Twenty-four-hour intragastric acidity and plasma gastrin concentration in healthy subjects and patients with duodenal or gastric ulcer, or pernicious anaemia.
Twenty-four-hour intragastric acidity and plasma gastrin concentration were measured in healthy subjects (n = 16), and patients with duodenal (n = 12) or gastric (n = 10) ulceration, or pernicious anaemia (n = 8). Median integrated 24-hour intragastric acidity was highest in duodenal ulcer patients and lowest in pernicious anaemia patients (1148 and 0 mmol.hour litre-1, respectively). Median integrated 24-hour plasma gastrin was highest in pernicious anaemia and lowest in the healthy subjects (9886 and 238 pmol.hour litre-1, respectively). Pernicious anaemia patients have unremitting hypergastrinaemia throughout the 24 hours. The results of this study not only provide a reference range of acidity and plasma gastrin in health and disease, but also will act as a baseline for future studies using antisecretory drugs.
Lanzon-Miller
S
S
Academic Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
Pounder
R E
RE
Hamilton
M R
MR
Chronos
N A
NA
Ball
S
S
Mercieca
J E
JE
Olausson
M
M
Cederberg
C
C
D000328:Adult; D000368:Aged; D000752:Anemia, Pernicious / Q000097:blood / Q000503:physiopathology*; D002940:Circadian Rhythm; D004381:Duodenal Ulcer / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013276:Stomach Ulcer / Q000097:blood / Q000503:physiopathology*
D005755:Gastrins