cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.
Interleukin-1 alpha and -1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. A direct expression strategy was used to clone the receptor for IL-1 from mouse T cells. The product of the cloned complementary DNA binds both IL-1 alpha and IL-1 beta in a manner indistinguishable from that of the native T cell IL-1 receptor. The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long.
Sims
J E
JE
Immunex Corporation, Seattle, WA 98101.
March
C J
CJ
Cosman
D
D
Widmer
M B
MB
MacDonald
H R
HR
McMahan
C J
CJ
Grubin
C E
CE
Wignall
J M
JM
Jackson
J L
JL
Call
S M
SM
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005786:Gene Expression Regulation; D005803:Genes, Immunoglobulin; D007375:Interleukin-1 / Q000502:physiology*; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D011971:Receptors, Immunologic / Q000235:genetics*; D017472:Receptors, Interleukin-1
D007375:Interleukin-1; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1; D004247:DNA