Correlation between high-molecular-weight Fc gamma-receptor-blocking factors in serum and renal allograft survival.
In this study, we have demonstrated the occurrence of IgG class noncytotoxic, lymphocyte Fc gamma-receptor-blocking antibodies in a proportion of sera obtained from transfused uremic patients. The presence of these antibodies was not found to correlate with subsequent renal allograft survival. Serum fractionation studies did however reveal a striking correlation between graft survival and Fc gamma-receptor blocking mediated by a serum factor(s) with a sedimentation coefficient of greater than 19S. The precise nature of this factor remains to be clarified.
D001798:Blood Proteins / Q000502:physiology*; D001803:Blood Transfusion; D004137:Dinitrochlorobenzene / Q000276:immunology; D006085:Graft Survival; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007518:Isoantibodies / Q000276:immunology*; D016030:Kidney Transplantation; D008970:Molecular Weight; D011961:Receptors, Fc / Q000276:immunology*; D017452:Receptors, IgG; D012397:Rosette Formation
D001798:Blood Proteins; D004137:Dinitrochlorobenzene; D007518:Isoantibodies; D011961:Receptors, Fc; D017452:Receptors, IgG