Mechanism of SOS-induced targeted and untargeted mutagenesis in E. coli.
This paper retraces the evolution of hypotheses concerning mechanisms of SOS induced mutagenesis. Moreover, it reports some recent data which support a new model for the mechanism of targeted and untargeted mutagenesis in E. coli. In summary, the SOS mutator effect, which is responsible for untargeted mutagenesis and perhaps for the misincorporation step in targeted mutagenesis, is believed to involve a fidelity function associated with DNA polymerase III and does not require the umuC gene product. umuC and umuD gene products are probably required specifically for elongation of DNA synthesis past blocking lesions, i.e. to allow mutagenic replication of damaged DNA.
Maenhaut-Michel
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D010582:Bacteriophage lambda / Q000235:genetics; D004258:DNA Polymerase III / Q000502:physiology; D004260:DNA Repair; D004261:DNA Replication / Q000187:drug effects; D004269:DNA, Bacterial / Q000235:genetics / Q000528:radiation effects; D004279:DNA, Viral / Q000235:genetics / Q000528:radiation effects; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D005798:Genes, Bacterial; D009153:Mutagens / Q000494:pharmacology; D009154:Mutation; D010777:Photochemistry; D011740:Pyrimidine Dimers; D011938:Rec A Recombinases / Q000502:physiology; D014466:Ultraviolet Rays
D004269:DNA, Bacterial; D004279:DNA, Viral; D009153:Mutagens; D011740:Pyrimidine Dimers; D011938:Rec A Recombinases; D004258:DNA Polymerase III