Presence of the adenovirus E1A-like activity in preimplantation stage mouse embryos.
The presence of the adenovirus E1A-like activity in embryonal carcinoma stem cells has been reported. We now show that preimplantation stage mouse embryonic cells allow transcription of the E1A-dependent E2A gene when infected with E1A-deleted mutant dl312, indicating the presence of the E1A-like activity in morulae and blastocysts. Moreover, such activity seems to decrease or disappear at about the time of implantation.
Suemori
H
H
Division of Developmental Biology, Meiji Institute of Health Science, Odawara, Japan.
Hashimoto
S
S
Nakatsuji
N
N
D017456:Adenovirus Early Proteins; D000818:Animals; D000957:Antigens, Viral, Tumor / Q000235:genetics*; D001755:Blastocyst / Q000166:cytology / Q000382:microbiology*; D002970:Cleavage Stage, Ovum / Q000382:microbiology*; D005260:Female; D005455:Fluorescent Antibody Technique; D051379:Mice; D008813:Mice, Inbred ICR; D009028:Morula / Q000166:cytology / Q000382:microbiology*; D009856:Oncogene Proteins, Viral / Q000032:analysis / Q000235:genetics*; D013480:Superovulation
D017456:Adenovirus Early Proteins; D000957:Antigens, Viral, Tumor; D009856:Oncogene Proteins, Viral