title: [Side effects in chemoradiotherapy of bladder cancer].
abstract: Chemoradiation treatment was given to 60 patients with locally-advanced cancers of the urinary bladder and their recurrences. Split-course radiotherapy was carried out using a rotation technique at 3-4 week intervals. Total focal dose for two courses was 65-70 Gy. Combined therapy used cyclophosphamide, dactinomycin and cisplatin. Chemotherapy was given immediately after each course of irradiation. Concomitant cardiovascular pathology was registered in 46.6% of patients and renal function derangement--in 36.6%. However, all the patients, except three, received treatment matched by symptomatic therapy. Myelosuppression was among major side effects. Response was assessed in 47 cases (75%). The immediate effect of combined treatment was observed in 57.4%.
authors.forename: V I
authors.initials: VI
authors.lastname: Shipilov
authors.forename: V A
authors.initials: VA
authors.lastname: Gorbunova
authors.forename: A I
authors.initials: AI
authors.lastname: Barkanov
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000628:therapy; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000628:therapy; D002295:Carcinoma, Transitional Cell / Q000150:complications / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D001749:Urinary Bladder Neoplasms / Q000150:complications* / Q000628:therapy
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin
vernacular_title: Pobochnye éffekty pri khimioluchevoĭ terapii raka mochevogo puzyria.