Intestinal permeability assessed with different-sized polyethylene glycols in children undergoing small-intestinal biopsy for suspected celiac disease.
The gastrointestinal permeability was assessed by means of an oral load of a mixture of different-sized polyethylene glycols (PEG 400 and PEG 1000) in 76 children undergoing small-intestinal biopsy because of suspected celiac disease. Children with a mucosal abnormality suggestive of celiac disease had a lower urinary recovery of larger PEG molecules. They also displayed an altered permeability barrier, as evidenced by a lower ratio of recovery between large (1074 Da) and small (370 Da) PEG molecules. Gluten elimination and gluten challenge caused a significant change in PEG recoveries in children undergoing repeated PEG tests. Repeated assessments of intestinal permeability by means of different-sized PEGs after gluten withdrawal and challenge could complement or indicate suitable time for performing small-intestinal biopsy in children with gluten intolerance.
Fälth-Magnusson
K
K
Dept. of Pediatrics, University of Linköping, Sweden.
Jansson
G
G
Stenhammar
L
L
Sundqvist
T
T
Magnusson
K E
KE
D000293:Adolescent; D002446:Celiac Disease / Q000175:diagnosis* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D007421:Intestine, Small / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008970:Molecular Weight; D010539:Permeability; D011092:Polyethylene Glycols
D011092:Polyethylene Glycols; D005983:Glutens