Effects of nitrendipine on vascular integrity.
Ongoing investigations with vasodilating drugs have established their antihypertensive efficacy. Nitrendipine, a new calcium channel blocker and vasodilator, not only decreases blood pressure but also has a tissue-protective effect that improves impaired renal function and prevents generalized vasculopathy in hypertensive animals. In addition, nitrendipine appears to preserve tissue integrity in both prophylaxis and therapy. These findings suggest that the development of vascular lesions and target organ damage associated with hypertension are not due merely to high intravascular pressure, but that some additional factors such as cellular calcium overload may be involved.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D006332:Cardiomegaly / Q000517:prevention & control; D002561:Cerebrovascular Disorders / Q000503:physiopathology; D005260:Female; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D009568:Nitrendipine / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D012965:Sodium Chloride / Q000494:pharmacology
D012965:Sodium Chloride; D009568:Nitrendipine