Copulatory performance of penile desensitized male rats following the administration of 8-OH-DPAT.
Bilateral transection of the dorsal penile nerve in male rats was followed by reduction of the amount of intromissions in relation to the frequency of mounts and abolishment of the capacity to ejaculate. Treatment with 8-OH-DPAT (0.25 mg.kg-1 -20 min SC) essentially normalized the behavior of the operated animals which showed a normal proportion of mounts to intromissions and which all ejaculated at almost all testing occasions. It was speculated that treatment with 8-OH-DPAT makes central neural mechanisms more responsive to genital stimulation thereby facilitating the development of full penile erection, vaginal insertion and intromission.
Dahlöf
L G
LG
University of Göteborg, Department of Psychology, Sweden.
Ahlenius
S
S
Larsson
K
K
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D003307:Copulation / Q000187:drug effects*; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D010413:Penis / Q000294:innervation*; D051381:Rats; D011919:Rats, Inbred Strains; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D009281:Naphthalenes; D013764:Tetrahydronaphthalenes; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin