Prohormone processing reactions: discrete stages in the formation of beta-endorphin related peptides.
Analysis of lipotropin from the pars intermedia of bovine pituitary showed that it contained the full COOH-terminal sequence of beta-endorphin. In contrast the beta-endorphin related peptides exhibited a high degree of C-terminal proteolysis. The implications of these findings are discussed with reference to the cellular compartments where the processing reactions take place.
D000818:Animals; D002417:Cattle; D010902:Pituitary Gland / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D001615:beta-Endorphin / Q000096:biosynthesis* / Q000235:genetics / Q000302:isolation & purification; D008083:beta-Lipotropin / Q000378:metabolism
D001615:beta-Endorphin; D008083:beta-Lipotropin