[Platelet release of dopamine in the common migraine attack].
Several arguments suggest that dopamine (DA) plays a role in the physiopathology of migraine. Conjugated and unconjugated plasma and platelet DA, as well as platelet phenolsulfotransferase M activity (responsible for DA sulfatation) were measured in 30 control subjects, 27 common migraine patients between attacks and 9 migraineurs during an attack. No modification of any of the parameters tested was detected in attack-free periods. During the attack no change of conjugated DA was observed; in contrast, a significant decrease of unconjugated platelet DA and a significant and correlated increase of plasma unconjugated DA were demonstrated. This corresponds to a release of unconjugated DA by the very dense bodies in platelets of migraine patients during the attack.
D000293:Adolescent; D000328:Adult; D000368:Aged; D015239:Arylsulfotransferase; D001792:Blood Platelets / Q000378:metabolism*; D004298:Dopamine / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000503:physiopathology*; D013466:Sulfurtransferases / Q000378:metabolism
D013466:Sulfurtransferases; D015239:Arylsulfotransferase; D004298:Dopamine
Libération plaquettaire de dopamine lors de la crise de migraine commune.