A re-evaluation of changes in rat striatal D-2 dopamine receptors during development and aging.
High affinity binding of 3H-spiperone to D-2 dopamine receptors was measured in membrane fractions prepared from striata of male Sprague-Dawley rats aged 0.75-25 months. 3H-Spiperone bound with approximately 0.11 nM affinity in all age groups studied. The maximum number of D-2 receptors initially increased with age, peak adult levels being reached by 4 months of age. Receptor density declined by 33% over the next 7 months and no further loss of receptors was apparent between 11 and 25 months of age. Such a time-course suggests a loss of rat D-2 receptors that occurs, at least in this strain, earlier than has previously been appreciated, and appears to be in agreement with preliminary positron emission tomographic studies in living man.
D000375:Aging; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003342:Corpus Striatum / Q000254:growth & development* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D017448:Receptors, Dopamine D2; D013134:Spiperone / Q000378:metabolism
D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D013134:Spiperone; D004298:Dopamine