Diabetic pregnancy managed with intraperitoneal insulin.
A woman with insulin-dependent diabetes (IDDM) and resistance to subcutaneously injected insulin conceived while being treated with intraperitoneal (i.p.) insulin administered through a recently developed subcutaneous peritoneal access device (SPAD). She continued on this regimen during the pregnancy and at 37 weeks was delivered of a normal baby by Caesarian section. During her pregnancy, she had 2 episodes of infection of the SPAD, which were rapidly controlled by local instillation of antibiotics. Her diabetes remained under excellent control (HbA1: 7.3-7.5%) throughout her pregnancy. This case demonstrates that in such patients i.p. administration of insulin through a SPAD is a feasible mode of management during pregnancy.
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007274:Injections, Intraperitoneal / Q000009:adverse effects / Q000295:instrumentation; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage*; D007333:Insulin Resistance; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000209:etiology; D011254:Pregnancy in Diabetics / Q000188:drug therapy*; D012646:Self Administration; D013203:Staphylococcal Infections / Q000209:etiology
D007328:Insulin