Toward a quantitative approach for the prediction of the fraction of dose absorbed using the absorption potential concept.
An equation based on the absorption potential concept was developed. This enabled us to establish an approach for the quantitative prediction of the fraction of dose absorbed. Classification of drugs into three broad categories, according to their absorption potential values in relation to the fraction of dose absorbed, was attempted. The new approach was tested using literature data with very good results.
Macheras
P E
PE
Department of Pharmacy, University of Athens, Greece.
Symillides
M Y
MY
D000042:Absorption; D001682:Biological Availability; D015233:Models, Statistical; D004364:Pharmaceutical Preparations / Q000145:classification*; D010599:Pharmacokinetics; D012044:Regression Analysis
D004364:Pharmaceutical Preparations