title: Identification of new B27 subtypes (B27C and B27D) prevalent in oriental populations.
abstract: With the aid of alloreactive cytotoxic T lymphocytes, three subtypes of HLA-B27 can be defined: B27W, B27K, and B27C (non-B27W and non-B27K). The B27C subtype can be distinguished by 1D-IEF, is not recognized by B27W- or B27K-restricted influenza-A-specific cytotoxic T lymphocytes, and is prevalent in Oriental populations. Preliminary data indicate that the various B27 subtypes (W, K, C) are in different linkage disequilibria with HLA-C antigens. A fourth subtype of B27 (non-B27W and non-B27K), designated as B27D, was detected by 1D-IEF. (See accompanying paper by Neefjes et al.) The finding of four B27 subtypes indicates that the serologically defined B27 antigen comprises a family of various, strongly cross-reactive class-I molecules.
mesh_terms: D044466:Asian People; D002681:China / Q000208:ethnology; D003429:Cross Reactions; D003430:Cross-Sectional Studies; D006680:HLA Antigens / Q000032:analysis / Q000145:classification* / Q000235:genetics; D015796:HLA-B27 Antigen; D015236:HLA-C Antigens; D006801:Humans; D007214:Indonesia / Q000208:ethnology; D007525:Isoelectric Focusing / Q000379:methods; D007564:Japan / Q000208:ethnology; D007959:Lymphocyte Culture Test, Mixed / Q000379:methods; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D044465:White People
chemical_list: D006680:HLA Antigens; D015796:HLA-B27 Antigen; D015236:HLA-C Antigens