title: [The dose of intracoronary urokinase infusion in acute myocardial infarct].
abstract: In 11 patients with acute myocardial infarction (mean age 52 +/- 6 years) coronary angiography was performed 4.5 +/- 3.6 h after the onset of symptoms. The infarct-related artery was in 7 cases the right coronary artery and in 4 cases the left anterior descending branch of the left coronary artery. The infarct-related artery showed total or subtotal occlusion and no perfusion (Thrombolysis in Myocardial Infarction trial (TIMI) grade 0 or 1). In 7 cases Urokinase was infused intracoronarily at a dosage of 250,000 IU over 30 min, but in only 1 case partial reperfusion was achieved. However, all patients treated with 500,000 IU Urokinase over 30 min or 1 Mill IU over 60 min had successful reperfusion (TIMI grade 2 or 3). Thus, it appears that 500,000 IU up to 1 Mill IU of Urokinase over a period of 30 to 60 min is adequate for intracoronary thrombolysis in patients with acute myocardial infarction.
authors.affiliation: Abteilung Kardiologie und Pulmonologie, Universität Göttingen.
authors.forename: U
authors.initials: U
authors.lastname: Tebbe
authors.forename: K S
authors.initials: KS
authors.lastname: Herrmann
mesh_terms: D000328:Adult; D000368:Aged; D000800:Angioplasty, Balloon; D003131:Combined Modality Therapy; D003331:Coronary Vessels / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D014568:Urokinase-Type Plasminogen Activator
vernacular_title: Dosierung der intrakoronaren Urokinase-Infusion beim akuten Myokardinfarkt.