title: Generalized eruption with severe liver dysfunction associated with occupational exposure to trichloroethylene.
abstract: Generalized dermatitis due to trichloroethylene is rare. A 21-year-old printer developed exfoliative dermatitis with mucous membrane involvement, fever and liver dysfunction after a 2-week occupational exposure to trichloroethylene. Positive patch-test reactions to trichloroethylene and to one of its metabolites, trichloroethanol, were observed. This dermatitis is considered to be mediated by a delayed-type hypersensitivity mechanism.
authors.affiliation: Department of Dermatology, Metropolitan Bokutoh Hospital, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Ageishi
authors.forename: T
authors.initials: T
authors.lastname: Takano
mesh_terms: D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D009783:Dermatitis, Occupational / Q000209:etiology*; D005023:Ethylene Chlorohydrin / Q000009:adverse effects / Q000031:analogs & derivatives; D006801:Humans; D006968:Hypersensitivity, Delayed; D007564:Japan; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*; D010328:Patch Tests / Q000379:methods; D013203:Staphylococcal Infections / Q000209:etiology; D014241:Trichloroethylene / Q000009:adverse effects*
chemical_list: D014241:Trichloroethylene; D005023:Ethylene Chlorohydrin; C005849:2,2,2-trichloroethanol