Reversal by indomethacin of renal effects of dopamine in subjects with normal renal function.
In five subjects with normal renal function, intravenous dopamine, at a rate of 6 ug/kg/min, produces a renal vasodilation, increase in Na excretion and reduction in urinary osmolality, without modification in glomerular filtration rate. These effects were reversed by intravenous indomethacin (2 mg/kg), suggesting that the renal effects of dopamine might depend on normal prostaglandins production.
D000328:Adult; D018492:Dopamine Antagonists; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D008875:Middle Aged; D014882:Water-Electrolyte Balance / Q000187:drug effects
D018492:Dopamine Antagonists; D007213:Indomethacin