Cerebral metabolism as measured with positron emission tomography (PET) and [18F] 2-deoxy-D-glucose: healthy aging, Alzheimer's disease and Down syndrome.
Brain metabolism has been measured with positron emission tomography and 18[F] fluoro-2-deoxyglucose. Brain metabolic function remains age invariant in healthy aged subjects 21 to 83 years. Brain metabolism remains unchanged in the mild-moderate severity Alzheimer's disease group and significantly reduced throughout the brain in the late-severe form. Serial assessments over 2 1/2 years of brain metabolic function in an Alzheimer's disease subject with positron emission tomography and 18[F]-fluoro-2-deoxyglucose revealed initial reductions in the parietal lobe and regions prior to neuropsychological changes. Marked elevations in brain metabolism were found in young adult Down syndrome subjects while age-related declines were found in the middle aged (non-demented) Down syndrome subjects and further reductions in the demented Down syndrome individuals.
D000375:Aging; D000544:Alzheimer Disease / Q000378:metabolism* / Q000523:psychology; D001921:Brain / Q000378:metabolism*; D003847:Deoxyglucose / Q000031:analogs & derivatives; D004314:Down Syndrome / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008568:Memory; D010101:Oxygen Consumption; D011868:Radioisotopes; D014055:Tomography, Emission-Computed
D011868:Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose