A comparative immunoperoxidase and histopathologic study of condylomata acuminata.
Thirty-seven lesions from 29 patients with condylomata acuminata were comparatively studied by peroxidase-antiperoxidase (PAP) technique and routine histopathology. PAP staining demonstrated papillomavirus common antigen (PCA) mostly in the granular layer of the epidermis in 22 of 37 lesions (59%) of condylomata acuminata. Presence of PCA is closely correlated with the following histopathologic findings: 1) coarse keratohyalin granules; 2) perinuclear vacuolization or koilocytotic cells in the granular layer; 3) hyperkeratosis with focal parakeratosis. From these findings it is concluded that these histopathologic findings suggest the presence of PCA, and that the presence of papillomavirus may play a role in the formation of these histopathologic features of condylomata acuminata.
Kimura
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S
Masuda
M
M
D000951:Antigens, Neoplasm / Q000032:analysis*; D000956:Antigens, Viral / Q000032:analysis*; D003218:Condylomata Acuminata / Q000276:immunology / Q000473:pathology*; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006801:Humans; D007124:Immunoenzyme Techniques; D007642:Keratosis / Q000473:pathology; D027383:Papillomaviridae / Q000276:immunology*; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*; D014617:Vacuoles / Q000648:ultrastructure
D000951:Antigens, Neoplasm; D000956:Antigens, Viral