title: Is proximal pancreatoduodenectomy with pyloric preservation superior to total pancreatectomy?
abstract: The records of all patients who underwent pylorus-preserving pancreatic resection (29 subtotal and 4 total pancreatectomies) during a 10-year period at the Mayo Clinic were reviewed. Thirty-day operative mortality was 6%. Early postoperative morbidity occurred in 45% of patients and necessitated reoperation in four patients. One patient had a hemorrhage from a marginal ulcer in the early postoperative period. The incidence of late postoperative morbidity was 18%. Marginal ulcers developed in the late postoperative period in three additional patients, for an overall incidence of 13%. One patient underwent vagotomy and pyloroplasty because of intractable bleeding 2 years after initial operation. The 29 patients who underwent pylorus-preserving pancreatoduodenectomy (PPW) were compared (retrospectively) with 200 patients who had undergone standard pancreatoduodenectomy (Whipple operation) during the same 10-year period. The overall incidences of marginal ulcer were 10% in the PPW group and 5% in the Whipple group; the incidences of delayed gastric emptying were similar in these groups. We believe that caution is warranted in the use of PPW, as yet an unproved procedure.
authors.affiliation: Section of Gastroenterologic and General Surgery, Mayo Clinic, Rochester, Minn 55905.
authors.forename: M K
authors.initials: MK
authors.lastname: McAfee
authors.forename: J A
authors.initials: JA
authors.lastname: van Heerden
authors.forename: M A
authors.initials: MA
authors.lastname: Adson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004386:Duodenum / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005774:Gastrostomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000009:adverse effects / Q000379:methods*; D011183:Postoperative Complications / Q000209:etiology; D011708:Pylorus; D013270:Stomach / Q000502:physiology; D013276:Stomach Ulcer / Q000209:etiology