[Effect of lithium preparations on cardiac arrhythmias due to strophanthin in waking rats].
It was shown in experiments on conscious rats that intravenous injection of strophanthine in toxic doses provokes heart arrhythmias and death of the animals. Lithium drugs (lithium chloride and lithium hydroxybutyrate) injected during arrhythmias led to a short-lived effect of heart rhythm normalization. Lithium hydroxybutyrate was more effective if administered shortly after strophanthine injection, reducing the latter's cardiotoxic effect and preventing the death of the majority of the animals.
Sobieva
Z I
ZI
Karpova
M N
MN
Kryzhanovskaia
E G
EG
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D002712:Chlorides / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004562:Electrocardiography; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D008094:Lithium / Q000627:therapeutic use*; D018021:Lithium Chloride; D008297:Male; D009942:Organometallic Compounds; D051381:Rats; D012996:Solutions; D013328:Strophanthins / Q000633:toxicity*; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects*
D002712:Chlorides; D006885:Hydroxybutyrates; D009942:Organometallic Compounds; D012996:Solutions; D013328:Strophanthins; C022826:lithium hydroxybutyrate; D008094:Lithium; D018021:Lithium Chloride; C029082:strophanthin K
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