T cell subsets in patients with systemic lupus erythematosus.
T cell subsets were determined in blood of 16 patients with systemic lupus erythematosus (SLE), and 16 healthy individuals. SLE patients showed marked decrease in relative level of suppressor/cytotoxic T cells, slight decrease in helper/inducer T cells, and an increased helper/suppressor T cell ratio. The diminished level of suppressor/cytotoxic T cells was correlated with the clinical severity of disease. Cytofluorographic analysis of T cell subsets obtained from SLE patients did not show significant differences in homogeneity of the cell subpopulations as compared to healthy controls.
Kucharz
E J
EJ
Medical College of Wisconsin, Department of Medicine, Milwaukee 53226.
Sierakowski
S J
SJ
D002469:Cell Separation; D005434:Flow Cytometry; D006801:Humans; D007958:Leukocyte Count; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*