Genetic variants of enzymes of alcohol and aldehyde metabolism.
The distribution of genetic variants (or gene markers) for alcohol dehydrogenase, aldehyde dehydrogenase, aldehyde oxidase, and aldehyde reductase isozymes has been examined among 12 inbred strains of mice. Electrophoretic variants are described for the major liver and stomach alcohol dehydrogenase isozymes (ADH-A2 and C2); liver, kidney, and stomach aldehyde dehydrogenase isozymes (AHD-1; AHD-2; AHD-4); a liver-specific aldehyde reductase (AHR-A2); and a liver aldehyde oxidase isozyme (AOX-2). Genetically determined activity variants were observed for a testis-specific aldehyde dehydrogenase (AHD-6); liver and kidney aldehyde reductase isozymes (AHR-3 and AHR-4); and the major liver AOX isozyme (AOX-1). These variants may serve as useful gene markers in alcohol research involving animal model studies with inbred strains in mice.
D000426:Alcohol Dehydrogenase; D000429:Alcohol Oxidoreductases / Q000235:genetics*; D000437:Alcoholism / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D042931:Aldehyde Oxidase; D000445:Aldehyde Oxidoreductases / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D004822:Epididymis / Q000201:enzymology; D005819:Genetic Markers; D014644:Genetic Variation; D007527:Isoenzymes / Q000235:genetics*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013270:Stomach / Q000201:enzymology; D013737:Testis / Q000201:enzymology
D005819:Genetic Markers; D007527:Isoenzymes; D000429:Alcohol Oxidoreductases; D000426:Alcohol Dehydrogenase; C019642:alcohol dehydrogenase (NADP+); D000445:Aldehyde Oxidoreductases; D000444:Aldehyde Dehydrogenase; D042931:Aldehyde Oxidase