title: Active and latent forms of transforming growth factor beta activity in synovial effusions.
abstract: We have evaluated the possible involvement of TGF-beta in rheumatoid arthritis by assay of 16 cell-free synovial fluids for the presence of its active and "latent" forms. Evidence has been obtained for TGF-beta-like activity in synovial effusions by four criteria: (a) TGF-beta receptor competition, (b) soft-agar colony formation of AKR-2B and NRK-49F indicator cells, (c) immunological neutralization of the biological activity, and (d) biochemical activation of a latent form.
authors.affiliation: Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
authors.forename: R
authors.initials: R
authors.lastname: Fava
authors.forename: N
authors.initials: N
authors.lastname: Olsen
authors.forename: J
authors.initials: J
authors.lastname: Keski-Oja
authors.forename: H
authors.initials: H
authors.lastname: Moses
authors.forename: T
authors.initials: T
authors.lastname: Pincus
mesh_terms: D000937:Antigen-Antibody Reactions; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D001792:Blood Platelets / Q000502:physiology; D006801:Humans; D007717:Knee; D011869:Radioligand Assay; D013582:Synovial Fluid / Q000378:metabolism*; D015291:Transforming Growth Factors / Q000378:metabolism*
chemical_list: D015291:Transforming Growth Factors