Simultaneous use of multiple serologic tests in assessing clinical activity in systemic lupus erythematosus.
Ten technics for quantifying and qualifying anti-DNA antibodies were correlated with manifestations of disease activity in sera from 27 patients with systemic lupus erythematosus (SLE) using both a simple and a stepwise regression. In the stepwise analysis, a panel consisting of four of these tests provided maximal correlation (r = 0.68) with clinical status. Low IgM anti-DNA was a significant correlate of nephritis in stepwise discriminant function analysis. Multivariate analysis can offer distinct advantages over simple correlation in understanding the role of serological abnormalities in disease expression in SLE.
Cronin
M E
ME
Department of Medicine, Medical College of Wisconsin, Milwaukee 53226.
Leair
D W
DW
Jaronski
S
S
Lightfoot
R W
RW
D001323:Autoantibodies / Q000276:immunology*; D003168:Complement Fixation Tests; D004247:DNA / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology*; D008181:Lupus Nephritis / Q000276:immunology; D012698:Serologic Tests
D001323:Autoantibodies; D004247:DNA