title: Limited impact of total parenteral nutrition on nutritional status during treatment for small cell lung cancer.
abstract: During a randomized trial of total parenteral nutrition (TPN) in patients with small cell lung cancer, we evaluated the short- and long-term effects of 4 weeks of TPN on nutritional assessment parameters. All 119 patients who were accrued to the study received the same chemotherapy and radiotherapy protocol which extended over a 1-year period: 57 patients received TPN; and 62 served as controls. At base line, patients with greater than 5% pretreatment weight loss had significantly lower levels of serum albumin, total iron-binding capacity, and creatinine/height index. TPN administration led to a significant increase in mean caloric intake and weight compared with controls (P less than 0.0001). In the short-term study, body fat, as measured by triceps skinfold thickness, was maintained, and there was a small increase in arm muscle circumference. Serum albumin and hematocrit decreased but promptly returned to pretreatment levels when TPN was stopped. There were no long-term differences in any of the nutritional assessment parameters between the two groups.
authors.forename: W K
authors.initials: WK
authors.lastname: Evans
authors.forename: R
authors.initials: R
authors.lastname: Makuch
authors.forename: G H
authors.initials: GH
authors.lastname: Clamon
authors.forename: R
authors.initials: R
authors.lastname: Feld
authors.forename: R S
authors.initials: RS
authors.lastname: Weiner
authors.forename: E
authors.initials: E
authors.lastname: Moran
authors.forename: R
authors.initials: R
authors.lastname: Blum
authors.forename: F A
authors.initials: FA
authors.lastname: Shepherd
authors.forename: K N
authors.initials: KN
authors.lastname: Jeejeebhoy
authors.forename: W D
authors.initials: WD
authors.lastname: DeWys
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D000368:Aged; D001827:Body Height; D001835:Body Weight; D018288:Carcinoma, Small Cell / Q000628:therapy*; D003404:Creatinine / Q000097:blood; D002149:Energy Intake; D005110:Extracellular Space; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism; D009747:Nutritional Physiological Phenomena; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D012709:Serum Albumin / Q000032:analysis; D013997:Time Factors
chemical_list: D012709:Serum Albumin; D003404:Creatinine; D009584:Nitrogen