beta-Endorphin-(1-27) inhibits the spinal beta-endorphin-induced release of Met-enkephalin.
The effect of intraventricular beta-endorphin-(1-27) on the spinal release of Met-enkephalin induced by intraventricular beta-endorphin was studied using the intrathecal superfusion technique in urethane anesthetized rats. Intraventricular injection of beta-endorphin at a dose of 15 micrograms released Met-enkephalin from the spinal cord. This release of Met-enkephalin induced by beta-endorphin was significantly reduced by beta-endorphin-(1-27), 60 micrograms, injected intraventricularly. Injection of beta-endorphin (1-27) itself did not cause any release of Met-enkephalin. The finding is in line with the previous report that beta-endorphin (1-27) inhibited the analgesia induced by beta-endorphin.
D000818:Animals; D003864:Depression, Chemical; D004723:Endorphins / Q000008:administration & dosage / Q000494:pharmacology*; D004744:Enkephalin, Methionine / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism*; D001615:beta-Endorphin
D004723:Endorphins; D010446:Peptide Fragments; D004744:Enkephalin, Methionine; D001615:beta-Endorphin; C035581:beta-endorphin (1-27)