[Effect of 8-Br-cAMP on the formation of conditioned reflex behavior in the white rat].
The influence of cAMP analogue 8-Br-cAMP on conditioning was studied in white rats. Two models of learning were used with different kinds of reinforcement, i. e. conditioned active avoidance and instrumental alimentary reactions in a complex maze. Intraventricular 8-Br-cAMP injection 4 or 24 hours before the beginning of learning improved the process of defensive as well as alimentary conditioning. Characteristics of formation of complex behaviour of experimental rats in a maze showed that under the influence of 8-Br-cAMP, not only conditioning was accelerated, but the process of optimal decision making itself was changed. The data obtained permit to suppose that 8-Br-cAMP first of all affects initially poorly learning rats.
Danilova
R A
RA
Gurevich
E V
EV
Storozheva
Z I
ZI
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D000242:Cyclic AMP / Q000502:physiology; D007276:Injections, Intraventricular; D007858:Learning / Q000502:physiology; D008297:Male; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
D015124:8-Bromo Cyclic Adenosine Monophosphate; D000242:Cyclic AMP
Vliianie 8-Br-cAMP na formirovanie uslovnoreflektornogo povedeniia u belykh krys.