title: A clinical and experimental study of colostomy blood flow and healing after closure.
abstract: Colostomy blood flow and healing have been studied in both man and rat. Laser Doppler velocimetry (LDV) was used to measure flow and showed a significant difference between colostomy blood flow measured at 1 week and at more than 8 weeks after fashioning (p less than 0.002). Hartmann colostomies were constructed in rats and closed at 3 or 6 weeks later. There was a correlation between distal colonic (stump) blood flow and anastomotic bursting pressures 3 days after closure in the 3-week group (r = 0.080; p less than 0.01). Colostomies closed at 6 weeks were significantly stronger than those closed at 3 weeks (p less than 0.02). Collagen concentration in proximal (stoma) colon was higher in the 6-week group compared with the 3-week group prior to anastomosis. There was also a fall in the proximal collagen after anastomosis in both 3- (p less than 0.01) and 6-week groups (p less than 0.01). Poor blood flow measured by LDV and colonic collagen concentration may predict poor healing after colostomy closure. LDV is a non-invasive technique with clinical application in this field.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D003106:Colon / Q000098:blood supply*; D003125:Colostomy; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow; D012212:Rheology; D014945:Wound Healing
chemical_list: D006909:Hydroxyproline