title: Analysis of the DS86 atomic bomb radiation dosimetry methods using data on severe epilation.
abstract: This report presents a reanalysis of the Hiroshima and Nagasaki data on severe epilation as an acute radiation effect using both the new DS86 and the old T65D dosimetries. The focus of the report is on several aspects of the data which have previously been examined by Jablon et al (ABCC TR 12-70, 1970) and Gilbert and Ohara [Radiat. Res. 100, 124-138 (1984)]. The report examines the uniformity of epilation response across shielding category, across sex and age, and in terms of interactions between city, sex, age, and shielding category; it also investigates the apparent relative biological effectiveness (RBE) of neutrons in the DS86 dose compared with the T65D dose, using both within- and between-city information. In addition the report discusses evidence for nonlinearity in epilation response. The epilation response function exhibits nonlinearity in terms of both a marked increase in slope at about 0.75 Gy, and then, beginning at about 2.5 Gy, a leveling off and eventual decrease in response. The principal conclusions of the report are as follows. The use of the DS86 dosimetry rather than T65D increases the apparent RBE of neutrons compared with gamma dose from approximately 5 to 10. At these values of RBE the slope of the dose response, in a middle range from 0.75-2.5 Gy, is about 165% greater using DS86 than T65D. With respect to the interactions of sex, city, and shielding method, the size and significance of virtually all nonuniformities in epilation response seem using T65D are also evident with DS86. Additionally it seems difficult to find any evidence that DS86 is an improved predictor of epilation response over T65D. Finally, the fact that the nonlinearity in dose response and apparent actual downturn in epilation occurrence rate at the high end of dose is more striking with DS86 than with T65D is found to be due primarily to the common practice of truncating all T65D doses to 600 rad.
authors.affiliation: Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan.
authors.forename: D O
authors.initials: DO
authors.lastname: Stram
authors.forename: S
authors.initials: S
authors.lastname: Mizuno
mesh_terms: D000328:Adult; D000505:Alopecia / Q000209:etiology*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009502:Neutrons; D009689:Nuclear Warfare; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000209:etiology*; D011835:Radiation Protection; D011874:Radiometry / Q000379:methods*; D012062:Relative Biological Effectiveness