title: Drug-induced paralysis (muscle relaxant) therapy in the mechanically ventilated neonate.
abstract: Drug-induced paralysis in the mechanically ventilated neonate is prescribed primarily to control breathing and, secondarily, to favorably affect underlying pulmonary disease and associated complications. Although the control of breathing can be achieved, it is controversial when pulmonary disease is favorably influenced by paralysis. However, such therapy may lessen the severity, and the incidence of the complications in specific subgroups of infants. In view of significant adverse effects, muscle paralysis should be used judiciously in neonates.
authors.affiliation: Department of Pediatrics, Medical University of South Carolina, Charleston 29425.
authors.forename: J E
authors.initials: JE
authors.lastname: Moss
authors.forename: D M
authors.initials: DM
authors.lastname: Purohit
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D010243:Paralysis / Q000139:chemically induced*; D012121:Respiration, Artificial
chemical_list: D003473:Neuromuscular Nondepolarizing Agents