[Effects of preliminary fasting on the development of D-galactosamine-induced acute lesion of the liver in rats].
The effect of 48-hour preliminary fasting on the development of acute hepatitis in 24 h after the use of 1,855 mmol D-galactosamine per 1 kg bw has been studied on rats. Both intensification of dystrophic and necrotic processes in the liver and aggravation of ultrastructural changes and disorders have been observed. Concentrations of reduced glutathione in the liver and D-glucaric acid in the urine are not changed under the effect of intoxication.
Adzharov
D
D
Donchev
N
N
Kerimova
M
M
Naĭdenova
E
E
Borov
B
B
D000208:Acute Disease; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005215:Fasting; D005688:Galactosamine; D005977:Glutarates / Q000652:urine; D005978:Glutathione / Q000378:metabolism; D006965:Hyperplasia; D006984:Hypertrophy; D008099:Liver / Q000473:pathology; D008297:Male; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains
D005977:Glutarates; D005688:Galactosamine; D003577:Cytochrome P-450 Enzyme System; D005978:Glutathione; C035736:glutaric acid
Vliianie predvaritel'nogo golodaniia na razvitie ostrogo povrezhdeniiapecheni D-galaktozaminom u krys.