title: Different abilities of two distinct Fc gamma receptors on guinea pig polymorphonuclear leukocytes to trigger the arachidonic acid metabolic cascade.
abstract: The nature of signals transmitted by two Fc gamma receptors (Fc gamma 2R for IgG2 and Fc gamma 1/gamma 2R for both IgG2 and IgG1) on guinea pig polymorphonuclear leukocytes was investigated. The specific binding of hen ovalbumin (OA)-complexed IgG1 antibody to Fc gamma 1/gamma 2R did not seem to trigger the release of [3H]arachidonic acid from the cells prelabeled with [3H]arachidonic acid. In contrast, marked release occurred on the binding of OA-complexed IgG2 antibody to the cells. This reaction was not inhibited, but rather enhanced, by the Fab' of a monoclonal antibody to Fc gamma 1/gamma 2R. Therefore, a signal for the activation of the arachidonic acid metabolic cascade was found to be transmitted by Fc gamma 2R, but scarcely by Fc gamma 1/gamma 2R.
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000378:metabolism; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D006168:Guinea Pigs; D007074:Immunoglobulin G / Q000378:metabolism*; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism*; D011961:Receptors, Fc / Q000145:classification / Q000276:immunology / Q000502:physiology*; D017452:Receptors, IgG
chemical_list: D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D001095:Arachidonic Acids; D007074:Immunoglobulin G; D011961:Receptors, Fc; D017452:Receptors, IgG; D016718:Arachidonic Acid