Hyperexcitability following moderate hypoxia in hippocampal tissue slices.
The effects of moderate hypoxia on CA1 pyramidal cells were studied in submerged rat hippocampal tissue slices. Hyperexcitability developed during re-oxygenation following 30-45 min of hypoxia at 29 degrees C. During hypoxia a sustained increase in extracellular potassium was observed. The post-hypoxic hyperexcitability of CA1 neurons may be the result of their inability to fully recover intracellular potassium lost during oxygen deprivation.
Schiff
S J
SJ
Somjen
G G
GG
D000818:Animals; D002463:Cell Membrane Permeability; D006624:Hippocampus / Q000503:physiopathology*; D002534:Hypoxia, Brain / Q000503:physiopathology*; D066298:In Vitro Techniques; D008564:Membrane Potentials; D011188:Potassium / Q000502:physiology; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission
D012964:Sodium; D011188:Potassium