Human leukemic cells: receptor binding and biological effects of insulin and insulin-like growth factors.
Receptor binding and biological effects of insulin and insulin-like growth factors I and II (IGF I/II) were assessed in three human malignant cell lines: a Burkitt-type ALL-cell line, a ANLL-cell line and a Hodgkin's disease-cell line. Insulin receptor binding could be demonstrated in Burkitt-type ALL cells and ANLL cells, whereas no insulin receptor binding was detectable in Hodgkin cells. IGF I and IGF II binding could be demonstrated in all leukemic cells. Insulin stimulated glycogen synthesis in the insulin receptor bearing cell lines. DNA synthesis was stimulated by insulin, IGF I and II. IGF I was more active in stimulating DNA synthesis than IGF II.
D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D006003:Glycogen / Q000096:biosynthesis; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D007938:Leukemia / Q000378:metabolism*; D011972:Receptor, Insulin / Q000032:analysis*; D017451:Receptors, Somatomedin; D013002:Somatomedins / Q000494:pharmacology*
D007328:Insulin; D017451:Receptors, Somatomedin; D013002:Somatomedins; D006003:Glycogen; D004247:DNA; D011972:Receptor, Insulin