Hematoporphyrin ethers--II. Improvements in method, synthesis of the dihexyl, dicyclohexanyl and diphenyl ethers and their preliminary biological evaluation.
1. Hematoporphyrin 2.4-dihexyl, -dicyclohexanyl and -diphenyl ethers have been synthesized. 2. Their chemical and physical properties are recorded. The possibility of isomerism is discussed. 3. Preliminary tests have indicated that they possess high photosensitizing efficiency on human cancer cells.
Rimington
C
C
Institute for Cancer Research, Department of Biophysics, Oslo, Norway.
Rønnestad
A
A
Western
A
A
Moan
J
J
D002851:Chromatography, High Pressure Liquid; D003460:Crystallization; D017323:Dihematoporphyrin Ether; D004987:Ethers / Q000138:chemical synthesis* / Q000494:pharmacology; D006414:Hematoporphyrin Photoradiation; D006415:Hematoporphyrins / Q000138:chemical synthesis* / Q000494:pharmacology; D013058:Mass Spectrometry; D013050:Spectrometry, Fluorescence
D004987:Ethers; D006415:Hematoporphyrins; C059831:hematoporphyrin dihexyl ether; C059829:hematoporphyrin dicyclohexanyl ether; C059828:hematoporphyrin diphenyl ether; D017323:Dihematoporphyrin Ether