[The influence of diphosphonic analogues of inorganic pyrophosphate on reactions catalyzed by DNA-dependent RNA-polymerase II].
Diphosphonic analogues of inorganic pyrophosphate were studied for their influence both on RNA pyrophosphorolysis and pyrophosphate exchange, catalyzed by purified DNA-dependent RNA-polymerase II from calf thymus. Methylene-, oxyethylene-and aminomethylenediphosphonic acids are shown to compete with PPi for incorporation into nucleoside triphosphate. They activate RNA pyrophosphorolysis in the concentration of 2 mM, but to a less extent than PPi does.
Komissarenko
S V
SV
Kolesnikova
I N
IN
Fomovskaia
G N
GN
D000818:Animals; D001667:Binding, Competitive; D002417:Cattle; D011756:Diphosphates / Q000037:antagonists & inhibitors*; D063065:Organophosphonates / Q000494:pharmacology*; D012319:RNA Polymerase II / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013950:Thymus Gland / Q000201:enzymology*
D011756:Diphosphates; D063065:Organophosphonates; D012319:RNA Polymerase II
Vliianie difosfonovykh analogov neorganicheskogo pirofosfata na reaktsii, kataliziruemye dnk-zavisimoĭ rnk-polimerazoĭ II.