Percutaneous absorption of hydrocortisone during and after the acute phase of dermatitis in children.
Percutaneous absorption of hydrocortisone was measured by a four-hour absorption test in 16 children during and after the acute phase of dermatitis. In the acute phase, after the application of 1% hydrocortisone cream the increment in plasma cortisol ranged from 47 to 961 nmol per liter (median 248 nmol/L). After the acute phase the increment was significantly (P less than 0.01) lower: range 18 to 241 nmol per liter (median 95 nmol/L). In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease. Convalescence is connected with a diminished systemic effect due to the restoration of the skin barrier to hydrocortisone.
Turpeinen
M
M
Department of Allergic Diseases, University Central Hospital, Helsinki, Finland.
Lehtokoski-Lehtiniemi
E
E
Leisti
S
S
Salo
O P
OP
D000208:Acute Disease; D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D012628:Dermatitis, Seborrheic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006854:Hydrocortisone; D007223:Infant; D008297:Male; D012869:Skin Absorption
D000893:Anti-Inflammatory Agents; D006854:Hydrocortisone