title: Adenoid cystic carcinoma of the nasopharynx after previous adenoid irradiation.
abstract: In 1978, Pratt challenged the otolaryngology community to identify an incidence of malignancy in individuals who have previously received radium therapy to the nasopharyngeal lymphoid tissues. This case report is a direct response to that quest and presents a well documented adenoid cystic carcinoma evolving 23 years after radium applicator treatment to the fossa of Rosenmuller. Although a cause-and-effect relationship cannot be scientifically proven, the case history raises several important questions concerning the stimulating effects of radiation on the later onset of frank malignancy.
authors.forename: R A
authors.initials: RA
authors.lastname: Sofferman
authors.forename: J W
authors.initials: JW
authors.lastname: Heisse
mesh_terms: D003528:Carcinoma, Adenoid Cystic / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D010033:Otitis Media / Q000532:radiotherapy*; D010034:Otitis Media with Effusion / Q000532:radiotherapy*; D011883:Radium / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors; D014056:Tomography, X-Ray
chemical_list: D011883:Radium