title: Toxicity studies with quinine hydrochloride.
abstract: Three-month studies in the rat, a rat embryo-toxicity study and a specific study to investigate ototoxicity were carried out with quinine hydrochloride. The results of these studies suggest an acceptable daily intake of 40 mg quinine hydrochloride for an adult. There were no indications of teratogenic effects and no indications of interference with auditory function in rats receiving up to 200 mg/kg.
authors.affiliation: Huntingdon Research Centre, Cambs, U.K.
authors.forename: J C
authors.initials: JC
authors.lastname: Colley
authors.forename: J A
authors.initials: JA
authors.lastname: Edwards
authors.forename: R
authors.initials: R
authors.lastname: Heywood
authors.forename: D
authors.initials: D
authors.lastname: Purser
mesh_terms: D000818:Animals; D004326:Drinking / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D006309:Hearing / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011803:Quinine / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011803:Quinine