[Immune adherence (C3b) receptor activity of erythrocytes in patients with esophageal cancer and cancer of the gastric cardia].
The red cell C3b receptor activity of 52 patients with esophageal cancer, 19 patients with cancer of gastric cardia and 31 age-matched normal persons was studied by the ability of forming ZC3b-rosette (rosette formation with zymosan particles treated by guinea pig complement) and IC-Z rosette (rosette formation with zymosan particles). The results showed that the ZC3b-rosette formation rate was significantly lower in cancer patients than that of the normal subjects (P less than 0.01), but the IC-Z rosette formation rate was significantly higher in the cancer patients (P less than 0.01). This suggests that the esophageal cancer and cancer of gastric cardia be associated with surface changes in the erythrocytes, especially those of the receptors which are responsible for immune adherence reaction. The methods of detecting the red cell C3b receptor are also described.
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis; D002299:Cardia; D003180:Complement C3b Inactivator Proteins / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D004938:Esophageal Neoplasms / Q000276:immunology*; D005260:Female; D006801:Humans; D007104:Immune Adherence Reaction; D008297:Male; D008875:Middle Aged; D011951:Receptors, Complement / Q000276:immunology*; D017463:Receptors, Complement 3b; D012397:Rosette Formation / Q000379:methods; D013274:Stomach Neoplasms / Q000276:immunology*
D000936:Antigen-Antibody Complex; D003180:Complement C3b Inactivator Proteins; D011951:Receptors, Complement; D017463:Receptors, Complement 3b