title: High concentrations of Lp(a) lipoprotein in serum are common among patients with abdominal aortic aneurysms.
abstract: The serum concentrations of Lp(a) lipoprotein was determined in 57 patients with abdominal aortic aneurysms (AAAs) and in 56 controls. Twentynine of the AAA-patients also suffered from other cardiovascular diseases and eleven had brothers and sisters with AAAs. Lp(a) was significantly higher among the AAA-patients than among the controls (22.3 +/- 24.3 vs 12.6 +/- 20.4 mg/dl, p less than 0.01). The 28 AAA-patients without other cardiovascular diseases had a somewhat higher Lp(a) in serum than the other AAA-patients, but this difference was not statistically significant (26.4 +/- 28.4 vs 18.5 +/- 19.3 mg/dl). The 11 AAA-patients with AAAs in the family didn't differ from the other AAA-patients concerning Lp(a) in serum. Several genetic markers were also studied, and the seven Kell-positive AAA-patients had a significantly lower Lp(a) in serum than the 47 Kell-negative AAA-patients (7.0 +/- 10.3 vs 25.7 +/- 25.2 mg/dl, p less than 0.05).
authors.affiliation: Department of Surgery, University Hospital, Umeå, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Norrgård
authors.forename: K A
authors.initials: KA
authors.lastname: Angquist
authors.forename: G
authors.initials: G
authors.lastname: Dahlen
mesh_terms: D001012:Aorta, Abdominal; D001014:Aortic Aneurysm / Q000097:blood* / Q000235:genetics; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D007626:Kell Blood-Group System / Q000235:genetics; D017270:Lipoprotein(a); D008074:Lipoproteins / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D007626:Kell Blood-Group System; D017270:Lipoprotein(a); D008074:Lipoproteins