title: Sneddon's disease presenting with visual loss and dementia.
abstract: A 51-year-old woman with Sneddon's disease presented with transient right hemifield loss of vision and transient right-sided weakness. Over the preceding decade she had experienced a slow decline in mental function. She also had hypertension, migraine, and a mixed seizure disorder. She had skin changes typical for generalized livedo reticularis but she did not have Raynaud's phenomenon or winter ulcerations. Her disease was not understood until the stroke-related symptoms were associated with the skin abnormalities. We review the neuro-ophthalmic manifestations of Sneddon's disease and add data from our case to the growing body of fact that suggests that Sneddon's disease may be an immunologically mediated vasculopathy.
authors.affiliation: Department of Ophthalmology, University of Colorado School of Medicine, Denver.
authors.forename: W B
authors.initials: WB
authors.lastname: Wilson
authors.forename: D B
authors.initials: DB
authors.lastname: Smith
authors.forename: R R
authors.initials: RR
authors.lastname: Wright
authors.forename: C E
authors.initials: CE
authors.lastname: Seibert
mesh_terms: D002561:Cerebrovascular Disorders / Q000150:complications*; D003704:Dementia / Q000209:etiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012871:Skin Diseases / Q000150:complications; D013577:Syndrome; D014057:Tomography, X-Ray Computed; D014786:Vision Disorders / Q000209:etiology*; D014794:Visual Fields