[Inhibitory action of glucocorticoids on the synthesis of prostaglandins].
In most of the cell types hitherto investigated in vitro, glucocorticoids have been shown to decrease the synthesis of prostaglandins and of lipoxygenase derivatives of arachidonic acid. This effect seems to be related to the induction of protein inhibitors of phospholipase A2. Several of these inhibitors, called lipocortins, have recently been identified in leucocytes, macrophages and rat renomedullary cell cultures. However, systemic treatment with glucocorticoids in animals and in man has generally failed to induce a significant decrease in either urinary excretion or plasma concentration of prostaglandins. These results suggest that inhibition of prostaglandin synthesis is not the only mechanism explaining the anti-inflammatory action of glucocorticoids and raise the question of the physiological role of lipocortins.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D011453:Prostaglandins / Q000096:biosynthesis* / Q000378:metabolism; D011817:Rabbits; D051381:Rats
D001095:Arachidonic Acids; D005230:Fatty Acids, Nonesterified; D005938:Glucocorticoids; D011453:Prostaglandins
Action inhibitrice des glucocorticoïdes sur la synthèse de prostaglandines.