title: [Functional anatomy of the left ventricle in hypertensive subjects. Correlations with the clinical severity of hypertension].
abstract: Using computerized M-mode echocardiography we have investigated 58 hypertensive subjects in order to assess whether a correlation could be demonstrated between left ventricular changes induced by hypertension and age of the patients, the duration and severity of hypertension, and damage to other target organs. Various morphological changes of the left ventricle were detected: 14 patients (24%) had concentric hypertrophy of the left ventricle, 12 (20%) had asymmetric septal hypertrophy, 5 (8%) had dilated left ventricle without hypertrophy. Left ventricular mass was increased, when compared to normal controls in 24 patients (41%). With respect to functional abnormalities, the peak lengthening rate of left ventricular dimension in diastole was decreased (+dD/dt less than s-1) in 25 patients (43%). Eight of these patients (14%) also had depressed peak shortening rate of left ventricular diameter in systole (-dD/dt less than 1.9 s-1). Hypertensive retinopathy was present in 23 patients (39%) and impairment of renal function in 8 (14%). Left ventricular mass and systolic and diastolic parameters of left ventricular function did not correlate significantly either with the age of the patients, or with the duration and severity of hypertension, or with the damage present in target organs other than the heart. Left ventricular mass was inversely correlated with the index of left ventricular relaxation (r = -0.53; P less than 0.001), whereas neither the latter nor left ventricular mass were correlated with peak systolic stress. Instead, peak systolic stress was inversely correlated with peak shortening rate of left ventricular diameter, an index of systolic function (r = -0.50; P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Dipartimento di Medicina Interna I.R.C.C.S. Policlinico San Matteo, Pavia.
authors.forename: A
authors.initials: A
authors.lastname: Venco
authors.forename: A M
authors.initials: AM
authors.lastname: Grandi
authors.forename: F
authors.initials: F
authors.lastname: Barzizza
authors.forename: G D
authors.initials: GD
authors.lastname: Malamani
authors.forename: M
authors.initials: M
authors.lastname: Franchini
authors.forename: G
authors.initials: G
authors.lastname: Finardi
mesh_terms: D000328:Adult; D006332:Cardiomegaly / Q000473:pathology* / Q000503:physiopathology; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
vernacular_title: Anatomia funzionale del ventricolo sinistro in soggetti ipertesi. Correlazioni con la gravità clinica dell'ipertensione.