Chlorpromazine vs. meperidine in the treatment of phencyclidine psychosis.
Patients with phencyclidine psychosis were treated with two 50 mg injections of either chlorpromazine (N = 10) or meperidine (N = 10). The chlorpromazine-treated group responded more rapidly, but the meperidine-treated group had greater overall improvement. It is suggested that meperidine may have a role in the emergency treatment of phencyclidine psychosis. These findings may provide support for the hypothesis that dopaminergic psychosis is mediated by opioids.
Giannini
A J
AJ
Loiselle
R H
RH
Price
W A
WA
Giannini
M C
MC
D000208:Acute Disease; D000328:Adult; D002746:Chlorpromazine / Q000494:pharmacology / Q000627:therapeutic use*; D004723:Endorphins / Q000502:physiology; D006801:Humans; D008297:Male; D008614:Meperidine / Q000494:pharmacology / Q000627:therapeutic use*; D010623:Phencyclidine Abuse / Q000150:complications*; D011569:Psychiatric Status Rating Scales; D011605:Psychoses, Substance-Induced / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D011957:Receptors, Opioid / Q000187:drug effects; D013997:Time Factors
D004723:Endorphins; D011957:Receptors, Opioid; D008614:Meperidine; D002746:Chlorpromazine