Quantitative structure-activity relationships of cysteine hydrolases. Ficin hydrolysis of X-phenyl-N-methanesulfonyl glycinates.
The hydrolysis of ficin of 33 X-Phenyl-N-methanesulfonyl glycinates has been studied. The resulting Km-values have been used to derive a quantitative structure-activity relationship (QSAR). The QSAR for ficin is compared with QSAR for other cysteine hydrolases. The comparisons show that although there are specific differences, overall the reaction mechanisms are very similar.
Carotti
A
A
Raguseo
C
C
Hansch
C
C
D001555:Benzene Derivatives; D055598:Chemical Phenomena; D002621:Chemistry; D010450:Endopeptidases; D005361:Ficain; D006867:Hydrolases; D006868:Hydrolysis; D007700:Kinetics; D008698:Mesylates; D013329:Structure-Activity Relationship
D001555:Benzene Derivatives; D008698:Mesylates; C035617:phenylmethanesulfonic acid; D006867:Hydrolases; D010450:Endopeptidases; D005361:Ficain