Antithrombotics in view of thrombosis models.
Two highly sensitive models of arterial and venous thrombosis forming with the test of endothelial stability a complementary system with a maximum stress on the role of vascular lesion were used to test a series of four antithrombotic drugs (heparin, acetylsalicylic acid, dipyridamole, sulfinpyrazone) and four drugs with other indications but with an antithrombotic activity in experiment (prenylamine, troxerutin, ketanserin and pizotifen). All drugs, except heparin, were given orally. Whereas heparin, aspirin and prenylamine had mixed effects on both arterial thrombosis (i.e. mostly on platelet functions) as well as on endothelial stability, ketanserin and pizotifen had a predominant effect on the former while dipyridamole, troxerutin and sulfinpyrazone influenced mostly the latter function.
D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D001158:Arteries / Q000503:physiopathology; D001241:Aspirin / Q000627:therapeutic use; D004176:Dipyridamole / Q000627:therapeutic use; D005260:Female; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives / Q000627:therapeutic use; D007650:Ketanserin; D010880:Piperidines / Q000627:therapeutic use; D010918:Pizotyline / Q000627:therapeutic use; D011299:Prenylamine / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D013442:Sulfinpyrazone / Q000627:therapeutic use; D013924:Thrombophlebitis / Q000188:drug therapy* / Q000503:physiopathology; D013927:Thrombosis / Q000188:drug therapy* / Q000503:physiopathology
D000925:Anticoagulants; D006896:Hydroxyethylrutoside; D010880:Piperidines; D010918:Pizotyline; D004176:Dipyridamole; C005865:troxerutin; D007650:Ketanserin; D011299:Prenylamine; D001241:Aspirin; D013442:Sulfinpyrazone