A route to the total synthesis of iso-LTB4 system.
The convergent synthesis of the iso-Leukotriene B4 (XVI) (as diastereoisomeric mixture with the desired geometry), by Wittig's condensation of the two precursor synthons at 6 (VI) and 14 C (XIV), starting from the common cyclic acrylaldehyde dimer (I), is reported.
Pirillo
D
D
Gazzaniga
A
A
Leggeri
P
P
Giaccone
P
P
Traverso
G
G
D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D007975:Leukotriene B4 / Q000138:chemical synthesis*; D013237:Stereoisomerism
D007975:Leukotriene B4