Chronic T-cell lymphocytosis with neutropenia. Its association with Epstein-Barr virus infection.
Chronic T-cell lymphocytosis with neutropenia has primarily been reported in adults. We have cared for a 14-year-old patient with this condition for over five years. This patient consistently had greater than 90% lymphocytes in his differential cell count. The majority of these cells had the OKT8 phenotype. Serologic studies demonstrated evidence for a chronic Epstein-Barr infection with elevated antibody titers to both early antigen and to the viral capsid antigen. Patients presenting with this condition should be carefully evaluated for possible viral infection.
Herrod
H G
HG
Wang
W C
WC
Sullivan
J L
JL
D000293:Adolescent; D000380:Agranulocytosis / Q000150:complications*; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000276:immunology; D036022:Capsid Proteins; D002908:Chronic Disease; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007244:Infectious Mononucleosis / Q000097:blood* / Q000276:immunology; D007958:Leukocyte Count; D008218:Lymphocytosis / Q000150:complications* / Q000209:etiology; D008297:Male; D009503:Neutropenia / Q000150:complications* / Q000209:etiology; D013601:T-Lymphocytes / Q000145:classification; D006377:T-Lymphocytes, Helper-Inducer; D050378:T-Lymphocytes, Regulatory
D000914:Antibodies, Viral; D000956:Antigens, Viral; D036022:Capsid Proteins; C041788:Epstein-Barr viral capsid antigen; D007074:Immunoglobulin G