title: Influence of valproate and carbamazepine on symmetrical cortical penicillin foci in the rat.
abstract: Two epileptogenic foci were formed in homotopic areas of sensorimotor cortices of both hemispheres by application of penicillin. Both valproate (200 and/or 400 mg/kg i.p.) and carbamazepine (50 and/or 100 mg/kg i.p.) did not significantly alter the synchronization of interictal focal discharges. The incidence of ictal phases was suppressed by both drugs in a dose-dependent manner--higher doses (valproate--400 mg/kg; carbamazepine--100 mg/kg i.p.) fully blocked the seizures. Both drugs did not suppress the projection of focal discharges into the opposite hemisphere but were efficacious against secondary generalization.
mesh_terms: D000818:Animals; D002220:Carbamazepine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D010406:Penicillins; D051381:Rats; D011919:Rats, Inbred Strains; D014635:Valproic Acid / Q000494:pharmacology*
chemical_list: D010406:Penicillins; D002220:Carbamazepine; D014635:Valproic Acid