Nephrotic syndrome: a platelet hyperaggregability state.
Nephrotic syndrome characterized by hypoalbuminemia and hyperlipidemia is associated with an increased incidence of thromboembolism and increased platelet hyperaggregability. Although plasma coagulation proteins are also abnormal, changes are too inconsistent to attribute thromboembolic complications to the coagulation cascade alone. Antithrombin III (ATIII) has been shown to be deficient in nephrotic syndrome. There is, however, an increase in alpha 2 macroglobulin. It is clear that platelet to platelet interactions require exposure of platelet fibrinogen receptors, the binding of fibrinogen to these receptors, platelet crossbridging, and subsequent platelet aggregation. Fibrinogen is consistently elevated in nephrotic syndrome. Hyperlipidemia and hypoalbuminemia in nephrotic syndrome increases the availability of thromboxane A2 (TxA2) by increasing the availability of TxA2 precursors and the removal of TxA2 inhibitors. Thromboxane A2 is a known inducer of platelet aggregation probably through the exposure of platelet fibrinogen receptors. Recently, fibronectins a group of adhesive proteins, were implicated in platelet to platelet interactions. Since thrombin increases the expression of platelet surface fibronectin, fibronectin may be involved in thrombus formation in nephrotic syndrome. Thromboembolic formation in nephrotic syndrome is a composite mechanism involving the coagulation cascade, platelet-platelet interactions, and platelet-surface interactions.
Rasedee
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A
Feldman
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BF
D001792:Blood Platelets / Q000502:physiology; D011464:Epoprostenol / Q000502:physiology; D005340:Fibrinogen / Q000502:physiology; D005353:Fibronectins / Q000502:physiology; D006801:Humans; D009404:Nephrotic Syndrome / Q000097:blood*; D010974:Platelet Aggregation; D010978:Platelet Factor 4 / Q000502:physiology; D013923:Thromboembolism / Q000209:etiology*; D013928:Thromboxane A2 / Q000502:physiology; D001620:beta-Thromboglobulin / Q000502:physiology
D005353:Fibronectins; D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; D013928:Thromboxane A2; D005340:Fibrinogen; D011464:Epoprostenol