Association of amyoplasia with gastroschisis, bowel atresia, and defects of the muscular layer of the trunk.
We reviewed 225 cases of amyoplasia, and the association of amyoplasia with gastroschisis and with monozygotic twinning was confirmed. In addition, an apparently increased association of bowel atresia and defects in the muscular layer of the trunk wall with amyoplasia was observed. The association of amyoplasia, monozygotic twinning, and these trunk wall defects strongly suggests that the pathogenesis of amyoplasia is linked to some type of vascular compromise.
D000009:Abdominal Muscles / Q000002:abnormalities* / Q000098:blood supply; D000015:Abnormalities, Multiple / Q000196:embryology / Q000453:epidemiology*; D000870:Anterior Horn Cells / Q000473:pathology; D001176:Arthrogryposis / Q000453:epidemiology*; D001955:British Columbia; D004200:Diseases in Twins / Q000453:epidemiology*; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D007409:Intestinal Atresia / Q000453:epidemiology*; D007422:Intestines / Q000098:blood supply; D011247:Pregnancy; D013116:Spinal Cord / Q000098:blood supply; D013270:Stomach / Q000002:abnormalities*; D014430:Twins, Monozygotic