[Pulmonary and systemic vascular effects of ATP in man].
ATP induced-vasodilation was studied using Striadyne, on pulmonary and systemic arterial bed on 10 patients with stable chronic obstructive pulmonary disease. Such significant effects varied according to the dose: pulmonary vasodilation reached maximal level during low rate infusion (2 mumoles/kg/20 min) and systemic vasodilation was related to the dose. The latter became dominant at maximal dose (5 mumoles/kg/20 min). Simultaneously, on four patients, circulating blood level of ATP was assessed. It increased in proportion with the infusion rate and reached respectively 167% and 149 of baseline level on arterial and mixed venous blood.
D000255:Adenosine Triphosphate / Q000097:blood / Q000494:pharmacology*; D001158:Arteries / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D011652:Pulmonary Circulation / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*
D000255:Adenosine Triphosphate
Effets vasculaires pulmonaires et systémiques de l'ATP chez l'Homme.