title: Receptor interactions in stimulation of hydrolysis of inositol phospholipids.
abstract: The amount of carbachol-induced hydrolysis of inositol phospholipid in the mouse exocrine pancreas is reduced when cholecystokinin octapeptide, an agonist which works through a separate class of receptors, is also present. This effect does not appear to be due to depletion of inositol phospholipid from the cell membranes. These results indicate that the hydrolysis of inositol phospholipid is not always dependent on the number of receptors occupied and that the different classes of receptors share at least one component in the response system.
authors.forename: M L
authors.initials: ML
authors.lastname: Roberts
authors.forename: K A
authors.initials: KA
authors.lastname: Tennes
mesh_terms: D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D006868:Hydrolysis; D066298:In Vitro Techniques; D051379:Mice; D010179:Pancreas / Q000378:metabolism; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000502:physiology*; D012844:Sincalide / Q000494:pharmacology
chemical_list: D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols; D011956:Receptors, Cell Surface; D002217:Carbachol; D012844:Sincalide