[Allopurinol-induced kidney failure with hepatitis and squamous dermatitis in pre-existing kidney insufficiency].
We report on a female patient with analgetic nephropathy in whom allopurinol therapy was started because of asymptomatic hyperuricemia and who 2 months later developed a syndrome characterized by icteric hepatitis, exfoliative dermatitis and progressive renal failure. After discontinuation of allopurinol and temporary peritoneal dialysis the patient recovered from the initially threatening condition. Analysis of case reports from the literature indicates that this syndrome is due to the allopurinol metabolite oxypurinol and is most frequently observed in patients with renal failure on concomitant treatment with diuretics.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D000493:Allopurinol / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000139:chemically induced*; D003873:Dermatitis, Exfoliative / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000150:complications; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D000493:Allopurinol
Allopurinol(Zyloric)-induziertes Nierenversagen mit Hepatitis und squamöser Dermatitis bei vorbestehender Niereninsuffizienz.