The human homologues of Fim1, Fim2/c-Fms, and Fim3, three retroviral integration regions involved in mouse myeloblastic leukemias, are respectively located on chromosomes 6p23, 5q33, and 3q27.
Three mouse genomic domains, Fim1, Fim2, and Fim3, were previously described as proviral integration regions frequently involved in the early stages of myeloblastic leukemogenesis induced in vivo or in vitro by the Friend murine leukemia virus. Fim2 was identified as the 5' end of the c-Fms protooncogene, which encodes the receptor of the macrophage colony stimulating factor (Csflr). The functions of Fim1 and Fim3 are not yet known, but these regions are highly conserved among different species. To examine whether these regions could correspond to known human loci involved in genetic alterations specific to some human leukemias, we undertook their chromosomal mapping. The localization of FIM2/c-FMS on 5q33 was confirmed. FIM1 and FIM3 were localized on human chromosomes 6p22.3-p23 and 3q27 respectively. Interestingly, translocations involving these two regions have been described in various hematopoietic malignancies: the t(6;9)(p23;q34) in acute nonlymphocytic leukemias and the 3q26-q28 translocations in a large variety of leukemias.
Van Cong
N
N
Clinique et Unité de Recherches de Génétique Médicale (INSERM U.12), Hôpital des Enfants-Malades, Paris, France.
Fichelson
S
S
Gross
M S
MS
Sola
B
B
Bordereaux
D
D
de Tand
M F
MF
Guilhot
S
S
Gisselbrecht
S
S
Frézal
J
J
Tambourin
P
P
D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D002895:Chromosomes, Human, Pair 5; D002896:Chromosomes, Human, Pair 6; D005622:Friend murine leukemia virus / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007942:Leukemia, Experimental / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D051379:Mice; D011519:Proto-Oncogenes; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid; D014407:Tumor Cells, Cultured
D005819:Genetic Markers