title: The relative roles of genetic and environmental factors in the regulation of erythrocyte C3b receptor (ECR1) numbers in normal individuals.
abstract: Erythrocyte C3b receptors (ECR1) have been measured in 122 pairs of twins (60 monozygotic, 62 dizygotic) using an [125I]-labelled monoclonal antibody (E11). The range of ECR1 numbers was wide, 99-4179 sites/cell, with a log-normal distribution around a geometric mean of 837 sites/cell. The intra-pair variance in dizygotic twins was no greater than that in monozygotic twins. These data indicate that ECR1 numerical expression is governed by environmental rather than genetic factors.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004777:Environment; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011951:Receptors, Complement / Q000032:analysis / Q000235:genetics*; D017463:Receptors, Complement 3b; D012016:Reference Values; D014427:Twins; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
chemical_list: D011951:Receptors, Complement; D017463:Receptors, Complement 3b