A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein.
The human lymphoid-specific transcription factor OTF-2 contains a homoeodomain that is required for DNA binding and binds specifically to DNA elements that are recognized by Drosophila homoeodomain proteins, suggesting coevolutionary relationships between mammalian and invertebrate homoeodomain proteins and their DNA recognition elements.
Scheidereit
C
C
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021.
Cromlish
J A
JA
Gerster
T
T
Kawakami
K
K
Balmaceda
C G
CG
Currie
R A
RA
Roeder
R G
RG
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins; D005786:Gene Expression Regulation; D005801:Genes, Homeobox; D005803:Genes, Immunoglobulin; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008969:Molecular Sequence Data; D050813:Octamer Transcription Factor-2; D011487:Protein Conformation; D012333:RNA, Messenger / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D050813:Octamer Transcription Factor-2; C058435:POU2F2 protein, human; D012333:RNA, Messenger; D014157:Transcription Factors