title: Regulatory role of FcR+ and FcR- monocyte subsets in Mycobacterium leprae-induced lymphoproliferative response in vitro.
abstract: We investigated nine rhesus monkeys (Macaca mulatta) inoculated with Mycobacterium leprae and three normal human contacts. Peripheral blood monocytes were separated into Fc receptor positive (FcR+) and Fc receptor negative (FcR-) fractions, and their regulatory role in the lymphoproliferative response in vitro to M. leprae was studied. FcR- monocytes had strong antigen presentation activity and produced no suppressor effect while FcR+ monocytes had weak antigen presentation activity and produced a non-specific suppressor factor spontaneously. With this assay system we determined that M. leprae-inoculated rhesus monkeys could be divided into three groups: good responders, very weak responders, and non-responders.
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D005591:Chemical Fractionation; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007918:Leprosy / Q000276:immunology; D008213:Lymphocyte Activation; D008253:Macaca mulatta; D008297:Male; D009000:Monocytes / Q000145:classification* / Q000276:immunology; D009166:Mycobacterium leprae / Q000276:immunology; D011961:Receptors, Fc / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D011961:Receptors, Fc