Effect of vasopressin on atrial natriuretic peptide release and renal function in dogs.
To assess the effect of arginine vasopressin (AVP) and 1-deamino-8-D-AVP (DDAVP) on atrial natriuretic peptide (ANP) release, renal water and electrolyte excretion, and cardiovascular function, AVP and DDAVP were administered at a dose of 10 ng.kg-1.min-1 iv for 30 min into anesthetized dogs receiving saline infusion at a rate of 1 ml.kg-1.min-1 (n = 12). In the control study, saline was infused alone (n = 6). AVP potentiated the plasma ANP response to an increase in plasma volume produced by saline infusion, increased mean arterial blood pressure (MAP), and exaggerated the natriuresis and kaliuresis. DDAVP did not potentiate the increase in plasma ANP but enhanced the natriuresis without any rise in MAP. Saline alone increased plasma ANP as well as sodium and potassium excretion with no changes in MAP. Inulin and p-aminohippuric acid clearances did not change during these studies. The results suggest that in hydrated dogs, AVP may increase ANP release and arterial blood pressure via the vasopressor activity of AVP and potentiate the natriuresis and kaliuresis, but the increased ANP may play little role in the natriuresis.
Inoue
M
M
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Kimura
T
T
Ota
K
K
Iitake
K
K
Shoji
M
M
Sato
K
K
Ota
M
M
Yoshinaga
K
K
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D009318:Natriuresis / Q000187:drug effects; D009994:Osmolar Concentration; D010953:Plasma Volume / Q000187:drug effects; D011188:Potassium / Q000652:urine; D012016:Reference Values; D012964:Sodium / Q000652:urine; D014556:Urine
D001798:Blood Proteins; D001127:Arginine Vasopressin; D009320:Atrial Natriuretic Factor; D012964:Sodium; D003894:Deamino Arginine Vasopressin; D011188:Potassium