Metabolism of (n-6) and (n-3) polyunsaturated fatty acids by human platelets.
Human platelets metabolize 7,10,13,16-docosatetraenoic acid and 4,7,10,13,16-docosapentaenoic acid into 22-carbon thromboxanes 19-carbon HHT analogs and 14-hydroxy fatty acids via the lipoxygenase pathway. Conversely the two analogous (n-3) acids, 7,10,13,16,19-docosapentaenoic acid and 4,7,10,13,16,19-docosahexaenoic acid, are metabolized only into a pair of isomeric 11- and 14-hydroxy fatty acids. These findings suggest that platelets may contain more than one lipoxygenase.
D001792:Blood Platelets / Q000201:enzymology* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004281:Docosahexaenoic Acids; D004883:Erucic Acids / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007536:Isomerism; D008084:Lipoxygenase / Q000502:physiology; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology
D004883:Erucic Acids; D005231:Fatty Acids, Unsaturated; C011395:adrenic acid; D004281:Docosahexaenoic Acids; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; C026219:docosapentaenoic acid; D007213:Indomethacin