[Control by major histocompatibility complex genes of macrophage interaction with thymocytes during induction of T-effectors of graft vs host reaction. I. Genetic control on the cellular level].
H-2 complex control of interaction between macrophages and thymocytes during induction of T-cell effectors GVH was studied. Intensity of the local GVH reaction was evaluated by the index of the lymph nodes enlargement. Genes of the H-2 system control interaction of macrophages with thymocytes during the formation of T-cell effectors GVH. H-2K subregion genes identity of interacting cells was necessary and sufficient for the effective induction of T-effectors GVH. I and D region differences did not affect the formation of T-cells inducing GVH.
D000818:Animals; D005802:Genes, MHC Class II; D006087:Graft vs Host Reaction; D006183:H-2 Antigens / Q000235:genetics* / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology; D007111:Immunity, Cellular; D008211:Lymphocyte Cooperation; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II
Kontrol' genami glavnogo kompleksa gistosovmestimosti vzaimodeĭstviiamakrofagov s timotsitami pri induktsii T-éffektorov reaktsii transplantat protiv khoziaina (RTPKh). Soobshchenie I. Geneticheskiĭ kontrol' na kletochnom urovne.