Relationships among maternal and fetal amino acid blood concentrations and amniotic fluid amino acid levels in pregnant rhesus monkeys.
This study was designed to explore relationships among maternal and fetal amino acid blood concentrations and amniotic fluid amino acid levels in pregnant rhesus monkeys. Although there was no constant pattern for all amino acids in the three body fluids, we observed specific patterns for most neutral amino acids, imino acids, and acidic amino acids relative to their concentrations in maternal blood, fetal blood, and amniotic fluid. Moreover, there was no correlation between fetal phenylalanine blood levels and phenylalanine concentrations in amniotic fluid indicating that amniotic fluid phenylalanine levels would not be useful to monitor fetal phenylalanine blood concentrations during pregnancy.
D000596:Amino Acids / Q000032:analysis* / Q000097:blood; D000653:Amniotic Fluid / Q000032:analysis*; D000818:Animals; D005260:Female; D010134:Fenclonine / Q000008:administration & dosage; D005312:Fetal Blood / Q000032:analysis*; D008253:Macaca mulatta; D010649:Phenylalanine / Q000008:administration & dosage / Q000097:blood; D011247:Pregnancy
D000596:Amino Acids; D010649:Phenylalanine; D010134:Fenclonine