title: Potency and efficacy of inactivated bluetongue virus vaccines.
abstract: Bluetongue virus (BTV) was chemically inactivated and was shown to elicit neutralizing antibodies in vaccinated rabbits and sheep. In sheep, the neutralizing antibody was shown to be protective by immunity challenge with virulent virus. These studies have shown the feasibility of safe and effective inactivated vaccines for bluetongue (BT) disease of sheep.
authors.forename: D R
authors.initials: DR
authors.lastname: Stevens
authors.forename: J
authors.initials: J
authors.lastname: Stott
authors.forename: B I
authors.initials: BI
authors.lastname: Osburn
authors.forename: R
authors.initials: R
authors.lastname: Giles
authors.forename: G P
authors.initials: GP
authors.lastname: Wiesehahn
authors.forename: T L
authors.initials: TL
authors.lastname: Barber
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001819:Bluetongue / Q000517:prevention & control*; D001820:Bluetongue virus / Q000276:immunology*; D011817:Rabbits; D012087:Reoviridae / Q000276:immunology*; D012756:Sheep / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines