Behavioural specificity of 8-OH-DPAT-induced feeding.
8-Hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) has been reported to increase food intake. This effect was confirmed in rats consuming plain or sweetened wet mash. However, the consumption of a 35% sucrose solution or of a range of other flavoured liquids was enhanced marginally if at all by a single low dose of 8-OH-DPAT, and the drug actually decreased the consumption of a high protein liquid diet. 8-OH-DPAT did, however, increase gnawing on a wooden block. These results suggest that 8-OH-DPAT-induced "hyperphagia" may to some extent be secondary to the elicitation of chewing behaviour. 8-OH-DPAT also caused certain other behavioural changes, including a suppression of grooming.
Montgomery
A M
AM
Psychology Department, City of London Polytechnic, UK.
Willner
P
P
Muscat
R
R
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D004032:Diet; D004044:Dietary Proteins / Q000494:pharmacology; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D006120:Grooming / Q000187:drug effects; D008297:Male; D008892:Milk; D009281:Naphthalenes / Q000494:pharmacology*; D051381:Rats; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D004044:Dietary Proteins; D009281:Naphthalenes; D013764:Tetrahydronaphthalenes; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin