Fatal hepatic necrosis due to pyrimethamine-sulfadoxine (Fansidar).
Pyrimethamine-sulfadoxine has been associated with severe and fatal cutaneous reactions as well as transient liver damage. We report the case of a patient who died of progressive hepatic failure caused by pyrimethamine-sulfadoxine administration. In addition, we summarize reports made to the Food and Drug Administration since 1982 that focus on hepatotoxic reactions to pyrimethamine-sulfadoxine. We suggest that fatal hepatic injury can occur after treatment with pyrimethamine-sulfadoxine and that physicians who prescribe the drug should be aware of this possibility.
D000293:Adolescent; D056486:Chemical and Drug Induced Liver Injury; D003873:Dermatitis, Exfoliative / Q000139:chemically induced; D004338:Drug Combinations / Q000009:adverse effects; D004484:Ecuador; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000473:pathology; D008111:Liver Function Tests; D008288:Malaria / Q000517:prevention & control; D009336:Necrosis; D011739:Pyrimethamine / Q000009:adverse effects*; D013413:Sulfadoxine / Q000009:adverse effects*; D013424:Sulfanilamides / Q000009:adverse effects*; D014195:Travel
D004338:Drug Combinations; D013424:Sulfanilamides; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011739:Pyrimethamine