title: Immunoreactive opsin and glial fibrillary acidic protein in persistent hyperplastic primary vitreous.
abstract: An 8-month-old boy had an anterior type of persistent hyperplastic primary vitreous in the right eye. Results of needle biopsy, performed because of elevated intraocular pressure, disclosed clusters of blastic cells. The eye was enucleated on the suspicion of retinoblastoma. Histological examination showed retrolental fibrovascular tissue and retinal dysplasia. Immunoreactive opsin was detected in the innermost structures and in photoreceptor-like cells of rosettes. We conclude that photoreceptor cells differentiated to express opsin, even when neighbouring cells were abnormally arranged. An immunocytochemical study of glial fibrillary acidic protein demonstrated glial proliferation in the inner layer of the retina but not in the preretinal space.
authors.affiliation: Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hara
authors.forename: T
authors.initials: T
authors.lastname: Mito
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Ohmura
authors.forename: K
authors.initials: K
authors.lastname: Mizuno
authors.forename: T
authors.initials: T
authors.lastname: Masuda
mesh_terms: D005123:Eye / Q000378:metabolism / Q000473:pathology*; D015353:Eye Enucleation; D005136:Eye Proteins / Q000378:metabolism*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D006965:Hyperplasia; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012160:Retina / Q000378:metabolism / Q000473:pathology; D017299:Rod Opsins; D014822:Vitreous Body / Q000378:metabolism / Q000473:pathology*
chemical_list: D005136:Eye Proteins; D005904:Glial Fibrillary Acidic Protein; D017299:Rod Opsins