Erythromycin 2 percent gel in the treatment of acne vulgaris.
A gel formulation of erythromycin 2 percent was compared with its vehicle in a double-blind multicenter study involving patients with mild to moderate acne vulgaris. In an analysis of 187 patients treated twice daily for 8 weeks, erythromycin 2 percent gel proved to be significantly more effective than vehicle in reducing the numbers of both inflammatory and noninflammatory lesions. After 8 weeks, 60 percent of erythromycin-treated patients had good or excellent responses compared with 36 percent of those using vehicle (p = 0.001); the lesions in two patients using erythromycin were completely cleared. The majority of patients had a favorable impression of the cosmetic characteristics of the gel formulation.
Pochi
P E
PE
Department of Dermatology, Boston University Medical Center, Massachusetts.
Bagatell
F K
FK
Ellis
C N
CN
Stoughton
R B
RB
Whitmore
C G
CG
Saatjian
G D
GD
Sefton
J
J
D000152:Acne Vulgaris / Q000188:drug therapy*; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D003258:Consumer Behavior; D004917:Erythromycin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005148:Facial Dermatoses / Q000188:drug therapy; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged
D005782:Gels; D004917:Erythromycin