[Mathematical modeling of the dynamics of postradiation injury and recovery of intestinal epithelium].
A mathematical model for the dynamics of the crypt-villus system in irradiated mammals has been developed. The model involves a chalones mechanism of regulation crypt cell reproduction rate and represents a system of four nonlinear differential equations. The simulation results are in a good agreement with the experimental data obtained within a wide range of doses.
Smirnova
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OA
D000818:Animals; D006131:Growth Inhibitors / Q000502:physiology; D007413:Intestinal Mucosa / Q000502:physiology / Q000528:radiation effects*; D007421:Intestine, Small / Q000502:physiology / Q000528:radiation effects*; D008433:Mathematics; D051379:Mice; D008954:Models, Biological; D012038:Regeneration
D006131:Growth Inhibitors
Matematicheskoe modelirovanie dinamiki postradiatsionnogo porazheniia i vosstanovleniia kishechnogo épiteliia.