The antimetastatic and tumor growth retarding effects of sulfur containing analogs of nicotinamide.
Several sulfur containing 5- and 6-membered heterocyclic carboxylic acids (or esters) were shown to decrease the number of pulmonary metastases in C57BL/6 mice implanted with Lewis lung carcinoma. The numbers of such metastatic nodules were reduced more than 5-fold. In addition, these compounds, which could be viewed as analogs of nicotinamide, were shown to inhibit the growth rate of the primary implanted tumor by about 50%.
D000818:Animals; D005260:Female; D008175:Lung Neoplasms / Q000473:pathology / Q000517:prevention & control* / Q000556:secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013439:Sulfhydryl Reagents / Q000627:therapeutic use*
D013438:Sulfhydryl Compounds; D013439:Sulfhydryl Reagents; D009536:Niacinamide