Efficacy of ivermectin and levamisole against immature Dictyocaulus viviparus in cattle.
Eighteen calves aged approximately three months were each infected with Dictyocaulus viviparus larvae at a rate of 30/kg bodyweight. Seven days later they were randomly allocated to three groups of six animals. Calves of group 1 were controls. Calves of group 2 were given levamisole at a dose rate of 10 mg/kg and calves of group 3 were given ivermectin at a dose rate of 200 micrograms/kg. The anthelmintic activity of these two drugs was compared using clinical, functional, parasitological and pathological parameters. The results showed that the efficacy of ivermectin, given at a therapeutic dose, against immature D viviparus was higher than that of levamisole, given at double the recommended dose.
D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology; D004021:Dictyocaulus / Q000187:drug effects; D004022:Dictyocaulus Infections / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007559:Ivermectin; D007783:Lactones / Q000008:administration & dosage / Q000627:therapeutic use*; D007814:Larva / Q000187:drug effects; D007978:Levamisole / Q000008:administration & dosage / Q000627:therapeutic use*
D000969:Antinematodal Agents; D007783:Lactones; D007978:Levamisole; D007559:Ivermectin