A note on the mechanism of resistance to anoxia and ischaemia in pathophysiological mammalian myelinated nerve.
Computer simulation of the action potential in myelinated nerve fibres show that the metabolic cost of conduction of an impulse is less than normal in a slightly depolarised fibre. This would account, at least in part, for the greater resistance to ischaemia and anoxia of nerves from diabetics and other pathophysiological conditions.
Ritchie
J M
JM
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000503:physiopathology; D004573:Electrolytes / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D007511:Ischemia / Q000503:physiopathology*; D009413:Nerve Fibers, Myelinated / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000098:blood supply / Q000503:physiopathology; D009435:Synaptic Transmission
D004573:Electrolytes; D000251:Adenosine Triphosphatases