title: Suppression of amygdala-kindled seizure in cats by enhanced GABAergic transmission in the substantia innominata.
abstract: The chronological effect of intracerebral injection of GABAergic drugs, either muscimol or gabaculine, into the substantia innominata, was examined in amygdala-kindled cats. Results obtained indicate: that the substantia innominata may play a significant role in ictal linkage between a nonmotor system such as the amygdala and the motor mechanism responsible for amygdala-kindled convulsion, and that the GABA terminals in the substantia innominata exert a suppressive action toward convulsive seizure generalization of amygdala origin.
authors.forename: K
authors.initials: K
authors.lastname: Morita
authors.forename: M
authors.initials: M
authors.lastname: Okamoto
authors.forename: K
authors.initials: K
authors.lastname: Seki
authors.forename: J A
authors.initials: JA
authors.lastname: Wada
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001479:Basal Ganglia / Q000503:physiopathology*; D002415:Cats; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use; D007267:Injections; D007696:Kindling, Neurologic; D009118:Muscimol / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy / Q000503:physiopathology*; D013377:Substantia Innominata / Q000503:physiopathology*; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D003509:Cyclohexanecarboxylic Acids; D009118:Muscimol; C012987:gabaculine; D005680:gamma-Aminobutyric Acid