The effect of GR38032F, novel 5-HT3-receptor antagonist on gastric emptying in the guinea-pig.
The effects of GR38032F a novel, selective and potent 5-hydroxytryptamine (5-HT3)-receptor antagonist on gastric emptying in the guinea-pig were investigated and compared to those of metoclopramide and haloperidol. Both GR38032F and metoclopramide increased gastric emptying in a dose-dependent manner. In contrast, haloperidol was ineffective. GR38032F was about 200 times more potent than metoclopramide in enhancing gastric emptying over the 2 h period studied.
D000818:Animals; D005746:Gastric Emptying / Q000187:drug effects*; D006168:Guinea Pigs; D006220:Haloperidol / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D008787:Metoclopramide / Q000494:pharmacology; D017294:Ondansetron; D012702:Serotonin Antagonists / Q000494:pharmacology*
D007093:Imidazoles; D012702:Serotonin Antagonists; D017294:Ondansetron; D006220:Haloperidol; D008787:Metoclopramide