Mathematical model of cardiac mechanogram rhythmicity (based on mollusc heart).
1. The time course of force development by the heart is modelled by Gompertz kinetics from the product of two terms: a cumulative increase in relative number of activated "contractile units", and an exponential decrease in contractile force. 2. For each beat, an "initial condition" is specified by an "intrinsic tension" parameter, and a specific rate of change of tension; cardioactive agents change these specifications. 3. Depending on parameter values, heartbeats are predicted that are constant, or in which the frequency, amplitude and baseline tension are appropriate to inhibited or augmented cardiac activity.
Easton
D M
DM
Department of Biological Science, Florida State University, Tallahassee 32316.
D000818:Animals; D006321:Heart / Q000502:physiology*; D008433:Mathematics; D008955:Models, Cardiovascular; D008974:Mollusca / Q000502:physiology*; D009200:Myocardial Contraction