Unexplained thromboembolism. When to suspect antithrombin III, protein C, or protein S deficiency.
Patients with recurrent or unusual thromboembolic events may have abnormalities in regulation of hemostasis because of inherited or acquired deficiencies of antithrombin III, protein C, or protein S. A working knowledge of the clotting process and a high degree of suspicion are needed to guide the clinician in this difficult diagnosis. Prompt and appropriate anticoagulant therapy can be lifesaving in these patients.
D020152:Antithrombin III Deficiency; D006023:Glycoproteins / Q000172:deficiency*; D006801:Humans; D020151:Protein C Deficiency; D017293:Protein S; D013923:Thromboembolism / Q000378:metabolism* / Q000628:therapy
D006023:Glycoproteins; D017293:Protein S