The effect of halofuginone on the excretion of Salmonella typhimurium by experimentally infected chickens.
The effect of feeding halofuginone at 3 and 6 ppm on the excretion of Salmonella typhimurium by experimentally infected chickens was studied. A standardized procedure was used involving the oral inoculation of 72-h-old specific pathogen-free chickens with 10(8) organisms of a nalidixic acid-resistant mutant of a strain of S. typhimurium. At weekly intervals, cloacal swabs were taken and a semi-quantitative assessment was made of the numbers of Salmonella organisms excreted. When compared with the control group of infected chickens fed unmedicated food, the group fed halofuginone at 3 ppm showed no significant increase in excretion rate. The group fed 6 ppm showed a slight increase in excretion which was statistically significant.
Barrow
P A
PA
Houghton Poultry Research Station, Huntingdon, Cambridgeshire, Gt. Britain.
Simpson
J M
JM
Kirk
S J
SJ
Baker
M N
MN
D000821:Animal Feed; D000818:Animals; D002645:Chickens; D003049:Coccidiostats / Q000494:pharmacology / Q000627:therapeutic use*; D015169:Colony Count, Microbial / Q000662:veterinary; D005243:Feces / Q000382:microbiology; D010880:Piperidines; D011201:Poultry Diseases / Q000209:etiology*; D011799:Quinazolines / Q000494:pharmacology / Q000627:therapeutic use*; D052999:Quinazolinones; D012481:Salmonella Infections, Animal / Q000209:etiology*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000254:growth & development; D013047:Specific Pathogen-Free Organisms
D003049:Coccidiostats; D010880:Piperidines; D011799:Quinazolines; D052999:Quinazolinones; C010176:halofuginone