title: Myocardial protection of hypertrophied hearts by administration of cardioplegia according to regional myocardial temperature.
abstract: Hypertrophied hearts are known to be extremely vulnerable to ischemia. During cardioplegic arrest different regional myocardial temperature are known to occur. We investigated myocardial protection in 61 patients with aortic valve disease undergoing aortic valve replacement. Three different cardioplegic solutions were used. Regional myocardial temperature was continuously controlled and adjusted to a temperature of not more than 15 degrees C by intermittend infusion of cardioplegia. Before, after heart arrest and after 10 minutes of reperfusion we did myocardial biopsies and determined high energy phosphates and lactate. From our results we conclude that three cardioplegic solutions were able to protect hypertrophied hearts adequate during an ischemic period of 60 minutes if the regional myocardial temperature does not increase above 15 degrees C.
mesh_terms: D001831:Body Temperature; D006332:Cardiomegaly / Q000628:therapy*; D006324:Heart Arrest, Induced; D006801:Humans; D008991:Monitoring, Physiologic