title: Sudden hearing loss following infectious mononucleosis: possible effect of altered immunoregulation.
abstract: Sudden, permanent hearing loss developed in three young patients. In an attempt to determine a viral etiology, their humoral and cell-mediated responses to a panel of seven viruses linked to deafness and altered immunity were measured. Although a specific viral cause was not determined, a mild Epstein-Barr virus infection was documented for each patient. It had preceded their hearing loss onset by 1 to 4 months. Evidence of altered cell-mediated responses to Epstein-Barr virus antigens was found in each patient. It is proposed that, in certain susceptible individuals, a temporary cellular immunosuppression, which accompanies normal recovery from Epstein-Barr virus infection, may provide an opportunity for a viral invasion of, or a latent viral reactivation in, the inner ear. This invasion or reactivation leads to deafness.
authors.forename: L L
authors.initials: LL
authors.lastname: Williams
authors.forename: H W
authors.initials: HW
authors.lastname: Lowery
authors.forename: R
authors.initials: R
authors.lastname: Glaser
mesh_terms: D000293:Adolescent; D000917:Antibody Formation; D002648:Child; D003638:Deafness / Q000209:etiology* / Q000276:immunology; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007109:Immunity; D007111:Immunity, Cellular; D007244:Infectious Mononucleosis / Q000150:complications* / Q000276:immunology; D008297:Male