[Role opioidergic and adrenergic mechanisms in realizing the pain-alleviating action of clofelin].
It has been demonstrated on unrestrained rats that the analgesic effect of clofelin is primarily determined by the influences on the processes of adrenergic but not opioidergic mediation. The functional heterogeneity of receptor substrates involved in the realization of the hemodynamic (alpha 2-) and emotional-behavioral (alpha 1-) components of the analgesic effect of clofelin is suggested.
Ignatov
Iu D
IuD
Zaĭtsev
A A
AA
D000700:Analgesics; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology*; D004644:Emotions / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011957:Receptors, Opioid / Q000187:drug effects*
D000700:Analgesics; D011941:Receptors, Adrenergic; D011957:Receptors, Opioid; D003000:Clonidine
O roli opioidergicheskikh i adrenergicheskikh mekhanizmov v realizatsii boleutoliaiushchego deĭstviia klofelina.