title: Effects of isradipine, a new calcium antagonist, versus hydrochlorothiazide on serum lipids and apolipoproteins in patients with systemic hypertension.
abstract: The effect of isradipine versus hydrochlorothiazide on the lipid profile of 44 hypertensive patients was investigated in a double-blind, randomized, 2-center trial. Lipid profiles included total cholesterol, serum triglycerides, high density lipoprotein (HDL) cholesterol, HDL subclasses, (HDL2 and HDL3), low density lipoprotein cholesterol, very low density lipoprotein cholesterol, apolipoprotein A-1 and apolipoprotein B. Isradipine had no effect on the lipid profile in short- (4 and 10 week) or long-term (52 week) studies. Hydrochlorothiazide increased serum triglycerides in 11 of 13 patients by a mean of 8% for the group (p less than 0.05) in long-term (52 week) studies, and total cholesterol by a mean of 9 and 16%, respectively (p less than 0.01) in 2 of 13 patients, with no difference in other lipid or lipoprotein parameters in short- or long-term studies.
authors.affiliation: Long Island Jewish Medical Center, Manhasset, New York 11030.
authors.forename: P
authors.initials: P
authors.lastname: Samuel
authors.forename: W
authors.initials: W
authors.lastname: Kirkendall
authors.forename: E J
authors.initials: EJ
authors.lastname: Schaefer
authors.forename: B
authors.initials: B
authors.lastname: Chin
authors.forename: B H
authors.initials: BH
authors.lastname: Schoenfeld
authors.forename: L M
authors.initials: LM
authors.lastname: Gonasun
authors.forename: S
authors.initials: S
authors.lastname: Lieberman
mesh_terms: D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000097:blood*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D017275:Isradipine; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011725:Pyridines / Q000627:therapeutic use*; D011897:Random Allocation; D013997:Time Factors
chemical_list: D001053:Apolipoproteins; D002121:Calcium Channel Blockers; D008055:Lipids; D011725:Pyridines; D006852:Hydrochlorothiazide; D017275:Isradipine