Antiviral activity of coumermycin: identification of resistant and sensitive retrovirus strains.
The effect of Coumermycin (CA1) on the replication of different ecotropic retroviruses was studied. Most strains showed reductions in infectivity of less than ten fold, while two strains demonstrated a marked sensitivity to the drug. The isolation of one resistant strain could suggest a specific CA1 antiviral activity.
Varnier
O E
OE
Muratore
O
O
Raffanti
S P
SP
Schito
G C
GC
D049933:Aminocoumarins; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002460:Cell Line; D003374:Coumarins / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D009052:Leukemia Virus, Murine / Q000187:drug effects* / Q000254:growth & development; D051379:Mice; D014779:Virus Replication / Q000187:drug effects
D049933:Aminocoumarins; D000900:Anti-Bacterial Agents; D003374:Coumarins; C004628:coumermycin