[Myocardial reaction of the right ventricle to lung resection].
Right-sided pulmonectomy (resection of 63-65% of the lung parenchyma) in white noninbred rats resulted in development of chronic cor pulmonale, that develops according to the stages: I--from the time of the operation up to the 10th-15th days after the operation--the stage of acute disturbances and mobilization forces of the organism; II--from the 11th-15th up to the 90th day is the stage of a relative steady compensatory hypertrophy of the cardiac right ventricle; III--after the 90th day--the stage of decompensation. The hypertrophy of the right ventricle myocardium transfers into its dilatation. Amount of cardiomyocytes and their nuclei in 1 mg of the right ventricle tissue progressively decreases, quantity of multinuclear cardiomyocytes increases, ploidy of the nuclei changes: number of tetraploid nuclei decreases, octaploid nuclei appear. Lethality among the animals is 56%.
Bilich
G L
GL
Kiselev
A A
AA
Puzikov
A O
AO
D000818:Animals; D006332:Cardiomegaly / Q000209:etiology / Q000473:pathology; D002452:Cell Count; D006352:Heart Ventricles / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D011003:Ploidies; D011013:Pneumonectomy / Q000009:adverse effects; D011183:Postoperative Complications / Q000473:pathology; D051381:Rats; D013997:Time Factors
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