The inhibitory effect of granulocyte factor in mixed lymphocyte reaction.
The polymorphonuclear leukocytes (PMNLs) depress mixed leukocyte reaction (MLR) in vitro. The active factor involved in inhibition was found to be localized in the specific granules of PMNL. The adherent granulocytes secreted granulocyte factor (GF) which also diminished MLR. The functional activity of GF is reflected by inhibition of responding cell proliferation exclusively during induction of MLR; moreover, GF depresses generation of the specific suppressor cells associated with MLR. The effect of GF is modified using specific antisera.
D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008830:Microbodies / Q000276:immunology; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism; D013491:Suppressor Factors, Immunologic / Q000096:biosynthesis / Q000276:immunology
D013491:Suppressor Factors, Immunologic