The mouse Fc receptor for IgG (Ly-17): molecular cloning and specificity.
A cDNA clone encoding the mouse Ly-17+ Fc receptor for IgG, isolated from a myelomonocytic cell line, was sequenced and expression of mRNA and the functional Fc gamma R investigated. The receptor is a 301 amino acid transmembrane glycoprotein with two homologous extracellular domains that are also homologous to members of the Ig superfamily. The receptor has four sites of N-linked glycosylation and a long 94 amino acid cytoplasmic tail. Northern analysis, immune complex binding, and serological studies demonstrate that the receptor encoded by the cDNA clone binds mouse IgG gamma 1/2b and rabbit IgG complexes.
D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal; D000950:Antigens, Ly / Q000235:genetics*; D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005786:Gene Expression Regulation; D005796:Genes; D051379:Mice; D009838:Oligodeoxyribonucleotides / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D011961:Receptors, Fc / Q000235:genetics*; D017452:Receptors, IgG; D012689:Sequence Homology, Nucleic Acid
D000911:Antibodies, Monoclonal; D000950:Antigens, Ly; D009838:Oligodeoxyribonucleotides; D012333:RNA, Messenger; D011961:Receptors, Fc; D017452:Receptors, IgG; D004247:DNA