Human recombinant lipocortin 1 inhibits prostacyclin production by human umbilical artery in vitro.
Submicromolar concentrations of human recombinant Lipocortin 1 inhibit the release of prostacyclin from human umbilical artery rings in a dose-dependent fashion. This is the first demonstration that the recombinant protein is effective in human cells.
D017302:Annexins; D001808:Blood Vessels / Q000187:drug effects*; D011464:Epoprostenol / Q000096:biosynthesis*; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D011994:Recombinant Proteins / Q000494:pharmacology; D014469:Umbilical Arteries / Q000187:drug effects / Q000378:metabolism
D017302:Annexins; D006023:Glycoproteins; D011994:Recombinant Proteins; D011464:Epoprostenol; D010740:Phospholipases; D010741:Phospholipases A