[Anti-seborrhea effect of cimetidine].
Cimetidine, a histamine H2 antagonist, seems to have anti-androgenic activity. 22 young women were studied during follicular phase prior to and after a 3 month period of treatment with cimetidine (1,200 mg daily). Three month treatment with cimetidine resulted in a significant decrease of seborrheic index (p less than 10(-4)) and casual level (p less than 10(-4)). Testosterone level, TeBG binding capacity and free testosterone were unaffected by the treatment. Cimetidine decrease sebum secretion without change in androgen parameters.
D000152:Acne Vulgaris / Q000188:drug therapy; D000328:Adult; D002927:Cimetidine / Q000627:therapeutic use*; D012628:Dermatitis, Seborrheic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D012867:Skin / Q000032:analysis; D013739:Testosterone / Q000032:analysis
D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D002927:Cimetidine
Effet anti-séborrhéique de la cimétidine.