Histamine may act through cyclic AMP on hippocampal neurones.
Bath applied histamine and 8-bromo-cyclic AMP and intracellularly injected cyclic AMP block-long-lasting after-hyperpolarizations and the accommodation of firing in CA1 pyramidal cells recorded in rat hippocampal slices. This action is due to reduction of a calcium-activated potassium conductance (gK(Ca] and leads to potentiation of excitatory signals including epileptiform discharges. The effects are further potentiated and prolonged by a phosphodiesterase inhibitor (Ro 20-1724).
Haas
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HL
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000502:physiology*; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D006632:Histamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D013779:Tetrodotoxin / Q000494:pharmacology
D015124:8-Bromo Cyclic Adenosine Monophosphate; D013779:Tetrodotoxin; D006632:Histamine; D000242:Cyclic AMP