Catecholamine, dopamine-beta-hydroxylase and atrial natriuretic factor content in separate heart chambers of cardiomyopathic hamsters.
Since previous investigations have suggested a relationship between atrial natriuretic factor (ANF) and dopamine-beta-hydroxylation, cardiomyopathic hamsters were studied for atrial and ventricular catecholamine (CA) and dopamine-beta-hydroxylase (D beta H) content as correlates to a parallel finding of markedly decreased atrial but increased ventricular ANF concentrations in these animals. It was noted that, with progressive cardiomyopathy, the reduced tissue norepinephrine (NE) content paralleled the declining D beta H activity in the atria. In the ventricles, however, the progressively-decreasing NE content was associated with an increase of D beta H. These data indicate that the NE depletion is mediated by different mechanisms in the ventricles and atria. They do not support a simple relationship between NE depletion and tissue D beta H activity or between the latter and tissue ANF concentrations.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000032:analysis*; D009202:Cardiomyopathies / Q000378:metabolism*; D002395:Catecholamines / Q000032:analysis*; D006224:Cricetinae; D004298:Dopamine / Q000032:analysis; D004299:Dopamine beta-Hydroxylase / Q000032:analysis*; D006325:Heart Atria / Q000378:metabolism; D006352:Heart Ventricles / Q000378:metabolism; D008647:Mesocricetus; D009638:Norepinephrine / Q000032:analysis
D002395:Catecholamines; D009320:Atrial Natriuretic Factor; D004299:Dopamine beta-Hydroxylase; D004298:Dopamine; D009638:Norepinephrine