Ketanserin and the cardiovascular system. 1. Modification of the effects of pressor amines in patients undergoing myocardial revascularisation.
The effect of 10 mg of ketanserin on the pressor responses to noradrenaline, phenylephrine and angiotensin II in 19 patients during cardiopulmonary bypass was observed. The results were compatible with the previously reported evidence that ketanserin, in addition to its antagonism of serotonin, causes alpha 1 adrenoceptor blockade.
D000804:Angiotensin II / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology*; D002315:Cardiopulmonary Bypass; D004341:Drug Evaluation; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007650:Ketanserin; D008875:Middle Aged; D009204:Myocardial Revascularization; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology*
D000959:Antihypertensive Agents; D010880:Piperidines; D000804:Angiotensin II; D010656:Phenylephrine; D007650:Ketanserin; D009638:Norepinephrine