title: Platelet alpha-adrenergic receptor activity and pizotifen in migrainous children.
abstract: Adrenoceptors have been measured in the platelets from migrainous children, using (3H) yohimbine. Maximum binding (Bmax) was not significantly different in migrainous children and controls, 259 +/- 21 and 265 +/- 19 f moles per mg of protein respectively. Dissociation constants (KD) were significantly higher in the migraine group than in the controls 2.62 +/- 0.18 and 2.17 +/- 0.07 respectively (p less than 0.02). Bmax values were lower in 6 out of 9 cases following treatment with pizotifen. In 8 out of 9 cases KD values were lower following pizotifen treatment; in one case there was no change.
authors.forename: P A
authors.initials: PA
authors.lastname: Bond
authors.forename: M A
authors.initials: MA
authors.lastname: Salmon
mesh_terms: D000293:Adolescent; D001792:Blood Platelets / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000097:blood* / Q000188:drug therapy; D010918:Pizotyline / Q000097:blood / Q000627:therapeutic use*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013876:Thiophenes / Q000627:therapeutic use*; D015016:Yohimbine / Q000097:blood
chemical_list: D011943:Receptors, Adrenergic, beta; D013876:Thiophenes; D010918:Pizotyline; D015016:Yohimbine