Activity of A-56268 (TE-031), a new macrolide, against Toxoplasma gondii in mice.
The activity of A-56268 (TE-031), a new macrolide, was tested in a murine model of acute toxoplasmosis. All control animals died in 8 +/- 1 days, while all mice treated with nine daily doses of A-56268 at 300 mg/kg, administered by gavage, survived. Moreover, 41.6% of the surviving mice were free from cerebral infection with Toxoplasma gondii, as assessed by brain subpassage. A-56268 is active against T. gondii in vivo, but further studies are needed to determine its usefulness in the treatment of human toxoplasmosis.
Chang
H R
HR
Department of Microbiology, University of Geneva Medical School, Switzerland.
Rudareanu
F C
FC
Pechère
J C
JC
D000818:Animals; D017291:Clarithromycin; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D014122:Toxoplasma / Q000187:drug effects*; D014124:Toxoplasmosis, Animal / Q000188:drug therapy
D004917:Erythromycin; D017291:Clarithromycin