title: Penetration of ciprofloxacin into gynecological tissues following oral and intravenous administration.
abstract: Penetration activities of ciprofloxacin into female genital tract tissues were studied following a single oral administration of 500 mg and an intravenous injection of 100 mg. Serum and tissue concentrations were within the same order of magnitude 1 and 3 h after oral administration; 3 h after intake of ciprofloxacin, however, tissue concentrations exceeded the corresponding serum levels twofold. Similarly, tissue concentrations following intravenous injection exceeded the corresponding serum levels by 60-190% 0.5 h after injection and were consistently higher throughout the study period of 2 h. These data confirm that ciprofloxacin disposition is characterized by a remarkably pronounced diffusion into the extravascular space, generating tissue levels exceeding the minimal inhibitory concentrations of most pathogens severalfold.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002939:Ciprofloxacin; D005260:Female; D005836:Genitalia, Female / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D010053:Ovary / Q000378:metabolism; D011804:Quinolines / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism; D014621:Vagina / Q000378:metabolism
chemical_list: D011804:Quinolines; D002939:Ciprofloxacin