title: Malignant angioendotheliosis involving the nervous system: support for a lymphoid origin of the neoplastic cells.
abstract: The clinical and post mortem findings of a case of malignant angioendotheliosis are described. The patient presented with neurological signs attributable to repeated episodes of cerebral and spinal cord infarction. Histological examination showed multifocal intravascular proliferation of mononuclear cells. Immunocytochemical characterisation of these neoplastic cells supports the recent suggestion that this disease represents an unusual form of intravascular lymphoma, which appears to show a predilection for blood vessels of the nervous system.
mesh_terms: D000951:Antigens, Neoplasm / Q000378:metabolism; D001158:Arteries / Q000473:pathology; D001921:Brain / Q000098:blood supply; D001932:Brain Neoplasms / Q000473:pathology*; D006390:Hemangioendothelioma / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008223:Lymphoma / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating; D015260:Neprilysin; D013116:Spinal Cord / Q000098:blood supply; D013120:Spinal Cord Neoplasms / Q000473:pathology*; D014680:Veins / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm; D015260:Neprilysin