[Effect of beta-endorphin on the development of denervation changes in the membrane of the muscle fiber in the rat].
A decrease in the resting membrane potential, an increase in the input resistance, appearance of the anode breakdown and tetrodotoxin-resistant action potentials and extrajunctional acetylcholine sensitivity following denervation were revealed in surviving rat diaphragm muscle fibres. Addition of beta-endorphin (1.10(-8) M) to the culture medium prevented on increase in the input resistance and reduced a degree of the extrajunctional acetylcholine sensitivity, but did not inhibit the appearance of the anode breakdown and tetrodotoxin-resistant action potentials. Naloxone (1.25.10(-6) M) did not avert the effect of beta-endorphin, more over it exerted a beta-endorphin-like effect on the denervated muscle fibres. It is suggested that beta-endorphin can be the factor which is responsible for the neurotrophic control of passive electrical properties of the muscle fibre membrane and neurotrophic regulation of the membrane sensitivity to acetylcholine.
Chikin
A V
AV
Urazaev
A Kh
AKh
Volkov
E M
EM
Poletaev
G I
GI
Khamitov
Kh S
KhS
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003964:Diaphragm / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009121:Muscle Denervation; D009132:Muscles / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D013779:Tetrodotoxin / Q000494:pharmacology; D001615:beta-Endorphin / Q000494:pharmacology*
D009270:Naloxone; D013779:Tetrodotoxin; D001615:beta-Endorphin; D000109:Acetylcholine
Vliianie beta-éndorfina na razvitie denervatsionnykh izmeneniĭ membrany myshchechnogo volokna krysy.