Ventricular myosin of the shrew Crocidura russula, correlation with contractile properties.
The present study demonstrates that in the shrew ventricular muscle the speed of tension development and relaxation, as well as twitch duration, are much shorter than in the guinea-pig. It also shows that ventricular myosin of the shrew has a high Ca2+-activated ATPase activity and that it is composed of alpha-type heavy chains. Namely, the native molecule is a V1 variety of myosin. These findings advance our knowledge on an as yet uncharacterized mammalian heart and further demonstrate the correlation between mechanical properties and myosin type in heart muscle.
Kessler-Icekson
G
G
Rogoff Medical Research Institute, Beilinson Medical Center, Petah Tikva, Israel.
Schlesinger
H
H
Leger
J J
JJ
Leger
J
J
Braverman
Y
Y
Binah
O
O
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009200:Myocardial Contraction; D015879:Myosin Subfragments; D009218:Myosins / Q000302:isolation & purification / Q000378:metabolism*; D010446:Peptide Fragments / Q000302:isolation & purification / Q000378:metabolism; D012788:Shrews / Q000502:physiology*; D013045:Species Specificity; D016276:Ventricular Function
D015879:Myosin Subfragments; D010446:Peptide Fragments; D009218:Myosins; D000252:Calcium-Transporting ATPases