Treatment of diabetic gastroparesis with oral domperidone.
Three patients with severe diabetic gastroparesis unresponsive to metoclopramide were found to have markedly prolonged gastric half-emptying times (t1/2) using a radionuclide-labelled test meal. They all showed symptomatic improvement and normal t1/2 within one week of taking oral domperidone 10 mg q.d.s. Oral domperidone may have a role in the treatment of severe diabetic gastroparesis particularly in metoclopramide-resistant cases.
D000284:Administration, Oral; D000328:Adult; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D004294:Domperidone / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010243:Paralysis / Q000188:drug therapy*; D013272:Stomach Diseases / Q000188:drug therapy*
D004294:Domperidone