Glucocorticoids and head injury. A possible participation of lipocortin (lipomodulin) in actions of the steroid hormones.
The actions of glucocorticoids require the synthesis of new proteins in many, if not all, cases. One such protein that mimics the actions of glucocorticoids has been isolated and characterized as lipocortin. This protein can mimic the anti-inflammatory activity of glucocorticoids by inhibiting phospholipase A2. The effect of glucocorticoids on various stages of brain and spinal cord injury may be partly, although not totally, explained by the activity of lipocortin.
Hirata
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F
Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205.
D017302:Annexins; D006259:Craniocerebral Trauma / Q000503:physiopathology*; D005938:Glucocorticoids / Q000502:physiology*; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D013256:Steroids / Q000502:physiology*
D017302:Annexins; D005938:Glucocorticoids; D006023:Glycoproteins; D013256:Steroids