Effects of tifluadom on passive avoidance behaviour in DBA/2 mice.
The effects of the selective opiate kappa-receptor agonist tifluadom on memory were investigated in a passive avoidance task in 3 sets of experiments carried out with DBA/2 (DBA) mice both familiarized and unfamiliarized with the apparatus. In a first set of experiments, tifluadom (1.0 or 2.5, but not 0.5 mg/kg) administration immediately after training impaired retention performance of non-familiarized mice. This impairment was still evident when the drug was injected 15 or 30, but not 60 min after training. A second set of experiments was carried out with mice familiarized with the apparatus. Tifluadom was less effective in impairing memory in this group of animals, as compared with non-familiarized mice. Finally, in a third set of experiments, carried out with non-familiarized mice, a 15 min immobilization stress, which was ineffective when administered alone, enhanced the effects of tifluadom (1.0 mg/kg). The results are discussed in terms of attenuation of emotionality, resulting in impaired retention, following post-training opiate administration.
Pavone
F
F
Castellano
C
C
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001569:Benzodiazepines / Q000494:pharmacology*; D004597:Electroshock; D008027:Light; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008811:Mice, Inbred DBA; D011930:Reaction Time / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects*; D017473:Receptors, Opioid, kappa; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000503:physiopathology
D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D001569:Benzodiazepines; C035470:tifluadom