title: Controlled mechanical stimulation in the treatment of tibial fractures.
abstract: Although it is known that the mechanical environment affects the fracture healing process, the optimal conditions for the different stages of healing have not been defined. In the present studies, the influence of applying a very short period of axial micromovement with defined characteristics to healing fractures has been studied both in simulated and clinical tibial fractures. The fracture healing process is seen to be acutely sensitive to small periods of daily strain applied axially within two weeks of fracture. There are boundaries of strain magnitude and force of application of applied movement that, if exceeded, inhibit the healing process. The application of appropriate applied strain to clinical tibial fractures at a time shortly after injury, when most patients would be very inactive, appears to enhance the healing process when using external skeletal fixation.
authors.affiliation: Nuffield Orthopedic Centre, University of Oxford, England.
authors.forename: J
authors.initials: J
authors.lastname: Kenwright
authors.forename: A E
authors.initials: AE
authors.lastname: Goodship
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002146:Bony Callus / Q000502:physiology; D004548:Elasticity; D005592:Fracture Fixation / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008903:Minerals / Q000032:analysis; D009984:Orthopedic Fixation Devices; D010812:Physical Stimulation; D012756:Sheep; D013314:Stress, Mechanical; D013978:Tibial Fractures / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D014945:Wound Healing
chemical_list: D008903:Minerals