Autoreactive or self restricted?
Putative major histocompatibility complex (MHC) class II-specific T cell clones were isolated from nominal antigen-primed T cell populations propagated in vitro under antigen selection. However, unlike the proliferative responses of nominal antigen-specific, MHC class II-restricted T cell clones derived from the same population, the former's MHC-specific proliferative responses required that the culture medium be supplemented with serum. The role of xenogeneic antigens in the generation of this category of "autoreactive" T cells is discussed.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001790:Blood Physiological Phenomena; D002417:Cattle; D003470:Culture Media; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007108:Immune Tolerance; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D003470:Culture Media; D000949:Histocompatibility Antigens Class II