title: Anti-beta-endorphin immunoglobulin G in humans.
abstract: Human IgG specific for beta-endorphin was identified by enzyme-linked immunoabsorbent assay and isolated by affinity chromatography. From a sample of 27 subjects, three individuals with major depression demonstrated plasma IgG highly reactive with human beta-endorphin, while four other subjects (two with depression and two randomly selected blood donors) had intermediate reactivity. The recognition site for beta-endorphin was retained by F(ab')2 fragments.
mesh_terms: D000328:Adult; D002846:Chromatography, Affinity; D004723:Endorphins / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis* / Q000276:immunology / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000276:immunology; D009479:Neuropeptides / Q000276:immunology; D001615:beta-Endorphin
chemical_list: D004723:Endorphins; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D009479:Neuropeptides; D001615:beta-Endorphin