Counteraction by combined treatment with high dose of oestrogen and somatostatin of mammary growth suppression in mice.
The interaction between somatostatin (SMS) and high doses of oestrogen on mammary gland growth was examined in C3H/He virgin mice. Mammary gland growth was significantly suppressed by the subcutaneous implantation of pellets of oestradiol benzoate diluted to 1/1000 or 1/500 or by injection twice daily of 50ng SMS 201-995 between 25 and 55 days of age. However, the mammary gland growth of mice receiving SMS and oestrogen in combination was markedly stimulated compared to that of mice given the respective agents. These results indicate that the inhibitory effects of somatostatin and oestrogen on mammary growth were apparently counteracted by the treatment in combination.
Nagasawa
H
H
Experimental Animal Research Laboratory, Meiji University, Kanagawa, Japan.
Koshimizu
U
U
Sakagami
N
N
D000375:Aging; D000818:Animals; D004343:Drug Implants; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000254:growth & development*; D051379:Mice; D008809:Mice, Inbred C3H; D015282:Octreotide / Q000494:pharmacology*; D009929:Organ Size; D009928:Organ Specificity; D013004:Somatostatin / Q000494:pharmacology*
D004343:Drug Implants; D004958:Estradiol; D013004:Somatostatin; D015282:Octreotide