[Paradoxical hyperglucagonemia after oral administration of glucose in diabetic dogs. Impact of the cholinergic nervous system].
Alloxan diabetic dogs with insulin deficiency showed a transient but significant rise in glucagon levels after oral glucose load (1 g/kg). Pretreatment with atropine sulfate (0.2 mg/kg intravenously) totally suppressed this increase. So, the transient paradoxical rise of glucagon level observed in diabetic dogs after glucose intake is under cholinergic control.
Hillaire-Buys
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D
Faculté de Médecine, UA 599 du CNRS, Montpellier.
Ribes
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G
Gross
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Loubatières-Mariani
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MM
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002799:Cholinergic Fibers / Q000502:physiology*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004285:Dogs; D005934:Glucagon / Q000097:blood*; D005947:Glucose / Q000008:administration & dosage*; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D005947:Glucose
Hyperglucagonémie paradoxale après administration orale de glucose chez le chien diabétique. Implication du système nerveux cholinergique.