title: Sources of rats free of latent Pneumocystis carinii.
abstract: Two sources of rats free of latent Pneumocystis carinii are described. First, rats from a virus-free colony failed to develop infection after 8 weeks of immune suppression unless they were housed with previously infected rats. Second, pregnant rats (non-virus free) received trimethoprim-sulfamethoxazole from day 10 of gestation until the pups were weaned. Pups raised in filter-topped cages and immunosuppressed for 8 weeks were free of P. carinii infection.
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D007165:Immunosuppression Therapy; D011020:Pneumonia, Pneumocystis / Q000517:prevention & control / Q000662:veterinary*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains / Q000469:parasitology*; D012376:Rodent Diseases / Q000517:prevention & control*; D013047:Specific Pathogen-Free Organisms; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
chemical_list: D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole