Use of ranitidine in children undergoing cardiopulmonary bypass.
Sixty children aged 6 wk to 10 yr were studied. The children were undergoing cardiopulmonary bypass (CPB) for correction of congenital heart defects. The aim of the study was to provide prophylaxis for stress-induced gastric ulceration by elevating the gastric pH to at least 3.5. Two infusion regimes of ranitidine were compared: 0.1 and 0.2 mg/kg.h. The period of study was from induction of anesthesia until the end of the first 24 h after surgery. Both regimes were effective. The 0.2-mg/kg.h infusion produced a significantly higher plasma concentration of ranitidine throughout the study period without any additional clinical benefit. Both regimes produced, within 3 h of cessation of CPB, a significant elevation in mean gastric pH to at least 5.3. This paper concludes that 0.1-mg/kg.h infusion of ranitidine is a safe and efficacious regime for the critically ill pediatric patient.
Eddleston
J M
JM
Royal Liverpool Children's Hospital, UK.
Booker
P D
PD
Green
J R
JR
D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D003422:Critical Care; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D011292:Premedication; D011897:Random Allocation; D011899:Ranitidine / Q000008:administration & dosage* / Q000097:blood; D013276:Stomach Ulcer / Q000517:prevention & control*; D013312:Stress, Physiological
D011899:Ranitidine