[Changes in the level of anti-insulin antibodies and circulating immune complexes in diabetics treated with human insulin or monocomposed porcine insulin for a year. A multicenter study].
A double-blind multicentre study was performed during 1 year in 54 insulin-dependent diabetics, comparing human hemi-synthetic insulin and porcine MC-insulin. Anti-insulin antibodies and circulating immune-complexes significantly decreased in the human insulin group and were stable in the porcine insulin group. The level of antibodies was higher in patients with insulinic lipodystrophies. HbA1c, C-peptide, glucagon-stimulated levels and the number of hypoglycemias, were not significantly different in the two groups. These results confirm that human insulin is less antigenic than porcine insulin.
D000328:Adult; D000906:Antibodies / Q000032:analysis*; D000936:Antigen-Antibody Complex / Q000032:analysis*; D002986:Clinical Trials as Topic; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000276:immunology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007328:Insulin / Q000276:immunology* / Q000627:therapeutic use; D008297:Male; D013997:Time Factors
D000906:Antibodies; D000936:Antigen-Antibody Complex; D007328:Insulin
Variations du taux des anticorps anti-insuline et des immuns complexes circulants chez des diabétiques traités par insuline humaine ou porcine monocomposée pendant un an. Etude multicentrique.