Reduced glutamate decarboxylase activity in the subthalamic nucleus in patients with tardive dyskinesia.
Glutamate decarboxylase (GAD) activity was measured in the nuclei of the basal ganglia in patients with neuroleptic-induced tardive dyskinesia (TD) and controls matched for age and premortem state. In five TD patients, who all had a sudden death, a significant decrease in GAD activity was found in the subthalamic nucleus (STN). The lowered GAD activity in the STN may represent a biochemical substrate for neuroleptic-induced TD.
Andersson
U
U
Psychiatric Research Center, Ulleråker Hospital, Uppsala, Sweden.
Häggström
J E
JE
Levin
E D
ED
Bondesson
U
U
Valverius
M
M
Gunne
L M
LM
D000368:Aged; D000369:Aged, 80 and over; D003645:Death, Sudden / Q000473:pathology; D004409:Dyskinesia, Drug-Induced / Q000473:pathology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000172:deficiency*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology; D013787:Thalamic Nuclei / Q000473:pathology*
D005968:Glutamate Decarboxylase