[Secretion of gastric acid, gastrin and cyclic nucleotides in relation to the action of the vagus nerve].
Changes on levels gastric acidity, on serum gastrin, cAMP and cGMP levels were studied in 18 healthy volunteers after either stimulation (injection of 0.2 IU of soluble insulin/kg body weight to a group of 9 subjects) or stimulation and inhibition (injection of insulin plus atropine per os to the other group of 9 subjects) of the vagus nerve. After vagus nerve stimulation, gastric acid levels, serum gastrin and cGMP were raised and cAMP reduced. After stimulation and inhibition of vagus nerve, gastrin and cAMP were increased, cGMP reduced and gastric acid levels remained unchanged. These findings suggest that the vagus nerve, and more particularly the acetylcholine released from its metaganglionic fibers, stimulate parietal cells provoking acid secretion, and also stimulate G cells with subsequent gastrin secretion through cGMP.
Karydakis
P
P
Safioleas
M
M
Papastratis
G
G
Chalkiadakis
G E
GE
Simopoulos
C
C
Livanou
T
T
Miras
C
C
D000109:Acetylcholine / Q000502:physiology; D000328:Adult; D001285:Atropine / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis; D000242:Cyclic AMP / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000166:cytology; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D008297:Male; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D010295:Parietal Cells, Gastric / Q000378:metabolism; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology*
D001786:Blood Glucose; D005755:Gastrins; D007328:Insulin; D009712:Nucleotides, Cyclic; D001285:Atropine; D000242:Cyclic AMP; D006152:Cyclic GMP; D000109:Acetylcholine
La sécrétion de l'acide gastrique, de la gastrine et des nucléotides cycliques en rapport avec l'action du nerf vague.