IgD-binding factors from mouse T lymphocytes.
Incubation of normal mouse splenic lymphocytes with dimeric mouse IgD results in the formation of T-cell factors that selectively inhibit rosette formation of Fc delta receptor-positive lymphocytes with IgD-coated erythrocytes. The rosette-inhibiting factors bound to IgD-Sepharose and were recovered by elution at acid pH. The results indicate that the rosette-inhibiting factors are IgD-binding factors. Neither IgE-binding factors nor IgG-binding factors inhibited IgD rosettes. The IgD-binding factors induced by IgD consist of two species of molecular weight 78,000 and 37,000, respectively. The source of IgD-binding factors is Lyt-1+ T cells bearing Fc delta receptors. It appears that the binding of IgD to the receptors on the T cells induces the formation of IgD-binding factors.
D000818:Animals; D007072:Immunoglobulin D / Q000276:immunology / Q000378:metabolism*; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D008222:Lymphokines / Q000032:analysis* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc / Q000032:analysis; D017452:Receptors, IgG; D012397:Rosette Formation; D013154:Spleen / Q000032:analysis; D013601:T-Lymphocytes / Q000032:analysis*
D007072:Immunoglobulin D; D007074:Immunoglobulin G; D008222:Lymphokines; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc; D017452:Receptors, IgG; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors; D007073:Immunoglobulin E