title: Phenelfamycins, a novel complex of elfamycin-type antibiotics. III. Activity in vitro and in a hamster colitis model.
abstract: Phenelfamycins A, B, C, E, F and unphenelfamycin make up a recently isolated group of elfamycin-type antibiotics. All of the phenelfamycins were active against Gram-positive anaerobes, including Clostridium difficile. Phenelfamycin A was also active in vitro against Neisseria gonorrhoeae and Streptococci. Phenelfamycin A was found to be effective in prolonging the survival of hamsters in an animal model of C. difficile enterocolitis. After oral administration of phenelfamycin A to hamsters, antibiotic was detected in the caecal contents but not in the blood.
authors.affiliation: Anti-infective Research Division, Abbott Laboratories, Illinois.
authors.forename: R N
authors.initials: RN
authors.lastname: Swanson
authors.forename: D J
authors.initials: DJ
authors.lastname: Hardy
authors.forename: N L
authors.initials: NL
authors.lastname: Shipkowitz
authors.forename: C W
authors.initials: CW
authors.lastname: Hanson
authors.forename: N R
authors.initials: NR
authors.lastname: Ramer
authors.forename: L J
authors.initials: LJ
authors.lastname: Coen
authors.forename: P B
authors.initials: PB
authors.lastname: Fernandes
mesh_terms: D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D003015:Clostridium Infections / Q000188:drug therapy*; D006224:Cricetinae; D004760:Enterocolitis / Q000188:drug therapy*; D008297:Male; D008647:Mesocricetus; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C058743:phenelfamycin F; C058741:phenelfamycin E; C058742:unphenelfamycin; C058737:phenelfamycin A; C058739:phenelfamycin B; C058740:phenelfamycin C; D014640:Vancomycin