title: Effect of chronic administration of acetaldehyde by inhalation on (Na+ + K+)-activated adenosine triphosphatase activity of rat brain membranes.
abstract: The effect of chronic acetaldehyde inhalation on (Na+ + K+)-ATPase (EC 3.6.1.3) activities of subcellular fractions of the rat cerebral cortex was studied. Chronic administration of acetaldehyde by inhalation for 4-21 weeks caused significant increases in the enzyme activities of both the synaptosomal plasma membrane (SPM) fraction and the microsomal (MC) fraction. This indicates the change in neural membrane functions of the brain after acetaldehyde treatment. Mg2+-ATPase activities of both subcellular fractions remained unchanged after acetaldehyde treatment.
authors.forename: E
authors.initials: E
authors.lastname: Shiohara
authors.forename: M
authors.initials: M
authors.lastname: Tsukada
authors.forename: S
authors.initials: S
authors.lastname: Chiba
authors.forename: H
authors.initials: H
authors.lastname: Yamazaki
authors.forename: K
authors.initials: K
authors.lastname: Nishiguchi
authors.forename: R
authors.initials: R
authors.lastname: Miyamoto
authors.forename: S
authors.initials: S
authors.lastname: Nakanishi
mesh_terms: D000079:Acetaldehyde / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D005740:Gases; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013347:Subcellular Fractions / Q000201:enzymology; D013997:Time Factors
chemical_list: D005740:Gases; D000254:Sodium-Potassium-Exchanging ATPase; D000079:Acetaldehyde