Effects of acute oral administration of lithium compounds on multiple schedule performance in rats.
Adult male Sprague-Dawley rats were given acute oral administrations of lithium carbonate or lithium chloride at concentrations of 100, 200, and 300 mg/kg. Barpressing performance on a multiple fixed ratio 20/fixed interval 5 minute schedule was measured daily. The 200 and 300 mg/kg administrations of lithium chloride produced significant decreases in barpressing performance and all levels of lithium carbonate produced significant changes in performance. A 24 hour delay in the maximal behavioral effect of the 300 mg/kg dose of lithium carbonate paralleled previous findings showing delays in peak brain lithium levels after oral administration of lithium carbonate.
Chrislip
D W
DW
Anger
W K
WK
Smith
R J
RJ
D000284:Administration, Oral; D000818:Animals; D002712:Chlorides / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D005502:Food; D008027:Light; D008094:Lithium / Q000494:pharmacology*; D016651:Lithium Carbonate; D018021:Lithium Chloride; D008297:Male; D051381:Rats; D012055:Reinforcement Schedule
D002712:Chlorides; D016651:Lithium Carbonate; D008094:Lithium; D018021:Lithium Chloride