Progression of impaired glucose tolerance to diabetes mellitus in patients with primary glaucoma and ocular hypertension.
In 375 patients aged 68.5 +/- 9.4 years (mean +/- 1 SD) with primary glaucoma subdivided by irido-corneal angle configuration into closed-angle glaucoma (123 cases), ocular hypertension (186 cases), and open-angle glaucoma (66 cases), diabetic status was determined by standard 75 g oral glucose tolerance tests. In 63 patients with impaired glucose tolerance who were retested one year later, 16% had progressed to diabetes mellitus. The results confirm a significant association between non-insulin dependent diabetes mellitus and primary glaucoma which may result from autonomic dysfunction in parasympathetic tone causing anterior chamber angle closure.
D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D048909:Diabetes Complications; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005901:Glaucoma / Q000097:blood / Q000150:complications*; D005902:Glaucoma, Open-Angle / Q000097:blood / Q000150:complications*; D005951:Glucose Tolerance Test; D006801:Humans; D008875:Middle Aged; D009798:Ocular Hypertension / Q000150:complications*; D011379:Prognosis; D013997:Time Factors
D001786:Blood Glucose