title: Inhibition of the inductive activity of demineralized bone matrix by different percutaneous implants.
abstract: Teflon tubes with either Gore-Tex (PTFE) or Dacron felt sleeves were implanted percutaneously in rats, in conjunction with demineralized bone matrix. This resulted in different inflammatory reactions, as well as in chondrogenesis and osteogenesis in the subcutaneous tissues. Although induction of osteogenesis by the demineralized bone matrix in the vicinity of the foreign material was inhibited, circumferential bone formation was highly reproducible. The prospect of utilizing demineralized bone matrix in order to enhance acceptance of percutaneous tubes is discussed.
authors.affiliation: Joseph Lunenfeld Cardiac Surgery Research Center, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Uretzky
authors.forename: J
authors.initials: J
authors.lastname: Appelbaum
authors.forename: J
authors.initials: J
authors.lastname: Sela
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001857:Bone Matrix / Q000502:physiology*; D002113:Calcification, Physiologic; D002356:Cartilage / Q000502:physiology; D002455:Cell Division; D007249:Inflammation / Q000209:etiology / Q000473:pathology; D008903:Minerals / Q000378:metabolism*; D010012:Osteogenesis; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D019736:Prostheses and Implants / Q000009:adverse effects; D051381:Rats; D012867:Skin
chemical_list: D001672:Biocompatible Materials; D008903:Minerals; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene