[The effect of clioquinol on nerve fiber regeneration following nerve crush injury].
The effect of clioquinol on regeneration of myelinated fibers of the sural nerve in rats was studied. Clioquinol suspended in polyethylen glycol (300 mg/kg body weight/day, test) and polyethylen glycol only (control) were administered for 14 and 21 days starting 7 days before the nerve crush. The number of regenerating myelinated fibers was examined histologically at 7 and 14 days after the nerve crush. In the control and test groups the regenerating fibers reached between 0-5 mm point from the crushed point at 7 days. The regenerating fibers reached between 15-20 mm point in the control group and between 5-10 mm point in the test group at 14 days. The rate of regeneration of myelinated fibers in test rats was significantly reduced compared with control.
D000818:Animals; D007464:Clioquinol / Q000494:pharmacology*; D006912:Hydroxyquinolines / Q000494:pharmacology*; D008297:Male; D009409:Nerve Crush; D009413:Nerve Fibers, Myelinated / Q000473:pathology / Q000502:physiology*; D009416:Nerve Regeneration / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013127:Spinal Nerves / Q000502:physiology*; D013497:Sural Nerve / Q000502:physiology*
D006912:Hydroxyquinolines; D007464:Clioquinol