title: Relaxation times of apparently normal cerebral white matter in multiple sclerosis.
abstract: The magnetic resonance imaging (MRI) characteristics of the apparently normal cerebral white matter were studied in a group of 35 patients with clinically definite multiple sclerosis (MS). The proton relaxation times were compared with those in normal control subjects and patients with clinically isolated neurologic lesions of a type common in MS. Significant differences were found between all the patient groups and the control subjects. Changes in the cerebral white matter may be an early feature of MS.
authors.affiliation: Institute of Neurology, National Hospitals for Nervous Diseases, London, England.
authors.forename: I E
authors.initials: IE
authors.lastname: Ormerod
authors.forename: G
authors.initials: G
authors.lastname: Johnson
authors.forename: D
authors.initials: D
authors.lastname: MacManus
authors.forename: E P
authors.initials: EP
authors.lastname: du Boulay
authors.forename: W I
authors.initials: WI
authors.lastname: McDonald
mesh_terms: D001921:Brain / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000175:diagnosis*