title: Optic disc cupping: four year follow-up from the WESDR.
abstract: Change in optic disc cupping was evaluated in a 4-year follow-up of a well defined cohort of people with diabetes mellitus. Cup-to-disc ratios were computed for both vertical and horizontal diameters of each eye at the baseline and 4-year follow-up examinations. Graders were masked as to the identity of participants and to the dates of the photographs. Increases of at least 0.1 between baseline and follow-up were used as clinically significant change in the ratios. None of the following factors at baseline were consistent predictors of such a change: intraocular pressure, age, duration of diabetes, hypertension or severity of diabetic retinopathy. People who developed proliferative retinopathy by the follow-up examination were not more likely to have such an increase in ratio at the follow-up. We conclude that clinically significant increases in cup-to-disc ratio cannot be consistently predicted in people with diabetes from the risk factors evaluated with the grading system used in this study.
authors.affiliation: Department of Ophthalmology, University of Wisconsin Medical School, Madison.
authors.forename: B E
authors.initials: BE
authors.lastname: Klein
authors.forename: S E
authors.initials: SE
authors.lastname: Moss
authors.forename: Y L
authors.initials: YL
authors.lastname: Magli
authors.forename: R
authors.initials: R
authors.lastname: Klein
authors.forename: C
authors.initials: C
authors.lastname: Hoyer
authors.forename: J
authors.initials: J
authors.lastname: Johnson
mesh_terms: D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000473:pathology; D003930:Diabetic Retinopathy / Q000150:complications / Q000473:pathology; D005500:Follow-Up Studies; D005901:Glaucoma / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D009898:Optic Disk / Q000473:pathology*; D012044:Regression Analysis; D012307:Risk Factors