The role of monocyte lymphocyte function-associated antigen 1 (LFA-1) in accessory cell function.
Monoclonal antibodies directed against the common beta subunit shared by lymphocyte function-associated antigen-1 (LFA-1), CR3 and p150,95 or the alpha subunit of LFA-1, inhibited the T lymphocyte proliferative response to tetanus toxoid, pokeweed mitogen-1 and OKT3 but had little or no effect on the response to the leukoagglutinating lectins pokeweed mitogen-2 and phytohemagglutinin. The LFA-1 molecule was shown to participate in the adhesive interaction between monocytes and T lymphocytes that was required for the initiation of an immune response. Both monocyte and T lymphocyte LFA-1 were found to contribute to this interaction. These results further define the part played by the LFA-1 molecule in the activation of T lymphocytes.
D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000276:immunology; D000918:Antibody Specificity; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000502:physiology; D000954:Antigens, Surface / Q000276:immunology*; D002448:Cell Adhesion / Q000187:drug effects; D002450:Cell Communication; D002478:Cells, Cultured; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation / Q000187:drug effects; D016169:Lymphocyte Function-Associated Antigen-1; D009000:Monocytes / Q000166:cytology / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D011951:Receptors, Complement / Q000276:immunology; D017463:Receptors, Complement 3b; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D016169:Lymphocyte Function-Associated Antigen-1; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D011951:Receptors, Complement; D017463:Receptors, Complement 3b