Cross-resistance of menogaril and mitoxantrone in a subline of P388 leukemia resistant to doxorubicin.
Mice bearing the P388/S or P388/ADR (doxorubicin-resistant) leukemia were treated with menogaril or mitoxantrone. Both drugs were highly effective against P388/S but were ineffective against the doxorubicin-resistant subline, indicating cross-resistance. These observations may be of use in the design of clinical trials with these drugs.
D000818:Animals; D000970:Antineoplastic Agents; D001835:Body Weight / Q000187:drug effects; D002460:Cell Line; D003630:Daunorubicin / Q000031:analogs & derivatives*; D004317:Doxorubicin / Q000494:pharmacology*; D004351:Drug Resistance; D007941:Leukemia P388 / Q000188:drug therapy; D008017:Life Expectancy; D017290:Menogaril; D051379:Mice; D008815:Mice, Inbred Strains; D008942:Mitoxantrone / Q000494:pharmacology*; D009621:Nogalamycin / Q000031:analogs & derivatives / Q000494:pharmacology*
D000970:Antineoplastic Agents; D004317:Doxorubicin; D017290:Menogaril; D008942:Mitoxantrone; D009621:Nogalamycin; D003630:Daunorubicin