title: T-cell acute lymphoblastic leukemia with severe leukopenia: evidence for suppression of myeloid progenitor cells by leukemic blasts.
abstract: A patient with T-cell acute lymphoblastic leukemia presented with leukopenia due to neutropenia, no circulating blasts and normal hemoglobin level. Marrow leukemic T lymphoblasts inhibited in vitro normal CFU-GM colony growth and released an activity that stimulated normal BFU-E growth. This patient demonstrates that immature T cells may modify hematopoietic stem cell growth both in vitro and in vivo.
authors.affiliation: Institute of Hematology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Douer
authors.forename: I
authors.initials: I
authors.lastname: Ben-Bassat
authors.forename: P
authors.initials: P
authors.lastname: Froom
authors.forename: N
authors.initials: N
authors.lastname: Shaked
authors.forename: B
authors.initials: B
authors.lastname: Ramot
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000276:immunology* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000276:immunology* / Q000473:pathology; D003114:Colony-Forming Units Assay; D003470:Culture Media; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000276:immunology* / Q000473:pathology; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology* / Q000473:pathology; D007970:Leukopenia / Q000276:immunology* / Q000473:pathology; D008297:Male; D010641:Phenotype; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology* / Q000473:pathology
chemical_list: D003470:Culture Media