title: Ventricular myosin of the shrew Crocidura russula, correlation with contractile properties.
abstract: The present study demonstrates that in the shrew ventricular muscle the speed of tension development and relaxation, as well as twitch duration, are much shorter than in the guinea-pig. It also shows that ventricular myosin of the shrew has a high Ca2+-activated ATPase activity and that it is composed of alpha-type heavy chains. Namely, the native molecule is a V1 variety of myosin. These findings advance our knowledge on an as yet uncharacterized mammalian heart and further demonstrate the correlation between mechanical properties and myosin type in heart muscle.
authors.affiliation: Rogoff Medical Research Institute, Beilinson Medical Center, Petah Tikva, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Kessler-Icekson
authors.forename: H
authors.initials: H
authors.lastname: Schlesinger
authors.forename: J J
authors.initials: JJ
authors.lastname: Leger
authors.forename: J
authors.initials: J
authors.lastname: Leger
authors.forename: Y
authors.initials: Y
authors.lastname: Braverman
authors.forename: O
authors.initials: O
authors.lastname: Binah
mesh_terms: D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009200:Myocardial Contraction; D015879:Myosin Subfragments; D009218:Myosins / Q000302:isolation & purification / Q000378:metabolism*; D010446:Peptide Fragments / Q000302:isolation & purification / Q000378:metabolism; D012788:Shrews / Q000502:physiology*; D013045:Species Specificity; D016276:Ventricular Function
chemical_list: D015879:Myosin Subfragments; D010446:Peptide Fragments; D009218:Myosins; D000252:Calcium-Transporting ATPases