Endurance training effects on striatal D2 dopamine receptor binding and striatal dopamine metabolite levels.
We have previously shown that endurance training is associated with higher binding of [3H]spiperone to striatal D2 dopamine (DA) receptors of presenescent (21 months old) rats. In the present study we investigated the effects of 6 months of endurance training of young adults on the relationship between steady-state levels of DA and its metabolites in striatum and the affinity and density of striatal D2 DA receptors. The extent of training was confirmed by evaluating the maximal oxygen consumption (VO2 max) in the subjects. D2 DA binding was significantly increased at each of 3 [3H]spiperone concentrations in the young runners. A 'synaptic coupling ratio' calculated as the specific DA binding/DOPAC concentration was significantly increased in runners for the 0.1 and 0.4 nM radioligand concentrations. Across experimental groups levels of DA were highly and positively correlated with specific DA binding at the 0.1, 0.2 and 0.4 nM [3H]spiperone concentrations. Together, these results suggest that exercise can alter the number of DA binding sites and the metabolism of DA in young adult animals.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism*; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010648:Phenylacetates / Q000378:metabolism*; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D017448:Receptors, Dopamine D2; D013134:Spiperone / Q000378:metabolism
D010648:Phenylacetates; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D015102:3,4-Dihydroxyphenylacetic Acid; D013134:Spiperone; D006719:Homovanillic Acid