title: Treatment of vaginal intraepithelial neoplasia with laser and topical 5-fluorouracil.
abstract: The records of 59 women with grades 2 and 3 vaginal intraepithelial neoplasia were reviewed to define the role of CO2 laser ablation and topical 5-fluorouracil (5-FU) in the treatment of vaginal intraepithelial neoplasia. The patients in each treatment group were comparable in their personal characteristics and in distribution and severity of the lesions. Thirty-one patients used prophylactic 5-FU. Seventy-eight percent of all patients were free of vaginal intraepithelial neoplasia at the first follow-up examination. The results of treatment were not influenced by the grade of the lesion or previous radiation exposure of the patient. Topical 5-FU appeared to be as effective as laser. Periodic applications of 5-FU (once weekly for 10 weeks) were as effective as 5-FU applied in a continuous fashion (three 7-day courses 1 week apart), and caused fewer side effects.
authors.affiliation: Department of Obstetrics and Gynecology, Medical College of Virginia, Richmond.
authors.forename: H B
authors.initials: HB
authors.lastname: Krebs
mesh_terms: D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D053685:Laser Therapy; D008875:Middle Aged; D014625:Vaginal Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*
chemical_list: D005472:Fluorouracil