title: Intestinal absorption of cephalosporin antibiotics: correlation between intestinal absorption and brush-border membrane transport.
abstract: The absorption of seven cephalosporin antibiotics from the in-situ intestinal loop at pH 7.4 and their transport by brush-border membrane vesicles in the presence of an inward H+ gradient ([pH]i = 7.5, [pH]o = 6.0) were examined. A good correlation was found between the intestinal absorption rate and the initial uptake rate by brush-border membrane vesicles. The data suggest that the transport study using intestinal brush-border membrane vesicles is useful as a model system for the intestinal absorption of beta-lactam antibiotics.
authors.affiliation: Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Hori
authors.forename: T
authors.initials: T
authors.lastname: Okano
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Maegawa
authors.forename: K
authors.initials: K
authors.lastname: Inui
mesh_terms: D000818:Animals; D002511:Cephalosporins / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D008297:Male; D008871:Microvilli / Q000378:metabolism*; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002511:Cephalosporins