Dehydration-induced changes in the secretion of atrial natriuretic factor in Brattleboro rats: effect of water-drinking.
The secretion of atrial natriuretic factor (ANF) was measured in Brattleboro rats (DI) subjected to 20-h dehydration and in normal Long-Evans rats (LE) subjected to 72-h dehydration and 7 times within the hour following voluntary rehydration by drinking water. In these rats, water deprivation caused a large, significant drop in plasma immunoreactive ANF (IR-ANF). Drinking water did not restore plasma IR-ANF values within one hour, even when indirect indices of intravascular volume such as serum osmolality, sodium and hematocrit returned to normal. The dehydration-induced decrease in plasma IR-ANF and its very low secretion after restoring drinking may be essential for the homeostasis of water conservation in both DI and LE rats.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D003681:Dehydration / Q000378:metabolism*; D004326:Drinking; D006720:Homozygote; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010953:Plasma Volume; D051381:Rats; D011910:Rats, Brattleboro
D009320:Atrial Natriuretic Factor