Mating produced analgesia in the Syrian hamster.
A series of experiments examined the hypothesis that mating produced analgesia in the Syrian hamster can be blocked by opiate antagonists. The first experiment established a dose response relation to painful footshock. Females were more responsive to footshock than males (p less than 0.001). The second experiment demonstrated that ten minutes of mating reduced responsiveness of both males and females to a moderate intensity of footshock. The third experiment replicated the effect of mating on the responsiveness of males to footshock, but did not demonstrate any effect of the opiate antagonist naltrexone on mating induced analgesia. The fourth experiment demonstrated that limited mating stimulation (five intromissions) has little effect on the responsiveness of sexually inexperienced males to footshock. The fifth experiment replicated the fourth experiment using sexually experienced males and obtained comparable results. Apparently mating induced analgesia in male hamsters is not blocked by opiate antagonists and which raises questions about biological activity of reported changes in endorphin activity during mating.
D000818:Animals; D003307:Copulation / Q000502:physiology*; D006224:Cricetinae; D004597:Electroshock; D004723:Endorphins / Q000502:physiology*; D005260:Female; D008297:Male; D008647:Mesocricetus; D009271:Naltrexone / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D012727:Sex Characteristics; D001615:beta-Endorphin
D004723:Endorphins; D009271:Naltrexone; D001615:beta-Endorphin