Expression of glomerular C3b receptor activity in normal human kidneys.
The glomerular C3b receptor (CR1) activity was measured in cryostat sections of 100 normal kidneys obtained at autopsy using haemadsorption of erythrocytes (E) sensitized with rabbit IgM antibodies (A) and human complement (C) (EAC). The CR1 activity was classified as high, intermediate or low according to the degree of haemadsorption of EAC. High glomerular CR1 activity was found in 25% of the kidneys, intermediate activity in 62% and low activity in 12% of the kidneys. EAC did not adhere to glomeruli in 1% of the samples. The distribution of the glomerular CR1 activity is very similar to the phenotypic distribution of CR1 activity on erythrocytes from healthy individuals.
D003165:Complement System Proteins / Q000378:metabolism; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006382:Hemadsorption; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007678:Kidney Glomerulus / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011951:Receptors, Complement / Q000378:metabolism*; D017463:Receptors, Complement 3b
D007136:Immunoglobulins; D011951:Receptors, Complement; D017463:Receptors, Complement 3b; D003165:Complement System Proteins