Possible animal models of follicular development relevant to reproductive toxicology.
Models of follicular development in rodents that may be applicable to reproductive toxicology are considered. The value of evaluating changes in follicular numbers during the estrous cycle is stressed. Most of the methods involve in vivo manipulations. However, the use of enzymes to dissociate intact follicles from the ovary and their subsequent in vitro development in the presence or absence of xenobiotics offers an alternative, attractive approach.
Greenwald
G S
GS
Department of Physiology, University of Kansas Medical Center, Kansas City 66103.
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D066298:In Vitro Techniques; D006080:Ovarian Follicle / Q000187:drug effects*; D010052:Ovariectomy; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects*; D013480:Superovulation / Q000187:drug effects