[Treatment of epithelial cancers of the ovary in advanced stages with surgery and cisplatin chemotherapy].
Seventy-one patients with advanced epithelial ovarian carcinoma were treated at the Centre Jean Perrin between May 1979 and December 1983. Following an initial laparotomy performed for staging and maximum cytoreductive surgery, six to twelve courses of chemotherapy were delivered with cis-platinum; 43 patients underwent a second look operation (S.L.O.). The results of initial surgery, chemotherapy and S.L.O. are discussed: survival rate is 57% at 3 years for stage III. 38% complete remission induced by chemotherapy were proved by negative S.L.O. after primary surgery with residual disease. Initial complete debulking and negative S.L.O. were significant factors that improved prognosis. Improvement of survival expectancy by removal of all macroscopic residual disease at S.L.O. remains to be proved. Treatment after S.L.O. is still under discussion.
D000328:Adult; D000368:Aged; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D012086:Reoperation
D002945:Cisplatin
Traitement des cancers épithéliaux de l'ovaire aux stades avancés par chirurgie et chimiothérapie avec cisplatine.