Liver cell dysplasia and hepatocellular carcinoma: a histological and immunohistochemical study.
Liver cell dysplasia (LCD) was found in 28 (60%) of 47 patients with hepatocellular carcinoma (HCC); 22 (79%) of them had associated liver cirrhosis. LCD was more frequently observed in posthepatitic cirrhosis (82%) than in the other forms. Carcinoembryonic antigen (CEA), alpha-1-antitrypsin (AAT) and alpha-fetoprotein (AFP), as demonstrated by the peroxidase-antiperoxidase method, were similarly expressed both in normal and in dysplastic cells. Hepatitis B surface antigen was found in eight cases (17%), six of which were associated with LCD. HBsAg was rarely found in dysplastic cells and frequently displayed a peculiar perinuclear pattern. The possible preneoplastic role of LCD is stressed.
Roncalli
M
M
Borzio
M
M
de Biagi
G
G
Servida
E
E
Cantaboni
A
A
Sironi
M
M
Taccagni
G L
GL
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000032:analysis / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008099:Liver / Q000276:immunology / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications; D008113:Liver Neoplasms / Q000032:analysis / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged