Trinitrophenyl-derivative of urinary trypsin inhibitor: a strong antifibrinolytic agent.
A trinitrophenyl derivative of urinary trypsin inhibitor (TNP-UTI) was found to demonstrate approximately 50 times stronger antiplasmin fibrinolysis than the intact UTI. Almost no change in antitrypsin or antichymotrypsin activity occurred as a result of the UTI modification. TNP-UTI was also shown to be a strong inhibitor of nonplasmin mediated fibrinolysis.
D000933:Antifibrinolytic Agents / Q000494:pharmacology*; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D005342:Fibrinolysis / Q000187:drug effects*; D006023:Glycoproteins / Q000494:pharmacology*; D009578:Nitrobenzenes / Q000494:pharmacology*; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D014301:Trinitrobenzenes / Q000494:pharmacology*; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
D000933:Antifibrinolytic Agents; D006023:Glycoproteins; D009578:Nitrobenzenes; D014301:Trinitrobenzenes; D010959:Tissue Plasminogen Activator; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator; C028665:urinastatin