Red blood cell aging--membrane skeleton alteration and IgG receptor expression.
Investigations were performed on aging of erythrocytes. It has been assumed that structural changes of the membrane result after exposer of the cells to certain environmental influences in vivo or in vitro. Cell aging can be connected with varying combinations of membrane structure disturbances. It is postulated that the messenger which signals membrane structure lesion is involved in a mechanism given by the expression of immunoglobulin G (IgG) receptor sites which bind autologous IgG1 and IgG3. This antibodies are cytophilic for macrophages. The performed studies demonstrated that an intact molecular arrangement of the membrane skeleton is not only a supposition for stabilization of the membrane asymmetry but also for IgG receptor masking to prevent an early elimination of the red blood cells from the organism.
D004905:Erythrocyte Aging; D004910:Erythrocyte Membrane / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D011961:Receptors, Fc / Q000378:metabolism*; D017452:Receptors, IgG; D013049:Spectrin / Q000032:analysis
D011961:Receptors, Fc; D017452:Receptors, IgG; D013049:Spectrin