Antidotes for gold (sodium bis[thiosulfato]gold[I]) intoxication in mice.
Eight compounds were examined to determine their relative efficacy as antidotes in acute gold intoxication in mice after the intraperitoneal injection of 200 mg/kg of Na3 [Au(S2O3)2] X 2H2O. Of the compounds examined, 2,3 dimercaptosuccinic acid was the most effective antidote. It was noted that with D-penicillamine those animals which did not survive died sooner (in a matter of hours) than the corresponding control animals which had received no antidote (about 3 days). In subsequent experiments in which Na3 [Au(S2O3)2] X 2H2O was administered at the lower level of 140 mg/kg, 2,3 dimercaptosuccinic acid showed itself to be capable of reducing kidney gold levels by a factor of about 5 and liver gold levels by a factor of approximately 2.
Basinger
M A
MA
Gibbs
S J
SJ
Forti
R L
RL
Mitchell
W M
WM
Jones
M M
MM
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D005069:Evaluation Studies as Topic; D006046:Gold / Q000378:metabolism / Q000506:poisoning* / Q000633:toxicity*; D012971:Gold Sodium Thiosulfate / Q000378:metabolism / Q000506:poisoning* / Q000633:toxicity; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D007928:Lethal Dose 50; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010396:Penicillamine / Q000627:therapeutic use; D004113:Succimer / Q000627:therapeutic use; D013997:Time Factors; D014494:Unithiol / Q000627:therapeutic use
D000931:Antidotes; D014494:Unithiol; D006046:Gold; D012971:Gold Sodium Thiosulfate; D004113:Succimer; D010396:Penicillamine