Dichloromethylene biphosphonate retards femoral expansion in normal and castrated adult male rats.
This study reports the effects of dichloromethylene biphosphonate (Cl2MBP), an inhibitor of bone remodeling, on femoral expansion in four groups of adult male rats; (1) sham-operated controls; (2) sham operated + injections of Cl2MBP; (3) castrated (osteoporotic), and (4) castrated + injections of Cl2MBP. After controlling for body weight, analyses of covariance revealed significant differences in total femoral width between animals that had received Cl2MBP and those that had not. The results indicated that Cl2MBP treatment retarded femoral expansion in both castrated and normal adult male rats.
Wink
C S
CS
Department of Anatomy, Louisiana State University Medical Center, New Orleans.
Hill
E M
EM
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects*; D004002:Clodronic Acid / Q000494:pharmacology*; D004164:Diphosphonates / Q000494:pharmacology*; D005269:Femur / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009919:Orchiectomy; D051381:Rats; D011919:Rats, Inbred Strains
D004164:Diphosphonates; D004002:Clodronic Acid