Cardiopulmonary responses to Pseudomonas septicemia in swine: an improved model of the adult respiratory distress syndrome.
Bacteremia with resultant damage to multiple organ systems remains a serious problem in intensive care of human patients. We have developed a clinically relevant swine model of sepsis-induced adult respiratory distress syndrome (ARDS). Twenty-three animals were given various doses of Pseudomonas aeruginosa intravenously. Low cardiac output septic shock was prevented with massive fluid infusion. It was found that a dose of 1.0 X 10(7) colony forming units per 20 kg/min for 2 hours reliably produced respiratory failure in a setting of hyperdynamic sepsis which meets the diagnostic criteria of human ARDS.
Mustard
R A
RA
Department of Surgery, Wellesley Hospital, Toronto, Ontario, Canada.
Fisher
J
J
Hayman
S
S
Matlow
A
A
Mullen
J B
JB
Odumeru
J
J
Roomi
M W
MW
Schouten
B D
BD
Swanson
H T
HT
D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D004195:Disease Models, Animal; D005260:Female; D005440:Fluid Therapy; D006339:Heart Rate; D008297:Male; D010100:Oxygen / Q000097:blood; D011552:Pseudomonas Infections / Q000150:complications / Q000503:physiopathology*; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000503:physiopathology*; D018805:Sepsis / Q000150:complications / Q000503:physiopathology*; D012772:Shock, Septic / Q000517:prevention & control; D013552:Swine
D010100:Oxygen