Acceleration of prostacyclin by phenolic compounds acting as tryptophan-like cofactors of prostaglandin hydroperoxidase synthase.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001011:Aorta / Q000187:drug effects; D001792:Blood Platelets / Q000378:metabolism; D002084:Butylated Hydroxytoluene / Q000031:analogs & derivatives / Q000494:pharmacology; D002417:Cattle; D011464:Epoprostenol / Q000096:biosynthesis* / Q000494:pharmacology; D008297:Male; D008861:Microsomes / Q000201:enzymology*; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010636:Phenols / Q000494:pharmacology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D012669:Seminal Vesicles / Q000201:enzymology*; D014364:Tryptophan
D000893:Anti-Inflammatory Agents; D010636:Phenols; D002084:Butylated Hydroxytoluene; C013753:2-aminomethyl-4-t-butyl-6-iodophenol; D014364:Tryptophan; D011464:Epoprostenol; D011451:Prostaglandin-Endoperoxide Synthases