Selective antagonism of S2-serotonergic receptors relieves but does not prevent cold induced vasoconstriction in primary Raynaud's phenomenon.
In a double blind placebo crossover study, intravenous ketanserin, an antagonist of S2-serotonergic receptors, did not improve plethysmographically monitored digital blood flow during controlled cold challenge in 4 women with carefully defined primary Raynaud's phenomenon. However, ketanserin, if administered at the time of cold induced vasoconstriction, caused prompt vasodilation. These results suggest that serotonin is a contributory element in the maintenance of cold induced vasospasm but that other factors, presumedly adrenergic, initiate the vasoconstrictive response.
D000328:Adult; D003080:Cold Temperature; D005260:Female; D006801:Humans; D007650:Ketanserin; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use*; D011928:Raynaud Disease / Q000188:drug therapy* / Q000503:physiopathology; D011941:Receptors, Adrenergic / Q000502:physiology; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects
D010880:Piperidines; D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin; D007650:Ketanserin