Prolonged neuromuscular blockade with atracurium.
During general anaesthesia with oxygen, nitrous oxide and enflurane, a 29-year-old woman received a total of 105 mg (1.78 mg X k-1) of atracurium over a 2.5 hour period. The neuromuscular blockade could not be completely reversed with neostigmine and mechanical ventilatory support was necessary for three hours postoperatively. The patient received succinylcholine without unusual sequelae before and after this episode. This is the first report of a patient who exhibited prolonged weakness after receiving atracurium.
D000328:Adult; D000768:Anesthesia, General; D001279:Atracurium; D004737:Enflurane; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000009:adverse effects*; D009123:Muscle Hypotonia / Q000139:chemically induced*; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000009:adverse effects*; D009609:Nitrous Oxide; D011229:Preanesthetic Medication; D013390:Succinylcholine; D013874:Thiopental; D013997:Time Factors; D014403:Tubocurarine
D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D001279:Atracurium; D004737:Enflurane; D013390:Succinylcholine; D013874:Thiopental; D009609:Nitrous Oxide; D014403:Tubocurarine