Harmine reverses the inhibition of lordosis by the 5-HT2 antagonists pirenperone and ketanserin in the female rat.
The beta-carboline harmine was found to facilitate lordosis behavior in ovariectomized rats primed with estradiol benzoate. Moreover, harmine reversed the inhibition of lordosis by the serotonin type 2 (5-HT2) antagonists pirenperone and ketanserin in rats primed with estradiol benzoate and progesterone. These results suggest that harmine facilitates lordosis by enhancing activity at 5-HT2 receptors.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006247:Harmine / Q000494:pharmacology*; D007650:Ketanserin; D010052:Ovariectomy; D010880:Piperidines / Q000037:antagonists & inhibitors*; D011187:Posture; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D000470:Alkaloids; D010880:Piperidines; D011985:Receptors, Serotonin; D006247:Harmine; D011374:Progesterone; D004958:Estradiol; D007650:Ketanserin; C034177:pirenperone