[Cytogenetic effect of thaliblastine in a culture of human peripheral blood lymphocytes].
The mutagenicity of thaliblastine (Bulgarian potential antitumor drug) was investigated in vitro in lymphocytes from healthy donors, and in vivo in lymphocytes of oncological patients after thaliblastine administration. No increase in the rate of chromosome aberrations was noted with increasing thaliblastine concentrations in vitro and in the course of therapy in vivo. Some polyploid metaphases were found in the lymphocytes of the patients treated with thaliblastine, as a result of the statmokinetic effect of the drug. Thaliblastine exerts extraordinarily slight mutagenic effect, as compared with other cytostatics.
Khadzhidekova
V
V
Krusteva
E
E
Bulanova
M
M
Ivanov
V
V
Benova
D
D
D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D001060:Aporphines / Q000633:toxicity*; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008875:Middle Aged; D009152:Mutagenicity Tests
D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines
Tsitogenetichekiĭ éffekt taliblastina v kul'ture limfotsitov perifericheskoĭ krovi cheloveka.