Cytotoxic function of a cloned helper T cell line.
The cytotoxic function of a well-characterized helper T hybridoma was investigated utilizing 2,4,6-trinitrophenyl (Tnp) specific B cells. The T hybridoma which is ovalbumin (Ova) specific recognizes the Ova synthetic peptide 323-339 Tyr. A number of experiments using several different antigens, Ova, Tnp-Ova and 323-339 Tyr clearly demonstrated that the cytotoxic function of the T hybridoma is strictly correlated with antigen presentation.
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D001667:Binding, Competitive; D002999:Clone Cells / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006825:Hybridomas / Q000276:immunology; D007518:Isoantibodies / Q000276:immunology; D008211:Lymphocyte Cooperation; D010047:Ovalbumin / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D007518:Isoantibodies; D010047:Ovalbumin