T-cell gene rearrangements and the diagnosis of T-cell neoplasms.
Rearrangements of the T-cell antigen receptor genes serve as unique, clonal tumor markers of T-cell neoplasms. This approach provides a reliable and sensitive diagnostic tool to document both clonality and lineage of T-cell lymphoproliferative processes.
Cossman
J
J
Hematopathology Section, National Cancer Institute, Bethesda, Maryland.
Uppenkamp
M
M
D000818:Animals; D006801:Humans; D007938:Leukemia / Q000175:diagnosis*; D008223:Lymphoma / Q000175:diagnosis*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D011995:Recombination, Genetic; D013601:T-Lymphocytes / Q000648:ultrastructure
D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta