Behavioral pharmacokinetics of marijuana.
Male volunteer subjects smoked one marijuana cigarette containing 100, 200, or 250 micrograms/kg delta-9-tetrahydrocannabinol (THC) and were tested on three perceptual-motor performance measures related to driving. Performance was measured and blood samples were collected for 24 h after smoking. The covariation between pharmacodynamics of performance and pharmacokinetics of THC in plasma was investigated for decrement in performance as the response to smoking a single marijuana cigarette. A significant linear correlation was found between tracking errors under divided attention and THC plasma levels over 5-25 ng/ml for approximately 2 h after smoking. A sigmoid relation was found between critical tracking breakpoint and log THC plasma levels over 2-25 ng/ml for approximately 7 h after smoking.
Barnett
G
G
Licko
V
V
Thompson
T
T
D000328:Adult; D001288:Attention / Q000187:drug effects; D001334:Automobile Driving; D002188:Cannabis; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000097:blood / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D013759:Dronabinol