[Evaluation of malnutrition and immunity in alcoholic liver diseases].
Disorders of immunity and nutritional status are known to be present in alcohol-induced diseases of the liver, but their significance is still debated. Nutrition and immunity were evaluated at different stages of the disease in 58 alcoholic patients with steatosis (n = 20), alcoholic hepatitis (n = 14) or cirrhosis (n = 24). Most of the anthropometric data and biochemical values relating to nutrition were altered to the same degree in these 3 groups. Only patients with cirrhosis had significantly lower blood albumin and zinc levels (P less than 0.01). Humoral immunity was altered in cirrhosis only and cellular immunity in all 3 liver diseases. There was no correlation between immunity and nutrition (except for blood zinc and E rosettes; P less than 0.01) or between these and alcohol consumption. Like several nutritional parameters, blood lymphocyte values correlated negatively with a liver disease severity index. It is concluded that disorders of nutrition and immunity are broadly comparable in alcohol-induced liver diseases; there is no direct statistical correlation between these disorders which seem to be independent of the type of liver disease.
D000328:Adult; D000368:Aged; D000917:Antibody Formation; D005234:Fatty Liver / Q000150:complications; D005260:Female; D006519:Hepatitis, Alcoholic / Q000150:complications; D006801:Humans; D007154:Immune System Diseases / Q000175:diagnosis* / Q000209:etiology; D007111:Immunity, Cellular; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications; D008108:Liver Diseases, Alcoholic / Q000150:complications* / Q000276:immunology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D009748:Nutrition Disorders / Q000175:diagnosis* / Q000209:etiology; D015032:Zinc / Q000097:blood
D015032:Zinc
Evaluation de la dénutrition et de l'immunité au cours des maladies alcooliques du foie.