Human T cell gamma chain joining regions and T cell development.
We have cloned and sequenced two homologous J regions of the T cell gamma gene and localized one 5' of each constant region. They have been numbered J gamma 1.1 and J gamma 2.1; other J regions have been renamed in a similar manner. Southern blot analysis suggests that there is comparatively more rearrangement to these J regions in thymocytes than peripheral blood T cells. We propose that either there is gamma-chain gene rearrangement first to J gamma 1.1 or 2.1 and then to J gamma 1.3 or 2.3, or there is selected cell death of thymic T cells bearing a J gamma 1.1 or 2.1 rearrangement.
D000328:Adult; D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation; D005796:Genes; D005802:Genes, MHC Class II; D006801:Humans; D051379:Mice / Q000235:genetics; D008954:Models, Biological; D010446:Peptide Fragments / Q000235:genetics*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D016692:Receptors, Antigen, T-Cell, gamma-delta; D011995:Recombination, Genetic; D013601:T-Lymphocytes / Q000032:analysis / Q000166:cytology*; D013950:Thymus Gland / Q000032:analysis
D010446:Peptide Fragments; D011948:Receptors, Antigen, T-Cell; D016692:Receptors, Antigen, T-Cell, gamma-delta