Docosahexaenoate-containing phospholipids in sarcoplasmic reticulum and retinal photoreceptors. A proposal for a role in Ca2+-ATPase calcium transport.
A critical review of the experimental literature concerning the metabolism of all-cis-4, 7, 10, 13, 16, 19-docosahexaenoate-containing phospholipids in muscle and retina suggests that it plays an essential role in maximizing the Ca2+/ATP stoichiometry of the Ca2+-ATPase of sarcoplasmic reticulum and retinal photoreceptor disks. Docosahexaenoate-phosphatidylcholine is proposed to participate in oligomerization of Ca2+-ATPase necessary for the establishment of a high Ca2+/ATP coupling ratio of the Ca2+ pump in these tissues. Possible tests of this hypothesis are presented.
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D004281:Docosahexaenoic Acids; D005231:Fatty Acids, Unsaturated / Q000502:physiology*; D008563:Membrane Lipids / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology; D010713:Phosphatidylcholines / Q000502:physiology; D010743:Phospholipids / Q000502:physiology*; D010786:Photoreceptor Cells / Q000502:physiology*; D012160:Retina / Q000502:physiology; D012374:Rod Cell Outer Segment / Q000502:physiology; D012519:Sarcoplasmic Reticulum / Q000502:physiology*
D005231:Fatty Acids, Unsaturated; D008563:Membrane Lipids; D010713:Phosphatidylcholines; D010743:Phospholipids; D004281:Docosahexaenoic Acids; D000252:Calcium-Transporting ATPases