The relative roles of genetic and environmental factors in the regulation of erythrocyte C3b receptor (ECR1) numbers in normal individuals.
Erythrocyte C3b receptors (ECR1) have been measured in 122 pairs of twins (60 monozygotic, 62 dizygotic) using an [125I]-labelled monoclonal antibody (E11). The range of ECR1 numbers was wide, 99-4179 sites/cell, with a log-normal distribution around a geometric mean of 837 sites/cell. The intra-pair variance in dizygotic twins was no greater than that in monozygotic twins. These data indicate that ECR1 numerical expression is governed by environmental rather than genetic factors.
D000293:Adolescent; D000328:Adult; D000368:Aged; D004777:Environment; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011951:Receptors, Complement / Q000032:analysis / Q000235:genetics*; D017463:Receptors, Complement 3b; D012016:Reference Values; D014427:Twins; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D011951:Receptors, Complement; D017463:Receptors, Complement 3b