title: Some mismatch repair activities in Escherichia coli.
abstract: Heterozygous bacteriophage lambda DNA molecules, whose replication requires mismatch correction of a mutant nucleotide in the transcribed strand, provide an assay for localized mismatch repair in Escherichia coli. We describe two systems: one removes the A in C.A or G.A mismatches and the other removes one or the other C in a C.C mismatch. Mutations disabling the first system result in a mutator phenotype that may be identical to mutY.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
authors.forename: J P
authors.initials: JP
authors.lastname: Radicella
authors.forename: E A
authors.initials: EA
authors.lastname: Clark
authors.forename: M S
authors.initials: MS
authors.lastname: Fox
mesh_terms: D000225:Adenine; D010582:Bacteriophage lambda / Q000235:genetics; D001483:Base Sequence; D002874:Chromosome Mapping; D003562:Cytidine; D004260:DNA Repair; D004926:Escherichia coli / Q000235:genetics*; D006147:Guanine; D008745:Methylation; D009154:Mutation; D010641:Phenotype; D011995:Recombination, Genetic
chemical_list: D003562:Cytidine; D006147:Guanine; D000225:Adenine