Antigen-specific, MHC nonrestricted T helper cell-induced B cell activation.
We used a cloned, TNP-specific, MHC-restricted, human Th cell line, E-11, and an assay of cognate Th-B cell interaction, BLAST-2 antigen expression on the B cell surface, to investigate the functional nature of the Th cell antigen receptor. We observed that E-11 induces BLAST-2 expression by resting B cells in a hapten-dependent, hapten-specific, but MHC nonrestricted manner. The implication of these results for the Th cell receptor are discussed.
D000944:Antigens, Differentiation, B-Lymphocyte; D000954:Antigens, Surface / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D006681:HLA-D Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D014301:Trinitrobenzenes / Q000276:immunology
D000944:Antigens, Differentiation, B-Lymphocyte; D000954:Antigens, Surface; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D011948:Receptors, Antigen, T-Cell; D014301:Trinitrobenzenes