In-vitro susceptibility of mycobacteria to ciprofloxacin.
Two hundred and seventy-six strains of mycobacteria were tested for susceptibility to ciprofloxacin (Bay 0 9867), a 4-quinolone antimicrobial agent. Most strains of Mycobacterium tuberculosis, Myco. fortuitum, Myco. kansasii, Myco. marinum and Myco. xenopi were sensitive to minimum inhibitory concentrations (MICs) of 0.78-1.56 mg/l, equivalent to resistance ratios of 1 or 2. Most strains of Myco. avium-intracellulare and Myco. chelonei required MICs of 12.5 mg/l or more, giving resistance ratios of 8.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin; D003470:Culture Media; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D009164:Mycobacterium Infections / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D011804:Quinolines; D002939:Ciprofloxacin