Accumulation dynamics of the agent of amyotrophic leukospongiosis and the development of degenerative changes in the central nervous system of guinea pigs.
After retrobulbar inoculation into guinea pigs, the agent of amyotrophic leukospongiosis was detected in the central nervous system (CNS) as early as 7 days post-infection (p.i.), whereas specific morphological changes appeared since days 14 to 21 p.i. Virological and morphological findings suggested that motoneurons of the spinal cord were first damaged in the course of the pathologic process which then proceeded upwards.
Kolomiets
N D
ND
Byelorussian Research Institute of Epidemiology and Microbiology, Ministry of Health of the Byelorussian Soviet Socialist Republic, Minsk.
Votyakov
V I
VI
Poleshchuk
N N
NN
Duboiskaya
G P
GP
Guzov
S A
SA
D000818:Animals; D002490:Central Nervous System / Q000473:pathology*; D006168:Guinea Pigs; D006801:Humans; D009046:Motor Neurons / Q000473:pathology; D009410:Nerve Degeneration; D012897:Slow Virus Diseases / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology; D013997:Time Factors