[Immunomodulating action of a preparation of yeast dsRNA on cellular immunity in mice].
The effect of a dsRNA preparation (an interferon inductor) on DTH induced by SRBC was studied. It was shown that at optimal antigenic load the dsRNA preparation inhibited DTH whereas at suboptimal and supraoptimal loads the preparation stimulated it. The findings indicated that the dsRNA preparation had an immunoregulatory effect. The immunoregulatory properties of the preparation must be associated with its action on the lymphocyte suppressor cells and macrophages.
Fadina
V A
VA
Razvorotnev
V A
VA
D000276:Adjuvants, Immunologic; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects*; D007114:Immunization; D007369:Interferon Inducers; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D010587:Phagocytosis / Q000187:drug effects; D012330:RNA, Double-Stranded / Q000494:pharmacology*; D012331:RNA, Fungal / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D012331:RNA, Fungal
Izuchenie immunomoduliruiushchego deĭstviia preparata drozhzhevoĭ dsRNK na kletochnyĭ immunitet u mysheĭ.