[Selective anticonvulsive action of N-substituted imidazole-4,5-dicarboxylic acids against quinolinic acid].
Selective antagonists of quinolinic acid (2,3-pyridine dicarboxylic acid, QUIN)--an endogenous convulsant tryptophan metabolite, administered intracerebroventricular to mice, were identified during comparison with the following intracerebroventricular convulsants: l-kynurenine, aspartic, glutamic, N-methyl-DL-aspartic and kainic acids. It is suggested that the antagonism arises due to a common fragment of the structure which consists of two carboxylic groups at two nearest carbon atoms of the ring and of one nitrogen atom in the alpha-position. The selective action of the compounds found against QUIN supports the suggestion that QUIN produces seizures via N-methyl-D-aspartate binding sites.
Ryzhov
I V
IV
Lapin
I P
IP
Piotrovskiĭ
L B
LB
Aleksandrova
I Ia
IIa
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D003998:Dicarboxylic Acids / Q000627:therapeutic use*; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D011725:Pyridines / Q000037:antagonists & inhibitors*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000037:antagonists & inhibitors*; D012640:Seizures / Q000139:chemically induced* / Q000517:prevention & control
D000927:Anticonvulsants; D003998:Dicarboxylic Acids; D007093:Imidazoles; D011725:Pyridines; D011805:Quinolinic Acids; C056868:1-methylimidazole-4,5-dicarboxylic acid; C056866:1-benzylimidazole-4,5-dicarboxylic acid; C056867:1-ethylimidazole-4,5-dicarboxylic acid; D017378:Quinolinic Acid
Izbiratel'noe protivosudorozhnoe deĭstvie N-zameshchennykh imidazol-4,5-dikarbonovykh kislot protiv khinolinovoĭ kisloty.