The role of gamma interferon in B-cell activation.
This study evaluates the role of gamma interferon in in vitro B-cell activation. Two clones of an alloreactive helper T-cell line were equally effective in activating B cells polyclonally to proliferate and to mature to immunoglobulin secretion. One of these clones produced high levels of gamma interferon, while the other clone did not. From these data we conclude that gamma interferon plays no limiting role in T-dependent B-cell activation.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D007074:Immunoglobulin G / Q000378:metabolism; D007157:Immunologic Surveillance / Q000187:drug effects; D007371:Interferon-gamma / Q000502:physiology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008222:Lymphokines / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology
D007074:Immunoglobulin G; D008222:Lymphokines; D007371:Interferon-gamma