Inputs from the A1 noradrenergic region to hypothalamic paraventricular neurons in the rat.
Electrical stimulation of the rat A1 noradrenergic region produced excitation (77%) of the activity of putative vasopressin (VP)-secreting neurons in the paraventricular nucleus (PVN) and produced excitation (4%), inhibition (26%) and excitation-inhibition (11%) of the activity of PVN neurons that were not antidromically identified by neurohypophysial stimulation. The excitatory response of putative VP-secreting neurons was blocked by microiontophoretically applied phentolamine, an alpha-adrenoceptor antagonist, but not by timolol, a beta-adrenoceptor antagonist. The inhibitory response of unidentified PVN neurons, on the other hand, was blocked by timolol, but not by phentolamine.
Tanaka
J
J
Kaba
H
H
Saito
H
H
Seto
K
K
D000320:Adrenergic Fibers / Q000502:physiology; D000818:Animals; D001931:Brain Mapping; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology*; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D014667:Vasopressins / Q000378:metabolism
D011942:Receptors, Adrenergic, alpha; D014667:Vasopressins; D009638:Norepinephrine