Biochemical studies of acrylamide neuropathy.
Studies on the toxicokinetics and biochemical effects of acrylamide are reviewed in regard to their implications concerning the mechanism of acrylamide induced neuropathy. Specifically, investigations of the effects of acrylamide on several glycolytic enzymes including neuron-specific enolase and glyceraldehyde-3-phosphate dehydrogenase are evaluated. Both of these enzymes are decreased in activity in animals exhibiting clinical signs of neuropathy induced by acrylamide. The significance of these findings in terms of the mechanism of action of acrylamide is discussed.
D020106:Acrylamide; D000178:Acrylamides / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D001369:Axons / Q000187:drug effects; D001921:Brain / Q000201:enzymology; D002415:Cats; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors; D006019:Glycolysis / Q000187:drug effects; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D009132:Muscles / Q000201:enzymology; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000378:metabolism; D010525:Peripheral Nerves / Q000201:enzymology; D010732:Phosphofructokinase-1 / Q000037:antagonists & inhibitors; D010751:Phosphopyruvate Hydratase / Q000037:antagonists & inhibitors; D014176:Protein Biosynthesis; D051381:Rats
D000178:Acrylamides; D020106:Acrylamide; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D010732:Phosphofructokinase-1; D010751:Phosphopyruvate Hydratase