Differential effect of cyclosporin A (CyA) on IgE response: role of CyA-induced suppressor cells.
Administration of cyclosporin A (CyA, 30 mg/kg) for the five days following immunization of Brown Norway rats with DNP14-OVA in alum abolished the primary total and specific IgE response, whereas this treatment had no significant effect on the secondary IgE response. On the contrary, with a single injection of CyA on the day of priming, the secondary IgE response only is abolished. The inhibition of the secondary IgE response could be attributed to the induction by a single dose of CyA of nylon wool-adherent spleen cells, as shown by passive transfer experiments. CyA might thus affect the IgE response variously depending on single or repeated administrations.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003524:Cyclosporins / Q000494:pharmacology*; D007116:Immunization, Passive; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007700:Kinetics; D008297:Male; D051381:Rats; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*
D003524:Cyclosporins; D007073:Immunoglobulin E