Spinal GABA receptors and central cardiovascular control.
Spinal superfusion with the GABA agonist muscimol reduced arterial pressure and heart-rate in the rat. Subsequent spinal administration of the GABA antagonist bicuculline restored blood pressure and heart-rate to control levels. Bicuculline alone transiently elevated blood pressure and produced a longer lasting tachycardia. Intrathecal injection of muscimol reduced sympathetic nerve discharge along with arterial pressure and cardiac rate. These results provide evidence for spinal GABA receptors participating in central cardiovascular regulation.
Gordon
F J
FJ
D000818:Animals; D001640:Bicuculline / Q000031:analogs & derivatives / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D018756:GABA Antagonists; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*
D018756:GABA Antagonists; D011963:Receptors, GABA-A; D009118:Muscimol; C017069:bicuculline methiodide; D001640:Bicuculline