title: Detection of picogram levels of sufentanil by capillary gas chromatography.
abstract: Sufentanil and its two primary metabolites, N-(4-[methoxymethyl]-4-piperidinyl)-N-phenyl propanamide (MPPP), and N-(4[hydroxymethyl]-1-[2-thienylethyl]-4-piperidinyl)-N-phenyl propanamide (desmethyl sufentanil), were detected by capillary gas chromatography with a nitrogen-phosphorous detector. The detection limit for sufentanil and its metabolites is 30-50 pg/ml with minimal interfering substances in the chromatograms. This method allowed for the detection of serum sufentanil in the terminal elimination phase of sufentanil in a patient receiving 1.5 micrograms/kg and will allow for studies to determine the pharmacokinetics and metabolism of sufentanil in a wide variety of patient groups now receiving this agent.
authors.forename: S T
authors.initials: ST
authors.lastname: Weldon
authors.forename: D F
authors.initials: DF
authors.lastname: Perry
authors.forename: R C
authors.initials: RC
authors.lastname: Cork
authors.forename: A J
authors.initials: AJ
authors.lastname: Gandolfi
mesh_terms: D000328:Adult; D001711:Biotransformation; D002849:Chromatography, Gas; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000097:blood; D006801:Humans; D008297:Male; D008832:Microchemistry; D017409:Sufentanil / Q000031:analogs & derivatives
chemical_list: C047304:desmethylsufentanil; D017409:Sufentanil; C047303:noralfentanil; D005283:Fentanyl