Quantification of the sulfates of 16 alpha-hydroxy androgens that are possible precursors of estriol-3-sulfate in human breast cyst fluid.
The concentration of 16 alpha-hydroxydehydroepiandrosterone-3-sulfate (16 alpha-OHDHAS) was determined in 29 samples of human breast cyst fluid (BCF) and in 15 of these, androst-5-ene-3 beta,16 alpha,17 beta-triol-3-sulfate (A-TriolS) was also assayed. The median value of both was about 100 ng/mL and the ranges were from 1.4 to about 1800 ng/mL. There was a significant association in the values for the two sulfates (p less than 0.05). These concentrations are consistent with a role for 16 alpha-hydroxy androgens as possible precursors for estriol-3-sulfate. The latter is highly elevated relative to other body fluids in BCF. The androgens also correlated directly with the concentrations of K+, an indicator of apocrine proliferation of breast cysts.
Raju
U
U
Department of Obstetrics and Gynecology, New York University Medical School, New York 10016.
Levitz
M
M
Jacobowitz
G
G
Fleisher
M
M
Bencsath
F A
FA
Field
F H
FH
Breed
C N
CN
Naganuma
H
H
Bradlow
H L
HL
D000737:Androstenols / Q000032:analysis*; D001826:Body Fluids / Q000032:analysis*; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000032:analysis; D004964:Estriol / Q000031:analogs & derivatives* / Q000096:biosynthesis; D005260:Female; D005348:Fibrocystic Breast Disease / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D011188:Potassium / Q000032:analysis; D012964:Sodium / Q000032:analysis; D013431:Sulfates / Q000032:analysis*
D000737:Androstenols; D013431:Sulfates; C058059:androst-5-ene-3,16,17-triol-3-sulfate; C024368:16-hydroxydehydroepiandrosterone sulfate; D003687:Dehydroepiandrosterone; C027974:estriol 3-sulfate; D012964:Sodium; D004964:Estriol; D011188:Potassium