title: 5-Methoxypsoralen increases evening sleepiness in humans: possible involvement of the melatonin secretion.
abstract: The acute and short-term effect of 5-methoxypsoralen (5-MOP) on daytime sleepiness was investigated in 12 healthy subjects according to a double-blind cross-over design. 5-MOP (40 mg/day) or placebo was orally administered (one week each) at 16.00 h. 5-MOP significantly increases daytime sleepiness 4 to 5 h after administration without affecting the subsequent sleep efficiency and duration. We found a positive correlation between sleepiness and melatonin levels. Our findings suggest that the melatonin secretion may play a role in the effect of 5-MOP on sleepiness in humans.
authors.affiliation: Clinique de psychiatrie et de psychologie médicale, Hôpital Pasteur, Nice, France.
authors.forename: E
authors.initials: E
authors.lastname: Souêtre
authors.forename: E
authors.initials: E
authors.lastname: Salvati
authors.forename: J L
authors.initials: JL
authors.lastname: Belugou
authors.forename: B
authors.initials: B
authors.lastname: Krebs
authors.forename: G
authors.initials: G
authors.lastname: Darcourt
mesh_terms: D000078223:5-Methoxypsoralen; D000328:Adult; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008550:Melatonin / Q000097:blood / Q000378:metabolism*; D008730:Methoxsalen / Q000009:adverse effects / Q000494:pharmacology*; D012890:Sleep; D012894:Sleep Stages / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000078223:5-Methoxypsoralen; D008550:Melatonin; D008730:Methoxsalen