title: Oral rehydration therapy without bicarbonate for prevention and treatment of dehydration: a double-blind controlled trial.
abstract: Forty children (less than or equal to 2 years of age) were admitted to hospital with acute gastroenteritis and were randomly assigned to receive either an oral rehydration solution (ORS) containing bicarbonate (Na 35, K 20, Cl 37, HCO3 18, glucose 202 mmol litre-1) or an identical solution in which bicarbonate was replaced by chloride ions. Groups were matched for age, sex, ethnic origin, duration of diarrhoea and nutritional status. On admission, degree of dehydration, biochemical and haematological parameters were similar. The majority had minimal or no dehydration and only 30% had moderate to severe dehydration. All children were treated successfully with no complications. Oral rehydration solution intake by each group was similar. Clinical outcome, as judged by speed of rehydration or maintenance of hydration, duration of diarrhoea, stool frequency and length of hospital stay, was the same in both groups. After 24 h of ORS there was no difference between groups in venous pH, serum bicarbonate, urea and electrolytes. In hospitalized children with acute gastroenteritis in the United Kingdom an ORS without bicarbonate is a safe, effective means to prevent dehydration and maintain hydration and acid-base status where dehydration is not severe. Exclusion of bicarbonate would simplify production, increase stability and reduce the cost of ORS without apparent impairment of efficacy.
authors.affiliation: Academic Department of Child Health, Queen Elizabeth Hospital for Children, London, UK.
authors.forename: E J
authors.initials: EJ
authors.lastname: Elliott
authors.forename: J C
authors.initials: JC
authors.lastname: Armitstead
authors.forename: M J
authors.initials: MJ
authors.lastname: Farthing
authors.forename: J A
authors.initials: JA
authors.lastname: Walker-Smith
mesh_terms: D000138:Acidosis / Q000188:drug therapy; D001639:Bicarbonates / Q000627:therapeutic use; D002675:Child, Preschool; D003681:Dehydration / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D004311:Double-Blind Method; D005440:Fluid Therapy; D005759:Gastroenteritis / Q000150:complications; D006801:Humans; D007223:Infant
chemical_list: D001639:Bicarbonates