Subsets of T lymphocytes in peripheral blood of patients with oral lichen planus.
The T lymphocyte subsets in the peripheral blood were studied in 26 patients with oral lichen planus and in 11 normal controls. Lymphocyte subsets were identified with monoclonal antibodies (Ortho Diagnostic System Inc. Raritan, New Jersey, USA) by an indirect immunofluorescent antibody method. This study shows no significant difference between patients with oral lichen planus and healthy controls. The conclusion is that local immunity, due to the breakdown of skin-associated lymphoid tissue, not a generalized immunologic disorder, is considered to be involved in the pathogenesis of oral lichen planus.
Lin
S C
SC
Department of Dentistry, Provincial Tao-Yuan Hospital, ROC.
Hahn
L J
LJ
Kwan
H W
HW
D000328:Adult; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007958:Leukocyte Count; D008010:Lichen Planus / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000097:blood* / Q000473:pathology; D013601:T-Lymphocytes / Q000145:classification* / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000473:pathology