title: Significance of atrial natriuretic factor in chronic heart failure.
abstract: Since the discovery by de Bold et al in 1981 of the natriuretic and diuretic properties of atrial extract a vast literature on the physiological, pharmacological and pathological aspects of atrial peptides has accumulated. In this article we review the significance of atrial natriuretic factor, endogenous and exogenously administered, in chronic heart failure.
authors.affiliation: Department of Clinical Pharmacology, Ninewells Hospital, Dundee.
authors.forename: J
authors.initials: J
authors.lastname: McMurray
authors.forename: A D
authors.initials: AD
authors.lastname: Struthers
mesh_terms: D009320:Atrial Natriuretic Factor / Q000494:pharmacology / Q000627:therapeutic use*; D004231:Diuresis / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D009318:Natriuresis / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects
chemical_list: D009320:Atrial Natriuretic Factor