[Antiallergic effects of mequitazine. 2. In vivo experiments].
Antiallergic effects of mequitazine were investigated in vivo and compared with those of ketotifen and disodium cromoglycate (DSCG). The results obtained were as follows: 1) Mequitazine in doses of 2 and 5 mg/kg given, p.o., 1 hr prior to antigen challenge inhibited dose-dependently the 48-hr passive cutaneous anaphylaxis in rats. Five mg/kg of mequitazine showed almost the same extent of inhibitory activity as that of 1 mg/kg of ketotifen. An i.v. administration of 1 mg/kg DSCG 1 min before antigen challenge also showed a marked inhibition. 2) The experimental asthma induced by challenge with an i.v. injection of antigen in passively sensitized guinea pigs was fairly inhibited by the pretreatment with 5 mg/kg of mequitazine administered p.o., although 2 mg/kg of this drug showed only a slight inhibition. 3) The experimental asthma induced by aerosolized antigen was also fairly inhibited by the pretreatment with 5 mg/kg of mequitazine given p.o.
Kohno
S
S
Department of Pharmacology, Kyoto Pharmaceutical University, Japan.
Yamamura
H
H
Ohata
K
K
Togawa
M
M
Nagai
H
H
Koda
A
A
Yanagihara
Y
Y
Shida
T
T
Yatsuzuka
A
A
Yoshida
Y
Y
D000284:Administration, Oral; D000818:Animals; D001249:Asthma / Q000188:drug therapy; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007275:Injections, Intravenous; D008297:Male; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D010640:Phenothiazines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D006634:Histamine H1 Antagonists; D010640:Phenothiazines; D004205:Cromolyn Sodium; C006069:mequitazine