Functional T cell receptor delta chain gene messages in athymic nude mice.
The rearrangement and expression of T cell antigen receptor (TcR) delta chain genes were investigated in congenitally athymic nude mice. The lymphoid cells derived from nude mice showed evidence of rearranged delta chain genes and a relatively high level of delta chain gene messages. Nucleotide sequence analysis revealed that nude mice contained an in-frame delta chain transcript, composed of V delta 5-D delta 1-D delta 2-J delta 1-C delta genes in the spleen. We have previously described functionally rearranged TcR gamma chain genes in the spleen of nude mice. Taken together, T cell precursors appear to proliferate and differentiate along the extrathymic pathway into TcR gamma/delta-bearing T cells in nude mice.
Yoshikai
Y
Y
Department of Immunology, Kyushu University, Fukuoka, Japan.
Matsuzaki
G
G
Takeda
Y
Y
Ohga
S
S
Kishihara
K
K
Yuuki
H
H
Nomoto
K
K
D000595:Amino Acid Sequence; D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D005796:Genes; D008214:Lymphocytes / Q000502:physiology*; D051379:Mice; D008819:Mice, Nude / Q000235:genetics* / Q000276:immunology; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013950:Thymus Gland / Q000502:physiology
D000945:Antigens, Differentiation, T-Lymphocyte; D012333:RNA, Messenger; D011948:Receptors, Antigen, T-Cell; D016692:Receptors, Antigen, T-Cell, gamma-delta; D004247:DNA