An unusual combination of phototoxicity and Stevens-Johnson syndrome due to antimalarial therapy.
A 12-year-old boy developed a phototoxic rash with subsequent progression to Stevens-Johnson syndrome due to prophylactic ingestion of antimalarials (chloroquine and sulfadoxine-pyrimethamine; Fansidar). The patient recovered from his skin symptoms after 4 weeks during which he received systemic corticosteroids and antibiotics. This unusual combination of two different patterns of adverse cutaneous drug reactions was most probably caused by the sulfonamide component of Fansidar.
Ortel
B
B
Department of Dermatology I, University of Vienna, Austria.
Sivayathorn
A
A
Hönigsmann
H
H
D000962:Antimalarials / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002738:Chloroquine / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations / Q000008:administration & dosage / Q000009:adverse effects; D004359:Drug Therapy, Combination; D006801:Humans; D008288:Malaria / Q000517:prevention & control*; D008297:Male; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D011739:Pyrimethamine / Q000008:administration & dosage / Q000009:adverse effects*; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced*; D013413:Sulfadoxine / Q000008:administration & dosage / Q000009:adverse effects*; D013424:Sulfanilamides / Q000009:adverse effects*
D000962:Antimalarials; D004338:Drug Combinations; D013424:Sulfanilamides; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D002738:Chloroquine; D011739:Pyrimethamine