title: Is limb-sparing surgery applicable to neurogenic sarcomas of the extremities?
abstract: The presentation, treatment, and outcome of 12 patients with high-grade neurogenic sarcoma (NS) of the extremity were compared with those of 21 patients with high-grade extremity soft-tissue sarcoma of nonneural origin in a retrospective study from January 1976 to January 1988. Pain and neurologic deficit were more common in the NS group. Limb-sparing surgery was carried out with equal frequency in both groups. Local recurrence was six times more frequent in the NS group at three-year follow-up (59% vs 10%). Width of resection margin was the dominant prognostic variable bearing on local control after limb-sparing surgery. Anatomic and functional constraints tended to limit resection margin in patients with NS arising from mixed motor-sensory or predominantly motor nerves.
authors.affiliation: Department of Surgery, Ochsner Clinic, New Orleans, LA 70121.
authors.forename: J S
authors.initials: JS
authors.lastname: Bolton
authors.forename: J N
authors.initials: JN
authors.lastname: Vauthey
authors.forename: G H
authors.initials: GH
authors.lastname: Farr
authors.forename: E I
authors.initials: EI
authors.lastname: Sauter
authors.forename: J C
authors.initials: JC
authors.lastname: Bowen
authors.forename: D G
authors.initials: DG
authors.lastname: Kline
mesh_terms: D000328:Adult; D000368:Aged; D000671:Amputation, Surgical; D005121:Extremities / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D009455:Neurofibroma / Q000401:mortality / Q000601:surgery*; D012189:Retrospective Studies; D012509:Sarcoma / Q000401:mortality / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000601:surgery