Marked acceleration of the autoimmune disease in MRL-lpr/lpr mice by the influence of the Yaa gene from BXSB mice.
MRL-lpr, Yaa males were developed by the transfer of the Yaa gene from BXSB males to the MRL-lpr strain. The early-onset autoimmune disease of MRL-lpr males was accelerated further by the action of Yaa. All the serological parameters of autoimmune disease examined, i.e., anti-DNA antibodies, rheumatoid factors and circulating immune complexes were elevated earlier in MRL-lpr, Yaa males than in MRL-lpr males. Consequently, the MRL-lpr, Yaa males showed the clinical signs of an earlier and more rapidly progressive glomerulonephritis as compared with MRL-lpr males. The lifespan of MRL-lpr, Yaa males was shortened by about 50% in comparison to MRL-lpr males, with 90% of MRL-lpr, Yaa males dead by about 4 months of age. The clinical features and overall intensity of the autoimmune responses in the terminal stages appeared to be similar in both MRL-lpr, Yaa and MRL-lpr males. Thus, Yaa appeared merely to accelerate the disease course of MRL-lpr males, without altering the essential nature of the disease.
Miyawaki
S
S
Research Laboratories, Nippon Shinyaku Co., Ltd., Kyoto, Japan.
Nakamura
Y
Y
Takeshita
T
T
Yoshida
H
H
Shibata
Y
Y
Mitsuoka
S
S
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology / Q000401:mortality / Q000662:veterinary*; D004247:DNA / Q000276:immunology; D004277:DNA, Single-Stranded / Q000276:immunology; D005260:Female; D005921:Glomerulonephritis / Q000662:veterinary; D007105:Immune Complex Diseases / Q000662:veterinary; D008198:Lymph Nodes / Q000473:pathology; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D012217:Rheumatoid Factor / Q000032:analysis; D012376:Rodent Diseases / Q000235:genetics* / Q000276:immunology / Q000401:mortality; D013601:T-Lymphocytes / Q000276:immunology
D000906:Antibodies; D000936:Antigen-Antibody Complex; D004277:DNA, Single-Stranded; D004247:DNA; D012217:Rheumatoid Factor