[Effect of serotoninergic and antiserotoninergic preparations on convulsions induced by the endogenous convulsants kynurenine and quinolinic acid].
Serotoninergic drugs DL-5-hydroxytryptophan, 5-methoxytryptamine (mexamine) and 5-hydroxytryptamine (serotonin) were found to reduce clonic convulsions induced by intracerebroventricular administration of DL-kynurenine sulfate in mice. Serotonin antagonist deseril weakened the antikynurenine effect of DL-5-hydroxytryptophan and mexamine. Quinolinic acid-induced convulsions could be attenuated only by DL-5-hydroxytryptophan. Deseril and metergoline and destruction of the cerebral serotoninergic neurons by 5,6-dihydroxytryptamine potentiated the convulsant effect of quinolinic acid but not kynurenine. The serotoninergic protective anticonvulsant mechanism is probably better developed against kynurenine rather than quinolinic acid.
D000818:Animals; D001921:Brain / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D007737:Kynurenine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011725:Pyridines / Q000494:pharmacology*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D012701:Serotonin / Q000627:therapeutic use*; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D013997:Time Factors
D011725:Pyridines; D011805:Quinolinic Acids; D011950:Receptors, Cholinergic; D012702:Serotonin Antagonists; D012701:Serotonin; D007737:Kynurenine; D017378:Quinolinic Acid
Vliianie serotoninergicheskikh i antiserotoninergicheskikh preparatov na sudorogi, vyzvannye éndogennymi konvul'santami kinureninom i khinolinovoĭ kislotoĭ.