Metabolism and nephrotoxicity of tetralin in male Fischer 344 rats.
Tetralin, a component of fuels, solvents, and varnishes, is metabolized in male Fischer 344 rats to 1-tetralol, 2-tetralol, 2-hydroxyl-1-tetralone, 4-hydroxyl-1-tetralone, 1,2-tetralindiol, and 1,4-tetralindiol. Rats treated with tetralin demonstrated the classic lesions of hydrocarbon-induced nephropathy.
Servé
M P
MP
Department of Chemistry, Wright State University, Dayton, Ohio 45435.
Llewelyn
B M
BM
Yu
K O
KO
McDonald
G M
GM
Olson
C T
CT
Hobson
D W
DW
D000818:Animals; D002849:Chromatography, Gas; D004781:Environmental Exposure; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000652:urine*; D008297:Male; D009281:Naphthalenes / Q000378:metabolism*; D010150:Paint / Q000009:adverse effects; D051381:Rats; D011916:Rats, Inbred F344; D012997:Solvents / Q000009:adverse effects; D013764:Tetrahydronaphthalenes / Q000009:adverse effects / Q000378:metabolism* / Q000633:toxicity
D009281:Naphthalenes; D012997:Solvents; D013764:Tetrahydronaphthalenes