title: [Disorders of the receptor system in regulating extracellular fluid volume in patients with rheumatic heart defects].
abstract: The production and urinary excretion of the natriuretic factor and sodium output decreased in patients with rheumatic heart defects as left-atrial dilatation progressed and signs of circulatory insufficiency grew more apparent. It is suggested that prolonged left-atrial dilatation is associated with a fall of volume receptor sensitivity and insufficient left-atrial production of substances activating the natriuretic factor involved in abnormal water-salt metabolism in these patients.
mesh_terms: D000328:Adult; D000818:Animals; D006332:Cardiomegaly / Q000209:etiology; D005110:Extracellular Space / Q000378:metabolism*; D005260:Female; D006325:Heart Atria / Q000503:physiopathology; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009318:Natriuresis; D045283:Natriuretic Agents / Q000172:deficiency / Q000502:physiology*; D051381:Rats; D012214:Rheumatic Heart Disease / Q000503:physiopathology*; D011984:Sensory Receptor Cells / Q000502:physiology*
chemical_list: D045283:Natriuretic Agents
vernacular_title: Narusheniia retseptornogo zvena reguliatsii ob'ema vnekletochnoĭ zhidkosti u bol'nykh revmaticheskimi porokami serdtsa.