Increased efficacy and toxicity of lidocaine in patients on beta-blockers.
The greatest differences in ventricular arrhythmias and adverse effects of lidocaine observed in this study were between patients on both lidocaine and a beta-adrenoceptor blocking agent and those on neither drug. Although free fractions of lidocaine and methylglycylxylidine tended to be higher in patients on beta-adrenoceptor blocking agents, this difference was not significant nor were any other differences in serum drug levels observed.
Wyse
D G
DG
Department of Medicine (Division of Cardiology), Faculty of Medicine, University of Calgary, Alberta, Canada.
Kellen
J
J
Tam
Y
Y
Rademaker
A W
AW
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D009961:Orosomucoid / Q000378:metabolism; D011897:Random Allocation
D000319:Adrenergic beta-Antagonists; D009961:Orosomucoid; D008012:Lidocaine