Effect of PSK on the serum level of immunosuppressive substance in splenectomized rats.
Tumor-bearing rats with and without splenectomy were used for an immunological study on the effects of PSK, an immunomodulator, with respect to the survival rate and serum level of immunosuppressive (IS) substance. There was no significant difference in survival rates between the tumor-resected and tumor-resected-plus-splenectomy groups. The IS substance level in the former group was higher than that in the latter group. Normalization of IS substance level and prolongation of survival were observed in the group administered PSK. PSK can be effective in combination with surgical treatment.
Fujii
M
M
Biomedical Research Laboratories, Kureha Chemical Industry Co., Ltd., Tokyo, Japan.
Fujii
T
T
Saito
K
K
Kobayashi
Y
Y
Takahashi
N
N
Yoshikumi
C
C
Taguchi
T
T
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D002279:Carcinoma 256, Walker / Q000276:immunology* / Q000601:surgery / Q000628:therapy; D005260:Female; D007166:Immunosuppressive Agents / Q000097:blood* / Q000494:pharmacology; D008213:Lymphocyte Activation; D011509:Proteoglycans / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013156:Splenectomy
D000903:Antibiotics, Antineoplastic; D007166:Immunosuppressive Agents; D011509:Proteoglycans; C010770:polysaccharide-K