title: Operative treatment of acute hip fractures: its effect on serum creatine kinase, lactate dehydrogenase and their isoenzymes.
abstract: Serum creatine kinase, lactate dehydrogenase, and their isoenzymes were prospectively studied in 16 patients who underwent operative treatment of acute hip fractures. No perioperative myocardial infarctions occurred; however, two patients died of noncardiac causes. We found that skeletal muscle injury associated with operative treatment of acute hip fractures did not result in significant elevations of serum CK-MB or the LD-1/LD-2 ratio. CK-MB activity exceeding 5% of total CK activity was observed in five patients who did not experience acute perioperative myocardial infarction; however, no patient had an absolute CK-MB value exceeding 50 IU/L. Elevations of serum CK-MB exceeding 50 IU/L and a LD-1/LD-2 ratio exceeding 1.0, therefore, should not be attributed to skeletal muscle injury alone following the operative treatment of acute hip fractures.
authors.affiliation: Orthopaedic Surgery Service, Walter Reed Army Medical Center, Washington, D.C.
authors.forename: D K
authors.initials: DK
authors.lastname: Wukich
authors.forename: J J
authors.initials: JJ
authors.lastname: Callaghan
authors.forename: G M
authors.initials: GM
authors.lastname: Graeber
authors.forename: T
authors.initials: T
authors.lastname: Martyak
authors.forename: J J
authors.initials: JJ
authors.lastname: Lyon
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001863:Bone Screws; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006620:Hip Fractures / Q000097:blood / Q000201:enzymology / Q000601:surgery*; D006622:Hip Prosthesis; D006801:Humans; D007431:Intraoperative Complications; D007527:Isoenzymes / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis; D011446:Prospective Studies
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase