title: Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro.
abstract: Human small cell lung carcinoma (SCLC) cells have been shown to contain significant levels of a bombesin-immunoreactive peptide. The 27-amino acid peptide, gastrin releasing peptide (GRP), has recently been shown to be responsible for the bombesin-like immunoreactivity found in SCLC cells. Among four lung cancer cell lines examined in vitro, GRP exhibited mitogenic activity for two SCLC subtypes, but not for a squamous carcinoma or adenocarcinoma lung cell line. The mitogenicity of the GRP molecule has been isolated to the carboxyterminal fragment, designated GRP 14-27, which is in part homologous to bombesin. The aminoterminal fragment, GRP 1-16, is no homologous to bombesin and exhibits no mitogenic activity. Thus, GRP may be an important growth regulating or autocrine factor in human SCLC.
authors.forename: S
authors.initials: S
authors.lastname: Weber
authors.forename: J E
authors.initials: JE
authors.lastname: Zuckerman
authors.forename: D G
authors.initials: DG
authors.lastname: Bostwick
authors.forename: K G
authors.initials: KG
authors.lastname: Bensch
authors.forename: B I
authors.initials: BI
authors.lastname: Sikic
authors.forename: T A
authors.initials: TA
authors.lastname: Raffin
mesh_terms: D018288:Carcinoma, Small Cell / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D002452:Cell Count; D019886:Gastrin-Releasing Peptide; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008934:Mitogens; D010455:Peptides / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
chemical_list: D008934:Mitogens; D010455:Peptides; D014316:Tritium; D019886:Gastrin-Releasing Peptide; D013936:Thymidine