title: Synthesis of N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline (lisinopril).
abstract: The synthesis and some of the spectral properties of N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline (lisinopril, MK-521) are described. This compound inhibits angiotensin-converting enzyme with an IC50 of 1.2 X 10(-9) M.
authors.forename: M T
authors.initials: MT
authors.lastname: Wu
authors.forename: A W
authors.initials: AW
authors.lastname: Douglas
authors.forename: D L
authors.initials: DL
authors.lastname: Ondeyka
authors.forename: L G
authors.initials: LG
authors.lastname: Payne
authors.forename: T J
authors.initials: TJ
authors.lastname: Ikeler
authors.forename: H
authors.initials: H
authors.lastname: Joshua
authors.forename: A A
authors.initials: AA
authors.lastname: Patchett
mesh_terms: D002247:Carbon Isotopes; D055598:Chemical Phenomena; D002621:Chemistry; D004151:Dipeptides / Q000138:chemical synthesis*; D017706:Lisinopril; D009682:Magnetic Resonance Spectroscopy
chemical_list: D002247:Carbon Isotopes; D004151:Dipeptides; D017706:Lisinopril