Drosophila position-specific antigens resemble the vertebrate fibronectin-receptor family.
The Drosophila position-specific (PS) antigens are a family of cell surface glycoprotein complexes thought to be involved in morphogenesis. Their overall structures and biochemical properties are similar to those of a group of vertebrate receptors, including those for fibronectin, fibrinogen and vitronectin, and also the leukocyte antigens Mac-1, LFA-1 and p150,95 and the VLA family of cell surface antigens. The N-terminal sequences of the alpha subunits of some of these molecules are homologous to the N-terminus of a PS antigen component. The Drosophila PS antigens thus appear to be homologous to these vertebrate receptors.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D002460:Cell Line; D002918:Chymotrypsin; D003488:Cyanogen Bromide; D004331:Drosophila melanogaster / Q000235:genetics*; D005353:Fibronectins / Q000032:analysis; D010446:Peptide Fragments / Q000032:analysis; D017469:Receptors, Fibronectin; D011971:Receptors, Immunologic / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014714:Vertebrates
D000954:Antigens, Surface; D005353:Fibronectins; D010446:Peptide Fragments; D017469:Receptors, Fibronectin; D011971:Receptors, Immunologic; D002918:Chymotrypsin; D003488:Cyanogen Bromide