title: Tumor promoters enhance basal and growth hormone releasing factor stimulated cyclic AMP levels in anterior pituitary cells.
abstract: Tumor promoters, such as phorbol esters and teleocidin, amplified the ability of growth hormone releasing factor to increase pituitary cyclic AMP levels. This effect of tumor promoters was concentration-dependent, could be observed in 5 minutes, and was over by 4 hours. Inactive tumor promoters (i.e., 4-alpha-didecanoate) had no effect on this system, whereas a synthetic diacylglycerol (i.e., 1-oleoly-2-acetyl glycerol), mimicked the action of tumor promoters. Due to the known stimulation of protein kinase C by both tumor promoters and diacylglycerols, we suggest that this calcium and phospholipid dependent protein kinase C can enhance the ability of the growth hormone releasing factor receptor to activate the cyclic AMP generating system.
authors.forename: M J
authors.initials: MJ
authors.lastname: Cronin
authors.forename: P L
authors.initials: PL
authors.lastname: Canonico
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D004075:Diglycerides / Q000494:pharmacology; D005260:Female; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D008235:Lyngbya Toxins / Q000494:pharmacology; D008297:Male; D010703:Phorbol Esters / Q000494:pharmacology; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D011493:Protein Kinase C; D011494:Protein Kinases / Q000378:metabolism; D051381:Rats
chemical_list: D002273:Carcinogens; D004075:Diglycerides; D008235:Lyngbya Toxins; D010703:Phorbol Esters; C022176:teleocidins; C038237:1-oleoyl-2-acetylglycerol; D013007:Growth Hormone-Releasing Hormone; D000242:Cyclic AMP; D011494:Protein Kinases; D011493:Protein Kinase C