[Results of a trial of a plague monoclonal antibody erythrocyte diagnostic agent].
Plague antibody monoclonal erythrocyte diagnosticum was studied in serological tests simultaneously with commercial plague antibody erythrocyte diagnosticum prepared on the basis of hyperimmune horse serum and with commercial plague antigenic erythrocyte diagnosticum. In this investigation the suspensions of numerous strains of Yersinia pestis, other closely related and heterologous organisms, experimentally infected wild and laboratory animals, as well as samples of materials obtained from small rodents caught in several natural foci of plague, were studied. The monoclonal diagnosticum was, practically, not inferior to the similar commercial preparation with respect to the frequency of positive results and the activity of the materials under study in serological tests, but showed greater specificity, as it reacted strictly with Y. pestis capsular antigen.
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial / Q000276:immunology; D004353:Drug Evaluation, Preclinical / Q000662:veterinary; D004912:Erythrocytes / Q000276:immunology*; D005849:Gerbillinae; D006168:Guinea Pigs; D007623:Kazakhstan; D051379:Mice; D008807:Mice, Inbred BALB C; D010930:Plague / Q000175:diagnosis* / Q000662:veterinary; D012589:Sciuridae; D015010:Yersinia pestis / Q000276:immunology*
D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial
Rezul'taty ispytaniia chumnogo antitel'nogo monoklonal'nogo éritrotsitarnogo diagnostikuma.