Analysis of solid-state Carbon-13 NMR spectra of polymorphs (benoxaprofen and nabilone) and pseudopolymorphs (cefazolin).
The solid-state 13C-NMR spectra of the polymorphs of benoxaprofen, nabilone, and cefazolin are reported using the cross-polarization/magic-angle spinning (CP/MAS) technique. In general, the spectra of the different crystal forms are different. In favorable cases the spectra of the drug in a pharmaceutical granulation can be discerned. These results provide a preliminary indication that solid-state NMR spectroscopy is a useful technique for the investigation of drug polymorphs and drugs in their dosage forms.
Byrn
S R
SR
Gray
G
G
Pfeiffer
R R
RR
Frye
J
J
D000893:Anti-Inflammatory Agents / Q000032:analysis*; D000932:Antiemetics / Q000032:analysis*; D002247:Carbon Isotopes; D002437:Cefazolin / Q000032:analysis*; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D011422:Propionates / Q000032:analysis*
D000893:Anti-Inflammatory Agents; D000932:Antiemetics; D002247:Carbon Isotopes; D011422:Propionates; C011677:benoxaprofen; C011941:nabilone; D013759:Dronabinol; D002437:Cefazolin