Cellular and humoral immune responses in experimental aspergillosis in mice.
Invasive aspergillosis was established in a naive murine model. Both humoral and cellular aspects of the immunological mechanism responded to invasion. Circulating immune complexes containing IgG in the infected group of animals were detected by both the C1q and conglutinin solid phase assays. Attempts to identify these complexes as Aspergillus antigen-specific complexes were unsuccessful. Cellular responses, as measured by blastogenic activity and inhibition of migration of sensitized cells were significantly elevated in the infected group.
D000818:Animals; D000908:Antibodies, Fungal / Q000096:biosynthesis*; D000936:Antigen-Antibody Complex / Q000032:analysis*; D001228:Aspergillosis / Q000276:immunology*; D001232:Aspergillus fumigatus / Q000276:immunology*; D002464:Cell Migration Inhibition; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007700:Kinetics; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D013047:Specific Pathogen-Free Organisms
D000908:Antibodies, Fungal; D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G