Common duct stricture associated with hepatic artery infusion of FUDR.
A case report is presented giving the first detailed description of a benign common duct stricture occurring in a patient receiving hepatic artery infusion of FUDR for metastatic colon cancer. It is postulated that the stricture results from a combination of drug toxicity, and hypoxemia of the duct, with the lesion occurring more often than is recognized. A guide is given for the evaluation of the FUDR-infused patient with suspected nonmalignant duct stricture, and for the methods of alleviating extrahepatic blockage in these individuals.
D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary; D003110:Colonic Neoplasms / Q000473:pathology; D003137:Common Bile Duct Diseases / Q000139:chemically induced*; D003251:Constriction, Pathologic / Q000139:chemically induced; D005467:Floxuridine / Q000008:administration & dosage / Q000009:adverse effects*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000009:adverse effects; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged
D005467:Floxuridine