Coronary angioplasty for acute myocardial infarction.
OBJECTIVE
To critically review the role of coronary angioplasty for acute myocardial infarction.


METHODS
Studies published from January 1982 to June 1988 were identified through a search of the English-language literature using MEDLINE and thorough extensive hand searching of bibliographies of identified articles.


METHODS
All consecutive patient series and randomized trials of coronary angioplasty for acute myocardial infarction.


METHODS
Demographic characteristics, technical results, clinical outcomes, and left ventricular function results were collated.


RESULTS
Three randomized trials have compared immediate and deferred coronary angioplasty after intravenous tissue plasminogen activator. Immediate angioplasty was associated with increased mortality, increased need for emergency bypass surgery, higher transfusion requirement, and no benefit in terms of left ventricular functional recovery.


CONCLUSIONS
The role of coronary angioplasty for myocardial infarction has thus far been established as adjunctive, in a delayed time frame after thrombolytic therapy. Coronary angioplasty has not been shown to reduce in-hospital mortality or improve resting left ventricular function. A deferred strategy has improved exercise left ventricular performance, and several follow-up studies suggest a favorable long-term prognosis.
Topol
E J
EJ
University of Michigan, Ann Arbor.
D000800:Angioplasty, Balloon / Q000009:adverse effects / Q000379:methods*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003331:Coronary Vessels / Q000473:pathology; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D049673:History, 20th Century; D006801:Humans; D007269:Injections, Intra-Arterial; D009203:Myocardial Infarction / Q000266:history / Q000628:therapy*; D013997:Time Factors
D005343:Fibrinolytic Agents