title: The expression of schizophrenia, affective disorder and vulnerability to tardive dyskinesia in an extensive pedigree.
abstract: The demography, psychiatric morbidity, and motor consequences of long-term neuroleptic treatment in the 14 children born to a father with a family history of chronic psychiatric illness and a mother with a late-onset affective disorder resulting in suicide are documented. Twelve siblings lived to adulthood, nine of whom were admitted to a psychiatric hospital in their second or third decade, and required continuous in-patient care; five remaining in hospital, with long-term exposure to neuroleptics, had chronic, deteriorating, schizophrenic illness and emergence of movement disorder. Two siblings showed no evidence of psychosis but developed a late-onset affective disorder. The implications for the issues of homotypia, vulnerability to involuntary movements, and interaction with affective disorder are discussed.
authors.affiliation: Royal College of Surgeons, St Stephen's Green, Dublin, Ireland.
authors.forename: J L
authors.initials: JL
authors.lastname: Waddington
authors.forename: H A
authors.initials: HA
authors.lastname: Youssef
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects; D002908:Chronic Disease; D004409:Dyskinesia, Drug-Induced / Q000209:etiology / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000235:genetics*; D010375:Pedigree; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D014150:Antipsychotic Agents