Effect of niacin/nicotinamide deficiency on the diabetogenic effect of streptozotocin.
Weanling CD-1 mice were fed either a control diet or a diet deficient in niacin/nicotinamide for one month and then injected i.v. with 60, 80, 100, 120, 140, or 160 mg/kg streptozotocin. Mice on the deficient diet developed a higher incidence of diabetes and more severe hyperglycemia than those on the control diet.
Wright
J R
JR
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
Mendola
J
J
Lacy
P E
PE
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced*; D008297:Male; D051379:Mice; D009525:Niacin / Q000172:deficiency*; D009536:Niacinamide / Q000172:deficiency*; D013311:Streptozocin / Q000008:administration & dosage
D001786:Blood Glucose; D009536:Niacinamide; D009525:Niacin; D013311:Streptozocin