Neurotoxicity of quinolinate in the rat nucleus basalis magnocellularis.
Injections of quinolinic acid (QUIN) alone or combinations of QUIN with dipicolinic acid, Mg2+ or 3,4-diaminopyridine were made into the nucleus basalis magnocellularis of the rat. Choline acetyltransferase activity in the cortex decreased following injections of QUIN and this was antagonized by co-injections of QUIN with dipicolinic acid or Mg2+. Co-injections of QUIN with 3,4-diaminopyridine increased the neurotoxicity of quinolinic acid, while diaminopyridine alone was not toxic.
D015761:4-Aminopyridine / Q000031:analogs & derivatives*; D000077770:Amifampridine; D000631:Aminopyridines / Q000633:toxicity; D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects*; D002540:Cerebral Cortex / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002799:Cholinergic Fibers / Q000187:drug effects*; D007608:Kainic Acid / Q000633:toxicity; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D009434:Neural Pathways / Q000187:drug effects / Q000201:enzymology; D010848:Picolinic Acids / Q000633:toxicity*; D011725:Pyridines / Q000633:toxicity*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000633:toxicity*; D051381:Rats
D000631:Aminopyridines; D010848:Picolinic Acids; D011725:Pyridines; D011805:Quinolinic Acids; D015761:4-Aminopyridine; D002795:Choline O-Acetyltransferase; D017378:Quinolinic Acid; D008274:Magnesium; D000077770:Amifampridine; D007608:Kainic Acid; C004860:dipicolinic acid