Effect of nonspecific immune stimulation with BCG and polidin on the Ehrlich ascites tumor growth.
Investigations were performed to study: 1) the antitumor effect of BCG pretreatment on the development of Ehrlich ascites tumor in mice; 2) the effect of BCG administration in relation to the period of time before tumor inoculation and the dose levels used, and 3) the antitumor effect of an associated pretreatment of BCG and Polidin on the development of Ehrlich ascites tumor. BCG administered prior to Ehrlich ascites tumor inoculation have a protective effect evidenced by a delay in tumor development, a prolonged survival of the tumor host and, in some cases, even inhibition of tumor growth. The effect of BCG was highly dependent on 1) the dose and the time of administration of BCG and) 2 the combined pretreatment of BCG and Polidin.
Todoruţiu-Papilian
C
C
Daicoviciu
D
D
Mulea
R
R
Rişcă
R
R
D000276:Adjuvants, Immunologic / Q000276:immunology; D000818:Animals; D001500:BCG Vaccine; D001419:Bacteria; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology* / Q000517:prevention & control; D005260:Female; D051379:Mice; D009368:Neoplasm Transplantation
D000276:Adjuvants, Immunologic; D001500:BCG Vaccine