Body temperature effects of opioids in rats: intracerebroventricular administration.
A variety of opioids were injected intracerebroventricularly into unrestrained rats, and rectal temperatures were monitored over several hours. Complete dose-response data for morphine, heroin, etorphine, d- and l-ethylketazocine, d- and l-pentazocine, and d- and l-N-allylnormetazocine revealed a predominant response of hyperthermia. Only etorphine in high doses caused a pronounced decrease in body temperature. These results differed considerably from those obtained previously with subcutaneously administered opioids but can be explained in terms of a dual-receptor theory of temperature control.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D003496:Cyclazocine / Q000031:analogs & derivatives / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000494:pharmacology; D016314:Ethylketocyclazocine; D005048:Etorphine / Q000494:pharmacology; D003932:Heroin / Q000494:pharmacology; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009294:Narcotics / Q000008:administration & dosage / Q000494:pharmacology*; D010423:Pentazocine / Q000494:pharmacology; D010620:Phenazocine / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin
D004723:Endorphins; D009294:Narcotics; D009270:Naloxone; D005048:Etorphine; D016314:Ethylketocyclazocine; D001615:beta-Endorphin; D003932:Heroin; C012134:SK&F 10047; D009020:Morphine; D010620:Phenazocine; D003496:Cyclazocine; D010423:Pentazocine