The calcium-sensitive dye arsenazo III inhibits calcium transport and ATP hydrolysis by the sarcoplasmic reticulum calcium pump.
The calcium-sensitive dye, arsenazo III, was found to interact with sarcoplasmic reticulum vesicles and to inhibit markedly the rate of calcium transport and ATP hydrolysis by these vesicles, thus perturbing the transport process it was meant to monitor. Caution should therefore be exercised when using this dye to monitor calcium movements.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D001150:Arsenazo III / Q000494:pharmacology*; D001391:Azo Compounds / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors; D006868:Hydrolysis; D066298:In Vitro Techniques; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism*
D001391:Azo Compounds; D001150:Arsenazo III; D000255:Adenosine Triphosphate; D000252:Calcium-Transporting ATPases; D002118:Calcium