Ceruloplasmin can substitute for rabbit serum in stimulating the growth of Treponema denticola.
The growth of Treponema denticola in a complex medium was stimulated by human ceruloplasmin and, to a lesser extent, albumin, alpha-1-antitrypsin, alpha-1-acid glycoprotein, and alpha-2-macroglobulin. Human ceruloplasmin could stimulate growth of T. denticola as well as or better than 5% rabbit serum, with a dose-response relationship of between 1 and 5 mg of ceruloplasmin per ml of culture medium. These results suggest that ceruloplasmin could substitute for rabbit serum in stimulating the growth of T. denticola.
Suzuki
M
M
Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor 48109-1078.
Loesche
W J
WJ
D000818:Animals; D001790:Blood Physiological Phenomena; D002570:Ceruloplasmin / Q000494:pharmacology*; D003470:Culture Media; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D011817:Rabbits; D014208:Treponema / Q000187:drug effects / Q000254:growth & development*
D003470:Culture Media; D006133:Growth Substances; D002570:Ceruloplasmin