[Phospholipid methylation in fibroblasts of patients with trisomy 21].
Comparative studies of phospholipid methylation in normal and Down syndrome (trisomy 21) fibroblasts were performed on a series of 7 pairs. Two patients showed an increased phospholipid methylation pathway as compared to the appropriate controls; one patient showed a decreased pathway; and in four patients there was no significant difference. The phospholipid methylation pathway appears to be a minor pathway, as compared to the choline pathway of phosphatidylcholine synthesis and thus does not allow the detection of an eventual disturbance of monocarbon metabolism in Down syndrome.
D002478:Cells, Cultured; D004314:Down Syndrome / Q000378:metabolism*; D005347:Fibroblasts / Q000032:analysis; D006801:Humans; D008745:Methylation; D010743:Phospholipids / Q000302:isolation & purification / Q000378:metabolism*; D012867:Skin / Q000378:metabolism
D010743:Phospholipids
Méthylation des phospholipides dans les fibroblastes de patients atteints de trisomie 21.