Diurnal variation in the therapeutic efficacy of 5-fluorouracil against murine colon cancer.
Mice bearing the murine colon carcinomas Colon 38 or Colon 26 were treated with 5-fluorouracil (5 FU) (60 or 100 mg/kg, respectively) weekly for 4 weeks at 08.30 hr or at 18.30 hr. The antitumor effect of treatment at 08.30 hr was significantly better for both types of tumors, but most pronounced for Colon 38. Toxicity was evaluated after administration of 60 mg 5 FU/kg. No thrombocytopenia was observed. Leucopenia was observed after treatment at 18.30 hr. It is concluded that the therapeutic efficacy of 5 FU against murine colon cancer is higher when 5 FU is administered at 08.30 hr.
Peters
G J
GJ
Department of Oncology, Free University Hospital, Amsterdam, The Netherlands.
Van Dijk
J
J
Nadal
J C
JC
Van Groeningen
C J
CJ
Lankelma
J
J
Pinedo
H M
HM
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002940:Circadian Rhythm; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity; D007958:Leukocyte Count / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010976:Platelet Count / Q000187:drug effects
D005472:Fluorouracil