Lymphocyte subpopulations in uveitis.
We have used a fluorescence-activated cell sorter to study the lymphocyte subpopulations in the intraocular fluids and peripheral blood of 27 patients with uveitis. T lymphocytes predominated in intraocular fluids. A wide variation in the ratio of Leu 3a-positive (helper) cells to Leu 2a-positive (suppressor) cells was found. No correlation was seen between the specific lymphocyte subpopulations and the clinical uveitis activity or steroid treatment. A statistically significant correlation was found between T-cell subsets present in aqueous humor and peripheral blood. Many lymphocytes seem to be present in intraocular fluids secondary to a breakdown of the blood-ocular barrier.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis; D001082:Aqueous Humor / Q000166:cytology; D001402:B-Lymphocytes / Q000145:classification; D001773:Blood Cells / Q000145:classification; D002469:Cell Separation; D005434:Flow Cytometry; D006801:Humans; D008214:Lymphocytes / Q000145:classification* / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000473:pathology; D014605:Uveitis / Q000188:drug therapy / Q000473:pathology*
D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface