Comparative study of cefoperazone and spectinomycin for treatment of uncomplicated gonorrhea in men.
Beta-lactamase-negative Neisseria gonorrhoeae infections were treated with single-dose cefoperazone (0.5 or 1.0 g) or spectinomycin (2.0 g). Anogenital infections were cured in 36 (83%) of 43 volunteers given 0.5 g of cefoperazone, 61 of 61 volunteers given 1.0 g of cefoperazone, and 99 of 100 volunteers given spectinomycin. The cefoperazone geometric mean MIC for 242 isolates was 0.028 microgram/ml. Cefoperazone (1.0 g) and spectinomycin (2.0 g) are comparable for the therapy of anogenital gonorrhea in men.
D000293:Adolescent; D000328:Adult; D002438:Cefoperazone / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000150:complications / Q000628:therapy; D002692:Chlamydia trachomatis; D006069:Gonorrhea / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D011897:Random Allocation; D000198:Spectinomycin / Q000627:therapeutic use*
D002438:Cefoperazone; D000198:Spectinomycin