title: Mediation by gonadal steroids of plasma beta-endorphin and LH in castrated female and male rats.
abstract: Immunoreactive beta-endorphin (IR-BE) was significantly decreased and luteinizing hormone (LH) significantly increased in female rats castrated for four weeks. Forty eight hours after a single injection of estradiol benzoate (EB), IR-BE levels increased, and LH levels were reduced. On the afternoon following the administration of a second injection of EB given six hours earlier, IR-BE levels were reduced below control values, whereas LH levels were significantly elevated. There was no change in IR-BE levels during the remainder of that afternoon whereas LH levels decreased over time. Similar to female rats, IR-BE was diminished and LH increased in castrated male rats. IR-BE was increased significantly above those values observed in intact animals 24 hr after a single injection of TP and returned to control levels by 48 hr after administration of TP. Injection of TP reduced LH to levels observed prior to castration. These findings suggest that gonadal steroids exert a feedback on the release of IR-BE from the pituitary of female and male rats opposite to their feedback effect on the release of pituitary gonadotropins.
mesh_terms: D000818:Animals; D002369:Castration; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D004723:Endorphins / Q000097:blood*; D004967:Estrogens / Q000502:physiology; D005246:Feedback; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology / Q000502:physiology*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D013739:Testosterone / Q000502:physiology; D001615:beta-Endorphin
chemical_list: D004723:Endorphins; D004967:Estrogens; D012739:Gonadal Steroid Hormones; D013739:Testosterone; D001615:beta-Endorphin; D007986:Luteinizing Hormone; D003346:Corticotropin-Releasing Hormone