Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III.
Antibodies from the serum of patients with the acquired immune deficiency syndrome (AIDS) or with the AIDS-related complex and from the serum of seropositive healthy homosexuals, recognize two major glycoproteins in cells infected with human T-cell lymphotropic virus type III (HTLV III). These glycoproteins, gp160 and gp120, are encoded by the 2.5-kilobase open reading frame located in the 3' end of the HTLV-III genome, as determined by amino terminus sequence analysis of the radiolabeled forms of these proteins. It is hypothesized that gp160 and gp120 represent the major species of virus-encoded envelope gene products for HTLV-III.
Allan
J S
JS
Coligan
J E
JE
Barin
F
F
McLane
M F
MF
Sodroski
J G
JG
Rosen
C A
CA
Haseltine
W A
WA
Lee
T H
TH
Essex
M
M
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000595:Amino Acid Sequence; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology*; D001483:Base Sequence; D017977:Deltaretrovirus / Q000276:immunology*; D005814:Genes, Viral; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology; D006801:Humans; D008970:Molecular Weight; D014415:Tunicamycin / Q000494:pharmacology; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D006023:Glycoproteins; D014759:Viral Envelope Proteins; D014415:Tunicamycin