Formulation and stability of iopentol.
The autoclaving studies which were performed to develop a formulation of iopentol are presented. The same formulation as used for iohexol was found to be suitable for iopentol. It was shown that it is essential to use a buffer such as trometamol to lower the pH during autoclaving in order to achieve a low level of deiodination after autoclaving. Results from the on-going stability studies indicate a good stability of iopentol finished product.
Skinnemoen
K
K
Analytical Chemistry Department, Nycomed AS, Oslo, Norway.
Fagervoll
R
R
Aanstad
L
L
Jacobsen
T
T
D003287:Contrast Media / Q000737:chemistry*; D004355:Drug Stability; D006358:Hot Temperature; D014283:Triiodobenzoic Acids / Q000737:chemistry*
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C053571:iopentol