title: Effect of a single dose of mesoglycan on the human fibrinolytic system, and the profibrinolytic action of nine daily doses.
abstract: The profibrinolytic activity of orally administered Mesoglycan was evaluated in 18 patients affected by impaired plasma fibrinolytic activity. Mesoglycan was administered by a single oral dose of 24, 48 or 72 mg on 1 day, and by repeated doses of 48 mg twice a day for 9 consecutive days. After the single administration all the fibrinolytic parameters were significantly and positively influenced with an order of magnitude and a duration of effects proportional to the dose employed. After the repeated administration, a constant and reproducible activation of the fibrinolytic system was observed without any interference with haemocoagulative parameters. These results confirm that Mesoglycan is endowed with a relevant profibrinolytic activity in man after oral administration. The pharmacological activity of Mesoglycan could possibly involve the liberation of a certain amount of plasminogen tissue activator.
authors.affiliation: Istituto di Patologia Speciale Medica, University of Siena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Vittoria
authors.forename: G L
authors.initials: GL
authors.lastname: Messa
authors.forename: C
authors.initials: C
authors.lastname: Frigerio
authors.forename: G
authors.initials: G
authors.lastname: Celasco
authors.forename: A
authors.initials: A
authors.lastname: Auteri
mesh_terms: D000284:Administration, Oral; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male
chemical_list: D006025:Glycosaminoglycans; C040617:mesoglycan