[Characteristics of the expression of globin genes in blood cells of patients with homozygotic beta-thalassemia from Tadzhikistan].
The synthesis of globin protein in blood reticulocytes of patients from Tajikistan suffering from homozygous beta-thalassemia was studied. Beta-thalassemia has been revealed in all cases, with synthesis of beta-globin being retained though essentially reduced. It was shown that, unlike homozygous beta+-thalassemia of other populations, beta +thalassemia with sharp inhibition of the beta-globin protein synthesis is most representative for the region (alpha/beta greater than 10).
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005914:Globins / Q000096:biosynthesis / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D010375:Pedigree; D013620:Tajikistan; D013789:Thalassemia / Q000097:blood / Q000235:genetics*
D005914:Globins
Izuchenie osobennosteĭ ékspressii globinovykh genov v kletkakh krovi bol'nykh gomozigotnoĭ beta-talassemieĭ iz Tadzhikistana.