title: A stable isotope study of copper absorption in young men: effect of phytate and alpha-cellulose.
abstract: A sixty-three day study was conducted with young men confined to a metabolic unit to study the effects of alpha-cellulose and phytate on copper absorption. Copper absorption was determined with 65Cu, a stable isotope of copper, during each of 3 dietary treatments (basal diet, basal diet + alpha-cellulose, or basal diet + phytate). The addition of alpha-cellulose or phytate to the basal diet did not affect copper absorption. Average copper absorption was 35.0% from the basal diet, 34.1% from the diet with 0.5 g alpha-cellulose per kg body weight added, and 31.4% from the diet with 2.34 g of phytate as sodium phytate added to the diet. Copper absorption was significantly different between subjects and averaged 44.1%, 26.8%, 33.4%, and 29.5% in individual subjects. The results suggest that high levels of either alpha-cellulose or phytate do not have marked effects on copper absorption, but copper absorption differs between individuals.
authors.forename: J R
authors.initials: JR
authors.lastname: Turnlund
authors.forename: J C
authors.initials: JC
authors.lastname: King
authors.forename: B
authors.initials: B
authors.lastname: Gong
authors.forename: W R
authors.initials: WR
authors.lastname: Keyes
authors.forename: M C
authors.initials: MC
authors.lastname: Michel
mesh_terms: D000328:Adult; D001682:Biological Availability; D002482:Cellulose / Q000494:pharmacology; D003300:Copper / Q000097:blood / Q000378:metabolism*; D004043:Dietary Fiber / Q000494:pharmacology*; D005243:Feces / Q000032:analysis; D005527:Food, Fortified; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007554:Isotopes; D008297:Male; D010833:Phytic Acid / Q000494:pharmacology*
chemical_list: D004043:Dietary Fiber; D007554:Isotopes; D003300:Copper; D010833:Phytic Acid; D002482:Cellulose