The effect of 13-cis-retinoic acid on sebaceous glands.
The drug, 13-cis-retinoic acid, which has been demonstrated to have a marked effect on nodulocystic acne, probably has several mechanisms of action. This article summarizes the effects on the sebaceous glands, and the accompanying changes in cutaneous lipids that result from 13-cis-retinoic acid therapy. These changes in lipid composition support the concept that linoleate may be of importance in the pathogenesis of acne.
D000152:Acne Vulgaris / Q000188:drug therapy*; D000818:Animals; D002986:Clinical Trials as Topic; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D007536:Isomerism; D015474:Isotretinoin; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000378:metabolism; D050356:Lipid Metabolism; D012627:Sebaceous Glands / Q000187:drug effects*; D012629:Sebum / Q000032:analysis / Q000378:metabolism; D012867:Skin / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology* / Q000627:therapeutic use
D005227:Fatty Acids; D008041:Linoleic Acids; D014212:Tretinoin; D019787:Linoleic Acid; D015474:Isotretinoin