The synthesis of protective fragments of alpha-human atrial natriuretic polypeptide (alpha-hANP).
In this paper the synthesis of alpha-human atrial natriuretic polypeptide fragments (positions, 1-4, 5-10, 11-16, 17-22, 23-28) by solution  method is reported. In the synthesis of some peptides, the results from mixed anhydride procedure and active ester procedure are compared. In the synthesis of other peptides, the effects of reaction temperature, basicity of catalyst, and reaction time on the specific rotations and yields of these compounds are observed. The sequence of amino acids of all the protective polypeptides is confirmed by FAB-MS.
Cai
M S
MS
Department of Organic Chemistry, Beijing Medical University.
Peng
S Q
SQ
Cheng
T M
TM
Dai
D H
DH
Wang
S N
SN
Li
J X
JX
Zhang
J G
JG
Cong
Y
Y
Liang
W S
WS
Wang
R
R
D009320:Atrial Natriuretic Factor / Q000138:chemical synthesis*; D008722:Methods; D010446:Peptide Fragments / Q000138:chemical synthesis*
D010446:Peptide Fragments; D009320:Atrial Natriuretic Factor