title: [Structure and biological action of the atrial natriuretic factor (auriculin)].
abstract: The studies described in this report emphasize the potential importance of atrial natriuretic factor in affecting systemic and renal hemodynamics, sodium excretion and components of the renin-angiotensin-aldosterone system. It should be emphasized, however, that at present there is no direct and unequivocal evidence that ANF is secreted into the blood. Until this is done and until the factors that regulate its secretion have been established, its potential physiological role must remain speculative.
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects; D000450:Aldosterone / Q000096:biosynthesis; D000595:Amino Acid Sequence; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000032:analysis / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006439:Hemodynamics / Q000187:drug effects; D006978:Hypertension, Renovascular / Q000188:drug therapy / Q000503:physiopathology; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects; D009318:Natriuresis / Q000187:drug effects; D051381:Rats; D012079:Renal Circulation / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects; D013329:Structure-Activity Relationship; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
chemical_list: D000450:Aldosterone; D009320:Atrial Natriuretic Factor
vernacular_title: Struktura i biologicheskoe deĭstvie predserdnogo natriĭureticheskogo faktora (aurikulina).