Effects of heptaminol AMP amidate on suppressor and helper function of murine T cells.
Heptaminol AMP amidate (HAA), a newly developed nucleotide derivative, was found to restore the immunosuppression in mice due to the induction of suppressor T (Ts) cells by concanavalin A (Con A) (50 micrograms/body). HAA also inhibited Con A-mediated in vitro induction of Ts cells. On the contrary, the administration of HAA in mice primed with keyhole lympet hemocyanin (KLH) (30 micrograms/body) caused an enhanced induction of antigen specific helper T (Th) cells. Effects of HAA on Ts and Th cells were found to be dependent on their level of induction. The administration of HAA also increased the spleen cell number and augmented the plaque forming cell response to some extent in cyclophosphamide treated mice. The present results suggested that HAA-mediated immunopotentiation was possible by a combined suppressive effect on Ts cells and enhancing effect on Th cells.
Saha
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AR
Laboratory of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Ueno
K
K
Ohmori
S
S
Igarashi
T
T
Kitagawa
H
H
D000249:Adenosine Monophosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D000276:Adjuvants, Immunologic; D000605:Amino Alcohols / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation; D003208:Concanavalin A / Q000494:pharmacology; D003520:Cyclophosphamide / Q000633:toxicity; D006433:Hemocyanins / Q000494:pharmacology; D006535:Heptaminol / Q000031:analogs & derivatives / Q000494:pharmacology*; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology
D000276:Adjuvants, Immunologic; D000605:Amino Alcohols; D003208:Concanavalin A; D006535:Heptaminol; D000249:Adenosine Monophosphate; C053918:heptaminol AMP amidate; D003520:Cyclophosphamide; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin