Interaction of smooth muscle relaxant drugs with calmodulin and cyclic nucleotide phosphodiesterase.
Some smooth muscle relaxant drugs with an unknown mechanism of action have been tested for their interaction with calmodulin and with calmodulin-induced cyclic nucleotide phosphodiesterase (PDE) activity. The affinity of these drugs for calmodulin does not parallel their inhibitory effect on the calmodulin activation of PDE. The lack of parallelism could be due to a binding of the drugs to different sites on calmodulin; furthermore a binding of papaverine, octylonium bromide and felodipine to PDE molecule might also be considered to explain their inhibitory effect on PDE basal activity. The myolytic effect of octylonium bromide and pinaverium bromide may be due to their interaction with calmodulin-dependent systems.
Ronca-Testoni
S
S
Hrelia
S
S
Hakim
G
G
Rossi
C A
CA
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D001965:Bromides / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002147:Calmodulin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1; D004789:Enzyme Activation / Q000187:drug effects; D015736:Felodipine; D005275:Fendiline / Q000494:pharmacology; D009543:Nifedipine / Q000031:analogs & derivatives / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D010276:Parasympatholytics / Q000378:metabolism / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D014268:Trifluoperazine / Q000494:pharmacology
C035684:5-dimethylaminonaphthalene-1-sulfonyl-calmodulin; D001965:Bromides; D002147:Calmodulin; D010276:Parasympatholytics; D014268:Trifluoperazine; D010208:Papaverine; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1; D009543:Nifedipine; D015736:Felodipine; D005275:Fendiline; D002118:Calcium