title: Pathology of macrovascular disease.
abstract: In this chapter we have presented information on the development of large vessel damage in diabetes mellitus. A series of changes occur independent of the presence of atherosclerosis. The abnormalities include accumulation of PAS-positive material, laminin, fibronectin, type IV collagen and connective tissue with lack of acid mucopolysaccharides, and deposition of calcium. It is of particular interest that accumulation of PAS-positive material and lack of acid mucopolysaccharides are recognized as the histological markers of diabetic microangiopathy. These changes are in agreement with the hypothesis of a non-atherosclerotic large vessel damage, that is, diabetic macroangiopathy. From this standpoint the working hypothesis of a specific diabetic macroangiopathy should generate new ways to study the mechanism of the large vessel disease of diabetes over and above the traditional concept of classical atherosclerosis.
authors.forename: T
authors.initials: T
authors.lastname: Ledet
authors.forename: L
authors.initials: L
authors.lastname: Heickendorff
authors.forename: L M
authors.initials: LM
authors.lastname: Rasmussen
mesh_terms: D000818:Animals; D001158:Arteries / Q000473:pathology* / Q000648:ultrastructure; D003921:Diabetes Mellitus, Experimental / Q000473:pathology; D003925:Diabetic Angiopathies / Q000473:pathology*; D006025:Glycosaminoglycans / Q000032:analysis; D006801:Humans; D010503:Periodic Acid-Schiff Reaction
chemical_list: D006025:Glycosaminoglycans