title: Partial defect in hepatic glutathione S-transferase activity in a case of Rotor's syndrome.
abstract: In a 17 year-old male patient with Rotor's syndrome, hepatic glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene reduced to about 0.2% of the mean activity of patients with other diseases. The activities toward sulfobromophthalein and 1,2-dichloro-4-nitrobenzene were low (44% and 47%, respectively, of those controls), but basically present. Bilirubin UDP-glucuronyltransferase activity in this Rotor's syndrome case was in the normal range.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002769:Cholelithiasis / Q000201:enzymology; D004137:Dinitrochlorobenzene; D005964:Glucosyltransferases / Q000378:metabolism; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D006933:Hyperbilirubinemia, Hereditary / Q000201:enzymology* / Q000235:genetics; D007223:Infant; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D009578:Nitrobenzenes; D013379:Substrate Specificity; D013448:Sulfobromophthalein
chemical_list: D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes; D013448:Sulfobromophthalein; C028328:1,2-dichloro-4-nitrobenzene; D005964:Glucosyltransferases; C035814:bilirubin UDP-glucosyltransferase; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase