title: Effect of zearalenone on days 7 to 10 postmating on intrauterine environment and migration of embryos in sows.
abstract: On d 7 to 10 postmating, first-litter sows were fed either a control diet or a diet containing zearalenone (ZEN; 1 mg/kg body weight). Surgery was performed on either d 9, 11 or 13 postmating to collect blastocysts and uterine flushings. The rostral and caudal portion of each uterine horn was flushed with phosphate buffered saline, and the blastocysts were separated from the recovered solution. Uterine flushings were analyzed for total Ca, Mg, Zn, estradiol-17 beta (E2 17 beta) and progesterone (P4). Administration of ZEN did not affect the number of blastocysts recovered or the position of embryos within the uterus on d 9 or 11. Blastocysts recovered on d 13 were filamentous and could not be enumerated. Total Ca in uterine flushings of control sows was higher (P less than .001) on d 11 than on d 9 or 13, but intrauterine Ca of ZEN-treated sows did not vary by sampling day (P greater than .05) and was lower (P = .01) than that of controls on d 11. Total intrauterine Mg of ZEN sows was greater (P = .002) than of control sows on d 11 and 13, and total intrauterine Zn of ZEN sows was greater than that in control sows on d 13. There were no differences in total intrauterine P4 or E2 17 beta among ZEN-treated and control sows on d 9, 11 or 13 postmating. Serum concentrations of 13, 14-dihydro-15-ketoprostaglandin F2 alpha (PGFM) increased from d 9 to 13 in control and ZEN-treated sows, but there were no differences between treatment groups.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Purdue University, West Lafayette, IN 47907.
authors.forename: G G
authors.initials: GG
authors.lastname: Long
authors.forename: M A
authors.initials: MA
authors.lastname: Diekman
authors.forename: A B
authors.initials: AB
authors.lastname: Scheidt
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000187:drug effects*; D005260:Female; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D012118:Resorcinols / Q000494:pharmacology*; D013552:Swine / Q000502:physiology*; D014599:Uterus / Q000187:drug effects*; D015025:Zearalenone / Q000494:pharmacology*
chemical_list: D012118:Resorcinols; D015025:Zearalenone