[Cytogenetic effect of gamma quanta and secondary radiation generated by 70 GeV protons on Chinese hamster fibroblasts].
The study of the cytogenetic effects (for instance, the chromosome aberration frequency in G2 cells and micronucleus formation) after exposure of Chinese hamster cells to gamma-rays and secondary radiation generated by 70 GeV protons showed that the relative biological effectiveness (RBE) of secondary radiation was approximately 3. The contribution of isochromatid deletions and exchanges into the total spectrum of rearrangements induced by the secondary radiation was different from that observed on gamma-irradiation. The absence of the modifying effect of caffeine on the cells exposed to the secondary radiation indicated that RBE of the secondary radiation from 70 GeV protons was mainly associated with its inhibitory action on the cytogenetic damages repair.
Akhmadieva
A Kh
AKh
Aptikaeva
G F
GF
Livanova
I A
IA
Antipov
A V
AV
Smirnova
E N
EN
D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D002478:Cells, Cultured; D002842:Chromatids / Q000187:drug effects / Q000528:radiation effects; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D004338:Drug Combinations / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D010315:Particle Accelerators; D011522:Protons
D001565:Benzoates; D004338:Drug Combinations; D011522:Protons; D002110:Caffeine; C025741:caffeine, sodium benzoate drug combination
Tsitogeneticheskoe deĭstvie gamma-kvantov i vtorichnogo izlucheniia, generiruemogo protonami s énergieĭ 70 GéV, na fibroblasty kitaĭskogo khomiachka.