Atrial natriuretic factor (ANF) levels are elevated in rats bearing rejecting heart-lung allografts.
Intra-abdominal heart-lung grafts were transplanted into 8 rats across a major histocompatibility barrier. Four of the 8 rats were treated with Cyclosporin A (CsA) to prevent rejection. Atrial natriuretic factor (ANF) levels measured 6 days after transplantation revealed a significantly (p less than .005) higher mean ANF concentration in rats bearing a rejecting heart-lung allograft (642 +/- 148.0 pg/ml) compared to rats bearing a heart-lung allograft not undergoing rejection (200.8 +/- 13.07 pg/ml). ANF might be a useful noninvasive marker in the diagnosis of rejection in heart and heart-lung transplants.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood*; D003524:Cyclosporins / Q000494:pharmacology; D005856:Germ-Free Life; D006084:Graft Rejection; D016027:Heart Transplantation; D016041:Heart-Lung Transplantation; D016040:Lung Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D014184:Transplantation, Homologous
D003524:Cyclosporins; D009320:Atrial Natriuretic Factor