Obesity as a predictor of poor antibody response to hepatitis B plasma vaccine.
Factors associated with lack of antibody response to the hepatitis B virus plasma vaccine were retrospectively evaluated by means of a logistic regression in 194 previously seronegative staff members of a community hospital. All subjects had received three doses of vaccine by intramuscular buttock injection using a 1-in, 23-gauge needle. Overall, only 55.7% of subjects developed detectable antibody to hepatitis B surface antigen in serum after immunization. The weight-height index served as a surrogate measure of obesity. Predictors of poor immunogenic response to hepatitis B vaccine included higher weight-height index, older age, and vaccine batch. Sex, race, timing of vaccine doses, and timing of postimmunization determination of antibody to hepatitis B surface antigen were not predictors of vaccine efficacy.
Weber
D J
DJ
Rutala
W A
WA
Samsa
G P
GP
Santimaw
J E
JE
Lemon
S M
SM
D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D002081:Buttocks; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control; D006510:Hepatitis B Antibodies / Q000096:biosynthesis*; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines; D006744:Hospital Bed Capacity, 100 to 299; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D009657:North Carolina; D009765:Obesity / Q000276:immunology*; D009784:Occupational Diseases / Q000517:prevention & control; D010564:Personnel, Hospital; D012189:Retrospective Studies; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage / Q000276:immunology*
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D014761:Viral Hepatitis Vaccines