Platelet reactivity, fibrinogen and smoking.
40 young healthy male volunteers (20 habitual smokers and 20 non-smokers) were investigated with respect to platelet reactivity, plasma fibrinogen and coagulation factor VIII. Smokers had significantly lower systolic blood pressures and higher venous platelet counts. The results for ADP-induced platelet aggregation, plasma concentrations for the 2 alpha-granule proteins, beta-thromboglobulin and platelet factor 4, did not differ between the 2 study groups involved; nor was there any difference between serum thromboxane B2 formation or plasma factor VIII:C activity. However, as compared to non-smokers, plasma fibrinogen levels were significantly higher among the smokers.
D001777:Blood Coagulation; D001792:Blood Platelets / Q000502:physiology*; D005169:Factor VIII / Q000502:physiology; D005340:Fibrinogen / Q000502:physiology*; D006801:Humans; D008297:Male; D010974:Platelet Aggregation; D010978:Platelet Factor 4 / Q000097:blood; D012907:Smoking; D013929:Thromboxane B2 / Q000097:blood; D001620:beta-Thromboglobulin / Q000097:blood
D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; D013929:Thromboxane B2; D005169:Factor VIII; D005340:Fibrinogen