title: Variables of patient-controlled analgesia. 1. Bolus size.
abstract: The efficacy of a range of demand doses of morphine for patient-controlled analgesia was studied. Patients who self-administered the smallest dose (0.5 mg) were frequently unable to achieve good pain control; patients who received the largest dose (2 mg) had a high incidence of ventilatory depression. A dose of 1 mg was the best increment under the conditions of this study but the relationship between increment and lockout interval requires consideration.
authors.affiliation: Department of Anaesthesia and Intensive Care Flinders University of South Australia, Bedford Park.
authors.forename: H
authors.initials: H
authors.lastname: Owen
authors.forename: J L
authors.initials: JL
authors.lastname: Plummer
authors.forename: I
authors.initials: I
authors.lastname: Armstrong
authors.forename: L E
authors.initials: LE
authors.lastname: Mather
authors.forename: M J
authors.initials: MJ
authors.lastname: Cousins
mesh_terms: D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*; D011897:Random Allocation; D012646:Self Administration
chemical_list: D009020:Morphine