title: Effect of insulin excess and deficiency on norepinephrine turnover in rats.
abstract: To examine whether insulin enhances norepinephrine (NE) turnover, an index of sympathetic nerve activity, the effects of excess insulin and streptozotocin (STZ) induced insulin deficiency were examined in Sprague-Dawley rats. Exogenous insulin caused hyperphagia and elevated (approximately 300%) urinary epinephrine excretion, but did not alter cardiac NE content or turnover. STZ-induced insulin deficiency caused hyperglycemia and hyperphagia, but also did not alter cardiac NE content or turnover. Insulin deficiency reduced hepatic NE content 18%, but did not affect NE turnover or content of kidney or spleen. These data do not support the hypothesis that insulin influences cardiac sympathetic nerve activity in rats.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004837:Epinephrine / Q000652:urine; D005260:Female; D007328:Insulin / Q000097:blood / Q000172:deficiency / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013311:Streptozocin; D009638:Norepinephrine; D004837:Epinephrine