title: Lack of inhibition of glycolytic enzymes by the neurotoxic organophosphorus compounds mipafox and methamidofos.
abstract: Preincubation with Mipafox and Methamidofos as well as Paraoxon (used as control) did not cause inhibition of hexokinase, phosphofructokinase, glyceraldehyde-3-phosphate dehydrogenase and lactate dehydrogenase. This is in contrast with the inhibition of glycolysis by other neurotoxic compounds (hexacarbons, acrylamide, carbon disulfide).
authors.affiliation: Department of Legal Medicine and Toxicology Service, Faculty of Medicine, University of Granada, Spain.
authors.forename: A F
authors.initials: AF
authors.lastname: Hernández
authors.forename: A
authors.initials: A
authors.lastname: Pla
authors.forename: E
authors.initials: E
authors.lastname: Villanueva
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors; D006019:Glycolysis / Q000187:drug effects*; D006593:Hexokinase / Q000037:antagonists & inhibitors; D007306:Insecticides / Q000633:toxicity*; D007531:Isoflurophate / Q000031:analogs & derivatives* / Q000633:toxicity; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors; D009943:Organophosphorus Compounds / Q000633:toxicity*; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D010732:Phosphofructokinase-1 / Q000037:antagonists & inhibitors
chemical_list: D004791:Enzyme Inhibitors; D007306:Insecticides; D009943:Organophosphorus Compounds; D009946:Organothiophosphorus Compounds; D007531:Isoflurophate; C005238:mipafox; C014655:methamidophos; D007770:L-Lactate Dehydrogenase; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D006593:Hexokinase; D010732:Phosphofructokinase-1