D-2 dopamine receptor synthesis and turnover in rat striatum.
Direct injection of phenoxybenzamine into rat striatum inhibited apomorphine-induced stereotyped behavior. This inhibition corresponded well with the inhibition of D-2 dopamine receptor labelling with [3H]spiroperidol. Both the behavioral response and the receptor level were completely restored within 5 days after the injection. The recoveries of both were blocked by cycloheximide. The rate of synthesis and half-life of the D-2 receptor associated with the stereotyped behavior were calculated to be 6.9 fmol/mg protein per h and 28 h, respectively.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors; D003342:Corpus Striatum / Q000378:metabolism*; D003513:Cycloheximide / Q000494:pharmacology; D008297:Male; D010643:Phenoxybenzamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D017448:Receptors, Dopamine D2; D013239:Stereotyped Behavior / Q000187:drug effects
D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D010643:Phenoxybenzamine; D003513:Cycloheximide; D001058:Apomorphine