Indomethacin in streptozocin-induced nephrogenic diabetes insipidus.
A 14-year-old female patient with metastatic carcinoid developed streptozocin-induced glomerular, proximal, and distal tubular dysfunction. The latter was in the form of nephrogenic diabetes insipidus, with urine volumes in excess of 11 L/24 h. The prostaglandin synthetase inhibitor, indomethacin, rapidly corrected the polyuria both initially and on rechallenge, independent of change in glomerular filtration rate.
D000284:Administration, Oral; D000293:Adolescent; D003919:Diabetes Insipidus / Q000139:chemically induced*; D004341:Drug Evaluation; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000139:chemically induced*; D011141:Polyuria / Q000139:chemically induced; D013311:Streptozocin / Q000009:adverse effects*
D013311:Streptozocin; D007213:Indomethacin