Diltiazem and left ventricular hypertrophy in renovascular hypertensive rats.
The effects of diltiazem treatment (40-50 mg/kg/day orally for 8 weeks) of left ventricular hypertrophy on systemic and coronary hemodynamics and mechanical cardiac performance were investigated in renovascular hypertensive rats (Goldblatt, two-kidney, one clip). Systemic and coronary hemodynamics were determined by using radioactive microspheres in conscious, unrestrained rats. Mechanical performance was measured on isolated papillary muscle from the same animal. Nine treated hypertensive rats were compared with control groups: 12 untreated hypertensive and nine sham-operated rats. Diltiazem treatment led to an effective but incomplete control of blood pressure (from 208 +/- 5 mm Hg in the untreated hypertensive group to 155 +/- 3 mm Hg in the treated hypertensive group; p less than 0.01) associated with a significant but incomplete decrease of the left ventricular mass (from 3.10 +/- 0.19 mg/g in untreated hypertensive rats to 2.35 +/- 0.04 mg/g in treated hypertensive rats; p less than 0.01). A close correlation was found between left ventricular mass and systolic blood pressure in untreated, treated, and pooled groups (r = 0.84, p less than 0.001, n = 30). The left ventricular weight to systolic blood pressure ratio was equivalent in all three groups, so that the reduction of left ventricular mass in diltiazem-treated rats was commensurate with the reduction of blood pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
Grellet
J P
JP
Department of Physiology and Pharmacology, Unité de Recherches de Cardiologie, Université de Bordeaux II, INSERM U8, France.
Bonoron-Adèle
S M
SM
Tariosse
L J
LJ
Besse
P J
PJ
D000284:Administration, Oral; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D006332:Cardiomegaly / Q000188:drug therapy*; D003326:Coronary Circulation / Q000187:drug effects; D004110:Diltiazem / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical; D006978:Hypertension, Renovascular / Q000188:drug therapy*; D007537:Isometric Contraction; D008297:Male; D008863:Microspheres; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D004110:Diltiazem