Sphingomyelin synthesis in Hymenolepis diminuta (Cestoda).
Adult Hymenolepis diminuta incorporated label from L[U-14C]serine, [1-14C]palmitic acid, [1-14C]palmitoyl-CoA and cytidine-5'-diphospho[methyl-14C]choline into the various intermediates of sphingomyelin synthesis (ketosphingosine, dihydrosphingosine, sphingosine, ceramide and sphingomyelin). From the results it was concluded that H. diminuta possessed the five enzymes involved in sphingomyelin synthesis, namely serine palmitoyl-transferase, 3-oxosphinganine reductase, flavoprotein dihydrosphingosine reductase, sphingosine acyltransferase and ceramide choline-phosphotransferase.
Bankov
I
I
Barrett
J
J
D000217:Acyltransferases / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000818:Animals; D002518:Ceramides / Q000096:biosynthesis; D003566:Cytidine Diphosphate Choline / Q000378:metabolism; D002798:Diacylglycerol Cholinephosphotransferase / Q000378:metabolism; D006926:Hymenolepis / Q000201:enzymology / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism; D010171:Palmitoyl Coenzyme A / Q000378:metabolism; D012694:Serine / Q000378:metabolism; D051102:Serine C-Palmitoyltransferase; D013109:Sphingomyelins / Q000096:biosynthesis*; D013110:Sphingosine / Q000096:biosynthesis; D051049:Sphingosine N-Acyltransferase
D002518:Ceramides; D010169:Palmitic Acids; D013109:Sphingomyelins; D010171:Palmitoyl Coenzyme A; D019308:Palmitic Acid; D012694:Serine; D003566:Cytidine Diphosphate Choline; D010088:Oxidoreductases; D000429:Alcohol Oxidoreductases; C046333:3-dehydrosphinganine reductase; C046335:dihydrosphingosine reductase; D000217:Acyltransferases; D051049:Sphingosine N-Acyltransferase; D051102:Serine C-Palmitoyltransferase; D002798:Diacylglycerol Cholinephosphotransferase; D013110:Sphingosine