Effect of quinolinic acid in the nucleus basalis magnocellularis on cortical high-affinity choline uptake.
A transient 45% increase in cortical high-affinity choline uptake (HACU) was observed after an injection of quinolinic acid (QUIN) into the nucleus basalis magnocellularis (nbM) of the rat. This was followed by a steady decline in choline uptake, which resulted in a 46% decrease by day 7. Specific [3H]hemicholinium-3 binding to coronal brain sections showed a similar pattern following injections of QUIN into the nbM. The increase in cortical HACU elicited by QUIN appeared to be dose dependent.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001345:Autoradiography; D001693:Biological Transport, Active / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D002794:Choline / Q000378:metabolism*; D006426:Hemicholinium 3 / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009847:Olivary Nucleus / Q000187:drug effects / Q000502:physiology*; D011725:Pyridines / Q000494:pharmacology*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013238:Stereotaxic Techniques; D014316:Tritium
D000927:Anticonvulsants; D011725:Pyridines; D011805:Quinolinic Acids; D014316:Tritium; D006426:Hemicholinium 3; D017378:Quinolinic Acid; D002794:Choline