title: Fibrinogen--proteolysis in acute myelogenous leukemia (AML).
abstract: Fibrinopeptides were measured as direct indices of thrombin, plasmin and elastase in plasma samples obtained from patients with AML. Peptide patterns observed were consistent with spontaneous or drug induced plasmin-specific fibrinogenolysis (AML FAB M 1/3), elastase mediated proteolysis (AML FAB M 3/4) or DIC (AML FAB 4/5). DIC was also observed in septic, agranulocytotic patients.
mesh_terms: D000328:Adult; D005337:Fibrin / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis / Q000378:metabolism*; D005341:Fibrinolysin / Q000032:analysis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000097:blood; D013917:Thrombin / Q000032:analysis / Q000378:metabolism
chemical_list: D005337:Fibrin; D005340:Fibrinogen; D010196:Pancreatic Elastase; D013917:Thrombin; D005341:Fibrinolysin