The antigen-major histocompatibility complex-T cell receptor interaction. A structural analysis.
In summary, we wish to propose that regions on MHC molecules interact with complementary regions on processed peptide antigens, and that the resultant Ag-MHC complex forms a conformation with separate functional regions that are able to interact with similarly complementary areas on T cell receptors. It is the product of these interactions that determines whether a given peptide Ag is capable of binding the MHC molecule, and whether a given Ag-MHC complex is capable of stimulating a particular T cell. As more becomes known about the molecular aspects of MHC-restricted, Ag-specific T cell activation, it will become clear which amino acid residues on the Ag, MHC, and TCR are involved in these interactions.
Williams
W V
WV
Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia.
Weiner
D B
DB
Wadsworth
S
S
Greene
M I
MI
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D006649:Histocompatibility Antigens; D006801:Humans; D008285:Major Histocompatibility Complex; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D011948:Receptors, Antigen, T-Cell; D013601:T-Lymphocytes / Q000276:immunology
D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D006649:Histocompatibility Antigens; D011948:Receptors, Antigen, T-Cell