title: Compromised T-cell regulatory functions during anuran metamorphosis: the role of corticosteroids.
abstract: Glucocorticoid receptor concentrations, which are undetectable before metamorphosis, increase to a maximum during the metamorphic period and decline to toadlet levels thereafter. The generation of a high concentration of receptors, imparting enhanced glucocorticoid sensitivity particularly to the lymphoid tissues of metamorphic larvae suggests the possibility that increasing endogenous levels could be responsible for the compromised T-cell functions which have been described for these stages of development (Ruben et al, 1985a).
mesh_terms: D000305:Adrenal Cortex Hormones / Q000276:immunology*; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D003907:Dexamethasone / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology; D007108:Immune Tolerance; D007814:Larva / Q000276:immunology / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D008675:Metamorphosis, Biological; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology; D014982:Xenopus laevis / Q000276:immunology* / Q000378:metabolism
chemical_list: D000305:Adrenal Cortex Hormones; D003907:Dexamethasone