title: Plasma atrial natriuretic peptide in cardiac transplant recipients. A prospective study.
abstract: Cardiac transplantation in 10 patients with congestive heart failure resulted in reduction of high plasma concentrations of atrial natriuretic peptide (ANP), preoperatively five-fold above normal, to a level two-fold above normal, which was maintained throughout a 12-week follow-up period. Cardiac function was normalized in all patients. Transient increases in plasma ANP, in four cardiac recipients 3-10-fold their basal levels, could neither be related to rejection episodes nor to cardiac dysfunction, but rather to signs of fluid and sodium retention. High plasma ANP levels in cardiac transplant recipients suggest that the capacity to secrete ANP is preserved in the transplanted heart.
authors.affiliation: Unit of Clinical Physiology, Minerva Foundation Institute for Medical Research, Kauniainen, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Forslund
authors.forename: F
authors.initials: F
authors.lastname: Fyhrquist
authors.forename: I
authors.initials: I
authors.lastname: Tikkanen
authors.forename: T
authors.initials: T
authors.lastname: Frøysaker
authors.forename: E
authors.initials: E
authors.lastname: Myhre
authors.forename: F
authors.initials: F
authors.lastname: Riddervold
authors.forename: S
authors.initials: S
authors.lastname: Simonsen
mesh_terms: D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000628:therapy; D016027:Heart Transplantation; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D011446:Prospective Studies; D012083:Renin / Q000097:blood; D014667:Vasopressins / Q000097:blood
chemical_list: D014667:Vasopressins; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin