Suppression of simian immunodeficiency virus replication in vitro by CD8+ lymphocytes.
The AIDS-like disease in rhesus monkeys induced by the simian immunodeficiency virus (SIV) has been used as a model to explore the nature of the T lymphocyte response after infection with viruses of the human immunodeficiency virus family. Activated CD8+ lymphocytes are present in increased numbers in the paracortex of lymph nodes of SIV-infected rhesus monkeys with a lymphadenopathy syndrome. We demonstrate that SIV is more readily isolated from CD8+ lymphocyte-depleted PBL of SIV-infected animals than from their unfractionated PBL. Rather than reflecting the fact that the CD8+ lymphocyte-depleted cell populations are simply enriched for CD4+ lymphocytes, this indicates that CD8+ cells themselves are critical in this regulatory interaction. In fact, CD8+ lymphocytes from SIV-infected but not uninfected rhesus monkeys can block SIV replication in vitro in PBL populations. A T lymphocyte population that blocks replication of viruses of the HIV family may contribute to containing the progression of AIDS.
Kannagi
M
M
Harvard Medical School, New England Regional Primate Research Center, Southborough, MA 01772.
Chalifoux
L V
LV
Lord
C I
CI
Letvin
N L
NL
D000386:AIDS-Related Complex / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D002460:Cell Line; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008251:Macaca / Q000276:immunology*; D008253:Macaca mulatta / Q000276:immunology*; D010641:Phenotype; D012190:Retroviridae / Q000254:growth & development* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology*; D014779:Virus Replication
D000945:Antigens, Differentiation, T-Lymphocyte