Susceptibility to erbB-induced erythroblastosis is a dominant trait of 151 chickens.
Rous-associated virus-1 (RAV-1)-induced erythroblastosis results from proviral insertions into or viral transductions of the c-erbB region of the epidermal growth factor gene. Most chickens develop low incidences (less than 5%) of RAV-1-induced erythroblastosis. However, an inbred line of chickens (151) suffers high incidences (approximately 80%) of RAV-1-induced erythroblastosis. Analysis of 151, K28, and (K28 X 151) X K28 chickens for susceptibility to RAV-1-induced erythroblastosis revealed that susceptibility to RAV-1-induced erythroblastosis is a dominant trait of line 151 chickens. Analysis of 151 X K28 and K28 chicks for susceptibility to the induction of erythroblastosis by two new c-erbB-transducing viruses (avian erythroblastosis virus strains AEV-5005 and AEV-5009) revealed that susceptibility to transformation by new c-erbB-transducing viruses is also a dominant trait of 151 chickens. We think it is likely that both of these dominant traits are encoded by the same gene or genes. Our hypothesis is that this gene (or genes) potentiates the ability of the transmembrane and cytoplasmic domains of the epidermal growth factor receptor to transform cells.
Robinson
H L
HL
Miles
B D
BD
Catalano
D E
DE
Briles
W E
WE
Crittenden
L B
LB
D001355:Alpharetrovirus / Q000235:genetics; D000818:Animals; D001353:Avian Leukosis / Q000276:immunology*; D002472:Cell Transformation, Viral; D002645:Chickens / Q000276:immunology*; D066246:ErbB Receptors; D005799:Genes, Dominant; D011956:Receptors, Cell Surface / Q000235:genetics
D011956:Receptors, Cell Surface; D066246:ErbB Receptors