Effect of chronic administration of acetaldehyde by inhalation on (Na+ + K+)-activated adenosine triphosphatase activity of rat brain membranes.
The effect of chronic acetaldehyde inhalation on (Na+ + K+)-ATPase (EC 3.6.1.3) activities of subcellular fractions of the rat cerebral cortex was studied. Chronic administration of acetaldehyde by inhalation for 4-21 weeks caused significant increases in the enzyme activities of both the synaptosomal plasma membrane (SPM) fraction and the microsomal (MC) fraction. This indicates the change in neural membrane functions of the brain after acetaldehyde treatment. Mg2+-ATPase activities of both subcellular fractions remained unchanged after acetaldehyde treatment.
Shiohara
E
E
Tsukada
M
M
Chiba
S
S
Yamazaki
H
H
Nishiguchi
K
K
Miyamoto
R
R
Nakanishi
S
S
D000079:Acetaldehyde / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D005740:Gases; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013347:Subcellular Fractions / Q000201:enzymology; D013997:Time Factors
D005740:Gases; D000254:Sodium-Potassium-Exchanging ATPase; D000079:Acetaldehyde