title: The heterogeneity and differential expression of protein kinase C in nervous tissues.
abstract: Protein kinase C exists as a large family of multiple subspecies with subtle individual characteristics. This heterogeneity comes from different genes as well as from different splicings of a single RNA transcript. The members of this family have closely related structures with a high degree of homology. Biochemical studies have shown that their mode of activation and kinetic and catalytic properties differ slightly from one another. By using a combination of biochemical and immunocytochemical techniques, their differential regional and cellular expression have been shown in the nervous tissues. Each member of this enzyme family may have a specialized function in transducing various physiological and pathological signals into different cell types.
authors.affiliation: Department of Biochemistry, Kobe University School of Medicine, Japan.
authors.forename: U
authors.initials: U
authors.lastname: Kikkawa
authors.forename: K
authors.initials: K
authors.lastname: Ogita
authors.forename: M S
authors.initials: MS
authors.lastname: Shearman
authors.forename: K
authors.initials: K
authors.lastname: Ase
authors.forename: K
authors.initials: K
authors.lastname: Sekiguchi
authors.forename: Z
authors.initials: Z
authors.lastname: Naor
authors.forename: M
authors.initials: M
authors.lastname: Ido
authors.forename: Y
authors.initials: Y
authors.lastname: Nishizuka
authors.forename: N
authors.initials: N
authors.lastname: Saito
authors.forename: C
authors.initials: C
authors.lastname: Tanaka
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000201:enzymology*; D007700:Kinetics; D008969:Molecular Sequence Data; D009420:Nervous System / Q000201:enzymology*; D011493:Protein Kinase C / Q000235:genetics* / Q000378:metabolism
chemical_list: D011493:Protein Kinase C