A second human calcitonin/CGRP gene.
The calcitonin (CT) gene is alternatively expressed in a tissue-specific fashion producing either the calcium regulatory hormone CT in the thyroid or the neuropeptide calcitonin gene related peptide (CGRP) in the brain. In medullary carcinoma of the thyroid both peptides are produced. We present here evidence for the existence in the human genome of a second CT gene, which is also expressed in human medullary thyroid carcinoma. This gene encodes a second human CGRP, differing from the known human CGRP in 3 of the 37 amino acids.
Steenbergh
P H
PH
Höppener
J W
JW
Zandberg
J
J
Lips
C J
CJ
Jansz
H S
HS
D000595:Amino Acid Sequence; D001483:Base Sequence; D002116:Calcitonin / Q000235:genetics*; D015740:Calcitonin Gene-Related Peptide; D004247:DNA / Q000032:analysis; D004262:DNA Restriction Enzymes / Q000378:metabolism; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis
D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D002116:Calcitonin; D004247:DNA; D004262:DNA Restriction Enzymes; D015740:Calcitonin Gene-Related Peptide