Synthesis and pharmacological effect of substituted phenyl-4-(2-chloroethyl)tetrahydro-1,4-oxazine hydrochlorides.
Substituted phenyl-4-(2-chloroethyl)tetrahydro-1,4-oxazine hydrochlorides were prepared by treating the corresponding amino alcohols with thionyl chloride. Since these compounds are considered to be monofunctional 2-haloalkylamine type agents, they were tested for possible alpha-adrenergic blocking activity using the rat anococcygeus muscle. The pharmacological action of this series of compounds is discussed.
Daoud
S S
SS
Department of Pharmacology and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, Sudan.
Osman
S A
SA
Karrar
M A
MA
D000316:Adrenergic alpha-Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D009025:Morpholines / Q000138:chemical synthesis* / Q000494:pharmacology; D009132:Muscles / Q000187:drug effects; D051381:Rats
D000316:Adrenergic alpha-Agonists; D009025:Morpholines