[Evaluation of hepatitis B vaccination in a Paris hospital personnel. 386 subjects].
Among 471 healthy Antoine Béclère hospital workers, (61 male, 410 female) 386 with no serological markers for hepatitis B virus (HBV) received three intramuscular doses of HEVAC B at intervals of 1 month. Ninety-three p. cent of vaccine recipients showed good antibody anti-HBs levels after the third injection. Fifty p. cent of subjects with no response after the third dose seroconverted after a booster dose. Vaccine responders' mean age (30 years) was lower than vaccine non responders' mean age (36 years). Anti-HBs antibody levels were significantly higher in women (P less than 0.001) and were independently correlated with age and sex. Two vaccine recipients developed anti-HBc in addition to anti-HBs, probably due to an HBV infection that occurred just before vaccination.
D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010297:Paris; D010564:Personnel, Hospital; D012189:Retrospective Studies; D014611:Vaccination
D006510:Hepatitis B Antibodies
Bilan de la vaccination contre l'hépatite B du personnel d'un hôpital parisien. 386 sujets.