[Strategies for the detection of DNA polymorphism in human populations].
We develop here several models concerning strategies for detection of restriction polymorphisms in humans. These different strategies concern the numbers of individuals to test in a DNA collection, the nature of restriction enzyme to utilize, and the length of the probes. For enzyme utilization different strategies are based on (i) the nature of the restriction site; (ii) the mean length of restriction fragments obtained; (iii) the methylated cytosine characteristics in the CG doublets. Each of these approaches are tested in experimental situations.
Bastié-Sigeac
F
F
Mornet
E
E
Lucotte
G
G
D004247:DNA / Q000235:genetics*; D004262:DNA Restriction Enzymes / Q000502:physiology*; D005260:Female; D005787:Gene Frequency; D006580:Genetic Carrier Screening; D005828:Genetics, Population; D006801:Humans; D008297:Male; D009154:Mutation; D009693:Nucleic Acid Hybridization; D010297:Paris; D011110:Polymorphism, Genetic
D004247:DNA; D004262:DNA Restriction Enzymes
Stratégies de détection des polymorphismes de l'ADN dans les populations humaines.