title: Suprachiasmatic nucleus ablation abolishes circadian rhythms in rat brain neurotransmitter receptors.
abstract: The effect of suprachiasmatic nucleus (SCN) ablation on rhythms in brain neurotransmitter receptors was studied. In control animals, the rhythms in the number of alpha-adrenergic and benzodiazepine receptors were circadian, whereas the rhythms in beta-adrenergic and acetylcholine receptors were ultradian. SCN ablation resulted in loss of circadian, but not ultradian, rhythms, without change in the 24-h mean numbers. SCN ablation appears to cause a selective loss of circadian function in the regulation of brain receptors.
authors.forename: M S
authors.initials: MS
authors.lastname: Kafka
authors.forename: P J
authors.initials: PJ
authors.lastname: Marangos
authors.forename: R Y
authors.initials: RY
authors.lastname: Moore
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002940:Circadian Rhythm; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011963:Receptors, GABA-A / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013493:Suprachiasmatic Nucleus / Q000502:physiology*
chemical_list: D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011963:Receptors, GABA-A; D011976:Receptors, Muscarinic; D017981:Receptors, Neurotransmitter