Analysis of alloantigen-specific suppressor T cells.
The intravenous administration of allogeneic spleen cells successfully induced two distinct subsets of alloantigen-specific suppressor T cells that function at either the induction phase or the effector phase of alloantigen-specific DTH responses. The induction phase suppressor T cells were found to be Lyt2-, and were not genetically restricted by H-2 region genes. The effector phase suppressor T cells are Lyt2+, and their activity is controlled by genes within the H-2 region. The effector phase suppressor T cells mediate antigen-dependent bystander suppression, provided the appropriate alloantigen is present at the site of the immune responses. This effector phase suppression requires cyclophosphamide-sensitive targets. The results of this study suggest that allospecific suppressor T cells and hapten-specific suppressor T cells have a similar mechanism of action.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D006183:H-2 Antigens / Q000235:genetics; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007518:Isoantibodies / Q000032:analysis; D007519:Isoantigens / Q000032:analysis*; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D013154:Spleen / Q000166:cytology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D006183:H-2 Antigens; D007518:Isoantibodies; D007519:Isoantigens; C029805:Lyt antibodies; D003520:Cyclophosphamide