Improved left ventricular function after short-term treatment with fructose-1,6-diphosphate: echocardiographic study in chronic ischemic heart disease and idiopathic dilated cardiomyopathy.
The effect of fructose-1,6-diphosphate (FDP) on left ventricular function was assessed in seven patients with chronic ischemic heart disease and eight patients with idiopathic dilated cardiomyopathy. In a crossover study design each patient received 10 gm of FDP or saline placebo intravenously for three days. An M-mode echocardiographic assessment of left ventricular (LV) function was made before and after each treatment period. After FDP treatment, LV end-diastolic and systolic dimensions showed a 6% reduction (P less than 0.01), while peak lengthening rate of LV dimension in diastole and peak shortening rate of LV dimension in systole increased 17% and 10%, respectively (P less than 0.05). There was evidence that FDP was more effective in the patients with ischemic heart disease than in the patients with cardiomyopathy.
Grandi
A M
AM
Department of Internal Medicine and Medical Therapeutics, University of Pavia-IRCCS, Italy.
Muggia
C
C
Barzizza
F
F
Venco
A
A
Finardi
G
G
D000368:Aged; D006332:Cardiomegaly / Q000188:drug therapy; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy / Q000503:physiopathology; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology; D004452:Echocardiography; D005260:Female; D005635:Fructosediphosphates / Q000494:pharmacology / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D006598:Hexosediphosphates / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged
D005635:Fructosediphosphates; D006598:Hexosediphosphates; C029063:fructose-1,6-diphosphate