Insulin-like growth factor-I (IGF-I) and IGF-I receptor in human testis: an immunohistochemical study.
Using specific monoclonal antibodies, the authors studied the distribution of insulin growth factor-I (IGF-I) and its receptor in normal human testis by immunostaining techniques. IGF-I was preferentially localized in Sertoli cells. Less evident positivity was found in primary spermatocytes. In the interstitium some Leydig cells were positive for IGF-I. The major positivity for the IGF-I receptor was found in secondary spermatocytes and early spermatids, whereas Sertoli cells were less positive. An intense positivity was found in some Leydig cells.
Vannelli
B G
BG
Department of Human Anatomy, University of Florence, Italy.
Barni
T
T
Orlando
C
C
Natali
A
A
Serio
M
M
Balboni
G C
GC
D000911:Antibodies, Monoclonal; D006801:Humans; D007124:Immunoenzyme Techniques; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D011972:Receptor, Insulin / Q000032:analysis*; D017451:Receptors, Somatomedin; D012708:Sertoli Cells / Q000032:analysis; D013002:Somatomedins / Q000032:analysis*; D013087:Spermatids / Q000032:analysis; D013090:Spermatocytes / Q000032:analysis; D013737:Testis / Q000032:analysis*
D000911:Antibodies, Monoclonal; D017451:Receptors, Somatomedin; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D011972:Receptor, Insulin