title: Treatment of protracted acute type B hepatitis with recombinant alpha-A-interferon. A pilot study.
abstract: Six individuals with protracted acute type B hepatitis were treated with recombinant alpha-A-interferon for 12 weeks. Two females eliminated the HBV completely, while 4 males did not respond. Response was preceded by a flare-up of the liver disease. It appears that responses to interferon are not higher in protracted acute type B hepatitis than in progressed chronic active hepatitis B. This assumption has to be proven in larger studies on a statistical basis.
authors.affiliation: I. Medical Department, University of Mainz, F.R.G.
authors.forename: G
authors.initials: G
authors.lastname: Hess
authors.forename: S
authors.initials: S
authors.lastname: Rossol
authors.forename: R
authors.initials: R
authors.lastname: Voth
authors.forename: C
authors.initials: C
authors.lastname: Weber
authors.forename: N
authors.initials: N
authors.lastname: Drees
authors.forename: K H
authors.initials: KH
authors.lastname: Meyer zum Büschenfelde
mesh_terms: D000208:Acute Disease; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006509:Hepatitis B / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006513:Hepatitis B e Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D010865:Pilot Projects; D011994:Recombinant Proteins
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D007370:Interferon Type I; D011994:Recombinant Proteins