Fused transcript of abl and bcr genes in chronic myelogenous leukaemia.
Human chronic myelogenous leukaemia is characterized by a reciprocal translocation between chromosomes 9 and 22 resulting in an abbreviated form of chromosome 22 and the transfer of the abl cellular oncogene from chromosome 9 into the bcr gene of chromosome 22. Characterization of an 8-kilobase RNA specific to chronic myelogenous leukaemia shows it to be a fused transcript of the two genes. The fused protein that would be produced is probably involved in the malignant process.
Shtivelman
E
E
Lifshitz
B
B
Gale
R P
RP
Canaani
E
E
D001483:Base Sequence; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D014158:Transcription, Genetic
D004273:DNA, Neoplasm; D004262:DNA Restriction Enzymes