Cytological localization of adenosine kinase, nucleoside phosphorylase-1, and esterase-10 genes on mouse chromosome 14.
We have determined the regional locations on mouse chromosome 14 of the genes for mouse adenosine kinase (ADK), nucleoside phosphorylase-1 (NP-1), and esterase-10 (ES-10) by analysis of rearranged mouse chromosomes in gamma-irradiated Chinese hamster X mouse hybrid cell lines. Irradiated clones were screened for expression of the murine forms of these enzymes; segregant clones that expressed only one or two of the three markers were karyotyped. The patterns of enzyme expression in these segregants were correlated with the presence of rearranged chromosomes. The Adk gene was localized to bands A2 to B, Np-1 to bands B to C1, and Es-10 to bands D2 to E2.
Samuelson
L C
LC
Farber
R A
RA
D000248:Adenosine Kinase / Q000235:genetics*; D000818:Animals; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000235:genetics*; D002459:Cell Fusion; D002460:Cell Line; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D002875:Chromosomes / Q000528:radiation effects; D006224:Cricetinae; D004622:Embryo, Mammalian; D005260:Female; D005347:Fibroblasts; D005720:Gamma Rays; D006822:Hybrid Cells / Q000528:radiation effects / Q000648:ultrastructure; D051379:Mice; D010053:Ovary; D010430:Pentosyltransferases / Q000235:genetics*; D010770:Phosphotransferases / Q000235:genetics*; D011683:Purine-Nucleoside Phosphorylase / Q000235:genetics*
D010430:Pentosyltransferases; D011683:Purine-Nucleoside Phosphorylase; D010770:Phosphotransferases; D000248:Adenosine Kinase; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase