Piroxicam-induced photosensitivity.
During the last 3 years, 9 patients with a photosensitive eruption related to piroxicam therapy were seen. In all but one, it occurred within 4 days of first exposure to the drug. 7 patients required systemic corticosteroids, and 2 hospitalization. Clinical, histological and provocation studies were not conclusive in classifying the eruption as photoallergic or phototoxic. Experimental studies including photohaemolysis, Bacillus subtilis culture and nuclear magnetic resonance showed: (i) in irradiated piroxicam solutions, there was more haemolysis; (ii) in irradiated Petri dishes, piroxicam solutions showed greater inhibition of growth of B. subtilis; (iii) Piroxicam's NMR spectrum is not modified after irradiation. The results provide evidence of piroxicam phototoxic potential.
D000328:Adult; D000368:Aged; D001412:Bacillus subtilis / Q000187:drug effects / Q000528:radiation effects; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006461:Hemolysis / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D010894:Piroxicam / Q000009:adverse effects* / Q000528:radiation effects; D014466:Ultraviolet Rays
D010894:Piroxicam