Perturbation of the immune network in herpes gestationis.
We have studied the development of anti-idiotypic antibodies to HLA and of autoantibodies reacting with alloactivated T lymphoblasts in a woman with herpes gestationis (HG). This primigravida developed an elevated titer of anti-HLA antibodies, (Ab1), in association with a low titer and late appearance of anti-anti-HLA antibodies (Ab2). At delivery she developed only minimal levels of antibodies reacting with autologous T lymphoblasts (T1), sensitized against the immunizing HLA antigens of the child. Her serum reacted, however, with T lymphoblasts, primed in AMLC against autologous T blasts alloactivated in vitro against her husband (T2). Because healthy gravidae do not show such antibodies, it appears that they are peculiar to and may represent a perturbation of the idiotypic network in regard to the immune
D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007959:Lymphocyte Culture Test, Mixed; D008285:Major Histocompatibility Complex; D006559:Pemphigoid Gestationis / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D001323:Autoantibodies; D006680:HLA Antigens; D007140:Immunoglobulin Fab Fragments; D007130:Immunoglobulin Idiotypes