title: Immunologic effects of nonsteroidal anti-inflammatory agents.
abstract: The author discusses the evidence that PGE is an immunomodulator and addresses the thesis that nonsteroidal anti-inflammatory agents, by blocking endogenous PGE production, act to partially correct the immunologic aberrations involved in the pathogenesis of rheumatoid arthritis.
authors.forename: J S
authors.initials: JS
authors.lastname: Goodwin
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology; D015232:Dinoprostone; D005246:Feedback; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects; D011448:Prostaglandin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D011458:Prostaglandins E / Q000096:biosynthesis / Q000494:pharmacology; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism
chemical_list: D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; D015232:Dinoprostone