title: Equilibrium binding of spermine and histamine to salmon sperm DNA and poly(dGdC).
abstract: Studies using the solute-enhanced phase partition technique demonstrate that the endogenous amines histamine and spermine bind to both salmon sperm DNA and poly(dGdC) in a markedly cooperative fashion. Both compounds exhibited DNA sequence-dependence effects in their mode of binding. The linear aliphatic spermine molecule binds more strongly than histamine to both DNA types.
authors.affiliation: Department of Chemistry, Rutgers University, Piscataway, NJ 08855.
authors.forename: S A
authors.initials: SA
authors.lastname: Winkle
authors.forename: P A
authors.initials: PA
authors.lastname: Crooks
mesh_terms: D000818:Animals; D004247:DNA / Q000378:metabolism*; D006632:Histamine / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D011089:Polydeoxyribonucleotides / Q000378:metabolism*; D012474:Salmon / Q000378:metabolism; D013094:Spermatozoa / Q000378:metabolism*; D013096:Spermine / Q000378:metabolism*
chemical_list: D011089:Polydeoxyribonucleotides; C019530:poly(dC-dG); D013096:Spermine; D006632:Histamine; D004247:DNA