Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes.
The c-mos proto-oncogene is expressed as a maternal mRNA in oocytes and early embryos of Xenopus laevis, but its translation product pp39mos is detectable only during progesterone-induced oocyte maturation. Microinjection of mos-specific antisense oligonucleotides into oocytes not only prevents expression of pp39mos, but also blocks germinal vesicle breakdown, indicating that it functions during reinitiation of meiotic division.
Sagata
N
N
Bionetics Research Inc., National Cancer Institute, Frederick, Maryland 21701.
Oskarsson
M
M
Copeland
T
T
Brumbaugh
J
J
Vande Woude
G F
GF
D000818:Animals; D001483:Base Sequence; D004247:DNA; D005260:Female; D008540:Meiosis; D008938:Mitosis; D008969:Molecular Sequence Data; D009857:Oncogenes; D009865:Oocytes / Q000254:growth & development*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D017231:Proto-Oncogene Proteins c-mos; D014981:Xenopus / Q000196:embryology*
D011518:Proto-Oncogene Proteins; D004247:DNA; D017231:Proto-Oncogene Proteins c-mos