Distribution of the flux control in convergent metabolic pathways: theory and application to experimental and simulated systems.
1. Metabolic systems involving branched convergent pathways are analyzed under Flux Control Theory, obtaining a relationship between the contribution of every convergent pathway to the total flux and its Flux Control Coefficient. 2. An experimental model system is carried out to demonstrate the physical application of some conclusions of theoretical treatment. 3. Two different types of branched pathways are simulated by computer. 4. In both cases results are in agreement with the theoretical conclusions, showing in addition some new aspects on metabolic control.
Torres
N V
NV
Departamento de Bioquimica y Biología Molecular, Facultad de Biología, Universidad de La Laguna, Canary Islands, Spain.
Mateo
F
F
Sicilia
J
J
Meléndez-Hevia
E
E
D003201:Computers; D004798:Enzymes / Q000378:metabolism*; D005941:Glucokinase / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D019298:Glucose-6-Phosphate; D005956:Glucose-6-Phosphate Isomerase / Q000378:metabolism; D005958:Glucosephosphates / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism*; D006593:Hexokinase / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological; D010732:Phosphofructokinase-1 / Q000378:metabolism; D010733:Phosphoglucomutase / Q000378:metabolism; D010762:Phosphorylase a / Q000378:metabolism
D004798:Enzymes; D005958:Glucosephosphates; D019298:Glucose-6-Phosphate; D006003:Glycogen; D010762:Phosphorylase a; D006593:Hexokinase; D010732:Phosphofructokinase-1; D005941:Glucokinase; D005956:Glucose-6-Phosphate Isomerase; D010733:Phosphoglucomutase; D005947:Glucose