[Effect of chalones on changes in the rat larynx induced by DMBA].
The experiments used 144 non-inbred albino male rats aged 2-3 months. They were divided in 6 study groups and one control group. The animals of groups 1-3 received 0.01 ml infusions of 6.5% solution of DMBA into the larynx twice a week for 6 months. In groups 4-5, animals were treated with acetone and dimethylsulfoxide, respectively. Epidermal chalones were instilled in group 2 1 hr after DMBA infusion, and hepatic ones--in group 3. After 7 and 10 months, the animals were sacrificed with large doses of ether, 6 sections were taken from each larynx and stained with hematoxylin--eosin. The statistically treated results showed chalone treatment to inhibit the development of precancerous lesions in larynx induced by DMBA. The greatest inhibitory effect was registered in epidermal chalone treatment.
Diagilev
V V
VV
Zabezhinskiĭ
M A
MA
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D006131:Growth Inhibitors / Q000627:therapeutic use*; D007822:Laryngeal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051381:Rats
D006131:Growth Inhibitors; D015127:9,10-Dimethyl-1,2-benzanthracene
Vliianie keĭlonov na izmeneniia v gortani krys, vyzvannye DMBA.