Cimetidine inhibition of dimaprit-induced writhing in the rat.
Intraperitoneal, but not intravenous administration of dimaprit (50-125 mg/kg) caused a dose-dependent writhing in the rat. This effect was blocked, again in a dose-dependent fashion, by cimetidine administered orally 1 h prior to dimaprit. Results obtained suggest that dimaprit induces a cimetidine-sensitive pain by acting at peripheral nociceptive terminals within the peritoneum. The specific (H2-receptor related) analgesic effect of cimetidine could explain its effectiveness in relieving epigastric pain of duodenal ulcer patients treated with the drug.
D000700:Analgesics; D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D017259:Dimaprit; D004305:Dose-Response Relationship, Drug; D005260:Female; D007274:Injections, Intraperitoneal; D051381:Rats; D013890:Thiourea / Q000037:antagonists & inhibitors*
D000700:Analgesics; D002927:Cimetidine; D013890:Thiourea; D017259:Dimaprit