Metabolic products of microorganisms. 252. Isolation of new nikkomycins from Streptomyces tendae.
Two new nikkomycins were isolated from the culture broth of Streptomyces tendae Tü 901/PF 53+-3. The new compounds are the dipeptide nikkomycin pseudo-Z (psi Z) and tripeptide nikkomycin pseudo-J (psi J), which are analogues to nikkomycins Z and J. Nikkomycins pseudo-Z and pseudo-J have a C-glycosidic linkage between uracil and 5-amino-5-deoxy-D-allo-furanuronic acid, which is comparable to the C-glycosidic bond in pseudouridine. The new Cc-nucleoside nikkomycins exhibit a lower biological activity than the CN-nucleoside nikkomycins.
Decker
H
H
Department of Microbiology, University of Tübingen, FRG.
Bormann
C
C
Fiedler
H P
HP
Zähner
H
H
Heitsch
H
H
König
W A
WA
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification*; D003470:Culture Media / Q000032:analysis; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism*; D015003:Yeasts / Q000187:drug effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003470:Culture Media; C059023:nikkomycin pseudo-Z; C059024:nikkomycin pseudo-J; C059022:nikkomycin J; C011952:nikkomycin