Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus.
The 9,213-nucleotide structure of the AIDS/lymphadenopathy virus has been determined from molecular clones representing the integrated provirus and viral RNA. The sequence reveals that the virus is highly polymorphic and lacks significant nucleotide homology with type C retroviruses characterized previously. Together with an analysis of the two major viral subgenomic RNAs, these studies establish the coding frames for the gag, pol and env genes and predict the expression of a novel gene at the 3' end of the genome unrelated to the X genes of HTLV-1 and -II.
Muesing
M A
MA
Smith
D H
DH
Cabradilla
C D
CD
Benton
C V
CV
Lasky
L A
LA
Capon
D J
DJ
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology*; D001483:Base Sequence; D004247:DNA; D004274:DNA, Recombinant; D017977:Deltaretrovirus / Q000235:genetics*; D005814:Genes, Viral; D006801:Humans; D009693:Nucleic Acid Hybridization; D014176:Protein Biosynthesis; D012367:RNA, Viral; D014158:Transcription, Genetic; D014759:Viral Envelope Proteins / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics
D004274:DNA, Recombinant; D012367:RNA, Viral; D014759:Viral Envelope Proteins; D014764:Viral Proteins; D004247:DNA