Chemical cholecystitis after intrahepatic chemotherapy. The case for prophylactic cholecystectomy during pump placement.
Recent repopularization of intrahepatic infusion chemotherapy has been made possible by the development of the implantable Infusaid pump. Surgical placement of a catheter into the gastroduodenal artery with division of collaterals to the stomach, duodenum, and pancreas has reduced the incidence of gastroduodenal ulceration and pancreatitis. The risk of chemical cholecystitis similarly demands prevention. Anatomically, the cystic artery is a branch of the right hepatic artery in over 95 percent of patients. As a result, even a normal gallbladder is subjected to high-dose chemotherapy with the risk of development of drug-induced cholecystitis. In our first six patients undergoing pump implantation who had normal appearing gallbladders at the time of surgery, two developed symptomatic cholecystitis, necessitating cholecystectomy after receiving intrahepatic chemotherapy. As a result, we recommend elective cholecystectomy at the time of arterial catheterization for intrahepatic chemotherapy.
D000328:Adult; D002763:Cholecystectomy; D002764:Cholecystitis / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D003110:Colonic Neoplasms / Q000188:drug therapy*; D005260:Female; D005467:Floxuridine / Q000009:adverse effects*; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D009607:Nitrosourea Compounds / Q000009:adverse effects*; D012673:Semustine / Q000009:adverse effects*
D009607:Nitrosourea Compounds; D005467:Floxuridine; D012673:Semustine; D005472:Fluorouracil