title: Solubility of inorganic kidney stone components in the presence of acid-base sensitive complexing agents.
abstract: Computation methods used to calculate the solubilities of the main inorganic kidney stone components in the absence or presence of acid-base-sensitive complexants as a function of pH are described. The solubilities of whewellite, brushite, whitlockite, octocalcium phosphate, hydroxyapatite and struvite were calculated in the presence of ethylenediaminetetraacetate (EDTA), trans-cyclohexane-1,2-diaminetetraacetate (CDTA), citrate, tripolyphosphate and alpha-hydroxyisobutyrate. The results explain why kidney irrigations with citrate give extremely variable results. The calculated solubility curves show that only EDTA and CDTA solutions with a pH of 8 or higher will have good litholytic properties for all compounds concerned. The computation methods presented in this paper can be used to calculate the solubility of a large number of salts. These salts may contain non-acid-base-sensitive cations capable of forming complexes, acid-base-sensitive anions, hydroxyl ions, hydrogen ions or other acid-base-sensitive cations (e.g. NH4+), and the solubilities can be calculated in the presence or absence of acid-base-sensitive complexing agents.
authors.forename: H
authors.initials: H
authors.lastname: Verplaetse
authors.forename: R M
authors.initials: RM
authors.lastname: Verbeeck
authors.forename: H
authors.initials: H
authors.lastname: Minnaert
authors.forename: W
authors.initials: W
authors.lastname: Oosterlinck
mesh_terms: D002129:Calcium Oxalate; D002130:Calcium Phosphates; D002614:Chelating Agents / Q000494:pharmacology; D002951:Citrates / Q000494:pharmacology; D017886:Durapatite; D004492:Edetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006882:Hydroxyapatites; D006885:Hydroxybutyrates / Q000494:pharmacology; D007669:Kidney Calculi / Q000378:metabolism* / Q000628:therapy; D011122:Polyphosphates / Q000494:pharmacology; D012995:Solubility; D014527:Uric Acid
chemical_list: D002130:Calcium Phosphates; D002614:Chelating Agents; D002951:Citrates; D006882:Hydroxyapatites; D006885:Hydroxybutyrates; D011122:Polyphosphates; D002129:Calcium Oxalate; D014527:Uric Acid; C005390:CDTA; D017886:Durapatite; D004492:Edetic Acid; C005692:triphosphoric acid