[Binary ethyleneimine as an inactivator of the foot-and-mouth disease virus].
Experiments were carried out to inactivate F.M.D. viruses with the use of binary ethylene-imine. It was found that inactivation was optimal when the agent was used at the rate of 0.003 M for 18 hours at 26 degrees C. Its neutralization in the virus suspension was carried out with 3 mM sodium thiosulfate. The inactivated F.M.D. viruses retained their complement-fixing and immunogenic properties. Discussed are the advantages of using binary ethyleneimine as an inactivating agent as against other agents of the asiridine order.
Tekerlekov
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P
Veleva
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E
D000956:Antigens, Viral / Q000032:analysis; D005537:Aphthovirus / Q000187:drug effects* / Q000276:immunology; D001388:Aziridines / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D003168:Complement Fixation Tests; D006386:Hemagglutination Tests; D014613:Vaccines, Attenuated / Q000302:isolation & purification; D014765:Viral Vaccines / Q000302:isolation & purification; D014775:Virus Activation / Q000187:drug effects*; D014776:Virus Cultivation
D000956:Antigens, Viral; D001388:Aziridines; D001389:Azirines; D014613:Vaccines, Attenuated; D014765:Viral Vaccines; C033132:aziridine
Binerniiat etilenimin kato inaktivator na shapniia virus.