Impaired regulation of beta-adrenoceptors in patients on maintenance haemodialysis.
In patients on maintenance haemodialysis the number of lymphocyte beta 2-adrenoceptors (determined by (+/-)-125 iodocyanopindolol binding) was not different from that in healthy controls; lymphocyte cyclic AMP responses to (-)-isoprenaline (10(-8)-10(-4) M) or NaF (10 and 50 mM), however, were significantly reduced. Dynamic exercise on a bicycle (80% of maximum heart rate) for 15 minutes caused in 10 healthy volunteers a fourfold increase in plasma catecholamines; concomitantly lymphocyte beta 2-adrenoceptor number increased by about 55 per cent. In contrast, in patients on maintenance haemodialysis exercise induced only a twofold increase in plasma catecholamines and did not affect beta 2-adrenoceptor number. It is concluded that in chronic uraemia regulation and responsiveness of beta-adrenoceptors is impaired.
Daul
A E
AE
Khalifa
A M
AM
Graven
N
N
Brodde
O E
OE
D000328:Adult; D000368:Aged; D002395:Catecholamines / Q000097:blood; D000242:Cyclic AMP / Q000097:blood; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D006435:Renal Dialysis / Q000009:adverse effects*
D002395:Catecholamines; D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP; D007545:Isoproterenol