title: Comparison between in vivo and in vitro cutaneous penetration of fenvalerate in tobacco budworm (Lepidoptera: Noctuidae).
abstract: In vivo and in vitro penetration of fenvalerate were compared in the 3-d-old fifth-instar tobacco budworm, Heliothis virescens (F). In the in vitro studies, a piece of cuticle was excised and mounted on a diffusion cell, and the amount of radioactivity present in the cuticle and medium was determined at various time intervals. At 24 h, approximately 7.4% of the dose was located in the cuticle, whereas only 1.6% actually penetrated. In the in vivo studies, approximately 7.4% of the radioactivity was recovered from the body after cuticular wash.
authors.forename: R E
authors.initials: RE
authors.lastname: Grissom
authors.forename: T
authors.initials: T
authors.lastname: Konno
authors.forename: N
authors.initials: N
authors.lastname: Motoyama
authors.forename: W C
authors.initials: WC
authors.lastname: Dauterman
mesh_terms: D000818:Animals; D006801:Humans; D007231:Infant, Newborn; D007915:Lepidoptera / Q000378:metabolism*; D009570:Nitriles; D011722:Pyrethrins / Q000493:pharmacokinetics*
chemical_list: D009570:Nitriles; D011722:Pyrethrins; C017690:fenvalerate