T suppressor afferent cells which regulate contact sensitivity to picryl chloride act across genetic barrier.
This paper investigates the requirement for genetic restriction in the action of T suppressor afferent cells (Ts-aff) which regulate the induction phase of contact sensitivity to picryl chloride. The results here reported show that Ts-aff which inhibit both the induction of contact sensitivity and DNA synthesis in the draining lymph nodes of sensitized mice, act across both H-2 and Igh genetic barrier and constitute new evidence which discriminates between two T suppressor cell populations in contact sensitivity.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D003877:Dermatitis, Contact / Q000235:genetics / Q000276:immunology*; D006183:H-2 Antigens / Q000235:genetics* / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008815:Mice, Inbred Strains / Q000276:immunology; D010853:Picryl Chloride / Q000276:immunology / Q000494:pharmacology*; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000187:drug effects / Q000276:immunology*
D006183:H-2 Antigens; D004247:DNA; D010853:Picryl Chloride