[Differentiation of the effects of antispasmodic agents on the electromyogram of the sphincter of Oddi and the duodenum of the alert rabbit].
The electrical activity of the sphincter of Oddi and gastro-intestinal tract had been recorded on 21 negative atropineesterase conscious rabbits by means of chronically implanted electrodes located in the digestive wall. An analysis of the action of different spasmolytic and analgesic drugs was realized. Electromyograms of the sphincter of Oddi presented (a) isolated or in series spike potentials occurring independently of electrical activities of the duodenum (b) recurring spike potentials correlated with intestine spikes. The independent activity of the sphincter of Oddi was not controlled by the cholinergic system, contrary to the intestine-dependent activity (effect of the fempiverinium, atropine like drug). The pitofenone had inhibited the spike potentials of both the sphincter and intestine because its papaverinic effect. The noramidopyrine, analgesic drug without morphine-like effects, had induced activation and inhibition at low and high posology respectively.
D014670:Ampulla of Vater / Q000187:drug effects*; D000818:Animals; D001286:Atropine Derivatives / Q000494:pharmacology; D001577:Benzophenones / Q000494:pharmacology; D004177:Dipyrone / Q000031:analogs & derivatives / Q000494:pharmacology; D004338:Drug Combinations / Q000494:pharmacology; D004347:Drug Interactions; D004386:Duodenum / Q000187:drug effects*; D004576:Electromyography; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology; D047069:Pyrazolones; D011817:Rabbits; D009803:Sphincter of Oddi / Q000187:drug effects*
D001286:Atropine Derivatives; D001577:Benzophenones; D004338:Drug Combinations; D010276:Parasympatholytics; D010880:Piperidines; D047069:Pyrazolones; D004177:Dipyrone; C002416:fenpiverinium bromide, pitofenone hydrochloride, dipyrone drug combination; C015454:pitofenone; C008667:noramidopyrine
Différenciation des effets de substances antispasmodiques sur l'électromyogramme du sphincter d'Oddi et du duodénum chez le lapin vigile.