[Effect of antigen-induced B-suppressors on the development of B memory cells, carrier-specific T-helpers and antibody-producing cells].
(CBA X C57BL/6)F1 mice were immunized with 5 X 10(7) sheep red blood cells (SRBC). Seven days later plastic non-adherent B cells were prepared from spleens. They were designated as antigen-induced B-suppressors (AIBs). In double syngeneic transfer system AIBs stimulated the development of memory B cells (Bm) and suppressed the development of carrier-specific helper T cells (Th) and antibody-forming cells (AFC). AIBs possessing a surface Fc-receptor for human serum IgG (FcR+) inhibited the formation of all these cells. FcR- -AIBs failed to affect the development of Th and AFC, but stimulated the formation of Bm. In vitro preincubation of FcR+ -AIBs with mitomycin C or in vivo irradiation with 8 Gy abrogated the inhibitory effect on Bm and Th, but not AFC. It is suggested that FcR+ -AIBs suppress proliferation of Bm, Th and AFC precursors.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D007156:Immunologic Memory; D008297:Male; D051379:Mice; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
Vliianie antigenindutsirovannykh B-suppressorov na razvitie B-kletok pamiati, spetsificheskykh k nositel'iu T-khelperov i antiteloobrazuiushchikh kletok.