title: Changes in 5'-nucleotidase and adenosine deaminase distribution across the rat left ventricle wall during growth and aging.
abstract: The concentrations of the adenosine-generating enzyme 5'-nucleotidase (5'-N) and of the adenosine-degrading enzyme adenosine deaminase (ADA) in the rat left ventricle change as a function of the age of the animal. The enzyme distribution across the left ventricle wall is non-uniform in adult or old rats (in the case of 5'-N) or in all age-groups (in the case of ADA). In the oldest rats, 5'-N activity exhibited a significant increase in the mid-myocardium and in the inner myocardial layers as compared with the young adult controls.
authors.forename: V
authors.initials: V
authors.lastname: De Tata
authors.forename: Z
authors.initials: Z
authors.lastname: Gori
authors.forename: E
authors.initials: E
authors.lastname: Bergamini
mesh_terms: D015720:5'-Nucleotidase; D000243:Adenosine Deaminase / Q000032:analysis*; D000375:Aging; D000818:Animals; D006352:Heart Ventricles / Q000201:enzymology / Q000254:growth & development; D009206:Myocardium / Q000201:enzymology* / Q000648:ultrastructure; D009700:Nucleoside Deaminases / Q000032:analysis*; D009708:Nucleotidases / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009708:Nucleotidases; D015720:5'-Nucleotidase; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase