title: L-AMP-PCP, an ATP receptor agonist in guinea-pig bladder, is inactive on taenia coli.
abstract: L-Adenyl 5'-(beta, gamma-methylene)-diphosphonate (L-AMP-PCP), a potent ATP receptor agonist in the guinea-pig bladder, was tested on the guinea-pig taenia coli. L-AMP-PCP, unlike ATP, did not relax the taenia coli, and it neither enhanced nor inhibited the action of ATP. Unlike ATP, L-AMP-PCP was not degraded by ectonucleotidases on the taenia coli. The lack of pharmacological effect of L-AMP-PCP on the taenia coli supports the suggestion that the ATP receptors here differ from those in the guinea-pig bladder.
authors.forename: S M
authors.initials: SM
authors.lastname: Hourani
authors.forename: L A
authors.initials: LA
authors.lastname: Welford
authors.forename: N J
authors.initials: NJ
authors.lastname: Cusack
mesh_terms: D015720:5'-Nucleotidase; D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D003106:Colon / Q000187:drug effects / Q000378:metabolism*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009708:Nucleotidases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011983:Receptors, Purinergic; D013997:Time Factors; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface; D011983:Receptors, Purinergic; C005147:5'-adenylyl (beta,gamma-methylene)diphosphonate; D000255:Adenosine Triphosphate; D002217:Carbachol; D009708:Nucleotidases; D015720:5'-Nucleotidase; C002630:alpha,beta-methyleneadenosine 5'-triphosphate