T helper cell receptors: idiotypes and repertoire.
Idiotopes displayed by T cell receptors could be regulatory elements in the selection and maintenance of the T cell repertoire. Among these, of particular interest are those structures which allow receptor-receptor interactions between distinct T cell clonotypes. The existence of murine T lymphocytes which can be induced to proliferate by a monoclonal antibody specific for an allogeneic Class II antigen has been demonstrated. Such cells can interact with a fraction of the syngeneic T cells which react to the same alloantigen as the antibody. T cells involved in such an interaction were immortalized as IL-2 secreting T hybridomas. Functional and structural data suggest that some T cell idiotopes are internal images of MHC (Class II) epitopes, recognized by both alloreactive T lymphocytes and Ia specific antibodies. The relation between T cell receptor variable gene polymorphism and the predominance of a family of idiotopes indicates, on the other hand, the ability of a V beta gene family to participate in the encoding of receptors which exhibit a variety of antigen specificities. At least in one instance, topochemical resemblance between non-self antigens and self-MHC limits the T cell repertoire and gives rise to Ir gene controlled patterns of T cell responsiveness to nominal antigens.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006825:Hybridomas / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007376:Interleukin-2 / Q000378:metabolism; D008285:Major Histocompatibility Complex; D051379:Mice; D011110:Polymorphism, Genetic; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000911:Antibodies, Monoclonal; D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II; D007130:Immunoglobulin Idiotypes; D007376:Interleukin-2; D011948:Receptors, Antigen, T-Cell