Deficiency of phenotypic cytotoxic-suppressor T lymphocytes in the BB/W rat.
The BB/W rat is currently the best model of type I (insulin dependent diabetes). Even though this rat develops an autoimmune disease, they are immune deficient. In this study we have demonstrated the almost complete absence of the OX 8+, OX 19+ T cytotoxic/suppressor population in diabetes prone and acute diabetic rats. This population is present in the diabetes resistant W line. The diabetes prone and acute diabetic rats have a relative increase in OX 8+, OX 19- natural killer (NK) cells. Our data suggests that virtually all OX 8+ cells in diabetes prone and acute diabetic animals are phenotypic NK cells.
D000208:Acute Disease; D000818:Animals; D000911:Antibodies, Monoclonal; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D004195:Disease Models, Animal; D005434:Flow Cytometry; D007694:Killer Cells, Natural / Q000145:classification; D008231:Lymphopenia / Q000276:immunology*; D010641:Phenotype; D051381:Rats; D011913:Rats, Inbred BB / Q000276:immunology*; D011919:Rats, Inbred Strains / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000911:Antibodies, Monoclonal