title: Changes in coronary blood flow and myocardial metabolism during aortic balloon valvuloplasty.
abstract: The effects of balloon inflation on myocardial perfusion and metabolism were studied during aortic valvuloplasty in 17 patients with aortic stenosis, including 6 with associated coronary artery disease. Coronary sinus flow and blood samples were obtained before and during the first inflation, and 5 to 10 minutes after the last inflation. During inflation, coronary blood flow decreased (272 +/- 111 standard deviation to 166 +/- 92 ml/min; p less than 0.05), myocardial oxygen uptake fell and transcardiac lactate handling shifted from extraction to production (35 +/- 54 to -41 +/- 48 mumol/min; p less than 0.01). At the end of the procedure, aortic valve area had increased from 0.51 +/- 0.22 to 0.81 +/- 0.48 cm2 (p less than 0.002). Coronary sinus flow increased slightly above control values (+6%; difference not significant) and myocardial oxygen and lactate uptakes were back to control values. However, myocardial alanine production had increased from -3.6 to -6.6 mumol/min (p less than 0.05) and glutamine production was reduced or replaced by extraction (-3.3 +/- 2.1 to 3.5 +/- 3.8 mumol/min; p less than 0.05). Recovery of coronary flow, oxygen and lactate uptakes was not significantly different in patients with or without coronary artery disease, although the former patients tended to have less glutamine extraction and less improvement in their ejection fraction at the end of the procedure. Thus, aortic balloon valvuloplasty produces brief episodes of low-flow ischemia. Recovery of oxidative metabolism is almost immediate after deflation and no detrimental effect seems to persist at the end of the procedure.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Cardiac Catheterization and Interventional Cardiology Unit, St. Luc University Hospital, Brussels, Belgium.
authors.forename: M F
authors.initials: MF
authors.lastname: Rousseau
authors.forename: W
authors.initials: W
authors.lastname: Wyns
authors.forename: F
authors.initials: F
authors.lastname: Hammer
authors.forename: D
authors.initials: D
authors.lastname: Caucheteux
authors.forename: L
authors.initials: L
authors.lastname: Hue
authors.forename: H
authors.initials: H
authors.lastname: Pouleur
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000409:Alanine / Q000378:metabolism; D000800:Angioplasty, Balloon; D001024:Aortic Valve Stenosis / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D003326:Coronary Circulation; D005260:Female; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D007773:Lactates / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption; D013318:Stroke Volume
chemical_list: D007773:Lactates; D005973:Glutamine; D000409:Alanine