title: Selective suppression of the anaerobic oropharyngeal microflora with local metronidazole.
abstract: Anaerobic microorganisms of the normal oropharyngeal flora have been shown to be the main pathogens in orofacial infections of odontogenic origin. Reduction of the density of anaerobes in the oral cavity as a prophylactic measure before oral surgery may be a rational way to reduce the frequency of post-operative infections. This report describes a local antibiotic regimen that can reduce anaerobic pathogens in the oral cavity. Over a period of 7 days, 10 healthy individuals applied locally 1.5-2 g of an antibiotic preparation consisting of 0.5% metronidazole in 99.5% Orabase paste three times daily. The paste had antibacterial activity against obligate anaerobic micro-organisms such as bacteroides, fusobacteria and leptotrichia, known pathogens in orofacial infections. Fusobacteria and leptotrichia were eliminated in all subjects. Bacteroides species were eliminated in five subjects and significantly decreased in three subjects. The aerobic microflora was not affected. No new colonisation of the oropharynx was observed during the treatment period. The pre-treatment numbers of different micro-organisms were re-established within 2-9 days after the withdrawal of metronidazole treatment.
mesh_terms: D000328:Adult; D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000302:isolation & purification; D001438:Bacteroidaceae / Q000187:drug effects / Q000302:isolation & purification; D005232:Fatty Acids, Volatile / Q000032:analysis; D005260:Female; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects / Q000302:isolation & purification; D008297:Male; D008795:Metronidazole / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D009960:Oropharynx / Q000382:microbiology*; D010459:Peptococcaceae / Q000187:drug effects / Q000302:isolation & purification; D012463:Saliva / Q000032:analysis / Q000382:microbiology; D013997:Time Factors; D014678:Veillonella / Q000187:drug effects / Q000302:isolation & purification
chemical_list: D005232:Fatty Acids, Volatile; D008795:Metronidazole