title: Effect of treatment with sodium valproate on plasma adrenocorticotropic hormone and cortisol concentrations in pregnancy.
abstract: To investigate whether treatment with valproic acid in pregnancy decreases adrenocorticotropic hormone and cortisol secretion, we measured their concentrations in maternal and umbilical cord blood from a patient receiving valproic acid. We found them to be normal. Valproic acid may not decrease adrenocorticotropic hormone/cortisol levels in pregnant patients or their fetuses.
authors.forename: C G
authors.initials: CG
authors.lastname: Hatjis
authors.forename: J C
authors.initials: JC
authors.lastname: Rose
authors.forename: C
authors.initials: C
authors.lastname: Pippitt
authors.forename: M
authors.initials: M
authors.lastname: Swain
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D004831:Epilepsies, Myoclonic / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005333:Fetus / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000188:drug therapy*; D014635:Valproic Acid / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D014635:Valproic Acid; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone