title: Reactivity of eleven anti-human leucocyte monoclonal antibodies with lymphocytes from several domestic animals.
abstract: Nine commercially available monoclonal antibodies and two monoclonal antibodies from The American Type Culture Collection, raised against various human leucocyte surface antigens, were tested on lymphocytes from cow, sheep, goat, swine, horse, cat, dog, mink, and rabbit as well as man. Four antibodies bound to lymphocytes from some of the animals. These were the antibodies against CD8 and CD4 antigen, the antibody to C3b-receptor, and the antibody to the HLA-DR antigen. The CD8 antigen-reactive antibody reacted with lymphocytes from mink, cat, dog, and sheep, while the CD4 antigen-reactive antibody reacted with lymphocytes from mink. The anti-C3b-R antibody reacted with lymphocytes from horse, swine, dog, and cat, and the anti-HLA-DR reacted with lymphocytes from cow, goat, sheep, horse, dog, cat, and mink.
authors.affiliation: Royal Veterinary and Agricultural University of Copenhagen, Department of Veterinary Virology and Immunology, Frederiksberg C, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Aasted
authors.forename: M
authors.initials: M
authors.lastname: Blixenkrone-Møller
authors.forename: E B
authors.initials: EB
authors.lastname: Larsen
authors.forename: H
authors.initials: H
authors.lastname: Bielefeldt Ohmann
authors.forename: R B
authors.initials: RB
authors.lastname: Simesen
authors.forename: A
authors.initials: A
authors.lastname: Uttenthal
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000276:immunology*; D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D016827:CD8 Antigens; D003429:Cross Reactions; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D011951:Receptors, Complement / Q000276:immunology; D017463:Receptors, Complement 3b; D013045:Species Specificity
chemical_list: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens; D006684:HLA-DR Antigens; D011951:Receptors, Complement; D017463:Receptors, Complement 3b