Cell-bound C3b stimulates human monocyte release of prostaglandin E and thromboxane B2.
Particle-bound C3b stimulated enhanced release of prostaglandin E and thromboxane B2 (TxB2) from human peripheral blood monocytes in vitro. Particle-bound C3b stimulation was correlated to the ability of the particles to bind to the monocytes. Monocytes stimulated with particle-bound and fluid-phase C3b always released more TxB2 than PGE. These data suggest that ligation of the C3b receptor on human monocytes results in enhanced arachidonic acid metabolism.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D003167:Complement Activation; D003179:Complement C3b / Q000502:physiology; D006801:Humans; D009000:Monocytes / Q000378:metabolism* / Q000648:ultrastructure; D011458:Prostaglandins E / Q000378:metabolism*; D011951:Receptors, Complement / Q000502:physiology*; D017463:Receptors, Complement 3b; D013929:Thromboxane B2 / Q000378:metabolism*
D001095:Arachidonic Acids; D011458:Prostaglandins E; D011951:Receptors, Complement; D017463:Receptors, Complement 3b; D016718:Arachidonic Acid; D013929:Thromboxane B2; D003179:Complement C3b