Involvement of peripheral dopaminergic mechanisms in the action of a 2-piperazinotetralin (P-11) with hypotensive activity.
The piperazinotetralin derivative P-11 applied in increasing concentrations (10(-12) to 10(-4)M) inhibited field electrical stimulation-induced contractions of isolated rabbit ear artery and this effect was not reversed by S-sulpiride (10(-6)M). This was probably due to the postsynaptic alpha receptor-blocking action of P-11. The compound also did not modify PGF2 alpha-induced contractions of isolated rabbit renal artery, suggesting the lack of action of P-11 on postsynaptic DA1 receptors. The lack of activity of P-11 on DA1 and DA2 peripheral receptors was associated with the chemical structure of the compound.
Mutafova-Yambolieva
V
V
Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia.
Staneva-Stoytcheva
D
D
D015081:2-Naphthylamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D015237:Dinoprost / Q000378:metabolism; D004558:Electric Stimulation; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009281:Naphthalenes / Q000494:pharmacology*; D011817:Rabbits; D011954:Receptors, Dopamine / Q000187:drug effects*; D013469:Sulpiride / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D009281:Naphthalenes; D011954:Receptors, Dopamine; C023611:N-(3-hydroxy-1,2,3,4-tetrahydro-2-naphthyl)-N-(3-oxo-3-phenyl-2-methylpropyl)piperazine; D013469:Sulpiride; D015237:Dinoprost; D015081:2-Naphthylamine