Local hemostasis in subarachnoid hemorrhage.
Fibrinopeptide A (FPA), platelet-secreted protein, platelet factor 4 and beta-thromboglobulin were determined in the cerebrospinal fluid of patients who had suffered from subarachnoid hemorrhage and were treated with 6 g tranexamic acid or 4 million KIU aprotinin to prevent rebleeding. Platelet-secreted proteins and FPA were cleared from the cerebrospinal fluid within 3 days after bleeding. Their vasoactive and thrombotic capability is limited to the initiation period of vasospasm that usually comes to clinical observation 3-8 days after bleeding. Increased thrombotic activity of the cerebrospinal fluid, as reflected by high levels of FPA and platelet-secreted protein, seemed to promote the occurrence of neurological deficits.
D005340:Fibrinogen / Q000134:cerebrospinal fluid*; D005344:Fibrinopeptide A / Q000134:cerebrospinal fluid*; D006801:Humans; D002546:Ischemic Attack, Transient / Q000209:etiology; D010978:Platelet Factor 4 / Q000032:analysis; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid* / Q000150:complications / Q000188:drug therapy; D014148:Tranexamic Acid / Q000627:therapeutic use; D001620:beta-Thromboglobulin / Q000134:cerebrospinal fluid*
D001620:beta-Thromboglobulin; D005344:Fibrinopeptide A; D010978:Platelet Factor 4; D014148:Tranexamic Acid; D005340:Fibrinogen