Fentanyl and the beta-endorphin, ACTH and glucoregulatory hormonal response to surgery.
The effect of the supplementation of nitrous oxide-oxygen anaesthesia with either fentanyl 15 micrograms kg-1 or 0.5% halothane on the beta-endorphin, ACTH, glucoregulatory hormonal and metabolic response to pelvic surgery was investigated. Fentanyl inhibited the increases in circulating beta-endorphin, ACTH, growth hormone, cortisol and glucose concentrations found in the patients receiving halothane. Changes in circulating beta-endorphin concentrations during surgery probably reflect alterations in pituitary secretion and appear to have no major metabolic effects. The suppression of pituitary secretion persisted for at least 4 h after the start of surgery.
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D004723:Endorphins / Q000097:blood*; D005260:Female; D005283:Fentanyl / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D010187:Pancreatic Hormones / Q000097:blood; D010908:Pituitary Hormones, Anterior / Q000097:blood; D013514:Surgical Procedures, Operative; D001615:beta-Endorphin
D001786:Blood Glucose; D004723:Endorphins; D006728:Hormones; D007773:Lactates; D010187:Pancreatic Hormones; D010908:Pituitary Hormones, Anterior; D019344:Lactic Acid; D001615:beta-Endorphin; D005283:Fentanyl; D006854:Hydrocortisone