Rib cage and abdominal expiratory muscle responses to CO2 and esophageal distension.
The present study compared the responses of rib cage and abdominal expiratory muscles to chemical and mechanical stimuli. In pentobarbital-anesthetized spontaneously breathing dogs, electromyograms (EMG) were recorded from the triangularis sterni (TS) and transverse abdominis (TA) muscles using bipolar intramuscular wire electrodes. During resting oxygen breathing, both muscles were electrically active during expiration. Progressive hyperoxic hypercapnia significantly augmented the expiratory activity of both the TA and the TS. However, the mean percent increases in electrical activity in response to CO2 were substantially greater for the TA than for the TS at all PCO2 levels greater than 50 Torr (P less than 0.01). Occlusion of the airway at end inspiration significantly delayed the onset of TS EMG (from 0.35 +/- 0.07 to 3.35 +/- 0.67 sec; P less than 0.002) and decreased TS EMG rate of rise (P less than 0.002), but did not significantly alter these parameters for the TA. Esophageal distension increased TS EMG in all dogs (by mean of 220 +/- 64%; P less than 0.01), but in contrast decreased TA EMG in all dogs (by a mean of 63 +/- 12%; P less than 0.001). The response to esophageal distention occurred in a graded manner and appeared to be mediated predominantly via vagal afferents. We concluded that expiratory muscles of the rib cage and abdomen manifest substantial differences in their electrical responses to chemoreceptor, pulmonary stretch receptor, and esophageal mechanoreceptor stimuli.(ABSTRACT TRUNCATED AT 250 WORDS)
van Lunteren
E
E
Department of Medicine, University Hospitals of Cleveland, Ohio.
Haxhiu
M A
MA
Cherniack
N S
NS
Arnold
J S
JS
D000009:Abdominal Muscles / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology*; D004285:Dogs; D004576:Electromyography; D004947:Esophagus / Q000502:physiology*; D008465:Mechanoreceptors / Q000502:physiology; D010812:Physical Stimulation; D012119:Respiration; D012132:Respiratory Muscles / Q000187:drug effects / Q000502:physiology*
D002245:Carbon Dioxide