title: Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide.
abstract: Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. It is concluded that a structural homology exists between the two viruses, despite minimal primary sequence conservation.
authors.forename: E A
authors.initials: EA
authors.lastname: Emini
authors.forename: J V
authors.initials: JV
authors.lastname: Hughes
authors.forename: D S
authors.initials: DS
authors.lastname: Perlow
authors.forename: J
authors.initials: J
authors.lastname: Boger
mesh_terms: D000595:Amino Acid Sequence; D006508:Hepatitis Antibodies / Q000096:biosynthesis*; D006507:Hepatovirus / Q000235:genetics* / Q000276:immunology; D009500:Neutralization Tests; D017955:Poliovirus / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics*; D015678:Viral Structural Proteins
chemical_list: D006508:Hepatitis Antibodies; D014764:Viral Proteins; D015678:Viral Structural Proteins