title: Ipsilateral blepharospasm and contralateral hemidystonia and parkinsonism in a patient with a unilateral rostral brainstem-thalamic lesion: structural and functional abnormalities studied with CT, MRI, and PET scanning.
abstract: A patient developed progressive right hemidystonia in childhood. Subsequently, left-sided blepharospasm, slurred and stuttering speech, and right-sided rigidity and bradykinesia, responsive to dopamine agonists, appeared. Investigation with computed tomography and magnetic resonance imaging (MRI) at age 43 years revealed a left-sided calcified rostral brainstem-thalamic lesion of uncertain aetiology. Although no structural lesion was seen in the striatal regions, L-[18F]-fluorodopa uptake was severely diminished in the left striatum but normal on the right. Dopamine receptor binding identified by [11C]-methylspiperone was in the normal range on both sides.
authors.affiliation: MRC Cyclotron Unit, Hammersmith Hospital, London, England.
authors.forename: K L
authors.initials: KL
authors.lastname: Leenders
authors.forename: R S
authors.initials: RS
authors.lastname: Frackowiak
authors.forename: N
authors.initials: N
authors.lastname: Quinn
authors.forename: D
authors.initials: D
authors.lastname: Brooks
authors.forename: D
authors.initials: D
authors.lastname: Sumner
authors.forename: C D
authors.initials: CD
authors.lastname: Marsden
mesh_terms: D000328:Adult; D001764:Blepharospasm / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology*; D003342:Corpus Striatum / Q000378:metabolism; D004421:Dystonia / Q000473:pathology*; D005141:Eyelid Diseases / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010300:Parkinson Disease / Q000473:pathology*; D011954:Receptors, Dopamine / Q000378:metabolism; D017448:Receptors, Dopamine D2; D013788:Thalamus / Q000473:pathology*; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2