title: Comments on subacute and long-term studies.
abstract: Long-term therapy with Duovent was always superior in comparison to the other drugs. An immediate efficacy with increasing levels until the 90th day was always obtained. There were no signs of tachyphylaxis and side effects were insignificant. Functional modifications were evident in the large and small airways.
mesh_terms: D000328:Adult; D000368:Aged; D001286:Atropine Derivatives / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004338:Drug Combinations / Q000627:therapeutic use; D005280:Fenoterol / Q000627:therapeutic use*; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use*; D008137:Longitudinal Studies; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D012115:Residual Volume; D013997:Time Factors; D014797:Vital Capacity
chemical_list: D001286:Atropine Derivatives; D004338:Drug Combinations; C030809:fenoterol, ipratropium drug combination; D005280:Fenoterol; D009241:Ipratropium