title: Aetiology of pulmonary dysfunction in total hip replacement operations. The influence of nifedipine on the factors involved.
abstract: Patients undergoing total hip replacement surgery who developed pulmonary dysfunction (PD) demonstrated evidence of complement activation and increased thromboxane A2 (TXA2) synthesis. In a double-blind study nifedipine (Adalat; Bayer-Miles) was shown to inhibit complement activation and TXA2 synthesis and thus appears to offer protection against PD.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002986:Clinical Trials as Topic; D003182:Complement C5 / Q000032:analysis; D004311:Double-Blind Method; D011464:Epoprostenol / Q000097:blood; D005260:Female; D006621:Hip Joint / Q000601:surgery; D006622:Hip Prosthesis; D006801:Humans; D007432:Intraoperative Period; D008171:Lung Diseases / Q000209:etiology* / Q000378:metabolism; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use*; D011183:Postoperative Complications; D011184:Postoperative Period; D011897:Random Allocation; D013928:Thromboxane A2 / Q000097:blood; D001620:beta-Thromboglobulin / Q000032:analysis
chemical_list: D003182:Complement C5; D001620:beta-Thromboglobulin; D013928:Thromboxane A2; D011464:Epoprostenol; D009543:Nifedipine