Effect of potassium gluconate on potassium transport of rat erythrocytes.
Effect of potassium gluconate (K-GL) on K+ uptake of rat erythrocytes was investigated. K-GL produced a significant increase in active K+ transport of Na+-rich erythrocytes, while Na+,K+-ATPase activity of hemoglobin-free ghosts without a glycolytic system was unaffected. When the experiment was carried out in intact erythrocytes, K-GL increased the lactate production and ATP content, and it promoted the methemoglobin reduction rate. In Na+-rich erythrocytes, the glycolysis inhibitors which produced a marked reduction in lactate content abolished the K-GL-induced increase in K+ and ATP content without affecting the KCl-induced increase. These results suggest that K-GL enhances K+ transport of erythrocytes through acceleration of glycolytic process.
D000251:Adenosine Triphosphatases / Q000097:blood; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001711:Biotransformation; D004910:Erythrocyte Membrane / Q000201:enzymology; D004912:Erythrocytes / Q000378:metabolism*; D005942:Gluconates / Q000494:pharmacology*; D006019:Glycolysis / Q000187:drug effects; D066298:In Vitro Techniques; D007773:Lactates / Q000096:biosynthesis; D008706:Methemoglobin / Q000378:metabolism; D011188:Potassium / Q000097:blood*; D051381:Rats; D012964:Sodium / Q000097:blood
D005942:Gluconates; D007773:Lactates; D008706:Methemoglobin; D012964:Sodium; D000251:Adenosine Triphosphatases; C030691:gluconic acid; D011188:Potassium