[In vitro activity of seven gyrase inhibitors of a group of heterocyclic carbonic acids against nonfermenting gram negative rods (nonfermenters)].
MIC (minimal inhibitory concentration) determinations for nalidixic acid, cinoxacin, pipemidic acid, norfloxacin, enoxacin, and ciprofloxacin were done by agar dilution on isosensitest agar (oxoid). Bacterial strains investigated were 189 Pseudomonas aeruginosa, 164 Acinetobacter lwoffii, 4 Ps. maltophilia, 3 Ps. putrefaciens and 3 Ps. odorans. The results in summary are: Ciprofloxacin is the most active gyrase inhibitor against Ps. aeruginosa as well as against other nonfermentative gram-negative rods, versus Ps. aeruginosa norfloxacin is a little more active than ofloxacin, against nonfermentative gram-negative rods other than Ps. aeruginosa norfloxacin is markedly less active than ofloxacin. Problems concerning cross-resistance of new gyrase inhibitors are discussed.
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D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002937:Cinoxacin / Q000494:pharmacology; D002939:Ciprofloxacin; D004352:Drug Resistance, Microbial; D015365:Enoxacin; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D009287:Naphthyridines / Q000494:pharmacology; D009643:Norfloxacin; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology; D010876:Pipemidic Acid / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology; D059005:Topoisomerase II Inhibitors
D000900:Anti-Bacterial Agents; D009287:Naphthyridines; D010078:Oxazines; D011804:Quinolines; D059005:Topoisomerase II Inhibitors; D015365:Enoxacin; D009268:Nalidixic Acid; D002939:Ciprofloxacin; D015242:Ofloxacin; D002937:Cinoxacin; D010876:Pipemidic Acid; D009643:Norfloxacin
In-vitro-Aktivität von sieben Gyrase-Hemmern aus der Gruppe heterozyklischer Carbonsäuren gegen nichtfermentative gramnegative Stäbchen (Nonfermenter).