Metabolic activation of valproic acid and drug-mediated hepatotoxicity. Role of the terminal olefin, 2-n-propyl-4-pentenoic acid.
Baillie
T A
TA
Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle 98195.
D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism* / Q000633:toxicity; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008862:Microsomes, Liver / Q000378:metabolism; D014635:Valproic Acid / Q000378:metabolism* / Q000633:toxicity
D005229:Fatty Acids, Monounsaturated; C045022:2-propyl-4-pentenoic acid; D014635:Valproic Acid; D003577:Cytochrome P-450 Enzyme System