Familial t(4;21)(q2.4;q2.2) leading to an unbalanced offspring with the Down syndrome.
D002891:Chromosomes, Human, Pair 21; D002894:Chromosomes, Human, Pair 4; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010375:Pedigree; D014178:Translocation, Genetic