title: A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle.
abstract: The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. Adrenaline, a beta-adrenergic receptor effector, forskolin, a direct adenylate cyclase activator and fluphenazine, a calmodulin inhibitor, all produced an increase in the intracellular level of cyclic AMP and a concomitant inhibition of lactose production. These results suggest a role for adrenaline and calmodulin in modulating cyclic AMP levels in mammary tissue during the lactogenic cycle.
authors.forename: A
authors.initials: A
authors.lastname: Muñoz
authors.forename: S
authors.initials: S
authors.lastname: Lavandero
authors.forename: E
authors.initials: E
authors.lastname: Donoso
authors.forename: J
authors.initials: J
authors.lastname: Puente
authors.forename: M
authors.initials: M
authors.lastname: Sapag-Hagar
mesh_terms: D000818:Animals; D002147:Calmodulin / Q000494:pharmacology*; D005576:Colforsin; D000242:Cyclic AMP / Q000378:metabolism*; D004224:Diterpenes / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D005476:Fluphenazine / Q000494:pharmacology; D007774:Lactation; D007785:Lactose / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000378:metabolism; D011247:Pregnancy; D051381:Rats
chemical_list: D002147:Calmodulin; D004224:Diterpenes; D005576:Colforsin; D000242:Cyclic AMP; D007785:Lactose; D005476:Fluphenazine; D004837:Epinephrine