title: Allergic contact dermatitis from falcarinol isolated from Schefflera arboricola.
abstract: From the plant Schefflera arboricola, which has been reported to cause allergic contact dermatitis, we have isolated and determined the elicitor of allergic contact dermatitis as falcarinol, heptadeca-1,9(Z)-diene-4,6-diyne-3-ol. Three polyacetylenes closely related to falcarinol, namely falcarindiol, falcarinone and dehydrofalcarinone were tested simultaneously. Falcarinol, but not falcarindiol, falcarinone and dehydrofalcarinone, elicited allergic contact dermatitis in a 38-year-old female plant-nursery worker.
mesh_terms: D000328:Adult; D000480:Alkynes; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000139:chemically induced*; D053280:Diynes; D005233:Fatty Alcohols / Q000009:adverse effects*; D005260:Female; D006801:Humans; D010328:Patch Tests
chemical_list: D000480:Alkynes; D053280:Diynes; D005233:Fatty Alcohols; C018541:falcarinol