Inhibition of histamine and allergen skin wheal by cetirizine in four animal species.
Histamine-induced skin reactions were studied in four animal species. Cetirizine displayed very potent oral antihistaminic activity in this model. In rats, the dose that reduced the reaction by 50% in comparison to controls was 4.2 mumol/kg and between 0.1 and 0.4 mumol/kg for the other species (mice, guinea pigs, and dogs). Cetirizine also inhibited the immediate hypersensitivity reaction induced by Ascaris extract in dogs. By the oral route, cetirizine had a more potent and longer acting activity than mepyramine, clemastine, terfenadine, astemizole, and hydroxyzine.
D000485:Allergens / Q000276:immunology*; D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology; D017332:Cetirizine; D002974:Clemastine / Q000494:pharmacology; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D006633:Histamine Antagonists / Q000494:pharmacology*; D006919:Hydroxyzine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006969:Hypersensitivity, Immediate / Q000503:physiopathology* / Q000517:prevention & control; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011738:Pyrilamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013045:Species Specificity; D016593:Terfenadine
D000485:Allergens; D001559:Benzhydryl Compounds; D006633:Histamine Antagonists; D006919:Hydroxyzine; D016593:Terfenadine; D006632:Histamine; D002974:Clemastine; D011738:Pyrilamine; D017332:Cetirizine