title: Testicular angiotensin I-converting enzyme (E.C. 3.4.15.1).
abstract: In the two mammalian species (i.e., rabbit and rat) in which it has been studied to date, testicular angiotensin I-converting enzyme possesses distinct physicochemical and immunological properties, and a susceptibility to hormonal regulation that makes it a unique isozyme of the converting enzyme ordinarily distributed throughout the body. The testicular isozyme appears to be a lower molecular weight version of the pulmonary enzyme, with similar, although not identical, catalytic properties. The testicular isozyme is under androgenic control and is associated with germinal cells. Although its function has yet to be elaborated, the testicular isozyme provides an excellent model for the study of tissue-specific regulation of carboxypeptidases.
authors.forename: P A
authors.initials: PA
authors.lastname: Velletri
mesh_terms: D000375:Aging; D000818:Animals; D002384:Catalysis; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D003429:Cross Reactions; D004790:Enzyme Induction; D006728:Hormones / Q000502:physiology; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D007700:Kinetics; D008168:Lung / Q000201:enzymology; D008297:Male; D009928:Organ Specificity; D007703:Peptidyl-Dipeptidase A / Q000276:immunology / Q000302:isolation & purification / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D012741:Sexual Maturation; D013045:Species Specificity; D013094:Spermatozoa / Q000201:enzymology; D013737:Testis / Q000201:enzymology*
chemical_list: D006728:Hormones; D007527:Isoenzymes; D007703:Peptidyl-Dipeptidase A