Suppression of amygdala-kindled seizure in cats by enhanced GABAergic transmission in the substantia innominata.
The chronological effect of intracerebral injection of GABAergic drugs, either muscimol or gabaculine, into the substantia innominata, was examined in amygdala-kindled cats. Results obtained indicate: that the substantia innominata may play a significant role in ictal linkage between a nonmotor system such as the amygdala and the motor mechanism responsible for amygdala-kindled convulsion, and that the GABA terminals in the substantia innominata exert a suppressive action toward convulsive seizure generalization of amygdala origin.
Morita
K
K
Okamoto
M
M
Seki
K
K
Wada
J A
JA
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001479:Basal Ganglia / Q000503:physiopathology*; D002415:Cats; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use; D007267:Injections; D007696:Kindling, Neurologic; D009118:Muscimol / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy / Q000503:physiopathology*; D013377:Substantia Innominata / Q000503:physiopathology*; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D003509:Cyclohexanecarboxylic Acids; D009118:Muscimol; C012987:gabaculine; D005680:gamma-Aminobutyric Acid