title: The non immunogenicity of CALLA in leukemic children.
abstract: The sera from 55 children with acute lymphoblastic leukemia (ALL) treated with active immunotherapy were examined for the presence of antibodies against common ALL antigen (CALLA). A solid phase indirect radioimmunometric assay (IRA) was developed which enabled the detection of anti-CALLA antibody in patients' sera, utilizing the ability of affinity-purified CALLA to bind Ricinus communis agglutinin and anti-CALLA antibody simultaneously. Using IRA, anti-CALLA antibody activity could not be detected in a majority of patients. We concluded that the patients did not raise comparable antibodies against CALLA, indicating this antigen is not immunogenic for ALL patients.
authors.affiliation: Department of Pediatrics, Mie University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Komada
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: E
authors.initials: E
authors.lastname: Azuma
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Kamiya
authors.forename: M
authors.initials: M
authors.lastname: Sakurai
mesh_terms: D000912:Antibodies, Neoplasm / Q000276:immunology*; D000943:Antigens, Differentiation / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D002648:Child; D006801:Humans; D007167:Immunotherapy; D015260:Neprilysin; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology* / Q000628:therapy; D011863:Radioimmunoassay
chemical_list: D000912:Antibodies, Neoplasm; D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D015260:Neprilysin