title: Animal models utilized in the research of diabetes mellitus--with special reference to insulitis-associated diabetes.
abstract: Much experimental data on animal models of diabetes indicate the marked heterogeneity in the pathogenesis of this disease. Conversely, they also indicate that a single causal factor can develop highly diverse phenotypes of diabetes. For insulitis-associated diabetes, the NOD mouse and BB rat are particularly valuable because of the need for more research on the etiology of autoimmune-insulitis and in the search for methods to suppress this self-damaging process. insulitis-associated diabetes in animals including recent steps towards prevention of
mesh_terms: D000496:Alloxan; D000818:Animals; D002614:Chelating Agents; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology / Q000628:therapy; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000276:immunology; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin
chemical_list: D002614:Chelating Agents; D013311:Streptozocin; D000496:Alloxan