Activation of c-myc gene transcription by Rous sarcoma virus infection.
Transcription of the c-myc gene in chick embryo fibroblast cells was activated 50- to 100-fold by Rous sarcoma virus (RSV) infection. More than 30-fold activation of c-myc gene transcription was also observed in RSV-transformed rat cells as compared with the control cells. The increased expression of c-myc gene in these cells was not due to gene amplification or gene rearrangement. This striking increase in expression of c-myc gene may be relevant to neoplastic transformation of RSV-infected cells.
Kuchino
Y
Y
Nemoto
K
K
Kawai
S
S
Nishimura
S
S
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000235:genetics*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D002642:Chick Embryo; D005347:Fibroblasts; D005786:Gene Expression Regulation; D051381:Rats; D014158:Transcription, Genetic; D014775:Virus Activation