Detection of Duchenne muscular dystrophy carriers by dosage analysis using the DMD cDNA clone 8.
Deletion screening in 11 unrelated DMD patients has been performed using DMD cDNA clones 1-8. Of these 11 patients, 6 exhibit deletions of the cDNA clone 8. The carriership of 18 female relatives from these six DMD families has been investigated by dosage analysis. It is shown that dosage analysis is an available method to determine the carrier status of the female relatives of DMD patients showing a deletion within a DMD cDNA clone.
Mao
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YP
Institut für Humangenetik und Anthropologie der Universität, Heidelberg, Federal Republic of Germany.
Cremer
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M
D002872:Chromosome Deletion; D004247:DNA / Q000235:genetics*; D005260:Female; D006580:Genetic Carrier Screening; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D009136:Muscular Dystrophies / Q000235:genetics*; D010375:Pedigree
D004247:DNA