Effect of an orally administered arotinoid, Ro 15-0778, on sebum production in man.
1,2,3,4-Tetrahydro-1,1,4,4-tetramethyl-y-[(E)-alpha-methylstyryl]- naphthalene (Ro 15-0778), a potent inhibitor of sebaceous gland activity in several animal models has been administered to male volunteers in dosages of 1, 2, 3, and 6 mg/kg/day and 2 g/day for 8 weeks. Sebum production was measured before treatment and after 4 and 8 weeks of therapy. At the dosage levels of 1, 2, 3, and 6 mg/kg/day there was no decrease in sebum secretion. With the dosage of 2 g/day, a significant decrease in sebum secretion was seen after 8 weeks of treatment with Ro 15-0778.
Strauss
J S
JS
Department of Dermatology, University of Iowa College of Medicine, Iowa 52242.
Davey
W P
WP
Denton
S J
SJ
Stranieri
A M
AM
D000152:Acne Vulgaris / Q000188:drug therapy / Q000503:physiopathology; D000284:Administration, Oral; D003864:Depression, Chemical; D006801:Humans; D008297:Male; D012176:Retinoids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012627:Sebaceous Glands / Q000187:drug effects* / Q000378:metabolism; D012629:Sebum / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects
D012176:Retinoids; C053595:temarotene