Murine in vitro antigenic modification of tumor cells: effect on susceptibility to natural cell-mediated cytotoxicity.
A 3-methylcholanthrene [(MCA) CAS: 56-49-5]-induced fibrosarcoma cell line and its Friend murine leukemia virus-infected counterpart were assessed for their susceptibility to lysis by so-called "natural" effector cells in a series of 51Cr release assays. Detailed functional and phenotypic analysis of lytic effector cell populations from normal C57BL/6 mouse spleens revealed an identity most closely associated with natural cytotoxic cells. Neither tumor cell line was found to be sensitive to natural killer-mediated lysis. Additionally, virus infection of the MCA-induced fibrosarcoma cell line did not affect susceptibility to natural cell-mediated cytotoxicity.
Langweiler
M
M
Weinhold
K J
KJ
Matthews
T J
TJ
Bolognesi
D P
DP
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology; D002241:Carbohydrates / Q000494:pharmacology; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology; D007694:Killer Cells, Natural / Q000276:immunology*; D009052:Leukemia Virus, Murine / Q000276:immunology; D008748:Methylcholanthrene; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000473:pathology*; D013154:Spleen / Q000276:immunology
D000954:Antigens, Surface; D000956:Antigens, Viral; D002241:Carbohydrates; D008748:Methylcholanthrene