[Extracellular ATP potentiates the secretion of insulin induced by tolbutamide].
Our experiments were carried out on the isolated perfused rat pancreas. The effect of extracellular ATP (8 microM) on insulin secretion induced by tolbutamide (0.04 mM) was studied in the presence of substimulating glucose concentration 4.2 mM (0.75 g/l). ATP (8 microM), ineffective per se at this concentration, highly potentiated the insulin secretion induced by tolbutamide (0.04 mM).
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D004357:Drug Synergism; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D000255:Adenosine Triphosphate
L'ATP extracellulaire potentialise la sécrétion d'insuline induite par le tolbutamide.