title: Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone.
abstract: Evidence from three types of experiments indicates that platelet activating factor (PAF)1 is an important mediator of endotoxin-induced hypotension in rats. a) Endotoxin infusion stimulates the time-dependent appearance of PAF in the blood. b) PAF infusion results immediately (less than 30 sec) in hypotension while endotoxin-induced hypotension takes 3-5 min to occur, allowing time for PAF production. c) Infusion of the specific PAF-receptor antagonist kadsurenone (2.2 mumole/kg bolus, 0.9 mumoles/min/kg continuous infusion), which inhibits PAF-induced hypotension by 67%, causes a 67% reversal of endotoxin-elicited hypotension. An additional finding of this study is that rats respond hypotensively to each of a series of low-dose PAF infusions but only to the first low-dose endotoxin infusion. These endotoxin-refractory rats do respond to subsequent PAF infusions.
authors.forename: T W
authors.initials: TW
authors.lastname: Doebber
authors.forename: M S
authors.initials: MS
authors.lastname: Wu
authors.forename: J C
authors.initials: JC
authors.lastname: Robbins
authors.forename: B M
authors.initials: BM
authors.lastname: Choy
authors.forename: M N
authors.initials: MN
authors.lastname: Chang
authors.forename: T Y
authors.initials: TY
authors.lastname: Shen
mesh_terms: D000818:Animals; D001572:Benzofurans; D001578:Benzopyrans / Q000494:pharmacology*; D004731:Endotoxins; D004926:Escherichia coli; D005260:Female; D007022:Hypotension / Q000139:chemically induced*; D007700:Kinetics; D017705:Lignans; D010972:Platelet Activating Factor / Q000502:physiology*; D010980:Platelet Membrane Glycoproteins; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology; D043562:Receptors, G-Protein-Coupled
chemical_list: D001572:Benzofurans; D001578:Benzopyrans; D004731:Endotoxins; D017705:Lignans; D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor; C044540:kadsurenone