[Galenic quality of test substances].
According to experimental investigations (microscopy, analytical determination, method of agar diffusion, spreading on human skin) there is no inhomogeneity detectable among the 20 test substances of the Standard-Epicutantest-HERMAL. The following criteria are proved: equal spectrum of the grain sizes, equivalent contents of the active substance along the whole syringe, good release of the active substances from vaseline, homogeneous spreading of the active substances in the syringe, homogeneous spreading on human skin, when Finn Chambers on Scanpor (FCS) and Epiquick plasters are applied. These findings meet the requirements for relevant and reproducible test results.
D002851:Chromatography, High Pressure Liquid; D007464:Clioquinol / Q000009:adverse effects; D006801:Humans; D009532:Nickel / Q000009:adverse effects; D010328:Patch Tests / Q000379:methods*; D014677:Pharmaceutical Vehicles; D012882:Skin Tests / Q000379:methods*
D014677:Pharmaceutical Vehicles; C029938:nickel sulfate; D007464:Clioquinol; D009532:Nickel
Galenische Qualität von Testsubstanzen.