title: Interferons inhibit syncytia-forming ability and in vitro transmission of human T-cell leukemia virus.
abstract: Interferon(IFN)-alpha and -beta strongly inhibited syncytia formation of human T-cell leukemia virus (HTLV). They also inhibited transmission of HTLV to normal human fibroblasts. These phenomena suggest a physiological role of IFNs in defense against HTLV infection.
authors.forename: J
authors.initials: J
authors.lastname: Nishida
authors.forename: H
authors.initials: H
authors.lastname: Yoshikura
authors.forename: T
authors.initials: T
authors.lastname: Okabe
authors.forename: A
authors.initials: A
authors.lastname: Urabe
authors.forename: F
authors.initials: F
authors.lastname: Takaku
mesh_terms: D000818:Animals; D002415:Cats; D017977:Deltaretrovirus / Q000187:drug effects* / Q000378:metabolism; D005347:Fibroblasts / Q000382:microbiology; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007938:Leukemia / Q000635:transmission*; D008715:Methionine / Q000378:metabolism; D014412:Tumor Virus Infections / Q000635:transmission*; D014764:Viral Proteins / Q000096:biosynthesis
chemical_list: D007370:Interferon Type I; D014764:Viral Proteins; D008715:Methionine