[Intracoronary thrombolysis or brief intravenous infusion of high-dose streptokinase in the treatment of acute myocardial infarction].
Intracoronary infusions of streptokinase result in recanalization in about 80% of patients treated during the 4 hours following the first symptoms of myocardial infarction. With short, high dose intravenous infusions (streptokinase 1,500,000 units in 30 min) the recanalization rate is of the order of 60-75%. The high dose of streptokinase is well tolerated, and the intravenous infusion presents the advantage of shortening by about 2 hours the delay required to start intracoronary administration.
D000818:Animals; D003331:Coronary Vessels; D006801:Humans; D007263:Infusions, Parenteral / Q000009:adverse effects; D009203:Myocardial Infarction / Q000188:drug therapy*; D012008:Recurrence; D013300:Streptokinase / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors
D013300:Streptokinase
Thrombolyse intracoronarienne ou perfusion intraveineuse brève de streptokinase à haute dose pour le traitement de l'infarctus aigu du myocarde.