[Hemoperfusion on charcoal and hemodialysis in acute poisoning caused by methotrexate].
Acute methotrexate intoxication occurred in 4 patients despite adequate alkaline hyperhydration and classical folinic acid rescue. Three of these patients had no previous risk factor. Charcoal haemoperfusion with haemodialysis was promptly instituted and the methotrexate blood levels rapidly decreased, avoiding further renal damage and multisystemic involvement. Chemotherapy could subsequently be performed in 3 of the 4 patients without delay and toxicity. Charcoal haemofiltration appears to be an excellent treatment of methotrexate intoxication.
Frappaz
D
D
Service d'Oncologie pédiatrique, Centre Léon Bérard, Lyon.
Bouffet
E
E
Cochat
P
P
Laville
M
M
Finaz de Vilaine
J
J
Philip
T
T
Biron
P
P
Zanettini
M C
MC
Latour
J F
JF
Gueho
A
A
D000368:Aged; D002606:Charcoal; D002648:Child; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D007677:Kidney Function Tests; D002955:Leucovorin / Q000008:administration & dosage; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000097:blood / Q000506:poisoning* / Q000627:therapeutic use; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*
D002606:Charcoal; D002955:Leucovorin; D008727:Methotrexate
Hémoperfusion sur charbon activé et hémodialyse dans l'intoxication aiguë au méthotrexate.