Periarticular fibrosis associated with idiopathic retroperitoneal fibrosis.
We describe a previously unreported association of retroperitoneal fibrosis with biopsy proven periarticular inflammatory fibrosis. Histologic features were strikingly similar at the 2 sites. Plasma levels of a platelet derived growth factor, connective tissue activating peptide III, were found to be elevated and may play a role in pathogenesis. A dramatic response of the periarticular process to corticosteroids correlated with improvement of other variables of disease activity.
Ewald
E A
EA
Department of Internal Medicine, University of Michigan, Ann Arbor 48109-0531.
Gikas
P W
PW
Castor
C W
CW
D000328:Adult; D000843:Ankle Joint / Q000473:pathology*; D004551:Elbow Joint / Q000473:pathology*; D005260:Female; D005355:Fibrosis; D006133:Growth Substances / Q000097:blood; D006801:Humans; D010455:Peptides / Q000097:blood; D011241:Prednisone / Q000627:therapeutic use; D012185:Retroperitoneal Fibrosis / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D001620:beta-Thromboglobulin / Q000097:blood
D006133:Growth Substances; D010455:Peptides; D001620:beta-Thromboglobulin; C009862:connective tissue-activating peptide; D011241:Prednisone