Evaluation of the intensity and duration of the bronchodilatory action of fenoterol-ipratropium bromide in combination compared with terbutaline and placebo in patients with chronic obstructive lung disease.
The effect obtained using terbutaline and Duovent was studied in a group of 16 patients with chronic obstructive lung disease. The drugs were administered by aerosol in doses based on spirometric indices of flow and lung capacity. The results obtained confirm the efficacy of the two drugs in improving gas flow. This improvement persisted for 6-7 h after administration. Comparison of the two drugs has shown that as far as FVC is concerned, the improvement obtained with Duovent is longer-lasting than that with terbutaline. There were no side-effects.
D000368:Aged; D001286:Atropine Derivatives / Q000627:therapeutic use*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D005260:Female; D005280:Fenoterol / Q000627:therapeutic use*; D005541:Forced Expiratory Volume; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use*; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013726:Terbutaline / Q000627:therapeutic use*; D013997:Time Factors; D014797:Vital Capacity
D001286:Atropine Derivatives; D001993:Bronchodilator Agents; D004338:Drug Combinations; D005280:Fenoterol; D009241:Ipratropium; D013726:Terbutaline