GnRH agonists-antagonists--clinical applications.
We know that there is a wide range of clinical applications for GnRH analogues in the field of benign gynaecological disorders. As we understand more of the physiology and mechanism of these GnRH agonists, and there appear more varied and perhaps efficient delivery systems, and antagonists become available, it may be possible to develop a graded approach in suppression of the hypothalamic pituitary axis. The true potential of these agents is then yet to be fully realized. There can be no doubt they are going to influence practice dramatically over the next decade. The potency of these agents, perhaps specifically their effects of oestrogen deficiency and calcium bone metabolism, suggests that limitation of duration of use and timing of recurrent administration to individuals is likely to be necessary.
Shaw
R W
RW
Royal Free Hospital, London, U.K.
D002064:Buserelin / Q000031:analogs & derivatives / Q000627:therapeutic use; D003613:Danazol / Q000627:therapeutic use; D004715:Endometriosis / Q000097:blood / Q000188:drug therapy*; D004958:Estradiol / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D017273:Goserelin; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy*; D017274:Nafarelin; D010014:Osteolysis; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D014594:Uterine Neoplasms / Q000188:drug therapy*
D017273:Goserelin; C025483:estradiol-17 beta-glucuronide; D017274:Nafarelin; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D003613:Danazol; D002064:Buserelin