Production of an auto-stimulatory growth factor by human hepatoma cells abrogates requirement for a brain-derived factor.
Human hepatoma cells grow at high cell density in the absence of exogenous growth factors. At low cell density, two different hepatoma cell lines required a novel growth factor from brain tissue. A factor with similar physico-chemical properties in the concentrated medium from high density cultures completely substituted for the brain extract. The autogenous secretion of a novel liver cell growth factor that is concentrated in brain tissue may underlie in part the unregulated growth of hepatomas.
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D019208:Brain-Derived Neurotrophic Factor; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003470:Culture Media; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism*; D008934:Mitogens / Q000494:pharmacology; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000502:physiology; D010452:Peptide Biosynthesis; D010455:Peptides / Q000502:physiology; D015291:Transforming Growth Factors
D019208:Brain-Derived Neurotrophic Factor; D003470:Culture Media; D006133:Growth Substances; D008934:Mitogens; D009363:Neoplasm Proteins; D010455:Peptides; C019277:brain-derived growth factor; D015291:Transforming Growth Factors