Treatment of Alzheimer's disease with a synthetic ACTH 4-9 analog.
The synthetic ACTH 4-9 analog, Org 2766, was administered to 77 Alzheimer's patients for 6 months in a double-blind, placebo-controlled study. Although Org 2766 was tolerated well, no significant effect of Org 2766 could be demonstrated in terms of rating scales or cognitive functions.
Soininen
H
H
Koskinen
T
T
Helkala
E L
EL
Pigache
R
R
Riekkinen
P J
PJ
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000627:therapeutic use*; D010919:Placebos
D010446:Peptide Fragments; D010919:Placebos; C013765:Org 2766; D000324:Adrenocorticotropic Hormone