title: Characterization of HCO3-/CO2 pool sizes and kinetics in infants.
abstract: The first bicarbonate pool sizes and kinetic data necessary for the interpretation of substrate oxidation studies have been determined in six fed, nonacidotic infants, ages 2.5 to 5 months. Following an intravenous bolus of NaH13CO3 (50 mumol/kg), breath samples were collected over 240 min for the analysis of breath 13CO2. Each breath 13CO2 disappearance curve was fitted to a multicompartmental bicarbonate model previously derived in adults. The mean sizes of the three bicarbonate pools were: 7.4 +/- 0.8 mmol/kg (central pool), 15.1 +/- 4.8 mmol/kg (rapidly exchanging peripheral pool), and 8.8 +/- 3.5 mmol/kg (slowly exchanging peripheral pool). The mean percentage dose recovery was 57 +/- 10%. The pool sizes suggested that extensive metabolic exchange of carbon between HCO3- and organic metabolites occurred in the infant.
authors.forename: C S
authors.initials: CS
authors.lastname: Irving
authors.forename: C H
authors.initials: CH
authors.lastname: Lifschitz
authors.forename: W W
authors.initials: WW
authors.lastname: Wong
authors.forename: T W
authors.initials: TW
authors.lastname: Boutton
authors.forename: B L
authors.initials: BL
authors.lastname: Nichols
authors.forename: P D
authors.initials: PD
authors.lastname: Klein
mesh_terms: D001639:Bicarbonates / Q000008:administration & dosage / Q000378:metabolism*; D001944:Breath Tests; D002245:Carbon Dioxide / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007700:Kinetics; D012964:Sodium / Q000008:administration & dosage / Q000378:metabolism; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D002245:Carbon Dioxide; D017693:Sodium Bicarbonate; D012964:Sodium