Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro.
Human small cell lung carcinoma (SCLC) cells have been shown to contain significant levels of a bombesin-immunoreactive peptide. The 27-amino acid peptide, gastrin releasing peptide (GRP), has recently been shown to be responsible for the bombesin-like immunoreactivity found in SCLC cells. Among four lung cancer cell lines examined in vitro, GRP exhibited mitogenic activity for two SCLC subtypes, but not for a squamous carcinoma or adenocarcinoma lung cell line. The mitogenicity of the GRP molecule has been isolated to the carboxyterminal fragment, designated GRP 14-27, which is in part homologous to bombesin. The aminoterminal fragment, GRP 1-16, is no homologous to bombesin and exhibits no mitogenic activity. Thus, GRP may be an important growth regulating or autocrine factor in human SCLC.
Weber
S
S
Zuckerman
J E
JE
Bostwick
D G
DG
Bensch
K G
KG
Sikic
B I
BI
Raffin
T A
TA
D018288:Carcinoma, Small Cell / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D002452:Cell Count; D019886:Gastrin-Releasing Peptide; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008934:Mitogens; D010455:Peptides / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D008934:Mitogens; D010455:Peptides; D014316:Tritium; D019886:Gastrin-Releasing Peptide; D013936:Thymidine