title: Peripheral polyneuropathy and monoclonal gammopathy of undetermined significance.
abstract: The prevalence of peripheral polyneuropathy in patients with monoclonal gammopathy is known to be higher than in the general population. A prevalence as high as that in the series of Osby et al, who found clinical and/or electrophysiological evidence compatible with peripheral polyneuropathy in 15 of 21 patients has not been reported before. These results could not be confirmed in a study in which 19 patients with benign monoclonal gammopathy were investigated. In contrast there were only two patients with questionable evidence of peripheral neuropathy: one had lower limb symptoms and signs only, the other had evidence of a subclinical polyneuropathy with some abnormalities of nerve conduction.
authors.forename: M J
authors.initials: MJ
authors.lastname: Krol-v Straaten
authors.forename: R G
authors.initials: RG
authors.lastname: Ackerstaff
authors.forename: C E
authors.initials: CE
authors.lastname: De Maat
mesh_terms: D000328:Adult; D000368:Aged; D002349:Carpal Tunnel Syndrome / Q000175:diagnosis; D004576:Electromyography; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000175:diagnosis* / Q000503:physiopathology; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D008297:Male; D008475:Median Nerve / Q000503:physiopathology; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D011115:Polyneuropathies / Q000175:diagnosis* / Q000503:physiopathology; D011930:Reaction Time / Q000502:physiology; D012677:Sensation / Q000502:physiology; D009435:Synaptic Transmission; D013979:Tibial Nerve / Q000503:physiopathology
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M