[Ontogenesis in man, of a population of neurons in the dorsal and lateral hypothalamus, secretors of a peptide that has not yet been characterized].
A human GRF 1-37 antiserum demonstrates a new neuronal system in lateral perifornical areas of the human hypothalamus. The molecule that is revealed in those neurons cannot be somatocrinin. Perikarya are abundant. They are observed beginning with the 9th week of development. alpha-MSH-like immunoreactivity, which is showed in the analogous cells of the rat, is not yet established in human. The early differentiation of those neurons and their abundance during the fetal life attest to the important neurophysiological function of the unidentified peptide they secrete.
D005333:Fetus / Q000032:analysis; D006801:Humans; D007031:Hypothalamus / Q000032:analysis / Q000166:cytology* / Q000378:metabolism; D007231:Infant, Newborn; D009474:Neurons / Q000032:analysis / Q000502:physiology*; D009479:Neuropeptides / Q000032:analysis* / Q000378:metabolism
D009479:Neuropeptides
Ontogenèse chez l'homme, d'une population de neurones de l'hypothalamus dorsal et latéral, sécréteurs d'un peptide non encore caractérisé.