title: Age-related reductions in rat atrial high affinity choline uptake, ACh synthesis, and ACh release. A brief note.
abstract: We have developed a rat atrial mince preparation that can take up choline, acetylate it, and then release acetylcholine in a depolarization-dependent manner. We demonstrate that aging appears to reduce the functional cholinergic activity in this tissue, which may be important for understanding how senescence alters the regulation of cardiac activity.
authors.forename: E M
authors.initials: EM
authors.lastname: Meyer
authors.forename: A
authors.initials: A
authors.lastname: Esen Momol
authors.forename: S P
authors.initials: SP
authors.lastname: Baker
mesh_terms: D000109:Acetylcholine / Q000096:biosynthesis*; D000375:Aging; D000818:Animals; D002794:Choline / Q000378:metabolism*; D006325:Heart Atria / Q000378:metabolism; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D009435:Synaptic Transmission
chemical_list: D002794:Choline; D000109:Acetylcholine