title: [Concept of a hemogenetic paternity study using mixed lymphocyte culture (MLC). I. Theoretical considerations].
abstract: The chance of paternity exclusion shows 99.99% using 26 hemogenetic marker systems. Furthermore mixed lymphocyte culture-test (MLC) is able to exclude the falsely accused man in certain mother-child pairs. The lymphocyte culture of the child with his father's MLC haplotype can stimulate the maternal lymphocytes. The "primed" mother reacts in a second stimulation with the child's-father cells very strongly and in a short time of cultivation, but gives no reaction, when cultured with "non father" cells, lacking the paternal haplotype. All possible parents-sibling-combinations are noted and samples of positive and negative results in disputed paternity cases are demonstrated on basis of this new conception.
mesh_terms: D000328:Adult; D002648:Child; D005260:Female; D005838:Genotype; D006684:HLA-DR Antigens; D006238:Haploidy; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed / Q000379:methods*; D008297:Male; D010334:Paternity
chemical_list: D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II
vernacular_title: Konzept einer hämogenetischen Abstammungsuntersuchung mittels der gemischten Lymphozytenkultur (MLC). I. theoretische Uberlegungen.