title: The existence of low concentrations of atrial natriuretic peptide (ANP) in canine cerebrospinal fluid which does not correlate with plasma ANP levels.
abstract: Atrial natriuretic peptide (ANP) concentrations in the cerebrospinal fluid (CSF) and plasma of canine were 2.1 +/- 1.1 pg/ml (mean +/- S.D.) and 53.1 +/- 21.1 (n = 20), respectively. The regression coefficient between these concentrations was -0.0045 (P = n.s.). The ANP concentration in the CSF did not change even after the plasma ANP concentration was altered following the change of left atrial pressure, as in 4 cases of an experimental aortic regurgitation. Thus, ANP concentration in the CSF is not influenced by ANP concentrations in the plasma at least under our condition. Gel permeation chromatography revealed a single form of ANP in the position of authentic alpha-ANP in canine CSF, while a high molecular weight ANP peak was observed as well as alpha-ANP in the plasma.
authors.affiliation: Department of Emergency and Critical Care Medicine, Kitasato University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Masuda
authors.forename: K
authors.initials: K
authors.lastname: Ando
authors.forename: F
authors.initials: F
authors.lastname: Marumo
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics; D002850:Chromatography, Gel; D004285:Dogs; D005260:Female; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D012044:Regression Analysis
chemical_list: D009320:Atrial Natriuretic Factor