[T lymphocyte subpopulations in anti-HIV-negative drug-dependent patients with intravenous abuse].
In the group of patients studied by us, we found a slight disturbance of the balance between immunoregulatory T helper/inductor lymphocytes and cytotoxic T suppressor lymphocytes which is usually characterised by a 2 to 1 ratio. This disturbance was due to the presence of an absolutely and relatively enhanced quantity of T suppressor cells, by which the relation of these T-cell subsets to each other was slightly lower than in the normal controls. The average ratio was 1.37 and was pathologically reduced in 19% of the patients. Activation and increase in the number of T suppressor cells in conjunction with a relative lymphocytosis are probably less due to a directly drug-induced effect than to an adequate immunoreaction to increased antigen stimuli such as infections with hepatitis B virus, viruses of the herpes group and other viral pathogens.
D000328:Adult; D005260:Female; D006679:HIV Seropositivity / Q000276:immunology*; D006556:Heroin Dependence / Q000276:immunology*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D012307:Risk Factors; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
T-Lymphozytensubpopulationen bei anti-HIV-negativen Drogenabhängigen mit intravenösem Missbrauch.