Defect of cellular suppressor function in the pathogenesis of type I diabetes mellitus.
In 29 out of 30 type I diabetic patients the peripheral blood lymphocytes induced an insulin release from isolated rat islets which was regarded as a cytotoxic effect, i.e. a model of beta cell destruction in diabetes mellitus. In 11 out of 12 cases, this effect was inhibited by the in-vitro addition of lymphocytes from healthy probands. Thus the activation of cytotoxic T-cells demonstrated by this observation might be the consequence of a defect in suppressor cell function. Consequently, the transfusion in vivo of lymphocytes from healthy probands strongly reduced the cytotoxic reaction of the lymphocytes from newly diagnosed diabetic recipients in vitro.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001803:Blood Transfusion; D002648:Child; D003602:Cytotoxicity, Immunologic; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D017710:Lymphocyte Transfusion; D051381:Rats; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D007328:Insulin