title: The long-lasting state of specific nonresponsiveness induced by intravenous immunization with alloantigens is due to the generation of recirculating suppressor T cells.
abstract: We investigated whether the long-lasting state of nonresponsiveness that is induced by intravenous immunization with alloantigens is mediated by suppressor T cells, or is caused by inactivation or deletion of the relevant alloreactive T cell clones. The data from parabiosis and thoracic duct drainage experiments suggest that the state of nonresponsiveness depends on recirculating non-proliferating Ts memory cells.
authors.forename: A T
authors.initials: AT
authors.lastname: Bianchi
authors.forename: L M
authors.initials: LM
authors.lastname: Hussaarts-Odijk
authors.forename: H
authors.initials: H
authors.lastname: Bril
authors.forename: H
authors.initials: H
authors.lastname: de Ruiter
authors.forename: R
authors.initials: R
authors.lastname: Benner
mesh_terms: D000818:Animals; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007114:Immunization; D007156:Immunologic Memory; D007165:Immunosuppression Therapy; D007519:Isoantigens / Q000276:immunology; D017710:Lymphocyte Transfusion; D051379:Mice; D008815:Mice, Inbred Strains; D010227:Parabiosis; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013997:Time Factors; D014747:Vinblastine / Q000494:pharmacology
chemical_list: D007519:Isoantigens; D014747:Vinblastine