[Cytotoxicity of the lymphocytes of melanoma patients against autologous tumor cells and its in vitro enhancement].
Specific cytolytic and natural killer activity of peripheral blood lymphocytes was studied in 12 patients with metastatic melanoma. The cytolytic activity of lymphocytes against autologous tumor cells was found in 8 patients. It appeared significantly enhanced by pretreatment of tumor target cells with concanavalin A (Con A). The natural killer activity in all the patients was 2-10 times as high as the specific cytolytic activity. Stimulation of patient lymphocytes with autologous tumor cells or with the mixture of lymphocytes from 5 allogeneic donors induced the generation of highly active T killers possessing natural killer and specific antitumor cytolytic activity.
D000328:Adult; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D008545:Melanoma / Q000276:immunology* / Q000556:secondary; D008875:Middle Aged; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000276:immunology*
Tsitotoksichnost' limfotsitov bol'nykh melanomoĭ protiv autologichnykh opukholevykh kletok i ee usilenie in vitro.