Inhibitory effects of some organometallic complexes of rhodium(I) and iridium(I) on carrageenin paw edema in rats.
A group of 4 organometallic complexes of Rhodium (I) and 1 Iridium(I) was tested for the evaluation of their anti-inflammatory activity on carrageenin paw edema in rats. All the compounds used inhibited the development of paw edema by more than 50% at different dose-levels. The activity of the pyridinalmethylimine derivative [Rh(COD)PMI]+ Cl- had better results than that of [Rh(NBD)PMI]+ Cl- and even more than the dimeric complexes tested. The higher activity of [Ir(COD)Cl]2 as compared with [Rh(COD)Cl]2 suggests that it would be of interest to examine further Iridium(I) complexes, among which [Ir(COD)PMI]+ Cl- could be a good candidate.
Sava
G
G
Institute of Pharmacology, Faculty of Pharmacy, University of Trieste, Italy.
Piccini
P
P
Mestroni
G
G
Zassinovich
G
G
Bontempi
A
A
D000818:Animals; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D007495:Iridium / Q000627:therapeutic use* / Q000633:toxicity; D008297:Male; D009942:Organometallic Compounds / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012413:Rubidium / Q000627:therapeutic use* / Q000633:toxicity
D009942:Organometallic Compounds; D007495:Iridium; D002351:Carrageenan; D012413:Rubidium