title: Biochemical changes in rhesus monkey during the first days after streptozotocin administration are indicative of selective beta cell destruction.
abstract: Hormonal and glycemic changes in 22 rhesus monkeys were characterized during the first days after treatment with streptozotocin (STZ) (45 to 55 mg/kg, administered intravenously [IV]). Almost half (10/22) of the monkeys developed insulin-dependent diabetes mellitus (STZ-IDDM) within five days following injection. Four of the remaining monkeys did not become insulin dependent for at least 6 months after STZ treatment, during which time they were considered non-insulin-dependent, and eight monkeys never required exogenous insulin. In the STZ-IDDM group, plasma immunoreactive c-peptide (IRC-P) levels fell by three hours after STZ from a mean +/- SEM of 252 +/- 82 to 101 +/- 45 pg/mL, as glucose and immunoreactive glucagon (IRG) levels increased from 65 +/- 3 and 120 +/- 37, respectively, to 336 +/- 43 mg/dL and 234 +/- 52 pg/mL, respectively. Between six and 30 hours after treatment, IRC-P increased to a peak of 1,561 +/- 360 pg/mL before falling permanently to less than 60 pg/mL by 66 hours. During this period, glucose and IRG responded in a reciprocal fashion by falling and then increasing to levels above 300 mg/dL and 300 pg/mL, respectively, by 66 hours. In the non-insulin-dependent diabetes mellitus (STZ-NIDDM) group, no clear reciprocal relationship between IRC-P and glucose and IRG was obtained. In nine additional monkeys subjected to total pancreatectomy (Px), IRC-P and IRG levels fell immediately and permanently by greater than 90% and 75%, respectively. Levels of immunoreactive somatostatin increased steadily over the initial 96 hours following STZ, but did so both STZ-IDDM and Px monkey groups.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Surgery, University of Illinois College of Medicine, Chicago.
authors.forename: G
authors.initials: G
authors.lastname: Takimoto
authors.forename: C
authors.initials: C
authors.lastname: Jones
authors.forename: W
authors.initials: W
authors.lastname: Lands
authors.forename: A
authors.initials: A
authors.lastname: Bauman
authors.forename: J
authors.initials: J
authors.lastname: Jeffrey
authors.forename: O
authors.initials: O
authors.lastname: Jonasson
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005609:Free Radicals; D005934:Glucagon / Q000097:blood; D006442:Glycated Hemoglobin / Q000032:analysis; D007515:Islets of Langerhans / Q000187:drug effects*; D008253:Macaca mulatta; D013311:Streptozocin / Q000633:toxicity*
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D005609:Free Radicals; D005934:Glucagon; D006442:Glycated Hemoglobin; D013311:Streptozocin