trans-Activation of the human T-cell leukemia virus long terminal repeat correlates with expression of the x-lor protein.
Cell lines established directly from adult T-cell leukemia-lymphoma patients or immortalized by human T-cell leukemia virus type I (HTLV-I) in vitro that do not produce complete HTLV virions were characterized both for the content of viral proteins and for the presence of trans-acting factors activating gene expression under the control of the HTLV long terminal repeat. The expression of the 42-kilodalton HTLV x-lor product correlated with trans-activation of the long terminal repeat. The implications of this study for understanding the role of the HTLV x-lor product in the initiation and maintenance of T-lymphocyte transformation are discussed.
Sodroski
J G
JG
Goh
W C
WC
Rosen
C A
CA
Salahuddin
S Z
SZ
Aldovini
A
A
Franchini
G
G
Wong-Staal
F
F
Gallo
R C
RC
Sugamura
K
K
Hinuma
Y
Y
D017977:Deltaretrovirus / Q000235:genetics*; D005786:Gene Expression Regulation; D014764:Viral Proteins / Q000235:genetics*
D014764:Viral Proteins