Inhibition of the sodium pump by cardioactive DPI 201-106.
The effects of DPI 201-106 were examined on contractions of papillary muscles from the right ventricle of feline heart, on [3H]-ouabain binding and Na+, K+-ATPase activity in feline ventricular membrane particles and on ouabain-sensitive 86Rb uptake in human erythrocytes. DPI 201-106 partially inhibited the Na+ pump at concentrations that caused pronounced positive inotropic effects.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002415:Cats; D066298:In Vitro Techniques; D010042:Ouabain / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D011868:Radioisotopes; D012413:Rubidium; D012964:Sodium / Q000378:metabolism*
D010879:Piperazines; D011868:Radioisotopes; D010042:Ouabain; C046261:DPI 201-106; D012964:Sodium; D000251:Adenosine Triphosphatases; D012413:Rubidium