Differential analgetic actions of amphetamine enantiomers in the mouse: a drug-drug interaction study.
A series of agents were tested for their ability to interact with the analgetic actions of either d-amphetamine (d-AMP) or l-amphetamine (l-AMP), or morphine in rats using the hot plate procedure. The analgetic action of l-AMP was potentiated by morphine and slightly antagonized by naloxone; it was antagonized by clonidine, alpha-MT, yohimbine, fluoxetine and metergoline, but enhanced by PCPA. The analgetic action of morphine was antagonized by both naloxone and PCPA. The analgetic actions of l-AMP and morphine appear to involve different biogenic amine systems.
D000661:Amphetamine / Q000494:pharmacology*; D000700:Analgesics; D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D004347:Drug Interactions; D010134:Fenclonine / Q000494:pharmacology; D005473:Fluoxetine / Q000494:pharmacology; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010868:Pimozide / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013237:Stereoisomerism
D000700:Analgesics; D005473:Fluoxetine; D008711:Metergoline; D010868:Pimozide; D012701:Serotonin; D009270:Naloxone; D009020:Morphine; D000661:Amphetamine; D010134:Fenclonine; D003913:Dextroamphetamine; D004298:Dopamine; D009638:Norepinephrine