[Histamine receptor-bearing lymphocytes. V. Induction of suppressor cells with histamine or concanavalin A].
Immature human T-lymphocytes form rosettes with autologous erythrocytes (A-RFC). Con A induced suppressor cells in fractions of A-RFC. Mature, immunocompetent T-lymphocytes are non-A-RFC. They bear histamine receptors, and in such fractions histamine induced suppressor cells. After activation, both suppressor cells seem to be identical. They bear histamine receptors, Fe-receptors for IgG and the T8-antigen. For the expression of their suppressive effect the presence of monocytes is required.
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000276:immunology; D002448:Cell Adhesion / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000502:physiology; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D009000:Monocytes / Q000276:immunology / Q000502:physiology; D011961:Receptors, Fc / Q000276:immunology; D011968:Receptors, Histamine / Q000502:physiology*; D012397:Rosette Formation / Q000379:methods; D012756:Sheep; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000648:ultrastructure*
D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D011961:Receptors, Fc; D011968:Receptors, Histamine; D003208:Concanavalin A; D006632:Histamine
Histaminrezeptor-tragende Lymphozyten V. Induktion von Suppressorzellen durch Histamin oder Konkanavalin A.