title: Gene dosage effect in cells with monosomy of chromosome 22 derived from human meningiomas.
abstract: Enzymatic determinations of four enzymes, Arylsulphatase A (ARSA), alpha-iduronidase (IDUA), beta-galactosidase (GLB) and hexosaminidase were performed in 19 cases of meningioma. Gene dosage effect was demonstrated for ARSA and IDUA; preliminary evidence for mapping a "protective protein" of GLB in the region 22pter----q11 was also obtained.
authors.affiliation: Biologia generale e Genetica Medica, Università di Pavia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Casalone
authors.forename: A
authors.initials: A
authors.lastname: Minelli
authors.forename: G
authors.initials: G
authors.lastname: Butti
authors.forename: P
authors.initials: P
authors.lastname: Gaetani
authors.forename: V
authors.initials: V
authors.lastname: Silvani
authors.forename: C L
authors.initials: CL
authors.lastname: Solero
authors.forename: C
authors.initials: C
authors.lastname: Danesino
mesh_terms: D001192:Arylsulfatases / Q000032:analysis / Q000235:genetics; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D007068:Iduronidase / Q000032:analysis / Q000235:genetics; D008577:Meningeal Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D008579:Meningioma / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D009006:Monosomy; D014407:Tumor Cells, Cultured; D001616:beta-Galactosidase / Q000032:analysis / Q000235:genetics; D001619:beta-N-Acetylhexosaminidases / Q000032:analysis / Q000235:genetics
chemical_list: D001192:Arylsulfatases; D001616:beta-Galactosidase; D001619:beta-N-Acetylhexosaminidases; D007068:Iduronidase