Phenelfamycins, a novel complex of elfamycin-type antibiotics. III. Activity in vitro and in a hamster colitis model.
Phenelfamycins A, B, C, E, F and unphenelfamycin make up a recently isolated group of elfamycin-type antibiotics. All of the phenelfamycins were active against Gram-positive anaerobes, including Clostridium difficile. Phenelfamycin A was also active in vitro against Neisseria gonorrhoeae and Streptococci. Phenelfamycin A was found to be effective in prolonging the survival of hamsters in an animal model of C. difficile enterocolitis. After oral administration of phenelfamycin A to hamsters, antibiotic was detected in the caecal contents but not in the blood.
Swanson
R N
RN
Anti-infective Research Division, Abbott Laboratories, Illinois.
Hardy
D J
DJ
Shipkowitz
N L
NL
Hanson
C W
CW
Ramer
N R
NR
Coen
L J
LJ
Fernandes
P B
PB
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D003015:Clostridium Infections / Q000188:drug therapy*; D006224:Cricetinae; D004760:Enterocolitis / Q000188:drug therapy*; D008297:Male; D008647:Mesocricetus; D014640:Vancomycin / Q000627:therapeutic use
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C058743:phenelfamycin F; C058741:phenelfamycin E; C058742:unphenelfamycin; C058737:phenelfamycin A; C058739:phenelfamycin B; C058740:phenelfamycin C; D014640:Vancomycin