[Structural and functional state of the erythrocyte membrane in experimental carcinogenesis].
Structural and functional state of erythrocyte surface membrane was studied in C3H and C57B1/6 mice as well as in Wistar rats after 20-methylcholanthrene administration. It is shown that mice genetically susceptible to tumor growth as compared with mice resistant to carcinogenesis are characterized by an increased level of spinous erythrocytes (echinocytosis), higher membrane microviscosity and a tendency to increase polarity of their membrane lipid bilayer in the region of hydrophobic spine sound localization. The growth of chemically induced sarcomas was also accompanied by echinocytosis but with opposite changes in microviscosity and polarity of the erythrocyte membrane lipid bilayer. It is supposed that spinous erythrocyte transformation induced by different causes is based on different physicochemical factors.
Tereshchenko
I P
IP
Kashulina
A P
AP
Aleksandrova
L M
LM
Rudenko
T S
TS
Zhukova
N I
NI
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000097:blood*; D004198:Disease Susceptibility; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000502:physiology / Q000648:ultrastructure*; D004913:Erythrocytes, Abnormal / Q000502:physiology / Q000648:ultrastructure; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000097:blood* / Q000139:chemically induced; D013499:Surface Properties
D008748:Methylcholanthrene; D000251:Adenosine Triphosphatases
Strukturno-funktsional'noe sostoianie membrany éritrotsitov pri éksperimental'nom kantserogeneze.