title: Observations on the chemical and physiological properties of urodiolenone, an urinary compound found in hypertension.
abstract: Urodiolenone is a substance that appears as the glucuronide in the urine of 1 in 3 hypertensive subjects. It is a potent inhibitor of Na+, K+-ATPase in kidney tissue of the guinea pig, as measured by cytochemical assay. Chemical and mass spectrometric evidence is presented, from which it is concluded that urodiolenone is a sesquiterpenoid substance, is a bicyclic enone with a vicinal diol side chain, and has molecular formula C15H24O3.
authors.forename: E
authors.initials: E
authors.lastname: Neufeld
authors.forename: B
authors.initials: B
authors.lastname: Sklarz
authors.forename: S
authors.initials: S
authors.lastname: Goldberg
authors.forename: S
authors.initials: S
authors.lastname: Gilad
authors.forename: H
authors.initials: H
authors.lastname: Goldfarb
authors.forename: L
authors.initials: L
authors.lastname: Laurian
authors.forename: D S
authors.initials: DS
authors.lastname: Silverberg
authors.forename: R
authors.initials: R
authors.lastname: Chayen
mesh_terms: D005260:Female; D006801:Humans; D006973:Hypertension / Q000652:urine*; D008297:Male; D013058:Mass Spectrometry; D012717:Sesquiterpenes / Q000494:pharmacology / Q000652:urine*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
chemical_list: D012717:Sesquiterpenes; C044615:urodiolenone; D000254:Sodium-Potassium-Exchanging ATPase