Calcium-related defects in cardiac and skeletal muscles of dystrophic mice.
Ca2+ ATPase and calcium binding proteins were studied in cardiac and skeletal muscles of normal and dystrophic mice. In normal and dystrophic mice, Ca2+ ATPase was quite reduced in cardiac muscle compared to skeletal muscle and was, unlike skeletal muscle, insensitive to orthovanadate. Ca2+ ATPase in skeletal muscle of dystrophic mice was reduced as compared to normal mice. In both cases (normal and dystrophic), calcium binding proteins were the same (identical molecular weight). The effect of 2 drugs (Polymixine B and Bepridil) which decrease protein bound calcium was studied: the muscle proteins of dystrophic mice did not present the same sensitivity to Bepridil as controls. These findings suggest the existence of a calcium-related defect in skeletal and cardiac muscle of dystrophic mice.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D015764:Bepridil; D002118:Calcium / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D008861:Microsomes / Q000378:metabolism; D009132:Muscles / Q000378:metabolism*; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D011112:Polymyxin B / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology; D013045:Species Specificity; D014638:Vanadates; D014639:Vanadium / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D002135:Calcium-Binding Proteins; D011759:Pyrrolidines; D014639:Vanadium; D014638:Vanadates; D015764:Bepridil; D000252:Calcium-Transporting ATPases; D011112:Polymyxin B; D002118:Calcium