Placebo response rates in psychotic and nonpsychotic depression.
The authors reanalyzed data from two earlier studies that used double-blind placebo-controlled formats to study the efficacy of amitriptyline. Using a 14-day drug-free 'wash-out' period, they found that the placebo response rates were 0% for psychotic depressives and 13.3% for nonpsychotic depressives. Amitriptyline was significantly superior to placebo for both psychotic (P less than or equal to 0.05) and nonpsychotic (P less than or equal to 0.05) depressed patients.
D000639:Amitriptyline / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003702:Delusions / Q000188:drug therapy; D003866:Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D006801:Humans; D010919:Placebos / Q000627:therapeutic use*; D011581:Psychological Tests; D011618:Psychotic Disorders / Q000188:drug therapy*; D011897:Random Allocation
D010919:Placebos; D000639:Amitriptyline