title: [Lipoid nephrosis of toxic origin. 2 cases].
abstract: Classically, the histological lesion observed in a drug-or heavy metal-induced nephrotic syndrome is membranous glomerulonephritis. We report two cases of "toxic" nephrotic syndrome with unusual histological features. One was secondary to mercury intoxication and the other, to D-penicillamine in a patient with rheumatoid arthritis. In both cases, renal biopsy revealed minimal glomerular changes. The proteinuria rapidly disappeared after exposure to the toxic agent was discontinued. Genetic factors and a disregulation of the immune system with lymphokine production may be responsible for these renal changes. This study demonstrates that renal biopsy is necessary in this clinical setting.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008630:Mercury Poisoning / Q000175:diagnosis*; D009402:Nephrosis, Lipoid / Q000139:chemically induced* / Q000175:diagnosis; D009784:Occupational Diseases / Q000175:diagnosis*; D010396:Penicillamine / Q000009:adverse effects*
chemical_list: D010396:Penicillamine
vernacular_title: Néphrose lipoïdique d'origine "toxique". Deux cas.