Comparison of the gastric antisecretory effects of ramixotidine dihydrochloride (CM 57755), a new H2 receptor antagonist, and cimetidine in dogs.
This paper compares the effects of ramixotidine dihydrochloride (CM 57755) with those of cimetidine on gastric acid secretion and gastrin release in conscious dogs chronically fitted with Heidenhain pouches and/or gastric fistulae. At equimolar doses, intravenous (i.v.) or intragastric (i.g.) CM 57755 caused similar inhibition of dimaprit- or pentagastrin-induced secretion than cimetidine. Acid secretion stimulated by a meat meal was significantly reduced by both CM 57755 and cimetidine. Neither CM 57755 (4.5 and 9 mumol/kg) nor cimetidine (4 mumol/kg) modified gastrin release, while cimetidine (8 mumol/kg) significantly increased it. Judging from these results, while CM 57755 appears to be an inhibitor of gastric acid secretion induced by different stimulants in dogs with potency comparable to cimetidine. The increase in plasma gastrin levels seen after cimetidine but not after CM 57755 suggests that cimetidine releases gastrin by a mechanism independent of H2 receptor antagonism.
Soldani
G
G
Laboratory of Pharmacology, Veterinary School, University of Pisa, Italy.
Lavezzo
A
A
Bianchetti
A
A
Manzoni
L
L
Mengozzi
G
G
Manara
L
L
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002927:Cimetidine / Q000494:pharmacology*; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism; D008297:Male; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D011970:Receptors, Histamine H2 / Q000187:drug effects*
D000897:Anti-Ulcer Agents; D005755:Gastrins; D011970:Receptors, Histamine H2; D009536:Niacinamide; D002927:Cimetidine; C041784:ramixotidine; D010418:Pentagastrin