title: Is the urinary excretion of prostaglandin E in man dependent on urine pH?
abstract: The relationship between urine pH, modified by the oral administration of either ammonium chloride or sodium bicarbonate, and the urinary excretion of prostaglandin E (PGE) was studied in healthy female subjects. The urinary concentration of PGE, normally constant in man, was significantly higher (P less than 0.02) in alkaline than in acid urine. pH-dependent metabolism and flow-dependent excretion were identified as two factors liable to obscure the demonstration of the pH-dependency of the urinary excretion rate of PGE in man.
authors.forename: J
authors.initials: J
authors.lastname: Haylor
authors.forename: J M
authors.initials: JM
authors.lastname: Toner
authors.forename: P R
authors.initials: PR
authors.lastname: Jackson
authors.forename: L E
authors.initials: LE
authors.lastname: Ramsay
authors.forename: C J
authors.initials: CJ
authors.lastname: Lote
mesh_terms: D000328:Adult; D000643:Ammonium Chloride / Q000494:pharmacology; D001639:Bicarbonates / Q000494:pharmacology; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009994:Osmolar Concentration; D011458:Prostaglandins E / Q000652:urine*; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D011458:Prostaglandins E; D000643:Ammonium Chloride; D017693:Sodium Bicarbonate