The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man.
The data establish linkage in both sexes for LDLR:LW (zeta = 8.43 at theta = 0.00) and in the male for LDLR:LU (zeta = 3.31 at theta = 0.00) and for LW:APOC2 (zeta = 3.90 at theta = 0.00). They confirm LDLR:C3 and APOC2:LU linkage in both sexes, and LW:LU linkage in the male. The loci constitute two tightly linked gene clusters, LDLR, C3, LW and APOC2, LU, SE, distinguished by measurable linkage in female meioses within but not between clusters. Argument is supported for a 19p13.2-cen position for LW and a long arm position for LU and SE.
Lewis
M
M
Department of Pediatrics, University of Manitoba, Winnipeg, Canada.
Kaita
H
H
Coghlan
G
G
Philipps
S
S
Belcher
E
E
McAlpine
P J
PJ
Coopland
G R
GR
Woods
R A
RA
D053304:Apolipoprotein C-II; D001056:Apolipoproteins C / Q000235:genetics; D002888:Chromosomes, Human, Pair 19; D003176:Complement C3 / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000235:genetics; D008126:Lod Score; D008188:Lutheran Blood-Group System / Q000235:genetics; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D011973:Receptors, LDL / Q000235:genetics; D012204:Rh-Hr Blood-Group System / Q000235:genetics
D053304:Apolipoprotein C-II; D001056:Apolipoproteins C; D003176:Complement C3; D007071:Immunoglobulin A, Secretory; D008188:Lutheran Blood-Group System; D011973:Receptors, LDL; D012204:Rh-Hr Blood-Group System