T-immunoblastic lymphoma mimicking B-immunoblastic lymphoma.
A T-cell immunoblastic lymphoma having plasmacytoid features that mimic B-cell immunoblastic lymphoma, is described. The lesion was composed of sheets of pleomorphic plasmacytoid cells that displayed a helper T-cell immunophenotype (Leu-1+, Leu-3+, Leu-4+, Leu-5+, Leu-9-, Leu-2-). Ultrastructural features were consistent with a T-cell lymphoma. Flow cytometric analysis revealed that the cells were DNA triploid and had a high proliferative activity. Although the histology of immunoblastic lymphomas alone may suggest either a T- or B-cell phenotype, immunophenotyping is essential in making this distinction.
D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology*; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005266:Femoral Neoplasms / Q000556:secondary; D005434:Flow Cytometry; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary; D012888:Skull Neoplasms / Q000556:secondary; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014846:Vulvar Neoplasms / Q000175:diagnosis / Q000473:pathology*
D004273:DNA, Neoplasm