title: Effect of a novel tachykinin, substance K, on salivation in rats.
abstract: A study of the effects of substance K (SK) and its synthetic fragments on salivation was performed. The rank order of potency of tachykinins that elicited salivation was as follows: physalaemin greater than substance P greater than eledoisin greater than kassinin greater than Arg-SK-(1-10) greater than SK-(1-10) greater than SK-(3-10). SK-(6-10) showed no activity. Atropine (1 mg/kg i.v.) had no effect on SK-induced salivation.
authors.forename: Y
authors.initials: Y
authors.lastname: Takano
authors.forename: Y
authors.initials: Y
authors.lastname: Takeda
authors.forename: M
authors.initials: M
authors.lastname: Doteuchi
authors.forename: K
authors.initials: K
authors.lastname: Inouye
authors.forename: H
authors.initials: H
authors.lastname: Kamiya
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D015288:Neurokinin A; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D012472:Salivation / Q000187:drug effects*; D013329:Structure-Activity Relationship; D015320:Tachykinins
chemical_list: D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D015320:Tachykinins; D015288:Neurokinin A