Influence of hyperglycemia on Ca2+-Mg2+ -ATPase of red blood cells from diabetic patients.
The influence of hyperglycemia on calmodulin-stimulated Ca2+-Mg2+-ATPase activity was studied in 20 diabetic subjects. A clear inverse relationship between short-term hyperglycemia as well as chronic hyperglycemia and calmodulin-stimulated Ca2+-Mg2+-ATPase activity could be demonstrated. Such a relationship could not be shown for basal enzyme activity.
Schaefer
W
W
Diabetes-Forschungsinstitut an der Universität Düsseldorf.
Beeker
J
J
Gries
F A
FA
D000293:Adolescent; D000328:Adult; D017301:Ca(2+) Mg(2+)-ATPase / Q000097:blood*; D000252:Calcium-Transporting ATPases / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology*; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000201:enzymology*; D008297:Male; D008875:Middle Aged
D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D006442:Glycated Hemoglobin