title: [Controlled randomized prospective study of a ceftazidime-pefloxacin combination versus a ceftazidime-amikacin combination in the empirical treatment of nosocomial pneumonias and septicemias of resuscitation. Preliminary results].
abstract: The preliminary results obtained in 212 patients from 20 intensive care units, suffering from pneumonia or nosocomial septicemia and treated at random with either ceftazidime + pefloxacin (CP) or ceftazidime + amikacin (CA) were analyzed. After exclusion of patients who did not comply with the protocol and of cases where no organism was isolated, 57 assessable patients received CP and 72 received CA. The cure rates achieved in infections due to a single organism were 85 per cent in the CA group and 63 per cent in the CP group. In infections due to multiple organisms, the cure rate was 74 +/- 2 per cent with both antibiotic regimens.
authors.affiliation: Unité de Réanimation du Service régional des maladies infectieuses, Tourcoing.
authors.forename: Y
authors.initials: Y
authors.lastname: Mouton
authors.forename: C
authors.initials: C
authors.lastname: Beuscart
authors.forename: O
authors.initials: O
authors.lastname: Leroy
authors.forename: M
authors.initials: M
authors.lastname: Pappo
authors.forename: H
authors.initials: H
authors.lastname: Drugeon
mesh_terms: D000583:Amikacin / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D002442:Ceftazidime / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003428:Cross Infection / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D015366:Pefloxacin / Q000627:therapeutic use*; D011014:Pneumonia / Q000188:drug therapy*; D011446:Prospective Studies; D011897:Random Allocation
chemical_list: D015366:Pefloxacin; D000583:Amikacin; D002442:Ceftazidime
vernacular_title: Etude prospective randomisée contrôlée de l'association ceftazidime-péfloxacine versus ceftazidime-amikacine dans le traitement empirique des pneumonies et septicémies nosocomiales de réanimation. Résultats préliminaires.