Histopathologic evaluation of the effects of etodolac in established adjuvant arthritis in rats: evidence for reversal of joint damage.
Histopathologic evaluation of hindpaws from control rats with established adjuvant arthritis showed severe alterations in soft tissue and bone, as well as progressive, moderate-to-severe articular changes. Following treatment with etodolac for 28 days, soft tissue and articular changes were rated mild, and bone changes were rated moderate, but with remodeling. These findings indicate that etodolac partially reversed the joint damage in these rats.
D000085:Acetates / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology; D003238:Connective Tissue / Q000473:pathology; D017308:Etodolac; D007596:Joints / Q000473:pathology; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew
D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D017308:Etodolac