Chronic intrathecal cannulation affects hypothalamic beta-endorphin and met-enkephalin concentrations.
Beta-endorphin concentrations decrease and met-enkephalin concentrations increase in the hypothalamus of rats bearing a chronic intrathecal cannula. The modification of the concentrations of beta-endorphin is already present on day 1 after surgery, whereas met-enkephalin is affected starting on day 6, and both peptides are still modified on day 10. These results indicate that chronically cannulated rats are not to be considered normal animals.
Rovati
L C
LC
Department of Pharmacology, School of Medicine, University of Milano, Italy.
Sacerdote
P
P
Bianchi
M
M
Panerai
A E
AE
D000818:Animals; D002404:Catheterization; D004744:Enkephalin, Methionine / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin / Q000378:metabolism*
D004744:Enkephalin, Methionine; D001615:beta-Endorphin