title: Use of febantel or ivermectin for treatment of calves with experimentally induced Bunostomum phlebotomum infection.
abstract: In the first of 2 separate trials, the efficacy of febantel, given at a dosage of 5 mg/kg of body weight, was assessed in calves with 60-day experimentally induced Bunostomum phlebotomum infection. Ten calves were given febantel paste, and 10 were given the vehicle only. All 20 calves were necropsied 7 days after cessation of treatment. Compared with untreated calves, febantel-treated calves harbored 99.4% fewer nematodes. In the second trial, the efficacy of ivermectin, given as a paste formulation at a dosage of 0.2 mg/kg, was assessed in calves with experimentally induced B phlebotomum infection. Ivermectin was given at 18 (n = 6) and 60 (n = 6) days after infection. At each treatment date, 3 additional calves were given vehicle only. At 67 days after infection, all calves were euthanatized. Efficacies of ivermectin against 18- and 60-day infections were 100 and 99.8%, respectively. Both anthelmintic preparations were easily administered, and adverse reactions were not observed.
authors.affiliation: Department of Animal Science, University of Arkansas, Fayetteville 72701.
authors.forename: T A
authors.initials: TA
authors.lastname: Yazwinski
mesh_terms: D000723:Ancylostomatoidea / Q000187:drug effects / Q000302:isolation & purification; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D006146:Guanidines / Q000627:therapeutic use*; D006725:Hookworm Infections / Q000188:drug therapy* / Q000469:parasitology; D007559:Ivermectin / Q000627:therapeutic use*
chemical_list: D006146:Guanidines; D007559:Ivermectin; C017309:febantel