The vasodilator effect of human atrial natriuretic factor (99-126) on human omental arteries.
The effect of synthetic human atrial natriuretic factor [ANF-(99-126)] on human omental arteries was investigated. The compound produced concentration-dependent relaxation, 10, 50 and 90% of maximum effect being observed at about 1, 10 and 100 nmol/l, respectively. These concentrations are considerably higher than those measured by radio-immunoassay in human plasma, even under extreme conditions (0.001-0.3 nmol/l). Therefore, ANF can dilate human resistance-size arteries, but whether it does so under physiological conditions has not been established.
Bruschi
G
G
Istituto di Clinica Medica e Nefrologia, Università di Parma, Italy.
Bruschi
M E
ME
Orlandini
G
G
Banchini
E
E
Borghetti
A
A
D000328:Adult; D000818:Animals; D001158:Arteries / Q000187:drug effects*; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D051381:Rats; D014664:Vasodilation / Q000187:drug effects*
C472955:NPPA protein, human; D009320:Atrial Natriuretic Factor