title: Responses of monkey, rabbit and dog internal carotid arteries to atrial natriuretic factor.
abstract: Effects of atrial natriuretic factor (ANF) on monkey, rabbit and dog internal carotid arteries were investigated. ANF caused a concentration-dependent relaxation in arterial strips submaximally precontracted with noradrenaline, 5-hydroxytryptamine, or high-potassium solution (10-30 mM). The response was greatest in the monkey arteries and least in the dog arteries. These results suggest that there is a marked species difference in the ANF-induced relaxation of the internal carotid arteries.
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002343:Carotid Artery, Internal / Q000187:drug effects / Q000502:physiology*; D004285:Dogs; D066298:In Vitro Techniques; D008251:Macaca; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology
chemical_list: D012701:Serotonin; D011189:Potassium Chloride; D009320:Atrial Natriuretic Factor; D011433:Propranolol; D009638:Norepinephrine