title: Monoclonal antibodies specific for p24, the major core protein of human T-cell leukemia virus type III.
abstract: Four mouse hybridomas secreting monoclonal antibodies specific for p24, the major core antigen of the human T-cell leukemia virus type III (HTLV-III), have been developed, and their specificities have been partially characterized. These antibodies specifically recognized p24 of HTLV-III in extracts of HTLV-III and in HTLV-III-producing cells. No epitopes cross-reactive with HTLV-I and -II were detected with these antibodies. These hybridomas will be extremely valuable reagents in identifying expression of HTLV-III in infected cultures and in cells or tissues from patients with suspected immunodeficiency syndrome.
authors.forename: F
authors.initials: F
authors.lastname: di Marzo Veronese
authors.forename: M G
authors.initials: MG
authors.lastname: Sarngadharan
authors.forename: R
authors.initials: R
authors.lastname: Rahman
authors.forename: P D
authors.initials: PD
authors.lastname: Markham
authors.forename: M
authors.initials: M
authors.lastname: Popovic
authors.forename: A J
authors.initials: AJ
authors.lastname: Bodner
authors.forename: R C
authors.initials: RC
authors.lastname: Gallo
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D000918:Antibody Specificity; D017977:Deltaretrovirus / Q000276:immunology*; D006801:Humans; D008970:Molecular Weight; D014758:Viral Core Proteins; D014764:Viral Proteins / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D014758:Viral Core Proteins; D014764:Viral Proteins