title: The enzymatic degradation of polymers in vitro.
abstract: Specimens of 14C-labeled poly(ethylene terephthalate), nylon 66, and poly(methyl methacrylate) have been synthesized and exposed, in vitro, to a number of enzyme solutions. Poly(ethylene terephthalate) was found to be affected by esterase and papain, although in different ways, but not by trypsin or chymotrypsin. Nylon 66 was unaffected by esterase but degraded by the other three. Poly(methyl methacrylate) was not affected by any of these enzymes. This indicates that some nominally stable polymers are susceptible to degradation by enzymes under some circumstances. The amount of degradation is small, but could have significant sequelae should it be reproduced in vivo.
mesh_terms: D002918:Chymotrypsin; D004950:Esterases / Q000378:metabolism*; D009757:Nylons; D010206:Papain; D011093:Polyethylene Terephthalates; D011109:Polymethacrylic Acids; D013997:Time Factors; D014357:Trypsin
chemical_list: D009757:Nylons; D011093:Polyethylene Terephthalates; D011109:Polymethacrylic Acids; D004950:Esterases; D002918:Chymotrypsin; D014357:Trypsin; D010206:Papain