[1 percent clindamycin phosphate solution versus 5 percent benzoyl peroxide gel in papulopustular acne].
In a multicenter study, 60 patients suffering from mainly moderate papulopustular acne were treated to pically either with 1% clindamycin phosphate in alcoholic solution or with 5% benzoyl peroxide gel, 30 patients each. During the treatment period of 9 weeks, clinical controls with lesion counts were performed every 3 weeks and after a 3 weeks follow-up. The therapeutic efficacy according to the reduction of papules and pustules was 72% in the benzoyl peroxide group and 73% in the clindamycin group, the latter showing significantly less side effects. On account of its good therapeutic results, we consider topical treatment with clindamycin phosphate an important alternative to systemic antibiotic or topical benzoyl peroxide therapy in acne.
Schmidt
J B
JB
II. Universitäts-Hautklinik Wien.
Neumann
R
R
Fanta
D
D
Raab
W
W
D000152:Acne Vulgaris / Q000188:drug therapy*; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D001585:Benzoyl Peroxide / Q000008:administration & dosage*; D002981:Clindamycin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D010545:Peroxides / Q000008:administration & dosage*; D011897:Random Allocation
D010545:Peroxides; D002981:Clindamycin; C007084:clindamycin phosphate; D001585:Benzoyl Peroxide
1% Clindamycinphosphatlösung versus 5% Benzoylperoxid-Gel bei papulopustulöser Akne.