OKT4 epitope deficiency in a patient with acute myeloblastic leukemia.
The association of OKT4 epitope deficiency and acute myeloblastic leukemia (M1 by FAB) in a 12-year-old girl is reported. The patient's peripheral lymphocytes lacked the antigen identified by the OKT4 monoclonal antibody, but showed normal OKT4A and Leu-3a reactivity. Functional studies of the lymphocytes revealed normal responses to mitogens, but slightly reduced helper T cell function. The patient responded well to antileukemia chemotherapy and has been in remission for 30 months. The possible link between OKT4 epitope deficiency and the pathogenesis of AML is discussed.
D000911:Antibodies, Monoclonal; D002648:Child; D005260:Female; D006580:Genetic Carrier Screening; D006801:Humans; D007108:Immune Tolerance; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000276:immunology*; D007958:Leukocyte Count; D010641:Phenotype; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000911:Antibodies, Monoclonal