Effect of immuno-modulating agents on murine IL-2 production.
The effect of two Chinese traditional drugs, Dang Gui injection prepared from Angelica sinensis and C 21 Ester glucoside (GB) extracted from Cynanchus auriculatus on in vitro production of IL-2 has been studied. The IL-2 was produced by Con A stimulation of mouse spleen mononuclear cells. The IL-2 activity was assayed using Con A stimulated blast cells as the target. It was found that Dang Gui increased and GB decreased the production of IL-2. In the control experiments for immuno-modulating effect, prostaglandin E2 (PGE2) was found to suppress and indomethacin to increase IL-2 production. The stimulatory effect of Dang Gui was totally abrogated by PGE2.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D015232:Dinoprostone; D006801:Humans; D007213:Indomethacin / Q000276:immunology / Q000494:pharmacology; D007376:Interleukin-2 / Q000096:biosynthesis*; D008516:Medicine, Chinese Traditional; D008518:Medicine, East Asian Traditional; D010936:Plant Extracts / Q000276:immunology; D010946:Plants, Medicinal / Q000276:immunology*; D011458:Prostaglandins E / Q000276:immunology / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000166:cytology; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects; D014165:Transfer Factor / Q000276:immunology / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D007376:Interleukin-2; D010936:Plant Extracts; D011458:Prostaglandins E; D014165:Transfer Factor; D015232:Dinoprostone; D007213:Indomethacin