[Transformation by SV 40 virus sensitizes fibroblasts of human skin to the lytic action of H-1 parvovirus].
Human skin fibroblasts which are naturally resistant to Parvovirus H-1 can be lysed by this virus after SV40 transformation. This observation raises the possibility that oncosuppression by Parvovirus involves a direct oncolytic effect.
de Foresta
F
F
Deleys-Hertoghs
J
J
Cornelis
J
J
Klein
B
B
Rommelaere
J
J
D000818:Animals; D002455:Cell Division; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D005347:Fibroblasts / Q000382:microbiology; D006801:Humans; D010321:Parvoviridae / Q000472:pathogenicity*; D013539:Simian virus 40 / Q000502:physiology*; D012867:Skin / Q000382:microbiology; D014762:Viral Interference
La transformation par le virus SV40 sensibilise les fibroblastes de peau humaine à l'action lytique du parvovirus H-1.