[Attenuation of protein-nuclein interactions induced by chemical mutagens in a human fibroblast culture].
Using nucleoprotein celite chromatography, it has been shown that DNA of human cultured fibroblasts was strongly bound to the proteins of the nuclear matrix. N-methyl-N-nitrosourea and prospidin-active antitumor agents with marked mutagenic action--were shown to attenuate the interactions, which appeared to be partially sensitive in cultured fibroblasts from patients with Down's syndrome.
D000970:Antineoplastic Agents / Q000494:pharmacology; D002845:Chromatography; D004247:DNA / Q000378:metabolism*; D004314:Down Syndrome / Q000235:genetics / Q000378:metabolism; D005347:Fibroblasts; D006801:Humans; D066298:In Vitro Techniques; D008770:Methylnitrosourea / Q000494:pharmacology; D009153:Mutagens; D009687:Nuclear Proteins / Q000378:metabolism*; D011447:Prospidium / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects
D000970:Antineoplastic Agents; D009153:Mutagens; D009687:Nuclear Proteins; D008770:Methylnitrosourea; D011447:Prospidium; D004247:DNA
Oslablenie belkovo-nukleinovykh vzaimodeĭstviĭ, indutsirovannoe nekotorykh khimicheskimi mutagenami v kul'ture fibroblastov cheloveka.