Dopamine D2 receptors in the striatum and frontal cortex following chronic administration of haloperidol.
The effects of chronic treatment with a neuroleptic on D2 dopamine receptors in the striatum and frontal cortex were studied. Exposure to haloperidol for 21 days caused an upregulation in the striatum but not in the cortex of D2 receptors. These results indicate that dopamine-regulating mechanisms in the cortex may differ from those in the striatum and suggest that the anti-psychotic action of neuroleptics may be due in part to blockade of receptors in the cortex.
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects*; D005625:Frontal Lobe / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000032:analysis / Q000187:drug effects*; D017448:Receptors, Dopamine D2; D013134:Spiperone / Q000378:metabolism; D013997:Time Factors
D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D013134:Spiperone; D006220:Haloperidol