[Inhibition by ethanol and acetaldehyde the plasmin activity and plasminogen activation induced by urokinase and streptokinase].
Ethanol and in a greater degree acetaldehyde inhibit activation of plasminogen evoked by urokinase and streptokinase. Ethanol does not inhibit the plasmin caseinolytic and fibrinolytic activities though the former inhibits amidolytic activity of the enzyme but only insignificantly. Acetaldehyde inhibits the plasmin activity towards casein, fibrin and H-D-Val-Leu-Lys-pNA.
Roszkowska-Jakimiec
W
W
Zakład Analizy Instrumentalnej AM w Białymstoku.
Jurkowski
J
J
Ostrowska
H
H
Worowski
K
K
D000079:Acetaldehyde / Q000494:pharmacology*; D000933:Antifibrinolytic Agents; D000431:Ethanol / Q000494:pharmacology*; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D005342:Fibrinolysis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D010958:Plasminogen / Q000037:antagonists & inhibitors*; D015849:Plasminogen Inactivators; D013300:Streptokinase / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D014568:Urokinase-Type Plasminogen Activator / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D000933:Antifibrinolytic Agents; D015849:Plasminogen Inactivators; D000431:Ethanol; D010958:Plasminogen; D013300:Streptokinase; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator; D000079:Acetaldehyde
Hamowanie przez etanol i acetaldehyd aktywności plazminy oraz aktywacji plazminogenu przez urokinaze i streptokinaze.