[Implication of lipid peroxidation in triethyltin poisoning in the rat].
Triethyltin intoxication induces, in vivo, a significant increase of malondialdehyde concentration in rat brain. After treatment with a Ginkgo biloba extract, an extract known to possess antiedematous and radical scavenging properties, the malondialdehyde level in the brain is significantly decreased. This suggests that a lipid peroxidation process is associated with cerebral oedema induced by triethyltin.
Boulieu
R
R
Laboratoire de Chimie biologique, Institut national des Sciences appliquées, Villeurbanne.
Munoz
J F
JF
Macovschi
O
O
Pacheco
H
H
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D001929:Brain Edema / Q000139:chemically induced* / Q000188:drug therapy; D008099:Liver / Q000032:analysis; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000097:blood; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D014220:Trialkyltin Compounds / Q000633:toxicity*; D014267:Triethyltin Compounds / Q000633:toxicity*
D010936:Plant Extracts; D014220:Trialkyltin Compounds; D014267:Triethyltin Compounds; D008315:Malondialdehyde
Implication de la peroxydation lipidique dans l'intoxication par le triéthylétain chez le rat.