A case of immunoglobulin G conjugated with lactate dehydrogenase, producing both loss of enzyme activity and an abnormal isoenzyme pattern.
We present a patient with an inhibitor of lactate dehydrogenase (LD; EC 1.1.1.27) in serum, who had pericarditis and myocardial hypertrophy. The patient's LD activity in serum was low and the LD isoenzyme pattern was abnormal. The relative molecular mass of this abnormal LD-IgG complex was approximately 490 000. The patient's IgG reacted with all five LD isoenzymes.
D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis; D006332:Cardiomegaly / Q000201:enzymology; D011232:Chemical Precipitation; D002850:Chromatography, Gel; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology* / Q000302:isolation & purification; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors*; D008297:Male; D008970:Molecular Weight; D010493:Pericarditis / Q000201:enzymology
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase