[Passage into the human milk and clinical evaluation of sulbactam/cefoperazone].
A combined agent of sulbactam, a beta-lactamase inhibitor, plus cefoperazone (SBT/CPZ: 1/1) was studied on the passage into the maternal milk as well on the clinical application and the results were followings: One or 2 grams of SBT/CPZ was given by one shot intravenous injection to puerperal mothers to determine the passage into the milk up to 6 hours after the administration. A trace of passage was detected for both SBT and CPZ as in the case of other antibiotics. Good clinical efficacy was observed in all 5 patients with female genital organ infections, to whom a daily dose of 2.0 g of SBT/CPZ was administered by drip infusion for 4 to 6 days. No side effects were noticed.
Matsuda
S
S
Kashiwagura
T
T
Hirayama
H
H
D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy*; D002438:Cefoperazone / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy*; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D008895:Milk, Human / Q000378:metabolism*; D010397:Penicillanic Acid / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D011247:Pregnancy; D013407:Sulbactam; D065093:beta-Lactamase Inhibitors
D004338:Drug Combinations; D065093:beta-Lactamase Inhibitors; D002438:Cefoperazone; D010397:Penicillanic Acid; D013407:Sulbactam