Clinical value of immunolymphscintigraphy in patients with breast cancer.
Thirty four patients suspected of suffering from breast cancer were investigated by immunolymphscintigraphy (ILS) a few days before a planned operation. Patients received 500 micrograms of the BCD-F9 monoclonal antibody or its F(ab')2 fragments containing 1 mCi of Iodin-123. Each preparation was given by a subcutaneous injection into the fingerwebs between the 2nd and 3rd fingers of both hands. Three static scintigrams were taken 4, 8 and 24 hours following injection of the radiolabelled antibodies. ILS results were always compared to histopathological findings and gave for the intact antibody a sensitivity of 83%, a specificity of 93% and an accuracy of 89%, the positive predictive value was 91% and the negative predictive value was 80%. On the other hand, when the F(ab')2 fragments were used the sensitivity of the ILS technique was 75%, the specificity was 100% while the accuracy was 86%, the positive predictive value was 100% and the negative predictive value was 75%.
Schatten
C
C
First Department of Obstetrics and Gynecology, University of Vienna, Austria.
Pateisky
N
N
Enzelsberger
H
H
Grouix
B
B
Mandeville
R
R
D000911:Antibodies, Monoclonal; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification; D007457:Iodine Radioisotopes; D008207:Lymphatic Metastasis; D011877:Radionuclide Imaging
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes