title: Effects of systolic overload and swim training on cardiac mechanics and biochemistry in rats.
abstract: We have previously shown that swim conditioning corrects the depressed mechanical function and myosin adenosinetriphosphatase (ATPase) activities associated with renovascular hypertension (HTN) in the rat. The present study was designed to assess the effects of swim conditioning on another form of systolic overload, subdiaphragmatic suprarenal aortic stenosis. Cardiac mechanics in an isolated working heart apparatus and myosin enzymology were studied in four groups of rats: controls (C), animals with chronic systolic overload secondary to aortic constriction (St), swim-conditioning animals (Sw), and animals exposed to a combined load (St-Sw). Heart weight was increased by 23% in St, 27% in Sw, and 36% in St-Sw. In contrast to HTN, cardiac pump and muscle function were not depressed in St. Sw was associated with improved cardiac output, stroke work, and velocity of circumferential fiber shortening. St-Sw showed improved mechanical cardiac performance relative to both C and St. The percent of ventricular myosin of the V1 type and Ca2+-activated myosin ATPase activity relative to C was unchanged in Sw but was depressed in St and St-Sw. These data demonstrate that the salutory mechanical effects of Sw can be superimposed on the systolic overload of St. However, the dissociation between mechanics and myosin enzymology suggests that factors in excitation-contraction coupling other than myosin isoenzyme shifts are responsible for this finding.
authors.affiliation: Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467.
authors.forename: P M
authors.initials: PM
authors.lastname: Buttrick
authors.forename: A
authors.initials: A
authors.lastname: Malhotra
authors.forename: J
authors.initials: J
authors.lastname: Scheuer
mesh_terms: D000818:Animals; D001835:Body Weight; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D003971:Diastole; D005260:Female; D006321:Heart / Q000502:physiology*; D006439:Hemodynamics; D009200:Myocardial Contraction; D009206:Myocardium / Q000201:enzymology; D009218:Myosins / Q000378:metabolism; D009929:Organ Size; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming; D013599:Systole
chemical_list: D009218:Myosins; D000252:Calcium-Transporting ATPases