Chemotherapy of experimental toxoplasmosis with special reference to robenidine.
Robenidine as an anticoccidial agent alone (in doses of 50 and 100 mg/kg) or in association with two other antiprotozoal compounds--pyrimethamine and sulfadoxine (in doses of 2.5 and 250 mg/kg, respectively) were tested in the treatment of chronically infected mice with an avirulent cyst-forming HF strain of Toxoplasma gondii. The efficacy of the used drugs was evaluated by the cysts number in the brains of treated mice versus control group, antibody level and viability of survived cysts by the consecutive infection of mice. According to these criteria none of the tested drugs alone or combined exhibited to be able to produce an effective cure of cyst-stage of toxoplasmosis in experimental mice.
Bakhtari
S K
SK
Institute of Parasitology, Czechoslovak Academy of Sciences, Ceské Budĕjovice.
Jíra
J
J
D000818:Animals; D001921:Brain / Q000469:parasitology; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D051379:Mice; D011739:Pyrimethamine / Q000008:administration & dosage / Q000627:therapeutic use; D012370:Robenidine / Q000008:administration & dosage / Q000627:therapeutic use*; D013047:Specific Pathogen-Free Organisms; D013413:Sulfadoxine / Q000008:administration & dosage / Q000627:therapeutic use; D014124:Toxoplasmosis, Animal / Q000188:drug therapy*
D006146:Guanidines; D012370:Robenidine; D013413:Sulfadoxine; D011739:Pyrimethamine