Lung tumor imaging by positron emission tomography using C-11 L-methionine.
This paper described the first clinical study of lung tumor scanning by positron emission tomography (PET) using C-11-labeled L-methionine (11C-L-Met). Tumor images were clearly visualized by high contrast in eight lung cancer patients and also in a patient with a silicotic nodule. Quantitative evaluations of methionine uptake in tumor tissue and normal tissue by comparing differential uptake ratios suggested that the extent to which 11C-L-Met accumulates in a tumor is closely correlated to the tumor's viability such as benign or malignant, viable or necrotic. 11C-L-Met is considered to be an effective tumor marker for PET diagnosis which represents increased amino acid metabolism of tumors in the mediastinum and lung.
Kubota
K
K
Matsuzawa
T
T
Ito
M
M
Ito
K
K
Fujiwara
T
T
Abe
Y
Y
Yoshioka
S
S
Fukuda
H
H
Hatazawa
J
J
Iwata
R
R
D002250:Carbon Radioisotopes; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008715:Methionine; D012829:Silicosis / Q000000981:diagnostic imaging; D014055:Tomography, Emission-Computed; D014375:Tuberculoma / Q000000981:diagnostic imaging
D002250:Carbon Radioisotopes; D008715:Methionine