Synthesis and biological activity of some esters of the N-acetylglucosaminyl aglycone and of the aglycone of teicoplanin.
A series of ester derivatives of teicoplanin-N-acetylglucosaminyl aglycone (T-A3-2) and deglucoteicoplanin was prepared starting from teicoplanin and from the corresponding deglycosylation compounds. The modification of the ionic and lipophilic character of the parent antibiotic strongly influences the spectrum of antibacterial activity in vitro.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002264:Carboxylic Acids / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004951:Esterification; D004952:Esters / Q000138:chemical synthesis*; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects; D017334:Teicoplanin
D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D004952:Esters; D006020:Glycopeptides; D017334:Teicoplanin