[Stimulation of the suppressor activity in relation to hematopoietic cells in the mouse thymus as affected by pertussis vaccine].
After a single intraperitoneal injection of formalinized whole-cell pertussis vaccine 5374 into CBA mice a drastic depletion of cells in the thymus accompanied by the enhancement of suppressor T-cells production is observed. T-cells inhibit the endogenous and exogenous colony-formation in the spleen by hematopoietic stem cells (CFUs). Treatment of thymus cells with the anti-I-Jk alloantiserum against a specific marker of suppressor T-cells in the presence of complement removes the inhibitory effect on CFUs proliferation and has a stimulatory action on the capacity of the marrow CFUs to form macroscopic hematopoietic colonies in the spleen compared with control ones. These results suggest probable involvement of I-J-bearing suppressor T-cells in the hematopoietic disorders induced by pertussis vaccine.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D001854:Bone Marrow Cells; D003114:Colony-Forming Units Assay; D005260:Female; D005720:Gamma Rays; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D007114:Immunization; D008213:Lymphocyte Activation / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000276:immunology / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000528:radiation effects; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D013997:Time Factors
D010567:Pertussis Vaccine
Stimuliatsiia supressornoĭ aktivnosti po otnosheniiu k krovetvornym kletkam v timuse mysheĭ pod deĭstviem kokliushnoĭ vaktsiny.