Effect of long-term treatment with celiprolol on pulmonary function in a group of mild hypertensive asthmatics.
Previous studies have shown that single dose or short-term administration of celiprolol does not impair pulmonary function in patients with asthma. The long-term effects of celiprolol and chlorthalidone on respiratory function in mild hypertensive asthmatic patients were compared. Following a 1-month placebo washout period, five patients were randomized to 3 months of treatment with celiprolol, and four patients were treated with chlorthalidone. This double-blind study was followed by a 12-month open trial in 13 asthmatics. Forced expiratory volume at the first second of expiration (FEV1) remained unchanged throughout the 12-month treatment period. This finding is of interest since a spontaneous decrease in FEV1 of 20 ml/year has been observed in recent surveys of asthmatic patients. No changes in peak expiratory flow rate or maximum expiratory flow at 50% of vital capacity were observed during the study, but measurements of FEV1 before and 2 h after drug administration indicated that celiprolol had no direct bronchodilating effect. The responsiveness to inhaled salbutamol was unaltered during the 12-month trial period, demonstrating that celiprolol does not block the beta 2-adrenoceptors on bronchial smooth muscle. Our results indicate that celiprolol is a safe long-term treatment for hypertension in asthmatic patients. Nevertheless, a survey of a large number of patients may be useful in order to detect individuals at risk, since sensitivity to beta-blockade may vary between patients.
Clauzel
A M
AM
Hopital l'Aiguelongue, CHU, Montpellier, France.
Jean
T
T
Etienne
R
R
Visier
S
S
Michel
F
F
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001249:Asthma / Q000150:complications* / Q000503:physiopathology; D017272:Celiprolol; D002752:Chlorthalidone / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000009:adverse effects / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D011412:Propanolamines; D017272:Celiprolol; D002752:Chlorthalidone