title: [Anaphylactoid reaction to trypsin following local administration of Dontisolon ointment].
abstract: We report on a female patient with known epicutaneous allergies, who developed type I allergy after oral local application of Dontisolon ointment. Epicutaneous tests with constituents of the ointment proved a positive reaction to trypsin-S-calcium glutaminate. We refer to similar cases of allergy to trypsin and chymotrypsin reported in the literature.
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced*; D004338:Drug Combinations / Q000008:administration & dosage / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology*; D010450:Endopeptidases / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009355:Neomycin / Q000008:administration & dosage / Q000009:adverse effects*; D009824:Ointments; D010328:Patch Tests; D010514:Periodontal Pocket / Q000188:drug therapy*; D010518:Periodontitis / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D014357:Trypsin / Q000008:administration & dosage / Q000009:adverse effects*; D014508:Urea / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D004338:Drug Combinations; D009824:Ointments; C001122:neomycin, prednisolone, surfen, trypsin-chymotrypsin drug combination; D014508:Urea; D011239:Prednisolone; D010450:Endopeptidases; D014357:Trypsin; D009355:Neomycin
vernacular_title: Anaphylaktoide Reaktion auf Trypsin nach lokaler Anwendung von Dontisolon-Salbe.