title: Relationship between changes in plasma lipoprotein concentrations and fecal steroid excretion in man during consumption of four experimental diets.
abstract: Limited information is available on the mechanism by which changes in nutrient intake influence plasma lipids. We compared the effects on plasma lipoprotein levels of 3 dietary modifications involving changes in total fat intake (27-40% of calories), cholesterol intake (100-250 mg/1000 kcal), the dietary polyunsaturated to saturated fatty acid ratio (0.3-1.0) and intake of vegetable-derived fiber and protein. On these 3 diets, plasma low density lipoprotein was reduced by 26-34%. Fecal bile acid excretion was similar on all diets (363-379 mg/day). There was no alteration in fecal bile acid output associated with an increase in polyunsaturated or total fat intake. Sterol balance became significantly more negative during consumption of only 1 of the 3 cholesterol-lowering diets. The observed reduction in plasma cholesterol levels was not associated with an increase in fecal bile acid output suggesting that diet-induced changes in circulating cholesterol are not maintained by an increase in sterol turnover but may reflect alterations in hepatic cholesterol and lipoprotein synthesis.
authors.forename: R M
authors.initials: RM
authors.lastname: Kay
authors.forename: M
authors.initials: M
authors.lastname: Jacobs
authors.forename: M B
authors.initials: MB
authors.lastname: Katan
authors.forename: N E
authors.initials: NE
authors.lastname: Miller
authors.forename: B
authors.initials: B
authors.lastname: Lewis
mesh_terms: D000328:Adult; D001647:Bile Acids and Salts / Q000032:analysis; D002784:Cholesterol / Q000032:analysis; D004041:Dietary Fats / Q000008:administration & dosage*; D004043:Dietary Fiber / Q000008:administration & dosage*; D005243:Feces / Q000032:analysis*; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013256:Steroids / Q000032:analysis*
chemical_list: D001647:Bile Acids and Salts; D004041:Dietary Fats; D004043:Dietary Fiber; D008074:Lipoproteins; D013256:Steroids; D002784:Cholesterol