[Effect of the neuropeptide tuftsin and its derivatives on metabolism in various structures of the brain].
A study was made of the effect of the neuropeptide tuftsin and its derivatives on some indicators of the metabolism in limbic structures and cortex of the brain in 200 rats. It was shown that tuftsin and its derivatives raise the content of nicotinamide coenzymes at the expense of the oxidized forms of NAD, activate cytochrome-c-oxidase and dehydrogenases largely in the limbic structures. Thus the peptides under study were found to increase the intensity of cell respiration and to enhance intracellular redox processes, i. e. to largely activate the vital activity of the cells of the brain emotiogenous structures.
Begum
R
R
Maksimovich
Ia B
IaB
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology; D002952:Citric Acid Cycle / Q000187:drug effects; D003576:Electron Transport Complex IV / Q000378:metabolism; D008032:Limbic System / Q000187:drug effects / Q000201:enzymology; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D014405:Tuftsin / Q000031:analogs & derivatives* / Q000494:pharmacology*
D009243:NAD; D009249:NADP; D003576:Electron Transport Complex IV; D014405:Tuftsin
Vliianie neĭropeptida taftsina i ego proizvodnykh na obmen veshchestv v razlichnykh strukturakh golovnogo mozga.