title: Interaction of HIV infection with nervous tissue may play a crucial role in the development of AIDS.
abstract: In this note, we first review some of the immunopathogenic mechanisms of HIV infection and discuss the possible role of the idiotypic network in producing immunodeficiency; we then propose that the interaction of HIV with the nervous system is such as to generate signals which are misinterpreted by the nervous system: the feedback reaction of the nervous system may play a crucial role in the development of AIDS. We conclude by studying a very simple model for the dynamics of AIDS.
authors.affiliation: Dipartimento di Fisica, Università di Roma Tor Vergata.
authors.forename: G
authors.initials: G
authors.lastname: Parisi
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000503:physiopathology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000382:microbiology; D003588:Cytopathogenic Effect, Viral; D006678:HIV / Q000472:pathogenicity; D006801:Humans; D007130:Immunoglobulin Idiotypes; D009420:Nervous System / Q000503:physiopathology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D007130:Immunoglobulin Idiotypes