Restoration of suppressor T-cell functions in children with AIDS following intravenous gamma globulin treatment.
Suppressor T-cell function was analyzed in seven children with acquired autoimmunodeficiency syndrome (AIDS) or AIDS-related complex (ARC). Four of the patients had markedly increased serum IgG levels. All patients had elevated percentages and absolute numbers of peripheral blood T8 cells. In vitro concanavalin A generation of suppressor cells for T-cell mitogenic responses and suppression of pokeweed mitogen-driven immunoglobulin secretion were diminished in all patients. After intravenous treatment with gamma globulin, four patients regained in vitro suppression of pokeweed mitogen-driven gamma globulin secretion. Treatment with intravenous gamma globulin also modified in vitro suppressor T-cell functions in children with AIDS or ARC.
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism / Q000627:therapeutic use*; D007223:Infant; D007275:Injections, Intravenous; D007376:Interleukin-2; D007770:L-Lactate Dehydrogenase / Q000097:blood; D013491:Suppressor Factors, Immunologic; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
D007074:Immunoglobulin G; D007376:Interleukin-2; D013491:Suppressor Factors, Immunologic; D003208:Concanavalin A; D007770:L-Lactate Dehydrogenase