Immunostimulatory function of herpes simplex virus isolates from patients with frequent herpes labialis and a deficiency in immune-specific interferon production.
Approximately 30% of persons with frequent episodes of herpes labialis are deficient in the production of HSV-induced immune-specific interferon (IFN) (Green, 1985). Herpes simplex virus (HSV) strains isolated from persons who make immune-specific IFN and from persons who do not make it were examined for their immunostimulatory capabilities. HSV isolated from the primary oral lesions of two patients deficient in immune-specific IFN production, one person with an intact immune-specific IFN response, HSV types 1 and 2 laboratory strains, and Newcastle disease virus (NDV) were added to cultures of peripheral blood mononuclear cells (PBML) from HSV seropositive donors. All HSV-isolates induced comparable titers of immune-specific IFN. These studies suggest that failure of some patients to develop an immune-specific IFN response is determined by the host, not the virus.
Klieman
R L
RL
Green
J A
JA
Spruance
S L
SL
D000818:Animals; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D005347:Fibroblasts; D006560:Herpes Labialis / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis / Q000172:deficiency*; D007371:Interferon-gamma / Q000096:biosynthesis / Q000172:deficiency*; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008907:Mink; D012008:Recurrence; D018139:Simplexvirus / Q000276:immunology* / Q000302:isolation & purification; D014776:Virus Cultivation; D014779:Virus Replication
D007370:Interferon Type I; D007371:Interferon-gamma