title: Persistent Epstein-Barr virus infection and a histiocytic sarcoma in a renal transplant recipient.
abstract: Lymphomas occurring in renal transplant recipients are mostly large cell non-Hodgkin's lymphomas (B-cell-derived). A sarcoma with all morphologic, immunohistochemical, and ultrastructural characteristics of a tumor of the mononuclear phagocytic system (MPS) developed in a 23-year-old woman 1 year after renal transplantation. Anti-Epstein-Barr-virus antibody titers proved to be exceptionally high, even in pretransplant sera. Tumor-derived cells proved to be positive for Epstein-Barr nuclear antigen (EBNA), and hybridization showed multiple copies of Epstein-Barr virus (EBV)-DNA, suggesting a relationship between this tumor and EBV. More widespread use of immunochemical and histochemical diagnostic techniques might detect more cases, which, until now, have probably been diagnosed as B-cell-derived immunoblastic lymphomas.
authors.forename: P
authors.initials: P
authors.lastname: Kramer
authors.forename: M E
authors.initials: ME
authors.lastname: Prins
authors.forename: J G
authors.initials: JG
authors.lastname: Kapsenberg
authors.forename: G W
authors.initials: GW
authors.lastname: Bornkamm
authors.forename: A B
authors.initials: AB
authors.lastname: Bijnen
authors.forename: P J
authors.initials: PJ
authors.lastname: Rohol
authors.forename: R O
authors.initials: RO
authors.lastname: van der Heul
authors.forename: J
authors.initials: J
authors.lastname: Jeekel
authors.forename: W
authors.initials: W
authors.lastname: Weimar
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000032:analysis; D001932:Brain Neoplasms / Q000556:secondary; D002213:Capsid / Q000276:immunology; D004279:DNA, Viral / Q000032:analysis; D019309:Epstein-Barr Virus Nuclear Antigens; D005260:Female; D006566:Herpesviridae Infections / Q000209:etiology* / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D007680:Kidney Neoplasms / Q000209:etiology* / Q000276:immunology; D016030:Kidney Transplantation; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology* / Q000276:immunology / Q000556:secondary; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000556:secondary / Q000648:ultrastructure
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D004279:DNA, Viral; D019309:Epstein-Barr Virus Nuclear Antigens