Thrombotic microangiopathy in three patients with cured lymphoma.
Thrombotic microangiopathy (TM) occurred 14 to 27 months after last chemotherapy in two patients with diffuse large cell lymphoma and in one patient with Hodgkin's disease. Death from TM occurred in two patients who had no evidence of lymphoma at postmortem examination, and the lone survivor's disease is in complete clinical remission. All three patients had prominent arthritis. Occurrence of TM in non-Hodgkin's lymphoma has not previously been reported: its cause is uncertain; it may be to a late sequela of successful lymphoma chemotherapy.
Carey
R W
RW
Massachusetts General Hospital Hematology Oncology Unit, Boston.
Harris
N
N
D000368:Aged; D000369:Aged, 80 and over; D001168:Arthritis / Q000150:complications*; D002540:Cerebral Cortex / Q000473:pathology; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000209:etiology* / Q000473:pathology; D006689:Hodgkin Disease / Q000150:complications; D006801:Humans; D007668:Kidney / Q000473:pathology; D008223:Lymphoma / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D011696:Purpura, Thrombocytopenic / Q000097:blood / Q000209:etiology* / Q000473:pathology