title: [Effects of exercise on coronary circulation in left ventricular hypertrophy caused by hypertension].
abstract: Exercise is known to promote myocardial vascularity. We therefore studied whether it could prevent coronary abnormalities of hypertensive left ventricular (LV) hypertrophy. Female Sprague-Dawley 1 clip-2 kidneys Goldblatt hypertensive rats (RHR) and their appropriate controls (Sham-SH), were either made to swim (RHR-SW, SH-SW) or kept sedentary (RHR-SED, SH-SED) for 9 weeks. Maximal coronary blood flow (LV CBF, ml/min/gm) and minimal coronary resistance after carbochrome (total LVCR/LV mmHg/ml/min), an index of the functional cross sectional area (CSA) of coronary resistance vessels, were determined in conscious rats by microspheres. Results (m +/- SD) (n = 12 in all groups): (Table: see text). Exercise increased functional coronary CSA in normotensive rats only. This beneficial effect did not occur in hypertension, probably because of functional changes in the coronary vessels of RHR.
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000209:etiology / Q000503:physiopathology*; D002866:Chromonar; D003326:Coronary Circulation; D005260:Female; D006352:Heart Ventricles; D006973:Hypertension / Q000150:complications*; D009929:Organ Size; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002866:Chromonar
vernacular_title: Effets de l'exercice sur la circulation coronaire dans l'hypertrophie ventriculaire gauche par hypertension artérielle.