Dissociated expression of receptors for interleukin 2 and transferrin in the presence of preformed suppressor T cells and interleukin 2.
In vitro activated suppressor cells were tested for their ability to inhibit TFR expression. Interleukin 2 receptors and TFR are similarly suppressed on both CD4+ and CD8+ T cells. Addition of exogenous rIL2 permits appearance of IL2R but not TFR on CD4+ and CD8+ T cells. In the presence of rIL2, however, the percentage of CD4+ T cells is significantly diminished, while Leu11-positive natural killer cells escape the regulatory effect of Ts.
Loertscher
R
R
Department of Medicine, Royal Victoria Hospital, Montreal, Quebec, Canada.
D007376:Interleukin-2 / Q000494:pharmacology; D007958:Leukocyte Count / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D010641:Phenotype; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D011990:Receptors, Transferrin / Q000378:metabolism*; D011994:Recombinant Proteins / Q000494:pharmacology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism*
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D011990:Receptors, Transferrin; D011994:Recombinant Proteins