title: Plasma levels of atrial natriuretic peptide in patients with borderline and essential hypertension.
abstract: Plasma levels of atrial natriuretic peptide (ANP) were measured in outpatients with borderline hypertension (n = 15) and essential hypertension (n = 13) and in normotensive subject (n = 11). There were no significant differences among the three groups in age, serum protein, albumin, or electrolyte levels, plasma renin activity (PRA), or plasma concentrations of aldosterone and cortisol. The plasma ANP levels in the normotensive, borderline hypertensive, and essential hypertensive subjects were 36 +/- 6 pg/ml (mean +/- S.E.), 64 +/- 11 pg/ml, and 82 +/- 14 pg/ml, respectively. The levels in the essential hypertensive subjects were significantly (p less than 0.05) higher than those in the normotensives. In both borderline and essential hypertensives (n = 28), the plasma ANP levels were significantly correlated positively with systolic blood pressure (r = +0.385, p less than 0.05), and negatively with PRA (r = -0.484, p less than 0.05) and serum total calcium (r = -0.516, p less than 0.01). These results suggest that the elevation of circulating ANP in hypertensives is involved in the pathogenesis of hypertension.
authors.affiliation: Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi.
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Ichikawa
authors.forename: T
authors.initials: T
authors.lastname: Sakamaki
authors.forename: M
authors.initials: M
authors.lastname: Fujie
authors.forename: A
authors.initials: A
authors.lastname: Yagi
authors.forename: T
authors.initials: T
authors.lastname: Kurashina
authors.forename: K
authors.initials: K
authors.lastname: Murata
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood*; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000209:etiology; D008297:Male; D012083:Renin / Q000097:blood
chemical_list: D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin; D002118:Calcium