[Effects of chlordemethyldiazepam on blood cortisol during surgical stress].
The pre-operative plasma cortisol levels in 16 male patients undergoing plastic-reconstructive surgery were studied. 8 patients received chlordesmethyldiazepam 0.1 mg/kg-1 i.v. (group C), 8 sodium thiopental 5 mg/kg-1 i.v. (group T) in anaesthesia induction. All patients were premedicated by diazepam 0.15 mg/kg-1 by mouth 90 min before anaesthesia induction and atropine 0.007 mg/kg-1 i.v. just before induction, and received succinylcholine 1 mg/kg-1 i.v. and an endotracheal tube for mechanically controlled ventilation. Anaesthesia maintenance was assured by isoflurane 0.5-2.5% in a N2O/O2 (2/1) gas mixture. Blood samples were collected from each patient at the following times: 24 h before surgery (t0); 30 min after skin incision (t1); 30 min after extubation (t2). Significant variations of blood cortisol levels have not been shown.
D'Eramo
C
C
I Servizio Anestesia e Rianimazione, U.S.L. n. 4, Parma.
Tirelli
F
F
Maestri
D
D
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001569:Benzodiazepines; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000031:analogs & derivatives*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D003708:Nordazepam / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D011229:Preanesthetic Medication; D011897:Random Allocation; D013312:Stress, Physiological / Q000517:prevention & control*; D013514:Surgical Procedures, Operative
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D003708:Nordazepam; C013434:chlordesmethyldiazepam; D003975:Diazepam; D006854:Hydrocortisone
Effetti del clordemetildiazepam sulla cortisolemia in corso di stress chirurgico.