[Demonstration of glycoprotein antigens associated with stomach tumors].
After precipitation of the glycoproteins from gastric tumor tissues by caprylic acid, immunochemical methods were applied to the research of specific gastric tumor antigens; this precipitation process by caprylic acid was less aggressive than the use of urea or proteases. The purification of a fraction associated with tumor tissue has been carried out by affinity chromatography with a specific antiserum immobilized on Sepharose. The obtained fraction contains 4 proteic antigens. One of them is common with all the gastric extracts. Neither CEA, nor alpha-foetoprotein has been detected in this fraction. The corresponding antiserum seems to show a tumor specificity, whereas tissue specificity has to be demonstrated.
D000951:Antigens, Neoplasm / Q000032:analysis*; D004591:Electrophoresis, Polyacrylamide Gel; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D007106:Immune Sera; D005779:Immunodiffusion; D008970:Molecular Weight; D013274:Stomach Neoplasms / Q000276:immunology*
D000951:Antigens, Neoplasm; D006023:Glycoproteins; D007106:Immune Sera
Mise en évidence d'antigènes glycoprotéiques associés aux tumeurs de l'estomac.