title: [Studies on the biological function of the nucleotide base of vitamin B12].
abstract: Studies on the coenzyme activity of some nucleotide base analogues of adenosylcobalamine in the dioldehydratase and methyl-malonyl-CoA mutase systems resulted in fundamental differences: Contrary to dioldehydratase the coenzyme activity remains in the methyl-malonyl-CoA mutase system when adenosyl-cobamides with a strongly modified nucleotide base are studied. The analogues give a good growth response with Escherichia coli. In the growth test with Lactobacillus leichmanii only the cobamides that do not have substituted nucleotide bases in the positions 2 or 3 of their imidazole ring are active.
authors.affiliation: Institut für Organische Chemie, Biochemie und Isotopenforschung der Universität Stuttgart.
authors.forename: G
authors.initials: G
authors.lastname: Eberhard
authors.forename: H
authors.initials: H
authors.lastname: Schlayer
authors.forename: H
authors.initials: H
authors.lastname: Joseph
authors.forename: E
authors.initials: E
authors.lastname: Fridrich
authors.forename: B
authors.initials: B
authors.lastname: Utz
authors.forename: O
authors.initials: O
authors.lastname: Müller
mesh_terms: D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D006836:Hydro-Lyases / Q000378:metabolism*; D007535:Isomerases / Q000378:metabolism*; D007700:Kinetics; D007778:Lactobacillus / Q000187:drug effects / Q000254:growth & development; D008765:Methylmalonyl-CoA Mutase / Q000378:metabolism*; D011408:Propanediol Dehydratase / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D006836:Hydro-Lyases; D011408:Propanediol Dehydratase; D007535:Isomerases; D008765:Methylmalonyl-CoA Mutase; D014805:Vitamin B 12
vernacular_title: Untersuchungen zur biologischen Funktion der Nucleotidbase von Vitamin B12.