Transfusion-induced, Fc gamma-receptor-blocking antibodies: spectrum of cellular reactivity.
In this study we have shown that transfusion-induced Fc gamma R-blocking antibodies have the capacity to react with various cell types which are known to possess this receptor i.e., lymphocytes (T and B cells), polymorphs and platelets. In contrast we were unable to demonstrate any reactivity with K (or NK) lymphocytes or with monocytes. The spectrum of cellular reactivity exhibited by these antibodies suggests that their effect on the immune system may be complex.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D001667:Binding, Competitive; D001792:Blood Platelets / Q000187:drug effects; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D011961:Receptors, Fc / Q000276:immunology*; D017452:Receptors, IgG; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
D000906:Antibodies; D007074:Immunoglobulin G; D011961:Receptors, Fc; D017452:Receptors, IgG