Comparison between aerosol and powder delivery system of fenoterol plus ipratropium bromide ('Duovent') in patients with asthma and chronic bronchitis.
A study was carried out in 15 stable asthmatics and 5 patients with partially reversible airflow obstruction to compare the efficacy and tolerability of a single dose of 200 micrograms fenoterol plus 80 micrograms ipratropium bromide ('Duovent') administered either by metered dose aerosol or as a dry powder preparation for inhalation ('Inhalets'). Using a double-dummy technique, patients received each formulation, in random order, on 2 separate days within 1 week. Spirometric measurements were made over a period of 6 hours after the dose. The results showed that a 35% peak improvement in mean FEV1 occurred with each method of administration and there was no statistical difference between responses. Improvements of 25% were sustained for over 4 hours and effects on pulse rate and tremor were similar for both preparations.
Town
G I
GI
Department of Medicine, Wellington Clinical School of Medicine, New Zealand.
D000293:Adolescent; D000328:Adult; D000336:Aerosols; D001249:Asthma / Q000188:drug therapy*; D001286:Atropine Derivatives / Q000008:administration & dosage*; D001991:Bronchitis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011208:Powders
D000336:Aerosols; D001286:Atropine Derivatives; D011208:Powders; D005280:Fenoterol; D009241:Ipratropium