The effect of rheumatoid factor on the clearance of endogenous immune complexes formed in low-affinity mice during the induction of immune complex disease.
Intravenous injection of rheumatoid factor (RF) had a marked effect on the clearance kinetics of immune complexes (IC) formed in vivo during induction of chronic immune complex disease in low-affinity mice. RF resulted in a significant increase in IC level and clearance time in 64% of mice with circulating IC after antigen injection, suggesting that RF may alter the handling of potentially pathogenic IC which localize in the renal capillaries causing glomerulonephritis.
D000818:Animals; D000915:Antibody Affinity; D000936:Antigen-Antibody Complex / Q000276:immunology*; D007105:Immune Complex Diseases / Q000276:immunology*; D008657:Metabolic Clearance Rate; D051379:Mice; D012217:Rheumatoid Factor / Q000276:immunology*
D000936:Antigen-Antibody Complex; D012217:Rheumatoid Factor