title: Mechanisms of pancreatic B-cell degeneration during the course of insulin-dependent diabetes mellitus.
abstract: This paper presents a review of different mechanisms possibly responsible for the degeneration of the pancreatic B-cell in insulin-dependent diabetes mellitus. The genetic dependence probably located in the HLA DR-locus of the sixth chromosome and its role in an autoimmune reaction against antigenically altered pancreatic B-cells is discussed. The actions of alloxan and streptozotocin in the induction of experimental diabetes, as models for postulated human B-cytotoxins, are described.
mesh_terms: D000496:Alloxan / Q000633:toxicity; D000818:Animals; D001327:Autoimmune Diseases / Q000150:complications; D002906:Chromosomes, Human, 6-12 and X; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D006680:HLA Antigens / Q000235:genetics; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D007515:Islets of Langerhans / Q000473:pathology* / Q000503:physiopathology; D051379:Mice; D013311:Streptozocin / Q000633:toxicity; D014777:Virus Diseases / Q000150:complications
chemical_list: D006680:HLA Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D013311:Streptozocin; D000496:Alloxan