Serial studies of T-lymphocyte subpopulations in HIV seropositive haemophiliacs.
Serial determinations of the numbers of peripheral blood T-lymphocyte subpopulations (T-helper/inducer and T-suppressor/cytotoxic cells) were made using monoclonal antibodies in 12 patients with haemophilia who were HIV antibody positive. Eleven patients were clinically severe and one clinically moderate. Follow-up studies for 12-42 months in nine patients showed persisting abnormalities in five patients, abnormalities which developed in three patients who were initially normal, and a return to normal findings in one patient who was initially abnormal. The remaining three patients were followed up for 3-4 months; two showed persisting abnormalities and one a return to normal. Persistent generalized lymphadenopathy was found in one patient who showed raised levels of T-suppressor cells initially and low levels of T-helper cells in the follow-up, but low T-helper cells persisting for up to 12 months were not necessarily associated with disease.
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral / Q000032:analysis*; D005500:Follow-Up Studies; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies; D006467:Hemophilia A / Q000276:immunology*; D006801:Humans; D008206:Lymphatic Diseases / Q000175:diagnosis / Q000276:immunology; D008297:Male; D013601:T-Lymphocytes / Q000145:classification* / Q000166:cytology / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D015483:HIV Antibodies