Action and toxicity of cyclosporine.
Cyclosporine is a potent new immunosuppressive agent that has proven particularly useful in organ transplantation. The unique action of the drug on T-cell immunity without myelosuppression is summarized. Cyclosporine pharmacology and adverse reactions, particularly nephrotoxicity, are reviewed in this paper.
D058186:Acute Kidney Injury / Q000139:chemically induced; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D003524:Cyclosporins / Q000009:adverse effects / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D005885:Gingival Hyperplasia / Q000139:chemically induced; D006084:Graft Rejection; D016027:Heart Transplantation; D006628:Hirsutism / Q000139:chemically induced; D006801:Humans; D007668:Kidney / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced; D016030:Kidney Transplantation; D008099:Liver / Q000187:drug effects; D008223:Lymphoma / Q000139:chemically induced; D009420:Nervous System / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects
D003524:Cyclosporins