Effect of Withania somnifera on glycosaminoglycan synthesis in carrageenin-induced air pouch granuloma.
The effect of W. somnifera on glycosaminoglycan synthesis in the granulation tissue of carrageenin-induced air pouch granuloma was studied. W. somnifera was shown to exert significant inhibitory effect on incorporation of 35S into the granulation tissue. The uncoupling effect on oxidative phosphorylation (ADP/O ratio reduction) was also observed in the mitochondria of granulation tissue. Further, Mg2+ dependent ATPase activity was found to be influenced by W. somnifera. W. somnifera also reduced the succinate dehydrogenase enzyme activity in the mitochondria of granulation tissue.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001772:Blood Cell Count; D002351:Carrageenan; D006025:Glycosaminoglycans / Q000096:biosynthesis*; D006099:Granuloma / Q000139:chemically induced / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013431:Sulfates / Q000378:metabolism; D013462:Sulfur Radioisotopes; D014475:Uncoupling Agents
D006025:Glycosaminoglycans; D010936:Plant Extracts; D013431:Sulfates; D013462:Sulfur Radioisotopes; D014475:Uncoupling Agents; D002351:Carrageenan; D000251:Adenosine Triphosphatases; D010653:Phenylbutazone; D006854:Hydrocortisone