The streptozotocin-prostaglandin interaction in Golgi apparatus of rat liver.
16,16'-Dimethylprostaglandin E2 was administered to rats in three doses: 30 min prior and 24 h and 48 h after a single intraperitoneal injection of streptozotocin. The Golgi membrane fraction was analyzed 6 days after streptozotocin injection. It has been found that prostaglandin restores the Golgi membrane fraction and the activity of UDP-Gal----GlcNAc transferase, both significantly decreased upon treatment with streptozotocin alone. Morphology of the liver Golgi apparatus studied by the electron microscopy was similar to that of control from untreated rats although streptozotocin alone significantly decreased the size of this organelle.
D015064:16,16-Dimethylprostaglandin E2 / Q000494:pharmacology*; D000818:Animals; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D009237:N-Acetyllactosamine Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin / Q000037:antagonists & inhibitors* / Q000633:toxicity
D011459:Prostaglandins E, Synthetic; D013311:Streptozocin; D009237:N-Acetyllactosamine Synthase; D015064:16,16-Dimethylprostaglandin E2