Reciprocal zones of excitation and inhibition in the neostriatum.
Single-unit activity was recorded in the rat neostriatum at different distances from the point of an infusion of either glutamate or serotonin. In each case, firing rate at the distant site (0.8-1.5 mm) was the mirror image of that at the near site (0.1-0.3 mm). These reciprocal changes were blocked by a subsequent injection of haloperidol, a dopamine antagonist. It appears that a lateral inhibitory network, intrinsic to the neostriatum and possibly modulated by dopamine, plays an important role in the operation of the neostriatum.
Rebec
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Department of Psychology, Indiana University, Bloomington 47405.
Curtis
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SD
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology*
D005971:Glutamates; D012701:Serotonin; D018698:Glutamic Acid; D006220:Haloperidol