title: Mood-altering effects of biperiden in healthy volunteers.
abstract: There has been considerable evidence that, aside from various other effects, synthetic anticholinergics also possess a significant euphoriant property. A double-blind placebo-controlled study was conducted in an attempt to answer the following questions: Can euphoria be induced by experimental intravenous administration of biperiden in therapeutic dosages? Is the individual's psychic response to anticholinergics associated with particular personality traits? In a study with a double-blind placebo cross-over design 28 healthy volunteers were given biperiden intravenously. The evaluation of their reaction to the drug using the Bech-Rafaelsen Mania Scale (MRS) revealed two groups of about the same numerical size demonstrating a considerable difference in their reaction to the drug.
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects; D001712:Biperiden / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004644:Emotions / Q000187:drug effects*; D005059:Euphoria / Q000187:drug effects; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008950:MMPI; D008297:Male; D010880:Piperidines / Q000494:pharmacology*
chemical_list: D010880:Piperidines; D001712:Biperiden