Regulation of IgE synthesis by macrophages expressing FcE-receptors: role of interleukin 1.
Triggering rat macrophages with IgE complexes induced the production of interleukin 1-like activity (IL-1). The signal is delivered through the macrophage FcE receptor since stimulating macrophages with IgE bound to spleen cells (to avoid endocytosis) or with an anti-FcE receptor antibody linked to nonphagocytizable cells also led to IL-1 production. The molecular weight of IL-1 produced after IgE triggering is in the same range (30 kD) as previously described for rat IL-1. A positive feed-back effect of IL-1 on IgE response was suggested, as purified IL-1 was able to enhance IgE synthesis in vitro by lymphocytes from immunized animals.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007375:Interleukin-1 / Q000096:biosynthesis / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains; D011961:Receptors, Fc / Q000032:analysis* / Q000276:immunology; D017455:Receptors, IgE
D000936:Antigen-Antibody Complex; D007375:Interleukin-1; D011961:Receptors, Fc; D017455:Receptors, IgE; D007073:Immunoglobulin E