title: Comparative in vitro activity of A-56268.
abstract: The comparative in vitro activity of A-56268 was studied using 1,006 clinical isolates including streptococci, enterococci, staphylococci, Neisseria gonorrhoeae, Haemophilus influenzae and anaerobes. A-56268 showed activity comparable to that of erythromycin and was more active than josamycin and roxithromycin against erythromycin-sensitive aerobic and facultatively anaerobic gram-positive cocci. A-56268 was the most active macrolide against Clostridium spp. and Neisseria gonorrhoeae. Josamycin was more active than either A-56268 or erythromycin against the anaerobic gram-positive cocci and the Bacteroides fragilis group. Staphylococci moderately resistant or resistant to erythromycin (MIC 3.12-50 mg/l) remained susceptible to josamycin but not the other macrolides.
authors.affiliation: Department of Medical Microbiology, London Hospital Medical College, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Sefton
authors.forename: J P
authors.initials: JP
authors.lastname: Maskell
authors.forename: F J
authors.initials: FJ
authors.lastname: Yong
authors.forename: S J
authors.initials: SJ
authors.lastname: Chi
authors.forename: J D
authors.initials: JD
authors.lastname: Williams
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D017291:Clarithromycin; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D007933:Leucomycins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents; D007933:Leucomycins; D004917:Erythromycin; D017291:Clarithromycin