Monaural and binaural audiogenic seizures in mice.
The progression of sound-induced seizures was examined in unilaterally or bilaterally sensitized SJL/J mice tested either monaurally or binaurally. An unexpected right-side advantage for becoming susceptible to audiogenic seizure was observed. In addition, two distinct patterns of seizure progression were noted, a uniphasic sequence in which a single burst of running preceded the convulsion and a biphasic pattern with two such bursts. The biphasic progression is viewed to be the result of unilaterally initiated seizures and characteristically reached only a clonic level of severity. Uniphasic seizures are concluded to be the result of bilaterally initiated seizures and, when they occurred after more than 30 s of auditory stimulation, frequently reached a tonic level of intensity. The present results support the view that audiogenic seizures are characterized by precisely timed, sequential processes dependent upon the specific priming and test procedures employed.
Reid
H M
HM
Department of Psychology, State University College, Buffalo, New York 14222.
Collins
R L
RL
D000161:Acoustic Stimulation / Q000379:methods*; D000818:Animals; D004292:Dominance, Cerebral; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011930:Reaction Time; D012640:Seizures / Q000209:etiology*