title: Ferrous iron transport in Streptococcus mutans.
abstract: Radioiron uptake from 59FeCl3 by Streptococcus mutans OMZ176 was increased by anaerobiosis, sodium ascorbate, and phenazine methosulfate (PMS), although there was a 10-min lag before PMS stimulation was evident. The reductant ascorbate may have provided ferrous iron. The PMS was reduced by the cells, and the reduced PMS then may have generated ferrous iron for transport; reduced PMS also may have depleted dissolved oxygen. We conclude that S. mutans transports only ferrous iron, utilizing reductants furnished by glucose metabolism to reduce iron prior to its uptake.
mesh_terms: D000693:Anaerobiosis; D001205:Ascorbic Acid / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D005296:Ferrous Compounds / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000378:metabolism; D008773:Methylphenazonium Methosulfate / Q000494:pharmacology; D010084:Oxidation-Reduction; D017262:Siderophores; D013295:Streptococcus mutans / Q000187:drug effects / Q000378:metabolism*
chemical_list: D005296:Ferrous Compounds; D007502:Iron Chelating Agents; D017262:Siderophores; D008773:Methylphenazonium Methosulfate; D001205:Ascorbic Acid; C029451:ferrous chloride