Parathion-provoked lethality in rats is reduced by diethyldithiocarbamate.
Intoxication of male rats with 5 mg/kg parathion reduces survival to 15%. Diethyldithiocarbamate (DDC), known to inhibit mixed-function oxidase activity, has no effect on survival rate when this compound is used in a dosage of 300 mg/kg 45 min before or 10 min after parathion intoxication. However, when DDC and parathion are administered simultaneously, the rate of survival rises to 53%.
Homann
J
J
Schneider
S
S
Matthes
K J
KJ
D000818:Animals; D004050:Ditiocarb / Q000494:pharmacology*; D007928:Lethal Dose 50; D008297:Male; D010278:Parathion / Q000037:antagonists & inhibitors / Q000633:toxicity*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013859:Thiocarbamates / Q000494:pharmacology*
D013859:Thiocarbamates; D010278:Parathion; D004050:Ditiocarb; D010634:Phenobarbital