The beta-endorphin-induced secretion of growth hormone but not of prolactin is inhibited by an endogenous opioid antagonist.
The naturally occurring peptide human beta-endorphin-(1-27) (h beta-EP-(1-27) has been shown to antagonize beta-endorphin (h beta-EP)-induced analgesia. We have evaluated the effects of the fragment on h beta-EP-induced growth hormone (GH) and prolactin (PRL) release. It inhibited beta-EP-induced GH release in a dose-related way but left beta-EP-induced PRL stimulation unchanged.
D000818:Animals; D004723:Endorphins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013006:Growth Hormone / Q000378:metabolism*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin
D004723:Endorphins; D010446:Peptide Fragments; D001615:beta-Endorphin; C035581:beta-endorphin (1-27); D011388:Prolactin; D013006:Growth Hormone