title: Central action of atrial natriuretic polypeptide on blood pressure in conscious rats.
abstract: The effect of intracerebroventricular administration of atrial natriuretic polypeptide on blood pressure was studied in conscious, unrestrained rats. The intracerebroventricular injection of alpha-human atrial natriuretic polypeptide did not promote any significant change in basal blood pressure, whereas it attenuated central angiotensin II-induced pressor response in a dose-dependent manner. The plasma atrial natriuretic polypeptide level did not change after the central administration of alpha-human atrial natriuretic polypeptide. These data implicate atrial natriuretic polypeptide as a factor in blood pressure regulation in the central nervous system.
mesh_terms: D000804:Angiotensin II / Q000008:administration & dosage; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage* / Q000097:blood; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D011311:Pressoreceptors / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000804:Angiotensin II; D009320:Atrial Natriuretic Factor