Evidence for a physiological role for CCK in the regulation of food intake in mice.
The effects of L-364,718, a cholecystokinin receptor antagonist, on cholecystokinin octapeptide-induced inhibition of food, and its effect on food intake when given alone, were studied in mice using several different feeding paradigms. In all studies, L-364,718 (100 micrograms/kg, 1.0 mg/kg) reversed the ability of cholecystokinin octapeptide to decrease food intake. L-364,718 enhanced food consumption compared with controls in nonfasted mice (100 microgram/kg) and in prefed mice (50, 100, 250 micrograms/kg). The number of reinforcements, using a lever press, was also enhanced by L-364,718 (100 micrograms/kg) compared with control. In other paradigms, L-364,718 failed to enhance food intake. These results are compatible with the suggestion that cholecystokinin may play a physiological role in the regulation of food intake.
Silver
A J
AJ
Geriatric Research, Education, and Clinical Center, Sepulveda Veterans Administration Medical Center 91343.
Flood
J F
JF
Song
A M
AM
Morley
J E
JE
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors* / Q000502:physiology; D020109:Devazepide; D005215:Fasting; D005247:Feeding Behavior / Q000187:drug effects*; D006706:Homeostasis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D012016:Reference Values
D001570:Benzodiazepinones; D002766:Cholecystokinin; D020109:Devazepide