title: A unique type of cyclic AMP-binding protein of Trypanosoma cruzi.
abstract: On centrifugation on sucrose density gradients, the cyclic AMP-receptor protein of Trypanosoma cruzi was clearly resolved from the type II regulatory subunit of protein kinase from bovine heart (S20,W = 8.25 and 4.1, respectively). The binding of cyclic [3H]AMP to these two proteins was affected to different extents by several cyclic AMP analogues. Such differences between the cyclic AMP-receptor protein of T. cruzi and cyclic AMP-binding proteins of other eukaryotes might be exploitable by chemotherapy.
authors.forename: R
authors.initials: R
authors.lastname: Rangel-Aldao
authors.forename: O
authors.initials: O
authors.lastname: Allende
authors.forename: E
authors.initials: E
authors.lastname: Cayama
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D002499:Centrifugation, Density Gradient; D000242:Cyclic AMP / Q000378:metabolism; D011953:Receptors, Cyclic AMP / Q000032:analysis*; D014349:Trypanosoma cruzi / Q000032:analysis*
chemical_list: D011953:Receptors, Cyclic AMP; D000242:Cyclic AMP