Isolation and evaluation of target cells in glaucoma research: hormone receptors and drug responses.
To investigate the actions of drugs and hormones which influence intraocular pressure (IOP), we have been measuring receptor binding characteristics and dose-response effects using individual target cells from the anterior segment. Similar methods have also permitted us to develop sensitive radio-receptor assays for glucocorticoids and beta adrenergic antagonists. These methods provide a means to obtain new and potentially useful information regarding the efficacy and specificity of ocular drug therapy.
Polansky
J R
JR
Alvarado
J A
JA
D000818:Animals; D002417:Cattle; D002460:Cell Line; D002478:Cells, Cultured; D002924:Ciliary Body / Q000166:cytology; D004847:Epithelial Cells; D005901:Glaucoma / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D009132:Muscles / Q000378:metabolism; D010277:Parasympathomimetics / Q000494:pharmacology; D011323:Primates; D011869:Radioligand Assay; D011941:Receptors, Adrenergic / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D013566:Sympathomimetics / Q000494:pharmacology; D014129:Trabecular Meshwork / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
D010277:Parasympathomimetics; D011941:Receptors, Adrenergic; D011956:Receptors, Cell Surface; D011950:Receptors, Cholinergic; D011965:Receptors, Glucocorticoid; D013566:Sympathomimetics