[Changes in the activity of enzymes of renin-angiotensin and kinin systems in the rat brain after adrenalectomy and administration of hydrocortisone].
It is shown that the activity of enzymes participating in renin-angiotensin and brain kinin systems' metabolism depends on functional state of hypothalamo-pituitary-adrenocortical system. Under experimental hypocorticism the activity of angiotensin-converting enzyme and kininase I in the hypothalamus, hippocamp, corpus striatum and rat pituitary decreases; the renin-like enzyme activity decreases in the corpus striatum but increases in the hypothalamus and hippocamp. After hydrocortisone administration to adrenalectomized rats the angiotensin-converting enzyme activity of the hippocamp and pituitary is shown to be normalized as well as renin-like enzyme and kininase I of the hippocamp and corpus striatum. The activity of the studied enzymes in the hypothalamus decreases in this case.
Kalinskaia
L N
LN
Kononenko
V Ia
VIa
Iakovlev
A A
AA
D000315:Adrenalectomy; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D007705:Kinins / Q000378:metabolism*; D001121:Lysine Carboxypeptidase / Q000378:metabolism; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000187:drug effects
D007705:Kinins; D007703:Peptidyl-Dipeptidase A; D001121:Lysine Carboxypeptidase; D012083:Renin; D006854:Hydrocortisone
Izmenenie aktivnosti fermentov renin-angiotenzinovoĭ i kininovoĭ sistem mozga krys v usloviiakh adrenaléktomii i vvedeniia gidrokortizona.