White cells transfusion in recent onset type 1 diabetes.
Two HLA-identical brothers developed Type 1 diabetes simultaneously. In the light of present knowledge of the pathogenesis of Type 1 diabetes, immunosuppression was adopted in one brother by means of white cell transfusion from the father. The other brother acted as a control. This immunosuppressive approach has been shown to be effective in kidney transplantation and, as far as Type 1 diabetes is concerned, in the BB Wistar rat. An immunological and metabolic follow-up study of 1 yr only revealed slight differences between the 2 brothers (who are both on insulin) but the pattern of lymphocyte activation appeared to become normalized earlier in the transfused brother.
D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion; D002096:C-Peptide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D007328:Insulin / Q000627:therapeutic use; D017708:Leukocyte Transfusion; D008213:Lymphocyte Activation; D008297:Male; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D002096:C-Peptide; D007328:Insulin