title: Studies on the mechanism of salicylate-induced increase of insulin secretion in man.
abstract: Salicylate compounds are known to increase basal and stimulated insulin secretion in man. In our studies, infusion of lysine acetylsalicylate (72 mg/min) increased basal insulin levels and amplified insulin responses to glucose (5 g i.v.), arginine (5 g i.v.) and tolbutamide (1 g i.v.). Verapamil, an organic calcium antagonist, did not modify LAS-induced increase of basal insulin levels, but reduced the effect of LAS on glucose-induced insulin secretion. Calcitonin and somatostatin, two agents that inhibit basal and glucose-stimulated insulin secretion, inhibited the insulin response to glucose in presence of LAS infusion. The ability of salicylate compounds to augment insulin secretion might be due to multiple sites of action in the Beta-cells.
authors.affiliation: Cattedra di Diabetologia e Dietoterapia, Facoltà di Medicina, Università di Napoli, Italia.
authors.forename: D
authors.initials: D
authors.lastname: Giugliano
authors.forename: D
authors.initials: D
authors.lastname: Cozzolino
authors.forename: A
authors.initials: A
authors.lastname: Ceriello
authors.forename: T
authors.initials: T
authors.lastname: Cerciello
authors.forename: R
authors.initials: R
authors.lastname: Varano
authors.forename: F
authors.initials: F
authors.lastname: Saccomanno
authors.forename: R
authors.initials: R
authors.lastname: Torella
mesh_terms: D000328:Adult; D001120:Arginine / Q000494:pharmacology; D001241:Aspirin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002116:Calcitonin / Q000494:pharmacology; D005260:Female; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007700:Kinetics; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D012016:Reference Values; D013004:Somatostatin / Q000494:pharmacology; D014044:Tolbutamide / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
chemical_list: D007328:Insulin; D013004:Somatostatin; D002116:Calcitonin; D001120:Arginine; D014044:Tolbutamide; D014700:Verapamil; D005947:Glucose; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate