Conditioned taste aversion to ethanol induced by zimeldine.
Conditioned taste aversions (CTA) were induced to both ethanol and saccharin solutions with the serotonin uptake inhibitor Zimeldine. When animals were pretreated with Zimeldine prior to the presentation of a novel flavour a CTA did not result. However, there is evidence that Zimeldine induces an unconditioned suppression of drinking. These results are discussed in terms of their relevance to Zimeldine's effects on voluntary ethanol consumption.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013649:Taste / Q000187:drug effects; D013997:Time Factors; D015031:Zimeldine / Q000494:pharmacology*
D012701:Serotonin; D015031:Zimeldine; D000431:Ethanol; D006916:5-Hydroxytryptophan