Increased activity of four glycolytic enzymes in cultured fibroblasts from cystic fibrosis patients.
The mean levels of activity of hexokinase, phosphofructokinase, pyruvate kinase and lactate dehydrogenase were found to be significantly higher in fibroblasts from cystic fibrosis patients than in those from age-matched controls and heterozygotes. This indicates that the activity of the glycolytic pathway is increased in fibroblasts from cystic fibrosis patients.
D002478:Cells, Cultured; D003550:Cystic Fibrosis / Q000201:enzymology* / Q000235:genetics; D005347:Fibroblasts; D006019:Glycolysis; D006579:Heterozygote; D006593:Hexokinase / Q000378:metabolism; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D010732:Phosphofructokinase-1 / Q000378:metabolism; D011770:Pyruvate Kinase / Q000378:metabolism
D007770:L-Lactate Dehydrogenase; D006593:Hexokinase; D010732:Phosphofructokinase-1; D011770:Pyruvate Kinase