title: Sodium-potassium-ATPase activity in the dorsal root ganglia of rats with streptozotocin-induced diabetes.
abstract: Sodium-potassium-ATPase activity was measured in excised dorsal root ganglia of streptozotocin-diabetic rats, 2 months after induction of diabetes. In comparison with age-matched controls, there was a decrease in both the total and ouabain-insensitive activity, indicating an overall reduction in ouabain-sensitive activity of 46%. This decrease may explain the reduced amino-acid uptake exhibited by diabetic sensory ganglia and could be relevant to the development of diabetic neuropathy.
authors.forename: R J
authors.initials: RJ
authors.lastname: Green
authors.forename: R H
authors.initials: RH
authors.lastname: King
authors.forename: P K
authors.initials: PK
authors.lastname: Thomas
authors.forename: D N
authors.initials: DN
authors.lastname: Baron
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D005727:Ganglia, Spinal / Q000201:enzymology*; D008297:Male; D010042:Ouabain / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase