[Effects of Ginkgo biloba extract on a cerebral ischemia model in gerbils].
Certain anatomical characteristics peculiar to the gerbil make it the animal model best adapted to experimental pathology studies of acute ischaemia. In this animal species, devoid of any substitute vertebro-basilar vascular tissue, unilateral ligature of the carotid artery produces a cerebral ischaemia with neurological signs (well quantifiable), metabolic perturbations (especially mitochondrial) and cerebral oedema development closely resembling the symptoms revealed by physiopathology in human clinical studies. Using this model and under the experimental conditions described, clear-cut, highly significant results were obtained with Ginkgo biloba, whether by oral or intravenous administration. These results were normalization of mitochondrial respiration, diminution of cerebral oedema, correction of the accompanying ionic perturbations, and practically total functional restoration revealed by a normal neurological index in the gerbils treated with Ginkgo biloba extract.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005849:Gerbillinae; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009530:Nicergoline / Q000627:therapeutic use; D010101:Oxygen Consumption / Q000187:drug effects; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D014197:Trees; D014749:Vincamine / Q000627:therapeutic use
D010936:Plant Extracts; D014749:Vincamine; D009530:Nicergoline
Effets de l'extrait de Ginkgo biloba sur un modèle d'ischémie cérébrale chez la gerbille.