Pseudocholinesterase activity in human cerebrospinal fluid.
Pseudocholinesterase (PCHE) activity and dibucaine numbers (DN) in the cerebrospinal fluid (CSF) and plasma of 10 ASA physical status 1 and 2 patients were measured using a kinetic method. CSF had a mean PCHE activity of 0.018 +/- 0.013 unit/ml with a DN of 59 +/- 4. Whereas, PCHE activity and DN in the plasma were 0.960 +/- 0.12 units/ml and 84 +/- 3, respectively. We also measured PCHE activity and DN in the CSF and plasma of 4 patients in whom there was a recent history of intraventricular bleeding. These patients had a CSF PCHE activity of 0.340 +/- 0.07 units/ml (DN = 78 +/- 3) and a plasma PCHE activity of 0.950 +/- 0.10 units/ml (DN = 82 +/- 2). Our data show that there is a low activity of PCHE in CSF, 1/20-1/100th that of plasma. Our data also show that PCHE activity increased to 1/4 to 1/2 that of plasma in CSF of patients with bleeding into CSF.
Kambam
J R
JR
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232.
Horton
B
B
Parris
W C
WC
Hyman
S A
SA
Berman
M L
ML
Sastry
B V
BV
D000328:Adult; D000368:Aged; D002091:Butyrylcholinesterase / Q000134:cerebrospinal fluid*; D002802:Cholinesterases / Q000134:cerebrospinal fluid*; D003992:Dibucaine / Q000134:cerebrospinal fluid; D006801:Humans; D006868:Hydrolysis; D008875:Middle Aged; D011343:Procaine / Q000378:metabolism
D011343:Procaine; D002091:Butyrylcholinesterase; D002802:Cholinesterases; D003992:Dibucaine