Analysis of time to stabilization in the treatment of depression: biological and clinical correlates.
The discovery of clinical and biological variables which correlate with the rate of treatment response is an important aim of outcome research. In this report, such items were assessed in a large group of patients with recurrent depression to determine what variables contribute to stabilization during treatment. Relatively few items were strongly related to time to stabilization aside from age, clinical severity of illness, and number of previous episodes. One biological variable, cortisol nadir, was positively related to the time of stabilization. Similar assessments of non-responders did not yield any specific predictors.
D000328:Adult; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000175:diagnosis / Q000628:therapy*; D003907:Dexamethasone; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D011613:Psychotherapy; D011930:Reaction Time / Q000187:drug effects; D012894:Sleep Stages / Q000187:drug effects
D003907:Dexamethasone; D007099:Imipramine; D006854:Hydrocortisone