title: Prevention of vascular prosthetic infection with an antibiotic-bonded Dacron graft.
abstract: Surfactant-mediated antibiotic bonding was used in an animal model of aortic prosthetic infection. Control grafts, control plus parenteral oxacillin, and oxacillin-bonded Dacron grafts were challenged by local inoculation with Staphylococcus aureus. Ninety percent of controls, 80% of parenteral antibiotic recipients, and only 30% of antibiotic-bonded Dacron grafts became infected (p less than 0.01, p less than 0.03). Antibiotic-bonded grafts were also superior in terms of suture line cultures and patency. In separate experiments in a subcutaneous pouch model, antibiotic bonding significantly improved the median infective dose of Dacron over that of controls and Dacron soaked in cephalosporin. These studies demonstrate that antibiotic-bonded Dacron implants are highly resistant to infection. A multicenter clinical trial is planned.
authors.affiliation: Department of Surgery, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903-0019.
authors.forename: W B
authors.initials: WB
authors.lastname: Shue
authors.forename: S C
authors.initials: SC
authors.lastname: Worosilo
authors.forename: A P
authors.initials: AP
authors.lastname: Donetz
authors.forename: S Z
authors.initials: SZ
authors.lastname: Trooskin
authors.forename: R A
authors.initials: RA
authors.lastname: Harvey
authors.forename: R S
authors.initials: RS
authors.lastname: Greco
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001012:Aorta, Abdominal / Q000601:surgery; D001807:Blood Vessel Prosthesis; D002440:Cefoxitin / Q000008:administration & dosage; D002511:Cephalosporins / Q000008:administration & dosage; D015169:Colony Count, Microbial; D004285:Dogs; D004343:Drug Implants; D004866:Equipment Contamination; D010068:Oxacillin / Q000008:administration & dosage; D011093:Polyethylene Terephthalates; D013211:Staphylococcus aureus / Q000187:drug effects*; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004343:Drug Implants; D011093:Polyethylene Terephthalates; D002440:Cefoxitin; D010068:Oxacillin