Behavioral effects of cholecystokinin and its related peptides in rats.
Behavioral effects of cholecystokinin (CCK) were observed in neofrontal decorticated and sham-operated rats. In the decorticated rats the cataleptic and analgesic effects of beta-endorphin were markedly enhanced. When CCK-antiserum was administered together with beta-endorphin, these effects were also enhanced. Sulfated CCK-8 decreased locomotion and rearing in open field test. Proglumide, a selective antagonist of CCK, blocked CCK-8-induced-hypomotility, but it had no influence on the actions of CCK-4. When general activity was monitored using an Automex, the activity counts markedly increased in the decorticated rats, while in the sham-operated rats such increase was not observed. Non-sulfated CCK-8 also stimulated the motility, particularly in the decorticated rats. On the other hand, CCK-4 was opposite to the results of CCK-8. In the decorticated rats rearing, sniffing and head stereotypy were increased by CCK-8, but grooming was not affected.
D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004723:Endorphins / Q000494:pharmacology*; D005755:Gastrins / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011377:Proglumide / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012844:Sincalide / Q000008:administration & dosage / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013758:Tetragastrin / Q000008:administration & dosage / Q000494:pharmacology*; D001615:beta-Endorphin
D004723:Endorphins; D005755:Gastrins; D013758:Tetragastrin; D001615:beta-Endorphin; D011377:Proglumide; D012844:Sincalide