Synthesis of N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline (lisinopril).
The synthesis and some of the spectral properties of N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline (lisinopril, MK-521) are described. This compound inhibits angiotensin-converting enzyme with an IC50 of 1.2 X 10(-9) M.
Wu
M T
MT
Douglas
A W
AW
Ondeyka
D L
DL
Payne
L G
LG
Ikeler
T J
TJ
Joshua
H
H
Patchett
A A
AA
D002247:Carbon Isotopes; D055598:Chemical Phenomena; D002621:Chemistry; D004151:Dipeptides / Q000138:chemical synthesis*; D017706:Lisinopril; D009682:Magnetic Resonance Spectroscopy
D002247:Carbon Isotopes; D004151:Dipeptides; D017706:Lisinopril