Papillon-Lefèvre syndrome. Report of two patients treated successfully with isotretinoin.
The Papillon-Lefèvre syndrome is an autosomal recessive disorder characterized by diffuse palmoplantar keratoderma and premature loss of both the deciduous and the permanent teeth. We report two female patients with Papillon-Lefèvre syndrome in whom treatment with oral isotretinoin produced remarkable improvement of the keratoderma within 2 weeks.
D000328:Adult; D005260:Female; D006801:Humans; D015474:Isotretinoin; D007645:Keratoderma, Palmoplantar / Q000188:drug therapy*; D010214:Papillon-Lefevre Disease / Q000188:drug therapy* / Q000473:pathology; D014212:Tretinoin / Q000009:adverse effects / Q000627:therapeutic use*
D014212:Tretinoin; D015474:Isotretinoin