Cytokine production and utilization by the motheaten mouse.
Splenocytes from the motheaten mouse, after stimulation with alloantigen, lack the ability to utilize exogenous interleukin 1 (IL 1) or interleukin 2 (IL 2), express receptors for IL 2, or produce (IL 2). However, in contrast to other models of autoimmunity and immunodeficiency, after mitogen stimulation, motheaten splenocytes produced as much IL 1 or IL 2 as their normal littermates. In addition, these splenocytes expressed functional IL 2 receptors in the same quantity as normal littermate or wild-type splenocytes. Furthermore, motheaten thymocytes and splenocytes, like their normal littermates, respond synergistically to IL 1 on co-stimulation with mitogen, suggesting expression of an IL 1 receptor. Thus, motheaten mouse splenocytes are unable to utilize an antigen-delivered signal and convert it into cytokine production or IL 2 receptor expression. If the antigen signal is bypassed with mitogen, cytokine production and receptor expression appear normal.
Stanton
T H
TH
Tubbs
C
C
Clagett
J
J
D000818:Animals; D000835:Animals, Wild; D001688:Biological Products / Q000096:biosynthesis* / Q000378:metabolism; D016207:Cytokines; D007375:Interleukin-1 / Q000096:biosynthesis / Q000378:metabolism; D007376:Interleukin-2 / Q000096:biosynthesis / Q000378:metabolism; D007519:Isoantigens / Q000276:immunology; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008222:Lymphokines / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H / Q000276:immunology*; D008810:Mice, Inbred C57BL / Q000276:immunology*; D008817:Mice, Mutant Strains / Q000276:immunology*; D013154:Spleen / Q000166:cytology
D001688:Biological Products; D016207:Cytokines; D007375:Interleukin-1; D007376:Interleukin-2; D007519:Isoantigens; D008222:Lymphokines