title: Percutaneous transluminal coronary angioplasty in patients with spasm superimposed on atherosclerotic narrowing.
abstract: Of 552 patients undergoing percutaneous transluminal coronary angioplasty 102 had coronary artery spasm superimposed on atherosclerotic narrowing. Coronary angioplasty was successful in 97 (95%). The patients were discharged on a regimen of nifedipine (40-60 mg/day). Seventy six patients were symptom free 6-8 months after the procedure. Restenosis was detected in 35% of patients. Coronary artery spasm was provoked in 38 (44%) of the 87 patients who underwent an ergometrine maleate test. Twenty seven of the 34 patients with restenosis had a provocation test and coronary artery spasm was superimposed on restenosis in 22 (81.5%). Coronary angioplasty is feasible in patients with coronary artery spasm superimposed on atherosclerotic narrowing but the rate of restenosis is high and coronary artery spasm could have a role in the pathogenesis of restenosis.
mesh_terms: D000800:Angioplasty, Balloon; D003131:Combined Modality Therapy; D003324:Coronary Artery Disease / Q000150:complications / Q000628:therapy*; D003329:Coronary Vasospasm / Q000150:complications / Q000628:therapy*; D004176:Dipyridamole / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use
chemical_list: D004176:Dipyridamole; D009543:Nifedipine