title: Antistaphylococcal activity of teicoplanin in association with other antibiotics.
abstract: The in vitro activity of antibiotic combination of teicoplanin and gentamicin (or netilmicin) and teicoplanin and cephalotin on Staphylococcus aureus was evaluated using the checkerboard method and time-kill curves. With few exceptions neither antagonism nor synergism was seen for the combination of teicoplanin and aminoglycosides using the checkerboard method. Using time-kill curves synergism was often found for the combination of teicoplanin and netilmicin (even at sub-minimal inhibitory concentrations of netilmicin) and for the combination of teicoplanin and cephalotin. No antagonistic interactions occurred.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002512:Cephalothin / Q000494:pharmacology*; D004347:Drug Interactions; D005839:Gentamicins / Q000494:pharmacology*; D006020:Glycopeptides / Q000494:pharmacology; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D009428:Netilmicin / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D017334:Teicoplanin
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D006020:Glycopeptides; D009428:Netilmicin; D017334:Teicoplanin; D002512:Cephalothin