[Building blocks for oligonucleotide syntheses with uniformly fragmentable beta-halogenated protective groups].
5'-Dimethoxytrityl-3'-phosphite amides of deoxynucleosides are synthesized. Phosphite/phosphate is protected by the 2,2,2-trichloro-1,1-dimethyl-ethyl (TCB) group, heterocyclic bases by the 2,2,2-trichloro-2,2-dimethyl-ethoxycarbonyl (TCBOC) group. Deoxyguanosine is also blocked by 6-O-trichloroethyl thus avoiding the difficulties observed with monoprotected guanine residues.
D003853:Deoxyribonucleosides; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*
D003853:Deoxyribonucleosides; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides
Bausteine für Oligonucleotid-Synthesen mit einheitlich fragmentierbaren beta-halogenierten Schutzgruppen.