Effect of ginkgolide PAF-acether antagonists on arterial thrombosis.
Topical superfusion by PAF-acether over a branch of the mesenteric artery of the guinea pig invariably results in the formation of a platelet thrombus, adhering onto a denuded area of the vessel wall, or at sites where local retraction of the endothelial cells has occurred. It is demonstrated that the application of exogenous PAF-acether triggers a process of local autogeneration and release of endogenous PAF-acether (or PAF-like substances), maintaining a long phase of sequential regrowth and embolization of thrombi, eventually leading to a complete occlusion of the arterial lumen. Extracts of Ginkgo biloba, administered intravenously or in topical superfusion, inhibit both exogenous- and endogenous-induced thromboformation.
D000818:Animals; D004224:Diterpenes; D004617:Embolism / Q000209:etiology; D046934:Ginkgolides; D006168:Guinea Pigs; D007783:Lactones; D008297:Male; D008638:Mesenteric Arteries; D010936:Plant Extracts / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors* / Q000502:physiology; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control*
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010936:Plant Extracts; D010972:Platelet Activating Factor; C045856:ginkgolide B