[Diagnostic value of determining neutral alpha-glucosidase and N-acetyl-beta-D-hexosaminidase activity in the urine in kidney pathology].
As shown in studies of 123 patients with various nephropathies, activities of alpha-glucosidase and N-acetyl-beta-D-hexosaminidase in urine of the patients correlated with severity and stages of these diseases; at the same time, simultaneous estimation of both enzymatic activities in urine was shown to be more informative in diagnostic of kidney impairments. Low values of correlation coefficient (r = 0.35 +/- 0.09) between daily excretion of protein and the activity of neutral alpha-glucosidase in urine showed that the enzyme activity did not depend on proteinuria and was independent test for kidney impairment. Estimation of alpha-glucosidase activity could be used for control of the therapy; the enzymatic activity in urine correlated distinctly with the clinico-laboratory patterns of the patients studied.
D058186:Acute Kidney Injury / Q000175:diagnosis; D000293:Adolescent; D000328:Adult; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis*; D007676:Kidney Failure, Chronic / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D000520:alpha-Glucosidases / Q000652:urine*; D001619:beta-N-Acetylhexosaminidases / Q000652:urine*
D000520:alpha-Glucosidases; D001619:beta-N-Acetylhexosaminidases
Diagnosticheskoe znachenie opredeleniia aktivnosti neĭtral'noĭ alpha-gliukozidazy i N-atsetil-beta-D-geksozaminidazy v moche pri patologii pochek.