[Comparative evaluation of cardiotropic effects of nicamag, panangin and asparkam].
Experiments on 75 dogs with experimental myocardial infarction were made to study and compare the therapeutic effect of nicamag (a mixture of potassium and magnesium nicotinates) in a dose of 10 mg/kg, panangin and asparkam (potassium and magnesium aspartates). Nicamag rapidly precipitated postinfarction arrhythmia and made the ECG completely return to normal in the majority of cases. A beneficial effect of the drug on carbohydrate, energy and electrolyte metabolism in the myocardium was discovered to underlie the above-described action. Nicamag abruptly lowered the titers of cardial antibodies, increased the fibrinalytic activity of the blood which is accounted for by the effect of the anion--nicotinic acid.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives*; D004285:Dogs; D004338:Drug Combinations; D004734:Energy Metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D009203:Myocardial Infarction / Q000188:drug therapy*; D009206:Myocardium / Q000378:metabolism; D011195:Potassium Magnesium Aspartate / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D014665:Vasodilator Agents / Q000627:therapeutic use*
D004338:Drug Combinations; D007773:Lactates; D011773:Pyruvates; D014665:Vasodilator Agents; C024653:Asparkam; D001224:Aspartic Acid; D019344:Lactic Acid; D011195:Potassium Magnesium Aspartate; D019289:Pyruvic Acid; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases
Sravnitel'naia otsenka kardiotropnogo vliianiia nikamara, panangina i asparkama.