Detection of brain autoantibodies in the serum of patients with Alzheimer's disease but not Down's syndrome.
The immunofluorescent staining of antibodies specifically binding to rat brain tissue sections was investigated in 95 human sera including 30 cases of Alzheimer's disease. A high incidence of specific antibrain antibody was found among Alzheimer's patients (57% positive) compared to other neurological disease controls (only 8% positive) or normal young and aged healthy controls (none positive).
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000276:immunology*; D001323:Autoantibodies / Q000302:isolation & purification*; D001921:Brain / Q000276:immunology*; D004314:Down Syndrome / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology; D010300:Parkinson Disease / Q000276:immunology; D012559:Schizophrenia / Q000276:immunology
D001323:Autoantibodies