Age-related reductions in rat atrial high affinity choline uptake, ACh synthesis, and ACh release. A brief note.
We have developed a rat atrial mince preparation that can take up choline, acetylate it, and then release acetylcholine in a depolarization-dependent manner. We demonstrate that aging appears to reduce the functional cholinergic activity in this tissue, which may be important for understanding how senescence alters the regulation of cardiac activity.
Meyer
E M
EM
Esen Momol
A
A
Baker
S P
SP
D000109:Acetylcholine / Q000096:biosynthesis*; D000375:Aging; D000818:Animals; D002794:Choline / Q000378:metabolism*; D006325:Heart Atria / Q000378:metabolism; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D009435:Synaptic Transmission
D002794:Choline; D000109:Acetylcholine