Modeling of the homoeo domain suggests similar structure to repressors.
The sequences of the homoeo domain containing the three alpha-helices were modeled based on secondary structure prediction, sequence homologies and coordinates of known helix-turn-helix motif containing DNA-binding proteins. The model reveals very similar three dimensional structure to repressors and suggest binding to DNA with its helix 3.
Tsonis
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PA
VA Medical Center, Indiana University, Indianapolis 46202.
Carperos
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V
Siahaan
T
T
Shiahaan
T
T
D000595:Amino Acid Sequence; D003198:Computer Simulation; D004268:DNA-Binding Proteins / Q000648:ultrastructure*; D005801:Genes, Homeobox; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012097:Repressor Proteins; D013329:Structure-Activity Relationship
D004268:DNA-Binding Proteins; D012097:Repressor Proteins