[Effect of hemosorption on the dynamics of immunopathologic changes in the skin of patients with diseases accompanying the immune complex syndrome].
In the majority of diseases with the immune complexes (IC) syndrome, elimination of IC from the body is markedly disturbed. The authors carried out a study with the aid of the direct immunofluorsecence technique. The use of hemosorption in the treatment of patients with grave patterns of systemic lupus erythematosus, rheumatoid arthritis, psoriasis, systemic vasculitis and similar illnesses in conjunction with conventional therapy (corticosteroids, cytostatics) leads to sequestration of the depositions of immune complexes from the skin. As early as after the first hemosorption one can observe the displacement of IC from the derma to the epidermis, advance of IC towards the stratum corneum. After the third session in hemosorption IC granules appear on the body surface, in the form of warty formulations which are removed afterwards together with skin scales. It is assumed that hemosorption recovers the secretory function of the skin, aimed at IC elimination.
Dmitriev
A A
AA
Beletskaia
L V
LV
Bektimirov
R A
RA
Mudrenko
I Iu
IIu
Bukhova
V P
VP
D000974:Antibodies, Antinuclear / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000628:therapy; D006464:Hemoperfusion; D006801:Humans; D007105:Immune Complex Diseases / Q000628:therapy*; D008180:Lupus Erythematosus, Systemic / Q000628:therapy; D011565:Psoriasis / Q000628:therapy; D012867:Skin / Q000276:immunology*
D000974:Antibodies, Antinuclear
Vliianie gemosorpbtsi na dinamiku immunopatologicheskkh izmeneniĭ v kozhe bol'nykh s zabolevaniiami, soprovozhdaiushchimisia sindromom immunnykh kompleksov.