title: [Recent concepts on cerebral ischemia in humans and their implications in therapeutic evaluations].
abstract: Recent concepts concerning focal cerebral ischaemia in man and resulting from the data obtained with positron emission tomography are reported. The evolutive steps in the ischaemic process are divided into: perfusion reserve; extraction reserve recruitment; ischaemic penumbra; lesional process, and post-lesional developments. Circulatory and metabolic patterns corresponding to these evolutive steps are described and illustrated. The potentials of these data as guide-lines in therapeutic trial methodology are discussed.
mesh_terms: D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D006706:Homeostasis; D006801:Humans; D009336:Necrosis; D010101:Oxygen Consumption; D014055:Tomography, Emission-Computed
vernacular_title: Notions récentes sur l'ischémie cérébrale chez l'homme et implications dans les évaluations thérapeutiques.