title: Erythromycin 2 percent gel in the treatment of acne vulgaris.
abstract: A gel formulation of erythromycin 2 percent was compared with its vehicle in a double-blind multicenter study involving patients with mild to moderate acne vulgaris. In an analysis of 187 patients treated twice daily for 8 weeks, erythromycin 2 percent gel proved to be significantly more effective than vehicle in reducing the numbers of both inflammatory and noninflammatory lesions. After 8 weeks, 60 percent of erythromycin-treated patients had good or excellent responses compared with 36 percent of those using vehicle (p = 0.001); the lesions in two patients using erythromycin were completely cleared. The majority of patients had a favorable impression of the cosmetic characteristics of the gel formulation.
authors.affiliation: Department of Dermatology, Boston University Medical Center, Massachusetts.
authors.forename: P E
authors.initials: PE
authors.lastname: Pochi
authors.forename: F K
authors.initials: FK
authors.lastname: Bagatell
authors.forename: C N
authors.initials: CN
authors.lastname: Ellis
authors.forename: R B
authors.initials: RB
authors.lastname: Stoughton
authors.forename: C G
authors.initials: CG
authors.lastname: Whitmore
authors.forename: G D
authors.initials: GD
authors.lastname: Saatjian
authors.forename: J
authors.initials: J
authors.lastname: Sefton
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D003258:Consumer Behavior; D004917:Erythromycin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005148:Facial Dermatoses / Q000188:drug therapy; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005782:Gels; D004917:Erythromycin