Abnormal retinal function associated with fenretinide, a synthetic retinoid.
Five patients with basal cell carcinoma received fenretinide. Two patients while receiving the drug had evidence of abnormal rod photoreceptor function that reversed rapidly on cessation of therapy. We speculate that fenretinide may interfere with the binding of vitamin A to opsin or with the transport of vitamin A.
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000188:drug therapy; D002986:Clinical Trials as Topic; D003623:Dark Adaptation; D004596:Electroretinography; D005260:Female; D017313:Fenretinide; D006801:Humans; D008297:Male; D008875:Middle Aged; D010786:Photoreceptor Cells / Q000187:drug effects; D012160:Retina / Q000187:drug effects* / Q000503:physiopathology; D014212:Tretinoin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014786:Vision Disorders / Q000139:chemically induced / Q000503:physiopathology
D000970:Antineoplastic Agents; D017313:Fenretinide; D014212:Tretinoin