[Effect of modification of host immune activity on radiation therapy].
In this previous meeting, author reported that specific anti-tumor T cells, perhaps helper T cells, are induced in host mice after local irradiation to tumor. Immunostimulators were used following local irradiation to tumor. However, because suppressor T cells were also stimulated by these drugs, cyclophosphamide was used to suppress suppressor T cells. The results indicate that the combined use of immunostimulator and suppressor of suppressor T cells is very effective in radiation therapy. In the combined use of these drugs, the following three factors are very important: 1) whether the drug is administered before or after radiation, 2) the time interval between administrations of immunostimulator and suppressor T cells and local irradiation, and 3) dosage. Good effects were not obtained when dosage exceeded appropriate levels. The relationships among these factors are critical.
D000818:Animals; D001688:Biological Products / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D007108:Immune Tolerance; D008325:Mammary Neoplasms, Experimental / Q000276:immunology / Q000532:radiotherapy*; D051379:Mice; D008809:Mice, Inbred C3H; D010844:Picibanil / Q000627:therapeutic use*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D001688:Biological Products; D010844:Picibanil; D003520:Cyclophosphamide