The effects of desogestrel and ethinylestradiol combination in normal and hyperandrogenic young girls: speculations on contraception in adolescence.
Hormone profile and ovarian morphology were studied in two groups of adolescents (group 1:19 girls with slight signs of hyperandrogenism; group 2: 14 normal adolescents) in basal conditions and during a contraceptive combination of 30 micrograms ethinyl estradiol (EE) and 150 micrograms desogestrel (D). Treatment was associated with a low incidence of side effects in both groups. In group 1, acne generally improved within 12 months while hirsutism was only reduced in some subjects (58%) after 12 months of therapy (basal hair score 8.50 +/- 1.60 vs 5.81 +/- 1.53 p less than 0.001). Significant falls in plasma levels of LH, total and free testosterone and an increase in sex-hormone-binding globulin levels were observed during treatment especially in group 1. High percentage of multifollicular ovaries (75%) characterized hyperandrogenic subjects. Ovarian volume and number of follicles, higher in group 1 than 2 in basal conditions, showed a significant reduction in both groups and normal ovarian morphology was restored in hyperandrogenic subjects. Considering the high incidence of hyperandrogenemia in adolescence and its implications, our data suggest that the EE.D combination suits adolescent biological condition and is one of the suitable contraceptive methods in adolescents which also has therapeutic effects.
Venturoli
S
S
Institute of Reproductive Physiology and Pathology, University of Bologna, Italy.
Porcu
E
E
Gammi
L
L
Fabbri
R
R
Paradisi
R
R
Flamigni
C
C
Patrono
D
D
Capelli
M
M
Paoletti
C
C
D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D000728:Androgens / Q000097:blood*; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage*; D017135:Desogestrel; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006628:Hirsutism / Q000188:drug therapy; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects; D009652:Norpregnenes / Q000008:administration & dosage*; D010048:Ovarian Cysts / Q000188:drug therapy
D000728:Androgens; D003277:Contraceptives, Oral, Combined; D009652:Norpregnenes; D004997:Ethinyl Estradiol; D017135:Desogestrel