title: Definitive localization of Becker muscular dystrophy in Xp by linkage to a cluster of DNA polymorphisms (DXS43 and DXS9).
abstract: A study of linkage between Becker muscular dystrophy and four X chromosome-specific DNA polymorphisms in 17 kindreds has indicated that this gene is located in Xp, as already anticipated by single pedigree analysis. In particular the DXS43 and DXS9 loci, identified by probes D2 and RC8, respectively, are closely linked to each other and are both located at approximately 15 cM from the Becker locus. These linkage data, together with the previously established linkage between Becker and the DXS7 locus identified by probe L 1.28, indicate that the Becker gene is located in the same region where Duchenne has been mapped and also yield information about relative genetic distances among different DNA polymorphisms of the X chromosome.
authors.forename: S
authors.initials: S
authors.lastname: Fadda
authors.forename: M
authors.initials: M
authors.lastname: Mochi
authors.forename: L
authors.initials: L
authors.lastname: Roncuzzi
authors.forename: S
authors.initials: S
authors.lastname: Sangiorgi
authors.forename: D
authors.initials: D
authors.lastname: Sbarra
authors.forename: M
authors.initials: M
authors.lastname: Zatz
authors.forename: G
authors.initials: G
authors.lastname: Romeo
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D009136:Muscular Dystrophies / Q000235:genetics*; D011110:Polymorphism, Genetic; D014960:X Chromosome
chemical_list: D005819:Genetic Markers; D004247:DNA; D004262:DNA Restriction Enzymes