Functional activities of enriched Fc receptor bearing T lymphocytes in Hodgkin's disease.
Our earlier studies have demonstrated that the peripheral blood mononuclear cells (PBMNC) of patients with Hodgkin's disease (HD) have reduced percentage of T mu cells and increased percentage of T gamma cells, while the splenic MNC showed the reversed proportions. In this paper, the functional abilities of subsets with these phenotypes have been investigated. T gamma and T mu cells were enriched from theophylline-sensitive and -resistant populations of lymphocytes obtained from PBMNC and splenic MNC of untreated HD patients and normal healthy donors. The effect of addition of these enriched populations on PHA and mixed leukocyte culture (MLC) responses of corresponding autologous MNC has been studied. The results showed that both PHA and MLC responses of normal as well as of HD lymphocytes could be suppressed by T gamma cells, while T mu cells failed to show an appreciable helper activity. The T gamma population in HD, therefore, appears to maintain suppressor function, thereby influencing the peripheral blood T cell responses.
D000911:Antibodies, Monoclonal; D002478:Cells, Cultured; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008934:Mitogens; D010835:Phytohemagglutinins / Q000494:pharmacology; D011961:Receptors, Fc / Q000032:analysis; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
D000911:Antibodies, Monoclonal; D008934:Mitogens; D010835:Phytohemagglutinins; D011961:Receptors, Fc