Theophylline prolongs survival and decreases renal damage in female NZB/W F-1 mice.
Theophylline (Th) augments suppressor T cell activity (STCA). We attempted to test this immunoregulatory effect of TH on survival, renal disease and several immunologic parameters in NZB/W F-1 female mice. The median survival was 274 +/- 50 days for the mice receiving Th and 235 +/- 39 days for the controls (p less than 0.01). Assessment of the extent of renal damage by light microscopy revealed activity scores of 1.86 +/- 2 and 4.71 +/- 2.7 for the Th and control groups, respectively (p less than 0.001). T cell activity of NZB/W F-1 lymphocytes was assessed by the local xenogeneic GVH reaction. The mean GVH reaction volume of the Th group was significantly lower (9.3 +/- 8.8 mm3) as compared to controls (31 +/- 9 mm3) (p less than 0.001). The proportion of Lyt-1 versus Lyt-2 spleen lymphocytes did not change significantly. It is concluded that Th prolongs survival and decreases the extent of renal damage in female NZB/W F-1 mice.
Gelber
M
M
Department of Internal Medicine, D. Beilinson Medical Center, Petah Tiqva, Israel.
Sidi
Y
Y
Ben-Bassat
M
M
Shohat
B
B
Pinkhas
J
J
Weinberger
A
A
D000818:Animals; D000974:Antibodies, Antinuclear / Q000096:biosynthesis; D004195:Disease Models, Animal; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D006087:Graft vs Host Reaction / Q000187:drug effects; D007105:Immune Complex Diseases / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000276:immunology; D051379:Mice; D008814:Mice, Inbred NZB; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology; D013806:Theophylline / Q000627:therapeutic use*
D000974:Antibodies, Antinuclear; D013806:Theophylline