title: Selective injection of iopentol, iohexol and metrizoate into the left coronary artery of the dog. Induction of ventricular fibrillation and decrease of aortic pressure.
abstract: In twenty beagle dogs selective injections were made into the left coronary artery with iopentol, iohexol and metrizoate in doses of 4 ml, 8 ml and 16 ml. Thirty-six iopentol injections, 35 iohexol injections and 37 metrizoate injections were made. Frequencies of ventricular fibrillation were significantly lower (p less than 0.05) after iopentol (0%) and iohexol (3%) than after metrizoate (22%). Iopentol and iohexol also produced significantly less decrease in aortic blood pressure than metrizoate at the different doses.
authors.affiliation: Department of Diagnostic Radiology, Malmö Allmänna Sjukhus, University of Lund, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Almén
authors.forename: L
authors.initials: L
authors.lastname: Bååth
mesh_terms: D000818:Animals; D001011:Aorta / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects*; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D017023:Coronary Angiography; D004285:Dogs; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D007267:Injections; D007472:Iohexol / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008794:Metrizoic Acid / Q000008:administration & dosage / Q000009:adverse effects; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000009:adverse effects; D014693:Ventricular Fibrillation / Q000139:chemically induced*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C053571:iopentol; D008794:Metrizoic Acid