[Suppressive action of the influenza virus on the cellular immune reaction].
Experiments in mice using syngeneic transfer of spleen cells and intraperitoneal inoculation of cyclophosphamide, levamisole, hydrocortisone, and anti-0 serum demonstrated that influenza virus may inhibit T-suppressors from the first days of infection. Then the T-helper system of lymphocytes is inhibited and the capacity of the animals to show delayed type hypersensitivity is reduced. In this period, higher activity of T-helpers is observed. It is assumed that inhibition of the T-helper system is associated with the affection by influenza virus of the cells which activate T-helpers.
Frolov
A F
AF
Borisov
V A
VA
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007108:Immune Tolerance / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D009980:Influenza A virus / Q000276:immunology / Q000472:pathogenicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000276:immunology / Q000637:transplantation; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic
Suppressivnoe deĭstvie virusa grippa na kletochnuiu immunnuiu reaktsiiu.