title: Immature teratoma of the ovary with predominant malignant retinal anlage component. A parthenogenically derived tumor.
abstract: An immature teratoma with predominant malignant retinal anlage component occurred in the ovary of a 17-year-old woman. Karyotype analysis from Q-banded preparations revealed that the tumor was parthenogenically derived and exhibited chromosome instability and aneuploidy. On light-microscopical examination, the malignant elements resembled retinal anlage. Ultrastructurally, large, polygonal, pigmented cells had features of ependymal epithelium: a continuous, well-developed basal lamina; microvilli; parallel arrays of rough endoplasmic reticulum; and very large, densely pigmented melanosomes. Adjacent cells identified by light microscopy as immature neuroglia contained glial fibrillary acidic protein by immunohistochemical staining. The presence of neuroglia, not a feature of tumors of neural crest origin, and the ependymal characteristics of the pigmented cells indicate that the neoplasm was most likely of neural groove derivation.
authors.forename: M E
authors.initials: ME
authors.lastname: King
authors.forename: J P
authors.initials: JP
authors.lastname: Micha
authors.forename: S L
authors.initials: SL
authors.lastname: Allen
authors.forename: J A
authors.initials: JA
authors.lastname: Mouradian
authors.forename: R S
authors.initials: RS
authors.lastname: Chaganti
mesh_terms: D000293:Adolescent; D003884:Dermoid Cyst / Q000473:pathology; D005260:Female; D006801:Humans; D007621:Karyotyping; D009364:Neoplasm Recurrence, Local; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology* / Q000648:ultrastructure; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D013724:Teratoma / Q000473:pathology* / Q000648:ultrastructure