Lack of interaction between nizatidine and warfarin during chronic administration.
Nizatidine is a new antagonist of H2 receptors. The nizatidine warfarin interaction was investigated in healthy volunteers during chronic warfarin (mean warfarin dose: 5 +/- 0.9 mg/d) and nizatidine (300 mg/d) administration. Nizatidine coadministration did not increase the prothrombin time, kaolin-cephalin clotting time, and did not modify the activity of clotting factors II, VII, IX, X. Nizatidine did not influence the steady-state plasma warfarin concentration.
Cournot
A
A
Département de Pharmacologie Clinique, Hôpital Pitié-Salpétrière, Paris, France.
Berlin
I
I
Sallord
J C
JC
Singlas
E
E
D000328:Adult; D001779:Blood Coagulation Factors / Q000378:metabolism; D004347:Drug Interactions; D006635:Histamine H2 Antagonists / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D016567:Nizatidine; D011516:Prothrombin / Q000378:metabolism; D013844:Thiazoles / Q000493:pharmacokinetics / Q000494:pharmacology*; D014859:Warfarin / Q000493:pharmacokinetics / Q000494:pharmacology*
D001779:Blood Coagulation Factors; D006635:Histamine H2 Antagonists; D013844:Thiazoles; D014859:Warfarin; D011516:Prothrombin; D016567:Nizatidine