Role of IgE as a mast cell development co-factor in the differentiation of murine gut-associated mast cells in vitro.
A role of IgE in the differentiation of gut-associated mast cells (MC) was determined in vitro in the presence of a T cell product, interleukin 3 (IL3). The presence of both IL3 and IgE induced MC with higher precursor frequency than that of IL3 alone, by up to nearly 4 times, while IgE alone failed to develop the clonal growth of MC. IgE, but not the other isotype-specific immunoglobulins, augmented the proliferation of IL3-induced MC in the presence of IL3. Thus, IgE acts as a cofactor in the growth and/or differentiation of MC.
D000818:Animals; D002452:Cell Count; D002454:Cell Differentiation; D005260:Female; D006632:Histamine / Q000032:analysis; D007073:Immunoglobulin E / Q000378:metabolism / Q000502:physiology*; D007377:Interleukin-3; D007413:Intestinal Mucosa / Q000166:cytology*; D008221:Lymphoid Tissue / Q000166:cytology*; D008222:Lymphokines / Q000502:physiology*; D008407:Mast Cells / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D011961:Receptors, Fc / Q000032:analysis; D017455:Receptors, IgE; D011971:Receptors, Immunologic / Q000032:analysis; D013234:Stem Cells / Q000166:cytology
D007377:Interleukin-3; D008222:Lymphokines; D011961:Receptors, Fc; D017455:Receptors, IgE; D011971:Receptors, Immunologic; D007073:Immunoglobulin E; D006632:Histamine