Protection against rotavirus-induced gastroenteritis in a murine model by passively acquired gastrointestinal but not circulating antibodies.
Newborn mice suckled on dams immunized either orally or parenterally with primate rotavirus SA-11 were protected against diarrhea induced by SA-11 virus challenge. Experimental oral administration of milk from orally immunized dams protected suckling mice against challenge; protective activity was detected both in the anti-rotavirus immunoglobulin A (IgA) and IgG fractions, but IgA was more potent in vivo than IgG. Oral administration of milk from parentally immunized dams also protected suckling mice against challenge; in this case, protective activity was detected in the anti-rotavirus IgG fraction. In newborn mice foster-nursed by seronegative dams, circulating rotavirus-specific antibodies in high titer did not protect mice against oral SA-11 virus challenge. It appears that the most effective rotavirus vaccine will be that which induces an efficient production of antibodies active at the intestinal cell surface.
Offit
P A
PA
Clark
H F
HF
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D000833:Animals, Suckling / Q000276:immunology; D003126:Colostrum / Q000276:immunology; D003968:Diarrhea, Infantile / Q000276:immunology* / Q000517:prevention & control; D004064:Digestive System / Q000276:immunology; D004195:Disease Models, Animal; D005759:Gastroenteritis / Q000276:immunology / Q000517:prevention & control*; D007116:Immunization, Passive; D051379:Mice; D008892:Milk / Q000276:immunology; D012401:Rotavirus / Q000276:immunology; D012400:Rotavirus Infections / Q000276:immunology / Q000517:prevention & control*