Dopamine-mediated behaviour following chronic treatment with B-HT 920.
Following subchronic (5-day) dosing with B-HT 920 (2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo(4,5-d)azepine (1 mg kg-1 day-1 i.p.) in rats there was a significant increase in both apomorphine-induced motor activity and stereotypy. On continued B-HT 920 treatment, however, the enhancement of apomorphine motor activity faded into insignificance but the increase in stereotypy persisted beyond 15 days. The results are discussed in terms of dopamine autoreceptor tolerance, postsynaptic D2 supersensitivity and possible differential effects in different brain loci on the above two receptor sub-classes.
Darmani
N A
NA
Welsh School of Pharmacy, UWIST, Cardiff, UK.
Sewell
R D
RD
Nicholls
P J
PJ
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001381:Azepines / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013239:Stereotyped Behavior / Q000187:drug effects*
D000316:Adrenergic alpha-Agonists; D001381:Azepines; C024763:talipexole; D001058:Apomorphine; D004298:Dopamine