Resistance of helper T lymphocytes to cyclophosphamide.
The effect of cyclophosphamide (Cy) on helper T lymphocytes using an adoptive transfer approach in athymic nude mice was investigated. The results indicated that Cy, at a dose (100 mg/kg) which virtually abolished anti-sheep erythrocyte (SRBC) antibody plaque forming cell (PFC) response of Balb/c mice, did not alter significantly the capacity of their splenic T cells to restore the anti-SRBC PFC response of nude mice. This resistance of T helper cells was observed in unimmunized mice and in mice injected with SRBC two days prior to Cy administration. It has been concluded that both resting and antigen stimulated T helper cells responsible for reconstituting anti-SRBC response of nude mice are resistant to Cy.
Ghaffar
A
A
Sigel
M M
MM
Huggins
E M
EM
D000818:Animals; D001789:Blood Group Antigens / Q000276:immunology; D003520:Cyclophosphamide / Q000494:pharmacology*; D004351:Drug Resistance; D007113:Immunity, Innate / Q000187:drug effects; D007121:Immunocompetence / Q000187:drug effects*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects* / Q000276:immunology
D001789:Blood Group Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D003520:Cyclophosphamide