Antiviral activity of CP-20,961 against herpes simplex viruses in vitro.
The antiherpesvirus activity of CP-20,961 [N,N-dioctadecyl-N',N'-bis (2-hydroxyethyl) propanediamine, or Avridine] was investigated in cultured guinea pig embryo (GPE) cells. Plaque formation of herpes simplex virus type 1 (HSV1) and type 2 (HSV2) was inhibited, but vesicular stomatitis virus replication was not inhibited, in GPE cells treated with CP-20,961 before infection. The ID50 concentration of CP-20,961 for HSV was about 50 micrograms/ml for 3-4 days of pretreatment. After virus adsorption and penetration, the same concentration of CP-20,961 had no effect on HSV plaque formation. The compound showed no detergent-like properties nor did it elicit any detectable interferon activity. Thus, the anti-HSV activity of CP-20,961 appeared to be associated with blocking the adsorption or penetration of the virus or both.
Zheng
Z M
ZM
Mayo
D R
DR
Fong
C K
CK
Winship
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Hsiung
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GD
D000212:Acyclovir / Q000494:pharmacology; D000818:Animals; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives / Q000494:pharmacology; D002478:Cells, Cultured; D003959:Diamines / Q000494:pharmacology*; D004622:Embryo, Mammalian; D017245:Foscarnet; D006168:Guinea Pigs; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D011817:Rabbits; D018139:Simplexvirus / Q000187:drug effects*
D003959:Diamines; C020235:brivudine; D017245:Foscarnet; D001973:Bromodeoxyuridine; D010746:Phosphonoacetic Acid; C006270:avridine; D000212:Acyclovir