title: Augmentation of the antibody response by hapten help. II. Determination by many genes outside the MHC.
abstract: The purpose of the present work was to characterize the immune response (Ir) genes that influence augmentation of the antibody response by help with the hapten azobenzene-arsonate (ABA). Hapten help was measured as the augmentation in the plaque-forming cell (PFC) response to bovine gamma globulin (BGG) after priming mice with ABA conjugated to ovalbumin (OVA) and challenging subsequently with ABA-BGG. The first approach involved inbred mouse strains that were matched for H-2 but differed in their non-H-2 genetic backgrounds. B10.D2 mice were low responders even though they shared the H-2d haplotype with BALB/c and DBA/2 mice, which were high responders. C57BL/10 mice were high responders even though they shared the H-2b haplotype with C57BL/6, C3H.SW, and A.BY mice, all of which were strains that were low responders. The second approach was to identify any segregation of H-2 with the gene(s) encoding susceptibility to hapten help in the backcross generation. (BALB/c X C57BL/6) F1 hybrids were backcrossed to C57BL/6. The results showed no association with the major histocompatibility complex (MHC).
mesh_terms: D000818:Animals; D000917:Antibody Formation; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000276:immunology; D006238:Haploidy; D006241:Haptens / Q000235:genetics / Q000276:immunology*; D008285:Major Histocompatibility Complex; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics / Q000276:immunology; D008815:Mice, Inbred Strains / Q000235:genetics / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D006183:H-2 Antigens; D006241:Haptens