[Th role of human intestinal flora on the metabolic activation of pyrolysis products].
The role of the intestinal flora on the metabolic activation of dipyrido 1,2-a:3',2'-d imidazole compounds was investigated with the Salmonella typhimurium test system, using strain TA98. The metabolic activation mixture was obtained from cell-free extracts from E. coli, B. fragilis and Cl. perfringens. Whereas these extracts were able to activate 2-AA (used as control), the 2 and 3 amino derivatives of dipyrido [1,2-a:3',2'-d] imidazole were not revealed as mutagenic.
D000588:Amines / Q000378:metabolism*; D000818:Animals; D002273:Carcinogens / Q000378:metabolism*; D005516:Food Microbiology; D006801:Humans; D007093:Imidazoles / Q000378:metabolism*; D007422:Intestines / Q000382:microbiology*; D009153:Mutagens / Q000378:metabolism*
D000588:Amines; D002273:Carcinogens; D007093:Imidazoles; D009153:Mutagens; C023847:Glu-P-2
Etude du rôle de la flore intestinale humaine dans l'activation métabolique des produits de pyrolyse.