Inhibition of suppressor T lymphocytes by murine interferon beta.
We have presented data showing that IFN-beta at 1,000 U/mouse i.v. inhibits the generation of Ts-mediated tolerance to dinitrofluorobenzene (DNFB) and abrogates the transfer of suppression by Ts. We have also presented data showing that IFN-beta up to 10,000 U/mouse i.v. has no adverse effect on sensitization and elicitation. IFN-beta appears to be a suitable agent for evaluation as an adjunct in the immunotherapy of Ts inducing tumors.
D000818:Animals; D000941:Antigens / Q000276:immunology; D004139:Dinitrofluorobenzene / Q000276:immunology; D007108:Immune Tolerance; D007370:Interferon Type I / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology / Q000637:transplantation; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000941:Antigens; D007370:Interferon Type I; D004139:Dinitrofluorobenzene