title: Polyclonal B cell activators inhibit contact sensitivity to oxazolone in mice by potentiating the production of anti-hapten antibodies that induce T suppressor lymphocytes acting through the release of soluble factors.
abstract: Polyclonal B cell activators (PBAs) such as purified protein derivative, lipopolysaccharide, Staphylococcus aureus strain Cowan I (StaCwI), and Pseudomonas aeruginosa inhibit contact sensitivity to oxazolone in mice when given 24 h before sensitization. This suppression, transferable from immunodepressed animals to oxazolone-sensitized recipients with immune serum, has been shown to be due to the early appearance of anti-hapten antibodies. These antibodies elicit T suppressor cells which release soluble factor(s) capable of inhibiting the passive transfer of contact sensitivity.
authors.forename: M
authors.initials: M
authors.lastname: Campa
authors.forename: G
authors.initials: G
authors.lastname: De Libero
authors.forename: G
authors.initials: G
authors.lastname: Benedettini
authors.forename: L
authors.initials: L
authors.lastname: Mori
authors.forename: M R
authors.initials: MR
authors.lastname: Angioni
authors.forename: P
authors.initials: P
authors.lastname: Marelli
authors.forename: G
authors.initials: G
authors.lastname: Falcone
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D003877:Dermatitis, Contact / Q000276:immunology*; D006241:Haptens / Q000276:immunology*; D007107:Immune System / Q000276:immunology; D008222:Lymphokines / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D000906:Antibodies; D006241:Haptens; D008222:Lymphokines