title: Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa. One gene codes for both the cytosolic and mitochondrial forms.
abstract: Cyclophilin (cyclosporin A-binding protein) has a dual localization in the mitochondria and in the cytosol of Neurospora crassa. The two forms are encoded by a single gene which is transcribed into mRNAs having different lengths and 5' termini (approximately 1 and 0.8 kilobases). The shorter mRNA specifies the cytosolic protein consisting of 179 amino acids. The longer mRNA is translated into a precursor polypeptide with an amino-terminal extension of 44 amino acids which is cleaved in two steps upon entry into the mitochondrial matrix. Neurospora cyclophilin shows about 60% sequence homology to human and bovine cyclophilins.
authors.affiliation: Institut für Physiologische Chemie der Universität München, Federal Republic of Germany.
authors.forename: M
authors.initials: M
authors.lastname: Tropschug
authors.forename: D W
authors.initials: DW
authors.lastname: Nicholson
authors.forename: F U
authors.initials: FU
authors.lastname: Hartl
authors.forename: H
authors.initials: H
authors.lastname: Köhler
authors.forename: N
authors.initials: N
authors.lastname: Pfanner
authors.forename: E
authors.initials: E
authors.lastname: Wachter
authors.forename: W
authors.initials: W
authors.lastname: Neupert
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D003001:Cloning, Molecular; D003524:Cyclosporins / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D004271:DNA, Fungal / Q000235:genetics; D005796:Genes; D005800:Genes, Fungal; D007700:Kinetics; D008928:Mitochondria / Q000378:metabolism*; D008969:Molecular Sequence Data; D009491:Neurospora / Q000235:genetics*; D009492:Neurospora crassa / Q000235:genetics* / Q000378:metabolism; D019696:Peptidylprolyl Isomerase
chemical_list: D002352:Carrier Proteins; D003524:Cyclosporins; D004271:DNA, Fungal; D019696:Peptidylprolyl Isomerase