title: Effects of an extract of feverfew on endothelial cell integrity and on cAMP in rabbit perfused aorta.
abstract: Extracts of feverfew inhibit platelet aggregation and secretion of granular contents from platelets and other cells. They also modify the interaction of platelets with collagen substrates: feverfew extracts inhibit both platelet spreading and formation of thrombus-like platelet aggregates on the collagen surface. We have now investigated the effect of an extract of feverfew on the vessel wall using rabbit aortas that were perfused with a physiological salt solution in-situ. Addition of feverfew extract to the perfusion medium protected the endothelial cell monolayer from perfusion-induced injury and led to a reversible increase in the cAMP content of aorta segments. The results indicate that feverfew may have a vasoprotective effect in addition to its effects on platelets.
authors.affiliation: Institute of Experimental Cardiology, USSR Cardiology Research Centre, Moscow.
authors.forename: T A
authors.initials: TA
authors.lastname: Voyno-Yasenetskaya
authors.forename: W
authors.initials: W
authors.lastname: Loesche
authors.forename: W A
authors.initials: WA
authors.lastname: Groenewegen
authors.forename: S
authors.initials: S
authors.lastname: Heptinstall
authors.forename: V S
authors.initials: VS
authors.lastname: Repin
authors.forename: U
authors.initials: U
authors.lastname: Till
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology* / Q000187:drug effects; D066298:In Vitro Techniques; D007700:Kinetics; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011817:Rabbits; D012016:Reference Values
chemical_list: D010936:Plant Extracts; D000242:Cyclic AMP