title: Experimental validation of Doppler echocardiographic measurement of volume flow through the stenotic aortic valve.
abstract: In aortic stenosis, evaluation of aortic valve area by the continuity equation assumes that the volume of flow through the stenotic valve can be measured accurately in the left ventricular outflow tract. To test the accuracy of Doppler volume-flow measurement proximal to a stenotic valve, we developed an open-chest canine model in which the native leaflets were sutured together to create variable degrees of acute aortic stenosis. Left ventricular and aortic pressures were measured with micromanometer-tipped catheters. Volume flow was controlled and varied by directing systemic venous return through a calibrated roller pump and back to the right atrium. Because transaortic volume flow will not equal roller pump output when there is coexisting aortic insufficiency (present in 67% of studies), transaortic flow was measured by electromagnetic flowmeter with the flow probe placed around the proximal descending thoracic aorta, just beyond the ligated arch vessels. In 12 adult, mongrel dogs (mean weight, 25 kg), the mean transaortic pressure gradient ranged from 2 to 74 mm Hg, and transaortic volume flow ranged from 0.9 to 3.2 l/min. In four dogs, electromagnetic flow that was measured distal to the valve was accurate compared with volume flow determined by timed collection of total aortic flow into a graduated cylinder (n = 24, r = 0.97, electromagnetic flow = 0.87 Direct +0.13 l/min). In eight subsequent dogs, electromagnetic flow was compared with transaortic cardiac output measured by Doppler echocardiography in the left ventricular outflow tract as circular cross-sectional area [pi(D/2)2] x left ventricular outflow tract velocity-time integral x heart rate.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, University of Washington, Seattle 98195.
authors.forename: C M
authors.initials: CM
authors.lastname: Otto
authors.forename: A S
authors.initials: AS
authors.lastname: Pearlman
authors.forename: C L
authors.initials: CL
authors.lastname: Gardner
authors.forename: D M
authors.initials: DM
authors.lastname: Enomoto
authors.forename: T
authors.initials: T
authors.lastname: Togo
authors.forename: H
authors.initials: H
authors.lastname: Tsuboi
authors.forename: T D
authors.initials: TD
authors.lastname: Ivey
mesh_terms: D000818:Animals; D001021:Aortic Valve / Q000503:physiopathology*; D001024:Aortic Valve Stenosis / Q000503:physiopathology*; D004452:Echocardiography / Q000379:methods; D055590:Electromagnetic Phenomena / Q000295:instrumentation / Q000379:methods; D005069:Evaluation Studies as Topic; D012039:Regional Blood Flow; D012212:Rheology