title: Pituitary enlargement, hypertrichosis and blunted growth hormone secretion in primary hypothyroidism.
abstract: Pituitary hyperplasia, hypertrichosis and blunted growth hormone (GH) secretion were observed in three children with untreated primary hypothyroidism. These abnormalities disappeared and improved after thyroid hormone therapy. The recognition of these associations may eliminate unnecessary surgery and GH therapy and lead to the choice of thyroid hormone replacement therapy.
authors.affiliation: Department of Paediatrics, Hiroshima Red Cross Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nishi
authors.forename: K
authors.initials: K
authors.lastname: Hamamoto
authors.forename: M
authors.initials: M
authors.lastname: Kajiyama
authors.forename: A
authors.initials: A
authors.lastname: Fujita
authors.forename: I
authors.initials: I
authors.lastname: Kawamura
authors.forename: Y
authors.initials: Y
authors.lastname: Kagawa
authors.forename: T
authors.initials: T
authors.lastname: Kajima
authors.forename: M
authors.initials: M
authors.lastname: Yamanaka
authors.forename: T
authors.initials: T
authors.lastname: Uozumi
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D006965:Hyperplasia; D006983:Hypertrichosis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D010902:Pituitary Gland / Q000473:pathology*; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013006:Growth Hormone; D013974:Thyroxine