Poison ivy/oak dermatitis. Use of polyamine salts of a linoleic acid dimer for topical prophylaxis.
Closed patch tests were used to evaluate the ability of 156 different preparations (based on 22 different chemicals) to prevent poison ivy dermatitis. Several polyamine salts of a linoleic acid dimer were identified that were totally able to prevent the usual dermatitis in approximately 70% of subjects. The effectiveness of the preparations improved when the antigen and the protectant were washed off within eight to 12 hours, instead of remaining on the skin for 48 hours. When washed off, and depending on the protectant, concentration, and vehicle used, several of the preparations were totally able to prevent a dermatitis in a range of 56% to 100% of subjects tested. Further work with these compounds may greatly benefit the many people currently plagued by their allergy to poison ivy and poison oak.
D000328:Adult; D011040:Dermatitis, Toxicodendron / Q000517:prevention & control*; D004338:Drug Combinations; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000627:therapeutic use*; D008875:Middle Aged; D011073:Polyamines / Q000627:therapeutic use*; D011108:Polymers / Q000627:therapeutic use*; D011409:Propylene Glycols / Q000627:therapeutic use; D012882:Skin Tests
D004338:Drug Combinations; D008041:Linoleic Acids; D011073:Polyamines; D011108:Polymers; D011409:Propylene Glycols; D019787:Linoleic Acid