Natriuretic and hypotensive effects of alpha-human atrial natriuretic polypeptide in anaesthetized DOCA-salt hypertensive rats.
Both natriuretic and hypotensive effects of alpha-human atrial natriuretic polypeptide (alpha-hANP) were investigated in anaesthetized DOCA-salt hypertensive rats and control rats. An intravenous injection of two doses (0.3 and 3.0 micrograms/kg body weight) of alpha-hANP produced a rapid and marked increase in natriuresis and fall in blood pressure in DOCA-salt rats. Natriuretic and hypotensive effects of alpha-hANP in DOCA-salt rats were significantly greater than those in the control rats. It is suggested that DOCA-salt rats may have an enhanced natriuretic and hypotensive responsiveness to alpha-hANP.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000627:therapeutic use*; D001794:Blood Pressure; D003900:Desoxycorticosterone; D004231:Diuresis; D005260:Female; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D009318:Natriuresis / Q000187:drug effects*; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride
D003900:Desoxycorticosterone; D012965:Sodium Chloride; D009320:Atrial Natriuretic Factor; D011188:Potassium