[EDLS (endogenous digitalis-like substance(s))--detection, chemistry, and physiologic function].
Human beings and higher animals contain compounds which interact with the Na+/K+-ATPase of the heart muscle and other organs like the cardiac glycosides, and bind to cardiac glycoside-specific antibodies [endogenous digitalis-like substance(s), EDLS]. EDLS cause increased natriuresis. The level of EDLS of the blood is raised under physiological stress situations (e.g., pregnancy and delivery and at certain pathophysiological conditions (e.g., hypertony). The EDLS are low molecular compounds. As yet their chemical structure is unknown.
Fürst
B
B
Martin-Luther-Universität, Sektion Pharmazie, Halle, Saale.
Luckner
M
M
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D001798:Blood Proteins / Q000032:analysis / Q000502:physiology*; D002298:Cardenolides; D004077:Digoxin; D006801:Humans; D012503:Saponins
D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D000251:Adenosine Triphosphatases
EDLS [Endogenous digitalis-like substance(s)]--Nachweis, Chemie, physiologische Bedeutung.