title: The chemical synthesis and antiviral properties of an acyclovir-phospholipid conjugate.
abstract: The synthesis of acyclovir-phospholipid conjugate (2) is reported through an unambiguous one-step preparation of L-alpha-dimyristoyl phosphatidic acid triethylammonium salt (5). The biological activity of 2 as an antiviral drug has also been investigated.
authors.forename: C J
authors.initials: CJ
authors.lastname: Welch
authors.forename: A
authors.initials: A
authors.lastname: Larsson
authors.forename: A C
authors.initials: AC
authors.lastname: Ericson
authors.forename: B
authors.initials: B
authors.lastname: Oberg
authors.forename: R
authors.initials: R
authors.lastname: Datema
authors.forename: J
authors.initials: J
authors.lastname: Chattopadhyaya
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D005347:Fibroblasts / Q000187:drug effects; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000188:drug therapy; D006801:Humans; D051379:Mice; D010743:Phospholipids / Q000138:chemical synthesis / Q000627:therapeutic use; D018139:Simplexvirus / Q000187:drug effects; D012874:Skin Diseases, Infectious / Q000188:drug therapy; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D010743:Phospholipids; D000212:Acyclovir