[Controlling effect of T lymphocyte suppressors on the proliferation of cells in various tissues].
The changes in mitotic index of mouse bone marrow, spleen, liver, kidneys, small intestine, cornea were studied during alterations in the number of T-suppressors. It was found that mitotic activity in all tissues investigated enhanced significantly after a decrease in the number of T-suppressors caused by single injection of an antiserum against T-suppressors. On the contrary, the mitotic index diminished significantly after the transfer of tolerant spleen lymphoid cell suspension enriched by T-suppressors to normal syngeneic mice. These data indicate that T-suppressors are responsible for the control over cell proliferation in nonlymphoid tissues.
Kraskina
N A
NA
Veger
E M
EM
Gutorova
N M
NM
Bliakher
M S
MS
Babaeva
N V
NV
D000818:Animals; D001854:Bone Marrow Cells; D002455:Cell Division; D003315:Cornea / Q000166:cytology*; D007421:Intestine, Small / Q000166:cytology; D007668:Kidney / Q000166:cytology; D008099:Liver / Q000166:cytology; D051379:Mice; D013154:Spleen / Q000166:cytology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
Kontroliruiushchee vliianie T-limfotsitov-supressorov na proliferatsiiu kletok v razlichnykh tkaniiakh.