[Effects of glucagon and epinephrine on the rat liver: oxidative phosphorylation and ultrastructure].
Twenty minutes after i.v. injection of 1.5 micrograms/100 g epinephrine, the phosphorylation rates of rat liver mitochondria were increased by 30-40%. Treatment with cycloheximide or actinomycin D 20 min before epinephrine or glucagon (10 micrograms/100 g, i.v.) injection blocked much of the respiratory activation by these hormones. The treatment with glucagon or epinephrine (20 min) provoked an important development of rough endoplasmic reticulum of which cisternae were closely associated with the mitochondria, and an appearance of abundant ribosomes. We observed close structural contact between mitochondria, and also between smooth endoplasmic reticulum membranes and mitochondria. Thus, glucagon and epinephrine provoked an early stimulation of mRNA and protein synthesis which could be involved in the activation of mitochondrial energy metabolism.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D004721:Endoplasmic Reticulum / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology*; D005934:Glucagon / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D051381:Rats
D000244:Adenosine Diphosphate; D005934:Glucagon; D004837:Epinephrine
Effets du glucagon et de l'adrénaline sur le foie de rat: phosphorylations oxydatives et ultrastructure.