Dopaminergic mediation of the diuretic and natriuretic effects of ANF in the rat.
Atrial natriuretic factor (ANF) increases sodium (Na+) and water excretion 8-10 fold on repeated administration to anesthetized rats. SCH-23390 (80 micrograms/kg i.v.) and R-sulpiride (80 micrograms/kg i.v.), selective antagonists of dopamine receptors in the renal vasculature, inhibited diuresis and natriuresis induced by AP III and dopamine. These findings suggest that ANF exerts its effects on renal Na+ and water handling via a dopaminergic mechanism; however, changes in intrarenal hemodynamics secondary to dopamine receptor blockade may attenuate the actions of ANF.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001552:Benzazepines / Q000494:pharmacology; D001794:Blood Pressure; D004231:Diuresis / Q000187:drug effects*; D004298:Dopamine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D007668:Kidney / Q000098:blood supply; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism; D013469:Sulpiride / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects
D001552:Benzazepines; D011954:Receptors, Dopamine; D013469:Sulpiride; D009320:Atrial Natriuretic Factor; D004298:Dopamine