Technetium Tc 99m plasmin in the diagnosis of inflammatory disease.
The localization characteristics of technetium Tc 99m plasmin were studied in experimental animals to investigate the use of 99mTc-plasmin for imaging inflammatory processes. At various times after abscess induction using turpentine in rats, the in vivo distribution properties of 99mTc-plasmin, gallium citrate Ga 67, 125I-fibrinogen, and 99mTc-human serum albumin (HSA) were studied by gamma-camera imaging. The in vivo binding of each radiopharmaceutical was also tested in rat and human plasma clots. Region-of-interest analyses of gamma-camera images showed relatively poor 99mTc-plasmin localization at sites of abscess formation. The ratio of abscess-to-control activity of this radiopharmaceutical did not exceed that of 67Ga, 125I-fibrinogen, or 99mTc-HSA. In vitro assays of each of the radiopharmaceuticals in plasma clots showed 99mTc-plasmin and 125I-fibrinogen to have the best localization characteristics.
D000038:Abscess / Q000000981:diagnostic imaging*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D005340:Fibrinogen; D005341:Fibrinolysin; D005710:Gallium Radioisotopes; D006801:Humans; D007457:Iodine Radioisotopes; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D051381:Rats; D012711:Serum Albumin, Radio-Iodinated; D013668:Technetium Tc 99m Aggregated Albumin
D005710:Gallium Radioisotopes; D007457:Iodine Radioisotopes; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D012711:Serum Albumin, Radio-Iodinated; D013668:Technetium Tc 99m Aggregated Albumin; C034360:technetium Tc 99m plasmin; D005340:Fibrinogen; D005341:Fibrinolysin