title: Brain cholecystokinin depletion in rats with acute liver failure.
abstract: A decrease of both hypothalamic and cortical CCK occurred in the brain of rats killed 8 hours after hepatic artery ligation following portocaval anastomosis. Brain CCK depletion was not reproduced by exogenously provoked hyperammonemia nor by insulin-induced hypoglycemia, thus suggesting a central mechanism for the derangement of the CCKergic system in the course of acute liver failure.
authors.affiliation: Instituti di Medicina Interna e di Clinica Chirurgica I, Ospedale Policlinico-Università di Milano, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Bonato
authors.forename: A
authors.initials: A
authors.lastname: Malesci
authors.forename: R
authors.initials: R
authors.lastname: Rosati
authors.forename: F
authors.initials: F
authors.lastname: Vignati
authors.forename: M
authors.initials: M
authors.lastname: Montorsi
authors.forename: M
authors.initials: M
authors.lastname: Bersani
authors.forename: R
authors.initials: R
authors.lastname: Abbiati
authors.forename: F
authors.initials: F
authors.lastname: Salerno
mesh_terms: D000641:Ammonia / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D002766:Cholecystokinin / Q000378:metabolism*; D004195:Disease Models, Animal; D007031:Hypothalamus / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001786:Blood Glucose; D000641:Ammonia; D002766:Cholecystokinin