Nicardipine after spinal cord compression in the lamb.
To study the effects of the calcium channel blocker nicardipine on spinal cord blood flow and spinal evoked potentials, the following study was undertaken. After cord compression, which was productive of paraparesis, nicardipine was administered intravenously in 10 anesthetized lambs. Ten control animals were subjected to compression but received saline instead. Nicardipine produced a significant decrease in mean arterial pressure when compared to the control group. Thirty minutes after compression, spinal cord blood flow also was lower in the nicardipine group compared with controls. Spinal evoked potentials did not recover after compression in either group.
Hitchon
P W
PW
Department of Surgery, University of Iowa Hospital, Iowa City 52242.
Hansen
T
T
McKay
T
T
Girton
R A
RA
Dyste
G N
GN
Sokoll
M D
MD
D000818:Animals; D005071:Evoked Potentials / Q000187:drug effects; D006439:Hemodynamics; D009529:Nicardipine / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D012756:Sheep; D013116:Spinal Cord / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology; D013117:Spinal Cord Compression / Q000503:physiopathology*
D009529:Nicardipine