Characterization of an unusual lipoprotein similar to human lipoprotein a isolated from the baboon, Papio sp.
An unusual lipoprotein was detected and purified from the blood of some members of a large colony of baboons, Papio sp. This lipoprotein was found to be similar to human lipoprotein a in all respects and is therefore termed lipoprotein a. Baboon lipoprotein a had a density of 1.052 g/ml and was located between low- and high-density lipoproteins in a density gradient ultracentrifugation. However, despite its greater density, baboon lipoprotein a was larger than low-density lipoprotein, based on gradient gel electrophoresis and gel filtration. The lipoprotein contained a very large apolipoprotein (apolipoprotein-lipoprotein a) which was found to consist of an apolipoprotein B linked to another protein called apolipoprotein a by a disulfide bridge(s). In all these characteristics, baboon lipoprotein a was similar to human lipoprotein a.
D000818:Animals; D001055:Apolipoproteins B / Q000032:analysis; D002499:Centrifugation, Density Gradient; D002850:Chromatography, Gel; D004220:Disulfides / Q000032:analysis; D004591:Electrophoresis, Polyacrylamide Gel; D017270:Lipoprotein(a); D008074:Lipoproteins / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D010215:Papio / Q000097:blood*
D001055:Apolipoproteins B; D004220:Disulfides; D017270:Lipoprotein(a); D008074:Lipoproteins; D008077:Lipoproteins, LDL