title: Target size of dopamine D-1 receptors in rat corpus striatum estimated by binding of the benzazepine 3H-SCH 23390.
abstract: The binding characteristics of 3H-SCH 23390 in rat striatum prepared in potassium phosphate buffer are described. The amount of binding sites labeled by 3H-SCH 23390 decreased monoexponentially when exposed to increasing radiation dose. The molecular weight was determined to 78,000 daltons similar to the molecular mass of 3H-piflutixol binding to D-1 receptor previously reported, however lower than the molecular mass of dopamine D-1 agonist binding sites (Gredal & Nielsen 1987).
mesh_terms: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D000818:Animals; D001552:Benzazepines / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D003342:Corpus Striatum / Q000032:analysis / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000032:analysis / Q000378:metabolism*; D017447:Receptors, Dopamine D1; D013892:Thioxanthenes / Q000378:metabolism
chemical_list: D001552:Benzazepines; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D013892:Thioxanthenes; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; C015448:piflutixol