[Effect of indomethacin on the sensitivity of the adreno- and cholinoreceptors in the cardiovascular system].
The effect of indometacin, an anti-inflammatory agent and prostaglandin biosynthesis inhibitor, on the sensitivity of cardiovascular adreno- and cholino-receptors was studied in anesthetized cats. 30-40 mg/kg of intraperitoneal indometacin reduced considerably alpha-adrenoceptor reactivity and increased beta-adrenoceptor sensitivity to exogenous mimetics. The drug effects on cholino-receptors are diverse and not always pronounced.
D000009:Abdominal Muscles / Q000187:drug effects; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects*; D002415:Cats; D006321:Heart / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D011898:Ranidae; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011976:Receptors, Muscarinic / Q000187:drug effects; D011978:Receptors, Nicotinic / Q000187:drug effects
D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D007213:Indomethacin
Vliianie indometatsina na chuvstvitel'nost' adreno- i kholinoretseptorov serdechno-sosudistoĭ sistemy.