Impaired T-cell-independent B-cell maturation in systemic lupus erythematosus: coculture experiments in monozygotic twins concordant for Klinefelter's syndrome but discordant for systemic lupus erythematosus.
In a case of monozygotic twins discordant for systemic lupus erythematosus (SLE), coculture experiments with isologous (i.e., genetically identical) lymphocytes were performed. Adequate T-helper-cell function in the SLE twin was demonstrated. Lack of B-cell responsiveness to T-cell-dependent and T-cell-independent polyclonal activators points to a T-cell-independent B-cell maturation defect in the SLE twin.
D000293:Adolescent; D001327:Autoimmune Diseases / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D004200:Diseases in Twins / Q000276:immunology*; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications / Q000235:genetics; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000145:classification; D008297:Male; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014430:Twins, Monozygotic