Serotonin-1A receptor activation in hippocampal CA1 neurons by 8-hydroxy-2-(di-n-propylamino)tetralin, 5-methoxytryptamine and 5-hydroxytryptamine.
Serotonin (5-HT) usually induced a slow hyperpolarization lasting several minutes on first drop-application onto CA1 neurons. Subsequent applications always caused a briefer (less than 2 min) hyperpolarization, usually followed by a depolarization. 8-Hydroxy-2(di-n-propylamino)tetralin, a 5-HT1A receptor agonist, and 5-methoxytryptamine, a 5-HT1 receptor agonist, produced only the long-lasting hyperpolarization. The application of 5-HT agonists caused a persistent prolongation of the post-spike train afterhyperpolarization. These observations suggest that the long-lasting hyperpolarization produced by 5-HT may be mediated by the activation of the 5-HT1A receptor subtype.
Wu
P H
PH
Neurology Program, Addiction Research Foundation, Toronto, Ont., Canada.
Gurevich
N
N
Carlen
P L
PL
D008735:5-Methoxytryptamine / Q000494:pharmacology*; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009281:Naphthalenes / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*; D014363:Tryptamines / Q000494:pharmacology*
D009281:Naphthalenes; D011985:Receptors, Serotonin; D013764:Tetrahydronaphthalenes; D014363:Tryptamines; D012701:Serotonin; D008735:5-Methoxytryptamine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin