Protective effect of 13-cis-retinoic acid on hematoporphyrin derivative-induced cell photosensitivity in vitro.
The influence of 13-cis-retinoic acid on the light-caused injury of hematoporphyrin-pretreated nontransformed 10 T1/2 fibroblasts and N2a neuroblastoma cells was investigated. Retinoid reduced the percentage of damaged cells as assessed by the plating efficiency assay. N2a neuroblastoma cells were found to be better protected than 10 T1/2 cells by 13-cis-retinoic acid on hematoporphyrin light-induced injury.
Szaniawska
B
B
Department of Tumor Biology, Cancer Center of the Maria Skłodowska-Curie Institute, Warsaw, Poland.
Janik
P
P
Ostrowski
J
J
Graczyk
A
A
D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D002460:Cell Line; D002478:Cells, Cultured; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000494:pharmacology*; D007536:Isomerism; D015474:Isotretinoin; D051379:Mice; D009447:Neuroblastoma; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D014212:Tretinoin / Q000494:pharmacology*
D006415:Hematoporphyrins; D011838:Radiation-Sensitizing Agents; D014212:Tretinoin; D017324:Hematoporphyrin Derivative; D015474:Isotretinoin