[Endogenous opioid system in the realization of the analgesic effect of alpha-tocopherol in reference to algomenorrhea].
Beta-endorphin-like immunoreactivity was studied in 7 patients with algomenorrhea during pain attack and 15 minutes after alpha-tocopherol administration with a therapeutic aim (till the analgetic effect was reached). There was an increase in beta-endorphin-like immunoreactivity after alpha-tocopherol administration. Naloxone administration to 9 patients with algomenorrhea of various etiology resumed the pain. The effect of alpha-tocopherol application for pain relief depended on the pathogenesis of algomenorrhea. At the same time naloxone administration failed to resume the pain in patients, in whom alpha-tocopherol had a strong analgetic effect. It is assumed that the endogenous opioid system participates in alpha-tocopherol effect on pain relief in patients with algomenorrhea.
Kryzhanovskiĭ
G N
GN
Bakuleva
L P
LP
Luzina
N L
NL
Vinogradov
V A
VA
Iarygin
K N
KN
D000328:Adult; D000698:Analgesia / Q000379:methods*; D002908:Chronic Disease; D004412:Dysmenorrhea / Q000097:blood* / Q000188:drug therapy; D004723:Endorphins / Q000097:blood*; D005260:Female; D006801:Humans; D008598:Menstruation / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*; D001615:beta-Endorphin / Q000097:blood
D004723:Endorphins; D014810:Vitamin E; D009270:Naloxone; D001615:beta-Endorphin; D024502:alpha-Tocopherol; D024505:Tocopherols
Endogennaia opioidnaia sistema v realizatsii anal'geticheskogo éffekta al'fa-tokoferola na primere al'gomenorei.