title: Nonenzymatic and enzymatic hydrolysis of 5-fluoro-2'-deoxyuridine (FUdR) esters.
abstract: The chemical and enzymatic reactivity of 5-fluoro-2'-deoxyuridine prodrugs esterified at the 3' and 5' positions with several acyl groups has been investigated. The enzymatic reactivity was affected by the acyl structure, the site of esterification, and the number of esters in the prodrug molecule.
authors.affiliation: Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: S
authors.initials: S
authors.lastname: Fukushima
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: M
authors.initials: M
authors.lastname: Nakano
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004950:Esterases / Q000032:analysis; D005467:Floxuridine / Q000032:analysis*; D006801:Humans; D006868:Hydrolysis; D007700:Kinetics; D013552:Swine
chemical_list: D005467:Floxuridine; D004950:Esterases