title: Transluminal coronary angioplasty in the treatment of silent ischemia.
abstract: Fifty-four asymptomatic patients with positive thallium exercise tests underwent coronary angiography followed by coronary angioplasty (PTCA), as the primary therapy for silent ischemia. The procedure was technically successful in 89% of these patients. Emergency bypass graft surgery was necessary in 2 (3.6%) and q-wave myocardial infarction occurred in 1 (1.8%) of these. All fifty-four patients have been followed for a mean of 35 months since angioplasty. Of the 48 patients with initially successful PTCA, 12 had either clinical restenosis (9/14 or 19%) or a new lesion (3/48 or 6%) during follow-up, which required a repeat PTCA. At the longest follow-up, 46 (85%) had been successfully treated with on or more PTCA procedures. Two patients (3.6%) had sustained late q-wave myocardial infarction and two additional patients reported angina pectoris. There were no deaths. Angioplasty as a primary therapy for silent ischemia appears efficacious, with success and restenosis rates comparable to those in the symptomatic population. Event-free survival is improved, compared with natural history data for patients with silent ischemia from other studies. Prudent risk/benefit analysis may help to define subgroups most likely to benefit from this intervention.
authors.affiliation: San Francisco Heart Institute, Seton Medical Center, Daly City, California 94015.
authors.forename: P
authors.initials: P
authors.lastname: Bergin
authors.forename: R K
authors.initials: RK
authors.lastname: Myler
authors.forename: R E
authors.initials: RE
authors.lastname: Shaw
authors.forename: S H
authors.initials: SH
authors.lastname: Stertzer
authors.forename: D A
authors.initials: DA
authors.lastname: Clark
authors.forename: C
authors.initials: C
authors.lastname: Ryan
authors.forename: M C
authors.initials: MC
authors.lastname: Murphy
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris; D000800:Angioplasty, Balloon; D003327:Coronary Disease / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging