Effects of the dopamine D-2 receptor agonist, LY 171555, on radial arm maze performance in rats.
Rats trained to run through an 8-arm radial maze for food reinforcement were injected with a broad range of doses of the dopamine D-2 receptor agonist, LY 171555. Deficits were detected by the choice measures of entries to repeat and arms entered in the first eight choices. There was a dose-related increase in latency to finish the maze even though there was no significant increase in the number of choices needed to finish the maze.
D000818:Animals; D003071:Cognition / Q000187:drug effects; D004873:Ergolines / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D008297:Male; D019257:Quinpirole; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D017448:Receptors, Dopamine D2
D004873:Ergolines; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D019257:Quinpirole