title: [Multi-year observations of the humoral immunity status of patients with tick-borne encephalitis in 3 endemic regions].
abstract: Analysis of the results of the laboratory diagnosis of tick-borne encephalitis (TBE) by HI test over many years proved a statistically significant decrease by the 80's in the intensity of humoral immunity in the subjects with a history of tick-borne encephalitis in Kemerovo Province, Udmurtia and Latvia. A decrease in antihemagglutinin levels in the blood of convalescents after TBE was detected in endemic foci located in different geographical regions differing by epidemiological parameters; it did not depend on the portion of infected ticks and ratio of the clinical forms of the disease in a focus. Parallel tests by HI of the diagnostic value of several antigens of TBE virus strains isolated from different sources in different regions with sera from TBE patients revealed no differences among them. The antigenic activity of the strains in HI test did not depend on the source and region of isolation (Kemerovo Province, Udmurtia and Latvia).
authors.forename: A S
authors.initials: AS
authors.lastname: Karavanov
authors.forename: G P
authors.initials: GP
authors.lastname: Pivanova
authors.forename: M V
authors.initials: MV
authors.lastname: Bychkova
authors.forename: G G
authors.initials: GG
authors.lastname: Bannova
authors.forename: G Kh
authors.initials: GKh
authors.lastname: Kodkind
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D000918:Antibody Specificity; D004197:Disease Reservoirs; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology; D004675:Encephalitis, Tick-Borne / Q000276:immunology*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007844:Latvia; D011159:Population Surveillance; D012426:Russia; D012800:Siberia
chemical_list: D000914:Antibodies, Viral
vernacular_title: Mnogoletnie nabliudeniia za sostoianiem gumoral'nogo immuniteta u bol'nykh kleshchevym éntsefalitom v trekh éndemichnykh regionakh.