Lipid peroxidation caused by chinoform-ferric chelate in cultured neural retinal cells.
Incorporation of chinoform-ferric chelate was demonstrable in cultured neural retinal cells of chick embryos after 1 h of incubation, and the lipid peroxide level in the cells was increased strikingly 1 h thereafter. On the other hand, free ferric ions were scarcely incorporated into the cells, and a significant increase in the lipid peroxide level in the cells was not observed. These data indicate that chinoform is carrier of iron for its passage through cell membranes and that the incorporated iron induces lipid peroxidation which in turn leads to neural cell degeneration.
D000818:Animals; D002478:Cells, Cultured; D002614:Chelating Agents / Q000378:metabolism / Q000494:pharmacology; D002712:Chlorides; D007464:Clioquinol / Q000494:pharmacology* / Q000633:toxicity; D005290:Ferric Compounds / Q000494:pharmacology*; D006912:Hydroxyquinolines / Q000494:pharmacology*; D007501:Iron / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000096:biosynthesis*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D012160:Retina / Q000187:drug effects* / Q000378:metabolism
D002614:Chelating Agents; D002712:Chlorides; D005290:Ferric Compounds; D006912:Hydroxyquinolines; D008054:Lipid Peroxides; D007464:Clioquinol; D007501:Iron; C024555:ferric chloride