Immunosuppression following alloantigen exposure: a role for lymphocyte Fc gamma-receptor blocking antibodies.
In this study we have shown that IgG class, noncytotoxic, Fc gamma-receptor blocking antilymphocyte antibodies can de detected in a high proportion of patients who have previously been exposed to alloantigens, i.e. multiple transfused uraemic patients, haemophiliacs and male homosexuals. These antilymphocyte antibodies appear to cross-react with human spermatozoa. Monomeric IgG preparations from these patients were also found to significantly impair T-cell responsiveness in vitro. Depression of cell mediated immunity by these antibodies may contribute to prolonged graft survival in uraemic patients but may also predispose to infection.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000372:Agglutination Tests; D000906:Antibodies / Q000032:analysis*; D000961:Antilymphocyte Serum / Q000032:analysis; D001803:Blood Transfusion; D003429:Cross Reactions; D005260:Female; D006467:Hemophilia A / Q000276:immunology; D006716:Homosexuality; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular / Q000187:drug effects; D007074:Immunoglobulin G / Q000032:analysis; D007519:Isoantigens / Q000008:administration & dosage / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011961:Receptors, Fc / Q000276:immunology*; D017452:Receptors, IgG; D012397:Rosette Formation; D013094:Spermatozoa / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014511:Uremia / Q000276:immunology
D000906:Antibodies; D000961:Antilymphocyte Serum; D007074:Immunoglobulin G; D007519:Isoantigens; D011961:Receptors, Fc; D017452:Receptors, IgG