Measurement of hypothalamic corticotropin-releasing factors in hypophyseal portal blood.
Among the putative hypothalamic hormones that can influence the release of adrenocorticotropin (ACTH) in vitro, the 41-amino-acid corticotropin-releasing factor, oxytocin, vasopressin, and epinephrine were identified in hypophyseal portal plasma. Measurement of these substances in several situations associated with changes in ACTH secretion provided data consistent with a physiological role for all four hormones and suggested that control of the hypothalamo-hypophyseal-adrenal axis can be accomplished in different ways in response to different types of stimuli.
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D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D003346:Corticotropin-Releasing Hormone / Q000097:blood*; D005473:Fluoxetine / Q000494:pharmacology; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D010121:Oxytocin / Q000097:blood; D010902:Pituitary Gland / Q000098:blood supply*; D051381:Rats; D012701:Serotonin / Q000502:physiology
D005473:Fluoxetine; D001127:Arginine Vasopressin; D012701:Serotonin; D010121:Oxytocin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone