title: A study of adrenal corticol function and its reserve activity in long-acting injectable contraceptive users.
abstract: Adrenal function and its reserve capacity were studied in eighteen healthy non-lactating women who received depot-medroxyprogesterone acetate (DMPA: 9 subjects) and norethisterone enanthate (NET-EN: 9 subjects) as long-acting injectable contraceptives. Methodological assessments included: (i) morning fasting concentration of serum cortisol; (ii) diurnal variation of adrenal corticol activity as evidenced by cortisol concentration in serum samples taken at 0700 and 1600 hours; (iii) urinary free cortisol excretion; and (iv) cortisol response to insulin-induced hypoglycaemia. None of these assessments was significantly altered by contraceptive administration. This finding indicates that the subject's ability to release cortisol in response to a stressful situation, as well as to normal day-to-day activity, was not impaired by these contraceptive steroids.
authors.affiliation: Research Institute for Health Sciences, Chiang Mai University, Thailand.
authors.forename: K
authors.initials: K
authors.lastname: Amatayakul
authors.forename: W
authors.initials: W
authors.lastname: Petpoo
authors.forename: N
authors.initials: N
authors.lastname: Ratanawananukul
authors.forename: O
authors.initials: O
authors.lastname: Tanthayaphinant
authors.forename: S
authors.initials: S
authors.lastname: Tovanabutra
authors.forename: V
authors.initials: V
authors.lastname: Suriyanon
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects / Q000502:physiology*; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004341:Drug Evaluation / Q000592:standards; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007003:Hypoglycemia / Q000139:chemically induced; D007275:Injections, Intravenous / Q000379:methods; D007328:Insulin / Q000097:blood / Q000494:pharmacology; D008525:Medroxyprogesterone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D017258:Medroxyprogesterone Acetate; D009640:Norethindrone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D003271:Contraceptive Agents, Female; D007328:Insulin; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone; C024319:norethindrone enanthate; D009640:Norethindrone; D006854:Hydrocortisone