3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims.
An excess of the tryptophan metabolite quinolinic acid in the brain has been hypothetically related to the pathogenesis of Huntington disease. Quinolinate's immediate biosynthetic enzyme, 3-hydroxyanthranilate oxygenase (EC 1.13.11.6), has now been detected in human brain tissue. The activity of 3-hydroxyanthranilate oxygenase is increased in Huntington disease brains as compared to control brains. The increment is particularly pronounced in the striatum, which is known to exhibit the most prominent nerve-cell loss in Huntington disease. Thus, the Huntington disease brain has a disproportionately high capability to produce the endogenous "excitotoxin" quinolinic acid. This finding may be of relevance for clinical, neuropathologic, and biochemical features associated with Huntington disease.
Schwarcz
R
R
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228.
Okuno
E
E
White
R J
RJ
Bird
E D
ED
Whetsell
W O
WO
D050561:3-Hydroxyanthranilate 3,4-Dioxygenase; D001921:Brain / Q000201:enzymology*; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000201:enzymology; D049308:Dioxygenases; D006801:Humans; D006816:Huntington Disease / Q000201:enzymology*; D007700:Kinetics; D010105:Oxygenases / Q000378:metabolism*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000378:metabolism
D011805:Quinolinic Acids; D010105:Oxygenases; D049308:Dioxygenases; D050561:3-Hydroxyanthranilate 3,4-Dioxygenase; D017378:Quinolinic Acid