The diuretic effect of metipamide and its relationship to body weights in rats.
Metipamide [M], a new Czechosclovak diuretic with a hypotensive effect, was administered in a dose of 20 mg/kg (about 500-fold the therapeutic dose) I. for three weeks to rats of both sexes kept under normal conditions in groups of five, and II, for eight days to single male rats in metabolic cages. The animals' body weight and food and water consumption were studied and in the second series their daily faeces, urine and urinary sodium and potassium excretion were measured. Rats kept in individual cages were also given indapamide (I), the first diuretic with a separate hypotensive effect used in other countries, in a dose of 20 mg/kg. The experimental animals' body weight was significantly lower than that of controls with the same food consumption and their water intake and urine flow were much higher, especially after M. Sodium (and to a lesser extent potassium) excretion was raised at the outset of administration of both the test substances and again after the 5th to 8th dose, but only after M. After three weeks' administration of M. SNa, SK and S(osm) values were within normal limits. but after eight days the serum electrolytes and the osmolality of the serum were markedly reduced. After I. these values were normal. We conclude that the strong diuretic effect of M is not the only cause of lower body weight in rats.
Machová
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Research Institute for Pharmacy and Biochemistry, Prague.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D007190:Indapamide / Q000031:analogs & derivatives / Q000494:pharmacology*; D008297:Male; D011188:Potassium / Q000097:blood / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D012964:Sodium / Q000097:blood / Q000652:urine
D000959:Antihypertensive Agents; D004232:Diuretics; C050506:metipamide; D012964:Sodium; D007190:Indapamide; D011188:Potassium