title: Effect of protein-calorie malnutrition on drug metabolising enzymes in rat liver.
abstract: Drugs are chiefly metabolised in the liver usually in two phases, viz. oxidation and conjugation. The present study was undertaken to investigate the effect of protein-calorie malnutrition (PCM), rehabilitation and effect of phenobarbitone on the hepatic drug metabolising enzymes in weanling albino rats, fed on a semisynthetic diet containing 18% or 0.5% protein. The two representative enzymes of oxidation and conjugation employed were aminopyrine N-demethylase and bilirubin UDP-glucuronyl transferase, respectively. The study revealed that PCM severely impairs oxidative drug metabolising enzyme but less so in conjugation stage. On refeeding 18% protein diet, drug metabolising enzymes returned to normal within 2-3 weeks. Phenobarbitone administration increased the activities of drug metabolising enzymes.
mesh_terms: D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D004032:Diet; D005964:Glucosyltransferases / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009929:Organ Size; D010634:Phenobarbital / Q000494:pharmacology; D011502:Protein-Energy Malnutrition / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006899:Mixed Function Oxygenases; D000633:Aminopyrine N-Demethylase; D005964:Glucosyltransferases; C035814:bilirubin UDP-glucosyltransferase; D010634:Phenobarbital