Surface marker characterization of EBV target cells in normal blood and tonsil B lymphocyte populations.
Human FACS-sorted B lymphocyte subpopulations were investigated for their susceptibility to immortalization by Epstein Barr virus (EBV). Only B cells reacting with the monoclonal antibody B2 were immortalized, whereas cells reacting with anti-human IgG or the monoclonal antibody BB2 were not responding. Cells positive or negative for IgM, IgD, Burkitt's lymphoma antigen (BLA), BB1, and HB2 were all transformed by EBV.
Aman
P
P
Gordon
J
J
Lewin
N
N
Nordström
M
M
Ehlin-Henriksson
B
B
Klein
G
G
Carstensson
A
A
D000954:Antigens, Surface / Q000032:analysis*; D001402:B-Lymphocytes / Q000145:classification* / Q000276:immunology; D002460:Cell Line; D002469:Cell Separation; D002472:Cell Transformation, Viral; D005434:Flow Cytometry; D006566:Herpesviridae Infections / Q000276:immunology; D004854:Herpesvirus 4, Human; D006801:Humans; D007113:Immunity, Innate; D008213:Lymphocyte Activation; D014066:Palatine Tonsil / Q000166:cytology*; D010641:Phenotype
D000954:Antigens, Surface