Joint inflammations and flare-up reactions in mice induced by a helper T cell clone.
Joint inflammation was induced in mice by cloned helper T cells specific for methylated bovine serum albumin (mBSA). This occurred after local injection of the helper T cells together with mBSA into the knee joint, but also when the helper T cells were intravenously injected and the antigen directly into the joint. Local injection of mBSA several weeks after waning of a joint inflammation induced by cloned helper T cells caused a flare-up reaction, indicating that the helper T cells persisted in the joint after the primary inflammation.
D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000276:immunology* / Q000473:pathology; D002999:Clone Cells; D005260:Female; D007719:Knee Joint / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*