title: [Amino acid sequence of neurotoxins IV and V from the sea anemone Radianthus macrodactylus].
abstract: Amino acid sequences of neurotoxins RTX-IV and RTX-V isolated from the sea anemone Radianthus macrodactylus were determined by the automated Edman degradation; their polypeptide chains consist of 48 and 47 amino acid residues, respectively. For identification of tryptophan-30 in toxin RTX-IV, its trypsin and chymotrypsin digests were investigated. Amino acid sequences of the above toxins show that they belong to a new structural class and that C-terminal positive charge and tyrosine-25 are important for toxic activity of sea anemone polypeptides.
authors.forename: T A
authors.initials: TA
authors.lastname: Zykova
authors.forename: E P
authors.initials: EP
authors.lastname: Kozlovskaia
authors.forename: G B
authors.initials: GB
authors.lastname: Eliakov
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003063:Cnidaria; D003064:Cnidarian Venoms / Q000032:analysis*; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000032:analysis*; D012615:Sea Anemones
chemical_list: D003064:Cnidarian Venoms; D009498:Neurotoxins; C055387:toxin IV (Anemonia sulcata); C035569:toxin V (Anemonia sulcata)
vernacular_title: Aminokislotnaia posledovatel'nost' neĭrotoksinov IV i V iz aktinii Radianthus macrodactylus.