Adverse reactions to sulphasalazine and 5-amino salicylic acid in the same patient.
We report a patient who developed sulphasalazine-related hepatitis with a subsequent adverse reaction to rectal 5-amino salicylic acid, in the form of pain and fever without associated liver dysfunction, suggesting reactions to both components of sulphasalazine. Included is a review of the literature. Caution should be observed when prescribing 5-amino salicylic acid to sulphasalazine-intolerant patients.
Burke
D A
DA
Gastroenterology Unit, General Infirmary, Leeds, UK.
Manning
A P
AP
Williamson
J M
JM
Axon
A T
AT
D000328:Adult; D000636:Aminosalicylic Acids / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D019804:Mesalamine; D012460:Sulfasalazine / Q000009:adverse effects*
D000636:Aminosalicylic Acids; D012460:Sulfasalazine; D019804:Mesalamine