title: Elevated arterial cyclic AMP levels during the development of spontaneous hypertension in rats.
abstract: Vascular cyclic AMP alterations were studied during the initiation of vascular hypertrophy and hyperplasia in spontaneously hypertensive rats (SHR). The onset of hypertension at 6 weeks of age coexisted with a three-fold elevation in the aortic content and concentration of cyclic AMP, whereas aortic DNA and protein contents were identical to those of WKY controls. A similar cyclic AMP elevation was present in 12-week-old SHR when vascular hypertrophy and hyperplasia were already established. These experiments suggest the participation of cyclic AMP in the process of hypertensive vascular growth.
authors.forename: R E
authors.initials: RE
authors.lastname: Chatelain
authors.forename: B N
authors.initials: BN
authors.lastname: Dardik
authors.forename: R D
authors.initials: RD
authors.lastname: Robson
mesh_terms: D000375:Aging; D000818:Animals; D001158:Arteries / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D004247:DNA; D000242:Cyclic AMP