Modulation of human T-cell suppressor activity by beta endorphin and glycyl-L-glutamine.
beta-endorphin (10(-7) M) induced suppressor cell activity in human peripheral blood lymphocyte cultures comparable to that of concanavalin A (Con A) (60 micrograms/ml). beta-endorphin and Con A, when used together during the induction portion of the suppressor assays, displayed synergistic activity. In contrast, glycyl-L-glutamine, the carboxy terminal dipeptide of beta-endorphin, inhibited development of Con A induced suppressor activity. It appears that the previously reported suppressive effects of beta-endorphin on immune function may be achieved by activation of specific suppressor T cell populations.
D003208:Concanavalin A; D004261:DNA Replication / Q000187:drug effects; D004151:Dipeptides / Q000494:pharmacology*; D004723:Endorphins / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*; D001615:beta-Endorphin
D004151:Dipeptides; D004723:Endorphins; D003208:Concanavalin A; C039788:glycylglutamine; D001615:beta-Endorphin