Inhibitory effect of brain natriuretic peptide on central angiotensin II-stimulated pressor response in conscious rats.
The effect of intracerebroventricular injection of brain natriuretic peptide (BNP) on blood pressure and heart rate was studied in conscious, unrestrained rats. The intracerebroventricular (i.c.v.) injection of BNP did not affect basal blood pressure and heart rate, but it attenuated i.c.v. angiotensin II (AII)-induced pressor response in a dose-dependent manner. These results suggest that BNP plays a role in the regulation of blood pressure in the central nervous system.
Shirakami
G
G
Department of Medicine, Kyoto University School of Medicine, Japan.
Nakao
K
K
Yamada
T
T
Itoh
H
H
Mori
K
K
Kangawa
K
K
Minamino
N
N
Matsuo
H
H
Imura
H
H
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000804:Angiotensin II; D009320:Atrial Natriuretic Factor