title: HLA-DQ structural polymorphism in HLA-DR2 associated HLA-D clusters.
abstract: Three homozygous cell lines with different cellular HLA-D specificities associated with HLA-DR2 including Dw2, Dw12, DB9 displayed structural variation in the products of the DQ locus. Nonglycosylated precursor polypeptides of DQ molecules immunoprecipitated by two-dimensional polyacrylamide gel electrophoresis (2-D gel) revealed distinct differences in the patterns of DQ alpha and DQ beta chains.
mesh_terms: D000911:Antibodies, Monoclonal; D002460:Cell Line; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D005802:Genes, MHC Class II; D006683:HLA-DQ Antigens; D015802:HLA-DR2 Antigen; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D007526:Isoelectric Point; D007959:Lymphocyte Culture Test, Mixed; D008970:Molecular Weight; D011110:Polymorphism, Genetic; D011233:Precipitin Tests
chemical_list: D000911:Antibodies, Monoclonal; D006683:HLA-DQ Antigens; D015802:HLA-DR2 Antigen; D000949:Histocompatibility Antigens Class II