Disparity in HLA-DR typing and mixed lymphocyte culture reactivity.
Prospective HLA-DR matching has been shown to enhance renal graft survival. It has also been demonstrated that the major stimuli in the one-way mixed lymphocyte culture reaction (MLR) are the DR rather than DQ class II histocompatibility antigens. A two antigen DR match between the potential recipient and donor is usually associated with a negative MLR. The findings of two family studies are reported in which HLA-DR identity between the potential recipient and donors did not correlate with the MLR reactivity. These findings further strengthen the need for performing the MLR in conjunction with DR/DQ typing since splits have been described for some of the DR antigens which may not be detected using the currently available commercial typing trays.
D016026:Bone Marrow Transplantation; D005260:Female; D006085:Graft Survival; D006681:HLA-D Antigens / Q000145:classification*; D006683:HLA-DQ Antigens / Q000145:classification; D006684:HLA-DR Antigens / Q000145:classification*; D006801:Humans; D016030:Kidney Transplantation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D010641:Phenotype
D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens