[Persistent HBsAg antigenemia in newborn infants following intrauterine HBV infection. Cause for the failure of the prevention of perinatal HBV transmission].
In areas with high carrier rates for hepatitis B the combination of hepatitis B immune globulin and hepatitis B vaccine prevent perinatal infection in 90-95% of the newborn infants. Since 1979 the failure of perinatal prevention of hepatitis B infection was observed in only two cases. Evidence of intrauterine infection is presented in these two cases.
D002353:Carrier State / Q000635:transmission; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D017325:Hepatitis B Vaccines; D006513:Hepatitis B e Antigens / Q000032:analysis; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins; D007223:Infant; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D014761:Viral Hepatitis Vaccines / Q000627:therapeutic use*
D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D006513:Hepatitis B e Antigens; D007136:Immunoglobulins; D014761:Viral Hepatitis Vaccines; C045213:hepatitis B hyperimmune globulin
Persistierende HBsAg-Antigenämie bei Neugeborenen nach intrauteriner HBV-Infektion. Ursache des Versagens der perinatalen HBV-Ubertragungsprophylaxe.