Neurite formation modulated by nerve growth factor, insulin, and tumor promoter receptors.
Until recently, nerve growth factor could be considered the only neurotrophic factor with an established physiological role. We discuss the emerging evidence indicating that the insulinlike factors may constitute a family of related neurotrophic proteins, and the observations suggesting that the receptor for the phorbol ester tumor promoters is closely associated with neuronal differentiation. The emphasis of the discussion is placed on neurite formation under multiple modulation by insulinlike factors, nerve growth factor, and tumor promoter receptors in sensory, sympathetic and human neuroblastoma cells.
Ishii
D N
DN
Recio-Pinto
E
E
Spinelli
W
W
Mill
J F
JF
Sonnenfeld
K H
KH
D000818:Animals; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D002454:Cell Differentiation; D002460:Cell Line; D066246:ErbB Receptors; D006801:Humans; D007328:Insulin / Q000502:physiology*; D009414:Nerve Growth Factors / Q000502:physiology*; D009420:Nervous System / Q000166:cytology*; D009447:Neuroblastoma; D009474:Neurons / Q000166:cytology; D010455:Peptides / Q000502:physiology; D011493:Protein Kinase C; D011956:Receptors, Cell Surface / Q000502:physiology*; D011955:Receptors, Drug; D011971:Receptors, Immunologic / Q000502:physiology; D017475:Receptors, Nerve Growth Factor; D011984:Sensory Receptor Cells / Q000502:physiology; D013002:Somatomedins / Q000502:physiology; D013564:Sympathetic Nervous System / Q000166:cytology
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D007328:Insulin; D009414:Nerve Growth Factors; D010455:Peptides; D011956:Receptors, Cell Surface; D011955:Receptors, Drug; D011971:Receptors, Immunologic; D017475:Receptors, Nerve Growth Factor; D013002:Somatomedins; C083141:phorbol ester binding protein; C027776:phorbol ester receptor; D066246:ErbB Receptors; D011493:Protein Kinase C