Biochemical balance in the energy metabolism of fetal organs after perfusing the amniotic cavity with oxygenated fluorocarbon.
In order to determine the oxygen-dependent energy balance after perfusing the amniotic cavity with oxygenated fluorocarbon, hearts and livers of 30 rabbits [correction of rat] fetuses were investigated on the 28th day of gestation in a double-blind study 20 min after complete interruption of the uterine blood supply. ATP, creatine phosphate, glucose, lactate and glycerine were quantitatively measured by direct spectrofluorometry. The results show a tendency towards higher energy reserves after fluorocarbon treatment. However, under the described experimental conditions the oxygen supply seems yet too small for clinical purposes.
D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects*; D005318:Fetal Heart / Q000187:drug effects / Q000378:metabolism*; D005333:Fetus / Q000187:drug effects / Q000378:metabolism*; D005466:Fluorocarbons / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D010100:Oxygen / Q000494:pharmacology*; D011817:Rabbits
D005466:Fluorocarbons; D010100:Oxygen