Potentiation of hypotensive effect of debrisoquine by insulin.
A 36-year-old man who had been an insulin-dependent diabetic for 27 years developed severe postural hypotension only when taking debrisoquine and a short-acting insulin. Hourly recordings of lying and standing blood pressure after an oral dose of debrisoquine in the presence and absence of short-acting insulin confirmed an interaction between the drugs causing symptoms of postural hypotension which may be confused with hypoglycaemia.
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D003647:Debrisoquin / Q000627:therapeutic use*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy; D004357:Drug Synergism; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D007328:Insulin / Q000627:therapeutic use*; D007546:Isoquinolines / Q000627:therapeutic use*; D008297:Male
D000959:Antihypertensive Agents; D007328:Insulin; D007546:Isoquinolines; D003647:Debrisoquin