[Characteristics of the membranes and functional activity of phagocytic alveolar macrophages].
Alveolar macrophages (AM) accumulate products of lipid peroxidation (PLP) in the time of phagocytosis of zymosan particles (ZP) during 4 hours, that lead to increase of lipid viscosity and decrease surface membrane area, which were studied by fluorescent probes pyrene and HSPH-14. Preliminary stimulation of AM by i/v ZP-injection of A(100 mg/kg before 5 days) lead to a decrease of lipid membrane viscosity and intensification of AM functional activity. During phagocytosis of ZP experimental cells accumulate much less PLP, than control cells, and promote support of viscosity on a more low level, and functional activity (phagocytic, adhesion properties)--on more high level, than in control cells.
Kolosova
N G
NG
Shishkina
L N
LN
D000818:Animals; D005456:Fluorescent Dyes; D015227:Lipid Peroxidation; D008264:Macrophages / Q000502:physiology*; D008563:Membrane Lipids / Q000032:analysis; D008566:Membranes / Q000032:analysis; D010587:Phagocytosis; D051381:Rats; D014783:Viscosity; D015054:Zymosan
D005456:Fluorescent Dyes; D008563:Membrane Lipids; D015054:Zymosan
Kharakteristika membran i funktsional'noĭ aktivnosti fagotsitiruiushchikh al'veoliarnykh makrofagov.