Effect of tryptamine on the behavior of mice.
The effects of tryptamine (TRM) on behavior were investigated in mice. TRM at a dose of 50 mg/kg i.p. induced an inhibition of locomotor activity and, at doses ranging from 150 to 300 mg/kg, induced peculiar behaviors such as head twitch, head weaving, forepaw treading, hindlimb abduction and Straub tail. These behavioral effects were continuous, although TRM rapidly disappeared from the brain. Methysergide, a 5-hydroxytryptamine (5-HT) receptor antagonist, completely abolished TRM-induced excitatory behaviors and p-chlorophenylalanine, a 5-HT depleter, significantly inhibited the behaviors. Our results show that TRM induced both the depression and excitation in the behavior of mice depending on the dosage and TRM-induced excitatory behaviors may be attributed to both its direct stimulation of 5-HT receptors and facilitation of 5-HT release.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010293:Pargyline / Q000494:pharmacology; D013997:Time Factors; D014363:Tryptamines / Q000378:metabolism / Q000494:pharmacology*
D014363:Tryptamines; C030820:tryptamine; D010293:Pargyline; D010134:Fenclonine; D008784:Methysergide