Uterine tumors in ataxia-telangiectasia.
Roughly one-third of patients with ataxia-telangiectasia (AT) develop malignant tumors, usually of lymphoid origin. AT patients also exhibit progeric changes. We describe three patients, between the ages of 27 and 32 years, with uterine tumors: one with a frank leiomyosarcoma and chronic T-cell leukemia, one with a multilobulated leiomyoma of uncertain malignant potential, and one with an unremarkable leiomyoma. Thus, the spectrum of tumors in AT patients beyond adolescence includes nonlymphoid malignancies and precocious, benign leiomyomas.
Gatti
R A
RA
Department of Pathology, UCLA School of Medicine 90024.
Nieberg
R
R
Boder
E
E
D000328:Adult; D001260:Ataxia Telangiectasia / Q000150:complications*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000209:etiology / Q000473:pathology; D007890:Leiomyosarcoma / Q000209:etiology / Q000473:pathology; D015458:Leukemia, T-Cell / Q000150:complications / Q000209:etiology; D014594:Uterine Neoplasms / Q000209:etiology* / Q000473:pathology