Pharmacokinetics of single dose intravenous ciprofloxacin in patients undergoing gastrointestinal surgery.
The pharmacokinetics of single dose intravenous ciprofloxacin in patients undergoing gastrointestinal surgery (100 mg, n = 8; 200 mg n = 18) have been studied. Following 100 mg therapeutic serum levels were maintained for approximately 40 min only and tissue concentrations were frequently less than 0.15 mg/kg. 200 mg maintained therapeutic serum levels for at least 150 min and produced mean concentrations in fat, muscle, peritoneum and gut wall of 1.04, 1.94, 1.59, and 3.39 mg/kg respectively. 200 mg iv ciprofloxacin would appear to provide adequate serum and tissue concentrations for at least 150 min.
D000009:Abdominal Muscles / Q000032:analysis; D000368:Aged; D001646:Bile / Q000032:analysis; D002939:Ciprofloxacin / Q000097:blood / Q000378:metabolism*; D004064:Digestive System / Q000378:metabolism; D013505:Digestive System Surgical Procedures; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010537:Peritoneum / Q000032:analysis; D014018:Tissue Distribution
D002939:Ciprofloxacin