title: Relationship between virulence of Chlamydia psittaci strains and establishment of persistent infection of McCoy cells.
abstract: The pathogenicity of chlamydial strains for their natural hosts and their ability to induce persistent infections in McCoy cells were compared. Both virulent and avirulent strains persistently infected McCoy cells, but the appearance of the cell culture varied between strains. Avirulent strains induced completely inapparent persistent infection (infection Type 1), while with invasive strains the culture alternated between periods of cell multiplication and periods of extensive cytopathic change (infection Type 2). The virulence of virulent strains was not attenuated, even after 6 months of culture, but after 2 or 3 months some avirulent strains produced infection Type 2 and became invasive for mice and abortive for ewes. This variation of virulence was accompanied by a modification of protein patterns.
authors.affiliation: Station de Pathologie de la Reproduction, INRA, Monnaie, France.
authors.forename: A
authors.initials: A
authors.lastname: Rodolakis
authors.forename: F
authors.initials: F
authors.lastname: Bernard
authors.forename: A
authors.initials: A
authors.lastname: Souriau
authors.forename: K
authors.initials: K
authors.lastname: Layachi
authors.forename: D
authors.initials: D
authors.lastname: Buzoni-Gatel
mesh_terms: D000034:Abortion, Veterinary / Q000382:microbiology*; D000818:Animals; D002460:Cell Line; D002691:Chlamydophila psittaci / Q000472:pathogenicity*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D051379:Mice; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000662:veterinary*; D009956:Psittacosis / Q000382:microbiology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000382:microbiology*; D014764:Viral Proteins / Q000032:analysis; D014774:Virulence
chemical_list: D014764:Viral Proteins