Painful palmar and plantar erythema associated with hepatic artery infusion of 5-fluoro-2'deoxyuridine.
Painful palmar and plantar erythema is an uncommon systemic complication of chemotherapy and has been reported in association with methotrexate, cystosine arabinoside, doxorubicin, and 5-fluorouracil. The authors report a case in which the syndrome was precipitated by hepatic artery infusion of 5-FUdR. The previous recommendation that treatment of patients developing painful palmar-plantar erythema from other drugs may be successfully resumed using intrahepatic arterial infusion of FUdR must be reconsidered in light of the present report.
D004890:Erythema / Q000139:chemically induced*; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005533:Foot Dermatoses / Q000139:chemically induced*; D006229:Hand Dermatoses / Q000139:chemically induced*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy; D008875:Middle Aged
D005467:Floxuridine; C025034:doxifluridine