title: Structure and analysis of the bovine atrial natriuretic peptide precursor gene.
abstract: The isolation and sequence analysis of the gene encoding the bovine atrial natriuretic peptide (ANP) precursor is described. The bovine-ANP coding sequences are located on three exons which are interrupted by two intervening sequences. Comparison of the bovine, human, rat and mouse ANP gene sequences reveals a common organization of introns and exons and a high degree of sequence homology in the 5'-flanking and coding regions. Examination of the pre-proANP amino acid sequence derived from the bovine gene with those from rat, mouse and human, indicates a high degree of sequence homology in both the amino-terminal and biologically-active carboxy-terminal ANP region. The latter region in the bovine sequence resembles its human counterpart except for a carboxy-terminal Arg-Arg dipeptide.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D001483:Base Sequence; D002417:Cattle; D004247:DNA / Q000032:analysis; D006801:Humans; D051379:Mice; D011498:Protein Precursors / Q000032:analysis / Q000235:genetics*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D011498:Protein Precursors; D009320:Atrial Natriuretic Factor; D004247:DNA