Radiosensitization effects of nicotinamide on malignant and normal mouse tissue.
Inhibitors of the chromatin-associated enzyme adenosine diphosphate ribosyltransferase have been found to inhibit DNA strand rejoining and to potentiate lethality of DNA-damaging agents both in vivo and in vitro. We have in this work examined the radiosensitizing potential of one such inhibitor, nicotinamide, on tumor tissue by using transplanted C3H mouse mammary adenocarcinomas and on normal tissue in a tail-stunting experiment using BALB/cA mice. Our data indicate a radiosensitizing effect of nicotinamide on tumor cells as well as on normal tissue. The data indicate a possible role of adenosine diphosphate ribosyltransferase inhibitors as a sensitizing agent in the radiotherapy of malignant tumors.
Jonsson
G G
GG
Kjellén
E
E
Pero
R W
RW
Cameron
R
R
D000818:Animals; D002250:Carbon Radioisotopes; D005720:Gamma Rays; D008325:Mammary Neoplasms, Experimental / Q000473:pathology / Q000532:radiotherapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009536:Niacinamide / Q000378:metabolism / Q000494:pharmacology*; D009713:Nucleotidyltransferases / Q000037:antagonists & inhibitors; D011065:Poly(ADP-ribose) Polymerases; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D012867:Skin / Q000528:radiation effects
D002250:Carbon Radioisotopes; D011838:Radiation-Sensitizing Agents; D009536:Niacinamide; D011065:Poly(ADP-ribose) Polymerases; D009713:Nucleotidyltransferases