Binding characteristics of epidermal growth factor receptors in male and female rat liver cell membrane preparations.
The binding characteristics of epidermal growth factor (EGF) receptors were studied in cell membrane preparations from adult male (n = 14) and female (n = 13) rat livers. Results indicate a significant lower (about 65%) number of EGF receptors in female preparations. The possibility that the decrease in EGF receptors was only a reflection of an excess free EGF in female preparations was ruled out by means of acid extraction, ultrafiltration, and measurement of EGF in the acid extracts. In view of the known role of EGF in cell differentiation, it may be important to recognize that the number of its receptors, at least in liver preparations, is markedly different between sexes.
Benveniste
R
R
Carson
S A
SA
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002474:Cell-Free System; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors; D005260:Female; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012737:Sex Factors
D011956:Receptors, Cell Surface; D004815:Epidermal Growth Factor; D066246:ErbB Receptors