Allelism in the HLA class I multigene family.
Recent data on the structure of functional HLA class I genes shows that, at least at the HLA-A locus, the allelic genes are more related to each other than to HLA genes from other loci. This "A-ness" is discernible at the protein sequence level but much more evident when nucleotide sequences are compared; the homology is particularly striking in the 3' non-coding region. Genes coding for the same HLA specificity in different genetic backgrounds show no obvious difference, although in one case the 3' flanking regions are clearly different; the restriction maps around the HLA-A3 and HLA-AW24 genes are also compared to see whether the chromosomal environments of these two genes are recognizably similar.
Sodoyer
R
R
Nguyen
C
C
Strachan
T
T
Santoni
M J
MJ
Damotte
M
M
Trucy
J
J
Jordan
B R
BR
D000483:Alleles; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis; D004262:DNA Restriction Enzymes / Q000378:metabolism; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens; D006801:Humans; D051379:Mice
D006680:HLA Antigens; D015234:HLA-A Antigens; D004247:DNA; D004262:DNA Restriction Enzymes