title: [Biological aspects of chronic lymphoid leukemia].
abstract: The present study is concerned with clinical prognostic classifications of chronic lymphocytic leukemia derived from numerous statistics and multivariate survival analysis. We analyse the prognostic significance of some biological patterns: bone marrow histological studies, lymph node biopsies, size, structure and doubling time of blood lymphocytes, tumoral markers and karyotype analysis. The problem of the monoclonal clone origin is discussed: differentiation abnormality or proliferation of a physiological clone.
mesh_terms: D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000145:classification / Q000473:pathology / Q000503:physiopathology*; D007958:Leukocyte Count; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
vernacular_title: Aspects biologiques de la leucémie lymphoïde chronique.