Adverse reaction to sulphonamides in a burned patient--a case report.
This is a case report of a patient who developed severe drug eruptions suspected to have been caused by sulphamethoxazole-trimethoprim (ST) administered orally for the treatment of urinary infection after burn injury. He had been treated topically with silver sulphadiazine (AgSD) after injury. The immunological examinations revealed positive reactions to both drugs, so that it is surmised that AgSD created the sensitivity and might be concerned in these drug eruptions. For such reasons, it is advisable, especially in patients who have been previously treated with topical or oral sulphonamides or have had episodes of hypersensitivity to such drugs, to administer sulphonamides carefully, or if possible to avoid administration.
D000328:Adult; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects*; D002056:Burns / Q000150:complications*; D004338:Drug Combinations / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D010328:Patch Tests; D012837:Silver Sulfadiazine / Q000009:adverse effects* / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy; D013411:Sulfadiazine / Q000009:adverse effects*; D013420:Sulfamethoxazole / Q000009:adverse effects*; D013449:Sulfonamides / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014552:Urinary Tract Infections / Q000209:etiology
D000892:Anti-Infective Agents, Urinary; D004338:Drug Combinations; D013449:Sulfonamides; D013411:Sulfadiazine; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole; D012837:Silver Sulfadiazine