[Effect of thymalin on the development of experimental hyperlipidemia and atherosclerosis].
Thymalin, which is a polypeptide preparation from thymus, exhibited hypolipidemic and antiatherosclerotic actions in rabbits maintained on a cholesterol-containing diet during three months. At the same time, thymalin caused favourable effect on the functional activity of lymphocytes impaired in hyperlipidemic animals, i.e. it normalized the T-suppressor activity and sensitivity to atherogenic lipoproteins.
Ryzhenkov
V E
VE
Ogurtsov
R P
RP
Trubacheva
V V
VV
Popov
V G
VG
Puzyreva
V P
VP
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D001777:Blood Coagulation / Q000187:drug effects; D002464:Cell Migration Inhibition; D002784:Cholesterol / Q000097:blood; D004036:Diet, Atherogenic; D006949:Hyperlipidemias / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D007962:Leukocytes / Q000276:immunology; D008055:Lipids / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D011817:Rabbits; D051381:Rats; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013951:Thymus Hormones / Q000276:immunology / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D008055:Lipids; D008079:Lipoproteins, VLDL; D013951:Thymus Hormones; C032805:thymalin; D002784:Cholesterol
Vliianie timalina na razvitie éksperimental'noĭ giperlipidemii i ateroskleroza.