Antiproliferative effect of Hu-interferon-gamma in 674V and J82 bladder carcinoma cell lines.
Hu-IFN-gamma was evaluated in regard to the antiproliferative effect on J82 and 647V bladder cancer cell lines. In addition, the IFN-receptors were determined. There was a significant growth inhibition of J82 as well as 647V at low dose Hu-IFN-g (1 U/ml). The growth inhibition was significantly higher in 647V than in J82. The binding assay for 125J-Hu-IFN-g revealed 870 and 3,000 binding sites for 647V and J82, respectively, indicating that the antiproliferative effect of Hu-IFN-g may not depend on the absolute amount of IFN-receptors, in the two cell lines tested.
Jakse
G
G
Urological Clinic and Policlinic, Technical University, Munich, Federal Republic of Germany.
Marth
C
C
Zechner
J
J
Daxenbichler
G
G
D002277:Carcinoma / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D011971:Receptors, Immunologic / Q000502:physiology; D017471:Receptors, Interferon; D014407:Tumor Cells, Cultured / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000473:pathology*
D011971:Receptors, Immunologic; D017471:Receptors, Interferon; D007371:Interferon-gamma