Comparative efficacy of ciprofloxacin and ceftriaxone in experimental arthritis caused by Escherichia coli.
Ciprofloxacin was compared with ceftriaxone in a rabbit model of septic arthritis caused by Escherichia coli. Both agents significantly reduced mean E. coli counts in septic joint fluid (P less than 0.0005 versus untreated controls) and also within infected synovial tissue (P less than 0.01 versus controls). Ciprofloxacin regimens caused a higher frequency (P less than 0.05) of synovial tissue sterilization (53%) than did ceftriaxone (25%).
D000818:Animals; D001170:Arthritis, Infectious / Q000188:drug therapy* / Q000209:etiology; D002443:Ceftriaxone / Q000378:metabolism / Q000494:pharmacology*; D002939:Ciprofloxacin; D004927:Escherichia coli Infections / Q000188:drug therapy*; D005260:Female; D011804:Quinolines / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits; D013582:Synovial Fluid / Q000378:metabolism
D011804:Quinolines; D002939:Ciprofloxacin; D002443:Ceftriaxone