title: Fused transcript of abl and bcr genes in chronic myelogenous leukaemia.
abstract: Human chronic myelogenous leukaemia is characterized by a reciprocal translocation between chromosomes 9 and 22 resulting in an abbreviated form of chromosome 22 and the transfer of the abl cellular oncogene from chromosome 9 into the bcr gene of chromosome 22. Characterization of an 8-kilobase RNA specific to chronic myelogenous leukaemia shows it to be a fused transcript of the two genes. The fused protein that would be produced is probably involved in the malignant process.
authors.forename: E
authors.initials: E
authors.lastname: Shtivelman
authors.forename: B
authors.initials: B
authors.lastname: Lifshitz
authors.forename: R P
authors.initials: RP
authors.lastname: Gale
authors.forename: E
authors.initials: E
authors.lastname: Canaani
mesh_terms: D001483:Base Sequence; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D014158:Transcription, Genetic
chemical_list: D004273:DNA, Neoplasm; D004262:DNA Restriction Enzymes