Uptake of technetium-99m methylene diphosphonate by fractured and osteoporotic bone after a pulse dose of vitamin D3.
The effect of a pulse dose of Vitamin D3 on uptake of [99mTc]MDP by fractured and osteoporotic bone, respectively, was compared with D3's effect on uptake by normal bone in rats. At 4, 7, and 14 days, respectively, after femoral fracture, basal uptake was significantly (p less than 0.005) increased at the fracture site by 336.8, 276.1, and 183.5%, respectively, over the contralateral control site. D3-treated rats had lower uptakes than untreated controls at all three fracture sites and at 12 of 15 normal bone sites but analysis of variance showed the uptake differences were not significant. Cortisone-induced osteoporosis caused a significant (p less than 0.05) decrease in basal uptake. The decrease occurred in all nine bone areas studied. D3 caused a significant (p less than 0.05) increase (mean 16.2%) in uptake by these osteoporotic bones, but a significant (0.1 greater than p greater than 0.05) decrease (mean 13.0%) in uptake by the same bones in normal controls. Thus, D3 had an effect on uptake by the bone lesion, osteoporosis, that differed from D3's effect on uptake by fracture or normal bone.
Carr
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EA
Carroll
M
M
Montes
M
M
Zielezny
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M
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002762:Cholecalciferol / Q000494:pharmacology*; D003348:Cortisone / Q000031:analogs & derivatives / Q000633:toxicity; D004164:Diphosphonates / Q000378:metabolism*; D005260:Female; D005264:Femoral Fractures / Q000378:metabolism*; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010024:Osteoporosis / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium / Q000378:metabolism*; D013669:Technetium Tc 99m Medronate; D013997:Time Factors
D004164:Diphosphonates; D002762:Cholecalciferol; D013667:Technetium; D003348:Cortisone; D013669:Technetium Tc 99m Medronate