Arachidonic acid metabolism of human granulocytes from asthmatic patients.
Granulocytes from asthmatic patients produced more LTC4 than did normal granulocytes on calcium ionophore stimulation. When granulocytes were stimulated, the rate of increase of AA metabolite participating in bronchospasm was significantly higher in asthmatic granulocyte than in normals; however, the rates of increase in bronchodilating metabolite showed no difference. After stimulation, the total amounts of AA metabolites in asthmatic granulocytes and normal granulocytes showed no difference; however, the ratio between bronchodilating AA metabolites and bronchoconstricting AA metabolites was higher in asthmatic granulocytes.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood*; D001249:Asthma / Q000097:blood*; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D011453:Prostaglandins / Q000097:blood; D012016:Reference Values
D001095:Arachidonic Acids; D011453:Prostaglandins; D016718:Arachidonic Acid