Absence of ototoxicity of teichomycin A2 in guinea pigs.
Teichomycin A2 is a new antibiotic that is similar to vancomycin. Because vancomycin is reported to be ototoxic, teichomycin A2 was tested for ototoxicity. No evidence of ototoxicity was found. Furthermore, ethacrynic acid, a diuretic that augments the ototoxicity of many drugs, did not enhance ototoxicity with teichomycin A2.
D000818:Animals; D003051:Cochlea / Q000187:drug effects; D004357:Drug Synergism; D004427:Ear Diseases / Q000139:chemically induced*; D004976:Ethacrynic Acid / Q000633:toxicity; D006020:Glycopeptides / Q000032:analysis / Q000494:pharmacology / Q000633:toxicity; D006168:Guinea Pigs; D010498:Perilymph / Q000032:analysis; D012018:Reflex / Q000187:drug effects; D017334:Teicoplanin
D006020:Glycopeptides; D017334:Teicoplanin; D004976:Ethacrynic Acid