Role of beta-adrenoreceptors in the inhibition of gastric acid secretion after duodenal acidification in dogs.
The role of the adrenergic system in the duodenal mechanisms that inhibit gastric acid secretion (GAS) after duodenal acidification (DA) was studied. In 12 mongrel dogs, with gastric and duodenal fistulas, six experiments were carried out evaluating pentagastrin-stimulated GAS and serum secretin levels: DA (HCl 2 ml/min) for 1 h (group A); DA (HCl 2 ml/min) for 1 h plus propranolol (group B); DA (HCl 2 ml/min) for 1 h plus phentolamine (group C); duodenal instillation of saline (2 ml/min) for 1 h (group D); (duodenal instillation of saline (2 ml/min) for 1 h plus propranolol (group E), and duodenal instillation of saline (2 ml/min) for 1 h plus phentolamine (group F). Significantly (p less than 0.05) high percentages of inhibition of GAS (49-70.5%) paralleled with increases of serum secretin levels (48.4-84%) were noted in group A and C experiments. However, DA did not inhibit GAS nor did it increase the levels of secretin in group B and D-F experiments. It is concluded that the inhibition of GAS after DA is controlled, at least in part, by the action of the beta-adrenoreceptors.
Lanas
A
A
Department of Gastroenterology, Clinical University Hospital, Zaragoza, Spain.
Sainz
R
R
Morandeira
J R
JR
Alcalde
J
J
Abos
D
D
Lozano
R
R
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000378:metabolism*; D005744:Gastric Acid / Q000378:metabolism*; D005750:Gastric Juice / Q000378:metabolism; D006851:Hydrochloric Acid; D006863:Hydrogen-Ion Concentration; D010418:Pentagastrin / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000502:physiology*
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D010418:Pentagastrin; D006851:Hydrochloric Acid; D010646:Phentolamine