title: [The contractile function and calcium-transport system of the myocardium in aging].
abstract: Experiments with different species of animals and different models (in situ heart, isolated perfused heart, isolated papillary muscle) revealed a reduction of functional capacity of ageing heart. A decrease of Ca2+ uptake by sarcoplasmic reticulum and mitochondria and diverse age-dependent shifts were found in sarcolemma. The data obtained suggest that the development of the cardiac contractile function disorders in ageing largely depends of the age-related changes in the Ca2+ transport system.
authors.forename: V V
authors.initials: VV
authors.lastname: Frol'kis
authors.forename: R A
authors.initials: RA
authors.lastname: Frol'kis
authors.forename: L S
authors.initials: LS
authors.lastname: Mkhitarian
authors.forename: V G
authors.initials: VG
authors.lastname: Shevchuk
authors.forename: V E
authors.initials: VE
authors.lastname: Fraĭfel'd
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000375:Aging / Q000502:physiology*; D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D002415:Cats; D004285:Dogs; D004558:Electric Stimulation; D006439:Hemodynamics; D066298:In Vitro Techniques; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D010210:Papillary Muscles / Q000502:physiology; D011817:Rabbits; D051381:Rats; D012964:Sodium / Q000378:metabolism
chemical_list: D012964:Sodium; D000251:Adenosine Triphosphatases; D002118:Calcium
vernacular_title: Sokratitel'naia funktsiia i kal'tsiĭ-transportnaia sistema miokarda pri starenii.