title: [Absolute configuration and enantiomeric purity of celiprolol].
abstract: The absolute configuration of (+)-celiprolol ([alpha]D = +6.3 degrees in CHCl3) was established by a 9-step synthesis via the (+) (R)-acetonide of (R)-glyceraldehyde. This result was confirmed by the Cupra-A CD-spectra of the isopropyl and hydroxy analogs. The enantiomeric purity was determined by NMR analysis of the diastereomeric amide esters obtained by reaction of celiprolol with 2 mol of alpha-methoxy-alpha-trifluoromethyl-phenylacetic acid chloride (Mosher's reagent).
mesh_terms: D017272:Celiprolol; D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011412:Propanolamines / Q000032:analysis* / Q000302:isolation & purification; D013237:Stereoisomerism
chemical_list: D011412:Propanolamines; D017272:Celiprolol
vernacular_title: Absolute Konfiguration und enantiomere Reinheit von Celiprolol.