[Ceftazidime on animal experimental models].
Experiments on animal models represent an important stage in the development of antibiotics. As regards ceftazidime, they have confirmed that its activity is time-dependent in vivo, that there is no post-antibiotic effect and that combining this cephalosporin with an aminoglycoside is useful in neutropenic animals, notably in case of Pseudomonas infection. The potential usefulness of ceftazidime in the treatment of meningitis has also been demonstrated. However, animal models have limited value when one tries to extrapolate to man the therapeutic results obtained. In particular, they provide no information on optimal dosage, critical concentrations or desirable duration of treatment.
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Service de Médecine interne, CHU Bichat, Paris.
D000818:Animals; D002442:Ceftazidime / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000378:metabolism*
D002442:Ceftazidime
Etudes de la ceftazidime sur les modèles expérimentaux animaux.