[Modifications of the hepatotoxicity of cocaine on Swiss mice by various inhibitors].
Cocaine (50 mg/kg i. p.) in phenobarbital-treated mice induces hepatotoxicity. Treatment with SKF 525A, diazinon or diethylmaleate 30 minutes prior to cocaine demonstrates a metabolite responsibility for this trouble. However this metabolite reacts only weakly with glutathione and does not produce lipid peroxidation as measured by the thiobarbituric acid reaction.
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002784:Cholesterol / Q000097:blood; D003042:Cocaine / Q000633:toxicity*; D003976:Diazinon / Q000494:pharmacology*; D007306:Insecticides / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008298:Maleates / Q000494:pharmacology*; D051379:Mice; D011335:Proadifen / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D007306:Insecticides; D008298:Maleates; D014280:Triglycerides; D002784:Cholesterol; D011335:Proadifen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; C014476:diethyl maleate; D003042:Cocaine; D003976:Diazinon
Modifications de l'hépatotoxicité de la cocaïne chez la souris Swiss sous l'influence de divers inhibiteurs.