title: On the preparation of dihematoporphyrin ether-free hematoporphyrin derivative.
abstract: A dihematoporphyrin ether-free hematoporphyrin derivative has been prepared by a base-catalysed dehydration of hematoporphyrin with sodium hydroxide. The identification was performed by HPLC and mass spectroscopy (FD-MS). The reaction of hematoporphyrin with 1 M sodium hydroxide for 24 h yields more than 90% of the monomeric porphyrins.
authors.affiliation: Abteilung für Klinische Biochemie im Fachbereich Humanmedizin der Philipps Universität Marburg.
authors.forename: H
authors.initials: H
authors.lastname: Häberlein
authors.forename: P
authors.initials: P
authors.lastname: Both
authors.forename: M O
authors.initials: MO
authors.lastname: Doss
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D017323:Dihematoporphyrin Ether; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000138:chemical synthesis* / Q000302:isolation & purification; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D013053:Spectrophotometry
chemical_list: D000970:Antineoplastic Agents; D006415:Hematoporphyrins; D007202:Indicators and Reagents; D017324:Hematoporphyrin Derivative; D017323:Dihematoporphyrin Ether