Administration of silica prevents diabetes in BB-rats.
Administration of silica to young BB-rats almost completely prevented the development of spontaneous diabetes. Only 1 of 31 silica-treated rats developed hyperglycemia, whereas 9 of 31 in the untreated group did so. Since silica is highly specific in its action against macrophages, our observations indicate an important role of these cells in the pathogenesis of the disease.
Oschilewski
U
U
Kiesel
U
U
Kolb
H
H
D000818:Animals; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006943:Hyperglycemia / Q000209:etiology; D008264:Macrophages / Q000276:immunology; D008297:Male; D051381:Rats; D012822:Silicon Dioxide / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000276:immunology
D012822:Silicon Dioxide