[Side effects of hormonal contraception. Experiences with 1,702 patients and 17,228 cycles].
During 25 years 1,702 women with 17,228 cycles under oral contraceptive were observed. This report covers 1,021 women with 11,648 cycles and the frequency of side-effects. The acceptability of OC's is more and more dominated by the side-effects. All subjective symptoms were asked for and not--as usually done--just noted when the woman complained spontaneously. For objective results the bleeding calendar was controlled for amenorrhea, spottings and break-through bleedings. Lowering the ethinylestradiol dose below 50 micrograms (with monophasic OCs, micropills) resulted in a worse cycle control as far as bleeding and silent menstruation were concerned. The genuine normophasic method showed generally a far better cycle control. Combining this method with a new gestagen (Desogestrel) resulted a still better cycle control, especially with amenorrhea. The events of nervosity, gastrointestinal disturbances, changes of libido and fatigue were also less frequent with this OC (Ovidol-Oviol).
D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D017135:Desogestrel; D004305:Dose-Response Relationship, Drug; D004997:Ethinyl Estradiol / Q000009:adverse effects; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects*; D009652:Norpregnenes / Q000009:adverse effects
D003278:Contraceptives, Oral, Hormonal; D009652:Norpregnenes; D004997:Ethinyl Estradiol; D017135:Desogestrel
Nebenerscheinungen hormoneller Kontrazeption Erfahrungen bei 1702 Patientinnen und 17,228 Zyklen.