Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids.
The effects of the stereoisomers dextrorphan and levorphanol on the excitation of spinal neurons by electrophoretically administered excitatory amino acids were studied in pentobarbitone-anaesthetised rats. Both isomers reduced responses to N-methyl-DL-aspartate (NMA), dextrorphan being both more selective and more potent than levorphanol in this respect. This observation supports the proposal that the NMA-blocking activity of a variety of drugs with psychotomimetic properties is subserved by actions at phencyclidine (PCP)/sigma opiate receptors.
Church
J
J
Lodge
D
D
Berry
S C
SC
D000109:Acetylcholine / Q000494:pharmacology; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D003917:Dextrorphan / Q000494:pharmacology*; D007649:Ketamine / Q000494:pharmacology; D007981:Levorphanol / Q000494:pharmacology*; D009019:Morphinans / Q000494:pharmacology*; D016202:N-Methylaspartate; D009474:Neurons / Q000187:drug effects*; D010622:Phencyclidine / Q000494:pharmacology; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects; D017480:Receptors, sigma; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology
D000596:Amino Acids; D009019:Morphinans; D011957:Receptors, Opioid; D017480:Receptors, sigma; D003917:Dextrorphan; D007981:Levorphanol; D001224:Aspartic Acid; D016202:N-Methylaspartate; D007649:Ketamine; D010622:Phencyclidine; D000109:Acetylcholine