title: Influence of several perturbants on the rate of autoxidation of horse heart ferrocytochrome c.
abstract: The effect of several different types of perturbants and pH on the rate of autoxidation of horse heart ferrocytochrome c was investigated. The kinetic behavior is unique to each perturbant used. Rates of autoxidation followed first-order kinetics over the time span (0-180 min) studied. The Cl- and Br- anions exhibit an initial increase in the rate of autoxidation up to 100 mM, followed by a decrease in kinetics at 500 mM anion concentration. The ClO4- anion exhibits only an increase in the rate of autoxidation with increasing ionic strength, where as, propylurea, a hydrophobic perturbant, is not effective in altering the rate of autoxidation at equivalent concentrations. These studies suggest that the perturbations of the reduced form of cytochrome c in solution involve mainly non-specific solvent effects.
authors.forename: J P
authors.initials: JP
authors.lastname: Harrington
authors.forename: T L
authors.initials: TL
authors.lastname: Carrier
mesh_terms: D000818:Animals; D002712:Chlorides / Q000494:pharmacology; D003574:Cytochrome c Group; D005290:Ferric Compounds; D005296:Ferrous Compounds; D006736:Horses; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010084:Oxidation-Reduction; D010472:Perchlorates / Q000494:pharmacology; D017670:Sodium Compounds; D013816:Thermodynamics
chemical_list: D002712:Chlorides; D003574:Cytochrome c Group; D005290:Ferric Compounds; D005296:Ferrous Compounds; D010472:Perchlorates; D017670:Sodium Compounds; C031068:sodium perchlorate