title: Induction of ovulation in anoestrous mares with a slow-release implant of a GnRH analogue (ICI 118 630).
abstract: A total of 18 experimental pony and 136 commercial maiden, barren and foaling Thoroughbred mares in seasonal or lactation-related anoestrus were injected subcutaneously with 1 or 2 slow-release D,L-lactide-glycolide co-polymer implants impregnated with 0.9 or 1.8 mg of the potent GnRH analogue, ICI 118 630, to give a daily release of, respectively, 30 or 60 micrograms analogue for 28 days; 32 of the Thoroughbred mares were also given a daily oral dose of 27.5 mg allyl trenbolone for 5 days after injection of the implant. Thirteen pony (76%) and 120 Thoroughbred (88%) mares ovulated 3-18 days after treatment with ICI 118 630 and the additional treatment with allyl trenbolone did not significantly reduce the considerable variation in the interval between treatment with GnRH analogue and ovulation. Of 100 Thoroughbred mares mated during the GnRH analogue-induced oestrus, (70%) conceived. The results of this trial demonstrated that low-dose, slow-release formulations of GnRH agonists have considerable potential as a practical method of hastening renewed ovarian cyclicity in anoestrous mares.
mesh_terms: D000780:Anestrus / Q000187:drug effects*; D000818:Animals; D002064:Buserelin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004343:Drug Implants; D004971:Estrus / Q000187:drug effects*; D005260:Female; D017273:Goserelin; D006736:Horses / Q000502:physiology*; D010062:Ovulation Induction / Q000379:methods / Q000662:veterinary*; D045167:Progesterone Congeners / Q000494:pharmacology; D014204:Trenbolone Acetate / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D004343:Drug Implants; D045167:Progesterone Congeners; D017273:Goserelin; C023445:altrenogest; D002064:Buserelin; D014204:Trenbolone Acetate