Basic pharmacological properties of a novel antiinflammatory drug tryptamide.
In rats and mice the basic pharmacological properties of tryptamide (TRP), a novel antiinflammatory substance were studied. The LD50 doses were for male rats 1260 mg/kg ip or 8.5 g/kg po, for male mice: 1980 mg/kg ip or 9.3 g/kg po. TRP produced evident antiinflammatory effects of potency comparable with those of phenylbutazone when studied by means of carrageenin-induced rat paw oedema and prostaglandin synthetase activity in vitro. TRP reversed pyrogen-induced hyperthermia in rats, elicited analgesic effects in rats, but not in mice, prolonged the time of hexobarbital sleep in rats and inhibited locomotor activity in rats and mice. TRP has not elicited side effects on the circulatory system of rats and cats. It is concluded that TRP may undergo clinical trials as a potential antiinflammatory drug. During these trials the attention should be paid to possible central side effects the drug.
Herman
Z S
ZS
Department of Clinical Pharmacology, Silesian Medical Academy, Katowice-Ligota.
Brus
R
R
Sokoła
A
A
Szkilnik
R
R
Kmieciak-Kołada
K
K
Zieliński
M
M
Stańda
J
J
Trzeciak
H I
HI
D000700:Analgesics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D002415:Cats; D002417:Cattle; D004487:Edema / Q000188:drug therapy; D005260:Female; D005528:Foot; D006339:Heart Rate / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D010653:Phenylbutazone / Q000494:pharmacology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014363:Tryptamines / Q000494:pharmacology* / Q000633:toxicity
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014363:Tryptamines; D009536:Niacinamide; C057564:tryptamide; D011451:Prostaglandin-Endoperoxide Synthases; D010653:Phenylbutazone