B-cell lineage acute lymphoblastic leukemia with i(7q) and t(9;9)(p22;p24).
A 61-year-old Japanese male with acute lymphoblastic leukemia (ALL) is reported. Surface marker examinations revealed that the leukemic cells were of a B-cell lineage; the cells had common ALL antigens, Ia-like antigens, and B1 and B4 antigens. Chromosome analysis showed abnormalities of t(9;9)(p22;p24), as well as an isochromosome for the long arm of chromosome 7. The heritable fragile site at 9p was not detected in the peripheral blood cells of this patient at remission phase.
D000951:Antigens, Neoplasm / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology; D014408:Biomarkers, Tumor / Q000032:analysis; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015260:Neprilysin; D014178:Translocation, Genetic
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015260:Neprilysin