Enhancement of haematopoiesis-directed suppressor activity in mice following Bordetella pertussis vaccine.
A single injection of killed whole-cell pertussis vaccine (strain 5374) into CBA mice (H-2k) was shown to induce a drastic depletion of cells in the thymus accompanied by the enhancement of suppressor T-cell activity. Thymus cells obtained from pertussis vaccine-treated mice were shown to inhibit the endogenous and exogenous colony formation in the spleen by haematopoietic stem cells (CFUs). Treatment of thymus cells with the anti-I-Jk alloantiserum against a specific marker of suppressor T-cells plus complement abolished the inhibitory effect on CFUs proliferation and had a stimulatory action on the capacity of the marrow CFUs to form macroscopic haematopoietic colonies in the spleen as compared to controls. These results suggest probable involvement of I-J-bearing suppressor T-cells in haematopoietic disorders induced by pertussis vaccine.
D000818:Animals; D001854:Bone Marrow Cells; D003165:Complement System Proteins / Q000276:immunology; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology
D010567:Pertussis Vaccine; D003165:Complement System Proteins