title: A randomized comparison of a rapid versus prolonged (24 hr) infusion of cisplatin in therapy of squamous cell carcinoma of the uterine cervix: a Gynecologic Oncology Group study.
abstract: In this study, 331 patients with advanced or recurrent squamous cell carcinoma of the cervix no longer amenable to control with surgery or radiotherapy were randomized to receive cisplatin 50 mg/m2 as either a continuous infusion over 24 hr or a more rapid infusion at a rate of 1 mg/min. Antiemetic therapy was standardized for the initial course of both regimens as metoclopramide 60 mg at the time of and at 3 and 6 hours after initiation of cisplatin. The overall frequency of objective regression of disease was 18%; the response rate in each regimen was essentially identical. The continuous infusion regimen was associated with a significantly greater percentage of patients who experienced no nausea and vomiting (34% versus 18%, P = 0.002). Other adverse effects included nephrotoxicity, peripheral neuropathy, myelosuppression, and ototoxicity. Both the frequency and severity of these were essentially the same for each regimen.
authors.affiliation: Department of Medicine, University of Mississippi School of Medicine, Jackson.
authors.forename: J T
authors.initials: JT
authors.lastname: Thigpen
authors.forename: J A
authors.initials: JA
authors.lastname: Blessing
authors.forename: P J
authors.initials: PJ
authors.lastname: DiSaia
authors.forename: W C
authors.initials: WC
authors.lastname: Fowler
authors.forename: K D
authors.initials: KD
authors.lastname: Hatch
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D011897:Random Allocation; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
chemical_list: D002945:Cisplatin