Bacterial resistance to streptothricins.
Resistance to streptothricin was studied in bacteria with different resistance mechanisms. The laboratory-induced streptothricin-resistant mutant E. coli A19 Stcr 2/2/1 showed a high level of cross-resistance to aminoglycosides and other miscoding inducing antibiotics. In contrast, aminoglycosid-resistant E. coli strains with plasmid-determined aminoglycoside modifying enzymes were sensitive to streptothricin. Enzymatic inactivation of streptothricin by acetylation was demonstrated for the streptothricin producing Streptomyces noursei, strain NG13. This strain showed no cross-resistance to miscoding inducing aminoglycosides.
Haupt
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Thrum
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D000107:Acetylation; D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003429:Cross Reactions; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D009154:Mutation; D013309:Streptothricins / Q000494:pharmacology*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D013309:Streptothricins