Effect of glucose administration on bilirubin excretion in the rabbit.
The effect of i.v. infusion of glucose on the hepatic handling of bilirubin was examined in rabbits. A significant increase in the excretion of conjugated bilirubin into the bile was observed, accompanied by a decrease in bilirubinemia. Hepatic bilirubin concentrations were lowered and the UDP-glucose concentrations and liver UDP-glucuronosyl and UDP-glucosyl transferase activities increased.
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism*; D001663:Bilirubin / Q000097:blood / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology*; D005964:Glucosyltransferases / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011817:Rabbits; D014532:Uridine Diphosphate Glucose / Q000378:metabolism
D005964:Glucosyltransferases; D014453:Glucuronosyltransferase; D005947:Glucose; D001663:Bilirubin; D014532:Uridine Diphosphate Glucose