title: Changes in factor VIII proteins after cardiopulmonary bypass in man suggest endothelial damage.
abstract: 16 patients undergoing coronary artery bypass grafting using cardiopulmonary bypass (CPB) had blood samples taken at various times before, during and up to 1 week after surgery for estimation of beta-thromboglobulin (BTG), alpha-1-antichymotrypsin (ACT), factor VIII procoagulant protein (VIII:C), von Willebrand factor antigen (vWF:Ag) and ristocetin co-factor (vWF:RiCoF). vWF:Ag and vWF:RiCoF rose during and following surgery in a different manner to ACT. At 1 week there was a significantly disproportionate rise in vWF:Ag compared to vWF:RiCoF which suggested a degree of pulmonary endothelial damage. Prostacyclin, which was administered to 8 of the patients during CPB, reduced platelet activation as measured by a reduction in the release of BTG and also attenuated the consumption of VIII:C. It had no effect on pulmonary endothelial damage as measured by the ratio of vWF:Ag to vWF:RiCoF.
authors.affiliation: Department of Respiratory Physiology, Papworth Hospital, Cambridge, England.
authors.forename: D K
authors.initials: DK
authors.lastname: Jones
authors.forename: R
authors.initials: R
authors.lastname: Luddington
authors.forename: T W
authors.initials: TW
authors.lastname: Higenbottam
authors.forename: J
authors.initials: J
authors.lastname: Scott
authors.forename: N
authors.initials: N
authors.lastname: Cavarocchi
authors.forename: D
authors.initials: D
authors.lastname: Reardon
authors.forename: J
authors.initials: J
authors.lastname: Calvin
authors.forename: J
authors.initials: J
authors.lastname: Wallwork
mesh_terms: D000328:Adult; D000368:Aged; D000941:Antigens / Q000378:metabolism; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D004730:Endothelium, Vascular / Q000378:metabolism*; D011464:Epoprostenol / Q000494:pharmacology; D005169:Factor VIII / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D000514:alpha 1-Antichymotrypsin / Q000378:metabolism; D001620:beta-Thromboglobulin / Q000378:metabolism; D014841:von Willebrand Factor / Q000276:immunology
chemical_list: D000941:Antigens; C029417:Von Willebrand antigen; D000514:alpha 1-Antichymotrypsin; D001620:beta-Thromboglobulin; D014841:von Willebrand Factor; D005169:Factor VIII; D011464:Epoprostenol