L-671,329, a new antifungal agent. II. Structure determination.
Based on spectroscopic data L-671,329, isolated from a filamentous fungus ATCC 20868, has been assigned the structure 1. The compound is a lipopeptide antifungal agent and a structural analog of echinocandin B.
Wichmann
C F
CF
Department of Natural Products Research, Merck Sharp & Dohme Research Laboratories, Rahway, N.J. 07065-0900.
Liesch
J M
JM
Schwartz
R E
RE
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010455:Peptides; D010456:Peptides, Cyclic; D013056:Spectrophotometry, Ultraviolet
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins; D010455:Peptides; D010456:Peptides, Cyclic; C058995:pneumocandin A(0); C007572:echinocandin B