Platelet deposition in rat heart allografts and the effect of a thromboxane receptor antagonist.
The effect of a thromboxane antagonist, L640,035 on platelet deposition in heart allografts was studied. Twenty Lewis rats received heterotopic allografts from Lewis x Brown-Norway F1 hybrid. All recipients received azathioprine (5 mg/kg/day). The rats were divided into three groups. Groups II and III were also treated daily with either the vehicle for L640,035 or L640,035 respectively. Syngeneic indium-111-labeled platelet deposition was determined in the allograft and the native heart at 6, 9, and 13 days after transplantation; group III was studied on the sixth and ninth day only. A rapidly increasing platelet deposition was seen in allografts from rats given azathioprine; whereas the thromboxane antagonist prevented the increase in platelet deposition on the ninth day.
D000818:Animals; D001379:Azathioprine / Q000494:pharmacology; D001792:Blood Platelets; D003988:Dibenzothiepins / Q000494:pharmacology*; D006085:Graft Survival / Q000187:drug effects; D016027:Heart Transplantation; D007204:Indium; D009206:Myocardium / Q000473:pathology; D010974:Platelet Aggregation / Q000187:drug effects*; D011868:Radioisotopes; D051381:Rats; D011917:Rats, Inbred Lew; D011982:Receptors, Prostaglandin / Q000187:drug effects; D017482:Receptors, Thromboxane; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors
D003988:Dibenzothiepins; D011868:Radioisotopes; D011982:Receptors, Prostaglandin; D017482:Receptors, Thromboxane; D007204:Indium; D013928:Thromboxane A2; C041107:L 640035; D001379:Azathioprine