Some organic acids attenuate the effects of furosemide on the endocochlear potential.
A series of organic acid transport inhibitors significantly reduced the endocochlear potential (EP) decline produced by furosemide in the chinchilla. Probenecid, sodium salicylate and penicillin G were much more effective than novobiocin, meclofenamate or diatrizoate. Inhibitors of organic base transport, choline and N-methyl nicotinamide, had no effect on the furosemide-induced drop of the EP. These findings suggest that at least part of furosemide ototoxicity may be mediated by organic acid transport.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002264:Carboxylic Acids / Q000378:metabolism / Q000494:pharmacology*; D002682:Chinchilla; D002794:Choline / Q000494:pharmacology; D003055:Cochlear Microphonic Potentials / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005665:Furosemide / Q000037:antagonists & inhibitors* / Q000633:toxicity; D009536:Niacinamide / Q000031:analogs & derivatives / Q000494:pharmacology; D010400:Penicillin G / Q000494:pharmacology; D011339:Probenecid / Q000494:pharmacology; D012459:Salicylates / Q000494:pharmacology
D002264:Carboxylic Acids; D012459:Salicylates; D009536:Niacinamide; D005665:Furosemide; D002794:Choline; D011339:Probenecid; D010400:Penicillin G; C008472:N-methylnicotinamide