Central nervous system activity of terpenoids from marine sponge.
Some terpenoids extracted from marine sponge: triacetylated disidein, 2-tetraprenyl benzoquinol and 4 hydroxy-3-tetraprenylbenzoic acid 2-polyprenyl benzoquinols, avarol and furospongin-1 were tested by multidimensional Irwin screening and with some tests for analgesic and muscle relaxant activity. The three prenylhydroquinols derivatives and avarol show a good analgesic activity and low toxicity.
De Pasquale
R
R
Dipartimento Farmaco-Biologico, Università di Messina, Italy.
Circosta
C
C
Occhiuto
F
F
De Stefano
S
S
De Rosa
S
S
D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D002491:Central Nervous System Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003063:Cnidaria; D004353:Drug Evaluation, Preclinical; D051379:Mice; D009125:Muscle Relaxants, Central / Q000302:isolation & purification / Q000494:pharmacology; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology*
D000700:Analgesics; D002491:Central Nervous System Agents; D009125:Muscle Relaxants, Central; D013729:Terpenes