Genetic variation in the in vitro veto activity of bone-marrow cells.
Cells exerting a veto type of suppressive activity, that is, suppressing the cytotoxic T lymphocyte formation against the class I major histocompatibility complex antigen on their surface, can be found in different lymphoid tissues, for example, in the bone marrow. In this study we show that there is variation in the vitro veto-cell activity between bone marrow cells derived from different mouse strains: bone marrow cells derived from mice carrying the non-H-2 genes of B10/B6 mice had clearly the strongest veto activity.
D000818:Animals; D001854:Bone Marrow Cells; D005802:Genes, MHC Class II; D014644:Genetic Variation; D008285:Major Histocompatibility Complex; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000502:physiology