Reexamination of glucose-6-phosphatase activity in the brain in vivo: no evidence for a futile cycle.
Glucose-6-phosphatase activity in the rat brain in vivo was estimated by measuring the differential loss of tritium and carbon-14 from the glucose pool labeled by a mixture of [2-3H]glucose and [U-14C]glucose. The results provide no evidence of significant dephosphorylation of glucose-6-phosphate and do not support the hypothesis of a futile cycle involving glucose-6-phosphatase activity in the brain.
Nelson
T
T
Lucignani
G
G
Atlas
S
S
Crane
A M
AM
Dienel
G A
GA
Sokoloff
L
L
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D005958:Glucosephosphates / Q000378:metabolism*; D006019:Glycolysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005958:Glucosephosphates; D005952:Glucose-6-Phosphatase; D005947:Glucose