An intrinsic suppressor cell-controlling formation of autologous rosettes in peripheral mouse lymphocytes.
The existence of intrinsic suppressor cell-controlling autologous rosette formation in mouse peripheral blood lymphocytes was demonstrated. This cell is glass adherent, Thy 1,2 positive, and loses its activity after treatment with monoclonal anti-Lyt 2 antibodies plus complement. Suppression of the autologous rosette formation also involves a factor released by these cells directed against autologous erythrocytes. The suppressive phenomenon is strain specific.
D000818:Animals; D005260:Female; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012397:Rosette Formation; D013045:Species Specificity; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*