Automatic assessment of the interaction between respiration and heart rate variability signal.
The present paper introduces an original method of processing heart rate variability (HRV) and respiration signals as detected respectively through chest electrodes and thoracic belt in dogs under different experimental conditions. Signals are processed as time series synchronous with the occurrence of QRS complexes on ECG signal and auto and cross spectra are accordingly calculated. Two particular bands appear mainly of interest on the spectrum of HRV signal: one in correspondence with the respiration rate and another one at a lower frequency value. Values of power at these frequency bands together with coherence and phase between HRV signal and respiration complete the parameters which try to quantify a few aspects of the complex dynamic relationships between the original signals. In particular, controlled respiration in dogs was studied through the connection with an automatic ventilator, as well as the effects of drugs which interact with the neural regulatory systems (i.e. sympathetic and parasympathetic nervous system). Gain and phase relationships between heart rate variability and respiration, obtained with spectral analysis, could be used to provide a better understanding of the neural control mechanisms linking heart rate and respiration in various experimental conditions. The method described in this study is to be used both in physiological and clinical research.
Cerutti
S
S
Dipartimento di Elettronica, Politecnico di Milano, Italy.
Alberti
M
M
Baselli
G
G
Rimoldi
O
O
Malliani
A
A
Merri
M
M
Pagani
M
M
D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D004285:Dogs; D004562:Electrocardiography; D006339:Heart Rate; D012119:Respiration; D013997:Time Factors