A noradrenergic component of quinolinic acid-induced seizures.
Unilateral application of the convulsant brain metabolite, quinolinic acid, to unanesthetized rats resulted in a transient dramatic decrease in norepinephrine levels (nadir -70% after 2 h) in both the injected and the contralateral hippocampus. Dose-response relationships and the temporal sequence of this effect indicated a close functional association between seizure events and the decrease in hippocampal norepinephrine content. Massive release of the inhibitory transmitter, norepinephrine, may thus constitute the brain's defensive response to quinolinic acid-induced seizures.
Vezzani
A
A
Schwarcz
R
R
D000818:Animals; D001921:Brain / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D011725:Pyridines / Q000378:metabolism; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
D011725:Pyridines; D011805:Quinolinic Acids; D017378:Quinolinic Acid; D009638:Norepinephrine