Age-dependent beta-adrenergic response of neuronal discharge in the raphe dorsalis: evidence of a transient regulation.
Extracellular recordings from raphe dorsalis neurons in rats during development were performed, and the response to iontophoretically applied beta-antagonists was analysed. In pups younger than 2 weeks, raphe dorsalis firing was totally or partially inhibited by application of beta-antagonists, while after 2 weeks of age the neurons were insensitive to the same application. The beta-receptors appeared to be involved in the control of raphe firing during a transient period of ontogenesis and thus the disappearance of beta-regulation at older ages may reflect the regression of this population of neurotransmitter receptors.
Lanfumey
L
L
INSERM U 288, CHU Pitié Salpétrière, Paris, France.
Adrien
J
J
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D004594:Electrophysiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology; D011903:Raphe Nuclei / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*
D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D011433:Propranolol