Structural changes vary along individual arterioles in deoxycorticosterone acetate hypertensive rats.
The variability of structural changes along individual arterioles in deoxycorticosterone acetate (DOCA) hypertensive rats was measured by coefficients of variation of: (a) serial lumen diameters along microfil casts of individual mesenteric arterioles; and (b) wall and lumen indices in serial histological cross-sections along individual renal arterioles. The mean lumen diameter of third-order mesenteric arterioles decreased with increasing duration of hypertension. There was increased variability of lumen diameter along lengths of DOCA arterioles, the coefficient of variation at 10 weeks DOCA treatment being 20.2 +/- 0.6% compared to 9.2 +/- 0.2% in controls (P less than 0.001). Medial area to internal elastic lamina (IEL) radius ratio of renal arterioles was increased in DOCA rats compared with control rats (P less than 0.025) and its variability along individual arterioles expressed as the coefficient of variation was 31.70 +/- 3.87% in DOCA rats compared with 15.29 +/- 1.72% in controls (P less than 0.005). The observed increase in variability of lumen diameter and medial area along short lengths of individual arterioles in DOCA hypertensive rats indicates that hypertensive structural changes are probably not directly related to local blood pressure. We suggest that irregular functional vasoconstriction in hypertensive rats could account for this distribution of structural changes.
Vial
J H
JH
Department of Medicine, Clinical School, University of Tasmania, Hobart, Australia.
Yong
A C
AC
Walker
M B
MB
Boyd
G W
GW
D000818:Animals; D001160:Arterioles / Q000187:drug effects; D003900:Desoxycorticosterone / Q000633:toxicity*; D006973:Hypertension / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012077:Renal Artery / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects
D003900:Desoxycorticosterone