Indium-111 oxine platelet survival in dogs: effect of doxorubicin and Dacron grafts.
The cytotoxic chemotherapeutic agent doxorubicin was found to acutely decrease platelet survival times in beagle dogs as determined using platelets labeled with [111In]oxine. Recovery was rapid, with platelet survival times returning to normal within 3 wk of cessation of treatment. Doxorubicin (1.5 mg/kg i.v. every 3 wk for a total of four doses) also delayed the return of platelet survival times to normal when given to beagle dogs following placement of thoracoabdominal aortic Dacron grafts. It is not known whether or not this may have clinical significance.
Rauls
D O
DO
Moreno
A J
AJ
Gregory
G
G
Penney
L L
LL
Parker
G
G
Collins
J
J
Daniels
J R
JR
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D002470:Cell Survival; D001026:Coronary Artery Bypass; D004285:Dogs; D004317:Doxorubicin / Q000494:pharmacology*; D005260:Female; D006912:Hydroxyquinolines; D007204:Indium; D008297:Male; D015125:Oxyquinoline; D011093:Polyethylene Terephthalates; D011868:Radioisotopes
D006912:Hydroxyquinolines; D011093:Polyethylene Terephthalates; D011868:Radioisotopes; D007204:Indium; D015125:Oxyquinoline; D004317:Doxorubicin