title: cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.
abstract: Interleukin-1 alpha and -1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. A direct expression strategy was used to clone the receptor for IL-1 from mouse T cells. The product of the cloned complementary DNA binds both IL-1 alpha and IL-1 beta in a manner indistinguishable from that of the native T cell IL-1 receptor. The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long.
authors.affiliation: Immunex Corporation, Seattle, WA 98101.
authors.forename: J E
authors.initials: JE
authors.lastname: Sims
authors.forename: C J
authors.initials: CJ
authors.lastname: March
authors.forename: D
authors.initials: D
authors.lastname: Cosman
authors.forename: M B
authors.initials: MB
authors.lastname: Widmer
authors.forename: H R
authors.initials: HR
authors.lastname: MacDonald
authors.forename: C J
authors.initials: CJ
authors.lastname: McMahan
authors.forename: C E
authors.initials: CE
authors.lastname: Grubin
authors.forename: J M
authors.initials: JM
authors.lastname: Wignall
authors.forename: J L
authors.initials: JL
authors.lastname: Jackson
authors.forename: S M
authors.initials: SM
authors.lastname: Call
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005786:Gene Expression Regulation; D005803:Genes, Immunoglobulin; D007375:Interleukin-1 / Q000502:physiology*; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D011971:Receptors, Immunologic / Q000235:genetics*; D017472:Receptors, Interleukin-1
chemical_list: D007375:Interleukin-1; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1; D004247:DNA