Villous adenoma depletion syndrome. Evidence for a cyclic nucleotide-mediated diarrhea.
Massive secretory diarrhea is associated with some villous adenomas. The mechanism of this secretion is unknown but the character of the diarrhea resembles that of cyclic nucleotide-mediated diarrheas. We have compared the cyclic nucleotide metabolism of a large secretory villous adenoma with a nonsecretory villous adenoma, a solid carcinoma and their normal mucosae. The adenylate cyclase, cyclic AMP content, and a cyclic AMP-dependent protein kinase ratios in the secretory tumor were increased as compared to these values in the nonsecretory tumors and normal mucosae, a situation similar to that seen with cholera toxin-induced diarrhea. Our data suggest that the massive diarrhea in our patient with a secretory villous adenoma may be related to increased adenylate cyclase activity.
Jacob
H
H
Schlondorff
D
D
St Onge
G
G
Bernstein
L H
LH
D000230:Adenocarcinoma / Q000378:metabolism; D000236:Adenoma / Q000378:metabolism*; D000262:Adenylyl Cyclases / Q000378:metabolism; D000368:Aged; D000242:Cyclic AMP / Q000378:metabolism; D003967:Diarrhea / Q000209:etiology*; D015237:Dinoprost; D015232:Dinoprostone; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007414:Intestinal Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D009384:Paraneoplastic Endocrine Syndromes / Q000378:metabolism*; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis; D011494:Protein Kinases / Q000378:metabolism; D012811:Sigmoid Neoplasms / Q000378:metabolism
D009712:Nucleotides, Cyclic; D011458:Prostaglandins E; D011460:Prostaglandins F; D015237:Dinoprost; D000242:Cyclic AMP; D011494:Protein Kinases; D000262:Adenylyl Cyclases; D015232:Dinoprostone