Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus.
A study was conducted of the genetic relation between human T-cell lymphotropic retroviruses and visna virus. The human T-cell lymphotropic viruses include those associated with T-cell malignancies (HTLV-I and HTLV-II) as well as the etiologic agent of the acquired immune deficiency syndrome (HTLV-III). Visna virus, a slowly replicating and pathogenic but nononcogenic retrovirus of sheep, is a member of the subfamily Lentivirinae. Results obtained by molecular hybridization and heteroduplex analysis indicated that a greater extent of nucleotide sequence homology exists between HTLV-III and visna virus than between HTLV-III and any of the other viruses. The homology observed under conditions of low stringency spanned the entire genome, but was strongest in the gag/pol region. The morphogenesis and fine structure of HTLV-III and visna virus also demonstrated striking similarities. The data provide strong evidence for a close taxonomic and thus evolutionary relation between HTLV-III and the Lentivirinae subfamily.
Gonda
M A
MA
Wong-Staal
F
F
Gallo
R C
RC
Clements
J E
JE
Narayan
O
O
Gilden
R V
RV
D001483:Base Sequence; D017977:Deltaretrovirus / Q000235:genetics* / Q000648:ultrastructure; D005814:Genes, Viral; D008854:Microscopy, Electron; D009692:Nucleic Acid Heteroduplexes; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral; D014790:Visna-maedi virus / Q000235:genetics* / Q000648:ultrastructure
D009692:Nucleic Acid Heteroduplexes; D012367:RNA, Viral