title: 9,11-cyclic acetal derivatives of (9S)-9-dihydroerythromycin A.
abstract: A series of 9,11-cyclic acetal derivatives of (9S)-9-dihydroerythromycin A (4) have been prepared and their antibacterial activities compared to those of erythromycin A and 9-dihydroerythromycin A. Many of the cyclic acetal derivatives showed better antibacterial activity than their parent 4. In particular, the acetaldehyde acetal (9-O,11-O-ethylidene-9-dihydroerythromycin A) (8b) showed good antibacterial activity in comparison with erythromycin A but was not sufficiently improved in vivo to warrant progression.
authors.affiliation: Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Betchworth, Surrey, UK.
authors.forename: E
authors.initials: E
authors.lastname: Hunt
authors.forename: D J
authors.initials: DJ
authors.lastname: Knowles
authors.forename: C
authors.initials: C
authors.lastname: Shillingford
authors.forename: J M
authors.initials: JM
authors.lastname: Wilson
authors.forename: I I
authors.initials: II
authors.lastname: Zomaya
mesh_terms: D003500:Cyclization; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D004917:Erythromycin