[In vitro study of delta-6- and delta-5-desaturation of linoleic and dihomo-gamma-linolenic acids in WKY rats on a high-sodium diet].
Delta 6- and delta 5-desaturation activities of linoleic [1(4)C] and dihomo-gamma-linolenic [2(14)C] acids are increased, in vitro, in liver microsomes of normotensive rats WKY, which receive an hypernatriuric diet (NaCl 3%). These results lead to a best known of delta 6- and delta 5-desaturases, which are involved in fundamental steps of linoleic acid metabolites biosynthesis, implicated in blood pressure regulation.
D015126:8,11,14-Eicosatrienoic Acid / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure; D000090943:Delta-5 Fatty Acid Desaturase; D004032:Diet; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000378:metabolism*; D050602:Linoleoyl-CoA Desaturase; D050356:Lipid Metabolism; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D011921:Rats, Inbred WKY; D012965:Sodium Chloride / Q000008:administration & dosage*; D013997:Time Factors
D000090943:Delta-5 Fatty Acid Desaturase; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D012965:Sodium Chloride; D019787:Linoleic Acid; D044943:Fatty Acid Desaturases; D050602:Linoleoyl-CoA Desaturase; D015126:8,11,14-Eicosatrienoic Acid
Etude in vitro des delta 6- et delta 5-désaturations des acides linoléique et dihomo-gamma-linolénique chez le rat WKY soumis à un régime hypersodé.