[Bradykinin stimulates prolactin release in vitro].
Bradykinin (BK) is a nonpeptide, originally discovered in blood; recently BK has been localized in neurons and fibers of the hypothalamus. BK is a vasoactive substance which is involved in pain, inflammation and oedema. The present study demonstrates that BK is also a potent stimulator of prolactin (PRL) release from anterior pituitary cells in vitro. A significant enhancement of the release of PRL is observed at 1 nM BK. The stimulation of PRL release by BK is dose-dependent. This work shows that anterior pituitary cells in culture may serve as a useful model system in which to study the mechanism of action of BK.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002478:Cells, Cultured; D005260:Female; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D001920:Bradykinin
La bradykinine stimule la libération de prolactine in vitro.