[Catecholaminergic receptors of the blood cells of schizophrenics].
The simultaneous determination of serum CA and their receptors in blood cells offers a possibility to evaluate disturbances of the DA and NA neuronal systems in man. High affinity binding sites for 3H-yohimbine in platelets, 3H-DHA on granulocytes and 3H-spiperone in lymphocytes from healthy control persons, unmedicated (n = 28), and medicated (n = 8) schizophrenics as well as from an unmedicated psychiatric control (n = 14) were investigated. Furthermore, the actual concentration of the circulating CA was determined with HPLC-ECD. In unmedicated schizophrenics as compared to controls, specific binding of 3H-spiperone to lymphocytes was markedly elevated in capacity and less in affinity as compared to controls. For beta2-receptors a significant decrease was found in capacity with no change in affinity. The changes in alpha2-receptors with a slight decrease in capacity were less distinct. The concentrations of circulating CA ranged from normal values up to a more than 3 fold increase in NA and DA, whereas A concentrations were practically unchanged. No overall change in these data was found in the medicated schizophrenic patients. 3H-spiperone binding was characteristically increased only in schizophrenics, but did not elevate above control data in the non-schizophrenic psychiatric control group. Preliminary experiments of family studies suggest that this model could be valuable as a vulnerability marker.
Ackenheil
M
M
Bondy
B
B
Fröhler
M
M
Vakis
A
A
D000328:Adult; D001773:Blood Cells / Q000032:analysis*; D001792:Blood Platelets / Q000032:analysis; D002395:Catecholamines / Q000097:blood*; D004298:Dopamine / Q000097:blood; D004837:Epinephrine / Q000097:blood; D005260:Female; D006098:Granulocytes / Q000032:analysis; D006801:Humans; D008214:Lymphocytes / Q000032:analysis; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011941:Receptors, Adrenergic / Q000032:analysis*; D017983:Receptors, Catecholamine; D012559:Schizophrenia / Q000097:blood*
D002395:Catecholamines; D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
Des récepteurs catécholaminergiques aux cellules sanguines des schizophrènes.