Vitamin E and Alzheimer's disease in subjects with Down's syndrome.
People with Down's syndrome (DS) are at high risk of developing Alzheimer's disease (AD). The gene coding for superoxide dismutase-/ on chromosome 21 resulting in excess activity of the enzyme with consequent risk of oxidative damage might account for the premature ageing. Vitamin E protects against such damage. Plasma vitamin E levels measured in 12 DS subjects with AD (8.19 +/- 0.77 micrograms/ml) were lower (P less than 0.05) than in 12 DS controls (9.43 +/- 1.57 micrograms/ml). It is suggested that there may be an interaction between risk of AD and the protective action of vitamin E.
Jackson
C V
CV
Department of Biochemistry, University of Surrey, Guildford, Surrey, England.
Holland
A J
AJ
Williams
C A
CA
Dickerson
J W
JW
D000328:Adult; D000544:Alzheimer Disease / Q000097:blood*; D004314:Down Syndrome / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014810:Vitamin E / Q000097:blood*; D014811:Vitamin E Deficiency / Q000097:blood
D014810:Vitamin E