[Effect of various concentrations of nitrosodimethylamine on the functional state of enzyme systems in rat liver mitochondria depending upon the duration of exposure].
Activities of glutamate-, succinate-, malate dehydrogenases and H+-ATPase were studied in liver tissue and these of malate- and glutamate dehydrogenases--in blood serum of rats which received nitrosodimethylamine (0.1, 1.0 and 10 mg per I l of water) within 2.5 and 10 months. Cyclic alterations in activities of malate- and succinate dehydrogenases were found in liver tissue of these rats, while the activities of glutamate dehydrogenase and H+-ATPase were changed depending on concentration and duration of the carcinogen effect. Unfavourable alterations in the functional state of mitochondrial enzymatic systems were increased according to intensity and duration of nitrosodimethylamine effect.
Litvinov
N N
NN
Astakhova
L F
LF
Mukhambetova
L Kh
LKh
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D004128:Dimethylnitrosamine / Q000493:pharmacokinetics / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D010084:Oxidation-Reduction; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013997:Time Factors
D008291:Malate Dehydrogenase; D013385:Succinate Dehydrogenase; D005969:Glutamate Dehydrogenase; D000251:Adenosine Triphosphatases; D004128:Dimethylnitrosamine
Vliianie razlichnykh kontsentratsiĭ nitrozodimetilamina na funktsional'noe sostoianie fermentnykh sistem mitokhondriĭ pecheni krys v zavisimosti ot dlitel'nosti vozdeĭstviia.