[Effect of PIND-AVI on various ratios of helper and suppressor T lymphocytes].
The immunomodulating effect of a new heterologous antigen (PIND-AVI) on helper (inducer) and suppressor T cells was investigated. Primarily decreased T4 values (less than or equal to mean T4 - 2 S.D.) increased after treatment with PIND (P less than 0.005, using Student's t-test; n = 15). Primarily increased T 8 values (greater than or equal to mean T8 + 2 S.D.; obtained for normal persons) decreased after therapy (P less than 0.001; n = 10). An increase of T4/T8 ratio (P less than 0.005 and less than 0.001) to normal values was observed in both cases. T4 and T8 values within the mean +/- 2 S.D. were not influenced significantly (n = 13). In spite of different primary values, the amount of lymphocytes/mm3 was not significantly influenced. It appears advisable to check the results of treatment continuously every few weeks.
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000276:immunology; D001688:Biological Products / Q000494:pharmacology*; D005260:Female; D006561:Herpes Simplex / Q000276:immunology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology
D001688:Biological Products; C028621:PIND-AVI
Einfluss von PIND-AVI auf unterschiedliche Ausgangsverhältnisse von Helfer- und Suppressor-T-Lymphozyten.