The proliferative T-lymphocyte response to streptokinase.
Purified streptokinase was found to initiate a proliferative T-lymphocyte response. The response was characterized by dose-response and kinetics investigations. Streptokinase did not initiate any response when tested on T lymphocytes from newborns, thus indicating that the proliferative T-lymphocyte response to streptokinase in vitro is an antigen stimulated activation of T lymphocytes from individuals previously sensitized in vivo. Of healthy individuals, 40% (16 out of 40 tested) showed a significant proliferative response to streptokinase. Methylprednisolone, cyclosporin A, theophyllamine and verapamil all inhibited the streptokinase-stimulated proliferative T-lymphocyte responses in a dose-dependent manner.
D000328:Adult; D000628:Aminophylline / Q000494:pharmacology; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects; D002478:Cells, Cultured; D003524:Cyclosporins / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005312:Fetal Blood / Q000166:cytology; D006801:Humans; D007231:Infant, Newborn; D007700:Kinetics; D008213:Lymphocyte Activation; D008775:Methylprednisolone / Q000494:pharmacology; D013300:Streptokinase / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014700:Verapamil / Q000494:pharmacology
D003524:Cyclosporins; D000628:Aminophylline; D014700:Verapamil; D013300:Streptokinase; D008775:Methylprednisolone