Inhibition of phosphatidylinositol phosphodiesterase activity in skeletal muscle by metal ions and drugs which block neuromuscular transmission.
The calcium-dependent phosphatidylinositol phosphodiesterase activity of skeletal muscle cytosol was determined. The enzyme was inhibited by Zn2+, Cu2+ and Pb2+ ions but Mg2+ and Mn2+ were without effect. The antimalarial drugs chloroquine and the quinine and the aminoglycoside antibiotics gentamicin and neomycin all of which, like Zn2+, have been shown to block neuromuscular transmission, also inhibited the enzyme.
Shute
J K
JK
Smith
M E
ME
D000617:Aminoglycosides / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008670:Metals / Q000494:pharmacology*; D009132:Muscles / Q000201:enzymology*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D010726:Phosphodiesterase Inhibitors; D010727:Phosphoric Diester Hydrolases; D011803:Quinine / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D008670:Metals; D009466:Neuromuscular Blocking Agents; D010726:Phosphodiesterase Inhibitors; D002738:Chloroquine; D011803:Quinine; D010727:Phosphoric Diester Hydrolases; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D002118:Calcium