title: [Treatment of erythrodermic and pustulous psoriasis with a combination of methotrexate and etretinate].
abstract: We present herein our experience concerning the use of etretinate and methotrexate as concurrent therapies in three patients with severe psoriasis. On this regimen, rapid clearing of the psoriatic lesions has been achieved in all patients. The efficacy, safety, indications and dosage schedules for this combination therapy are discussed. No significant side effects have been observed in our patients. However, caution must be exercised in the use of this experimental combination regimen, which should only be used in severe psoriasis.
authors.affiliation: Servicio de Dermatología, Hospital Ramón y Cajal, Madrid.
authors.forename: F
authors.initials: F
authors.lastname: Allegue Rodriguez
authors.forename: E
authors.initials: E
authors.lastname: Sendagorta Gomendio
authors.forename: P
authors.initials: P
authors.lastname: Freire Murgueytio
authors.forename: R
authors.initials: R
authors.lastname: Moreno Izquierdo
authors.forename: A
authors.initials: A
authors.lastname: Ledo Pozueta
mesh_terms: D000328:Adult; D003873:Dermatitis, Exfoliative / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005050:Etretinate / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy
chemical_list: D005050:Etretinate; D008727:Methotrexate
vernacular_title: Tratamiento del psoriasis eritrodérmico y pustuloso con terapéutica combinada de metotrexato y etretinato.