Electron microscopy and immunohistochemistry of toxic and allergic effects of methylmethacrylate on the skin.
Prolonged exposure of rat tail skin to methylmethacrylate (MMA) caused a toxic effect on all types of epidermal cells as judged by electron microscopy. Myelin figures as a sign of degeneration of nerve processes were observed in the dermis. Immunohistochemistry and electron microscopy of MMA allergic patch tests in humans corresponded to observations seen with other allergens.
D000818:Animals; D009783:Dermatitis, Occupational / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007120:Immunochemistry; D008214:Lymphocytes / Q000276:immunology; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000633:toxicity*; D008854:Microscopy, Electron; D009431:Neural Conduction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects* / Q000276:immunology / Q000473:pathology
D008768:Methylmethacrylates; D020366:Methylmethacrylate