title: Aging and Alzheimer's disease. Altered cortical serotonergic binding.
abstract: The binding of tritiated serotonin and tritiated spiperone to crude membrane preparations from human frontal poles was determined in both controls and subjects with Alzheimer's disease (AD). Using the dopamine-specific receptor antagonist sulpiride, spiperone binding in the cortex was shown to be essentially serotonergic. A decline in both serotonin and spiperone binding was found in normal aging, and an AD-related decrease was found for spiperone binding only. The AD-related decrement of spiperone binding occurred irrespective of patient age and duration of disease. Scatchard analysis indicates that both age- and disease-related decrements represent a decrease in receptor number.
authors.affiliation: Sanders-Brown Research Center on Aging, Department of Neurology, University of Kentucky Medical Center, Lexington 40536-0230.
authors.forename: D L
authors.initials: DL
authors.lastname: Sparks
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D005625:Frontal Lobe / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D012016:Reference Values; D012701:Serotonin / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism
chemical_list: D012701:Serotonin; D013134:Spiperone