title: Are there distinct biochemical subtypes of depression? EEG characteristics of clinically defined on-drug responders and non-responders.
abstract: Subgroups of clinically defined responders and non-responders to clomipramine or maprotiline showed different electroencephalographic dynamics of vigilance, even before pharmacotherapy was initiated. Two hours after the first drug administration subgroup differences no longer existed. On the 21st day of medication we found a tendency towards re-establishing the pre-drug situation. Our findings lend support to the assumption of 'distinct biochemical subtypes' which, however, rather correspond to different stages of the pathophysiological process than represent invariant 'traits'.
authors.affiliation: Department of Clinical Psychiatry, Freie Universität Berlin, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Ulrich
authors.forename: H J
authors.initials: HJ
authors.lastname: Haug
authors.forename: R D
authors.initials: RD
authors.lastname: Stieglitz
authors.forename: E
authors.initials: E
authors.lastname: Fähndrich
mesh_terms: D000328:Adult; D000368:Aged; D000873:Anthracenes / Q000008:administration & dosage*; D001143:Arousal / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects*; D002997:Clomipramine / Q000008:administration & dosage*; D003866:Depressive Disorder / Q000145:classification / Q000188:drug therapy*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008376:Maprotiline / Q000008:administration & dosage*; D008875:Middle Aged
chemical_list: D000873:Anthracenes; D008376:Maprotiline; D002997:Clomipramine