title: High dose nicotinamide in the treatment of necrobiosis lipoidica.
abstract: An open study of high dose nicotinamide in the treatment of 15 patients with necrobiosis lipoidica is reported. Of 13 patients who remained on treatment for more than 1 month, eight improved. Improvement took the form of a decrease in pain and soreness, a decrease in erythema and the healing of ulcers if present, although the skin did not return completely to normal in any patient. There were no significant side-effects, particularly with respect to diabetic control, an important finding as lesions tended to relapse if treatment was stopped.
authors.affiliation: Department of Dermatology, Bristol Royal Infirmary, U.K.
authors.forename: S
authors.initials: S
authors.lastname: Handfield-Jones
authors.forename: S
authors.initials: S
authors.lastname: Jones
authors.forename: R
authors.initials: R
authors.lastname: Peachey
mesh_terms: D000328:Adult; D000368:Aged; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009335:Necrobiosis Lipoidica / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D009536:Niacinamide / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D009536:Niacinamide