Effects of atrial natriuretic peptide on renin secretion in nonfiltering kidney.
Studies were performed in normal dogs (n = 6) and dogs with nonfiltering kidneys (n = 8) to determine the effects of synthetic atrial natriuretic peptide (ANP) on renin secretion and renal hemodynamics in the presence and absence of a functional macula densa. In normal dogs, intrarenal infusion of ANP (0.3 microgram X kg-1 X min-1) resulted in a decrease in renin secretion from 325.5 +/- 87.4 to 52.4 +/- 29.4 ng/ml, despite a sustained decrease in arterial pressure. In contrast, in the nonfiltering kidney without a functional macula densa, ANP infusion did not inhibit renin secretion in this nonfiltering model. Adenosine, however, known to directly inhibit renin secretion, did decrease renin secretion in this nonfiltering model. The present studies document that, in the nonfiltering kidney, ANP has no inhibitory effect on renin secretion.
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005919:Glomerular Filtration Rate; D007678:Kidney Glomerulus / Q000378:metabolism*; D012079:Renal Circulation / Q000187:drug effects; D012083:Renin / Q000378:metabolism*; D012964:Sodium / Q000652:urine; D014655:Vascular Resistance / Q000187:drug effects; D000092502:Renin Inhibitors
D000241:Adenosine; D009320:Atrial Natriuretic Factor; D012083:Renin; D012964:Sodium; D000092502:Renin Inhibitors