title: Cyclosporin for Crohn's disease.
abstract: Eight patients with active uncomplicated Crohn's disease, who were resistant to or intolerant of conventional treatment, were treated for 6 weeks with oral cyclosporin (mean dose 8.2 mg kg-1 day-1). Seven of the eight patients responded to treatment with cyclosporin by symptomatic improvement, weight gain and a return of serum C-reactive protein concentration towards normal. All patients relapsed on stopping cyclosporin. No serious side-effects were encountered. This favourable early experience justifies further trials using cyclosporin for active Crohn's disease.
authors.affiliation: Academic Department of Medicine, Royal Free Hospital, London, UK.
authors.forename: M C
authors.initials: MC
authors.lastname: Allison
authors.forename: R E
authors.initials: RE
authors.lastname: Pounder
mesh_terms: D000293:Adolescent; D000328:Adult; D003424:Crohn Disease / Q000188:drug therapy*; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D016572:Cyclosporine