title: Heart atrial auriectomy reduces the diuretic and natriuretic responses to a hypertonic saline load.
abstract: Acute bilateral atrial auriectomy in anesthetized dogs reduced diuresis and natriuresis induced by both extracellular fluid volume expansion with isotonic saline and a hypertonic saline load. Since a hypertonic saline load, in contrast to isotonic saline infusion, was not accompanied by a significant increase in central venous pressure it is proposed that either increased plasma osmolality or plasma sodium concentration (or both) participate in the modulation of the atrial natriuretic mechanism.
mesh_terms: D000818:Animals; D016275:Atrial Function; D002496:Central Venous Pressure; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005110:Extracellular Space / Q000187:drug effects / Q000502:physiology; D005260:Female; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006325:Heart Atria / Q000187:drug effects; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D009994:Osmolar Concentration; D012964:Sodium / Q000097:blood; D012965:Sodium Chloride / Q000008:administration & dosage
chemical_list: D012965:Sodium Chloride; D012964:Sodium