Effect of naltrexone on ethanol-provoked flushing in Oriental and white subjects.
The effect of naltrexone vs. placebo on alcohol-provoked flushing was studied in 20 healthy subjects of Oriental ancestry and 20 healthy white subjects. The intensity of the flushing reactions was assessed by two independent methods, the cutaneous perfusion index by laser Doppler velocimetry and the change in malar thermal circulation index by telethermometry. No effect of naltrexone on alcohol-provoked flushing was detected with either method in either racial group. The incidence of abdominal discomfort and nausea associated with naltrexone treatment was much greater among Orientals than whites.
D000328:Adult; D000884:Anthropology, Cultural; D000885:Anthropology, Physical; D044466:Asian People; D002160:Cambodia / Q000208:ethnology; D002681:China / Q000208:ethnology; D002986:Clinical Trials as Topic; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005483:Flushing / Q000139:chemically induced*; D006801:Humans; D007723:Korea / Q000208:ethnology; D008297:Male; D009271:Naltrexone / Q000494:pharmacology*; D010679:Philippines / Q000208:ethnology; D010919:Placebos; D012212:Rheology; D012867:Skin / Q000098:blood supply / Q000187:drug effects; D014481:United States; D014744:Vietnam / Q000208:ethnology; D044465:White People
D010919:Placebos; D000431:Ethanol; D009271:Naltrexone