title: The effectiveness of oral midazolam as a hypnotic compared with lorazepam.
abstract: A double-blind closed sequential scheme study was carried out in 82 patients with insomnia to compare the hypnotic effectiveness of 15 mg midazolam and 1 mg lorazepam. Pairs of randomized patients were treated on one and the same night with midazolam or lorazepam, respectively. Eight parameters were recorded for each member of the pair. The time taken to fall asleep, the duration of sleep and the overall assessment of response showed that midazolam was significantly superior to lorazepam: the number of awakenings and evaluation by the patient verged on statistical significance. Both drugs were equal for the quality of sleep, dreams and the patient's condition on awakening. No side-effects were observed in any of the patients.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D001569:Benzodiazepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006207:Half-Life; D006801:Humans; D008140:Lorazepam / Q000627:therapeutic use*; D008297:Male; D008874:Midazolam; D008875:Middle Aged; D011897:Random Allocation; D012890:Sleep / Q000187:drug effects*; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*
chemical_list: D001569:Benzodiazepines; D008140:Lorazepam; D008874:Midazolam