Hematoporphyrin derivative (Photofrin II) photosensitization of isolated mitochondria: impairment of anion translocation.
Isolated mitochondria have been incubated in the presence of 6 micrograms/ml hematoporphyrin derivative (Photofrin II), and irradiated at lambda = 365 nm. After 2 min irradiation (30 W/m2), a congruent to 50% inhibition of citric cycle intermediates transport is observed with a rather similar photosensitivity for the succinate, citrate or oxaloacetate carriers.
D000818:Animals; D000838:Anions / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D002264:Carboxylic Acids / Q000378:metabolism; D017323:Dihematoporphyrin Ether; D006415:Hematoporphyrins / Q000494:pharmacology*; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects*; D008933:Mitochondrial Swelling / Q000187:drug effects; D010539:Permeability; D051381:Rats
D000838:Anions; D002264:Carboxylic Acids; D006415:Hematoporphyrins; D017323:Dihematoporphyrin Ether