[Herpes simplex infection after kidney transplantation under immunosuppression by cyclosporin. Diagnostic and therapeutic experiences].
Incidence and course of herpes simplex infections was determined prospectively in 22 patients who had a kidney transplant and were treated with cyclosporin. In addition to clinical findings, serial studies were undertaken of throat washings for herpes simplex virus in cell culture, as well as of patient sera for herpes-specific IgG and IgM antibodies. There were 13 clinically manifest infections, 12 of them localized, while one had dissemination with necrotizing retinitis. Virus demonstration was successful in all cases in which virostatic drugs had not yet been used. Asymptomatic virus excretion was noted in three cases. Significant IgG titre rise occurred in six of the 13 cases, but a positive IgM titre in only two. Acyclovir proved to be an effective virostatic drug with few side effects. The outcome in the localized infections was favourable, but in the disseminated one residual defects remained.
Dalhoff
K
K
Dennin
R H
RH
Schulz
E
E
Sack
K
K
Hoyer
J
J
D000212:Acyclovir / Q000627:therapeutic use; D003524:Cyclosporins / Q000009:adverse effects*; D006566:Herpesviridae Infections / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation
D003524:Cyclosporins; D000212:Acyclovir
Herpes-simplex-Infektionen nach Nierentransplantation unter Immunsuppression mit Ciclosporin. Diagnostische und therapeutische Erfahrungen.