[Inhibition of the function of the neutrophil granulocyte caused by autologous serum from patients with acne vulgaris].
Sixteen patients with acne vulgaris were studied. All patients had severe inflammatory lesions, nodulocystic and conglobata. Of them, 12 was male and 4 female, their age was between 16 and 24 years old. In all the cases laboratory test to evaluate chemotactic, nitroblue-tetrazolium and lysosomal activity of granulocyte were performed. The protocol included in vitro incubations with and without autologous serum for considered their action on the phagocytic cell. The results shows an inhibitory action of the autologous serum in chemotactic (d-mean, 34.25%; SEM, 2.39, p less than 0.01), nitroblue-tetrazolium test (d-mean, 21.06%; SEM, 2.85, p less than 0.05), and lysosomal activity (d-mean, 21.43%; SEM, 2.80, p less than 0.05). The authors suggest that granulocyte alterations that occur in inflammatory forms of acne vulgaris is a secondary phenomenon may be caused by seric IgE or vasoactive substances released during immune responses.
Vignale
R
R
Facultad de Medicina, Hospital de Clínicas Doctor Manuel Quintela, Montevideo, Uruguay.
Lasalvia
E
E
Paciel
J
J
D000152:Acne Vulgaris / Q000097:blood*; D000293:Adolescent; D000328:Adult; D002634:Chemotaxis, Leukocyte; D005260:Female; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000502:physiology*
Inhibición de la función del granulocito neutrófilo por suero autólogo procedente de pacientes con acné vulgar.