title: Spin state studies on cytochrome P-450 in liver microsomes from obese and diabetic animals.
abstract: The spin state of liver microsomal cytochrome P-450 from obese mice and streptozotocin-diabetic mice and rats has been studied both by the temperature and the type I substrates-induced spectral changes. The high spin cytochrome P-450 is significantly decreased in these animals. Moreover absolute spectra indicate that low spin cytochrome P-450 is stabilized in streptozotocin induced-diabetic animals. Thus the physiopathological state may modify the in vivo spin state of cytochrome P-450 and modifications of the microsomal fatty acid composition might contribute to these changes.
authors.forename: E
authors.initials: E
authors.lastname: Rouer
authors.forename: M
authors.initials: M
authors.lastname: Delaforge
authors.forename: F
authors.initials: F
authors.lastname: Rocchiccioli
authors.forename: G G
authors.initials: GG
authors.lastname: Gibson
authors.forename: J P
authors.initials: JP
authors.lastname: Leroux
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System; D003920:Diabetes Mellitus / Q000201:enzymology*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D004578:Electron Spin Resonance Spectroscopy; D005227:Fatty Acids / Q000032:analysis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D008862:Microsomes, Liver / Q000201:enzymology*; D009765:Obesity; D051381:Rats; D011919:Rats, Inbred Strains; D013053:Spectrophotometry
chemical_list: D005227:Fatty Acids; D003577:Cytochrome P-450 Enzyme System