title: Susceptibility of cartilage to damage by immunological inflammation.
abstract: Injection of ovalbumin into subcutaneous air pouches prepared on the backs of rats previously sensitised to the antigen resulted in the induction of a small and transient accumulation of inflammatory fluid with a predominantly polymorph cell infiltrate. Challenge of pouches of appropriately sensitised rats with Bordetella pertussis vaccine, on the other hand, resulted in a larger and more prolonged accumulation of fluid and cells with a predominantly mononuclear presence. When intact homologous femoral head cartilage was implanted in these inflamed pouches proteoglycan loss was found to be not different from similar implants in non-inflamed pouches. Coating the cartilage with human heat-aggregated immunoglobulin G prior to implantation in air pouches was also found to be without effect on subsequent proteoglycan loss.
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000503:physiopathology*; D001183:Arthus Reaction; D002358:Cartilage, Articular / Q000276:immunology*; D005260:Female; D008297:Male; D009504:Neutrophils / Q000166:cytology; D010047:Ovalbumin / Q000494:pharmacology; D010567:Pertussis Vaccine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010567:Pertussis Vaccine; D010047:Ovalbumin