N-substituted 11-(4-piperidylene)-5,6-dihydro-11H-benzo-[5,6]cyclohepta [1,2-b]pyridines. Antihistamines with no sedating liability.
Conversion of the basic tertiary amino function of the potent antihistamine, azatadine (Optimine), to neutral carbamate function results in compounds which retain significant antihistamine activity with little or no CNS effects. In guinea pigs the N-ethoxycarbonyl derivative 4 had the same antihistamine potency as terfenadine, a clinically used non-sedating antihistamine. In mice, 4 was a potent antihistamine while lacking CNS effects. The 8-chloro-N-ethoxycarbonyl 5 (loratadine, Sch 29851) was the most potent antihistamine in the series, had no CNS side effects, and was selected for clinical evaluation.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003533:Cyproheptadine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology; D006993:Hypnotics and Sedatives; D017336:Loratadine; D008297:Male; D051379:Mice
D006633:Histamine Antagonists; D006993:Hypnotics and Sedatives; D003533:Cyproheptadine; D017336:Loratadine