The effect of lithium in vitro and in vivo on dopamine-sensitive adenylate cyclase activity in dopaminergic areas of the rat brain.
Lithium (5 and 20 mM) was found to inhibit the dopamine-stimulated cyclic AMP formation in homogenates from rat striatum and olfactory tubercle, leaving basal and fluoride-stimulated activities unaffected. The inhibition of dopamine-stimulated adenylate cyclase was non-competitive and dose-dependent. However, in rats treated with lithium for four weeks, no alterations were found in basal, fluoride- and dopamine-stimulated adenylate cyclase activities. It is suggested that lithium interferes with hormonal stimulation of adenylate cyclase activity by an interaction with the process regulating the transfer of the receptor-hormone stimulus to the adenylate cyclase enzyme.
Geisler
A
A
Klysner
R
R
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D003342:Corpus Striatum / Q000201:enzymology; D000242:Cyclic AMP / Q000096:biosynthesis; D004298:Dopamine / Q000502:physiology*; D066298:In Vitro Techniques; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009830:Olfactory Bulb / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000494:pharmacology
D012969:Sodium Fluoride; D008094:Lithium; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D004298:Dopamine