Transferred B cells from autoimmune NZB/N mice fail to activate T suppressor cells.
T-cell-mediated suppression of the antibody response of autoimmune NZB/N mice to Type III pneumococcal polysaccharide (SSS-III) can readily be induced in situ by priming with a subimmunogenic dose of SSS-III; however, the transfer of either "young" (8 weeks old) or "old" (42 weeks old) SSS-III-primed B cells, which activates suppressor T cells in normal BALB/cByJ mice, fails to induce suppression of the antibody response in recipient NZB/N mice, regardless of the number of cells transferred or the time interval between transfer and immunization. Transfer of 51Cr-labeled B cells demonstrated that syngeneic primed B cells home to the spleens of NZB/N mice in somewhat lower numbers than in BALB/cByJ mice, although the differences observed may not be sufficient to explain the complete absence of activation of suppressor T cells. These findings suggest that B cells from autoimmune NZB/N mice are unable to activate T suppressor cells upon transfer; this disorder in a normal regulatory mechanism may be important in the pathogenesis of disease.
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000637:transplantation; D002634:Chemotaxis, Leukocyte; D005260:Female; D007116:Immunization, Passive; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008814:Mice, Inbred NZB / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D011135:Polysaccharides, Bacterial; C026604:pneumococcal polysaccharide, type III