[Demonstration of new class I antigens in man].
The hypothesis of new class I antigens has been postulated in man, and several antigen systems have been proposed: HT (Gazit), TC (TCA, TCB) (Van Leeuwen). The present study describes a new class I antigenic marker system, expressed selectively on PHA-activated T lymphocytes and on lymphoblastoid B cell lines. These markers correlated at the cellular activation stage, have been called: human activation or HA markers. 7% of the sera from multiparous women present anti-HA antibodies. The definition of class I molecule (dimer 41K - 12K) has been established by a structural analysis of the molecule; the responsible gene, located on the 6th chromosome could be close to the HLA-A gene. The equivalence with the mouse Qa markers is postulated, but remains to be totally demonstrated.
D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D015234:HLA-A Antigens; D006801:Humans; D007163:Immunosorbent Techniques; D007518:Isoantibodies / Q000032:analysis; D007945:Leukemia, Lymphoid / Q000276:immunology; D046911:Macromolecular Substances; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D006680:HLA Antigens; D015234:HLA-A Antigens; D007518:Isoantibodies; D046911:Macromolecular Substances; D013755:Tetradecanoylphorbol Acetate
Mise en évidence de nouveaux antigènes de classe I chez l'homme.