Activation of mouse peritoneal macrophages by mannophosphoinositides of mycobacteria.
Peritoneal macrophages isolated from mannoside-methylated bovine serum albumin (MBSA)-immunized mice showed significantly enhanced phagocytosis of Mycobacterium smegmatis compared to control or MBSA-immunized groups. Immune macrophages also exhibited bacteriostatic activity against M. smegmatis. Pretreatment of mycobacteria with mannoside antibodies did not further alter the phagocytosis and bacteriostatic effect of immune macrophages.
Mehta
P K
PK
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Changigarh, India.
Khuller
G K
GK
D000818:Animals; D006027:Glycosides / Q000276:immunology*; D007114:Immunization; D008262:Macrophage Activation; D008362:Mannosides / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009161:Mycobacterium / Q000276:immunology*; D010529:Peritoneal Cavity / Q000166:cytology; D010587:Phagocytosis; D012710:Serum Albumin, Bovine / Q000276:immunology
D006027:Glycosides; D008362:Mannosides; D012710:Serum Albumin, Bovine