Intracellular turnover and cardiac hypertrophy.
Ultrastructural evidence is presented that intracellular autophagic degradation of cytoplasmic constituents is reduced during pressure induced hypertrophy of left ventricular myocardium after supravalvular aortic constriction in rats. This anti-catabolic reaction has to be considered as an important mechanism for shifting the balance between synthesis and degradation to the positive side. Short term studies after administration of isoproterenol suggest a close functional relationship between work load on the one hand and the anti-catabolic reaction on the other.
D000818:Animals; D001343:Autophagy; D006332:Cardiomegaly / Q000378:metabolism / Q000473:pathology*; D006321:Heart / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008854:Microscopy, Electron; D010587:Phagocytosis; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D011506:Proteins; D007545:Isoproterenol