Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma.
Epidermal growth factor (EGF) receptor is expressed selectively by human melanoma cells which show the presence of an extra copy of chromosome 7. None of the cells of benign pigmented lesions (nevi) or radial growth phase (nonmetastatic) primary melanoma expressed EGF receptor and none of these cells showed an extra copy of chromosome 7. The results indicate that a single extra dose of a gene (for EGF receptor) may provide a selective advantage to cells in the late stages of tumorigenesis.
Koprowski
H
H
Herlyn
M
M
Balaban
G
G
Parmiter
A
A
Ross
A
A
Nowell
P
P
D000911:Antibodies, Monoclonal; D002460:Cell Line; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D004815:Epidermal Growth Factor / Q000235:genetics* / Q000378:metabolism; D066246:ErbB Receptors; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000378:metabolism; D009362:Neoplasm Metastasis; D009508:Nevus, Pigmented / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism
D000911:Antibodies, Monoclonal; D011956:Receptors, Cell Surface; D004815:Epidermal Growth Factor; D066246:ErbB Receptors