title: Role of Langerhans cells in the infection of the guinea-pig epidermis with foot-and-mouth disease virus.
abstract: In guinea-pig infected with foot-and-mouth disease virus (FMDV), Langerhans cells in the foot pads increase in number and show viral antigens 24 hours post-inoculation, preceding appearance of virus in epithelial cells and vesiculation. This observation suggests that Langerhans cells may be engaged in virus transport from the blood to the non vascularized epidermis.
authors.forename: W
authors.initials: W
authors.lastname: di Girolamo
authors.forename: M
authors.initials: M
authors.lastname: Salas
authors.forename: R P
authors.initials: RP
authors.lastname: Laguens
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D005537:Aphthovirus / Q000276:immunology*; D002452:Cell Count; D004817:Epidermis / Q000276:immunology / Q000382:microbiology; D005455:Fluorescent Antibody Technique; D005536:Foot-and-Mouth Disease / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D006168:Guinea Pigs; D007801:Langerhans Cells / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
chemical_list: D000956:Antigens, Viral