title: Comparison of ranitidine 300 mg twice daily, 300 mg at night and placebo on 24-hour intragastric acidity of duodenal ulcer patients.
abstract: Continuous measurement of 24-hour intragastric acidity was performed in 12 duodenal ulcer patients in remission during treatment with placebo, ranitidine 300 mg nocte and ranitidine 300 mg b.d. Median 24-hour acidity was 79.4 mmol litre-1 during placebo treatment; it decreased to 28.2 mmol litre-1 during treatment with ranitidine 300 mg nocte and to 3.6 mmol litre-1 during treatment with ranitidine 300 mg b.d. The two regimens decreased intragastric acidity to a similar degree during the night, but significantly greater inhibition of daytime and 24-hour acidity followed use of ranitidine 300 mg b.d.
authors.affiliation: DRK Hospital Mark Brandenburg, Department of Gastroenterology, Berlin, Federal Republic of Germany.
authors.forename: H S
authors.initials: HS
authors.lastname: Merki
authors.forename: L
authors.initials: L
authors.lastname: Witzel
authors.forename: R P
authors.initials: RP
authors.lastname: Walt
authors.forename: J
authors.initials: J
authors.lastname: Neumann
authors.forename: E
authors.initials: E
authors.lastname: Scheurle
authors.forename: D
authors.initials: D
authors.lastname: Kaufmann
authors.forename: A
authors.initials: A
authors.lastname: Mappes
authors.forename: J
authors.initials: J
authors.lastname: Heim
authors.forename: J
authors.initials: J
authors.lastname: Röhmel
mesh_terms: D000328:Adult; D000368:Aged; D002940:Circadian Rhythm; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D006801:Humans; D008297:Male; D008875:Middle Aged; D011899:Ranitidine / Q000627:therapeutic use*
chemical_list: D011899:Ranitidine