Dopamine D2 receptors are restricted to the prolactin cells in the rabbit pituitary gland: a combined autoradiographic and immunocytochemical study.
The distribution of dopamine D2 receptors was studied using the autoradiographic technique on rabbit pituitary gland sections incubated in the presence of [3H]spiroperidol. D2 receptors were absent from the intermediate lobe as already reported. In the anterior lobe, the location of D2 receptors exactly overlapped that of the prolactin-producing cells revealed by immunocytochemistry on the sections used for autoradiography. No topographical relationships could be found between the D2 receptors and the TSH-producing cells which are known to be inhibited by dopamine in the rat.
D000818:Animals; D001345:Autoradiography; D005260:Female; D007124:Immunoenzyme Techniques; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism; D010902:Pituitary Gland / Q000166:cytology / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D011817:Rabbits; D011954:Receptors, Dopamine / Q000378:metabolism*; D017448:Receptors, Dopamine D2; D013134:Spiperone / Q000378:metabolism; D013972:Thyrotropin / Q000378:metabolism
D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D013134:Spiperone; D011388:Prolactin; D013972:Thyrotropin; D009074:Melanocyte-Stimulating Hormones