Reduction of intestinal carcinogen absorption by carcinogen-specific secretory immunity.
A secretory immune response to the carcinogen 2-acetylaminofluorene (AAF) was elicited in rabbits by directly immunizing the small intestine with an AAF-cholera toxin conjugate. High-titer, high-affinity secretory immunoglobulin A (IgA) antibody to AAF was secreted into the intestinal lumen in response to this immunogen. Immune secretions reduced the transepithelial absorption of a 125I-labeled derivative of AAF by more than half. This reduction of absorption by hapten-specific IgA suggests that oral vaccines against carcinogens and toxicants could be developed for humans.
Silbart
L K
LK
University of Michigan, Pathology Department, Ann Arbor, MI 48109.
Keren
D F
DF
D015073:2-Acetylaminofluorene / Q000276:immunology / Q000378:metabolism* / Q000493:pharmacokinetics; D000818:Animals; D007116:Immunization, Passive; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis*; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000276:immunology*; D011817:Rabbits
D007071:Immunoglobulin A, Secretory; D015073:2-Acetylaminofluorene