Chronic amphetamine treatment increases striatal calmodulin in rats.
A radioimmunoassay was developed to measure calmodulin in striatum from rats treated with one dose or repeated injections of amphetamine. Chronic, but not acute, amphetamine treatment resulted in a significant increase in total calmodulin levels in striatal homogenates. This effect may be linked to the behavioral sensitization which develops after chronic amphetamine treatments.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D002147:Calmodulin / Q000032:analysis*; D003342:Corpus Striatum / Q000032:analysis / Q000187:drug effects*; D005260:Female; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism; D017448:Receptors, Dopamine D2; D013268:Stimulation, Chemical
D002147:Calmodulin; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D000661:Amphetamine