The effect of dietary restriction on mouse T cell functions.
Forty percent dietary restriction on 9-weeks-old C3H/He mice caused decrease of the weight of central lymphoid organs in parallel with the reduction of body weight. However, the percentage of splenic T cells was dramatically increased in diet-restricted mouse spleen cells. Generally, normal mouse spleen cells contained about 30% of Thy 1.2+ T cells, but the restricted mouse spleen cells contained 80% Thy 1.2+ T cells. Ly 1+, L3T4+ T cells, but not Ly 2+ T cells, also increased in diet-restricted mouse compared with the unrestricted mice. In parallel with the dramatic changes of splenic T cells, spleen cells obtained from diet-restricted mice showed higher immunological responses against alloantigen and interleukin 2. It was also demonstrated than nylon-passed splenic T cells obtained from diet-restricted mice showed higher levels of T cell responses against r-IL-2 and alloantigen, indicating that dietary restriction modulates T cell functions themselves.
Hishinuma
K
K
Laboratory of Nutrition, Faculty of Agriculture, Tohoku University, Sendai, Japan.
Nishimura
T
T
Konno
A
A
Hashimoto
Y
Y
Kimura
S
S
D000818:Animals; D001835:Body Weight; D004032:Diet; D007376:Interleukin-2 / Q000494:pharmacology; D007519:Isoantigens / Q000276:immunology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009929:Organ Size; D013154:Spleen / Q000033:anatomy & histology / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D013950:Thymus Gland / Q000033:anatomy & histology
D007376:Interleukin-2; D007519:Isoantigens