title: Histologic evaluation of the luteal phase in women following follicle aspiration for oocyte retrieval.
abstract: The luteal phase was evaluated by endometrial biopsy (EMB) 11 to 13 days after administration of human chorionic gonadotropin (hCG) or initiation of the luteinizing hormone (LH) surge (hCG/LH) in 25 stimulated patients not undergoing embryo transfer (ET). Luteal phase defect (LPD) was defined as an EMB greater than 2 days out-of-phase when compared with the onset of subsequent menses. Nineteen women (76%) had LPDs ranging from 3 to 7 days. Mean estradiol (E2) on day of hCG/LH was significantly (P less than 0.01) higher (1709 +/- 997) in patients with in-phase EMBs than mean E2 levels in two groups of patients with out-of-phase EMBs (687 +/- 251, 941 +/- 366, respectively). These findings are further evidence of the importance of optimal follicular development to subsequent endometrial maturation.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine, New York, New York.
authors.forename: M J
authors.initials: MJ
authors.lastname: Graf
authors.forename: J V
authors.initials: JV
authors.lastname: Reyniak
authors.forename: P
authors.initials: P
authors.lastname: Battle-Mutter
authors.forename: N
authors.initials: N
authors.lastname: Laufer
mesh_terms: D000328:Adult; D001706:Biopsy; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004717:Endometrium / Q000033:anatomy & histology* / Q000503:physiopathology; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D010535:Laparoscopy; D008183:Luteal Phase; D007986:Luteinizing Hormone / Q000097:blood; D009865:Oocytes; D010062:Ovulation Induction / Q000379:methods
chemical_list: D006063:Chorionic Gonadotropin; D004958:Estradiol; D007986:Luteinizing Hormone