title: Assessment of blood flow in the small intestine with laser Doppler flowmetry.
abstract: Blood flow in the small intestine was assessed in 48 patients by laser Doppler flowmetry. Mucosal and serosal flowmeter signals were compared during 'resting' conditions, vascular occlusion, and reactive hyperemia. Serosal flowmeter recordings were compared with the total blood flow of a bowel segment as measured by venous collection. The magnitudes of the mucosal (n = 49) and serosal (n = 49) flowmeter signals were comparable throughout the whole range of flowmeter signals (r = 0.97; p less than 0.001). A correlation coefficient of 0.95 (n = 51; p less than 0.001) was obtained between serosal flowmeter signals and total blood flow during 'resting' and reduced blood flows. During vasodilatation after a vascular occlusion, blood flow was underestimated by the flowmeter. A calibration curve could be constructed for approximate interpretation of the flowmeter signals in absolute flow units. The present study underlines the potential of laser Doppler flowmetry in the assessment of blood flow in the human small intestine.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006801:Humans; D007082:Ileum / Q000098:blood supply; D007413:Intestinal Mucosa / Q000098:blood supply; D007421:Intestine, Small / Q000098:blood supply*; D007583:Jejunum / Q000098:blood supply; D007834:Lasers; D008875:Middle Aged; D012039:Regional Blood Flow; D012212:Rheology