title: [Medico-genetic study of the population of Kostroma Province. VII. Approaches to the study of the hereditary pathology load in the population of Kostroma].
abstract: Complex medical-genetic study was performed in the center of Kostroma Province with the population of about 250 thousands. A method for ascertainment of patients was developed and the information value of different sources of a registration system available is given. The complete algorithm of calculation of both the segregation frequency and the fraction of sporadic cases for autosomal recessive diseases is presented.
authors.forename: A N
authors.initials: AN
authors.lastname: Petrin
authors.forename: E K
authors.initials: EK
authors.lastname: Ginter
authors.forename: M V
authors.initials: MV
authors.lastname: Khisamova
authors.forename: G I
authors.initials: GI
authors.lastname: El'chinova
authors.forename: A N
authors.initials: AN
authors.lastname: Smirnov
mesh_terms: D000328:Adult; D000465:Algorithms; D002648:Child; D030342:Genetic Diseases, Inborn / Q000453:epidemiology / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D008433:Mathematics; D010375:Pedigree; D010641:Phenotype; D012424:Rural Population; D012426:Russia; D014505:Urban Population
vernacular_title: Mediko-geneticheskoe izuchenie naseleniia Kostromskoĭ oblasti. Soobshchenie VII. Podkhody k izucheniiu otiagoshchennosti nasledstvennoĭ patologieĭ naseleniia Kostromy.