Dopamine D2 receptors increase in the dorsolateral striatum of weaver mutant mice.
Dopamine D2 receptors were studied in homozygous weaver mutant mice (wv/wv), heterozygous littermates (wv/+), and normal mice (+/+). Specific [3H]spiperone binding was significantly higher in the dorsolateral part of the striatum in the weaver mutant mice (wv/wv) than in normal mice (+/+). No significant differences among the 3 genotypes were found in other parts of the striatum or in the nucleus accumbens.
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000235:genetics / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000235:genetics / Q000378:metabolism*; D017448:Receptors, Dopamine D2; D013134:Spiperone / Q000378:metabolism
D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D013134:Spiperone