[Animal models of tardive dyskinesia].
It is possible to induce in monkeys abnormal movements of the mouth and tongue resembling strikingly tardive dyskinesia. Such movements can be induced by chronic treatment with neuroleptics or by lesions placed in the habenular interpeduncular tract or nucleus parafascicularis thalami. Dopaminergic D1 and D2 receptors are involved in the modulation of such movements.
Bédard
P J
PJ
Département d'Anatomie, Faculté de Médecine, Université Laval, Québec, Canada.
Boucher
R
R
DiPaolo
T
T
D000818:Animals; D014150:Antipsychotic Agents / Q000633:toxicity; D004195:Disease Models, Animal; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D006801:Humans; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008875:Middle Aged; D051381:Rats; D013787:Thalamic Nuclei / Q000502:physiology
D014150:Antipsychotic Agents
Les modèles animaux de la dyskinésie tardive.