Fibronectin plasma levels after cadaver kidney transplantation.
The fibronectin plasma levels of 17 patients undergoing cadaver kidney transplantation were determined serially in the postoperative course using laser nephelometry. While 9 patients retained their grafts (group A), the grafts of 8 patients had to be removed (group B), mainly due to rejection, 3 patients had severe infections. In both groups a significant drop of the plasma fibronectin occurred after surgery. There were no significant differences between the two groups in the mean fibronectin levels. After the initial drop the group A patients exhibited rising values leading to a stable level. Progressively declining fibronectin plasma concentrations were found in 2 of 3 severely infected patients. Fluctuating values were found in 3 group B patients without a clear correlation to the rejection crises or the kidney function. The data suggest that the fibronectin plasma level does not seem to be a prognostic marker for graft rejection. But it might be useful in the important and often difficult differentiation between rejection and infection.
Seitz
R
R
Lutz
M
M
Michalik
R
R
Lange
H
H
Klingemann
H G
HG
Egbring
R
R
D000328:Adult; D002102:Cadaver; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000209:etiology; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000209:etiology; D012771:Shock, Hemorrhagic / Q000209:etiology; D013203:Staphylococcal Infections / Q000209:etiology
D003524:Cyclosporins; D005353:Fibronectins; D003404:Creatinine