Changes in lipid peroxide concentrations in plasma and tissues by repeated administration of clioquinol to neonatal rats.
The changes in lipid peroxide concentrations in plasma and tissues after subcutaneous administration of clioquinol to clioquinol-sensitive (S-rats) and -resistant neonatal rats (R-rats) were investigated. When a fixed dose of 150 mg/kg/d of clioquinol was given to R-rats for 14 d after birth, no significant difference in lipid peroxide concentrations in plasma, liver, kidney, brain and spinal cord at 5, 10 and 15 d was observed between clioquinol-treated and untreated rats. However, with increasing doses of clioquinol to R-rats every 5 d (150----300----600 mg/kg/d), the lipid peroxide concentrations at 15 d were higher in plasma, brain and spinal cord of clioquinol-treated rats than in those of untreated rats. These results suggested that repeated administrations of large doses of clioquinol to rats increased the lipid peroxides in nerve tissues. With S-rats at 5 d after birth, the lipid peroxide concentrations in liver were approximately twice those in R-rats regardless of the clioquinol administration.
Ohshima
N
N
Hospital Pharmacy, Faculty of Medicine, University of Tokyo, Japan.
Kotaki
H
H
Hori
S
S
Saitoh
Y
Y
Nakagawa
F
F
Tamura
Z
Z
D000818:Animals; D000831:Animals, Newborn / Q000097:blood / Q000378:metabolism*; D001259:Ataxia / Q000139:chemically induced; D001835:Body Weight / Q000187:drug effects; D002490:Central Nervous System / Q000378:metabolism; D007464:Clioquinol / Q000008:administration & dosage / Q000494:pharmacology*; D004351:Drug Resistance; D005260:Female; D006912:Hydroxyquinolines / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D006912:Hydroxyquinolines; D008054:Lipid Peroxides; D007464:Clioquinol