High content of dietary linoleic acid does not reduce platelet reactivity in patients with hyperlipoproteinaemia.
Seventeen patients with hypertriglyceridaemia were given a lipid-lowering diet with a high P/S-ratio 2.1 during a 3-week period. The very low density lipoprotein triglycerides decreased by 43%, low density lipoprotein cholesterol by 19% and high density lipoprotein cholesterol by 12%. There was a marked increase of linoleic acid (18:2 n-6) in all plasma lipid esters with a concomitant decrease of the saturated and monounsaturated fatty acids. There was a slight increase of the linoleic acid metabolites 18:3 n-6, 20:3 n-6 and 20:4 n-6 in serum triglycerides whereas the fatty acids of the n-3 series decreased in all plasma lipid esters. In the platelets a similar pattern was found with an increase of linoleic acid and its metabolite 22:4 n-6 and a decrease of 18:1 n-9 as well as of the n-3 fatty acids. No significant differences in platelet reactivity was found. However, in a few patients there was an increased platelet aggregation after the diet period. Our results suggest that this diet based on a very high content of linoleic acid may not affect platelet reactivity in a beneficial way. The reason may be an increased turnover of arachidonic acid in the platelets or an imbalance between the n-6 and n-3 series of fatty acids.
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000502:physiology*; D004041:Dietary Fats / Q000008:administration & dosage*; D005227:Fatty Acids / Q000008:administration & dosage / Q000097:blood; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood / Q000178:diet therapy*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D010974:Platelet Aggregation; D001620:beta-Thromboglobulin / Q000378:metabolism
D004041:Dietary Fats; D005227:Fatty Acids; D008041:Linoleic Acids; D008074:Lipoproteins; D010743:Phospholipids; D001620:beta-Thromboglobulin; D019787:Linoleic Acid