Suppression of the murine anti-trimellityl (TM) IgE response: induction of B cell tolerance by conjugates of TM and polyvinyl alcohol.
It was previously shown that administration of conjugates of trimellitic anhydride with polyvinyl alcohol (TM-PVA) could suppress the IgE anti-TM immune response of mice sensitized with a TM-ovalbumin conjugate. In the present study, the existence of TM-specific B cell tolerance was shown by cell transfer experiments in which splenic B cells from mice treated with TM-PVA failed to interact with either the helper T (Th) cells of carrier primed recipients or with Th cells derived from carrier-primed donors. In contrast to previous findings from this laboratory indicating that tolerogenic conjugates of PVA and the 2,4-dinitrophenyl group led to both B cell tolerance and activation of suppressor T (Ts) cells, no evidence was obtained for the induction of Ts cells by TM-PVA. Thus, the induction of demonstrable Ts cells by hapten-PVA conjugates may depend on some property conferred by the haptenic group.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology; D005260:Female; D007108:Immune Tolerance; D007116:Immunization, Passive; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D010795:Phthalic Acids / Q000276:immunology*; D010796:Phthalic Anhydrides / Q000276:immunology* / Q000494:pharmacology; D011142:Polyvinyl Alcohol / Q000494:pharmacology*; D011828:Radiation Chimera; D051381:Rats; D013154:Spleen / Q000166:cytology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D002352:Carrier Proteins; D007166:Immunosuppressive Agents; D010795:Phthalic Acids; D010796:Phthalic Anhydrides; D007073:Immunoglobulin E; C015559:trimellitic anhydride; D011142:Polyvinyl Alcohol; D010047:Ovalbumin