Interaction of tetrachlorobiphenyls with isolated rat liver mitochondria.
A comparative study of the effects of tetrachlorobiphenyls (TCBs) on the succinate-supported respirations of rat liver mitochondria was made, and some differences in effects caused by the different chlorine positions of the biphenyl rings were clarified. The inhibitory actions of 2,3,2',3'-,2,4,2',4'-, and 2,5,2',5'-TCBs on both state 3 and uncoupler-stimulated respirations were potent, while those induced by 2,6,2',6'-, and 3,4,3',4'-TCBs were weak. 2,3,2',3'-,2,4,2',4'-,2,5,2',5'-, and 2,6,2',6'-TCBs stimulated state 4 respiration, but 3,4,3',4'-TCB had very little effect on this respiration. The latent adenosine triphosphatase activity was stimulated by 2,3,2',3'-,2,4,2',4'-, and 2,5,2',5'-TCBs, but 2,6,2',6'-, and 3,4,3',4'-TCBs had no effects. The relationship between these effects and chemical structure of TCBs is discussed.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D004140:Dinitrophenols / Q000494:pharmacology; D066298:In Vitro Techniques; D007536:Isomerism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D011048:Polarography; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship; D013386:Succinates / Q000378:metabolism
D004140:Dinitrophenols; D013386:Succinates; D011078:Polychlorinated Biphenyls; D000251:Adenosine Triphosphatases