[Functional and morphologic changes in the cardiovascular system in acute emboligenic arterial obstruction of the extremities].
Cardiovascular function was studied in 129 dogs during temporary occlusion of aortic terminal portions followed by blood flow recovery in the limbs. As ischemia grew in duration, the heart's functional reserves became exhausted, venous tone decreased, while arterial tone, total peripheral resistance and aortic pressure increased, a deficiency of circulating blood volume (CBV) built up, and cardiomyocyte metabolic disorders and lesions were intensified. The recovery of limb blood flow within 2 hours after a three-hour-long ischemia results in the recovery of cardiovascular function. Revascularization following 6 hours' ischemia is associated with the development of latent heart failure. Revascularization after 12 hours of ischemia results in reduced CBV, intropism and vascular tone, and marked metabolic and microcirculatory disorders and cardiomyocyte damage.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002319:Cardiovascular System / Q000503:physiopathology*; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006439:Hemodynamics; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007925:Leriche Syndrome / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000473:pathology*; D006005:Phosphorylases / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism
D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase; D006005:Phosphorylases; D000251:Adenosine Triphosphatases
Funktsional'nye i morfologicheskie izmeneniia serdechno-sosudistoĭ sistemy pri ostroĭ émbologennoĭ arterial'noĭ neprokhodimosti konechnosteĭ.