[Free radicals derived from oxygen and lipid peroxidation. Role in cellular biology and physiopathology].
Lipid peroxidation results from the attack of membrane phospholipids by free radicals derived from oxygen. It plays a major role in normal cell life processes. Under physiological conditions, this attack is modulated by an enzymatic system (superoxide dismutase, catalase, glutathione peroxidase) and by a non-enzymatic system (vitamin E and others). Many pathological processes might be explained by a deficient protection system or by an imbalance between attack and protection. Lipid peroxidation is difficult to detect and measure, and the methods available still have low sensitivity.
D000818:Animals; D005609:Free Radicals; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism / Q000502:physiology*; D008563:Membrane Lipids / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism* / Q000502:physiology; D010743:Phospholipids / Q000378:metabolism*
D005609:Free Radicals; D008054:Lipid Peroxides; D008563:Membrane Lipids; D010743:Phospholipids; D010100:Oxygen
Les radicaux libres dérivés de l'oxygène et la peroxydation lipidique. Rôle en biologie cellulaire et en physiopathologie.