title: [Characteristics of the clinical and immunologic safety of inactivated influenza vaccines in children undergoing multiple immunizations].
abstract: In a strictly controlled epidemiological trial on 12,643 school children aged 11-14 years the reactogenic properties and safety of killed influenza chromatographic vaccine under the conditions of multiple immunization were studied. A single immunization dose of the vaccine (0.2 ml) contained the hemagglutinins of influenza viruses A/Philippines/82 (H3N3) and A/Kiev/59/79 (H1N1), 3.5 micrograms each. The preparation was introduced by means of a jet injector. The vaccine was shown to be clinically and immunologically safe under the conditions of the regular multiple immunization of children over the period of 4 years.
authors.forename: R I
authors.initials: RI
authors.lastname: Vasil'eva
authors.forename: L A
authors.initials: LA
authors.lastname: Merkur'eva
authors.forename: V G
authors.initials: VG
authors.lastname: Iatsenko
authors.forename: A M
authors.initials: AM
authors.lastname: Vasil'eva
authors.forename: M M
authors.initials: MM
authors.lastname: Shvager
mesh_terms: D000293:Adolescent; D000917:Antibody Formation; D002648:Child; D004341:Drug Evaluation; D006801:Humans; D007117:Immunization, Secondary; D007073:Immunoglobulin E / Q000032:analysis; D007252:Influenza Vaccines / Q000009:adverse effects* / Q000276:immunology; D007277:Injections, Jet; D011897:Random Allocation; D012426:Russia; D013997:Time Factors; D014505:Urban Population; D015164:Vaccines, Inactivated / Q000009:adverse effects / Q000276:immunology
chemical_list: D007252:Influenza Vaccines; D015164:Vaccines, Inactivated; D007073:Immunoglobulin E
vernacular_title: Kharakteristika klinicheskoĭ i immunologicheskoĭ bezvrednosti grippoznykh inaktivirovannykh vaktsin dlia deteĭ v usloviiakh mnogokratnoĭ immunizatsii.