Response to anticoagulant drug withdrawal.
This study evaluated 44 separate medication withdrawal periods in 17 subjects who were attending a hospital anticoagulation clinic for management of anticoagulation medication. The data suggest that when anticoagulant withdrawal is needed for particular dental procedures, a 2-day hold is an effective period of medication withdrawal. No thromboembolic events were observed after any of the withdrawal periods. Further, no posttreatment hemorrhagic episodes were observed when the anticoagulant medication was reinstituted after dental treatment. Prothrombin time blood levels should be determined in the immediate pretreatment period, however, because the prothrombin time can fluctuate even in the best maintained patients.
D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000187:drug effects; D003730:Dental Care for Persons with Disabilities; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome; D013923:Thromboembolism / Q000139:chemically induced*; D013997:Time Factors; D014859:Warfarin / Q000009:adverse effects*
D001779:Blood Coagulation Factors; D014859:Warfarin