title: Methylation pattern of the bovine leukemia provirus genome in bovine leukemic cells.
abstract: All the known genes of the bovine leukemia proviral genome were found to be heavily methylated in both fresh and short-term-cultured leukemic cells, the latter of which expressed viral antigens. However, the pXBL region appeared to be mostly demethylated or at least hypomethylated in both cells, indicating that there is a non-uniform methylation pattern of the proviral genome.
authors.forename: Y
authors.initials: Y
authors.lastname: Ogawa
authors.forename: N
authors.initials: N
authors.lastname: Sagata
authors.forename: J
authors.initials: J
authors.lastname: Tsuzuku-Kawamura
authors.forename: M
authors.initials: M
authors.lastname: Onuma
authors.forename: H
authors.initials: H
authors.lastname: Izawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ikawa
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology*; D004273:DNA, Neoplasm / Q000378:metabolism*; D005814:Genes, Viral; D007938:Leukemia / Q000382:microbiology / Q000662:veterinary*; D001909:Leukemia Virus, Bovine / Q000235:genetics*; D008745:Methylation; D012190:Retroviridae / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm