Studies of serum lipids in hypercholesterolaemic rabbits treated with doxazosin.
Serum lipids were studied in hypercholesterolaemic rabbits treated with the selective alpha 1-adrenoreceptor antagonist doxazosin. Hypercholesterolaemia had been induced by cholesterol feeding which raised mean (+/- SEM) total serum cholesterol from 1.4 (+/- 0.1) mmol/l to 84.1 (+/- 3.6) mmol/l. A cross-over design was used to compare the effect of doxazosin with placebo in 20 rabbits of which 16 completed the study. Doxazosin (2 mg/kg) or placebo vehicle was administered subcutaneously once daily for three weeks. Compared with placebo, doxazosin produced an 8.6% greater reduction in total serum cholesterol. This difference did not, however, reach statistical significance.
Leren
T P
TP
Department of Medical Genetics, City of Oslo, Blindern, Norway.
Berg
K
K
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D002682:Chinchilla; D002784:Cholesterol / Q000008:administration & dosage / Q000097:blood; D017292:Doxazosin; D004353:Drug Evaluation, Preclinical; D005260:Female; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008055:Lipids / Q000097:blood*; D011224:Prazosin / Q000031:analogs & derivatives* / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D008055:Lipids; D002784:Cholesterol; D017292:Doxazosin; D011224:Prazosin