Enhanced natriuretic and hypotensive responsiveness to alpha-human atrial natriuretic polypeptide (alpha-hANP) in SHR.
Natriuretic and hypotensive effects of synthetic alpha-human atrial natriuretic polypeptide (alpha-hANP) were investigated in anesthetized spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). The renal excretory and hypotensive effects of alpha-hANP were strengthened in a dose-dependent manner in both strains of rat. The natriuretic response to three doses of alpha-hANP (0.3, 1.0 and 3.0 micrograms/kg) were significantly greater in SHR than in WKY. These results suggest that atrial natriuretic polypeptide may play some role in water-electrolyte balance and control of blood pressure in SHR.
Kondo
K
K
Kida
O
O
Kangawa
K
K
Matsuo
H
H
Tanaka
K
K
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004231:Diuresis / Q000187:drug effects*; D006973:Hypertension / Q000503:physiopathology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013997:Time Factors
D009320:Atrial Natriuretic Factor