[Significance of Fc receptors for IgG].
Fc gamma R are glycoproteins or phospholipoproteins respectively. Their molecular weight depends on type and origin of the Fc gamma R-coated cell and was determined between 40 and 115 KD. Fc gamma R can be estimated by means of rosetting assay or binding experiments with isotopic or fluorescein labeled immune complexes or aggregated IgG respectively. Depending on the cell type Fc gamma R are involved in different reactions after respective binding of their ligands. A lot of results are described in the literature, indicating that Fc gamma R bearing T lymphocytes are suppressor cells in the humoral immune response, but generally accepted data about the involvement of Fc gamma R in this suppression do not exist. Some models are represented in this paper.
D006801:Humans; D007108:Immune Tolerance; D007074:Immunoglobulin G / Q000502:physiology*; D008264:Macrophages / Q000276:immunology; D011961:Receptors, Fc / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D007074:Immunoglobulin G; D011961:Receptors, Fc
Zur Bedeutung von Fc-Rezeptoren für IgG.