Natural killer cell interaction with IgE in the control of ongoing human IgE synthesis.
Fresh natural killer (NK) cells from normal donors inhibited IgE synthesis from U266/AF-10 cells via a direct cytolytic effect. This inhibition was 'reversed' by incubation of NK cells with human IgE-anti-IgE immune complexes (IgE-IC) for 16 h without a decrease in NK-mediated cytotoxicity. Upon incubation with IgE-IC, Fc epsilon receptors (FcER) were induced on 3-9% of NK cells. These IgE-IC induced FcER+ NK cells from normal donors secreted (an) IgE-specific factor(s) which enhanced U266/AF-10 IgE production without increasing DNA synthesis. Production of this IgE differentiation factor(s) explains the apparent reversal of NK cell inhibition of IgE production.
D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000276:immunology*; D002460:Cell Line; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology / Q000473:pathology; D007108:Immune Tolerance; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D010954:Plasmacytoma; D011961:Receptors, Fc / Q000276:immunology; D017455:Receptors, IgE
D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D011961:Receptors, Fc; D017455:Receptors, IgE; C026408:anti-IgE antibodies; D007073:Immunoglobulin E