Cyclosporin A enhances streptozocin-induced diabetes in CD-1 mice.
Cyclosporin A (CYA), when administered to CD-1 mice treated with a subdiabetogenic dose of Streptozocin (STZ), exacerbated the STZ-induced insulitis and elevated the plasma glucose levels, parallel to a reduction of the insulin content of the pancreas. The possible mechanisms of CYA-mediated aggravation of STZ-induced diabetes are discussed.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003524:Cyclosporins / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D013311:Streptozocin
D001786:Blood Glucose; D003524:Cyclosporins; D007328:Insulin; D013311:Streptozocin