Is etretinate dangerous in Papillon-Lefèvre syndrome?
A 23-year-old girl affected by Papillon-Lefèvre syndrome developed, during Etretinate therapy (1 mg/kg/day), two liver abscesses caused by pyogenic bacteria and a subphrenic abscess. The immunological effects of retinoids may precipitate severe infections in patients with Papillon-Lefèvre syndrome, who probably have a basic, even though not always evident, defect of PMN chemotaxis.
Tosti
A
A
Department of Dermatology, University of Bologna, Italy.
Manuzzi
P
P
Bardazzi
F
F
Costa
A
A
D000328:Adult; D001424:Bacterial Infections / Q000209:etiology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D005050:Etretinate / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000188:drug therapy*; D008100:Liver Abscess / Q000209:etiology*; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010214:Papillon-Lefevre Disease / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D013369:Subphrenic Abscess / Q000209:etiology
D005050:Etretinate