Evaluation of the sensitising potential of 4 polyamines present in technical triethylenetetramine using 2 animal species.
Contact sensitivity to 4 polyamines present in technical grade triethylenetetramine was investigated using the 'VAA mouse' assay and the guinea pig maximization test (GPMT). The criteria used to assess sensitivity in the GPMT classed all substances as having the same degree of sensitising potential. The mouse assay ranked N-(2-piperazin-1-ylethyl)ethylenediamine as having a significantly greater sensitising potential than the other compounds.
Maisey
J
J
British Industrial Biological Research Association, Carshalton, Surrey, UK.
Purchase
R
R
Robbins
M C
MC
Miller
K
K
D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000139:chemically induced; D005029:Ethylenediamines / Q000009:adverse effects*; D005260:Female; D006168:Guinea Pigs; D051379:Mice; D008807:Mice, Inbred BALB C; D011073:Polyamines / Q000276:immunology / Q000633:toxicity*; D012882:Skin Tests; D014266:Trientine / Q000009:adverse effects*
D005029:Ethylenediamines; D011073:Polyamines; D014266:Trientine