Atrial natriuretic factor inhibits the sympathetic nervous activity in one-kidney, one-clip hypertension in the rat.
The one-kidney, one-clip model of rat hypertension was found to have an increased natriuresis following chronic infusion of atrial natriuretic factor (ANF). We have now found that this natriuretic effect of ANF is associated with a suppression of the initially elevated urinary excretion of norepinephrine and epinephrine and increase of the excretion of the main dopamine metabolite-dihydroxyphenylacetic acid as well as of the urinary dopamine to norepinephrine ratio. These data are compatible with the hypothesis that ANF suppresses the increased sympathetic activity in this model of hypertension and this action combined with opposite changes of dopamine may contribute to the natriuretic effect of ANF.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D003404:Creatinine / Q000378:metabolism; D004231:Diuresis / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D006978:Hypertension, Renovascular / Q000503:physiopathology*; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000503:physiopathology
C472610:atrial natriuretic peptide, rat; D009320:Atrial Natriuretic Factor; D003404:Creatinine; D004298:Dopamine; D009638:Norepinephrine