title: Cystic fibrosis: typing 89 German families with linked DNA probes.
abstract: Three hundred and ninety-two subjects from 89 German families were typed for restriction fragment length polymorphisms (RFLPs) detected by the probes pmetH, pmetD, pJ3.11, KM19, and XV2c known to be tightly linked to the cystic fibrosis (CF) gene. The analysis of the predictive value of this typing in individual CF families indicates that the combined use of these probes provides a powerful diagnostic system for both carrier detection and prenatal diagnosis. In 45 families the complete haplotype including all RFLPs was available. Of them 41 (91.1%) were fully informative and 4 were partly informative.
authors.affiliation: Institut für Klinische Biochemie, Universität, Bonn, Federal Republic of Germany.
authors.forename: J
authors.initials: J
authors.lastname: Weber
authors.forename: C
authors.initials: C
authors.lastname: Aulehla-Scholz
authors.forename: R
authors.initials: R
authors.lastname: Kaiser
authors.forename: A
authors.initials: A
authors.lastname: Eigel
authors.forename: M
authors.initials: M
authors.lastname: Neugebauer
authors.forename: J
authors.initials: J
authors.lastname: Horst
authors.forename: K
authors.initials: K
authors.lastname: Olek
mesh_terms: D000483:Alleles; D003550:Cystic Fibrosis / Q000235:genetics*; D015342:DNA Probes; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011237:Predictive Value of Tests
chemical_list: D015342:DNA Probes; D005819:Genetic Markers