Lack of variation over 24-hours in response to stimulation of 5-HT1 receptors in the mouse brain.
Two behavioural measures of activity at 5HT1 receptors in mice: RU 24969-induced hyperactivity and 8OH-DPAT hypothermia, were measured at 3-hr intervals throughout the 12-12 L-D cycle. Neither parameter showed significant circadian variation.
Moser
P C
PC
School of Pharmacy and Pharmacology, University of Bath, U.K.
Redfern
P H
PH
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D002940:Circadian Rhythm / Q000187:drug effects*; D007035:Hypothermia / Q000139:chemically induced; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009281:Naphthalenes / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D007211:Indoles; D009281:Naphthalenes; D011985:Receptors, Serotonin; D013764:Tetrahydronaphthalenes; C025145:5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin