title: Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes.
abstract: The c-mos proto-oncogene is expressed as a maternal mRNA in oocytes and early embryos of Xenopus laevis, but its translation product pp39mos is detectable only during progesterone-induced oocyte maturation. Microinjection of mos-specific antisense oligonucleotides into oocytes not only prevents expression of pp39mos, but also blocks germinal vesicle breakdown, indicating that it functions during reinitiation of meiotic division.
authors.affiliation: Bionetics Research Inc., National Cancer Institute, Frederick, Maryland 21701.
authors.forename: N
authors.initials: N
authors.lastname: Sagata
authors.forename: M
authors.initials: M
authors.lastname: Oskarsson
authors.forename: T
authors.initials: T
authors.lastname: Copeland
authors.forename: J
authors.initials: J
authors.lastname: Brumbaugh
authors.forename: G F
authors.initials: GF
authors.lastname: Vande Woude
mesh_terms: D000818:Animals; D001483:Base Sequence; D004247:DNA; D005260:Female; D008540:Meiosis; D008938:Mitosis; D008969:Molecular Sequence Data; D009857:Oncogenes; D009865:Oocytes / Q000254:growth & development*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D017231:Proto-Oncogene Proteins c-mos; D014981:Xenopus / Q000196:embryology*
chemical_list: D011518:Proto-Oncogene Proteins; D004247:DNA; D017231:Proto-Oncogene Proteins c-mos