[Experimental immunopharmacology of RU 41740].
RU 41740 is a biological immunomodulator which stimulates phagocytic cells, mostly by increasing their functional activities: cell metabolism, chemotaxis and secretion of mediators, notably interleukine 1. This compound also stimulates cellular immunity, as shown by the increase observed in proliferative responses in vitro, cell-mediated lymphocytotoxicity and natural killer cell-dependent cytotoxicity. Finally, RU 41740 stimulated B cells through a mitogenic effect and through a non-specific increase in antibody secretion.
Boissier
M C
MC
Unité de Recherches sur la Pathologie autoimmune (Inserm U.283), Hôpital Cochin, Paris.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001426:Bacterial Proteins / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007378:Interleukins / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000187:drug effects; D051379:Mice; D010586:Phagocytes / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects*
D000276:Adjuvants, Immunologic; D001426:Bacterial Proteins; D007378:Interleukins; C037567:glycoprotein, Klebsiella pneumoniae
Immunopharmacologie expérimentale du RU 41740.