[Inhibition of the repair of neutron-induced DNA single-strand breaks in experimental tumor cells].
Nicotinamide and arabinoside cytosine mixed with hydroxyurea were shown to influence the relative amount of double-stranded DNA in Ehrlich ascites tumor cells in vitro subjected to single irradiation (10-30-52 Gy) and in Guerin's carcinoma in rat lungs exposed to fractionated 6 MeV neutron-radiation (1.25 Gy X 4). The DMF values for Ehrlich ascites tumor were a function of a dose range and the duration of the drugs' effect. Guerin's carcinoma DNA was found to be affected more readily when treated with radiation and drugs than when exposed to neutron radiation alone.
D000818:Animals; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects*; D004273:DNA, Neoplasm / Q000187:drug effects / Q000528:radiation effects*; D004277:DNA, Single-Stranded / Q000187:drug effects / Q000528:radiation effects*; D004359:Drug Therapy, Combination; D006918:Hydroxyurea / Q000008:administration & dosage; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000532:radiotherapy*; D009502:Neutrons; D009536:Niacinamide / Q000008:administration & dosage; D051381:Rats
D004273:DNA, Neoplasm; D004277:DNA, Single-Stranded; D003561:Cytarabine; D009536:Niacinamide; D006918:Hydroxyurea
Ugnetenie protsessov reparatsii indutsirovannykh neĭtronami odnonitevykh razryvov DNK v kletkakh éksperimental'nykh opukholeĭ.