title: Technetium-99m MAG3, a comparison with iodine-123 and iodine-131 orthoiodohippurate, in patients with renal disorders.
abstract: A Phase I study in 12 patients with renal disorders compared the simultaneous clearances of 99mTc-labeled mercaptoacetyltriglycine (MAG3) and 131I-labeled orthoiodohippurate (OIH). The ratio of MAG3 to OIH clearance was 0.61 +/- 0.08 as a result of its smaller volume of distribution, ratio 0.65 +/- 0.09, for the clearance half-lives were similar, ratio 1.09 +/- 0.12. A Phase II study performed serially in 20 patients with equal doses of [99mTc]MAG3 and [123I]OIH gave images of equal quality. The relative renal functions were highly correlated (r = 0.97, p less than 0.001) and transit time analyses gave good correlations: parenchymal transit time index r = 0.81, p less than 0.05. We conclude that [99mTc]MAG3 has some advantages over [99mTc]DTPA and is a suitable replacement for [123I]hippuran in routine renal imaging, relative function, and transit time studies, but not for the accurate estimation of the renal plasma flow.
authors.affiliation: Department of Nuclear Medicine, St. Bartholomew's Hospital, London, United Kingdom.
authors.forename: R A
authors.initials: RA
authors.lastname: Jafri
authors.forename: K E
authors.initials: KE
authors.lastname: Britton
authors.forename: C C
authors.initials: CC
authors.lastname: Nimmon
authors.forename: K
authors.initials: K
authors.lastname: Solanki
authors.forename: A
authors.initials: A
authors.lastname: Al-Nahhas
authors.forename: J
authors.initials: J
authors.lastname: Bomanji
authors.forename: J
authors.initials: J
authors.lastname: Fettich
authors.forename: L A
authors.initials: LA
authors.lastname: Hawkins
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007465:Iodohippuric Acid / Q000493:pharmacokinetics; D007674:Kidney Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000493:pharmacokinetics; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D011866:Radioisotope Renography; D013667:Technetium / Q000493:pharmacokinetics; D017263:Technetium Tc 99m Mertiatide
chemical_list: D009842:Oligopeptides; D009942:Organometallic Compounds; D007465:Iodohippuric Acid; D017263:Technetium Tc 99m Mertiatide; D013667:Technetium