[Effects of derivatives of Ara-C, 5-fluorouracil and nitrosourea against intracerebral implanted L1210 leukemia].
The effects of Ara-C derivatives, 5-FU derivatives and water-soluble nitrosoureas on L1210 leukemia implanted intracerebrally have been evaluated. Daily treatment with BH-AC showed a similar effect to that of Ara-C and intermittent treatment with BH-AC showed a marked effect. Daily treatment with FT-207, UFT and HCFU, 5-FU derivatives, resulted in more than 50% ILS but the effects of these compounds were inferior to those of ACNU and BH-AC. MCNU, a water-soluble nitrosourea, was effective, but less so than ACNU.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000188:drug therapy*; D003561:Cytarabine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005472:Fluorouracil / Q000031:analogs & derivatives / Q000627:therapeutic use; D007939:Leukemia L1210 / Q000188:drug therapy*; D051379:Mice; D009368:Neoplasm Transplantation; D015376:Nimustine; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D013311:Streptozocin / Q000031:analogs & derivatives / Q000627:therapeutic use; D005641:Tegafur / Q000627:therapeutic use*; D014498:Uracil / Q000627:therapeutic use
D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds; D003561:Cytarabine; D015376:Nimustine; D005641:Tegafur; D014498:Uracil; C014002:GANU; D013311:Streptozocin; C015019:enocitabine; C017367:carmofur; C020766:ranimustine; D005472:Fluorouracil