Enhancement of hepatic tumors induced by N-nitrosodimethylamine in female toads Bufo regularis by oestrone.
The effect of oestrone on hepatic tumours induced in the female toads Bufo regularis by N-nitrosodimethylamine (DMNA) was evaluated. Injecting the toads with DMNA induced hepatocellular carcinomas in 17% comparable with 23% in toads injected with DMNA plus oestrone. These results show that oestrone insignificantly enhanced the tumour formation. Oestrone alone induced hepatic tumours in only 4 cases and was considered as a weak initiator.
Sakr
S A
SA
Department of Zoology, Faculty of Science, Menoufia University, Egypt.
el-Mofty
M M
MM
Mohamed
A M
AM
D000818:Animals; D002025:Bufonidae; D002273:Carcinogens; D004128:Dimethylnitrosamine; D004357:Drug Synergism; D004970:Estrone; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*
D002273:Carcinogens; D004970:Estrone; D004128:Dimethylnitrosamine