[Activation of suppressor cells of the delayed hypersensitivity response in BALB/c mice infected or immunized with Leishmania mexicana pifanoi].
A T suppressor cell population that specifically shut down delayed hypersensitivity responses (DHR) to the parasite was found in both BALB/c mice chronically infected with Leishmania mexicana pifanoi and in naive mice which had received a single IV supraoptimal dose of killed parasites. At the early phase of infection mice exhibited a transitory state of cell-mediated immunity against the parasite that was abrogated when lesions reached their accelerated phase of growth. Results suggest that in both infected and high-dose immunized mice, the activation of T suppressor cells of DHR is related to antigen overload.
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007894:Leishmania mexicana / Q000276:immunology*; D007896:Leishmaniasis / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000953:Antigens, Protozoan
Activación de celulas supresoras de la respuesta de hipersensibilidad tardia en ratones BALB/c infectados o vacunados con Leishmania mexicana pifanoi.