The phospholipid contents in rat liver Golgi-rich membrane fractions after streptozotocin and/or prostaglandin treatment.
After dmPGE2 treatment, both alone or together with streptozotocin, the lower, statistically significant total PL contents (in mumoles P per mg of protein) in rat liver Golgi-rich membrane fractions were found. In these groups of investigated rats, the percentage of PE+PA were statistically significantly lower than in control. For the present it is impossible to certify, if there is a causal-result dependence between these two facts. The administration of streptozotocin alone (both after 6 or 11 days) caused the increase of PE+PA percentage, however not statistically significant.
D000818:Animals; D005260:Female; D006056:Golgi Apparatus / Q000032:analysis* / Q000187:drug effects; D008099:Liver / Q000032:analysis* / Q000187:drug effects / Q000648:ultrastructure; D008563:Membrane Lipids / Q000032:analysis*; D010743:Phospholipids / Q000032:analysis*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin / Q000494:pharmacology*
D008563:Membrane Lipids; D010743:Phospholipids; D011459:Prostaglandins E, Synthetic; C017244:16,16-dimethylprostaglandin E; D013311:Streptozocin