Suppression of lordosis behavior by the putative 5-HT receptor agonist 8-OH-DPAT in the rat.
The administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), inhibited the lordosis induced by estradiol benzoate or estradiol benzoate plus progesterone in ovariectomized rats. There was no facilitation of lordosis by 8-OH-DPAT in animals pretreated with a threshold dose of estradiol benzoate. The results are consistent with the view that 8-OH-DPAT is an agonist at 5-HT receptors and provide further support for an inhibition role of central 5-HT in the mediation of lordosis behavior.
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D010052:Ovariectomy; D011187:Posture; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D009281:Naphthalenes; D011985:Receptors, Serotonin; D013764:Tetrahydronaphthalenes; D011374:Progesterone; D004958:Estradiol; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin