title: Rat atrial natriuretic polypeptide stimulation of adrenal zona glomerulosa cell growth.
abstract: Rat atrial natriuretic polypeptide (rANP) was found to stimulate [3H] thymidine incorporation into the DNA of bovine adrenal glomerulosa cells in a primary culture in a dose-dependent manner. The minimum effective dose was a very low concentration (10(-12) M of ANP), suggesting that ANP had a physiological effect. These findings are the first indication that ANP possesses growth-stimulating activity with regard to adrenal zona glomerulosa cells.
authors.forename: N
authors.initials: N
authors.lastname: Horiba
authors.forename: K
authors.initials: K
authors.lastname: Nomura
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Demura
authors.forename: K
authors.initials: K
authors.lastname: Shizume
mesh_terms: D000302:Adrenal Cortex / Q000166:cytology*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D051381:Rats; D013936:Thymidine / Q000378:metabolism
chemical_list: D009320:Atrial Natriuretic Factor; D004247:DNA; D013936:Thymidine