In vivo antiviral activity of recombinant murine gamma interferon.
Recombinant murine gamma interferon (gamma-IFN) was tested for its antiviral activity in vivo. IFN preparations purified to greater than 95% purity were administered to CD-1 mice infected with lethal doses of encephalomyocarditis (EMC) virus. An initial treatment with rMuIFN-gamma administered 4 h prior to infection with virus, followed by daily treatment for 3 consecutive days significantly protected mice against EMC virus as evidenced by animal survival after 3-4 weeks post-viral infection. Variations in the antiviral effect relative to dose levels and routes of administration were also studied.
Shalaby
M R
MR
Hamilton
E B
EB
Benninger
A H
AH
Marafino
B J
BJ
D000818:Animals; D004274:DNA, Recombinant; D004686:Encephalomyocarditis virus / Q000187:drug effects; D005260:Female; D007370:Interferon Type I / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D014780:Viruses / Q000187:drug effects*
D004274:DNA, Recombinant; D007370:Interferon Type I; D007371:Interferon-gamma