Effects of specific D-1 and D-2 dopamine agonists (LY141865 and SKF-38393) and pergolide on urinary output of rats.
Pergolide, LY141865 and SKF-38393 were compared to clonidine for their effects on urine output in normally hydrated rats. SKF-38393 and LY141865 have been considered to be specific D-1 and D-2 dopamine receptor agonists, respectively. Clonidine had a marked effect to increase urine output (17-18 ml at doses as low as 0.08 mg/kg s.c.), whereas the specific dopamine agonists SKF-38393 (0.32-5 mg/kg s.c.) and LY141865 (0.16-1.25 mg/kg s.c.) did not affect urine output. Pergolide, a nonspecific dopamine agonist, slightly increased urine output at the highest dose (0.64 mg/kg s.c.). Specific dopamine agonists do not increase urine output in normally hydrated rats.
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D003000:Clonidine / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004873:Ergolines / Q000494:pharmacology*; D008297:Male; D010479:Pergolide / Q000494:pharmacology*; D019257:Quinpirole; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2
D001552:Benzazepines; D004873:Ergolines; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D019257:Quinpirole; D010479:Pergolide; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D003000:Clonidine