Activities of glycolytic enzymes in some brain areas of thyroidectomized rats and their response to replacement therapy.
Glycolytic metabolism has been assessed by studying a set of key enzymes, in anterior cortex, amygdala, hypothalamus septum and hippocampus, in thyroidectomized rats. The reversibility of the changes induced by the thyroidectomy has been assessed by replacement therapy. In thyroidectomized rats the hexokinase activity was significantly decreased in anterior cortex and hypothalamus. The increase in phosphofructokinase and pyruvate kinase activity was probably due to an increase in cellular energy requirements. Hexokinase activity was best restored by treatment with L-thyroxine (T4) or T4+ propylthiouracil (PTU). The low response of pyruvate kinase activity in all treated animals could suggest that this metabolic step is the least reversible.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D006019:Glycolysis; D006593:Hexokinase / Q000032:analysis*; D007037:Hypothyroidism / Q000188:drug therapy / Q000201:enzymology*; D007770:L-Lactate Dehydrogenase / Q000032:analysis*; D008297:Male; D010732:Phosphofructokinase-1 / Q000032:analysis*; D011193:Potassium Iodide / Q000494:pharmacology / Q000627:therapeutic use; D011441:Propylthiouracil / Q000494:pharmacology / Q000627:therapeutic use; D011770:Pyruvate Kinase / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology / Q000627:therapeutic use; D014284:Triiodothyronine / Q000494:pharmacology / Q000627:therapeutic use
D014284:Triiodothyronine; D011193:Potassium Iodide; D011441:Propylthiouracil; D007770:L-Lactate Dehydrogenase; D006593:Hexokinase; D010732:Phosphofructokinase-1; D011770:Pyruvate Kinase; D013974:Thyroxine