Specificity of renotropin receptors in murine Wilms tumor model.
Contralateral kidneys, removed forty-eight hours after unilateral nephrectomy, contain renotropic growth factors with different effects on normal kidney and Wistar/Furth rat Wilms tumor. Receptors on tumor cells bind factors which, when eluted followed by in vivo bioassay, stimulate the growth of Wilms tumor. Receptors on normal kidney cortex cells bind factors which, when eluted, produce kidney hypotrophy in nontumor-bearing rats.
Tritsch
G L
GL
Williams
P D
PD
Sufrin
G
G
Murphy
G P
GP
D000818:Animals; D002458:Cell Fractionation; D006133:Growth Substances / Q000378:metabolism*; D006984:Hypertrophy; D036341:Intercellular Signaling Peptides and Proteins; D007668:Kidney / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000378:metabolism*; D051381:Rats; D011920:Rats, Inbred WF; D011956:Receptors, Cell Surface / Q000378:metabolism*; D009396:Wilms Tumor / Q000378:metabolism*
D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D011956:Receptors, Cell Surface; C010320:renotropins