title: Prefrontal cortex dysfunction as a common factor in psychosis.
abstract: It has recently become possible to arrive at a testable biopsychological model, according to which a dysfunction of the prefrontal cortex is the common factor in psychotic disorders; if persistent, this leads to a dissolution of the highest level of brain function, in the sense of Hughlings Jackson. The model is in agreement with newer findings in normal and pathological physiology and can serve as basis for specific experimental questions. It is compatible with a unitary epistemological viewpoint.
authors.forename: H F
authors.initials: HF
authors.lastname: Müller
mesh_terms: D001143:Arousal / Q000502:physiology; D004569:Electroencephalography; D005071:Evoked Potentials; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D009434:Neural Pathways / Q000503:physiopathology; D009474:Neurons / Q000502:physiology; D011618:Psychotic Disorders / Q000503:physiopathology* / Q000523:psychology; D012559:Schizophrenia / Q000503:physiopathology; D009435:Synaptic Transmission; D013787:Thalamic Nuclei / Q000503:physiopathology