Soluble IL-2 receptor levels in serum from blood donors seropositive for HIV.
Serum levels of soluble IL-2R (sIL-2R) were measured in blood donors seropositive for HIV. Approximately one-half (53/101) of these seropositive donors exhibited increased serum sIL-2R levels compared with seronegative controls (n = 65). Further, a significant inverse correlation was observed between serum sIL-2R levels and CD4 cell levels in seropositive study participants. These findings suggest that increased serum sIL-2R levels in HIV infection may be linked to CD4 cell loss, and thus reflective of the stage of HIV-induced disease.
D001782:Blood Donors; D006679:HIV Seropositivity / Q000097:blood*; D006801:Humans; D007958:Leukocyte Count; D011971:Receptors, Immunologic / Q000097:blood*; D015375:Receptors, Interleukin-2; D012995:Solubility; D006377:T-Lymphocytes, Helper-Inducer
D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2