Early human decidual cells exhibit NK activity against the K562 cell line but not against first trimester trophoblast.
The susceptibility of cultured first trimester human trophoblast cells to lysis by NK cells has been studied. Trophoblast cells are resistant to lysis by NK cells from both peripheral blood and decidua. However, decidual cells extracted by enzymatic disaggregation do exhibit cytotoxicity against the NK-sensitive cell line K562. The relevance of these findings to successful implantation of the blastocyst is discussed.
King
A
A
Department of Pathology, University of Cambridge, United Kingdom.
Birkby
C
C
Loke
Y W
YW
D002469:Cell Separation; D003602:Cytotoxicity, Immunologic; D003656:Decidua / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000276:immunology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D014327:Trophoblasts / Q000276:immunology*