title: Isolation of lymphadenopathy-associated virus (LAV) and detection of LAV antibodies from US patients with AIDS.
abstract: A human retrovirus was isolated from the peripheral blood of three American patients newly diagnosed with the acquired immunodeficiency syndrome (AIDS). In each case the major core viral protein (p25) was shown to be antigenically identical to that of the prototype lymphadenopathy-associated virus (LAV). Two of the viral isolates were derived from intravenous narcotics abusers, the first demonstration of LAV isolation from this risk group. Antibody to LAV was detected by an IgG enzyme-linked immunosorbent assay in the serum samples of these and 14 additional American patients with AIDS and in none of 12 hospital worker controls. These findings provide support for the etiologic association of LAV and AIDS.
authors.forename: F
authors.initials: F
authors.lastname: Barré-Sinoussi
authors.forename: U
authors.initials: U
authors.lastname: Mathur-Wagh
authors.forename: F
authors.initials: F
authors.lastname: Rey
authors.forename: F
authors.initials: F
authors.lastname: Brun-Vezinet
authors.forename: S R
authors.initials: SR
authors.lastname: Yancovitz
authors.forename: C
authors.initials: C
authors.lastname: Rouzioux
authors.forename: L
authors.initials: L
authors.lastname: Montagnier
authors.forename: D
authors.initials: D
authors.lastname: Mildvan
authors.forename: J C
authors.initials: JC
authors.lastname: Chermann
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000382:microbiology*; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D017977:Deltaretrovirus / Q000276:immunology / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008715:Methionine; D008875:Middle Aged; D010564:Personnel, Hospital; D013462:Sulfur Radioisotopes; D013601:T-Lymphocytes / Q000382:microbiology; D014481:United States; D014776:Virus Cultivation
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D013462:Sulfur Radioisotopes; D008715:Methionine