title: Inhibition of lipid peroxidation by heme-nonapeptide derived from cytochrome c.
abstract: Heme-nonapeptide, derived from cytochrome c, inhibited both the NADPH- and NADH-dependent lipid peroxidation of brain microsomes but, in the case of liver microsomes, this inhibitory effect manifested itself in the presence of SKF-525A (a specific blocker of cytochrome P-450) only. Heme-nonapeptide prevented the transient accumulation of lipid peroxides in microsomes during lipid peroxidation. The oxygen consumption of microsomes in the presence of NADPH or NADH was stimulated by heme-nonapeptide. From these results we concluded that, in vitro, there are two independent mechanisms of lipid peroxidation in liver microsomes. It is suggested that, in vivo, the heme-peptide-sensitive mechanism, observed in brain microsomes, is more important.
authors.forename: L
authors.initials: L
authors.lastname: Vodnyánszky
authors.forename: A
authors.initials: A
authors.lastname: Marton
authors.forename: I
authors.initials: I
authors.lastname: Venekei
authors.forename: M
authors.initials: M
authors.lastname: Végh
authors.forename: A
authors.initials: A
authors.lastname: Blázovits
authors.forename: A
authors.initials: A
authors.lastname: Kittel
authors.forename: I
authors.initials: I
authors.lastname: Horváth
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D003574:Cytochrome c Group / Q000378:metabolism* / Q000494:pharmacology; D045304:Cytochromes c; D006418:Heme / Q000378:metabolism* / Q000494:pharmacology; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism*; D008861:Microsomes / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010101:Oxygen Consumption; D010446:Peptide Fragments / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003574:Cytochrome c Group; D008054:Lipid Peroxides; D010446:Peptide Fragments; C046027:heme nonapeptide; D009243:NAD; D006418:Heme; D009249:NADP; D045304:Cytochromes c