The stimulatory effect of a single intravenous dose of propranolol of some immune parameters in humans.
Propranolol (PRO) is a beta-adrenergic receptor antagonist. The studies were aimed to evaluate the effect of a single intravenous PRO injection at a dose of 0.1 mg/kg on some immune parameters, and were performed on 12 men, including 9 duodenal ulcer patients and 3 healthy subjects, aged 19-23 years (mean 20.5 +/- 1.2). Blood samples were drawn before, 30 and 150 min following the injection. Results obtained in duodenal ulcer patients and healthy subjects revealed the same type of changes. A single PRO injection did not significantly affect total peripheral blood lymphocyte, Th cell and monocyte counts; however, it slightly but significantly lowered numbers of T and Ts cells, which was accompanied by a rise in Th/Ts cell number ratio and NK cell numbers. PRO significantly augmented spontaneous as well as PHA-stimulated IL-2 receptor expression, IL-2 generation, NK cell activity and AMLR observed at 30 and 150 min after the drug injection. Possible mechanisms of these changes are discussed.
Malec
P
P
1st Department of Internal Medicine, School of Medicine, Tódź, Poland.
Markiewicz
K
K
Tchórzewski
H
H
Zeman
K
K
Baj
Z
Z
Nowak
Z
Z
Majewska
E
E
D000328:Adult; D004381:Duodenal Ulcer / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007275:Injections, Intravenous; D007376:Interleukin-2 / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000187:drug effects; D007958:Leukocyte Count / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D011971:Receptors, Immunologic / Q000096:biosynthesis; D015375:Receptors, Interleukin-2; D013268:Stimulation, Chemical; D013601:T-Lymphocytes / Q000145:classification / Q000187:drug effects
D007376:Interleukin-2; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D011433:Propranolol