Transgraft hemorrhage: a serious complication of low-dose thrombolytic therapy.
A 71-year-old woman came to the hospital with a 24-hour-old occlusion of the left limb of an aortoiliac knitted Dacron graft and was treated with an intra-arterial infusion of urokinase, 40,000 U/hr. Although the graft limb was successfully recanalized in 16 hours, the patient suffered a massive retroperitoneal hemorrhage through the wall of the graft. Clinicians must be aware of this potentially serious complication of thrombolytic therapy in patients with thrombosed, knitted Dacron grafts.
D000368:Aged; D001012:Aorta, Abdominal; D001807:Blood Vessel Prosthesis; D005260:Female; D006083:Graft Occlusion, Vascular / Q000188:drug therapy*; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007083:Iliac Artery; D011093:Polyethylene Terephthalates; D013927:Thrombosis / Q000188:drug therapy*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D011093:Polyethylene Terephthalates; D014568:Urokinase-Type Plasminogen Activator