[Naloxone does not modify the anti-inflammatory effect of counter-irritation with turpentine].
In the rat, previous injection of turpentine reduced carrageenan-induced oedema. Naloxone and nalorphine did not modify the anti-inflammatory effect of this kind of counter-irritation. Morphine had no influence on carrageenan oedema. These results suggest that endogenous endorphins take no part to the anti-inflammatory effect of counter-irritation by turpentine.
D000818:Animals; D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D004347:Drug Interactions; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D007509:Irritants / Q000494:pharmacology*; D008297:Male; D009269:Nalorphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014425:Turpentine / Q000494:pharmacology* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D007509:Irritants; D009270:Naloxone; D002351:Carrageenan; D009269:Nalorphine; D014425:Turpentine
La naloxone ne modifie pas l'effet anti-inflammatoire de la contre-irritation par térébenthine.