Relaxant and beta 2-adrenoceptor blocking activities of labetalol, dilevalol, amosulalol and KF-4317 on the rat isolated aorta.
The KCl-contracted rat aorta is relaxed by labetalol, dilevalol, amosulalol and KF-4317. These relaxations are not reversed by ICI 118,551 at 10(-6) M and, therefore, are not due to beta-adrenoceptor agonism. At 10(-7) M, labetalol, dilevalol, amosulalol and KF-4317 were beta 2-adrenoceptor antagonists as they inhibited the relaxant responses of rat aorta to procaterol.
Doggrell
S A
SA
Department of Pharmacology, School of Medicine, University of Auckland, Private Bag, New Zealand.
D000318:Adrenergic beta-Agonists / Q000037:antagonists & inhibitors; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D044482:Benzeneacetamides; D004983:Ethanolamines / Q000037:antagonists & inhibitors / Q000494:pharmacology; D066298:In Vitro Techniques; D007741:Labetalol / Q000494:pharmacology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D017265:Procaterol; D011412:Propanolamines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D000096926:Benzenesulfonamides
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D044482:Benzeneacetamides; D004983:Ethanolamines; D007741:Labetalol; D017265:Procaterol; D011412:Propanolamines; C039100:KF 4317; C032473:amosulalol; D000096926:Benzenesulfonamides