[Effects of lead poisoning on properties of brain mitochondria in young rats].
When the litters were 14 days old, wistar rat pups received lead ions. The suckling mother was fed by a powdered laboratory chow containing lead carbonate (1%, 2%, 4%). The intoxication was going on for 3 days to 9 weeks. While lead-fed pups showed a decrease in body-weight gain and in neurologic development, lead ions were without effects on oxygen consumption, ADP-phosphorylation and activity of several enzymes of cerebral mitochondria. On the other hand, the important lead accumulation into cerebral mitochondria was in a straight ratio with lead doses in the feedings. To explain the in vivo data, the effects of lead acetate were investigated in vitro on brain mitochondria of young male wistar rats. Our findings indicate that lead ions alter mitochondrial respiration and ADP-phosphorylation and that inorganic phosphate has a protective effect.
Dumas
P
P
Gueldry
D
D
Loireau
A
A
Chomard
P
P
Buthieau
A M
AM
Autissier
N
N
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D007854:Lead / Q000032:analysis / Q000494:pharmacology; D007855:Lead Poisoning / Q000150:complications*; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D009245:NADH Dehydrogenase / Q000378:metabolism; D009942:Organometallic Compounds; D010101:Oxygen Consumption / Q000187:drug effects; D010758:Phosphorus / Q000494:pharmacology / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013997:Time Factors
D009942:Organometallic Compounds; D010758:Phosphorus; D007854:Lead; D013385:Succinate Dehydrogenase; D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV; C008261:lead acetate
Effets de l'intoxication par le plomb sur les propriétés des mitochondries de cerveau de jeune rat.