Expression of trophoblast-leukocyte common antigens and placental-type alkaline phosphatase in complete molar pregnancy.
The current study was undertaken to determine the localization of trophoblast-leukocyte common antigens and placental-type alkaline phosphatase in complete molar pregnancy with the use of rabbit antiserum and murine monoclonal antibodies in immunofluorescence assays. Trophoblast-leukocyte common antigens were expressed on all normal villous trophoblast (8 to 38 weeks' gestation) and on all complete moles studied. Placental-type alkaline phosphatase was not expressed on villous trophoblast before 20 weeks' gestation in either normal placentas or complete moles. In contrast, there was strong expression of placental-type alkaline phosphatase on villous trophoblast of normal placentas of more than 20 weeks' gestational age. The expression of polymorphic antigens such as trophoblast-leukocyte common antigens and placental-type alkaline phosphatase on molar trophoblast may be important in the immunobiologic features of gestational trophoblastic disease.
D000469:Alkaline Phosphatase / Q000032:analysis*; D000911:Antibodies, Monoclonal; D005260:Female; D005455:Fluorescent Antibody Technique; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D006828:Hydatidiform Mole / Q000201:enzymology / Q000276:immunology*; D017493:Leukocyte Common Antigens; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D014327:Trophoblasts / Q000276:immunology*; D014594:Uterine Neoplasms / Q000201:enzymology / Q000276:immunology*
D000911:Antibodies, Monoclonal; D006649:Histocompatibility Antigens; D000469:Alkaline Phosphatase; D017493:Leukocyte Common Antigens