title: Increased activity of four glycolytic enzymes in cultured fibroblasts from cystic fibrosis patients.
abstract: The mean levels of activity of hexokinase, phosphofructokinase, pyruvate kinase and lactate dehydrogenase were found to be significantly higher in fibroblasts from cystic fibrosis patients than in those from age-matched controls and heterozygotes. This indicates that the activity of the glycolytic pathway is increased in fibroblasts from cystic fibrosis patients.
mesh_terms: D002478:Cells, Cultured; D003550:Cystic Fibrosis / Q000201:enzymology* / Q000235:genetics; D005347:Fibroblasts; D006019:Glycolysis; D006579:Heterozygote; D006593:Hexokinase / Q000378:metabolism; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D010732:Phosphofructokinase-1 / Q000378:metabolism; D011770:Pyruvate Kinase / Q000378:metabolism
chemical_list: D007770:L-Lactate Dehydrogenase; D006593:Hexokinase; D010732:Phosphofructokinase-1; D011770:Pyruvate Kinase