The relationship of soluble immune complexes, insulin antibodies and insulin-anti-insulin complexes to platelet and coagulation factors in type 1 diabetic patients with and without proliferative retinopathy.
The possible correlation between soluble immune factors and platelet and coagulation factors has been evaluated in Type 1 diabetic patients with and without proliferative retinopathy, and in non-diabetic controls. Soluble immune complexes, platelet factor IV (PF4), beta-thromboglobulin, fibrinogen, factor VIII related antigen and anti-thrombin III were significantly increased in Type 1 diabetic patients with retinopathy as compared to non-diabetic controls. Fibrinogen and anti-thrombin III were also higher in those patients with retinopathy compared to those without retinopathy. A significant correlation was found between positive values of soluble immune complexes and increased levels of PF4 and beta-thromboglobulin in diabetic patients with retinopathy. The presence of soluble immune complexes and insulin-anti-insulin complexes was associated with a significantly greater number of elevated haemostatic factors in retinopathic patients. Our findings suggest that the interaction of platelets and soluble immune complexes or insulin-anti-insulin complexes may be pathologically relevant to the development of diabetic retinopathy.
D000328:Adult; D000936:Antigen-Antibody Complex / Q000276:immunology*; D000990:Antithrombin III / Q000378:metabolism; D001779:Blood Coagulation Factors / Q000652:urine*; D001792:Blood Platelets / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D003930:Diabetic Retinopathy / Q000276:immunology*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007330:Insulin Antibodies / Q000276:immunology*; D008297:Male; D010978:Platelet Factor 4 / Q000378:metabolism; D001620:beta-Thromboglobulin / Q000378:metabolism
D000936:Antigen-Antibody Complex; D001779:Blood Coagulation Factors; D007074:Immunoglobulin G; D007330:Insulin Antibodies; D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; D000990:Antithrombin III; D005340:Fibrinogen