Radiosensitization of human colorectal tumor cells by 4-nitro-5-sulfonatoimidazoles.
Misonidazole, a clinically-effective 2-nitroimidazole hypoxic cell radiation sensitizer, and 12 4-nitro-5-sulfonatoimidazoles were tested in cultured human SW1116 colorectal adenocarcinoma cells for radiosensitizing efficiency. Octanol-water partition coefficients and HPLC capacity factors were determined for all agents as measurements of lipophilicity, and an excellent correlation was found between the two measurements. Cytotoxicity, in vitro glutathione reactivity, and one-electron reduction potential were also determined for each compound to evaluate potential utility as macromolecularly transported radiosensitizers. Ten members of the set were found to be 40 to 300 times more radiotoxic than misonidazole, but no correlation was found between their radiosensitizing efficiencies and the chemical and physical parameters.
Fitzpatrick
D A
DA
Center for Health Sciences, Lehigh University, Bethlehem, Pennsylvania 18015.
Heindel
N D
ND
Egolf
R A
RA
Walton
H
H
D000230:Adenocarcinoma / Q000473:pathology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D015179:Colorectal Neoplasms / Q000473:pathology*; D006801:Humans; D066298:In Vitro Techniques; D008920:Misonidazole / Q000494:pharmacology; D009593:Nitroimidazoles / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000528:radiation effects
D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; D008920:Misonidazole