[Mutagen sensitivity and the repair process of the lymphocytes in the Werner syndrome].
In this study, we analyzed the cell cycle kinetics, the radiosensitivity, the repair process and the induction of sister chromatid exchanges in lymphocytes from the Werner's syndrome. When compared to a normal population, no statistical significant differences were observed for the cell cycle kinetics and the radiosensitivity. However, differences exist with respect to the repair process and lymphocytes from the Werner's syndrome are much more sensitive to the induction of SCE's.
D000328:Adult; D002453:Cell Cycle; D002478:Cells, Cultured; D003561:Cytarabine / Q000494:pharmacology; D004260:DNA Repair; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D009153:Mutagens / Q000494:pharmacology; D009154:Mutation; D012854:Sister Chromatid Exchange; D014898:Werner Syndrome / Q000235:genetics*
D009153:Mutagens; D003561:Cytarabine
Etude de la sensibilité aux mutagènes et du processus de réparation dans les lymphocytes du syndrome de Werner.