Comparative in vitro activity of seven quinolones against 100 clinical isolates of Clostridium difficile.
The in vitro activity of seven quinolone derivatives against 100 clinical isolates of Clostridium difficile was determined. CI934 was the most active, inhibiting 90% of the strains at 4 micrograms/ml and 100% at 8 micrograms/ml. Ofloxacin and ciprofloxacin had moderate activity (16 and 32 micrograms/ml) whereas enoxacin, pefloxacin, norfloxacin, and nalidixic acid had poor activity (128 micrograms/ml).
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002939:Ciprofloxacin; D003013:Clostridium / Q000145:classification / Q000187:drug effects*; D015365:Enoxacin; D024841:Fluoroquinolones; D006801:Humans; D007231:Infant, Newborn; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology; D009287:Naphthyridines / Q000494:pharmacology; D009643:Norfloxacin / Q000031:analogs & derivatives / Q000494:pharmacology; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology; D015366:Pefloxacin; D011804:Quinolines / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D010078:Oxazines; D011804:Quinolines; D015366:Pefloxacin; D015365:Enoxacin; D009268:Nalidixic Acid; D002939:Ciprofloxacin; C047718:CI 934; D015242:Ofloxacin; D009643:Norfloxacin