[Characteristics of 2 types of antigen-binding T suppressors formed during an immune response using T-T hybridomas and their extracts].
Antigen-binding T cells of mice immunized with low doses of syngenic spleen cells modified by 2,4,6-trinitrophenyl sulphonic acid, were fused with BW 5147.3.13 thymoma subclone. Suppressor hybridomas were not identical in their differentiating antigens and functional activity. Extract from Lyt 1-2+ hybridoma suppressed efferent and afferent limbs of delayed type hypersensitivity (DTH) in recipients sensitized with subcutaneous injection of 3 X 10(7) TNP-SC. Extract from Lyt 1+2+ I-hybridoma suppressed only afferent DTH limb. It is suggested that during DTH induction with low doses of hapten-modified cells the generation of different types of antigen-binding DTH T suppressors takes place.
D000818:Animals; D000937:Antigen-Antibody Reactions; D000938:Antigen-Presenting Cells / Q000276:immunology*; D002478:Cells, Cultured; D006825:Hybridomas / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007114:Immunization / Q000379:methods; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D012397:Rosette Formation; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013945:Thymoma / Q000276:immunology; D013953:Thymus Neoplasms / Q000276:immunology; D013997:Time Factors; D014020:Tissue Extracts / Q000276:immunology*
D014020:Tissue Extracts
Kharakteristika dvukh tipov antigensviazyvaiushchikh T-supressorov, obazuiushchikhsia v khode immunnogo otveta, s pomoshch'iu T-T-gibridom i ikh ékstraktov.