title: Domain preference in iron removal from human transferrin by the bacterial siderophores aerobactin and enterochelin.
abstract: The ability of the siderophores aerobactin and enterochelin to remove iron from transferrin is reported. Aerobactin removes iron from both high-affinity sites on the transferrin molecule, but shows a marked preference for the C-terminal site. This preference is different to that of many iron chelators. Enterochelin removes iron perferentially from the N-terminal site. No evidence for synergism between aerobactin and bidentate ligands could be detected.
authors.affiliation: Department of Biochemistry, University of Leicester, England.
authors.forename: S
authors.initials: S
authors.lastname: Ford
authors.forename: R A
authors.initials: RA
authors.lastname: Cooper
authors.forename: R W
authors.initials: RW
authors.lastname: Evans
authors.forename: R C
authors.initials: RC
authors.lastname: Hider
authors.forename: P H
authors.initials: PH
authors.lastname: Williams
mesh_terms: D001665:Binding Sites; D004754:Enterobacter / Q000378:metabolism; D004758:Enterobactin / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism; D006801:Humans; D006877:Hydroxamic Acids / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000378:metabolism; D007700:Kinetics; D012694:Serine / Q000031:analogs & derivatives*; D014168:Transferrin / Q000378:metabolism*
chemical_list: D006877:Hydroxamic Acids; D007502:Iron Chelating Agents; D014168:Transferrin; C031819:aerobactin; D004758:Enterobactin; D012694:Serine; D007501:Iron