Parallel changes in the sensitivity of gamma-aminobutyric acid and noradrenergic receptors following chronic administration of antidepressant and GABAergic drugs. A possible role in affective disorders.
Chronic treatment with the antidepressants imipramine or nomifensine, or the gamma-aminobutyric acid (GABAergic) agents, baclofen or THIP, produced a decrease in the Bmax for binding sites of GABAergic and noradrenergic receptors. Chronic treatment with imipramine or nomifensine produced a decrease in the Bmax of both binding of [3H]dihydroalprenolol and [3H]GABA receptors in the cerebral cortex and hippocampus. Chronic treatment with baclofen or THIP also produced a decrease in the Bmax of binding of [3H]dihydroalprenolol receptor in the cerebral cortex and hippocampus. These results suggest a possible link between the GABAergic and noradrenergic systems, which may be important in understanding the mechanism of action of antidepressant drugs, and suggests a possible role for GABA in affective disorders.
Suzdak
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PD
Gianutsos
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G
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D000928:Antidepressive Agents / Q000494:pharmacology*; D001418:Baclofen / Q000494:pharmacology; D002540:Cerebral Cortex / Q000378:metabolism; D004082:Dihydroalprenolol / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D007099:Imipramine / Q000494:pharmacology; D007555:Isoxazoles / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D051379:Mice; D019964:Mood Disorders / Q000503:physiopathology; D009627:Nomifensine / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects* / Q000378:metabolism; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000927:Anticonvulsants; D000928:Antidepressive Agents; D007555:Isoxazoles; D011941:Receptors, Adrenergic; D011963:Receptors, GABA-A; D009627:Nomifensine; D005680:gamma-Aminobutyric Acid; D004082:Dihydroalprenolol; D001418:Baclofen; C015542:gaboxadol; D007099:Imipramine