Circulating activated (DR-positive) T lymphocytes in a patient with autoeczematization.
A patient with classical hypostatic dermatitis-related autoeczematization was found to have an elevated ratio of helper to suppressor T lymphocytes and increased circulating activated T cells in the absence of detectable levels of circulating interferon. Despite the high levels of activated T cells, peripheral blood mononuclear leukocytes did not produce interferon spontaneously in culture. These findings suggest that autoeczematization is a form of cell-mediated autoimmunity and that activated T cells and interferon production may be unrelated in vivo.
D000368:Aged; D001327:Autoimmune Diseases / Q000276:immunology*; D004485:Eczema / Q000276:immunology*; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D008297:Male; D012867:Skin / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II