Excretion of penicillins and cephalexin in bovine milk following intramammary administration.
The elimination into bovine milk of beta-lactam antibiotic residues (procaine penicillin G, cloxacillin, ampicillin, oxacillin, cephalexin) following intramammary administration of 10 preparations marketed in France was studied. The quantitative analysis of residues was carried out by a microbiological agar diffusion method using Bacillus stearothermophilus. Sensitivity ranged from 0.001 I.U./ml for procaine penicillin G and 0.001 micrograms/ml for ampicillin to 0.02 micrograms/ml for cephalexin. The mean periods of elimination on which withholding times are based were between four and seven milkings according to the drugs administered.
Moretain
J P
JP
Ministère de l'Agriculture, Laboratoire National des Médicaments Vétérinaires, Fougères, France.
Boisseau
J
J
D000362:Agar; D000667:Ampicillin / Q000493:pharmacokinetics; D000818:Animals; D002417:Cattle; D002506:Cephalexin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003023:Cloxacillin / Q000493:pharmacokinetics; D004058:Diffusion; D005260:Female; D007700:Kinetics; D008321:Mammary Glands, Animal; D008892:Milk / Q000378:metabolism*; D010068:Oxacillin / Q000493:pharmacokinetics; D010402:Penicillin G Procaine / Q000493:pharmacokinetics; D010406:Penicillins / Q000008:administration & dosage / Q000493:pharmacokinetics*
D010406:Penicillins; D010402:Penicillin G Procaine; D000667:Ampicillin; D000362:Agar; D003023:Cloxacillin; D002506:Cephalexin; D010068:Oxacillin