title: Incomplete redistribution in delayed thallium-201 single photon emission computed tomographic (SPECT) images: an overestimation of myocardial scarring.
abstract: To determine if incomplete redistribution at 4 h in exercise tomographic thallium-201 studies is always due to a myocardial scar, 141 patients were evaluated before and after a total of 160 successful percutaneous transluminal coronary angioplasty procedures. Thallium studies were analyzed using polar "bull's-eye" maps. For both immediate and delayed images, abnormalities were quantified as a thallium score by calculating a standard deviation-weighted sum of pixels greater than 2.5 SD below gender-matched normal limits. One hundred forty-four of 160 studies indicated abnormalities before angioplasty. Of these 144, incomplete redistribution occurred in 111 (77%): 16 (14%) in patients with and 95 (86%) in patients without prior Q wave myocardial infarction. After angioplasty, improvement in delayed image score occurred in 8 (50%) of 16 patients with prior infarction and 72 (76%) of 95 patients without prior infarction (p less than 0.05). After angioplasty, delayed images were normal in 1 (6%) of 16 patients with prior infarction and 32 (34%) of the 95 without (p less than 0.05). Before angioplasty, delayed image scores were positively correlated with scores in the immediate postexercise images in patients with (r = 0.84) and those without (r = 0.69) prior infarction. To determine if additional delayed images could help differentiate scar from ischemia, an 8 to 24 h delayed image was obtained in each of 40 other patients with incomplete redistribution at 4 h. Of 28 patients without prior infarction, 15 had no redistribution, and 13 had further redistribution at 8 to 24 h.
authors.affiliation: Department of Radiology, Emory University School of Medicine, Atlanta, Georgia 30322.
authors.forename: K G
authors.initials: KG
authors.lastname: Cloninger
authors.forename: E G
authors.initials: EG
authors.lastname: DePuey
authors.forename: E V
authors.initials: EV
authors.lastname: Garcia
authors.forename: G S
authors.initials: GS
authors.lastname: Roubin
authors.forename: W L
authors.initials: WL
authors.lastname: Robbins
authors.forename: A
authors.initials: A
authors.lastname: Nody
authors.forename: E E
authors.initials: EE
authors.lastname: DePasquale
authors.forename: H J
authors.initials: HJ
authors.lastname: Berger
mesh_terms: D000328:Adult; D000368:Aged; D000800:Angioplasty, Balloon; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000628:therapy; D002921:Cicatrix / Q000000981:diagnostic imaging*; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging; D013794:Thallium Radioisotopes; D013997:Time Factors; D014055:Tomography, Emission-Computed
chemical_list: D013794:Thallium Radioisotopes