Differential blood pressure response to atriopeptin III and sodium nitroprusside in conscious rats with adrenal medullectomy.
This study was undertaken to test whether the presence or absence of a functioning adrenal medulla influences the blood pressure response of conscious normotensive rats to a 30 min infusion of vasodilating agents such as atriopeptin III (1 microgram/min i.v.), a synthetic atrial natriuretic peptide, and sodium nitroprusside (8 micrograms/min i.v.). Rats either had their adrenal medulla removed or were sham-operated 8-10 days before the experimental day. The blood pressure lowering effect of sodium nitroprusside, but not that of atriopeptin III, was enhanced in rats with no adrenal medulla.
D000313:Adrenal Medulla / Q000502:physiology* / Q000601:surgery; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004837:Epinephrine / Q000097:blood; D005292:Ferricyanides / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology*; D009638:Norepinephrine / Q000097:blood; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D005292:Ferricyanides; D010446:Peptide Fragments; C049490:atrial natriuretic factor (3-28); D009599:Nitroprusside; D009320:Atrial Natriuretic Factor; D009638:Norepinephrine; D004837:Epinephrine