Ischemic optic neuropathy secondary to intracarotid infusion of BCNU.
A 39-year-old man with a left parietal malignant glioma was treated with intracarotid infusion of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Five weeks after a second infusion, he developed inferior altitudinal visual field loss and pallid optic disc edema ipsilateral to the injection. Retinal vasculitis is a well-recognized complication of intra-arterial BCNU infusion. It is believed that this patient suffered a similar vasculopathy in the posterior ciliary artery circulation.
D000328:Adult; D001932:Brain Neoplasms / Q000188:drug therapy; D002330:Carmustine / Q000009:adverse effects* / Q000627:therapeutic use; D002343:Carotid Artery, Internal; D005451:Fluorescein Angiography; D005910:Glioma / Q000188:drug therapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D007511:Ischemia / Q000139:chemically induced*; D008297:Male; D009898:Optic Disk / Q000098:blood supply*; D010211:Papilledema / Q000139:chemically induced*; D014794:Visual Fields
D002330:Carmustine