title: Griseolic acid, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. II. The structure of griseolic acid.
abstract: Griseolic acid, a potent inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase, was isolated from the fermentation broth of Streptomyces griseoaurantiacus SANK 63479. Treatment of griseolic acid with HCl-MeOH gave adenine and pseudo-sugar. The structure of griseolic acid, adenine nucleoside type structure, was elucidated by chemical degradation and X-ray analysis, and was shown to be structure 1.
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: F
authors.initials: F
authors.lastname: Nakagawa
authors.forename: K
authors.initials: K
authors.lastname: Kawazoe
authors.forename: Y
authors.initials: Y
authors.lastname: Furukawa
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: C
authors.initials: C
authors.lastname: Tamura
authors.forename: A
authors.initials: A
authors.lastname: Naito
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000107:Acetylation; D000241:Adenosine / Q000031:analogs & derivatives*; D002845:Chromatography; D003461:Crystallography; D003978:Diazomethane; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol; D008968:Molecular Conformation
chemical_list: D003978:Diazomethane; C046499:griseolic acid; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000241:Adenosine; D000432:Methanol