The use of monoclonal antibodies in the diagnosis of peripheral T-cell lymphomas.
Sixteen cases of peripheral T-cell lymphomas are described which are characterized immunologically by various methods including the use of monoclonal antibodies (Ab) to a variety of lymphocyte antigens. Seven cases were classified as helper/inducer and two as suppressor/cytotoxic phenotype. Four were considered T-cell, not otherwise specified, owing to lack of expression of subset phenotypic markers. Three cases were diagnosed prior to the advent of monoclonal Ab methods and were classified as being of T-cell origin by the E-rosette technique. In none of the cases was monotypic surface immunoglobulin or B-cell antigens expressed. The freeze-dried technique to prepare tissues for immunoperoxidase studies was found to be advantageous. The benefits and limitations of monoclonal Ab in the diagnosis of T-cell lymphomas are discussed.
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000276:immunology; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis*; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface