title: Repeating sequence homologies in the p36 target protein of retroviral protein kinases and lipocortin, the p37 inhibitor of phospholipase A2.
abstract: Although considerable information has emerged on the molecular properties of the p36 target protein its function as well as the possible implications of its tyrosine phosphorylation have remained elusive. Here we show that all sequence segments of p36 published so far can be aligned by homology along the complete sequence of lipocortin, which has been reported recently. This alignment extends beyond multiple Geisow motifs, thought to indicate a sequence principle implicated in Ca2+ and/or lipid binding. While the latter properties are already established for p36 one may expect them also for lipocortin, an inhibitor of phospholipase A2 activity. Certain implications of these results are discussed.
mesh_terms: D017302:Annexins; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins; D006023:Glycoproteins; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D010750:Phosphoproteins; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D012190:Retroviridae / Q000201:enzymology*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D017302:Annexins; D002135:Calcium-Binding Proteins; D006023:Glycoproteins; D010750:Phosphoproteins; D011505:Protein-Tyrosine Kinases; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; D002118:Calcium