Genetic control of HLA-linked immune responsiveness to (H,G)-A-L.
Fifty-three donors belonging to seven families were tested for their immune response potential to (H,G)-A-L. Most of these donors had been previously tested for their ability to respond to (T,G)-A-L and were all HLA typed as well. The heredity of the ability to respond to (H,G)-A-L by the production of an antigen-specific helper T cell factor is compatible with an autosomal dominant trait linked to HLA. The genotype of an HLA-A/B recombinant individual suggested that a gene controlling the immune response to (H,G)-A-L is linked to HLA-A. Lod scores also suggested a linkage between immune response potential to (H,G)-A-L and HLA-A. The different patterns of responses to (T,G)-A-L and (H,G)-A-L observed in many individuals are compatible with the notion that separate loci are governing the immune responses to the two synthetic polypeptides.
D005260:Female; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D007519:Isoantigens / Q000235:genetics; D008297:Male; D010375:Pedigree; D010455:Peptides / Q000276:immunology*; D011108:Polymers; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D000949:Histocompatibility Antigens Class II; D007519:Isoantigens; D010455:Peptides; D011108:Polymers; C030815:poly-(His-Glu)-poly Ala-poly Lys