title: Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only.
abstract: A total of 66.6% of Campylobacter pylori strains isolated from patients with peptic ulcers produced a cytotoxin active against mammalian cells in vitro, versus 30.1% of strains isolated from patients with chronic gastritis of various degrees of severity only. This difference was statistically significant and suggests that the toxic substance could be involved in the development of peptic ulcers.
authors.affiliation: Istituto di Malattie Infettive, Università di Siena, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Figura
authors.forename: P
authors.initials: P
authors.lastname: Guglielmetti
authors.forename: A
authors.initials: A
authors.lastname: Rossolini
authors.forename: A
authors.initials: A
authors.lastname: Barberi
authors.forename: G
authors.initials: G
authors.lastname: Cusi
authors.forename: R A
authors.initials: RA
authors.lastname: Musmanno
authors.forename: M
authors.initials: M
authors.lastname: Russi
authors.forename: S
authors.initials: S
authors.lastname: Quaranta
mesh_terms: D000818:Animals; D002167:Campylobacter / Q000472:pathogenicity*; D002169:Campylobacter Infections / Q000382:microbiology*; D002908:Chronic Disease; D003588:Cytopathogenic Effect, Viral; D003603:Cytotoxins / Q000096:biosynthesis*; D005756:Gastritis / Q000382:microbiology*; D006367:HeLa Cells; D006801:Humans; D010437:Peptic Ulcer / Q000382:microbiology*; D014709:Vero Cells
chemical_list: D003603:Cytotoxins