Microbial cleavage of zearalenone.
1. Zearalenone, a fungal oestrogenic compound, was subjected to microbial transformation studies. Preliminary screening with 150 fungal species showed that Gliocladium roseum was capable of metabolizing zearalenone in 80-90% yields. 2. Large-scale fermentation with G. roseum produced a 1:1 mixture of 1-(3,5-dihydroxyphenyl)-10'-hydroxy-1-undecen-6'-one and 1-(3,5-dihydroxyphenyl)-6'-hydroxy-1-undecen-10'-one. The compounds were isolated and purified at -20 degrees C, and identified using spectroscopic analysis and by comparison to products obtained from alkaline hydrolysis of zearalenone.
el-Sharkawy
S
S
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Minnesota, Minneapolis 55455.
Abul-Hajj
Y J
YJ
D000468:Alkalies; D001711:Biotransformation; D005658:Fungi / Q000378:metabolism*; D006868:Hydrolysis; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D003904:Mitosporic Fungi / Q000378:metabolism; D012118:Resorcinols / Q000493:pharmacokinetics*; D015025:Zearalenone / Q000493:pharmacokinetics*
D000468:Alkalies; D012118:Resorcinols; D015025:Zearalenone