A second nuclear protein is encoded by Epstein-Barr virus in latent infection.
A region of the Epstein-Barr virus (EBV) genome that is important in inducing cell proliferation includes a single long open reading frame. Part of this open reading frame has been fused to the lacZ gene and expressed in Escherichia coli. Antisera to the fusion protein identify a protein in the nuclei of latently infected growth-transformed lymphocytes and in Burkitt tumor cells grown in vitro. This nuclear protein is encoded by a different virus-gene than that which encodes the previously described EBV nuclear antigen, EBNA.
Hennessy
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Kieff
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D000818:Animals; D000956:Antigens, Viral / Q000235:genetics; D002051:Burkitt Lymphoma / Q000235:genetics / Q000382:microbiology; D002467:Cell Nucleus / Q000378:metabolism; D002472:Cell Transformation, Viral; D019309:Epstein-Barr Virus Nuclear Antigens; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology; D011817:Rabbits / Q000276:immunology; D014764:Viral Proteins / Q000235:genetics*
D000956:Antigens, Viral; D019309:Epstein-Barr Virus Nuclear Antigens; D014764:Viral Proteins