[Oncoproteins--the products of oncogenes. Tyrosine protein kinases].
The review summarizes the data mostly published in 1982 and 1983 concerning isolation, identification, cellular localization, deciphering of primary structure, and properties of the proteins coded by the retroviral oncogenes. A tentative classification of oncoproteins is suggested. The main part of the review is devoted to oncoproteins with tyrosine specific protein kinase activity. A hypothesis is proposed concerning the possible mode of action of these proteins on transforming cells. It is stressed in conclusion that the remarkable progress of our knowledge in this field has been mostly achieved due to recombinant DNA technique successfully and widely applied for studying oncogene structure and function.
Kiselev
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D000595:Amino Acid Sequence; D000818:Animals; D001358:Avian Sarcoma Viruses / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D002472:Cell Transformation, Viral; D006801:Humans; D008954:Models, Biological; D008970:Molecular Weight; D009154:Mutation; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D009857:Oncogenes; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases; D012091:Repetitive Sequences, Nucleic Acid; D012190:Retroviridae / Q000235:genetics / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism
D009363:Neoplasm Proteins; D014764:Viral Proteins; D011494:Protein Kinases; D011505:Protein-Tyrosine Kinases
Onkobelki--produkty onkogenov. Tirozinovye proteinkinazy.