title: Effect of serotonin and beta-endorphin on the release of luteinizing hormone in the hen (Gallus domesticus).
abstract: Serotonin (5-hydroxytryptamine) and beta-endorphin administered into the third ventricle of the hen blocked normal and progesterone-induced ovulation, and suppressed the release of LH in normal and progesterone-injected hens. p-Chlorophenylalanine, an inhibitor of serotonin synthesis, caused the release of LH and diminished the effect of beta-endorphin. Naloxone, an antagonist of opiate peptides, diminished the effect of beta-endorphin but not the effect of serotonin. The results suggest that both serotonin and beta-endorphin are involved in the control of LH release in the hen as an inhibitory agent, and serotonin is predominant while beta-endorphin is subsidiary to the inhibition of the LH release.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects; D002645:Chickens / Q000097:blood*; D004723:Endorphins / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D007276:Injections, Intraventricular; D007986:Luteinizing Hormone / Q000097:blood*; D009270:Naloxone / Q000494:pharmacology; D010060:Ovulation / Q000187:drug effects; D011374:Progesterone / Q000494:pharmacology; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*; D001615:beta-Endorphin
chemical_list: D004723:Endorphins; D012701:Serotonin; D009270:Naloxone; D011374:Progesterone; D001615:beta-Endorphin; D007986:Luteinizing Hormone; D010134:Fenclonine