Intra arterial ketanserin in peripheral vascular disease.
An open study utilizing a serotonergic S2 antagonist, ketanserin, in a single 10mg intra arterial dose, was undertaken in eleven patients suffering various micro-vascular ischemic diseases. Ipsilateral limb blood flow improved 50%, skin temperatures rose 2.5 degrees C and venous oxygen tensions measured in the diseased foot showed modest elevation. The changes were significant and comparable to those achieved with chemical sympathectomy. These findings suggest ketanserin may have a place in the treatment of microvascular ischemic disease. However, systemic and contralateral flow induced changes suggested regional specificity was not obtained with arterial injection.
D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D007511:Ischemia / Q000188:drug therapy*; D007650:Ketanserin; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage / Q000627:therapeutic use*; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D013563:Sympathectomy, Chemical
D010880:Piperidines; D012702:Serotonin Antagonists; D007650:Ketanserin