title: Genome RNAS of virulent and attenuated strains of bluetongue virus serotypes 10, 11, 13 and 17.
abstract: An improved system was developed for the electrophoretic resolution of bluetongue virus (BTV) genome segments. This procedure was used to compare the genome segments of wild type (W) and vaccine (V) strains of BTV serotypes 10, 11, 13 and 17. Numerous alterations in the migration of individual genome segments could be detected between W and V strains of each serotype, suggesting that many mutations had occurred during attenuation of the V strains. In addition, electrophoretic polymorphisms not previously detected, were found between W strains of the 4 serotypes.
authors.forename: R F
authors.initials: RF
authors.lastname: Ramig
authors.forename: S K
authors.initials: SK
authors.lastname: Samal
authors.forename: S
authors.initials: S
authors.lastname: McConnell
mesh_terms: D001820:Bluetongue virus / Q000145:classification / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity; D008970:Molecular Weight; D012330:RNA, Double-Stranded / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics*; D012087:Reoviridae / Q000235:genetics*; D012703:Serotyping; D014613:Vaccines, Attenuated / Q000032:analysis; D014765:Viral Vaccines / Q000032:analysis
chemical_list: D012330:RNA, Double-Stranded; D012367:RNA, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines