Comparison of ketanserin and pindolol in hypertension.
The antihypertensive effects of ketanserin (40 mg twice daily) and pindolol (5 mg twice daily) as monotherapy were compared in a crossover, double-blind trial in 17 patients with essential hypertension. Both ketanserin and pindolol decreased supine systolic and diastolic blood pressure significantly (P less than 0.01 for systolic and P less than 0.001 for diastolic) when evaluated at the end of the 2-month treatment periods. There was no significant difference between the two drugs. No significant changes in heart rate were observed on either drug. Both drugs were well tolerated.
D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007650:Ketanserin; D008297:Male; D008875:Middle Aged; D010869:Pindolol / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*; D011897:Random Allocation
D010880:Piperidines; D007650:Ketanserin; D010869:Pindolol