title: Cervical cancer risk and use of depot-medroxyprogesterone acetate in Costa Rica.
abstract: The relationship between cervical cancer and the use of depot-medroxyprogesterone acetate (DMPA) was examined in a nationwide case-control study in Costa Rica. Cases were women ages 25-58 years of age with invasive squamous cell cancer (N = 149) or carcinoma in situ (CIS, N = 415) reported by the National Tumor Registry during 1982-84. Controls (N = 764) were randomly selected during a nationwide household survey. Using logistic regression, we adjusted for known risk factors for cervical cancer. DMPA use was associated with a risk of CIS of 1.1 (95% confidence interval 0.6-1.8) and a risk of invasive cancer of 1.4 (95% confidence interval 0.6-3.1). The slightly elevated risks observed may be the result of chance or a detection bias. One limitation of this study is that few women had used DMPA for longer than two years.
authors.affiliation: Division of Reproductive Health, Centers for Disease Control, Atlanta, GA 30333.
authors.forename: M W
authors.initials: MW
authors.lastname: Oberle
authors.forename: L
authors.initials: L
authors.lastname: Rosero-Bixby
authors.forename: K L
authors.initials: KL
authors.lastname: Irwin
authors.forename: J A
authors.initials: JA
authors.lastname: Fortney
authors.forename: N C
authors.initials: NC
authors.lastname: Lee
authors.forename: A S
authors.initials: AS
authors.lastname: Whatley
authors.forename: M G
authors.initials: MG
authors.lastname: Bonhomme
mesh_terms: D000328:Adult; D002278:Carcinoma in Situ / Q000139:chemically induced* / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000453:epidemiology; D003271:Contraceptive Agents, Female / Q000009:adverse effects*; D003364:Costa Rica; D005260:Female; D006801:Humans; D008525:Medroxyprogesterone / Q000009:adverse effects / Q000031:analogs & derivatives*; D017258:Medroxyprogesterone Acetate; D008875:Middle Aged; D012044:Regression Analysis; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced* / Q000453:epidemiology
chemical_list: D003271:Contraceptive Agents, Female; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone