title: Effect of natural peptide YY on pancreatic secretion and cholecystokinin release in conscious dogs.
abstract: The effects of natural peptide YY on pancreatic secretion under different stimulatory conditions and on fatty acid-induced cholecystokinin release were examined in five conscious dogs with pancreatic and gastric fistulas. Intravenous infusion of natural peptide YY at 1 and 0.2 microgram/kg/hr caused 60 and 40% inhibition of secretin- and cholecystokinin-stimulated secretion, respectively, and 40-50 and 20-40% inhibition of intraduodenal oleate stimulated secretion, respectively. A significant but transient decrease in the plasma cholecystokinin level was observed in response to peptide YY under oleate stimulation. The present study demonstrates that peptide YY has a potent inhibitory effect on both exogenously and endogenously stimulated pancreatic secretion and has a mild suppressive effect on fatty acid-induced cholecystokinin release suggesting that this peptide is an important colonic inhibitor of pancreatic secretion.
authors.affiliation: First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Hosotani
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Kogire
authors.forename: K
authors.initials: K
authors.lastname: Tatemoto
authors.forename: V
authors.initials: V
authors.lastname: Mutt
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: P L
authors.initials: PL
authors.lastname: Rayford
authors.forename: T
authors.initials: T
authors.lastname: Tobe
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002766:Cholecystokinin / Q000378:metabolism* / Q000494:pharmacology; D004285:Dogs; D005260:Female; D005768:Gastrointestinal Hormones / Q000494:pharmacology; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000008:administration & dosage / Q000494:pharmacology; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism; D019894:Peptide YY; D010455:Peptides / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D012633:Secretin / Q000494:pharmacology
chemical_list: D001639:Bicarbonates; D005768:Gastrointestinal Hormones; D009829:Oleic Acids; D010455:Peptides; D011506:Proteins; D019894:Peptide YY; D012633:Secretin; D019301:Oleic Acid; D002766:Cholecystokinin