title: [Acanthosis nigricans maligna and Leser-Trélat sign in double malignancy of the breast and stomach].
abstract: A female patient with primary cancer of the breast and the stomach developed acanthosis nigricans maligna and Leser-Trélat's sign. Acanthosis nigricans maligna is a well-known cutaneous marker of internal malignancy. It may be intensified by radiotherapy. A variant is called florid cutaneous papillomatosis. Leser-Trélat's sign is a rare cutaneous marker of internal neoplasms. According to the literature, we present 46 patients showing Leser-Trélat's sign. Neither Leser nor Trélat described this sign.
mesh_terms: D000052:Acanthosis Nigricans / Q000473:pathology*; D000230:Adenocarcinoma / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D012628:Dermatitis, Seborrheic / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000473:pathology*; D011832:Radiation Injuries / Q000473:pathology; D012867:Skin / Q000473:pathology / Q000528:radiation effects; D013274:Stomach Neoplasms / Q000473:pathology*
vernacular_title: Acanthosis nigricans maligna und Leser-Trélat-Zeichen bei Doppelmalignom von Mamma und Magen.