Elevated spontaneous mutation rate in SV40-transformed Werner syndrome fibroblast cell lines.
Spontaneous mutation rates of the cells from patients with Werner syndrome were examined, and we found that the spontaneous mutation rates at the hypoxanthine-guanine phosphoribosyltransferase locus in SV40-transformed Werner syndrome cell lines were markedly elevated, compared to those in SV40-transformed normal control cell lines. Our results suggest that Werner syndrome is a mutation mutant.
Fukuchi
K
K
Tanaka
K
K
Nakura
J
J
Kumahara
Y
Y
Uchida
T
T
Okada
Y
Y
D000328:Adult; D002460:Cell Line; D002472:Cell Transformation, Viral; D005260:Female; D005347:Fibroblasts / Q000201:enzymology; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009154:Mutation; D013539:Simian virus 40; D014898:Werner Syndrome / Q000235:genetics*
D007041:Hypoxanthine Phosphoribosyltransferase