title: Mutual inhibitory effect of calpastatins on calpains from carp muscle, carp erythrocytes and rat liver.
abstract: The inhibitory effect of calpastatin (specific inhibitor for calpain) on calpain (Ca2+-dependent cysteine proteinase, EC 3.4.22.17) was examined using carp muscle, carp erythrocytes and rat liver preparations. A mutual inhibitory effect between calpains and calpastatins from different tissues and species was observed. The conservation of the inhibitory effect of calpastatin on calpain among vertebrates suggests that the calpain-calpastatin system may play a biologically fundamental and common role in various cells.
authors.forename: H
authors.initials: H
authors.lastname: Toyohara
authors.forename: Y
authors.initials: Y
authors.lastname: Makinodan
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000494:pharmacology*; D002154:Calpain; D002347:Carps; D004912:Erythrocytes / Q000201:enzymology*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D009132:Muscles / Q000201:enzymology*; D009928:Organ Specificity; D011480:Protease Inhibitors / Q000494:pharmacology*; D051381:Rats; D013045:Species Specificity
chemical_list: D002135:Calcium-Binding Proteins; D011480:Protease Inhibitors; C033668:calpastatin; D002154:Calpain