title: The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions.
abstract: To analyze expression of the 2H4 (CD45R) Ag on inflammatory cells in the central nervous system immune response, immunohistochemical staining with a panel of anti-T cell mAb was performed on central nervous system tissues from 12 patients with multiple sclerosis (MS) and 8 patients with viral encephalitis. Only rare cells were stained with anti-2H4 in MS plaques, plaque edges, and adjacent white matter, whereas 2H4+ cells were more numerous in viral encephalitis (p less than 0.001). By contrast, no quantitative differences were found between MS plaque edges and viral encephalitis with anti-4B4 (helper-inducer function associated), anti-CD4, anti-CD3, and anti-IL-2R mAb, although there were fewer CD8+ cells in MS (p less than 0.01). These data indicate that the 2H4 Ag is selectively decreased and, because it is associated with suppressor-inducer function of CD4+ cells, that there may be a defect in the down-regulation of the in situ immune response in MS.
authors.affiliation: Department of Pathology, Massachusetts General Hospital, Boston 02114.
authors.forename: R A
authors.initials: RA
authors.lastname: Sobel
authors.forename: D A
authors.initials: DA
authors.lastname: Hafler
authors.forename: E E
authors.initials: EE
authors.lastname: Castro
authors.forename: C
authors.initials: C
authors.lastname: Morimoto
authors.forename: H L
authors.initials: HL
authors.lastname: Weiner
mesh_terms: D000208:Acute Disease; D000328:Adult; D000943:Antigens, Differentiation / Q000032:analysis*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D001921:Brain / Q000276:immunology / Q000473:pathology; D002908:Chronic Disease; D004660:Encephalitis / Q000276:immunology / Q000473:pathology; D006561:Herpes Simplex / Q000276:immunology / Q000473:pathology; D006801:Humans; D017493:Leukocyte Common Antigens; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*
chemical_list: D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D017493:Leukocyte Common Antigens