Sclerosing cholangitis from intraarterial floxuridine.
The development of biliary strictures simulating sclerosing cholangitis is now well-known. We report a patient undergoing intraarterial chemotherapy for metastatic colon cancer of the liver in whom segmental intrahepatic biliary strictures occurred remote from known metastases. The patient remains alive 3-4 years after documented liver metastases with severe progressive portal hypertension, hypersplenism, and fat malabsorption. A table of cases so far reported is given.
D000230:Adenocarcinoma / Q000188:drug therapy; D000368:Aged; D001652:Bile Ducts / Q000473:pathology*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D005467:Floxuridine / Q000009:adverse effects* / Q000627:therapeutic use; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000009:adverse effects*; D008105:Liver Cirrhosis, Biliary / Q000139:chemically induced*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D012598:Sclerosis; D012811:Sigmoid Neoplasms / Q000601:surgery; D014057:Tomography, X-Ray Computed
D005467:Floxuridine