title: New approach in bioavailability study of two formulations of ethyl loflazepate.
abstract: The disposition of ethyl loflazepate (Victan) was studied on 12 healthy male volunteers after administration of the two oral formulations of the drug: one 4-mg tablet and two 2-mg tablets according to an open crossover single dose comparison. A model-independent analysis and a model-dependent approach were used to treat experimental data. Appropriate statistical tests (ANOVA, Wilcoxon test, Westlake test for model-independent parameters; principal components analysis, Hotelling T2 test for model-dependent parameters) demonstrated the bioequivalence of the two formulations.
authors.affiliation: INSERM U 278, Faculty of Pharmacy, Marseille, France.
authors.forename: B B
authors.initials: BB
authors.lastname: Ba
authors.forename: A
authors.initials: A
authors.lastname: Iliadis
authors.forename: A
authors.initials: A
authors.lastname: Durand
authors.forename: Y
authors.initials: Y
authors.lastname: Berger
authors.forename: J P
authors.initials: JP
authors.lastname: Cano
mesh_terms: D000284:Administration, Oral; D000328:Adult; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D006801:Humans; D008297:Male; D008433:Mathematics; D008954:Models, Biological
chemical_list: D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C029617:ethyl loflazepate