title: Magnetic resonance microscopy in neurologic models.
abstract: Magnetic resonance imaging techniques have been developed to permit imaging with slice thickness less than 1 mm and pixels of 50 x 50 microns. Special purpose gradient and radiofrequency coils and three-dimensional imaging techniques enable acquisition of images with sufficient signal to noise to utilize these microscopic picture elements. Live 200 g rats were imaged enabling clear definition of gray and white matter structures. Examples include the Sylvian aqueduct and the substantia nigra. Three-dimensional microscopic images of live chick embryos enabled definition of ventricles and brain parenchyma as well as measurement of T1 over the set of 16 contiguous 1.2 mm slices.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, North Carolina.
authors.forename: G A
authors.initials: GA
authors.lastname: Johnson
authors.forename: M B
authors.initials: MB
authors.lastname: Thompson
authors.forename: B P
authors.initials: BP
authors.lastname: Drayer
authors.forename: S N
authors.initials: SN
authors.lastname: Bone
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000166:cytology; D002642:Chick Embryo; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051381:Rats