Expression of atrial natriuretic factor gene in hearts from neonates of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats.
In order to further elucidate the expression of the atrial natriuretic factor (ANF) gene in spontaneously hypertensive rats (SHR) and the substrain, stroke-prone SHR (SHRSP), ANF messenger (m)RNA levels in the atrium and in the ventricle were measured in neonates of SHR and SHRSP and were compared with those in control Wistar-Kyoto rats (WKY). The levels of ANF mRNA in ventricles of the three strains reached approximately 7% of those in atria; however, no significant difference was observed in atrial and ventricular ANF mRNA levels among the three strains. These results demonstrate that the expression of the ANF gene in hearts from neonates of WKY, SHR and SHRSP is similar among the three strains.
Arai
H
H
Department of Medicine, Kyoto University School of Medicine, Japan.
Nakao
K
K
Saito
Y
Y
Sugawara
A
A
Yamada
T
T
Itoh
H
H
Mukoyama
M
M
Hosoda
K
K
Shirakami
G
G
Morii
N
N
D000818:Animals; D000831:Animals, Newborn; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D015152:Blotting, Northern; D002561:Cerebrovascular Disorders / Q000235:genetics*; D005786:Gene Expression Regulation; D006321:Heart / Q000502:physiology*; D006973:Hypertension / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011918:Rats, Inbred SHR / Q000235:genetics*; D011919:Rats, Inbred Strains / Q000235:genetics*
D012333:RNA, Messenger; D009320:Atrial Natriuretic Factor