Comparing 2.5%, 5%, and 10% benzoyl peroxide on inflammatory acne vulgaris.
A 2.5% formulation of benzoyl peroxide was compared with its vehicle, and with a 5% and a 10% proprietary benzoyl peroxide gel preparation in three double-blind studies involving 153 patients with mild to moderately severe acne vulgaris. The 2.5% benzoyl peroxide formulation was more effective than its vehicle and equivalent to the 5% and 10% concentrations in reducing the number of inflammatory lesions (papules and pustules). Desquamation, erythema, and symptoms of burning with the 2.5% gel were less frequent than with the 10% preparation but equivalent to the 5% gel. The 2.5% formulation also significantly reduced Propionibacterium acnes and the percentage of free fatty acids in the surface lipids after 2 weeks of topical application.
D000152:Acne Vulgaris / Q000150:complications / Q000188:drug therapy*; D000287:Administration, Topical; D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy*; D001585:Benzoyl Peroxide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D010545:Peroxides / Q000627:therapeutic use*; D011425:Propionibacterium acnes / Q000187:drug effects
D005227:Fatty Acids; D010545:Peroxides; D001585:Benzoyl Peroxide