title: [Characteristics of the psychotropic effects of N-crown ether derivatives].
abstract: Acyl derivatives of crown esters containing amino acid derivatives as substitutes were studied. Derivatives of N-acylazacrown esters were found in experiments to display a broad spectrum of anticonvulsant activity, antiaggressive and tranquillizing effects and not to produce any sedative and myorelaxant actions. The profile of psychotropic activity of N-crown esters derivatives seems to be similar to that of atypic tranquillizers but the latters are less toxic.
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004988:Ethers, Cyclic / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D051379:Mice; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D000927:Anticonvulsants; D004988:Ethers, Cyclic; D011619:Psychotropic Drugs
vernacular_title: Osobennosti psikhotropnykh éffektov nekotorykh proizvodnykh N-kraunéfirov.