[Somatic cell mutants with altered receptor and endocytosis activities].
Binding and endocytosis are responsible for cellular uptake of a wide variety of physiologically active ligands. We have selected somatic cell mutants with altered endocytosis activity for low-density lipoprotein, insulin, and epidermal growth factor. Of these mutants, the one with altered response to epidermal growth factor shows aberrant growth behavior in soft agar.
Kuwano
M
M
Tomita
K
K
Kuratomi
Y
Y
Yamato
H
H
Masuda
A
A
Ono
M
M
D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D002460:Cell Line; D002478:Cells, Cultured; D002784:Cholesterol / Q000096:biosynthesis; D004705:Endocytosis; D066246:ErbB Receptors; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism*; D009154:Mutation; D011120:Polyomavirus / Q000235:genetics; D011972:Receptor, Insulin / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology*; D013539:Simian virus 40 / Q000235:genetics; D014168:Transferrin / Q000502:physiology
D007328:Insulin; D008077:Lipoproteins, LDL; D011956:Receptors, Cell Surface; D014168:Transferrin; D002784:Cholesterol; D066246:ErbB Receptors; D011972:Receptor, Insulin