[Proof of the effectiveness of a clotrimazole cream paste in acne vulgaris].
The efficacy of Clotrimazol cream paste containing a penetration enhancer in the treatment of acne vulgaris was objectified by investigating the sebum composition. Following treatment over three and six weeks, the ratio of triglyceride to free fatty acid significantly increased, which indicated an effective reduction of the lipase activity of Propionibacterium acnes within the sebaceous follicle.
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000378:metabolism; D003022:Clotrimazole / Q000627:therapeutic use*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D009824:Ointments; D012629:Sebum / Q000187:drug effects / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D007093:Imidazoles; D009824:Ointments; D014280:Triglycerides; D003022:Clotrimazole
Wirkungsnachweis einer Clotrimazol-Crèmepaste bei Acne vulgaris.