[Modification with bradykinin of membrane-bound lipid peroxidation and Ca2+-activity of the thymus and liver].
Effect of bradykinin on activity of Ca2+-ATPase and accumulation of malonic dialdehyde (MDA) was studied in proliferating and relatively non-proliferating (resting) cells of thymus and liver tissues. The peptide effect was studied in vivo and in vitro after intravenous administration into mice at a dose of 2 mg/kg or by means of addition of bradykinin (10(-6)M) to a suspension of calf thymocyte membranes. In vivo bradykinin caused the most distinct decrease in MDA accumulation and activation of Ca2+-ATPase in thymus as compared with liver tissue. In vitro incubation of thymocyte membranes with bradykinin led to prolongation of the latent period of MDA formation and to a distinct increase in the Ca2+-ATPase activity. Modification of these processes in membranes appear to be one of important functions of bradykinin in proliferation.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism; D051379:Mice; D013950:Thymus Gland / Q000201:enzymology / Q000378:metabolism*
D008054:Lipid Peroxides; D008563:Membrane Lipids; D008315:Malondialdehyde; D000252:Calcium-Transporting ATPases; D001920:Bradykinin
Modifikatsiia bradikininom memnranosviazannykh protsessov perekisnogo okisleniia lipidov i aktivnosti Ca2+-ATFazy timusa i pecheni.