[Effect of benzonal on the liver mono-oxygenase system of laboratory animals].
The data are provided on benzonal as having the properties of the monoxygenase system inducer, evidenced by the shortening of hexenal sleep, increase of the intensity of the epr-signal of cytochrome P-450, activation of lipid peroxidation, carboxylesterase and arylesterase in the liver. The properties of benzonal described can be made use of for increasing the body resistance to the toxic action of xenobiotics.
Savateev
N V
NV
Liniuchev
M N
MN
Sergeev
V V
VV
Panov
B P
BP
Ovsiannikova
L M
LM
D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004578:Electron Spin Resonance Spectroscopy; D004790:Enzyme Induction / Q000187:drug effects; D006591:Hexobarbital / Q000494:pharmacology; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010105:Oxygenases / Q000096:biosynthesis*; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D001463:Barbiturates; D008054:Lipid Peroxides; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D010105:Oxygenases; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; C002915:benzobarbital
Vliianie benzonala na monooksigenaznuiu sistemu pecheni laboratornykh zhivotnykh.