title: Treatment of unresectable or metastatic osteosarcoma with cisplatin or cisplatin-doxorubicin.
abstract: Responses and toxicity after treatment with cisplatin and cisplatin-doxorubicin were compared in two groups of patients with unresectable or metastatic osteosarcoma. Complete or partial responses developed in 3 of 18 individuals treated with cisplatin, and in 5 of 19 after the two-drug combination. Hematologic and gastrointestinal complications were more frequent and severe in patients who received both agents. The combined use of cisplatin and doxorubicin is justified for patients with unresectable or metastatic osteosarcoma at diagnosis because of the potential therapeutic benefits for these individuals.
authors.forename: C B
authors.initials: CB
authors.lastname: Pratt
authors.forename: J E
authors.initials: JE
authors.lastname: Champion
authors.forename: N
authors.initials: N
authors.lastname: Senzer
authors.forename: A A
authors.initials: AA
authors.lastname: Green
authors.forename: B
authors.initials: B
authors.lastname: Rao
authors.forename: E
authors.initials: E
authors.lastname: Douglass
authors.forename: W E
authors.initials: WE
authors.lastname: Meyer
authors.forename: D B
authors.initials: DB
authors.lastname: Crom
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D002648:Child; D002813:Chondrosarcoma / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage; D018219:Histiocytoma, Benign Fibrous / Q000188:drug therapy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D009325:Nausea / Q000139:chemically induced; D012516:Osteosarcoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary
chemical_list: D004317:Doxorubicin; D002945:Cisplatin