[Effects of ingestion of oxidized fish oils on membrane fluidity, and the activity of hepatic microsome enzymes in rats. Influence of vitamin A overload].
Oxidized fish oil (OFO) feeding is followed in the rat by the increase of vitamin A plasmatic level, and modifications of microsomal membranes (decrease of fluorophore ANS fixation). This inhibit the microsomal increase of cytochrome P 450, mixed function oxidase (MFO), any UDP-glucuronosyl transferases (group I) induced by phenobarbital treatment. On the other hand, vit A over load modify the microsomal structure of the opposite way (increase of ANS fixation). This effect is enlarged when OFO is added. In this case cyt P 450 is decreased. It seems that the magnification of vit. A effect is similar to increased microsomal membrane lability by oxidized fish oil addition.
D000818:Animals; D005395:Fish Oils / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000494:pharmacology*; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D008862:Microsomes, Liver / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D014801:Vitamin A / Q000494:pharmacology*
D005395:Fish Oils; D008054:Lipid Peroxides; D014801:Vitamin A
Effets de l'ingestion d'huiles de poissons oxydées sur la fluidité membranaire, et l'activité des enzymes microsomales hépatiques chez le rat. Influence d'une surcharge en vitamine A.