title: Detection of brain autoantibodies in the serum of patients with Alzheimer's disease but not Down's syndrome.
abstract: The immunofluorescent staining of antibodies specifically binding to rat brain tissue sections was investigated in 95 human sera including 30 cases of Alzheimer's disease. A high incidence of specific antibrain antibody was found among Alzheimer's patients (57% positive) compared to other neurological disease controls (only 8% positive) or normal young and aged healthy controls (none positive).
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000276:immunology*; D001323:Autoantibodies / Q000302:isolation & purification*; D001921:Brain / Q000276:immunology*; D004314:Down Syndrome / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology; D010300:Parkinson Disease / Q000276:immunology; D012559:Schizophrenia / Q000276:immunology
chemical_list: D001323:Autoantibodies