[Ankylosing spondylitis with type AA amyloidosis. 6 cases].
The authors have studied 6 cases of systemic AA amyloidosis associated with ankylosing spondylitis. Renal failure occurred in all patients a mean of 19 years after the clinical onset of the rheumatic disease. Three patients progressed rapidly (between 3 months and 3 years) to end-stage renal failure. Such an outcome did not depend upon early onset of the renal impairment, degree of inflammation or treatment with colchicine. All patients were alive 2 to 10 years later, and this confirms a better prognosis than with AL amyloidosis. The utility of combining Wright's permaganate reaction with immunological methods to characterize the amyloid deposits was also confirmed. It is concluded that amyloidosis is a rare complication of ankylosing spondylitis and probably depends on a genetic predisposition. The possibility of amyloidosis should be kept in mind when proteinuria or renal failure appear in the course of ankylosing spondylitis.
Geffriaud
C
C
Département de Néphrologie, Hôpital Necker, Paris.
Noël
L H
LH
Blanche
P
P
Ganeval
D
D
Barbanel
C
C
Jungers
P
P
Grünfeld
J P
JP
D000293:Adolescent; D000328:Adult; D000686:Amyloidosis / Q000150:complications*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology*; D008297:Male; D012189:Retrospective Studies; D000685:Serum Amyloid A Protein / Q000032:analysis; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000175:diagnosis
D000685:Serum Amyloid A Protein
Spondylarthrite ankylosante avec amylose de type AA. Six observations.