[Alpha 1-antitrypsin phenotypes of healthy persons and chronic bronchitis patients].
The paper is concerned with phenotyping of alpha 1-antitrypsin using a method of isoelectric focusing in the polyacrylamide gel with ampholine (pH-4-6) in 1000 healthy persons and 583 patients with chronic bronchitis. Phenotype M was registered in 96 and 95.71% of the cases, respectively. The occurrence of heterozygous phenotypes was practically similar among the healthy persons as well as among the patients (4.0 and 4.29%, respectively). It was concluded that the heterozygous carrying of an alpha 1-antitrypsin deficit gene was of no particular importance in the development of chronic bronchitis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001991:Bronchitis / Q000097:blood* / Q000209:etiology / Q000235:genetics; D002908:Chronic Disease; D006579:Heterozygote; D006801:Humans; D007525:Isoelectric Focusing; D008875:Middle Aged; D010641:Phenotype; D012426:Russia; D000515:alpha 1-Antitrypsin / Q000032:analysis*
D000515:alpha 1-Antitrypsin
Fenotipy al'fa 1-antitripsina u zdorovykh i bol'nykh khronicheskim bronkhitom.