title: Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5.
abstract: The binding sites for the 300-, 107-, and 105-kilodalton cellular proteins which associate with human adenovirus type 5 E1A products were studied with E1A deletion mutants. All appeared to bind to the amino-terminal half of E1A products in regions necessary for oncogenic transformation. These results suggest that these cellular species may be important for the biological activity of E1A products.
authors.affiliation: Department of Biology, McMaster University, Hamilton, Ontario, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Egan
authors.forename: T N
authors.initials: TN
authors.lastname: Jelsma
authors.forename: J A
authors.initials: JA
authors.lastname: Howe
authors.forename: S T
authors.initials: ST
authors.lastname: Bayley
authors.forename: B
authors.initials: B
authors.lastname: Ferguson
authors.forename: P E
authors.initials: PE
authors.lastname: Branton
mesh_terms: D017456:Adenovirus Early Proteins; D000260:Adenoviruses, Human / Q000235:genetics*; D000957:Antigens, Viral, Tumor / Q000235:genetics*; D001665:Binding Sites; D002872:Chromosome Deletion; D005796:Genes; D005814:Genes, Viral; D006801:Humans; D007624:KB Cells; D008970:Molecular Weight; D009154:Mutation; D009856:Oncogene Proteins, Viral / Q000235:genetics* / Q000378:metabolism; D011485:Protein Binding
chemical_list: D017456:Adenovirus Early Proteins; D000957:Antigens, Viral, Tumor; D009856:Oncogene Proteins, Viral