Reduced venous compliance and increased transcapillary escape of protein in insulin-dependent diabetic patients.
Lower limb venous compliance and transcapillary escape rate of transferrin were measured in eight normotensive, insulin-dependent male diabetic patients and eight control subjects using a dual isotope technique. Technetium-99m labelled autologous erythrocytes were used to measure venous compliance and to correct for local changes in blood volume, whilst Indium-113m labelled transferrin was used to measure transcapillary escape of protein. The diabetic patients were found to have reduced venous compliance 1.5 (0.7 to 3.4) x 10(-2) mmHg-1 compared with controls 3.2 (2.4 to 4.1) x 10(-2) mmHg-1 (p less than 0.01). The diabetic patients were also found to have greater transcapillary escape of transferrin -2.7 (-1.5 to -5.3) x 10(-3), compared with control subjects -5.2 (-4.1 to -8.1) x 10(-3) (p less than 0.02) in response to increasing hydrostatic pressure. These results show reduced venous compliance in patients with a mean duration of diabetes of 15 years and with only at most, early complications of diabetes, and confirm previous observations showing increased transcapillary escape of protein.
Bell
D
D
Department of Medicine, Royal Infirmary, Edinburgh, UK.
Collier
A
A
Nicoll
J J
JJ
Jackson
M
M
Millar
A M
AM
Clarke
B F
BF
Muir
A L
AL
D000328:Adult; D000419:Albuminuria; D001794:Blood Pressure; D001798:Blood Proteins / Q000378:metabolism; D002199:Capillary Permeability; D003187:Compliance; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D012016:Reference Values; D013667:Technetium; D014680:Veins / Q000503:physiopathology*
D001798:Blood Proteins; D006442:Glycated Hemoglobin; D007205:Indium Radioisotopes; D013667:Technetium