title: Chromosomal aberrations induced by restriction endonucleases.
abstract: Restriction endonucleases (REs) are able to induce chromosomal aberrations in Chinese hamster ovary (CHO) cells. The G1 phase of the cell cycle seems to be especially sensitive for the induction of chromosomal aberrations by REs. The different capacities of REs to induce chromosomal aberrations are probably correlated with the number of recognition sites in the genome.
authors.forename: G
authors.initials: G
authors.lastname: Obe
authors.forename: F
authors.initials: F
authors.lastname: Palitti
authors.forename: C
authors.initials: C
authors.lastname: Tanzarella
authors.forename: F
authors.initials: F
authors.lastname: Degrassi
authors.forename: R
authors.initials: R
authors.lastname: De Salvia
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002460:Cell Line; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004262:DNA Restriction Enzymes / Q000633:toxicity*; D005260:Female; D007399:Interphase; D010053:Ovary
chemical_list: D004262:DNA Restriction Enzymes