[Dynamic changes in the heart beat frequency of rabbits to auditory and nociceptive signals against the background of neuroleptic action].
Aminazine and haloperidol exerted different effects upon spontaneous heart rate and the reactivity of cardiovascular system in curarized rabbits during habituation to nociceptive and sound signals: aminazine (8-10 mg/kg) increased the heart rate by 8-12% and completely suppressed the reactivity, whereas haloperidol (0.5-1.7 mg/kg) decreased the heart rate by 5.0-8.5% and considerably enhanced the reactivity to sound and nociceptive signals, prolonging the habituation duration. The biphasic response of the rabbit heart rate reveals a working mechanism of the baroreflex control over emotionally significant and stressful effects.
Trubachev
V V
VV
Solov'eva
N E
NE
D000161:Acoustic Stimulation; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects; D004558:Electric Stimulation; D004562:Electrocardiography; D005108:Extinction, Psychological / Q000187:drug effects; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D010146:Pain / Q000503:physiopathology*; D011817:Rabbits
D014150:Antipsychotic Agents; D006220:Haloperidol; D002746:Chlorpromazine
Dinamika izmeneniĭ chastoty serdtsebieniĭ krolika na zvukovoĭ i notsitseptivnyĭ signaly na fone deĭstviia neĭroleptika.