title: Twofold CuZnSOD activity suggesting homozygous submicroscopic duplication of chromosome 21 in the orangutan.
abstract: A twofold CuZnSOD activity was observed in an orangutan as compared to man and a chimpanzee. This suggests that a submicroscopic duplication of chromosome 21 (similar to those demonstrated in patients with the trisomy 21 phenotype but with a normal karyotype) has occurred in the homozygous state during evolution of the orangutan phylum. Such duplications could be important evolutionary mechanisms, together with visible chromosome rearrangements and classical gene mutations.
authors.affiliation: U 173 INSERM, Hôpital Necker-Enfants Malades, Paris.
authors.forename: J
authors.initials: J
authors.lastname: de Grouchy
authors.forename: A
authors.initials: A
authors.lastname: Nicole
authors.forename: C
authors.initials: C
authors.lastname: Cochet
authors.forename: N
authors.initials: N
authors.lastname: Créau-Goldberg
authors.forename: P M
authors.initials: PM
authors.lastname: Sinet
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004314:Down Syndrome / Q000201:enzymology; D004912:Erythrocytes / Q000201:enzymology; D015186:Hominidae / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D007621:Karyotyping; D002679:Pan troglodytes / Q000235:genetics; D011148:Pongo pygmaeus / Q000235:genetics*; D013482:Superoxide Dismutase / Q000032:analysis / Q000235:genetics*
chemical_list: D013482:Superoxide Dismutase