Target cells and thymus microenvironment in the pathogenesis of thymic lymphomas in C57BL/Ka mice.
In C57BL/Ka mice, the induction of thymic lymphomas either by inoculation of radiation leukemia virus (RadLV) or by a split dose irradiation requires complex cellular events: Target cells are found among the population of thymic subcapsular blast cells, or, alternatively, of marrow or spleen prothymocytes; Progression of target cells to lymphoma growth requires a multi-step process, which occurs only within thymic microenvironment; Target cells are rapidly induced as "preleukemic" cells; After inoculation of RadLV, the initial events occur when target cells are in close association with cells of a specialized component of thymic epithelium, i.e., the so-called "nurse cells"; The leukemogenic agents induce damages to the thymic microenvironment itself; Lymphoma prevention by marrow grafting after irradiation results from mechanisms still unknown which inhibit the progression of "preleukemic" cells to neoplastic growth.
Boniver
J
J
Houben-Defresne
M P
MP
Goffinet
G
G
Lenaerts
P
P
Betz
E H
EH
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology; D002472:Cell Transformation, Viral; D006183:H-2 Antigens / Q000276:immunology; D009052:Leukemia Virus, Murine / Q000502:physiology; D007953:Leukemia, Radiation-Induced / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D008223:Lymphoma / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011289:Preleukemia / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D011829:Radiation Dosage; D013953:Thymus Neoplasms / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D014779:Virus Replication
D000954:Antigens, Surface; D006183:H-2 Antigens