title: Fixed drug eruption of the penis due to co-trimoxazole.
abstract: Fixed eruption of the penis, due to co-trimoxazole, is described in two boys. The eruption was accompanied by severe swelling of the penis, urine retention, and pain during micturition. The migration inhibiting factor assay for co-trimoxazole was negative, but the mast cell degranulation test was strongly positive, suggesting reaginic hypersensitivity reaction.
mesh_terms: D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D008297:Male; D010409:Penile Diseases / Q000139:chemically induced*; D013420:Sulfamethoxazole / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
chemical_list: D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole