Influence of kappa and IgH genes on the T helper cell response to p-azobenzenearsonate tyrosine.
Immunization of mice with the p-azobenzenearsonate-L-tyrosine conjugate (ABA-Tyr) leads to the activation of ABA-specific T helper cells capable of proliferating in vitro in the presence of the corresponding antigen. This response is under a dual genetic regulation by H-2 and non-H-2 linked genes, and H-2d mice are high-responder. We demonstrate here, using strains congenic to BALB/c for chromosomes (Chr.) 6 or 12 that this T cell response is also influenced by kappa and IgH linked genes. Double congenic mice indicate that Chr.6 and Chr.12 genes have a complementary effect on the response which cannot be predicted solely by the alleles expressed on either of the two chromosomes. In addition, responses in Bailey's inbred recombinant mice allow a possible mapping of the Chr.12 gene at the 5' end of the IgH complex and of the VH-dextran gene family. The mechanisms which may account for the influence of immunoglobulin gene products on the ABA-specific T cell repertoire are discussed.
D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D002874:Chromosome Mapping; D004261:DNA Replication; D005803:Genes, Immunoglobulin; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D011995:Recombination, Genetic; D013045:Species Specificity; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010132:p-Azobenzenearsonate / Q000031:analogs & derivatives / Q000494:pharmacology*
D001391:Azo Compounds; D006183:H-2 Antigens; D007145:Immunoglobulin kappa-Chains; C000234:azobenzenearsonate-N-acetyl-L-tyrosine; D014443:Tyrosine; D010132:p-Azobenzenearsonate