title: Formulation and stability of iopentol.
abstract: The autoclaving studies which were performed to develop a formulation of iopentol are presented. The same formulation as used for iohexol was found to be suitable for iopentol. It was shown that it is essential to use a buffer such as trometamol to lower the pH during autoclaving in order to achieve a low level of deiodination after autoclaving. Results from the on-going stability studies indicate a good stability of iopentol finished product.
authors.affiliation: Analytical Chemistry Department, Nycomed AS, Oslo, Norway.
authors.forename: K
authors.initials: K
authors.lastname: Skinnemoen
authors.forename: R
authors.initials: R
authors.lastname: Fagervoll
authors.forename: L
authors.initials: L
authors.lastname: Aanstad
authors.forename: T
authors.initials: T
authors.lastname: Jacobsen
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D004355:Drug Stability; D006358:Hot Temperature; D014283:Triiodobenzoic Acids / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C053571:iopentol