title: Role of cytokines in the restoration of the delayed-type hypersensitivity reaction of anergic patients.
abstract: Soluble mediators from peripheral blood lymphocytes activated either by skin test antigens or by alloantigens restored the delayed type hypersensitivity (DTH) reaction in the majority of anergic surgical patients who are at increased risk for sepsis and mortality. Antigen had to be injected together with the mediators and the individual had to be reactive to the antigen for restoration. These results suggest that restoration of the DTH response depends on the ability of cytokines produced and acting in a non-specific manner to promote the response of the anergic patients' specific antigen-sensitive cells to antigen.
authors.affiliation: Department of Surgery, McGill University, Montreal, Canada.
authors.forename: H N
authors.initials: HN
authors.lastname: Rode
authors.forename: J C
authors.initials: JC
authors.lastname: Puyana
authors.forename: M
authors.initials: M
authors.lastname: Macphee
authors.forename: J L
authors.initials: JL
authors.lastname: Meakins
authors.forename: N
authors.initials: N
authors.lastname: Christou
authors.forename: J
authors.initials: J
authors.lastname: Gordon
mesh_terms: D000368:Aged; D001688:Biological Products / Q000494:pharmacology*; D002474:Cell-Free System; D016207:Cytokines; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000473:pathology; D007108:Immune Tolerance; D007959:Lymphocyte Culture Test, Mixed; D011183:Postoperative Complications / Q000276:immunology; D012867:Skin / Q000473:pathology; D014373:Tuberculin / Q000276:immunology
chemical_list: D001688:Biological Products; D016207:Cytokines; D014373:Tuberculin