[Comparative studies of the effect of a cardioselective and a noncardioselective beta-blocker on peripheral circulation in patients with arterial occlusive disease].
The effect of celiprolol at a daily dosage of 300 mg (19 patients) was compared with that of propranolol at a daily dosage of 120 mg (14 patients) on peripheral blood flow of the calf and foot in a randomized double-blind trial. Altogether 33 patients (47 extremities) suffering from arterial occlusive disease (stage II according to Fontaine) and hypertension, were treated for 25 days. Blood flow was measured by strain-gauge plethysmography. Celiprolol led to a small, insignificant increase in resting blood flow of the muscle. Propranolol produced a small decrease in resting blood flow of the muscle, and a significant fall in resting blood flow of the skin of the foot. At the completion of treatment with celiprolol there was a small increase in the initial value of reactive hyperaemia of the calf. Propranolol led to a decrease in the initial, and in the maximum values of reactive hyperaemia of the calf and foot. Celiprolol and propranolol led to a comparable decrease in resting blood pressure.
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D017272:Celiprolol; D005528:Foot / Q000098:blood supply; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply*; D008875:Middle Aged; D010991:Plethysmography; D011412:Propanolamines / Q000009:adverse effects* / Q000627:therapeutic use; D011433:Propranolol / Q000009:adverse effects* / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply
D011412:Propanolamines; D011433:Propranolol; D017272:Celiprolol
Vergleichende Untersuchungen über die Wirkung eines kardioselektiven und eines nichtkardioselektiven Betablockers auf die periphere Durchblutung von Patienten mit arterieller Verschlusskrankheit.