Modulation of experimental phacoanaphylactic endophthalmitis with the antioxidants sodium benzoate, and 2,3-dihydroxybenzoic acid.
The antioxidants sodium benzoate and 2,3-dihydroxybenzoic acid reduced the inflammatory response in experimental phacoanaphylactic endophthalmitis. The 2,3-dihydroxybenzoic acid was by far the more effective antiphlogistic agent. The molecular mechanisms that may have contributed to the observed difference in antiphlogistic activity are discussed.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001565:Benzoates / Q000627:therapeutic use*; D019817:Benzoic Acid; D062385:Hydroxybenzoates / Q000627:therapeutic use*; D007105:Immune Complex Diseases / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D014605:Uveitis / Q000188:drug therapy* / Q000473:pathology
D000975:Antioxidants; D001565:Benzoates; D062385:Hydroxybenzoates; C009135:2,3-dihydroxybenzoic acid; D019817:Benzoic Acid