title: Inspiratory muscle strength in asthma.
abstract: Augmentation of inspiratory muscle strength (Pimax) represents an adaptive response to airway obstruction. We explore the possibility that respiratory muscle weakness may herald hospital admission during acute bronchospasm. The Pimax measured 81 +/- 25 percent of a predicted value in 20 patients with acute bronchospasm (forced expiratory volume in one second, 36 +/- 17 percent predicted). Pimax was related to both hyperinflation (functional residual capacity, as percent predicted) and body weight (subjects were 122 +/- 29 percent ideal body weight), but not to the degree of airway obstruction per se. Furthermore, measurements of axial (craniocaudal) motion of the rib cage and asynchrony of rib cage and abdominal motions during tidal breathing did not correlate with either the degree of air flow obstruction or Pimax. We conclude that little if any respiratory muscle weakness occurs with bronchospasm. Furthermore, Pimax does not correlate with the degree of airway obstruction and does not explain abnormalities of rib cage and abdominal motion associated with asthma.
authors.affiliation: Department of Medicine (Pulmonary), University of Medicine and Dentistry of New Jersey, Newark.
authors.forename: M H
authors.initials: MH
authors.lastname: Lavietes
authors.forename: J A
authors.initials: JA
authors.lastname: Grocela
authors.forename: T
authors.initials: T
authors.lastname: Maniatis
authors.forename: F
authors.initials: F
authors.lastname: Potulski
authors.forename: A B
authors.initials: AB
authors.lastname: Ritter
authors.forename: G
authors.initials: G
authors.lastname: Sunderam
mesh_terms: D000009:Abdominal Muscles / Q000502:physiology; D000328:Adult; D001249:Asthma / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D009068:Movement; D009119:Muscle Contraction; D012123:Pulmonary Ventilation; D012132:Respiratory Muscles / Q000503:physiopathology*; D012272:Ribs