Expression of common acute lymphoblastic leukemia-associated antigen on germ cell tumor.
A mediastinal germ cell tumor is described that reacts with the anti-common acute lymphoblastic leukemia-associated antigen antibody J5 using both immunofluorescence and immunoperoxidase techniques. This antigen has been reported recently on various cell lines including melanoma, colon, and breast. It has also been seen on normal fibroblasts and peripheral granulocytes. This is believed to be the first description of a solid nonlymphoid neoplasm possessing this antigen, and the implications regarding prognosis and therapy are discussed.
D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis*; D004407:Dysgerminoma / Q000276:immunology*; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000276:immunology*; D015260:Neprilysin
D000951:Antigens, Neoplasm; D015260:Neprilysin