title: Prostaglandin E2 and atriopeptin III oppose the contractile effect of angiotensin II in rat kidney mesangial cell cultures.
abstract: Effects of vasoconstrictory and of dilatory hormones were studied on the contractile activity of cultured rat kidney mesangial cells. By phase contrast microscopy, a rapid contraction was seen of most cells treated with angiotensin II (10(-6) - 10(-10) mol/L), which was sometimes followed by autonomous relaxation after 10 to 20 min. Prostaglandin E2 and atriopeptin III prevented the contractile effect of angiotensin II in a dose-dependent manner. Angiotensin II, but not atriopeptin III, stimulated prostaglandin E2 synthesis in mesangial cell cultures.
authors.affiliation: Institut für Physiologie, Medizinische Universität zu Lübeck, FRG.
authors.forename: J
authors.initials: J
authors.lastname: Fandrey
authors.forename: W
authors.initials: W
authors.lastname: Jelkmann
mesh_terms: D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002478:Cells, Cultured; D015232:Dinoprostone / Q000494:pharmacology*; D005920:Glomerular Mesangium / Q000187:drug effects*; D008858:Microscopy, Phase-Contrast; D051381:Rats; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D015232:Dinoprostone