Effect of iopentol on coagulation and platelet function in vitro and in vivo.
The effect on hemostatic parameters of two non-ionic contrast media, iopentol and iohexol in concentrations of 350 mg I/ml, were tested in vitro. The new medium iopentol had similar effects to those of iohexol, both with respect to the intrinsic coagulation system and platelet aggregation. As part of a human pharmacologic study the effects of iopentol on hemostatic parameters were tested in 8 volunteers in vivo. Iopentol induced a slightly decreased coagulability and aggregability in venous blood. It was concluded that the effects were of very little consequence for hemostasis as a whole.
Stormorken
H
H
Research Institute for Internal Medicine, Rikshospitalet, University Hospital, Oslo, Norway.
Testart
M C
MC
Braekke
G
G
Sveen
K
K
Jakobsen
J A
JA
Grande
T
T
Andrew
E
E
D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007472:Iohexol / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D014283:Triiodobenzoic Acids / Q000494:pharmacology*
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C053571:iopentol