title: Chromosome 1 abnormalities: a common feature of pediatric solid tumors.
abstract: Abnormalities of chromosome 1 were found in 32 of 46 pediatric solid tumors including Ewing's sarcoma, Wilms' tumor, rhabdomyosarcoma, primitive neuroectodermal tumor, and hepatoblastoma. Trisomy of 1q was the most common abnormality, and breakpoints were most frequent in the region 1cen to 1p22. Abnormalities of chromosome 1 are not specific to any type of tumor. However, their frequent occurrence indicates that they may endow a clonal advantage in the development of cancer.
authors.forename: E C
authors.initials: EC
authors.lastname: Douglass
authors.forename: A A
authors.initials: AA
authors.lastname: Green
authors.forename: F A
authors.initials: FA
authors.lastname: Hayes
authors.forename: E
authors.initials: E
authors.lastname: Etcubanas
authors.forename: M
authors.initials: M
authors.lastname: Horowitz
authors.forename: J A
authors.initials: JA
authors.lastname: Wilimas
mesh_terms: D000782:Aneuploidy; D006528:Carcinoma, Hepatocellular / Q000235:genetics; D002648:Child; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002900:Chromosomes, Human, 1-3 / Q000648:ultrastructure*; D002999:Clone Cells / Q000473:pathology; D054278:Embryonal Carcinoma Stem Cells; D006801:Humans; D008113:Liver Neoplasms; D009369:Neoplasms / Q000235:genetics*; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics; D014411:Neoplastic Stem Cells / Q000473:pathology; D012208:Rhabdomyosarcoma / Q000235:genetics; D012512:Sarcoma, Ewing / Q000235:genetics; D009396:Wilms Tumor / Q000235:genetics