title: Role of macrophages in bypassing the inhibitory activity of Newcastle disease virus on the T-suppressor-cell circuit which regulates contact sensitivity to picryl chloride.
abstract: The interaction between the paramyxovirus of Newcastle disease virus (NDV) and the T-suppressor-cell circuit which regulates the expression phase of contact sensitivity reaction to picryl chloride was investigated. NDV infection impairs the T-acceptor-cell (Tacc) activity, as demonstrated by the failure of Tacc from mice infected with NDV both on Day 0 and on Day 3 to release the nonspecific inhibitor of the passive transfer of contact sensitivity. Tacc from NDV-infected mice fail to bind appreciable amounts of exogenous T suppressor factor, so indicating that the virus eliminates this T-cell population. However, macrophages from mice infected with NDV are able to release a nonspecific inhibitor of the passive transfer of contact sensitivity, indicating that the inhibition of Tacc activity in mice infected with NDV is bypassed by macrophages, so that the T-suppressor circuit is functionally active in NDV-infected mice. The mechanism of the selective inhibition of the Tacc activity by NDV is discussed.
mesh_terms: D000818:Animals; D003877:Dermatitis, Contact / Q000276:immunology*; D007108:Immune Tolerance; D007116:Immunization, Passive; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D009521:Newcastle Disease / Q000276:immunology; D009522:Newcastle disease virus / Q000276:immunology*; D010853:Picryl Chloride; D013154:Spleen / Q000276:immunology; D013491:Suppressor Factors, Immunologic / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D013491:Suppressor Factors, Immunologic; D010853:Picryl Chloride