[Effect of coamide and folicobalamin on erythropoiesis during ordinary vital activities and in head-down tilt hypokinesia].
The study was performed on 41 healthy men, aged 19 to 40, who led a normal life or were exposed to short-term or long-term head-down tilts. The effectiveness of hemostimulants was determined with respect to hemoglobin, red blood cells or reticulocyte counts. Folicobalamine and coamide administration in therapeutic doses increased hemoglobin and reticulocyte blood levels in the ambulant subjects or those exposed to a 7-day head-down tilt. The effect was stable and persisted for 2-3 weeks after which the blood parameters returned to the pretest level. Folicobalamine administered at the final stage of 50-day head-down tilt facilitated partial recovery of hemoglobin during the study (which is very important) and rapid recovery after it. The objective and subjective tolerance of the drugs was good. It is therefore concluded that folicobalamine should be taken at the final stage of head-down tilt or space flight to alleviate readaptation to the normal environment.
D000328:Adult; D003035:Cobalt / Q000627:therapeutic use*; D004338:Drug Combinations; D004341:Drug Evaluation; D004906:Erythrocyte Count / Q000187:drug effects; D004920:Erythropoiesis / Q000187:drug effects*; D005492:Folic Acid / Q000627:therapeutic use*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009942:Organometallic Compounds; D011187:Posture; D013997:Time Factors; D014805:Vitamin B 12 / Q000627:therapeutic use*
D004338:Drug Combinations; D006454:Hemoglobins; D009942:Organometallic Compounds; D009536:Niacinamide; D003035:Cobalt; C012848:coamid; D005492:Folic Acid; D014805:Vitamin B 12
Vliianie koamida i folikobalamina na éritropoéz v usloviiakh obychnoĭ zhiznedeiatel'nosti i antiortostaticheskoĭ gipokinezii.