Hypothalamic monoaminergic mechanisms of aspirin-induced analgesia in monkeys.
Microinjection of sodium acetylsalicylate (aspirin, 0.2-0.6 mg) into the preoptic anterior hypothalamic area, but not the dorsal raphe region or the periaqueductal central gray matter, produced a dose-related analgesia in conscious monkeys. The analgesia induced by intrahypothalamic administration of aspirin was antagonized by pretreatment of monkeys with either a serotoninergic receptor blocker (cyproheptadine) or two catecholaminergic receptor blockers (haloperidol and yohimbine). These suggest the existence of a monoaminergic pain-inhibitory mechanism in the preoptic anterior hypothalamic area activated by aspirin.
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D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D008251:Macaca; D008297:Male; D010487:Periaqueductal Gray / Q000187:drug effects; D011301:Preoptic Area / Q000187:drug effects*; D011903:Raphe Nuclei / Q000187:drug effects; D011941:Receptors, Adrenergic / Q000187:drug effects; D017983:Receptors, Catecholamine; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects; D012684:Sensory Thresholds / Q000187:drug effects
D000700:Analgesics; D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine; D017981:Receptors, Neurotransmitter; D011985:Receptors, Serotonin; D001241:Aspirin