[Compensatory growth of the kidney. Effects of 3 antihistaminic drugs].
The compensatory growth of the kidney (C. G. K.) in the rat, is accompanied by a lowering of the renal concentration of histamine (507 micrograms/kg 48 hours after the beginning of the C. G. K. against 1,070 micrograms/kg in the normal kidney). Three antihistamines were injected i.p. during the first 48 hours of the C. G. K.: dexchlorpheniramine (H1 antagonist), cimetidine (H2 antagonist) and doxepin (both H1 and H2 antagonist). The C. G. K. was significantly lowered only in the rats that had been treated with doxepin in doses of 0.3 and 1 mg/kg/24 h. None of these treatments altered the histamine concentration in the kidney 48 hours after the beginning of the C. G. K. The action of doxepin might pass through mechanisms other than its anti-histaminic activity.
D000818:Animals; D006632:Histamine / Q000378:metabolism*; D006633:Histamine Antagonists / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D009392:Nephrectomy; D011184:Postoperative Period; D051381:Rats; D011919:Rats, Inbred Strains
D006633:Histamine Antagonists; D006632:Histamine
Croissance compensatrice du rein. Effets de trois antihistaminiques.