[Changes in Na, K-ATPase activity in subcellular fractions of the lumbar region of the spinal cord in botulism and the possibility of their pharmacological correction].
Inhibition of Na, K-ATPase in fractions of unpurified synaptosomes and of heavy microsomes from lumbar part of spinal cord was found in dynamics of botulinic intoxication of the C type in rats. Both competitive and noncompetitive types of inhibition of the enzymatic activity were found in kinetic studies. Inhibition of transport functions across biological membranes caused by botulinic toxin was shown to have a reversible character. The inhibition might be prevented within the early periods of botulinic intoxication by administration of serotonin and guanidine hydrochloride.
Chesnokova
N P
NP
Nevvazhaĭ
T A
TA
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001906:Botulism / Q000188:drug therapy / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D019791:Guanidine; D006146:Guanidines / Q000494:pharmacology; D006868:Hydrolysis; D007700:Kinetics; D008161:Lumbosacral Region; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013116:Spinal Cord / Q000201:enzymology*; D013347:Subcellular Fractions / Q000201:enzymology
D006146:Guanidines; D012701:Serotonin; D000255:Adenosine Triphosphate; D000254:Sodium-Potassium-Exchanging ATPase; D019791:Guanidine
Izmeneniia aktivnosti Na, K-ATFazy subkletochnykh fraktsiĭ poiasnichnogo otdela spinnogo mozga v dinamike botulinicheskoĭ intoksikatsii i vozmozhnosti ikh farmakologicheskoĭ korrektsii.