[Effect of the tripeptide melanostatin on the electrical activity of surviving slices of the olfactory cortex in the rat brain].
The effects of melanostatin (MST 10(-5) M) on transmission in the lateral olfactory tract--superficial pyramidal neurons synapses, were investigated in slices of the rat olfactory cortex. Within 3-6 min after MST addition, the EPSP amplitudes were depressed and then increased (within 6-9 to 30 min); spikes and IPSPs appeared during the latter period. The recovery of the FPs to control values at washing was slow (40-60 min). Possible mechanisms of the MST long-term excitatory effect on neural elements of the slices, are discussed.
Mokrushin
A A
AA
Bagaeva
T R
TR
Gerasimova
I A
IA
Emel'ianov
N A
NA
Mitiushov
M I
MI
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D009075:MSH Release-Inhibiting Hormone / Q000494:pharmacology*; D008297:Male; D008839:Microelectrodes; D009433:Neural Inhibition / Q000187:drug effects; D009833:Olfactory Pathways / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000187:drug effects; D014022:Tissue Survival / Q000187:drug effects
D009075:MSH Release-Inhibiting Hormone
Vliianie tripeptida melanostatina na élektricheskuiu aktivnost' perezhivaiushchikh srezov oboniatel'noĭ kory mozga krys.