Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide.
Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. It is concluded that a structural homology exists between the two viruses, despite minimal primary sequence conservation.
Emini
E A
EA
Hughes
J V
JV
Perlow
D S
DS
Boger
J
J
D000595:Amino Acid Sequence; D006508:Hepatitis Antibodies / Q000096:biosynthesis*; D006507:Hepatovirus / Q000235:genetics* / Q000276:immunology; D009500:Neutralization Tests; D017955:Poliovirus / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics*; D015678:Viral Structural Proteins
D006508:Hepatitis Antibodies; D014764:Viral Proteins; D015678:Viral Structural Proteins