Experimental chemotherapy and radiotherapy to paratesticular rhabdomyosarcoma.
Experimental chemotherapy and radiotherapy were tried in transplanted tumors derived from a paratesticular embryonal rhabdomyosarcoma. There was no significant difference on the therapeutic effect between a combination chemotherapy composed of vincristine, actinomycin D and cyclophosphamide, so-called "VAC" regimen, and a single therapy of radiation. However, morphologic analyses suggest that VAC is effective in embryonal rhabdomyosarcomas in which undifferentiated rhabdomyoblasts predominate, while radiotherapy is preferable for those containing variously differentiated rhabdomyoblasts.
Motoyama
T
T
Department of Pathology, Niigata University School of Medicine, Japan.
Watanabe
H
H
Watanabe
T
T
Yamamoto
T
T
D000293:Adolescent; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D005834:Genital Neoplasms, Male / Q000628:therapy*; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011817:Rabbits; D011867:Radioisotope Teletherapy; D012208:Rhabdomyosarcoma / Q000628:therapy*; D013085:Spermatic Cord; D014750:Vincristine / Q000008:administration & dosage
D003037:Cobalt Radioisotopes; D003609:Dactinomycin; D014750:Vincristine; D003520:Cyclophosphamide