Modelling basic features of specificity in DNA-aureolic acid-derived antibiotic interactions.
The nonintercalative groove binding of a simplified model of olivomycin, to sequences d(CGCGCGC)2, d(TATATAT)2, and d(CICICIC)2 is investigated. A significant preference is displayed for the minor groove of the d(CG) sequence. This is due predominantly to the formation of H-bonds between the hydroxyl groups on the aglycone of the drug and the 2-amino group of the central guanine of the oligonucleotide.
Chen
K X
KX
Institut de Biologie Physico-Chimique, Laboratoire de Biochimie Théorique associé au CNRS, Paris, France.
Gresh
N
N
Hui
X
X
Pullman
B
B
Zakrzewska
K
K
D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000378:metabolism*; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D009848:Olivomycins / Q000378:metabolism*; D013816:Thermodynamics
D009848:Olivomycins; D004247:DNA