The trans Golgi network: sorting at the exit site of the Golgi complex.
The Golgi complex is a series of membrane compartments through which proteins destined for the plasma membrane, secretory vesicles, and lysosomes move sequentially. A model is proposed whereby these three different classes of proteins are sorted into different vesicles in the last Golgi compartment, the trans Golgi network. This compartment corresponds to a tubular reticulum on the trans side of the Golgi stack, previously called Golgi endoplasmic reticulum lysosomes (GERL).
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D002451:Cell Compartmentation; D004705:Endocytosis; D005089:Exocytosis; D006031:Glycosylation; D006056:Golgi Apparatus / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007425:Intracellular Membranes / Q000502:physiology; D008247:Lysosomes / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism; D017527:Receptor, IGF Type 2
D002352:Carrier Proteins; D008565:Membrane Proteins; D011506:Proteins; D017527:Receptor, IGF Type 2