title: [Action of amsidine on the evolution of lymphocyte cultures and on the structure of human metaphase chromosomes].
abstract: Chromosomic alterations can be observed after the effect of a antimitotic amsidine on metaphases of cultured human lymphocytes: gaps, breaks, exchange figures, deletions, rings. Moreover we notice, among these cells, particular lines of big sized lymphoplasmocytoid cells, whose rate is abnormally high when compared to reference cultures.
mesh_terms: D000677:Amsacrine / Q000494:pharmacology*; D002478:Cells, Cultured; D002877:Chromosomes, Human / Q000187:drug effects / Q000648:ultrastructure*; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects; D008677:Metaphase / Q000187:drug effects
chemical_list: D000677:Amsacrine
vernacular_title: Action de l'amsidine sur l'évolution de cultures lymphocytaires et sur la structure des chromosomes métaphasiques humains.