[Effect of actinomycin D on the post-denervational changes of chemosensitivity in muscle spindles in the cat].
The effect of preliminary injection of the inhibitor of protein synthesis actinomycin D on development of extrajunctional cholinergic receptors in denervated intrafusal muscle in cats, was investigated. Chronic motor denervation of the soleus muscle (3-5 days after denervation) caused supersensitivity of intrafusal muscle fibres to acetylcholine (Ah), subecholine (SCh) and succinylcholine (Sh). Injections of actinomycin D prevented the supersensitivity, the latter being dependent on the synthesis of new cholinoreceptors and their incorporation in the extrajunctional region of intrafusal fibres.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002415:Cats; D002794:Choline / Q000031:analogs & derivatives / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology*; D003714:Denervation; D009470:Muscle Spindles / Q000187:drug effects*; D011950:Receptors, Cholinergic / Q000187:drug effects; D013390:Succinylcholine / Q000494:pharmacology; D013997:Time Factors
D011950:Receptors, Cholinergic; D003609:Dactinomycin; C009335:subecholine; D013390:Succinylcholine; D002794:Choline; D000109:Acetylcholine
Vliianie aktinomitsina D na postdenervatsionnye izmeneniia khemochuvstvitel'nosti myshechnykh vereten koshki.