[Structure-activity relationship of ceftazidime. Consequences on the bacterial spectrum].
The structure-activity relationships of antibiotics are currently known, especially for cephalosporins. Ceftazidime, which is a new semi-synthetic drug, possesses as side chains an aminothiazole ring and a propylcarboxy moiety at position 7, and at position 3 a pyridine group similar to that of cephaloridine: these structural modifications of the cephalosporin nucleus confer upon ceftazidime increased affinity for penicillin-binding-proteins of Gram negative bacilli, a high stability to beta-lactamases and an enlarged spectrum of antibacterial activity including Pseudomonas and Acinetobacter. The presence at position 3 of a pyridine group is responsible for a rapid intrabacterial penetration of ceftazidime and for favourable pharmacokinetic properties.
Bergogne-Bérézin
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Service de Microbiologie, CHU Xavier-Bichat, Paris.
D002442:Ceftazidime / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D002442:Ceftazidime
Relation structure-activité de la ceftazidime. Conséquences sur le spectre bactérien.