Effects of idebenone (CV-2619) on endogenous monoamine release and cyclic AMP formation in diencephalon slices from rats.
The addition of CV-2619 (10(-4) M) stimulated the release of endogenous 5-hydroxytryptamine (5-HT) markedly and that of norepinephrine (NE) slightly from slices of rat diencephalon, but it did not affect dopamine (DA) release. The addition of CV-2619 (10(-5)-10(-4) M) or 5-HT (10(-6)-10(-4) M) stimulated cyclic AMP formation in a concentration-dependent manner. Methysergide (10(-4) M), a 5-HT receptor blocker, almost completely blocked CV-2619 (10(-4) M)- and 5-HT (10(-4) M)-induced cyclic AMP formation. These results suggest that CV-2619 stimulates cyclic AMP formation via endogenous monoamine, particularly, 5-HT release.
Narumi
S
S
Nagaoka
A
A
Nagawa
Y
Y
D000818:Animals; D016227:Benzoquinones; D001679:Biogenic Amines / Q000378:metabolism*; D000242:Cyclic AMP / Q000096:biosynthesis*; D004027:Diencephalon / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D011809:Quinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013806:Theophylline / Q000494:pharmacology; D014451:Ubiquinone / Q000031:analogs & derivatives
D016227:Benzoquinones; D001679:Biogenic Amines; D011809:Quinones; D014451:Ubiquinone; D012701:Serotonin; D013806:Theophylline; D000242:Cyclic AMP; C036619:idebenone; D004298:Dopamine; D009638:Norepinephrine