[Morphological characteristics of the secretion of natriuretic factor by atrial cardiomyocytes in spontaneous hypertension in rats].
The results of electron microscopic studies of the synthesis and secretion of atrial natriuretic factor (ANF) in right atrial cardiomyocytes of spontaneously hypertensive rats (SHR) and the corresponding normotensive controls are presented. Enhanced secretory activity in cardiomyocytes of SHR has been revealed. The role of enhanced ANF secretion in the origin of arterial hypertension is discussed. It is suggested that enhanced ANF secretion can be attributed to increased ANF demand in BP elevation, changes in the renal function in hypertensive subjects or genetic defect in the excretory renal function in SHR.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D006321:Heart / Q000502:physiology*; D006325:Heart Atria / Q000378:metabolism / Q000648:ultrastructure; D006973:Hypertension / Q000473:pathology*; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D009320:Atrial Natriuretic Factor
Morfologicheskie osobennosti sekretsii natriĭureticheskogo faktora predserdnymi kardiomiotsitami pri spontannoĭ gipertenzii krys.