Laparoscopic findings and hormonal patterns in the treatment of endometriosis by danazol.
The authors have studied, in 120 women with sterility, the incidence of endometriosis in the laparoscopic diagnostics, the development of pathology after the treatment by Danazol alone (600 mg/daily/6 months) or preoperative Danazol and subsequent conservative surgery, the sera RIA levels of FSH, LH, PRL, 17 beta-oestradiol and progesterone during therapy, the pelvic findings in the laparoscopic second look and the pregnancy rates after the treatment. On the findings of the obtained results, which agree with the most recent studies, the authors point out the significance of laparoscopy in the diagnosis and staging of endometriosis; the correlation between staging and different therapies; the peculiarity of the laparoscopic second look in monitoring endometriosis evolution after therapy and at last the deep correlations, not yet well explained, among the mild endometriosis and alterations as the luteal phase defect and the anovulatory both in the acute fitness of the pathology and after treatment by Danazol alone or preoperative Danazol with subsequent conservative surgery as shown by persistence of sterility or of infertility, although without other well-known reasons which could explain the subsequent pregnancy failures.
D000328:Adult; D003613:Danazol / Q000627:therapeutic use*; D004715:Endometriosis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy / Q000209:etiology; D010535:Laparoscopy; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011245:Pregnadienes / Q000627:therapeutic use*; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood
D011245:Pregnadienes; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003613:Danazol