Immune dysregulation in human tuberculosis.
Hyporesponsiveness to mycobacterial antigens occurs in some patients with tuberculosis. Active immunosuppression by monocytes, T-lymphocytes, and serum is evident and may be a critical factor in anergy. The molecular basis for depressed responsiveness to tuberculin antigens is uncertain, but may involve aberrant surface expression of the HLA-DR gene product on adherent mononuclear cells and abnormalities in immune induction and the cytokine cascade.
D001770:Blood Bactericidal Activity; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007375:Interleukin-1 / Q000276:immunology; D007376:Interleukin-2 / Q000378:metabolism; D008213:Lymphocyte Activation; D009000:Monocytes / Q000276:immunology; D010586:Phagocytes / Q000276:immunology; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014373:Tuberculin / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology*
D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D007375:Interleukin-1; D007376:Interleukin-2; D014373:Tuberculin