Medroxyprogesterone acetate plasma pharmacokinetics after intravenous administration in rabbits.
Medroxyprogesterone acetate (MAP) plasma pharmacokinetics was followed up in a total of 30 New Zealand rabbits after i.v. administration (0.1, 0.5, and 1.0 mg/kg) of either an aqueous suspension or a homogeneous solution of the drug in dimethylsulphoxide (DMSO). A well-defined triphasic decay of MAP plasma levels was noticeable in the animals treated with DMSO solutions. A delayed concentration peak was often present when aqueous suspensions were used, so if is not feasible to fit the experiment with simple polyexponential equations. Model-independent pharmacokinetic analysis (statistical moment theory) revealed a significant dependence of plasma clearance and mean residence time on the dose administered in both conditions.
D000818:Animals; D002849:Chromatography, Gas; D004121:Dimethyl Sulfoxide; D005260:Female; D007700:Kinetics; D008297:Male; D008525:Medroxyprogesterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D017258:Medroxyprogesterone Acetate; D011817:Rabbits; D012996:Solutions; D013535:Suspensions
D012996:Solutions; D013535:Suspensions; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone; D004121:Dimethyl Sulfoxide