title: On the origin and control of C3NeF.
abstract: Nephritic factors are a relatively recent addition to the growing list of autoantibodies. C3NeF was the first of these to be described and acts by stabilizing the alternative pathway C3/C5 convertase. IgG and IgM C3NeF as well as anti-idiotypic antibody to C3NeF, may be found in normal individuals at all ages. In addition, internal image anti-idiotypic antibody can also be demonstrated in patients with glomerulonephritis. Thus, C3NeF appears to fulfill all of the criteria for being a product of normal B-cell function. The potential dysregulation of this process and the role of C3NeF in glomerulonephritis remains theoretical at best.
authors.affiliation: Department of Pediatrics, SUNY Health Science Center, Syracuse 13210.
authors.forename: R E
authors.initials: RE
authors.lastname: Spitzer
authors.forename: A E
authors.initials: AE
authors.lastname: Stitzel
mesh_terms: D001323:Autoantibodies / Q000096:biosynthesis*; D015432:Glomerulonephritis, Membranoproliferative / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D012016:Reference Values
chemical_list: D001323:Autoantibodies