[Systematic inhibition of the luteinizing hormone with a gonadoliberin analog, triptorelin, during ovarian stimulation for fertilization in vitro. Choice of protocol].
The quality of ovarian stimulation for in vitro fertilization with or without an LH-RH analogue was investigated in a randomized trial involving 30 women divided into 3 groups. Group I women were treated with the conventional clomiphene citrate-human menopausal gonadotropin combination without LH-RH analogue. Group II women (long regimen) received a slow-release preparation of triptorelin (DTRp6-LH-RH), an LH-RH analogue, and human menopausal gonadotropin. Group II women (short regimen) were given triptorelin with human menopausal gonadotropin. Inhibition of the endogenous luteinizing hormone using triptorelin improved the results of in vitro fertilization in group II and group III women, but the short regimen was distinctly less compelling and less expensive than the long regimen.
Fenichel
P
P
Centre de Fécondation in vitro, CHU, Nice.
Grimaldi
M
M
Hieronimus
S
S
Olivero
J F
JF
Donzeau
A
A
Benoit
B
B
Fiorentini
M
M
Tran
D K
DK
Harter
M
M
Gillet
J Y
JY
D000328:Adult; D003692:Delayed-Action Preparations; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007986:Luteinizing Hormone / Q000037:antagonists & inhibitors*; D008186:Luteolytic Agents / Q000494:pharmacology*; D010060:Ovulation / Q000187:drug effects*; D011897:Random Allocation; D013268:Stimulation, Chemical; D017329:Triptorelin Pamoate
D003692:Delayed-Action Preparations; D008186:Luteolytic Agents; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone
Inhibition systématique de l'hormone lutéinisante par un analogue de la gonadolibérine, la triptoréline, au cours de la stimulation ovarienne pour fécondation in vitro. Choix du protocole.