[Cyclic nucleotide levels in the regenerating liver of rats following irradiation and protection by serotonin].
Changes in cAMP and cGMP levels after X-irradiation and radioprotective treatment with serotonin were studied using a model of impulse inhibition and repair of transcription, translation and replication by cycloheximide in rat hepatocytes in vivo. Irradiation was shown to inhibit the cyclic nucleotide synthesis. Serotonin increased the contents of cAMP and cGMP maintaining their elevated level after X-irradiation.
Aslamova
L I
LI
Blium
Ia B
IaB
Tsudzevich
B A
BA
Kucherenko
N E
NE
D000818:Animals; D000242:Cyclic AMP / Q000528:radiation effects*; D006152:Cyclic GMP / Q000528:radiation effects*; D003513:Cycloheximide / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D008115:Liver Regeneration / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D011837:Radiation-Protective Agents; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013997:Time Factors
D011837:Radiation-Protective Agents; D012701:Serotonin; D003513:Cycloheximide; D000242:Cyclic AMP; D006152:Cyclic GMP
Urovni tsiklicheskikh nukleotidov v proliferiruiushcheĭ pecheni krys posle oblucheniia i v usloviiakh zashchity serotoninom.