Severe epinephrine-propranolol interaction.
A 53-year-old man presented to the emergency department with posterior pharyngeal edema. He had taken a long-acting propranolol product the previous evening that had been prescribed for migraine headaches. After administration of epinephrine subcutaneously in the ED, he developed a severe adverse reaction, characterized by profound hypertension and bradycardia. This potentially serious drug interaction is described, and relevant literature is reviewed.
Gandy
W
W
Irving Healthcare System, Texas.
D001919:Bradycardia / Q000139:chemically induced; D004347:Drug Interactions; D004487:Edema / Q000188:drug therapy*; D004837:Epinephrine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D010608:Pharyngeal Diseases / Q000188:drug therapy*; D011433:Propranolol / Q000009:adverse effects*
D011433:Propranolol; D004837:Epinephrine