Photodynamic therapy of ascites tumours within the peritoneal cavity.
A murine ascites tumour was treated with intraperitoneal haematoporphyrin derivative (HPD) and laser light (10mW, 514nm, Argon laser). HPD was given intraperitoneally 2 hours before 16 minute laser treatment. Uptake studies 2 hours after HPD injection showed 5-12 fold greater concentration of HPD in tumour cells than in 4 different normal tissues. A total of four HPD/laser treatments, given at 2 day intervals, resulted in 100% complete response; the cure rate was 85%. This study illustrates the effective use of intraperitoneal photodynamic therapy and opens the possibility of exploring different sensitizers, excitation wavelengths, and delivery systems in the treatment of human ascites tumours.
D000818:Animals; D001201:Ascites / Q000188:drug therapy; D005260:Female; D017324:Hematoporphyrin Derivative; D006414:Hematoporphyrin Photoradiation; D006415:Hematoporphyrins / Q000378:metabolism / Q000627:therapeutic use; D053685:Laser Therapy; D051379:Mice; D008809:Mice, Inbred C3H; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D013724:Teratoma / Q000188:drug therapy* / Q000378:metabolism; D014018:Tissue Distribution
D006415:Hematoporphyrins; D017324:Hematoporphyrin Derivative