[Effect of beta-endorphin on catecholamine levels in the rat hypothalamus and cerebral cortex].
The present paper deals with the effect of beta-endorphin on catecholamine content in the hypothalamus and cerebral cortex of male rats. beta-endorphin was found to decrease catecholamine content in the rat brain, with the degree of reduction depending on the brain topography and the time following the peptide administration. 5 min later no changes in catecholamine content were observed either in the hypothalamus or in the cerebral cortex. 20 min later beta-endorphin induced a statistically significant fall of catecholamine concentration in the hypothalamus. A tendency towards its decrease was also observed in the cerebral cortex. 60 min later beta-endorphin produced an insignificant decrease in catecholamine level in both brain areas under study. It may be therefore suggested that beta-endorphin-induced decrease of catecholamine content in the hypothalamus and cerebral cortex represents one of the mechanisms underlying beta-endorphin stimulating action on a number of trophic functions of the hypophysis.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D004723:Endorphins / Q000494:pharmacology / Q000502:physiology*; D004837:Epinephrine / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D001615:beta-Endorphin
D002395:Catecholamines; D004723:Endorphins; D001615:beta-Endorphin; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
Vliianie beta-éndorfina na soderzhanie katekholaminov v gipotalamuse i kore bol'shikh polushariĭ krys.