Effect of lipoxygenase metabolites of arachidonic acid on proliferation of human T cells and T cell subsets.
The lipoxygenase products LTB4 and 15 HPETE have been reported to stimulate T suppressor cell function and also to inhibit [3H]thymidine incorporation into mitogen-stimulated T cells. This present report documents that although these compounds do indeed inhibit [3H]thymidine incorporation into unfractionated T cells, they significantly enhance [3H]thymidine incorporation into T cell preparation enriched for cells bearing the cytotoxic suppressor cell phenotype identified by the OKT8 monoclonal antibody. The mitogen response of T cells enriched for OKT4+ helper-inducer cells is inhibited in manner similar to the response of unfractionated T cells. Thus, LTB4 and 15 HPETE stimulate both the function and the proliferation of the cytotoxic-suppressor T cell subset.
Gualde
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N
Atluru
D
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Goodwin
J S
JS
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism* / Q000494:pharmacology*; D015232:Dinoprostone; D006801:Humans; D007975:Leukotriene B4 / Q000494:pharmacology*; D015289:Leukotrienes; D008054:Lipid Peroxides / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D010641:Phenotype; D011458:Prostaglandins E / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology* / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013936:Thymidine / Q000378:metabolism
D001095:Arachidonic Acids; D015289:Leukotrienes; D008054:Lipid Peroxides; D011458:Prostaglandins E; D007975:Leukotriene B4; D016718:Arachidonic Acid; C025086:15-hydroperoxy-5,8,11,13-eicosatetraenoic acid; D015232:Dinoprostone; D013936:Thymidine