Supine and sitting maximal workload difference and response to long-term enalapril therapy in congestive heart failure.
Maximal workloads in supine and sitting bicycle stress tests were compared in 12 patients with congestive heart failure during long-term therapy with the vasodilator enalapril. The response to the therapy was observed with the supine and sitting bicycle stress tests and gated equilibrium ventriculography. The maximal workload was 68 W in the supine position and 84 W in the sitting position; the mean difference was 15 W. The difference was highly significant (P less than 0.001). Both the supine and sitting workloads were significantly higher (P less than 0.02 and P less than 0.05) in the enalapril group than in the placebo group. The findings in the gated equilibrium ventriculography were not significantly different between the two groups.
Pöyhönen
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D000368:Aged; D002986:Clinical Trials as Topic; D004151:Dipeptides / Q000627:therapeutic use*; D004311:Double-Blind Method; D004656:Enalapril; D005080:Exercise Test; D006321:Heart / Q000000981:diagnostic imaging; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D005082:Physical Exertion; D011187:Posture; D011877:Radionuclide Imaging; D011897:Random Allocation; D013997:Time Factors; D014665:Vasodilator Agents / Q000627:therapeutic use*
D004151:Dipeptides; D014665:Vasodilator Agents; D004656:Enalapril