The missense errors in protein can be controlled by selective synonymous codon usage at the level of transcription.
In the cases of the 6-fold degenerate residues and the stop signal, selective codon usage at the level of transcription can account for a 10-20% variation in their mistranslation rate. For all other residues, the mistranslation rate is dependent upon the degree of degeneracy only, but not upon the pattern of synonymous codon usage.
Konopka
A K
AK
Brendel
V
V
D000818:Animals; D001221:Aspartate Carbamoyltransferase; D001426:Bacterial Proteins / Q000032:analysis / Q000235:genetics; D001483:Base Sequence; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); D003062:Codon; D004080:Dihydroorotase; D008433:Mathematics; D009097:Multienzyme Complexes; D011506:Proteins / Q000032:analysis / Q000235:genetics; D012333:RNA, Messenger; D014158:Transcription, Genetic; D014764:Viral Proteins / Q000032:analysis / Q000235:genetics
D001426:Bacterial Proteins; C033626:CAD trifunctional enzyme; D003062:Codon; D009097:Multienzyme Complexes; D011506:Proteins; D012333:RNA, Messenger; D014764:Viral Proteins; D001221:Aspartate Carbamoyltransferase; D004080:Dihydroorotase; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)