Cutaneous vascular sensitivity to lower aliphatic alcohols and aldehydes in Orientals.
An ethnic predisposition to ethanol-provoked flushing among diverse Mongoloid populations may be the consequence of a delayed oxidation and accumulation of acetaldehyde. Orientals who flush after oral alcohol are more likely to have cutaneous erythema after topical ethanol or propanol, and the cutaneous vascular reaction to primary alcohols is actually provoked by the corresponding aldehyde. The cutaneous reaction to primary alcohols can be totally blocked by pretreatment with 4-methylpyrazole, a potent inhibitor of alcohol dehydrogenase.
D000433:1-Propanol / Q000494:pharmacology; D000079:Acetaldehyde / Q000494:pharmacology; D000438:Alcohols / Q000494:pharmacology*; D000447:Aldehydes / Q000494:pharmacology*; D044466:Asian People; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D005483:Flushing / Q000209:etiology*; D005542:Forearm / Q000098:blood supply; D006801:Humans; D008297:Male; D010328:Patch Tests; D012039:Regional Blood Flow / Q000187:drug effects; D012212:Rheology; D012867:Skin / Q000098:blood supply; D014666:Vasomotor System / Q000187:drug effects
D000438:Alcohols; D000447:Aldehydes; D000431:Ethanol; D000433:1-Propanol; D000079:Acetaldehyde