Inactivation of phi X174 DNA by the ortho-quinone derivative or its reduction product of the antitumor agent VP 16-213.
Biologically active phi X174 DNA is inactivated by the ortho-quinone derivative of the antitumor agent VP 16-213, but not by VP 16-213 itself, VP 16-213 phenoxy radical or aqueous decomposition product(s) of the ortho-quinone. Reduction of the ortho-quinone by cytochrome P-450 reductase and NADPH results in deactivation of the ortho-quinone towards anti-phi X174 DNA activity. However, compared with the parent compound VP 16-213, reduction of the ortho-quinone results in substantial damage towards DNA.
D010584:Bacteriophage phi X 174 / Q000187:drug effects*; D004277:DNA, Single-Stranded; D004279:DNA, Viral; D005047:Etoposide / Q000031:analogs & derivatives* / Q000494:pharmacology; D009249:NADP / Q000378:metabolism; D011034:Podophyllotoxin / Q000031:analogs & derivatives*
D004277:DNA, Single-Stranded; D004279:DNA, Viral; D009249:NADP; D005047:Etoposide; D011034:Podophyllotoxin