Aortic valve replacement with stentless porcine bioprostheses.
Aortic valve replacement with stentless porcine valve should provide superior hemodynamic results to stented porcine valve because the obstruction caused by the stent and the sewing ring is eliminated. In addition, the coronary sinuses of the recipient may allow for better dissipation of the mechanical stress to which the leaflets are subjected during diastole, thus enhancing durability of the heterograft. Aortic valve replacement with stentless glutaraldehyde-fixed aortic porcine bioprosthesis was carried out successfully in six young sheep. These animals were hemodynamically evaluated at 3 to 6 months after operation and found to have no resting gradients or any degree of aortic regurgitation. Explantation of the aortic heterograft revealed that it was well healed in the aortic root and had no evidence of any calcification. A clinical trial has been initiated and the results in the first five humans who underwent aortic valve replacement with a stentless porcine aortic bioprosthesis have been satisfactory.
David
T E
TE
Division of Cardiovascular Surgery, Toronto General Hospital, Ontario, Canada.
Ropchan
G C
GC
Butany
J W
JW
D000368:Aged; D000818:Animals; D001024:Aortic Valve Stenosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D001705:Bioprosthesis / Q000592:standards*; D006328:Cardiac Catheterization; D004195:Disease Models, Animal; D004452:Echocardiography; D005240:Feasibility Studies; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects / Q000401:mortality / Q000592:standards*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design; D012756:Sheep; D015607:Stents; D015996:Survival Rate