title: On the circulating form of atrial natriuretic factor.
abstract: Isolation and sequencing of IR-ANF from plasma reveal that the circulating form of ANF is a 28-amino acid peptide (Ser 99-Tyr 126) which inhibits basal aldosterone secretion from suspensions of rat zona glomerulosa cells to the same extent as synthetic Arg 101-Tyr 126. The same form (minus two N-terminal amino acids) (Arg 101-Tyr 126) has been isolated from culture media of atrial cardiocytes and sequenced. Structure activity studies of shorter, N- or C-terminally truncated versions of synthetic Arg 101-Tyr 126 show that the latter is the most potent one.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000831:Animals, Newborn; D009320:Atrial Natriuretic Factor / Q000096:biosynthesis / Q000097:blood* / Q000302:isolation & purification; D002478:Cells, Cultured; D006325:Heart Atria / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009320:Atrial Natriuretic Factor