Radiosensitizing activity of 1-alkyl-3-nitropyrrolo-(2,3-b)-pyridine derivative.
Radiosensitization characteristics of a newly synthesized N-(3,N'-morpholinpropyl)-2-[3-nitropyrrolo-(2,3-b)-pyridine -1-yl] ethanoic acid amide and the chemical basis of the action were studied. Partition coefficient, radox potentials for the one electron reduction of the compound were determined. This was confirmed by studies on the radiosensitization effect and cytotoxicity of the compound tested in vitro using Chinese hamster V79 cells. The results show that the sensitizing efficiency for this compound is C1.6 at a concentration of 0.5 mmol dm-3, which is similar to MISO. Its toxicity was not lower than that of MISO or metronidazole.
Jin
Y Z
YZ
Shanghai Institute of Radiation Medicine, Shanghai Medical University, China.
Stratford
I J
IJ
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D066298:In Vitro Techniques; D009025:Morpholines / Q000494:pharmacology* / Q000633:toxicity; D011725:Pyridines / Q000494:pharmacology* / Q000633:toxicity; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology* / Q000633:toxicity
D009025:Morpholines; D011725:Pyridines; D011838:Radiation-Sensitizing Agents; C058775:N-(3,N'-morpholinopropyl)-2-(3-nitropyrrolo-(2,3-b)pyridine-1-yl)ethanoic acid amide