Atrial natriuretic factor in experimental and human hypertension.
Plasma levels of immunoreactive atrial natriuretic factor (IR-ANF) were evaluated by radioimmunoassay in several models of experimental hypertension and in human hypertension. Plasma levels of IR-ANF are consistently increased in all models of experimental hypertension studied so far. This is accompanied by a decrease of IR-ANF levels in the left atrium at certain times. Plasma levels of IR-ANF are not increased in human essential hypertension, except in the severe form (diastolic blood pressure above 110 mmHg). Peripheral levels of IR-ANF in renovascular hypertension do not differ from normal but are increased above normal in aortic blood.
Cantin
M
M
Clinical Research Institute of Montreal, Quebec, Canada.
Garcia
R
R
Thibault
G
G
Kuchel
O
O
Gutkowska
J
J
Larochelle
P
P
Hamet
P
P
Schiffrin
E L
EL
Genest
J
J
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000032:analysis* / Q000502:physiology / Q000627:therapeutic use; D005260:Female; D006325:Heart Atria / Q000032:analysis; D006352:Heart Ventricles / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D006977:Hypertension, Renal / Q000378:metabolism; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY
C472955:NPPA protein, human; D009320:Atrial Natriuretic Factor