title: The human gene encoding insulin-like growth factor I is located on chromosome 12.
abstract: A cDNA probe corresponding to mRNA encoding human somatomedin-C/insulin-like growth factor I (IGF-I) was used for the chromosomal assignment of the IGF-I gene. Southern-blot hybridization analysis of DNA from human-Chinese hamster somatic cell hybrids showed that the IGF-I gene is located on chromosome 12. Comparison of the chromosomal assignments of the IGF-I gene and two other members of the insulin gene family, with three c-ras oncogenes, reveals a remarkable association of the two gene families.
authors.forename: J W
authors.initials: JW
authors.lastname: Höppener
authors.forename: P
authors.initials: P
authors.lastname: de Pagter-Holthuizen
authors.forename: A H
authors.initials: AH
authors.lastname: Geurts van Kessel
authors.forename: M
authors.initials: M
authors.lastname: Jansen
authors.forename: S D
authors.initials: SD
authors.lastname: Kittur
authors.forename: S E
authors.initials: SE
authors.lastname: Antonarakis
authors.forename: C J
authors.initials: CJ
authors.lastname: Lips
authors.forename: J S
authors.initials: JS
authors.lastname: Sussenbach
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D004587:Electrophoresis, Agar Gel; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D007328:Insulin / Q000235:genetics*; D009857:Oncogenes; D010455:Peptides / Q000235:genetics*; D013002:Somatomedins / Q000235:genetics*
chemical_list: D007328:Insulin; D010455:Peptides; D013002:Somatomedins; D004247:DNA; D004262:DNA Restriction Enzymes