[Growth hormone after baclofen in normal and acromegalic subjects].
Serum growth hormone (GH) levels in basal conditions (two samples) and 30, 60, 90, 120, 150 and 180 minutes after oral administration of baclofen (20 mg) were evaluated in 6 healthy subjects and in 6 acromegalic patients. The effect of cimetidine (400 mg i.v.) administrated 45 minutes after baclofen (20 mg by mouth) were evaluated in 9 healthy women. Baclofen was able to significantly rise serum GH levels in normal subjects but no in acromegalic patients. Cimetidine suppress GH increase induced by baclofen. It was concluded that: 1) baclofen, GABAb receptor agonist, stimulate GH secretion by inhibition of GIF secretion or by stimulation of GRF secretion; 2) istamine, through H2 receptors in the hypothalamus, is important to mediate GH release induced by stimulation of GABAb receptors.
Morosini
P P
PP
Carletti
P
P
Sarzani
R
R
Campanella
N
N
Marchesi
G F
GF
Nardi
B
B
D000172:Acromegaly / Q000503:physiopathology*; D000328:Adult; D001418:Baclofen / Q000494:pharmacology; D002927:Cimetidine; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006632:Histamine / Q000502:physiology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008297:Male; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D011963:Receptors, GABA-A / Q000502:physiology*; D011970:Receptors, Histamine H2 / Q000502:physiology
D011963:Receptors, GABA-A; D011970:Receptors, Histamine H2; D002927:Cimetidine; D006632:Histamine; D013006:Growth Hormone; D001418:Baclofen
Ormone della crescita dopo baclofene in soggetti normali ed acromegalici.