Myocardial protection.
Early studies of myocardial protection were designed to minimize ischemic injury. The next class and generation of investigations will most likely be designed to accelerate recovery following known myocardial injury. Such techniques will play an important role in allowing operations on acutely injured and ischemic myocardium and will be important in the treatment of postischemic injury when such injury occurs during the course of complex cardiac operations. Surgical aspects of myocardial metabolism are still rudimentary and many empiric observations require further exploration into the mechanisms by which such applications work.
Wechsler
A S
AS
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710.
Abd-Elfattah
A S
AS
Murphy
C E
CE
Salter
D R
DR
Brunsting
L A
LA
Goldstein
J P
JP
D000249:Adenosine Monophosphate / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002021:Buffers; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D002314:Cardioplegic Solutions / Q000008:administration & dosage / Q000627:therapeutic use; D002952:Citric Acid Cycle; D003326:Coronary Circulation; D003971:Diastole; D005609:Free Radicals; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006324:Heart Arrest, Induced / Q000379:methods; D006331:Heart Diseases / Q000517:prevention & control; D006335:Heart Injuries / Q000517:prevention & control*; D006801:Humans; D007036:Hypothermia, Induced; D007231:Infant, Newborn; D009203:Myocardial Infarction / Q000517:prevention & control*; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism; D010100:Oxygen / Q000008:administration & dosage / Q000627:therapeutic use; D010101:Oxygen Consumption; D013997:Time Factors
D000975:Antioxidants; D002021:Buffers; D002121:Calcium Channel Blockers; D002314:Cardioplegic Solutions; D005609:Free Radicals; D000249:Adenosine Monophosphate; D010100:Oxygen