title: Effect of a selective thromboxane synthase inhibitor on arterial graft patency and platelet deposition in dogs.
abstract: This study examined the effect of selective thromboxane synthase inhibition and nonselective cyclooxygenase inhibition on vascular graft patency and indium 111-labeled platelet deposition in 35 mongrel dogs undergoing carotid artery replacement with 4 mm X 4 cm polytetrafluoroethylene (PTFE) (one side) and Dacron (opposite side) end-to-end grafts. Aspirin-dipyridamole therapy improved one-week graft patency, from 46% in untreated dogs to 93% in treated dogs. Thromboxane synthase inhibition (U-63557A) improved graft patency in these dogs to 81%. Both drug treatments reduced platelet deposition on Dacron and PTFE grafts by 48% to 68% compared with control dogs. Dacron grafts accumulated significantly more platelets than PTFE grafts but had comparable patency rates. Low-dose aspirin therapy had no significant effect on either graft patency or platelet deposition. All treatment groups showed a 60% to 76% reduction in serum thromboxane B2, but only thromboxane synthase inhibitor treatment increased plasma 6-keto-prostaglandin F1 alpha by 100%. Selective thromboxane synthase inhibition improved small-caliber prosthetic graft patency to the same extent as did conventional cyclooxygenase inhibition in this preliminary study.
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000284:Administration, Oral; D000818:Animals; D001158:Arteries / Q000601:surgery*; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology; D001572:Benzofurans / Q000008:administration & dosage / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D001807:Blood Vessel Prosthesis / Q000009:adverse effects; D002339:Carotid Arteries / Q000601:surgery; D004176:Dipyridamole / Q000008:administration & dosage / Q000494:pharmacology; D004285:Dogs; D005260:Female; D007204:Indium; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D011868:Radioisotopes; D011897:Random Allocation; D013929:Thromboxane B2 / Q000097:blood; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
chemical_list: D001572:Benzofurans; D011093:Polyethylene Terephthalates; D011868:Radioisotopes; D007204:Indium; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D004176:Dipyridamole; D011138:Polytetrafluoroethylene; D013930:Thromboxane-A Synthase; C039936:furegrelate; D001241:Aspirin