Degradation of alpha-actinin during Ca2+-sensitive proteolysis of myofibrils.
The noted loss of alpha-actinin from the Z-line of myofibrils during post-mortem autolysis, probably following the action of calcium-activated protease, has previously been attributed to its release without degradation. This report shows that in isolated myofibrils alpha-actinin is proteolysed in a Ca2+-sensitive manner presumably via the action of calcium-activated protease.
Kulesza-Lipka
D
D
Jakubiec-Puka
A
A
D000185:Actinin / Q000378:metabolism*; D000818:Animals; D001329:Autolysis / Q000378:metabolism; D002118:Calcium / Q000494:pharmacology; D002154:Calpain; D010450:Endopeptidases / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D009210:Myofibrils / Q000187:drug effects / Q000378:metabolism*; D011480:Protease Inhibitors / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D011480:Protease Inhibitors; D000185:Actinin; D010450:Endopeptidases; D002154:Calpain; D002118:Calcium