Studies of peripheral blood T lymphocytes in assessment of disease activity in rheumatic fever.
The study included three groups of children: (a) 38 with active rheumatic fever (ARF) and active carditis; 21 seen during their first attack and 17 during recurrence of activity, (b) 47 with inactive rheumatic fever (IARF); the period since activity was less than 3 years in 31 cases and more than 3 years in 16 cases. Using monoclonal antibodies and T lymphocyte blast transformation induced by PHA, we found: (1) low total T lymphocytes, helper-inducer cells and helper-inducer/suppressor-cytotoxic ratio which persisted for years; and (2) reduced lymphoblast transformation in active disease.
Hafez
M
M
Department of Paediatrics, Faculty of Medicine, Mansoura University, Egypt.
el-Shannawy
F
F
el-Salab
S
S
el-Morsi
Z
Z
el-Ziny
M
M
Al-Tonbary
Y
Y
Abdalla
A
A
Abou-el-Enein
A
A
D000293:Adolescent; D000911:Antibodies, Monoclonal; D002648:Child; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D009205:Myocarditis / Q000276:immunology; D012008:Recurrence; D012213:Rheumatic Fever / Q000276:immunology*; D012214:Rheumatic Heart Disease / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal