title: Acute influence of cigarette smoke in platelets, catecholamines and neurophysins in the normal conditions of daily life.
abstract: Cigarette smoking is firmly linked to the occurrence of acute coronary events. In twenty-two healthy volunteers in normal conditions of daily life we studied the acute influence of smoking on the following parameters: beta-thromboglobulin, thromboxane B2, epinephrine, norepinephrine, estrogen-stimulated neurophysin, and nicotine-stimulated-neurophysin. Our results show that in our population and following our protocol, smoking did not induce platelet activation, thromboxane formation, catecholamine release or estrogen-stimulated-neurophysin secretion. However, smoking did provoke a significant increase of nicotine-stimulated-neurophysin (p less than 0.05) which reflects vasopressin increase and which might explain the high incidence of ischaemic accidents in cigarette smoking via the vasoactive properties of vasopressin.
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects*; D004837:Epinephrine / Q000097:blood*; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009481:Neurophysins / Q000378:metabolism*; D009638:Norepinephrine / Q000097:blood*; D012907:Smoking; D013268:Stimulation, Chemical; D013929:Thromboxane B2 / Q000097:blood; D001620:beta-Thromboglobulin / Q000097:blood
chemical_list: D004967:Estrogens; D009481:Neurophysins; D001620:beta-Thromboglobulin; D013929:Thromboxane B2; D009638:Norepinephrine; D004837:Epinephrine