Dissociation of thrombin generation and platelet secretion in diabetes mellitus.
To determine the relationship between thrombin generation and platelet secretion in vivo in diabetes mellitus, we measured simultaneous plasma beta-thromboglobulin (BTG) and fibrinopeptide A (FPA) in 40 insulin-dependent patients without renal disease, and 20 control subjects of similar age. Log mean plasma BTG and FPA were higher in diabetic patients (32.1 vs 23.7 ng/ml, and 2.83 vs 1.49 ng/ml, p less than 0.001 and less than 0.005, respectively). Neither was correlated with plasma glucose or hemoglobin AI. Plasma BTG and FPA were moderately intercorrelated in control subjects (r = +0.36, p = 0.03), but not in diabetic patients (r = +0.09, p = NS). Thus, in diabetes mellitus, thrombin generation as a contributing mechanism to platelet secretion is probably overshadowed by thrombin-independent mechanisms.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D005344:Fibrinopeptide A / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013917:Thrombin / Q000096:biosynthesis*; D001620:beta-Thromboglobulin / Q000032:analysis
D001620:beta-Thromboglobulin; D005344:Fibrinopeptide A; D013917:Thrombin