title: Acquired perforating disease in oil field workers.
abstract: Eight cases of an acquired perforating disease are reported in oil field workers who were exposed to drilling fluid. Analysis of the drilling fluid showed it to contain many components, including calcium chloride. Histopathologic study of patient lesions demonstrated transepidermal elimination of calcium. An in vivo mouse model was developed to study this phenomenon, which may represent a calcium-mediated perforating disorder.
mesh_terms: D000328:Adult; D000818:Animals; D002057:Burns, Chemical / Q000209:etiology* / Q000473:pathology; D002122:Calcium Chloride / Q000009:adverse effects; D002424:Caustics / Q000009:adverse effects*; D009783:Dermatitis, Occupational / Q000139:chemically induced* / Q000473:pathology; D005579:Fossil Fuels; D006801:Humans; D008297:Male; D051379:Mice; D009790:Occupations; D012867:Skin / Q000293:injuries* / Q000473:pathology
chemical_list: D002424:Caustics; D005579:Fossil Fuels; D002122:Calcium Chloride