The zoapatle. VI. Revisited.
A review of new Zoapatle publications was made, including five chemical compounds characterized recently. Relative potency of Kaurenoic acid, Kauradienoic acid (its mixture), Zoapatanol and Montanol was estimated in an in vitro guinea pig uterine assay. Kaurene compounds were several times more potent than Montanol and Zoapatanol as uteroactive substances. Zoapatle aqueous crude extract made from Montanoa frutescens had a strong in vitro uterine potency and unique in vivo characteristics in several biological systems, described in detail in the following five publications.
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D000020:Abortifacient Agents, Nonsteroidal / Q000494:pharmacology; D000028:Abortion, Induced; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects; D002584:Cervix Uteri / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D003271:Contraceptive Agents, Female / Q000494:pharmacology; D003338:Corpus Luteum / Q000187:drug effects; D006224:Cricetinae; D004285:Dogs; D004717:Endometrium / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D000882:Haplorhini; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007751:Labor, Induced; D008297:Male; D051379:Mice; D035924:Montanoa; D010082:Oxepins / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis / Q000648:ultrastructure; D011247:Pregnancy; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects; D013078:Sperm Immobilizing Agents / Q000494:pharmacology; D013094:Spermatozoa / Q000187:drug effects; D013329:Structure-Activity Relationship; D014590:Uterine Contraction / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D000020:Abortifacient Agents, Nonsteroidal; D003271:Contraceptive Agents, Female; D010082:Oxepins; D010936:Plant Extracts; D011956:Receptors, Cell Surface; D013078:Sperm Immobilizing Agents; D014662:Vasoconstrictor Agents; C442248:zoapatanol