title: Identification of a unique receptor on a group A streptococcus for the Fc region of human IgG3.
abstract: Receptors that bind to the Fc region of all four human IgG subclasses have been described on a number of strains of group A streptococci. In this study, we have demonstrated that these immunoglobulin binding properties are mediated by two distinct Fc receptors. The first receptor, with a Mr of approximately 56,000, binds to human IgG1, IgG2, and IgG4, but not to IgG3. A second receptor, with a Mr of approximately 38,000, binds exclusively to human immunoglobulins of the IgG3 subclass.
mesh_terms: D000818:Animals; D000937:Antigen-Antibody Reactions; D002645:Chickens; D003101:Collodion; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008970:Molecular Weight; D009194:Myeloma Proteins / Q000378:metabolism; D010209:Paper; D011961:Receptors, Fc / Q000032:analysis* / Q000145:classification / Q000276:immunology; D017452:Receptors, IgG; D013205:Staphylococcal Protein A / Q000276:immunology / Q000378:metabolism; D013297:Streptococcus pyogenes / Q000378:metabolism*
chemical_list: D007074:Immunoglobulin G; D009194:Myeloma Proteins; D011961:Receptors, Fc; D017452:Receptors, IgG; D013205:Staphylococcal Protein A; D003101:Collodion