title: Residual plasma concentrations of acitretin (Ro 10-1670) and its metabolite (Ro 13-7652) after chronic administration.
abstract: In order to study the elimination of Ro 10-1670 (acitretin) and Ro 13-7652, its 13-cis-isomeric metabolite after chronic administration, determination of the residual plasma concentrations of these two compounds were assayed in 9 patients in a range of 22-30 days following cessation of a 2- to 7.5-month course with daily oral doses of 10-50 mg of acitretin. A highly sensitive HPLC method was used (2 ng/ml). Residual plasma concentrations of Ro 10-1670 were below the quantification limit in all cases. Residual plasma concentrations of Ro 13-7652 were below the quantification limit in 7 cases and respectively of 3 and 4 ng/ml in the other 2 cases. These data appear to confirm the absence of storage of acitretin even after an extended course of therapy.
authors.affiliation: Clinique Dermatologique, Hotel-Dieu, Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Berbis
authors.forename: H
authors.initials: H
authors.lastname: Bun
authors.forename: N R
authors.initials: NR
authors.lastname: Al Mallah
authors.forename: A
authors.initials: A
authors.lastname: Durand
authors.forename: C
authors.initials: C
authors.lastname: Rognin
authors.forename: J M
authors.initials: JM
authors.lastname: Geiger
authors.forename: Y
authors.initials: Y
authors.lastname: Privat
mesh_terms: D017255:Acitretin; D000293:Adolescent; D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy / Q000378:metabolism; D014212:Tretinoin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D014212:Tretinoin; D017255:Acitretin