Comparative anatomo-functional imaging of two neuroreceptors and glucose metabolism: a PET study performed in the living baboon.
Regional specialization of two types of neuroreceptor--opiate and dopamine--was mapped by positron emission tomography (PET) in the subcortical gray matter of the living baboon and analyzed in comparison with glucose metabolism. The three radiopharmaceuticals used--[18F]3-acetylcyclofoxy, [11C]3-N-methylspiperone, and [18F]2-fluoro-2-deoxyglucose--traced opiate- and dopamine-receptor distribution and regional glucose metabolism, respectively. A combination of high spatial resolution (6-7 mm) and the intrinsic sensitivity of the PET method made possible the detection of nanomolar concentrations of neuroreceptors and micromolar concentrations of metabolized glucose, with different and distinctive anatomo-functional distributions in thalami and basal ganglia.
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D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002250:Carbon Radioisotopes; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005461:Fluorine; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009271:Naltrexone / Q000031:analogs & derivatives; D010215:Papio; D011868:Radioisotopes; D011954:Receptors, Dopamine / Q000302:isolation & purification / Q000378:metabolism*; D011957:Receptors, Opioid / Q000302:isolation & purification / Q000378:metabolism*; D013134:Spiperone / Q000031:analogs & derivatives; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D011868:Radioisotopes; D011954:Receptors, Dopamine; D011957:Receptors, Opioid; D019788:Fluorodeoxyglucose F18; D005461:Fluorine; D013134:Spiperone; D009271:Naltrexone; C039167:3-N-methylspiperone; C043394:3-acetyl-6-deoxy-6-fluoronaltrexone; D003847:Deoxyglucose; D005947:Glucose