Nickel chloride protection against alloxan- and streptozotocin-induced diabetes.
The ability of NiCl2 to prevent alloxan- and streptozotocin-induced hyperglycemia was tested in rats. NiCl2 injected before alloxan and streptozotocin prevented the hyperglycemic response to the drugs. The protective effect of NiCl2 was linked to an increase in the specific activity of Cu-Zn superoxide dismutase (SOD). The effect of NiCl2 on SOD activity might be related to the effect of nickel on calcium, copper and zinc concentrations.
Novelli
E L
EL
Departamento de Bioquímica, Universidade Estadual de São Paulo, Botucatu, Brasil.
Rodrigues
N L
NL
Ribas
B O
BO
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002570:Ceruloplasmin / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D006943:Hyperglycemia / Q000517:prevention & control*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D009532:Nickel / Q000494:pharmacology*; D051381:Rats; D013311:Streptozocin; D013482:Superoxide Dismutase / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D013311:Streptozocin; C022838:nickel chloride; D000496:Alloxan; D009532:Nickel; D013482:Superoxide Dismutase; D002570:Ceruloplasmin