[Occurrence of atypical histamine H2 receptors in the wall of the frog subclavian vein].
Selective H2-histamine agonist dimaprit was shown to produce relaxation of the isolated frog subclavian vein, with it persisting under the effect of selective H2-histamine antagonist cimetidine. Possible nonspecific mechanisms of relaxation produced by histamine are discussed. The data presented do not exclude that there are atypical H2-histamine receptors in subclavian vein of frogs, the activation of which initiates the attenuation of the active tension.
Gol'dfarb
V L
VL
Protas
L L
LL
Sysoev
V V
VV
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D017259:Dimaprit; D066298:In Vitro Techniques; D011896:Rana temporaria; D011968:Receptors, Histamine / Q000032:analysis*; D011970:Receptors, Histamine H2 / Q000032:analysis*; D013350:Subclavian Vein / Q000032:analysis* / Q000187:drug effects; D013890:Thiourea / Q000494:pharmacology
D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D002927:Cimetidine; D013890:Thiourea; D017259:Dimaprit
O sushchestvovanii atipichnykh H2-gistaminovykh retseptorov v stenke podkliuchichnoĭ veny liagushki.