A clinical and experimental study of colostomy blood flow and healing after closure.
Colostomy blood flow and healing have been studied in both man and rat. Laser Doppler velocimetry (LDV) was used to measure flow and showed a significant difference between colostomy blood flow measured at 1 week and at more than 8 weeks after fashioning (p less than 0.002). Hartmann colostomies were constructed in rats and closed at 3 or 6 weeks later. There was a correlation between distal colonic (stump) blood flow and anastomotic bursting pressures 3 days after closure in the 3-week group (r = 0.080; p less than 0.01). Colostomies closed at 6 weeks were significantly stronger than those closed at 3 weeks (p less than 0.02). Collagen concentration in proximal (stoma) colon was higher in the 6-week group compared with the 3-week group prior to anastomosis. There was also a fall in the proximal collagen after anastomosis in both 3- (p less than 0.01) and 6-week groups (p less than 0.01). Poor blood flow measured by LDV and colonic collagen concentration may predict poor healing after colostomy closure. LDV is a non-invasive technique with clinical application in this field.
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D003106:Colon / Q000098:blood supply*; D003125:Colostomy; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow; D012212:Rheology; D014945:Wound Healing
D006909:Hydroxyproline