Histological phases of Bactrim-induced fixed drug eruption. The report of one case.
A case is described of a patient with Bactrim-induced fixed drug eruption (FDE). Histological studies were performed at 1 day and 5 days after the drug exposure. While the 5-day-old lesion showed changes classically recognized as FDE, the 1-day-old lesion showed changes typical of a hypersensitivity response: diffuse spongiosis, dermal edema and hemorrhage, neutrophilic polymorphonuclear leukocyte abscess formations, and large numbers of eosinophils. This report underscores the dynamic cellular changes that occur in the evolving FDE lesion.
Van Voorhees
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A
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06510-8059.
Stenn
K S
KS
D000368:Aged; D000667:Ampicillin / Q000627:therapeutic use; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects*; D001706:Biopsy; D004338:Drug Combinations / Q000009:adverse effects; D003875:Drug Eruptions / Q000473:pathology*; D006801:Humans; D008297:Male; D011776:Pyuria / Q000188:drug therapy; D013420:Sulfamethoxazole / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000892:Anti-Infective Agents, Urinary; D004338:Drug Combinations; D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole