Kinetic properties and physiological regulation of NAD glycohydrolase.
Kinetic studies on horse spleen NAD-glycohydrolase demonstrate that the hydrolysis of NAD+ is extensively inhibited by physiological concentrations of nicotinamide and NADP+. These compounds act as reversibly released product and competitive inhibitor respectively.
D000818:Animals; D006736:Horses; D007700:Kinetics; D008861:Microsomes / Q000201:enzymology; D009699:N-Glycosyl Hydrolases / Q000037:antagonists & inhibitors / Q000302:isolation & purification / Q000378:metabolism*; D009244:NAD+ Nucleosidase; D009249:NADP / Q000502:physiology; D009536:Niacinamide / Q000502:physiology*; D013154:Spleen / Q000166:cytology / Q000201:enzymology
D009536:Niacinamide; D009249:NADP; D009699:N-Glycosyl Hydrolases; D009244:NAD+ Nucleosidase