A malignant cystosarcoma phyllodes with positive estrogen receptor and its heterotransplantation into nude mice.
We detected cytosol estrogen receptors in a malignant cystosarcoma phyllodes and succeeded in serial transplantations into athymic nude mice. The tumors of this transplantable strain (MC-3-JCK) have the same histologic features as the original tumors, and retain significant amounts of cytosol estrogen receptors. This strain appears to provide a useful experimental model for the study of biologic and therapeutic aspects of human cystosarcoma phyllodes of the breast.
Tokuda
Y
Y
Kubota
M
M
Ueyama
Y
Y
Maruo
K
K
Hata
J
J
Tamaoki
N
N
Tajima
T
T
Mitomi
T
T
D000328:Adult; D000818:Animals; D001943:Breast Neoplasms / Q000032:analysis* / Q000473:pathology; D003600:Cytosol / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D003557:Phyllodes Tumor / Q000032:analysis* / Q000473:pathology; D011960:Receptors, Estrogen / Q000032:analysis*; D014183:Transplantation, Heterologous
D011960:Receptors, Estrogen