title: [Effect of ionol on carcinogenesis in the kidneys].
abstract: The effect of treatment with an antioxidant--ionol (2,6-di-tert-butyl, 4-methylphenol)--on nitrosodimethylamine-induced carcinogenesis was studied. Large doses of ionol were found to inhibit tumor development in the kidney. This also involved intensification of spontaneous peroxidation of renal cortical membrane cell lipids which in turn was inhibited when additional stimulation with iron was carried out.
authors.forename: E P
authors.initials: EP
authors.lastname: Kozhevnikova
authors.forename: N M
authors.initials: NM
authors.lastname: Beliaeva
authors.forename: G A
authors.initials: GA
authors.lastname: Matchin
authors.forename: V N
authors.initials: VN
authors.lastname: Kirillov
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Kopylov
mesh_terms: D000818:Animals; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D004128:Dimethylnitrosamine; D004353:Drug Evaluation, Preclinical; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D013997:Time Factors
chemical_list: D010743:Phospholipids; D002084:Butylated Hydroxytoluene; D008315:Malondialdehyde; D004128:Dimethylnitrosamine
vernacular_title: Vliianie ionola na kantserogenez v pochkakh.