The role of sinusoidal stenoses in portal hypertension of liver cirrhosis.
To investigate the significance of sinusoidal stenoses in portal hypertension, liver cirrhosis was produced by feeding a choline-deficient diet for 6 months in rats, and hepatic haemodynamics were examined in the cirrhotic rats before and after feeding ordinary rat pellets for another 2 months. Feeding ordinary rat pellets led to the disappearance of fat droplets accumulated in the hepatocytes, normalization of the size of the swollen hepatocytes, and recovery from sinusoidal stenoses. As a result, increased sinusoidal vascular resistance and elevated portal vein pressure were reduced markedly, and clinical signs of portal hypertension, ascites and collateral blood circulation around the liver improved prominently. These facts suggest that sinusoidal stenoses lead to an increase in hepatic vascular resistance and portal hypertension.
Shibayama
Y
Y
Department of Pathology, Osaka Medical College, Japan.
Nakata
K
K
D000792:Angiography; D000818:Animals; D001794:Blood Pressure; D002796:Choline Deficiency / Q000150:complications; D003251:Constriction, Pathologic / Q000150:complications; D004032:Diet; D006503:Hepatic Veins / Q000473:pathology; D006975:Hypertension, Portal / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008099:Liver / Q000473:pathology / Q000503:physiopathology*; D008102:Liver Circulation; D008106:Liver Cirrhosis, Experimental / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D011169:Portal Vein / Q000000981:diagnostic imaging; D051381:Rats; D011919:Rats, Inbred Strains