Reversible abnormalities of the Hering Breuer reflex in acrylamide neuropathy.
The sensitivity of the Hering Breuer reflex was compared in anaesthetised rabbits before, during and after the induction of acrylamide neuropathy, and was measured as the tracheal pressure which produced 30 seconds of apnoea. After four weeks of acrylamide (400 mg/kg total dose) there was ataxia and the conduction velocity of hindlimb motor nerves was significantly reduced. At this time there was a marked and reproducible reduction in the sensitivity of the Hering Breuer reflex. The ataxia resolved within a month of stopping acrylamide administration. Three months after the cessation of acrylamide the sensitivity of the Hering Breuer reflex had increased significantly but had not returned to normal.
Satchell
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D020106:Acrylamide; D000178:Acrylamides / Q000494:pharmacology*; D000818:Animals; D003964:Diaphragm / Q000294:innervation; D004576:Electromyography; D008168:Lung / Q000294:innervation; D008465:Mechanoreceptors / Q000187:drug effects*; D009046:Motor Neurons / Q000187:drug effects; D009413:Nerve Fibers, Myelinated / Q000187:drug effects*; D009422:Nervous System Diseases / Q000139:chemically induced*; D009431:Neural Conduction / Q000187:drug effects; D010525:Peripheral Nerves / Q000187:drug effects; D011661:Pulmonary Stretch Receptors / Q000187:drug effects*; D011817:Rabbits; D012018:Reflex / Q000187:drug effects*; D012119:Respiration / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*; D014630:Vagus Nerve / Q000187:drug effects
D000178:Acrylamides; D020106:Acrylamide