title: [Role opioidergic and adrenergic mechanisms in realizing the pain-alleviating action of clofelin].
abstract: It has been demonstrated on unrestrained rats that the analgesic effect of clofelin is primarily determined by the influences on the processes of adrenergic but not opioidergic mediation. The functional heterogeneity of receptor substrates involved in the realization of the hemodynamic (alpha 2-) and emotional-behavioral (alpha 1-) components of the analgesic effect of clofelin is suggested.
authors.forename: Iu D
authors.initials: IuD
authors.lastname: Ignatov
authors.forename: A A
authors.initials: AA
authors.lastname: Zaĭtsev
mesh_terms: D000700:Analgesics; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology*; D004644:Emotions / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011957:Receptors, Opioid / Q000187:drug effects*
chemical_list: D000700:Analgesics; D011941:Receptors, Adrenergic; D011957:Receptors, Opioid; D003000:Clonidine
vernacular_title: O roli opioidergicheskikh i adrenergicheskikh mekhanizmov v realizatsii boleutoliaiushchego deĭstviia klofelina.