Free amino acids in cytosol of rat brain after intraventricular administration of 5,6-dihydroxytryptamine and 6-hydroxydopamine.
Levels of 24 free amino acids were estimated in the brain after administration of 5,6-dihydroxytryptamine and 6-hydroxydopamine into the lateral brain ventricles of male Wistar rats. These neurotransmitters caused serotoninectomy and sympathectomy in the diencephalon, striatum, brain stem and medulla, thalamus and hypothalamus, cerebral cortex and cerebellum. The most abundant amino acids in these brain structures were: glutamic acid, serine, aspartic acid, cystine, gamma-aminobutyric acid, glycine, tryptophan and alanine. We detected and quantified changes in the levels of these and other amino acids in the investigated regions of the rat central nervous system, under the influence of these two neurotransmitters.
D015115:5,6-Dihydroxytryptamine / Q000008:administration & dosage / Q000494:pharmacology*; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000378:metabolism*; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009928:Organ Specificity; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D006892:Hydroxydopamines; D016627:Oxidopamine; D015115:5,6-Dihydroxytryptamine