title: [Clinical experiences with atrial natriuretic factor].
abstract: Myocardial cells of mammals release a peptide with diuretic, natriuretic and vasodilating properties into the circulation. This peptide, called atrial natriuretic factor, is also involved in the regulation of plasma volume and, in addition, is instrumental in suppressing the activity of the renin-angiotensin-aldosterone system. The renal effects of the atrial natriuretic factor become less pronounced when systemic blood pressure is lowered. The auricular natriuretic factor seems to play an important role in cardiovascular regulation due to both its renal and extrarenal actions.
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects; D006333:Heart Failure / Q000097:blood; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007668:Kidney / Q000502:physiology; D008103:Liver Cirrhosis / Q000097:blood; D051381:Rats; D012084:Renin-Angiotensin System / Q000187:drug effects
chemical_list: D009320:Atrial Natriuretic Factor
vernacular_title: Expériences cliniques avec le facteur natriurétique auriculaire.