title: Peripheral nervous tissue injury induced by galactocerebroside and galactocerebroside immune complexes.
abstract: It was demonstrated that New Zealand Albino rabbits sensitized to galactocerebroside had high levels of anti-galactocerebroside antibody and of immune complexes. The rabbits was high titers of immune complexes developed demyelination in the peripheral nerves. Lesion were produced in the peripheral nerves of mice by the i.m. injection of galactocerebroside immune complexes. The lesions were characterized by axonal degeneration, infiltrating macrophages containing myelin debris, and an inflammatory infiltrate of polymorphonuclear and mononuclear cells. Rabbit immunoglobulin and mouse C3 were observed around the endoneural blood vessels. These results suggest that galactocerebroside immune complexes may play a role in the pathogenesis of mouse peripheral nerve lesions, due to the production of vasculomyelinopathy.
authors.forename: N
authors.initials: N
authors.lastname: Tsukada
authors.forename: C S
authors.initials: CS
authors.lastname: Koh
authors.forename: N
authors.initials: N
authors.lastname: Yanagisawa
authors.forename: T
authors.initials: T
authors.lastname: Taketomi
authors.forename: P O
authors.initials: PO
authors.lastname: Behan
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000502:physiology*; D002554:Cerebrosides / Q000276:immunology*; D005699:Galactosylceramides / Q000276:immunology*; D007124:Immunoenzyme Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D011817:Rabbits; D012584:Sciatic Nerve / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D000936:Antigen-Antibody Complex; D002554:Cerebrosides; D005699:Galactosylceramides