Is ischemia implicated in chronic multifocal demyelinating neuropathy?
We describe a patient with chronic multifocal demyelinating neuropathy associated with persistent conduction block. Multifascicular lesions in sural nerve included a complete loss of myelinated fibers, demyelination, remyelination, onion bulb formation, and axonal attenuation. On the basis of these morphometric results we hypothesize that nerve ischemia may be involved in the pathogenesis of chronic multifocal demyelinating neuropathy.
Nukada
H
H
Department of Medicine, University of Otago, Dunedin, New Zealand.
Pollock
M
M
Haas
L F
LF
D002545:Brain Ischemia / Q000150:complications*; D003711:Demyelinating Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009422:Nervous System Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D009431:Neural Conduction; D013497:Sural Nerve / Q000473:pathology