title: The effect of drugs used in anticoagulation therapy on T lymphocyte activation in vitro. II. Warfarin inhibits T lymphocyte activation.
abstract: The effect of warfarin on T lymphocyte activation in vitro was investigated. Warfarin was found to cause a dose-dependent inhibition of both antigen- and PHA-stimulated proliferation. The drug had to be present during the early steps in T lymphocyte activation to cause inhibition. Warfarin seemed to have no effect on antigen processing or presentation. Warfarin inhibited Interleukin 2 (IL-2) production, but had only minimal effects on expression of IL-2 receptors or IL-2 dependent proliferation. The inhibition in most in vitro models was found only at warfarin concentrations exceeding the therapeutic serum level.
mesh_terms: D000956:Antigens, Viral / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects*; D007959:Lymphocyte Culture Test, Mixed; D009109:Mumps virus / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013997:Time Factors; D014859:Warfarin / Q000009:adverse effects* / Q000276:immunology
chemical_list: D000956:Antigens, Viral; D007376:Interleukin-2; D010835:Phytohemagglutinins; D011971:Receptors, Immunologic; D014859:Warfarin