Oxygen radicals in the adult respiratory distress syndrome, in myocardial ischemia and reperfusion injury, and in cerebral vascular damage.
Recent work suggests that oxygen radicals may be important mediators of damage in a wide variety of pathologic conditions. In this review we consider the evidence supporting the participation of oxygen radicals in the adult respiratory distress syndrome, in ischemia reperfusion injury in the myocardium, and in cerebral vascular injury in acute hypertension and traumatic brain injury. In the adult respiratory distress syndrome there is active sequestration of polymorphonuclear neutrophils in the pulmonary vascular system. There is evidence that activation of these neutrophils results in the production of oxygen radicals which injure the capillary membrane and increase permeability, leading to progressive hypoxia and decreased lung compliance which are hallmarks of the syndrome. In acute arterial hypertension or experimental brain injury oxygen radicals are important mediators of vascular damage. The metabolism of arachidonic acid is the source of oxygen free radical production in these conditions. In myocardial ischemia and reperfusion injury, the ischemic myocyte is "primed" for free radical production. With reperfusion and reintroduction of molecular oxygen there is a burst of oxygen radical production resulting in extensive tissue destruction. Myocardial ischemia--reperfusion injury shares in common with the other two syndromes activation of the arachidonic acid cascade and acute inflammation. Thus it would appear that the generation of toxic oxygen species may represent a final common pathway of tissue destruction in several pathophysiologic states.
Hammond
B
B
Kontos
H A
HA
Hess
M L
ML
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001696:Biomechanical Phenomena; D001930:Brain Injuries / Q000503:physiopathology; D002415:Cats; D002561:Cerebrovascular Disorders / Q000503:physiopathology*; D003327:Coronary Disease / Q000503:physiopathology*; D004798:Enzymes / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D010100:Oxygen / Q000378:metabolism / Q000502:physiology*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology*; D012756:Sheep; D013481:Superoxides / Q000378:metabolism; D014652:Vascular Diseases / Q000503:physiopathology
D001095:Arachidonic Acids; D004798:Enzymes; D005609:Free Radicals; D013481:Superoxides; D016718:Arachidonic Acid; D010100:Oxygen