Ankyrin-bound fatty acid turns over rapidly at the erythrocyte plasma membrane.
The membrane skeletal protein ankyrin was shown to be continuously acylated and deacylated with long-chain fatty acids in mature erythrocytes. At least a fraction of the lipid bound to ankyrin turned over rapidly (half-life, approximately 50 min) compared with the polypeptide backbone, which was stable throughout the erythrocyte life. This indicates a regulatory significance of the fatty acid modification for the function of ankyrin.
D000818:Animals; D017487:Ankyrins; D001798:Blood Proteins; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood*; D006207:Half-Life; D007700:Kinetics; D008565:Membrane Proteins / Q000097:blood*; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000097:blood; D011817:Rabbits; D014316:Tritium
D017487:Ankyrins; D001798:Blood Proteins; D005227:Fatty Acids; D008565:Membrane Proteins; D010169:Palmitic Acids; D014316:Tritium; D019308:Palmitic Acid