Lymphocyte concanavalin A capping: a similarity between Down's syndrome and early onset primary degenerative dementia.
Lymphocyte capping with concanavalin A was studied in adult patients with Down's syndrome and aged patients with primary degenerative dementia. In both disorders a decreased capping was found as compared with age-matched and clinically relevant control groups. Colchicine had a strong enhancing effect on capping in Down's syndrome. In primary degenerative dementia the enhancing effect of colchicine was restricted to a subgroup of patients with onset of the dementing illness before the age of 80 years.
D000328:Adult; D000367:Age Factors; D000368:Aged; D003078:Colchicine; D003208:Concanavalin A / Q000276:immunology*; D003704:Dementia / Q000276:immunology*; D004314:Down Syndrome / Q000276:immunology*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D001523:Mental Disorders / Q000276:immunology; D008870:Microtubules / Q000503:physiopathology; D008875:Middle Aged; D011940:Receptor Aggregation
D003208:Concanavalin A; D003078:Colchicine