title: Adenylate cyclase activity as a function of forskolin concentration.
abstract: The activation of adenylate cyclase by forskolin was investigated in terms of the dissociation model of guanyl nucleotide binding protein (Ns). It was demonstrated that the biphasic forskolin concentration-response of adenylate cyclase could be explained by the dissociation of the beta subunit. The equations developed from such a theoretical approach gave an accurate description of concentration response data from S49 cultured mouse lymphoma cells.
authors.forename: R
authors.initials: R
authors.lastname: Barber
authors.forename: T J
authors.initials: TJ
authors.lastname: Goka
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D005576:Colforsin; D000242:Cyclic AMP / Q000378:metabolism; D004224:Diterpenes / Q000032:analysis* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D008223:Lymphoma / Q000378:metabolism; D008433:Mathematics; D051379:Mice
chemical_list: D004224:Diterpenes; D005576:Colforsin; D000242:Cyclic AMP; D000262:Adenylyl Cyclases