title: Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.
abstract: We have cloned and determined the entire nucleotide sequence of cDNAs corresponding to the putative alpha subunits of the human and rat mast cell high-affinity IgE receptors. Both human and rat cDNAs encode an NH2-terminal signal peptide, two immunoglobulin-like extracellular domains (encoded by discrete exons), a hydrophobic transmembrane region, and a positively charged cytoplasmic tail. The human and rat alpha subunits share an overall homology with one another and the immunoglobulin gene family, suggesting that they arose from a common ancestral gene and continue to share structural homology with their ligands. In addition, the rat gene is transcribed into at least three distinct forms, each of which yields a somewhat different coding sequence.
authors.affiliation: Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115.
authors.forename: A
authors.initials: A
authors.lastname: Shimizu
authors.forename: I
authors.initials: I
authors.lastname: Tepler
authors.forename: P N
authors.initials: PN
authors.lastname: Benfey
authors.forename: E H
authors.initials: EH
authors.lastname: Berenstein
authors.forename: R P
authors.initials: RP
authors.lastname: Siraganian
authors.forename: P
authors.initials: P
authors.lastname: Leder
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000378:metabolism; D006801:Humans; D008407:Mast Cells / Q000378:metabolism*; D008969:Molecular Sequence Data; D010449:Peptide Mapping; D051381:Rats; D011961:Receptors, Fc / Q000378:metabolism*; D017455:Receptors, IgE
chemical_list: D011961:Receptors, Fc; D017455:Receptors, IgE; D004247:DNA