Selected pharmacological and immunopharmacological indices of ibuprofen.
Affinity of ibuprofen to cellular immune reactions was evaluated in the light of its basic pharmacological indices. Ibuprofen was observed to modulate some immunological phenomena with marked predominance of immunosuppressive component. It has been shown that at least to some extent, mechanism of its effect consists in an interference in T-suppressor cell activity.
Giełdanowski
J
J
Department of Experimental Therapy, Polish Academy of Sciences, Wrocław.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D006168:Guinea Pigs; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology* / Q000633:toxicity; D007107:Immune System / Q000187:drug effects*; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000187:drug effects; D008214:Lymphocytes / Q000145:classification / Q000187:drug effects; D051379:Mice; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects
D007052:Ibuprofen