title: High frequency of triplicated alpha-globin loci and absence or low frequency of alpha thalassemia in Polynesian Samoans.
abstract: Most of the population in certain areas of Melanesia have one alpha-globin gene deletion (alpha thal2). It is thought that the high frequencies of alpha thal2 in this population is due to a selective advantage given by malaria infection to carriers of alpha thal2. We are interested in neighboring Polynesia which, although adjacent to Melanesia, has always been free of malaria due to the absence of the vector anopheles. We studied 60 Polynesian Samoans and 150 Malaysians by restriction endonuclease gene mapping using Eco RI, Bam HI, and Bgl II and hybridization to 32P-labeled alpha-globin gene probe. Seven among the 60 (11.7%) Samoans had triplicated alpha-globin loci type 1, while none had alpha thal2. On digestion with Bgl II the third alpha-globin gene was found in an additional 3.7 kb fragment in all seven Samoans with triplicated alpha-globin loci, while digestion with Bam HI produced an abnormal elongated 18.2 kb fragment carrying alpha-globin genes in addition to the normal 14.5 kb fragment. None of the Polynesian Samoans had alpha thal2 or alpha thal1. Only two of the Malaysians had triplicated alpha-globin loci.
authors.forename: L E
authors.initials: LE
authors.lastname: Lie-Injo
authors.forename: I G
authors.initials: IG
authors.lastname: Pawson
authors.forename: A
authors.initials: A
authors.lastname: Solai
mesh_terms: D000328:Adult; D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes; D004587:Electrophoresis, Agar Gel; D005006:Ethnicity; D005787:Gene Frequency; D005914:Globins / Q000235:genetics*; D006801:Humans; D014905:Independent State of Samoa; D008296:Malaysia; D013789:Thalassemia / Q000453:epidemiology / Q000235:genetics*; D014314:Trisomy
chemical_list: D005914:Globins; D004262:DNA Restriction Enzymes