title: [Clinical prevention of esophageal cancer].
abstract: An effective method of complex treatment of reflux-esophagitis with reparation stimulants (methyluracil) was developed to improve clinical prophylaxis of esophageal cancer. Application of the said method was followed by a 3-5-fold increase in "clinical recovery" rate, slower advancement of pathologic changes in the esophageal epithelium thus lowering the risk of neoplasia. Within 5 years of dynamic follow-up, patients with esophagitis exposed to the above treatment showed a 4-fold decrease in risk for cancer. A special program of screening for esophagitis, its treatment and patients' follow-up is discussed.
mesh_terms: D003131:Combined Modality Therapy / Q000379:methods; D004938:Esophageal Neoplasms / Q000209:etiology / Q000517:prevention & control*; D004942:Esophagitis, Peptic / Q000150:complications / Q000473:pathology / Q000628:therapy; D004945:Esophagoscopy; D004947:Esophagus / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007623:Kazakhstan; D007971:Leukoplakia / Q000473:pathology / Q000628:therapy; D008403:Mass Screening; D011230:Precancerous Conditions / Q000473:pathology / Q000628:therapy; D012306:Risk; D013997:Time Factors; D014498:Uracil / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D014498:Uracil; C008378:6-methyluracil
vernacular_title: Klinicheskaia profilaktika raka pishchevoda.