Blockade of intrathecal 5-hydroxytryptamine-induced antinociception in rats by noradrenaline depletion.
The analgesic effect of 5-hydroxytryptamine (5-HT, 200 and 250 micrograms/kg) administered into the lumbar intrathecal space of rats was blocked in the tail-flick, hot-plate and shock titration tests of nociception when the animals had previously been treated with N-2-chloroethyl-N-ethyl-2-bromobenzylamine (DSP4), which depletes noradrenaline in the spinal cord. These results suggest an important modulatory role of noradrenaline upon spinal 5-HT mechanisms.
Minor
B G
BG
Post
C
C
Archer
T
T
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D007278:Injections, Spinal; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D010146:Pain / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology* / Q000502:physiology*; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission
D000700:Analgesics; D012701:Serotonin; D009638:Norepinephrine