title: Controlled release of dopamine from a polymeric brain implant: in vitro characterization.
abstract: A biocompatible polymeric matrix system for the long-term controlled release of dopamine has been developed. Solid particles of this bioactive agent were encapsulated in ethylene-vinyl acetate copolymer (EVAc). Following immersion in an aqueous buffer solution, the release rate of dopamine from the polymer matrix was found to depend on the initial concentration of dopamine in the polymer. After coating the matrix devices with an additional impermeable layer of EVAc, constant rates of release were obtained by creating a cavity in this impermeable layer. The observed experiments are consistent with a diffusion-limited model of dopamine release; all the in vitro experimental results were therefore correlated by the effective diffusion coefficient of dopamine through the porous polymer network. These results are discussed in terms of potential design modifications to achieve desired release characteristics for a variety of neuroactive substances, including neurotransmitters or their precursors.
authors.affiliation: Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139.
authors.forename: A
authors.initials: A
authors.lastname: Freese
authors.forename: B A
authors.initials: BA
authors.lastname: Sabel
authors.forename: W M
authors.initials: WM
authors.lastname: Saltzman
authors.forename: M J
authors.initials: MJ
authors.lastname: During
authors.forename: R
authors.initials: R
authors.lastname: Langer
mesh_terms: D001921:Brain / Q000378:metabolism; D003692:Delayed-Action Preparations; D004298:Dopamine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004343:Drug Implants; D008433:Mathematics; D009994:Osmolar Concentration; D011108:Polymers; D019736:Prostheses and Implants
chemical_list: D003692:Delayed-Action Preparations; D004343:Drug Implants; D011108:Polymers; D004298:Dopamine