title: Intracellular turnover and cardiac hypertrophy.
abstract: Ultrastructural evidence is presented that intracellular autophagic degradation of cytoplasmic constituents is reduced during pressure induced hypertrophy of left ventricular myocardium after supravalvular aortic constriction in rats. This anti-catabolic reaction has to be considered as an important mechanism for shifting the balance between synthesis and degradation to the positive side. Short term studies after administration of isoproterenol suggest a close functional relationship between work load on the one hand and the anti-catabolic reaction on the other.
mesh_terms: D000818:Animals; D001343:Autophagy; D006332:Cardiomegaly / Q000378:metabolism / Q000473:pathology*; D006321:Heart / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008854:Microscopy, Electron; D010587:Phagocytosis; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011506:Proteins; D007545:Isoproterenol