Some pharmacological properties and subacute and chronic toxicity of tryptamide.
Studies on Albino Swiss mice and Wistar rats have demonstrated that tryptamide is less ulcerogenic than phenylbutazone, and markedly inhibits intestinal peristalsis. Both compounds have a similar tendency to accumulate in the body. Tryptamide produces a smaller hypotension and stimulates the respiratory amplitude to a lesser extent than phenylbutazone in a vivisectional experiment. Studies on the subacute and chronic toxicity have demonstrated that tryptamide administered orally (po) and intraperitioneally (ip) for 3 weeks, and orally for 3 months neither affects the body weight gain or the mass of internal organs, nor changes the locomotor activity; only in rats it disturbs the motor coordination. After ip administration tryptamide shows a moderate depressant effect on the bone marrow, evidenced by a decline in the blood hemoglobin content and the number of erythrocytes and blood platelets. As those changes were more pronounced after a 3-week than a 3-month administration, the observed effects are apparently reversible.
Kleinrok
Z
Z
Department of Pharmacology, Medical Academy, Lublin, Poland.
Sieklucka
M
M
Rajtar
G
G
Czuczwar
S J
SJ
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004562:Electrocardiography; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D007422:Intestines / Q000187:drug effects / Q000502:physiology; D007928:Lethal Dose 50; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D009929:Organ Size / Q000187:drug effects; D010528:Peristalsis; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects; D000637:Transaminases / Q000097:blood; D014363:Tryptamines / Q000494:pharmacology* / Q000633:toxicity; D014599:Uterus / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014363:Tryptamines; D009536:Niacinamide; C057564:tryptamide; D000637:Transaminases