Glomerulonephritis and chronic myelogenous leukemia.
An adolescent with chronic myelogenous leukemia (CML) developed gross hematuria. Evaluation included renal biopsy revealing a proliferative glomerulonephritis with mesangial deposits of immunoglobulins A and G. An association between CML and immune-complex glomerulonephritis has not been previously reported and may represent a paraneoplastic phenomenon.
Springate
J E
JE
Department of Pediatrics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo.
Brecher
M
M
Brentjens
J
J
Feld
L G
LG
D000293:Adolescent; D000936:Antigen-Antibody Complex / Q000032:analysis; D005455:Fluorescent Antibody Technique; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000473:pathology; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007105:Immune Complex Diseases / Q000150:complications* / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications*; D008297:Male
D000936:Antigen-Antibody Complex