[Protective role of effectors and T-suppressors of delayed hypersensitivity in mice with a localized staphylococcal infection].
To induce delayed hypersensitivity (DH) in mice, experimental local infection with a small dose of Staphylococcus aureus was used. The production of suppressor cells was shown to occur after the intravenous injection of a large dose of killed staphylococcal culture. Experiments with the use of cell transfer and the treatment of lymphocytes with Thy-1 antiserum in the presence of the complement demonstrated the T-lymphocytic nature of DH and its suppression. The study revealed that the role played by DH in antistaphylococcal immunity was different in the animals infected by the subcutaneous routes; besides, the regulatory action of T-suppressors of DH was established.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D002473:Cell Wall / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013207:Staphylococcal Skin Infections / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013997:Time Factors
D000942:Antigens, Bacterial
Izuchenie zashchitnoĭ roli éffektorov i T-supressorov giperchuvstvitel'nosti zamedlennogo tipa u mysheĭ pri lokalizovannoĭ stafliokokkovoĭ infektsii.