Influence of N-3-pyridoyltryptamine (tryptamide) on fetal development in rats and mice.
N-3-pyridoyltryptamine (Tryptamide, TRP) was examined for embryotoxic and teratogenic activities in rats and mice. Female Wistar rats and Albino Swiss mice were given TRP per os on days 6-14 of gestation. The rats were killed on day 21, and mice on day 18 of pregnancy. The general health and reproduction of females were evaluated, and fetuses were examined and processed to characterize external, visceral and skeletal malformations. TRP given to mothers in doses of 10 to 500 mg/kg po did not produce statistically significant embryotoxic or teratogenic effects in rats. It was not teratogenic also in mice but in this species the dose of 500 mg/kg produced embryotoxic effects.
Dłuzniewski
A
A
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Gastoł-Lewińska
L
L
Buczyńska
B
B
Moniczewski
A
A
D000818:Animals; D020964:Embryo Loss / Q000139:chemically induced; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000633:toxicity; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects; D013723:Teratogens; D014363:Tryptamines / Q000633:toxicity*
D013723:Teratogens; D014363:Tryptamines; D009536:Niacinamide; C057564:tryptamide