title: Neurotization of pectoralis major myocutaneous flap by the hypoglossal nerve in tongue reconstruction: clinical and experimental observations.
abstract: Recently, neurotization has been proposed for providing mobility to the pectoralis major, or other myocutaneous flap in lingual reconstruction following total glossectomy. The development of an active tongue-like structure may offer the patient higher potential for rehabilitation of speech and deglutition. The purpose of this thesis is to report experimental and clinical observations on neurotization of the pectoralis major myocutaneous flap. The pectoralis major myoflap of 16 rats was reinnervated by either a hypoglossal nerve pedicle of hypoglossal-genioglossus muscle neuromuscular pedicle. Functional flap reinnervation was confirmed in eight of the 16 animals. The author's clinical experience with reconstruction of the tongue utilizing neurotized pectoralis major myocutaneous flap is presented.
authors.affiliation: St. Louis University School of Medicine, MO.
authors.forename: G P
authors.initials: GP
authors.lastname: Katsantonis
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D004576:Electromyography; D005071:Evoked Potentials; D005260:Female; D005927:Glossectomy; D006801:Humans; D007002:Hypoglossal Nerve / Q000033:anatomy & histology / Q000502:physiology / Q000637:transplantation*; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D009218:Myosins / Q000032:analysis; D009412:Nerve Fibers / Q000648:ultrastructure; D009416:Nerve Regeneration; D010369:Pectoralis Muscles / Q000201:enzymology / Q000294:innervation / Q000637:transplantation*; D051381:Rats; D013524:Surgical Flaps; D014059:Tongue / Q000601:surgery*
chemical_list: D009218:Myosins