title: [Prophylactic efficacy of reaferon in viral hepatitis A and acute respiratory infections in children].
abstract: Reaferon, the analog of human alpha 2-interferon obtained by gene engineering techniques, was studied with a view to its use for the prevention of hepatitis A. The study involved children of preschool age in Tashkent. In a strictly controlled trial children aged 2-6 years received the preparation orally in a dose of 1 X 10(6) I. U. or the diluent alone used as placebo. The preparation was administered to 1,100 children and the placebo to 1,078 children. The preparation and placebo were administered twice a week for two months. On the whole, during that period hepatitis A morbidity in both test and control groups of children was the same (5.1% and 4.9% respectively), but among children of nursery age receiving Reaferon the incidence of hepatitis A and acute respiratory viral infections was lower than among those receiving the placebo, though this difference was statistically significant only for cases of acute respiratory infections.
authors.forename: A K
authors.initials: AK
authors.lastname: Iuldashev
authors.forename: A N
authors.initials: AN
authors.lastname: Slepushkin
authors.forename: M A
authors.initials: MA
authors.lastname: Khodzhaeva
authors.forename: E I
authors.initials: EI
authors.lastname: Schastnyĭ
authors.forename: F Kh
authors.initials: FKh
authors.lastname: Kamilov
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D004341:Drug Evaluation; D006506:Hepatitis A / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D007370:Interferon Type I / Q000627:therapeutic use; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D010919:Placebos; D011994:Recombinant Proteins / Q000627:therapeutic use*; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000517:prevention & control*; D012621:Seasons; D013997:Time Factors; D014610:Uzbekistan
chemical_list: D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D010919:Placebos; D011994:Recombinant Proteins
vernacular_title: Izuchenie profilakticheskoĭ éffektivnosti reaferona pri virusnom gepatite A i ostrykh respiratornykh infektsiiakh u deteĭ.