Mesocortical dopaminergic function and human cognition.
In summary, we have reviewed rCBF data in humans that suggest that mesoprefrontal dopaminergic activity is involved in human cognition. In patients with Parkinson's disease and possibly in patients with schizophrenia, prefrontal physiological activation during a cognitive task that appears to depend on prefrontal neural systems correlates positively with cognitive performance on the task and with clinical signs of dopaminergic function. It may be possible in the future to examine prefrontal dopamine metabolism directly during prefrontal cognition using positron emission tomography and tracers such as F-18 DOPA.
Weinberger
D R
DR
Clinical Brain Disorders Branch, Saint Elizabeths Hospital, Washington, DC 20032.
Berman
K F
KF
Chase
T N
TN
D002540:Cerebral Cortex / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D003071:Cognition / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology; D008636:Mesencephalon / Q000503:physiopathology*; D010300:Parkinson Disease / Q000503:physiopathology; D012559:Schizophrenia / Q000503:physiopathology; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D004298:Dopamine