Mono- and diacylglycerol lipases in spinal cord of lean and obese Zucker rats.
1. Genetically obese Zucker rats (fa/fa) contain 2-3 times higher activities mono- and diacylglycerol lipases in their spinal cords than their lean littermates. 2. When rats were exercised (1 hr daily, 5 days/week) on a treadmill for 6 months, there was a decrease of about 30% (P less than 0.05) in the activities of mono- and diacylglycerol lipases in lean rats but not in obese animals. 3. High activities of lipases in Zucker obese rats may be related to the elevated levels of beta-endorphin present in these animals. 4. The activities of arylsulfatase, beta-N-acetylhexosaminidase and alkaline phosphatase, tested to check the stability of spinal cord extracts, were similar in lean and obese rat spinal cords.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D004723:Endorphins / Q000378:metabolism; D005260:Female; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008994:Monoacylglycerol Lipases / Q000378:metabolism*; D009765:Obesity / Q000201:enzymology* / Q000235:genetics; D051381:Rats; D011922:Rats, Mutant Strains / Q000378:metabolism*; D011924:Rats, Zucker / Q000378:metabolism*; D013116:Spinal Cord / Q000201:enzymology*; D001615:beta-Endorphin; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism
D004723:Endorphins; D001615:beta-Endorphin; D002265:Carboxylic Ester Hydrolases; D008994:Monoacylglycerol Lipases; D008071:Lipoprotein Lipase; D000469:Alkaline Phosphatase; D001192:Arylsulfatases; D001619:beta-N-Acetylhexosaminidases