Transplantation of multiple abdominal viscera.
Two children with the short-gut syndrome and secondary liver failure were treated with evisceration and transplantation en bloc of the stomach, small intestine, colon, pancreas, and liver. The first patient died perioperatively, but the second lived for more than 6 months before dying of an Epstein-Barr virus-associated lymphoproliferative disorder that caused biliary obstruction and lethal sepsis. There was never evidence of graft rejection or of graft-vs-host disease in the long-surviving child. The constituent organs of the homograft functioned and maintained their morphological integrity throughout the 193 days of survival.
Starzl
T E
TE
Department of Surgery, School of Pharmacy, University of Pittsburgh Health Center, University of Pittsburgh, Pa.
Rowe
M I
MI
Todo
S
S
Jaffe
R
R
Tzakis
A
A
Hoffman
A L
AL
Esquivel
C
C
Porter
K A
KA
Venkataramanan
R
R
Makowka
L
L
D000818:Animals; D001344:Autopsy; D002648:Child; D002675:Child, Preschool; D003524:Cyclosporins / Q000008:administration & dosage / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007422:Intestines / Q000502:physiology; D008099:Liver / Q000503:physiopathology; D008232:Lymphoproliferative Disorders / Q000276:immunology; D010179:Pancreas / Q000201:enzymology / Q000502:physiology; D011182:Postoperative Care; D011183:Postoperative Complications; D013552:Swine; D014781:Viscera / Q000637:transplantation*
D003524:Cyclosporins