title: Prolonged exercise causes an increase in the activity of galactosylhydroxylysyl glucosyltransferase and in the concentration of type III procollagen aminopropeptide in human serum.
abstract: The effect of prolonged heavy physical exercise on serum galactosylhydroxylysyl glucosyltransferase activity (S-GGT) and serum type III procollagen aminoterminal propeptide (S-Pro(III)-N-P) concentration was studied in healthy male long-distance runners. S-GGT increased gradually by about 70% (p less than 0.01) during a competitive 24-h run, and a rising trend was also observed in S-Pro(III)-N-P. After the termination of the run S-GGT was normalized in two days, but the increase in S-Pro(III)-N-P continued up to one day after the race, reaching nearly 40% (p less than 0.005). The alterations in S-GGT and S-Pro(III)-N-P showed no significant correlation with S-CK, S-LDH or the distance run. The most likely explanation for the increases in S-GGT and S-Pro(III)-N-P is that prolonged heavy exercise injures the collagen-synthesizing cells of the connective tissue, leading to a short-term increase in type III procollagen production.
mesh_terms: D000328:Adult; D001798:Blood Proteins / Q000032:analysis; D003094:Collagen / Q000096:biosynthesis; D003402:Creatine Kinase / Q000097:blood; D005964:Glucosyltransferases / Q000097:blood*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D009132:Muscles / Q000378:metabolism; D010446:Peptide Fragments / Q000097:blood*; D005082:Physical Exertion; D011347:Procollagen / Q000097:blood*; D012420:Running; D013997:Time Factors
chemical_list: D001798:Blood Proteins; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide; D003094:Collagen; D007770:L-Lactate Dehydrogenase; D005964:Glucosyltransferases; C023247:UDP glucose-collagen glucosyltransferase; D003402:Creatine Kinase