title: The Diagnostic Melancholia Scale (DMS): dimensions of endogenous and reactive depression with relationship to the Newcastle Scales.
abstract: The two diagnostic Newcastle Scales for depression have been evaluated in a drug trial with antidepressants. By use of latent structure analysis (Rasch models) it was found that two dimensions are necessary for describing the diagnosis of depression, one for endogenous features and one for reactive features. Of the depressed patients 50% had a pure endogenous depression, 14% had a pure reactive depression, 32% had mixed endogenous and reactive depression, and 4% had uncertain diagnosis. In the pure endogenous depression group 77% had a monotonically non-decreasing improvement curve during treatment whereas in the other diagnostic categories around 50% had such an improvement.
authors.affiliation: Frederiksborg General Hospital, Hillerød, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Bech
authors.forename: P
authors.initials: P
authors.lastname: Allerup
authors.forename: L F
authors.initials: LF
authors.lastname: Gram
authors.forename: P
authors.initials: P
authors.lastname: Kragh-Sørensen
authors.forename: O J
authors.initials: OJ
authors.lastname: Rafaelsen
authors.forename: N
authors.initials: N
authors.lastname: Reisby
authors.forename: P
authors.initials: P
authors.lastname: Vestergaard
mesh_terms: D000275:Adjustment Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D015283:Citalopram; D002986:Clinical Trials as Topic; D002997:Clomipramine / Q000627:therapeutic use; D003866:Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011437:Propylamines / Q000627:therapeutic use; D011581:Psychological Tests; D011594:Psychometrics
chemical_list: D000928:Antidepressive Agents; D011437:Propylamines; D015283:Citalopram; D002997:Clomipramine