Superoxide dismutase inhibits the superoxide-driven Fenton reaction at two different levels. Implications for a wider protective role.
Superoxide dismutase (SOD) completely inhibits the damage caused by a ferric-EDTA chelate in the presence of a superoxide-generating system. In this reaction superoxide is enzymically dismuted to hydrogen peroxide. Since hydrogen peroxide and a ferric-EDTA chelate are themselves a hydroxyl radical-generating system, it follows that SOD must also protect against damage done by this reaction. The ability of SOD to inhibit damage to deoxyribose caused by hydrogen peroxide and a ferric-EDTA chelate is experimentally demonstrated in this paper.
Gutteridge
J M
JM
D055598:Chemical Phenomena; D002621:Chemistry; D003855:Deoxyribose; D004492:Edetic Acid; D005290:Ferric Compounds; D005609:Free Radicals; D006861:Hydrogen Peroxide; D006878:Hydroxides; D017665:Hydroxyl Radical; D007501:Iron; D010084:Oxidation-Reduction; D013482:Superoxide Dismutase / Q000378:metabolism / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism*
D005290:Ferric Compounds; D005609:Free Radicals; D006878:Hydroxides; D013481:Superoxides; D017665:Hydroxyl Radical; D003855:Deoxyribose; D004492:Edetic Acid; D006861:Hydrogen Peroxide; D007501:Iron; D013482:Superoxide Dismutase; C019179:Fe(III)-EDTA