title: Experimental gingivitis around deciduous teeth in children with Down's syndrome.
abstract: Epidemiological studies have shown that there is a high prevalence and rapid progression of periodontal disease in children with Down's Syndrome (DS). In this respect, DS children exhibit a markedly different response compared with healthy children. In order to understand the reasons for this difference, a controlled study was set up to determine the extent and the quality of the differences in the early periodontal tissue response towards dental plaque in the deciduous dentition of DS children and matched control children. In a preliminary investigation, the gingival health was estimated by determining the bleeding tendency. 9 healthy children were selected from a group of 14 and matched with 9 DS children with respect to plaque development, sulcus depth and age. The DS children had a higher bleeding tendency than the matched controls. In the DS children, moreover, a correlation was found between bleeding tendency and age. No such correlation was found in the controls. After a period of intensive oral hygiene, all cleaning of teeth was discontinued for 21 days. The amount of plaque according to the plaque index, the gingival health according to the gingival index, and the amount of crevicular leucocytes and gingival exudate were assessed at days 0, 7, 14 and 21. During the experimental phase of the study, the amount of plaque increased at a similar rate in both groups. In the DS children, the development of gingival inflammation started earlier and was more extensive. It increased after day 14, whereas in the control children, the gingival inflammation seemed to stabilize at this time. The results of the present experimental study thus confirm earlier results from epidemiological studies.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D002648:Child; D002675:Child, Preschool; D003774:Dental Plaque Index; D004314:Down Syndrome / Q000503:physiopathology*; D005883:Gingival Crevicular Fluid; D005884:Gingival Hemorrhage / Q000175:diagnosis / Q000503:physiopathology; D005891:Gingivitis / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007958:Leukocyte Count; D013997:Time Factors; D014094:Tooth, Deciduous