title: Conversion of rat muscle fiber types. A time course study.
abstract: Rats were used in this study to determine the time course of conversion of muscle fiber types. The right or left gastrocnemius muscle was removed thereby causing an overload on the ipsilateral soleus and plantaris muscles. The contralateral limb served as a control. The type II to type I fiber conversion was followed histochemically in the soleus and plantaris muscles for one to six weeks following surgery. Muscle sections were stained for myofibrillar actomyosin ATPase and NADH tetrazolium reductase. The type I population in the soleus muscle was 99.3% six weeks after synergist removal. The plantaris muscle underwent a two fold increase in the percentage of type I fibers after six weeks. Transitional fibers were prominent in the plantaris muscle and reached their peak at 4% (P less than 0.05) of the total population, four weeks after surgery.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D005260:Female; D008297:Male; D009132:Muscles / Q000166:cytology* / Q000201:enzymology; D009246:NADH Tetrazolium Reductase / Q000378:metabolism; D051381:Rats; D013997:Time Factors
chemical_list: D009246:NADH Tetrazolium Reductase; D000251:Adenosine Triphosphatases