[Immunoregulatory disorders and activation of the immune system in dilated cardiomyopathy].
The level of immunoregulatory lymphocytic subpopulations (CD3-, CD4-, CD8-cells, CD4/SD8 ratio, IaDr-positive cells, SD16-cells), lymphocyte natural cytotoxicity (NCT), the concentration of serum interferon (IF), beta 2-microglobulin (beta 2-M) and neopterin were investigated in 30 patients with dilatative cardiomyopathy (DCMP). Immunoregulatory lymphocytic subpopulations were defined by indirect immunofluorescence using monoclonal antibodies to differentiating markers of BMA and OKT series. A decrease in SD4/SD8 ratio less than 1 was observed in 10 patients, an increase in SD4/SD8 ratio over 2.3 was observed in 5 patients. A significant rise of IaDr-positive cells, a decrease in NCT, an increase in the concentration of IF, beta 2-M and neopterin were observed. There was correlation of an increase in IF concentration, the number of IaDr-positive cells and an increase in the level of neopterin and beta 2-M. Signs of activation of the immune system were more frequently noted in patients with a decreased (less than 1) or increased CD4/CD8 ratio. The role of disorders of immunoregulation and activation of the immune system in DCMP pathogenesis was discussed.
Nasonov
E L
EL
Aleksandrova
L Z
LZ
Samsonov
M Iu
MIu
Aleksandrova
E N
EN
Gracheva
L A
LA
D000293:Adolescent; D000328:Adult; D001708:Biopterins / Q000031:analogs & derivatives / Q000276:immunology; D002311:Cardiomyopathy, Dilated / Q000209:etiology / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D007370:Interferon Type I / Q000276:immunology; D008297:Male; D008875:Middle Aged; D019798:Neopterin; D013601:T-Lymphocytes / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000276:immunology
D006684:HLA-DR Antigens; D007370:Interferon Type I; D001613:beta 2-Microglobulin; D001708:Biopterins; D019798:Neopterin
Narushenie immunoreguliatsii i aktivatsiia sistemy immuniteta pri dilatatsionnoĭ kardiomiopatii.