Kinetics of the MLR response following single donor-specific allogeneic blood transfusions.
Prior blood transfusion (BT) confers a significant improvement in transplant survival in recipients (1). However, increased survival across major histocompatibility barriers generally requires the administration of immunosuppressive agents (2-5). The mechanisms by which BT prolongs graft survival have not been fully elucidated. Experimental evidence suggests that suppressor cells (6,7), soluble suppressor factors (8), and blocking antibodies (9) may play a role.
Fox
B A
BA
Westrick
P W
PW
Nathanson
S D
SD
D000818:Animals; D001803:Blood Transfusion; D005260:Female; D007156:Immunologic Memory; D007700:Kinetics; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D013154:Spleen / Q000276:immunology