[Protective effects of Ginkgo biloba extract on the early rupture of the hemato-encephalic barrier in the rat].
During the hours immediately following an hypertensive burst or a cerebral ischemia induced by the intracarotid administration of microspheres, damage to the blood brain barrier can be observed with molecules of low molecular weight, such as angiotensin, whereas albumin or large proteins will not yet have been able to cross over and there is virtually no edema. Gingko biloba extract causes the brain uptake index of angiotensin hypertensive animals. This effect is proportional to the dose of extract used (500-100 mg/kg). A similar effect can be observed in animals showing embolism in one hemisphere. The process can therefore doubtlessly be explained by the stabilizing effect of Ginkgo biloba on membranes.
D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D012422:Rupture, Spontaneous; D014197:Trees
D010936:Plant Extracts; D000804:Angiotensin II
Effets protecteurs de l'extrait de Ginkgo biloba sur la rupture précoce de la barrière hémoencéphalique chez le rat.