Organ distribution and metabolism of [13N]nicotinamide in mice.
The organ distribution and the metabolic fate of 13N[amide-13N]nicotinamide ([13N]NAM) were studied in order to evaluate its potential as a radiotracer. After administration, [13N]NAM is transported, mainly by simple diffusion, into the brain and heart, where part of the tracer is metabolized into hydrophilic compounds ([13N]NAD etc.) and trapped. A very high radioactivity is accumulated in the small intestine, probably due to bile duct excretion of the tracer and its metabolites. [13N]NAM was found to be a useful tracer for the study of the utilization of the vitamin, nicotinamide.
D000818:Animals; D002250:Carbon Radioisotopes; D007700:Kinetics; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009536:Niacinamide / Q000378:metabolism / Q000493:pharmacokinetics*; D009590:Nitrogen Radioisotopes; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D009590:Nitrogen Radioisotopes; D009536:Niacinamide