title: Comparative toxicity of PCBs and related compounds in various species of animals.
abstract: There are several basic principles that apply to the clinicopathologic syndrome produced by polychlorinated biphenyls (PCBs). They are as follows: The degree of halogenation and position of the halogen atoms determine the potency of PCB, PBB, CDD, CDF and CN; in a given species of animals, the clinicopathologic syndrome induced by PCB is comparable to that induced by polybrominated biphenyls (PBB), chlorinated dibenzo-p-dioxins (CDD), chlorinated dibenzofurans (CDF), and chlorinated naphthalenes (CN) when an equitoxic dose is achieved; The clinicopathologic syndrome is different in each species of animals; Different species of animals vary in their susceptibility to intoxication; intoxication is more readily effected in young animals that in adults; at lethal doses the time between exposure and death is prolonged (greater than 2 weeks).
authors.forename: E E
authors.initials: EE
authors.lastname: McConnell
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000633:toxicity; D001769:Blood / Q000187:drug effects; D001774:Blood Chemical Analysis; D006224:Cricetinae; D000072338:Dibenzofurans, Polychlorinated; D005260:Female; D006168:Guinea Pigs; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity; D008099:Liver / Q000187:drug effects; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D009281:Naphthalenes / Q000633:toxicity; D009929:Organ Size / Q000187:drug effects; D011075:Polybrominated Biphenyls / Q000633:toxicity; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects; D013045:Species Specificity; D013270:Stomach / Q000187:drug effects; D014551:Urinary Tract / Q000187:drug effects
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D006843:Hydrocarbons, Chlorinated; D009281:Naphthalenes; D011075:Polybrominated Biphenyls; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls