Atrial natriuretic peptide in human urine.
A highly sensitive radioimmunoassay to measure atrial natriuretic peptide (ANP) concentration in urine has been established, and its clinical usefulness is presented. ANP in urine was stable at 4 degrees C for several days and was easily measured by our radioimmunoassay. The average ANP excretion in 65 healthy persons was 25.0 +/- 1.4 ng/day (mean +/- SEM) and the fractional excretion of ANP was 0.7 +/- 0.05%. In 14 patients with congestive heart failure, the average ANP excretion was 119.2 +/- 29.4 ng/day, which decreased to 53.3 +/- 11.0 after successful treatment.
Ando
K
K
Kitasato Biochemical Laboratories, Bristol-Myers, Kanagawa, Japan.
Umetani
N
N
Kurosawa
T
T
Takeda
S
S
Katoh
Y
Y
Marumo
F
F
D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000652:urine*; D004071:Digitalis Glycosides / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D006333:Heart Failure / Q000188:drug therapy / Q000652:urine*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D004071:Digitalis Glycosides; D004232:Diuretics; D009320:Atrial Natriuretic Factor