title: Effects of indomethacin on bone ingrowth.
abstract: The effects of indomethacin, a nonsteroidal antiinflammatory agent, on bone ingrowth were studied using a rabbit animal model and a porous cylindrical implant system. Bone ingrowth was found to be independent of pore size in the range tested (0.6-1.0 mm). In the control (placebo-treated) group, there was a significant increase in bone ingrowth between the 2- and 8-week groups of animals. However, in the indomethacin-treated group, there was no increase in bone ingrowth with time.
authors.affiliation: Department of Materials Science, Medical University of South Carolina, Charleston.
authors.forename: J C
authors.initials: JC
authors.lastname: Keller
authors.forename: T M
authors.initials: TM
authors.lastname: Trancik
authors.forename: F A
authors.initials: FA
authors.lastname: Young
authors.forename: E
authors.initials: E
authors.lastname: St Mary
mesh_terms: D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D001842:Bone and Bones / Q000473:pathology; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D019736:Prostheses and Implants; D011817:Rabbits; D013997:Time Factors
chemical_list: D007213:Indomethacin