title: Prostaglandin synthetase inhibitors in feverfew.
abstract: The IC50 values for the in-vitro inhibition of the prostaglandin synthetase (bovine seminal vesicle mitochondrial fraction) mediated PGE2 production from arachidonic acid by parthenolide, michefuscalide and chrysanthenyl acetate were 11.0 +/- 0.44, 12.1 +/- 0.51 and 14.2 +/- 0.58 microM (mean +/- 95% confidence limits), respectively.
authors.affiliation: Welsh School of Pharmacy, UWIST, Cardiff, UK.
authors.forename: W J
authors.initials: WJ
authors.lastname: Pugh
authors.forename: K
authors.initials: K
authors.lastname: Sambo
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000302:isolation & purification / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors; D039821:Monoterpenes; D010946:Plants, Medicinal / Q000032:analysis*; D011453:Prostaglandins / Q000096:biosynthesis; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology
chemical_list: D001643:Bridged Bicyclo Compounds; D016861:Cyclooxygenase Inhibitors; D039821:Monoterpenes; D011453:Prostaglandins; D012717:Sesquiterpenes; C002669:parthenolide; C059209:chrysanthenyl acetate; C059287:michefucscalide