Renal responses to atrial natriuretic factor in hydrated and hydropenic dogs.
Atrial natriuretic factor (ANF 101-126) was compared to the standard diuretics, furosemide and hydrochlorothiazide, and to the vasodilator, acetylcholine in hydrated and dehydrated anesthetized dogs. ANF 101-126 (20 pmole/kg/min, ira) modestly reduced solute-free water clearance in water-loaded dogs and slightly lowered free water reabsorption in dehydrated animals. This pattern of responses most closely resembled those produce by 10 mg/kg, ira of the distally-acting diuretic, hydrochlorothiazide and a natriuretic dose of acetylcholine (2.5 micrograms/kg/min, ira). In contrast, the loop diuretic, furosemide (1 mg/kg, ira) drastically suppressed both free water clearance and reabsorption. ANF 101-126 produced changes in free water handling which were not readily distinguishable from those induced by either hydrochlorothiazide, a distally-acting diuretic, or acetylcholine, a vasodilator.
Seymour
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AA
Department of Pharmacology, Merck, Sharp and Dohme Research Laboratories, West Point, PA.
Smith
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SG
Mazack
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EK
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D003681:Dehydration / Q000378:metabolism; D004285:Dogs; D005260:Female; D005440:Fluid Therapy; D005665:Furosemide / Q000494:pharmacology; D006852:Hydrochlorothiazide / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects*; D007671:Kidney Concentrating Ability / Q000187:drug effects; D009318:Natriuresis / Q000187:drug effects
D006852:Hydrochlorothiazide; D005665:Furosemide; D009320:Atrial Natriuretic Factor; D000109:Acetylcholine