Evidence for serotonergic modulation of sucrose sham-feeding in the gastric-fistulated rat.
Both the real and sham intakes of a 5% sucrose solution were reduced by d-fenfluramine, quipazine (a 5-HT receptor agonist), and fluoxetine (a selective 5-HT reuptake inhibitor). These data demonstrate a serotonergic inhibitory component in the control of sham-feeding. In support of this, 8-OH-DPAT (a selective 5-HT1A agonist), which inhibits serotonergic activity at small doses via an autoreceptor mechanism, enhanced sucrose sham-feeding and reversed the suppressant effect of d-fenfluramine. Together, the results indicate a serotonergic influence on ingestional responses which is probably closely related to the oropharyngeal control of consumption.
Neill
J C
JC
Department of Psychology, University of Birmingham, U.K.
Cooper
S J
SJ
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D001921:Brain / Q000502:physiology*; D004435:Eating / Q000187:drug effects; D005277:Fenfluramine / Q000494:pharmacology; D005473:Fluoxetine / Q000494:pharmacology; D008297:Male; D009474:Neurons / Q000502:physiology; D011814:Quipazine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000502:physiology*; D012528:Satiety Response / Q000502:physiology*; D012701:Serotonin / Q000502:physiology*; D013270:Stomach / Q000294:innervation*; D013649:Taste / Q000502:physiology*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
D013764:Tetrahydronaphthalenes; D005473:Fluoxetine; D005277:Fenfluramine; D012701:Serotonin; D011814:Quipazine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin