The effect of endotoxin on peripheral blood lymphocytes in the rat.
We have studied the effects on peripheral blood lymphocytes of the administration to rats of a single dose of endotoxin. Lymphopenia occurred during the first hour, and persisted during 24 hours. Lymphocyte subpopulations were examined by flow cytometry. T-lymphocytes were relatively resistant to the initial effects of endotoxin, but there were no differences in the responses of cells identified as T-helper or T-suppressor/cytotoxic lymphocytes. The effects of endotoxin on peripheral blood lymphocytes is less extreme but appears more persistent than the effects on granulocytes.
D000818:Animals; D004731:Endotoxins / Q000494:pharmacology*; D005260:Female; D007958:Leukocyte Count; D008214:Lymphocytes / Q000166:cytology*; D051381:Rats; D011919:Rats, Inbred Strains; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology
D004731:Endotoxins