title: [Tomographical use of Tc hexamethylpropylene amine-oxime. First experience (78 studies)].
abstract: A new radiotracer of cerebral perfusion, 99mTc-labelled hexamethylpropylene amine-oxime, has been tried in 78 subjects: 6 controls and 72 patients. Qualitatively, the distribution of this tracer in healthy subjects was very much the same as that obtained with a reference method using 133xenon inhalation. Quantitatively, there was no correlation between the real blood flow rate and the normalized cerebral uptake rate. On the other hand, the asymmetry indices obtained in controls (but also in 16 patients) correlated very closely with those obtained with 133xenon. Our first results in acute ischaemic diseases as well as in the evaluation of vasospasm or Alzheimer-like presenile dementia point to wide fields of application for the new compound. Unlike its predecessors, it is always available and will probably be used, without any logistic investment, with the standard equipment of all Nuclear medicine departments.
authors.affiliation: Service central de Médecine nucléaire, Hôpital B, Centre hospitalier universitaire, Lille.
authors.forename: M
authors.initials: M
authors.lastname: Steinling
authors.forename: P
authors.initials: P
authors.lastname: Kassiotis
authors.forename: A
authors.initials: A
authors.lastname: Mazingue
authors.forename: M
authors.initials: M
authors.lastname: Rousseaux
authors.forename: M
authors.initials: M
authors.lastname: Jomin
authors.forename: D
authors.initials: D
authors.lastname: Leys
authors.forename: P
authors.initials: P
authors.lastname: Dubois
authors.forename: P
authors.initials: P
authors.lastname: Fialdes
authors.forename: E
authors.initials: E
authors.lastname: Ovelacq
authors.forename: R
authors.initials: R
authors.lastname: Vergnes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging; D002545:Brain Ischemia / Q000000981:diagnostic imaging; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging*; D005260:Female; D006406:Hematoma / Q000000981:diagnostic imaging; D006801:Humans; D002546:Ischemic Attack, Transient / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed
chemical_list: D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime
vernacular_title: Utilisation tomographique de l'hexaméthylpropylène amine-oxyme Tc. Première expérience (78 études).