[The action of inhibitors of the amine nitrosation reaction in human gastric juice and in the body of animals].
The effect of ascorbic, ferulic and caffeic acids on dimethylamine and amidopyrine nitrosation in a medium containing 3 samples of total gastric juice taken from 10 humans (pH = 6.1; 3.2 and 1.7) was studied versus the amount of inhibitor added to the medium. The resultant relationship proved bizarre, the inhibitor at low concentrations stimulating nitrosation in some situations. When gastric juice concentration in the medium was further lowered by dilution with a buffer at relevant value of pH, the paradoxical effect of inhibition gradually disappeared.
Ermilov
V B
VB
Shendrikova
I A
IA
Dikun
P P
PP
D000632:Aminopyrine / Q000032:analysis / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D002109:Caffeic Acids / Q000494:pharmacology; D002849:Chromatography, Gas; D003373:Coumaric Acids / Q000494:pharmacology; D004123:Dimethylamines / Q000032:analysis / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D005750:Gastric Juice / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D051379:Mice; D008815:Mice, Inbred Strains; D009602:Nitrosamines / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000493:pharmacokinetics; D012977:Sodium Nitrite / Q000032:analysis / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics
D002109:Caffeic Acids; D003373:Coumaric Acids; D004123:Dimethylamines; D009602:Nitrosamines; D000632:Aminopyrine; C004999:ferulic acid; D012977:Sodium Nitrite; D001205:Ascorbic Acid; C040048:caffeic acid
Deĭstvie ingibitorov reaktsii nirtrozirovaniia aminov v zheludochnom soke cheloveka i v organizme zhivotnykh.