Effects of calmodulin antagonists Cd2+ and trifluoperazine on mixed lymphocyte culture cell-mediated lysis and antibody-dependent cell cytolysis.
The effects of two substances with calmodulin-antagonistic properties, cadmium and trifluoperazine, were studied on mixed lymphocyte culture-cell mediated lysis (MLC-CML) and antibody-dependent cell cytolysis (ADCC). Both cadmium and trifluoperazine readily inhibited MLC-CMC, while ADCC was inhibited only to a small extent or not at all. Trifluoperazine almost completely inhibited phagocytosis in cells whose ability to lyse antibody-coated red blood cells was unimpaired. The results suggests a striking difference in the extent in which calmodulin mediated processes take part in MLC-CML on the one hand and ADCC on the other. This indicates a profound dissimilarity in the mechanisms of these two types of cell-mediated lysis.
D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects*; D002104:Cadmium / Q000494:pharmacology*; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D010587:Phagocytosis / Q000187:drug effects; D014268:Trifluoperazine / Q000494:pharmacology*
D002104:Cadmium; D014268:Trifluoperazine