title: [Treatment of amyloidosis with dimethyl sulfoxide (DMSO)].
abstract: In this study we have investigated the role of oral dimethylsulfoxide (DMSO) therapy in 2 patients with primary amyloidosis (AL) and in 2 patients with secondary amyloidosis (AA) to long-standing rheumatoid arthritis. DMSO treatment produced no beneficial effects in the patients with idiopathic amyloidosis. Instead the patients with secondary amyloidosis experienced a subjective improvement, a decrease of inflammatory activity of the rheumatoid arthritis and an unequivocal improvement of renal function following 3-6 months of DMSO therapy. No serious side effects of DMSO were observed except for unpleasant breath odour. We conclude that a treatment with oral DMSO may prolong life of patients with secondary amyloidosis.
authors.affiliation: Ospedale di Cattinara, Trieste.
authors.forename: P
authors.initials: P
authors.lastname: Morassi
authors.forename: F
authors.initials: F
authors.lastname: Massa
authors.forename: E
authors.initials: E
authors.lastname: Mesesnel
authors.forename: D
authors.initials: D
authors.lastname: Magris
authors.forename: B
authors.initials: B
authors.lastname: D'Agnolo
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000686:Amyloidosis / Q000188:drug therapy* / Q000209:etiology; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy; D002908:Chronic Disease; D004121:Dimethyl Sulfoxide / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006209:Halitosis / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D004121:Dimethyl Sulfoxide
vernacular_title: Trattamento dell'amiloidosi con dimetilsulfossido (DMSO).