Enzymatic cleavage of various fluorinated pyrimidine nucleosides to 5-fluorouracil and their antiproliferative activities in human and murine tumor cells.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D005467:Floxuridine / Q000378:metabolism* / Q000494:pharmacology; D005472:Fluorouracil / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000201:enzymology / Q000473:pathology; D013379:Substrate Specificity; D013939:Thymidine Phosphorylase / Q000378:metabolism; D014543:Uridine Phosphorylase / Q000378:metabolism
D005467:Floxuridine; D014543:Uridine Phosphorylase; D013939:Thymidine Phosphorylase; D005472:Fluorouracil; C025034:doxifluridine