Uptake of 77Br-spiperone in the striata of schizophrenic patients and controls.
Twelve patients with a diagnosis of schizophrenia and thirteen control subjects were injected with 77Br-bromospiperone and scanned using single photon emission tomography after 16 h. Although a statistically significant increase in patients by comparison with controls could be demonstrated, wide variations in specific activity of the ligand preclude a firm conclusion. In two patients but no controls an asymmetry in striatal uptake was noted, the uptake on the left being less than that on the right.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000378:metabolism; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011954:Receptors, Dopamine / Q000378:metabolism; D017448:Receptors, Dopamine D2; D012559:Schizophrenia / Q000378:metabolism*; D013134:Spiperone / Q000031:analogs & derivatives*; D014055:Tomography, Emission-Computed
D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D013134:Spiperone; C026326:4-bromospiperone