Suppression of delayed-type hypersensitivity to histocompatibility antigens by ultraviolet radiation.
Delayed-type hypersensitivity (DTH) reactions to allogeneic histocompatibility antigens in mice could be systemically suppressed by a single exposure to UV-B irradiation. The extent of suppression reached its maximum 4 days after irradiation, gradually waned thereafter, and disappeared at Day 21. Re-exposure of these mice to UV-B after waning reinduced the state of suppression. The suppression could be transferred to naive mice by means of splenic T lymphocytes. The suppressor T (Ts) cells suppressed the proliferative activity in the lymph nodes draining the site of immunization, but not the activity of already activated DTH-reactive T cells. Phenotypical analysis of these Ts cells revealed that two subpopulations of T cells are involved: one with the Lyt-1+, 2- phenotype, the other with the Lyt-1-, 2+ phenotype.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D005260:Female; D006649:Histocompatibility Antigens / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007108:Immune Tolerance / Q000528:radiation effects*; D007700:Kinetics; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014466:Ultraviolet Rays
D000954:Antigens, Surface; D006649:Histocompatibility Antigens