[Hemostasis in cancer patients during radiation therapy using metronidazole].
Indices of platelet function, plasmic coagulation and fibrinolysis were studied during gamma-beam therapy in patients with laryngeal, gastric and cervical tumors (potentially at risk for thrombosis) against a background of metronidazole administration. During the above therapy the thrombophilic status of gastric cancer patients was preserved. These patients were considered at risk for thrombosis. In patients with laryngeal and cervical cancer platelet capacity to adhesion was considerably reduced during radiotherapy with the use of metronidazole. As a result of it the thrombogenic blood potential and danger of intravascular thrombogenesis were decreased.
Chekalina
S I
SI
Berdov
B A
BA
Pavlov
V V
VV
Andreev
V G
VG
D003131:Combined Modality Therapy; D005260:Female; D006487:Hemostasis / Q000187:drug effects / Q000528:radiation effects*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood / Q000150:complications / Q000628:therapy*; D008795:Metronidazole / Q000627:therapeutic use*; D011300:Preoperative Care; D011879:Radiotherapy Dosage; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000097:blood / Q000150:complications / Q000628:therapy*; D013927:Thrombosis / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000150:complications / Q000628:therapy*
D008795:Metronidazole
Gemostaz onkologicheskikh bol'nykh v protsesse luchevoĭ terapii s primeneniem metronidazola.