Inhibition of suppressor T lymphocytes (Ts) by cimetidine.
Cyclophosphamide (CY) is the most extensively studied inhibitor of suppressor T lymphocyte (Ts) function. However, repeated administration of CY can abrogate sensitization. Therefore, we were interested in identifying noncytotoxic inhibitors of Ts function as adjuncts in the immunotherapy of Ts-inducing murine tumors. The effect of cimetidine (a histamine type 2 receptor antagonist) and diphenhydramine (a histamine type 1 receptor antagonist) on the Ts mediating tolerance to 2,4-dinitrofluorobenzene was studied. We report our data regarding the specific inhibition of Ts by cimetidine.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D002927:Cimetidine / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology; D004139:Dinitrofluorobenzene / Q000276:immunology; D004155:Diphenhydramine / Q000494:pharmacology; D007108:Immune Tolerance / Q000187:drug effects*; D007116:Immunization, Passive; D051379:Mice; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology
D000954:Antigens, Surface; D002927:Cimetidine; D004155:Diphenhydramine; D003520:Cyclophosphamide; D004139:Dinitrofluorobenzene