[Liver regeneration and the immune system. III. Suppressor activity of splenic adherent cells activated in vivo by liver regeneration].
It has been shown in the previous reports the immune system of mice is activated during liver regeneration following partial hepatectomy and lymph node cells activated in vivo suppress the syngeneic mixed hepatectomized liver cell-lymphocyte reaction (sMLHLR). In this report, it is demonstrated that the suppressor activity of lymphocytes in vivo by liver regeneration exists in lymph node T cells and splenic adherent cells, but not in lymph node B cells. This suppressive activity of splenic adherent cells is blocked with indomethacin or aspirin. Each of these compounds in nontoxic doses inhibited macrophage-mediated suppression suggesting that the release of prostaglandins by macrophages played an essential role in inhibiting the sMLHLR.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D005260:Female; D006498:Hepatectomy; D007108:Immune Tolerance / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D008115:Liver Regeneration; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D013154:Spleen / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D001241:Aspirin; D007213:Indomethacin