Mirex-induced liver enlargement in rats is dependent upon an intact pituitary-adrenalcortical axis.
The effect of prior hypophysectomy upon mirex-induced liver hypertrophy in male Sprague-Dawley rats was examined. Mirex had no effect upon adrenal weight, liver weight, plasma glucose or plasma corticosterone in hypophysectomized rats. However, daily corticosterone supplements (20 mg/kg body weight, sc) given to mirex-treated hypophysectomized animals yielded a 52% increase in liver weight to body weight ratios over those observed in mirex-treated hypophysectomized animals not receiving supplement. In intact rats, both liver weight to body weight ratios and plasma ACTH were significantly increased over controls 2 days after mirex treatment. These results indicate that mirex-induced liver enlargement not only requires corticosterone, but that the response is dependent upon an intact pituitary-adrenalcortical axis.
Ervin
M G
MG
Yarbrough
J D
JD
D000302:Adrenal Cortex / Q000502:physiology*; D000311:Adrenal Glands / Q000033:anatomy & histology; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology; D007016:Hypophysectomy; D007306:Insecticides / Q000494:pharmacology*; D008099:Liver / Q000033:anatomy & histology*; D008297:Male; D008917:Mirex / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D007306:Insecticides; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone; D008917:Mirex