[Venous thromboembolic disease and Klinefelter's syndrome].
Venous thromboembolic disease was rarely described in association with Klinefelter's syndrome. It is nevertheless more frequent than in a genetically normal male population (5-20 times). This abnormality is not clearly explained. We report a classical case of Klinefelter's syndrome detected by the help of a venous thromboembolic disease. The patient was of blood-group A (the relative incidence of thrombosis is raised among group-A persons as compared with group-O persons). The evaluation disclosed a high rate of beta-thromboglobulin suggesting an underlying hypercoagulability. The abnormal incidence of venous thromboembolic disease among Klinefelter patients may find a partial explanation in this way.
D000017:ABO Blood-Group System; D001780:Blood Coagulation Tests; D006801:Humans; D007713:Klinefelter Syndrome / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000097:blood / Q000150:complications; D013923:Thromboembolism / Q000097:blood / Q000150:complications*; D013924:Thrombophlebitis / Q000097:blood / Q000150:complications; D001620:beta-Thromboglobulin / Q000032:analysis
D000017:ABO Blood-Group System; D001620:beta-Thromboglobulin
Maladie veineuse thromboembolique et syndrome de Klinefelter.