Immunopathogenesis of HIV infection.
HIV may cause CD4-positive T cell depletion not only by direct infection but by causing damage to normal maintenance mechanisms. Findings in support of such a concept are presented. Results suggesting that immune reactions against HIV may contain elements of a negative nature are presented, in particular in relation to viral enhancement by antibodies. A question is also raised whether HIV replication has been proved to be reduced in a significant manner by immune reactions.
Wigzell
H
H
Department of Immunology, Karolinska Institute, Stockholm, Sweden.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000276:Adjuvants, Immunologic; D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies / Q000276:immunology; D006801:Humans; D009000:Monocytes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014779:Virus Replication
D000276:Adjuvants, Immunologic; D000945:Antigens, Differentiation, T-Lymphocyte; D015483:HIV Antibodies