title: Are there genetic determinants for the glucose intolerance of acromegaly?
abstract: A genetic marker identifying the two parental insulin genes has been studied in 51 Caucasian acromegalics by Southern blot hybridization techniques using a cloned insulin gene probe. Two main DNA insertion classes were detected corresponding to the class 1 and class 3 alleles and thus the following genotypes were found: 1/1, 1/3 and 3/3. The acromegalics were subdivided depending on whether they had a normal (n = 30) or abnormal (n = 21) response to a 50 gm oral glucose tolerance test before treatment. The phenotype frequencies in the former group were 1/1, 43%; 1/3, 53%; and 3/3, 4%; and in the latter group the corresponding figures were 76%, 24% and 0%. The relative incidence of concordance of the phenotype 1/1 with abnormal glucose tolerance in acromegaly was 4.2. This phenotype is also associated with insulin dependent (Type 1) diabetes mellitus.
authors.forename: G A
authors.initials: GA
authors.lastname: Hitman
authors.forename: J
authors.initials: J
authors.lastname: Katz
authors.forename: N
authors.initials: N
authors.lastname: Lytras
authors.forename: N I
authors.initials: NI
authors.lastname: Jowett
authors.forename: J A
authors.initials: JA
authors.lastname: Wass
authors.forename: G M
authors.initials: GM
authors.lastname: Besser
authors.forename: D J
authors.initials: DJ
authors.lastname: Galton
mesh_terms: D000172:Acromegaly / Q000235:genetics* / Q000378:metabolism; D004251:DNA Transposable Elements; D005260:Female; D005819:Genetic Markers; D005947:Glucose / Q000235:genetics / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype
chemical_list: D004251:DNA Transposable Elements; D005819:Genetic Markers; D007328:Insulin; D005947:Glucose