Hematoporphyrin derivative photosensitization and cellular fluorescent photoproduct formation.
A new fluorescence band with an emission maximum at 460 nm was observed in S180 tumour cells and human cancer tissues photosensitized by Y-HPD. This fluorescence was the result of a photochemical reaction involving specific proteins and Y-HPD in the cells.
Cao
E H
EH
Institute of Biophysics, Academia Sinica, Beijing, China.
Fan
X J
XJ
Chi
S J
SJ
Wang
Y X
YX
D000818:Animals; D001711:Biotransformation; D002467:Cell Nucleus / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D002843:Chromatin / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000378:metabolism*; D006801:Humans; D008027:Light; D051379:Mice; D011838:Radiation-Sensitizing Agents / Q000378:metabolism*; D012510:Sarcoma 180 / Q000378:metabolism* / Q000473:pathology; D013050:Spectrometry, Fluorescence; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000378:metabolism*; D014466:Ultraviolet Rays
D002843:Chromatin; D006415:Hematoporphyrins; D011838:Radiation-Sensitizing Agents; D017324:Hematoporphyrin Derivative