Exstrophy, epispadias, and cloacal and urogenital sinus abnormalities.
The congenital defects in the pelvis and perineal area, which are derived from defective development of the cloacal membrane, the urorectal septum, the mesonephric and paramesonephric (müllerian) ducts and the urogenital sinus, have been described. These may be life threatening, are often complex, and are certainly devastating to the parents. With knowledge of their embryologic origin, of their anatomy in detail, and the effect on function and drainage, treatment can be planned so that a good quality of life usually can be expected. Improved reconstructive programs and techniques can usually achieve near-normal appearance and function, with the expectation of good social adjustment.
D000009:Abdominal Muscles / Q000002:abnormalities*; D001746:Bladder Exstrophy / Q000150:complications / Q000196:embryology / Q000601:surgery; D004842:Epispadias / Q000150:complications / Q000196:embryology / Q000601:surgery; D005260:Female; D006554:Hernia, Umbilical / Q000150:complications / Q000196:embryology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007420:Intestine, Large / Q000002:abnormalities / Q000196:embryology / Q000601:surgery; D008297:Male; D010413:Penis / Q000002:abnormalities; D001743:Urinary Bladder / Q000002:abnormalities* / Q000196:embryology / Q000601:surgery; D014621:Vagina / Q000002:abnormalities