[Effect of sodium selenite on the antitumor function of spleen lymphocytes in mice].
Sodium selenite in drinking water (1 ppm) was given to normal and hepatoma-bearing mice for 14 days. Spleen lymphocytes were incubated with hepatoma cells and 3H-TdR incorporation was measured. Sodium selenite increased the ability of spleen cells to inhibit 3H-TdR incorporation into hepatoma cells by more than 40%. In the meantime, in the spleen lymphocytes of normal and hepatoma-bearing mice, the activities of ATPase, acid phosphatase and alkaline phosphatase were definitely higher than that of the control (ATPase increased by 35.5% and 65.0%; acid phosphatase increased by 113.0% and 93.0%; alkaline phosphatase by 64.7% and 69.0%, respectively). These results suggest that sodium selenite (1 ppm), like immunologic stimulator such as bacillus Calmette Guérin (BCG), be able to stimulate the immunologic function of organism against hepatoma.
D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D007111:Immunity, Cellular / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000276:immunology* / Q000473:pathology; D008214:Lymphocytes / Q000201:enzymology / Q000276:immunology*; D008297:Male; D051379:Mice; D012643:Selenium / Q000494:pharmacology*; D018036:Selenium Compounds; D013154:Spleen / Q000276:immunology
D018036:Selenium Compounds; C037341:sodium selenide; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases; D012643:Selenium