Anticholinergics and cough.
Ultrasonically nebulized aqueous aerosols enable the study in man of vagal epithelial rapidly adapting receptors. Inhalation of aerosols with low chloride ion concentration causes cough. Bronchodilatation in normal subjects using either inhaled fenoterol or ipratropium inhibits this reflex induced cough. It suggests that pulmonary stretch receptors (slowly adapting receptors) may play a part in modulating the cough reflex in man as has been suggested in cats and rabbits.
D000280:Administration, Inhalation; D000284:Administration, Oral; D000420:Albuterol / Q000627:therapeutic use; D001980:Bronchi / Q000187:drug effects; D003371:Cough / Q000188:drug therapy*; D005280:Fenoterol / Q000627:therapeutic use; D005541:Forced Expiratory Volume; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use; D010276:Parasympatholytics / Q000627:therapeutic use*; D010890:Pirenzepine / Q000627:therapeutic use
D010276:Parasympatholytics; D005280:Fenoterol; D010890:Pirenzepine; D009241:Ipratropium; D000420:Albuterol