T-cell acute lymphoblastic leukemia with severe leukopenia: evidence for suppression of myeloid progenitor cells by leukemic blasts.
A patient with T-cell acute lymphoblastic leukemia presented with leukopenia due to neutropenia, no circulating blasts and normal hemoglobin level. Marrow leukemic T lymphoblasts inhibited in vitro normal CFU-GM colony growth and released an activity that stimulated normal BFU-E growth. This patient demonstrates that immature T cells may modify hematopoietic stem cell growth both in vitro and in vivo.
Douer
D
D
Institute of Hematology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Ben-Bassat
I
I
Froom
P
P
Shaked
N
N
Ramot
B
B
D000328:Adult; D001853:Bone Marrow / Q000276:immunology* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000276:immunology* / Q000473:pathology; D003114:Colony-Forming Units Assay; D003470:Culture Media; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000276:immunology* / Q000473:pathology; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology* / Q000473:pathology; D007970:Leukopenia / Q000276:immunology* / Q000473:pathology; D008297:Male; D010641:Phenotype; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology* / Q000473:pathology
D003470:Culture Media