title: In vitro and in vivo evaluation of latex condoms using a two-phase nonoxynol 9 system.
abstract: In vitro studies were carried out that indicated that a lubricant system consisting of 0.45 +/- 0.1 ml of silicon fluid containing 6.6% +/- 0.5% by volume of nonoxynol 9 and a spermicidal cream consisting of 0.45 +/- 0.1 ml made up of 63.4% polyethylene glycol 400 and 30.0% polyethylene glycol 3350 containing 6.6% +/- 0.5% nonoxynol 9 was effective in reducing sperm motility and viability. This system was tested in vivo with the use of simulated rupture techniques and was found to be equally as effective. Double-blind preference studies were carried out in vivo which showed that the condom system is convenient and comfortable to use, nonirritating to the vagina or urethral mucosa, and esthetically pleasing to the young, reproductive-age population.
authors.forename: N
authors.initials: N
authors.lastname: Rodgers-Neame
authors.forename: S F
authors.initials: SF
authors.lastname: Duncan
authors.forename: E L
authors.initials: EL
authors.lastname: Bradley
authors.forename: R E
authors.initials: RE
authors.lastname: Blackwell
mesh_terms: D000328:Adult; D003258:Consumer Behavior; D003272:Contraceptive Agents, Male / Q000627:therapeutic use*; D003275:Contraceptive Devices, Male; D005260:Female; D006801:Humans; D008153:Lubrication; D008297:Male; D017137:Nonoxynol; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D013081:Sperm Motility / Q000187:drug effects; D013083:Sperm Transport / Q000187:drug effects; D013089:Spermatocidal Agents; D013997:Time Factors
chemical_list: D003272:Contraceptive Agents, Male; D013089:Spermatocidal Agents; D017137:Nonoxynol; D011092:Polyethylene Glycols