Presynaptic localization of B-50 phosphoprotein: the (ACTH)-sensitive protein kinase substrate involved in rat brain polyphosphoinositide metabolism.
This study describes the ultrastructural localization in rat hippocampal tissue in situ and in isolated synaptosomes of the brain-specific phosphoprotein B-50, using affinity purified anti-B-50 immunoglobulins (IgGs). Evidence is presented for the presynaptic localization of B-50 in rat brain. Given this specific localization a model is presented outlining the presumed function of the B-50 protein in the membrane and describing possible neuromodulation by adrenocorticotropin hormone (ACTH)-like peptides.
Gispen
W H
WH
Leunissen
J L
JL
Oestreicher
A B
AB
Verkleij
A J
AJ
Zwiers
H
H
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D005455:Fluorescent Antibody Technique; D019922:GAP-43 Protein; D006624:Hippocampus / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013570:Synaptic Membranes / Q000378:metabolism*; D009435:Synaptic Transmission; D013574:Synaptosomes / Q000378:metabolism
D019922:GAP-43 Protein; D010750:Phosphoproteins