Comparative study of cathinone and amphetamine on brown adipose thermogenesis.
The effect of cathinone and amphetamine on brown adipose tissue thermogenesis and its modification with propranolol and timolol has been studied in rats. Both cathinone and amphetamine produced significant dose dependent increases in intracapsular brown adipose tissue (IBAT) and rectal temperatures. Amphetamine was found to be three times more potent as compared to cathinone, on a dose basis. Pretreatment of animals with propranolol and timolol individually inhibited cathinone and amphetamine induced hyperthermia. These findings suggest the involvement of beta adrenergic receptors in cathinone and amphetamine induced thermogenesis.
Tariq
M
M
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Islam
M W
MW
al-Meshal
I A
IA
el-Feraly
F S
FS
Ageel
A M
AM
D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism*; D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology*; D000661:Amphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013999:Timolol / Q000494:pharmacology
D000470:Alkaloids; C023665:cathinone; D013999:Timolol; D011433:Propranolol; D000661:Amphetamine