Leukosialin, a major sialoglycoprotein on human leukocytes as differentiation antigens.
Most blood cells derived from the bone-marrow are known to possess only a limited number of heavily sialylated glycoproteins. We have recently isolated a major sialoglycoprotein on leukocytes and found that this glycoprotein, termed leukosialin, is ubiquitously present on various human leukocytes, granulocytes, monocytes/macrophages and T- and B-lymphocytes. Our studies showed that leukosialin is significantly glycosylated by O-linked oligosaccharides (90 chains/molecule). The structures of those O-linked oligosaccharides are characteristic to each cell lineage and maturation stage. The polypeptide portion of these molecules are, however, apparently the same, with a molecular size of 52 KDa. So it will be interesting to explore the possibility that leukosialin expresses different functions by having different O-glycosylation in a variety of hematopoietic cells.
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000032:analysis; D006801:Humans; D007951:Leukemia, Myeloid / Q000378:metabolism; D007962:Leukocytes / Q000032:analysis*; D051917:Leukosialin; D009844:Oligosaccharides / Q000032:analysis; D012795:Sialoglycoproteins / Q000032:analysis* / Q000302:isolation & purification / Q000502:physiology
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D051917:Leukosialin; D009844:Oligosaccharides; C465014:SPN protein, human; D012795:Sialoglycoproteins