title: Metabolism and nephrotoxicity of tetralin in male Fischer 344 rats.
abstract: Tetralin, a component of fuels, solvents, and varnishes, is metabolized in male Fischer 344 rats to 1-tetralol, 2-tetralol, 2-hydroxyl-1-tetralone, 4-hydroxyl-1-tetralone, 1,2-tetralindiol, and 1,4-tetralindiol. Rats treated with tetralin demonstrated the classic lesions of hydrocarbon-induced nephropathy.
authors.affiliation: Department of Chemistry, Wright State University, Dayton, Ohio 45435.
authors.forename: M P
authors.initials: MP
authors.lastname: Servé
authors.forename: B M
authors.initials: BM
authors.lastname: Llewelyn
authors.forename: K O
authors.initials: KO
authors.lastname: Yu
authors.forename: G M
authors.initials: GM
authors.lastname: McDonald
authors.forename: C T
authors.initials: CT
authors.lastname: Olson
authors.forename: D W
authors.initials: DW
authors.lastname: Hobson
mesh_terms: D000818:Animals; D002849:Chromatography, Gas; D004781:Environmental Exposure; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000652:urine*; D008297:Male; D009281:Naphthalenes / Q000378:metabolism*; D010150:Paint / Q000009:adverse effects; D051381:Rats; D011916:Rats, Inbred F344; D012997:Solvents / Q000009:adverse effects; D013764:Tetrahydronaphthalenes / Q000009:adverse effects / Q000378:metabolism* / Q000633:toxicity
chemical_list: D009281:Naphthalenes; D012997:Solvents; D013764:Tetrahydronaphthalenes