title: Insulin and IGF receptors are developmentally regulated in the chick embryo eye lens.
abstract: We have previously reported that insulin-like growth factor (IGF) receptors appear to predominate over insulin receptors in early stages of embryogenesis in the chick (days 2-3 whole embryo membranes). Overall, [125I]IGF I and II binding to specific receptors was maximal when the rate of brain growth is highest. In the present study we used the embryonic chick lens, a well-defined tissue composed of a single type of cell, to analyse whether changes of insulin and IGF I binding are correlated with changes in growth rate and differentiation state of the cells. We show that both insulin receptors and IGF receptors are present in the lens epithelial cells, and that each type is distinctly regulated throughout development. While there is a direct correlation between IGF-binding capability and growth rate of the cells, there is less relation to differentiation status and embryo age. Insulin receptors, by contrast, appear to be mostly related to the differentiated state of cells, decreasing sharply in fibers, irrespective of their developmental age.
mesh_terms: D000818:Animals; D002642:Chick Embryo; D005314:Embryonic and Fetal Development; D004848:Epithelium / Q000378:metabolism; D007328:Insulin / Q000031:analogs & derivatives / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007700:Kinetics; D007908:Lens, Crystalline / Q000196:embryology* / Q000378:metabolism; D011972:Receptor, Insulin / Q000378:metabolism*; D017451:Receptors, Somatomedin
chemical_list: D007328:Insulin; D017451:Receptors, Somatomedin; C008147:insulin, iodo-; D007334:Insulin-Like Growth Factor I; D011972:Receptor, Insulin