title: Dodecyl gallate, permitted in food, is a strong sensitizer.
abstract: Additives are now an established part of our packaged food. Some, like colouring agents and flavouring compounds are hardly necessary or even redundant. Others, mainly antimicrobials and antioxidants, are very important. Antioxidants are not only added to food, but also to cosmetics, pharmaceuticals and industrial products. Dodecyl gallate belongs with propyl- and octyl-gallate to the synthetic esters of gallic acid. These lipid-soluble phenols are very effective antioxidants. We found contact allergy in 4 of 10 workers having only limited contact with dodecyl gallate in the very low concentration of 0.05%. It is important to recognize its strong sensitizing capacity. Workers working with dodecyl gallate should avoid direct skin contact.
mesh_terms: D000328:Adult; D009783:Dermatitis, Occupational / Q000139:chemically induced*; D005260:Female; D005503:Food Additives / Q000009:adverse effects*; D005707:Gallic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012882:Skin Tests
chemical_list: D005503:Food Additives; C008259:lauryl gallate; D005707:Gallic Acid