title: Regional cerebral glucose metabolism in anxiety disorders studied with positron emission tomography before and after psychosurgical intervention. A preliminary report.
abstract: Regional cerebral metabolic rate of glucose (rCMRGl) was studied with positron emission tomography in patients suffering from severe anxiety disorders undergoing capsulotomy, an anti-anxiety psychosurgical intervention in which fronto-limbic connections are interrupted. Preliminary observations on five patients show a statistically significant reduction in rCMRGl postoperatively in the orbitomedial frontal cortex, a region knonw to be of relevance for the capsulotomy effects. Clinically, 4 of 5 patients improved after surgery. The study may provide new information on the pathophysiology of anxiety.
authors.affiliation: Department of Psychiatry, Karolinska Sjukhuset, Stockholm, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Mindus
authors.forename: K
authors.initials: K
authors.lastname: Ericson
authors.forename: T
authors.initials: T
authors.lastname: Greitz
authors.forename: B A
authors.initials: BA
authors.lastname: Meyerson
authors.forename: H
authors.initials: H
authors.lastname: Nyman
authors.forename: I
authors.initials: I
authors.lastname: Sjögren
mesh_terms: D000328:Adult; D001007:Anxiety / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000601:surgery; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011612:Psychosurgery; D014055:Tomography, Emission-Computed
chemical_list: D005947:Glucose