[Effect of ionol on carcinogenesis in the kidneys].
The effect of treatment with an antioxidant--ionol (2,6-di-tert-butyl, 4-methylphenol)--on nitrosodimethylamine-induced carcinogenesis was studied. Large doses of ionol were found to inhibit tumor development in the kidney. This also involved intensification of spontaneous peroxidation of renal cortical membrane cell lipids which in turn was inhibited when additional stimulation with iron was carried out.
Kozhevnikova
E P
EP
Beliaeva
N M
NM
Matchin
G A
GA
Kirillov
V N
VN
Kopylov
Iu N
IuN
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D004128:Dimethylnitrosamine; D004353:Drug Evaluation, Preclinical; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D010743:Phospholipids; D002084:Butylated Hydroxytoluene; D008315:Malondialdehyde; D004128:Dimethylnitrosamine
Vliianie ionola na kantserogenez v pochkakh.