Effects of acute behavioral stress on plasma and cerebrospinal fluid ACTH and beta-endorphin in rhesus monkeys.
To elucidate the effect of acute behavioral stress on plasma and cerebrospinal fluid (CSF) concentrations of adrenocorticotropic hormone (ACTH) and beta-endorphin, rhesus monkeys were subjected to 30 min of confinement stress. Simultaneous plasma and CSF samples revealed no significant change in CSF ACTH or beta-endorphin up to 120 min after the onset of the stress despite significant elevations in plasma cortisol, ACTH, and beta-endorphin. It is suggested that acute behavioral stress does not alter CSF ACTH or beta-endorphin, and that this information may be clinically useful for future human studies of CSF ACTH and beta-endorphin in neuropsychiatric illnesses.
Kalin
N H
NH
Carnes
M
M
Barksdale
C M
CM
Shelton
S E
SE
Stewart
R D
RD
Risch
S C
SC
D000208:Acute Disease; D000324:Adrenocorticotropic Hormone / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D000818:Animals; D004723:Endorphins / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D013315:Stress, Psychological / Q000378:metabolism*; D001615:beta-Endorphin
D004723:Endorphins; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone