Studies of reproductive cyclicity: evaluation of computer modeling as a tool.
Assessment of toxic effects on human reproductive function using fetal health or teratogenic criteria presumes the conditions of parental fertility. Toxins that compromise fecundity through derangement of the menstrual cycle may require quite different models and criteria. Nonlinear dynamic interactions of the hormonal and morphological components of the menstrual cycle add to the difficulty of such studies. With appropriate mathematical models, computer simulation can provide a useful guide to the design and conduct of in vivo experiment.
Ferin
M
M
Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, New York 10027.
Bogumil
R J
RJ
D003198:Computer Simulation; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology*; D008954:Models, Biological