Teratogenesis and reproductive safety evaluation of the retinoid etretin (Ro 10-1670).
Reproduction and teratology studies were performed with etretin, the free acid analog of the retinoid etretinate. The lowest teratogenic dose of etretin in mice, rats and rabbits was 3, 15 and 0.6 mg/kg, respectively. In all three species, the lowest dose which was embryolethal, fetolethal or reduced the survivability of the pups during lactation was 2-3 times higher than the above doses. In rats, the lowest effective dose of etretin was 3 mg/kg in both the study for fertility and general reproductive performance and the peri- and postnatal study. The main adverse effect in these two experiments was a reduced survival of the F1-generation.
Kistler
A
A
Hummler
H
H
D000014:Abnormalities, Drug-Induced / Q000209:etiology* / Q000473:pathology; D017255:Acitretin; D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D013723:Teratogens; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000633:toxicity
D013723:Teratogens; D014212:Tretinoin; D017255:Acitretin