[Concentration of the atrial natriuretic factor in the atria and blood plasma in the development of hypertension in spontaneously hypertensive rats].
The contribution of atrial natriuretic factor to the development of spontaneous arterial hypertension was investigated in rats (the SHR line). Prehypertensive atrial and plasma levels of a natriuretic factor were similar in SHR to those of the control WKY rats. In fully-developed hypertension, the factor content decreases in left-atrial wall and increases in the plasma. It is assumed that elevated arterial blood pressure affects myo-endocrine left-atrial cells, leading to hypersecretion of the natriuretic factor. This kind of secretory response might be an adaptive/compensatory mechanism of blood pressure control.
Horký
K
K
Gutkowska
J
J
Cantin
M
M
Genet
J
J
Garcia
R
R
D000375:Aging / Q000378:metabolism; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000032:analysis* / Q000276:immunology; D006325:Heart Atria / Q000032:analysis; D006973:Hypertension / Q000378:metabolism*; D009206:Myocardium / Q000032:analysis*; D011863:Radioimmunoassay; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism*; D011919:Rats, Inbred Strains / Q000378:metabolism*; D011921:Rats, Inbred WKY
D009320:Atrial Natriuretic Factor
Kontsentratsiia predserdnogo natriĭureticheskogo faktora v predserdiiakh i plazme krovi v razvitii gipertenzii u spontanno gipertenzivnykh krys.