Synthesis and antiinflammatory activity of 5-oxo-5H-1,3,4- thiadiazolo[3,2-a]pyrimidine-6-carboxamides.
A series of 5-oxo-5H-1,3,4-thiadiazolo[3,2-a]pyrimidine-6-carboxamides were synthesized and evaluated for antiinflammatory activity in the carrageenin oedema test and in RPAR in the rat. Some proved active in both tests. Two compounds, namely 2-(3-pyridyl)- and 2-morpholino-5-oxo-5H- 1,3,4-thiadiazole[3,2-a]pyrimidine-6-N-(2-pyridyl)carboxamide were particularly interesting.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D001183:Arthus Reaction / Q000517:prevention & control; D055598:Chemical Phenomena; D002621:Chemistry; D004487:Edema / Q000517:prevention & control; D051381:Rats; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013830:Thiadiazoles