Importance of the interaction of midazolam and cimetidine.
Six healthy volunteers were given in an open study 15 mg of midazolam orally, and a couple of weeks later the same treatment preceded by 400 mg of cimetidine orally. We followed midazolam serum concentrations and the following pharmacodynamic parameters for five hours: subjective sedation, Maddox wing readings, critical flicker fusion frequency and peak velocity of saccadic eye movements. A statistically significant change was found in Cmax and total AUC between the two sessions. The pharmacodynamic responses differed also clearly from each other suggesting a significant change in midazolam effect even after a single oral dose of cimetidine.
D000328:Adult; D000704:Analysis of Variance; D001569:Benzodiazepines / Q000097:blood / Q000494:pharmacology*; D002927:Cimetidine / Q000097:blood / Q000494:pharmacology*; D004347:Drug Interactions; D005133:Eye Movements / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008874:Midazolam; D013997:Time Factors
D001569:Benzodiazepines; D002927:Cimetidine; D008874:Midazolam