Interactive effects of caffeine, 2-chloroadenosine and haloperidol on activity, social investigation and play fighting of juvenile rats.
The effects of caffeine, 2-chloroadenosine and haloperidol and their interaction on activity, social investigation, and two measures of play fighting (crossover and pinning), were investigated in juvenile male rats. Caffeine (20 mg/kg) increased activity, decreased crossover and pinning, but had no effect on social investigation. Both 2-chloroadenosine (0-10 mg/kg) and haloperidol (0-10 mg/kg) depressed activity, social investigation, crossover and pinning. When given together in varying dosages, caffeine and 2-chloroadenosine had behavioral effects suggestive of a competitive interaction between the two drugs. In contrast, the effects of haloperidol were not appreciably altered by simultaneous caffeine treatment. These results suggest that the influence of caffeine and 2-chloroadenosine on activity, social investigation and play fighting involve interaction with adenosine receptors.
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D015762:2-Chloroadenosine; D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000374:Aggression / Q000187:drug effects*; D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism; D011983:Receptors, Purinergic; D012919:Social Behavior
D011956:Receptors, Cell Surface; D011983:Receptors, Purinergic; D015762:2-Chloroadenosine; D002110:Caffeine; D006220:Haloperidol; D000241:Adenosine