title: [Efficacy of high doses of molar lactate by the venous route in flecainide poisoning].
abstract: Three cases of intoxication by flecainide acetate were characterized by cardiovascular collapse with widening of the QRS complex at electrocardiography. In two of these patients, impairment of liver or renal function probably played a facilitating role. Infusion of molar sodium lactate in high doses resulted in rapid and durable clinical and electrocardiographic improvement. This effect of molar sodium lactate may tentatively be attributed to either displacement of flecainide from its tissue receptor sites, or to a decrease in the effect of flecainide by alteration of its action on the fast sodium channel, or to the beneficial effects of vascular filling.
mesh_terms: D000328:Adult; D000368:Aged; D004562:Electrocardiography; D005260:Female; D005424:Flecainide / Q000378:metabolism / Q000506:poisoning*; D006801:Humans; D007275:Injections, Intravenous; D007773:Lactates / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male
chemical_list: D007773:Lactates; D005424:Flecainide
vernacular_title: Efficacité de fortes doses de lactate molaire par voie veineuse lors des intoxications au flécaïnide.