Dietary fat alters progression of some age-related changes of the immune system.
SJL mice develop resistance against tolerance between the 9th and 25th wk of life. This resistance is linked with a loss of suppressor capacity in the thymus. We have shown here that contact photosensitivity (CPS) decreases as a function of age and that this is due to an age-dependent increase in suppressor capacity. Diet fats have a differential effect on age-dependent changes in suppressor activity; a low P/S diet prevents or delays loss of suppressor activity for antibody formation and a high P/S diet prevents or delays the development of suppressor activity in CPS reactions.
D000375:Aging; D000818:Animals; D000917:Antibody Formation; D003520:Cyclophosphamide / Q000494:pharmacology; D004041:Dietary Fats / Q000502:physiology*; D005227:Fatty Acids / Q000502:physiology; D005231:Fatty Acids, Unsaturated / Q000276:immunology; D006967:Hypersensitivity / Q000276:immunology*; D007109:Immunity; D008027:Light; D051379:Mice; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
D004041:Dietary Fats; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D003520:Cyclophosphamide