Overview of other topical retinoids.
It is clear that tretinoin has a major place in the treatment of acne via its effect on the abnormal pattern of keratinization, the initial pathophysiologic event in the disease. However, for purposes of introduction, it is useful to compare tretinoin with another topical retinoid, motretinide (Ro 11-1430), which is currently used in Europe. Herein is an overview of several studies that have examined the efficacy of these two agents.
D000152:Acne Vulgaris / Q000188:drug therapy*; D000287:Administration, Topical; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D014212:Tretinoin / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000627:therapeutic use
D014212:Tretinoin; C010832:motretinide