[Lipid peroxidation and free radicals. Role in cellular biology and pathology].
Membrane phospholipids attack by oxygen free radicals, i.e. lipidoperoxidation, occurs in normal cellular life. This free radicals attack is controlled by a protective system, both enzymatic (superoxide dismutase, catalase, glutahione peroxidase) and non enzymatic (vitamine E). Imbalance between attack and defense can explain many pathological events. In these events, the oxidation products of unsaturated fatty acids are of fundamental importance, in particular those derived from arachidonic acid (prostaglandins, prostacyclins, thromboxanes and leukotrienes).
Clavel
J P
JP
Emerit
J
J
Thuillier
A
A
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D000975:Antioxidants; D002374:Catalase / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism; D005609:Free Radicals / Q000528:radiation effects; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism; D008833:Microcirculation; D009369:Neoplasms / Q000209:etiology; D010084:Oxidation-Reduction / Q000528:radiation effects; D010100:Oxygen / Q000378:metabolism; D010545:Peroxides / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D014801:Vitamin A / Q000502:physiology; D014810:Vitamin E / Q000502:physiology
D000970:Antineoplastic Agents; D000975:Antioxidants; D005609:Free Radicals; D006878:Hydroxides; D008054:Lipid Peroxides; D010545:Peroxides; D013481:Superoxides; D014801:Vitamin A; D014810:Vitamin E; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D010100:Oxygen
Lipidoperoxydation et radicaux libres. Rôle en biologie cellulaire et en pathologie.