title: Modulation of steroid hormone receptors in the brain--inhibitory effect of fatty acids on the binding between cytosol progestin receptors in the rat cortex and R5020.
abstract: The specific binding of R5020 to the 7S cortical progestin receptors was markedly inhibited by unsaturated long chain fatty acids, such as oleic acid, arachidonic acid, and docosahexaenoic acid. The inhibitory effect of docosahexaenoic acid was dose-dependent in the range of 1.5 X 10(-6) M to 1.5 X 10(-4) M.
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D003600:Cytosol / Q000187:drug effects*; D004281:Docosahexaenoic Acids; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D009649:Norpregnadienes / Q000378:metabolism*; D011397:Promegestone / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011980:Receptors, Progesterone / Q000187:drug effects*
chemical_list: D005231:Fatty Acids, Unsaturated; D009649:Norpregnadienes; D011980:Receptors, Progesterone; D004281:Docosahexaenoic Acids; D011397:Promegestone