Age-related changes of methionine-enkephalin and beta-endorphin/beta-lipotropin immunoreactivity in human CSF.
Methionine-enkephalin (ME-IR) and beta-endorphin (BE-IR) immunoreactive material CSF concentrations have been measured in subjects of different ages affected by lumbar or cervical disk hernia. The two peptides exhibited different age-related trends. ME-IR levels rose significantly with age while no changes were observed in the case of BE-IR.
Alessio
L
L
Department of Neurotraumatology, University of Padua, Italy.
Govoni
S
S
Salar
G
G
Battaini
F
F
Iavicoli
R
R
Trabucchi
M
M
D000328:Adult; D000368:Aged; D000375:Aging / Q000134:cerebrospinal fluid*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004744:Enkephalin, Methionine / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay / Q000379:methods; D001615:beta-Endorphin / Q000134:cerebrospinal fluid*; D008083:beta-Lipotropin / Q000134:cerebrospinal fluid*
D004744:Enkephalin, Methionine; D001615:beta-Endorphin; D008083:beta-Lipotropin