Influence of several aldehyde dehydrogenase and aldehyde reductase inhibitors on diamine oxidase in rat brain.
Pyrroline formation in rat brain was studied in presence of different inhibitors of AldDH, AldR, ADH and MAO. The inhibition of AldDH and AldR, but not of ADH and MAO significantly increased DAO activity. The results indicate that the use of appropriate aldehyde metabolizing enzymes inhibitors allows to better understand the role of diamine oxidase in rat brain putrescine catabolism.
D000426:Alcohol Dehydrogenase; D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors*; D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors*; D000447:Aldehydes / Q000378:metabolism; D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D011700:Putrescine / Q000378:metabolism; D011758:Pyrroles / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000447:Aldehydes; D008996:Monoamine Oxidase Inhibitors; D011758:Pyrroles; C013231:pyrroline; C006509:4-aminobutyraldehyde; D000429:Alcohol Oxidoreductases; D000426:Alcohol Dehydrogenase; C019642:alcohol dehydrogenase (NADP+); D000444:Aldehyde Dehydrogenase; D006631:Amine Oxidase (Copper-Containing); D011700:Putrescine