Polyglucosan bodies in the sural nerve of a diabetic patient with polyneuropathy.
In the sural nerve of a 62-year-old woman with impaired glucose tolerance test and polyneuropathy, many intra-axonal polyglucosan bodies were observed. Polyglucosan bodies have been described in spontaneously or alloxan-diabetic rats, but are not usually observed in human diabetic neuropathy. Since intra-axonal polyglucosan bodies can occur in the sural nerve in various diseases and in aging, they are considered as non-specific changes. Their presence is probably related to a primary axonal neuropathy.
Mancardi
G L
GL
Schenone
A
A
Tabaton
M
M
Tassinari
T
T
Mainardi
P
P
D001369:Axons / Q000648:ultrastructure; D001706:Biopsy; D003929:Diabetic Neuropathies / Q000473:pathology*; D005260:Female; D005936:Glucans / Q000378:metabolism*; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008875:Middle Aged; D009133:Muscular Atrophy / Q000473:pathology; D009186:Myelin Sheath / Q000648:ultrastructure; D013127:Spinal Nerves / Q000473:pathology*; D013497:Sural Nerve / Q000473:pathology*
D005936:Glucans