title: Dipyridamole-induced myocardial ischemia.
abstract: Angina and ischemic electrocardiographic changes occurred after administration of oral dipyridamole in four patients awaiting urgent myocardial revascularization procedures. To our knowledge, this has not previously been reported as a side effect of preoperative dipyridamole therapy, although dipyridamole-induced myocardial ischemia has been demonstrated to occur in animals and humans with coronary artery disease. Epicardial coronary collateral vessels were demonstrated in all four patients; a coronary "steal" phenomenon may be the mechanism of the dipyridamole-induced ischemia observed.
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000503:physiopathology*; D000789:Angina, Unstable / Q000503:physiopathology*; D000800:Angioplasty, Balloon; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000139:chemically induced* / Q000628:therapy; D004176:Dipyridamole / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011292:Premedication
chemical_list: D004176:Dipyridamole