title: Imaging of cerebral blood flow markers in Huntington's disease using single photon emission computed tomography.
abstract: Single photon emission computed tomography (SPECT) imaging of six Huntington's disease patients revealed a striking reduction in regional uptake of cerebral blood flow markers in vivo. Similar changes were found in one patient with "early stage" disease. The findings are compared with parallel magnetic resonance imaging (MRI) studies, and in one case, results of postmortem examination.
authors.affiliation: Department of Mental Health, University of Aberdeen, Foresterhill, UK.
authors.forename: I C
authors.initials: IC
authors.lastname: Reid
authors.forename: J A
authors.initials: JA
authors.lastname: Besson
authors.forename: P V
authors.initials: PV
authors.lastname: Best
authors.forename: P F
authors.initials: PF
authors.lastname: Sharp
authors.forename: H G
authors.initials: HG
authors.lastname: Gemmell
authors.forename: F W
authors.initials: FW
authors.lastname: Smith
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D002421:Caudate Nucleus / Q000098:blood supply; D002560:Cerebrovascular Circulation; D006801:Humans; D006816:Huntington Disease / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009942:Organometallic Compounds; D010091:Oximes; D012307:Risk Factors; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed
chemical_list: D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime