[Effect of myelopeptides on the cytolytic activity of T-lymphocytes].
To estimate myelopeptide effect on T-cell immunity a model system-mixed lymphocyte culture (MLC) with routine (1:1) and insufficient (20:1) ratio of reacting and stimulating cells was used. The latter culture was termed weakly immunogenic MLC. Myelopeptides administered into the weakly immunogenic MLC at the beginning of incubation ("0" period) at a concentration of 30 to 90 mkg/ml were shown to increase T-lymphocyte cytolytic activity by 35-50% without affecting cell proliferation. The preparation inserted into the culture on day 3 of incubation activated cytolysis by 20-35%. There was no myelopeptide effect on T-lymphocyte proliferation and cytolytic activity in normal MLC. The preparation is supposed to affect differentiation of T-killer precursors without activating DNA synthesis.
D000818:Animals; D001853:Bone Marrow / Q000276:immunology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D010455:Peptides / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology; D013268:Stimulation, Chemical; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000187:drug effects*
D010455:Peptides; D004247:DNA
Vliianie mielopeptidov na tsitoliticheskuiu aktivnost' T-limfotsitov.