Liver structure and function during long-term treatment with cyproterone acetate.
Animal experiments and clinical observations have raised the question of liver function in patients on long-term, high-dose administration of sex steroids. The effective treatment of androgenisation demands the prolonged administration of the antiandrogen cyproterone acetate (CPA), which is also a highly effective progestogen. Biochemical tests of liver function and ultrasonographic examinations were performed in 77 women who had been treated with CPA given in the reverse sequential scheme - 100 mg CPA/day from the 1st-10th day combined with 2 mg CPA + 0.05 mg ethinylestradiol/day from the 1st-21st day of each treatment cycle - for 3 to 11 years. No disturbances of the liver structure or function were found.
D000328:Adult; D003534:Cyproterone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D017373:Cyproterone Acetate; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004997:Ethinyl Estradiol / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D008111:Liver Function Tests; D008875:Middle Aged; D013997:Time Factors; D014463:Ultrasonography; D014770:Virilism / Q000188:drug therapy
D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; D003534:Cyproterone