[Early cell repair of the lung and the intestine in mice, after irradiation by fast neutrons and gamma rays].
Lung tolerance is assessed from LD50 at 180 days after thoracic irradiation, in mice, with d(50) + Be neutrons and 60Co gamma rays. Early intestinal tolerance is assessed from LD50 at 7 days after abdominal irradiation. Additional dose (Dr) to reach LD50 when a single dose Ds is split into 2 equal fractions Di separated by different time intervals "i", is determined (Dr = 2Di - Ds), Dr is larger after gamma than after neutron irradiation, for lung and intestine. After thoracic irradiation with gamma rays, Dr reaches 3.36, 4.38, 5.12 and 5.37 Gy for "i" = 2, 6, 12 and 24 hours respectively; after neutron irradiation, Dr reaches 0.66, 0.9, 1.29, 1.95 and 1.50 Gy for "i" = 1, 2, 4, 12 and 24 hours. Dr is smaller for intestine; after abdominal irradiation with gamma rays, it reaches 1.99, 2.59, 2.74, 3.11, 3.34, 4.44 and 4.56 Gy for "i" = 1, 2, 3.5, 8, 12, 18 and 24 hours; after neutron irradiation, it reaches 0.13, 0.45, 0.42 and 1.33 Gy for "i" = 1.5, 3.5, 5.5 and 24 hours. After gamma irradiation, early repair is complete after 3.5 hours for intestine and needs 12 hours for lung.
D000005:Abdomen / Q000528:radiation effects; D000818:Animals; D002453:Cell Cycle; D005214:Fast Neutrons / Q000009:adverse effects; D005260:Female; D005720:Gamma Rays; D007422:Intestines / Q000166:cytology / Q000528:radiation effects*; D007928:Lethal Dose 50; D008168:Lung / Q000166:cytology / Q000528:radiation effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013909:Thorax / Q000528:radiation effects; D013997:Time Factors
Réparation cellulaire précoce du poumon et de l'intestin, chez la souris, après irradiation par neutrons rapides et rayons gamma.