Electron microscopic autoradiographic study of heart muscle calcium in experimental cardiac glycoside poisoning.
The role of calcium was investigated in myocardial cell necrosis induced by cardiac glycoside. Experimental poisoning caused an increase of Ca45. Excessive intracellular calcium uptake must be the determining factor in the aetiology of myocardial cell damage. The possible involvement of calcium increase in the genesis of cardiac glycoside induced myocardial cell necrosis is discussed.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D004077:Digoxin / Q000633:toxicity*; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D009336:Necrosis; D011817:Rabbits
D004077:Digoxin; D000251:Adenosine Triphosphatases; D002118:Calcium