Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.
We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor alpha-subunit, a precursor processing enzyme cleavage site, then the beta-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.
Ullrich
A
A
Bell
J R
JR
Chen
E Y
EY
Herrera
R
R
Petruzzelli
L M
LM
Dull
T J
TJ
Gray
A
A
Coussens
L
L
Liao
Y C
YC
Tsubokawa
M
M
D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D066246:ErbB Receptors; D005796:Genes; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D008970:Molecular Weight; D009857:Oncogenes; D011487:Protein Conformation; D011494:Protein Kinases / Q000235:genetics*; D011505:Protein-Tyrosine Kinases; D012333:RNA, Messenger / Q000235:genetics; D011972:Receptor, Insulin / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics
D008565:Membrane Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D004247:DNA; D011494:Protein Kinases; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases; D011972:Receptor, Insulin