Meso-2,3-dimercaptosuccinic acid increases the inhibition of glutathione S-transferase activity from rat liver cytosol supernatants by di-n-butyltin dichloride.
Di-n-butyltin dichloride (DBTC) and tricyclohexyltin chloride (TCHTC) inhibited the glutathione S-transferase activity of rat liver cytosolic supernatants towards 1-chloro-2,4-dinitrobenzene. Meso-2,3-dimercaptosuccinic acid increased inhibition of glutathione S-transferase by DBTC but lowered inhibition of the enzyme by TCHTC.
Hennighausen
G
G
Merkord
J
J
D000818:Animals; D003600:Cytosol / Q000201:enzymology; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology*; D008297:Male; D009947:Organotin Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D004113:Succimer / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D014220:Trialkyltin Compounds / Q000633:toxicity
D009947:Organotin Compounds; D013438:Sulfhydryl Compounds; D014220:Trialkyltin Compounds; D004113:Succimer; D005982:Glutathione Transferase; C020735:dibutyldichlorotin