title: [Inhibitory effect of various hydrazine derivatives on the activity of L-phenylalanine ammonia-lyase from Rhodotorula glutinis].
abstract: The inhibitory activities of hydrazinoacetic acid (HAA), 2-hydrazinoethanol (HE) and ethyl hydrazino-acetate (EHA) are characterized and compared with those of L-or D-alpha-hydrazino-beta-phenylpropionic acid (L-or D-HPPA), 2-phenylethylhydrazine (PEH), hydrazine (H), alpha, beta-dihydrocinnamic acid (DHCA) and D-phenylalanine (D-Phe). Inhibitors can be arranged in order of increasing activity: HE less than EHA less than H less than D-Phe less than HAA less than D-HPPA less than DHCA less than PEH less than L-HPPA. Relations between activity and structure of inhibitors are discussed.
mesh_terms: D000642:Ammonia-Lyases / Q000037:antagonists & inhibitors*; D006834:Hydrazines / Q000494:pharmacology*; D007700:Kinetics; D003904:Mitosporic Fungi / Q000201:enzymology*; D010650:Phenylalanine Ammonia-Lyase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012248:Rhodotorula / Q000201:enzymology*
chemical_list: D006834:Hydrazines; D000642:Ammonia-Lyases; D010650:Phenylalanine Ammonia-Lyase
vernacular_title: Effet inhibiteur de divers dérivés de l'hydrazine sur l'activité de la L-phénylalanine ammonialyase de Rhodotorula glutinis.