Cardiopulmonary effects of celiprolol and bisoprolol in serotonin-infused cats.
The effects of celiprolol and bisoprolol on cardiopulmonary function in serotonin-infused cats were compared. Celiprolol reversed the bronchoconstrictive effect of serotonin at doses greater than or equal to 1.0 mg/kg. Also, decreases in mean arterial pressure and heart rate were noted after administration of 3-10 and 10 mg/kg celiprolol, respectively. In contrast, bisoprolol tended to induce bronchoconstriction. Reductions in mean arterial pressure and heart rate were observed with 1 or 3 mg/kg. Bisoprolol administration at 10 mg/kg was lethal. The unique ability of celiprolol to induce bronchodilation enhances its therapeutic potential.
Carnathan
G W
GW
Rorer Central Research, Department of Immunobiology, Horsham, PA 19044.
Sweeney
D M
DM
Gordon
R
R
Pruss
T P
TP
D000818:Animals; D000959:Antihypertensive Agents; D017298:Bisoprolol; D001794:Blood Pressure / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects; D001993:Bronchodilator Agents; D002415:Cats; D017272:Celiprolol; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011412:Propanolamines / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology
D000959:Antihypertensive Agents; D001993:Bronchodilator Agents; D011412:Propanolamines; D012701:Serotonin; D017272:Celiprolol; D017298:Bisoprolol