Serotonin-induced head shaking behavior in rats does not involve receptors located in the frontal cortex.
Serotonin-induced head shaking behavior, a response associated with 5-HT2 receptors, was examined in rats with lesions of the frontal cortex because of the high density of 5-HT2 receptors in this area. Head shaking behavior caused by the serotonin precursor, 5-hydroxy-L-tryptophan, or by the serotonergic agonist, quipazine, was unchanged following the complete ablation of the frontal cortex. Although 5-HT2 receptors are associated with the head shake response, this behavior is probably not related to serotonin receptors located in the frontal cortex.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D005625:Frontal Lobe / Q000187:drug effects / Q000502:physiology*; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects*
D011804:Quinolines; D011985:Receptors, Serotonin; D012701:Serotonin; D011814:Quipazine; D006916:5-Hydroxytryptophan