title: Synthesis of new fluorescent spirolactone derivatives: determination of their affinities for aldosterone receptors.
abstract: Fluorescent spirolactone derivatives are obtained by coupling 3-carboxylic coumarins to a spirolactone bearing a 3-hydroxypropyl chain in the 7 alpha position. The two esters prepared by this method are highly fluorescent (emission 383 and 408 nm).
authors.affiliation: INSERM U 300, Montpellier, France.
authors.forename: G
authors.initials: G
authors.lastname: Auzou
authors.forename: F
authors.initials: F
authors.lastname: Nique
authors.forename: L
authors.initials: L
authors.lastname: Nedelec
mesh_terms: D000450:Aldosterone / Q000378:metabolism*; D005453:Fluorescence; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D018161:Receptors, Mineralocorticoid; D013148:Spironolactone / Q000138:chemical synthesis* / Q000378:metabolism
chemical_list: D011965:Receptors, Glucocorticoid; D018161:Receptors, Mineralocorticoid; D013148:Spironolactone; D000450:Aldosterone