title: A multivariate pattern recognition study of risk-factors indicating postoperative thromboembolism despite low-dose heparin in major abdominal surgery.
abstract: The object of the present investigation was to identify those who, among high-risk patients, would "break through" low-dose heparin prophylaxis and develop thromboembolism after major abdominal surgery. Twenty-nine variables (clinical characteristics, pre- and postoperative coagulation and fibrinolytic factors) from 19 patients with and 26 patients without thromboembolism were analyzed by means of a multivariate supervised pattern recognition technique (SIMCA). We found no statistically significant difference between patients with and without thromboembolism. Thus, in the studied group of high-risk patients it was not possible to identify a predictive index for selection of individual patients liable to develop postoperative thromboembolism despite low-dose heparin prophylaxis in major abdominal surgery.
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000328:Adult; D000367:Age Factors; D000368:Aged; D005163:Factor Analysis, Statistical; D005260:Female; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010976:Platelet Count; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D012306:Risk; D012701:Serotonin / Q000097:blood; D013923:Thromboembolism / Q000097:blood / Q000209:etiology* / Q000517:prevention & control; D065227:Transfusion Reaction; D014882:Water-Electrolyte Balance; D001620:beta-Thromboglobulin / Q000378:metabolism
chemical_list: D001620:beta-Thromboglobulin; D012701:Serotonin; D006493:Heparin