Sodium-potassium-ATPase activity in the dorsal root ganglia of rats with streptozotocin-induced diabetes.
Sodium-potassium-ATPase activity was measured in excised dorsal root ganglia of streptozotocin-diabetic rats, 2 months after induction of diabetes. In comparison with age-matched controls, there was a decrease in both the total and ouabain-insensitive activity, indicating an overall reduction in ouabain-sensitive activity of 46%. This decrease may explain the reduced amino-acid uptake exhibited by diabetic sensory ganglia and could be relevant to the development of diabetic neuropathy.
Green
R J
RJ
King
R H
RH
Thomas
P K
PK
Baron
D N
DN
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D005727:Ganglia, Spinal / Q000201:enzymology*; D008297:Male; D010042:Ouabain / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase