Neurotoxicity of Adriamycin and misonidazole in the mouse.
The neurotoxicity of the anticancer drug adriamycin was investigated in the peripheral nerve of the mouse. Injection of adriamycin into the sciatic nerve resulted in biochemical and morphologic signs of severe axonal degeneration. The biochemical evidence was based on marked increases in lysosomal enzyme activity. Acid protease and N-acetylglucosaminidase remained elevated for more than 70 days after injecting the drug. In contrast, local injection of the radiation-sensitizing drug misonidazole into the peripheral nerve failed to increase lysosomal enzyme activity.
Boegman
R J
RJ
Scarth
B
B
Dragovic
L
L
Robertson
D M
DM
D000818:Animals; D004317:Doxorubicin / Q000009:adverse effects*; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008920:Misonidazole / Q000009:adverse effects*; D009115:Muridae; D009593:Nitroimidazoles / Q000009:adverse effects*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D012584:Sciatic Nerve / Q000201:enzymology
D009593:Nitroimidazoles; D004317:Doxorubicin; D008920:Misonidazole