[Unstable stenocardia: indicators of platelet activity and the effect of verapamil].
Beta-thromboglobin (BTG) and 4 platelet factor (4PF) blood concentration reflecting platelet functional state were determined by radioimmunoassay in 17 patients with unstable angina pectoris, in 18 patients with severe stable angina pectoris (IV functional class) and in 6 healthy subjects. Patients with unstable angina pectoris exhibited signs of platelet activation, i.e significant increase in blood BTG and 4PF concentration, which made qualitative difference from the patients with severe but stable form of the disease. The study of platelet activity at the peak of pain attack has demonstrated further increase in BTG and 4PF concentration in 6 patients having high initial characteristics. In 12 patients with unstable angina pectoris verapamil effect on the platelet functional activity was studied, they exhibited a decrease in BTG and 4PF concentration by intravenous injections as well as by long-term oral administration.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood*; D000789:Angina, Unstable / Q000097:blood* / Q000188:drug therapy; D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000032:analysis; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors; D010978:Platelet Factor 4 / Q000032:analysis; D014700:Verapamil / Q000627:therapeutic use*; D001620:beta-Thromboglobulin / Q000032:analysis
D010446:Peptide Fragments; D010975:Platelet Aggregation Inhibitors; D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; C044557:platelet factor 4 (59-70); D014700:Verapamil
Nestabil'naia stenokardiia: pokazateli, kharakterizuiushchie aktivnost' trombotsitov i vliianie na nikh verapamila.