title: Application of immunohistochemistry to the isolated mucosa of the mouse gastrointestinal tract, with special reference to somatostatin cells.
abstract: In the present study, in order to easily grasp whole images of somatostatin (D) cells, the isolated mucosa of the mouse gastrointestinal tract was immunohistochemically treated. The present study revealed that: (1) in the stomach, small-intestinal villi and colon, about 20% of the D cells extrude basal cytoplasmic processes, showing terminal expansions in many cases; on the other hand, in the crypts of the small intestine, few D cells possess basal processes, and (2) in the stomach, there is no determined tendency in the direction of the basal processes of the D cells; on the other hand, in the small-intestinal villi and colon, most D cell basal processes run toward the villus base and colon crypt bottoms. The direction of the basal processes of the D cells in the gastrointestinal tract seems to be mostly in favor of the migration pattern of epithelial cells described previously. It is likely that, if the targets of the D cells are near the D cells, the basal process is not necessary for local secretion of somatostatin. During migration, however, D cells might extrude basal processes to keep relationships with their targets.
authors.affiliation: Department of Anatomy, Asahikawa Medical College, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Satoh
authors.forename: Y
authors.initials: Y
authors.lastname: Oomori
authors.forename: K
authors.initials: K
authors.lastname: Ishikawa
authors.forename: T
authors.initials: T
authors.lastname: Satoh
authors.forename: K
authors.initials: K
authors.lastname: Ono
mesh_terms: D000818:Animals; D004064:Digestive System / Q000032:analysis / Q000166:cytology* / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009092:Mucous Membrane / Q000032:analysis / Q000166:cytology / Q000378:metabolism; D013004:Somatostatin / Q000032:analysis / Q000378:metabolism*
chemical_list: D013004:Somatostatin