title: [Interrelations of NAD and adenosine transformation in the rat liver].
abstract: The interrelationship of NAD and adenosine (inosine) conversions in the rat liver is investigated. The ratio of products of NAD+ conversions (ADP-ribose, inosine, hypoxanthine and ribose phosphates) are established. AMP and adenosine are not detected, which indicates an availability of different activities of the corresponding enzymes. It is shown that under conditions of the high inorganic phosphate concentration (33 mM) ribose-1-phosphate, formed in the purine nucleoside phosphorylase reaction, is accumulated due to the phosphoribomutase inhibition, but in the presence of NAD+ the utilization of ribose phosphate increases significantly. Nicotinamide inhibits the NAD+-glycohydrolase reaction in the system containing 33 mM phosphate, NAD+ and adenosine and simultaneously it lowers the utilization of ribose.
authors.forename: I D
authors.initials: ID
authors.lastname: Golovatskiĭ
authors.forename: A A
authors.initials: AA
authors.lastname: Tsegel'skiĭ
mesh_terms: D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D009243:NAD / Q000378:metabolism*; D009536:Niacinamide / Q000494:pharmacology; D010084:Oxidation-Reduction; D051381:Rats; D012266:Ribose / Q000378:metabolism
chemical_list: D009243:NAD; D009536:Niacinamide; D012266:Ribose; D000241:Adenosine
vernacular_title: Vzaimovliianie prevrashcheniĭ NAD i adenozina v pecheni krys.