Suppression of cytotoxic T-cell generation by natural suppressor cells from mice with GVHD is partially reversed by indomethacin.
Natural suppressor cells from the spleens of mice with graft-versus-host disease produced across minor histocompatibility barriers inhibit the in vitro generation of alloreactive cytotoxic T lymphocytes by spleen cells from normal mice. The mechanism of natural suppression was studied; suppression does not require direct cell contact with targets. Exogenous interleukin-2 has no effect in reversing suppression while indomethacin partially reverses the suppression mediated by natural suppressor cells.
Choi
K L
KL
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262.
Maier
T
T
Holda
J H
JH
Claman
H N
HN
D000818:Animals; D002450:Cell Communication; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology*; D007213:Indomethacin / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology; D007519:Isoantigens / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000502:physiology
D007376:Interleukin-2; D007519:Isoantigens; D007213:Indomethacin