title: A comparison of Cleocin T Solution, Cleocin T Gel, and placebo in the treatment of acne vulgaris.
abstract: A twelve-week study in which investigators were blinded to the agents studied included 135 patients (aged twelve to thirty-five years) with moderately severe acne vulgaris. Patients were randomized into groups to compare the efficacy and local tolerance of 1 percent clindamycin phosphate gel, 1 percent clindamycin phosphate solution, and the gel vehicle which served as a placebo. One hundred and twenty-eight patients who completed at least six weeks of treatment were evaluated for efficacy of these agents. Both the solution and the gel were equivalent in reducing papule and pustule counts and results were superior to those produced by the placebo. All three treatments were tolerated well.
authors.affiliation: Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0314.
authors.forename: C N
authors.initials: CN
authors.lastname: Ellis
authors.forename: W R
authors.initials: WR
authors.lastname: Gammon
authors.forename: D Z
authors.initials: DZ
authors.lastname: Stone
authors.forename: J L
authors.initials: JL
authors.lastname: Heezen-Wehner
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002648:Child; D002981:Clindamycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D005782:Gels; D006801:Humans; D011897:Random Allocation; D012996:Solutions
chemical_list: D005782:Gels; D012996:Solutions; D002981:Clindamycin; C007084:clindamycin phosphate