title: Comparison of the action of cholinomimetics and pentagastrin on gastric secretion in dogs.
abstract: Stimulation of acid secretion by muscarinic cholinomimetic agents depended on the periodic interdigestive activity of the stomach. This explains the peak and following fade. Pentagastrin stimulated gastric secretion after a fixed interval and did not depend on the interdigestive activity. Neither gastrin nor methacholine directly contracted the gallbladder in the doses used. A sustained secretion of gastric acid and pepsin, such as follows a meal, required both hormonal stimulation and gastric distension. The magnitude of the acid response from Heidenhain pouches following meals suggested that pentagastrin doses commonly used experimentally greatly exceed the physiological.
authors.forename: D F
authors.initials: DF
authors.lastname: Magee
authors.forename: S
authors.initials: S
authors.lastname: Naruse
authors.forename: A
authors.initials: A
authors.lastname: Pap
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology; D004285:Dogs; D005502:Food; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D008688:Methacholine Compounds / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology*; D010418:Pentagastrin / Q000494:pharmacology*; D010425:Pentolinium Tartrate / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism; D011189:Potassium Chloride / Q000494:pharmacology; D017693:Sodium Bicarbonate; D012965:Sodium Chloride / Q000494:pharmacology; D013997:Time Factors
chemical_list: D001639:Bicarbonates; D008688:Methacholine Compounds; D010277:Parasympathomimetics; D012965:Sodium Chloride; D011189:Potassium Chloride; D017693:Sodium Bicarbonate; D010425:Pentolinium Tartrate; D010434:Pepsin A; D010418:Pentagastrin