Astrocyte opioid receptors: activation modifies the noradrenaline-evoked increase in 2-[14C]deoxyglucose incorporation into glycogen.
Astrocyte-enriched cultures of the newborn rat cortex accumulated 2-[14C]deoxyglucose (2-DG), a proportion portion of which was incorporated into glycogen. Exposure to exogenous noradrenaline resulted in an increase (30%) in the incorporation of 2-[14C]DG into glycogen in these cultures. The extent to which noradrenaline evoked an increase in 2-[14C]DG labelling of glycogen was modified by both morphine and methionine-enkephalin. Whereas morphine augmented the noradrenaline-induced increase in 2-[14C]DG incorporation into glycogen in these cultures, methionine-enkephalin attenuated this response.
Pearce
B
B
Cambray-Deakin
M
M
Murphy
S
S
D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000187:drug effects* / Q000378:metabolism; D002478:Cells, Cultured; D002540:Cerebral Cortex; D004347:Drug Interactions; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D006003:Glycogen / Q000096:biosynthesis; D009020:Morphine / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects*
D011957:Receptors, Opioid; D004744:Enkephalin, Methionine; D009020:Morphine; D006003:Glycogen; D005947:Glucose; D009638:Norepinephrine