title: Tyrosine hydroxylase maps to the short arm of chromosome 11 proximal to the insulin and HRAS1 loci.
abstract: Tyrosine hydroxylase (TH) is the rate-limiting enzyme for catecholamine biosynthesis and a candidate gene for manic-depressive illness. The TH locus was typed for a BglII RFLP using a cDNA clone Ty7 in four large kindreds. Pairwise analyses and multipoint analyses were carried out to map the TH locus more precisely in the region of the linked markers: D11S12, INS, and HRAS1 on 11p. Results confirm the close linkage between TH with these previously mapped markers and support a most likely ordering which places TH on the side of INS where the centromere lies.
authors.affiliation: Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510.
authors.forename: F
authors.initials: F
authors.lastname: Xue
authors.forename: J R
authors.initials: JR
authors.lastname: Kidd
authors.forename: A J
authors.initials: AJ
authors.lastname: Pakstis
authors.forename: C M
authors.initials: CM
authors.lastname: Castiglione
authors.forename: J
authors.initials: J
authors.lastname: Mallet
authors.forename: K K
authors.initials: KK
authors.lastname: Kidd
mesh_terms: D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D004262:DNA Restriction Enzymes; D005260:Female; D005796:Genes; D011905:Genes, ras; D008040:Genetic Linkage; D006801:Humans; D007328:Insulin / Q000235:genetics*; D008126:Lod Score; D008297:Male; D010375:Pedigree; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
chemical_list: D007328:Insulin; D014446:Tyrosine 3-Monooxygenase; D004262:DNA Restriction Enzymes