title: Severe clinical disease induced in cattle persistently infected with noncytopathic bovine viral diarrhea virus by superinfection with cytopathic bovine viral diarrhea virus.
abstract: Eight healthy cattle that were persistently infected with noncytopathic bovine viral diarrhea virus (BVDV) were inoculated with cell culture fluids that contained noncytopathic or cytopathic BVDV. A severe disease occurred after inoculation with cytopathic BVDV. The clinical signs, lesions, and immune response were consistent with those of clinical BVDV infections.
authors.forename: S R
authors.initials: SR
authors.lastname: Bolin
authors.forename: A W
authors.initials: AW
authors.lastname: McClurkin
authors.forename: R C
authors.initials: RC
authors.lastname: Cutlip
authors.forename: M F
authors.initials: MF
authors.lastname: Coria
mesh_terms: D000818:Animals; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology*; D002417:Cattle; D002418:Cattle Diseases / Q000503:physiopathology*; D001908:Diarrhea Viruses, Bovine Viral / Q000472:pathogenicity*; D004064:Digestive System / Q000473:pathology; D005260:Female; D008297:Male; D010576:Pestivirus / Q000472:pathogenicity*; D014774:Virulence