title: The adrenergic innervation of pulmonary vasculature in the normal and pulmonary hypertensive rat.
abstract: It would appear that susceptibility to chronic proliferative pulmonary hypertension in response to chronic alveolar hypoxia is most severe in species in which adrenergic innervation of pulmonary arteries is reduced or lacking. Intrapulmonary arteries of the rat have been reported to lack adrenergic innervation by some workers but not others. Since the rat develops severe proliferative pulmonary hypertension in response to prolonged alveolar hypoxia, the different divisions of the lung vasculature of Sprague-Dawley rats were thoroughly examined to determine the presence or absence of an adrenergic innervation. The degree of innervation in normal rats was compared with that of rats developing pulmonary hypertension. Both in normal and experimental pulmonary hypertensive rats the pulmonary arteries, all their branches and the small pulmonary veins with a smooth muscle media were found to be devoid of adrenergic innervation. In contrast, the cardiac-like muscle in the media of large pulmonary veins, the bronchial arteries and the vasa vasorum of larger vessels were richly innervated by adrenergic nerves. Thus the increase in medial smooth muscle which occurs in pulmonary arteries during chronic alveolar hypoxia is independent of a pre-existing adrenergic innervation or of such an innervation newly derived from that of adjacent vessels or structures. This is in contrast to systemic vessels where it has been suggested that increased adrenergic activity and density of innervation may augment hypertrophy of the media in hypertensive animals. Adrenergic nerves are suggested to have a protective action on pulmonary vessels.
authors.forename: J R
authors.initials: JR
authors.lastname: McLean
authors.forename: B M
authors.initials: BM
authors.lastname: Twarog
authors.forename: E H
authors.initials: EH
authors.lastname: Bergofsky
mesh_terms: D000320:Adrenergic Fibers / Q000503:physiopathology*; D000818:Animals; D006332:Cardiomegaly / Q000503:physiopathology; D002395:Catecholamines / Q000032:analysis; D006651:Histocytochemistry; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology; D008168:Lung / Q000098:blood supply* / Q000294:innervation / Q000473:pathology; D008297:Male; D008407:Mast Cells / Q000473:pathology; D011651:Pulmonary Artery / Q000294:innervation; D011654:Pulmonary Edema / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D002395:Catecholamines