Radiation therapy-associated invasive bladder tumors.
Radiotherapy-associated bladder carcinoma was found in 3.7 percent of 244 cases of advanced urothelial carcinoma. Average age at diagnosis of the bladder tumor was 63.1 years, with a mean of 20.5 years between radiation treatment and diagnosis. All 9 patients presented with gross hematuria. Eight patients had transitional cell carcinoma, 7/8 (87.5%) also had vascular or lymphatic invasion, and 1 was adenocarcinoma. Mean survival was 15.4 months (range 1-40 mos.), with a 55.5 percent one-year disease-free survival after diagnosis. Four patients died of bladder tumor, 4 were alive with no evidence of disease, and 1 was alive with metastasis.
Sella
A
A
Division of Medicine, University of Texas M. D. Anderson Cancer Center, Houston.
Dexeus
F H
FH
Chong
C
C
Ro
J Y
JY
Logothetis
C J
CJ
D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000628:therapy; D010386:Pelvic Neoplasms / Q000532:radiotherapy; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000209:etiology* / Q000628:therapy