Acute nonlymphocytic leukemia (M2) with chromosome abnormality trisomy 4 developing eight years after radiation therapy for breast cancer.
We report here the development, 8 years after radiation therapy for breast cancer, of acute nonlymphocytic leukemia (ANLL), type M2 of the FAB classification, in which trisomy 4 was detected as the only chromosomal abnormality. Simultaneous observation of cytologic and cytogenetic features of individual colonies derived from leukemic progenitor (L-CFU) and early progenitor (CFU mix) cultures in this patient revealed that all colonies examined had a normal karyotype, although the clone with trisomy 4 was predominant in the direct bone-marrow culture. These findings suggest that progenitor cells with trisomy 4 were less predominant in colony growth when stimulated by colony-stimulating factors (CSFs) than were stem cells with a normal karyotype.
Yokota
S
S
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
Taniwaki
M
M
Okuda
T
T
Maekawa
T
T
Nishida
K
K
Misawa
S
S
Takino
T
T
Abe
T
T
Urata
Y
Y
D001943:Breast Neoplasms / Q000150:complications / Q000532:radiotherapy*; D002894:Chromosomes, Human, Pair 4; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D007953:Leukemia, Radiation-Induced / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D014314:Trisomy; D014410:Tumor Stem Cell Assay