Mesoblastic nephroma contains fibronectin but lacks laminin.
Non-metastatic mesoblastic nephromas from four young children were shown to contain fibronectin but not laminin using an immunoperoxidase staining procedure. In contrast, one metastasising spindle celled sarcomatous tumour from a neonate was laminin positive. During embryogenesis primitive nephrogenic mesenchyme contains only fibronectin and no laminin; metanephric blastema (permanent kidney) is positive for laminin. The staining for fibronectin and laminin may help to ascertain the histogenesis of different types of renal tumour.
Kumar
S
S
Marsden
H B
HB
Carr
T
T
Kodet
R
R
D005260:Female; D005353:Fibronectins / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007680:Kidney Neoplasms / Q000032:analysis* / Q000473:pathology; D007797:Laminin / Q000032:analysis*; D008297:Male; D012509:Sarcoma / Q000032:analysis; D009396:Wilms Tumor / Q000032:analysis* / Q000473:pathology
D005353:Fibronectins; D007797:Laminin