[Cytostatic action of the peritoneal cells of Syrian hamsters to transformed and tumor cells in vitro and its suppression by prostaglandin E2].
High antitumour activity of Syrian hamster peritoneal cells (PC) is demonstrated in the cytostatic test in vitro. The cytostatic effect (CSE) of PC on hamster cell strains can be revealed at the very early stage (7 hours of cocultivation) and it remains stable during at least 24 hours. Single intraperitoneal injection of physiological (10(-9) M) or pharmacological (10(-7)) doses of prostaglandin E2 preparation leads to the prolonged and significant inhibition of CSE of PC.
Lavnikova
N A
NA
Gorbatova
E A
EA
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000276:immunology; D002472:Cell Transformation, Viral / Q000187:drug effects*; D006224:Cricetinae; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D015232:Dinoprostone / Q000494:pharmacology*; D005260:Female; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000276:immunology*; D010529:Peritoneal Cavity / Q000166:cytology* / Q000276:immunology; D013997:Time Factors; D014407:Tumor Cells, Cultured
D015232:Dinoprostone
Tsitostaticheskoe deĭstvie peritoneal'nykh kletok siriĭskikh khomiakov na transformirovannye i opukholevye kletki in vitro i ego podavlenie prostaglandinom E2.