[Immunohistochemical and electron microscopic identification of serotonin, melatonin and beta-endorphin in the granules of natural killers].
The ability of serotonin, melatonin and beta-endorphin synthesis by secreting granules of natural killer cells (NK cells) was established by immunohistochemical method. It was shown that cytotoxic effect of NK cells can be to a certain extent related to the presence of secreting granules. A possible direct contribution of NK cell-synthesized hormones to the natural killer antitumour effect is discussed.
D000818:Animals; D003594:Cytoplasmic Granules / Q000378:metabolism* / Q000648:ultrastructure; D004723:Endorphins / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007694:Killer Cells, Natural / Q000378:metabolism* / Q000648:ultrastructure; D008550:Melatonin / Q000378:metabolism*; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D001615:beta-Endorphin
D004723:Endorphins; D012701:Serotonin; D001615:beta-Endorphin; D008550:Melatonin
Immunogistokhimicheskaia i élektronno-mikroskopicheskaia identifikatsiia serotonina, melatonina i beta-éndorfina v granulakh estestvennykh killerov.