Neuroendocrine effects of diazepam in normal subjects following brief painful stress.
The neuroendocrine effects of 5 and 10 mg of oral diazepam were assessed in 10 normal subjects under baseline (prestress) and laboratory-controlled stressful conditions. Although the 10-mg diazepam dose had no effect on cortisol at baseline, it significantly reduced the increase in cortisol produced by 15 minutes of exposure to a painful electrical stimulus. There were no significant effects on growth hormone, beta-endorphin or ACTH, either at baseline or after painful stimulation.
Roy-Byrne
P P
PP
Department of Psychiatry, University of Washington, Seattle.
Risch
S C
SC
Uhde
T W
TW
D000328:Adult; D003975:Diazepam / Q000009:adverse effects*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D010146:Pain / Q000097:blood; D013312:Stress, Physiological / Q000097:blood*; D001615:beta-Endorphin / Q000097:blood
D001615:beta-Endorphin; D003975:Diazepam; D006854:Hydrocortisone