[Dilator effects of adenosine on rat pancreatic vessels].
The effect of adenosine (an agonist of the P1 purinoceptors) alone or in presence of a specific blocker of these receptors, theophylline, was studied on the vascular flow of the isolated perfused rat pancreas. Adenosine alone at a low concentration (1.65 microM) induced a rapid increase in vascular flow (+ 17%) which lasted throughout the perfusion of the nucleoside. This effect was suppressed by theophylline (50 microM). Our results show that adenosine provokes a dilator effect on the vessels of the rat pancreas and suggest that this effect is due to an action on purinergic receptors of the P1 type.
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D066298:In Vitro Techniques; D007700:Kinetics; D010179:Pancreas / Q000098:blood supply*; D051381:Rats; D011919:Rats, Inbred Strains; D013806:Theophylline / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*
D013806:Theophylline; D000241:Adenosine
Effet dilatateur de l'adénosine sur les vaisseaux du pancréas de rat.