title: Conditioned taste aversion suppresses induction of delayed-type hypersensitivity immune reactions.
abstract: Conditioned taste aversion was induced in mice by pairing saccharin drinking with an intraperitoneal injection of lithium chloride, a toxic but nonimmunosuppressive drug. Conditioned mice showed not only suppressed saccharin drinking but also a 75% reduction in the induction of delayed-type hypersensitivity immune responses to low doses of sheep erythrocytes. This effect was observed with doses of lithium chloride which had no effect of their own on immune functions. In addition, a reduction in water consumption was not responsible for the reduced immune response of conditioned mice since the immune responses of water deprived mice did not differ from those of nondeprived mice. Conditioned mice exposed to saccharin had higher plasma levels of glucocorticoids than nonconditioned mice, suggesting that the experience of being reexposed to a taste paired with lithium chloride was perceived as aversive. These data demonstrate that alterations in immune functions can be induced by a conditioned taste aversion procedure independently of any immunosuppressive drug.
authors.forename: K W
authors.initials: KW
authors.lastname: Kelley
authors.forename: R
authors.initials: R
authors.lastname: Dantzer
authors.forename: P
authors.initials: P
authors.lastname: Mormede
authors.forename: H
authors.initials: H
authors.lastname: Salmon
authors.forename: J M
authors.initials: JM
authors.lastname: Aynaud
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D002712:Chlorides / Q000506:poisoning; D003214:Conditioning, Classical / Q000502:physiology*; D004326:Drinking / Q000187:drug effects; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007111:Immunity, Cellular / Q000187:drug effects; D008094:Lithium / Q000506:poisoning; D018021:Lithium Chloride; D051379:Mice; D008807:Mice, Inbred BALB C; D013649:Taste / Q000502:physiology*
chemical_list: D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride