[Brain blood supply and beta-endorphin and corticotropin content on exposure to thyroliberin].
Thyroliberin produces a marked depressant action on the reflex cerebrovascular constriction reactions. The lack of changes in the content of immunoreactive beta-endorphine in blood and CSF indicates that apparently the cerebrovascular effects of the drug are not mediated via the opioid system but are due to a direct influence of thyroliberin on the central mechanisms by which brain circulation is regulated. Thyroliberin increases the blood corticotropin content, which causes an elevation of the arterial blood pressure and cerebrovascular tension. On the contrary, in the CSF the corticotropin level decreases after thyroliberin administration. The data obtained show that there is no correlation between the content of beta-endorphine and corticotropin in blood and CSF under the action of thyroliberin.
Mirozoian
R S
RS
Gan'shina
T S
TS
Ragimov
Kh S
KhS
Mirzoian
R A
RA
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004723:Endorphins / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D001615:beta-Endorphin
D004723:Endorphins; D013973:Thyrotropin-Releasing Hormone; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone
Krovosnabzhenie mozga i soderzhanie beta-éndorfina i kortikotropina pri deĭstvii tiroliberina.