A case of lactate dehydrogenase (LDH)-IgG complex formation which causes low plasma LDH activity and an abnormal LDH isozyme pattern.
A case of an LDH-IgG complex formation which causes low plasma LDH activity and an abnormal LDH isozyme pattern was reported. A patient had pericarditis and myocardial hypertrophy of asymmetrical septal hypertrophy type. The same IgG was recognized in pericardial effusion. From a column chromatographic study, the molecular weight of LDH-IgG complex was estimated as being about 490,000. This complex was speculated as the IgG1-LDH2. The mechanism by which LDH-IgG is formed and the relationship between the complex itself and cardiac diseases remain unknown.
D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis; D006332:Cardiomegaly / Q000201:enzymology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis* / Q000378:metabolism; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood* / Q000172:deficiency; D008297:Male; D010493:Pericarditis / Q000201:enzymology*
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase