title: Clonidine in the treatment of premenstrual syndrome: a subgroup study.
abstract: The authors studied the effects of clonidine on a subgroup of women who had symptoms associated with premenstrual syndrome; the subgroup comprised 24 women aged 19 to 41 years who had "moderate" to "severe" cyclic decreases in beta-endorphin levels. All of the women received clonidine and placebo in a double-blind cross-over design that spanned four menstrual cycles. Clonidine was significantly (p less than .05) more effective than placebo in reducing symptoms.
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D003000:Clonidine / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D010919:Placebos; D011293:Premenstrual Syndrome / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D001615:beta-Endorphin / Q000097:blood
chemical_list: D010919:Placebos; D001615:beta-Endorphin; D003000:Clonidine