Pharmacokinetics and excretion of iohexol after lumbar myelography in man.
Pharmacokinetics and excretion of iohexol, a new nonionic water-soluble contrast medium, were determined after lumbar myelography. Peak plasma concentrations were obtained 2 to 6 hours after injection and ranged from 29 to 177 microgram/ml. Terminal elimination half-life was 4.0 hours, and over 90% of the dose was recovered in the urine within 24 hours. In one patient with a large lumbar cauda equina tumor, absorption and excretion were delayed; but eventually 99% was recovered indicating a large capacity for reabsorption via the lumbar subarachnoid space. One mild headache of 5 minutes' duration was reported in a 73-year-old woman. No significant changes in vital signs, neurologic examinations, or serum chemistries were observed.
Shaw
D D
DD
Kido
D K
DK
Stroshane
R M
RM
Palace
G P
GP
Sahler
L
L
D000328:Adult; D000368:Aged; D001416:Back Pain / Q000000981:diagnostic imaging; D002420:Cauda Equina / Q000378:metabolism; D003287:Contrast Media / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000378:metabolism; D007463:Iodobenzoates / Q000378:metabolism*; D007472:Iohexol; D007700:Kinetics; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009192:Myelography; D009442:Neurilemmoma / Q000378:metabolism; D010524:Peripheral Nervous System Neoplasms / Q000378:metabolism; D013130:Spinal Stenosis / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids / Q000378:metabolism*
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D007472:Iohexol