A light and electron microscopical study of B-50 (GAP-43) in human intramuscular nerve and neuromuscular junctions during development.
The growth associated protein B-50 (GAP-43) is demonstrated in human intramuscular nerves and neuromuscular junctions by light microscopy and electron microscopy. Nearly all fetal endplates are shown to be immunoreactive for B-50. The percentage of B-50 positive endplates decreases significantly during the peri- and neonatal period, but in children and adults a low percentage of B-50 positive endplates remains present. These data indicate that also in the human peripheral nervous system the expression of B-50 is developmentally regulated.
Hesselmans
L F
LF
Laboratory for neuromuscular diseases, University Hospital, Utrecht, The Netherlands.
Jennekens
F G
FG
van den Oord
C J
CJ
Oestreicher
A B
AB
Veldman
H
H
Gispen
W H
WH
D000328:Adult; D000375:Aging / Q000378:metabolism*; D000911:Antibodies, Monoclonal; D002648:Child; D005333:Fetus / Q000378:metabolism*; D019922:GAP-43 Protein; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D008854:Microscopy, Electron; D024510:Muscle Development; D009132:Muscles / Q000294:innervation* / Q000648:ultrastructure; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009469:Neuromuscular Junction / Q000378:metabolism* / Q000502:physiology / Q000648:ultrastructure
D000911:Antibodies, Monoclonal; D019922:GAP-43 Protein; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins