Does Caved-S decrease the gastric ulcer relapse rate during maintenance treatment with ranitidine?
Ninety-five patients with healed gastric ulcers were treated with ranitidine 150 mg at night plus either Caved-S two tablets twice daily, or an identical placebo preparation. Treatment was continued for 2 years: the recurrence rate after 1 year was 12.5% for single therapy and 19% for combined therapy, and 30 and 40% respectively after 2 years (differences not significant). No serious side-effects were encountered, but patients found the combination therapy difficult to take, and it conferred no clinical advantage. In a 3 month follow-up after stopping maintenance therapy, 11% of the patients had a symptomatic ulcer recurrence. It is therefore recommended that elderly patients with gastric ulceration should remain on maintenance therapy for life.
Morgan
A G
AG
Endoscopy Unit, Airedale General Hospital, Steeton, Keighley, UK.
Pacsoo
C
C
Taylor
P
P
McAdam
W A
WA
D000328:Adult; D000536:Aluminum Hydroxide / Q000008:administration & dosage*; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D001729:Bismuth / Q000008:administration & dosage*; D004311:Double-Blind Method; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D006035:Glycyrrhiza; D006801:Humans; D008276:Magnesium Hydroxide; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage*; D011899:Ranitidine / Q000008:administration & dosage*; D012008:Recurrence; D017693:Sodium Bicarbonate; D013276:Stomach Ulcer / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D004338:Drug Combinations; D010936:Plant Extracts; C002792:aluminum hydroxide, bismuth subnitrate, deglycyrrhizinised liquorice, magnesium carbonate, sodium bicarbonate drug combination; D000536:Aluminum Hydroxide; D011899:Ranitidine; D017693:Sodium Bicarbonate; D008276:Magnesium Hydroxide; D001729:Bismuth