title: Hypoalbuminemia-related platelet hypersensitivity in two dogs with nephrotic syndrome.
abstract: Platelet aggregation studies in 2 dogs with nephrotic syndrome disclosed increased platelet sensitivity to a low dose of adenosine diphosphate. Subsequent studies with isolated platelets and plasma indicated that a plasma factor was responsible primarily for inducing platelet hypersensitivity. The increased platelet aggregation response was corrected by increasing the albumin concentration of the plasma. The study suggested an important role for albumin in modulating platelet aggregation and may partially explain the tendency toward thrombosis noted in hypoalbuminemic dogs with nephrotic syndrome.
authors.forename: R A
authors.initials: RA
authors.lastname: Green
authors.forename: E A
authors.initials: EA
authors.lastname: Russo
authors.forename: R T
authors.initials: RT
authors.lastname: Greene
authors.forename: A L
authors.initials: AL
authors.lastname: Kabel
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D000990:Antithrombin III / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D004285:Dogs; D005340:Fibrinogen / Q000378:metabolism; D009404:Nephrotic Syndrome / Q000097:blood / Q000662:veterinary*; D010974:Platelet Aggregation; D012709:Serum Albumin / Q000172:deficiency* / Q000378:metabolism
chemical_list: D012709:Serum Albumin; D000244:Adenosine Diphosphate; D000990:Antithrombin III; D005340:Fibrinogen; D000242:Cyclic AMP