Effect of ciprofloxacin on mitogen-stimulated lymphocyte proliferation.
Ciprofloxacin was tested for its inhibitory or stimulatory effects on concanavalin A- and phytohemagglutinin-stimulated proliferation (measured by [3H]thymidine uptake) of human peripheral blood mononuclear cells and murine splenocytes. Ciprofloxacin did not diminish or enhance mononuclear cell proliferation at concentrations of 5 to 125 micrograms/ml. Further, the proliferative response of splenocytes of mice previously treated with ciprofloxacin (40 mg/kg, twice daily for 5 days) was essentially similar to that of untreated controls.
D000818:Animals; D002939:Ciprofloxacin; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D010835:Phytohemagglutinins / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*
D010835:Phytohemagglutinins; D011804:Quinolines; D003208:Concanavalin A; D002939:Ciprofloxacin