Effect of propofol, thiopentone and etomidate on adrenal steroidogenesis in vitro.
The i.v. anaesthetic agents propofol, thiopentone and etomidate inhibited ACTH-stimulated production of cortisol by guineapig dispersed adrenal cells in a dose-related manner. For two of the drugs, propofol and thiopentone, inhibition occurred over a similar concentration range: 2 X 10(-5) - 5 X 10(-4) mol litre-1. With etomidate, inhibition occurred over a much lower concentration range (5 X 10(-8) - 5 X 10(-6) mol litre-1). The concentrations of anaesthetic which induced 50% inhibition of cortisol secretion were propofol 1.7 X 10(-4), thiopentone 1.6 X 10(-4), and etomidate 1.0 X 10(-7) mol litre-1.
Lambert
A
A
Mitchell
R
R
Robertson
W R
WR
D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005045:Etomidate / Q000494:pharmacology*; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000096:biosynthesis*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D010636:Phenols / Q000494:pharmacology*; D015742:Propofol; D013874:Thiopental / Q000494:pharmacology*
D000777:Anesthetics; D007093:Imidazoles; D010636:Phenols; D000324:Adrenocorticotropic Hormone; D013874:Thiopental; D006854:Hydrocortisone; D015742:Propofol; D005045:Etomidate