Metabolic conversions of trichothecene mycotoxins: biotransformation of 3-acetyldeoxynivalenol into fusarenon-X.
The trichothecene mycotoxin 3-acetyldeoxynivalenol was transformed by cultures of the diacetoxyscirpenol producer Fusarium sp. strain C37410-90 into four compounds, identified as deoxynivalenol, 15-acetyldeoxynivalenol, 3,15-diacetyldeoxynivalenol and fusarenon-X. The major transformations are the result of specific esterification and de-esterification processes, but the production of fusarenon-X involves in addition a novel 4 beta-hydroxylation of the trichothecene ring system itself.
D001711:Biotransformation; D005670:Fusarium / Q000254:growth & development / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000096:biosynthesis* / Q000378:metabolism*; D014255:Trichothecenes / Q000096:biosynthesis* / Q000378:metabolism*
D012717:Sesquiterpenes; D014255:Trichothecenes; C002469:fusarenon-X; C043247:3-acetyldeoxynivalenol