Chronic cavitary histoplasmosis. Failure of oral treatment with ketoconazole.
Ketoconazole appears to be a safe drug in the treatment of chronic cavitary histoplasmosis. Primary failure and relapse have been described, requiring amphotericin B, even after long therapy with ketoconazole. Four typical cases are presented. We caution about such potential failures and stress the importance of close observation of patients begun on therapy with ketoconazole for chronic cavitary histoplasmosis.
Quinones
C A
CA
Division of General Internal Medicine, University of Texas Health Science Center, Houston.
Reuben
A G
AG
Hamill
R J
RJ
Musher
D M
DM
Gorin
A B
AB
Sarosi
G A
GA
D000284:Administration, Oral; D000666:Amphotericin B / Q000627:therapeutic use; D006660:Histoplasmosis / Q000188:drug therapy*; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013997:Time Factors
D000666:Amphotericin B; D007654:Ketoconazole