title: Action of a chronic arecoline administration on mouse motility and on acetylcholine concentrations in the CNS.
abstract: The modifications of mouse motility and of the levels of acetylcholine (ACh) in two sections of the CNS caused by a chronic administration of 4.5; 9.5; 28.5 and 60 mg kg-1 day-1 of arecoline for 20 days have been studied. At low doses (4.5 and 9.5 mg kg-1 day-1), arecoline caused no modification of the ACh levels and of the motility. The higher doses (28.5 and 60 mg kg-1 day-1) caused a reduction of the mouse motility and an increase of the ACh levels in the subcortical structures of the CNS of the mouse.
authors.affiliation: Institute of Pharmacology and Pharmacognosy, University of Turin, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Molinengo
authors.forename: A M
authors.initials: AM
authors.lastname: Fundaró
authors.forename: M C
authors.initials: MC
authors.lastname: Cassone
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*
chemical_list: D001115:Arecoline; D000109:Acetylcholine