Triiodothyronine increases serum angiotensin converting enzyme.
To determine whether elevated thyroid hormone is responsible for increased serum angiotensin converting enzyme in hyperthyroidism, 5 to 40 micrograms of 3,5,3'-triiodo-L-thyronine was administered orally and subcutaneously to female Swiss-Webster mice. Serum angiotensin converting enzyme was significantly increased in all animals given triiodothyronine compared to controls. Lung and kidney enzymes were moderately reduced in specific activity but unchanged in total activity due to increase in size of these organs. The results indicate that in hyperthyroidism, elevated thyroid hormone per se rather than the disease of the thyroid is responsible for elevated serum angiotensin converting enzyme.
Silverstein
E
E
Schussler
G C
GC
Friedland
J
J
D000818:Animals; D007668:Kidney / Q000201:enzymology; D008168:Lung / Q000201:enzymology; D051379:Mice; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D007703:Peptidyl-Dipeptidase A