Vasodilator responses to alpha-human-atrial natriuretic peptide in isolated omental and pulmonary arteries from rabbit and man.
In isolated vessels from the pulmonary and mesenteric/omental arterial circulations of rabbit and man, the effects of synthetic alpha-human atrial natriuretic peptide (alpha-hANP) were investigated. The vessels had an outer diameter of 0.6-1.2 mm and were contracted by noradrenaline (NA) and prostaglandin (PG) F2 alpha (mesenteric/omental arteries) or by 5-hydroxytryptamine (5-HT) and PGF2 alpha (pulmonary arteries). It was found that in rabbits, mesenteric vessels contracted by NA and PGF2 alpha were not significantly relaxed by alpha-hANP. Rabbit pulmonary vessels contracted by PGF2 alpha or 5-HT were concentration-dependently relaxed by alpha-hANP (maximum 70%). Human omental vessels contracted by NA and PGF2 alpha showed a moderate (30%) relaxation after addition of the peptide. Human pulmonary arteries contracted by 5-HT were relaxed by alpha-hANP almost to baseline, while PGF2 alpha-contracted vessels showed a maximum relaxation of 65%. It is concluded that alpha-hANP has a relatively selective effect on pulmonary arterial vessels from rabbit as well as man. The results suggest that the peptide may be involved in the regulation of pulmonary vascular tone.
Lindberg
F
F
Department of Clinical Pharmacology, Lund University Hospital, Sweden.
Andersson
K E
KE
D000328:Adult; D000368:Aged; D000818:Animals; D001158:Arteries / Q000187:drug effects*; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D015237:Dinoprost / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects*; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D009852:Omentum / Q000098:blood supply; D011651:Pulmonary Artery / Q000187:drug effects*; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*
D012701:Serotonin; D009320:Atrial Natriuretic Factor; D015237:Dinoprost; D009638:Norepinephrine