Characterization of intra-tumoral porphyrin following injection of hematoporphyrin derivative or its purified component.
Photodynamic therapy (PDT) utilizes either hematoporphyrin derivative (Hpd) or a purified form of Hpd termed DHE, as photosensitizers for treatment of a variety of solid tumors in man. The reasons for long retention of these porphyrins in a wide range of histologically diverse tumors remain obscure. We have found that the RIF fibrosarcoma and SMT-F mammary carcinoma in mice, a intrapancreatic tumor in the hamster and a tumor removed from a patient with a myxoid sarcoma, make take up Hpd or DHE by endocytosis. On the other hand the RIF tumor cells in vitro show a tendency for selective uptake and retention of the more hydrophobic components of the mixture.
D000818:Animals; D006224:Cricetinae; D005260:Female; D005354:Fibrosarcoma / Q000378:metabolism*; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000378:metabolism*; D006801:Humans; D008647:Mesocricetus; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D008875:Middle Aged; D011166:Porphyrins / Q000302:isolation & purification / Q000378:metabolism*; D012509:Sarcoma / Q000378:metabolism*; D012513:Sarcoma, Experimental / Q000378:metabolism
D006415:Hematoporphyrins; D011166:Porphyrins; D017324:Hematoporphyrin Derivative