The role of hypothalamic hormones in the control of growth hormone secretion and of growth.
GHRH and somatostatin have major integrative roles in the control of GH secretion. Alterations in the secretion of each hypothalamic hormone have profound effects on GH secretion. On the basis of current information, it appears that disturbances in GHRH secretion provide a most convincing argument for the pathophysiological role of this hypothalamic hormone in clinically recognized disorders of GH secretion. Thus, the potential use of GHRH and its agonists and antagonists in the treatment of patients with both deficient and excessive GH secretion is based on a solid framework of physiological and pathophysiological studies.
Frohman
L A
LA
Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio.
D000818:Animals; D013006:Growth Hormone / Q000172:deficiency / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D007116:Immunization, Passive; D051379:Mice; D051381:Rats; D012756:Sheep; D013004:Somatostatin / Q000502:physiology*
D013004:Somatostatin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone