title: [Autoradiographic study of the ontogeny of the imipramine receptors in the cerebral cortex of rats].
abstract: Localization of 3H-imipramine binding sites in the cerebral cortex of rats was studied on the 19th day of prenatal development and on the 3d and 14th days of postnatal ontogenesis. Imipramine was injected into rats on days 17, 18 and 19 of gestation. The maximal imipramine receptor density was found in cortex layers IV-V. The therapeutic doses of imipramine provoked marked stimulation of the formation of imipramine receptors on the 3d day of postnatal development. However, on the 14th day the 3H-imipramine binding level was stabilized.
authors.forename: M V
authors.initials: MV
authors.lastname: Pirogova
authors.forename: A S
authors.initials: AS
authors.lastname: Pylaev
mesh_terms: D000818:Animals; D001345:Autoradiography; D002352:Carrier Proteins; D002540:Cerebral Cortex / Q000032:analysis / Q000187:drug effects / Q000196:embryology*; D005865:Gestational Age; D007099:Imipramine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000032:analysis* / Q000187:drug effects
chemical_list: D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D007099:Imipramine
vernacular_title: Avtoradiograficheskoe issledovanie ontogeneza imipraminovykh retseptorov kory golovnogo mozga krys.