[Comparative effect of opioid receptor ligands on cell division in the epithelium of the tongue in white rats].
Beta-endorphin, leu-enkephalin, dalargin and naloxone influences on cell division have been studied in tongue epithelium of white rats. The preparations were administered at a dose of 0.1 ml per 100 g body weight as a 2.10(-9) M solution. Cell division was studied 24 hours after administration. beta-endorphin, leu-enkephalin, dalargin and naloxone caused a 1.5-1.7-fold increase in the number of DNA-synthesizing nuclei, which was accompanied by an adequate rise in mitotic index in experiments with dalargin.
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D014059:Tongue / Q000187:drug effects; D001615:beta-Endorphin / Q000494:pharmacology*
D009270:Naloxone; D004743:Enkephalin, Leucine; D001615:beta-Endorphin; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Izuchenie sravnitel'nogo vliianiia razlichnykh ligandov opioidnykh retseptorov na protsessy kletochnogo deleniia épiteliia iazyka belykh krys.