Guar by-product improves carbohydrate tolerance in rats.
These studies were designed to assess the effect of guar by-product (GBP) upon carbohydrate tolerance in rats. Both 1% and 10% GBP suspensions administered immediately before a glucose challenge (1 g/kg body weight) caused a 31% reduction in the integrated plasma glucose response area during a 180 min test. Because 10% GBP caused a flattened glucose response curve, it was studied further. Ten percent GBP caused a similar reduction in plasma glucose during a 360-minute test; similar plasma insulin levels were measured in both 0% and 10% GBP groups throughout the 360-minute test. Ten percent oat bran and 10% soy bran had no effect upon plasma glucose responses. Ten percent GBP was effective in lowering glycemic excursions after sucrose and starch challenges. Rats fed pellet fractions from water and acid treated GBP had the lowest plasma glucose excursions after a glucose challenge; simulated gastric juice treatment of GBP reduced the hypoglycemic activity and simulated pancreatic juice treatment destroyed it. These studies demonstrate the ability of GBP suspensions to significantly reduce plasma glucose excursions after carbohydrate challenge.
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D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002241:Carbohydrates / Q000008:administration & dosage*; D004043:Dietary Fiber / Q000494:pharmacology*; D004044:Dietary Proteins / Q000494:pharmacology*; D005685:Galactans / Q000494:pharmacology*; D005750:Gastric Juice / Q000032:analysis; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D008297:Male; D008351:Mannans / Q000494:pharmacology*; D053149:Plant Gums; D010940:Plant Proteins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D002241:Carbohydrates; D004043:Dietary Fiber; D004044:Dietary Proteins; D005685:Galactans; D007328:Insulin; D008351:Mannans; D053149:Plant Gums; D010940:Plant Proteins; C045181:guar meal protein, Cyamopsis tetragonoloba; C007894:guar gum