In vitro activity of A-56268 (TE-031) and four other antimicrobial agents against Chlamydia trachomatis.
The in vitro activity of A-56268 (TE-031), a new macrolide antibiotic, against 11 strains of Chlamydia trachomatis was determined and compared with that of four other antibiotics. A-56268 was the most active drug tested. Doxycycline, trimethoprim-sulfamethoxazole, and erythromycin had good activity but were less active in vitro than A-56268.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002692:Chlamydia trachomatis / Q000187:drug effects*; D002939:Ciprofloxacin / Q000494:pharmacology; D017291:Clarithromycin; D004318:Doxycycline / Q000494:pharmacology; D004338:Drug Combinations / Q000494:pharmacology; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D013420:Sulfamethoxazole / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D002939:Ciprofloxacin; D004917:Erythromycin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D017291:Clarithromycin; D013420:Sulfamethoxazole; D004318:Doxycycline