Shutoff of host translation by encephalomyocarditis virus infection does not involve cleavage of the eucaryotic initiation factor 4F polypeptide that accompanies poliovirus infection.
Studies were conducted to determine whether encephalomyocarditis virus infection causes proteolytic cleavage of any of the polypeptides which comprise eucaryotic initiation factor 4F. Since no such alterations in the components of the initiation factor were detected, these observations confirmed that the mechanisms whereby encephalomyocarditis virus and poliovirus shut off host translation are different.
Mosenkis
J
J
Daniels-McQueen
S
S
Janovec
S
S
Duncan
R
R
Hershey
J W
JW
Grifo
J A
JA
Merrick
W C
WC
Thach
R E
RE
D000818:Animals; D004686:Encephalomyocarditis virus / Q000235:genetics*; D039562:Eukaryotic Initiation Factor-4F; D007739:L Cells; D010448:Peptide Initiation Factors / Q000378:metabolism*; D017955:Poliovirus / Q000235:genetics*; D014176:Protein Biosynthesis
D039562:Eukaryotic Initiation Factor-4F; D010448:Peptide Initiation Factors