Characteristics of butanol metabolism in alcohol dehydrogenase-deficient deermice.
Deermice lacking the low-Km alcohol dehydrogenase eliminated butan-1-ol, a substrate for microsomal oxidation but not for catalase, at 117 mumol/min per kg body wt. Microsomal fractions and hepatocytes metabolized butan-1-ol also (Vmax. = 6.7 nmol/min per nmol of cytochrome P-450, Km = 0.85 mM; Vmax. = 5.3 nmol/min per 10(6) cells, Km = 0.71 mM respectively). These results are consistent with alcohol oxidation by the microsomal system in these deermice.
Alderman
J A
JA
Alcohol Research and Treatment Center, Bronx VA Medical Center, NY.
Kato
S
S
Lieber
C S
CS
D000426:Alcohol Dehydrogenase / Q000172:deficiency* / Q000378:metabolism; D000818:Animals; D000440:Butanols / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D010542:Peromyscus
D000440:Butanols; D000426:Alcohol Dehydrogenase