title: Penetration of mucopolysaccharides into the skin of diverse animal species.
abstract: The penetration of mucopolysaccharide polysulfuric acid ester (MPS, Hirudoid) into the skin could be demonstrated in various animal species by means of a special histochemical technique. Deposition of MPS in the nude mouse, rat, guinea pig, rabbit and pig can be demonstrated by metachromatic staining of cellular elements of the corium and subcutis. Species-specific differences in the infiltrative behavior of the test substance become apparent, dependent not only on the utilized pharmaceutical preparation but also on the particular skin morphology.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism*; D006168:Guinea Pigs; D006651:Histocytochemistry; D008297:Male; D051379:Mice; D008819:Mice, Nude; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000166:cytology / Q000378:metabolism*; D012869:Skin Absorption; D013045:Species Specificity; D013552:Swine
chemical_list: D006025:Glycosaminoglycans