Intravenous self-administration of the indirect dopaminergic agonist amfonelic acid by rats.
The reinforcing properties of amfonelic acid, a nonamphetamine psychostimulant, were evaluated in an intravenous self-administration paradigm. Rats were trained to self-administer cocaine (0.5-3.0 mg/kg/infusion) on a fixed-ratio 10 schedule of reinforcement via surgically implanted intravenous catheters during daily 4-hr sessions. Substitution of amfonelic acid (0.0625-0.250 mg/kg/infusion) reliably maintained self-administration in a dose-dependent manner. These data indicate that amfonelic acid can act as a reinforcer in rats, and further suggest that amfonelic acid may have abuse potential in humans.
Porrino
L J
LJ
Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224.
Goodman
N L
NL
Sharpe
L G
LG
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009268:Nalidixic Acid / Q000031:analogs & derivatives; D009287:Naphthyridines / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D011917:Rats, Inbred Lew; D012646:Self Administration
D015259:Dopamine Agents; D009287:Naphthyridines; D009268:Nalidixic Acid; D003042:Cocaine; C006486:amfonelic acid