Progestagen-dependent effect on some plasma proteins during oral contraception.
Seventeen healthy women received a combination of 0.030 mg of ethinyl estradiol and 0.150 mg of levonorgestrel or a combination of 0.030 mg of ethinyl estradiol and 0.150 mg of desogestrel for 2 years as oral contraception. Serum levels of sex hormone binding globulin, transcortin, ceruloplasmin, and pregnancy-associated protein were measured before contraception, during 3, 6, 12, 18, and 24 months of treatment, and 2 months after stopping the pill. Oral contraception with both preparations induced a similar, significant rise in both ceruloplasmin and pregnancy-associated protein. Sex hormone binding globulin levels rose significantly with the ethinyl estradiol-desogestrel, but not with the ethinyl estradiol-levonorgestrel combination. Transcortin increased with both preparations, more with the ethinyl estradiol-desogestrel combination.
Liukko
P
P
Department of Obstetrics and Gynecology, University Central Hospital of Turku, Finland.
Erkkola
R
R
Bergink
E W
EW
D001798:Blood Proteins / Q000032:analysis*; D002570:Ceruloplasmin / Q000097:blood; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology*; D017135:Desogestrel; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D016912:Levonorgestrel; D009644:Norgestrel / Q000494:pharmacology; D009652:Norpregnenes / Q000494:pharmacology; D011257:Pregnancy Proteins / Q000097:blood; D045167:Progesterone Congeners / Q000494:pharmacology*; D012738:Sex Hormone-Binding Globulin / Q000097:blood; D014156:Transcortin / Q000097:blood
D001798:Blood Proteins; D003277:Contraceptives, Oral, Combined; D009652:Norpregnenes; D011257:Pregnancy Proteins; D045167:Progesterone Congeners; D012738:Sex Hormone-Binding Globulin; D009644:Norgestrel; D004997:Ethinyl Estradiol; D016912:Levonorgestrel; D017135:Desogestrel; D014156:Transcortin; D002570:Ceruloplasmin