Flare up of joint inflammations induced by cloned helper T cells. Retention of the helper T cells.
Joint inflammations were induced in mice by intra articular (ia) injection of cloned helper T cells specific for methylated bovine serum albumin (mBSA) together with mBSA. Local injection of mBSA several weeks after waning of a joint inflammation induced by cloned helper T cells caused a flare up reaction. This indicates that the helper T cells persisted in the joint after the primary inflammation. In the present paper we show that the helper T cells can also persist for some time in a knee joint in the absence of the specific antigen and/or an inflammatory reaction.
Klasen
I S
IS
Department of Cell Biology, Immunology and Genetics, Erasmus University Rotterdam, The Netherlands.
Ladestein
R M
RM
van den Berg
W B
WB
Benner
R
R
D000818:Animals; D001168:Arthritis / Q000276:immunology*; D002999:Clone Cells; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*