Decreased monocyte production of interleukin-1 and impaired lymphocyte proliferation in atopic dermatitis.
We studied lymphocyte proliferation and subsets in ten atopic dermatitis (AD) patients and ten healthy controls. In addition, monocyte production of interleukin 1 (IL-1) was investigated. Mean numbers of total T cells, T-cells subsets, and B cells did not significantly differ between AD patients and controls even though the patients had slightly decreased amounts of suppressor T lymphocytes. Proliferative responses of AD patients to purified protein derivative of tuberculin (PPD), concanavalin A (ConA), or allogeneic cells did not significantly differ from those of healthy controls at optimal stimulant concentrations. In contrast, at suboptimal concentrations, AD patients showed a diminished response to all of these stimulants. Monocytes from AD patients elaborated clearly less IL-1 than those from healthy controls.
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D003876:Dermatitis, Atopic / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007375:Interleukin-1 / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D009000:Monocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D007375:Interleukin-1; D007073:Immunoglobulin E