Histamine-induced suppressor cell function and nasal sensitivity in hay fever sufferers.
Histamine-induced suppressor cell function was measured in a group of twenty-five hay fever suffers and sixteen non-atopic controls. No difference was found in the suppression index between sufferers and controls. There was, however, a significant relationship between the suppression index and nasal sensitivity to grass pollen, whether measured pre- or post-season, but no correlation between specific or total IgE levels and the suppression index. Histamine-induced suppressor cell function may influence pollen sensitivity in the most sensitive subjects, but not via an effect on IgE production.
D000293:Adolescent; D000328:Adult; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008297:Male; D009299:Nasal Provocation Tests; D037121:Plant Lectins; D011058:Pollen / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology
D037121:Plant Lectins; D003208:Concanavalin A; D007073:Immunoglobulin E; D006632:Histamine