title: I.v. sedation for conservative dentistry. A comparison of midazolam and diazepam.
abstract: Midazolam and the emulsion formulation of diazepam were compared in a cross-over study in 50 patients undergoing out-patient conservative dentistry, with particular regard to sedation and the quality of recovery. Both agents proved effective, but sedation was achieved more rapidly with midazolam (P = 0.001) and was more effective (P less than 0.02). Significantly greater anterograde amnesia for the dental procedure (P less than 0.001) and a more rapid return to normal activities (P less than 0.02) were found with midazolam. Psychometric testing, however, failed to show any objective differences between the treatments. A mean dose of midazolam 0.14 mg kg-1 was required to achieve sedation equating to 0.29 mg kg-1 of diazepam, although there was considerable variation between individual patients.
mesh_terms: D000293:Adolescent; D000328:Adult; D000762:Anesthesia Recovery Period; D000766:Anesthesia, Dental; D000772:Anesthesia, Local; D001007:Anxiety / Q000517:prevention & control; D001569:Benzodiazepines / Q000008:administration & dosage / Q000494:pharmacology; D003814:Dentistry, Operative; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology; D007275:Injections, Intravenous; D008297:Male; D008874:Midazolam; D008875:Middle Aged; D011597:Psychomotor Performance / Q000187:drug effects
chemical_list: D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; D003975:Diazepam; D008874:Midazolam