Chronic alpha-adrenoceptor blockade with trimazosin in congestive heart failure.
We evaluated chronic adjunctive alpha-1 receptor blockade with trimazosin in congestive heart failure. This agent produced hemodynamic effects consistent with venodilation (reduced left ventricular volume and filling pressure with increased left ventricular ejection fraction), but only during exercise. Resting hemodynamic parameters and exercise duration were not significantly altered by chronic alpha-1 receptor blockade.
Kirlin
P C
PC
Das
S
S
Pitt
B
B
D002908:Chronic Disease; D005080:Exercise Test; D006333:Heart Failure / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use*
D010879:Piperazines; D011942:Receptors, Adrenergic, alpha; D014665:Vasodilator Agents; C005185:trimazosin