Immunogenetic composition of 94 consecutive Danish families investigated with respect to bone marrow transplantation.
The immunogenetic composition of 94 patients needing bone marrow transplantation and their core families primarily investigated to select family bone marrow donors have been further analysed to test for association between disease and HLA-region markers. From this material it is shown, that in the primary immunogenetic analysis of the family, inclusion of mixed lymphocyte culture analysis increases donor possibilities by approximately 14% when a reciprocal negative MLC response and phenotypic HLA-DR compatibility are accepted as criteria for transplantation. Further, the results indicate, that no association between HLA and leukemia seems to exist.
D000017:ABO Blood-Group System / Q000235:genetics / Q000276:immunology; D000741:Anemia, Aplastic / Q000235:genetics / Q000628:therapy; D001853:Bone Marrow / Q000276:immunology; D016026:Bone Marrow Transplantation; D003718:Denmark; D005191:Family Characteristics; D005260:Female; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006650:Histocompatibility Testing; D006720:Homozygote; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000628:therapy; D007938:Leukemia / Q000235:genetics / Q000628:therapy; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D010641:Phenotype; D014180:Transplantation / Q000401:mortality
D000017:ABO Blood-Group System; D006680:HLA Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II