title: Cryolumpectomy for breast cancer: an experimental study.
abstract: The effects of cryosurgical procedures and surgical excision in preventing the local recurrence of mammary adenocarcinoma were studied in BALB/cfC3H mice carrying syngeneic, virus-induced mammary adenocarcinomas transplanted into the fourth mammary fat pad. In this report we present evidence demonstrating that cryosurgical procedures involving multiple freeze-thaw cycles followed by tumor excision markedly reduce the local recurrence rate of mouse mammary cancer. Surgical resection without cryotreatment resulted in an 80% local recurrence rate; in contrast, cryotreatment consisting of three freeze-thaw cycles before excision prevented local tumor recurrence in 70% of the animals. The use of cryotherapy and local excision (cryolumpectomy) in the treatment of human breast cancer is discussed.
authors.forename: R W
authors.initials: RW
authors.lastname: Rand
authors.forename: R P
authors.initials: RP
authors.lastname: Rand
authors.forename: F A
authors.initials: FA
authors.lastname: Eggerding
authors.forename: M
authors.initials: M
authors.lastname: Field
authors.forename: L
authors.initials: L
authors.lastname: Denbesten
authors.forename: W
authors.initials: W
authors.lastname: King
authors.forename: S
authors.initials: S
authors.lastname: Camici
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000368:Aged; D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000601:surgery; D003452:Cryosurgery; D005260:Female; D005615:Freezing; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000473:pathology / Q000601:surgery*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control