The stereoselectivity of serotonin uptake in brain tissue and blood platelets: the topography of the serotonin uptake area.
This review concerns effects of stereoisomers on 5-HT uptake in brain tissue and/or blood platelets. All studies in which at least a pair of stereoisomers were used are considered. Differences between effects of stereoisomers of antidepressants as well as other drugs on 5-HT uptake are discussed. The findings indicate that 5-HT uptake is a stereoselective process. A topographical model of the 5-HT uptake area is proposed, based mainly on comparisons between spatial features of stereoisomers that inhibit 5-HT uptake.
D000409:Alanine / Q000031:analogs & derivatives / Q000494:pharmacology; D000661:Amphetamine / Q000494:pharmacology; D000814:Aniline Compounds / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005473:Fluoxetine / Q000494:pharmacology; D006801:Humans; D008297:Male; D008691:Methadone / Q000494:pharmacology; D008803:Mianserin / Q000031:analogs & derivatives / Q000494:pharmacology; D000078785:Mirtazapine; D009025:Morpholines / Q000494:pharmacology; D009281:Naphthalenes / Q000494:pharmacology; D009340:Nefopam / Q000494:pharmacology; D009627:Nomifensine / Q000494:pharmacology; D017374:Paroxetine; D010880:Piperidines / Q000494:pharmacology; D011817:Rabbits; D012701:Serotonin / Q000378:metabolism*; D013237:Stereoisomerism; D014191:Tranylcypromine / Q000494:pharmacology; D014745:Viloxazine / Q000494:pharmacology; D015031:Zimeldine / Q000031:analogs & derivatives / Q000494:pharmacology
D000814:Aniline Compounds; D000928:Antidepressive Agents; D009025:Morpholines; D009281:Naphthalenes; D010880:Piperidines; D005473:Fluoxetine; D009627:Nomifensine; D008803:Mianserin; D012701:Serotonin; D014191:Tranylcypromine; D015031:Zimeldine; D017374:Paroxetine; D009340:Nefopam; C017578:norzimelidine; D014745:Viloxazine; C020852:indeloxazine; D000078785:Mirtazapine; C025293:alaproclate; D000661:Amphetamine; D000409:Alanine; D008691:Methadone