Failure of a dengue 1 sub-unit vaccine to protect mice against a lethal dengue virus infection.
Mice immunized with DEN-1 pre-matrix protein produced antibody which reacted with dengue virus infected cells and intact virions but failed to neutralize virus in vitro or in vivo. Newborn mice passively immunized with anti-DEN-1 pre-matrix antibody also failed to survive intracerebral infection with 100 LD50 of any dengue virus serotype.
Aaskov
J G
JG
Department of Medical Laboratory Science, Queensland Institute of Technology, Brisbane, Australia.
Williams
L
L
Fletcher
J
J
Hay
R
R
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000276:immunology; D015153:Blotting, Western; D002213:Capsid / Q000276:immunology; D003715:Dengue / Q000517:prevention & control*; D003716:Dengue Virus / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D007112:Immunity, Maternally-Acquired; D007116:Immunization, Passive; D051379:Mice; D008807:Mice, Inbred BALB C; D013047:Specific Pathogen-Free Organisms; D014764:Viral Proteins / Q000276:immunology*; D014765:Viral Vaccines
D000914:Antibodies, Viral; D014764:Viral Proteins; D014765:Viral Vaccines