Genetic determinants of resistance to ectromelia (mousepox) virus-induced mortality.
Resistance to ectromelia (mousepox) virus-induced mortality was examined in crosses between susceptible DBA/2J, A/J, and BALB/cByJ mice and resistant C57BL/6J and AKR/J mice. Depending on the cross, resistance to mousepox virus was shown to be determined by one or more independently assorting autosomal loci with dominant alleles for resistance in AKR/J and C57BL/6J mice and recessive alleles in A/J, BALB/cByJ, and DBA/2J mice. A sexual dimorphism in resistance to disease was also observed.
Wallace
G D
GD
Buller
R M
RM
Morse
H C
HC
D000818:Animals; D004198:Disease Susceptibility; D004482:Ectromelia, Infectious / Q000235:genetics* / Q000276:immunology; D005260:Female; D005796:Genes; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D011213:Poxviridae Infections / Q000235:genetics*; D012737:Sex Factors