[Immunopathological study of acute interstitial nephropathy induced by clometacin].
Clometacin is an antalgic drug with a chemical structure very similar to that of indomethacin; it is widely used in France. We report evidence for a cell-mediated immune mechanism in the pathogenesis of clometacin-induced acute interstitial nephritis. In the interstitial infiltrate of a female patient presenting with this condition, T cells constituted 75% of the total lymphocyte population. Cytotoxic/suppressor T cells predominated over helper/inducer T cells with a ratio of two to one. IgA-secreting plasmocytes were also present (about 23% of the inflammatory infiltrate). Peripheral blood lymphocyte studies showed that pre-incubation of the patient's cells with clometacin resulted in an increased sensitivity to interleukin 2 and a positive syngeneic mixed lymphocyte culture. This study seems to be relevant to the pathogenesis of acute interstitial nephritis induced by nonsteroidal anti-inflammatory drugs.
D000208:Acute Disease; D000368:Aged; D000700:Analgesics / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007210:Indoleacetic Acids / Q000009:adverse effects*; D007668:Kidney / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology; D009395:Nephritis, Interstitial / Q000097:blood / Q000139:chemically induced* / Q000276:immunology
D000700:Analgesics; D007210:Indoleacetic Acids; C017136:clometacin
Etude immunopathologique d'une néphropathie interstitielle aiguë induite par la clométacine.