title: Thermodynamic limits to the stoichiometry of H+ pumping by mitochondrial cytochrome oxidase.
abstract: H+/O stoichiometries of 0, 2 and 4 have been proposed for cytochrome oxidase. Here we show that a stoichiometry of 4 is thermodynamically impossible for rat liver cytochrome oxidase under normal conditions.
authors.forename: M P
authors.initials: MP
authors.lastname: Murphy
authors.forename: G C
authors.initials: GC
authors.lastname: Brown
authors.forename: M D
authors.initials: MD
authors.lastname: Brand
mesh_terms: D000818:Animals; D003576:Electron Transport Complex IV / Q000378:metabolism*; D007700:Kinetics; D008433:Mathematics; D008930:Mitochondria, Liver / Q000201:enzymology*; D011522:Protons; D051381:Rats; D013816:Thermodynamics
chemical_list: D011522:Protons; D003576:Electron Transport Complex IV