The anti-inflammatory and analgesic activity of N-3-pyridoyltryptamine (tryptamide).
In this study we compared the antiinflammatory and analgesic properties of N-3-pyridoyltryptamine (tryptamide, TRP) with those of standard non-steroid anti-inflammatory drugs (phenylbutazone, indometacin, piroxicam and ibuprofen). Antiinflammatory properties were investigated in the carrageenin-, serotonin-, kaolin-, formalin- and xylene-induced edema tests and in the cotton pellet granuloma test. The analgesic properties were studied in the writing, hot plate and electrical stimulation tests. In the majority of the applied tests TRP reveals the activity resembling this of phenylbutazone, and several times weaker than the effect of the remaining standard drugs. The ulcerogenic effect of TRP is very weak, and its effective doses are several times higher than these of the compared substances. Hence the therapeutic indices of TRP are several times higher than these of the other examined substances. The obtained results indicate that TRP is a putative anti-inflammatory and analgesic drug, much safer that other known substances with a similar pharmacological profile.
Maj
J
J
Institute of Pharmacology, Polish Academy of Sciences, kraków.
Chojnacka-Wójcik
E
E
Gancarczyk
L
L
Tatarczyńska
E
E
Wiczyńska
B
B
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002351:Carrageenan / Q000633:toxicity; D004487:Edema / Q000188:drug therapy; D005557:Formaldehyde / Q000633:toxicity; D005753:Gastric Mucosa / Q000187:drug effects; D007052:Ibuprofen / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007616:Kaolin / Q000633:toxicity; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D010894:Piroxicam / Q000494:pharmacology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000633:toxicity; D014363:Tryptamines / Q000494:pharmacology*; D014992:Xylenes / Q000633:toxicity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014363:Tryptamines; D014992:Xylenes; D010894:Piroxicam; D005557:Formaldehyde; D007616:Kaolin; D009536:Niacinamide; C057564:tryptamide; D012701:Serotonin; D002351:Carrageenan; D011451:Prostaglandin-Endoperoxide Synthases; D010653:Phenylbutazone; D007052:Ibuprofen; D007213:Indomethacin