Brain neurotransmitters in glycine encephalopathy.
We measured neurotransmitter markers in autopsied brain of infants with glycine encephalopathy (GE). Because patients with GE develop intractable seizures, special attention was devoted to those neurotransmitter systems implicated in human epilepsy. Mean levels of glycine in the frontal cortex of GE patients were three times higher than control values. No abnormalities were observed for concentrations of gamma-aminobutyric acid (and related receptors), other major neurotransmitter amino compounds, or activities of cholineacetyltransferase and aspartate aminotransferase. Mean acetylcholinesterase activity was significantly elevated by 46%. As experimental data suggest, glycine markedly potentiates the action of the excitatory neurotransmitter glutamic acid. To the extent that the brain seizures in patients with GE can be explained by this mechanism, pharmacotherapy with excitatory amino acid antagonists may represent a new approach to the treatment of GE.
Kish
S J
SJ
Clarke Institute of Psychiatry, Human Brain Laboratory, Toronto, Ontario, Canada.
Dixon
L M
LM
Burnham
W M
WM
Perry
T L
TL
Becker
L
L
Cheng
J
J
Chang
L J
LJ
Rebbetoy
M
M
D000592:Amino Acid Metabolism, Inborn Errors / Q000378:metabolism*; D000596:Amino Acids / Q000032:analysis*; D001928:Brain Diseases, Metabolic / Q000378:metabolism*; D002540:Cerebral Cortex / Q000032:analysis*; D005998:Glycine / Q000378:metabolism*; D006801:Humans; D007223:Infant; D018377:Neurotransmitter Agents / Q000032:analysis*; D010743:Phospholipids / Q000032:analysis; D012016:Reference Values
D000596:Amino Acids; D018377:Neurotransmitter Agents; D010743:Phospholipids; D005998:Glycine