Time course of hepatic changes produced by medroxyprogesterone acetate in the rat.
The time course of the effects of medroxyprogesterone acetate (MPA) treatment (100 mg/kg, i.p.) on hepatic drug metabolism was investigated in female rats. The findings demonstrate that the maximum effects of MPA on the microsomal enzyme systems, liver weight and protein content were attained within 3-7 days depending on the measured parameter. The blood concentration of MPA reached a constant level of about 120 ng/ml in 3 days. After cessation of MPA administration the induced values decreased to the control level within about 11 days.
D000818:Animals; D004247:DNA / Q000032:analysis; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008099:Liver / Q000032:analysis / Q000187:drug effects*; D008111:Liver Function Tests; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D017258:Medroxyprogesterone Acetate; D008862:Microsomes, Liver / Q000201:enzymology; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011506:Proteins; D004247:DNA; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone