title: [Pharmacokinetics of ceftazidime in healthy and renal failure subjects].
abstract: Ceftazidime is poorly bound to plasma proteins, is not metabolized and is excreted mostly by glomerular filtration. Its elimination half-life is about 1.5-2 hours, and their kinetics are modified by renal impairment. The dosage recommended in adult is 1 to 2 g 8-hourly, to be adjusted to the needs of individual cases. The interval between doses must be extended to 12 hours in patients with mild renal impairment and to 36-48 hours in those with severe renal failure. A supplementary dose of ceftazidime is required at the end of each haemodialysis session. In patients under chronic peritoneal dialysis, the loading dose (10 mg/kg) is followed by continuous administration of 5 mg/kg into each dialysis cavity.
authors.affiliation: Hôpital Charles-Nicolle, Rouen.
authors.forename: A
authors.initials: A
authors.lastname: Leroy
authors.forename: J P
authors.initials: JP
authors.lastname: Fillastre
authors.forename: G
authors.initials: G
authors.lastname: Humbert
authors.forename: F
authors.initials: F
authors.lastname: Borsa
authors.forename: F
authors.initials: F
authors.lastname: Leguy
authors.forename: G R
authors.initials: GR
authors.lastname: Spencer
mesh_terms: D002442:Ceftazidime / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007676:Kidney Failure, Chronic / Q000097:blood*; D006435:Renal Dialysis
chemical_list: D002442:Ceftazidime
vernacular_title: Pharmacocinétique de la ceftazidime chez le sujet sain et chez l'insuffisant rénal.