title: Comparison of the mitochondrial endonucleases from Neurospora crassa and Saccharomyces cerevisiae.
abstract: The endonucleases from Neurospora crassa and Saccharomyces cerevisiae are not closely related antigenically. They also differ with respect to their activity at pH 8, their degree of hydrophobicity, and their sensitivity to elevated temperatures. However, the two nucleases have similar specific activities, are inhibited by EDTA, and have nearly identical substrate specificities. Since the enzymes also have the same mode of action and intracellular location, these similarities may indicate that they have the same physiological role despite their structural differences.
authors.forename: R G
authors.initials: RG
authors.lastname: von Tigerstrom
authors.forename: S
authors.initials: S
authors.lastname: Stelmaschuk
mesh_terms: D003429:Cross Reactions; D004355:Drug Stability; D004720:Endonucleases / Q000276:immunology / Q000378:metabolism; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000494:pharmacology; D008928:Mitochondria / Q000201:enzymology; D009491:Neurospora / Q000201:enzymology*; D009492:Neurospora crassa / Q000201:enzymology* / Q000276:immunology; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000276:immunology; D013045:Species Specificity; D013379:Substrate Specificity
chemical_list: D004720:Endonucleases; D008274:Magnesium