DNA repair in lymphocytes from young and old individuals and from patients with Alzheimer's disease.
Lymphocytes from patients with ataxia telangiectasia and Down's syndrome show a greater frequency of chromosome aberrations after ionising radiation than do lymphocytes from normal people. The connection between Down's syndrome and Alzheimer's disease (AD) is well-known. In view of this and of a study showing a greater sensitivity of AD than of normal lymphoblastoid cells to X-irradiation (measured by viability), we have examined repair of AD lymphocytes (hydroxyurea-treated) by measuring [3H]thymidine incorporation after gamma-irradiation. We have found no difference in incorporation between AD and normal lymphocytes from age-matched individuals. However, incorporation decreases with age in gamma-irradiated cells and to a lesser extent in unirradiated cells.
D000328:Adult; D000368:Aged; D000375:Aging; D000544:Alzheimer Disease / Q000235:genetics*; D002470:Cell Survival / Q000528:radiation effects; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair; D005260:Female; D005720:Gamma Rays; D006801:Humans; D006816:Huntington Disease / Q000235:genetics; D006918:Hydroxyurea / Q000494:pharmacology; D008214:Lymphocytes / Q000502:physiology; D008297:Male; D008875:Middle Aged
D004247:DNA; D006918:Hydroxyurea