Modality-specific antinociception produced by intrathecal injection of anti-somatostatin antiserum in rats.
An intrathecal injection of antiserum against somatostatin significantly inhibited the nociceptive response to thermal but not mechanical stimulation in non-arthritic and adjuvant arthritic rats. The thermal antinociception induced by intrathecally injected anti-somatostatin antiserum was more remarkable in adjuvant arthritic rats than in non-arthritic ones. These results suggest that endogenous somatostatin participates in transmission of thermal nociception in the rat spinal dorsal horn in non-arthritic and arthritic conditions.
Ohno
H
H
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Kuraishi
Y
Y
Minami
M
M
Satoh
M
M
D000818:Animals; D006358:Hot Temperature; D007106:Immune Sera / Q000494:pharmacology*; D007278:Injections, Spinal; D008297:Male; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000378:metabolism*; D010812:Physical Stimulation; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000276:immunology / Q000502:physiology*
D007106:Immune Sera; D013004:Somatostatin