Aetiology of pulmonary dysfunction in total hip replacement operations. The influence of nifedipine on the factors involved.
Patients undergoing total hip replacement surgery who developed pulmonary dysfunction (PD) demonstrated evidence of complement activation and increased thromboxane A2 (TXA2) synthesis. In a double-blind study nifedipine (Adalat; Bayer-Miles) was shown to inhibit complement activation and TXA2 synthesis and thus appears to offer protection against PD.
D000368:Aged; D000369:Aged, 80 and over; D002986:Clinical Trials as Topic; D003182:Complement C5 / Q000032:analysis; D004311:Double-Blind Method; D011464:Epoprostenol / Q000097:blood; D005260:Female; D006621:Hip Joint / Q000601:surgery; D006622:Hip Prosthesis; D006801:Humans; D007432:Intraoperative Period; D008171:Lung Diseases / Q000209:etiology* / Q000378:metabolism; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use*; D011183:Postoperative Complications; D011184:Postoperative Period; D011897:Random Allocation; D013928:Thromboxane A2 / Q000097:blood; D001620:beta-Thromboglobulin / Q000032:analysis
D003182:Complement C5; D001620:beta-Thromboglobulin; D013928:Thromboxane A2; D011464:Epoprostenol; D009543:Nifedipine