title: Adenocarcinoma of the prostate in cystoprostatectomy specimens removed for bladder cancer.
abstract: The prostate glands of 84 men undergoing cystoprostatectomy for bladder cancer were examined by whole-mount sections at 4-mm to 5-mm intervals to identify unsuspected prostate adenocarcinoma (PCa). Of 72 white patients with entirely normal digital rectal examinations (DRE), 33 (46%) were found to have PCa, including 12 (17%) who had a Gleason score of 6 or greater and seven (10%) who had penetration through the prostatic capsule. These observations are consistent with previous studies in autopsy populations but allow a more appropriate comparison with morphologic data generated from radical prostatectomy specimens. If these data can be extended to the age-matched general population, treatment at a 1% mortality rate for all white men 60 to 74 years of age with a PCa with a Gleason score of 6 or greater could cause between 6190 and 30,951 deaths, in contrast to 7335 deaths expected from the cancer. These data stress the need for a control group in a study designed to evaluate the benefit of early diagnosis and treatment of PCa.
authors.affiliation: Department of Urology, Cleveland Clinic Foundation, Ohio.
authors.forename: J E
authors.initials: JE
authors.lastname: Montie
authors.forename: D P
authors.initials: DP
authors.lastname: Wood
authors.forename: J E
authors.initials: JE
authors.lastname: Pontes
authors.forename: J M
authors.initials: JM
authors.lastname: Boyett
authors.forename: H S
authors.initials: HS
authors.lastname: Levin
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000601:surgery*