Regulation of liver corticoid metabolism during early postnatal life: effects of surgical stress.
Corticosterone metabolism by liver slices was investigated in suckling (10-day-old), weanling (21-day-old) and adult male rats. During the suckling period adrenalectomy as well as sham adrenalectomy increase the rate of steroid A ring reduction and also the rate of steroid side chain degradation by 20-40%. In older animals such changes were not detected. The results support an earlier assumption that liver steroid metabolism is regulated in an age specific manner.
D000302:Adrenal Cortex / Q000502:physiology*; D000315:Adrenalectomy; D000367:Age Factors; D000818:Animals; D000833:Animals, Suckling; D003345:Corticosterone / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000378:metabolism; D013514:Surgical Procedures, Operative; D014886:Weaning
D003345:Corticosterone