Perturbations of lens development in the transgenic mouse.
Interference with specific features of cell growth and differentiation in vivo offers rare insights into the complex mechanism of cell proliferation in the developing organism. We have inserted in the germ line of mice transgenes which direct dominant changes in cell development and proliferation to the lens, a tissue exquisitely suited for in vivo analysis. Lens-specific expression of SV40 T antigens results in malignant lens tumors or phakomas, that of a murine c-mos protooncogene in a characteristic defect of lens fiber differentiation.
Westphal
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Section on Mammalian Gene Regulation, National Institute of Child Health and Human Development, Bethesda, MD 20892.
D000818:Animals; D005786:Gene Expression Regulation; D007908:Lens, Crystalline / Q000254:growth & development* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic / Q000254:growth & development*; D009856:Oncogene Proteins, Viral; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D017231:Proto-Oncogene Proteins c-mos
D009856:Oncogene Proteins, Viral; D011518:Proto-Oncogene Proteins; D017231:Proto-Oncogene Proteins c-mos