IGF-2 stimulated growth mediated by the somatomedin type 2 receptor.
Human Insulinlike Growth Factor 2 (IGF-2) can promote cell proliferation via the type 2 receptor in K562 cells, a human erythroleukemia cell line with IGF-2/type 2 receptors and insulin receptors but lacking IGF-1/type 1 receptors. Cells are grown in semi-solid agar in the absence and presence of increasing amounts of insulin, IGF-1 and IGF-2. Two strains of K562 cells have been studied, with different concentrations of insulin and IGF-2 receptors. The effect of IGF-2 is proportional to the IGF-2 receptor concentration.
D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002999:Clone Cells; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology; D007335:Insulin-Like Growth Factor II / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D011972:Receptor, Insulin / Q000502:physiology*; D017451:Receptors, Somatomedin; D013002:Somatomedins / Q000494:pharmacology*
D007328:Insulin; D017451:Receptors, Somatomedin; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D011972:Receptor, Insulin