Effect of eight-day converting enzyme inhibition on ambulatory blood pressure recordings in normotensive volunteers.
The three angiotensin converting enzyme (ACE) inhibitors cilazapril, perindopril and CGS 14824A were administered for 8 days to, respectively, 6, 5 and 5 normotensive healthy volunteers maintained on an unrestricted salt intake. Before starting treatment, as well as on the last day of therapy, an ambulatory blood pressure profile was obtained with a semi-automatic blood pressure recorder (Remler M2000). An additional blood pressure recording was performed 1 month after the end of the 8-day course of treatment with cilazapril and CGS 14824A. Eight day ACE inhibition with any of the 3 drugs did not result in a consistent decrease of ambulatory blood pressure recordings. This suggests that in normotensive subjects on a free salt intake the renin-angiotensin system may not be a key determinant of blood pressure.
D000328:Adult; D000804:Angiotensin II / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D001552:Benzazepines / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D017315:Cilazapril; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D008297:Male; D020913:Perindopril; D011724:Pyridazines / Q000494:pharmacology
D000806:Angiotensin-Converting Enzyme Inhibitors; D001552:Benzazepines; D007211:Indoles; D011724:Pyridazines; D000804:Angiotensin II; D017315:Cilazapril; C044946:benazepril; D020913:Perindopril