[Effect of bone marrow opioid peptides on antibody formation in the productive phase of the immune response].
The cells of intact spinal cord produce a group of biologically active peptides--myelopeptides (MP) stimulating antibody formation at peak of immune response and exerting an analgesic endorphin-like effect. The experiments on comparative studies of antibody-stimulating effect of synthetic opioid peptides and MP have shown that the mixture of opioid substances composed in aliquots corresponding to their content in MP has an antibody-stimulating effect similar to that of MP. Synthetic beta-endorphin also enhances the antibody formation during the productive phase of immune response at doses 1000-fold lower than its MP level. Leu- and met-enkephalins have no antibody-stimulating effect. An antagonist opiate, naloxone, blocks the antibody-stimulating activity of both opiates and MP. A close correlation between antibody-stimulating and analgetic endorphin-like MP activity has been established.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D001853:Bone Marrow; D066298:In Vitro Techniques; D009270:Naloxone / Q000494:pharmacology; D009842:Oligopeptides; D010455:Peptides / Q000494:pharmacology*; D013552:Swine; D001615:beta-Endorphin / Q000494:pharmacology
D009842:Oligopeptides; D010455:Peptides; C048617:myelopeptides; D009270:Naloxone; D001615:beta-Endorphin
Vliianie opiodnykh peptidov kostnogo mozga na antiteloobrazovanie v produktivnuiu fazu immunnogo otveta.