title: Alveolar macrophage and its participation in the inflammatory processes of allergic asthma.
abstract: Purified alveolar macrophages (AM) obtained by bronchoalveolar lavage of allergic asthmatic patients are stimulated by incubation with anti IgE or the exposure to the related allergen. Confirming the demonstration of a receptor for the Fc fragment of IgE on the surface of macrophages, IgE was characterised on AMs by a rosette-assay, showing an increased percentage of cells forming rosettes with red blood cells coated with anti-IgE or the specific allergen. The IgE-dependent secretion of arachidonic acid metabolites, PAF-acether and chemotactic factors for neutrophils and eosinophils demonstrated in vitro, together with the in vivo demonstration of the activation of AMs by a local provocation test, suggest that besides mast cell, AM do participate in the inflammatory processes of allergic asthma.
mesh_terms: D000906:Antibodies / Q000276:immunology; D001249:Asthma / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D007114:Immunization; D007073:Immunoglobulin E / Q000276:immunology; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology; D008264:Macrophages / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D009000:Monocytes / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D011961:Receptors, Fc / Q000378:metabolism; D017455:Receptors, IgE; D011971:Receptors, Immunologic / Q000378:metabolism
chemical_list: D000906:Antibodies; D011961:Receptors, Fc; D017455:Receptors, IgE; D011971:Receptors, Immunologic; D007073:Immunoglobulin E; D005966:Glucuronidase