title: Genetic restrictions and cellular interactions in the induction of anterior chamber associated immune deviation (ACAID).
abstract: The injection of antigen into the anterior chamber (AC) of the eye results in a pattern of systemic immune responses termed anterior chamber associated immune deviation (ACAID). ACAID is characterized by down-regulation of delayed-type hypersensitivity (DTH) by T suppressor cells with normal antibody production and cytotoxic T cell responses. To better understand the mechanisms of ACAID, we studied the genetic restrictions and intraocular T cell interactions in TNP-ACAID. We report that (a) antigen is not reprocessed by the eye for the induction of suppression in TNP-ACAID, (b) the T cells injected into the AC and the recipient animal must match at genes in the immunoglobulin heavy chain (IgH) region of chromosome XII for TNP-ACAID to be induced, (c) TNP-coupled Lyt-1+, I-J+ T cells present antigen to viable T cells within the eye to induce systemic suppression, (d) although there is an IgH restriction between the T cells injected into the AC and the recipient, the interaction between the T cell antigen-presenting cell and the Tsi-cells in the AC inoculum is restricted to the I-J portion of the major histocompatibility complex, and (e) the two Tsi-cells that initiate the suppressor cascade have different antigen presentation requirements. These results further emphasize the complex interaction between T cells, which serves to control immune reactions in the eye.
authors.affiliation: Department of Ophthalmology, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: T A
authors.initials: TA
authors.lastname: Ferguson
authors.forename: H J
authors.initials: HJ
authors.lastname: Kaplan
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000276:immunology*; D000938:Antigen-Presenting Cells / Q000276:immunology; D005803:Genes, Immunoglobulin / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000235:genetics / Q000276:immunology*; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology; D007111:Immunity, Cellular / Q000235:genetics / Q000276:immunology; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014302:Trinitrobenzenesulfonic Acid / Q000276:immunology
chemical_list: D007143:Immunoglobulin Heavy Chains; D014302:Trinitrobenzenesulfonic Acid