title: TDI-induced oculorhinitis and bronchial asthma.
abstract: A case of allergic oculorhinitis induced by toluene diisocyanate (TDI) exposure in a subject who two years later developed bronchial asthma due to TDI is described. A 55-year-old nonatopic spray painter developed symptoms of oculorhinitis two or three hours after direct occupational exposure to polyurethane varnish; at the first examination neither specific nor nonspecific bronchial hyperresponsiveness was present. Two years later the patient, who had remained in his job, developed episodic dyspnea, wheezing, and cough immediately after TDI exposure, with persistence of oculorhinitis; at this time a slight immediate-type response to a specific bronchial provocative test with polyurethane varnish and TDI was observed. Nonspecific bronchial hyperresponsiveness was mild. Specific IgE to TDI-HSA conjugate was present at both the first and second examinations. We conclude that, in some cases, TDI may cause "allergic" oculorhinitis and bronchial asthma, probably with an immunological IgE-mediated mechanism.
authors.forename: P L
authors.initials: PL
authors.lastname: Paggiaro
authors.forename: O
authors.initials: O
authors.lastname: Rossi
authors.forename: L
authors.initials: L
authors.lastname: Lastrucci
authors.forename: F
authors.initials: F
authors.lastname: Pardi
authors.forename: A
authors.initials: A
authors.lastname: Pezzini
authors.forename: L
authors.initials: L
authors.lastname: Baschieri
mesh_terms: D001249:Asthma / Q000139:chemically induced*; D001985:Bronchial Provocation Tests; D003485:Cyanates / Q000009:adverse effects*; D009877:Endophthalmitis / Q000139:chemically induced*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced*; D010150:Paint / Q000009:adverse effects; D012220:Rhinitis / Q000139:chemically induced*; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects*
chemical_list: D003485:Cyanates; D014051:Toluene 2,4-Diisocyanate; D007073:Immunoglobulin E