Hyperglycemia in BALB/c mice after pretreatment with one subdiabetogenic dose of streptozotocin and subsequent infection with a Coxsackie B4 strain.
Male BALB/c mice were injected with one subdiabetogenic dose of streptozotocin followed by Coxsackie B4 virus infection 7 days later. The animals developed a transient hyperglycemia after streptozotocin-pretreatment and infection with a human Coxsackie B4 isolate. Frozen sections of pancreata stained with FITC-labeled antibodies showed an intensive infection of the exocrine tissue. Immunofluorescence studies with isolated islets obtained from streptozotocin-treated or untreated animals demonstrated virus antigen in about 20% of the islets 5 days after in vivo virus infection. It is supposed that the hyperglycemia measured in our experiments was caused by a cumulative effect of streptozotocin and virus infection.
Wegner
U
U
Kewitsch
A
A
Madauss
M
M
Döhner
L
L
Zühlke
H
H
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D003384:Coxsackievirus Infections / Q000150:complications*; D003921:Diabetes Mellitus, Experimental / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D029822:Enterovirus B, Human / Q000276:immunology; D006943:Hyperglycemia / Q000209:etiology*; D007515:Islets of Langerhans / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D013311:Streptozocin / Q000008:administration & dosage*
D000956:Antigens, Viral; D013311:Streptozocin