[Pharmacokinetics of ceftazidime in healthy and renal failure subjects].
Ceftazidime is poorly bound to plasma proteins, is not metabolized and is excreted mostly by glomerular filtration. Its elimination half-life is about 1.5-2 hours, and their kinetics are modified by renal impairment. The dosage recommended in adult is 1 to 2 g 8-hourly, to be adjusted to the needs of individual cases. The interval between doses must be extended to 12 hours in patients with mild renal impairment and to 36-48 hours in those with severe renal failure. A supplementary dose of ceftazidime is required at the end of each haemodialysis session. In patients under chronic peritoneal dialysis, the loading dose (10 mg/kg) is followed by continuous administration of 5 mg/kg into each dialysis cavity.
Leroy
A
A
Hôpital Charles-Nicolle, Rouen.
Fillastre
J P
JP
Humbert
G
G
Borsa
F
F
Leguy
F
F
Spencer
G R
GR
D002442:Ceftazidime / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007676:Kidney Failure, Chronic / Q000097:blood*; D006435:Renal Dialysis
D002442:Ceftazidime
Pharmacocinétique de la ceftazidime chez le sujet sain et chez l'insuffisant rénal.