Renal effects of synthetic rat-atrial natriuretic peptide in nephron-reduced rats with nephrotoxic nephritis.
Following nephron reduction by means of five--sixths nephrectomy (Nx), nephritis was induced in rats by injection of nephrotoxic serum (NTS). A continuous intravenous infusion of synthetic rat--atrial natriuretic peptide (r-ANP) at 2.5 micrograms/min for produced remarkable diuresis and natriuresis in these rats. Furthermore, inulin clearance, para-amino-hippuric acid clearance and filtration fraction increased in spite of the reduction of mean arterial pressure during the infusion of r-ANP. It was therefore evident that diuresis and natriuresis were mediated by a direct action of r-ANP in the kidney. We observed that r-ANP was a diuretic, natriuretic and hypotensive agent but at a higher dosage in Nx rats with NTN.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007106:Immune Sera; D007668:Kidney / Q000187:drug effects / Q000276:immunology / Q000503:physiopathology; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D009392:Nephrectomy; D009393:Nephritis / Q000276:immunology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains
D007106:Immune Sera; D009320:Atrial Natriuretic Factor