Determinants of salvage of jeopardized myocardium after coronary thrombolysis.
Coronary thrombolysis is an attractive approach for salvaging jeopardized, ischemic myocardium. The advent of second- and third-generation clot-selective thrombolytic agents will make this approach safer and more widely applicable in the future. However, residual stenoses and reocclusion are common after the thrombolytic therapy. In addition to thrombolysis, future management of coronary thrombosis may include adjunctive pharmacologic therapy such as calcium-channel antagonists, beta-blockers, or oxygen free radical scavengers, and/or mechanical interventions such as balloon or laser angioplasty, or bypass surgery.
D000800:Angioplasty, Balloon; D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology / Q000628:therapy; D009206:Myocardium / Q000378:metabolism; D010477:Perfusion; D013482:Superoxide Dismutase / Q000627:therapeutic use; D013565:Sympatholytics / Q000627:therapeutic use; D013997:Time Factors
D002121:Calcium Channel Blockers; D005343:Fibrinolytic Agents; D013565:Sympatholytics; D013482:Superoxide Dismutase