A new criterion for selection of pharmacokinetic multiexponential equations.
In linear pharmacokinetics, the time course of the plasma concentration of a drug, Ct, is expressed by the sum of exponential terms, (formula; see text) This article proposes a new statistical criterion for discriminating between alternate polyexponential models. According to this new criterion, the model that best interprets a set of experimental data points is that which minimizes the area between the approximate confidence limits of Ct.
Imbimbo
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BP
Medical Department, Boehringer Ingelheim Italy, Milan.
Imbimbo
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Daniotti
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Verotta
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Bassotti
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D004317:Doxorubicin / Q000097:blood; D005445:Flunitrazepam / Q000097:blood; D006801:Humans; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000097:blood*; D010599:Pharmacokinetics; D011239:Prednisolone / Q000097:blood; D000198:Spectinomycin / Q000097:blood
D004364:Pharmaceutical Preparations; D005445:Flunitrazepam; D004317:Doxorubicin; D000198:Spectinomycin; D011239:Prednisolone