title: [Tetrodotoxin competition with muscimol for the gamma-aminobutyric acid receptor].
abstract: It has been shown that tetrodotoxin inhibits GABA-receptor binding of muscimol with solubilized membranes of the rat brain in a competitive manner, with the inhibition constant amounting to about 3 nM. Muscimol has been also demonstrated to competitively inhibit 3H-tetrodotoxin binding with the same drug.
authors.forename: V I
authors.initials: VI
authors.lastname: Kuznetsov
authors.forename: A K
authors.initials: AK
authors.lastname: Tonkikh
authors.forename: M V
authors.initials: MV
authors.lastname: Karanova
authors.forename: A A
authors.initials: AA
authors.lastname: Sadykov
mesh_terms: D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D009118:Muscimol / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010080:Oxazoles / Q000378:metabolism*; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D012995:Solubility; D013779:Tetrodotoxin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D014316:Tritium; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D010080:Oxazoles; D011963:Receptors, GABA-A; D014316:Tritium; D009118:Muscimol; D013779:Tetrodotoxin; D005680:gamma-Aminobutyric Acid
vernacular_title: Konkurentsiia tetrodotoksina s mustsimolom za retseptor gamma-aminomaslianoĭ kisloty.