[Treatment of neonatal infections: the place of cephalosporins].
The most commonly used antibiotic combination as a first-line treatment in neonates is ampicillin and an aminoglycoside. The increasing resistance of E. coli to ampicillin requires another choice. Good activity against group B Streptococci and E. coli, good CSF penetration and fewer side-effects are in favour of third generation cephalosporins as part of the antibiotic therapy. If a Listeria infection has not been excluded at the beginning of treatment, a triple combination may be given: ampicillin + third generation cephalosporin + aminoglycoside during the first 48 hours. The prognosis of enterobacterial meningitis has improved with third generation cephalosporins. As the other beta-lactam antibiotics, they modify the intestinal microbial ecosystem.
D001424:Bacterial Infections / Q000188:drug therapy* / Q000378:metabolism; D002511:Cephalosporins / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007231:Infant, Newborn; D013997:Time Factors
D002511:Cephalosporins
Traitement des infections néonatales: place des céphalosporines.