Comparison of the effect of insulin hypoglycemia and clonidine on secretion of growth hormone, cortisol and beta-endorphin in children and adolescents.
Plasma beta-endorphin, human growth hormone (hGH) and cortisol were measured concomitantly during insulin hypoglycemia (0.1 u/kg i.v.) or clonidine administration (0.075 mg/m2 orally) in children with idiopathic short stature. Whereas hypoglycemia raised plasma beta-endorphin levels, clonidine slightly decreased beta-endorphin in six subjects and had no effect in four. Cortisol levels increased following hypoglycemia and decreased markedly after clonidine. hGH increased to greater than 20 ng/ml in all but one subject. The findings are interpreted as further evidence that the hGH stimulation of clonidine is not stress-mediated.
D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D003000:Clonidine / Q000494:pharmacology*; D004723:Endorphins / Q000378:metabolism*; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D013312:Stress, Physiological / Q000378:metabolism; D001615:beta-Endorphin
D001786:Blood Glucose; D004723:Endorphins; D007328:Insulin; D001615:beta-Endorphin; D013006:Growth Hormone; D003000:Clonidine; D006854:Hydrocortisone