[Eradication of hepatitis B in dialysed patients through repeated sero vaccinations].
From December 1981 to April 1984, 56 dialysed patients have been enrolled in a sero-vaccination program in which injections of Hevac B vaccine and anti-HBs immunoglobulin have been repeated to obtain anti-HBs response. Anti-HBs antibodies were distinguished from passively transmitted anti-HBs whenever anti-HBs levels above 33 mUI/ml were found 60 days after the last injection of hepatitis B immune globulins (4 ml). Among 39 patients (25 men, 14 women) (mean age 59 years) the proportion of vaccine responders was 44%, 67%, 82%, 90% after respectively 4, 6, 10, 14 injections of Hevac B vaccine. Age, male sex and duration of dialysis were found to decrease the immune response to the vaccine. Multiple injections and maintenance of protective anti-HBs (titer greater than 20 mUI/ml) can be considered as the most effective method to eradicate HBV infection from dialysis centers.
D000328:Adult; D000368:Aged; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D017325:Hepatitis B Vaccines; D006801:Humans; D007116:Immunization, Passive; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage
D017325:Hepatitis B Vaccines; D014761:Viral Hepatitis Vaccines
Eradication de l'hépatite B chez les dialysés chroniques par séro-vaccinations répétées.