title: [Human atrial natriuretic peptide: a secretory product of the heart and its significance for physiology and clinical practice].
abstract: This review deals with the physiological and clinical importance of human atrial natriuretic peptide (hANP). This peptide, which is produced by the myocardial cells of the right atrium, induces a diuretic and natriuretic response and has an inhibitory effect on aldosterone secretion. Recent elucidation of the peptide's structure represents the latest achievement in the search for an endogenous, natriuretic and hypotensive substance and has resulted in the publication of much, partly only preliminary data of its role within the homeostatic control of body sodium and water, as well as in various pathological disorders. The extensive literature is reviewed.
mesh_terms: D000450:Aldosterone / Q000096:biosynthesis; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D001794:Blood Pressure; D004231:Diuresis; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism*; D009318:Natriuresis
chemical_list: D000450:Aldosterone; D009320:Atrial Natriuretic Factor
vernacular_title: Humanes atriales natriuretisches Peptid: Ein Sekretionsprodukt des Herzens und seine Bedeutung für Physiologie und Klinik.