IgG binding to endothelial cells in systemic lupus erythematosus.
Endothelial-associated IgG were determined in 20 patients with systemic lupus erythematosis (SLE)-8 of whom had a lupus anticoagulant (LA) and 6 a history of thrombosis. The binding of IgG present in patient plasma to cultured human endothelial cells was detected using radiolabeled staphylococcal protein A. Thirteen samples gave positive results and a significant association between endothelial-associated IgG and lupus anticoagulant was found (p less than 0.05). No statistically significant relationship with a previous history of thrombosis was found. These results suggest that the lupus anticoagulant may be directly involved in immune vascular injury induced by either antibodies or immune complexes in SLE.
D000293:Adolescent; D000328:Adult; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology; D002478:Cells, Cultured; D004727:Endothelium / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D016682:Lupus Coagulation Inhibitor; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D017452:Receptors, IgG; D011971:Receptors, Immunologic / Q000276:immunology*; D014471:Umbilical Veins
D001779:Blood Coagulation Factors; D007074:Immunoglobulin G; D016682:Lupus Coagulation Inhibitor; D017452:Receptors, IgG; D011971:Receptors, Immunologic