Atrial natriuretic factor is biologically active also in the absence of vasopressin: studies on Brattleboro-strain diabetes insipidus rats.
Since atrial natriuretic factor (ANF) has been shown to inhibit vasopressin secretion, the role of this effect in the acute biological actions of ANF was investigated using Brattleboro-strain diabetes insipidus (DI) rats. Under thiobarbital anesthesia, synthetic rat ANF of a 25 amino acid sequence was administered intravenously as a bolus (8 micrograms/kg) into the jugular vein. The urine volume, urinary sodium and potassium concentration, blood pressure, and heart rate were determined. It was found that ANF administered exogenously can exhibit its diuretic, natriuretic and vasorelaxant activities even in the absence of vasopressin. This indicates that the inhibition of vasopressin secretion is not an indispensible mechanism for acute biological effects of ANF.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology / Q000502:physiology*; D009320:Atrial Natriuretic Factor / Q000494:pharmacology / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D003919:Diabetes Insipidus / Q000503:physiopathology*; D004231:Diuresis / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007671:Kidney Concentrating Ability / Q000187:drug effects; D008297:Male; D011188:Potassium / Q000652:urine; D051381:Rats; D011910:Rats, Brattleboro; D012964:Sodium / Q000652:urine
D001127:Arginine Vasopressin; D009320:Atrial Natriuretic Factor; D012964:Sodium; D011188:Potassium