title: Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in Usher's syndrome.
abstract: Docosahexaenoate and arachidonate were found to be significantly decreased in plasma phospholipids from Usher's syndrome patients. The fatty acid content of plasma triacylglycerols was not changed in these patients. Usher's syndrome, an autosomal recessive disorder, involves an inherited visual cell degeneration. Photoreceptor membranes are richly endowed with docosahexaenoate and arachidonate, and a metabolic defect affecting these polyunsaturated fatty acids may occur. Moreover, blindness may be due, at least partially, to an alteration in the unsaturated phospholipids of photoreceptor membranes.
mesh_terms: D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood; D004281:Docosahexaenoic Acids; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D006801:Humans; D010743:Phospholipids / Q000097:blood*; D010786:Photoreceptor Cells / Q000378:metabolism; D012174:Retinitis Pigmentosa / Q000097:blood*; D013577:Syndrome; D014280:Triglycerides / Q000097:blood
chemical_list: D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D010743:Phospholipids; D014280:Triglycerides; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid