[Reparative regeneration of rat liver after treatment with bee venom].
After 70% of the rat liver volume has been resected, certain stimulating effect of a single administration of bee venom (1 mg/kg) on hepatocyte proliferation is revealed. In 4 hours the amount of binuclear hepatocytes increases, and in 22-24 hours increases their mitotic activity. The effect of bee venom is explained as activation of the adenilate cyclase system by means of prostaglandins and adrenal hormones.
Zhdanova
T F
TF
Solopaeva
I M
IM
Orlov
B N
BN
Ivanova
N L
NL
Letina
G A
GA
D000818:Animals; D001514:Bee Venoms / Q000494:pharmacology*; D002467:Cell Nucleus; D000242:Cyclic AMP / Q000378:metabolism; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D008938:Mitosis / Q000187:drug effects; D010766:Phosphorylation; D011506:Proteins / Q000378:metabolism; D051381:Rats
D001514:Bee Venoms; D011506:Proteins; D000242:Cyclic AMP
Reparativnaia regeneratsiia pecheni krys pri deĭstvii pchelinogo iada.