In vivo evaluation of mu, delta and kappa opioid receptor agonists on spinal 5-HT metabolism in the rat.
Morphine was found to elevate spinal dorsal horn 5-hydroxyindole acetic acid (5-HIAA) in a dose-dependent manner. These actions also were naloxone-reversible. In marked contrast other mu, delta and kappa opioid receptor agonists did not alter 5-HIAA levels. These studies clearly indicate that descending spinal 5-hydroxytryptamine (5-HT) pathways are not essential for opiate analgesia.
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D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D008297:Male; D009020:Morphine / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology*; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D012701:Serotonin / Q000502:physiology*; D013116:Spinal Cord / Q000503:physiopathology*
D000700:Analgesics; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D012701:Serotonin; D009020:Morphine