Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization.
The chromosomal localization of a unique DNA fragment, closely linked to Huntington disease (HD), was assessed in situ by hybridization with 2-acetylaminofluorene (AAF) modified probes. In these experiments, a cosmid cloned genomic fragment (c5.5) was used for hybridization. Here we present evidence that confirms the mapping of the D4S10 locus to the p16 region of chromosome 4 and assigns it to the telomere of the short arm.
D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006816:Huntington Disease / Q000235:genetics*; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure; D009693:Nucleic Acid Hybridization
D005819:Genetic Markers; D004247:DNA