N6-bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor.
Trivedi
B K
BK
Department of Chemistry, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.
Bridges
A J
AJ
Patt
W C
WC
Priebe
S R
SR
Bruns
R F
RF
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000378:metabolism; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D051381:Rats; D011983:Receptors, Purinergic / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D011983:Receptors, Purinergic; D000241:Adenosine