Stimulation of fetal growth associated with decreased maternal plasma oestrogen levels.
Reduced maternal and fetal plasma oestrogen levels were produced in rats by daily administration of an LH-RH agonist (obtained from IMPERIAL CHEMICAL INDUSTRIES; ICI product 118630) to the dams from day 12 of gestation. Fetuses from the treated mothers were significantly heavier and longer at delivery on day 21 of gestation than fetuses from control mothers. Placental weights were also greater in the treated group.
D000818:Animals; D002064:Buserelin / Q000031:analogs & derivatives / Q000494:pharmacology; D005314:Embryonic and Fetal Development / Q000187:drug effects; D004958:Estradiol / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005865:Gestational Age; D017273:Goserelin; D009929:Organ Size / Q000187:drug effects; D010920:Placenta / Q000033:anatomy & histology; D011247:Pregnancy; D051381:Rats
D017273:Goserelin; D004958:Estradiol; D002064:Buserelin