Mutagenicity testing of ST-film with the Ames test, chromosome test in vitro and micronucleus test in female mice.
The mutagenicity of ST-film and its components polyoxyethylenenonylether (NP-10) and polyvinylalcohol (PVAL) were studied by a reverse mutation test in S. typhimurium (Ames test), a chromosome test in cultured Chinese hamster V 79 cells and a micronucleus test in female mice. The results obtained from these test systems were all negative. Thus, it may be concluded that ST-film is not mutagenic either in vitro or in vivo mutagenicity testing systems.
Shibuya
T
T
Tanaka
N
N
Katoh
M
M
Matsuda
Y T
YT
Morita
K
K
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects*; D002478:Cells, Cultured; D002875:Chromosomes / Q000187:drug effects*; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D017137:Nonoxynol; D011092:Polyethylene Glycols / Q000633:toxicity*; D011142:Polyvinyl Alcohol / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects
D009153:Mutagens; D017137:Nonoxynol; D011092:Polyethylene Glycols; D011142:Polyvinyl Alcohol