title: Deep venous thrombosis, inflammatory bowel disease, and protein S deficiency.
abstract: The authors observed a patient with severe inflammatory bowel disease (IBD) complicated by ten episodes of deep venous thrombosis (DVT). Her unusual thrombotic tendency prompted further investigation for primary hypercoagulability. A nonfamilial deficiency of Protein S was documented suggesting the deficiency was acquired. This occurrence suggests that low Protein S levels should be considered as a potential etiologic factor in patients with IBD and recurrent DVT.
authors.affiliation: Department of Medicine, Brown University, Providence, Rhode Island.
authors.forename: E
authors.initials: E
authors.lastname: Wyshock
authors.forename: M
authors.initials: M
authors.lastname: Caldwell
authors.forename: J P
authors.initials: JP
authors.lastname: Crowley
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006023:Glycoproteins / Q000172:deficiency*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D017293:Protein S; D011517:Prothrombin Time; D013924:Thrombophlebitis / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D006023:Glycoproteins; D017293:Protein S; D014859:Warfarin; D006493:Heparin