title: Classification of the insulin-like growth factor binding proteins into three distinct categories according to their binding specificities.
abstract: Competitive binding experiments with insulin-like growth factor (IGF)-1, IGF-2 and des-(1-3)-IGF-1 have confirmed the interpretation based on limited amino-terminal sequence analysis that at least three types of IGF binding protein occur. In addition to the acid stable subunit of the large serum binding protein which exhibits des-(1-3)-IGF-1 binding only slightly less than IGF-1, the small IGF binding proteins can be separated into two classes based on differences in des-(1-3)-IGF-1 and IGF-2 binding potencies.
authors.affiliation: Department of Biochemistry, University of Adelaide, Australia.
authors.forename: B
authors.initials: B
authors.lastname: Forbes
authors.forename: L
authors.initials: L
authors.lastname: Szabo
authors.forename: R C
authors.initials: RC
authors.lastname: Baxter
authors.forename: F J
authors.initials: FJ
authors.lastname: Ballard
authors.forename: J C
authors.initials: JC
authors.lastname: Wallace
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D002417:Cattle; D002460:Cell Line; D006801:Humans; D007668:Kidney / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D011972:Receptor, Insulin / Q000145:classification* / Q000378:metabolism; D017451:Receptors, Somatomedin; D011994:Recombinant Proteins / Q000378:metabolism; D013002:Somatomedins / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D010446:Peptide Fragments; D017451:Receptors, Somatomedin; D011994:Recombinant Proteins; D013002:Somatomedins; D011972:Receptor, Insulin