title: Chemiluminescence in neutrophils and Lettré cells induced by myxoviruses.
abstract: Luminol-mediated chemiluminescence in neutrophils is stimulated by Sendai virus and by influenza virus; Lettré cells also exhibit chemiluminescence (less than 10% of that of neutrophils), which is stimulated by Sendai virus and by influenza virus. Virally induced permeability changes are not responsible for chemiluminescence, since (i) extracellular Ca2+ inhibits permeability changes but stimulates chemiluminescence, and (ii) influenza virus, which induces permeability changes at pH 5.3 but not at pH 7.4, induces chemiluminescence at either pH. Other agents [zymosan, N-formyl-L-methionyl-L-leucyl-L-phenylalanine, 4-phorbol 12-myristate 13-acetate (phorbol ester), A23187] likewise induce chemiluminescence in the absence of permeability changes.
authors.forename: S
authors.initials: S
authors.lastname: Mehta
authors.forename: C L
authors.initials: CL
authors.lastname: Bashford
authors.forename: P
authors.initials: P
authors.lastname: Knox
authors.forename: C A
authors.initials: CA
authors.lastname: Pasternak
mesh_terms: D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002460:Cell Line; D002463:Cell Membrane Permeability / Q000187:drug effects; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D051379:Mice; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D009975:Orthomyxoviridae / Q000502:physiology*; D010222:Parainfluenza Virus 1, Human / Q000502:physiology*
chemical_list: D002118:Calcium