Induction of sister chromatid exchanges by ergot compounds in Chinese hamster ovary cells in vitro.
Five ergot alkaloids, d-lysergic acid derivatives, were tested for the induction of sister chromatid exchange (SCE) frequencies in cultured Chinese hamster ovary cells. The concentrations of the test substances ranged between 10(-5) and 10(-8) M. Ergotamine, ergonovine, and methylergonovine induced a significantly high number of SCEs at all the concentrations used, while with ergocristine this occurred only at the highest concentration. alpha-Ergocryptine failed to induce SCEs at any concentration. It is therefore surmised that ergotamine, ergonovine, and methylergonovine are effective inducers, ergocristine is a weak inducer, and alpha-ergocryptine is a noninducer in Chinese hamster ovary cells in vitro.
Dighe
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Department of Zoology, M.A.C.S. Research Institute, Pune, India.
Vaidya
V G
VG
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004876:Ergot Alkaloids / Q000494:pharmacology*; D005260:Female; D008938:Mitosis / Q000187:drug effects; D010053:Ovary; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013329:Structure-Activity Relationship
D004876:Ergot Alkaloids