Occupational dermatitis in bakers: a clue for atopic contact dermatitis.
6 patients are described who developed contact dermatitis after cereal contact on atopic skin for periods of 2 to 20 years. 2 patients were wheat flour patch-test-positive. They had punch biopsies taken for standard histological and immunohistochemical investigation by labeling with monoclonal antibodies, anti-DR and anti-IgE. Sections showed features of contact dermatitis. There were many dendritic cells located perivascularly in the papilla and in the epidermidis, intensely positive for monoclonal anti-IgE antibody. In control atopic subjects, there were a few perivascular IgE positive cells, probably mastocytes. This study shows that there may be a relationship between some allergens and atopic eczema in patients exposed to them in the course of their work. In some cases, there was a true allergic contact dermatitis, seen through the clinical and histological characteristics, and the results of immunohistochemical study.
D000328:Adult; D001706:Biopsy; D003876:Dermatitis, Atopic / Q000276:immunology*; D009783:Dermatitis, Occupational / Q000209:etiology* / Q000276:immunology; D005433:Flour / Q000009:adverse effects*; D005511:Food Handling; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D012867:Skin / Q000473:pathology; D012882:Skin Tests; D014908:Triticum / Q000009:adverse effects*
D007073:Immunoglobulin E