[Development of cardiac adenylate cyclase hypersensitivity to isoproterenol in the chronic action of propranolol on rats].
The chronic treatment of rats with the beta-adrenergic antagonist propranolol causes a double increase in the amount of beta-adrenergic receptors in the cardiac membranes. The purpose of the paper is to investigate the effect of propranolol on the activity and regulatory properties of rat heart adenylate cyclase. Propranolol injections to rats for 3 weeks (10-20 mg/l kg bw) did not influence the enzyme basal activity but caused a rise of a degree of myocardial adenylate cyclase activation by isoproterenol and glucagon.
Tkachuk
V A
VA
Cherkasova
T D
TD
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D004342:Drug Hypersensitivity / Q000209:etiology*; D004789:Enzyme Activation / Q000187:drug effects; D005934:Glucagon / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D009206:Myocardium / Q000201:enzymology*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013997:Time Factors
D011943:Receptors, Adrenergic, beta; D005934:Glucagon; D011433:Propranolol; D000262:Adenylyl Cyclases; D007545:Isoproterenol
Razvitie giperchuvstvitel'nosti adenilattsiklazy serdtsa k izoproterenolu pri khronicheskom deĭstvii propranolola na krys.