Alpha 1-noradrenergic receptor blockade decreases nuclear estrogen receptor binding in guinea pig hypothalamus and preoptic area.
Prazosin, a putative alpha 1-noradrenergic antagonist, reduced nuclear estrogen receptor levels in the hypothalamus and preoptic area of the estrogen-primed guinea pig. Noradrenergic transmission may alter steroid-dependent processes and neuroendocrine function through actions on steroid-concentrating cells.
Clark
A S
AS
Nock
B
B
Feder
H H
HH
Roy
E J
EJ
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D007033:Hypothalamus, Middle / Q000187:drug effects*; D009638:Norepinephrine / Q000502:physiology; D011224:Prazosin / Q000494:pharmacology*; D011301:Preoptic Area / Q000187:drug effects*; D011799:Quinazolines / Q000494:pharmacology*; D011960:Receptors, Estrogen / Q000187:drug effects*; D011980:Receptors, Progesterone / Q000032:analysis; D009435:Synaptic Transmission
D011799:Quinazolines; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D009638:Norepinephrine; D011224:Prazosin