[Presynaptic autoregulation of dopamine release].
Experiments in vivo with local perfusion of rat brain neostriatum revealed existence of autoregulation of dopamine release mediated by presynaptic dopamine autoreceptors. An increase in dopamine concentration in the perfusion medium (addition of exogenous dopamine 10(-7) M, or cocaine, the inhibitor of uptake of biogenous amines, 10(-6) M) leads to a decrease in K+--induced release into perfusate of 3H--dopamine preliminarily injected into neostriatum. Haloperidol (10(-6) M) abolishes the inhibitory effect of exogenous dopamine. Perfusion with dopamine--containing medium (10(-4) M) leads to a decrease in the amplitude of EPs recorded in the neostriatum upon electrical stimulation of zona compacta of substantia nigra, indicating that dopamine release from dopaminergic terminals of nigro--striatal neurons decreases in response to AP.
Zharikova
A D
AD
Godukhin
O V
OV
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D004558:Electric Stimulation; D006706:Homeostasis / Q000187:drug effects; D008297:Male; D010477:Perfusion / Q000379:methods; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*
D011954:Receptors, Dopamine; D017981:Receptors, Neurotransmitter; D011188:Potassium; D004298:Dopamine
Presinapticheskaia autoreguliatsiia vysvobozhdeniia dofamina.