Investigations on the opsonin-dependent interaction of Klebsiella bacteria and human polymorphonuclear leukocytes.
Encapsulated and nonencapsulated Klebsiella strains with different types of fimbriation were tested for their opsonin-dependent stimulation of human polymorphonuclear leukocytes (PMNs). Chemiluminescence (CL) of the PMNs was determined since CL-response can be used indirectly to quantitate phagocytosis. Apparently, the interaction between Klebsiella bacteria and human PMNs is dependent on the type of fimbration and on the presence of capsules. Evaluation of the bactericidal capacity of human PMNs against Klebsiella bacteria positively correlated with the chemiluminescence response demonstrating the importance of fimbriation and capsulation for this process, too.
Przondo-Mordarska
A
A
Microbiological Department, Medical Academy, Wroclaw, Poland.
Ko
H L
HL
Matej-Melczynska
M
M
Beuth
J
J
Roszkowski
W
W
Pulverer
G
G
D001422:Bacterial Adhesion; D010861:Fimbriae, Bacterial / Q000276:immunology; D006801:Humans; D007709:Klebsiella / Q000276:immunology* / Q000648:ultrastructure; D008163:Luminescent Measurements; D009504:Neutrophils / Q000276:immunology*; D009895:Opsonin Proteins / Q000276:immunology*; D010587:Phagocytosis
D009895:Opsonin Proteins