[Neuroendocrine changes in the climacteric].
In order to investigate the relationship between hot flushes and LH-peaks, we applied GnRH-Analogon for pharmacological hypophysectomy. Although the gonadotropin serum levels could be normalized, none of the women showed a cessation of the flushes. Therefore it can be assumed that not gonadotropins, but neurotransmitters are involved in the development of flushes. The determination of the serum-level of vasointestinal peptide in the course of a TRH-test showed high VIP levels only in two climacteric women. To verify the suspected relation of VIP to the climacterium, a larger collective of women has to be checked.
D002979:Climacteric / Q000502:physiology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D007986:Luteinizing Hormone / Q000502:physiology*; D017329:Triptorelin Pamoate; D014660:Vasoactive Intestinal Peptide / Q000502:physiology*
D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D014660:Vasoactive Intestinal Peptide; D007986:Luteinizing Hormone
Neuroendokrine Veränderungen im Klimakterium.