A phosphorylated, disulfide-linked membrane protein in murine cytotoxic T lymphocytes.
The previously determined sequence of the murine T-cell gamma gene and its transcription in cloned T lymphocytes suggests that the polypeptide encoded by this gene is generally present in cytotoxic T cells as a 33-kDa monomer in a disulfide-bonded dimer. The gamma chain is also expected to be phosphorylated because a sequence in its cytoplasmic domain is homologous to an active site for serine phosphorylation in the regulatory subunit of cAMP-dependent protein kinase. We describe here a cytotoxic-T-cell-associated phosphorylated protein, many of whose properties suggest that it may be the product of the T-cell gamma gene. Its phosphorylation is greatly enhanced by interleukin 2 stimulation.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002460:Cell Line; D004220:Disulfides; D007376:Interleukin-2; D008565:Membrane Proteins / Q000032:analysis* / Q000276:immunology; D051379:Mice; D010750:Phosphoproteins / Q000032:analysis* / Q000276:immunology; D010766:Phosphorylation; D013602:T-Lymphocytes, Cytotoxic / Q000032:analysis*; D006377:T-Lymphocytes, Helper-Inducer / Q000032:analysis
D000596:Amino Acids; D004220:Disulfides; D007376:Interleukin-2; D008565:Membrane Proteins; D010750:Phosphoproteins