Prevention of vascular prosthetic infection with an antibiotic-bonded Dacron graft.
Surfactant-mediated antibiotic bonding was used in an animal model of aortic prosthetic infection. Control grafts, control plus parenteral oxacillin, and oxacillin-bonded Dacron grafts were challenged by local inoculation with Staphylococcus aureus. Ninety percent of controls, 80% of parenteral antibiotic recipients, and only 30% of antibiotic-bonded Dacron grafts became infected (p less than 0.01, p less than 0.03). Antibiotic-bonded grafts were also superior in terms of suture line cultures and patency. In separate experiments in a subcutaneous pouch model, antibiotic bonding significantly improved the median infective dose of Dacron over that of controls and Dacron soaked in cephalosporin. These studies demonstrate that antibiotic-bonded Dacron implants are highly resistant to infection. A multicenter clinical trial is planned.
Shue
W B
WB
Department of Surgery, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903-0019.
Worosilo
S C
SC
Donetz
A P
AP
Trooskin
S Z
SZ
Harvey
R A
RA
Greco
R S
RS
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001012:Aorta, Abdominal / Q000601:surgery; D001807:Blood Vessel Prosthesis; D002440:Cefoxitin / Q000008:administration & dosage; D002511:Cephalosporins / Q000008:administration & dosage; D015169:Colony Count, Microbial; D004285:Dogs; D004343:Drug Implants; D004866:Equipment Contamination; D010068:Oxacillin / Q000008:administration & dosage; D011093:Polyethylene Terephthalates; D013211:Staphylococcus aureus / Q000187:drug effects*; D013530:Surgical Wound Infection / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004343:Drug Implants; D011093:Polyethylene Terephthalates; D002440:Cefoxitin; D010068:Oxacillin