Leiner's disease associated with diminished third component of complement.
A 6-week-old female infant experienced recurrent diarrhea, wasting, and generalized seborrheic dermatitis. She manifested defective yeast opsonization and concomitant very low level of the third component of complement (C3). This is the first report of Leiner's disease associated with diminished C3. It corroborates evidence to suggest that yeast opsonic activity of normal human serum is dependent on C3 levels.
D003176:Complement C3 / Q000172:deficiency*; D003873:Dermatitis, Exfoliative / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009895:Opsonin Proteins / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000378:metabolism
D003176:Complement C3; D009895:Opsonin Proteins