title: A note on the mechanism of resistance to anoxia and ischaemia in pathophysiological mammalian myelinated nerve.
abstract: Computer simulation of the action potential in myelinated nerve fibres show that the metabolic cost of conduction of an impulse is less than normal in a slightly depolarised fibre. This would account, at least in part, for the greater resistance to ischaemia and anoxia of nerves from diabetics and other pathophysiological conditions.
authors.forename: J M
authors.initials: JM
authors.lastname: Ritchie
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000503:physiopathology; D004573:Electrolytes / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D007511:Ischemia / Q000503:physiopathology*; D009413:Nerve Fibers, Myelinated / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000098:blood supply / Q000503:physiopathology; D009435:Synaptic Transmission
chemical_list: D004573:Electrolytes; D000251:Adenosine Triphosphatases