Immunologic studies in identical twins concordant for juvenile rheumatoid arthritis but discordant for monoclonal gammopathy and amyloidosis.
Identical twins concordant for juvenile rheumatoid arthritis but discordant for monoclonal gammopathy and amyloidosis were the subjects of a study done with mixed leukocyte culture, anti-idiotypic antisera against serum and urinary M component from the amyloid-affected twin, and in vitro estimations of M-component idiotype synthesis by peripheral blood mononuclear cells. Immunohistochemical analysis of renal amyloid deposits in the affected twin showed AL amyloid of the lambda-II variable region subgroup. M-component idiotypes were confined only to the twin with serum and urine M components.
D000328:Adult; D000596:Amino Acids / Q000032:analysis; D000682:Amyloid / Q000378:metabolism; D000686:Amyloidosis / Q000150:complications / Q000276:immunology*; D000954:Antigens, Surface / Q000032:analysis; D001171:Arthritis, Juvenile / Q000150:complications / Q000276:immunology*; D001536:Bence Jones Protein / Q000235:genetics; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000032:analysis; D007668:Kidney / Q000378:metabolism; D007959:Lymphocyte Culture Test, Mixed; D010265:Paraproteinemias / Q000150:complications / Q000276:immunology*; D014427:Twins; D014430:Twins, Monozygotic
D000596:Amino Acids; D000682:Amyloid; D000954:Antigens, Surface; D007130:Immunoglobulin Idiotypes; D001536:Bence Jones Protein