title: Atrial natriuretic peptide inhibits glomerular contraction induced by angiotensin II and platelet activating factor.
abstract: Isolated rat glomeruli were incubated with angiotensin II, PAF and atrial natriuretic peptide (ANP). Angiotensin II and PAF produced a significant glomerular contraction as evidenced by the decrease in glomerular cross-sectional area. The addition of ANP abolished this effect. These results suggest that ANP could modulate glomerular filtration rate, not only by inducing changes in intrarenal hemodynamics, but also by preventing the effect of some hormones on the filtration surface and subsequently on the ultrafiltration coefficient.
mesh_terms: D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D066298:In Vitro Techniques; D007678:Kidney Glomerulus / Q000187:drug effects / Q000502:physiology*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010972:Platelet Activating Factor / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010972:Platelet Activating Factor; D000804:Angiotensin II; D009320:Atrial Natriuretic Factor