Familial adult T-cell leukemia.
Two siblings who developed adult T-cell leukemia (ATL) are presented. The patient and 7 of 26 healthy family members examined had the serum antibodies against ATL-associated antigens (ATLA). This family study shows that two main routes of transmission of human T-cell leukemia virus (HTLV) may be involved: one is the route from parents to children and the other is horizontal transmission among spouses, especially from husband to wife; the anti-ATLA-positive family is considered to be a high-risk group for ATL.
Miyamoto
Y
Y
Yamaguchi
K
K
Nishimura
H
H
Takatsuki
K
K
Motoori
T
T
Morimatsu
M
M
Yasaka
T
T
Ohya
I
I
Koga
T
T
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology; D017977:Deltaretrovirus / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D010375:Pedigree; D013601:T-Lymphocytes / Q000473:pathology
D000914:Antibodies, Viral