title: Severe intra-uterine growth retardation: obstetrical management and follow up studies in children born between 1970 and 1985.
abstract: Peri- and postnatal data of 263 children with severe intra-uterine growth retardation (IUGR) born between 1970-75 (n = 145) and between 1976-85 (n = 118) are presented. The incidence of premature delivery in IUGR patients rose from 15% (1970-75) to 34% (1976-85). The rate of perinatal asphyxia in premature children with IUGR decreased from 64% during 1970-75 to 45% during 1976-85. Perinatal mortality in preterm SFD babies was higher in 1976-85 (20%) than in 1970-75 (14%), due to an 8-fold higher incidence of very low birth weight (less than or equal to 1000 g) SFD babies. Without this high-risk group perinatal mortality ranged between 2 and 3% in both groups. The incidence of deliveries by Cesarean section increased from 19 to 45% while vaginal deliveries decreased from 73 to 52% during 1976-85 compared with the 1970-75 age group. Follow up studies were carried out in 63 patients (1970-75) and in 41 patients (1976-85). Deficits of body height and weight persisted in one third of the patients, being severe in 10-20%. Infantile developmental milestones were retarded in 22-32%. Neurologic sequelae mostly of a mild degree were seen in 29% (1970-75) and 37% (1976-85). Psychologic testing showed abnormalities in 38% of the older age group, using the Göttinger Formreproduktionstest and in 21% of the younger age group, where the Denver Developmental Screening Test was performed. EEG investigations demonstrated unspecific abnormalities of a mild to moderate degree in one third of the patients.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: University Children's Hospital Cologne, F.R.G.
authors.forename: U
authors.initials: U
authors.lastname: Schauseil-Zipf
authors.forename: W
authors.initials: W
authors.lastname: Hamm
authors.forename: B
authors.initials: B
authors.lastname: Stenzel
authors.forename: A
authors.initials: A
authors.lastname: Bolte
authors.forename: E
authors.initials: E
authors.lastname: Gladtke
mesh_terms: D001827:Body Height; D001835:Body Weight; D002585:Cesarean Section; D002657:Child Development; D036861:Delivery, Obstetric; D005260:Female; D005317:Fetal Growth Retardation; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy