Colchicine causes intrasomatic neurofilament bundles in the mesencephalic trigeminal nucleus and intradendritic bundles in other brain regions.
The effect of a single intracerebroventricular injection of colchicine on the distribution of organelles in neurons of the mesencephalic nucleus of the trigeminal nerve, the inferior colliculus and the deep cerebellar nuclei was studied. In the mesencephalic nucleus of the trigeminal nerve colchicine produced a dramatic accumulation of neurofilament bundles in the soma of these neurons and did not produce a reduction in the number of lysosomes. In other neuronal populations studied, colchicine produced neurofilament bundles in the dendrites and a reduction of lysosomes from the soma of neurons.
Ribak
C E
CE
Department of Anatomy and Neurobiology, University of California, Irvine 92717.
Gorenstein
C
C
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000648:ultrastructure; D003078:Colchicine / Q000494:pharmacology*; D007382:Intermediate Filaments / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D014278:Trigeminal Nuclei / Q000187:drug effects / Q000648:ultrastructure
D003078:Colchicine