Lithium effects on position learning with exploratory and aversive goal-box conditions.
Under conflict conditions in which reinforcement occurred within mildly aversive white goal-boxes, the chronic administration of lithium chloride (20 meg/l, in drinking water) to rats, while reducing avoidance of the goal boxes, impaired acquisition of an exploration-reinforced position discrimination. These results were interpreted as supporting the concept that lithium salts reduce the individual's reaction to general environmental stimulation--an effect which may account for its therapeutic action in the treatment of manic disorders.
Hines
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D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002712:Chlorides / Q000494:pharmacology*; D004777:Environment; D005106:Exploratory Behavior / Q000187:drug effects; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D008297:Male; D051381:Rats
D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride