[The existence on the serotonin carrier of 2 independent sites for the specific binding of trazodone and imizin].
A combined effect of zimelidine or trazodone on (3H)-serotonin uptake by the rat brain synaptosomes in the presence of 120 nM imipramine was studied. Imipramine and zimelidine were found to inhibit (3H)-serotonin uptake by a competitive manner, whereas trazodone was a noncompetitive inhibitor. Zimelidine, but not trazodone, was shown to bind to serotonin carrier at the same site as imipramine.
Katanasov
A B
AB
Brusov
O S
OS
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D007099:Imipramine / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D014196:Trazodone / Q000493:pharmacokinetics*; D015031:Zimeldine / Q000493:pharmacokinetics
D011985:Receptors, Serotonin; D012701:Serotonin; D015031:Zimeldine; D007099:Imipramine; D014196:Trazodone
O sushchestvovanii na serotoninovom perenoschike dvukh nezavisimykh mest spetsificheskogo sviazyvaniia trazodona i imizina.