title: Ultrastructural changes in sebaceous glands following treatment of cystic acne with isotretinoin.
abstract: Following 20 weeks of treatment with isotretinoin, sebaceous glands in patients with cystic acne shrank in size. The cells remaining in the sebaceous lobules were mainly mature lipid-filled cells, with some undifferentiated cells still present at the periphery. The ultrastructure of the glands 8 weeks after cessation of treatment was directly related to the drug dose given each patient. The larger the dose, the slower the return to pretreatment morphology. In those patients given a lower dose, most of the glands observed 2 months after treatment was stopped were similar in size to those seen prior to treatment.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D002454:Cell Differentiation / Q000187:drug effects; D003560:Cysts; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015474:Isotretinoin; D012627:Sebaceous Glands / Q000187:drug effects / Q000648:ultrastructure*; D014212:Tretinoin / Q000627:therapeutic use*
chemical_list: D014212:Tretinoin; D015474:Isotretinoin