[New lipid biochemical aspects in the pathogenesis of a follicular keratinization disorder in acne vulgaris].
Follicular hyperkeratinization of the epithelium of the acroinfundibulum of sebaceous follicles is one of the primary events in the pathogenesis of acne vulgaris. Oral treatment with 13-cis-retinoic acid can reduce these hyperkeratoses. In order to determine whether follicular hyperkeratinization is related to disturbances of epidermal follicular lipids, we analyzed the lipids of initial comedones from 10 patients with nodulocystic acne before and after a 6th weeks oral therapy with 13-cis-retinoic acid (0.7 mg/kg body weight). The treatment with retinoid resulted in a significant increase of epidermal lipids (free sterols: +34%; ceramides: +19%, whereas the lipids of sebaceous origin decreased (glycerides: -36%). The mass ratio of free sterols to cholesterol sulfate increased by 86% compared to pre-treatment levels. These findings support the hypothesis that local follicular deficiencies of epidermal lipids due to increased sebum secretion might induce abnormal follicular keratinization.
Melnik
B
B
Universitäts-Hautklinik Düsseldorf.
Plewig
G
G
D000152:Acne Vulgaris / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D000328:Adult; D002855:Chromatography, Thin Layer; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D007642:Keratosis / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D012629:Sebum / Q000187:drug effects / Q000378:metabolism
D015474:Isotretinoin
Neue lipidbiochemische Aspekte in der Pathogenese der follikulären Verhornungsstörung bei Acne vulgaris.