title: Atrial natriuretic factor in renal failure and posthemodialytic postural hypotension.
abstract: Atrial natriuretic factor (ANF) levels were ten times normal in hemodialysis patients before dialysis. ANF was not cleared by the dialyzer membrane but plasma levels decreased 47% by the end of dialysis. Patients undergoing peritoneal dialysis had plasma ANF levels four times normal and had detectable ANF in their dialysate. Hemodialysis patients with a marked fall in BP after dialysis had higher ANF levels (P less than 0.05) and lower norepinephrine (NE) levels (P less than 0.05) associated with a failure to increase NE in response to dialysis. Elevated ANF levels are associated with postdialysis hypotension in hemodialysis patients.
authors.affiliation: Department of Medicine, University of California-San Diego Medical Center.
authors.forename: E C
authors.initials: EC
authors.lastname: Morrissey
authors.forename: K D
authors.initials: KD
authors.lastname: Wilner
authors.forename: R R
authors.initials: RR
authors.lastname: Barager
authors.forename: D M
authors.initials: DM
authors.lastname: Ward
authors.forename: M G
authors.initials: MG
authors.lastname: Ziegler
mesh_terms: D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D008676:Metanephrine / Q000097:blood; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D009647:Normetanephrine / Q000097:blood; D010530:Peritoneal Dialysis; D006435:Renal Dialysis
chemical_list: D009647:Normetanephrine; D008676:Metanephrine; D009320:Atrial Natriuretic Factor; D009638:Norepinephrine