Acute haemodynamic and hormonal effects of oral doxazosin in normal subjects.
Haemodynamic and hormonal effects of doxazosin, a long-acting alpha 1-adrenoceptor antagonist (2 mg) were compared with placebo in six normal men. Doxazosin at 2 mg produced lower supine systolic blood pressure and plasma cortisol concentration than control at 4 h only, but these changes were not sustained. Both supine and standing pulse rate were increased by active drug after 6 h. In this acute study doxazosin did not affect plasma renin or aldosterone concentrations.
D000284:Administration, Oral; D000328:Adult; D000450:Aldosterone / Q000097:blood; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D017292:Doxazosin; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D011224:Prazosin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D012083:Renin / Q000097:blood
D000959:Antihypertensive Agents; D000450:Aldosterone; D012083:Renin; D017292:Doxazosin; D006854:Hydrocortisone; D011224:Prazosin