title: Elastic properties of the rat respiratory system related to age.
abstract: The experiments were performed on male rats of the Wistar strain under urethane anaesthesia (1.3 g/kg i.p.). Changes of oesophageal and tracheal pressures were registered in a group of 30 spontaneously breathing, supine rats, of 295 +/- 13 g average body weight during lung inflations with 1-5 ml of air. In another group of 25 rats of 70 +/- 6 g average body weight (young rats) we made the measurements during inflation with volumes 0.5-2 ml. The measurements were also performed in a group of 10 paralyzed, ventilated rats with 347 +/- 24 g average body weight and inflations 1-5 ml. Compliance of the lungs (CL), chest wall (CW) and of the respiratory system (Crs) was calculated from the linear part of the pressure-volume curve during inflation. The results indicate: 1. Cw is significantly (p less than 0.001) higher in young (134.7 ml.kPa-1.kg-1) than in adult rats (44.1 ml.kPa-1.kg-1). CL (related to body weight) is not significantly different in young and adult rats. 2. Cw is significantly (p less than 0.001) higher than CL. 3. No difference was observed in CLs Cw and Crs between paralyzed and spontaneously breathing animals.
authors.affiliation: Institute of Pathological Physiology, Faculty of Paediatrics, Charles University, Prague.
authors.forename: F
authors.initials: F
authors.lastname: Palecek
authors.forename: E
authors.initials: E
authors.lastname: Jezová
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D004548:Elasticity; D004947:Esophagus / Q000502:physiology; D008170:Lung Compliance; D008297:Male; D011312:Pressure; D051381:Rats; D011919:Rats, Inbred Strains; D012143:Respiratory Physiological Phenomena; D014132:Trachea / Q000502:physiology