Simian virus 40 small-t antigen-induced theophylline resistance is not mediated by cyclic AMP.
Small-t antigen of simian virus 40 renders CV-1 cells resistant to growth arrest induced by theophylline and other methylxanthines. Elevated levels of cyclic AMP are not involved in growth arrest of CV-1 cells by methylxanthines, and small-t antigen does not alter cyclic AMP levels dramatically after infection.
Renz
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Rundell
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D000818:Animals; D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor / Q000494:pharmacology*; D002478:Cells, Cultured; D005576:Colforsin; D000242:Cyclic AMP / Q000032:analysis / Q000502:physiology*; D004224:Diterpenes / Q000494:pharmacology; D004351:Drug Resistance; D011494:Protein Kinases / Q000032:analysis; D013806:Theophylline / Q000494:pharmacology*; D014764:Viral Proteins / Q000494:pharmacology*
D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor; D004224:Diterpenes; D014764:Viral Proteins; D005576:Colforsin; D013806:Theophylline; D000242:Cyclic AMP; D011494:Protein Kinases