Neonatal striatal grafts prevent lethal syndrome produced by bilateral intrastriatal injection of kainic acid.
It is reported that unilateral grafts of neonatal striatal tissue protect the recipient from the lethal aphagia and adipsia produced by bilateral intrastriatal injection of 10 nmol of kainic acid in rats. It is shown that neither adult striatum nor neonatal tissue from other sites have the same lifesaving effect and that the salutary effect of the graft is dependent upon graft survival. Grafts from a histoincompatible donor are apparently rejected, leading to the death of the recipient. Cyclosporine inhibits rejection thereby enabling recipient survival. It is postulated that the graft exerts a neurohumoral influence that protects the striatum from the toxic effect of kainate.
D000818:Animals; D000831:Animals, Newborn; D001480:Basal Ganglia Diseases / Q000139:chemically induced / Q000628:therapy; D003342:Corpus Striatum / Q000637:transplantation; D004195:Disease Models, Animal; D005260:Female; D006816:Huntington Disease / Q000209:etiology / Q000628:therapy; D007608:Kainic Acid; D051381:Rats; D011917:Rats, Inbred Lew
D007608:Kainic Acid