The effect of campylobacter lipopolysaccharide on fetal development in the mouse.
Purified lipopolysaccharide (LPS) obtained from isolates of Campylobacter fetus ss. fetus and Campylobacter jejuni impaired fetal development when administered to mice on day 13 of pregnancy. Strikingly more fetal resorption was produced by C. jejuni LPS than by similar amounts of C. fetus ss. fetus LPS. Three of the four Campylobacter strains examined produced LPS that had no effect on maternal health, but LPS from one C. jejuni strain killed all of the mice to which it was administered.
O'Sullivan
A M
AM
Division of Comparative Medicine, Clinical Research Centre, Harrow, Middlesex.
Doré
C J
CJ
Boyle
S
S
Coid
C R
CR
Johnson
A P
AP
D000818:Animals; D002168:Campylobacter fetus; D005314:Embryonic and Fetal Development; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D005327:Fetal Resorption / Q000209:etiology* / Q000473:pathology; D005333:Fetus / Q000473:pathology; D006801:Humans; D008070:Lipopolysaccharides / Q000633:toxicity*; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D051379:Mice; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D013047:Specific Pathogen-Free Organisms; D013154:Spleen / Q000473:pathology
D008070:Lipopolysaccharides