The peptide beta 43-47 which increases microvascular permeability is released by plasmin during cleavage of fragment Y of fibrinogen.
A synthetic pentapeptide corresponding to sequence 43-47 of human fibrinogen B beta chain elicited, in rabbits, antibodies that during immunoblotting recognized intact fibrinogen, fragments X and Y as well as the B beta chain. Since fragment Y is the last peptide product which reacts with anti-beta 43-47 antibodies, splitting of fragment Y into fragment D and fragment E must be accompanied by plasmin cleavage of the peptide bond beta Lys-47-Ala-48.
D000818:Animals; D000906:Antibodies; D000936:Antigen-Antibody Complex; D002199:Capillary Permeability; D005338:Fibrin Fibrinogen Degradation Products / Q000502:physiology*; D005341:Fibrinolysin / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D011817:Rabbits
D000906:Antibodies; D000936:Antigen-Antibody Complex; D005338:Fibrin Fibrinogen Degradation Products; C036129:fibrinogen fragment Y; C026893:fibrinogen peptide 6A; D005341:Fibrinolysin