[Immunogenicity of a hepatitis B vaccine obtained by genetic recombination and containing products of S and pre-S2 genes].
Immunization against hepatitis B by means of a vaccine obtained by genetic recombination on chinese hamster ovary cells was attempted in 32 adult subjects. The HBs antigen was purified from the culture supernatant and contained S and pre S2 genes products. Three 20 micrograms doses were injected intramuscularly at intervals of one month. Anti-HBs seroconversion levels and the geometrical mean of antibodies were slightly higher than those observed with plasma vaccines or genetically engineered yeast-derived vaccine. Antibodies directed against HBs appeared more rapidly and at a higher titre. Anti-pre S2 antibodies were detected after the third injection in 84 per cent of the subjects vaccinated. This recombinant hepatitis B vaccine prepared from chinese hamster ovary cells will probably be as effective as the first generation vaccines obtained by purifying the HBs antigen obtained from the blood of asymptomatic carriers.
Coursaget
P
P
Institut de Virologie de Tours, Facultés de Médecine et de Pharmacie.
Yvonnet
B
B
Anthonioz
P
P
Chotard
J
J
Bourdil
C
C
Adamowicz
P
P
Tron
F
F
Girard
M
M
D000328:Adult; D005260:Female; D005814:Genes, Viral; D006510:Hepatitis B Antibodies / Q000032:analysis; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D011995:Recombination, Genetic; D014765:Viral Vaccines / Q000276:immunology*
D006510:Hepatitis B Antibodies; D014765:Viral Vaccines
Immunogénicité d'un vaccin contre l'hépatite B obtenu par recombinaison génétique et contenant les produits des gènes S et pré S2.