title: Oral hyposensitization to poison ivy and poison oak.
abstract: We evaluated the safety and efficacy of a 1:1 mixture of pentadecylcatechol (PDC) and heptadecylcatechol (HDC) diacetate in reducing hypersensitivity to poison ivy and poison oak. The study was double-blind, parallel, randomized, and placebo controlled. The 44 subjects receiving the active drug ingested a cumulative dose of 306.5 mg over a five-week period. Subsequently, 14 patients were continued on a maintenance phase, ingesting an additional 960 mg of drug. The PDC-HDC diacetate was well tolerated, with no significant side effects. Evaluation of efficacy compared poststudy and prestudy reactions to patch tests using urushiol in doses of 0.025, 0.05, 0.125, 0.25, and 0.5 micrograms applied to the forearm. The results indicated that the induction phase as well as the maintenance phase did not induce a statistically significant hyposensitivity to urushiol, and we were thus unable to decrease sensitivity to poison ivy and poison oak in humans using orally ingested PDC-HDC diacetate.
mesh_terms: D000284:Administration, Oral; D002396:Catechols / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D011040:Dermatitis, Toxicodendron / Q000276:immunology / Q000628:therapy*; D003888:Desensitization, Immunologic / Q000379:methods*; D004311:Double-Blind Method; D004338:Drug Combinations; D006801:Humans; D011897:Random Allocation
chemical_list: D002396:Catechols; D004338:Drug Combinations; C034998:3-heptadecylcatechol; C005297:3-pentadecacatechol