Zearalenone metabolism and excretion in the rat: effect of different doses.
Young female rats were orally dosed with either 1 or 100 mg zearalenone kg-1 body weight; zearalenone and metabolites were measured in a 96-h collection of urine and feces by HPLC analysis. Dose had little effect on metabolites formed, or excretion route. In both treatment groups, about 55% of the oral dose was excreted in the feces, while the urine was also a major route of excretion accounting for 15-20% of the administered dose. Zearalenone and metabolites were excreted mainly in the free form, with the production of alpha-zearalenol, the most potent estrogenic metabolite, being greater than 10% of the zearalenone dose.
Fitzpatrick
D W
DW
Department of Foods and Nutrition, University of Manitoba, Winnipeg.
Arbuckle
L D
LD
Hassen
A M
AM
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000032:analysis; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D012118:Resorcinols / Q000378:metabolism*; D015025:Zearalenone / Q000378:metabolism* / Q000652:urine; D015029:Zeranol / Q000031:analogs & derivatives / Q000378:metabolism
D012118:Resorcinols; C029659:zearalenol; D015025:Zearalenone; D015029:Zeranol