Coexistence of atrial natriuretic factor (ANF) and oxytocin in neurons of the rat hypothalamus.
Sections of rat hypothalamus were examined immunocytochemically for coexistence of atrial natriuretic factor (cardiodilatin) and oxytocin. These biosynthetically unrelated neuropeptides were demonstrated using the peroxidase-antiperoxidase method followed by immunofluorescence. Neurons immunoreactive for atrial natriuretic factor were found in the supraoptic, periventricular and paraventricular nuclei. A sub-population of these neurons contained oxytocin-like immunoreactivity. They constitute only a small portion of the total number of oxytocinergic neurons.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D009320:Atrial Natriuretic Factor / Q000032:analysis*; D005260:Female; D007031:Hypothalamus / Q000166:cytology*; D007124:Immunoenzyme Techniques; D009474:Neurons / Q000166:cytology*; D010121:Oxytocin / Q000032:analysis*; D051381:Rats
D000936:Antigen-Antibody Complex; C472610:atrial natriuretic peptide, rat; D010121:Oxytocin; D009320:Atrial Natriuretic Factor