title: In vitro activity of A-56268 (TE-031), a new macrolide antibiotic, compared with that of erythromycin and other antimicrobial agents.
abstract: A-56268 is a new macrolide antibiotic that resembles erythromycin in its spectrum of activity. A-56268 and erythromycin had identical activities against Streptococcus pyogenes, group B, C, and G streptococci, and viridans group streptococci. Erythromycin and A-56268 had similar activities against Staphylococcus aureus, coagulase-negative staphylococci, and group D enterococci. Like erythromycin, A-56268 was ineffective in inhibiting oxacillin-resistant S. aureus, oxacillin-resistant, coagulase-negative staphylococci, and penicillin-resistant viridans group streptococci. Haemophilus influenzae, Neisseria gonorrhoeae, and Legionella spp. were inhibited by A-56268 at concentrations similar to those of erythromycin.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D017291:Clarithromycin; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin; D017291:Clarithromycin