The immunosuppressive effect of streptozotocin-induced diabetes in rats.
Streptozotocin-diabetic isogenous Brown-Norway (BN) rats received heterotopic Wistar-Furth (WF X BN) F1 heart transplants. The functional graft survival time after different duration of diabetes and during insulin-treated diabetes was recorded. Some diabetic rats were challenged with sheep red cells, and their spleens were used in PHA stimulation and plaque-forming assays. Prolongation in heart transplant survival was found to be independent of the duration of diabetes. The prolongation disappeared promptly when insulin was administered to the diabetic rats. A depression of cellular immunoresponsiveness as measured by PHA stimulation assay was recorded during diabetes. Valid results were not obtained in the plaque-forming assay.
D000818:Animals; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000276:immunology*; D006084:Graft Rejection; D016027:Heart Transplantation; D007108:Immune Tolerance; D008213:Lymphocyte Activation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains / Q000145:classification; D012709:Serum Albumin / Q000032:analysis; D013311:Streptozocin; D014181:Transplantation Immunology
D012709:Serum Albumin; D013311:Streptozocin; D003404:Creatinine