Increase in nigral type II benzodiazepine recognition sites following striatonigral denervation.
In the rat substantia nigra Type II benzodiazepine recognition sites (measured as the portion of [3H]flunitrazepam binding which remain after the addition of 2 X 10(-7) M Cl 218872) represent 50% of the total benzodiazepine recognition sites. The density of Type II sites was increased by 35% following the degeneration of the striatonigral afferents induced by the intrastriatal injection of kainic acid. On the other hand the same lesion failed to change the density of the remaining nigral Type I sites. The results indicate that denervation induces supersensitivity to nigral Type II benzodiazepine recognition sites.
Porceddu
M L
ML
Corda
M G
MG
Sanna
E
E
Biggio
G
G
D000818:Animals; D002243:Carbolines / Q000378:metabolism; D003342:Corpus Striatum / Q000502:physiology; D003714:Denervation; D005445:Flunitrazepam / Q000378:metabolism; D007608:Kainic Acid; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D011724:Pyridazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000378:metabolism*; D013378:Substantia Nigra / Q000378:metabolism* / Q000502:physiology
D002243:Carbolines; D011724:Pyridazines; D011963:Receptors, GABA-A; D005445:Flunitrazepam; C021604:CL 218872; C024915:beta-carboline-3-carboxylic acid ethyl ester; D007608:Kainic Acid