title: The role of the leucine zipper in the fos-jun interaction.
abstract: Mutagenesis of the fos protein supports the hypothesis that a heptad repeat of leucine residues stabilizes the interaction between the fos and jun proteins. We show that the complex between fos and jun can bind to DNA more tightly than either protein alone and that basic residues adjacent to the leucine repeat of fos contribute to the DNA-binding potential of the complex.
authors.affiliation: Department of Biochemistry, New York University Medical Center, New York 10016.
authors.forename: T
authors.initials: T
authors.lastname: Kouzarides
authors.forename: E
authors.initials: E
authors.lastname: Ziff
mesh_terms: D000818:Animals; D010582:Bacteriophage lambda / Q000378:metabolism; D001665:Binding Sites; D004247:DNA / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D066298:In Vitro Techniques; D007930:Leucine / Q000502:physiology*; D009154:Mutation; D009841:Oligonucleotides / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D016271:Proto-Oncogene Proteins c-myc; D011817:Rabbits; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D009841:Oligonucleotides; D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors; D004247:DNA; D007930:Leucine