Cold air-induced rhinorrhea and high-dose ipratropium.
A high dose of the cholinoceptor antagonist ipratropium bromide, in the form of a nasal spray, was tested on cold air- and hot soup-induced rhinorrhea in order to determine to what extent these types of rhinorrhea are reflex-mediated hypersecretions from nasal glands. Fourteen normal volunteers were examined in a placebo-controlled study. A single dose of ipratropium bromide (400 micrograms) caused a 73% reduction of cold air-induced rhinorrhea and a 66% reduction of hot soup-induced rhinorrhea. It is concluded that a major part of the nasal discharge induced by these stimuli is reflex-mediated, and consequently may be treated by a cholinoceptor antagonist, such as ipratropium.
D000281:Administration, Intranasal; D000328:Adult; D001286:Atropine Derivatives / Q000627:therapeutic use*; D003080:Cold Temperature; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism*; D011897:Random Allocation; D012018:Reflex / Q000502:physiology
D001286:Atropine Derivatives; D009241:Ipratropium