Synthesis and degradation of erythrocyte metallothionein in cadmium-administered mice.
The origin of erythrocyte metallothionein (MT) in cadmium (Cd) administered mice and its fate were studied in connection with erythrocyte kinetics. It was shown that Cd-MT in the erythrocyte is synthesized in the precursor cells of the erythropoietic tissues, and Cd-MT containing erythrocytes come into the circulation after maturation. In regard to the degradation, it was found that Cd-MT is stable in the erythrocyte, but decomposed in the spleen or liver with the breakdown of erythrocyte when its life span is over.
D000818:Animals; D002104:Cadmium / Q000493:pharmacokinetics / Q000494:pharmacology*; D002106:Cadmium Radioisotopes; D002850:Chromatography, Gel; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D004920:Erythropoiesis; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D008668:Metallothionein / Q000097:blood* / Q000378:metabolism; D051379:Mice; D013154:Spleen / Q000187:drug effects / Q000378:metabolism
D002106:Cadmium Radioisotopes; C004203:cadmium-binding protein; D002104:Cadmium; D008668:Metallothionein