[Transient bone marrow inhibition caused by aminoglutethimide].
A 53-year-old woman with reversible bone marrow insufficiency caused by aminoglutethimide (AGT) treatment of metastatic breast carcinoma is described. The clinical picture included moderate thrombocytopenia and severe granulocytopenia complicated by Gram-positive septicaemia and skin infections, and by oral candidiasis. Withdrawal of AGT and antibiotic therapy resulted in clinical and haematological recovery, but the patient died suddenly, probably from a cardiac cause. Autopsy revealed widespread bone metastases, but no bone marrow infiltration of breast carcinoma. The haematological hazards caused by application of AGT are discussed.
Tel
W
W
van Lijf
J H
JH
ten Napel
C H
CH
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000616:Aminoglutethimide / Q000009:adverse effects*; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis
D000616:Aminoglutethimide
Voorbijgaande beenmergremming door aminoglutethimide.