Prevention of horizontal transmission of hepatitis B: efficacy of hepatitis B immunoglobulin and vaccine in an institution for the handicapped.
In a Japanese institution for the handicapped with confirmed continuous outbreaks of hepatitis B virus (HBV) infection by horizontal nosocomial transmission, 29 susceptible subjects (8 institutionalized children and 21 medical staff) were injected intramuscularly with anti-human HBs immunoglobulin (HB Ig) and subcutaneously with HB vaccine. All cases acquired HBs antibody after injection of HB Ig and seropositivity for HB after the third inoculation of HB vaccine was 78.6%. No new case of HB occurred among the study population throughout the period investigated. This suggested the effectiveness of HB Ig and HB vaccine in the prevention of horizontal nosocomial transmission of HBV.
Ueda
K
K
Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Tokugawa
K
K
Hashiguchi
Y
Y
Matsumoto
S
S
Uchimura
H
H
Shigaki
T
T
Ishihara
Y
Y
Mizuno
K
K
Tashiro
A
A
Nonaka
S
S
D000293:Adolescent; D000328:Adult; D002648:Child; D003428:Cross Infection / Q000517:prevention & control / Q000635:transmission; D006233:Persons with Disabilities; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control / Q000635:transmission*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology*; D008875:Middle Aged; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage* / Q000276:immunology
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D007074:Immunoglobulin G; D007136:Immunoglobulins; D014761:Viral Hepatitis Vaccines