title: Human monoclonal antibodies neutralizing varicella-zoster virus.
abstract: Hybridomas secreting human monoclonal antibodies to varicella-zoster virus were produced by fusing B cells of a patient recovering from acute varicella infection with a human-mouse cell line. Two hybrid lines have continued to secrete IgG1, one with kappa and the other with lambda chains, for at least 12 months. Each antibody neutralizes virus infectivity between 1-5 micrograms of partially purified immunoglobulin/ml, each shows a different pattern of immunofluorescent staining of virus-infected cells, and one identifies three viral proteins with molecular weights of 60,000, 95,000, and 97,000.
authors.forename: S K
authors.initials: SK
authors.lastname: Foung
authors.forename: S
authors.initials: S
authors.lastname: Perkins
authors.forename: C
authors.initials: C
authors.lastname: Koropchak
authors.forename: D M
authors.initials: DM
authors.lastname: Fishwild
authors.forename: A E
authors.initials: AE
authors.lastname: Wittek
authors.forename: E G
authors.initials: EG
authors.lastname: Engleman
authors.forename: F C
authors.initials: FC
authors.lastname: Grumet
authors.forename: A M
authors.initials: AM
authors.lastname: Arvin
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D006562:Herpes Zoster / Q000276:immunology / Q000517:prevention & control; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D051379:Mice; D008970:Molecular Weight; D009500:Neutralization Tests; D014764:Viral Proteins / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D007074:Immunoglobulin G; D014764:Viral Proteins