Structural and functional aspects of metal-thiolate centres in metallothionein.
The structural parameters of the metal thiolate binding centres in metallothionein are summarized. Regardless of biological origin there appears to be a general concept. Four thiolate sulphurs are tetrahedrally arranged around a d10 metal. One functional aspect dealing with the direct metal transfer from these clusters into the vacant metal binding sites of many a copper and/or zinc protein is shown.
D000818:Animals; D001665:Binding Sites; D003035:Cobalt / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D003545:Cysteine / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008668:Metallothionein / Q000378:metabolism*; D008670:Metals / Q000378:metabolism*; D009492:Neurospora crassa / Q000032:analysis; D012441:Saccharomyces cerevisiae / Q000032:analysis; D013053:Spectrophotometry; D013552:Swine; D015032:Zinc / Q000378:metabolism
D008670:Metals; D003035:Cobalt; D003300:Copper; D008668:Metallothionein; D015032:Zinc; D003545:Cysteine