Reduced anaerobic glycolysis in oral contraceptive users.
Oral contraceptives containing combinations of estrogens and progestogens are known to impair glucose tolerance. The biochemical mechanisms underlying this lesion are speculative. In the present study women treated with OC for periods exceeding 10 cycles showed significant reduction in the activity of the key glycolytic enzyme phosphofructokinase (40%) and the levels of lactate (42%) in the erythrocytes compared to controls. These observations in women are analogous to those made earlier in female rats.
Vijayalakshmi
R
R
National Institute of Nutrition, Indian Council of Medical Research, Hyderabad.
Bamji
M S
MS
Ramalakshmi
B A
BA
D000328:Adult; D000693:Anaerobiosis; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005635:Fructosediphosphates / Q000097:blood; D005636:Fructosephosphates / Q000097:blood; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates / Q000097:blood; D006019:Glycolysis; D006801:Humans; D007773:Lactates / Q000097:blood; D009644:Norgestrel / Q000008:administration & dosage / Q000378:metabolism*; D010732:Phosphofructokinase-1 / Q000378:metabolism; D011773:Pyruvates / Q000097:blood; D012959:Socioeconomic Factors
D003277:Contraceptives, Oral, Combined; D005635:Fructosediphosphates; D005636:Fructosephosphates; D005958:Glucosephosphates; D007773:Lactates; D011773:Pyruvates; D009644:Norgestrel; D004997:Ethinyl Estradiol; D019298:Glucose-6-Phosphate; C027618:fructose-6-phosphate; D010732:Phosphofructokinase-1; C029063:fructose-1,6-diphosphate