title: Visceral factors in the control of food intake.
abstract: Some years ago, we reported that the increased blood intake of hypoglycemic rats was inhibited by the intravenous infusion of fructose, a sugar that cannot cross the blood-brain barrier and nourish cerebral chemoreceptors. More recent experiments therefore have focused on visceral factors in the control of food intake. Three observations have been emphasized in this review. First, we found that gastric emptying was increased during insulin-induced hypoglycemia, and that this effect also was eliminated by administration of fructose. Hepatic vagotomy abolished both this effect of fructose on gastric emptying and its effect on food intake. Second, we found that in rats with severe diabetes, the rate of gastric emptying did decrease in proportion to increasing concentration of an administered glucose load, as it does in intact rats, but calories emptied more rapidly than normal regardless of the concentration of the load. Third, we found that rats with varying degrees of streptozotocin-induced damage to the pancreas ate more food than intact rats did after an overnight fast, and that individual intakes were proportional to the induced glucose intolerance. The increased eating took the form of shorter intermeal intervals, as if the initial postfast meal did not remain satiating for a normal amount of time. These and other findings suggest that food intake is controlled in part by satiety signals apparently related to the delivery of utilizable calories plus insulin to the liver. These signals also seem to affect gastric emptying and thereby might influence other satiety signals related to gastric distention.
authors.forename: E M
authors.initials: EM
authors.lastname: Stricker
authors.forename: M J
authors.initials: MJ
authors.lastname: McCann
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D003847:Deoxyglucose / Q000378:metabolism; D002149:Energy Intake / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D005746:Gastric Emptying / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D007003:Hypoglycemia / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology; D012527:Satiation / Q000502:physiology*; D012528:Satiety Response / Q000187:drug effects / Q000502:physiology*
chemical_list: D007328:Insulin; D011956:Receptors, Cell Surface; C027786:glucose receptor; D003847:Deoxyglucose; D005947:Glucose