Development of T-cell function in relation to T-cell set diversification in nu/nu mice.
The differentiation pattern of splenic T-cell populations in germ- and pathogen-free nu/nu mice, as compared to nu/+ littermates, is characterized by two abnormal features: the expression of TL determinants on peripheral T cells and the delayed onset of their differentiation from the predominant Lyt-123:TL+ set into TL- cells of Lyt-1+ and Lyt-123+ phenotype, which, in these mice, does not occur until 10 weeks of age. We report here that the delayed onset of mitogen- or alloantigen-induced interleukin-2 synthesis and T-cell proliferation as well as the development of cytotoxic T-lymphocyte activity of enriched T-cell populations is strictly correlated with the time point of T-cell subset diversification in nu/nu mice and depends in particular on the presence of the Lyt-1 (TL-:Lyt-2-) T-cell set which is lacking in splenic T-cell populations of germ-free young nu/nu mice.
D000367:Age Factors; D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D007375:Interleukin-1; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D051379:Mice; D008819:Mice, Nude; D010446:Peptide Fragments / Q000494:pharmacology; D010641:Phenotype; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000502:physiology; D016305:Thymopentin; D013946:Thymopoietins / Q000494:pharmacology
D007375:Interleukin-1; D007376:Interleukin-2; D010446:Peptide Fragments; D013946:Thymopoietins; D003208:Concanavalin A; D016305:Thymopentin