title: Increased myocardial alpha 1 adrenoceptor density in rats chronically treated with propranolol.
abstract: Chronic treatment with propranolol for 6 weeks resulted in a 16.6% increase, over the level in control rats, in myocardial alpha 1-adrenoceptor density as measured by [3H]prazosin binding. The apparent affinity remained unaffected. No changes were observed in beta-adrenoceptor density and apparent affinity as measured by [3H]dihydroalprenolol binding. It is concluded that myocardial alpha 1-adrenoceptors might have a compensatory role under conditions where beta-adrenergic effects are attenuated.
authors.forename: A
authors.initials: A
authors.lastname: Mügge
authors.forename: C
authors.initials: C
authors.lastname: Reupcke
authors.forename: H
authors.initials: H
authors.lastname: Scholz
mesh_terms: D000818:Animals; D004082:Dihydroalprenolol / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011224:Prazosin / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000187:drug effects
chemical_list: D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D011433:Propranolol; D011224:Prazosin