[Characteristics of the clinical and immunologic safety of inactivated influenza vaccines in children undergoing multiple immunizations].
In a strictly controlled epidemiological trial on 12,643 school children aged 11-14 years the reactogenic properties and safety of killed influenza chromatographic vaccine under the conditions of multiple immunization were studied. A single immunization dose of the vaccine (0.2 ml) contained the hemagglutinins of influenza viruses A/Philippines/82 (H3N3) and A/Kiev/59/79 (H1N1), 3.5 micrograms each. The preparation was introduced by means of a jet injector. The vaccine was shown to be clinically and immunologically safe under the conditions of the regular multiple immunization of children over the period of 4 years.
Vasil'eva
R I
RI
Merkur'eva
L A
LA
Iatsenko
V G
VG
Vasil'eva
A M
AM
Shvager
M M
MM
D000293:Adolescent; D000917:Antibody Formation; D002648:Child; D004341:Drug Evaluation; D006801:Humans; D007117:Immunization, Secondary; D007073:Immunoglobulin E / Q000032:analysis; D007252:Influenza Vaccines / Q000009:adverse effects* / Q000276:immunology; D007277:Injections, Jet; D011897:Random Allocation; D012426:Russia; D013997:Time Factors; D014505:Urban Population; D015164:Vaccines, Inactivated / Q000009:adverse effects / Q000276:immunology
D007252:Influenza Vaccines; D015164:Vaccines, Inactivated; D007073:Immunoglobulin E
Kharakteristika klinicheskoĭ i immunologicheskoĭ bezvrednosti grippoznykh inaktivirovannykh vaktsin dlia deteĭ v usloviiakh mnogokratnoĭ immunizatsii.