title: Methysergide-induced lower extremity arterial insufficiency.
abstract: Lower extremity arterial insufficiency, a relatively common complication of ergotamine ingestion, is a rare complication of methysergide therapy for migraine headaches. Methysergide causes one of two typical angiographic patterns: intra-abdominal extrinsic compression of the aorto-iliac vessels in patients with retroperitoneal fibrosis, or marked diffuse bilateral spasm of the superficial femoral arteries in those without retroperitoneal fibrosis. We report a patient with methysergide-induced bilateral lower extremity arterial spasm and review the relevant literature. When one of the above arteriographic patterns is recognized, methysergide ingestion should be considered as a possible etiology.
mesh_terms: D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging; D006801:Humans; D008784:Methysergide / Q000009:adverse effects*; D008875:Middle Aged; D011859:Radiography; D014652:Vascular Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging
chemical_list: D008784:Methysergide