[Comparative effectiveness of the combined use of fenazepam, haloperidol, lithium and metabolic preparations in treating the psychopathologic disorders with obsessions in slowly progressive schizophrenia].
The effectiveness of combined phenazepam, lithium, haloperidol and metabolic drugs (alpha-tocopherol, pyridoxal phosphate, nicotinamide) treatment of patients with slow progredient schizophrenia is analyzed. The psychotropic drugs were administered at doses lower below mean therapeutic ones by 1/2 to 1/3. Combined therapy proved effective even in the cases resistant to active antipsychotic treatment. No considerable untoward effects (extrapyramidal disorders) were found. The therapy had a differentiated impact on the obsessive syndrome and other borderline psychopathologic states. These advantages allow one to recommend the therapy for long-term support in schizophrenic patients with benign course of the disease.
Kadysheva
N M
NM
Mokhovikov
A N
AN
Mosketi
K V
KV
Kryzhanovskiĭ
G N
GN
D000293:Adolescent; D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use*; D002908:Chronic Disease; D003193:Compulsive Personality Disorder / Q000188:drug therapy* / Q000209:etiology; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use*; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000627:therapeutic use; D010554:Personality Disorders / Q000188:drug therapy*; D011599:Psychopathology; D011732:Pyridoxal Phosphate / Q000627:therapeutic use; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; D014810:Vitamin E; D009536:Niacinamide; C017928:phenazepam; D011732:Pyridoxal Phosphate; D008094:Lithium; D024502:alpha-Tocopherol; D006220:Haloperidol; D024505:Tocopherols
Sravnitel'naia éffektivnost' kompleksnogo primeneniia fenazepama, galoperidola, litiia i metabolicheskikh preparatov v lechenii psikhopatologicheskikh rasstroĭstv s naviazchivostiami pri maloprogredientnoĭ shizofrenii.