Dehydroepiandrosterone sulphate and dehydroepiandrosterone in serum: differences related to age and sex.
Serum concentrations of dehydroepiandrosterone sulphate (DHAS) were determined in 590 healthy women aged 20-87 yr. Simultaneous assays of dehydroepiandrosterone (DHA) were performed in 417 of the women. DHA and DHAS levels correlated negatively with age while the DHA/DHAS ratio proved to be unrelated to age. When values for 60 healthy men in the age range 20-84 yr were compared with those obtained in 60 randomly-selected healthy women who were exactly age-matched, the DHAS levels were found to be significantly lower and the DHA/DHAS ratios significantly higher in the women. These results might be of use in establishing normal clinical ranges for serum DHA, DHAS and the DHA/DHAS ratio in women.
Carlström
K
K
Department of Obstetrics and Gynaecology, Karolinska Institutet, Huddinge University Hospital, Sweden.
Brody
S
S
Lunell
N O
NO
Lagrelius
A
A
Möllerström
G
G
Pousette
A
A
Rannevik
G
G
Stege
R
R
von Schoultz
B
B
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood*; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D006801:Humans; D008297:Male; D008593:Menopause / Q000097:blood; D008598:Menstruation; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors
D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate