Rat atrial natriuretic polypeptide stimulation of adrenal zona glomerulosa cell growth.
Rat atrial natriuretic polypeptide (rANP) was found to stimulate [3H] thymidine incorporation into the DNA of bovine adrenal glomerulosa cells in a primary culture in a dose-dependent manner. The minimum effective dose was a very low concentration (10(-12) M of ANP), suggesting that ANP had a physiological effect. These findings are the first indication that ANP possesses growth-stimulating activity with regard to adrenal zona glomerulosa cells.
Horiba
N
N
Nomura
K
K
Saito
Y
Y
Demura
H
H
Shizume
K
K
D000302:Adrenal Cortex / Q000166:cytology*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D051381:Rats; D013936:Thymidine / Q000378:metabolism
D009320:Atrial Natriuretic Factor; D004247:DNA; D013936:Thymidine