title: [Immunoglobulin A in the sebaceous glands. Light and electron microscopy immunomorphologic detection].
abstract: This paper presents evidence for the presence of immunoglobulin A in human sebaceous glands. Light- and electron-microscopic immune cytochemistry techniques revealed secretory IgA in normal sebocytes and within pilosebaceous ducts. The secretory process corresponds to the well-established production of IgA at the site of other internal body surfaces. Basal and suprabasal sebocytes contain IgA in linear extracellular, as well as aggregated intracellular patterns. However, maximal diffuse concentrations are present at the opening of the pilosebaceous duct. This distribution pattern indicates an antimicrobial protective character of IgA, corresponding to similar functions on mucous membrane surfaces. Thus, another important humoral factor contributing to the complex system of skin-associated lymphoid tissue is postulated.
mesh_terms: D000152:Acne Vulgaris / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D006801:Humans; D007124:Immunoenzyme Techniques; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012627:Sebaceous Glands / Q000473:pathology*
chemical_list: D007071:Immunoglobulin A, Secretory
vernacular_title: Immunoglobulin A in Talgdrüsen. Licht- und elektronenmikroskopischer immunmorphologischer Nachweis.