title: Evidence for the role of a siderophore in promoting Vibrio anguillarum infections.
abstract: Vibrio anguillarum strain 775 harbouring the virulence plasmid pJM1 produces a plasmid-mediated siderophore that can crossfeed siderophore-deficient, receptor-proficient mutants of V. anguillarum in vitro. Experimental infections of salmonid fishes with mixtures consisting of the wild-type strain and a siderophore-deficient, receptor-proficient mutant resulted in recovery of both the wild-type and the mutant strain, while in infections with mixtures consisting of the wild-type strain and a siderophore-deficient, receptor-deficient mutant only the wild-type strain could be recovered. These results suggest that the V. anguillarum plasmid-mediated siderophore is produced in vivo in a diffusible form and that it is an important factor of virulence.
mesh_terms: D000818:Animals; D007476:Ionophores / Q000378:metabolism*; D007501:Iron / Q000378:metabolism; D007502:Iron Chelating Agents / Q000378:metabolism*; D012474:Salmon; D017262:Siderophores; D014337:Trout; D014733:Vibrio / Q000378:metabolism / Q000472:pathogenicity*; D014774:Virulence
chemical_list: D007476:Ionophores; D007502:Iron Chelating Agents; D017262:Siderophores; D007501:Iron