Effect of chronic ethanol treatment on dopamine receptor subtypes in rat striatum.
Chronic exposure to ethanol (6% in the drinking water, 25 days) reduces the responsiveness of both the dopamine-stimulated and of the dopamine-inhibited adenylate cyclase in rat striatum. The changes in the adenylate cyclase activity are paralleled by alterations in dopamine recognition sites, in fact binding studies using selective ligands indicate that the number of both D1- and D2-receptors is reduced in striatal membranes of treated rats.
Lucchi
L
L
Institute of Pharmacological Sciences, University of Milan, Italy.
Moresco
R M
RM
Govoni
S
S
Trabucchi
M
M
D000262:Adenylyl Cyclases / Q000378:metabolism; D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2
D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D001971:Bromocriptine; D000431:Ethanol; D000262:Adenylyl Cyclases; D004298:Dopamine