[Increase of the antigenicity of B16 melanoma cell membranes by microwave hyperthermia].
An injection of a suspension of B16 melanoma cell membranes, treated with micro-wave hyperthermia, increases the survival time of mice inoculated 26 days after with 10(7) (viability greater than 95%) of B16 melanoma. This delay (26 days) between these two injections corresponds to the moment where the synthesis of sera anticorps (IgG, IgA, IgM) is increased in "protected" mice. The earliest death of animals injected with untreated tumoral cell membranes and who received a suspension of B16 melanoma cells can be explained by an inhibition of humoral immunity system.
D000818:Animals; D000917:Antibody Formation; D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects / Q000276:immunology; D006979:Hyperthermia, Induced; D007116:Immunization, Passive; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008545:Melanoma / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008872:Microwaves
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Augmentation de l'antigénicité des membranes cellulaires du mélanome B16 avec l'hyperthermie par micro-ondes.