Immunohistology of rheumatoid nodules and rheumatoid synovium.
The immunohistological features of rheumatoid nodules and rheumatoid synovium were examined using monoclonal and polyclonal antibodies raised against macrophages, HLA-DR, leucocyte common antigen, and immunoglobulin components. The palisading cells surrounding the necrotic centre of the rheumatoid nodule were shown to be HLA-DR positive leucocytes, mostly histiocytes. The inflammatory infiltrate associated with rheumatoid nodules showed many immunohistochemical similarities to that of rheumatoid synovium, including a preponderance of IgG positive plasma cells, and a similar number and microanatomical pattern of distribution of HLA-DR positive cells. The significance of these findings for the cellular immunopathology and aetiology of the rheumatoid lesion is discussed.
Athanasou
N A
NA
Nuffield Department of Pathology, University of Oxford, John Radcliffe Hospital.
Quinn
J
J
Woods
C G
CG
Mcgee
J O
JO
D000943:Antigens, Differentiation / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000473:pathology*; D006684:HLA-DR Antigens / Q000032:analysis; D006649:Histocompatibility Antigens / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D017493:Leukocyte Common Antigens; D007962:Leukocytes / Q000473:pathology; D012218:Rheumatoid Nodule / Q000276:immunology / Q000473:pathology*; D013583:Synovial Membrane / Q000276:immunology / Q000473:pathology*
D000943:Antigens, Differentiation; D006684:HLA-DR Antigens; D006649:Histocompatibility Antigens; D017493:Leukocyte Common Antigens