Coevolution of the major histocompatibility complex and the t-complex in the mouse. I. Generation and maintenance of high complementarity associations.
A quantitative model is developed to explore the effects of prezygotic and postzygotic incompatibility on the origin and maintenance of associations between the major histocompatibility complex (MHC) and the t-complex in the mouse. Incompatibility is represented by a reduction in the rate of conception or gestation of offspring derived from sperm bearing MHC antigens in common with the mother. Incompatibility encourages the evolution of associations from a state of complete independence between the two complexes by promoting the invasion of all novel antigens, including those that exhibit associations with the t-complex. Incompatibility can modify the relative numbers of antigens associated with each haplotype by actively promoting the exclusion or invasion of recombinants that bear formerly +-specific or t-specific antigens on the alternative haplotype. The results of the analysis indicate that the state of complete independence between the MHC and the t-complex is not preserved over evolutionary time in the presence of incompatibility. Further, the expression of incompatibility maintains fully associated states that include a single antigen associated with the t-haplotype and up to three to five antigens associated with the +-haplotype within a single population.
Uyenoyama
M K
MK
Department of Zoology, Duke University, Durham, North Carolina 27706.
D000818:Animals; D000943:Antigens, Differentiation / Q000235:genetics; D005075:Biological Evolution; D005796:Genes; D006239:Haplotypes; D006579:Heterozygote; D006649:Histocompatibility Antigens / Q000235:genetics / Q000276:immunology; D047908:Intracellular Signaling Peptides and Proteins; D008285:Major Histocompatibility Complex; D008433:Mathematics; D051379:Mice; D008869:Microtubule-Associated Proteins; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000235:genetics*; D012641:Selection, Genetic; D044767:Ubiquitin-Protein Ligases; D015053:Zygote / Q000166:cytology; D056427:t-Complex Genome Region
D000943:Antigens, Differentiation; D006649:Histocompatibility Antigens; D047908:Intracellular Signaling Peptides and Proteins; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins; C116196:PPP1R11 protein, human; D044767:Ubiquitin-Protein Ligases