Effects of atrial natriuretic factor on urinary concentration of catecholamines and renin secretion in dogs.
This study evaluated the effects of synthetic atrial natriuretic factor (ANF) on renal hemodynamics, urinary excretion of electrolytes, norepinephrine (NE), and dopamine (DA); and renal production of renin in anesthetized dogs. Following a bolus (1 micrograms/kg body weight) and infusion (0.1 microgram/kg/min) for 30 min, there was significant increase in urine flow (220 +/- 41%), glomerular filtration rate (72 +/- 14%), and urinary sodium excretion (170 +/- 34%). There was a decrease in renin secretory rate and the concentration ratio of urine NE to DA following ANF was decreased (p less than 0.05). These data suggest that ANF decreases renal production of NE and renin.
Sowers
J R
JR
Endocrinology and Hypertension Division, Wayne State University, Detroit, Michigan.
Mohanty
P K
PK
Thames
M D
MD
Goldstein
D S
DS
Atlas
S
S
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002395:Catecholamines / Q000652:urine*; D004285:Dogs; D004298:Dopamine / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007671:Kidney Concentrating Ability / Q000187:drug effects; D009638:Norepinephrine / Q000652:urine; D012083:Renin / Q000378:metabolism / Q000652:urine*; D012636:Secretory Rate / Q000187:drug effects
D002395:Catecholamines; D009320:Atrial Natriuretic Factor; D012083:Renin; D004298:Dopamine; D009638:Norepinephrine