title: Blood brain barrier modification and chemotherapy. Interventional neuroradiology in the treatment of malignant gliomas.
abstract: Postoperative interventional neuroradiology was performed in patients with malignant gliomas to increase target efficacy of chemotherapy. In 8 glioma patients the blood brain or blood tumor barrier was reversibly opened by intraarterial injection of hyperosmolar fluid (Mannitol 25%). One additional patient had primary lymphoma of the central nervous system. During barrier modification chemotherapeutic agents were applied intraarterially and intravenously. A total of 22 blood brain barrier modification procedures have been carried out until now, ranging from one to five per patient. A presently continuing tumor regression or tumor progression free intervals have been noted in 5 patients. Therapeutic effects are being evaluated from repeated computed tomography and single photon emission computed tomography examinations.
authors.affiliation: Department of Neurology, Vienna University Clinics, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Heimberger
authors.forename: P
authors.initials: P
authors.lastname: Samec
authors.forename: H
authors.initials: H
authors.lastname: Binder
authors.forename: I
authors.initials: I
authors.lastname: Podreka
authors.forename: T
authors.initials: T
authors.lastname: Reisner
authors.forename: L
authors.initials: L
authors.lastname: Deecke
authors.forename: A
authors.initials: A
authors.lastname: Horaczek
authors.forename: C
authors.initials: C
authors.lastname: Dittrich
authors.forename: G
authors.initials: G
authors.lastname: Steger
authors.forename: M
authors.initials: M
authors.lastname: Zimpfer
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D003131:Combined Modality Therapy; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008353:Mannitol / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D009994:Osmolar Concentration; D015641:Radiography, Interventional; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D008353:Mannitol