[Kinetic study of antitumor lymphocyte cytotoxicity in rats bearing progressive or regressive syngeneic colonic tumors].
In order to perform a kinetic study of the antitumor lymphocyte-mediated cytotoxicity in syngeneic BDIX rats bearing progressive (TRb) or regressive (TSb) colonic tumors, the 51Cr release assay was adapted to this experimental model. Two groups of 72 rats were inoculated with TRb or TSb cells. Results failed to show any clear and univocal evolution of lymphocyte cytotoxicities against TRb or TSb cells. On the other hand these cytotoxicities were roughly at the same level than natural cytotoxicity (normal rats), and were always higher against TSb than TRb cells.
D000230:Adenocarcinoma / Q000276:immunology* / Q000473:pathology; D000818:Animals; D002460:Cell Line; D003110:Colonic Neoplasms / Q000276:immunology* / Q000473:pathology; D003602:Cytotoxicity, Immunologic; D007700:Kinetics; D008214:Lymphocytes / Q000276:immunology*; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D014185:Transplantation, Isogeneic
Etude cinétique de la cytotoxicité lymphocytaire antitumorale chez des rats porteurs de tumeurs coliques syngéniques progressives ou régressives.