title: Acne vulgaris in childhood. Pathogenesis and management.
abstract: Acne vulgaris is a common skin disorder. Although it is most prevalent in the second decade of life, its beginnings are heralded by increased activity of the sebaceous glands and faulty follicular keratinization, which are already evident in mid to late childhood. The subsequent and increasing proliferation of the follicular anaerobic diphtheroid microflora contribute further as an important pathogenic factor in the generation of inflammatory lesions. Treatments of acne, therefore, are aimed at reducing the follicular anaerobic bacteria, counteracting the follicular hyperkeratosis, and inhibiting the activity of sebaceous glands.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy / Q000209:etiology*; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D001424:Bacterial Infections / Q000209:etiology; D001585:Benzoyl Peroxide / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007536:Isomerism; D015474:Isotretinoin; D007642:Keratosis / Q000209:etiology; D008297:Male; D011425:Propionibacterium acnes; D012627:Sebaceous Glands / Q000378:metabolism / Q000382:microbiology; D012629:Sebum / Q000378:metabolism; D014212:Tretinoin / Q000627:therapeutic use; D014222:Triamcinolone Acetonide / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D014212:Tretinoin; D015474:Isotretinoin; D014222:Triamcinolone Acetonide; D001585:Benzoyl Peroxide