Predicted protein sequence of the murine I-E-beta S-polypeptide chain from cDNA and genomic clones.
Ia antigens are polymorphic cell-surface glycoprotein complexes, encoded within the I region of the mouse major histocompatibility complex, that control the ability of the organism to mount effective antigen-specific immune responses. We have isolated and determined the nucleotide sequences of cDNA and genomic clones for the I-E beta s gene and we present the predicted protein sequence for most of the E beta s polypeptide chain. The E beta s polypeptide shows 95% protein homology to the other cloned E beta alleles. Comparison of the protein sequences of five E beta alleles from haplotypes that differ in responder phenotype to pigeon cytochrome c suggests that the structure of one of the E beta hypervariable regions may determine responsiveness to this antigen.
Mengle-Gaw
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McDevitt
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D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D010856:Columbidae; D003574:Cytochrome c Group / Q000494:pharmacology; D004247:DNA / Q000235:genetics*; D005796:Genes; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D051379:Mice
D003574:Cytochrome c Group; D000949:Histocompatibility Antigens Class II; D004247:DNA