Characterization of Japanese encephalitis virus-specific suppressor T cells and their product in suppression of the humoral immune response in mice.
Since Japanese encephalitis virus (JEV) induces the generation of suppressor T cells in mouse spleen which, through the production of a soluble suppressor factor (SF), suppress IgM plaque-forming cells (IgM-PFC) the present study was undertaken to further characterize these suppressor cells and the SF. The suppressor cells were Ly1-2+ and sensitive to hydrocortisone and a high dose of irradiation. SF was trypsin-sensitive, thermolabile and non-dialysable, and passed through a 450-nm filter. This SF was shown to be a low molecular weight substance, with an approximate MW of 18,000 daltons.
D000818:Animals; D000950:Antigens, Ly; D004664:Encephalitis Virus, Japanese / Q000276:immunology*; D006854:Hydrocortisone / Q000494:pharmacology; D051379:Mice; D008970:Molecular Weight; D013154:Spleen / Q000276:immunology; D013491:Suppressor Factors, Immunologic / Q000276:immunology* / Q000302:isolation & purification; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects
D000950:Antigens, Ly; D013491:Suppressor Factors, Immunologic; D006854:Hydrocortisone