title: Is Down syndrome a modern disease?
mesh_terms: D002648:Child; D003409:Congenital Hypothyroidism / Q000175:diagnosis; D003937:Diagnosis, Differential; D004314:Down Syndrome / Q000175:diagnosis / Q000266:history*; D005060:Europe; D049668:History, 15th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D008512:Medicine in the Arts; D014481:United States