Effect of captopril on Na-K ATPase and Mg ATPase activities of erythrocyte ghost membranes.
Captopril has a known hypotensive action derived from the inhibition of the converting enzyme (Kininase II). To investigate whether other mechanism may contribute to vasodilation, Na-K ATPase and Mg ATPase activities on ghost red blood cells membranes were examined in the presence of the drug. The results show a stimulation of Mg ATPase activity and an inhibition of Na-K ATPase activity in a concentration dependent manner. The latter action does not seem to be related to a vasodilator effect.
Santoro
F M
FM
de la Riva
I J
IJ
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D017301:Ca(2+) Mg(2+)-ATPase; D002216:Captopril / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000201:enzymology*; D006801:Humans; D066298:In Vitro Techniques; D010042:Ouabain / Q000494:pharmacology; D011392:Proline / Q000031:analogs & derivatives*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D010042:Ouabain; D011392:Proline; D002216:Captopril; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase