Effect of treatment with sodium valproate on plasma adrenocorticotropic hormone and cortisol concentrations in pregnancy.
To investigate whether treatment with valproic acid in pregnancy decreases adrenocorticotropic hormone and cortisol secretion, we measured their concentrations in maternal and umbilical cord blood from a patient receiving valproic acid. We found them to be normal. Valproic acid may not decrease adrenocorticotropic hormone/cortisol levels in pregnant patients or their fetuses.
Hatjis
C G
CG
Rose
J C
JC
Pippitt
C
C
Swain
M
M
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D004831:Epilepsies, Myoclonic / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005333:Fetus / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000188:drug therapy*; D014635:Valproic Acid / Q000009:adverse effects / Q000494:pharmacology*
D014635:Valproic Acid; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone