Dehydroepiandrosterone sulfate improves memory in aging mice.
Middle-aged (18 month old) and old (24 month old) mice showed poorer retention of footshock active avoidance training (FAAT) than young mice (2 month old). Immediate post-training subcutaneous injection of dehydroepiandrosterone sulfate (DHEAS) improved retention of FAAT in middle-aged and old mice to the high levels observed in young mice. DHEAS, a major naturally occurring adrenal steroid that decreases in blood serum with age, could be rate-limiting in achievement of retention of learning.
Flood
J F
JF
Geriatric Research, Education and Clinical Center (GRECC), Veterans Administration Hospital, Sepulveda, CA 91343.
Roberts
E
E
D000375:Aging; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D019314:Dehydroepiandrosterone Sulfate; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL
D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate