title: The syndrome of hypertension and hyperkalaemia with normal glomerular function (Gordon's syndrome). A pathophysiological study.
abstract: A 14-year-old boy with the syndrome of hypertension and hyperkalaemia with normal glomerular filtration rate (Gordon's syndrome) is described. The patient's clinical symptoms consisted of periodic paralysis, slight metabolic acidosis of the proximal type and hypercalciuria. Prostaglandin excretion was normal. Infusion of atrial natriuretic peptide had no effect on electrolyte excretion or glomerular function although a normal increase in cyclic guanosine monophosphate was demonstrated in plasma and urine. This lack of sensitivity to atrial natriuretic peptide offers a new pathophysiological concept in this syndrome. Treatment with hydrochlorothiazide was successful in this case.
authors.affiliation: Department of Pediatrics, University of Nijmegen, The Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: Semmekrot
authors.forename: L
authors.initials: L
authors.lastname: Monnens
authors.forename: B G
authors.initials: BG
authors.lastname: Theelen
authors.forename: W
authors.initials: W
authors.lastname: Rascher
authors.forename: F
authors.initials: F
authors.lastname: Gabreëls
authors.forename: J
authors.initials: J
authors.lastname: Willems
mesh_terms: D000293:Adolescent; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D005919:Glomerular Filtration Rate; D006801:Humans; D006947:Hyperkalemia / Q000150:complications / Q000503:physiopathology*; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000503:physiopathology*; D008297:Male; D010243:Paralysis / Q000209:etiology; D013577:Syndrome
chemical_list: D009320:Atrial Natriuretic Factor