Lymph node pathology of HTLV and HTLV-associated neoplasms.
Human T-cell leukemia/lymphoma virus I can transform mature T-lymphocytes in vitro and is associated with the human T-cell cancer, adult T-cell leukemia/lymphoma. Adult T-cell leukemia/lymphoma is a distinct clinicopathological entity associated with leukemia, lymphadenopathy, hepatosplenomegaly, skin lesions, hypercalcemia, and lytic bone lesions. Although morphologically diverse it pursues an aggressive clinical course. Human T-cell leukemia/lymphoma virus III is associated with acquired immunodeficiency syndrome, which in its early stages shows follicular lymphoid hyperplasia; however, lymphoid atrophy is progressive and ultimately results in virtually total lymphoid depletion of lymph nodes. Patients with human T-cell leukemia/lymphoma virus III infections appear to have an increased risk of high-grade B-cell lymphomas and perhaps Hodgkin's disease.
Jaffe
E S
ES
Clark
J
J
Steis
R
R
Blattner
W
W
Macher
A M
AM
Longo
D L
DL
Reichert
C M
CM
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology*; D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D017977:Deltaretrovirus; D006689:Hodgkin Disease / Q000150:complications; D006716:Homosexuality; D006801:Humans; D007239:Infections / Q000209:etiology; D007938:Leukemia / Q000150:complications / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008223:Lymphoma / Q000150:complications / Q000473:pathology*; D008297:Male; D011379:Prognosis; D012192:Retroviridae Infections / Q000473:pathology*; D012514:Sarcoma, Kaposi / Q000150:complications / Q000473:pathology; D012867:Skin / Q000473:pathology; D013601:T-Lymphocytes