[Targeting chemotherapy of colorectal cancer by monoclonal antibody conjugated antitumor drug].
Neocarzinostatin (NCS) was conjugated with mouse monoclonal antibody (A7) that specifically reacted with human colorectal carcinomas in vivo and the conjugates (A7-NCS) were administered to patients with colorectal carcinoma. In several cases the size of the metastatic liver tumor was decreased after intraarterial infusion of A7-NCS. No severe adverse effects were observed in any patients who received A7-NCS. These results suggest that missile cancer chemotherapy using monoclonal antibody as a carrier of anticancer drug will be a promising method for use against cancer.
Yamaguchi
T
T
Dept. of Surgery, Kyoto Prefectural University of Medicine.
Takahashi
T
T
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D000922:Immunotoxins / Q000627:therapeutic use*; D007261:Infusions, Intra-Arterial; D009353:Zinostatin / Q000008:administration & dosage
D000970:Antineoplastic Agents; D000922:Immunotoxins; D009353:Zinostatin