The effect of LHRH analogs on pregnancy in the baboon.
Thirty-three baboons were maintained throughout their peri-ovulatory period in group enclosures with fertile males. They received treatment on days 14-19 of presumed pregnancy with either twice daily injection of 50 micrograms of an LHRH agonist or of 2 mg of an LHRH antagonist. Three pregnancies from 14 cycles were maintained in each of the treatment groups as compared to 5 of 14 in controls. Four abortions were noted but as 1 occurred in a control group the response could not be attributed to treatment. The agonist had no apparent effect on urinary progestins in nonpregnant animals but both analogs did cause a transient decline in pregnant animals. Results indicated that LHRH analogs are not suitable agents for early pregnancy termination under the present treatment regimen.
D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017274:Nafarelin; D010215:Papio; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011276:Pregnanediol / Q000031:analogs & derivatives / Q000652:urine
C022270:pregnanediol-3 alpha-glucuronide; D017274:Nafarelin; D007987:Gonadotropin-Releasing Hormone; C035819:LHRH, N-Ac-(4-Cl-Phe)(1,2)-Trp(3)-Arg(6)-AlaNH2(10)-; D011276:Pregnanediol