Immune alterations in hemodialyzed patients. I. Effect of blood transfusion on T-lymphocyte subpopulations in hemodialyzed patients.
The immune status in 42 patients with end-stage renal failure on maintenance hemodialysis was studied by using monoclonal antibodies to lymphocyte subpopulations. Lymphopenia, reductions in the proportion of OKT4+ cells and OKT4+/OKT8+ cell ratio were observed in hemodialyzed patients. These alterations in immune status were observed in 34 transfused patients, but not in 8 patients without history of blood transfusion. The proportion of OKT8+ cells was increased in patients with history of blood transfusion. When transfused patients were divided according to the dose of blood transfused in the last 2 yr, the most serious change was observed in those who received greater than 10 u of transfusion. The dose of blood transfused in the last 2 yr correlated positively with the proportion of OKT8+ cells (p less than 0.01) and inversely with OKT4+/OKT8+ cell ratio (p less than 0.05). The duration of hemodialysis did not affect the alterations in immunoregulatory cells. These results indicate that alterations in immune features in hemodialyzed patients may be linked to the history of blood transfusion rather than that of uremia and/or hemodialysis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D001803:Blood Transfusion; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D007676:Kidney Failure, Chronic / Q000097:blood / Q000276:immunology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013601:T-Lymphocytes / Q000032:analysis / Q000145:classification*; D013602:T-Lymphocytes, Cytotoxic / Q000032:analysis; D006377:T-Lymphocytes, Helper-Inducer / Q000032:analysis; D014511:Uremia / Q000097:blood / Q000276:immunology / Q000628:therapy
D000911:Antibodies, Monoclonal