[T- and B-cell functional activity in the immune response in viral carcinogenesis].
The functional activity of the spleen cells, their ability to produce antibody-forming cells on the model of the adoptive transfer, activity of T-helper-cells and B-precursor-cells of antibody producers in the tumour growth induced by monkey SA7 (C8) adenovirus were studied. The inoculation of the tumourigenic virus to the newborn mice CBA, inhibit antibody formation in the system of adoptive transfer already in the latent period with a sharp inhibition at the terminal stages of carcinogenesis. The helper activity is suppressed earlier than the activity of B-precursors of antibody producers. The obtained data indicate a considerable immunodepressive action of monkey adenovirus SA7 (C8).
D000261:Adenoviruses, Simian / Q000472:pathogenicity; D000818:Animals; D000831:Animals, Newborn; D000921:Antibody-Producing Cells / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D005260:Female; D006393:Hemangiopericytoma / Q000209:etiology / Q000276:immunology*; D007108:Immune Tolerance; D007114:Immunization / Q000379:methods; D007116:Immunization, Passive; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D013997:Time Factors
Issledovanie funktsional'noĭ aktivnosti T- i B-kletok v immunnom otvete pri virusnom kantserogeneze.