title: Fructose 2,6-bisphosphate and glucose 1,6-bisphosphate in avian and mammalian erythroid cells.
abstract: Chicken erythrocytes contain fructose 2,6-P2 at a concentration (0.6 nmol/10(9) cells) lower than that of glucose 1,6-P2 (5.4 nmol/10(9) cells) and similar to that of 2,3-bis phosphoglycerate (1.2 nmol/10(9) cells). In chick embryo erythrocytes the content of both bisphosphorylated hexoses is much lower. They begin to increase at hatching and reach chicken values in a few days. Fructose 2,6-P2 at microM concentration activates phosphofructokinase from chicken erythrocytes and releases the inhibition produced by ATP, 2,3-bisphosphoglycerate and inositol hexaphosphate. Glucose 1,6-P2 has similar effects but at much greater concentration. Rabbit reticulocytes contain fructose 2,6-P2 at a concentration (39 pmol/10(9) cells) much lower than that of glucose 1,6-P2 (74 nmol/10(9) cells).
mesh_terms: D019794:2,3-Diphosphoglycerate; D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D004163:Diphosphoglyceric Acids / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D005635:Fructosediphosphates / Q000097:blood*; D019298:Glucose-6-Phosphate / Q000031:analogs & derivatives*; D005958:Glucosephosphates / Q000097:blood*; D006598:Hexosediphosphates / Q000097:blood*; D008297:Male; D010732:Phosphofructokinase-1 / Q000097:blood; D011817:Rabbits; D012156:Reticulocytes / Q000378:metabolism
chemical_list: D004163:Diphosphoglyceric Acids; D005635:Fructosediphosphates; D005958:Glucosephosphates; D006598:Hexosediphosphates; D019794:2,3-Diphosphoglycerate; D019298:Glucose-6-Phosphate; C027652:fructose 2,6-diphosphate; C016473:glucose-1,6-bisphosphate; D010732:Phosphofructokinase-1