title: [Experimental production of anencephalic monsters by chick embryo microsurgery. Initial observations].
abstract: 42 hour-old chick embryos are operated by microsurgical means. The encephalon, which is normally closed at this stage, is reopened and the incision extended to the level of 2nd or 3rd somites. The experimental embryos are anencephalic. Their comparison with a spontaneous anencephalus shows a large morphological similarity. These first experiments confirm the hypothesis by which anencephaly is a direct consequence of the failure of neural tube closure.
mesh_terms: D000757:Anencephaly / Q000209:etiology / Q000473:pathology; D000818:Animals; D002642:Chick Embryo; D004195:Disease Models, Animal
vernacular_title: Obtention expérimentale de monstres anencéphales par microchirurgie chez l'embryon de Poulet. Premières observations.