Heterogeneity in vasorelaxant effects of alpha-human atrial natriuretic polypeptide in the dog.
Effects of alpha-human natriuretic polypeptide (ANP) on isolated canine vascular strips were examined in 6 arteries and 5 veins. Under the preconstriction with either methoxamine, prostaglandin F2 alpha or KCl, ANP relaxed the vascular strips to various degrees, depending on the region removed from the circulatory system. The largest relaxation was obtained in the pulmonary artery, suggesting that the pulmonary artery may be an important site of action of ANP.
D000758:Anesthesia; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D015237:Dinoprost; D004285:Dogs; D006801:Humans; D066298:In Vitro Techniques; D008729:Methoxamine / Q000494:pharmacology; D009126:Muscle Relaxation / Q000187:drug effects; D011189:Potassium Chloride / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects; D012077:Renal Artery / Q000187:drug effects; D014665:Vasodilator Agents
D011460:Prostaglandins F; D014665:Vasodilator Agents; D011189:Potassium Chloride; D009320:Atrial Natriuretic Factor; D015237:Dinoprost; D008729:Methoxamine