title: The effects of omeprazole and cimetidine on duodenal ulcer healing and the relief of symptoms.
abstract: In a Swedish double-blind multicentre study, omeprazole (30 mg o.m.) was compared with the H2-receptor antagonist cimetidine (400 mg b.d.) in 152 patients. Clinical assessments and laboratory investigations were carried out at 2 and 4 weeks, and again at 6 weeks in unhealed patients. Endoscopy was performed at 2 weeks, and again at 4 and 6 weeks in unhealed patients. The patients in the two groups were well-matched prior to treatment. Omeprazole was superior to cimetidine in ulcer-healing rate after 2, 4 and 6 weeks. After 2 weeks of treatment, 66% of the omeprazole- and 45% of the cimetidine-treated patients were healed (P = 0.02), after 4 weeks 97 and 84% (P = 0.01), and after 6 weeks 100 and 92% (P = 0.02), respectively. There was a more pronounced improvement in the patients' symptoms in the omeprazole group after 2 weeks (P = 0.05). Both drugs were well-tolerated, but there was a high prevalence of patients with adverse events in the cimetidine group (51%, compared to 30% of the omeprazole group; P = 0.02). A total of 125 patients were followed for 6 months after healing. The patients were investigated by endoscopy after 6 months, or whenever symptoms occurred. There was no significant difference in the rate of relapse within 6 months between the two treatment groups: 54% relapsed in the omeprazole group and 52% in the cimetidine group. In conclusion, 30 mg of omeprazole, given once daily, is superior to 400 mg of cimetidine twice daily in duodenal ulcer healing; but ulcer relapse in the two groups appears to be equivalent.
authors.affiliation: Department of Surgery, University Hospital, Umeå, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Dahlgren
authors.forename: L
authors.initials: L
authors.lastname: Domellöf
authors.forename: M
authors.initials: M
authors.lastname: Hradsky
authors.forename: C
authors.initials: C
authors.lastname: Norryd
authors.forename: J
authors.initials: J
authors.lastname: Brunkwall
authors.forename: G
authors.initials: G
authors.lastname: Svensson
authors.forename: J O
authors.initials: JO
authors.lastname: Svensson
authors.forename: J
authors.initials: J
authors.lastname: Karlsson
authors.forename: U
authors.initials: U
authors.lastname: Knutson
authors.forename: T
authors.initials: T
authors.lastname: Gasslander
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002927:Cimetidine / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*
chemical_list: D002927:Cimetidine; D009853:Omeprazole