Reference values for peripheral blood lymphocytes from Aotus lemurinus ssp. griseimembra (owl monkey).
The reactivities of several monoclonal antibodies that define human lymphocyte cell-surface antigens have been tested with peripheral blood lymphocytes of Aotus lemurinus ssp. griseimembra. Based on reactivity patterns in humans, reactive MoAb were identified that mark pan-T, helper/inducer, suppressor/cytotoxic, pan-B, and natural killer cells. Reference values of these subsets in Aotus are presented. These MoAb should provide a useful tool for further phenotypic and functional dissection of the immune system in this simian model of human disease.
D000818:Animals; D000911:Antibodies, Monoclonal; D001029:Aotus trivirgatus / Q000097:blood / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D002427:Cebidae / Q000276:immunology*; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D007694:Killer Cells, Natural / Q000276:immunology; D007958:Leukocyte Count / Q000662:veterinary; D008214:Lymphocytes / Q000145:classification* / Q000276:immunology; D012016:Reference Values; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal