Decline in cycling of granulocyte-macrophage colony-forming cells with increasing age in mice.
The cycling state of granulocyte-macrophage progenitor cells (GM-CFC) was measured using the [3H]thymidine suicide technique in individual male B6D2F1 mice. The proportion of the GM-CFC population in S phase was found to decrease from 25%-35% at 1-6 months of age to about 10% in mice greater than 2 years old.
Tejero
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C
Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, England.
Testa
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Hendry
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D000375:Aging / Q000502:physiology*; D000818:Animals; D001854:Bone Marrow Cells; D002453:Cell Cycle; D002478:Cells, Cultured; D006098:Granulocytes; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D008264:Macrophages; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL