title: Cognitive impairment in late-life depression: clinical correlates and treatment implications.
abstract: Elderly depressed inpatients with high vs. low scores on a quantitative mental status examination (the Mini-Mental State (MMS)) were compared with regard to demographic and clinical characteristics, treatment and short-term response, and functional status at 2-year follow-up. Low-MMS patients were less well educated and more likely to be delusional, anxious, and globally impaired than high-MMS patients. The two groups responded equally well to treatment, but the low-MMS group required a lengthier hospital stay and greater use of neuroleptic medications. The two groups also had similar long-term outcomes, although greater attrition was observed among cognitively impaired subjects.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000523:psychology* / Q000628:therapy; D003866:Depressive Disorder / Q000523:psychology* / Q000628:therapy; D004565:Electroconvulsive Therapy; D005500:Follow-Up Studies; D006801:Humans; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D011619:Psychotropic Drugs / Q000627:therapeutic use
chemical_list: D011619:Psychotropic Drugs