Cilofungin (LY121019) inhibits Candida albicans (1-3)-beta-D-glucan synthase activity.
Cilofungin (LY121019) inhibited Candida albicans growth and activity of (1-3)-beta-glucan synthase, for which it was a noncompetitive inhibitor with a Ki-app of 2.5 microM. Cilofungin had no effect on chitin synthase activity. Based on these and other data, it seems likely that cilofungin inhibits fungal growth by inhibiting (1-3)-beta-glucan synthase activity.
Taft
C S
CS
Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver 80262.
Stark
T
T
Selitrennikoff
C P
CP
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000201:enzymology*; D054714:Echinocandins; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors*; D008565:Membrane Proteins; D010455:Peptides / Q000494:pharmacology; D010456:Peptides, Cyclic; D029702:Schizosaccharomyces pombe Proteins
D000935:Antifungal Agents; D054714:Echinocandins; D008565:Membrane Proteins; D010455:Peptides; D010456:Peptides, Cyclic; D029702:Schizosaccharomyces pombe Proteins; C042101:cilofungin; D005964:Glucosyltransferases; C020570:1,3-beta-glucan synthase