The effect of zinc on vitamin D3-induced cardiac necrosis.
Multifocal heart muscle necrotic lesions in rats were induced with high oral doses of vitamin D3 (300,000 iu/rat in three daily doses 100 000 iu each). The calcium content increased over 100 fold in the hearts of rats receiving vitamin D3. Parenteral pre-treatment with zinc sulphate (50 or 200 mg/rat in ten daily doses) resulted either in a reduction or in the total prevention of myocardial lesions on macroscopic, light and electron microscopic examination. The effect of zinc was dose-dependent. The administration of various doses of zinc sulphate resulted in a gradual normalization of heart calcium content.
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D000818:Animals; D002118:Calcium / Q000032:analysis; D002762:Cholecalciferol / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006321:Heart / Q000187:drug effects*; D008274:Magnesium / Q000032:analysis; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure*; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000032:analysis / Q000494:pharmacology*
D002762:Cholecalciferol; D008274:Magnesium; D015032:Zinc; D002118:Calcium