title: L-carnitine effect on halothane-treated mitochondria.
abstract: Addition of halothane to the incubation medium is shown to lower respiratory control and transmembrane potential and to increase ATPase activity in isolated rat liver mitochondria. Evidence is presented that L-carnitine is able to substantially decrease the negative effects of halothane on the energy-linked processes of mitochondria. The effects of halothane and the protective action of L-carnitine are discussed in the light of a possible involvement of long-chain acyl CoA in the unpairing of mitochondrial energy-linked functions.
mesh_terms: D000214:Acyl Coenzyme A / Q000494:pharmacology; D000251:Adenosine Triphosphatases / Q000032:analysis; D000818:Animals; D002331:Carnitine / Q000494:pharmacology*; D006221:Halothane / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000214:Acyl Coenzyme A; D000251:Adenosine Triphosphatases; D002331:Carnitine; D006221:Halothane