title: Influence of hydrochlorothiazide on the pain threshold and on the antinociceptive activity of morphine, in rats.
abstract: Hydrochlorothiazide, acutely injected in rats, has a weak analgesic activity per se and potentiates and prolongs the antinociceptive effect of morphine.
authors.forename: R
authors.initials: R
authors.lastname: Poggioli
authors.forename: A V
authors.initials: AV
authors.lastname: Vergoni
authors.forename: A
authors.initials: A
authors.lastname: Bertolini
mesh_terms: D000818:Animals; D004357:Drug Synergism; D006852:Hydrochlorothiazide / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology; D012964:Sodium / Q000502:physiology
chemical_list: D011957:Receptors, Opioid; D006852:Hydrochlorothiazide; D009020:Morphine; D012964:Sodium