title: Topical corticosteroid therapy for children: alclometasone dipropionate cream 0.05%.
abstract: The safety and efficacy of twice-daily applications of alclometasone dipropionate cream 0.05% were evaluated in 39 children with eczema during a three-week open study. Early-morning plasma cortisol levels were monitored at weekly intervals (visits 1, 2, and 3) for six children. For the remaining 33 children, levels were measured at visits 1 and 2 and two weeks later, at visit 4. Improvement in signs and symptoms of erythema, induration, and pruritus and a global response to therapy were determined weekly. Plasma cortisol levels remained within the acceptable normal range of 7 to 25 micrograms/100 ml throughout the study in all 39 children. At the conclusion of treatment, a favorable global response--complete clearing of monitored signs and symptoms--was observed in 28 (72%) children, and marked or moderate improvement was recorded for seven (18%) children.
mesh_terms: D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000188:drug therapy; D012628:Dermatitis, Seborrheic / Q000188:drug therapy; D003963:Diaper Rash / Q000188:drug therapy; D004341:Drug Evaluation; D004485:Eczema / Q000097:blood / Q000188:drug therapy*; D004890:Erythema / Q000188:drug therapy; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007223:Infant; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D011537:Pruritus / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; C021137:alclometasone dipropionate; D006854:Hydrocortisone; D008775:Methylprednisolone