Role of Langerhans cells in the infection of the guinea-pig epidermis with foot-and-mouth disease virus.
In guinea-pig infected with foot-and-mouth disease virus (FMDV), Langerhans cells in the foot pads increase in number and show viral antigens 24 hours post-inoculation, preceding appearance of virus in epithelial cells and vesiculation. This observation suggests that Langerhans cells may be engaged in virus transport from the blood to the non vascularized epidermis.
di Girolamo
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Salas
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D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D005537:Aphthovirus / Q000276:immunology*; D002452:Cell Count; D004817:Epidermis / Q000276:immunology / Q000382:microbiology; D005455:Fluorescent Antibody Technique; D005536:Foot-and-Mouth Disease / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D006168:Guinea Pigs; D007801:Langerhans Cells / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
D000956:Antigens, Viral