The reactivity of pulsed cytochrome c oxidase toward carbon monoxide.
When pulsed cytochrome c oxidase is exposed to carbon monoxide in the absence of oxygen the enzyme is converted quickly to its CO-associated mixed valence state. The half-time for this reaction at 0 degree C is about 4 min. This is about 100 times faster than a similar reaction which begins with the resting form of the enzyme. The possible significance of this reaction in understanding the pulsed/resting phenomenon and the carbon monoxide oxygenase reactions of cytochrome oxidase is discussed.
Morgan
J E
JE
Blair
D F
DF
Chan
S I
SI
D000818:Animals; D002248:Carbon Monoxide / Q000378:metabolism*; D002417:Cattle; D003576:Electron Transport Complex IV / Q000378:metabolism*; D004789:Enzyme Activation; D007700:Kinetics; D009206:Myocardium / Q000201:enzymology; D010084:Oxidation-Reduction; D013053:Spectrophotometry
D002248:Carbon Monoxide; D003576:Electron Transport Complex IV