[Cytoplasmic cAMP receptors in the kidneys of rats of different ages studied by gel filtration].
Cytosol reception of cAMP was explored in the kidneys of Wistar rats aged 15 and 60 days. It was shown by gel filtration on Sephadex G-100 that elevation of the cAMP concentration to 10(-9) and 10(-8) brought about a decrease in the molecular weight of receptor complexes, with this effect being more potent in adult animals. Scatchard's analysis of receptor affinity to cAMP demonstrated that in adult animals, the given parameter was considerably less than in young ones. It is assumed that the age-associated changes in cAMP reception are linked with the development of renal sensitivity to the action of hormones.
Solenov
E I
EI
Ivanova
L N
LN
D000375:Aging; D000818:Animals; D002850:Chromatography, Gel; D000242:Cyclic AMP / Q000378:metabolism*; D003600:Cytosol / Q000032:analysis / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D007668:Kidney / Q000032:analysis* / Q000378:metabolism; D008297:Male; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains; D011953:Receptors, Cyclic AMP / Q000032:analysis*
D011953:Receptors, Cyclic AMP; D000242:Cyclic AMP
Izuchenie tsitoplazmaticheskikh retseptorov tsAMF v pochkakh krys razlichnogo vozrasta s pomoshch'iu gel'-fil'tratsii.