Estradiol modulation of alpha 2-noradrenergic receptors in guinea pig brain assessed by tritium-sensitive film autoradiography.
In this experiment, we examined the influence of estradiol on alpha 2-noradrenergic receptor binding in the female guinea pig brain with tritium-sensitive film autoradiography. Treatment of ovariectomized guinea pigs with estradiol increased alpha 2-receptor binding in regions of the preoptic area and decreased binding in the ventromedial nucleus of the hypothalamus. There was no effect of estradiol on alpha 2-receptor concentrations in other estradiol concentrating regions or in brain areas which do not concentrate estradiol.
Johnson
A E
AE
Nock
B
B
McEwen
B
B
Feder
H H
HH
D000818:Animals; D001345:Autoradiography; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000378:metabolism
D011942:Receptors, Adrenergic, alpha; D004958:Estradiol