Analgesic properties of enkephalinase inhibitors: animal and human studies.
D-phenylalanine, bacitracin and puromycin produce long-lasting, naloxone-reversible analgesia in mice. Analgesic potency parallels potency of these compounds as inhibitors of met-enkephalin degradation by mouse brain enzymes. D-phenylalanine potentiates acupuncture analgesia in mice and humans and has been used to ameliorate a variety of human chronic pain conditions.
D015670:Acupuncture Therapy; D000698:Analgesia; D000700:Analgesics; D000818:Animals; D001414:Bacitracin / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology; D004357:Drug Synergism; D004723:Endorphins / Q000378:metabolism; D004744:Enkephalin, Methionine / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D015260:Neprilysin; D010148:Intractable Pain / Q000628:therapy; D010649:Phenylalanine / Q000494:pharmacology*; D011480:Protease Inhibitors; D011691:Puromycin / Q000494:pharmacology*; D013237:Stereoisomerism; D001615:beta-Endorphin
D000700:Analgesics; D004723:Endorphins; D011480:Protease Inhibitors; D001414:Bacitracin; D009270:Naloxone; D010649:Phenylalanine; D011691:Puromycin; D004744:Enkephalin, Methionine; D001615:beta-Endorphin; D015260:Neprilysin