title: A comparison of the responses of staphylococci and streptococci to teicoplanin and vancomycin.
abstract: Continuous turbidimetric monitoring of cultures of staphylococci and streptococci exposed to teicoplanin or vancomycin revealed considerable inhibitory activity at concentrations below the conventionally-determined minimum inhibitory concentration. Teicoplanin was more active than vancomycin against low inocula, but exhibited a larger inoculum effect. A modest decline in susceptibility to teicoplanin and vancomycin could be induced by sequential exposure to the drugs. Such variants gradually reverted to susceptibility on passage in antibiotic-free broth. The morphological consequences of exposure to the two antibiotics were similar as judged by scanning electron microscopy.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006020:Glycopeptides / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009391:Nephelometry and Turbidimetry; D013210:Staphylococcus / Q000187:drug effects* / Q000648:ultrastructure; D013291:Streptococcus / Q000187:drug effects* / Q000648:ultrastructure; D017334:Teicoplanin; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D017334:Teicoplanin; D014640:Vancomycin