title: HLA-DRw6 as a risk factor for active cytomegalovirus but not for herpes simplex virus infection after renal allograft transplantation.
abstract: To study genetically determined susceptibility to cytomegalovirus and herpes simplex virus infections in patients given renal transplants a prospective study was performed of 68 consecutive patients receiving their first cadaveric kidney allograft. The recipients positive for HLA-DRw6 showed a significantly increased incidence of active cytomegalovirus infection as early as the 10th week after transplantation (p less than 0.05). No relation with other human leucocyte antigens was found, nor did a correlation exist between HLA typing and the incidence of herpes simplex virus infections. Furthermore, recipients positive for HLA-DRw6 with secondary cytomegalovirus infections excreted infectious virus more often (p less than 0.01) and showed more clinical symptoms (p less than 0.01) than a comparable group of recipients negative for HLA-DRw6. These observations may have practical implications for the treatment of patients who have had renal transplant operations.
authors.forename: H W
authors.initials: HW
authors.lastname: Roenhorst
authors.forename: A M
authors.initials: AM
authors.lastname: Tegzess
authors.forename: J M
authors.initials: JM
authors.lastname: Beelen
authors.forename: J M
authors.initials: JM
authors.lastname: Middeldorp
authors.forename: T H
authors.initials: TH
authors.lastname: The
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000382:microbiology; D005260:Female; D006084:Graft Rejection; D006680:HLA Antigens / Q000032:analysis; D015808:HLA-DR6 Antigen; D006561:Herpes Simplex / Q000276:immunology* / Q000382:microbiology; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012306:Risk; D013997:Time Factors
chemical_list: D006680:HLA Antigens; D015808:HLA-DR6 Antigen; D000949:Histocompatibility Antigens Class II