Some biochemical observations on gluconeogenesis from propionate in hepatocytes isolated from normal and biotin-deficients rats.
Propionate and pyruvate added to isolated normal and biotin-deficient adult rat hepatocytes increase the production of glucose. This production decreases about 30% on biotin deficiency. Malonate inhibits gluconeogenesis from propionate showing the metabolic transformation of propionyl-CoA via the Krebs cycle. Neither glucagon nor dibutyryl-cyclic AMP significantly stimulate gluconeogenesis.
Djabal
A
A
Mangeot
M
M
Cherruau
B
B
Lemonnier
A
A
D000818:Animals; D001710:Biotin / Q000172:deficiency*; D003994:Bucladesine / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D005934:Glucagon / Q000494:pharmacology; D005943:Gluconeogenesis / Q000187:drug effects*; D008099:Liver / Q000378:metabolism*; D008297:Male; D011422:Propionates / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011422:Propionates; D011773:Pyruvates; D003994:Bucladesine; D001710:Biotin; D019289:Pyruvic Acid; D005934:Glucagon