title: [Specific receptors for triiodothyronine in nuclei isolated from normal human polynuclear neutrophils].
abstract: In normal subjects, nuclei isolated and purified from circulating granulocytes bound 125I-T3. Binding was reversible and inhibited by unlabelled hormone. Scatchard plots showed a single class of high affinity sites (Kd: approximately 1,5 nM) with a high maximal binding capacity (MBC: approximately 400 fmol of T3 bound/100 micrograms of DNA). Structural analogs partially competed with 125I-T3 binding. These data suggest that human normal polymorphonuclear neutrophils possess specific nuclear receptors for triiodothyronine.
authors.forename: A
authors.initials: A
authors.lastname: Brisson-Lougarre
authors.forename: C J
authors.initials: CJ
authors.lastname: Blum
mesh_terms: D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D007457:Iodine Radioisotopes; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011988:Receptors, Thyroid Hormone
chemical_list: D007457:Iodine Radioisotopes; D011956:Receptors, Cell Surface; D011988:Receptors, Thyroid Hormone
vernacular_title: Récepteurs spécifiques à la triiodothyronine dans les noyaux isolés de polynucléaires humains normaux.