[Content of cyclic nucleotides, cholesterol and phospholipids in tumors of the large intestine].
Tissues from tumor and normal intestine were examined in 44 patients suffering from colonic and rectal cancer. The study established elevated levels of cholesterol (chiefly, cholesterol esters) and phospholipids, as compared with normal tissue. Two groups were identified among the cancer patients on the basis of the ratio of K = (Formula: see text). Cases with a relatively low value of K revealed higher levels of body fat and hyperlipidemia. That was matched by relatively higher concentrations of cholesterol and its esters, but not phospholipids, in tumor tissue, as compared with normal one. The relationship between cyclic nucleotide metabolism disorders in neoplastic tissue and lipid metabolism in cancer patients is discussed.
Bershteĭn
L M
LM
Kovaleva
I G
IG
Loshakova
L V
LV
Pravosudov
I V
IV
D000230:Adenocarcinoma / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D002788:Cholesterol Esters / Q000378:metabolism; D003110:Colonic Neoplasms / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D010743:Phospholipids / Q000378:metabolism*; D012004:Rectal Neoplasms / Q000378:metabolism*
D002788:Cholesterol Esters; D010743:Phospholipids; D002784:Cholesterol; D000242:Cyclic AMP; D006152:Cyclic GMP
Soderzhanie tsiklicheskikh nukleotidov, kholesterina i fosfolipidov v opukholiakh tolstoĭ kishki.