title: Causes of death to age 30 in Down syndrome.
abstract: To look at the underlying cause of death (U.C.O.D.) data for Down syndrome (DS), we studied 324 DS individuals who died out of a total of 1,337 DS births occurring in 1,066,508 consecutive live births during the years 1952-81 inclusive. U.C.O.D. rates, separated into ICD-9 classifications, for the DS population were compared with those of the age-matched general population. In general, an individual with DS is significantly more likely to die than the age-matched general population over all ages studied up to age 30. The greatest absolute likelihood of dying is under 1 year, but the age group with the greatest relative risk of dying (17.2) is very definitely between ages 1-9. In order, the three categories for causes of death in DS with the greatest relative risk are congenital anomalies, circulatory system, and respiratory system.
authors.affiliation: Department of Medical Genetics, University of British Columbia, Canada.
authors.forename: P A
authors.initials: PA
authors.lastname: Baird
authors.forename: A D
authors.initials: AD
authors.lastname: Sadovnick
mesh_terms: D000059:Accidents; D000367:Age Factors; D001955:British Columbia; D002318:Cardiovascular Diseases / Q000150:complications; D003141:Communicable Diseases / Q000150:complications; D004066:Digestive System Diseases / Q000150:complications; D004314:Down Syndrome / Q000150:complications / Q000401:mortality*; D004700:Endocrine System Diseases / Q000150:complications; D006402:Hematologic Diseases / Q000150:complications; D006801:Humans; D008607:Intellectual Disability / Q000150:complications; D009369:Neoplasms / Q000150:complications; D009422:Nervous System Diseases / Q000150:complications; D012120:Respiration Disorders / Q000150:complications; D012307:Risk Factors