title: Immunologic studies in identical twins concordant for juvenile rheumatoid arthritis but discordant for monoclonal gammopathy and amyloidosis.
abstract: Identical twins concordant for juvenile rheumatoid arthritis but discordant for monoclonal gammopathy and amyloidosis were the subjects of a study done with mixed leukocyte culture, anti-idiotypic antisera against serum and urinary M component from the amyloid-affected twin, and in vitro estimations of M-component idiotype synthesis by peripheral blood mononuclear cells. Immunohistochemical analysis of renal amyloid deposits in the affected twin showed AL amyloid of the lambda-II variable region subgroup. M-component idiotypes were confined only to the twin with serum and urine M components.
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000032:analysis; D000682:Amyloid / Q000378:metabolism; D000686:Amyloidosis / Q000150:complications / Q000276:immunology*; D000954:Antigens, Surface / Q000032:analysis; D001171:Arthritis, Juvenile / Q000150:complications / Q000276:immunology*; D001536:Bence Jones Protein / Q000235:genetics; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000032:analysis; D007668:Kidney / Q000378:metabolism; D007959:Lymphocyte Culture Test, Mixed; D010265:Paraproteinemias / Q000150:complications / Q000276:immunology*; D014427:Twins; D014430:Twins, Monozygotic
chemical_list: D000596:Amino Acids; D000682:Amyloid; D000954:Antigens, Surface; D007130:Immunoglobulin Idiotypes; D001536:Bence Jones Protein