Secretion of liver lipase activity by periportal and perivenous hepatocytes.
Periportal and perivenous hepatocytes were separated by isopycnic centrifugation through Percoll, or selectively isolated by combined digitonin/collagenase perfusion. With either method, secretion of liver lipase activity was 2-2.5-fold higher in periportal than perivenous cells. This acinar heterogeneity parallels that of cholesterol de novo synthesis and bile formation reported previously.
Verhoeven
A J
AJ
Erasmus University Rotterdam, Department of Biochemistry, The Netherlands.
Jansen
H
H
D000818:Animals; D001646:Bile / Q000378:metabolism; D002469:Cell Separation; D002500:Centrifugation, Isopycnic; D002784:Cholesterol / Q000096:biosynthesis; D008049:Lipase / Q000378:metabolism*; D008099:Liver / Q000166:cytology / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002784:Cholesterol; D008049:Lipase