title: Some pharmacological properties and subacute and chronic toxicity of tryptamide.
abstract: Studies on Albino Swiss mice and Wistar rats have demonstrated that tryptamide is less ulcerogenic than phenylbutazone, and markedly inhibits intestinal peristalsis. Both compounds have a similar tendency to accumulate in the body. Tryptamide produces a smaller hypotension and stimulates the respiratory amplitude to a lesser extent than phenylbutazone in a vivisectional experiment. Studies on the subacute and chronic toxicity have demonstrated that tryptamide administered orally (po) and intraperitioneally (ip) for 3 weeks, and orally for 3 months neither affects the body weight gain or the mass of internal organs, nor changes the locomotor activity; only in rats it disturbs the motor coordination. After ip administration tryptamide shows a moderate depressant effect on the bone marrow, evidenced by a decline in the blood hemoglobin content and the number of erythrocytes and blood platelets. As those changes were more pronounced after a 3-week than a 3-month administration, the observed effects are apparently reversible.
authors.affiliation: Department of Pharmacology, Medical Academy, Lublin, Poland.
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
authors.forename: M
authors.initials: M
authors.lastname: Sieklucka
authors.forename: G
authors.initials: G
authors.lastname: Rajtar
authors.forename: S J
authors.initials: SJ
authors.lastname: Czuczwar
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004562:Electrocardiography; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D007422:Intestines / Q000187:drug effects / Q000502:physiology; D007928:Lethal Dose 50; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D009929:Organ Size / Q000187:drug effects; D010528:Peristalsis; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects; D000637:Transaminases / Q000097:blood; D014363:Tryptamines / Q000494:pharmacology* / Q000633:toxicity; D014599:Uterus / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014363:Tryptamines; D009536:Niacinamide; C057564:tryptamide; D000637:Transaminases