Increased glial fibrillary acidic protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus.
Glial fibrillary acidic protein (GFAP) increases in astrocytes following axotomy of facial motoneurons. In the present study we quantified GFAP synthesis both in regenerating facial nuclei after nerve crush and in nonregenerating facial nuclei after nerve resection. An increase in GFAP synthesis during regeneration occurs as early as 24 h after the axotomy. Thus, the increase in the astrocytic GFAP synthesis seems to be the earliest glial response to retrograde changes in facial motoneurons.
Tetzlaff
W
W
Department of Medical Physiology, University of Calgary, Alberta, Canada.
Graeber
M B
MB
Bisby
M A
MA
Kreutzberg
G W
GW
D000818:Animals; D001253:Astrocytes / Q000378:metabolism* / Q000502:physiology; D005154:Facial Nerve / Q000502:physiology*; D005904:Glial Fibrillary Acidic Protein / Q000096:biosynthesis* / Q000502:physiology; D009046:Motor Neurons / Q000502:physiology*; D009416:Nerve Regeneration; D051381:Rats; D013997:Time Factors
D005904:Glial Fibrillary Acidic Protein