[T-lymphocyte subpopulations in the blood of patients with chronic B-cell lympholeukemia studied using monoclonal antibodies].
The contents of T-lymphocytes and their basic subpopulations (T-helpers and T-suppressors) in peripheral blood of 40 patients with B-cellular chronic lymphatic leukemia was studied (CLL) using monoclonal antibodies. It is shown that an imbalance of T-helpers and T-suppressors is observed in many patients (a ratio of helpers/suppressors less than 1.29 in 24 patients) at the expense of a decrease in the relative content of T-helpers in patients at stage I-III of CLL and an increase in the contents of T-suppressors in patients at stage IV. A correlation is revealed between the ratio of T-helpers and T-suppressors, on the one hand, and the stage of the disease, on the other hand.
D000911:Antibodies, Monoclonal / Q000032:analysis*; D001402:B-Lymphocytes; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000473:pathology; D007958:Leukocyte Count; D008297:Male; D009367:Neoplasm Staging; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal
Issledovanie subpopuliatsiĭ T-limfotsitov v krovi bol'nykh B-kletochnym khronicheskim limfoleĭkozom s pomoshch'iu monoklonal'nykh antitel.