Inability to detect a K cell in bovine peripheral blood leukocytes.
Antibody-dependent cellular cytotoxicity to viral-infected cells, chicken red blood cells, and tumor cells was tested using different effector cell populations: polymorphonuclear cells, mononuclear cells, and mononuclear cells separated into adherent and nonadherent populations by Sephadex G-10. Polymorphonuclear cells were the most efficient mediators of antibody-dependent cellular cytotoxicity against most targets, although a combination of G-10 adherent and polymorphonuclear cells was more efficient in killing infectious bovine rhinotracheitis virus-infected cells than either single cell population. Removal of G-10 adherent cells from the mononuclear cell population removed all antibody-dependent cellular cytotoxicity from that population, indicating the lack of a typical K cell in bovine peripheral blood.
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D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002417:Cattle / Q000276:immunology*; D002448:Cell Adhesion; D002460:Cell Line; D002645:Chickens; D003601:Cytotoxicity Tests, Immunologic; D001908:Diarrhea Viruses, Bovine Viral / Q000254:growth & development; D004912:Erythrocytes / Q000276:immunology; D007242:Herpesvirus 1, Bovine / Q000254:growth & development; D006801:Humans; D007668:Kidney; D007694:Killer Cells, Natural / Q000276:immunology*; D008168:Lung; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D009000:Monocytes / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D010224:Parainfluenza Virus 3, Human / Q000254:growth & development; D013737:Testis