The histology and immunopathology of dermographism.
Twelve patients with dermographism were studied by histological examination. Six spontaneous lesion showed perivascular lymphocytosis. Biopsy of 6 induced lesions showed neutrophiles at 15-30 min and lymphocytes at 1 h or more. One patient biopsied both at 15 min and 2 h showed both microscopic pictures successively. Immunofluorescence of spontaneous or induced lesions in 5 patients was not significant. Studies of T cell subsets of an induced lesion at 30 min showed a moderate number of T helper cells. Mast cell and eosinophile changes were not important. These studies of dermographism imply successive changes with time in perivascular cellular pathology.
D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000145:classification / Q000166:cytology; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology; D014581:Urticaria / Q000150:complications / Q000276:immunology / Q000473:pathology*