title: [Lymphocyte system and relative resistance of inbred mice to Trypanosoma brucei brucei].
abstract: The distribution of B-(Ig+) and T-(Thy1.2+, Lyt1+, Lyt2+) lymphocyte subsets in murine lymphoid organs was analysed by immunofluorescence (FACS) on cell suspensions throughout a primary infection of C3H/He (susceptible) and CBA/Ca (subtolerant) inbred mice with metacyclic Trypanosoma brucei brucei EATRO 1125. A direct correlation was observed between (1) the level of first-peak parasitaemia, (2) its subsequent control by the host and (3) survival time. In the course of the infection, the overall population of spleen and lymph node lymphocytes was subject to polyclonal activation whilst the proportion of differentiated B and T subsets decreased accordingly. No correlation was found between modulation of the lymphocyte system and susceptibility to trypanosomiasis.
authors.affiliation: Laboratoire de Protozoologie, Institut de Médecine tropicale, Antwerpen, Belgique.
authors.forename: A M
authors.initials: AM
authors.lastname: Makumyaviri
authors.forename: M
authors.initials: M
authors.lastname: Sileghem
authors.forename: D
authors.initials: D
authors.lastname: Le Ray
authors.forename: R
authors.initials: R
authors.lastname: Hamers
authors.forename: P
authors.initials: P
authors.lastname: de Baetselier
mesh_terms: D000818:Animals; D000950:Antigens, Ly / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology*; D007113:Immunity, Innate; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D018800:Thy-1 Antigens; D013997:Time Factors; D014346:Trypanosoma brucei brucei / Q000276:immunology; D014353:Trypanosomiasis, African / Q000276:immunology*
chemical_list: D000950:Antigens, Ly; D000954:Antigens, Surface; D011947:Receptors, Antigen, B-Cell; D018800:Thy-1 Antigens
vernacular_title: Système lymphocytaire et résistance relative de la souris consanguine à Trypanosoma brucei brucei.