title: The pharmacokinetics and tissue penetration of teicoplanin.
abstract: The pharmacokinetics of teicoplanin were studied following a 440 mg intravenous dose in six male volunteers. The levels of the compound were measured in serum, blister fluid and urine. The mean serum level 0.5 h after injection was 44.6 mg/l falling to 3.6 mg/l at 49 h. The elimination half-life of teicoplanin from serum was 34.2 h and the apparent distribution half-life 1.5 h. Penetration into blister fluid was moderately fast, the mean maximum concentration (14.8 mg/l) occurring at 2.7 h, and the mean percentage penetration being 77.4%. Urinary recovery of the drug was 48.3% by 96 h.
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001768:Blister / Q000378:metabolism; D006020:Glycopeptides / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D017334:Teicoplanin
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D017334:Teicoplanin