[Role of helper T-lymphocytes in modulating the humoral immune response to cholera enterotoxin].
The role of helper T-lymphocytes in the modulation of humoral immune response to sheep red blood cells with choleragen has been studied in vivo, the populations of cooperating marrow cells, formed in mice under the action of hydrocortisone being used as a model. In adoptive transfer marrow cells, taken from mice on day 12 after thymectomy and from mice previously treated with antithymocyte serum, have proved incapable of humoral immune response. Choleragen, similarly to theophylline, normalizes the humoral immune response of marrow cells in thymectomized mice, but inhibits this response in intact ones, while thymosin fraction 2 restores it again, thus abolishing the action of choleragen and theophylline. The opposite effects rendered by choleragen and theophylline on humoral immune response, depending on the hormonal status of the animals and the possibility of influencing these effects by means of thymosin fraction 2 indicate that the population of helper T-lymphocytes are selectively sensitive to changes in the concentration of intracellular cAMP. Their capacity for cooperative interaction in the immune process is regulated by thymic hormones and forms the basis of the mechanism permitting the modulation of humoral immune response with choleragen.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D001853:Bone Marrow / Q000187:drug effects / Q000276:immunology; D016026:Bone Marrow Transplantation; D004768:Enterotoxins / Q000276:immunology*; D006854:Hydrocortisone / Q000494:pharmacology; D007116:Immunization, Passive; D008211:Lymphocyte Cooperation / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010446:Peptide Fragments / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology*; D013806:Theophylline / Q000494:pharmacology; D013934:Thymectomy; D013947:Thymosin / Q000494:pharmacology; D013997:Time Factors; D014734:Vibrio cholerae
D004768:Enterotoxins; D010446:Peptide Fragments; C037420:stN protein, Vibrio cholerae; D013947:Thymosin; D013806:Theophylline; D006854:Hydrocortisone
Rol' vspomogatel'nykh T-limfotsitov v moduliatsii gumoral'nogo immunnogo otveta kholernym énterotoksinom.