Elevated soluble interleukin-2 receptor levels in serum of human immunodeficiency virus infected populations.
Soluble interleukin-2 receptor (SIL-2R) levels in sera were quantitated in asymptomatic intravenous drug abusers (IVDA) and in patients with lymphadenopathy or AIDS. The mean SIL-2R level in serum of normal controls was 158 +/- 19 compared to 368 +/- 35 U/ml in serum of HIV-seronegative asymptomatic IVDA. The mean SIL-2R in serum of HIV-seropositive asymptomatic IVDA was 609 +/- 85 U/ml and in patients with lymphadenopathy was 745 +/- 79 U/ml. In addition, AIDS patients with Pneumocystis carinii pneumonia, Kaposi's sarcoma, or both had elevated mean levels of SIL-2R values with a broad range. This elevated level of SIL-2R may reflect excessive cell surface IL-2R expansion by the infected cells.
Reddy
M M
MM
R.A. Cooke Institute of Allergy, St. Luke's/Roosevelt Hospital Center, New York, NY.
Grieco
M H
MH
D000386:AIDS-Related Complex / Q000097:blood; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood*; D006679:HIV Seropositivity / Q000097:blood*; D006801:Humans; D007958:Leukocyte Count; D011971:Receptors, Immunologic / Q000378:metabolism*; D015375:Receptors, Interleukin-2; D019966:Substance-Related Disorders / Q000097:blood; D006377:T-Lymphocytes, Helper-Inducer; D050378:T-Lymphocytes, Regulatory
D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2