title: Plasma concentrations of 3-keto-desogestrel after oral administration of desogestrel and intravenous administration of 3-keto-desogestrel.
abstract: The plasma concentrations of 3-keto-desogestrel have been measured by radioimmunoassay in a crossover study in nine healthy female volunteers given oral desogestrel (150 micrograms) and ethinyloestradiol (30 micrograms) and intravenous (i.v.) 3-keto-desogestrel (150 micrograms) and ethinyloestradiol (30 micrograms). Bioavailability ranged between 40.0 and 113% with a mean value ( +/- SD) of 76.1 +/- 22.5%. Only 3 subjects had a bioavailability of less than 70%. There was no significant difference in the elimination half life of 3-keto-desogestrel which was 12.6 +/- 4.1h following i.v. administration and 11.9 +/- 4.1h after oral administration of desogestrel.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D017135:Desogestrel; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000378:metabolism; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D009652:Norpregnenes / Q000008:administration & dosage* / Q000097:blood* / Q000378:metabolism
chemical_list: D009652:Norpregnenes; C044815:etonogestrel; D004997:Ethinyl Estradiol; D017135:Desogestrel