Prevention of stress ulcer by intragastric glucose. An experimental study.
Stress ulcer is a condition seen after major trauma and surgery, sepsis, shock and extensive burns so its prevention is very important. Cimetidine and antacids are the drugs most often administered for prevention. Sometimes these drugs are insufficient and complications and side-effects appear. In order to prevent stress ulcers, experimental administration of intragastric glucose has been tested. A 30% dextrose solution given intragastrically decreased both luminal acidity and mean ulcer index. Similar results were obtained with intragastric 0.9% NaCl. The results showed that a luminal factor, not identified in this experiment, is present.
Oguz
M
M
Department of General Surgery, Cumhuriyet University, Sivas, Turkey.
Yildirir
G C
GC
D000284:Administration, Oral; D000818:Animals; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use; D005947:Glucose / Q000008:administration & dosage* / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D051381:Rats; D013276:Stomach Ulcer / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*
D002927:Cimetidine; D005947:Glucose