[Halo nevus. In situ study using monoclonal antibodies].
Using immunocytochemical methods the inflammatory-cell infiltrate from 7 halo nevi were studied. Monoclonal antibodies, Cris-1, OKT3, OKT4, OKT8, A47, Edu-1, OKT6 and anti-immunoglobulins were employed. The results shows that the predominant cells in the inflammatory-cell infiltrate were T cytotoxic/suppressor activated lymphocytes. An increased number of epidermal Langerhans cells and IgM deposits in epidermal-dermal junction was also observed. Thus, the results are able to postulate that self-involution of halo nevi was mediated by cytotoxic cellular immune reactions.
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006801:Humans; D007111:Immunity, Cellular; D007075:Immunoglobulin M / Q000032:analysis; D007249:Inflammation; D007801:Langerhans Cells / Q000473:pathology; D008214:Lymphocytes / Q000145:classification; D009506:Nevus / Q000276:immunology* / Q000473:pathology; D012075:Remission, Spontaneous; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D007075:Immunoglobulin M
Halo nevo. Estudio "in situ" con anticuerpos monoclonales.