Antibiotics attenuate experimental hypertension in rats.
Hypertension was produced in Sprague-Dawley rats by intramuscular injections of either corticosterone or ACTH. Lower increases in blood pressure to these challenges were observed in Sprague-Dawley rats pretreated with neomycin or vancomycin which alone had no effect on blood pressure or growth. The development of high blood pressure in spontaneously hypertensive rats of a stroke-prone substrain was also attenuated by oral administration of neomycin. These results suggest that experimental hypertension can be modulated by the administration of antibiotics.
Honour
J W
JW
Borriello
S P
SP
Ganten
U
U
Honour
P
P
D000324:Adrenocorticotropic Hormone; D000818:Animals; D003345:Corticosterone; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009355:Neomycin / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D014640:Vancomycin / Q000627:therapeutic use*
D014640:Vancomycin; D000324:Adrenocorticotropic Hormone; D009355:Neomycin; D003345:Corticosterone