Immunodeficiency and prognosis in patients with non-Hodgkin's lymphomas.
Monocyte depleted blood lymphocyte subpopulations, their functions and relation to prognosis were studied in 68 untreated adult patients with non-Hodgkin's lymphomas classified according to the Kiel nomenclature. The median observation time was 48 months (range 41-60). The mean total blood lymphocyte and T (SRBC-rosetting) cell counts were significantly decreased as compared with age-matched controls (n = 57). Twenty-five per cent of the patients had a monoclonal blood B lymphocyte population. The spontaneous lymphocyte DNA synthesis, measured as incorporation of 14C-thymidine, was increased and the response to mitogen and antigen stimulation was decreased. Blood lymphocyte counts and functions before treatment were not related to the rates of remission or survival.
Lindemalm
C
C
Biberfeld
P
P
Björkholm
M
M
Holm
G
G
Johansson
B
B
Mellstedt
H
H
Nilsson
B
B
Ost
A
A
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed; D007108:Immune Tolerance; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008223:Lymphoma / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis