title: Atrial natriuretic factor-SV40 T antigen transgenes produce tumors and cardiac arrhythmias in mice.
abstract: Transgenic mice that carry fusions between the transcriptional regulatory sequences of atrial natriuretic factor (a hormone intimately involved in the regulation of blood pressure) and those encoding SV40 T antigen (an oncoprotein) were generated. Although both atria express the fusion gene, the pathological response to T antigen is asymmetrical. The right atrium undergoes a several hundredfold increase in mass while the left atrium remains relatively normal in size. Hyperplasia is accompanied by a progressive increase in both the frequency and severity of abnormalities in the atrial conduction system, which ultimately result in death.
mesh_terms: D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics*; D001145:Arrhythmias, Cardiac / Q000235:genetics* / Q000503:physiopathology; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D004274:DNA, Recombinant; D004562:Electrocardiography; D004594:Electrophysiology; D005809:Genes, Regulator; D006325:Heart Atria / Q000473:pathology / Q000503:physiopathology; D006329:Heart Conduction System / Q000503:physiopathology; D006338:Heart Neoplasms / Q000235:genetics* / Q000503:physiopathology; D006965:Hyperplasia; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008822:Mice, Transgenic; D009857:Oncogenes; D011401:Promoter Regions, Genetic
chemical_list: D000952:Antigens, Polyomavirus Transforming; D004274:DNA, Recombinant; D009320:Atrial Natriuretic Factor