title: [Studies of local treatment of psoriasis with a bifonazole-urea combination].
abstract: In a biometrically controlled study on psoriatic patients, we investigated the efficacy and tolerability of bifonazole 1% plus urea 20% cream. In each of our ten patients, two lesions were treated over a period of 29 to 40 days (34 days on the average). Therapeutic results were not satisfying with lesions on extremities in comparison to those on head and body. On head and trunk, the size of the lesions amounted to 11.8 and 10.3 cm2, resp., before treatment, 2.8 and 4.3 cm2, resp., after therapy. On the extremities, we only noticed a reduction in size from 15.8 cm2 before to 13.8 cm2 after treatment. In total, the therapy was considered successful in 14 of the 20 lesions. Especially those four patients who predominantly showed lesions of the sebopsoriatic type were well-improved. Thus this therapy is particularly recommended in case of sebopsoriasis.
mesh_terms: D000287:Administration, Topical; D012628:Dermatitis, Seborrheic / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D014508:Urea / Q000008:administration & dosage*
chemical_list: D007093:Imidazoles; D014508:Urea; C036596:bifonazole
vernacular_title: Lokale Behandlungsstudien der Psoriasis mit einer Bifonazol-Harnstoff-Kombination.