[Influence of antianginal drugs on Lypressin induced T-wave enhancement in the electrocardiogram of the rat].
Lypressin enhances the T-wave in the ECG of the anesthetized Sprague-Dawley rat and this has been used in screening for antianginal activity. After oral administration the durations of action of the organic nitrates, glyceryl trinitrate, isosorbide dinitrate, glyceryl 1,2-dinitrate, glyceryl 1,3-dinitrate and of SIN-1 (3-morpholinosydnonimine), molsidomine and nicorandil were shorter than those of verapamil and nifedipine. The sequence of the durations of action of the substances examined was the same in the rat as in man.
D000284:Administration, Oral; D000787:Angina Pectoris / Q000188:drug therapy; D000818:Animals; D003329:Coronary Vasospasm / Q000139:chemically induced / Q000188:drug therapy*; D004562:Electrocardiography; D000860:Hypoxia / Q000188:drug therapy; D007548:Isosorbide Dinitrate / Q000008:administration & dosage; D008236:Lypressin / Q000494:pharmacology*; D008297:Male; D008981:Molsidomine / Q000008:administration & dosage / Q000031:analogs & derivatives; D009536:Niacinamide / Q000008:administration & dosage / Q000031:analogs & derivatives; D020108:Nicorandil; D009543:Nifedipine / Q000008:administration & dosage; D005996:Nitroglycerin / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000008:administration & dosage
D009536:Niacinamide; D020108:Nicorandil; D008236:Lypressin; C002385:linsidomine; D014700:Verapamil; D008981:Molsidomine; D005996:Nitroglycerin; D009543:Nifedipine; D007548:Isosorbide Dinitrate
Einfluss antianginöser Substanzen auf die durch Lypressin induzierte T-Wellenerhöhung im EKG der Ratte.