Hypo- and hyperdiploidy in cultured amniocytes.
2,340 metaphases of amniocytes from 149 karyotypically normal women were analyzed for hypo- and hyperdiploidy. Hypodiploidy was more frequent than hyperdiploidy. Chromosome loss was correlated with size. The smaller chromosomes are lost more frequently (r = 0.62 p less than 0.05) than the larger ones. Considering the inconclusive findings of lymphocyte cultures, one can conclude that the hypodiploid cells arose as technical artifacts while hyperdiploidy may be due to somatic non-disjunction owing to pseudomosaicism.
Powell
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Division of Genetics, Long Island College Hospital, Brooklyn, New York 11201.
Verma
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D000328:Adult; D000650:Amnion / Q000166:cytology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004171:Diploidy; D005260:Female; D006801:Humans; D008297:Male; D008423:Maternal Age; D008677:Metaphase; D011003:Ploidies; D011247:Pregnancy; D018566:Pregnancy, High-Risk