title: Atrial natriuretic hormone has biological effects in man at physiological plasma concentrations.
abstract: Whether atrial natriuretic hormone (ANH) has biological effects at physiological plasma levels in man is not known. Accordingly, we investigated the effects of a 3-h low dose infusion of human ANF (0.75 pmol/kg.min; i.e. 0.0023 micrograms/kg.min) in six normal men, whose sodium intake was normal while sitting, in a single blind, random order, placebo-controlled study. The ANF infusions induced changes in plasma ANH concentrations entirely within the range for normal subjects. The small increases in plasma ANH values were associated with a significant rise in urinary excretion of sodium, magnesium, calcium, and cGMP. PRA and plasma aldosterone concentrations uniformly decreased to 50% and 64% of placebo values, respectively. Systolic and mean arterial pressures fell significantly from preinfusion values during the ANH infusions. These findings constitute strong evidence that ANH is a hormone of physiological significance in the regulation of body fluid volumes in normal man.
authors.affiliation: Department of Endocrinology, Princess Margaret Hospital, Christchurch, New Zealand.
authors.forename: A M
authors.initials: AM
authors.lastname: Richards
authors.forename: D
authors.initials: D
authors.lastname: McDonald
authors.forename: M A
authors.initials: MA
authors.lastname: Fitzpatrick
authors.forename: M G
authors.initials: MG
authors.lastname: Nicholls
authors.forename: E A
authors.initials: EA
authors.lastname: Espiner
authors.forename: H
authors.initials: H
authors.lastname: Ikram
authors.forename: S
authors.initials: S
authors.lastname: Jans
authors.forename: S
authors.initials: S
authors.lastname: Grant
authors.forename: T
authors.initials: T
authors.lastname: Yandle
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D010919:Placebos; D011897:Random Allocation; D012084:Renin-Angiotensin System / Q000187:drug effects; D014563:Urodynamics / Q000187:drug effects
chemical_list: D010919:Placebos; D009320:Atrial Natriuretic Factor