title: [Retard morphine in the long-term therapy of severe tumor pain].
abstract: 35 patients with severe cancer pain received oral retard morphine. Pain reduction was achieved in each case; duration of effectiveness was between 8 and 12 hours. Mean daily dose was 230 mg morphine, but in individual cases the maximal daily dose had to be over 800 mg. The Karnofsky index of physical capacity was increased in all patients. The main side effect was constipation, which actually increased in the course of treatment. On the other hand, nausea and vomiting decreased after a few weeks. No dependence developed in any of the patients. This form of morphine medication thus was effective over long periods and it has become an important part in the range of strongly effective analgesics.
authors.affiliation: Universitätsklinik für Anaesthesiologie, Intensiv- und Schmerztherapie, Berufsgenossenschaftliche Krankenanstalten, Bergmannsheil Bochum.
authors.forename: M
authors.initials: M
authors.lastname: Zenz
authors.forename: M
authors.initials: M
authors.lastname: Strumpf
authors.forename: M
authors.initials: M
authors.lastname: Tryba
authors.forename: E
authors.initials: E
authors.lastname: Röhrs
authors.forename: B
authors.initials: B
authors.lastname: Steffmann
mesh_terms: D000328:Adult; D000368:Aged; D003692:Delayed-Action Preparations; D004341:Drug Evaluation; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D009021:Morphine Dependence / Q000453:epidemiology; D009369:Neoplasms / Q000150:complications*; D010147:Pain Measurement; D010148:Intractable Pain / Q000188:drug therapy* / Q000209:etiology; D011788:Quality of Life; D013607:Tablets; D013997:Time Factors
chemical_list: D003692:Delayed-Action Preparations; D013607:Tablets; D009020:Morphine
vernacular_title: Retardiertes Morphin zur Langzeittherapie schwerer Tumorschmerzen.