title: [Dependence of the specific activity of antitetanus immunoglobulin on the degree of its fragmentation].
abstract: Antitetanus immunoglobulin preparations with the increasing content of Fab-fragments (15, 30, 53%) have been obtained under specific experimental conditions. Tests for specific activity have revealed an insignificant decrease (13%) in this activity in the preparation containing 15% of Fab-fragments and its sharp drop in the preparations containing 30-50% of Fab-fragments. The specific activity of antitetanus immunoglobulin has been found to be related to the degree of its fragmentation.
mesh_terms: D000818:Animals; D000918:Antibody Specificity / Q000187:drug effects; D002855:Chromatography, Thin Layer; D003017:Clostridium tetani / Q000276:immunology*; D005341:Fibrinolysin / Q000494:pharmacology; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000032:analysis / Q000276:immunology; D007128:Immunoglobulin Fragments / Q000032:analysis / Q000276:immunology*; D051379:Mice; D013329:Structure-Activity Relationship; D013742:Tetanus / Q000517:prevention & control; D014358:Trypsin Inhibitor, Bowman-Birk Soybean / Q000494:pharmacology
chemical_list: D007140:Immunoglobulin Fab Fragments; D007128:Immunoglobulin Fragments; D014358:Trypsin Inhibitor, Bowman-Birk Soybean; D005341:Fibrinolysin
vernacular_title: Izuchenie zavisimosti spetsificheskoĭ aktivnosti protivostolbniachnogo immunoglobulina ot stepeni fragmentatsii.