title: Nucleosidediphosphate-kinase induction by human recombinant IL-2 in mouse NK cells.
abstract: The ability of human recombinant IL-2 to induce NDP-kinase in mouse NK cells has been studied. A significant increase in the amount of NDP-kinase was observed when the cells were exposed to IL-2 (100 units/ml) for 3 h at 37 degrees C. The enzyme inducting ability of human recombinant IL-2 was similar to that of native mouse IL-2 in the cells. The enzymatic characteristics [chemical requirements for the phosphoenzyme formation and molecular size of two distinct subunits (18,000 and 20,000 daltons)] of NDP-kinase from IL-2 treated cells were similar to those of the enzymes from EAT cells. The enzyme's biological role in the initiation of cell proliferation by IL-2 has been discussed.
authors.forename: K
authors.initials: K
authors.lastname: Ohtsuki
authors.forename: M
authors.initials: M
authors.lastname: Yokoyama
authors.forename: F
authors.initials: F
authors.lastname: Ishii
authors.forename: N
authors.initials: N
authors.lastname: Ishida
mesh_terms: D000818:Animals; D002455:Cell Division; D003001:Cloning, Molecular; D004790:Enzyme Induction; D006801:Humans; D007376:Interleukin-2 / Q000502:physiology*; D007694:Killer Cells, Natural / Q000201:enzymology*; D051379:Mice; D008970:Molecular Weight; D009701:Nucleoside-Diphosphate Kinase / Q000096:biosynthesis*; D010770:Phosphotransferases / Q000096:biosynthesis*; D011487:Protein Conformation
chemical_list: D007376:Interleukin-2; D010770:Phosphotransferases; D009701:Nucleoside-Diphosphate Kinase