title: Pro-opiomelanocortin peptides in the human hypothalamus: comparative study between normal subjects and Parkinson patients.
abstract: The concentrations of gamma 3-melanotropin-, alpha-melanotropin-, corticotropin-, gamma-lipotropin- and beta-endorphin-immunoreactivities were determined simultaneously, before and after gel exclusion chromatography, in whole hypothalamic extracts of normal subjects and Parkinson patients. All five immunoreactivities were present and were all significantly correlated to each other. Shorter peptides (alpha-melanotropin, gamma 3-melanotropin, beta-endorphin and a lipotropin37-58-like peptide) were the dominant products. Whereas the dopamine content was significantly reduced in Parkinson patients, there was no significant difference for any peptide between normal subjects and Parkinson patients, either in tissue concentrations or in chromatographic patterns.
authors.forename: L
authors.initials: L
authors.lastname: Pique
authors.forename: S
authors.initials: S
authors.lastname: Jegou
authors.forename: X
authors.initials: X
authors.lastname: Bertagna
authors.forename: F
authors.initials: F
authors.lastname: Javoy-Agid
authors.forename: D
authors.initials: D
authors.lastname: Seurin
authors.forename: M F
authors.initials: MF
authors.lastname: Proeschel
authors.forename: F
authors.initials: F
authors.lastname: Girard
authors.forename: Y
authors.initials: Y
authors.lastname: Agid
authors.forename: H
authors.initials: H
authors.lastname: Vaudry
authors.forename: J P
authors.initials: JP
authors.lastname: Luton
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000368:Aged; D002850:Chromatography, Gel; D004723:Endorphins / Q000032:analysis; D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000032:analysis*; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000032:analysis; D010300:Parkinson Disease / Q000378:metabolism*; D011333:Pro-Opiomelanocortin / Q000032:analysis*; D011863:Radioimmunoassay; D001615:beta-Endorphin; D008083:beta-Lipotropin / Q000032:analysis
chemical_list: D004723:Endorphins; D001615:beta-Endorphin; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D008083:beta-Lipotropin