title: Functional outcome after delivery of intrathecal baclofen.
abstract: Patients with multiple sclerosis or spinal cord injury often have severe, disabling spasticity. This is frequently treated with oral medications or with destructive neurosurgical procedures. We report on a group of patients with spasticity not relieved by these methods. These patients were subsequently treated with intrathecal baclofen delivered by an implanted programmable drug pump. Twenty-one patients have received this form of treatment, and the functional status of eight has been tracked by the Patient Evaluation Conference System (PECS) for at least six months. In most cases, spasticity, performance of bowel and bladder programs, and performance of ADL improved after delivery of intrathecal baclofen. The improvements appear to be due to the decrease in hypertonicity and the increased ease of movement (passive or active) in affected extremities. Intrathecal baclofen should be considered as a treatment method in patients with severe spasticity of spinal origin.
authors.affiliation: Department of Rehabilitation Medicine, Rush Medical College, Chicago, IL 60612.
authors.forename: B
authors.initials: B
authors.lastname: Parke
authors.forename: R D
authors.initials: RD
authors.lastname: Penn
authors.forename: S M
authors.initials: SM
authors.lastname: Savoy
authors.forename: D
authors.initials: D
authors.lastname: Corcos
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D001418:Baclofen / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D011446:Prospective Studies; D013119:Spinal Cord Injuries / Q000150:complications
chemical_list: D001418:Baclofen