[Combined effects of gamma rays, cis-diamminedichloroplatinum (CDDP) and systemic hyperthermia mastocytoma transplanted into muscle in the mouse].
Comparison was made between the effects of local irradiation of gamma rays, s. c. injection of cis-diamminedichloroplatinum (II) (CDDP), systemic hyperthermia and their combinations on the i. m. transplanted murine mastocytoma. Increase of the mean survival time (M. S. T.) by a factor of 1.72 and of 1.68 was achieved by a single irradiation at 20 Gy, given on day 5 after transplantation, and by injections of CDDP at 2 mg/kg, given s. c. on days 5 and 12 after transplantation, respectively. Increase of M. S. T. by a factor of 1.10 which was achieved with systemic hyperthermia of 41.8 degrees C of the core body temperature for 5 min, given twice, on days 5 and 12 after transplantation, was not statistically significant. The most effective one among all possible combinations within the 3 modalities was that of radiation and CDDP. Increase of M. S. T. was by a factor of 4.01.
D000818:Animals; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006824:Hybridization, Genetic; D006979:Hyperthermia, Induced; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000532:radiotherapy / Q000628:therapy*; D051379:Mice; D008805:Mice, Inbred A; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation
D002945:Cisplatin
Etude des effets combinés des rayons gamma, du cis-diamminedichloroplatinium (CDDP) et de l'hyperthermie systémique sur le mastocytome transplanté dans le muscle chez la souris.