Genetic brain malformations recapitulate phylogeny.
It is generally difficult to establish whether a congenital brain malformation has a genetic basis or is due to other factors. A thesis has been developed, that brain malformations with a genetic basis recapitulate phylogeny. In order to validate this thesis a retrospective CT investigation of brain dysmorphology was carried out in 50 cases of dysgenesis of the corpus callosum, 20 cases of the holoprosencephaly complex, 25 cases of Dandy-Walker malformation, and 50 cases of miscellaneous brain anomalies. This group was compared with 100 neonates with brain damage from acquired causes. The results strongly suggest that a brain malformation that recapitulates phylogeny is very likely to be based on genetic aberration.
Sarwar
M
M
Department of Radiology, University of Illinois, Chicago.
D000818:Animals; D001921:Brain / Q000002:abnormalities* / Q000196:embryology; D006801:Humans; D007231:Infant, Newborn; D010802:Phylogeny