Childhood transient erythroblastopenia complicated by thrombocytopenia and neutropenia.
We report on 4 children with transient erythroblastopenia complicated by thrombocytopenia and/or neutropenia. Bone marrow examination revealed severe erythroid hypoplasia with normal granulopoiesis and thrombopoiesis. Human parvovirus B19 infection was confirmed serologically in 2 children. An in vitro study using autologous bone marrow cells after recovery demonstrated IgG-mediated inhibition of erythropoiesis in 4 children. Additionally, antibodies directed against platelets and neutrophils were detected. These findings suggest that the IgG-mediated mechanism may be pathogenetic for the transient pancytopenia of these children.
Hanada
T
T
Department of Pediatrics, University of Tsukuba, Ibaraki, Japan.
Koike
K
K
Hirano
C
C
Takeya
T
T
Suzuki
T
T
Matsunaga
Y
Y
Takita
H
H
D000380:Agranulocytosis / Q000150:complications*; D000740:Anemia / Q000150:complications* / Q000276:immunology; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004900:Erythroblasts / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D007223:Infant; D008297:Male; D009503:Neutropenia / Q000150:complications*; D013921:Thrombocytopenia / Q000150:complications*
D007074:Immunoglobulin G