Isoxazoles with antipicornavirus activity.
The synthesis and evaluation of a series of 3,5-disubstituted isoxazoles as antipicornavirus agents have led to the discovery of several compounds effective in vitro against rhinovirus type 2 and poliovirus type 2. Compound 32 was found more effective than 4',6-dichloroflavan against both viruses and was evaluated orally in mice infected intracerebrally with polio-2. At 31 mg/kg bid, compound 32 showed a 53% survival rate as compared to 22% for the nonmedicated animals.
Diana
G D
GD
McKinlay
M A
MA
Brisson
C J
CJ
Zalay
E S
ES
Miralles
J V
JV
Salvador
U J
UJ
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D007555:Isoxazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D010080:Oxazoles / Q000494:pharmacology*; D010849:Picornaviridae / Q000187:drug effects*; D010850:Picornaviridae Infections / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D007555:Isoxazoles; D010080:Oxazoles