title: [Immunohistochemical and serologic detection of Ca-125 in patients with peritoneal tuberculosis and ascites].
abstract: We report on two young patients with massively elevated CA-125 serum level of 290 and 264 U/ml respectively, who clinically exhibited suddenly occurring ascites. The diagnosis of ovarian carcinoma or ruptured ovarian cystoma led to a laparotomy. During the operation, a disseminating granulomatous inflammation was evident, which was identified histologically and microbiologically as miliary tuberculosis with peritoneal invasion. CA-125 was immunohistochemically localised, sharply demarcated around the tuberculous granuloma. A possible explanation for this finding is the inflammatory mesothelial proliferation. A similarity in antigenic structures of membrane components of M. tuberculosis and CA-125 cannot be excluded. Serum CA-125 levels tested 6 months after the treatment of the tuberculosis showed a value within the normal range (less than 35 U/ml).
authors.affiliation: Frauenklinik mit Poliklinik der Universität Erlangen-Nürnberg.
authors.forename: G
authors.initials: G
authors.lastname: Ronay
authors.forename: W
authors.initials: W
authors.lastname: Jäger
authors.forename: A H
authors.initials: AH
authors.lastname: Tulusan
mesh_terms: D000293:Adolescent; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D001201:Ascites / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000175:diagnosis; D010537:Peritoneum / Q000473:pathology; D014395:Peritonitis, Tuberculous / Q000175:diagnosis* / Q000473:pathology
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate
vernacular_title: Immunhistochemischer und serologischer Nachweis des CA-125 bei Patientinnen mit Peritonealtuberkulose und Aszites.