Dose-dependent memory impairment in Parkinson's disease.
Variation in plasma dopamine level between the time of original learning and subsequent memory retrieval causes a state-dependent memory impairment in Parkinson's disease. The occurrence of this phenomenon is not related to either progression of disease or duration of therapy, but is more likely to occur with high-dosage levels of levodopa-carbidopa.
Huber
S J
SJ
Ohio State University College of Medicine, Department of Neurology, Columbus 43210.
Shulman
H G
HG
Paulson
G W
GW
Shuttleworth
E C
EC
D002230:Carbidopa / Q000008:administration & dosage / Q000009:adverse effects*; D004298:Dopamine / Q000097:blood; D004338:Drug Combinations / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects*; D008569:Memory Disorders / Q000097:blood / Q000139:chemically induced*; D010300:Parkinson Disease / Q000097:blood / Q000188:drug therapy / Q000523:psychology*
D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa; D004298:Dopamine