[The expression of antigens, detectable with ICO-series monoclonal antibodies, on the surfaces of cells forming granulocyte and macrophage colonies in semiliquid agar].
The expression of antigens on granulocyte-macrophagal colony-forming cells of patients with nonhematological diseases was studied. Treatment of bone marrow cells with murine monoclonal antibodies ICO-1 and ICO-11 led to statistically significant inhibition of the number of growing colonies. Monoclonal antibodies ICO-02, ICO-10, ICO-GM-1 and ICO-G-2 had no such effect.
Savel'eva
E V
EV
Kharlamova
L A
LA
Baryshnikov
A Iu
AIu
Agafonov
V A
VA
Tupitsyn
N N
NN
D000362:Agar; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000943:Antigens, Differentiation / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D003165:Complement System Proteins / Q000276:immunology; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D013234:Stem Cells / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D000954:Antigens, Surface; D000362:Agar; D003165:Complement System Proteins
Ekspressiia antigenov, vyiavliaemykh monoklonal'nymi antitelami serii IKO, na poverkhnosti kletok, obrazuiushchikh granulotsitarnye i makrofagal'nye kolonii v poluzhidkom agare.