title: [Refractory cancer pain. Subarachnoid or epidural administration of morphine].
abstract: Spinal analgesia, a new method for relieving refractory cancer pain, was tested in 19 patients. A catheter was installed in the subarachnoid (17 cases) or peridural (2 cases) space and connected to a subcutaneous site of injection. The success rate at 10 days was 68%. In 11 patients pain was relieved throughout the course of the malignant disease, with doses that did not exceed 6 mg in 7 patients and 10 mg in the remaining 4 patients. The most severe complications were leakage of the cerebrospinal fluid in 1 case, meningitis after 18 months of injection in 1 case and displacement of the catheter in 3 cases.
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007268:Injections, Epidural; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage*; D009369:Neoplasms / Q000503:physiopathology*; D010146:Pain / Q000188:drug therapy*
chemical_list: D009020:Morphine
vernacular_title: Douleurs cancéreuses rebelles. Administration de morphine par voie sous-arachnoïdienne ou péridurale.