Gadolinium-DTPA enhancement of experimental soft tissue carcinoma and hemorrhage in magnetic resonance imaging.
An experimental series in the rabbit was performed to test gadolinium-DTPA (Gd-DTPA) enhancement of VX-2 carcinoma and hemorrhages induced in the soft tissues. The recognition of both malignant and benign lesions was greatly facilitated on T1 weighted images after intravenous administration of 0.3 mmol Gd-DTPA/kg body weight because of reduced T1 relaxation times. Gd-DTPA enhancement reached its maximum after 10-15 minutes and was most apparent in tumor tissue, connective tissue surrounding the tumor and in the area of fresh hemorrhage.
D000818:Animals; D003287:Contrast Media; D005682:Gadolinium; D019786:Gadolinium DTPA; D006470:Hemorrhage / Q000175:diagnosis*; D007089:Image Enhancement; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011817:Rabbits; D012983:Soft Tissue Neoplasms / Q000175:diagnosis*
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA