title: [Changes in lymphocyte subpopulations in relation to anesthesia procedure].
abstract: 44 patients undergoing comparable gynaecological operations received either halothane- modified neuroleptanaesthesia or a combination of epidural and NLA. Monoclonal antibodies were used to determine 8 different lymphocyte subpopulations in blood samples drawn before and after anaesthesia and on the first postoperative day. Cell populations were counted by fluorescent microscopy. Halothane anaesthesia produced both a depression of T-cells (72.67% preoperatively to 52.79% postoperatively) and of the helper/suppressor ratio (1.46 to 1.10); meanwhile activated T-cells increased from 2.33% to 6.83%. After neuroleptanaesthesia as well as after halothane the HLA-DR positive cells decreased (21.05% to 19.29%; 25.22% to 20.29%). The B-cell fraction was elevated from 2.33% to 6.83% following combined anaesthesia. The potential of the anaesthetics to produce subsequent alterations in host defense is discussed.
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D002045:Bupivacaine; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006221:Halothane; D006801:Humans; D007044:Hysterectomy; D007108:Immune Tolerance / Q000187:drug effects; D007958:Leukocyte Count / Q000187:drug effects*; D008875:Middle Aged; D009458:Neuroleptanalgesia; D013243:Sterilization Reversal; D013601:T-Lymphocytes / Q000187:drug effects*; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects
chemical_list: D006221:Halothane; D002045:Bupivacaine
vernacular_title: Veränderungen von Lymphozytensubpopulationen in Abhängigkeit vom Narkoseverfahren.