A region of the Herpesvirus saimiri genome required for oncogenicity.
Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.
Desrosiers
R C
RC
Bakker
A
A
Kamine
J
J
Falk
L A
LA
Hunt
R D
RD
King
N W
NW
D000818:Animals; D001029:Aotus trivirgatus; D004274:DNA, Recombinant / Q000378:metabolism; D004279:DNA, Viral / Q000235:genetics; D005814:Genes, Viral; D006566:Herpesviridae Infections / Q000235:genetics; D006567:Herpesvirus 2, Saimiriine / Q000235:genetics*; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000382:microbiology; D009857:Oncogenes; D014412:Tumor Virus Infections / Q000235:genetics
D004274:DNA, Recombinant; D004279:DNA, Viral