Quantitative study of the migration of lymphocyte subsets through 3-D collagen gels.
Migratory properties of normal peripheral blood lymphocyte subsets were studied with a 3-D collagen gel model. Both the T and B subsets entered the gel at the same rate, but once inside the T subsets migrated significantly faster than the B subsets. In the T subsets, both the T-helper and T-suppressor cells entered the gel at the same rate, but the former migrated significantly faster once inside the gel. The biological significance of their migrations is discussed.
D001402:B-Lymphocytes / Q000145:classification / Q000502:physiology; D002465:Cell Movement / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology*; D005109:Extracellular Matrix; D006801:Humans; D008214:Lymphocytes / Q000145:classification* / Q000502:physiology; D013601:T-Lymphocytes / Q000145:classification / Q000502:physiology; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology
D003094:Collagen