Human B lymphoma cell line producing B cell growth factor.
Namalva, a human B cell lymphoma line, produced a factor with a molecular weight of approximately 60,000 which enhanced the proliferation of normal activated human B lymphocytes. The factor also enhanced the proliferation of certain B cell lines. It can be distinguished physiologically and biochemically from other lymphokines known to enhance B cell proliferation, namely, interleukin (IL) 1, IL 2, and interferon. The production of B cell growth factor by B cell tumor lines may contribute to their ability to grow autonomously and may reflect an important component of the neoplastic potential of the cell. B cell growth factor produced by tumors may also affect normal cells in vivo.
Ambrus
J L
JL
Fauci
A S
AS
D001402:B-Lymphocytes / Q000276:immunology*; D002455:Cell Division; D002460:Cell Line; D002472:Cell Transformation, Viral; D006133:Growth Substances / Q000096:biosynthesis* / Q000302:isolation & purification; D004854:Herpesvirus 4, Human; D006801:Humans; D015847:Interleukin-4; D008222:Lymphokines / Q000096:biosynthesis* / Q000302:isolation & purification; D008970:Molecular Weight
D006133:Growth Substances; D008222:Lymphokines; D015847:Interleukin-4