Ketanserin and malignant hyperthermia in pigs.
Four Danish landrace pigs susceptible to MH were challenged with halothane and suxamethonium on six occasions after pretreatment with the serotonin-S2 antagonist ketanserin 0.4 mg/kg (three animals) or 4 mg/kg (three animals). The animals developed typical MH on all occasions despite the pretreatment. Dantrolene remains the only specific drug for prevention and treatment of MH.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature; D002245:Carbon Dioxide / Q000097:blood; D006221:Halothane / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007650:Ketanserin; D007773:Lactates / Q000097:blood; D008305:Malignant Hyperthermia / Q000503:physiopathology*; D010880:Piperidines / Q000494:pharmacology*; D011188:Potassium / Q000097:blood; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013390:Succinylcholine / Q000494:pharmacology*; D013552:Swine
D000959:Antihypertensive Agents; D007773:Lactates; D010880:Piperidines; D012702:Serotonin Antagonists; D002245:Carbon Dioxide; D007650:Ketanserin; D013390:Succinylcholine; D011188:Potassium; D006221:Halothane