An outbreak of coxsackievirus B infection followed by one case of diabetes mellitus.
During the fall of 1979, 22/250 Swedish UN soldiers serving in Egypt were hospitalized with fever and gastroenteritis associated with aseptic meningitis. One of the 22 developed insulin dependent diabetes mellitus (IDDM) 10 weeks following the infection. The majority of the 22 patients showed significant titer rise for coxsackievirus B by plaque reduction neutralization test. The serology results indicate that coxsackievirus B4 most likely caused the outbreak. All 22 were also tested for islet cell cytoplasmic antibodies and islet cell surface antibodies and found negative. The individual developing diabetes mellitus had the HLA-DR phenotype 3,4, which is associated with IDDM.
Niklasson
B S
BS
Dobersen
M J
MJ
Peters
C J
CJ
Ennis
W H
WH
Möller
E
E
D000328:Adult; D003384:Coxsackievirus Infections / Q000150:complications* / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000235:genetics; D004196:Disease Outbreaks; D004198:Disease Susceptibility; D004534:Egypt; D029822:Enterovirus B, Human; D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II; D006801:Humans; D008297:Male; D008887:Military Medicine; D013548:Sweden / Q000208:ethnology
D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II