Danazol-induced cholestasis.
A 39-yr-old female on high-dose Danazol presented with jaundice and pruritus. Danazol-induced cholestasis was suspected, and the drug was discontinued. A liver biopsy revealed panlobular cholestasis with portal and periportal inflammation. The cholestasis resolved completely in 8 wk. This is a rare case of Danazol-induced cholestasis and should be considered in the differential diagnosis of drug-induced liver injury.
Silva
M O
MO
Center for Liver Diseases, University of Miami School of Medicine, VA Medical Center, Florida.
Reddy
K R
KR
McDonald
T
T
Jeffers
L J
LJ
Schiff
E R
ER
D000328:Adult; D002779:Cholestasis / Q000139:chemically induced* / Q000473:pathology; D003613:Danazol / Q000009:adverse effects*; D004715:Endometriosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D010386:Pelvic Neoplasms / Q000188:drug therapy; D011245:Pregnadienes / Q000009:adverse effects*
D011245:Pregnadienes; D003613:Danazol