Helper and suppressor activities of an autoreactive mouse thyroglobulin-specific T-cell clone.
An autoreactive T-cell clone, MTg9B3, specific for mouse thyroglobulin, has been characterized. This clone has properties consistent with it an being autoreactive T helper cell. It is I-A restricted, with a surface phenotype of Thy 1+, L3T4+, Ly2-, and produces a number of non-specific lymphokine activities following specific triggering with antigen. Furthermore, antigen-stimulated clone cells were capable of providing bystander help in SRBC-specific antibody responses. Surprisingly, MTg9B3 cells had a profound suppressive effect on thyroglobulin autoantibody responses in vitro.
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D002460:Cell Line; D002999:Clone Cells / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance; D007376:Interleukin-2 / Q000096:biosynthesis; D007377:Interleukin-3; D015848:Interleukin-5; D008211:Lymphocyte Cooperation; D008222:Lymphokines / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology*
D001323:Autoantibodies; D007376:Interleukin-2; D007377:Interleukin-3; D015848:Interleukin-5; D008222:Lymphokines; D013954:Thyroglobulin