Expression of c-myc proto-oncogene in hearts and cultured smooth muscle cells of spontaneously hypertensive rats.
We studied the expression of c-myc proto-oncogene in hearts and cultured aortic smooth muscle cells of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY), in order to investigate the association of the c-myc gene with cardiac hypertrophy and atherosclerosis in SHR. Transcription of the c-myc gene in hearts of SHR was higher than that of WKY at 10 weeks of age, when cardiac hypertrophy had developed in SHR. The c-myc gene expression in cultured aortic smooth muscle cells of SHR, after the addition of serum to the serum-deprived cultures, was higher than that of WKY. These results suggest that the enhanced expression of the c-myc gene in the hearts and cultured aortic smooth muscle cells of SHR may be associated with the growth control of these cells, and may play a role in the development of cardiac hypertrophy and atherosclerotic lesions in SHR.
Negoro
N
N
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Inariba
H
H
Inoue
T
T
Kanayama
Y
Y
Takeda
T
T
D000818:Animals; D006332:Cardiomegaly / Q000378:metabolism*; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D006321:Heart / Q000502:physiology*; D009130:Muscle, Smooth / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*
D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc