Expression of the Fc gamma receptor on Ly-1+ B lymphocytes.
The expression of IgG Fc receptor (FcR) molecules was examined on Ly-1+ B cells and B cells tumors. FcR molecules were found on a representative Ly-1+ B cell lymphoma of the pre-B and as well as of the mature cell B phenotypes. The expression of the FcR did not change on these cells during their differentiation to B cells or to antibody-secreting cells, respectively. Ly-1+ B cells were found at low frequency (approximately 2%) in the spleens of normal mice, and in the peritoneal cavity where their representation was greater. The frequency of Ly-1+ B cells declined after birth, although their numbers increased in both organs. These Ly-1+ B cells expressed the FcR molecule throughout ontogeny. Furthermore, the amount of FcR expressed on Ly-1+ B cells was similar to the levels expressed on their "conventional" (Ly-1-) B cell counterparts. The FcR was also found on Ly-1+ B cells from autoimmune mice. The significance of the expression of FcR molecules on Ly-1+ B cells is discussed.
D000818:Animals; D000950:Antigens, Ly / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000648:ultrastructure*; D002460:Cell Line; D005434:Flow Cytometry; D006128:Growth; D008221:Lymphoid Tissue / Q000166:cytology; D008223:Lymphoma / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D010641:Phenotype; D011961:Receptors, Fc / Q000032:analysis / Q000378:metabolism*; D017452:Receptors, IgG
D000950:Antigens, Ly; D011961:Receptors, Fc; D017452:Receptors, IgG