title: Monocyte defect causes decreased autoMLR in multiple sclerosis patients.
abstract: We have recently demonstrated that peripheral blood monocytes from patients with multiple sclerosis (MS) have a defect in stimulating autologous and allogeneic T lymphocytes. This defect was found to correlate with disease activity. We report here that T4+ cells from MS patients proliferate weakly in the autologous mixed lymphocyte reaction (autoMLR). Furthermore, we provide direct proof that the depressed T4+ cell proliferation is due to the monocyte functional (stimulatory) defect.
authors.affiliation: Department of Immunology, Hellenic Anticancer Institute, Athens.
authors.forename: C N
authors.initials: CN
authors.lastname: Baxevanis
authors.forename: G J
authors.initials: GJ
authors.lastname: Reclos
authors.forename: P
authors.initials: P
authors.lastname: Arsenis
authors.forename: A
authors.initials: A
authors.lastname: Katsiyiannis
authors.forename: N
authors.initials: N
authors.lastname: Matikas
authors.forename: M
authors.initials: M
authors.lastname: Papamichail
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D009000:Monocytes / Q000276:immunology*; D009103:Multiple Sclerosis / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology