[Acetylsalicylic acid and pyrazole allergy or pseudo-allergy?].
In a multicentric study by the European Study Group of Drug Allergy, 69 patients suffering from immediate type reaction after the intake of non-steroidal antiphlogistica were examined with regard to allergy or pseudo-allergy. Apart from the scratch test on the original substance, we performed cutaneous tests with salicyloyl and pyrazol conjugates, and determined IgE and IgG by means of a modified RAST method. There were 3 groups to be distinguished: (1) "intolerance" reaction of the aspirin type as a pseudo-allergic reaction (15 cases); (2) true IgE-mediated allergy (16 cases); (3) pyrazol "idiosyncrasy" (33 cases). 5 patients showed a combination of the three pathomechanisms.
D001241:Aspirin / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000209:etiology; D007428:Intradermal Tests; D011720:Pyrazoles / Q000009:adverse effects*; D013329:Structure-Activity Relationship
D011720:Pyrazoles; D001241:Aspirin
Acetylsalicylsäure- und Pyrazol-Allergie oder Pseudo-Allergie?