Pilocarpine-induced purposeless chewing behaviour in rats is dependent on intact central stores of 5-HT.
Pilocarpine-induced purposeless chewing behaviour in rats was partially antagonised by pretreatment with reserpine, tetrabenazine or p-chlorophenylalanine (PCPA). In contrast, pretreatment with alpha-methyl-p-tyrosine (AMPT) had no effect on pilocarpine-induced chewing. These data suggest that enhancement of purposeless chewing by pilocarpine is dependent, in part, on intact central stores of 5-HT.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D008409:Mastication / Q000187:drug effects*; D008781:Methyltyrosines / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology*; D013747:Tetrabenazine / Q000494:pharmacology; D019805:alpha-Methyltyrosine
D001679:Biogenic Amines; D008781:Methyltyrosines; D010862:Pilocarpine; D012701:Serotonin; D019805:alpha-Methyltyrosine; D012110:Reserpine; D010134:Fenclonine; D013747:Tetrabenazine