4;11 translocation-associated acute leukemia: a comprehensive analysis.
A girl with common acute lymphoblastic leukemia associated with t(4;11)(q21;q23) is presented. The physical examination revealed hepatosplenomegaly, and the hematologic analysis showed a high count of white cells. Chemotherapy induced a complete remission (CR), and the patient is still in CR (8 months). At the present time, 43 cases (including ours) of acute leukemia with t(4;11) have been published. This disease more often affects children and women than adult men and is characterized by a high blood white cell count and a short survival. The t(4;11)-associated acute leukemia is a heterogeneous group, including acute undifferentiated leukemia, acute undifferentiated lymphoblastic leukemia, and "common" acute lymphoblastic leukemia.
D000293:Adolescent; D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D002905:Chromosomes, Human, 4-5; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D007958:Leukocyte Count; D008297:Male; D015260:Neprilysin; D014178:Translocation, Genetic
D000951:Antigens, Neoplasm; D015260:Neprilysin