Effect of ONO-3144, a free radical scavenger, on reoxygenation injury in anoxic myocardium.
Thus, ONO-3144 treatment affords great protection against reoxygenation injury in the anoxic myocardium through the scavenging mechanism that includes .OH or closely related species of free radicals and also may inhibit thromboxane synthetase in the anoxic myocardium. We would hypothesize that free radical formation generated through the conversion of PGG2 to PGH2 should play an important role in the reoxygenation injury of the anoxic myocardium.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003402:Creatine Kinase / Q000378:metabolism; D005609:Free Radicals; D006331:Heart Diseases / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D000860:Hypoxia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D011427:Propiophenones / Q000494:pharmacology*; D051381:Rats
D005609:Free Radicals; D011427:Propiophenones; C037467:2-aminomethyl-4-tert-butyl-6-propionylphenol; D000255:Adenosine Triphosphate; D003402:Creatine Kinase; D002118:Calcium