Hormonotherapy of meningiomas with medroxyprogesterone acetate. Immunohistochemical demonstration of the effect of medroxyprogesterone acetate on growth fractions of meningioma cells using the monoclonal antibody Ki-67.
The effect of medroxyprogesterone acetate (MPA) on growth fractions of ex vivo meningiomas is demonstrated in using the Ki-67 monoclonal antibody in three cases of meningiomas operated on in two stages and in meningioma specimens from a group of eight patients operated on in one single stage after MPA therapy. Growth fractions in samples from five meningioma patients not treated with MPA were determined for comparison. In the three cases of two-stage operation of the tumors, the percentage of Ki-67-positive cells in meningioma tissue was lower by a factor of 6, 5, and 3, respectively, after MPA therapy. In meningioma specimens from patients receiving no MPA therapy, Ki-67-positive cells were present in 1.02 +/- 0.48%; in samples from MPA-treated tumors the percentage of Ki-67-positive cells was 0.41 +/- 0.40 (different at p less than 0.02 [Wilcoxon's test]). In comparison to our previously published data on untreated meningiomas analyzed for progesterone receptors (PR), MPA significantly reduced the PR activity. There was no obvious correlation between PR activity and potential suppression of the tumor growth fraction. It is concluded that MPA is attractive because it reduces the growth fractions of most meningiomas and might be suitable for adjuvant hormonotherapy.
Markwalder
T M
TM
Department of Neurosurgery, University of Bern, Switzerland.
Gerber
H A
HA
Waelti
E
E
Schaffner
T
T
Markwalder
R V
RV
D000911:Antibodies, Monoclonal; D004341:Drug Evaluation; D006133:Growth Substances / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017258:Medroxyprogesterone Acetate; D008577:Meningeal Neoplasms / Q000032:analysis / Q000188:drug therapy* / Q000378:metabolism; D008579:Meningioma / Q000032:analysis / Q000188:drug therapy* / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D011300:Preoperative Care; D011980:Receptors, Progesterone / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D012086:Reoperation; D013997:Time Factors; D015291:Transforming Growth Factors
D000911:Antibodies, Monoclonal; D006133:Growth Substances; D009363:Neoplasm Proteins; D010455:Peptides; D011980:Receptors, Progesterone; D015291:Transforming Growth Factors; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone