Study on the mechanism of the long-lasting antagonistic effect of caerulein on amphetamine-induced hyperactivity in rats.
The long-lasting antagonistic effect of caerulein (CLN) on amphetamine (AMP) hyperactivity was abolished in rats following partial 6-OHDA lesions of the nucleus accumbens (NA) or dopamine (DA) A10 area. CLN showed the long-term antagonistic effect on AMP hyperactivity in rats following complete 6-OHDA lesions of the DA A9 area. Neonatal monosodium L-glutamate-treated rats did not show the CLN effect. These results suggest that opiate receptors presynaptically located on DA neurons in the NA and some modulatory changes in the beta-endorphin system in the arcuate nucleus may play an important role in producing the CLN effect.
D000661:Amphetamine / Q000037:antagonists & inhibitors*; D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000502:physiology; D002108:Ceruletide / Q000494:pharmacology*; D004723:Endorphins / Q000378:metabolism; D006220:Haloperidol / Q000494:pharmacology; D006892:Hydroxydopamines / Q000633:toxicity; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009714:Nucleus Accumbens / Q000502:physiology; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D012970:Sodium Glutamate / Q000633:toxicity; D001615:beta-Endorphin
D004723:Endorphins; D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D001615:beta-Endorphin; D002108:Ceruletide; D016627:Oxidopamine; D000661:Amphetamine; D006220:Haloperidol; D012970:Sodium Glutamate