title: [Inhibiting effect of a chalone-containing extract of calf pancreatic tissue on the proliferative activity of normal and tumorous pancreatic cells in vitro and in vivo].
abstract: The pancreatic chalone has been studied for its effect on the proliferative activity and morphology of normal and tumour cells of the pancreas. These findings in experiments in vitro were confirmed by the data of the in vivo experiments. The results show that pancreatic chalone inhibits cell proliferation, decreases mitotic index and causes morphologic changes in cultivated pancreatic cells.
authors.forename: L N
authors.initials: LN
authors.lastname: Mkrtchian
authors.forename: T S
authors.initials: TS
authors.lastname: Khachaturova
authors.forename: S G
authors.initials: SG
authors.lastname: Shukurian
authors.forename: K A
authors.initials: KA
authors.lastname: Aleksanian
authors.forename: R B
authors.initials: RB
authors.lastname: Melik-Shakhnazarian
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003864:Depression, Chemical; D004353:Drug Evaluation, Preclinical; D006131:Growth Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008938:Mitosis / Q000187:drug effects; D010179:Pancreas / Q000166:cytology / Q000187:drug effects*; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D006131:Growth Inhibitors
vernacular_title: Ingibiruiushchiĭ éffekt keĭlonosoderzhashchego ékstrakta iz tkani podzheludochnoĭ zhelezy teliat na proliferativnuiu aktivnost' normal'nykh i opukholevykh kletok podzheludochnoĭ zhelezy in vitro i in vivo.