title: Corticosterone modulation of neurotransmitter receptors in rat hippocampus: a quantitative autoradiographic study.
abstract: The effect of adrenalectomy (ADX) and corticosterone (CORT) replacement on neurotransmitter receptors was studied in dorsal hippocampus of rat using quantitative autoradiography. ADX for one week causes an increase in [3H]5-HT binding to 5-HT1 receptors which is significant in the CA1 cell field. CORT treatment of ADX rats for 3-5 days results in localized reductions of [3H]5-HT binding including a partial reversal of the increase observed after ADX in CA1. CORT treatment of ADX animals also decreases binding of [3H]QNB to muscarinic receptors in the dorsal hippocampus, with a significant effect in an area designated as subiculum. No influence of CORT was detected on [3H]prazosin binding to alpha 1 adrenergic receptors in dorsal hippocampus. Possible mechanisms for hormone effects on neurotransmitter receptor levels are discussed.
authors.forename: A
authors.initials: A
authors.lastname: Biegon
authors.forename: T C
authors.initials: TC
authors.lastname: Rainbow
authors.forename: B S
authors.initials: BS
authors.lastname: McEwen
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D001345:Autoradiography; D003345:Corticosterone / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D011985:Receptors, Serotonin / Q000378:metabolism
chemical_list: D011942:Receptors, Adrenergic, alpha; D011976:Receptors, Muscarinic; D017981:Receptors, Neurotransmitter; D011985:Receptors, Serotonin; D011813:Quinuclidinyl Benzilate; D003345:Corticosterone