title: High-performance liquid chromatographic determination of trimethoprim in serum.
abstract: A procedure for determining trimethoprim in serum is reported. It employs the same high-performance liquid chromatographic system described previously for measurement of anticonvulsants, barbiturates, theophylline, caffeine, acetaminophen, and chloramphenicol in serum. The sample preparation for trimethoprim is nearly identical. As a method extension, quantitation of serum trimethoprim on clinical specimens can be easily accommodated as required.
authors.affiliation: Department of Clinical Biochemistry, St. Boniface General Hospital, Winnipeg, Manitoba, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Meatherall
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006801:Humans; D014295:Trimethoprim / Q000031:analogs & derivatives / Q000097:blood* / Q000378:metabolism
chemical_list: D014295:Trimethoprim