Development of three human small cell lung cancer models in nude mice.
The transplantation of seven human small cell lung cancers (SCLC) into athymic nude mice resulted in the development of three tumor lines that are suitable for study of biology and for tests of new drugs and combinations. They were characterized and the response to known drugs was determined. An identical tumor response was observed in the nude mouse system and in the patient in all four comparisons available.
Fiebig
H H
HH
Neumann
H A
HA
Henss
H
H
Koch
H
H
Kaiser
D
D
Arnold
H
H
D000818:Animals; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous