Increase of OKT4+ cells during treatment with thymostimulin in parenteral drug addicts with persistent generalized lymphadenopathy.
Thymostimulin (TP-1), a parenterally administered calf thymus extract, has induced a significant increase of OKT4+ peripheral cells in 9 drug addicts with persistent generalized lymphadenopathy; OKT4+ lymphocytes decreased gradually after withdrawal of treatment. In a control group, a spontaneous decrease occurred in the same period of observation. A more prolonged treatment should be undertaken to assess the effectiveness of the drug on the evolution of the disease.
D000328:Adult; D000911:Antibodies, Monoclonal; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000097:blood / Q000188:drug therapy*; D008297:Male; D019966:Substance-Related Disorders / Q000097:blood* / Q000188:drug therapy; D013601:T-Lymphocytes / Q000145:classification / Q000187:drug effects; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects; D013949:Thymus Extracts / Q000494:pharmacology / Q000627:therapeutic use*
D000911:Antibodies, Monoclonal; D013949:Thymus Extracts; C031407:thymostimulin