Hyal-1, a locus determining serum hyaluronidase polymorphism, on chromosome 9 in mice.
Analysis of mouse serum hyaluronidase by polyacrylamide gel electrophoresis, with the substrate high-molecular-weight hyaluronan (hyaluronic acid) included in the gel performed in mice of two different strains, BALB/cBy and C57BL/6By, reveals a pattern of multiple enzyme forms specific for each genotype. In BALB/c serum, seven different forms are present, only one of which is found in C57BL/6 serum. Segregation analysis of the enzyme polymorphism in backcross progeny and in recombinant inbred and bilineal congenic lines shows that the difference is due to a single locus, which we have designated as Hyal-1. Hyal-1 is linked to the histocompatibility locus H-7, on chromosome 9.
Fiszer-Szafarz
B
B
Institut Curie-Biologie, Centre Universitaire, Orsay, France.
De Maeyer
E
E
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005796:Genes; D005838:Genotype; D006821:Hyaluronoglucosaminidase / Q000097:blood / Q000235:genetics*; D007527:Isoenzymes / Q000097:blood / Q000235:genetics*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008970:Molecular Weight
D007527:Isoenzymes; D006821:Hyaluronoglucosaminidase