title: Perinatal factors, periventricular haemorrhage and mortality in very low birthweight infants.
abstract: In a population of 225 very low birthweight infants born over a 21 month period the cerebroventricular system was scanned by ultrasound. One third of the infants developed a periventricular haemorrhage; in 41% of infants the haemorrhage was detected before an hour of age and 66% of all haemorrhages occurred within the first 24 hours. Statistically significant associations with periventricular haemorrhage included vaginal delivery, endotracheal intubation and intravenous sodium bicarbonate when this was administered in the first 24 hours. In a stepwise regression analysis, however, these and other potentially significant variables added little to the total accountable variance. A similar analysis of perinatal factors and mortality revealed that decreasing gestation was the major association with death.
authors.forename: L J
authors.initials: LJ
authors.lastname: Murton
authors.forename: W W
authors.initials: WW
authors.lastname: Butt
authors.forename: R J
authors.initials: RJ
authors.lastname: Mackay
authors.forename: R N
authors.initials: RN
authors.lastname: Roy
authors.forename: L C
authors.initials: LC
authors.lastname: De Crespigny
mesh_terms: D001639:Bicarbonates / Q000008:administration & dosage / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000150:complications / Q000453:epidemiology; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007442:Intubation, Intratracheal; D008297:Male; D011247:Pregnancy; D017693:Sodium Bicarbonate; D014463:Ultrasonography
chemical_list: D001639:Bicarbonates; D017693:Sodium Bicarbonate