Quantitative autoradiographic localization of D-1 dopamine receptors in the rat brain: use of the iodinated ligand [125I]SCH 23982.
In vitro autoradiography was used to visualize [125I]SCH 23982 binding sites in rat brain. Labeling was concentrated in the caudate-putamen, accumbens nucleus, olfactory tubercle, substantia nigra pars reticulata and the entopeduncular nucleus. [125I]SCH 23982 labels predominantly D-1 receptors but also labels 5-HT2 receptors in certain areas of the brain. These findings may relate to the distribution of dopamine's cerebral loci of action on D-1 receptors.
D000818:Animals; D001345:Autoradiography; D001552:Benzazepines / Q000031:analogs & derivatives* / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D008024:Ligands; D008856:Microscopy, Fluorescence; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D017447:Receptors, Dopamine D1; D011985:Receptors, Serotonin / Q000378:metabolism
C049558:8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol; D001552:Benzazepines; D008024:Ligands; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D011985:Receptors, Serotonin; D004298:Dopamine