Fragmented sleep, daytime somnolence and age in narcolepsy.
This study examined whether narcoleptics experience an age-related increase in nocturnal sleep disturbance and, if so, what impact that disturbance has on daytime sleepiness. To evaluate these questions, the records of 228 patients diagnosed as narcoleptic were assessed. Total sleep time (TST) and sleep efficiency (SE) significantly decreased, and wake during sleep (WDS), number of awakenings, and percentage of stage one significantly increased across the decades. This indicates an age-related elevation in sleep fragmentation. Daytime sleepiness, however, did not exhibit age effects. These data further support the theory that narcolepsy is a basic neural defect not confounded by excessive daytime sleepiness secondary to sleep fragmentation.
Lamphere
J
J
Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan 48202.
Young
D
D
Roehrs
T
T
Wittig
R M
RM
Zorick
F
F
Roth
T
T
D000328:Adult; D000375:Aging / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D009290:Narcolepsy / Q000503:physiopathology*; D012890:Sleep / Q000502:physiology*