Inhibitory effect of cephalosporins on gamma-aminobutyric acid receptor binding in rat synaptic membranes.
Cephalosporins inhibited gamma-aminobutyric acid receptor binding in a concentration-dependent manner in vitro. Scatchard analysis revealed that cefazolin decreased the binding capacity but did not change the affinity of the receptor. It is suggested that this inhibition of gamma-aminobutyric acid receptor binding may be involved in the induction of convulsions by cephalosporins.
Hori
S
S
Kurioka
S
S
Matsuda
M
M
Shimada
J
J
D000818:Animals; D002511:Cephalosporins / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism; D013570:Synaptic Membranes / Q000187:drug effects / Q000378:metabolism*
D002511:Cephalosporins; D011963:Receptors, GABA-A; D010424:Pentobarbital