The biology of papillomaviruses and their role in oncogenesis.
A large number of different papillomavirus types have been identified. Several viruses often infect the same species and each virus is associated with a defined tissue. Recent evidence has shown that certain benign lesions can undergo malignant transformation in both animals and humans in response to genetic or environmental factors. Fine mapping of the structure and function of the viral genome may enhance our understanding of the interaction between the virus and the cofactors involved in malignant transformation.
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D000818:Animals; D052688:Bovine papillomavirus 1; D002274:Carcinogens, Environmental; D002417:Cattle; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D002874:Chromosome Mapping; D003043:Cocarcinogenesis; D012777:Cottontail rabbit papillomavirus; D004261:DNA Replication; D004279:DNA, Viral / Q000096:biosynthesis; D005260:Female; D005833:Genital Neoplasms, Female / Q000382:microbiology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000382:microbiology; D009928:Organ Specificity; D010212:Papilloma / Q000382:microbiology; D027383:Papillomaviridae / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure; D011230:Precancerous Conditions / Q000382:microbiology; D012878:Skin Neoplasms / Q000382:microbiology; D013045:Species Specificity; D014158:Transcription, Genetic; D014412:Tumor Virus Infections / Q000473:pathology* / Q000662:veterinary; D014764:Viral Proteins / Q000096:biosynthesis; D014771:Virion / Q000648:ultrastructure; D014779:Virus Replication; D014860:Warts / Q000382:microbiology
D002274:Carcinogens, Environmental; D004279:DNA, Viral; D014764:Viral Proteins