[Persistence of the circadian rhythm of dehydroepiandrosterone in the brain, but not in the plasma, of castrated and adrenalectomized rats].
In adrenalectomized and orchidectomized rats, the removal of the steroidogenic endocrine glands is associated with a near-disappearance of corticosterone (B) from plasma and brain; circadian variations of B and of plasma dehydroepiandrosterone (D), characteristic of the intact rat, are no more detected. By contrast, analyses of brain D measurements by the cosinor method demonstrate a persisting circadian rhythm of large amplitude.
D000315:Adrenalectomy; D000818:Animals; D001921:Brain / Q000502:physiology*; D002940:Circadian Rhythm; D003687:Dehydroepiandrosterone / Q000097:blood / Q000378:metabolism*; D008297:Male; D009919:Orchiectomy; D051381:Rats; D011919:Rats, Inbred Strains
D003687:Dehydroepiandrosterone
Persistance d'un rythme circadien de la déhydroépiandrostérone dans le cerveau, mais non dans le plasma, de rats castrés et surrénalectomisés.