The effect of a long-acting somatostatin analogue (SMS 201-995) on intermediary metabolism and gut hormones after a test meal in normal subjects.
SMS 201-995 is an octapeptide analogue of somatostatin. The effect of a single subcutaneous (s.c.) injection of 50 micrograms SMS 201-995 on post-prandial intermediary metabolism was investigated in normal subjects. In spite of a long-lasting post-prandial suppression of insulin secretion, there were no significant changes in the plasma concentration of alanine, glycerol, 3-OH-butyrate or lactate. However, SMS 201-995 impairs carbohydrate tolerance, probably due to inhibition of insulin secretion. Basal and post-prandial plasma concentrations of the gut regulatory peptides pancreatic glucagon, motilin, pancreatic polypeptide, gastric inhibitory polypeptide, enteroglucagon, gastrin and peptide YY were suppressed up to 5 hours after subcutaneous administration of a single dose of SMS 201-995.
Fuessl
H S
HS
Department of Medicine, Royal Postgraduate Medical School, London, UK.
Burrin
J M
JM
Williams
G
G
Adrian
T E
TE
Bloom
S R
SR
D020155:3-Hydroxybutyric Acid; D000328:Adult; D000409:Alanine / Q000097:blood; D005502:Food; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D005990:Glycerol / Q000097:blood; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007773:Lactates / Q000097:blood; D015282:Octreotide / Q000494:pharmacology*
D005768:Gastrointestinal Hormones; D006885:Hydroxybutyrates; D007773:Lactates; D000409:Alanine; D005990:Glycerol; D015282:Octreotide; D020155:3-Hydroxybutyric Acid