Observations on the chemical and physiological properties of urodiolenone, an urinary compound found in hypertension.
Urodiolenone is a substance that appears as the glucuronide in the urine of 1 in 3 hypertensive subjects. It is a potent inhibitor of Na+, K+-ATPase in kidney tissue of the guinea pig, as measured by cytochemical assay. Chemical and mass spectrometric evidence is presented, from which it is concluded that urodiolenone is a sesquiterpenoid substance, is a bicyclic enone with a vicinal diol side chain, and has molecular formula C15H24O3.
Neufeld
E
E
Sklarz
B
B
Goldberg
S
S
Gilad
S
S
Goldfarb
H
H
Laurian
L
L
Silverberg
D S
DS
Chayen
R
R
D005260:Female; D006801:Humans; D006973:Hypertension / Q000652:urine*; D008297:Male; D013058:Mass Spectrometry; D012717:Sesquiterpenes / Q000494:pharmacology / Q000652:urine*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
D012717:Sesquiterpenes; C044615:urodiolenone; D000254:Sodium-Potassium-Exchanging ATPase