title: [Fosfomycin-cefotaxime combination in severe staphylococcal infections in newborn infants].
abstract: Clinical and bacteriological effectiveness of the fosfomycin-cefotaxime combination is reported in four cases of serious staphylococcal infections in neonates (1 meningitis, 2 osteomyelitis, 1 superinfection of congenital varicella). Owing to the strong synergistic effect of this combination on methicillin-resistant staphylococcal strains, the authors suggest that the fosfomycin-cefotaxime combination should be considered for anti-staphylococcal therapy in neonates with deep tissue and/or methicillin-resistant infections.
mesh_terms: D002439:Cefotaxime / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005578:Fosfomycin / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus; D013212:Staphylococcus epidermidis
chemical_list: D005578:Fosfomycin; D002439:Cefotaxime
vernacular_title: L'association fosfomycine-céfotaxime dans les infections sévères staphylococciques du nouveau-né.