Effect of L-dopa on periodic movements in sleep in narcolepsy.
Five narcoleptic patients presenting periodic movements in sleep were investigated during treatment with L-dopa administered together with a decarboxylase inhibitor. One of these patients was also treated with gamma-hydroxybutyrate and zimelidine, and recorded at the sleep laboratory under each condition. L-dopa was effective in controlling periodic movements in sleep in all patients, but gamma-hydroxybutyrate or zimelidine were not. These results are discussed in view of a dopaminergic implication in the pathogenesis of periodic movements in sleep.
D000328:Adult; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D009068:Movement / Q000187:drug effects*; D009290:Narcolepsy / Q000188:drug therapy / Q000503:physiopathology*; D010507:Periodicity; D012890:Sleep / Q000502:physiology*; D012978:Sodium Oxybate / Q000627:therapeutic use; D015031:Zimeldine / Q000627:therapeutic use
D015031:Zimeldine; D007980:Levodopa; D012978:Sodium Oxybate