title: Characteristics of the labile neurotoxin associated with nervous coccidiosis.
abstract: Reported are the results of preliminary attempts to characterize the molecular weight, heat sensitivity and other features of a labile neurotoxin identified in the serum of calves exhibiting neurological signs in association with coccidial enteritis. The labile neurotoxin activity is heat labile (60 degrees C for 30 min) and is lost upon exposure to acidic pH (5.5) and cysteine (1.75 g/100 mL serum). Activity can be recovered from the precipitate of a 30% wt/vol solution of (NH4)2SO4 in serum. Ultrafiltration trials suggest that labile neurotoxin activity may be linked to a molecule of over 300,000 MW.
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood*; D005591:Chemical Fractionation; D002850:Chromatography, Gel; D003048:Coccidiosis / Q000097:blood / Q000150:complications / Q000662:veterinary*; D005260:Female; D006358:Hot Temperature; D051379:Mice; D008970:Molecular Weight; D009422:Nervous System Diseases / Q000209:etiology / Q000662:veterinary*; D009498:Neurotoxins / Q000032:analysis* / Q000097:blood; D013047:Specific Pathogen-Free Organisms; D014462:Ultrafiltration
chemical_list: D009498:Neurotoxins