title: Granulocyte activating factor released from Propionibacterium acnes. A possible mediator of inflammation in acne vulgaris.
abstract: Incubation of Propionibacterium acnes but not of Propionibacterium granulosum or Propionibacterium avidum (for 30 min at 37 degrees C in physiological saline) released a soluble factor that produced enhanced chemiluminescence response of human granulocytes as well as increased chemotactic motility of these cells. Sephadex G-25 filtration of the granulocyte activating factor (GAF) revealed its low molecular weight and apparent peptide character. Thus, GAF may be a stimulus for inflammation in acne vulgaris since low molecular weight chemotactic factors can be expected to penetrate follicular walls.
authors.affiliation: Hygiene-Institut der Universität zu Köln.
authors.forename: G
authors.initials: G
authors.lastname: Pulverer
authors.forename: W
authors.initials: W
authors.lastname: Roszkowski
authors.forename: H J
authors.initials: HJ
authors.lastname: Beuth
authors.forename: H L
authors.initials: HL
authors.lastname: Ko
authors.forename: P
authors.initials: P
authors.lastname: Quie
mesh_terms: D000152:Acne Vulgaris / Q000209:etiology* / Q000473:pathology; D002634:Chemotaxis, Leukocyte; D002850:Chromatography, Gel; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007249:Inflammation; D007700:Kinetics; D008163:Luminescent Measurements; D008970:Molecular Weight; D010455:Peptides / Q000032:analysis / Q000276:immunology* / Q000378:metabolism; D011425:Propionibacterium acnes / Q000276:immunology*
chemical_list: D010455:Peptides