title: Changes in the plasma levels of atrial natriuretic peptides during mineralocorticoid escape in man.
abstract: Plasma levels of atrial natriuretic peptide (ANP) were measured by radioimmunoassay in eight normal healthy volunteers before and during mineralocorticoid escape. Mean plasma ANP on a fixed sodium intake before fludrocortisone was 6.5 +/- SEM 1.1 pg/ml. Within 24 h of fludrocortisone administration there was a significant increase in plasma ANP which continued to increase daily reaching a plateau by day 4 (14.9 +/- 2.4 pg/ml) to day 7 (15.1 +/- 2.6 pg/ml). The rise in plasma ANP was closely related to the amount of sodium retained during the fludrocortisone treatment and the sodium 'escape' occurred by days 4 to 7. These results support the concept that ANP could play an important hormonal role in over-coming the sodium-retaining effects of mineralocorticoids in man.
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D005438:Fludrocortisone / Q000494:pharmacology; D006801:Humans; D008297:Male; D008901:Mineralocorticoids / Q000378:metabolism*; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism
chemical_list: D008901:Mineralocorticoids; D009320:Atrial Natriuretic Factor; D012964:Sodium; D012083:Renin; D005438:Fludrocortisone