Chronic cadmium intake results in dose-related excretion of metallothionein in urine.
Urinary excretion of metallothionein was measured by radioimmunoassay in rats given drinking water containing 5 or 50 mg cadmium/l for up to 2 years. The metallothionein levels corresponded to the concentration of cadmium in the drinking water and increased linearly over the course of the study. These results demonstrate that urinary metallothionein is a sensitive biological indicator of oral cadmium exposure.
Shaikh
Z A
ZA
Department of Pharmacology and Toxicology, University of Rhode Island, Kingston 02881.
Harnett
K M
KM
Perlin
S A
SA
Huang
P C
PC
D000818:Animals; D002104:Cadmium / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004326:Drinking; D008297:Male; D008668:Metallothionein / Q000652:urine*; D051381:Rats; D011919:Rats, Inbred Strains
D002104:Cadmium; D008668:Metallothionein