[Heterogeneity of purinergic P2 receptors at the level of the caudal artery of the rat and the saphenous vein of the dog].
Phentolamine (10(-5) M) and an inhibitor of the lipoxygenase pathway, nordihydroguaiaretic acid (N. D. G. A.; 8 10(-6) M) antagonized the ATP induced contraction but not antagonized the UTP induced contraction on both rat tail artery and dog saphenous vein. We conclude that the receptors to ATP are distinct from receptors to UTP and that the P2 purinoceptors are an heterogeneous group.
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D001158:Arteries / Q000502:physiology*; D004285:Dogs; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D011983:Receptors, Purinergic / Q000187:drug effects / Q000502:physiology*; D012501:Saphenous Vein / Q000502:physiology*; D013045:Species Specificity; D013623:Tail; D014500:Uracil Nucleotides / Q000494:pharmacology*; D014544:Uridine Triphosphate / Q000494:pharmacology*
D011983:Receptors, Purinergic; D014500:Uracil Nucleotides; D000255:Adenosine Triphosphate; D014544:Uridine Triphosphate
Hétérogénéité des récepteurs purinergiques P2 au niveau de l'artère caudale du rat et de la veine saphène du chien.