The action of calcium antagonists in the human natural killer cell-mediated cytotoxicity.
The Ca2+-channel blocker Nifedipine and the Calmodulin inhibitor Prothazin suppressed the human NK-mediated cytolysis. Both drugs exerted the same dose-dependent effect. The inhibition was partially reversible after withdrawing of the Ca2+-antagonists. There exists evidence that neither effector-target cell binding, nor effector cell function, but the initiation of the target cell lysis was affected by these inhibitors. Hence, the Ca2+-requirement of the NK cytotoxic reaction seems to be due to an essential Ca2+-influx into the target cell.
D002460:Cell Line; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects*; D007951:Leukemia, Myeloid; D009543:Nifedipine / Q000494:pharmacology*; D011398:Promethazine / Q000494:pharmacology
D011398:Promethazine; D009543:Nifedipine