Distinction between metastatic melanoma and primary parotid gland carcinoma using monoclonal HMB 45 antimelanoma antibody: report of a case.
A case of malignant melanoma primary of the facial skin presenting with pre-auricular and submandibular masses, both thought to be metastatic melanoma, is reported. The case illustrates the practical application of a recently developed and commercially available specific anti-melanoma monoclonal antibody, HMB 45, which is useful in distinguishing between metastatic melanoma to a submaxillary lymph node and a synchronous primary parotid, poorly differentiated adenocarcinoma. The value of specific anti-melanoma antibody in conjunction with an antibody panel that includes S100, keratin, and epithelial membrane antigen in the distinction of melanomas from anaplastic carcinomas is discussed.
Podesta
A
A
Department of Pathology, Yale University School of Medicine, New Haven, CT.
Wagner-Reiss
K
K
Duray
P H
PH
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D002610:Cheek; D005153:Facial Neoplasms / Q000175:diagnosis* / Q000556:secondary; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000276:immunology / Q000556:secondary; D010307:Parotid Neoplasms / Q000175:diagnosis* / Q000473:pathology
D000911:Antibodies, Monoclonal