Thymoxamine: a miotic for intraocular use.
Thymoxamine hydrochloride can be used intraocularly to reverse phenylephrine or epinephrine mydriasis during intraocular surgery (0.2-0.5 ml of 0.01% or 0.02% solutions proved to be effective). No endothelial damage was found up to a dose of 1 ml of 0.02% thymoxamine in animal experiments using a physiologically buffered solution. Since stability is low in the buffered state, the final concentration has to be prepared at the time of surgery using a 0.5% solution and a phosphate buffer. Intracameral thymoxamine is a potent miotic during operations and can be helpful in extracapsular cataract surgery, keratoplasty, and repair of perforating injuries.
D000818:Animals; D002415:Cats; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005128:Eye Diseases / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007432:Intraoperative Period; D008916:Miotics / Q000627:therapeutic use*; D013948:Moxisylyte / Q000627:therapeutic use*
D008916:Miotics; D013948:Moxisylyte