Double-blind study on antitissue immunoglobulin injections versus placebo in the treatment of acute lumbar pain with muscular spasms.
A double-blind study was carried out on antitissue immunoglobulins (Sérocytol Neuro-Vasculaire) administered by intradermal injections to 44 patients (24 women, 20 men; age range 36-76 years) suffering from acute lumbar pain accompanied by muscular spasms. In the treated group of 21 patients, excellent or good results were recorded in 14 cases (67%) and moderate results or no effect in 7 (33%). The mean number of injections necessary was 3.7 per patient. Injections were given every four days. In the placebo group of 20 patients (an addition 3 having dropped out), excellent or good results were obtained in 6 cases (30%) and moderate results or no effect in 14 (70%). The mean number of injections required was 4.6 per patient. The parameters considered included pain (night wakings, spontaneous pain and pain on pressure) and mobility (Schober's index, distance from fingertips to ground, extension, lateroflexion). The investigating physician's evaluation of the efficacy of antitissue immunoglobulins was similar to that of the patients. Tolerance of the product was excellent in all cases.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001416:Back Pain / Q000628:therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity / Q000628:therapy*; D010919:Placebos
D010919:Placebos