[Evaluation of bile diffusion of piperacillin].
In 10 patients undergoing cholecystectomy peroperative samples of serum, bile and gall bladder tissue were obtained one hour after intravenous injection of 2 g of piperacillin. Measurements were made by high performance liquid chromatography. Mean concentrations of piperacillin were 81.7 +/- 13.6 micrograms/ml in serum (S), 382 +/- 110 micrograms/ml in choledochal bile (CB), 30.8 +/- 8.5 micrograms/ml in gall bladder bile and 10.5 +/- 2.6 micrograms/g of gall bladder tissue. With a CB/S ratio of 4.7, piperacillin may be classified among beta-lactams showing good distribution in the biliary tract. This property would make piperacillin useful against the pathogens usually responsible for biliary tract infections.
D000328:Adult; D001646:Bile / Q000378:metabolism*; D005260:Female; D005704:Gallbladder / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010878:Piperacillin / Q000378:metabolism*
D010878:Piperacillin
Evaluation de la diffusion biliaire de la pipéracilline.