title: [Dependence of the specific activity of an immunoglobulin against tick-borne encephalitis on the degree of its fragmentation].
abstract: Immunoglobulin preparations against tick-borne encephalitis with the increasing content of Fab-fragments (from 16% to 45%) have been experimentally obtained. As revealed by testing these samples in vivo for specific activity (in the biological neutralization test), the preparations containing 16% of Fab-fragments show no perceptible decrease of specific activity; its sharp decrease (2-16 times) can be observed in preparations with a high degree of fragmentation (the content of Fab-fragments being equal to 30-45%).
mesh_terms: D000818:Animals; D002855:Chromatography, Thin Layer; D004675:Encephalitis, Tick-Borne / Q000276:immunology*; D005341:Fibrinolysin / Q000494:pharmacology; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000032:analysis / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D051379:Mice; D008970:Molecular Weight; D009500:Neutralization Tests; D013997:Time Factors
chemical_list: D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D005341:Fibrinolysin
vernacular_title: Izuchenie zavisimosti spetsificheskoĭ aktivnosti immunoglobulina protiv kleshchevogo éntsefalita ot stepeni ego fragmentatsii.