Restenosis following percutaneous transluminal angioplasty: clinical, physiologic and pathological features.
Percutaneous transluminal coronary angioplasty (PTCA) has been used clinically for 8 years and is becoming widely accepted in the treatment of atherosclerotic coronary artery disease. Since the long-term effects of the procedure are unknown, the rate of restenosis following the procedure, approximately 30%, is of major concern. We briefly review the current status of PTCA and the effect of angioplasty on the vessel wall and discuss proposed mechanisms of recurrent stenosis.
D000800:Angioplasty, Balloon / Q000009:adverse effects; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D003326:Coronary Circulation; D003327:Coronary Disease / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D003331:Coronary Vessels / Q000293:injuries / Q000473:pathology; D003645:Death, Sudden / Q000209:etiology; D004727:Endothelium / Q000473:pathology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D010539:Permeability; D010973:Platelet Adhesiveness / Q000187:drug effects; D012008:Recurrence