title: Evidence from somatic cells for crossing-over in humans.
abstract: Chromosomal and gene marker studies of somatic cells in a family with multiple chromosome translocations show apparent instability of the translocations in transmission from generation to generation. This instability is attributed to meiotic crossing-over between the involved chromosomes. Technical advances in chromosome analysis combined with human gene map information in the study of this unusual family demonstrate for the first time that crossing-over involves exchange of chromatin between nonsister chromatids of homologous chromosomes.
mesh_terms: D002871:Chromosome Banding; D002874:Chromosome Mapping; D003434:Crossing Over, Genetic; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D007621:Karyotyping; D008297:Male; D008540:Meiosis; D010375:Pedigree; D010733:Phosphoglucomutase / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: D007527:Isoenzymes; D010733:Phosphoglucomutase