Tetrahydroaminoacridine potentiates neurotoxicity of quinolinic acid in rat striatum.
Intraperitoneal injection of 5 mg/kg of tetrahydro-9-amino-acridine (THA) in rats 1 h before intrastriatal injection of 50-150 nmol of quinolinic acid potentiated the local neurotoxicity as indicated by measurements of striatal levels of glutamate decarboxylase and choline acetyltransferase. A larger dose (10 mg/kg) THA had no significant effect. The results are discussed in terms of THA's binding to various elements of the NMDA/sigma receptor complex and reported data on such binding are confirmed.
Zhu
S G
SG
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
McGeer
E G
EG
Singh
E A
EA
McGeer
P L
PL
D000609:Aminoacridines / Q000494:pharmacology*; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005968:Glutamate Decarboxylase / Q000378:metabolism; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology*; D011725:Pyridines / Q000633:toxicity*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013619:Tacrine / Q000494:pharmacology*
D000609:Aminoacridines; D009498:Neurotoxins; D011725:Pyridines; D011805:Quinolinic Acids; D013619:Tacrine; D002795:Choline O-Acetyltransferase; D005968:Glutamate Decarboxylase; D017378:Quinolinic Acid