title: Clinical expression of Alzheimer's disease in Down's syndrome.
abstract: Reports of the clinical manifestations of dementia in persons with Down's syndrome have been conflicting. Neuropathologic studies have been inconsistent with the clinical picture in many cases. Clarification of these issues requires longitudinal studies of patients combined with postmortem studies of brain tissue.
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000150:complications*; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged