[Treatment of meningeal carcinomatosis--neocarzinostatin perfusion therapy in the CSF pathway].
The authors presented the results of perfusion chemotherapy in the CSF pathway with neocarzinostatin (NCS) for the treatment of meningeal carcinomatosis. In three cases of stomach cancer and one case of malignant lymphoma, cranial polyneuropathy, progressive hydrocephalus and positive cytology of the CSF were found during treatment of malignant tumors. NCS therapy was performed by means of perfusion from the spinal subarachnoid space to the ventricle utilizing Ommaya's reservoir, or simply by repeated lumbar punctures. In all of four cases the number of malignant cells in the CSF was significantly diminished, and temporary neurological improvement was observed until the patient's death due to advanced primary lesions. These results indicated that in cases of meningeal carcinomatosis, NCS perfusion therapy using the CSF pathway was a much more favorable method than treatment with other chemotherapeutic agents with less noticeable side effects.
Uemura
S
S
Matsukado
Y
Y
Fujioka
S
S
Kuratsu
J
J
Sonoda
H
H
Yano
T
T
Ohtsuka
T
T
Yoshioka
S
S
D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D002552:Cerebral Ventricles; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000134:cerebrospinal fluid / Q000150:complications*; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D008875:Middle Aged; D010477:Perfusion; D013274:Stomach Neoplasms / Q000134:cerebrospinal fluid / Q000150:complications*; D013346:Subarachnoid Space; D009353:Zinostatin / Q000008:administration & dosage / Q000627:therapeutic use*
D000903:Antibiotics, Antineoplastic; D009353:Zinostatin