Suloctidil treatment prevents the development of post-traumatic feline spinal cord ischemia.
The effects of suloctidil (1.0 mg/kg i.v.) on white matter spinal cord blood flow (SCBF) and somatosensory evoked potential (SEP) conduction were assessed in a feline lumbar spinal cord contusion model. SEP conduction ceased immediately after a 500 g-cm injury and did not recover. SCBF following suloctidil declined by only 12% from pre-injury levels over the 4 hr experiment as compared to a 42% decline observed following vehicle injection. Accordingly, 7/8 vehicle cats, but only 1/5 suloctidil-treated cats, had 4 hr SCBF values of less than 10 ml/100 g/min. Bradycardiac and hypotensive effects of suloctidil were also noted. The ability of suloctidil to prevent post-traumatic ischemia may be useful in the acute treatment of spinal cord injury.
Wolf
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Hall
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D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D006339:Heart Rate / Q000187:drug effects; D007511:Ischemia / Q000209:etiology / Q000517:prevention & control*; D011412:Propanolamines / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D013116:Spinal Cord / Q000098:blood supply*; D013119:Spinal Cord Injuries / Q000150:complications* / Q000503:physiopathology; D013468:Suloctidil / Q000494:pharmacology*
D011412:Propanolamines; D013468:Suloctidil