title: Restricted replication of BK virus in human lymphocytes.
abstract: Human lymphocytes from either peripheral blood or continuous cultures (P3HR-1 cells) are able to support the replication of prototype polyomavirus BK (BKV) as well as its related strain BO15 virus (BO15V). Instead, human monocytes from peripheral blood, although able to bind and egulf BKV virions, do not express virus-specific antigens within a 50 day observation period. In the light of these results, a probable role is suggested for human mononuclear blood cells in the mechanism of natural infection by polyomaviruses.
authors.forename: M
authors.initials: M
authors.lastname: Portolani
authors.forename: M
authors.initials: M
authors.lastname: Piani
authors.forename: G
authors.initials: G
authors.lastname: Gazzanelli
authors.forename: M
authors.initials: M
authors.lastname: Borgatti
authors.forename: A
authors.initials: A
authors.lastname: Bartoletti
authors.forename: M P
authors.initials: MP
authors.lastname: Grossi
authors.forename: A
authors.initials: A
authors.lastname: Corallini
authors.forename: G
authors.initials: G
authors.lastname: Barbanti-Brodano
mesh_terms: D000956:Antigens, Viral / Q000032:analysis; D001739:BK Virus / Q000502:physiology*; D002478:Cells, Cultured; D004279:DNA, Viral / Q000032:analysis; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology*; D011120:Polyomavirus / Q000502:physiology*; D014779:Virus Replication
chemical_list: D000956:Antigens, Viral; D004279:DNA, Viral