Support for adrenaline-hypertension hypothesis: 18 hour pressor effect after 6 hours adrenaline infusion.
In a double blind, crossover study 6 h infusions of adrenaline (15 ng/kg/min; 1 ng = 5.458 pmol), noradrenaline (30 ng/kg/min; 1 ng = 5.911 pmol), and a 5% dextrose solution (5.4 ml/h), were given to ten healthy volunteers in random order 2 weeks apart. By means of intra-arterial ambulatory monitoring the haemodynamic effects were followed for 18 h after the infusions were stopped. Adrenaline, but not noradrenaline, caused a delayed and protracted pressor effect. Over the total postinfusion period systolic and diastolic arterial pressure were 6 (SEM 2)% and 7 (2)%, respectively, higher than after dextrose infusion (ANOVA, p less than 0.001). Thus, "stress" levels of adrenaline (230 pg/ml) for 6 h cause a delayed and protracted pressor effect. These findings are strong support for the adrenaline-hypertension hypothesis in man.
Blankestijn
P J
PJ
Department of Internal Medicine I, Erasmus University Rotterdam, The Netherlands.
Man in't Veld
A J
AJ
Tulen
J
J
van den Meiracker
A H
AH
Boomsma
F
F
Moleman
P
P
Ritsema van Eck
H J
HJ
Derkx
F H
FH
Mulder
P
P
Lamberts
S J
SJ
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005947:Glucose / Q000008:administration & dosage; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage / Q000097:blood; D012083:Renin / Q000097:blood
D012083:Renin; D005947:Glucose; D009638:Norepinephrine; D004837:Epinephrine