title: Dopamine receptors regulate Met-enkephalin content in pituitary.
abstract: Met-enkephalin-like immunoreactive material (ME-LI) in the neurointermediate lobe of rat pituitary was dramatically altered by the long-term administration of drugs altering dopamine receptor activity. Treatment with the dopamine receptor antagonist haloperidol resulted in significant increases of ME-LI and treatment with the dopamine receptor agonist bromocriptine resulted in significant decreases of ME-LI in the neurointermediate pituitary. The treatments had considerably less effect on ME-LI in the anterior lobe of the pituitary. These results suggest that dopamine receptor activation or inhibition influences the content of ME-LI in the rat pituitary gland.
authors.forename: S R
authors.initials: SR
authors.lastname: George
authors.forename: M
authors.initials: M
authors.lastname: Kertesz
mesh_terms: D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D004744:Enkephalin, Methionine / Q000032:analysis*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D010903:Pituitary Gland, Anterior / Q000032:analysis*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology*; D009435:Synaptic Transmission
chemical_list: D011954:Receptors, Dopamine; D001971:Bromocriptine; D004744:Enkephalin, Methionine; D006220:Haloperidol