title: [Pharmacologic effects of atrial natriuretic peptide in humans].
abstract: Since the discovery of atrial natriuretic peptide (ANP) by de Bold in 1981, several scientists (e.g. nephrologists, endocrinologists, cardiologists) have contributed to research efforts to define the physiologic and pharmacologic profile of the peptide. ANP given in pharmacologic doses seems to lower blood pressure, probably by reducing both preload and afterload. ANP increases renal water and electrolyte excretion, although the underlying mechanisms have not been entirely clarified yet. The depressor and natriuretic effect of ANP act in harmony with an inhibitory effect on the release of renin, aldosterone, and arginine-vasopressin. While the physiologic role or importance of ANP is still in question, synthetic alpha ANP has a promising pharmacologic profile in renal and cardiovascular pathologic states.
authors.affiliation: Medizinische Poliklinik der Universität Bern.
authors.forename: H
authors.initials: H
authors.lastname: Saxenhofer
authors.forename: P
authors.initials: P
authors.lastname: Weidmann
mesh_terms: D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology; D004231:Diuresis / Q000187:drug effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology
chemical_list: D009320:Atrial Natriuretic Factor
vernacular_title: Pharmakologische Effekte des atrialen natriuretischen Peptids beim Menschen.