A new parenteral emulsion for the administration of taxol.
Taxol (NSC-125973) is a poorly soluble plant product that exhibits excellent antimitotic properties. This study involves the development of a new formulation for taxol. The stability of taxol in a 50% triacetin emulsion as well as possible methods of intravenous administration of this dosage form was examined. A stable emulsion was found at taxol concentrations of 10 and 15 mg/ml of emulsion. The 50% triacetin emulsion showed an intravenous LD50 of 1.2 ml/kg in Swiss-Webster mice. The 10 mg/ml taxol formulation was demonstrated to be stable upon addition to 5% dextrose iv fluids provided that small packing systems were used. The taxol-triacetin emulsion can also be intravenously injected at various rates, and it may prove to be a useful formulation for taxol.
Tarr
B D
BD
Department of Pharmaceutical Sciences, University of Arizona, Tucson 85721.
Sambandan
T G
TG
Yalkowsky
S H
SH
D000470:Alkaloids / Q000008:administration & dosage* / Q000633:toxicity; D000818:Animals; D002626:Chemistry, Pharmaceutical; D004655:Emulsions; D006461:Hemolysis; D007263:Infusions, Parenteral; D051379:Mice; D017239:Paclitaxel; D014677:Pharmaceutical Vehicles; D014215:Triacetin / Q000633:toxicity; D014280:Triglycerides / Q000633:toxicity
D000470:Alkaloids; D004655:Emulsions; D014677:Pharmaceutical Vehicles; D014280:Triglycerides; D017239:Paclitaxel; D014215:Triacetin