The effects of reverse sequential anti-androgen therapy (cyproterone acetate and ethinyl estradiol) on hematological parameters.
Hematological parameters were studied in female patients receiving reverse-sequential anti-androgen therapy for hirsutism and acne. A significant fall in hemoglobin, total red cell count and packed cell volume occurred after 3-month treatment in 30 patients during the 10-day cyproterone acetate and ethinyl estradiol phase; this change was sustained in 14 patients studied to 12 months. A fall in hemoglobin and packed cell volume alone occurred after 3 months in 31 patients in the ethinyl estradiol phase. Reverse-sequential therapy may influence hemopoiesis by its anti-androgenic action on erythropoiesis, although we found no relationship between changes in hematological parameters and total testosterone levels.
D000152:Acne Vulgaris / Q000097:blood* / Q000188:drug therapy; D000726:Androgen Antagonists / Q000627:therapeutic use*; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017373:Cyproterone Acetate; D004359:Drug Therapy, Combination; D004906:Erythrocyte Count; D004997:Ethinyl Estradiol / Q000627:therapeutic use*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006628:Hirsutism / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D011446:Prospective Studies; D013739:Testosterone / Q000097:blood
D000726:Androgen Antagonists; D006454:Hemoglobins; D013739:Testosterone; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; D003534:Cyproterone