In vitro effects of glucidamine on adrenergic stimulated lipolysis and on lipoprotein lipase activity in human adipose tissue.
Glucidamine, a purified glycoprotein-mucopolysaccharide complex displays dose-dependent lipolytic effect on human adipose tissue in vitro. On adipose tissue lipoprotein lipase activity glucidamine exhibits an heparin-like effect in eluting the enzyme from the tissue stores to the medium of incubation. No activating effects of glucidamine on lipoprotein lipase eluted from human adipose tissue was observed.
D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008066:Lipolysis / Q000187:drug effects*; D008071:Lipoprotein Lipase / Q000032:analysis*; D011509:Proteoglycans / Q000494:pharmacology*; D013566:Sympathomimetics / Q000494:pharmacology
D006025:Glycosaminoglycans; D011509:Proteoglycans; D013566:Sympathomimetics; C050875:glucidamine; D008071:Lipoprotein Lipase