[Indications and results of pituitary radiotherapy after microsurgery in acromegaly. 15 cases].
The present treatment of acromegaly consists of selective adenomectomy followed, when unsuccessful, by pituitary gland irradiation. Fifteen acromegalic patients were evaluated after adenomectomy, then radiotherapy. Growth hormone assays were performed after carbohydrate load and administration of thyroid stimulating hormone. Somatomedins were measured by radiocompetition using the vector protein. Cure was obtained with adenomectomy alone in 3 of the 15 patients (mean follow-up 39 months). The remaining 12 patients were all cured by subsequent irradiation at the cost of pituitary insufficiency in one-third of them. Post-surgical cure of acromegaly can only be asserted from range of strict criteria. The best indicators of persisting activity are high levels of growth hormone and/or somatomedins. A solitary somatotropic dysregulation does not necessarily herald a relapse.
D000172:Acromegaly / Q000097:blood / Q000628:therapy*; D000236:Adenoma / Q000532:radiotherapy*; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007016:Hypophysectomy; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D010910:Pituitary Irradiation; D010911:Pituitary Neoplasms / Q000532:radiotherapy*; D013002:Somatomedins / Q000097:blood
D013002:Somatomedins; D013006:Growth Hormone
Indications et résultats de la radiothérapie hypophysaire après microchirurgie dans l'acromégalie. Quinze cas.