Bivalent ligand type beta-adrenolytics related to practolol.
The synthesis and pharmacological evaluation of a number of symmetrical bivalent ligand type beta-adrenolytics related to practolol are reported. The best results have been observed with N,N'-bis[3-[2-hydroxy-3-[1-methylethyl)amino]propoxy]phenyl] ethanediamide.
Rampa
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A
Department of Pharmaceutical Sciences, University of Bologna, Italy.
Da Re
P
P
Valenti
P
P
Frigeni
V
V
Sala
R
R
Della Bella
D
D
D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D015195:Drug Design; D005260:Female; D006168:Guinea Pigs; D007022:Hypotension / Q000139:chemically induced; D007536:Isomerism; D007545:Isoproterenol / Q000037:antagonists & inhibitors; D008297:Male; D011217:Practolol / Q000031:analogs & derivatives* / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013610:Tachycardia / Q000139:chemically induced
D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D007545:Isoproterenol; D011217:Practolol