title: [Offspring of patients with Down syndrome].
abstract: An incident of birth of a child in 16-year-old patient with typical phenotype of Down's syndrome is described. The karyotype of the proband is 47, XX + 21, while that of the child is 46, XX. Analysis of the literature data and the author's observations showed that the total ratio of trisomics and non-trisomics in the offspring of women with Down's syndrome is 9:18, which considerably differs from theoretically expected and suggests that selection against anomalous gametes exists.
authors.forename: D I
authors.initials: DI
authors.lastname: Kristesashvili
mesh_terms: D000293:Adolescent; D004314:Down Syndrome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome
vernacular_title: Potomstvo patsientok s bolezn'iu Dauna.