title: Propranolol does not alter cerebral blood flow and functions in cirrhotic patients without previous hepatic encephalopathy.
abstract: Since it has been suggested that propranolol could lead to hepatic encephalopathy, we undertook a study to assess the effects of propranolol on cerebral blood flow and cerebral functions. Sixteen patients with alcoholic cirrhosis and large esophageal varices and without major hepatic dysfunction (Child-Pugh score less than 14) or previous hepatic encephalopathy were randomized to receive either propranolol or placebo. The following measurements were performed before and 15 min after single intravenous administration of 15 mg propranolol or placebo and again 1 week after chronic oral administration of propranolol 160 mg per day or placebo: cerebral blood flow by the xenon-133 inhalation technique, quantitative electroencephalogram, psychometric test (number connection test), arterial ammonia, pH and pCO2, resting and exercise heart rates (after single administration, electroencephalogram, number connection test and biochemical measurements were not performed). Cerebral blood flow was not significantly modified by treatment (propranolol group: 80 +/- 23 vs. 76 +/- 11 and 83 +/- 9; placebo group: 73 +/- 10 vs. 75 +/- 11 and 81 +/- 18 ml per 100 gm per min, respectively, before and after single and repeated administration). Likewise, neither of the two treatments significantly altered number connection test, quantitative electroencephalogram index, arterial ammonia, pH and pCO2. We conclude that, in this population of cirrhotic patients, propranolol did not alter cerebral blood flow or neuropsychological functions. As a consequence, hemodynamic alterations cannot be considered as causes of possible cerebral side effects of propranolol in cirrhotic patients without severe hepatic dysfunction and previous hepatic encephalopathy.
authors.affiliation: Service d'Hépato-Gastroentérologie, Hôpital Purpan, Toulouse, France.
authors.forename: P
authors.initials: P
authors.lastname: Calès
authors.forename: M
authors.initials: M
authors.lastname: Pierre-Nicolas
authors.forename: A
authors.initials: A
authors.lastname: Guell
authors.forename: J L
authors.initials: JL
authors.lastname: Mauroux
authors.forename: A
authors.initials: A
authors.lastname: Franco-Sempe
authors.forename: J P
authors.initials: JP
authors.lastname: Vinel
authors.forename: G
authors.initials: G
authors.lastname: Geraud
authors.forename: J P
authors.initials: JP
authors.lastname: Pascal
mesh_terms: D000641:Ammonia / Q000097:blood; D001921:Brain / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D015444:Exercise; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000503:physiopathology*; D011433:Propranolol / Q000494:pharmacology*; D012146:Rest; D012720:Severity of Illness Index
chemical_list: D000641:Ammonia; D011433:Propranolol