title: Hepatic metastases: rat models for imaging research.
abstract: Improved rat liver tumor models with solitary or multiple metastatic tumors were developed for radiological imaging research. Unlike previous studies which employed trocar inoculation of tumor fragments, an enzymatically disaggregated cell suspension of mammary cancer was injected by fine needle either directly into the liver to produce solitary cancer nodules, or indirectly via the spleen or mesenteric vein to produce multiple liver metastases. Tumor size was proportional to the time elapsed after implantation. The operative mortality of direct liver, splenic parenchymal, and mesenteric inoculations were 8%, 4%, and 27%, respectively. MR tissue characteristics, image contrast, and pharmaceutical enhancement of these tumors closely resembles human hepatic metastases. The availability of reproducible, inexpensive animal models of metastatic cancer allows efficient evaluation of new liver imaging techniques.
authors.affiliation: Department of Radiology, National Taiwan University Hospital, Taipei, Republic of China.
authors.forename: M C
authors.initials: MC
authors.lastname: Chen
authors.forename: Y M
authors.initials: YM
authors.lastname: Tsang
authors.forename: D D
authors.initials: DD
authors.lastname: Stark
authors.forename: R
authors.initials: R
authors.lastname: Weissleder
authors.forename: S
authors.initials: S
authors.lastname: Saini
authors.forename: J
authors.initials: J
authors.lastname: Brandhorst
authors.forename: D L
authors.initials: DL
authors.lastname: White
authors.forename: B L
authors.initials: BL
authors.lastname: Engelstad
authors.forename: J T
authors.initials: JT
authors.lastname: Ferrucci
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis; D000818:Animals; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008325:Mammary Neoplasms, Experimental; D009368:Neoplasm Transplantation; D051381:Rats; D011916:Rats, Inbred F344