title: [Artificial pancreas in diabetic children].
abstract: The current artificial pancreases, which are not wearable, are mainly used for physiological research. However, they may also become useful tools for clinical or therapeutic investigations in diabetes mellitus. This is clearly demonstrated by our own experience of the Biostator in 300 young diabetics. The steady state regulation of plasma glucose offers a wide range of possible investigations: clinical, such as measuring insulin activity in states of insulin resistance, urinary excretion of glucose and renal threshold; therapeutic, like evaluating the hypoglycemic activity of commercial insulins, or alternative routes of insulin administration, such as the peritoneum; physiopathological, for better evaluation of metabolic alterations in diabetes by measuring the turnover of various substrates. Experience of the artificial pancreas also appears to be crucial for a better handling of the many problems involved in the design of future wearable or implantable devices.
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000628:therapy*; D006801:Humans; D007328:Insulin / Q000097:blood; D007332:Insulin Infusion Systems / Q000009:adverse effects; D007333:Insulin Resistance
chemical_list: D001786:Blood Glucose; D007328:Insulin
vernacular_title: Pancréas artificiel chez l'enfant diabétique.