Laser Doppler flow-meter assessment of iontophoretically applied norepinephrine on human finger skin circulation.
A miniaturized technique to administer vasoactive substances iontophoretically into the human finger skin and to continuously assess the resulting reaction of the vessels is described. Cutaneous blood flow is measured with a laser Doppler flow-meter. The technique has been used in 9 healthy volunteers with norepinephrine as test substance. The described method is a convenient way to evaluate the effects of transdermally applied vasoactive substances in a semiquantitative way without risking central effects of the substance to influence the registered blood flow.
D005385:Fingers; D006801:Humans; D007478:Iontophoresis; D007834:Lasers; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D012212:Rheology; D012867:Skin / Q000098:blood supply*
D009638:Norepinephrine