title: Fixed drug eruptions--a Singapore study.
abstract: This study documents 62 patients with fixed drug eruptions (FDE) proven by provocative testing. Of these 39 (63%) were caused by tetracycline hydrochloride and 12 (19%) caused by Saridon (R). Fifty-eight (94%) of the patients had 10 or less lesions and 50 (81%) had 5 or less lesions. The lips and genitalia were preferential sites being involved in 28 (45%) and 22 (36%) instances. In 6 instances each a solitary lesion occurred on the lower lip or the glans penis. At presentation, 43 (69%) patients were unaware of the drug-induced nature of their condition. Compared with previous reports the causative drugs varied from place to place and from decade to decade. This may be due to differences in prescription patterns.
authors.affiliation: Department of Medicine, National University Hospital, Singapore.
authors.forename: H L
authors.initials: HL
authors.lastname: Chan
authors.forename: S N
authors.initials: SN
authors.lastname: Wong
authors.forename: S N
authors.initials: SN
authors.lastname: Tham
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012846:Singapore; D013752:Tetracycline / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013752:Tetracycline