title: [Hepatitis A foci in children's collectives studied by using clinico-biochemical, virological and serological diagnostic methods].
abstract: In 4 foci of hepatitis A (HA) at children's institutions in Moscow 218 children and 30 staff members were examined. Simultaneously with clinico-biochemical studies, specific IgM and IgG in the blood and hepatitis A virus (HAV) antigen in feces were determined by radioimmunoassay. Different forms of HA were detected in 29.1% of children in kindergartens, 19.4% of school children and 3.3% of adults, which was due to great differences in the size of the immune stratum among them (IgG to HAV was detected in 8-10% of children aged 3-6 years and in 83% of adults). In 2/3 of children with HA in the foci the disease was not accompanied by jaundice, 1/5 of them having the inapparent form of this infection. In 45% of the patients HAV antigen was detected in feces, irrespective of the form of HA, 5-14 days before the appearance of hyperfermentemia, and in 2/3 of them this antigen was also detected during the first 6 days after that. Simultaneously with an increase in aminotransferase activity, all of the HA patients showed the presence of specific IgM in their blood.
authors.forename: I V
authors.initials: IV
authors.lastname: Shakhgil'dian
authors.forename: E Zh
authors.initials: EZh
authors.lastname: Zhylkybaev
authors.forename: V M
authors.initials: VM
authors.lastname: Stakhanova
authors.forename: N V
authors.initials: NV
authors.lastname: Doroshenko
authors.forename: D M
authors.initials: DM
authors.lastname: Braginskiĭ
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002648:Child; D002656:Child Day Care Centers; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000453:epidemiology; D004197:Disease Reservoirs; D005243:Feces / Q000382:microbiology; D006506:Hepatitis A / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D009031:Moscow; D010614:Pharynx / Q000276:immunology; D012698:Serologic Tests; D013997:Time Factors; D014505:Urban Population
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral
vernacular_title: Izuchenie ochagov gepatita A v detskikh kollektivakh s primeneniem kliniko-biokhimicheskikh, virusologicheskikh i serologicheskikh metodov diagnostiki.