The effects of suppressive activities mediated by cells on the protection of fetus against maternal immune rejection.
Using both mixed lymphocyte reaction (MLR) and graft-versus-host reaction (GVHR) assays, investigations have been made on 60 multiparous mice of late pregnancy, derived from C57BL mating with SWI as well as C57BL mating with BGI. The results demonstrate the presence of suppressor cells both in uterus-draining-lymphnodes (DLN) and in spleen of allogeneic pregnant mice. The suppressive immune regulatory activity mediated by these cells might play an important role in the successful maintenance of fetus allograft. The possible mechanisms about the inducing of the changes in lymphocyte subpopulation are also studied in this paper.
D000818:Animals; D005260:Female; D005333:Fetus / Q000276:immunology*; D006084:Graft Rejection; D006087:Graft vs Host Reaction; D007111:Immunity, Cellular; D008198:Lymph Nodes / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D011270:Pregnancy, Animal; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*