Effects of antineoplastic agents on the cell cycle progression.
Almost all antineoplastic drugs are able to delay--or block--cells in a particular phase of the cell cycle. Few clinically active drugs seem to interact with the G1-states where cell growth can be arrested, although new compounds could be of interest with this respect. In contrast, most antineoplastic agents interact with DNA and/or DNA metabolism and have been shown to provoke a delay in G2. This could be the consequence of the DNA damage or of interference with controls which take place within the G2 phase.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D004247:DNA / Q000187:drug effects; D005434:Flow Cytometry / Q000379:methods; D007399:Interphase / Q000187:drug effects
D000970:Antineoplastic Agents; D004247:DNA