Occupational sensitization to epichlorohydrin and epoxy resin.
Sensitization to epichlorohydrin (ECH) is reported in 6 patients with occupational contact allergy. In 2 cases, an isolated positive test to ECH was found. In the remaining 4 cases, concomitant positive reactions were seen to "ICDRG epoxy resin" (MW 385) and to liquid epoxy resin (MW 370). Allergy to bisphenol A was not seen in the patients. 5 patients worked in an epoxy resin plant. Adequate preventive measures to avoid skin contact with ECH are required to prevent ECH sensitization becoming a more serious industrial hazard.
van Joost
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Department of Dermatology and Venereology, University Hospital Rotterdam/Dijkzigt, Erasmus University, The Netherlands.
D000328:Adult; D002728:Chlorohydrins / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000139:chemically induced* / Q000517:prevention & control; D009783:Dermatitis, Occupational / Q000139:chemically induced* / Q000517:prevention & control; D004811:Epichlorohydrin / Q000009:adverse effects*; D004853:Epoxy Resins / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
D002728:Chlorohydrins; D004853:Epoxy Resins; D004811:Epichlorohydrin