[Antibiotic therapy protocol using ceftazidime 3g/day alone or in combination with vancomycin or amikacin. In febrile episodes in neutropenic patients].
In a preliminary study of 21 febrile episodes in neutropenic patients ceftazidime used as empirical treatment in doses of 3 grams per day succeeded in controlling fever in 74 per cent of the cases. Laboratory studies performed in patients with Gram-negative septicaemia showed clinically effective plasma concentrations of the antibiotic. A trial of ceftazidime (3 g/day) administered alone or combined with amikacin or vancomycin is currently in progress in two medical centres. No statistically significant conclusions could be reached from an intermediate study.
Marie
J P
JP
Service d'Hématologie, Institut Gustave Roussy, Villejuif.
Pico
J L
JL
Chiche
D
D
Fitoussi
F
F
Delmer
A
A
Baume
D
D
Rio
B
B
Ajchenbaum
F
F
Richet
H
H
Tancrède
C
C
D000380:Agranulocytosis / Q000150:complications*; D000583:Amikacin / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D002442:Ceftazidime / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D009503:Neutropenia / Q000150:complications*; D011897:Random Allocation; D014640:Vancomycin / Q000627:therapeutic use*
D014640:Vancomycin; D000583:Amikacin; D002442:Ceftazidime
Protocole d'antibiothérapie utilisant la ceftazidime à la dose de 3 g/jour seule ou en association avec la vancomycine ou l'amikacine. Lors des épisodes fébriles chez le neutropénique.