[Stimulation of expression of IgM and IgG receptors on human thymus lymphocytes after treatment with lactoferrin in vitro].
It was established by immunofluorescence that lactoferrin, one of the heteroorganic thymus antigens, can stimulate the expression of Fc mu and Fcj receptors on thymus lymphocytes. The stimulating effect of lactoferrin on T mu cells is more pronounced with the level of these cells in the thymus being low. Its effect on Tj cells seems independent of their level in the thymus and may be related to their precursor differentiation. It can be assumed that one of the functions of lactoferrin in the thymus is to influence the process of differentiation of T mu and Tj cells and to regulate their level in the thymus. Lactoferrin, like other heteroorganic thymus antigens, may take part in the functional maturation of different subpopulations of thymocytes, including T mu and Tj thymus cells.
D000293:Adolescent; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000276:immunology*; D007781:Lactoferrin / Q000276:immunology*; D007782:Lactoglobulins / Q000276:immunology*; D011961:Receptors, Fc; D017452:Receptors, IgG; D011971:Receptors, Immunologic / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D007141:Immunoglobulin Fc Fragments; D007782:Lactoglobulins; D011961:Receptors, Fc; D017452:Receptors, IgG; D011971:Receptors, Immunologic; C035311:immunoglobulin M receptor; D007781:Lactoferrin
Stimuliatsiia ékspressii retseptorov dlia IgM i IgG na limfotsitakh timusa cheloveka pri deĭstvii laktoferrina in vitro.