Effect of a novel tachykinin, substance K, on salivation in rats.
A study of the effects of substance K (SK) and its synthetic fragments on salivation was performed. The rank order of potency of tachykinins that elicited salivation was as follows: physalaemin greater than substance P greater than eledoisin greater than kassinin greater than Arg-SK-(1-10) greater than SK-(1-10) greater than SK-(3-10). SK-(6-10) showed no activity. Atropine (1 mg/kg i.v.) had no effect on SK-induced salivation.
Takano
Y
Y
Takeda
Y
Y
Doteuchi
M
M
Inouye
K
K
Kamiya
H
H
D000595:Amino Acid Sequence; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D015288:Neurokinin A; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D012472:Salivation / Q000187:drug effects*; D013329:Structure-Activity Relationship; D015320:Tachykinins
D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D015320:Tachykinins; D015288:Neurokinin A