title: Localization of DNA sequences in region Xp21 of the human X chromosome: search for molecular markers close to the Duchenne muscular dystrophy locus.
abstract: Panels of somatic cell hybrid lines carrying various structural rearrangements of the human X chromosome short arm were analyzed with 21 X-chromosome-specific cloned DNA fragments. We mapped these molecular markers to five different regions of the short arm of the X chromosome. The results were confirmed by gene-dosage studies of human lymphoblasts with structurally abnormal X chromosomes. The ornithine transcarbamylase gene and four anonymous DNA sequences map within band Xp21, flanking the presumed locus for Duchenne muscular dystrophy.
authors.forename: B
authors.initials: B
authors.lastname: de Martinville
authors.forename: L M
authors.initials: LM
authors.lastname: Kunkel
authors.forename: G
authors.initials: G
authors.lastname: Bruns
authors.forename: F
authors.initials: F
authors.lastname: Morlé
authors.forename: M
authors.initials: M
authors.lastname: Koenig
authors.forename: J L
authors.initials: JL
authors.lastname: Mandel
authors.forename: A
authors.initials: A
authors.lastname: Horwich
authors.forename: S A
authors.initials: SA
authors.lastname: Latt
authors.forename: J F
authors.initials: JF
authors.lastname: Gusella
authors.forename: D
authors.initials: D
authors.lastname: Housman
mesh_terms: D000818:Animals; D001483:Base Sequence; D002871:Chromosome Banding; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D051379:Mice; D009136:Muscular Dystrophies / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D051381:Rats; D014960:X Chromosome
chemical_list: D005819:Genetic Markers; D004247:DNA; D004262:DNA Restriction Enzymes