Increased myocardial alpha 1 adrenoceptor density in rats chronically treated with propranolol.
Chronic treatment with propranolol for 6 weeks resulted in a 16.6% increase, over the level in control rats, in myocardial alpha 1-adrenoceptor density as measured by [3H]prazosin binding. The apparent affinity remained unaffected. No changes were observed in beta-adrenoceptor density and apparent affinity as measured by [3H]dihydroalprenolol binding. It is concluded that myocardial alpha 1-adrenoceptors might have a compensatory role under conditions where beta-adrenergic effects are attenuated.
Mügge
A
A
Reupcke
C
C
Scholz
H
H
D000818:Animals; D004082:Dihydroalprenolol / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011224:Prazosin / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000187:drug effects
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D011433:Propranolol; D011224:Prazosin