Effects of glucocorticoids and catecholamines on maturing rat heart.
1. The negative force-frequency response of normal rat heart was accentuated when the animals were adrenalectomized. Treatment of adrenalectomized animals with dexamethasone restored the normal force-frequency response. 2. Total adrenalectomy increased the sensitivity of rat heart to calcium. 3. Adrenalectomized-dexamethasone-treated hearts were more responsive to epinephrine and ouabain. 4. Total adrenalectomy caused independent myocardial disturbances in calcium handling elements (glucocorticoid effect) and beta receptors (catecholamine effect).
Penefsky
Z J
ZJ
Department of Physiology and Biophysics, Mount Sinai School of Medicine of the City University of New York 10029.
D000315:Adrenalectomy; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002395:Catecholamines / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology; D004558:Electric Stimulation; D004837:Epinephrine / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000254:growth & development; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010042:Ouabain / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D002395:Catecholamines; D005938:Glucocorticoids; D010042:Ouabain; D003907:Dexamethasone; D002118:Calcium; D004837:Epinephrine