[Effect of cyclophosphane on the suppressor activity of spleen cells in mice with transplantable tumors].
The suppressor activity of the splenic cells in the cyclophosphamide (CP)-treated BALB/c mice with transplanted tumours was studied. CP was injected according to three different therapeutic effective schedules. The analysis of non-specific and antigen-specific tumour-associated suppressor activity in the splenic cell adoptive transfer system demonstrated that CP immunomodulating influence depends on the injection schedule. Usage of the most therapeutically effective CP injection schedule ensured a relative safety of the nonspecific tumour-associated suppressor activity and depression of the specific one.
Kovbasiuk
S A
SA
Iudin
V M
VM
Kushko
L Ia
LIa
Semenova-Kobzar'
R A
RA
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D007113:Immunity, Innate / Q000187:drug effects; D007116:Immunization, Passive; D008748:Methylcholanthrene; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D013154:Spleen / Q000187:drug effects* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology; D013997:Time Factors; D014185:Transplantation, Isogeneic
D003208:Concanavalin A; D008748:Methylcholanthrene; D003520:Cyclophosphamide
Vliianie tsiklofosfana na supressornuiu aktivnost' kletok selezenki mysheĭ s perevivnymi opukholiami.