Foetal macrosomia in diabetic pregnancy. Further data on the association with maternal PGM1 genotype.
The pattern of associations between maternal phosphoglucomutase locus 1 (PGM1) and foetal macrosomia in diabetic pregnancy has been compared with that observed in normal pregnancy. In diabetic pregnancy a substantial increase of macrosomic infants, as compared to normal pregnancy, is observed only among women homozygous for PGM1(1) allele. Also neonatal hypoglycemia is much more frequent in newborns from PGM1(-1) mothers than in newborns from other mothers. Since enzymatic activity of PGM1(-1) phenotype is lower as compared to other PGM1 phenotypes, this may influence glycaemic level and/or its stability in diabetic pregnant women with unfavourable effects on the metabolic and developmental patterns of the foetus.
D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000235:genetics; D005260:Female; D005320:Fetal Macrosomia / Q000209:etiology* / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D010733:Phosphoglucomutase / Q000235:genetics*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000201:enzymology / Q000235:genetics*
D010733:Phosphoglucomutase