on the righting reflex was studied in rats. Doses of the drugs given alone and in combination that block righting reflex (RR ED50) were determined with a probit procedure. Brain concentrations following equieffective doses of the drugs administered separately and in combination were determined by radioimmunoassay. Equieffective intravenous doses and corresponding brain concentrations for the agents were compared with fractional (algebraic) and isobolographic analyses. Interaction between diazepam and morphine was found to be synergistic. It is not likely to be pharmacokinetic in nature.
Kissin
I
I
Department of Anesthesiology, School of Medicine, University of Alabama, Birmingham.
Brown
P T
PT
Bradley
E L
EL
Robinson
C A
CA
Cassady
J L
JL
D000818:Animals; D003975:Diazepam / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D011187:Posture / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000187:drug effects
D009020:Morphine; D003975:Diazepam