Potency and efficacy of inactivated bluetongue virus vaccines.
Bluetongue virus (BTV) was chemically inactivated and was shown to elicit neutralizing antibodies in vaccinated rabbits and sheep. In sheep, the neutralizing antibody was shown to be protective by immunity challenge with virulent virus. These studies have shown the feasibility of safe and effective inactivated vaccines for bluetongue (BT) disease of sheep.
Stevens
D R
DR
Stott
J
J
Osburn
B I
BI
Giles
R
R
Wiesehahn
G P
GP
Barber
T L
TL
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001819:Bluetongue / Q000517:prevention & control*; D001820:Bluetongue virus / Q000276:immunology*; D011817:Rabbits; D012087:Reoviridae / Q000276:immunology*; D012756:Sheep / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D014765:Viral Vaccines