Antagonism of V2-receptor effect of antidiuretic hormone by atrial natriuretic peptide in man.
Human alpha-atrial natriuretic peptide (h-alpha ANP) makes the urine of dehydrated volunteers hypotonic to plasma despite high circulating concentrations of antidiuretic hormone. Urinary dilution with h-alpha ANP also occurs in subjects receiving indomethacin. Therefore, h-alpha ANP antagonises effects of antidiuretic hormone on distal tubular V2-receptors in man, probably without involving prostaglandins.
Brown
J
J
Royal Postgraduate Medical School, London, England.
Forsling
M L
ML
Valdes
G
G
Slater
J D
JD
Dollery
C T
CT
D001127:Arginine Vasopressin / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000494:pharmacology*; D001769:Blood; D003681:Dehydration / Q000097:blood / Q000652:urine*; D004231:Diuresis / Q000187:drug effects; D006801:Humans; D007213:Indomethacin; D008297:Male; D009994:Osmolar Concentration; D011945:Receptors, Angiotensin / Q000187:drug effects / Q000502:physiology*; D017483:Receptors, Vasopressin; D012083:Renin / Q000097:blood; D014556:Urine; D014667:Vasopressins / Q000037:antagonists & inhibitors*
D011945:Receptors, Angiotensin; D017483:Receptors, Vasopressin; D014667:Vasopressins; D001127:Arginine Vasopressin; D009320:Atrial Natriuretic Factor; D012083:Renin; D007213:Indomethacin