Characterization of Japanese éncephalitis virus-induced suppressor T cells and their products for delayed type hypersensitivity.
Intraperitoneal inoculation with Japanese encephalitis virus (JEV) induces the generation of T suppressor cells for delayed type hypersensitivity (Ts-DTH) in Swiss albino mice. The Ts-DTH are hydrocortisone resistant, partially sensitive to X-irradiation and the membrane phenotype of Ts cells is Ly I+. Ts-DTH suppression is mediated through the production of soluble suppressor factor (SF-DTH). SF-DTH is non-dialysable but passes through 450 nm filter and does not sediment after centrifugation at 100,000 g for 2 h; chromatography on Sephadex G-100 indicates an approximate molecular weight of 12,000.
D000818:Animals; D004351:Drug Resistance; D004664:Encephalitis Virus, Japanese / Q000276:immunology*; D006854:Hydrocortisone / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D013154:Spleen / Q000276:immunology; D013491:Suppressor Factors, Immunologic; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects
D013491:Suppressor Factors, Immunologic; D006854:Hydrocortisone