title: Acute effect of a single infusion of papaverine on human peripheral lymphocyte.
abstract: It has been reported that drugs which modulate the intracellular levels of 3' 5' cyclic adenosinemonophosphate (cAMP) interfere with the cellular function of the immune system. In this work, papaverine, a drug effective in elevating cAMP levels, was observed to increase the T4+/T8+ ratio in vivo. Furthermore, peripheral blood mononuclear cells (PBMC) from young healthy volunteers who received intravenous papaverine (3 mg/kg i.v. over 15 min) showed a decreased response in allogenic mixed lymphocyte reaction (MLR) but a normal behaviour in a polyclonal mitogen assay and in autologous MLR (AMLR). These findings suggest that papaverine administration could influence the immune system functions.
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D006801:Humans; D007263:Infusions, Parenteral; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000145:classification / Q000187:drug effects* / Q000276:immunology; D010208:Papaverine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000911:Antibodies, Monoclonal; D010208:Papaverine