Chronic T cell lymphocytosis with large granular lymphocytes of helper (OKT4) phenotype.
A 54-year-old asymptomatic male patient was followed for more than 7 y and presented a constant T cell lymphocytosis without skin involvement or bone marrow depression. No clinical or haematological aggravation was noted during this follow-up. Morphologically, the cells were large granular lymphocytes strongly positive for beta-D-glucuronidase, negative for acid phosphatase and with features of T cells on transmission and scanning electron microscopy. The immunological studies of the lymphocytes showed the following parameters: E rosettes+, mouse rosettes-, SmIg-, OKT3+, OKT4+, OKT8-, OKT6-, Ia-, TdT-, NK-, HTLV-, decreased PHA and PWM stimulation, no interleukin 2 production and failure to enhance Ig synthesis in a PWM driven system. The karyotype was normal. This case of chronic T cell lymphocytosis with large granular lymphocytes helper profile and defect of helper function, not reported in the literature, may correspond to a distinct entity in the heterogeneous group of chronic T cell disorders.
Berrebi
A
A
Talmor
M
M
Vorst
E J
EJ
Shtalrid
M
M
Polliack
A
A
Nir
E
E
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral / Q000032:analysis; D001402:B-Lymphocytes; D002908:Chronic Disease; D017977:Deltaretrovirus / Q000276:immunology; D006651:Histocytochemistry; D006801:Humans; D007621:Karyotyping; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008218:Lymphocytosis / Q000097:blood / Q000235:genetics / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral