Water-based versus alcohol-based benzoyl peroxide preparations in the treatment of acne vulgaris.
Forty-eight patients with acne vulgaris in the face were treated with a water-based (Basiron) and an alcohol-based (Panoxyl) 5% benzoyl peroxide preparation. A randomized double-blind, contralateral study was used. No difference in clinical effect was found. Treatment for 8 weeks resulted in at least 50% reduction in the number of closed comedones, papules and pustules in over 80% of the patients. In more than 70% of the patients, the reduction exceeded 75%. The water-based Basiron caused significantly less skin irritation than the alcohol-based preparation of Panoxyl.
D000152:Acne Vulgaris / Q000188:drug therapy*; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D001585:Benzoyl Peroxide / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D003877:Dermatitis, Contact / Q000209:etiology; D004311:Double-Blind Method; D004890:Erythema / Q000139:chemically induced; D000431:Ethanol; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D010545:Peroxides / Q000008:administration & dosage*; D011897:Random Allocation; D014867:Water
D005782:Gels; D010545:Peroxides; D014867:Water; D000431:Ethanol; D001585:Benzoyl Peroxide