[A technic for selection of antidotes to an acute lethal poisoning].
The dose of a toxic substance which is lethal to the rat within 15 min (LD100.15 min) and its specific antidotes are defined. Atropine, diazepam and nimodipine in sequential administration are effective antidotes to a LD100.15 min (1.5 mg/kg) of paraoxon, an anticholinesterase.
Trouvé
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Laboratoire de Toxicologie cellulaire, INSERM, Hôpital Fernand-Widal, Saint-Denis, Paris.
Nahas
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D000818:Animals; D000931:Antidotes; D001285:Atropine / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D008297:Male; D009553:Nimodipine / Q000627:therapeutic use; D010261:Paraoxon / Q000506:poisoning*; D051381:Rats
D000931:Antidotes; D009553:Nimodipine; D001285:Atropine; D003975:Diazepam; D010261:Paraoxon
Une technique pour la sélection d'antidotes à une intoxication létale aiguë.