title: The cell-mediated response of the guinea pig's middle ear.
abstract: In this project, we studied the cell-mediated response of guinea pig's middle ear. The specific objective was to characterize rejection of skin grafts on the back (allo- and iso-grafts) after primary stimulation (iso- or allo-) in the ear or on the back. The method used was the mixed lymphocyte response with and without phytohemagglutinin (PHA). Preliminary results showed that the middle ear is able to mount a normal immune response, both locally and systemically. Such basic studies will help us to understand the otologic immune response as a whole and may shed some light on the immune phenomena observed in middle ear transplantations.
mesh_terms: D000818:Animals; D004432:Ear, Middle / Q000276:immunology* / Q000637:transplantation; D006168:Guinea Pigs / Q000235:genetics; D007111:Immunity, Cellular; D007959:Lymphocyte Culture Test, Mixed; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic