[Activation of human granulocytes and monocytes by physiologic concentrations of thiocyanate (rhodanide)].
The lytic activity of human granulocytes or monocytes against hyperimmune-anti B-sensitized erythrocyte targets is enhanced after a twenty hours preincubation in the presence of physiological serum concentrations of thiocyanate. An analogous pretreatment of effector cells has no influence on antibody-dependent lymphocyte-mediated cytotoxicity. Concentrations of thiocyanate corresponding to those found in human serum are without any effects when the ion is added immediately before starting of cell-mediated erythrocyte lysis.
D000920:Antibody-Dependent Cell Cytotoxicity; D006098:Granulocytes / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*; D013861:Thiocyanates / Q000097:blood / Q000494:pharmacology*
D013861:Thiocyanates; C009941:potassium thiocyanate
Aktivierung humaner Granulozyten und Monozyten durch physiologische Konzentrationen an Thiocyanat (Rhodanid).