Interaction of HIV infection with nervous tissue may play a crucial role in the development of AIDS.
In this note, we first review some of the immunopathogenic mechanisms of HIV infection and discuss the possible role of the idiotypic network in producing immunodeficiency; we then propose that the interaction of HIV with the nervous system is such as to generate signals which are misinterpreted by the nervous system: the feedback reaction of the nervous system may play a crucial role in the development of AIDS. We conclude by studying a very simple model for the dynamics of AIDS.
Parisi
G
G
Dipartimento di Fisica, Università di Roma Tor Vergata.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000503:physiopathology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000382:microbiology; D003588:Cytopathogenic Effect, Viral; D006678:HIV / Q000472:pathogenicity; D006801:Humans; D007130:Immunoglobulin Idiotypes; D009420:Nervous System / Q000503:physiopathology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D007130:Immunoglobulin Idiotypes