Diuretic and natriuretic action of rat atrial natriuretic peptide (6-33) administered intracerebroventricularly in rats.
Intracerebroventricular (IVT) administration of rat atrial peptide (6-33) (rANP) to conscious male hydrated or salt-loaded rats, resulted in significant increase in urinary volume. The diuretic effects of rANP occurred during the 3 hr period of urine collection and were most effective during the first hour. Most remarkably, rANP given IVT produced a dose-related increase in urinary sodium excretion at 3 hr. With a high dose of rANP, kaliuresis was significant only at 3 hr. Our results strongly suggest that ANF may play a significant role in central regulation of fluid homeostasis, and that its natriuretic and diuretic effects may be, at least in part, centrally mediated.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000494:pharmacology*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004231:Diuresis / Q000187:drug effects*; D007276:Injections, Intraventricular; D007700:Kinetics; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine
D010446:Peptide Fragments; D009320:Atrial Natriuretic Factor; C050513:atrial natriuretic factor prohormone (6-33), rat; D012964:Sodium; D011188:Potassium