title: Partial agonists of the morphine type: facilitative effects on electrophysiologically recorded C-fiber reflexes in the cat.
abstract: The purpose of the present study was to examine the effects of the partial agonists of the morphine type, buprenorphine, profadol and propiram on the spinally-mediated C-fiber reflex. Buprenorphine, profadol and propiram facilitated the C-fiber reflex. In the presence of naltrexone, the effects of buprenorphine were changed to depression of the C-fiber reflex. Profadol and propiram continued to facilitate the C-fiber reflex in the presence of naltrexone. The present results suggest that buprenorphine facilitated the C-fiber reflex by blocking endogenous opioid peptide inhibition of the C-fiber reflex whereas profadol and propiram facilitated it by a non-opioid mechanism.
authors.affiliation: National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224.
authors.forename: J A
authors.initials: JA
authors.lastname: Bell
authors.forename: H E
authors.initials: HE
authors.lastname: Shannon
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002047:Buprenorphine / Q000494:pharmacology*; D002415:Cats; D003655:Decerebrate State; D005260:Female; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*
chemical_list: D000700:Analgesics; D011725:Pyridines; D011759:Pyrrolidines; D002047:Buprenorphine; C002107:propiram