title: Indium-111 chloride for detecting suspected hepatomas in patients with focal defects on technetium-99m sulfur colloid liver imaging.
abstract: Twenty-three patients with hepatic cirrhosis and focal defects on Tc-99m sulfur colloid (SC) scintigrams were restudied with In-111 chloride to determine if indium localization in the focal defect is indicative of a hepatoma. Seven of eight patients with proven hepatomas had positive studies; however, six of 15 patients without hepatomas also had studies interpreted as positive. Thus, In-111 chloride is highly sensitive for the detection of hepatomas, and a negative indium study would militate against this diagnosis. The high false-positive rate found may be due to technical factors rather than a lack of specificity of localization; the experience of others seems to support this impression. At present, In-111 chloride scintigraphy for focal hepatic defects appears to be useful in ruling out hepatoma.
authors.forename: H D
authors.initials: HD
authors.lastname: Fawcett
authors.forename: B A
authors.initials: BA
authors.lastname: Sayle
authors.forename: M Z
authors.initials: MZ
authors.lastname: Winsett
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging*; D005189:False Positive Reactions; D006801:Humans; D007204:Indium; D008099:Liver / Q000000981:diagnostic imaging; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D011868:Radioisotopes; D007204:Indium; C020758:indium trichloride; D013671:Technetium Tc 99m Sulfur Colloid