title: Epidural mass associated with lack of efficacy of epidural morphine and undetectable CSF morphine concentrations.
abstract: A case is presented in which epidurally administered morphine failed to provide the expected extent and duration of pain relief. The patient had severe back pain in the upper lumbar and low thoracic regions and epigastric pain which was presumed to be caused by widespread metastatic deposits in the vertebral column from a prostatic carcinoma. The lack of clinical effect of epidural morphine was shown to be related to the unexpected presence of an epidural mass which was located below the dermatomal region for the patient's pain. Myelography and a CT scan indicated that the mass effectively compressed the subarachnoid space, thereby preventing the rostral spread of morphine in the cerebrospinal fluid (CSF) following lumbar epidural administration, resulting in inadequate pain relief.
mesh_terms: D000368:Aged; D000767:Anesthesia, Epidural; D001416:Back Pain / Q000188:drug therapy*; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004824:Epidural Space; D006801:Humans; D008297:Male; D009020:Morphine / Q000134:cerebrospinal fluid; D011471:Prostatic Neoplasms / Q000503:physiopathology*; D011859:Radiography; D013125:Spinal Neoplasms / Q000503:physiopathology / Q000556:secondary*; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging
chemical_list: D009020:Morphine