[Plasma digoxin levels following treatment with metaclazepam].
Nine cardiac patients treated with digitalis participated in a 3-week study with the aim to investigate whether digoxin (beta-acetyldigoxin) interacts with the new 1,4-benzodiazepine metaclazepam. Comparison of the plasma digoxin levels under placebo and metaclazepam treatment showed no statistically significant differences, i.e. no interactions between digoxin and metaclazepam were found.
Völker
D
D
Sonnenhof-Klinik, Bad Oeynhausen.
Müller
R
R
Günther
C
C
Bode
R
R
D000368:Aged; D000369:Aged, 80 and over; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D004077:Digoxin / Q000097:blood* / Q000493:pharmacokinetics; D004347:Drug Interactions; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D004077:Digoxin; C036366:metaclazepam
Digoxin-Plasmaspiegel während der Behandlung mit Metaclazepam.