[Male hypertestosteronemia].
Male hypogonadism is characterized by a lowering of plasma testosterone level below the lower limit of physiological variations. Conversely, some adult males, apparently eugonadic, have a plasma testosterone level much higher than normally. In most cases, male hypertestosteronaemia - defined by a plasma testosterone level above 13 ng/ml and due to various physiopathological mechanisms - is part of a wider pathological context. It betrays hyperandrogenism (elevated free testosterone) during treatment with androgens or chorionic gonadotropic hormone. In other cases, it seems to underlie a relative hypoandrogenism with rise of testosterone bound to transport proteins and/or excess of oestrogens. Hypertestosteronaemia therefore appears as a biochemical sign not to be ignored, but it also suggests that men with abnormally high testosterone levels present with new pathology and that aetiological investigations are necessary.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000502:physiology; D004700:Endocrine System Diseases / Q000097:blood / Q000209:etiology; D004958:Estradiol / Q000097:blood; D006177:Gynecomastia / Q000097:blood; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood; D007006:Hypogonadism / Q000097:blood; D008297:Male; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013737:Testis / Q000502:physiology; D013739:Testosterone / Q000008:administration & dosage / Q000097:blood* / Q000502:physiology
D006063:Chorionic Gonadotropin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol
Hypertestostéronémie masculine.