The role of soluble acids from oxidative-hydrolytic breakdown of coal in the development of the fibrous process in anthracosis.
The oxidative-hydrolytic mechanism of interaction of coal with tissue medium and the formation of humic acids (HA) and polycarboxylic acids (PCA) from coal in the organism were demonstrated. The composition of PCA obtained from the coal withdrawn from the organism of animals was investigated by gas-liquid chromatography by means of which 28 acids of the aromatic series were identified. The method of elemental spectral analysis revealed the transition of a number of macro- and microelements into the medium of the organism. It has been shown experimentally that the decrease in the mass of coal correlates with the fibrogenic process. The conclusion has been drawn that the soluble products of the oxidative-hydrolytic breakdown of coal in the organism are among the fibrogenic factors of pneumosclerosis in anthracosis. The initial mechanism in the development of fibrosis is the damage caused by polycarboxylic acids to the microcirculatory bed of the lungs and the structures of the aerohematic barrier.
Kukharenko
T A
TA
Medical Institute, Karaganda, USSR.
Dinkelis
S S
SS
Yershova
N N
NN
Shkutin
A E
AE
D000818:Animals; D000874:Anthracosilicosis / Q000209:etiology* / Q000473:pathology; D002264:Carboxylic Acids / Q000032:analysis; D003031:Coal / Q000009:adverse effects* / Q000032:analysis; D006812:Humic Substances / Q000032:analysis; D006868:Hydrolysis; D010084:Oxidation-Reduction; D011658:Pulmonary Fibrosis / Q000209:etiology / Q000473:pathology; D051381:Rats; D012995:Solubility
D002264:Carboxylic Acids; D003031:Coal; D006812:Humic Substances