Activated idiotype-reactive cells in suppressor/cytotoxic subpopulations of monoclonal gammopathies: correlation with diagnosis and disease status.
The phenotypic pattern of peripheral blood T (PBT) lymphocytes was correlated with diagnosis and clinical status in 63 patients with monoclonal gammopathies (MGs). The numbers of lymphocytes expressing activation and CD11 determinants were significantly increased in suppressor/cytotoxic and helper/inducer subpopulations of patients with multiple myeloma (MM) and MG of undetermined significance (MGUS). The number of activated suppressor/cytotoxic cells was closely correlated with diagnosis and disease status. These cells were significantly higher in MM at diagnosis (160 +/- 88) than MGUS patients (61 +/- 79; P less than .01). Their number decreased to MGUS levels in MM in stable remission (58 +/- 53), but not in MM with tumor progression (172 +/- 102; P less than .001). In individual patients, part of these cells specifically adhered to dishes precoated with the related M-protein. No monoclonal T-beta gene rearrangement was detected in PBT and cytotoxic/suppressor subpopulations from two patients with a large proportion of activated cells.
Dianzani
U
U
Department of Medicine and Experimental Oncology, University of Torino, Italy.
Pileri
A
A
Boccadoro
M
M
Palumbo
A
A
Pioppo
P
P
Bianchi
A
A
Camponi
A
A
Fossati
G
G
Battaglio
S
S
Massaia
M
M
D001798:Blood Proteins / Q000502:physiology; D002448:Cell Adhesion; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000502:physiology*; D007075:Immunoglobulin M / Q000502:physiology; D007136:Immunoglobulins; D008213:Lymphocyte Activation; D010265:Paraproteinemias / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D010641:Phenotype; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000502:physiology*
D001798:Blood Proteins; D007130:Immunoglobulin Idiotypes; D007075:Immunoglobulin M; D007136:Immunoglobulins; C009823:M-proteins (Myeloma); D011948:Receptors, Antigen, T-Cell