Salmonid melanin-concentrating hormone inhibits corticotrophin release.
Melanin-concentrating hormone (MCH) is a neural peptide associated with colour change in fishes. We show here that it also inhibits corticotrophin (ACTH) secretion. Synthetic salmonid MCH at a concentration of 100pmol/l reduced the in-vitro release of ACTH by pars distales (pDs) taken from stressed trout. At lower concentrations (10pmol/l) the peptide inhibited CRF-41-induced secretion of ACTH by pDs removed from unstressed trout, while at higher concentrations (10nmol/l) it reduced the corticotrophic response of rat pituitary tissue to CRF-41.
Baker
B I
BI
Bird
D J
DJ
Buckingham
J C
JC
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D003864:Depression, Chemical; D006728:Hormones / Q000494:pharmacology*; D007028:Hypothalamic Hormones; D066298:In Vitro Techniques; D008543:Melanins / Q000494:pharmacology*; D008547:Melanophores / Q000187:drug effects*; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism; D010907:Pituitary Hormones / Q000494:pharmacology*; D051381:Rats; D013312:Stress, Physiological; D014337:Trout
D006728:Hormones; D007028:Hypothalamic Hormones; D008543:Melanins; D010907:Pituitary Hormones; C019463:melanin-concentrating hormone; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone