title: Growth of prolactinoma despite lowering of serum prolactin by bromocriptine.
abstract: Four patients with macroprolactinomas treated with bromocriptine had tumor growth and visual loss despite marked reduction in their serum prolactin levels. Explanations for this dissociation of tumor growth and prolactin measurement might include noncompliance. Patients treated with bromocriptine require periodic examination by computed tomographic scan or magnetic resonance imaging and neuro-ophthalmological evaluation in addition to monitoring of serum prolactin.
authors.affiliation: Department of Neurology, New York University Medical Center, New York.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kupersmith
authors.forename: D
authors.initials: D
authors.lastname: Kleinberg
authors.forename: F A
authors.initials: FA
authors.lastname: Warren
authors.forename: G
authors.initials: G
authors.lastname: Budzilovitch
authors.forename: P
authors.initials: P
authors.lastname: Cooper
mesh_terms: D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010902:Pituitary Gland / Q000473:pathology; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D011388:Prolactin / Q000097:blood*; D015175:Prolactinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity / Q000187:drug effects; D014794:Visual Fields / Q000187:drug effects
chemical_list: D001971:Bromocriptine; D011388:Prolactin