title: Familial vestibulocerebellar dysfunction: a new syndrome?
abstract: Three members of a single family with the symptom of "motion sickness" showed rebound nystagmus, saccadic pursuit eye movements, defective optokinetic slow phase velocity and lack of fixation suppression of vestibularly induced nystagmus. One of them showed vestibular hyperreactivity and a gradual build-up of the optokinetic response. In absence of other abnormalities, these findings can be localized to the vestibulocerebellum (flocculo-nodular lobe).
authors.affiliation: Department of Otolaryngology, Academic Hospital Nijmegen, The Netherlands.
authors.forename: E J
authors.initials: EJ
authors.lastname: Theunissen
authors.forename: P L
authors.initials: PL
authors.lastname: Huygen
authors.forename: W I
authors.initials: WI
authors.lastname: Verhagen
mesh_terms: D000328:Adult; D002526:Cerebellar Diseases / Q000235:genetics* / Q000503:physiopathology; D002648:Child; D005260:Female; D006801:Humans; D009759:Nystagmus, Pathologic / Q000209:etiology / Q000503:physiopathology; D012027:Reflex, Vestibulo-Ocular; D013577:Syndrome; D014725:Vestibular Nerve / Q000503:physiopathology*