5-(1-piperazinyl)-1H-1,2,4-triazol-3-amines as antihypertensive agents.
A series of 5-(1-piperazinyl)-1H-1,2,4-triazol-3-amines was synthesized and screened for antihypertensive and diuretic activity in spontaneously hypertensive rats (SHR). One compound, 5-[4-[(3-chlorophenyl)methyl]-1-piperazinyl]-1H-1,2,4-triazol-3-am ine (8), was selected to define the mechanism of its antihypertensive activity. Studies in SHR suggest ganglionic blocking activity. Short-lived antihypertensive activity was observed in conscious renal hypertensive dogs.
Meyer
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American Cyanamid Company, Medical Research Division, Lederle Laboratories, Pearl River, New York 10965.
Tomcufcik
A S
AS
Chan
P S
PS
Haug
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M
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004232:Diuretics / Q000138:chemical synthesis; D004285:Dogs; D006973:Hypertension / Q000503:physiopathology; D006978:Hypertension, Renovascular / Q000503:physiopathology; D008297:Male; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000959:Antihypertensive Agents; D004232:Diuretics; D010879:Piperazines; D014230:Triazoles