title: Electrochemical characteristics of nitro-heterocyclic compounds of biological interest. II. Nitrosochloramphenicol.
abstract: The electrochemical characteristics of nitrosochloramphenicol have been studied in aqueous buffer systems (pH 7.1) using direct current (d.c.) and differential pulse polarography, cyclic voltammetry and coulometric techniques. Up to 4 charge-transfer steps can be identified. The first reduction step is reversible both chemically and electrochemically, the charge-transfer product showing no tendency to undergo further reaction on the electrochemical time-scale. In contrast, the second reduction step is irreversible, with the product undergoing a fast following reaction to yield a redox-active species which was detected by cyclic voltammetry. From the data and by comparison with related systems, two reduction mechanisms are possible and are discussed.
authors.affiliation: Chemotherapy Research Unit, North East London Polytechnic.
authors.forename: J H
authors.initials: JH
authors.lastname: Tocher
authors.forename: R C
authors.initials: RC
authors.lastname: Knight
authors.forename: D I
authors.initials: DI
authors.lastname: Edwards
mesh_terms: D002701:Chloramphenicol / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D004563:Electrochemistry; D010084:Oxidation-Reduction; D011048:Polarography
chemical_list: D002701:Chloramphenicol; C026099:nitrosochloramphenicol