Transformation of human fetal thymus and spleen lymphocytes by human T-cell leukemia virus type I.
Co-cultivation of human thymus and spleen lymphocytes, which were obtained from 26-week and 27-week fetuses, with a lethally-irradiated human cord T-cell line harboring human T-cell leukemia virus type I (HTLV-I) resulted in the establishment of T-cell lines positive for adult T-cell leukemia-associated antigens and producing HTLV-I. These cell lines had the phenotype of a helper/inducer subset of peripheral T-cells as evidenced by the reactivity with monoclonal antibodies to human T-cells.
Akagi
T
T
Ohtsuki
Y
Y
Shiraishi
Y
Y
Miyoshi
I
I
D002472:Cell Transformation, Viral; D017977:Deltaretrovirus / Q000254:growth & development*; D005260:Female; D005333:Fetus; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D011247:Pregnancy; D013154:Spleen / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology*