Prediction of the effect of ofloxacine on intestinal absorption: effect of the body weight and substrate concentration.
1. The effect of body weight and initial concentration on the rat small intestinal absorption of DL-8280 (ofloxacine) is studied using a recirculating perfusion technique and an improved HPLC method. 2. A prediction equation is developed under statistical and physiological considerations which correlates both factors with the intestinal absorption rate parameter Kapp.
Prieto
J G
JG
Cátedra de Fisiologia Animal, Universidad de León, Spain.
Barrio
J P
JP
Gómez
G
G
Melcón
B
B
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects*; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D015242:Ofloxacin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D000890:Anti-Infective Agents; D015242:Ofloxacin