The influence of mixed venous pO2 on the natriuretic activity of cat plasma.
Plasma was taken from anaesthetised cats with high or low mixed venous pO2. Different plasma fractions were then administered to anaesthetised rats to examine the effect on sodium excretion. It was found that only the low molecular weight fraction of the plasma from cast with high mixed venous pO2 showed any natriuretic activity. A lipid soluble extract from the same plasma also increased sodium excretion. It is concluded that an increase in mixed venous pO2 in anaesthetised cats leads to the release or activation of a natriuretic factor, which has a molecular weight below 700 and is lipid soluble.
Roloff
D
D
Institute of Physiology, Humboldt University, Berlin, DDR.
Flemming
B
B
Ludwig
C
C
Fritzsche
H
H
Schueler
F
F
Streichan
F
F
Wronski
T
T
D000818:Animals; D002415:Cats; D008297:Male; D008970:Molecular Weight; D009318:Natriuresis; D045283:Natriuretic Agents / Q000097:blood; D010100:Oxygen / Q000097:blood*; D051381:Rats; D012964:Sodium / Q000652:urine; D014680:Veins
D045283:Natriuretic Agents; D012964:Sodium; D010100:Oxygen