Asymmetry in the recognition of HLA-A3 molecules by virus-specific cytotoxic T cells.
Cytotoxic T cells specific for influenza virus A/HK or Epstein-Barr virus were used to study the heterogeneity of the HLA-A3 molecule. Variability of the recognition of HLA-A3 in both systems was observed. The hierarchy was both effector cell and target cell specific. An extreme example of the hierarchy of HLA-A3 recognition is the following. Virus-specific cytotoxic T lymphocytes of a given donor were found to recognize all HLA-A3-matched target cells, including target cells of a donor from whom the virus-specific effector cells did not recognize target cells of that given donor: Donor A recognizes target B but donor B does not recognize target A. Both will recognize a third HLA-A3-matched target cell C. Cold target inhibition studies confirmed that the recognition of target cell B by effector cell A involved the recognition of only HLA-A3. Examples of such asymmetric recognition were found in both influenza A and Epstein-Barr virus-specific cytotoxic T-lymphocyte responses but not one combination was asymmetric in both systems. This suggests that influenza virus A/HK-specific cytotoxic T lymphocytes recognize other HLA-A3 histotopes than do Epstein-Barr virus-specific cytotoxic T lymphocytes.
Van Dijk
J
J
Uyldert
A W
AW
Lucas
C J
CJ
D006680:HLA Antigens / Q000276:immunology*; D015791:HLA-A3 Antigen; D004854:Herpesvirus 4, Human / Q000502:physiology; D006650:Histocompatibility Testing; D006801:Humans; D009975:Orthomyxoviridae / Q000502:physiology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000382:microbiology
D006680:HLA Antigens; D015791:HLA-A3 Antigen