title: Validation of criteria for major depression through controlled family study.
abstract: As compared with depressed relatives of normals, depressed relatives of affective patients are more likely to have severe impairment or incapacitation in their major life role when depressed, and more likely to suffer multiple episodes. These findings suggest that among major depressions, these clinical criteria may usefully identify cases with a familial, possibly genetic, vulnerability.
mesh_terms: D000367:Age Factors; D001714:Bipolar Disorder / Q000235:genetics*; D003866:Depressive Disorder / Q000235:genetics*; D006801:Humans; D011618:Psychotic Disorders / Q000235:genetics*; D012737:Sex Factors