title: Studies on 44 081 R.P., a new antirhinovirus compound, in cell cultures and in volunteers.
abstract: A synthetic compound, 2-[(1,5,10,10a-tetrahydro-3H-thiazolo[3,4b]isoquinolin-3-ylidene) amino]-4-thiazoleacetic acid (S), 44 081 R.P., inhibits the multiplication of rhinoviruses in cell cultures. Of the 69 rhinovirus strains and serotypes that have been studied, 39% were inhibited at a concentration of 7 micrograms/ml, far below that which affects cellular metabolism (250 micrograms/ml). Preliminary data indicate that the compound inhibits some early events of virus replication but that some cellular functions are also involved in its mechanism of action. Despite its antiviral activity in vitro, the compound, when self-administered intranasally as a 0.2% solution to volunteers from the day before to 5 days after inoculation with a human rhinovirus strain, had no significant effect on rhinorrhea, clinical score, or laboratory evidence of infection.
authors.forename: A
authors.initials: A
authors.lastname: Zerial
authors.forename: G H
authors.initials: GH
authors.lastname: Werner
authors.forename: R J
authors.initials: RJ
authors.lastname: Phillpotts
authors.forename: J S
authors.initials: JS
authors.lastname: Willmann
authors.forename: P G
authors.initials: PG
authors.lastname: Higgins
authors.forename: D A
authors.initials: DA
authors.lastname: Tyrrell
mesh_terms: D000293:Adolescent; D000328:Adult; D000963:Antimetabolites / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002478:Cells, Cultured; D003139:Common Cold / Q000382:microbiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012229:Rhinovirus / Q000187:drug effects*; D044005:Tetrahydroisoquinolines; D013844:Thiazoles / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000963:Antimetabolites; D000998:Antiviral Agents; D044005:Tetrahydroisoquinolines; D013844:Thiazoles; C045906:RP 44081