Cellular requirements of IgE-antibody regulation.
The low affinity receptor for IgE (Fc epsilon RII), which is identical to CD 23 has been recently implicated in a variety of functions. It appears as an early stage specific marker in the ontogeny of the IgM-bearing B cell. In humans the CD 23 is also exposed on T-cells in patients with elevated IgE, while in rodents Fc epsilon RII seems to be mainly present on T-lymphocytes. Fc epsilon RII can also be detected on macrophages, eosinophils and platelets. Activation of these cells induces an amplification of the inflammatory response. It is currently suggested that IgE-binding molecules, which are related to CD 23, modulate IgE synthesis according to their degree of glycosylation. Evidence has been provided recently that interleukin 4 induces the expression of Fc epsilon RII (CD23). The action of interleukins, IgE binding factors and cytokines on the complex events of IgE-induction and synthesis are currently studied.
König
W
W
Med. Mikrobiologie und Immunologie, Ruhr-Universität Bochum, Federal Republic of Germany.
Pfeil
P
P
Hofmann
U
U
Bujanowski-Weber
J
J
Knöller
I
I
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000937:Antigen-Antibody Reactions; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D005786:Gene Expression Regulation; D006031:Glycosylation; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000276:immunology*; D007378:Interleukins / Q000494:pharmacology; D008222:Lymphokines / Q000276:immunology; D051379:Mice; D009349:Nematode Infections / Q000276:immunology; D009559:Nippostrongylus; D029584:Prostatic Secretory Proteins; D051381:Rats; D011961:Receptors, Fc / Q000276:immunology*; D017455:Receptors, IgE; D013601:T-Lymphocytes / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000944:Antigens, Differentiation, B-Lymphocyte; D007378:Interleukins; D008222:Lymphokines; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc; D017455:Receptors, IgE; C026408:anti-IgE antibodies; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors; D007073:Immunoglobulin E