Fatal haemopathological consequences of general anaesthesia.
A previously healthy 63-yr-old female died following an anaphylactoid response to anaesthesia with thiopentone and suxamethonium. Postmortem findings strongly suggested that disseminated intravascular coagulation played a significant role in her death. The local mechanism behind the reaction is unknown, but the formation of thiopentone-suxamethonium colloid aggregates during induction, may have led to "aggregate anaphylaxis".
Wright
P J
PJ
Department of Anaesthetics, Royal Hallamshire Hospital, Sheffield.
Shortland
J R
JR
Stevens
J D
JD
Parsons
M A
MA
Watkins
J
J
D000707:Anaphylaxis / Q000139:chemically induced*; D000768:Anesthesia, General / Q000009:adverse effects*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013390:Succinylcholine / Q000009:adverse effects*; D013874:Thiopental / Q000009:adverse effects*
D013390:Succinylcholine; D013874:Thiopental