Improvement in sensitivity of fast atom bombardment mass spectrometry of amino acids by di-isopropylphosphorylation.
Positive ion fast atom bombardment mass spectrometric sensitivities of seven amino acids and the corresponding di-isopropylphosphorylated derivatives were carefully compared. Results showed that an improvement in sensitivity by factors of 4-29, mostly above 10, were achieved after the derivatization. The chemical noise derived from glycerol matrix was also greatly reduced by this derivatization.
D000596:Amino Acids / Q000032:analysis*; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D009943:Organophosphorus Compounds / Q000032:analysis* / Q000138:chemical synthesis
D000596:Amino Acids; D007202:Indicators and Reagents; D009943:Organophosphorus Compounds