A comparative study of benzoyl peroxide and clindamycin phosphate for treating acne vulgaris.
A water based 5% benzoyl peroxide gel (Benzac W5) was compared with topical 1% clindamycin phosphate solution (Cleocin T) in the treatment of acne vulgaris using a randomized, investigator blind study design. Lesion counts were significantly reduced in both treatment groups over the 12-week study period; however, the reduction of total lesions produced by benzoyl peroxide gel was significantly greater than that produced by clindamycin phosphate (P less than 0.05). Clindamycin phosphate had a milder effect on the skin surface in terms of peeling and drying than the benzoyl peroxide gel.
Swinyer
L J
LJ
University of Utah, Salt Lake City.
Baker
M D
MD
Swinyer
T A
TA
Mills
O H
OH
D000152:Acne Vulgaris / Q000188:drug therapy*; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D001585:Benzoyl Peroxide / Q000627:therapeutic use*; D002981:Clindamycin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D010545:Peroxides / Q000627:therapeutic use*; D011897:Random Allocation
D010545:Peroxides; D002981:Clindamycin; C007084:clindamycin phosphate; D001585:Benzoyl Peroxide