Bilateral virilizing adrenal tumor in a 17 year old woman.
We report on a 17 year old female patient with amenorrhea, hirsutism and slight acne. Hormonal blood analyses showed markedly increased levels for dehydroepiandrosteronesulfate, testosterone and androstenedione. Ultrasound investigation revealed a large tumor above the left kidney and a small area above the right kidney, suspicious for a tumor on the contralateral side. This was confirmed by angiography. During surgery, bilateral tumors were removed. Pathological diagnosis was made as bilateral adenomas of the adrenal cortex. Postoperatively, an impressive normalization was observed, accompanied by a rapid decrease of the elevated hormone concentrations. This case is the first report of a bilateral occurrence of a virilizing tumor of the adrenal cortex.
D000236:Adenoma / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D000293:Adolescent; D000306:Adrenal Cortex Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D000735:Androstenedione / Q000097:blood; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D013739:Testosterone / Q000097:blood; D014770:Virilism / Q000209:etiology*
D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate