title: A major advance in the treatment of severe acne.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000378:metabolism; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D015474:Isotretinoin; D012629:Sebum / Q000378:metabolism; D014212:Tretinoin / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D014212:Tretinoin; D015474:Isotretinoin