title: [Comprehensive approach to the clinical study of the administration of dehydroepiandrosterone-sulfate (DHA-S) during the induction of labor].
abstract: Effects of Dehydroepiandrosterone-Sulfate (DHA-S) administration during the induction of labor were analysed comprehensively in 116 cases of primipara without any complications. In all of the patients delivery was induced by means of intravenous drip infusion of oxytocin. DHA-S was given as follows; Group A: no administration of DHA-S, Group B: intravenous drip infusion of 600 mg of DHA-S, Group C: intravenous injection of 200 mg of DHA-S every two hours (max, five times). The duration of the first and second stages of labor was reduced significantly in Group C compared to that of Group A (p less than 0.02). Serum DHA-S and estradiol levels in the patients in Groups B and C were significantly higher than those in Group A during the induction of the labor (p less than 0.05-0.005). The secretion of maternal milk was suppressed transiently by the administration of DHA-S (p less than 0.05-0.005), and there was a significant negative correlation between the total amount of maternal milk secretion and the total dose of DHA-S (r = -0.6320, p less than 0.005). Maternal serum prolactin levels did not change significantly following the administration of DHA-S, but estradiol increased significantly following the administration of DHA-S until 48 hours after delivery. These facts suggested that the intravenous injection of 200mg of DHA-S every two hours was effective in assisting the induction of labor, and the transient suppression of maternal milk secretion due to the administration of DHA-S might be caused by the high level of maternal serum estradiol which was converted from DHA-S in the placenta.
mesh_terms: D000328:Adult; D003687:Dehydroepiandrosterone / Q000009:adverse effects / Q000031:analogs & derivatives*; D019314:Dehydroepiandrosterone Sulfate; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007774:Lactation / Q000187:drug effects*; D010120:Oxytocics / Q000009:adverse effects*; D011247:Pregnancy; D011388:Prolactin / Q000097:blood
chemical_list: D010120:Oxytocics; D003687:Dehydroepiandrosterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D011388:Prolactin