Adenosine-homocysteine interactions in controlling cyclic AMP in rat brain cortical slices.
Preincubation of rat brain cortical slices with homocysteine resulted in a reduction of the cyclic AMP response to subsequently added noradrenaline or isoproterenol. There was no effect of homocysteine on the adenosine response, nor of added S-adenosyl homocysteine on any of the responses studied. The results are interpreted in terms of binding of endogenous adenosine by the enzyme S-adenosylhomocysteinase, and provide further evidence for the controlling role of adenosine on cerebral cyclic AMP production.
Newman
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D000241:Adenosine / Q000502:physiology*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002540:Cerebral Cortex / Q000032:analysis; D000242:Cyclic AMP / Q000032:analysis*; D006710:Homocysteine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012435:S-Adenosylhomocysteine / Q000494:pharmacology
D006710:Homocysteine; D012435:S-Adenosylhomocysteine; D000242:Cyclic AMP; D000241:Adenosine