Antivasodepressor action of antihistaminics determined ex vivo in the leg blood vessels of anaphylactic mice and rats.
In anaphylactic mice and rats vasodepression determined ex vivo in the isolated perfused hindlegs can partly be prevented by pretreatment of the animals with promethazine, cyproheptadine, astemizole, clemastine, cimetidine, and some of their combinations. Astemizole and clemastine were most active. However, there was no complete protection against vasodepression, indicating vasodepression mediators others than histamine to be involved in the development of vasodepression.
Bekemeier
H
H
Department of Pharmacology, Martin Luther University Halle-Wittenberg, GDR.
Hänsel
F
F
Sänze
J U
JU
D000707:Anaphylaxis; D000818:Animals; D004487:Edema; D005260:Female; D006614:Hindlimb / Q000098:blood supply; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009132:Muscles / Q000098:blood supply*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012039:Regional Blood Flow / Q000187:drug effects
D006634:Histamine H1 Antagonists