Enhancement of the transforming capacity of BK virus by partial deletion of the 68-base-pair tandem repeats.
We constructed a set of deleted BK viral DNAs that lack part of the triplicated 68-base-pair (bp) sequences (the central unit has an 18-bp deletion) and assayed them for capacity to transform hamster kidney cells. Deletion of one of the two 68-bp units remarkably enhanced transforming capacity.
Hara
K
K
Oya
Y
Y
Yogo
Y
Y
D001739:BK Virus / Q000235:genetics*; D002472:Cell Transformation, Viral; D002872:Chromosome Deletion; D004279:DNA, Viral; D011120:Polyomavirus / Q000235:genetics*
D004279:DNA, Viral