title: Expression of Ia antigens by murine kidney epithelium after exposure to streptozotocin.
abstract: In the normal murine kidney, Ia antigens are expressed by dendritic cells located within the interstitial connective tissue and scattered cells within the glomerulus. After receiving multiple low doses of streptozotocin, a nitrosourea derivative of glucose, kidney epithelium labeled intensely with anti-Ia antibodies. Ultrastructural immunohistochemistry indicated that the epithelial cells of the proximal convoluted tubules expressed Ia antigens on their basolateral surfaces while remaining Ia- on their luminal surfaces. This response to streptozotocin does not appear to be related to the diabetogenic potential of the drug, because BALB/cJ mice, which remain normoglycemic after treatment with streptozotocin, also exhibited strongly Ia+ tubular epithelium after treatment with streptozotocin.
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000276:immunology* / Q000473:pathology; D004848:Epithelium / Q000276:immunology / Q000648:ultrastructure; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006943:Hyperglycemia / Q000139:chemically induced / Q000276:immunology; D007668:Kidney / Q000276:immunology* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013311:Streptozocin / Q000633:toxicity*
chemical_list: D000949:Histocompatibility Antigens Class II; D013311:Streptozocin