Multiply resistant Salmonella typhimurium septicaemia in an immunocompromised patient successfully treated with ciprofloxacin.
A patient with acute lymphoblastic leukaemia developed a septicaemia due to a multiply resistant strain of Salmonella typhimurium probably contracted in Pakistan. This was associated with splenic abscesses and proved resistant to treatment with a succession of beta-lactam antibiotics--ceftazidime, imipenem, and mecillinam despite in-vitro sensitivity. The infection resolved completely with ciprofloxacin therapy--a new 4-quinolone antibiotic which may have an important role in the treatment of systemic salmonella infections.
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002939:Ciprofloxacin; D004352:Drug Resistance, Microbial; D006801:Humans; D007165:Immunosuppression Therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008297:Male; D009503:Neutropenia / Q000150:complications; D011804:Quinolines / Q000627:therapeutic use*; D012480:Salmonella Infections / Q000209:etiology*; D012486:Salmonella typhimurium / Q000187:drug effects; D018805:Sepsis / Q000209:etiology / Q000382:microbiology*
D011804:Quinolines; D002939:Ciprofloxacin