Circadian variations in radioligand binding to muscarine receptors in rat brain dependent upon endogenous agonist occupation.
Although total levels of muscarine receptors in the rat forebrain and brainstem are constant at different times of day, there are large circadian changes in the numbers and carbachol-affinities of unoccupied receptors, which appear to reflect varying levels of endogenous acetylcholine-receptor complexes and the activity of cholinergic synapses.
Mash
D C
DC
Flynn
D D
DD
Kalinoski
L
L
Potter
L T
LT
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001921:Brain / Q000502:physiology; D001923:Brain Chemistry; D002940:Circadian Rhythm; D008297:Male; D011813:Quinuclidinyl Benzilate; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000032:analysis*; D009435:Synaptic Transmission
D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate; D000109:Acetylcholine