Antiviral activity of phorbol myristate acetate and possible relationships with interferon action.
Signal-induced turnover of membrane phospholipids represents a fundamental transducing mechanism that induces a signal cascade resulting in mobilization of calcium, activation of protein kinase C by diacylglycerol, release of arachidonic acid and stimulation of cyclic GMP production. In this pathway tumor-promoting phorbol esters such as phorbol myristate acetate (PMA) may substitute for diacylglycerol. The interferon-like antiviral effect of PMA described here suggests that the inositol phospholipid-diacylglycerol-protein kinase C signal-transducing mechanism may be involved in interferon action.
Premecz
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G
Markovits
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A
Földes
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I
D000998:Antiviral Agents / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D002460:Cell Line; D002472:Cell Transformation, Viral / Q000187:drug effects*; D003588:Cytopathogenic Effect, Viral; D004075:Diglycerides / Q000378:metabolism; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D008563:Membrane Lipids / Q000378:metabolism; D010704:Phorbols / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism; D011247:Pregnancy; D011493:Protein Kinase C; D011494:Protein Kinases / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus
D000998:Antiviral Agents; D004075:Diglycerides; D007370:Interferon Type I; D008563:Membrane Lipids; D010704:Phorbols; D010743:Phospholipids; D011494:Protein Kinases; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate; D002118:Calcium