Efficacy of triclabendazole against experimentally induced Fascioloides magna infections in sheep.
Efficacy of oral administration of 20 mg of triclabendazole/kg of body weight was evaluated against 12-week Fascioloides magna infections in 12 sheep, each inoculated orally with 250 viable metacercariae. From 6 sheep treated with triclabendazole, 1 immature F magna was recovered, whereas 116 F magna with a mean length of 19 +/- 6.5 mm were recovered from 6 untreated control sheep. Efficacy of triclabendazole was 99.14%. Signs of toxicosis or illness were not observed in the sheep.
Foreyt
W J
WJ
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D005212:Fasciolidae / Q000187:drug effects / Q000302:isolation & purification; D005213:Fascioloidiasis / Q000188:drug therapy*; D005260:Female; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D000077682:Triclabendazole
D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole