2-Mercaptopropionylglycine and related compounds in treatment of mitochondrial dysfunction and postischemic myocardial damage.
Reversal of mitochondrial dysfunction caused by uncouplers of oxidative phosphorylation, diamide, ageing and ischemia was studied using 2-mercaptopropionylglycine (MPG) in reduced and oxidized (ox-MPG) forms and other SH compounds. Rat heart mitochondria and mitochondrial ATPase, OS-ATPase from beef heart and the isolated working rat heart preparation were examined. MPG and ox-MPG partly prevented and reversed mitochondrial uncoupling and improved deteriorated heart function. ATPase activities were decreased by MPG and ox-MPG in both types of preparation. Three mechanisms are probably involved in thiol action. These comprise alternatively and/or additively: a) SH/S-S interchange reactions; b) free radical scavenger function; c) polar-polar (apolar) interactions. This may contribute to improve oxidative phosphorylation which is considered as a result of recoupling damaged mitochondria by MPG.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000375:Aging; D000603:Amino Acids, Sulfur / Q000627:therapeutic use*; D000818:Animals; D002417:Cattle; D003327:Coronary Disease / Q000188:drug therapy*; D003958:Diamide / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000627:therapeutic use*; D008625:Tiopronin / Q000627:therapeutic use*; D014475:Uncoupling Agents / Q000494:pharmacology
D000603:Amino Acids, Sulfur; D013438:Sulfhydryl Compounds; D014475:Uncoupling Agents; D003958:Diamide; D008625:Tiopronin; D000251:Adenosine Triphosphatases