Lack of influence of low-dose acetylsalicylic acid (100 mg daily) on platelet survival time, beta-thromboglobulin and platelet factor 4 in patients with peripheral arterial occlusive disease.
In this study we investigated the influence of low-dose (100 mg daily) acetylsalicylic acid (ASA) on 111-In-platelet survival time (PST) and on plasma levels of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF 4) in 30 patients (median age: 60 years) with arteriographically proven peripheral arterial occlusive disease in a chronic stable phase. We observed no significant changes of PST during therapy with ASA (weighted mean: 169.8----166 [median] hours; multiple hit: 168.3----170.6 hours), and also the plasma levels of beta-TG (median: 31.8----32.3 ng/ml) and of PF 4 (3.6----3.9 ng/ml) remained unchanged.
Minar
E
E
Department of Angiology, I. Medical University Clinic, Vienna, Austria.
Ehringer
H
H
Jung
M
M
Koppensteiner
R
R
Stümpflen
A
A
D000328:Adult; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000097:blood* / Q000188:drug therapy; D001241:Aspirin / Q000008:administration & dosage*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010978:Platelet Factor 4 / Q000378:metabolism*; D017713:Platelet Transfusion; D001620:beta-Thromboglobulin / Q000378:metabolism*
D007205:Indium Radioisotopes; D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; D001241:Aspirin