title: Alterations in oxygenation of cochlear endolymph during loud sound exposure.
abstract: The oxygen tension (pO2) of endolymph of the guinea pig cochlea was measured during exposure to loud sound (12 kHz or high-pass noise; 110 dB SPL up to 1 h duration). A small, but significant, steady decline in mean pO2 was observed after both pure tone and high-pass noise exposure. The extent of the change in pO2 varied from 0-50% in individual animals, compared with unexposed control animals. All exposed animals had an extensive loss of compound action potential (CAP) thresholds at frequencies of 8-30 kHz. However, there was no relationship between the extent of the change in pO2 of endolymph and CAP threshold loss.
authors.affiliation: Kresge Hearing Research Institute, University of Michigan Medical Center, Ann Arbor.
authors.forename: P R
authors.initials: PR
authors.lastname: Thorne
authors.forename: A L
authors.initials: AL
authors.lastname: Nuttall
mesh_terms: D000818:Animals; D003055:Cochlear Microphonic Potentials; D004710:Endolymph / Q000378:metabolism* / Q000502:physiology; D006168:Guinea Pigs; D007761:Labyrinthine Fluids / Q000378:metabolism*; D009925:Organ of Corti / Q000648:ultrastructure; D010101:Oxygen Consumption; D013016:Sound / Q000009:adverse effects*