title: Muscle spindle number is normal in guinea pigs with reduced dorsal root ganglia following in utero deprivation of nerve growth factor.
abstract: Muscle spindles are induced during embryonic development by contact between sensory axons and undifferentiated myotubes. Neonatal guinea pigs deprived of nerve growth factor in utero can have only 15-20% of the normal number of dorsal root ganglion cells. This study demonstrates that such neonates have normal numbers of muscle spindles. The remaining 15-20% of dorsal root ganglion cells may therefore largely be muscle afferents.
authors.affiliation: Department of Pathology, University of Western Australia, Nedlands.
authors.forename: N G
authors.initials: NG
authors.lastname: Laing
authors.forename: P A
authors.initials: PA
authors.lastname: Osborne
authors.forename: E M
authors.initials: EM
authors.lastname: Johnson
mesh_terms: D000818:Animals; D005333:Fetus / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000033:anatomy & histology* / Q000648:ultrastructure; D006168:Guinea Pigs; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009470:Muscle Spindles / Q000648:ultrastructure*; D009414:Nerve Growth Factors / Q000172:deficiency*
chemical_list: D009414:Nerve Growth Factors