[Immunological characteristics of patients with diffuse toxic goiter].
Altogether 24 patients with diffuse toxic goiter were examined after surgical intervention and thiamazole therapy. In addition to clinical methods the levels of T- and B-lymphocytes, immunoregulatory cells (T-helpers and T-suppressors) and immunoglobulins of different classes were determined before and after therapy. A method of spontaneous and complementary rosette formation and monoclonal antibodies (Ortho) were used for the determination of the content of T- and B-lymphocytes. Immunoglobulins were determined by a method of radial immunodiffusion in gel. It was shown that in patients with diffuse toxic goiter the level of T-lymphocytes was significantly on a decrease, the levels of B-lymphocytes and IgG were on an increase before therapy. There was sharp disturbance in the ratio of immunoregulatory cells--T-helpers and T-suppressors. After therapy the clinical picture and immunological indices in 14 patients returned to normal, in the rest of 10 patients the Ig level and ratio of immunoregulatory cells remained disturbed.
Sekhniashvili
Z Sh
ZSh
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006111:Graves Disease / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013965:Thyroidectomy
D007136:Immunoglobulins; D008713:Methimazole
Immunologicheskaia kharakteristika bol'nykh diffuznym toksicheskim zobom.