title: Release of N-terminal peptides from Glu-plasminogen by plasmin in the presence of fibrin.
abstract: The rate of plasmin-catalyzed Glu-plasminogen to Lys-plasminogen conversion was faster in the presence of fibrin than in its absence when assayed by SDS-polyacrylamide gel electrophoresis followed by quantification of stained bands by densitometer. Experiments with the isozymes Glu-plasminogen I and Glu-plasminogen II showed that plasmin-catalyzed formation of Lys-plasminogen II was especially facilitated in the presence of fibrin.
mesh_terms: D004591:Electrophoresis, Polyacrylamide Gel; D005337:Fibrin / Q000494:pharmacology*; D005341:Fibrinolysin / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D007700:Kinetics; D010446:Peptide Fragments / Q000378:metabolism*; D010958:Plasminogen / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D010446:Peptide Fragments; C018998:lysyl-plasminogen; D005337:Fibrin; D010958:Plasminogen; D005341:Fibrinolysin