title: Central dipsogenic effect of synthetic rat atrial natriuretic polypeptide in normotensive rats.
abstract: The effect of intracerebroventricular (i.c.v.) injection of synthetic rat atrial natriuretic polypeptide (alpha-rANP) on drinking behavior was studied in normotensive rats, alpha-rANP (0.2, 0.4 or 0.8 micrograms in 5 microliter) caused a dose-dependent dipsogenic effect which was abated by i.c.v. pretreatment with saralasine (9 micrograms in 5 microliter). These results suggest that alpha-rANP possesses dipsogenic effects in water repleted rats and that brain angiotensin is involved. In addition, our data indicate that, at least as far as the effect of cerebral ANP is concerned, there are some differences between alpha-rANP and human atrial natriuretic polypeptide.
authors.affiliation: Institute of Pharmacology, Medical School, University of Messina, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Squadrito
authors.forename: G
authors.initials: G
authors.lastname: Calapai
authors.forename: A
authors.initials: A
authors.lastname: Autolitano
authors.forename: N
authors.initials: N
authors.lastname: Frisina
authors.forename: G
authors.initials: G
authors.lastname: Santoro
authors.forename: M
authors.initials: M
authors.lastname: Buemi
authors.forename: G
authors.initials: G
authors.lastname: Squadrito
authors.forename: A P
authors.initials: AP
authors.lastname: Caputi
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004327:Drinking Behavior / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009320:Atrial Natriuretic Factor