title: Disability in essential tremor: effect of treatment.
abstract: We studied 18 patients with essential tremor for difficulty with handwriting, drinking, eating, fine manipulations, and embarrassment. Propranolol and primidone reduced the amplitude of both postural and kinetic tremor. Handwriting, drinking, and eating were improved with therapy, but fine manipulations and motor performance on tapping and pegboard tests were unaltered. Embarrassment remained unchanged. Essential tremor is not a benign condition; disability can be only partly reversed with drug therapy.
mesh_terms: D000368:Aged; D006233:Persons with Disabilities; D004359:Drug Therapy, Combination; D006225:Hand; D006257:Head; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000187:drug effects; D011324:Primidone / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D011897:Random Allocation; D014202:Tremor / Q000188:drug therapy / Q000503:physiopathology*; D014831:Voice
chemical_list: D011324:Primidone; D011433:Propranolol