title: Effect of pretreatment with ranitidine on the hypnotic action of single doses of midazolam, temazepam and zopiclone. A clinical study.
abstract: Patients receiving midazolam, temazepam or zopiclone by mouth as premedication for minor gynaecological surgery were pretreated with either ranitidine or an inert tablet. Pretreatment with ranitidine was associated with a greater degree of drowsiness at 20 and 40 min after midazolam, and a shorter mean time to peak hypnotic effect than in the non-pretreated group. Ranitidine did not affect the degree of drowsiness in the patients receiving temazepam or zopiclone.
mesh_terms: D000293:Adolescent; D000328:Adult; D053961:Azabicyclo Compounds; D001569:Benzodiazepines / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008874:Midazolam; D008875:Middle Aged; D010879:Piperazines / Q000494:pharmacology; D011229:Preanesthetic Medication; D011899:Ranitidine / Q000494:pharmacology*; D013693:Temazepam / Q000494:pharmacology; D013997:Time Factors
chemical_list: D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone; D001569:Benzodiazepines; D011899:Ranitidine; D013693:Temazepam; D008874:Midazolam