Induction of sister-chromatid exchanges by restriction endonucleases.
Restriction endonucleases Cfo 1, Pvu II, Sma I, Hpa II, Taq I and Hae III were tested for their ability to induce SCEs in CHO cells. The results indicate that the DNA double-strand breaks induced during S-phase by these enzymes lead to an increase in the frequencies of SCEs.
Natarajan
A T
AT
Mullenders
L H
LH
Meijers
M
M
Mukherjee
U
U
D000818:Animals; D002460:Cell Line; D002875:Chromosomes / Q000187:drug effects / Q000648:ultrastructure; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000378:metabolism; D004262:DNA Restriction Enzymes / Q000494:pharmacology*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000648:ultrastructure; D010053:Ovary; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D004247:DNA; D004262:DNA Restriction Enzymes