A new semisynthetic ergot peptide alkaloid: DCN 203-922.
We report the synthesis, stereochemistry and preliminary pharmacological evaluation of DCN 203-922, a novel ergot alkaloid of the cyclol type, which contains in its peptide moiety the uncommon amino acid L-allo-isoleucine.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D003460:Crystallization; D004876:Ergot Alkaloids / Q000138:chemical synthesis* / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects; D008968:Molecular Conformation; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D017448:Receptors, Dopamine D2; D012895:Sleep, REM / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects
D004876:Ergot Alkaloids; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; C053770:DCN 203-922