[Anticholinergics as bronchodilators. An action profile].
In 3 test series comprising 107 patients the cholinergic proportion and the proportion of airway obstruction controllable by beta 2-sympathomimetics were determined. A reversible and an irreversible proportion of increased flow resistances in airways are detected. The reversible proportion has to be divided into a section controllable by beta 2-sympathomimetics. Both substance groups have an additive effect extending up to the irreversible proportion. In most cases, the proportion controllable by beta 2-sympathomimetics is larger than that controllable by anticholinergics. The cholinergic proportion of the airway obstruction can be blocked completely by 0.02 mg (0.04 mg) of the controlled dosage aerosol or by 0.125 mg iptratropium bromide (ITB), resp. The cardially recognizable anticholinergic effect is low in this connection. Complete cholinergic cardial block only occurs upon intravenous doses between 0.25 mg and 0.5 mg ITB.
D000284:Administration, Oral; D001993:Bronchodilator Agents; D004305:Dose-Response Relationship, Drug; D005280:Fenoterol / Q000494:pharmacology; D006801:Humans; D007275:Injections, Intravenous; D009241:Ipratropium / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology*
D001993:Bronchodilator Agents; D010276:Parasympatholytics; D005280:Fenoterol; D009241:Ipratropium
Anticholinergika als Bronchodilatatoren. Ein Wirkprofil.