Cardiovascular effects of atrial natriuretic extract in the whole animal.
Atrial tissue extract (AE) and ventricular tissue extract cause identical decreases in total peripheral resistance when they are injected i.v. into anesthetized rats. However, only AE causes significant hypotension because of cardiac inhibition. This involves both bradycardia and failure of stroke volume to increase appropriately. The observations cannot be explained by direct action of AE on myocytes, but are more likely to be the result of interactions with cardiovascular reflex mechanisms. Excitation of chemosensitive cardiac receptors with vagal afferents appears to be an important afferent mechanism. The efferent limb for the negative chronotropic response resides partly in the vagus nerves and partly in cardiac sympathetic nerves. The negative inotropic response of AE was not altered by vagotomy, spinal section, atropine, or propranolol. These results suggest that atrial peptides may cause the release of a negatively inotropic substance from a site that is not yet identified.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D016275:Atrial Function; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects; D002628:Chemoreceptor Cells / Q000502:physiology; D004525:Efferent Pathways / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D008465:Mechanoreceptors / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013318:Stroke Volume / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000502:physiology; D014020:Tissue Extracts / Q000494:pharmacology; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology; D014655:Vascular Resistance; D016276:Ventricular Function
D014020:Tissue Extracts; D001285:Atropine; D009320:Atrial Natriuretic Factor; D011433:Propranolol