Identification of urinary metabolites in rats exposed to the nephrotoxic agent 2,3,4-trimethylpentane.
Branched-chain hydrocarbon-induced nephropathy in male rats was examined using 2,3,4-trimethylpentane. Lesions are elected only in male rats, not in females or in controls. Mechanisms of nephropathy may be the interaction of metabolites with the male rat-specific protein alpha 2u globulin. The identified urinary metabolites of 2,3,4-trimethylpentane in male rats given the hydrocarbon by gavage are 2,3,4-trimethyl-1-pentanol, 2,3,4-trimethyl-2-pentanol and 2,3,4-trimethyl-1-pentanoic acid. Of the C8-isomers, 2,3,4-trimethylpentane dosing leads to the highest incidence of kidney damage in male rats.
D000818:Animals; D002849:Chromatography, Gas / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D007202:Indicators and Reagents; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D010420:Pentanes / Q000633:toxicity / Q000652:urine*; D051381:Rats; D011916:Rats, Inbred F344
D007202:Indicators and Reagents; D010420:Pentanes; C053045:2,3,4-trimethylpentane