title: Evaluation of polylactic acid-carbon mesh for repair of ventral herniorrhaphy.
abstract: Large ventral hernias are a difficult surgical problem. Previous attempts to repair large defects in the abdominal wall with prostheses have been associated with recurrences and infection. A filamentous polylactic acid-carbon tissue mesh is a possible alternative prosthesis. We evaluated and compared polylactic acid-carbon mesh and Marlex mesh in repairing a large defect of the abdominal wall in a rat model. The polylactic acid-carbon mesh led to as strong a repair as Marlex mesh for the same time periods postoperatively; furthermore, no infection was noted with the former, whereas a 5.3 percent incidence of infection was noted with Marlex mesh. One mesh disruption was also noted with Marlex mesh. Polylactic acid-carbon mesh was found to have a more marked fibrotic response and a lesser inflammatory response. Polylactic acid-carbon mesh, therefore, appears to be more biocompatible, with more fibrosis, less inflammatory reaction, and equal strength to Marlex mesh. It is therefore a more appropriate synthetic material for a large ventral herniorrhaphy.
mesh_terms: D000009:Abdominal Muscles / Q000503:physiopathology / Q000601:surgery; D000818:Animals; D002244:Carbon; D017554:Carbon Compounds, Inorganic; D006555:Hernia, Ventral / Q000503:physiopathology / Q000601:surgery*; D007773:Lactates; D019344:Lactic Acid; D011095:Polyethylenes; D011108:Polymers; D011126:Polypropylenes; D019736:Prostheses and Implants; D051381:Rats; D011919:Rats, Inbred Strains; D013314:Stress, Mechanical; D013526:Surgical Mesh; D014945:Wound Healing
chemical_list: D017554:Carbon Compounds, Inorganic; D007773:Lactates; C016674:Plastipore; D011095:Polyethylenes; D011108:Polymers; D011126:Polypropylenes; C031979:carbon-polylactic acid polymer; D019344:Lactic Acid; D002244:Carbon