Behavioural evidence for the functionality of D-2 but not D-1 dopamine receptors at multiple brain sites in the 6-hydroxydopamine-lesioned rat.
Lisuride (D-2 agonist) and SKF 38393 (D-1 agonist) evoked characteristic circling and stereotyped orofacial movements when administered systemically or stereotaxically into the supersensitive caudate nucleus of unilaterally 6-hydroxydopamine-lesioned rats, which were respectively blocked by D-2 and D-1 antagonists. Lisuride induced similar behaviours from the accumbens, frontal cortex, pallidum, ventromedial thalamus, substantia nigra and periaqueductal grey, while SKF 38393 did not. Multiple brain sites may mediate D-2-induced (not D-1) behaviours following treatment with 6-hydroxydopamine.
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001552:Benzazepines / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D006892:Hydroxydopamines; D008090:Lisuride / Q000494:pharmacology; D008787:Metoclopramide / Q000494:pharmacology; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D013239:Stereotyped Behavior / Q000187:drug effects
D001552:Benzazepines; D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D016627:Oxidopamine; D008090:Lisuride; D008787:Metoclopramide