Effect of a novel thermogenic beta-adrenoceptor agonist (BRL 26830) on insulin resistance in soleus muscle from obese Zucker rats.
Young lean (Fa/?) and obese (fa/fa) rats were treated with the thermogenic beta-adrenoceptor agonist, BRL 26830, for 3 weeks. In lean rats this treatment had no effect on body weight but there was a marked increase in the insulin sensitivity of soleus muscle strips with respect to glycolytic rate. Treatment of obese rats with BRL 26830 produced a small but not significant decrease in body weight but the sensitivity of both glycolysis and glycogen synthesis to insulin was increased so that muscles of treated obese rats showed similar insulin sensitivity to untreated lean rats. It is suggested that such changes are unlikely to be merely a secondary consequence of an anti-obesity action.
Challiss
R A
RA
Budohoski
L
L
Newsholme
E A
EA
Sennitt
M V
MV
Cawthorne
M A
MA
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004983:Ethanolamines / Q000494:pharmacology*; D006003:Glycogen / Q000096:biosynthesis; D007333:Insulin Resistance; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D009132:Muscles / Q000187:drug effects*; D009765:Obesity / Q000378:metabolism*; D051381:Rats; D011924:Rats, Zucker; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D001786:Blood Glucose; D004983:Ethanolamines; D007773:Lactates; D011943:Receptors, Adrenergic, beta; D019344:Lactic Acid; C039248:BRL 26830A; D006003:Glycogen