[Delayed hypersensitivity reaction to transplantation antigens in mice with induced tolerance for allo- and xenografts].
The delayed-type hypersensitivity reaction (DTH) in mice tolerant to allo- and xenoantigens has been investigated. To induce tolerance adult mice were thymectomized and given 1 X 10(8) allogeneic or xenogeneic spleen cells and cyclophosphamide (200 mg/kg). Such mice failed to develop DTH to donor antigens, while DTH reaction to foreign allo- and xenoantigens was retained. Spleen cells of mice tolerant to alloantigens significantly suppressed the afferent and efferent DTH phases. The suppression was specific and T-cell-mediated. Spleen cells of mice tolerant to xenoantigens could suppress only the afferent DTH phase. The treatment of cells with anti-T-globulin and complement did not abrogate the suppression. The role of DTH suppressors in the induction and maintenance of transplantation tolerance is discussed.
D000818:Animals; D006168:Guinea Pigs; D006649:Histocompatibility Antigens / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007108:Immune Tolerance; D007114:Immunization; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013934:Thymectomy; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
D006649:Histocompatibility Antigens
Issledovanie reaktsii giperchuvstvitel'nosti zamedlennogo tipa k transplantatsionnym antigenam u mysheĭ s indutsirovannoĭ tolerantnost'iu k allo- i ksenotransplantatam.