Cell-associated IgM, but not IgD or I-A/E, is important in the activation of suppressor T cells by antigen-primed B cells.
The ability of transferred antigen-primed immune B cells to induce T cell-mediated suppression of the antibody response to Type III pneumococcal polysaccharide (SSS-III) could be blocked or eliminated by prior treatment of B cells with F(ab')2 anti-Ig or anti-IgM antibodies; however, F(ab')2 anti-IgD antibodies, or M5/114 (monoclonal anti-I-A/E antibody), had no effect on activation of suppression by SSS-III-primed B cells. Thus, cell-associated IgM antibody plays an important role in the activation of suppressor T cells during the antibody response to SSS-III.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000276:immunology*; D002634:Chemotaxis, Leukocyte; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007108:Immune Tolerance; D007072:Immunoglobulin D / Q000276:immunology; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000907:Antibodies, Bacterial; D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen; D007072:Immunoglobulin D; D007140:Immunoglobulin Fab Fragments; D007075:Immunoglobulin M; D011135:Polysaccharides, Bacterial; D011947:Receptors, Antigen, B-Cell; C039951:anti-IgD; C044203:anti-IgM; C026604:pneumococcal polysaccharide, type III