title: A comparison between two commercially available activators for determining the partial thromboplastin time.
abstract: Activators that are used to determine the activated partial thromboplastin time should be sensitive enough to detect mild deficiencies of coagulation factors in a reproducible fashion. We compared two commercially available activators--a newly modified preparation of ellagic acid activator and a silica activator. Both reagents produced results that were reproducible over a broad range of concentrations of factors involved in the intrinsic coagulation pathway. The ellagic acid activator was more sensitive in detecting a partial deficiency of nearly all of these factors.
authors.forename: L G
authors.initials: LG
authors.lastname: Smith
authors.forename: C S
authors.initials: CS
authors.lastname: Kitchens
mesh_terms: D000328:Adult; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D004610:Ellagic Acid; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D012822:Silicon Dioxide
chemical_list: D001779:Blood Coagulation Factors; D004610:Ellagic Acid; D012822:Silicon Dioxide