Human immunodeficiency virus type 1 antigen in cerebrospinal fluid. Correlation with clinical neurologic status.
Human immunodeficiency virus type-1 (HIV-1) antigen was assayed in paired serum/cerebrospinal fluid (CSF) specimen from 85 adults and 58 children with acquired immunodeficiency syndrome and was compared with clinical neurological status. A quantitative comparison of HIV-1 antigen levels in matched serum and CSF specimens indicated that HIV-1 antigen expression in these compartments is independent and is correlated with acquired immunodeficiency syndrome dementia complex in adults and progressive encephalopathy in children. In a longitudinal study (n = 47), 16 patients tested positive for HIV-1 antigen in the CSF before (n = 2) or coincident (n = 14) with neurological deterioration. Six patients who tested positive for HIV-1 antigen in the CSF remained neurologically normal for a median duration of follow-up of 11 months. Six of 25 patients who tested negative for HIV-1 antigen in the CSF, subsequently showed neurological deterioration. These data indicate that HIV-1 antigen expression in the CSF is not useful in predicting neurological deterioration.
Portegies
P
P
Department of Neurology, University of Amsterdam, The Netherlands.
Epstein
L G
LG
Hung
S T
ST
de Gans
J
J
Goudsmit
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid* / Q000150:complications; D001927:Brain Diseases / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003704:Dementia / Q000209:etiology; D015488:HIV Antigens / Q000134:cerebrospinal fluid*; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D009422:Nervous System Diseases / Q000209:etiology
D015488:HIV Antigens