title: Effects of iopentol, iohexol and metrizoate on the contractility of the isolated rabbit heart.
abstract: Fifteen isolated rabbit hearts were perfused with Krebs' solution according to the Langendorff technique. Before, during, and after perfusion of the heart with iopentol, iohexol and metrizoate at doses 1 ml, 2 ml and 4 ml (350 mg I/ml), ECG and left ventricular contractile force were registered. The contractile force was measured with a strain gauge sutured to the wall of the left ventricle. At each dose 12 perfusions were made. At each dose iohexol and iopentol produced a smaller decrease in contractile force than metrizoate (p less than 0.001). There was no difference in effect on contractile force between iohexol and iopentol.
authors.affiliation: Department of Diagnostic Radiology, Malmö Allmänna Sjukhus, University of Lund, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Almén
authors.forename: L
authors.initials: L
authors.lastname: Bååth
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007472:Iohexol / Q000494:pharmacology; D008297:Male; D008794:Metrizoic Acid / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects*; D011817:Rabbits; D014283:Triiodobenzoic Acids / Q000494:pharmacology
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C053571:iopentol; D008794:Metrizoic Acid