H2-receptor-mediated stress-induced analgesia is dependent on neither pituitary nor adrenal activation.
The effects of hypophysectomy and adrenalectomy were studied on the analgesia elicited by a 3 min exposure to 3.5 mA of continuous inescapable footshock, a response previously shown to be resistant to high doses of the opiate antagonist, naloxone, but inhibited by antagonists of histamine H2-receptors. Neither treatment significantly attenuated the response, and the brain-penetrating H2-receptor antagonist zolantidine inhibited the response in all surgical treatment groups. These results add further support for our hypothesis that brain histamine and brain H2-receptors mediate nonopiate analgesia.
Gogas
K R
KR
Department of Pharmacology and Toxicology, Albany Medical College, NY 12208.
Hough
L B
LB
D000315:Adrenalectomy; D000698:Analgesia; D000818:Animals; D052160:Benzothiazoles; D004597:Electroshock; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D007016:Hypophysectomy; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D050198:Phenoxypropanolamines; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D013844:Thiazoles / Q000494:pharmacology*
D052160:Benzothiazoles; D006635:Histamine H2 Antagonists; D050198:Phenoxypropanolamines; D010880:Piperidines; D011970:Receptors, Histamine H2; D013844:Thiazoles; D009270:Naloxone; C055302:zolantidine