Therapeutic ratio of photodynamic therapy in the treatment of superficial tumours of skin and subcutaneous tissues in man.
Six patients with a total of 34 assessible subcutaneous or cutaneous lesions were treated with photodynamic therapy using 1.0, 1.5 or 2.0 mg kg-1 of photofrin II and 25-100 J cm-2 of red light (630 nm). The incidence of complete tumour response and skin necrosis were used to try to assess the therapeutic ratio of photodynamic therapy. The tumour response rate was 47%. The rate of tumour control and necrosis increased in parallel with dose of photosensitizer and light used, implying a low therapeutic ratio. However, the use of necrosis with eschar formation as an end-point for severe normal tissue damage is questioned as the skin healed completely in all cases and with minimal discomfort to the patients.
Gilson
D
D
Department of Radiotherapy, University of Leeds, Cookridge Hospital, Leeds, UK.
Ash
D
D
Driver
I
I
Feather
J W
JW
Brown
S
S
D017323:Dihematoporphyrin Ether; D004305:Dose-Response Relationship, Drug; D006414:Hematoporphyrin Photoradiation / Q000009:adverse effects; D006415:Hematoporphyrins / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D009336:Necrosis; D010778:Photochemotherapy; D012867:Skin / Q000187:drug effects / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy*
D006415:Hematoporphyrins; D017323:Dihematoporphyrin Ether