Generation of B suppressor cells by phytohaemagglutinin.
Activation by phytohaemagglutinin-P (PHA-P) of B cells from peripheral blood of healthy subjects generated B suppressor cells which inhibited allogeneic mixed lymphocyte reactions (MLR) and PHA-induced DNA synthesis. Their action was direct, that is, not mediated through the induction of T suppressor cells. The finding that B cells can be induced by PHA to become highly effective suppressor cells may have important clinical and experimental implications.
D001402:B-Lymphocytes / Q000276:immunology*; D004247:DNA / Q000096:biosynthesis; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007108:Immune Tolerance; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D010835:Phytohemagglutinins / Q000494:pharmacology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D010835:Phytohemagglutinins; C028784:phytohemagglutinin-P; D004247:DNA