Development of the rat pineal alpha 1-adrenoceptor.
Pineal alpha 1-adrenoceptors in rats from 19 days of gestation until 11 months of age were studied using [125I]iodo-2-[beta-(4-hydroxyphenyl)ethylaminomethyl]tetralone ( [125I]HEAT). The number of specific [125I]HEAT binding sites increased markedly between 18 days of gestation (101.7 +/- 13.1 fmol/mg protein) and 10 days of age (336.2 +/- 34.3 fmol/mg protein). A significant decline occurred after 1 month of age. A saturation study showed similar changes in receptor density with age (Bmax; 20 days of gestation, 130.5 fmol/mg protein; 35 days old, 288.1 fmol/mg protein) but no difference in Kd (58.4 pM at both -1 and +35 days). The developmental appearance of the pineal alpha 1-adrenoceptor and the decline in its density with age are remarkably similar to changes reported for pineal beta-adrenoceptors.
Sugden
D
D
Klein
D C
DC
D000818:Animals; D010870:Pineal Gland / Q000196:embryology / Q000254:growth & development*; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta