[Correlation between the steady state and turnover of gamma-aminobutyric acid during brain maturation in mice].
In 2 inbred strains of mice (C57Bl/6J, DBA/2J) in 15 areas, the in vivo GABA turnover rates are significantly correlated with the GABA steady-state levels in 21 day-old mice. In 3 month-old mice the correlation stands only in some areas, the same ones in the 2 strains: olfactory bulbs, frontal cortex, septum, amygdala, hypothalamus, hippocampus, cerebellum. Moreover, the turnover rates decrease sharply with age.
D000375:Aging; D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D007700:Kinetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009928:Organ Specificity; D013045:Species Specificity; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid
Corrélation entre la teneur et le renouvellement de l'acide gamma-aminobutyrique au cours de la maturation du cerveau de Souris.