title: The diurnal variation of immunoreactive adrenocorticotropin in rhesus monkey plasma and cerebrospinal fluid.
abstract: ACTH immunoreactivity (ACTH-IR) in the plasma and cerebrospinal fluid (CSF) collected simultaneously from rhesus monkeys was found to undergo significant diurnal variations. In plasma, the mean peak ACTH-IR was 15.4 +/- 1.95 pg/ml at 0500 h, and the mean minimum concentration was 9.05 +/- 1.80 pg/ml at 1800 h. In CSF, the mean peak ACTH-IR concentration occurred at 1900 h and was 4.64 +/- 0.41 pg/ml. The mean minimum CSF ACTH-IR concentration was 2.93 +/- 0.26 pg/ml, occurring at 0500 h. This is the first report of a diurnal variation in CSF ACTH-IR concentration and is consistent with other work suggesting that plasma ACTH and CSF ACTH originate from different sources.
authors.forename: N H
authors.initials: NH
authors.lastname: Kalin
authors.forename: S E
authors.initials: SE
authors.lastname: Shelton
authors.forename: C M
authors.initials: CM
authors.lastname: Barksdale
authors.forename: M
authors.initials: M
authors.lastname: Carnes
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D000818:Animals; D002940:Circadian Rhythm; D008253:Macaca mulatta; D008297:Male; D011863:Radioimmunoassay
chemical_list: D000324:Adrenocorticotropic Hormone