Rhesus monkey apolipoprotein(a). Sequence, evolution, and sites of synthesis.
Human lipoprotein(a) is a low density lipoprotein-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) (apo(a)) which is disulfide-linked to apolipoprotein B-100. Sequencing of rhesus monkey apo(a) cDNA suggests that this protein, like human apo(a), is highly similar to plasminogen. Sequence data suggests that a plasminogen-like protease activity and kringle 1-, 2-, 3-, and 5-like domains are unnecessary for apo(a) function, but a highly repeated kringle four-like domain is important. Liver is the major site of apo(a) RNA synthesis; reduced amounts of message were also found in testes and brain. Co-expression with apoB-100 and plasminogen in rhesus tissues is not mandatory.
Tomlinson
J E
JE
Department of Cardiovascular Research, Genentech, Inc., South San Francisco, California 94080.
McLean
J W
JW
Lawn
R M
RM
D000595:Amino Acid Sequence; D000818:Animals; D001054:Apolipoproteins A / Q000096:biosynthesis / Q000235:genetics*; D001483:Base Sequence; D005075:Biological Evolution; D005796:Genes; D006801:Humans; D008099:Liver / Q000378:metabolism; D008251:Macaca / Q000235:genetics*; D008253:Macaca mulatta / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D010958:Plasminogen / Q000235:genetics; D011487:Protein Conformation; D012333:RNA, Messenger / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
D001054:Apolipoproteins A; D012333:RNA, Messenger; D010958:Plasminogen