Epidermal growth factor receptors in different skin tumors.
Specific binding of 125I-labeled epidermal growth factor (EGF) was measured in 62 skin tumors of different severity. Within a group of 28 benign tumors, 11 of 15 condylomata acuminata were receptor positive, whereas the investigated mesenchymal tumors and normal skin as a control were receptor negative. 6 of 18 basal cell epitheliomas bound EGF specifically. In the group of precancerous and malignant skin tumors, 7 of 8 squamous cell carcinomas had the highest number of EGF binding sites and a high affinity state, whereas 5 malignant melanomas were receptor negative. The clinical relevance of these findings is not yet clear due to the short follow-up of the patients.
Bauknecht
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Gross
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Hagedorn
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D001665:Binding Sites; D002280:Basal Cell Carcinoma / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000032:analysis; D003218:Condylomata Acuminata / Q000032:analysis; D004815:Epidermal Growth Factor / Q000032:analysis*; D066246:ErbB Receptors; D006801:Humans; D007457:Iodine Radioisotopes; D008545:Melanoma / Q000032:analysis; D011956:Receptors, Cell Surface / Q000032:analysis*; D012867:Skin / Q000032:analysis; D012871:Skin Diseases / Q000378:metabolism; D012878:Skin Neoplasms / Q000032:analysis*
D007457:Iodine Radioisotopes; D011956:Receptors, Cell Surface; D004815:Epidermal Growth Factor; D066246:ErbB Receptors