Scanning electron microscopy of antigen induced arthritic joints. I. Inflammatory cell interactions at synovial-meniscal surfaces during the Arthus response.
Scanning electron microscopy has been used to study experimental antigen induced arthritis, providing a unique perspective of the early inflammatory events. An initial aggregation of acute inflammatory cells was noted at the synovial-meniscal junction with maximal numbers observed between 12 and 24 h post challenge. Variations in cell surface ruffling, which may represent different phases of activation, were observed throughout the Arthus response. By 48 h post challenge the meniscal and synovial surfaces were covered by a mat of fibrin and degraded cell remnants.
D000818:Animals; D001183:Arthus Reaction / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D002462:Cell Membrane / Q000648:ultrastructure; D005260:Female; D005337:Fibrin / Q000032:analysis; D007114:Immunization; D007249:Inflammation; D008297:Male; D008592:Menisci, Tibial / Q000648:ultrastructure*; D008855:Microscopy, Electron, Scanning; D009504:Neutrophils / Q000648:ultrastructure; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000276:immunology / Q000633:toxicity; D013583:Synovial Membrane / Q000648:ultrastructure*; D013585:Synovitis / Q000209:etiology / Q000276:immunology / Q000473:pathology*
D012710:Serum Albumin, Bovine; D005337:Fibrin