Side effects of self-administration of intracavernous papaverine and phentolamine for the treatment of impotence.
Beginning October 1985, 111 men agreed to enter a prospective study of the side effects of low dose papaverine/phentolamine therapy. A total of 46 men dropped out, 30 during the initial phase. The percentage of men with painless nodules almost consistently doubled from one followup examination to the next: 8 per cent at 1 month, 17 per cent at 3 months, 32 per cent at 6 months and 57 per cent at 12 months. The average injection frequency of those with nodules was 2 1/2 times higher than those without nodules. Of the men 41 per cent required an increased dose of medications during followup, and 40 per cent of 50 men had at least 1 abnormality of liver function, most of these involving mild to moderate elevations of alkaline phosphatase and lactic dehydrogenase. Priapism was not encountered during self-injection but it did occur twice in 329 physician-administered injections. Careful regular monitoring of patients should continue as some patients enter the second year of treatment.
Levine
S B
SB
Department of Psychiatry, University Hospitals of Cleveland, Ohio.
Althof
S E
SE
Turner
L A
LA
Risen
C B
CB
Bodner
D R
DR
Kursh
E D
ED
Resnick
M I
MI
D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D007267:Injections / Q000009:adverse effects; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000008:administration & dosage / Q000009:adverse effects*; D010410:Penile Erection / Q000187:drug effects; D010411:Penile Induration / Q000139:chemically induced*; D010646:Phentolamine / Q000008:administration & dosage / Q000009:adverse effects*; D011317:Priapism / Q000139:chemically induced; D011446:Prospective Studies; D012646:Self Administration
D010208:Papaverine; D010646:Phentolamine