Effects of cyclosporin A on the production of experimental anti-erythrocyte autoantibodies in mice.
Mice were treated with cyclosporin A (CsA) (25-100 mg/kg daily, by mouth) during the induction of autoantibodies to erythrocytes by means of injections of rat erythrocytes. A high dose of CsA inhibited autoantibody production whereas a low dose temporarily potentiated it. Cell transfer and anti-Thy 1.2 treatment indicated the presence of suppressor T cells in the spleens of immunized mice. Their formation was inhibited by treatment with high dose CsA and potentiated by low dose CsA. In the CBA/H mice used, CsA treatment after immunization had no effect on autoantibody titres.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001323:Autoantibodies / Q000096:biosynthesis*; D003524:Cyclosporins / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007114:Immunization; D007116:Immunization, Passive; D051379:Mice; D008808:Mice, Inbred CBA; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology
D000961:Antilymphocyte Serum; D001323:Autoantibodies; D003524:Cyclosporins