[Effect of chalone-containing aorta extracts on regression in experimental atherosclerosis].
The effect of chalone-containing aortic extracts on proliferative activity of smooth muscle cells was examined in conditions of experimental hypercholesterolemia. The tissue-specific cell proliferation inhibitor present in the extract is shown to depress mitotic activity of smooth muscle cells in postnatal rats. The area under aortic atherosclerotic lesion diminished twofold as compared to that of the controls. Morphologically, atherosclerotic changes are seen as lipid plaques.
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000473:pathology; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000473:pathology; D004036:Diet, Atherogenic; D004353:Drug Evaluation, Preclinical; D006131:Growth Inhibitors / Q000627:therapeutic use*; D008938:Mitosis / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000473:pathology; D011817:Rabbits; D051381:Rats; D013997:Time Factors; D014020:Tissue Extracts / Q000627:therapeutic use*
D006131:Growth Inhibitors; D014020:Tissue Extracts
Vliianie keĭlonsoderzhashchikh ékstraktov aorty na regressiiu éksperimental'nogo ateroskleroza.