Relaxant profile of synthetic atrial natriuretic factor on guinea-pig pulmonary tissues.
Synthetic atrial natriuretic factor (ANF) (3.22 X 10(-7)-9.67 X 10(-9) M) produced relaxation of the intrinsic and extrinsic tone of the guinea-pig trachea. ANF was more potent on the trachea as compared to the parenchyma of the guinea-pig. On the trachea ANF was a more potent relaxant of intrinsic tonus or contractions induced by methacholine as compared to contractions induced by leukotriene D4. When administered by aerosol to anesthetized spontaneously breathing guinea-pigs, ANF produced neither bronchodilation nor inhibition of bronchoconstriction induced by an aerosol of leukotriene D4.
D000403:Airway Resistance / Q000187:drug effects; D000758:Anesthesia; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008168:Lung / Q000187:drug effects*; D008170:Lung Compliance / Q000187:drug effects; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology; D009126:Muscle Relaxation / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D013189:SRS-A / Q000494:pharmacology
D008688:Methacholine Compounds; D013189:SRS-A; D009320:Atrial Natriuretic Factor; D007213:Indomethacin