Auditory P300 response in the assessment of Alzheimer's disease in Down's syndrome: a 2-year follow-up study.
Sixty-five subjects with Down's syndrome were followed up and retested 2 years after the initial recording of auditory P300 (P3) event-related potential described in a companion paper (Blackwood et al., 1988). The number of subjects showing clinical evidence for Alzheimer's type dementia had increased by a further 14%. In subjects showing clinical deterioration over a period of 2 years, 78% (7/9) had an increase in P3 latency which was three standard deviations or greater than the group mean. None of the 20 fragile-X group retested showed significant change after 2 years. The results suggest that P3 change may be a sensitive index of the onset of Alzheimer's type dementia in Down's syndrome.
Muir
W J
WJ
University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, Scotland.
Squire
I
I
Blackwood
D H
DH
Speight
M D
MD
St Clair
D M
DM
Oliver
C
C
Dickens
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology; D004314:Down Syndrome / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory; D005260:Female; D005500:Follow-Up Studies; D005600:Fragile X Syndrome / Q000503:physiopathology; D006801:Humans; D008607:Intellectual Disability / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D012815:Signal Processing, Computer-Assisted