title: [Protective action of nicotinamide and pyridoxine on the initiation stage of carcinogenesis induced in mice by procarbazine].
abstract: It is shown that at the initiating stage of procarbazine carcinogenesis in F1 female mice the parenteral administration of nicotinamide or pyridoxine results in a significant decrease in the lung adenoma rate from 77% to 18 or 46%, respectively. Pyridoxal, pyridoxal-5'-phosphate and L-penicillamine did not influence the lung adenoma frequency.
authors.forename: T V
authors.initials: TV
authors.lastname: Nikonova
authors.forename: V A
authors.initials: VA
authors.lastname: Draudin-Krylenko
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Bukin
authors.forename: V S
authors.initials: VS
authors.lastname: Turusov
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D009536:Niacinamide / Q000627:therapeutic use*; D010396:Penicillamine / Q000627:therapeutic use; D011344:Procarbazine / Q000633:toxicity*; D011736:Pyridoxine / Q000627:therapeutic use*
chemical_list: D009536:Niacinamide; D011344:Procarbazine; D010396:Penicillamine; D011736:Pyridoxine
vernacular_title: Zashchitnoe deĭstvie nikotinamida i piridoksina na stadii initsiatsii kantserogeneza, vyzvvaemogo u mysheĭ prokarbazinom.