h-ANF does not play a role in the regulation of myocardial force of contraction.
In the present study, h-ANF failed to reduce myocardial force of contraction alone and in the presence of isoprenaline. This lack of effect was observed in electrically driven, isolated human papillary muscle strips and rat papillary muscles. In contrast, adenosine and carbachol exerted antiadrenergic actions in rat and human myocardium. It is concluded that h-ANF obviously does not play a role in the regulation of human and rat myocardial force of contraction, whereas adenosine and carbachol are capable to produce antiadrenergic effects in the human and rat myocardium.
Böhm
M
M
Medizinische Klinik I, Universität München, Klinikum Grosshadern, F.R.G.
Diet
F
F
Pieske
B
B
Erdmann
E
E
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D002217:Carbachol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects; D013045:Species Specificity
D011976:Receptors, Muscarinic; D009320:Atrial Natriuretic Factor; D002217:Carbachol; D000241:Adenosine; D007545:Isoproterenol