Heterogeneity in the specificities of an alloreactive T helper cell line.
Heterogeneity in antigen recognition of an alloreactive helper T-cell line was studied by repeated limiting dilution cloning. Analysis of the fine specificities of these clones showed that the gain of reactivity to new antigens by the T-cell line included the generation of non-cross-reactive T cells specific to new major histocompatibility (MHC) antigens. Analysis of function revealed that all the T-cell clones studied had similar cell surface antigens and secreted interleukin 4 (IL-4) and IL-5/IL-3 but not IL-2 or gamma interferon (IFN-gamma). The T-cell clones served as helper cells for B cells expressing the appropriate MHC antigens to both clonal proliferation and differentiation into antibody-producing cells.
Rajasekar
R
R
Department of Immunology, University of Uppsala, Sweden.
Andersson
J
J
Leanderson
T
T
D000818:Animals; D002999:Clone Cells / Q000276:immunology; D006183:H-2 Antigens / Q000276:immunology; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D006183:H-2 Antigens; D008222:Lymphokines