title: The relapses of cystic acne after isotretinoin treatment are age-related: a long-term follow-up study.
abstract: 89 patients (66 males and 23 females) with severe acne were treated with isotretinoin and were followed up for a period of 6-47 months (mean 14 months) after the end of the therapy. Relapses occurred in 14.6% of the patients. They were not found to be related to the total amount of isotretinoin administered (up to 233 mg/kg); a possible, although not significant, link to sex was observed since relapses occurred in 16.6% males and 8.6% of females. But the age of the patients had a significant bearing on the likelihood of relapses: younger patients relapsed more frequently than older patients.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015474:Isotretinoin; D008297:Male; D012008:Recurrence; D012737:Sex Factors; D013997:Time Factors; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014212:Tretinoin; D015474:Isotretinoin