In vitro activity of ciprofloxacin combined with azlocillin.
A ciprofloxacin plus azlocillin broth microdilution checkerboard was evaluated against 125 aerobic gram-negative and gram-positive bacteria. Synergism (sigma FIC less than or equal to 0.5) occurred among 56% of Pseudomonas aeruginosa, 30% of Acinetobacter species, and 40% of Staphylococcus aureus studied. Antagonism (sigma FIC greater than or equal to 2) was present in less than 1% of the organisms.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001390:Azlocillin / Q000494:pharmacology*; D001420:Bacteria, Aerobic / Q000187:drug effects*; D002939:Ciprofloxacin; D004347:Drug Interactions; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D011804:Quinolines; D002939:Ciprofloxacin; D001390:Azlocillin