Combination of disopyramide and propranolol in hypertrophic cardiomyopathy.
Fifteen patients were studied by echocardiography, apexcardiogram and carotid pulse tracings in four ways: basally; on propranolol 40 mg, three times daily; on disopyramide 200 mg single dose, three days after propranolol discontinuation; and on both drugs. The following data were measured: systolic anterior mitral motion slope, systolic anterior mitral distance from the septum, outflow tract diameter, the A wave to the total apexcardiographic excursion ratio, carotid pulse contour and left ventricular ejection time index. Propranolol did not produce any significant changes while disopyramide was much more effective in changing the data in a direction suggesting diminution of left ventricular outflow gradient. The combination of propranolol and disopyramide had the greatest influence. Fourteen patients received the two drugs for 12.3 +/- 4.3 months with improvement of NYHA class.
Cokkinos
D V
DV
Cardiology Department, Tzanio State Hospital, Piraeus, Greece.
Salpeas
D
D
Ioannou
N E
NE
Christoulas
S
S
D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis / Q000188:drug therapy*; D004206:Disopyramide / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004452:Echocardiography; D005260:Female; D006801:Humans; D007702:Kinetocardiography; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use*; D011446:Prospective Studies; D011674:Pulse
D011433:Propranolol; D004206:Disopyramide