Deregulation of interleukin-2 receptor gene expression in HTLV-I-induced adult T-cell leukemia.
Infection of human T cells by human T-lymphotropic virus, type I (HTLV-I), a retrovirus, is uniformly associated with the constitutive expression of large numbers of cellular receptors for interleukin-2 (IL-2). Comparison with normal T cells shows that neither IL-2 receptor gene organization nor IL-2 receptor messenger RNA processing are altered in the leukemic cells. However, mitogenic stimuli activate IL-2 receptor gene expression in normal T cells, whereas these stimuli paradoxically inhibit IL-2 receptor gene transcription in HTLV-I-infected leukemic T cells.
Krönke
M
M
Leonard
W J
WJ
Depper
J M
JM
Greene
W C
WC
D002467:Cell Nucleus / Q000502:physiology; D002478:Cells, Cultured; D004247:DNA / Q000235:genetics; D017977:Deltaretrovirus; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008970:Molecular Weight; D011061:Poly A / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D011971:Receptors, Immunologic / Q000235:genetics*; D015375:Receptors, Interleukin-2; D013601:T-Lymphocytes / Q000382:microbiology / Q000502:physiology*; D014158:Transcription, Genetic
D012333:RNA, Messenger; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D011061:Poly A; D004247:DNA