title: [Immunogenicity and the protective effectiveness of the subunit trivalent influenza vaccine Grippovac].
abstract: In the process of the immunological approbation of several experimental batches of the triyalent subunit influenza vaccine Grippovac, the pronounced immunogenicity of the antigens of all strains contained in the vaccine was established; most of the vaccinees were found to retain sufficiently high antibody titers for a year, and the essential total increase of antibody titers was found to occur after a single booster immunization. The serological checking of the diagnosed cases of influenza among immunized and nonimmunized children, carried out in two boarding schools during the influenza epidemic in the winter of 1984-1985 provided the proofs of the high effectiveness of Grippovac in preventing viral influenza, types A and B: the decrease of influenza morbidity among the immunized children reached 79,5-67,2-66,5% and the total morbidity rate in influenza in these two boarding scholls dropped, on the average, 3,0-3,5 times.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D006801:Humans; D007114:Immunization; D007117:Immunization, Secondary; D007223:Infant; D009980:Influenza A virus / Q000276:immunology*; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control; D008875:Middle Aged; D012426:Russia; D013997:Time Factors; D014771:Virion / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines
vernacular_title: Immunogennost' i protektivnaia éffektivnost' sub"edinichnoĭ grippoznoĭ trekhvalentnoĭ vaktsiny "Grippovak".