Abnormal n-nonacosane storage in humans: detection by gas chromatography/mass spectrometry of tissue extracts.
We report a case of n-nonacosane storage disease, which went undiagnosed until the death of a 55-year-old farmer. Clinical, histological, and biochemical features are discussed. n-Nonacosane storage was identified by gas chromatographic-mass spectrometric analysis of different tissue extracts, n-nonacosane concentration reaching 1.2 mg g-1 of lung tissue and 0.32 mg g-1 of liver tissue. It was possible to rule out a work-induced intoxication, and n-nonacosane storage appeared to be accounted for by a lifelong, heavy consumption of unpeeled apples and Brussels sprouts.
D000473:Alkanes / Q000032:analysis* / Q000506:poisoning; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007202:Indicators and Reagents; D008099:Liver / Q000032:analysis*; D008168:Lung / Q000032:analysis*; D008297:Male; D008875:Middle Aged
D000473:Alkanes; D007202:Indicators and Reagents; C047577:nonacosane