[Behavioral and EEG signs of the convulsive action of kynurenine and quinolinic acid in cats].
Administration of quinolinic acid but not L-kynurenine into the cat caudate nucleus was found to produce the appearance of epileptiform charges in the EEG with concomitant behavioral convulsions. A combination of quinolinic acid injections with systemic administration of penicillin resulted in the development of the status of myoclonic convulsions alternating with generalized tonicoclonic seizures. These states were eliminated by diazepam. The right caudate nucleus was revealed to be more sensitive as compared to the left one to the convulsant action of combined administration of quinolinic acid with penicillin.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002415:Cats; D002421:Caudate Nucleus; D003292:Convulsants; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced; D007267:Injections; D007737:Kynurenine / Q000494:pharmacology*; D008297:Male; D010400:Penicillin G / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000494:pharmacology*; D013997:Time Factors
D003292:Convulsants; D011725:Pyridines; D011805:Quinolinic Acids; D007737:Kynurenine; D017378:Quinolinic Acid; D010400:Penicillin G
Povedencheskie i EEG-priznaki sudorozhnogo deĭstviia kinurenina i khinolinovoĭ kisloty u koshek.