title: Intestinal permeability to macromolecules during colibacillosis in piglets.
abstract: Intestinal macromolecular permeability to macromolecules was determined in a group of specific pathogen free piglets before and after they were infected experimentally with Escherichia coli. Six hours after the infection all piglets developed a profuse diarrhoea. The urea and total protein concentrations in the serum increased markedly after the onset of diarrhoea. Haemoglobin concentration and PCV decreased steadily during the experiment but blood glucose concentration and lipid composition of the faeces did not change. No structural abnormalities in the jejunal and ileal mucosa were seen. No uptake of macromolecules (40,000 KDa) was found suggesting that molecules with a molecular weight of 40,000 or more do not play a role in the persistent diarrhoea sometimes seen in piglets after colibacillosis.
authors.affiliation: Clinic for Large Animal Medicine, State University of Utrecht, The Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: Vellenga
authors.forename: T
authors.initials: T
authors.lastname: Wensing
authors.forename: H J
authors.initials: HJ
authors.lastname: Egberts
authors.forename: J E
authors.initials: JE
authors.lastname: van Dijk
authors.forename: J M
authors.initials: JM
authors.lastname: Mouwen
authors.forename: H J
authors.initials: HJ
authors.lastname: Breukink
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003967:Diarrhea / Q000378:metabolism / Q000473:pathology / Q000662:veterinary; D004927:Escherichia coli Infections / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D007082:Ileum / Q000473:pathology; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D007457:Iodine Radioisotopes; D007583:Jejunum / Q000473:pathology; D010539:Permeability; D011206:Povidone-Iodine / Q000378:metabolism; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000378:metabolism* / Q000473:pathology
chemical_list: D007457:Iodine Radioisotopes; D011206:Povidone-Iodine