title: A comparison of effects of zearalenone and estradiol benzoate on reproductive function during the estrous cycle in gilts.
abstract: Effects of estradiol benzoate (EB) and zearalenone (Z) on luteal maintenance and plasma hormone concentrations were studied in 45 gilts. Gilts were allocated to receive either 20 mg Z, 2 mg EB or no treatment (C) on d 1 to 5 (T1), 6 to 10 (T2) or 11 to 15 (T3) of an estrous cycle (five per treatment). Onset of estrus was designated as d 0 of the estrous cycle. Zearalenone was added to the daily ration and EB was administered via an intramuscular injection. Blood samples were collected every 10 min over a 4-h period on the first 2 d prior to onset of treatment; the first, third and fifth days of treatment; and the first two and the fifth day after the end of the treatment periods. Gilts receiving EB and Z during T2 and T3 had longer (P less than .05) inter-estrous intervals than C gilts. The range in inter-estrous intervals for Z and EB treatments was 28 to 74 and 27 to 63 d, respectively. Mean plasma progesterone concentrations were elevated (P less than .05) during T2 and T3 in EB and Z-treated gilts when compared with C females. Estradiol benzoate treatment during T2 and T3 reduced (P less than .05) mean plasma luteinizing hormone (LH) concentrations more than C or Z treatments. Mean plasma concentrations of 13, 14-dihydro-, 15-keto-prostaglandin F2 alpha (PGFM) during T3 were higher (P less than .05) in C and Z gilts on d 13 and 15 post-estrus when compared with EB gilts.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Dept. Anim. Sci., University of Missouri, Columbia 65211.
authors.forename: B
authors.initials: B
authors.lastname: Flowers
authors.forename: T
authors.initials: T
authors.lastname: Cantley
authors.forename: B N
authors.initials: BN
authors.lastname: Day
mesh_terms: D000818:Animals; D003340:Corpus Luteum Maintenance / Q000187:drug effects*; D015237:Dinoprost / Q000031:analogs & derivatives*; D004958:Estradiol / Q000494:pharmacology*; D004971:Estrus / Q000502:physiology*; D005260:Female; D007986:Luteinizing Hormone / Q000097:blood; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011460:Prostaglandins F / Q000097:blood; D012118:Resorcinols / Q000494:pharmacology*; D013552:Swine / Q000097:blood / Q000502:physiology*; D015025:Zearalenone / Q000494:pharmacology*
chemical_list: D011460:Prostaglandins F; D012118:Resorcinols; C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D011374:Progesterone; D004958:Estradiol; D015025:Zearalenone; D007986:Luteinizing Hormone; D015237:Dinoprost