Translational regulation of myelin protein synthesis by steroids.
Various steroids, including glucocorticoids, were observed to exert a direct effect on the rates of translation of several myelin-protein specific transcripts in a cell-free, reticulocyte lysate system. Hydrocortisone caused a twofold stimulation in the translation of mRNAs of myelin basic protein and proteolipid protein. It inhibited the translation of 2',3'-cyclic nucleotide 3'-phosphodiesterase mRNA by 50%, and had no effect on the translation of a number of other mRNAs. The data suggest that steroid-mediated translational regulation may serve as a novel mechanism to modulate the expression of myelin protein genes at the translational level.
Verdi
J M
JM
Mental Retardation Research Center, UCLA Center for the Health Sciences.
Kampf
K
K
Campagnoni
A T
AT
D000818:Animals; D002474:Cell-Free System; D005470:Fluorometry; D051379:Mice; D008810:Mice, Inbred C57BL; D009185:Myelin Proteins / Q000096:biosynthesis*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D013256:Steroids / Q000494:pharmacology*
D009185:Myelin Proteins; D012333:RNA, Messenger; D013256:Steroids