title: The effect of tension on collagen remodelling by fibroblasts: a stereological ultrastructural study.
abstract: Peak levels of collagen phagocytic activity by fibroblasts during scar maturation have been shown to coincide with a reorientation of major fibre bundles in a process analogous to Wolff's Law. This activity has been shown to increase when greater tension exists across the scar. In this study, the influences of reduced tension on collagen remodeling was studied. In two groups of five rats the right achilles tendon was either: transected at its muscle insertion or was exposed in a similar fashion but left intact. The tendon samples were retrieved five days following initial surgery with a third group of five rats serving as a source of control tendon. Relative volume of collagen phagocytosis was measured at an ultrastructural level using stereological methods. No significant influence of reduced tension on collagen phagocytosis was observed. The average relative volume of fibroblast cytoplasm was significantly increased in the transected tendon. This may represent an inductive influence of as yet undetermined nature.
mesh_terms: D000125:Achilles Tendon / Q000502:physiology* / Q000648:ultrastructure; D000818:Animals; D003094:Collagen / Q000378:metabolism*; D003593:Cytoplasm / Q000648:ultrastructure; D005347:Fibroblasts / Q000502:physiology / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D010587:Phagocytosis; D051381:Rats; D011919:Rats, Inbred Strains; D014617:Vacuoles / Q000378:metabolism / Q000648:ultrastructure; D014945:Wound Healing
chemical_list: D003094:Collagen