Interaction of flavonoid compounds with contractile proteins of skeletal muscle.
Flavonoids (quercetin, rutin) influence ATPase activity and actomyosin superprecipitation. Low concentrations (below 20 mumol/l) of flavonoids were found to cause conformational changes in the myosin structure accompanied by an increase in ATPase activity. At higher concentrations an inhibitory action of flavonoids on both ATPase activity and actomyosin superprecipitation occurred. Conformational changes are likely to be due to flavonoids binding to regulatory site near the active centre of the myosin head. The effect of quercetin was stronger than that of rutin.
Zyma
V L
VL
Department of Biophysics, T. G. Shevchenko Kiev State University, USSR.
Miroshnichenko
N S
NS
Danilova
V M
VM
En Gin
E
E
D000205:Actomyosin / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D011232:Chemical Precipitation; D005419:Flavonoids / Q000378:metabolism*; D009218:Myosins / Q000378:metabolism*; D011487:Protein Conformation; D011794:Quercetin / Q000378:metabolism*; D011817:Rabbits; D012431:Rutin / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
D005419:Flavonoids; D012431:Rutin; D000205:Actomyosin; D011794:Quercetin; D000251:Adenosine Triphosphatases; D009218:Myosins