title: Role of drugs for systemic hypertension and their effect on the heart.
abstract: The effects of hypertension on the heart include the development of left ventricular hypertrophy, impairment of left ventricular function leading to heart failure and accelerated coronary atherosclerosis leading to ischemic heart disease. The precise role of hypertension in precipitating these cardiac events is poorly understood, and the effect of antihypertensive drugs in preventing or reversing these abnormalities is surprisingly unclear. Current understanding of the pathophysiology and therapeutic responses of these cardiac manifestations of hypertension will be examined.
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006332:Cardiomegaly / Q000209:etiology; D003327:Coronary Disease / Q000209:etiology; D006321:Heart / Q000187:drug effects*; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*
chemical_list: D000959:Antihypertensive Agents