Novel leukotriene antagonists: structure activity of analogs of LTD4. Replacement of the 1-carboxylic group by a methyl group ("methyl principle") results in leukotriene antagonists and phospholipase inhibitors.
D000818:Animals; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D010740:Phospholipases / Q000037:antagonists & inhibitors; D013189:SRS-A / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D013329:Structure-Activity Relationship
C058160:CGP 34064A; D013189:SRS-A; D010740:Phospholipases