Synthesis and antiviral activity of 11-azapentacyclo[6.2.1.0.0.0]decane.
11-Azapentacyclo[6.2.1.0.0.0]decane (6a) as well as its 6,7-dimethyl derivative 6b was synthesized by a novel, four-step sequence that holds promise for the construction of a variety of cage compounds with bridging nitrogen atoms. The hydrochloride salt of 6a was shown to possess no antiviral activity against either the influenza virus A/Victoria/3/75 or the herpes simplex viruses HSV-1 and HSV-2.
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D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects
D000998:Antiviral Agents; D003517:Cyclopentanes; C045591:11-azapentacyclo(6.2.1).0(2,7).0(4,10).0(5,9)decane