No change in neostriatal D-2 dopamine receptors after NMDA lesions of rat prefrontal cortex.
D-2 dopamine receptor function in rat nucleus accumbens and anterior corpus striatum was examined 6-8 days following N-methyl-D-aspartate lesions confined to medial prefrontal cortex. Lesions failed to alter the affinity or density of D-2 receptors labelled by [3H]spiperone in membrane preparations of both subcortical areas. Locomotor activity and stereotyped behaviours induced by the D-2 agonist, LY-171555, were also not significantly altered in lesioned animals. These results suggest that D-2 dopamine receptors of nucleus accumbens and anterior corpus striatum are not localized on corticofugal afferents from medial prefrontal cortex.
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D003342:Corpus Striatum / Q000032:analysis*; D004873:Ergolines / Q000494:pharmacology; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects*; D008297:Male; D016202:N-Methylaspartate; D019257:Quinpirole; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000032:analysis* / Q000187:drug effects; D017448:Receptors, Dopamine D2; D013134:Spiperone / Q000378:metabolism; D014316:Tritium
D004873:Ergolines; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D014316:Tritium; D019257:Quinpirole; D001224:Aspartic Acid; D013134:Spiperone; D016202:N-Methylaspartate