Effect of dietary sodium on plasma concentration of immunoreactive atrial natriuretic factor in normal humans.
Atrial natriuretic factor (ANF) is the name applied to a family of peptides secreted by the atria, endowed with potent natriuretic, vasorelaxant, and aldosterone inhibitory properties, and which has been purified from animal and human atria. A radioimmunoassay of human plasma ANF was developed. Six normal men, aged between 24 and 38, were studied after 4 days on a low-sodium diet (40 mmol per day) and 4 days on a high-sodium diet (300 mmol per day), in random order. Plasma renin activity was suppressed and plasma aldosterone reduced by the high-sodium diet, as expected. Plasma immunoreactive ANF was 47.9 +/- 4.8 pg/ml on the low-sodium diet and rose to 68.1 +/- 5.9 pg/ml on the high-sodium diet (p less than 0.01). These results demonstrate that secretion of ANF by the heart may be modulated by the changes produced by extreme variations in sodium intake.
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D004032:Diet; D004039:Diet, Sodium-Restricted; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D011863:Radioimmunoassay; D012964:Sodium / Q000008:administration & dosage* / Q000494:pharmacology
D009320:Atrial Natriuretic Factor; D012964:Sodium