Candida albicans and Candida stellatoidea, in contrast to other Candida species, bind iC3b and C3d but not C3b.
It was demonstrated that complement-coated sheep erythrocytes bind to Candida albicans cells grown in serum-free RPMI 1640 medium. Testing of purified complement components proved that iC3b and C3d were responsible for the reaction, whereas C3b and C3b-H reacted only slightly if at all. Binding occurred only to C. albicans and C. stellatoidea, not to other species pathogenic to humans. There was evidence of a lectinlike nature of the effect.
Heidenreich
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Dierich
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MP
D000818:Animals; D002175:Candida / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D011951:Receptors, Complement / Q000378:metabolism*; D017463:Receptors, Complement 3b; D017464:Receptors, Complement 3d; D012756:Sheep; D013045:Species Specificity; D013329:Structure-Activity Relationship
D011951:Receptors, Complement; D017463:Receptors, Complement 3b; D017464:Receptors, Complement 3d