[HLA-B27-negative sacroiliitis as a complication of inflammatory forms of acne: case reports and review of the literature].
In this review, three patients with severe inflammatory acne accompanied by a distinct rheumatologic syndrome are discussed together with 44 similar cases reported in the literature. This syndrome, here referred to as "acne-associated arthritis (AAA)" usually involves male teenagers and twins. The most characteristic clinical findings relate to the axial skeleton as well as the sterno-costo-clavicular region. Although no association with HLA-B27 has been found, AAA shares a number of clinical, radiological and histomorphological features with seronegative spondylarthropathies. Furthermore, nosological connections seem to exist with a number of ill-defined "hyperostotic osteoarthropathies." Similar characteristics are known from other "pustulotic or neutrophilic dermatosis." The hypothesis of an infectious etiology of AAA has not been substantiated. Responses to systemic antibiotics are generally disappointing, whereas steroids have been shown to exhibit some therapeutic efficacy.
Saal
J G
JG
Abteilung Innere Medizin II, Universität Tübingen.
Wojatschek
C
C
Rautenstrauch
H
H
D000152:Acne Vulgaris / Q000150:complications*; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000209:etiology*; D005260:Female; D015235:HLA-B Antigens / Q000032:analysis*; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D012446:Sacroiliac Joint
D015235:HLA-B Antigens; D015796:HLA-B27 Antigen
HLA-B27-negative Sacroiliitis als Komplikation entzündlicher Akneformen: Fallberichte und Literaturübersicht.