Steroid receptors and response to hormonal and cytotoxic agents in vitro in two cases of androblastoma.
Cytosol steroid receptor contents of 2 tubular androblastomas were determined and that was correlated with the response to hormonal (tamoxifen and medroxyprogesterone acetate) and cytotoxic agents (chlorambucil, vincristine, cisplatin and etoposide) using a new in vitro method based on ATP measurement of cultured cells. Both androblastomas showed low receptor contents and no response to medroxyprogesterone acetate, tamoxifen or their combination was found. Furthermore, there was no response to chlorambucil or vincristine or their combination as well as to the combination of tamoxifen and vincristine in one tumor. The other tumor, however, showed good in vitro response to cisplatin and the combination of cisplatin and etoposide.
D000255:Adenosine Triphosphate / Q000032:analysis; D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004338:Drug Combinations; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017258:Medroxyprogesterone Acetate; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D011987:Receptors, Steroid / Q000187:drug effects*; D012707:Sertoli Cell Tumor / Q000188:drug therapy*; D013629:Tamoxifen / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004338:Drug Combinations; D011987:Receptors, Steroid; D013629:Tamoxifen; D000255:Adenosine Triphosphate; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone