YIGSR, a synthetic laminin pentapeptide, inhibits experimental metastasis formation.
The invasion of tumor cells through basement membranes is a critical step in the formation of metastases. The binding of the malignant cells to laminin in the basement membranes allows their attachment and activates their invasiveness. Recently a synthetic nonapeptide from the B1 chain sequence of laminin was identified as a major site for cell binding. A pentapeptide within the nonapeptide sequence was found to reduce the formation of lung colonies in mice injected with melanoma cells and also to inhibit the invasiveness of the cells in vitro.
D000818:Animals; D001485:Basement Membrane / Q000503:physiopathology; D001665:Binding Sites; D002448:Cell Adhesion / Q000187:drug effects*; D007797:Laminin; D008175:Lung Neoplasms / Q000556:secondary; D008546:Melanoma, Experimental / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000187:drug effects*; D017474:Receptors, Laminin; D013329:Structure-Activity Relationship
D007797:Laminin; D009842:Oligopeptides; D011971:Receptors, Immunologic; D017474:Receptors, Laminin