[Interaction between forskolin and verapamil on spontaneous contractions of isolated guinea pig atria].
Forskolin (0.16-1.3 mumol l-1 produced a concentration-dependent increase in both the isometric contraction and the atrial rate. The effects developed slowly, 5 to 8 minutes after the drug was added into the organ bath. Forskolin produced positive inotropic and chronotropic effects also in the presence of isoprenaline. The effects of forskolin were significantly inhibited in the presence of increased concentrations of verapamil in the organ bath. These results indicate that the action of forskolin is mediated by stimulation of the adenylate cyclase system, but in some steps of this action, calcium is also implicated.
D000818:Animals; D016275:Atrial Function; D005576:Colforsin / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology*
D005576:Colforsin; D014700:Verapamil
Interaction entre la forskoline et le verapamil sur les battements spontanés des oreillettes isolées du Cobaye.