Suppression of immune-mediated otitis media by T-suppressor cells.
Effects of mucosa-derived T-suppressor cells on induction of IgG-mediated otitis media with effusion (OME) were investigated in mice, since antigen-antibody reactions in the tympanic cavity are pathogenic mechanisms of OME. Splenic T-suppressor cells from strain C3H/HeN female mice, to which ovalbumin (OVA) had been orally administered, were transferred intravenously to syngeneic mice. The mice receiving the T-suppressor cells were immunized with OVA intraperitoneally and then injected with OVA into the tympanic cavity. Nine of ten control mice, to which splenic T cells from saline-fed mice were administered, developed OME, while OME was seen in only one of ten mice receiving splenic T cells from OVA-fed mice. The results show that IgG-mediated OME can be suppressed to a certain extent by the induction of antigen-specific, mucosa-derived, T-suppressor cells.
Ueyama
S
S
Department of Otolaryngology, Medical College of Oita, Japan.
Kawauchi
H
H
Mogi
G
G
D000818:Animals; D005260:Female; D007114:Immunization; D007074:Immunoglobulin G / Q000276:immunology; D007167:Immunotherapy; D051379:Mice; D008809:Mice, Inbred C3H; D010034:Otitis Media with Effusion / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D010581:Peyer's Patches / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D007074:Immunoglobulin G