[Interleukin 2 inhibitor activity in blood serum].
Normal murine, horse and human sera inhibit the proliferation of thymocytes, T blast cells and cloned cytotoxic T lymphocytes in vitro dose dependently. This effect is specific to IL 2-dependent cell proliferations. The inhibitory activity does not decrease the binding of IL 2 to its receptor, but inhibits the IL 2 receptor expression dose dependently. An excess of purified IL 2 can overcome the inhibition of IL 2-dependent cell proliferation. Using gel filtration, we have found the inhibitory activity in the region of 80,000 MW. This inhibitory activity is precipitated by 50% saturated ammonium sulfate. The species-specificity of this inhibitor in serum is very low. The IL 2-inhibitor is discussed as a part of natural immunoregulation and as a hint for activation of the immune system.
Friemel
H
H
Institut für Immunologie, Bereich Medizin der Wilhelm-Pieck-Universität Rostock.
Nausch
M
M
Werner
H
H
D000818:Animals; D006736:Horses; D006801:Humans; D007376:Interleukin-2 / Q000037:antagonists & inhibitors*; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000097:blood*; D051379:Mice; D008808:Mice, Inbred CBA; D008819:Mice, Nude; D008970:Molecular Weight; D011971:Receptors, Immunologic / Q000378:metabolism; D015375:Receptors, Interleukin-2; D013045:Species Specificity
D007376:Interleukin-2; D008222:Lymphokines; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; C046147:interleukin 2 inhibitor
IL 2-Inhibitor-Aktivität im Blutserum.