Is hydroxyl radical generated by the Fenton reaction in vivo?
Yeast mutants deficient in activities of cytosolic superoxide dismutase and catalase A and T were exposed to four different kinds of oxygen stress. The response of the cells contradicts suggestions, that hydroxyl radical is formed in vivo through the Fenton reaction. The results suggest that superoxide radicals are directly responsible for cytotoxic effects of oxygen.
Biliński
T
T
Krawiec
Z
Z
Liczmański
A
A
Litwińska
J
J
D002374:Catalase / Q000378:metabolism; D003578:Cytochrome-c Peroxidase / Q000378:metabolism; D006878:Hydroxides / Q000378:metabolism*; D017665:Hydroxyl Radical; D008956:Models, Chemical; D010100:Oxygen; D010269:Paraquat / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D015003:Yeasts / Q000378:metabolism*
D006878:Hydroxides; D017665:Hydroxyl Radical; D003578:Cytochrome-c Peroxidase; D002374:Catalase; D013482:Superoxide Dismutase; D010269:Paraquat; D010100:Oxygen