LY165163 and 8-OH-DPAT have agonist effects on a serotonin responsive muscle of Aplysia.
Serotonin enhances acetylcholine-elicited contractions of buccal muscle E1 of Aplysia. To characterize the serotonin receptor, actions of ligands of specific serotonin receptor subtypes were examined. Ketanserin, an antagonist at 5-HT2 receptors, had little effect. Two 5-HT1A ligands, LY165163 and 8-OH-DPAT, mimicked the effect of serotonin, although with slower kinetics. This suggests that the peripheral serotonin receptor in Aplysia more closely resembles 5-HT1 than 5-HT2 receptors.
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001048:Aplysia / Q000502:physiology*; D066298:In Vitro Techniques; D007650:Ketanserin / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009281:Naphthalenes / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D009281:Naphthalenes; D010879:Piperazines; D013764:Tetrahydronaphthalenes; D012701:Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; C044643:LY 165163; D007650:Ketanserin; D000109:Acetylcholine