Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells.
T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing alpha and beta T-cell receptor genes isolated from a male-specific, H-2Db-restricted CD4-8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens determines the differentiation of CD4+8+ thymocytes into either CD4+8- or CD4-8+ mature T cells.
Teh
H S
HS
Basel Institute for Immunology, Switzerland.
Kisielow
P
P
Scott
B
B
Kishi
H
H
Uematsu
Y
Y
Blüthmann
H
H
von Boehmer
H
H
D000818:Animals; D000943:Antigens, Differentiation; D002454:Cell Differentiation; D005260:Female; D006183:H-2 Antigens; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D011948:Receptors, Antigen, T-Cell; D012641:Selection, Genetic; D013601:T-Lymphocytes / Q000502:physiology*; D006377:T-Lymphocytes, Helper-Inducer; D050378:T-Lymphocytes, Regulatory
D000943:Antigens, Differentiation; D006183:H-2 Antigens; D011948:Receptors, Antigen, T-Cell