A comparison between two commercially available activators for determining the partial thromboplastin time.
Activators that are used to determine the activated partial thromboplastin time should be sensitive enough to detect mild deficiencies of coagulation factors in a reproducible fashion. We compared two commercially available activators--a newly modified preparation of ellagic acid activator and a silica activator. Both reagents produced results that were reproducible over a broad range of concentrations of factors involved in the intrinsic coagulation pathway. The ellagic acid activator was more sensitive in detecting a partial deficiency of nearly all of these factors.
Smith
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Kitchens
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D000328:Adult; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D004610:Ellagic Acid; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D012822:Silicon Dioxide
D001779:Blood Coagulation Factors; D004610:Ellagic Acid; D012822:Silicon Dioxide