title: Individual tumors of multifocal EB virus-induced malignant lymphomas in tamarins arise from different B-cell clones.
abstract: Cotton-top tamarins were inoculated with sufficient Epstein-Barr virus to induce multiple tumors in each animal within 14 to 21 days. The tumors consisted of large-cell lymphomas that contained multiple copies of the Epstein-Barr virus genome and generated Epstein-Barr virus-carrying cell lines showing no detectable consistent chromosomal abnormality. Hybridization of tumor DNA with immunoglobulin gene probes revealed that each lymphoma was oligo- or monoclonal in origin and that individual tumors from the same animal arose from different B-cell clones. Thus the virus induced multiple transformation events in tamarins in vivo to cause malignant tumors resembling the Epstein-Barr virus-associated lymphomas of patients with organ transplants.
authors.forename: M L
authors.initials: ML
authors.lastname: Cleary
authors.forename: M A
authors.initials: MA
authors.lastname: Epstein
authors.forename: S
authors.initials: S
authors.lastname: Finerty
authors.forename: R F
authors.initials: RF
authors.lastname: Dorfman
authors.forename: G W
authors.initials: GW
authors.lastname: Bornkamm
authors.forename: J K
authors.initials: JK
authors.lastname: Kirkwood
authors.forename: A J
authors.initials: AJ
authors.lastname: Morgan
authors.forename: J
authors.initials: J
authors.lastname: Sklar
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000382:microbiology*; D002051:Burkitt Lymphoma / Q000235:genetics / Q000382:microbiology*; D002460:Cell Line; D004273:DNA, Neoplasm / Q000235:genetics; D016027:Heart Transplantation; D004854:Herpesvirus 4, Human; D006801:Humans; D009374:Neoplasms, Experimental / Q000235:genetics / Q000382:microbiology; D009693:Nucleic Acid Hybridization; D012452:Saguinus
chemical_list: D004273:DNA, Neoplasm