Effect of chronic ingestion of iodide during pregnancy and lactation on rat pup brain enzymes.
The developmental pattern of several key enzymes in brain of pups born to mothers receiving high levels of iodide (1.1 mg daily intake) during pregnancy and lactation were followed up to the weaning period. We found that in the initial states of postnatal development, glutamic dehydrogenase increased above control levels, whereas succinic dehydrogenase decreased. At late stages, we observed differences in phosphofructokinase and malic enzyme activities which were all increased at 30 days. There was no change in hexokinase. Animal weight did not vary with respect to controls and we only obtained discrete increases (not statistically different) in serum thyroxine values, which led us to assume that the enzymatic modifications might be a consequence of either a very mild hormonal alteration or to the direct effect of iodide.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D005260:Female; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D006128:Growth / Q000187:drug effects; D008291:Malate Dehydrogenase / Q000378:metabolism; D010732:Phosphofructokinase-1 / Q000378:metabolism; D011193:Potassium Iodide / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013974:Thyroxine / Q000097:blood
D011193:Potassium Iodide; D008291:Malate Dehydrogenase; D013385:Succinate Dehydrogenase; D005969:Glutamate Dehydrogenase; D010732:Phosphofructokinase-1; D013974:Thyroxine