Selective induction of T-cell subsets by antibodies to the T-cell antigen receptor and to the subset-specific differentiation antigens CD8 and CD4.
This report shows that small, resting T lymphocytes from mouse and man can be activated to proliferation and function by submitogenic concentrations of antibodies to T-cell antigen receptor in combination with antibodies to either CD8 or CD4. The combined antibodies can be applied either in solid phase condition or as soluble dimeric heteroconjugates. Activation is more efficient than by high concentrations of anti-T-cell-receptor antibody alone. Most importantly, activation is subset-specific such that the antibody to CD8/CD4 determines which T-cell subset will be induced.
Eichmann
K
K
Max-Planck-Institut für Immunbiologie, Freiburg, FRG.
Emmrich
F
F
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000906:Antibodies; D000945:Antigens, Differentiation, T-Lymphocyte; D011948:Receptors, Antigen, T-Cell