Prostaglandin A2 receptor in rat intestinal basolateral plasma membranes.
The specific prostaglandin A2 receptor was presented in rat intestinal basolateral plasma membrane. The dissociation constant was 4.39 X 10(-8) M and the value of the binding capacity was 3.33 pmol/mg protein. [3H]prostaglandin A2 binding was specifically inhibited by Na+ or ATP. The inhibition manners of Na+ and ATP for [3H]prostaglandin A2 binding were of a competitive and noncompetitive type, respectively.
Matsukawa
R
R
Hayakawa
M
M
Tanaka
M
M
Takiguchi
H
H
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011454:Prostaglandins A / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011982:Receptors, Prostaglandin / Q000378:metabolism*; D012964:Sodium / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D011454:Prostaglandins A; D011956:Receptors, Cell Surface; D011982:Receptors, Prostaglandin; D000255:Adenosine Triphosphate; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; C100008:prostaglandin A2