[Protective effect of aminazine in ischemia and re-perfusion of an isolated heart].
The effect of cholorpromazine on the degree of reduction of the myocardial contractility during reperfusion of the isolated heart after 5 minutes total ischaemia of rats or after 40 minutes ligation of the left coronary artery of the guinea pigs has been studied. It has been shown that in both cases the preparation shows protective effect. In experiments on vesicles of sarcoplasmic reticulum (SR) of rat's skeletal muscles has been established that chlorpromazine prevents from calcium pump of SR dissociation caused by lipid peroxidation activity or by adding phospholipase A2 to SR fragments. It has been concluded that chlorpromazine protective effect depends on its membranostabilized action.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002746:Chlorpromazine / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000378:metabolism / Q000503:physiopathology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000201:enzymology
D008054:Lipid Peroxides; D000252:Calcium-Transporting ATPases; D002118:Calcium; D002746:Chlorpromazine
Issledovanie zashchitnogo deĭstviia aminazina pri ishemii i reperfuzii izolirovannogo serdtsa.