Hippocampal long-term potentiation increases mitochondrial calcium pump activity in rat.
45Ca2+ pump activity was measured in hippocampal homogenates after the induction of long-term potentiation (LTP) of perforant path-dentate gyrus synapses in vivo. The mitochondrial poison, sodium azide, was used to separate mitochondrial from non-mitochondrial 45Ca2+ uptake. High-frequency stimulation of the perforant path input produced a selectively increased mitochondrial uptake of calcium. This increased pump activity may permit granule cells to more effectively buffer higher intracellular calcium levels associated with LTP.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D004558:Electric Stimulation; D005071:Evoked Potentials; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D007700:Kinetics; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000502:physiology
D000252:Calcium-Transporting ATPases; D002118:Calcium