Hypotensive response to atrial natriuretic factor in conscious chronic pulmonary hypertensive rats.
The hypotensive effects of anaritide (Wy-47,663), a 26 amino acid atrial natriuretic factor, were examined in conscious, monocrotaline-induced chronic pulmonary hypertensive rats. Anaritide (0.25-8 micrograms/kg per min i.v.) decreased systemic arterial pressure at 2-8 micrograms/kg per min by as much as -15.6 +/- 0.4 mm Hg. The pulmonary hypotensive response to anaritide was not different from vehicle treatment. We conclude that anaritide is more effective in decreasing systemic than pulmonary arterial pressures in monocrotaline-induced pulmonary hypertensive rats.
Lee
K C
KC
Wyeth-Ayerst Research, Princeton, NJ 08540.
Lappe
R W
RW
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D016686:Monocrotaline; D010446:Peptide Fragments / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000187:drug effects / Q000503:physiopathology; D011763:Pyrrolizidine Alkaloids; D051381:Rats; D011919:Rats, Inbred Strains
D010446:Peptide Fragments; D011763:Pyrrolizidine Alkaloids; C042703:anaritide; D016686:Monocrotaline; D009320:Atrial Natriuretic Factor