title: Dehydroepiandrosterone sulphate and dehydroepiandrosterone in serum: differences related to age and sex.
abstract: Serum concentrations of dehydroepiandrosterone sulphate (DHAS) were determined in 590 healthy women aged 20-87 yr. Simultaneous assays of dehydroepiandrosterone (DHA) were performed in 417 of the women. DHA and DHAS levels correlated negatively with age while the DHA/DHAS ratio proved to be unrelated to age. When values for 60 healthy men in the age range 20-84 yr were compared with those obtained in 60 randomly-selected healthy women who were exactly age-matched, the DHAS levels were found to be significantly lower and the DHA/DHAS ratios significantly higher in the women. These results might be of use in establishing normal clinical ranges for serum DHA, DHAS and the DHA/DHAS ratio in women.
authors.affiliation: Department of Obstetrics and Gynaecology, Karolinska Institutet, Huddinge University Hospital, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Carlström
authors.forename: S
authors.initials: S
authors.lastname: Brody
authors.forename: N O
authors.initials: NO
authors.lastname: Lunell
authors.forename: A
authors.initials: A
authors.lastname: Lagrelius
authors.forename: G
authors.initials: G
authors.lastname: Möllerström
authors.forename: A
authors.initials: A
authors.lastname: Pousette
authors.forename: G
authors.initials: G
authors.lastname: Rannevik
authors.forename: R
authors.initials: R
authors.lastname: Stege
authors.forename: B
authors.initials: B
authors.lastname: von Schoultz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood*; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D006801:Humans; D008297:Male; D008593:Menopause / Q000097:blood; D008598:Menstruation; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors
chemical_list: D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate