title: Evaluation of in vitro activity of teicoplanin against recent clinical isolates.
abstract: The in vitro antibacterial activity of teicoplanin, a new glycopeptide antibiotic, previously named teichomycin A2, has been compared to that of five other chemoantibiotics: netilmicin, clindamycin, rifampicin, enoxacin and vancomycin. The minimum inhibitory concentration (MIC) values against 588 gram-positive strains, 561 facultative aerobes and 27 anaerobes, recently isolated from clinical specimens, were evaluated. Teicoplanin showed the highest activity against all the tested strains, with a geometrical mean of the MICs (GMM), a MIC50 and MIC90 of 0.123, 0.12 and 0.5 micrograms/ml respectively.
authors.affiliation: Department of Cellular and Molecular Biology and Pathology, II Medical School, University of Naples, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Nani
authors.forename: G
authors.initials: G
authors.lastname: Amato
authors.forename: D
authors.initials: D
authors.lastname: Anzivino
authors.forename: B
authors.initials: B
authors.lastname: Covelli
authors.forename: M
authors.initials: M
authors.lastname: Lembo
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects; D006020:Glycopeptides / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D017334:Teicoplanin
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D017334:Teicoplanin