Substitution reactions of 99mTcNCl-4--A route to a new class of 99mTc-radiopharmaceuticals.
The preparation of sodium tetrachloronitridotechnetate Na[99mTcNCl4] is described. This complex may be used for the preparation by a substitution route of 99mTc-radiopharmaceuticals containing a Tc-nitrido(TcN) group. The labelling procedure was demonstrated by the preparation of [99mTcN]MDP, [99mTcN]DTPA and [99mTcN]cysteine. Biological distribution studies in mice of these complexes showed that the presence of the nitrido group produced a radiopharmaceutical with different biological behaviour to that produced when conventional reduction methods are used with the same ligand. HPLC studies confirmed that the use of the 99mTcNCl-4 substitution route produced radiopharmaceuticals of high radiochemical purity.
Baldas
J
J
Bonnyman
J
J
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D007553:Isotope Labeling; D051379:Mice; D009584:Nitrogen; D017672:Nitrogen Compounds; D013670:Sodium Pertechnetate Tc 99m; D013667:Technetium; D017556:Technetium Compounds; D014018:Tissue Distribution
D017672:Nitrogen Compounds; D017556:Technetium Compounds; D013667:Technetium; C044788:sodium tetrachloronitrido technetate; D013670:Sodium Pertechnetate Tc 99m; D009584:Nitrogen