[Study of magnet-controlled transport of curare-like preparations of diadonium and dipyronium in animal experiments].
The experiments on cats have shown that liposomes containing ferrocolloid and neuromuscular blocking agents (diadonium or dipyronium) cause selective muscle relaxation in the animal limb placed into the magnetic field, compared to the control limb kept outside the field. This effect was not related to the action of the magnetic field per se on neuromuscular transmission or the potency of neuromuscular blocking agents not contained in liposomes, but was induced by the accumulation of magnet-controlled liposomes in the target limb. The use of magnet-controlled liposomes for diadonium and dipyronium transport to one of the animal limbs decreases their unfavourable effect on respiratory muscle function.
D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000632:Aminopyrine / Q000031:analogs & derivatives*; D000818:Animals; D002415:Cats; D003102:Colloids; D004177:Dipyrone / Q000008:administration & dosage*; D007501:Iron; D008081:Liposomes / Q000008:administration & dosage*; D008280:Magnetics; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage*; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage*
D003102:Colloids; D008081:Liposomes; D003473:Neuromuscular Nondepolarizing Agents; D000644:Quaternary Ammonium Compounds; D000632:Aminopyrine; C013473:diadonium; D004177:Dipyrone; D007501:Iron; D000218:Adamantane
Izuchenie magnitoupravliaemogo transporta kurarepodobnykh preparatov diadoniia i dipironiia v éksperimentakh na zhivotnykh.