Suppression of immunological functions in morphine addicted mice.
Lymphocytes isolated from morphine addicted mice show a number of impaired immunological functions. They include Con A stimulated mitogenesis, NK cell activity, plaque forming cell activity and delayed-type of hypersensitivity. In addition, the met-enkephalin and beta-endorphin level in the lymph nodes of addicted mice were also depressed.
D000818:Animals; D004744:Enkephalin, Methionine / Q000032:analysis; D005260:Female; D006968:Hypersensitivity, Delayed; D007108:Immune Tolerance; D007694:Killer Cells, Natural / Q000276:immunology; D008198:Lymph Nodes / Q000032:analysis; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D009021:Morphine Dependence / Q000276:immunology*; D001615:beta-Endorphin / Q000032:analysis
D004744:Enkephalin, Methionine; D001615:beta-Endorphin