title: A double-blind crossover comparison of lidamidine, loperamide and placebo for the control of chronic diarrhoea.
abstract: Fourteen patients with chronic diarrhoea, but no evidence of active organic disease, completed a double-blind crossover comparison of the anti-diarrhoeal effects of loperamide, placebo and the clonidine analogue, lidamidine. Failure of diarrhoea control led to early withdrawals from seven placebo- and six lidamidine-treatment periods, but there was only one early withdrawal during treatment with loperamide. Loperamide was found to be superior to lidamidine or placebo for the control of stool consistency in patients with chronic diarrhoea.
authors.affiliation: Academic Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
authors.forename: M C
authors.initials: MC
authors.lastname: Allison
authors.forename: J
authors.initials: J
authors.lastname: Sercombe
authors.forename: R E
authors.initials: RE
authors.lastname: Pounder
mesh_terms: D000328:Adult; D000368:Aged; D000930:Antidiarrheals / Q000627:therapeutic use*; D002908:Chronic Disease; D003967:Diarrhea / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008139:Loperamide / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010671:Phenylurea Compounds / Q000627:therapeutic use*
chemical_list: D000930:Antidiarrheals; D010671:Phenylurea Compounds; D008139:Loperamide; C020918:lidamidine