title: Alpha 1-noradrenergic receptor blockade decreases nuclear estrogen receptor binding in guinea pig hypothalamus and preoptic area.
abstract: Prazosin, a putative alpha 1-noradrenergic antagonist, reduced nuclear estrogen receptor levels in the hypothalamus and preoptic area of the estrogen-primed guinea pig. Noradrenergic transmission may alter steroid-dependent processes and neuroendocrine function through actions on steroid-concentrating cells.
authors.forename: A S
authors.initials: AS
authors.lastname: Clark
authors.forename: B
authors.initials: B
authors.lastname: Nock
authors.forename: H H
authors.initials: HH
authors.lastname: Feder
authors.forename: E J
authors.initials: EJ
authors.lastname: Roy
mesh_terms: D000818:Animals; D005260:Female; D006168:Guinea Pigs; D007033:Hypothalamus, Middle / Q000187:drug effects*; D009638:Norepinephrine / Q000502:physiology; D011224:Prazosin / Q000494:pharmacology*; D011301:Preoptic Area / Q000187:drug effects*; D011799:Quinazolines / Q000494:pharmacology*; D011960:Receptors, Estrogen / Q000187:drug effects*; D011980:Receptors, Progesterone / Q000032:analysis; D009435:Synaptic Transmission
chemical_list: D011799:Quinazolines; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D009638:Norepinephrine; D011224:Prazosin