[Population-demographic and clinico-genetic characteristics of Huntington chorea in one region of Azerbaijan].
The data are presented on prevalence and clinical patterns of Huntington disease in Shamkhor region of Azerbaijan, where about 126.8 thousand inhabitants live. Population, demographic and genealogical data show that high prevalence of Huntington disease in that region is determined by the founder effects, reinforced later by extended reproduction of the population. Linkage analysis using the affected sib-pair method failed to reveal a linkage between Huntington's chorea locus and HLA, AB0, MN systems. Significant probability of linkage to Huntington's chorea locus was calculated for Gc marker.
D000328:Adult; D000368:Aged; D001382:Azerbaijan; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005828:Genetics, Population; D006801:Humans; D006816:Huntington Disease / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D005819:Genetic Markers
Populiatsionno-demograficheskaia i kliniko-geneticheskaia kharakteristika khorei Gentingtona v odnom iz raĭonov Azerbaijana.