title: Elevated spontaneous mutation rate in SV40-transformed Werner syndrome fibroblast cell lines.
abstract: Spontaneous mutation rates of the cells from patients with Werner syndrome were examined, and we found that the spontaneous mutation rates at the hypoxanthine-guanine phosphoribosyltransferase locus in SV40-transformed Werner syndrome cell lines were markedly elevated, compared to those in SV40-transformed normal control cell lines. Our results suggest that Werner syndrome is a mutation mutant.
authors.forename: K
authors.initials: K
authors.lastname: Fukuchi
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: J
authors.initials: J
authors.lastname: Nakura
authors.forename: Y
authors.initials: Y
authors.lastname: Kumahara
authors.forename: T
authors.initials: T
authors.lastname: Uchida
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
mesh_terms: D000328:Adult; D002460:Cell Line; D002472:Cell Transformation, Viral; D005260:Female; D005347:Fibroblasts / Q000201:enzymology; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009154:Mutation; D013539:Simian virus 40; D014898:Werner Syndrome / Q000235:genetics*
chemical_list: D007041:Hypoxanthine Phosphoribosyltransferase