Efficacy of low-dose Aracytine in 3 cases of refractory anemia in transformation in children.
A treatment with cytosine arabinoside in low doses is administered to 3 children affected by refractory anemia with myeloblast in transformation. The remission is obtained in 3 cases. One child relapsed at 24 months. The other 2 children are in persistent remission at 40 and 48 months. This relatively non-aggressive mode of treatment seems to have a place in children affected by myelodysplasia and for whom allografting from an HLA-identical donor is not available.
Reman
O
O
Service d'Hématologie Clinique, CHU de Caen, France.
Boutard
P
P
Guihard
J
J
D000753:Anemia, Refractory / Q000150:complications / Q000188:drug therapy*; D002675:Child, Preschool; D003561:Cytarabine / Q000627:therapeutic use*; D004314:Down Syndrome / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D012074:Remission Induction
D003561:Cytarabine