Neurons from substantia nigra increase the efficacy and potency of second messenger arising from striatal astroglia dopamine receptor.
Dopamine (D1) receptors were demonstrated to be present on astroglial cells from striatum in primary culture. In a cocultivation system, the astrocytes were influenced by neurons from one of their natural projection areas (substantia nigra) to increase the efficacy and potency of second messenger (cyclic AMP) from the dopamine receptor. This provides evidence for a heterogeneity among astroglia from the various brain regions with respect to the expression of receptors.
Hansson
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E
Institute of Neurobiology, University of Göteborg, Sweden.
Rönnbäck
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L
D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D001552:Benzazepines / Q000494:pharmacology; D002450:Cell Communication; D002478:Cells, Cultured; D003342:Corpus Striatum / Q000166:cytology / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D018818:Fenoldopam; D009474:Neurons / Q000502:physiology; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D015290:Second Messenger Systems / Q000187:drug effects; D013378:Substantia Nigra / Q000166:cytology / Q000502:physiology
D001552:Benzazepines; D011954:Receptors, Dopamine; D000242:Cyclic AMP; D018818:Fenoldopam