Ketanserin does not prevent ACTH-induced hypertension in sheep.
The role of serotonin (5HT) in the pathogenesis of ACTH-induced hypertension in sheep has been examined. The pressor responses to injections of 5HT (0.1-30 micrograms/kg) were similar in normotensive and hypertensive sheep. Prior treatment with the 5HT2 receptor antagonist ketanserin had no effect on the development of hypertension produced by ACTH administration.
Nelson
M A
MA
Coghlan
J P
JP
Denton
D A
DA
Whitworth
J A
JA
Scoggins
B A
BA
D000324:Adrenocorticotropic Hormone / Q000037:antagonists & inhibitors*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006973:Hypertension / Q000503:physiopathology* / Q000517:prevention & control; D007650:Ketanserin; D010880:Piperidines / Q000494:pharmacology*; D012701:Serotonin / Q000502:physiology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D012756:Sheep
D010880:Piperidines; D012702:Serotonin Antagonists; D012701:Serotonin; D000324:Adrenocorticotropic Hormone; D007650:Ketanserin