Vasorelaxant effects of atriopeptins in human internal mammary artery.
The vasorelaxant effects of the atriopeptins, AP-(103-126) and AP-(103-123) were compared in human internal mammary artery (IMA) rings which had been contracted with norepinephrine. AP-(103-126) completely relaxed the IMA with an IC50 within the physiologically relevant range (15 nM). However, relaxation with AP-(103-123) was greatly reduced compared to AP-(103-126), with complete relaxation observed in only half of the vessels tested and only at concentrations of 10-50 microM. These results indicate that the atriopeptin (AP) receptor in human arteries may be more similar to the AP receptor in rabbit rather than rat arteries.
McMahon
E G
EG
G.D. Searle Research and Development, Washington University School of Medicine, Department of Pharmacology, St. Louis, MO 63110.
Marshall
W G
WG
D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008323:Mammary Arteries / Q000187:drug effects; D008875:Middle Aged; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology
D009320:Atrial Natriuretic Factor; D009638:Norepinephrine