title: Collisional spectroscopy as a screening procedure for the determination of FFI in complex natural matrices.
abstract: The build-up of brown products on long-lived proteins could be an important factor in determining long-term diabetic complications. A brown product 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole (FFI), present in the acid hydrolysate mixtures of beta-polylysine and beta-albumin has been identified by collisional spectroscopy, using a commercial double-focusing, reverse-geometry mass spectrometer. Using this approach the analyses were carried out without any sample derivatization or need for chromatographic separation procedures.
authors.affiliation: Istituto di Medicina Interna, Patologia Medica I., Policlinico Universitario, Padova, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Poli
authors.forename: A
authors.initials: A
authors.lastname: Lapolla
authors.forename: B
authors.initials: B
authors.lastname: Pelli
authors.forename: A
authors.initials: A
authors.lastname: Sturaro
authors.forename: P
authors.initials: P
authors.lastname: Traldi
authors.forename: G
authors.initials: G
authors.lastname: Crepaldi
authors.forename: D
authors.initials: D
authors.lastname: Fedele
mesh_terms: D000418:Albumins / Q000032:analysis; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D007093:Imidazoles / Q000032:analysis*; D011107:Polylysine / Q000032:analysis; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D000418:Albumins; D007093:Imidazoles; D011107:Polylysine; C041306:2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole