title: Mapping DNA sequences in a human X-chromosome deletion which extends across the region of the Duchenne muscular dystrophy mutation.
abstract: A somatic cell hybrid has been constructed and characterized using fibroblasts from a phenotypically normal woman who possesses an X chromosome with an interstitial deletion of the short arm. High-resolution banding indicates that the deleted segment is either Xp22.13-p11.4 or Xp22.11-p11.23. Southern blot hybridization to previously mapped DNA sequences confirms that the missing segment of the X chromosome is a deletion and not an interstitial translocation and supports the cytogenetic interpretation that the deletion extends proximal of Xp11.3 and therefore probably comprises Xp22.11-p11.23. Three further DNA sequences have been localized to the region of the deleted segment. The following order has been assigned to the seven probes used: Xpter-RC8-pXUT22-(OA1,C7,M2C)-L1.28-RD6 -Xcen.
authors.forename: C
authors.initials: C
authors.lastname: Ingle
authors.forename: R
authors.initials: R
authors.lastname: Williamson
authors.forename: A
authors.initials: A
authors.lastname: de la Chapelle
authors.forename: R R
authors.initials: RR
authors.lastname: Herva
authors.forename: K
authors.initials: K
authors.lastname: Haapala
authors.forename: G
authors.initials: G
authors.lastname: Bates
authors.forename: H F
authors.initials: HF
authors.lastname: Willard
authors.forename: P
authors.initials: P
authors.lastname: Pearson
authors.forename: K E
authors.initials: KE
authors.lastname: Davies
mesh_terms: D000818:Animals; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D007621:Karyotyping; D009136:Muscular Dystrophies / Q000235:genetics*; D009154:Mutation; D014960:X Chromosome
chemical_list: D005819:Genetic Markers; D004247:DNA; D004262:DNA Restriction Enzymes