Murine interstitial nephritis. VII. Suppression of renal injury after treatment with soluble suppressor factor TsF1.
We prepared soluble suppressor T cell factor (TsF1) from donor spleens harvested from mice primed with tubular antigen-derivatized lymphocytes to analyze both its functional interactions with a larger suppressor T cell network and its influence on the nephritogenic effector T cell response producing interstitial nephritis to a parenchymal antigen. Our findings indicate that TsF1 is antigen-specific, genetically restricted by I-J in its direct mediation of suppression, and capable of inhibiting the development of interstitial lesions. TsF1 also provides an inducing signal for the activation of effector Ts-2 suppressors following presentation by accessory cells. The induction of a Ts-2 effect, however, requires that the factor-presenting cell and the recipient of such cells share homology at I-J, and that the TsF1, the precursor Ts-2 cells, and the recipient of the Ts-2 effect share the same Igh-V allotype. Finally, the results of this current report clearly demonstrate a possible therapeutic role for soluble suppressor factors in the management of interstitial renal disease.
D000818:Animals; D006183:H-2 Antigens / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007116:Immunization, Passive; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007668:Kidney / Q000473:pathology; D007684:Kidney Tubules / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000276:immunology; D009395:Nephritis, Interstitial / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D013154:Spleen / Q000032:analysis; D013491:Suppressor Factors, Immunologic / Q000302:isolation & purification / Q000627:therapeutic use*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D006183:H-2 Antigens; D007143:Immunoglobulin Heavy Chains; D013491:Suppressor Factors, Immunologic