Pregnancy prevention by intravaginal delivery of a progesterone antagonist: RU486 tampon for menstrual induction and absorption.
A progesterone antagonist (RU486) was administered to macaque monkeys by an intravaginal tampon for the achievement of both menstrual induction and absorption. The study was conducted in three parts: (1) postcoital treatment beginning 3 days after potential fertilization; (2) treatment on extended cycle days 34 to 37 after a "missed" menstrual flow after mating; and (3) luteal phase (cycle days 22 to 25) treatment in noncoital cycles. Our findings demonstrate pregnancy prevention and/or interruption when these treatments are employed.
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D000019:Abortifacient Agents / Q000008:administration & dosage*; D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage*; D000818:Animals; D003281:Contraceptives, Postcoital / Q000008:administration & dosage; D004963:Estrenes / Q000008:administration & dosage*; D005260:Female; D008252:Macaca fascicularis; D008253:Macaca mulatta; D052576:Menstrual Hygiene Products; D008600:Menstruation-Inducing Agents / Q000008:administration & dosage*; D015735:Mifepristone; D014621:Vagina
D000019:Abortifacient Agents; D000021:Abortifacient Agents, Steroidal; D003281:Contraceptives, Postcoital; D004963:Estrenes; D008600:Menstruation-Inducing Agents; D015735:Mifepristone