Effect of long-term therapy with estrogen and progesterone on the endometrium of post-menopausal women.
We studied a group of 398 patients who had been receiving estrogen replacement therapy since 1976. Group I consisted of 138 patients who received Premarin (conjugated equine estrogen, Ayerst) in two different dosages (0.625; 1.25 mg) and progestational agents such as Neogest (Norgestrel, Schering), Duphaston (Dydrogesterone, Duphar) 5 mg and Primolut N (Norethisterone, Schering) 5 mg, for a period ranging between 7 and 21 days. Group II consisted of 106 patients who received Harmogen (Piperazine Oestrone Sulphate, Abbott) in two different dosages (1.5 mg; 2.25 mg) with the above-mentioned progestational agents for a period ranging between 7 and 21 days. Group III consisted of 154 patients who received Progynova (Oestradiol Valerate, Schering) in two different dosages (1 mg; 2 mg) with the above-mentioned progestational agents for a period ranging between 7 and 21 days. When increasing dosages of estrogen with progestational agents were added for 7 days, this produced cystic hyperplasia of the endometrium. When the duration of progestational agents was increased to 10 days or more, a more atrophic and secretory endometrium resulted and there was no incidence of cystic hyperplasia.
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D000368:Aged; D001284:Atrophy; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004394:Dydrogesterone / Q000494:pharmacology; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology; D004970:Estrone / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D006801:Humans; D006965:Hyperplasia; D016912:Levonorgestrel; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D009640:Norethindrone / Q000494:pharmacology; D009644:Norgestrel / Q000494:pharmacology; D011372:Progestins / Q000494:pharmacology*; D013997:Time Factors
D003277:Contraceptives, Oral, Combined; D004967:Estrogens; D004966:Estrogens, Conjugated (USP); D011372:Progestins; D004970:Estrone; D009644:Norgestrel; D004958:Estradiol; D016912:Levonorgestrel; D004394:Dydrogesterone; C009927:estropipate; D009640:Norethindrone