Effects of a new quinoline derivative, ciprofloxacin, on some professional phagocytic cell functions.
This study reports the effects of ciprofloxacin on in vitro chemotactic, phagocytic and bactericidal activity of human polymorphonuclear leukocytes, human mononuclear cells differentiated in vitro and rat peritoneal macrophages. After in vitro preincubation with different concentrations of ciprofloxacin, acridine orange vital staining for phagocytosis and killing and the Boyden chamber for chemotaxis evaluation were used. Results obtained with different cell types showed no negative effects on the different functions tested, even at concentrations ranging from about 100 micrograms/ml.
D000818:Animals; D002176:Candida albicans; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D002939:Ciprofloxacin; D004731:Endotoxins / Q000494:pharmacology; D004926:Escherichia coli; D005260:Female; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D008297:Male; D009000:Monocytes / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D010529:Peritoneal Cavity / Q000166:cytology; D010587:Phagocytosis / Q000187:drug effects*; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D004731:Endotoxins; D011804:Quinolines; D002939:Ciprofloxacin