title: Activity of A-56268 (TE-031), a new macrolide, against Toxoplasma gondii in mice.
abstract: The activity of A-56268 (TE-031), a new macrolide, was tested in a murine model of acute toxoplasmosis. All control animals died in 8 +/- 1 days, while all mice treated with nine daily doses of A-56268 at 300 mg/kg, administered by gavage, survived. Moreover, 41.6% of the surviving mice were free from cerebral infection with Toxoplasma gondii, as assessed by brain subpassage. A-56268 is active against T. gondii in vivo, but further studies are needed to determine its usefulness in the treatment of human toxoplasmosis.
authors.affiliation: Department of Microbiology, University of Geneva Medical School, Switzerland.
authors.forename: H R
authors.initials: HR
authors.lastname: Chang
authors.forename: F C
authors.initials: FC
authors.lastname: Rudareanu
authors.forename: J C
authors.initials: JC
authors.lastname: Pechère
mesh_terms: D000818:Animals; D017291:Clarithromycin; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D014122:Toxoplasma / Q000187:drug effects*; D014124:Toxoplasmosis, Animal / Q000188:drug therapy
chemical_list: D004917:Erythromycin; D017291:Clarithromycin