title: Placental-site trophoblastic tumor (trophoblastic pseudotumor): case report demonstrating failure of chemotherapy, surgery, and radiotherapy to control metastatic disease.
abstract: A case of metastatic placental-site trophoblastic tumor (trophoblastic pseudotumor) is presented and compared to four previously reported cases. Chemotherapy with MAC (methotrexate, dactinomycin, cyclophosphamide), aggressive surgical debulking, and radiotherapy were ineffective in producing disease regression. Only two of the four similar cases in the literature showed short responses (4-7 months) to several different aggressive multiagent chemotherapy regimens. Optimal therapeutic outcome is likely to result from an early diagnosis and aggressive surgical treatment of localized tumor.
authors.forename: W E
authors.initials: WE
authors.lastname: Samlowski
authors.forename: T M
authors.initials: TM
authors.lastname: Abbott
authors.forename: D E
authors.initials: DE
authors.lastname: Kepas
authors.forename: H J
authors.initials: HJ
authors.lastname: Eyre
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006063:Chorionic Gonadotropin / Q000032:analysis; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D010920:Placenta; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*
chemical_list: D006063:Chorionic Gonadotropin