[Central inhibitory effect of intravenous ketoprofen on the nociceptive flexion reflex in man].
In a double-blind, cross-over study, the nociceptive flexion reflex threshold of the biceps femoris was investigated in 10 healthy volunteers before and after intravenous administration of ketoprofen (100 mg in 5 ml) or placebo (5 ml). A significant difference was observed between the increase of reflex threshold produced by ketoprofen (+ 68%) and that produced by the placebo (+ 17%). These results show that ketoprofen has intrinsic inhibitory properties of the nociceptive flexion reflex, which could be explained by a central depressive effect on the transmission of nociceptive messages.
D000328:Adult; D004311:Double-Blind Method; D004594:Electrophysiology; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007660:Ketoprofen / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009619:Nociceptors / Q000187:drug effects*; D010666:Phenylpropionates / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*; D012684:Sensory Thresholds
D010666:Phenylpropionates; D007660:Ketoprofen
Effet inhibiteur central du kétoprofène intraveineux sur le réflexe nociceptif de flexion chez l'homme.