[Suppressor cell activity in patients with undifferentiated collagenoses].
Undifferentiated connective tissue syndromes (UCTS) have been considered as early stages of classical rheumatic diseases. We have studied the immunoregulatory function of T8+ cells from patients with UCTS by measuring the effects on pokeweed-mitogen-induced immunoglobulin production. Compared with normals the suppressor activity of T8+ cells was shown to be markedly diminished. These results indicate that an abnormality in generation of suppressor function may be a general feature of early stages of rheumatic diseases.
D000328:Adult; D002478:Cells, Cultured; D003095:Collagen Diseases / Q000276:immunology*; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology*
Suppressorzellaktivität bei Patienten mit undifferenzierten Kollagenosen.