Effect of captopril on blood pressure and renal function in patients with transplant renal artery stenosis.
We evaluated 9 patients with transplant renal artery stenosis. Captopril treatment always resulted in a dramatic decrease in renal function. Moreover, only in patients (n = 2) with a stenosis in one out of more renal arteries a satisfying fall in blood pressure was achieved. Surgical reconstruction of the stenosis was successful in 4 out of 5 patients. Angiotensin I-converting enzyme inhibition in transplant renal artery stenosis often leads to loss of graft function, probably due to efferent vasodilation.
van der Woude
F J
FJ
van Son
W J
WJ
Tegzess
A M
AM
Donker
A J
AJ
Slooff
M J
MJ
van der Slikke
L B
LB
Hoorntje
S J
SJ
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006978:Hypertension, Renovascular / Q000188:drug therapy* / Q000209:etiology; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D016030:Kidney Transplantation; D008297:Male; D011392:Proline / Q000031:analogs & derivatives*; D012078:Renal Artery Obstruction / Q000150:complications* / Q000601:surgery
D000806:Angiotensin-Converting Enzyme Inhibitors; D011392:Proline; D002216:Captopril