Effects of nadolol on arrhythmias during laparoscopy performed under general anaesthesia.
Cardiac arrhythmias are a well recognized complication of anaesthesia for laparoscopy. The effect of nadolol, given by mouth 12 h before operation, was compared with placebo on arrhythmias in 86 females undergoing laparoscopy. All types of arrhythmia were documented; there was a 97% incidence in the placebo group, but in the nadolol group there was a smaller incidence of supraventricular tachycardia, ventricular ectopics and atrioventricular dissociation (P less than 0.01). There was no significant difference in the incidence of sinus bradycardia. Nadolol may be recommended as a safe agent to be given by mouth before laparoscopy to reduce the frequency of cardiac arrhythmias during anaesthesia.
Burns
J M
JM
Department of Materia Medica, Stobhill General Hospital, Glasgow.
Hart
D M
DM
Hughes
R L
RL
Kelman
A W
AW
Hillis
W S
WS
D000328:Adult; D000768:Anesthesia, General; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects; D009248:Nadolol / Q000008:administration & dosage / Q000627:therapeutic use*; D011292:Premedication
D009248:Nadolol