Single oral dose pharmacokinetics of tiapride in patients with Huntington's disease.
The pharmacokinetic properties of a single oral dose of 100 mg of tiapride were studied in six patients with Huntington's disease. The results for five patients were consistent with a two compartment open model. Peak plasma concentrations were observed within 2 h following drug administration with a mean value of 0.92 micrograms/ml being recorded. The drug was rapidly eliminated as unmetabolised tiapride in the urine, 51% of the dose was recovered in 24 h. The plasma elimination half-life was 5.3 h and the average apparent plasma clearance was 16.6 l/h.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001549:Benzamides / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013976:Tiapamil Hydrochloride / Q000493:pharmacokinetics*
D001549:Benzamides; D013976:Tiapamil Hydrochloride