title: Intracellular bicarbonate and pH of skeletal muscle in chronic renal failure.
abstract: In 11 controls and 10 patients suffering from untreated uraemic acidosis intracellular bicarbonate and skeletal muscle pH (needle biopsy) were determined. In all patients a significant intracellular acidosis, not related to any extracellular indices was found. It is concluded that the chronic proton load is able to effect intracellular buffer composition; moreover the action of other factors such as derangements of cell metabolism and nutritional imbalance could be operating.
authors.forename: A
authors.initials: A
authors.lastname: Guariglia
authors.forename: C
authors.initials: C
authors.lastname: Antonucci
authors.forename: E
authors.initials: E
authors.lastname: Coffrini
authors.forename: S
authors.initials: S
authors.lastname: Del Canale
authors.forename: E
authors.initials: E
authors.lastname: Fiaccadori
authors.forename: F
authors.initials: F
authors.lastname: Reni
authors.forename: P
authors.initials: P
authors.lastname: Vitali
authors.forename: U
authors.initials: U
authors.lastname: Arduini
authors.forename: A
authors.initials: A
authors.lastname: Borghetti
mesh_terms: D000138:Acidosis / Q000150:complications / Q000378:metabolism*; D000328:Adult; D000368:Aged; D001639:Bicarbonates / Q000378:metabolism; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007424:Intracellular Fluid / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism
chemical_list: D001639:Bicarbonates