title: Acidic fibroblast growth factor stimulates opsin levels in retinal photoreceptor cells in vitro.
abstract: It is demonstrated that newborn rat retinal photoreceptor cells can differentiate in monolayer culture, and synthesize de novo photoreceptor-specific proteins such as opsin. When maintained in serum supplemented medium on a laminin substrate, these cells survive for up to 3 weeks. The addition of acidic fibroblast growth factor stimulates an increase in the levels of opsin of 5-10-fold control values, and prolongs cell survival by up to 6 days.
authors.affiliation: Unité de Recherches Gérontologiques, INSERM U118-CNRS U A630, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Hicks
authors.forename: Y
authors.initials: Y
authors.lastname: Courtois
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005136:Eye Proteins / Q000378:metabolism*; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D007700:Kinetics; D010786:Photoreceptor Cells / Q000187:drug effects / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D012168:Retinal Pigments / Q000378:metabolism*; D017299:Rod Opsins
chemical_list: D005136:Eye Proteins; D012168:Retinal Pigments; D017299:Rod Opsins; D005346:Fibroblast Growth Factors