title: Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma.
abstract: Epidermal growth factor (EGF) receptor is expressed selectively by human melanoma cells which show the presence of an extra copy of chromosome 7. None of the cells of benign pigmented lesions (nevi) or radial growth phase (nonmetastatic) primary melanoma expressed EGF receptor and none of these cells showed an extra copy of chromosome 7. The results indicate that a single extra dose of a gene (for EGF receptor) may provide a selective advantage to cells in the late stages of tumorigenesis.
authors.forename: H
authors.initials: H
authors.lastname: Koprowski
authors.forename: M
authors.initials: M
authors.lastname: Herlyn
authors.forename: G
authors.initials: G
authors.lastname: Balaban
authors.forename: A
authors.initials: A
authors.lastname: Parmiter
authors.forename: A
authors.initials: A
authors.lastname: Ross
authors.forename: P
authors.initials: P
authors.lastname: Nowell
mesh_terms: D000911:Antibodies, Monoclonal; D002460:Cell Line; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D004815:Epidermal Growth Factor / Q000235:genetics* / Q000378:metabolism; D066246:ErbB Receptors; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000378:metabolism; D009362:Neoplasm Metastasis; D009508:Nevus, Pigmented / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D011956:Receptors, Cell Surface; D004815:Epidermal Growth Factor; D066246:ErbB Receptors