title: Identification of the protein product of the c-mos proto-oncogene in mouse testes.
abstract: The mouse c-mos proto-oncogene RNA is expressed primarily in mouse gonadal tissues and embryos. Until now, the c-mos protein has not been identified. Utilizing two different site-directed affinity purified anti-peptide antibodies, we have identified a 43 kDa c-mos protein in mouse testes and in germ cell preparations derived from testes. This 43 kDa testicular protein was found to be structurally related to a bacterially expressed c-mos protein by peptide mapping. Immunoblots of whole mouse sections were employed to establish that the c-mos protein is expressed primarily in the testes.
authors.affiliation: Department of Molecular Pathology, University of Texas, MD and Anderson Cancer Center, Houston 77030.
authors.forename: N K
authors.initials: NK
authors.lastname: Herzog
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.forename: J
authors.initials: J
authors.lastname: Elder
authors.forename: I
authors.initials: I
authors.lastname: Lipkin
authors.forename: R J
authors.initials: RJ
authors.lastname: Trauger
authors.forename: C F
authors.initials: CF
authors.lastname: Millette
authors.forename: D S
authors.initials: DS
authors.lastname: Goldman
authors.forename: H
authors.initials: H
authors.lastname: Wolfes
authors.forename: G M
authors.initials: GM
authors.lastname: Cooper
authors.forename: R B
authors.initials: RB
authors.lastname: Arlinghaus
mesh_terms: D000818:Animals; D008297:Male; D051379:Mice; D008970:Molecular Weight; D011518:Proto-Oncogene Proteins / Q000032:analysis* / Q000276:immunology; D017231:Proto-Oncogene Proteins c-mos; D013094:Spermatozoa / Q000032:analysis; D013737:Testis / Q000032:analysis*
chemical_list: D011518:Proto-Oncogene Proteins; D017231:Proto-Oncogene Proteins c-mos