Dopamine-sensitive adenylate cyclase in rabbit portal vein.
The effect of dopamine (DA) on 3',5'-cyclic adenosine monophosphate (cAMP) generation in the rabbit portal vein was investigated. Dopamine added to homogenates of rabbit portal vein increased the concentration of cAMP. DA-elicited cAMP increase was exclusively inhibited by DA antagonists fluphenazine and haloperidol suggesting the existence of DA receptors (of the DA1 subtype) in the portal vein.
Amenta
F
F
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D000242:Cyclic AMP / Q000032:analysis; D004298:Dopamine / Q000494:pharmacology*; D005260:Female; D005476:Fluphenazine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011169:Portal Vein / Q000201:enzymology*; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits
D011433:Propranolol; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D006220:Haloperidol; D005476:Fluphenazine; D004298:Dopamine; D010646:Phentolamine