Nocturnal fluctuations of plasma atrial natriuretic peptide in normotensive and hypertensive men.
Plasma levels of immunoreactive atrial natriuretic peptides (ANP) were measured at 10-min intervals during night-sleep in 4 normotensive and in 4 moderate, essential hypertensive subjects. The mean ANP levels ranged from 24.3 to 27.9 pg.ml-1 for the normal subjects. These mean levels were not significantly different in the hypertensive subjects (range: 26.3 to 37.2 pg.ml-1). Fluctuations, often of small amplitude, were observed around this mean, without any defined periodicity. Changes in plasma ANP were not associated with changes in heart rate. Analysis of the ANP profiles and the concomitant sleep stage patterns did not reveal any temporal relationship between ANP fluctuations and specific sleep stages or waking periods. The ANP profiles did not differ between the groups, which indicates no abnormality in ANP secretion in moderate essential hypertension.
Follenius
M
M
Laboratoire de Physiologie, CNRS/INRS, Strasbourg, France.
Brandenberger
G
G
Simon
C
C
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D002940:Circadian Rhythm; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D012016:Reference Values; D012894:Sleep Stages / Q000502:physiology; D014851:Wakefulness / Q000502:physiology
D009320:Atrial Natriuretic Factor