title: Cytogenetic studies in human T-cell lymphoma virus (HTLV)-positive leukemia-lymphoma in the United States.
abstract: Cytogenetic studies were conducted on fresh and cultured cells from 11 patients with human T-cell leukemia virus-associated adult T-cell leukemia-lymphoma. Clones with abnormal karyotypes were detected in 9 of the 11 patients. Chromosome numbers were near-diploid in cells from all but 1 patient who also had a tetraploid clone. The chromosome abnormalities in these cells were extensive; numerous complex structural changes were seen in every chromosome pair. Structural abnormalities occurred most frequently in chromosome 6. The 6 patients with chromosome 6 deletions had breakpoints at bands q11, q13, q16q23, q21q23, q22q24, and q23q24. The characteristic clinical features of these 6 patients were aggressive course, short survival, poor response to chemotherapy, high white blood cell counts, hypercalcemia, and bone lesions, whereas cytogenetically abnormal patients without chromosome 6q deletions tended to have a more indolent course. The precise role of the 6q deletion cannot be established with certainty from these data. However, this abnormality appears to occur with a greater than expected frequency in this large cell aggressive lymphoma, in association with hypercalcemia and lytic bone lesions.
authors.forename: J
authors.initials: J
authors.lastname: Whang-Peng
authors.forename: P A
authors.initials: PA
authors.lastname: Bunn
authors.forename: T
authors.initials: T
authors.lastname: Knutsen
authors.forename: C S
authors.initials: CS
authors.lastname: Kao-Shan
authors.forename: S
authors.initials: S
authors.lastname: Broder
authors.forename: E S
authors.initials: ES
authors.lastname: Jaffe
authors.forename: E
authors.initials: E
authors.lastname: Gelmann
authors.forename: W
authors.initials: W
authors.lastname: Blattner
authors.forename: W
authors.initials: W
authors.lastname: Lofters
authors.forename: R C
authors.initials: RC
authors.lastname: Young
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D017977:Deltaretrovirus; D005260:Female; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012192:Retroviridae Infections / Q000235:genetics*