The effect of a growth promoting drug, clenbuterol, on fibre frequency and area in hind limb muscles from young male rats.
The effect of dietary administration of clenbuterol on soleus and extensor digitorum longus muscles was studied after 4 and 21 days. Both muscles showed an increase in wet weight with no significant change in total fibre number. After 4 days fibre cross-sectional areas were increased in soleus, but not in extensor digitorum longus, and after 21 days there was a change in fibre frequencies in extensor digitorum longus but not soleus muscles.
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002976:Clenbuterol / Q000494:pharmacology*; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D004983:Ethanolamines / Q000494:pharmacology*; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D006614:Hindlimb; D008297:Male; D009132:Muscles / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D006005:Phosphorylases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D004983:Ethanolamines; D005993:Glycerolphosphate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase; D006005:Phosphorylases; D000252:Calcium-Transporting ATPases; D002976:Clenbuterol