Spectroscopic, biological, and antitumor studies on N-ethyl- and N-propylimidazole platinum(II) complexes.
Platinum(II) halide complexes with N-ethylimidazole (N-EtIm) and N-propylimidazole (N-PropIm) of the Pt(L)2X2 and Pt(L)4X2 types (X = Cl, Br, I) were prepared and characterized by far infrared spectra, electronic spectra, and conductivity measurements. The inhibitorial activity of some complexes on the Ca,Mg-dependent ATPase and the antitumor studies of the Pt(L)4Cl2 derivatives have been investigated. Pt complexes are not inhibitory active in comparison to the same Pd complexes (if c = 10(-4) M). The LD50 in physiological solution for [Pt(N-EtIm)4]Cl2 X 2H2O and [Pt(N-PropIm)4]Cl2 are higher enough with respect to the cis platinum.
D000818:Animals; D000970:Antineoplastic Agents; D017301:Ca(2+) Mg(2+)-ATPase / Q000037:antagonists & inhibitors; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors; D005260:Female; D007093:Imidazoles / Q000627:therapeutic use / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009944:Organoplatinum Compounds / Q000627:therapeutic use / Q000633:toxicity; D013053:Spectrophotometry; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D007093:Imidazoles; D009944:Organoplatinum Compounds; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases