title: Efficacy of intrauterine infusion of plasma for treatment of infertility and endometritis in mares.
abstract: We evaluated the efficacy of intrauterine plasma infusion in mares as a treatment for infertility caused by endometritis and distinguished the effects of intrauterine infusion of plasma vs saline solution. Forty-three subfertile mares were randomly assigned to 1 of 3 treatment groups: untreated controls (n = 14), those treated by saline infusion (n = 14), and those treated by plasma infusion (n = 15). Reproductive status was assessed daily by transrectal ultrasonography. Uterine aspirates and biopsy specimens were obtained 8 days after ovulation for cytologic and histologic evaluation, and mares were treated on days 12 to 16. Uterine aspirates and biopsy specimens were obtained again on day 8 of the next estrous cycle, and the mares were bred at the subsequent estrus. A postovulation intrauterine infusion of either plasma or saline solution was administered to mares in their respective treatment groups. Biopsy specimens were scored from 1 (no indications of inflammation) to 6 (severe inflammation). The pregnancy rate was lower (P less than 0.005) for mares with scores 5 and 6 (0/5) than for those with scores 1 to 4 (17/35). There was no significant effect of treatment nor a treatment by biopsy score interaction on pregnancy rate; however, the pregnancy rate for mares treated with plasma or saline solution (9/27) tended to be lower than for the control (untreated) mares (8/13). There was no change in mean biopsy score between specimens obtained before treatment and those obtained after treatment for the control group and the group treated with saline solution; however, there was a significant increase (P less than 0.05) in scores in the group treated with plasma.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Veterinary Science, College of Agriculture and Life Sciences, University of Wisconsin, Madison 53706.
authors.forename: G P
authors.initials: GP
authors.lastname: Adams
authors.forename: O J
authors.initials: OJ
authors.lastname: Ginther
mesh_terms: D000818:Animals; D001706:Biopsy / Q000662:veterinary; D004716:Endometritis / Q000628:therapy / Q000662:veterinary*; D005260:Female; D005298:Fertility; D006734:Horse Diseases / Q000628:therapy*; D006736:Horses; D007247:Infertility, Female / Q000628:therapy / Q000662:veterinary*; D010949:Plasma; D011247:Pregnancy; D012965:Sodium Chloride / Q000627:therapeutic use; D014599:Uterus / Q000473:pathology
chemical_list: D012965:Sodium Chloride