The local modulation of vascular permeability by endothelial cell derived products.
Endothelin has been shown to suppress increased vascular permeability in the rat at doses of 0.01 pmol. The agonists used were nitric oxide and nitroprusside, which have the same activity as endothelial-derived relaxing factor. Histamine, 5-hydroxytryptamine, platelet activating factor and carrageenan were the other agonists used. It is proposed that endothelin and EDRF act as local hormones produced by endothelial cells to control local vascular permeability.
Chander
C L
CL
Department of Experimental Pathology, St Bartholomew's Hospital Medical College, London, UK.
Moore
A R
AR
Desa
F M
FM
Howat
D
D
Willoughby
D A
DA
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D004730:Endothelium, Vascular / Q000201:enzymology / Q000502:physiology*; D006162:Guanylate Cyclase / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051381:Rats; D014020:Tissue Extracts / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects
D014020:Tissue Extracts; D006162:Guanylate Cyclase