A suppressor-inducer factor produced by burn trauma-associated T cells.
Six days after a full-thickness scald burn in specific-pathogen free mice, potent suppressive activity was observed in the serum and in supernatants of splenic T cells. The serum activity could be blocked by addition of a monoclonal anti-T suppressor molecule antibody to assay cultures. An examination of the six-day postburn T cell supernatants revealed suppressor inducer T cell (Tsi) activity with a number of characteristics of other Tsi factors described in other systems. These observations further implicate the suppressor T cell pathway in the immunoregulatory sequelae of severe thermal trauma.
D000818:Animals; D002056:Burns / Q000276:immunology*; D007108:Immune Tolerance; D051379:Mice; D008810:Mice, Inbred C57BL; D013047:Specific Pathogen-Free Organisms; D013491:Suppressor Factors, Immunologic / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D013491:Suppressor Factors, Immunologic