Diminished cerebrospinal fluid beta-endorphin concentration in monkeys with arachnoiditis.
Altered concentrations of brain beta endorphin and spinal cord encephalin have been reported in mice with iatrogenic arachnoiditis. We measured beta-endorphin concentration in cerebrospinal fluid (CSF) in normal monkeys and in monkeys with various degrees of arachnoiditis resulting from myelography and spinal surgery and found a significant negative correlation between the arachnoiditis score and the lumbar CSF beta-endorphin concentration. This study suggests that an assay of CSF beta endorphin can be used to detect the alterations in neurotransmitters in arachnoiditis.
Lipman
B T
BT
Department of Radiology, Medical College of Wisconsin, Milwaukee.
Haughton
V M
VM
D000818:Animals; D001100:Arachnoiditis / Q000134:cerebrospinal fluid*; D008252:Macaca fascicularis; D008255:Macaca radiata; D001615:beta-Endorphin / Q000134:cerebrospinal fluid*
D001615:beta-Endorphin