[Acute toxicity and radioprotective effectiveness of gammaphos on intramuscular administration to mice].
In experiments on mice it was shown that acute toxicity of gammaphos (WR-2721) was 790 mg/kg and 862 mg-kg after intraperitoneal and intramuscular administration, respectively. Gammaphos in the dose of 100 mg/kg, injected intramuscularly, increased the radioresistance of mice in nearly the same way as cystamine, in the dose of 150 mg/kg, did. The increase in the dose of gammaphos up to 200 or 300 mg/kg, injected intramuscularly, enhanced the radioprotective effect. No change was observed in the radioprotective efficiency of gammaphos after intramuscular injection as compared to intraperitoneal administration of the protective agent in the same dose.
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D004999:Amifostine / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D007273:Injections, Intramuscular; D008297:Male; D051379:Mice; D009946:Organothiophosphorus Compounds / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity
D003037:Cobalt Radioisotopes; D009946:Organothiophosphorus Compounds; D011837:Radiation-Protective Agents; D004999:Amifostine
Ostraia toksichnost' i radiozashchitnaia éffektivnost' gammafosa, vvedennogo vnutromyshechno, u mysheĭ.