Phosphoprotein B-50 in nerve growth cones from fetal rat brain.
The presynaptic, nervous tissue-specific phosphoprotein B-50 is present in infant and adult rat brain. In the present study we demonstrate that B-50 is a major phosphoprotein in nerve growth cones obtained from fetal rat brain. As this protein is an endogenous substrate for protein kinase C, an enzyme linked to cell growth and proliferation, a role for B-50 in nerve growth cone function is suggested.
D000818:Animals; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D001923:Brain Chemistry; D019922:GAP-43 Protein; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010750:Phosphoproteins / Q000032:analysis*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D019922:GAP-43 Protein; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; D011493:Protein Kinase C