Measurement of the amino acid metabolite of phencyclidine by selected ion monitoring.
A technique is described for the extraction and quantitation of the pentanoic acid metabolite of phencyclidine by gas chromatography/mass spectrometry. This compound was measured in urine samples from asymptomatic pregnant patients who used phencyclidine (PCP) and their neonates. The technique is sensitive to 25 ng ml-1 urine and standard curves were linear at 25-2000 ng ml-1. Levels in samples from asymptomatic patients were 27-1388 ng ml-1. Results suggest that the pentanoic acid metabolite could be considered as a screening marker for occasional PCP use.
D000596:Amino Acids / Q000652:urine*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007231:Infant, Newborn; D010622:Phencyclidine / Q000378:metabolism / Q000652:urine*; D011247:Pregnancy
D000596:Amino Acids; D010622:Phencyclidine