Transferrin receptor expression by stimulated cells in mixed lymphocyte culture.
Transferrin receptor (TRFr) expression by cells in mixed lymphocyte culture increases steadily for the first 5 days, but then reaches a plateau. By the sixth day in culture, about 20% of viable cells express TRFr in two-way mixed lymphocyte reactions. This subpopulation of TRFr-positive cells represents the proliferating population; it is heterogeneous, containing T-cell blasts and smaller cells which are a mixture of T and non-T cells. A small group of non-T cells have phenotypic similarity to natural killer (NK) cells. T cells appear to divide earlier in the course of the response than non-T cells. The biphasic nature of this response and the slower non-T reactivity may be due to a secondary stimulation of non-T cells by factors released from activated T cells (such as interleukin-2).
Salmon
M
M
Bacon
P A
PA
Symmons
D P
DP
Walton
K W
KW
D000954:Antigens, Surface / Q000276:immunology; D002478:Cells, Cultured; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D008938:Mitosis; D011956:Receptors, Cell Surface / Q000276:immunology*; D011990:Receptors, Transferrin; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D014168:Transferrin / Q000276:immunology*
D000954:Antigens, Surface; D007376:Interleukin-2; D011956:Receptors, Cell Surface; D011990:Receptors, Transferrin; D014168:Transferrin