[Mechanisms of action of beta-endorphin on the secretion of hypophyseal hormones].
The purpose of the study was to investigate some mechanisms of the effect of beta-endorphin on somatotropic and lactotropic function of the hypophysis, adrenal activity and the content of catecholamines in the cerebral tissues. Activation of the hypophyseoadrenal system, lactotropic and somatotropic functions 5-20 min after beta-endorphin administration was established in experiments on male rats. At the same time a decrease in the content of catecholamines in the hypothalamus, cerebral cortex was observed. It was most significant for dopamine participating in the regulation of ACTH, prolactin and somatotropin secretion.
D000305:Adrenal Cortex Hormones / Q000097:blood; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D004723:Endorphins / Q000494:pharmacology*; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D010907:Pituitary Hormones / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D001615:beta-Endorphin
D000305:Adrenal Cortex Hormones; D002395:Catecholamines; D004723:Endorphins; D010907:Pituitary Hormones; D001615:beta-Endorphin
Nekotorye mekhanizmy deĭstviia beta-éndorfina na sekretsiiu gipofizarnykh gormonov.