title: [Homozygotic C5 deficiency disclosed by purulent Neisseria meningitidis meningitis].
abstract: The complement system functions to protect the individual against infectious agents. Deficiencies of the late-acting complement proteins C5-C8 are associated with an increased susceptibility to Neisseria infection. This paper describes a deficiency in C5 in a Caucasoid family from the north of France that was revealed by the occurrence of a N. meningitidis meningitis in the homozygous C5-deficient propositus.
mesh_terms: D000328:Adult; D003182:Complement C5 / Q000172:deficiency* / Q000235:genetics; D006720:Homozygote; D006801:Humans; D007113:Immunity, Innate; D008297:Male; D008585:Meningitis, Meningococcal / Q000276:immunology*; D009345:Neisseria meningitidis; D012306:Risk
chemical_list: D003182:Complement C5
vernacular_title: Déficit homozygote en C5 révélé par une méningite purulente à Neisseria meningitidis.