A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen.
A human gene (LAR) that hybridizes to mouse leukocyte common antigen cDNA under relaxed hybridization conditions was isolated. The LAR gene is expressed in a broad range of cells, including T lymphocytes, kidney, and prostate cells. The structure of the protein encoded by the LAR gene was deduced by determining the nucleotide sequences of a 7.7-kb LAR cDNA. The putative LAR protein is composed of a 1,234 amino acid extracellular region, a 24 amino acid transmembrane segment, and a 623 amino acid cytoplasmic region. The cytoplasmic region contains two homologous domains that have extensive sequence similarity to the cytoplasmic region of the leukocyte common antigens. The NH2-terminal region of the extracellular segment of the LAR protein contains three tandem Ig-like domains and nine non-Ig-like domains. Among the known Ig-like proteins, the LAR protein has the highest degree of similarity to neural-cell adhesion molecule. The non-Ig-like domains of the LAR protein are also similar to the non-Ig-like domains of neural-cell adhesion molecule.
Streuli
M
M
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Krueger
N X
NX
Hall
L R
LR
Schlossman
S F
SF
Saito
H
H
D000595:Amino Acid Sequence; D000818:Animals; D000943:Antigens, Differentiation / Q000235:genetics*; D015152:Blotting, Northern; D003593:Cytoplasm; D005796:Genes; D005803:Genes, Immunoglobulin; D006649:Histocompatibility Antigens / Q000235:genetics*; D006801:Humans; D017493:Leukocyte Common Antigens; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
D000943:Antigens, Differentiation; D006649:Histocompatibility Antigens; D017493:Leukocyte Common Antigens