An ultrastructural comparison of mesotheliomas with adenocarcinomas of the lung and breast.
The ultrastructural features of 15 mesotheliomas were compared with those of equal numbers of adenocarcinomas of the lung and of the breast in a double-blind study. Combined quantitative and qualitative features were evaluated to provide criteria for distinguishing among these three tumors, which may present as either primary or metastatic pleural tumors. mesotheliomas could be distinguished from adenocarcinomas of the lung by length of microvilli (mean ratios of length to diameter [LDR], 15.7 and 8.7, respectively; P less than 0.01) and content of tonofilaments. Length of microvilli was also useful in distinguishing mesotheliomas from breast adenocarcinomas (mean LDR, 15.7 and 6.9, respectively; P less than 0.001). Adenocarcinomas of the lung could be distinguished from adenocarcinomas of the breast by tonofilament content and the presence of intracytoplasmic lumina. Combined quantitative and qualitative criteria are essential for maximal ultrastructural discrimination among these tumors.
Warhol
M J
MJ
Corson
J M
JM
D000230:Adenocarcinoma / Q000648:ultrastructure*; D001943:Breast Neoplasms / Q000648:ultrastructure*; D003593:Cytoplasm / Q000473:pathology; D003599:Cytoskeleton / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology; D008175:Lung Neoplasms / Q000648:ultrastructure*; D008654:Mesothelioma / Q000648:ultrastructure*; D008871:Microvilli / Q000473:pathology