A high performance isolated rat brain preparation. Part II. Cerebral blood flow in relation to perfusion pressure and cerebral hypothermia.
The effects of changes of perfusion pressure and hypothermia on the cerebral blood flow of a new isolated rat brain preparation have been studied in 7 animals. The cerebral blood flow was extremely sensitive to the mean arterial pressure of perfusion, showing little evidence of autoregulation at low pressure, and only slight evidence in hypertension. The cerebral blood flow was lower in hypothermia. The preparation maintained good electroencephalographic activity throughout, and arteriovenous differences persisted up to 1 h after it became isoelectric.
Takaoka
Y
Y
White
R J
RJ
Likavec
M J
MJ
D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000502:physiology; D002560:Cerebrovascular Circulation; D004569:Electroencephalography; D005112:Extracorporeal Circulation; D007036:Hypothermia, Induced; D008297:Male; D010477:Perfusion; D011312:Pressure; D051381:Rats; D011919:Rats, Inbred Strains