title: Mechanism of skin allograft enhancement across an H-2 class I mutant difference. Evidence for involvement of veto cells.
abstract: Intravenous injection of spleen cells across mutant class I H-2 incompatibility results in a drastic donor-specific prolongation of skin allograft survival and a marked decrease in the donor-specific cytotoxic T lymphocyte precursor (CTLp) frequency. This immunosuppressive effect depends on the presence of radiosensitive T cells in the donor cell inoculum. It was excluded that a graft-vs.-host reaction was responsible for the observed effects. In mixing experiments, spleen cells from animals transfused with allogeneic lymphocytes could not suppress a normal CTL response against the alloantigen, despite an excess of putative recipient-derived spleen suppressor cells. The data are compatible with the idea that donor T cells function as veto cells which inactivate recipient CTLp directed against the alloantigen expressed by the veto cell.
authors.affiliation: Central Laboratory of the Netherlands, Red Cross Blood Transfusion Service.
authors.forename: W M
authors.initials: WM
authors.lastname: Kast
authors.forename: E
authors.initials: E
authors.lastname: Van Twuyver
authors.forename: R J
authors.initials: RJ
authors.lastname: Mooijaart
authors.forename: M
authors.initials: M
authors.lastname: Verveld
authors.forename: A G
authors.initials: AG
authors.lastname: Kamphuis
authors.forename: C J
authors.initials: CJ
authors.lastname: Melief
authors.forename: L P
authors.initials: LP
authors.lastname: De Waal
mesh_terms: D000818:Animals; D001803:Blood Transfusion; D002470:Cell Survival / Q000528:radiation effects; D006183:H-2 Antigens / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy / Q000379:methods*; D051379:Mice; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D006183:H-2 Antigens