Effect of vitamin D3 on imaging of experimental myocardial infarcts with technetium-99m pyrophosphate: further studies of the role of calcium.
We previously found that a pulse dose of vitamin D3 increased [99mTc]PPi uptake by rat myocardial necrosis. Vitamin D3 raised serum and lesion [Ca] but not, we now report, lesion [Fe]. We now also report that D3 increased [99Tc]PPi uptake by myocardial infarcts (L) in dogs from 0.345 +/- 0.007% administered (kg) dose/g in controls to 0.703 +/- 0.089 in treated (p less than 0.025). Vitamin D3 decreased uptake by dog bone (B) as measured in rib and sternum, increasing L/B from 1.10 +/- 0.23 to 2.30 +/- 0.52 (p = 0.06) X (L) was positively, (p less than 0.005) and uptake by sternum was negatively (p less than 0.05) correlated with serum [Ca] and [P], respectively. Scintigrams graded by a "blinded" observer, showed 4+, 4+, and 3+ infarcts, respectively, in three D3-treated dogs, and 2+, 2+, and 1+, respectively, in three untreated. One untreated and one treated dog were negative; the latter showed the least response to D3 in serum [Ca] and [99mTc] in tissue samples. Vitamin D3 can increase L/B in dogs, enhancing scintigraphic images.
Carr
E A
EA
Carroll
M
M
Gona
J M
JM
Balderman
S C
SC
Montes
M
M
Steinbach
J J
JJ
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002762:Cholecalciferol / Q000494:pharmacology*; D011756:Diphosphates / Q000378:metabolism; D004285:Dogs; D007501:Iron / Q000378:metabolism; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium / Q000378:metabolism; D016698:Technetium Tc 99m Pyrophosphate
D011756:Diphosphates; D002762:Cholecalciferol; D010758:Phosphorus; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium; D007501:Iron; D002118:Calcium