[Present and future value of monoclonal antibodies in nephrology].
Many monoclonal antibodies directed against human T-lymphocytes have been produced in mice. Some of these, such as OKT 3, recognize all T-cells which can thus be counted in the blood; they have been used for the prevention of renal transplant rejection. Despite unexpected problems, such as antigenic modulation and anti-mouse sensitization, the first results obtained are promising. Other antibodies produced are directed against T-lymphocyte subsets, notably T-helpers (OKT4+) and T-suppressors or cytotoxic T-cells (OKT8+). Studies of the OKT4+/OKT8+ ratio have shown an imbalance in T-cell subsets in 2 types of glomerulonephritis: Berger's disease and membranous glomerulonephritis; they have also contributed to a better understanding of renal allograft rejection, where this ratio is often elevated.
Rothschild
E
E
Chatenoud
L
L
Bach
J F
JF
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D005921:Glomerulonephritis / Q000276:immunology; D006084:Graft Rejection / Q000187:drug effects; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology; D016030:Kidney Transplantation; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D051379:Mice; D009398:Nephrology / Q000379:methods*; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
D000911:Antibodies, Monoclonal
Intérêt présent et futur des anticorps monoclonaux en néphrologie.