[Medical genetic study of the population of Kostroma Province. V. The hereditary pathology burden of urban and rural populations].
Medical genetic study was carried out in the urban and rural populations of Kostroma Province. Urban populations were shown to have lower frequencies of "rare" forms of autosomal recessive diseases, in comparison with those in the rural populations. Analysis of interrelationship between genetical structure of populations and prevalencies of hereditary diseases in the populations revealed clear relations between the load of autosomal recessive diseases and the level of inbreeding in the populations.
Petrin
A N
AN
Ginter
E K
EK
Khisamova
M V
MV
D002869:Chromosome Aberrations / Q000453:epidemiology / Q000235:genetics; D025063:Chromosome Disorders; D004198:Disease Susceptibility; D005799:Genes, Dominant; D005808:Genes, Recessive; D030342:Genetic Diseases, Inborn / Q000453:epidemiology* / Q000235:genetics; D008040:Genetic Linkage; D005828:Genetics, Population; D006801:Humans; D011336:Probability; D012424:Rural Population; D012426:Russia; D014505:Urban Population; D014960:X Chromosome
Mediko-geneticheskoe izuchenie naseleniia Kostromskoĭ oblasti. Soobshchenie V. Otiagoshchennost' nasledstvennoĭ patologieĭ gorodskikh i sel'skikh populiatsiĭ.