OKT4+ T cell deficiency and an association of immunoglobulin deficiency in systemic lupus erythematosus.
A patient with systemic lupus erythematosus and selective serum IgA and IgM deficiency also had a deficiency of OKT4+, OKT4A+, OKT4B+, and OKT4E+ T cells in circulating blood. This deficiency of helper/inducer T cell subsets in blood was associated with impaired T cell responses to phytohaemagglutinin in vitro, and an impaired ability to produce IgA and IgM by the patient's B cells. The patient's OKT4+ (CD4+) T cell deficient population suppressed IgM synthesis by normal B and T cells.
Raziuddin
S
S
Department of Immunology, King Saud University, College of Medicine, Abha, Saudi Arabia.
Danial
B H
BH
D000328:Adult; D004406:Dysgammaglobulinemia / Q000150:complications; D006801:Humans; D017098:IgA Deficiency; D007108:Immune Tolerance; D007075:Immunoglobulin M / Q000172:deficiency*; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology*; D008297:Male; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D007075:Immunoglobulin M