[Effect of hydrocortisone on neuromuscular transmission in the frog skeletal muscles].
Hydrocortisone (1.10(-7)-1.10(-5) M/l) in vitro experiments on frog's muscle in conditions of preliminary curarization increases dose-dependently the quantum content of e.p.p., affecting neither membrane potential, nor input resistance, nor sensitivity to acetylcholine of the membrane of m. sartorius fibers. Hydrocortisone in conditions of magnesium block of neuro-muscular transmission does not affect the evoked transmission. Hydrocortisone seems to facilitate the evoked quantum acetylcholine secretion only in the presence of curare and in conditions of initial high quantum content of e.p.p. The mechanism of hydrocortisone decurarization effect on neuro-muscular transmission is mainly of a presynaptic nature.
Poletaev
G I
GI
Volkov
E M
EM
Akhtiatova
D A
DA
Chikin
A V
AV
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D011895:Rana ridibunda; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors; D014403:Tubocurarine / Q000494:pharmacology
D008274:Magnesium; D000109:Acetylcholine; D002118:Calcium; D014403:Tubocurarine; D006854:Hydrocortisone
Vliianie gidrokortizona na nervno-myshechnuiu peredachu v skeletnykh myshtsakh liagushki.