Rapid haemodynamic responses to atrial natriuretic factor (99-126) in conscious sheep.
1. Haemodynamic effects of 20 micrograms and 100 micrograms injection of atrial natriuretic factor 99-126 (ANF) were studied in conscious sheep. 2. ANF injection rapidly decreased blood pressure associated with a fall in total peripheral resistance, increased heart rate and cardiac output. These parameters returned to normal within 5 min of injection. 3. This study shows that ANF has an initial vasodilatory action to decrease blood pressure, which is different from the hypotensive mechanism seen with short-term infusion (60 min) of ANF in sheep.
Parkes
D G
DG
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
Coghlan
J P
JP
McDougall
J G
JG
Scoggins
B A
BA
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D010446:Peptide Fragments / Q000494:pharmacology*; D012756:Sheep; D014655:Vascular Resistance / Q000187:drug effects
D010446:Peptide Fragments; D009320:Atrial Natriuretic Factor