[Morphometric study on sensitization by hematoporphyrin derivative in Ehrlich ascites tumor cells irradiated by gamma-ray].
In this paper, light and electron micrographs of Ehrlich ascites tumor cells radiated by gamma-ray and influenced by hematoporphyrin derivative (HPD) were analysed by morphometric method. It was found that in these cells, the domain of microfilaments treated by HPD expanded extensively, which enhanced the damage of cells induced by gamma-ray. Twenty five minutes after radiation, the cellular fragments increased, resulting in a decrease in the mean diameter of cells and an increase of nuclear volume density and nucleocytoplasmic ratio. In addition, ribosomes on the rough endoplasmic reticulum surfaces fell off increasingly and the quantity of smooth endoplasmic reticula increased.
Lu
M
M
Beijing Medical University.
Zheng
F
F
Huang
H N
HN
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor; D002467:Cell Nucleus / Q000528:radiation effects; D005720:Gamma Rays; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000494:pharmacology*; D066298:In Vitro Techniques; D051379:Mice; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000528:radiation effects
D006415:Hematoporphyrins; D011838:Radiation-Sensitizing Agents; D017324:Hematoporphyrin Derivative