title: Effect of short-term or intermittent hypobaric hypoxia on plasma lipids in young rats.
abstract: Changes in the level of plasma lipids (cholesterol, fatty acids and lipoproteins) were followed in young rats exposed once or repeatedly to hypobaric hypoxia. A single exposure to hypoxia increased the level of LDL lipoproteins but did not influence the concentration of cholesterol and fatty acids in 18-day-old rats. Repeated exposure to hypobaric hypoxia caused a statistically significant increase in the concentration of cholesterol, fatty acids, chylomicra, low density beta-lipoproteins (LDL) and very-low-density beta-lipoproteins (VLDL) in 18-day-old rats, while the level of high-density alpha-lipoproteins (HDL) decreased. In animals that had been repeatedly exposed to hypoxia in their youth, a significant decrease of the LDL lipoprotein fraction was observed at the age of 108 days.
mesh_terms: D000375:Aging / Q000097:blood; D000818:Animals; D001274:Atmospheric Pressure; D002784:Cholesterol / Q000097:blood; D005227:Fatty Acids / Q000097:blood; D005260:Female; D000860:Hypoxia / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005227:Fatty Acids; D008055:Lipids; D008074:Lipoproteins; D002784:Cholesterol