title: Auditory P300 response in the assessment of Alzheimer's disease in Down's syndrome: a 2-year follow-up study.
abstract: Sixty-five subjects with Down's syndrome were followed up and retested 2 years after the initial recording of auditory P300 (P3) event-related potential described in a companion paper (Blackwood et al., 1988). The number of subjects showing clinical evidence for Alzheimer's type dementia had increased by a further 14%. In subjects showing clinical deterioration over a period of 2 years, 78% (7/9) had an increase in P3 latency which was three standard deviations or greater than the group mean. None of the 20 fragile-X group retested showed significant change after 2 years. The results suggest that P3 change may be a sensitive index of the onset of Alzheimer's type dementia in Down's syndrome.
authors.affiliation: University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, Scotland.
authors.forename: W J
authors.initials: WJ
authors.lastname: Muir
authors.forename: I
authors.initials: I
authors.lastname: Squire
authors.forename: D H
authors.initials: DH
authors.lastname: Blackwood
authors.forename: M D
authors.initials: MD
authors.lastname: Speight
authors.forename: D M
authors.initials: DM
authors.lastname: St Clair
authors.forename: C
authors.initials: C
authors.lastname: Oliver
authors.forename: P
authors.initials: P
authors.lastname: Dickens
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology; D004314:Down Syndrome / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory; D005260:Female; D005500:Follow-Up Studies; D005600:Fragile X Syndrome / Q000503:physiopathology; D006801:Humans; D008607:Intellectual Disability / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D012815:Signal Processing, Computer-Assisted