title: Impaired in vivo and in vitro antibody responses to bacteriophage phi X 174 in juvenile rheumatoid arthritis.
abstract: Immunologic abnormalities described in juvenile rheumatoid arthritis (JRA) have been largely confined to mitogen or antigen driven proliferation assays. We studied antigen specific antibody production using the neoantigen bacteriophage phi X 174 in vivo and in vitro; defective responses were found in all 8 patients with JRA studied. These could not be attributed to circulating anti-T cell antibodies, but may relate to lymphocyte subset abnormalities found by 2 color analyses. These immunologic aberrations may play a direct role in the pathogenesis of JRA or, alternatively, may be a secondary event.
mesh_terms: D000293:Adolescent; D000917:Antibody Formation; D000918:Antibody Specificity; D000961:Antilymphocyte Serum / Q000032:analysis; D001171:Arthritis, Juvenile / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D010584:Bacteriophage phi X 174 / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007108:Immune Tolerance; D007376:Interleukin-2 / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000961:Antilymphocyte Serum; D007376:Interleukin-2