Chemotherapy of experimental (murine) Clostridium perfringens type A gas gangrene.
Five antimicrobial drugs (ciprofloxacin, clindamycin, imipenem, penicillin G, and rifampin) were examined for therapeutic efficacy in a murine model gas gangrene due to Clostridium perfringens type A, following infection with large bacterial inocula. Imipenem was effective against all 6 strains of C. perfringens; conversely, penicillin G failed against these 6 strains. Ciprofloxacin, clindamycin, and rifampin occupied intermediate positions.
Traub
W H
WH
Institut für Medizinische Mikrobiologie und Hygiene, Universität des Saarlandes, Homburg, BRD.
D000818:Animals; D002939:Ciprofloxacin / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D003016:Clostridium perfringens / Q000187:drug effects; D004195:Disease Models, Animal; D005738:Gas Gangrene / Q000188:drug therapy*; D015378:Imipenem / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology
D002981:Clindamycin; D002939:Ciprofloxacin; D015378:Imipenem; D010400:Penicillin G; D012293:Rifampin