Factors involved in interferon-induced or cholera toxin-induced steroidogenesis in Y-1 mouse adrenal tumour cells.
In addition to its antiviral effect, interferon, at high concentrations, stimulates steroidogenesis and provokes cell rounding in Y-1 mouse adrenal tumour cells. This stimulation was inhibited by cytochalasin B and colchicine. In contrast, dibutyryl cAMP and cholera toxin, also able to induce steroid production and cell rounding, increased steroid production even in the presence of these cytoskeleton-disrupting agents. The initial trigger for interferon or cholera toxin thus probably involves a distinct receptor organization. However, since both inducers increased cAMP synthesis in this differentiated cell line, the further metabolic steps of ketosteroid production could be the same.
Matsuguchi
M
M
Moreau
L
L
Rousset
S
S
Chany
C
C
D000310:Adrenal Gland Neoplasms / Q000378:metabolism*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D003994:Bucladesine / Q000494:pharmacology; D002087:Butyrates; D002460:Cell Line; D002772:Cholera Toxin / Q000494:pharmacology*; D003078:Colchicine / Q000494:pharmacology; D003571:Cytochalasin B / Q000494:pharmacology; D003599:Cytoskeleton / Q000187:drug effects; D007370:Interferon Type I / Q000494:pharmacology*; D007664:Ketosteroids / Q000096:biosynthesis*; D051379:Mice
D002087:Butyrates; D007370:Interferon Type I; D007664:Ketosteroids; D003571:Cytochalasin B; D003994:Bucladesine; D002772:Cholera Toxin; D001120:Arginine; C033018:arginine butyrate; D003078:Colchicine