The effect of nicotinamide on N-methyl-N'-nitro-N-nitrosoguanidine induced killing and mutation.
Nicotinamide, an inhibitor of poly(ADP-ribose) synthesis has been found to increase the killing of Chinese hamster V-79 cells induced by N-methyl-N'-nitro-N-nitrosoguanidine in concentration dependent manner. Such treatment also decreased the induced mutation. The nature of the results obtained was similar to those obtained earlier with benzamide, another inhibitor.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D009154:Mutation / Q000187:drug effects*; D009536:Niacinamide / Q000494:pharmacology*; D013997:Time Factors
D008769:Methylnitronitrosoguanidine; D009536:Niacinamide