The effect of cyclosporin A on Trypanosoma musculi infection of mice.
Cyclosporin A treatment of mice infected with Trypanosoma musculi mimicked the effect of T-cell deprivation in increasing the parasitemia and lowering the antibody responses. However, in contrast to T-cell deprivation, cyclosporin A treated mice were still able to clear the parasites from the blood. As expected, T-cell deprived mice were not responsive to cyclosporin A. It is suggested that antibodies against T-independent antigens of the parasite are ineffective in promoting elimination of the trypanosomes. These findings support the importance of T-helper cells in the final elimination of T. musculi from the blood of mice.
Roger
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M
Département de Microbiologie et Immunologie, Université de Montréal, Qué, Canada.
Vigeant
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P
Viens
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D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D003524:Cyclosporins / Q000494:pharmacology*; D007165:Immunosuppression Therapy; D051379:Mice; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology; D014345:Trypanosoma / Q000276:immunology; D014352:Trypanosomiasis / Q000276:immunology*
D000913:Antibodies, Protozoan; D003524:Cyclosporins