Different handling of antigen by macrophages of low responder C57BL/10ScSn strain and high responder A/J strain of mice. I. Presentation of antigen and induction of helper and suppressor cells.
The SRBC-pulsed peritoneal macrophages from low IgG producing B10 mice were defective in induction of primary as well as secondary antibody responses in (A/J X B10)F1 recipients. This is most probably due to a low number of Ia+ macrophages in the defective B10 mice. Immunization caused a significant increase in numbers of Lyt 2+ cells in spleens of the B10 strain, whereas the percentage of L3T4+ cells remained unchanged. The opposite situation was found in mice of the high responding A/J strain. Simultaneous application of LPS and SRBC prevented the elevated appearance of Lyt 2+ cells in spleens of low responding B10 mice.
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D000949:Histocompatibility Antigens Class II; D007074:Immunoglobulin G / Q000096:biosynthesis; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D010587:Phagocytosis; D013154:Spleen / Q000166:cytology / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D007074:Immunoglobulin G