Phenylpropanolamine: an over-the-counter drug causing central nervous system vasculitis and intracerebral hemorrhage. Case report and review.
Phenylpropanolamine (PPA) is the major ingredient in more than 70 over-the-counter preparations including diet pills, nasal decongestants, and the legal "look-alike" stimulants. Structurally and functionally similar to amphetamine and ephedrine, PPA has recently been associated with several neurological manifestations including psychosis, stroke, severe headache, seizures, and intracerebral hematoma. We report a case of intracerebral hematoma and subarachnoid hemorrhage in a young woman with angiographic and biopsy-proven vasculitis of the central nervous system (CNS) induced by PPA in her diet pills. From review of the literature, we distinguish drug-induced vasculitis as a separate entity from primary CNS vasculitis, both clinically and pathologically. This report should alert physicians, in general, to this potentially fatal side effect of PPA, a commonly used over-the-counter drug. Also, neurosurgeons in particular should consider the possibility of drug-induced vasculitis when faced with cases of intracerebral or subarachnoid hemorrhage without apparent cause.
D000328:Adult; D001921:Brain / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000139:chemically induced; D002561:Cerebrovascular Disorders / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006406:Hematoma / Q000139:chemically induced; D006801:Humans; D007105:Immune Complex Diseases / Q000139:chemically induced; D004366:Nonprescription Drugs / Q000009:adverse effects; D010665:Phenylpropanolamine / Q000009:adverse effects*; D013345:Subarachnoid Hemorrhage / Q000139:chemically induced; D014657:Vasculitis / Q000139:chemically induced* / Q000473:pathology
D004366:Nonprescription Drugs; D010665:Phenylpropanolamine