Aluminum removal after chronic intoxication in rats.
Aluminum concentrations were measured in serum and in the bone, liver, spleen, kidney and brain of male Wistar rats treated with aluminum lactate. The administration was performed intraperitoneally over a period of 109 days, giving a total elemental aluminum dose of 128 mg per rat. After loading, a group of animals was killed together with blanks to verify the level of aluminum accumulation. Two groups of remaining rats were administered with deferoxamine over a period of six and fifteen weeks, respectively, receiving total doses of 270 and 675 mg of DFO. The concentrations of aluminum in serum and in tissues were compared with those found in other groups of animals undergoing aluminum suspension. The determination of iron in liver was also performed. Results indicate that in this experimental model the action of deferoxamine was preferential toward tone while it seemed lacking in the other examined tissues.
Giordano
R
R
Istituto Superiore di Sanità, Rome, Italy.
Ioppolo
A
A
Ciaralli
L
L
Rubbiani
M
M
Vernillo
I
I
Costantini
S
S
D000535:Aluminum / Q000493:pharmacokinetics / Q000506:poisoning*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002908:Chronic Disease; D003676:Deferoxamine / Q000627:therapeutic use; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D000535:Aluminum; D003676:Deferoxamine