Comparative antitumor activity of ruthenium derivatives with 5'-deoxy-5-fluorouridine in chemically induced colorectal tumors in SD rats.
The activity of the newly synthesized ruthenium derivative imidazolium-bis(imidazole)tetrachlororuthenate (III) [ImH(RuIm2Cl4)] was compared with that of 5'-deoxy-5-fluorouridine (5'dFUR) in autochthonous acetoxy-methyl-methylnitrosamine (AMMN)-induced colorectal cancer in SD rats. Following coloscopic diagnosis of colorectal tumors treatment was administered twice weekly for a 10-week period. ImH(RuIm2Cl4) exhibited considerable antitumoral efficacy compared with 5'dFUR (20 T/C % and 60 T/C %, respectively) against the growth of AMMN-induced colorectal adenocarcinoma in SD rats. The mortality rates with ImH(RuIm2Cl4) were dose-related, but its efficacy did not vary in all doses administered.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives; D005467:Floxuridine / Q000627:therapeutic use*; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D009942:Organometallic Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D012004:Rectal Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D012428:Ruthenium / Q000627:therapeutic use*
D007093:Imidazoles; D009942:Organometallic Compounds; D005467:Floxuridine; C048589:imidazolium-bis(imidazole)tetrachlororuthenate(III); C014659:methyl(acetoxymethyl)nitrosamine; D012428:Ruthenium; D004128:Dimethylnitrosamine; C025034:doxifluridine