title: Fatal gastroenteritis associated with coronaviruslike particles.
abstract: The role of human enteric coronaviruses in infantile gastroenteritis is controversial. We detected coronaviruslike particles in the intestinal contents and within the epithelial cells of the ileum in a 15-month-old infant who had postmortem evidence of severe enteritis. Ultrastructural findings consistent with in vivo coronavirus replication in the human small intestine support a causative role for this agent in gastroenteritis.
authors.forename: P J
authors.initials: PJ
authors.lastname: Rettig
authors.forename: G P
authors.initials: GP
authors.lastname: Altshuler
mesh_terms: D001344:Autopsy; D003332:Coronaviridae / Q000302:isolation & purification* / Q000648:ultrastructure; D003333:Coronaviridae Infections / Q000382:microbiology* / Q000473:pathology; D004848:Epithelium / Q000382:microbiology / Q000648:ultrastructure; D005243:Feces / Q000382:microbiology; D005759:Gastroenteritis / Q000209:etiology / Q000382:microbiology* / Q000473:pathology; D005766:Gastrointestinal Contents; D006801:Humans; D007223:Infant; D007421:Intestine, Small / Q000382:microbiology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D014771:Virion / Q000648:ultrastructure