Effect of clindamycin on factor-VII activity in healthy cats.
Four healthy cats were given clindamycin orally in daily doses of 25 or 50 mg/kg of body weight for 6 weeks. Significant change in Factor-VII activity was not found, compared with pretreatment values. In 2 cats tested, toxin produced by Clostridium difficile was not detected in fecal samples obtained before treatment and at 6 weeks after treatment, suggesting that intestinal overgrowth by C difficile did not develop. Results of the study seemed to indicate that orally administered clindamycin does not measurably reduce synthesis of vitamin K-dependent clotting factors in healthy cats.
Jacobs
G
G
Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
Lappin
M
M
Marks
A
A
Greene
C E
CE
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D002371:Cat Diseases / Q000139:chemically induced; D002415:Cats / Q000097:blood*; D002981:Clindamycin / Q000633:toxicity*; D005167:Factor VII / Q000378:metabolism*; D005260:Female; D008297:Male; D014839:Vomiting / Q000139:chemically induced / Q000662:veterinary
D002981:Clindamycin; D005167:Factor VII