The importance of the striato-nigro-collicular pathway in the expression of haloperidol-induced tonic electromyographic activity.
Experiments were carried out to investigate the participation of the striatonigral and nigrocollicular GABAergic pathways in the expression of haloperidol-induced tonic electromyographic (EMG) activity of the gastrocnemius-soleus muscle in awake rats. It was shown that bilateral injections of haloperidol (500 ng/0.5 microliter) into the rostral part of the neostriatum induced a tonic EMG activity which could be significantly reduced by a second bilateral injection of muscimol (25 ng/0.5 microliter) into the substantia nigra pars reticulata (SNR) or of bicuculline (50 ng/0.5 microliter) into the intermediate or deep layers of the colliculus superior (CS). These results suggest that the striatonigral and nigrocollicular GABAergic pathways play a critical role in the transmission of haloperidol-induced tonic EMG activity.
Ellenbroek
B
B
Schwarz
M
M
Sontag
K H
KH
Cools
A
A
D000818:Animals; D001931:Brain Mapping; D003342:Corpus Striatum / Q000187:drug effects*; D004576:Electromyography; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009127:Muscle Rigidity / Q000139:chemically induced* / Q000503:physiopathology; D009132:Muscles / Q000503:physiopathology; D009434:Neural Pathways / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000503:physiopathology*; D013477:Superior Colliculi / Q000503:physiopathology*; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D005680:gamma-Aminobutyric Acid; D006220:Haloperidol