Comparison between atracurium and alcuronium for muscle relaxation during laparoscopy.
Atracurium 0.3 mg/kg was compared with alcuronium 0.25 mg/kg as the sole muscle relaxant for tracheal intubation and abdominal relaxation for gynaecological laparoscopy in 46 patients during nitrous oxide, oxygen and halothane anaesthesia. Speed of onset, intubation conditions, effect on blood pressure and pulse rate, and ease of reversal were compared. Alcuronium had a significantly faster onset of action than atracurium; intubation conditions were adequate and abdominal relaxation was satisfactory for both drugs. The effect of atracurium was readily reversible within 10 minutes; in contrast alcuronium was significantly more resistant and mean recovery time was 28.03 minutes. Although alcuronium provided good muscle relaxation, it is not suitable for short procedures because of difficulty in reversing its action. Atracurium allowed earlier and more complete reversal of neuromuscular block.
D000328:Adult; D000443:Alcuronium / Q000494:pharmacology*; D001279:Atracurium; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D007546:Isoquinolines / Q000494:pharmacology*; D010535:Laparoscopy; D009119:Muscle Contraction / Q000187:drug effects*; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D009126:Muscle Relaxation / Q000187:drug effects*; D009407:Nerve Block; D011897:Random Allocation; D014117:Toxiferine / Q000031:analogs & derivatives*
D007546:Isoquinolines; D009125:Muscle Relaxants, Central; D001279:Atracurium; D014117:Toxiferine; D000443:Alcuronium