title: A preliminary comparison of lidocaine and xylazine as epidural analgesics in ponies.
abstract: Xylazine (0.35 mg/kg) or lidocaine (0.35 mg/kg) was injected into the epidural space of six ponies to compare their effectiveness as epidural analgesics. Each pony received both treatments at 1 week intervals with the order of treatments randomized. Xylazine produced analgesia of significantly longer duration (247 +/- 58 minutes) than that produced by an equal dose of lidocaine (135 +/- 22 minutes). Mild transient ataxia of no clinical significance developed in all ponies with both treatments. Spinal cords were removed from two ponies and examined histologically. No discernible pathologic changes were noted.
authors.affiliation: University of Illinois, College of Veterinary Medicine, Urbana 61801.
authors.forename: L W
authors.initials: LW
authors.lastname: Fikes
authors.forename: H C
authors.initials: HC
authors.lastname: Lin
authors.forename: J C
authors.initials: JC
authors.lastname: Thurmon
mesh_terms: D015360:Analgesia, Epidural / Q000662:veterinary*; D000818:Animals; D005260:Female; D006736:Horses / Q000502:physiology*; D008012:Lidocaine / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D013116:Spinal Cord / Q000187:drug effects; D013843:Thiazines / Q000627:therapeutic use*; D014991:Xylazine / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D013843:Thiazines; D014991:Xylazine; D008012:Lidocaine