[Hematoporphyrin--a new possibility for the tumor diagnosis of central bronchial carcinoma].
The properties of hematoporphyrin (HP) and especially of hematoporphyrin derivative (HPD) result in a certain affinity to tumor tissue. It will be retained longer here than in the surrounding normal tissue, thus building up a gradient 10:1. By radiation with ultraviolet light (405 nm) HPD will emit a strong red fluorescence (600 to 700 nm) which is usable for early detection of cancers under the conditions of fluorescence endoscopy. Lasers are used as light sources for an higher efficiency of light transmission through the channels of instruments. The histological type does not influence the HPD fluorescence. There results no higher rate of complications than with usual endoscopy. For the photosensitivity after application of HPD the patient should observe a sunlight quarantine for 2-3 weeks. The diagnostic sensitivity of the method ranges at 97% and its effectivity near 80%.
D001999:Bronchoscopy; D002283:Carcinoma, Bronchogenic / Q000175:diagnosis* / Q000473:pathology; D005453:Fluorescence; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology
D006415:Hematoporphyrins; D017324:Hematoporphyrin Derivative
Hämatoporphyrin--Eine neue Möglichkeit der Tumordiagnostik bei zentralen Bronchialkarzinomen.