Lymphocyte subsets in the young and aging marmoset (Callithrix jacchus).
T lymphocytes were studied in healthy young and old marmosets (Callithrix jacchus). Data indicate that monoclonal antisera to human T lymphocyte antigens can be used to identify these cells in marmosets. Total T and suppressor T cells were lower in the older group; there were no differences in helper T or in B cells. Helper/suppressor ratios (T4/T8) were increased in the older group. Thus, immune system alternations with aging and/or immune deficiency syndromes may be studied in this animal model using available reagents.
D000375:Aging; D000818:Animals; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes; D002144:Callithrix / Q000097:blood / Q000276:immunology*; D002143:Callitrichinae / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D007958:Leukocyte Count; D012397:Rosette Formation; D013601:T-Lymphocytes; D013602:T-Lymphocytes, Cytotoxic; D006377:T-Lymphocytes, Helper-Inducer; D050378:T-Lymphocytes, Regulatory
D000911:Antibodies, Monoclonal