title: [Pharmacology of the plant polyphenol epigalokhin].
abstract: Polymer proanthocyanidin from Rhodiola semenovii named epihalochin was found to exhibit a pronounced antihypoxic effect in different models of hypoxia (hypoxic, cytotoxic and hemic), to relieve the hypoxic isolated heart contracture. Therapeutic doses of epihalochin produced a transient lowering of arterial pressure, decreased to a certain degree heart rate and lengthened the phases of cardiac contractions.
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D001704:Biopolymers; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D000860:Hypoxia / Q000188:drug therapy; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009200:Myocardial Contraction / Q000187:drug effects; D010946:Plants, Medicinal; D011108:Polymers / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D013315:Stress, Psychological / Q000188:drug therapy; D014610:Uzbekistan
chemical_list: D000872:Anthocyanins; D001704:Biopolymers; D011108:Polymers; C048973:epihaloquine
vernacular_title: K farmakologii rastitel'nogo polifenola épigalokhina.