title: In-vitro activity of enoxacin against gonococcal isolates in comparison with that of five other antibiotics.
abstract: The in-vitro activity of enoxacin was investigated against 305 clinical isolates of Neisseria gonorrhoeae, including both penicillinase-producing strains (PPNG) and non-penicillinase producing strains (NPPNG), and compared with the activity of cefuroxime, acrosoxacin, spectinomycin, benzylpenicillin and ampicillin. Enoxacin was more active than the other antimicrobials tested, with an MIC90 value for the NPPNG organisms of 0.08 mg/l and for the PPNG organisms of 0.16 mg/l. Ten of the 305 isolates tested were resistant to spectinomycin; MICs of less than or equal to 0.08 mg/l were obtained for enoxacin against these organisms.
authors.affiliation: Gonococcus Reference Unit, Public Health Laboratory, Bristol, UK.
authors.forename: A E
authors.initials: AE
authors.lastname: Jephcott
authors.forename: K
authors.initials: K
authors.lastname: Gough
mesh_terms: D042462:4-Quinolones; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002444:Cefuroxime / Q000494:pharmacology; D015365:Enoxacin; D006801:Humans; D009287:Naphthyridines / Q000494:pharmacology*; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000201:enzymology; D010400:Penicillin G / Q000494:pharmacology; D010405:Penicillinase / Q000096:biosynthesis; D011804:Quinolines / Q000494:pharmacology; D015363:Quinolones; D000198:Spectinomycin / Q000494:pharmacology
chemical_list: D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D009287:Naphthyridines; D011804:Quinolines; D015363:Quinolones; D015365:Enoxacin; C021083:rosoxacin; D000667:Ampicillin; D000198:Spectinomycin; D010405:Penicillinase; D002444:Cefuroxime; D010400:Penicillin G