Single dose comparison of salbutamol and a fenoterol/ipratropium combination from metered aerosols in patients with asthma.
The single dose spirometric response to a combination metered aerosol product, fenoterol/ipratropium was compared with salbutamol from a metered aerosol in ten stable asthmatics. Two puffs from the combination aerosol (fenoterol 100 micrograms and ipratropium bromide 40 micrograms/puff) were compared with two puffs of salbutamol (100 micrograms/puff). The study was a cross-over design, using a double dummy technique and was placebo controlled. All subjects had demonstrated prior reversibility and baseline FEV1, values were within 15% on each study day.
D000328:Adult; D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001286:Atropine Derivatives / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage*; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012129:Respiratory Function Tests
D000336:Aerosols; D001286:Atropine Derivatives; D005280:Fenoterol; D009241:Ipratropium; D000420:Albuterol