title: [Hemoperfusion on charcoal and hemodialysis in acute poisoning caused by methotrexate].
abstract: Acute methotrexate intoxication occurred in 4 patients despite adequate alkaline hyperhydration and classical folinic acid rescue. Three of these patients had no previous risk factor. Charcoal haemoperfusion with haemodialysis was promptly instituted and the methotrexate blood levels rapidly decreased, avoiding further renal damage and multisystemic involvement. Chemotherapy could subsequently be performed in 3 of the 4 patients without delay and toxicity. Charcoal haemofiltration appears to be an excellent treatment of methotrexate intoxication.
authors.affiliation: Service d'Oncologie pédiatrique, Centre Léon Bérard, Lyon.
authors.forename: D
authors.initials: D
authors.lastname: Frappaz
authors.forename: E
authors.initials: E
authors.lastname: Bouffet
authors.forename: P
authors.initials: P
authors.lastname: Cochat
authors.forename: M
authors.initials: M
authors.lastname: Laville
authors.forename: J
authors.initials: J
authors.lastname: Finaz de Vilaine
authors.forename: T
authors.initials: T
authors.lastname: Philip
authors.forename: P
authors.initials: P
authors.lastname: Biron
authors.forename: M C
authors.initials: MC
authors.lastname: Zanettini
authors.forename: J F
authors.initials: JF
authors.lastname: Latour
authors.forename: A
authors.initials: A
authors.lastname: Gueho
mesh_terms: D000368:Aged; D002606:Charcoal; D002648:Child; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D007677:Kidney Function Tests; D002955:Leucovorin / Q000008:administration & dosage; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000097:blood / Q000506:poisoning* / Q000627:therapeutic use; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*
chemical_list: D002606:Charcoal; D002955:Leucovorin; D008727:Methotrexate
vernacular_title: Hémoperfusion sur charbon activé et hémodialyse dans l'intoxication aiguë au méthotrexate.