title: Twenty-four-hour intragastric acidity and clinical trial of bedtime enprostil 70 micrograms compared with ranitidine 300 mg in duodenal ulcer.
abstract: The effects of bedtime 70 micrograms and twice daily 35 micrograms doses of enprostil on 24-hour intragastric acidity were investigated in nine duodenal ulcer patients in remission. Median nocturnal acidity decreased significantly by 30% with 35 micrograms twice daily, and by 48% with 70 micrograms at bedtime. In a clinical trial using bedtime dosing, 102 duodenal ulcer patients randomly received either ranitidine 300 mg or enprostil 70 micrograms. More ulcers healed after 4 and 8 weeks treatment with ranitidine than with enprostil (76% ranitidine vs 52% enprostil, at 4 weeks p = 0.0065 and 94% vs 68%, respectively at 8 weeks, P = 0.0007). However, 6 months after cessation of treatment there was no material difference in overall outcome. Despite combining mucosal protection with acid inhibition enprostil treatment conferred no advantage over simple acid inhibition.
authors.affiliation: Department of Therapeutics, City Hospital, Nottingham, UK.
authors.forename: R P
authors.initials: RP
authors.lastname: Walt
authors.forename: R E
authors.initials: RE
authors.lastname: Pounder
authors.forename: C J
authors.initials: CJ
authors.lastname: Hawkey
authors.forename: I A
authors.initials: IA
authors.lastname: Santana
authors.forename: K W
authors.initials: KW
authors.lastname: Somerville
authors.forename: R F
authors.initials: RF
authors.lastname: Logan
authors.forename: R G
authors.initials: RG
authors.lastname: Long
authors.forename: M J
authors.initials: MJ
authors.lastname: Langman
mesh_terms: D000328:Adult; D000368:Aged; D002940:Circadian Rhythm; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000503:physiopathology; D016620:Enprostil / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D006801:Humans; D008297:Male; D008875:Middle Aged; D011899:Ranitidine / Q000627:therapeutic use*
chemical_list: D011899:Ranitidine; D016620:Enprostil