Beta-endorphin-(1-27) antagonizes beta-endorphin-induced hypothermia in mice.
The effects of beta-endorphin and beta-endorphin-(1-27) on the body temperature of mice was studied at an ambient temperature of 10 degrees C. Intracerebroventricular injection of beta-endorphin (0.25-4 micrograms) and beta-endorphin-(1-27) (0.61 to 10 micrograms) caused a dose-related hypothermia. The duration of hypothermia induced by beta-endorphin-(1-27) was shorter than that induced by beta-endorphin. The hypothermia induced by 2 micrograms of beta-endorphin was attenuated by 5 micrograms of beta-endorphin-(1-27). Our results indicated that beta-endorphin-(1-27) is a partial agonist which produces a small degree of hypothermia and an antagonist which blocks the beta-endorphin-induced hypothermia.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004723:Endorphins / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010446:Peptide Fragments / Q000494:pharmacology*; D013997:Time Factors; D001615:beta-Endorphin
D004723:Endorphins; D010446:Peptide Fragments; D001615:beta-Endorphin; C035581:beta-endorphin (1-27)