title: Comparative in vitro activity of A-56268 (TE-031), a new macrolide antibiotic.
abstract: The in vitro activity of A-56268 (TE-031) was determined by either standard agar dilution or macrobroth tube dilution and compared with erythromycin and other antimicrobial agents against 329 clinical aerobic and anaerobic bacterial isolates. A-56268 showed good to excellent in vitro activity against methicillin-sensitive Staphylococcus aureus, Neisseria meningitidis, and most anaerobes tested with the exception of Bacteroides fragilis isolates. A-56268 had relatively poor activity against coagulase-negative staphylococci and methicillin-resistant Staphylococcus aureus. Except for Haemophilus spp., the activity of A-56268 was similar to or more potent than erythromycin against all other isolates tested. A-56268 did not have significant bactericidal activity against any of the isolates examined.
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D017291:Clarithromycin; D003470:Culture Media; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
chemical_list: D003470:Culture Media; D004917:Erythromycin; D017291:Clarithromycin