Incorporation of intermediary products of 5-FU anabolism into colorectal cancer.
In 18 patients intermediary anabolic metabolites of 5-FU were measured in normal colonic mucosa and colorectal cancer tissue of intravenous bolus injection or continuous infusion. Higher total concentrations of 5-FU products were found in the cancers when compared with normal colonic tissue. There appeared to be no evidence, however, that some patients had a selectively increased ability to incorporate 5-FU into their tumours. Overall higher concentrations of tumour incorporation of 5-FU were found after bolus injection rather than the infusion method, although this difference is statistically not significant.
D000368:Aged; D003106:Colon / Q000201:enzymology / Q000378:metabolism; D003110:Colonic Neoplasms / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005467:Floxuridine / Q000378:metabolism; D005472:Fluorouracil / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology / Q000378:metabolism; D008297:Male; D012004:Rectal Neoplasms / Q000201:enzymology / Q000378:metabolism*; D014529:Uridine / Q000031:analogs & derivatives / Q000378:metabolism
D005467:Floxuridine; C001943:5-fluorouridine; D005472:Fluorouracil; D014529:Uridine