title: Regional infusion of fluoropyrimidines for hepatic metastases of colorectal cancer.
abstract: Recent reports on regional chemotherapy for hepatic metastases of colorectal origin are reviewed. Because of reported side effects and lack of evidence for its superiority over conventional intravenous administration, intra-arterial administration of fluoropyrimidines cannot be advised for routine use, but should be restricted to centres participating in clinical trials on this subject.
authors.affiliation: Department of Clinical Pharmacy, General Hospital De Tjongerschans, Heerenveen, The Netherlands.
authors.forename: C H
authors.initials: CH
authors.lastname: Koks
authors.forename: J R
authors.initials: JR
authors.lastname: Brouwers
authors.forename: D T
authors.initials: DT
authors.lastname: Sleijfer
mesh_terms: D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000473:pathology*; D005467:Floxuridine / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D006499:Hepatic Artery; D006801:Humans; D007260:Infusion Pumps; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D011168:Portal System; D012004:Rectal Neoplasms / Q000473:pathology*
chemical_list: D005467:Floxuridine; D005472:Fluorouracil