Inhibition of lymphocyte mitogenesis in mice infected with Newcastle disease virus: viral interference with the interleukin system.
Spleen cells from mice infected with Newcastle disease virus (NDV) fail to proliferate when cultured with allogeneic cells or with concanavalin A (Con A). This failure is not due to impairment of interleukin-1 (IL-1) production or to a lack of accessory cell function as stimulator cells from NDV-infected mice induce DNA synthesis in the mixed lymphocyte reaction. However, spleen cells from NDV-infected mice fail to produce detectable amounts of interleukin-2 (IL-2) when stimulated with mitogenic doses of Con A and do not respond to exogenous IL-2-containing preparations. Furthermore, absorption experiments suggest that cells from NDV-infected mice fail to bind appreciable amounts of exogenous IL-2. All these events seem to be infection-dependent, as cells from mice injected with ultraviolet-inactivated NDV (UV-NDV) behave normally.
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D007108:Immune Tolerance; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis / Q000276:immunology*; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D009521:Newcastle Disease / Q000276:immunology*; D009522:Newcastle disease virus / Q000276:immunology; D013154:Spleen / Q000276:immunology
D000956:Antigens, Viral; D007375:Interleukin-1; D007376:Interleukin-2