title: Variation in the expression of macrophage Fc epsilon receptors in relation to experimental rat schistosome infection.
abstract: The relationship between IgE and rat peritoneal macrophages during the course of Schistosoma mansoni infection was examined. Immune macrophages exhibited an IgE-dependent schistosomulicidal activity mainly between the 5th and the 7th weeks. At this period the percentages of anti-IgE rosettes whose variations appeared consecutive to the variations in the serum IgE level were higher. Following incubation in a serum-free medium immune macrophages could release membrane-associated IgE, to a certain extent, and consequently formed rosettes with IgE-coated erythrocytes, indicating the existence of Fc epsilon receptors. Thus, in terms of rosettes, their number varied in the course of the disease. In fact IgE-rich serum (i.e. at day 42) as IgE molecules could induce this macrophage Fc epsilon receptor. Moreover when transferred to syngeneic rats in association with parasite-specific IgE Fc epsilon R2+ macrophages led to some protection against challenge infection. All the data reported here emphasize the determining role of macrophages and IgE in immunity to schistosomiasis.
mesh_terms: D000818:Animals; D006224:Cricetinae; D003602:Cytotoxicity, Immunologic; D005260:Female; D007116:Immunization, Passive; D007073:Immunoglobulin E / Q000032:analysis / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism* / Q000469:parasitology; D051379:Mice; D051381:Rats; D011916:Rats, Inbred F344; D011961:Receptors, Fc / Q000032:analysis* / Q000096:biosynthesis; D017455:Receptors, IgE; D012550:Schistosoma mansoni / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D013997:Time Factors
chemical_list: D011961:Receptors, Fc; D017455:Receptors, IgE; D007073:Immunoglobulin E