title: Emerging strategies in ulcer therapy: pumps and receptors.
abstract: The treatment of gastric and duodenal ulcers has recently been revolutionised. The reason for this is the increased knowledge of the physiology and biochemistry of the mucosae at the cellular and subcellular levels. In this article, we try to explain how the gastric parietal cell works, and how, based on that knowledge, we might be able to devise increasingly sophisticated tools for inhibition of acid secretion.
authors.forename: T
authors.initials: T
authors.lastname: Berglindh
authors.forename: G
authors.initials: G
authors.lastname: Sachs
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D009853:Omeprazole; D010295:Parietal Cells, Gastric / Q000187:drug effects*; D011522:Protons; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011949:Receptors, Cholecystokinin; D011968:Receptors, Histamine / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D011976:Receptors, Muscarinic / Q000187:drug effects*; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology; D013276:Stomach Ulcer / Q000188:drug therapy
chemical_list: D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D011522:Protons; D011956:Receptors, Cell Surface; D011949:Receptors, Cholecystokinin; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D011976:Receptors, Muscarinic; D000254:Sodium-Potassium-Exchanging ATPase; D009853:Omeprazole