Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen.
The monoclonal antibody 4B4 blocked the T8+ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4+ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.
Matsushita
S
S
Department of Genetics, Kyushu University, Fukuoka, Japan.
Morimoto
C
C
Schlossman
S F
SF
Sasazuki
T
T
D000911:Antibodies, Monoclonal / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D007165:Immunosuppression Therapy; D066298:In Vitro Techniques; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014197:Trees
D000911:Antibodies, Monoclonal; D007073:Immunoglobulin E