title: In vitro inhibition of human herpesvirus-6 by phosphonoformate.
abstract: HSB-2 cell cultures productively infected with human herpesvirus-6 were treated with the antiviral drugs phosphonoformic acid (PFA), acyclovir (ACV), and gancyclovir (DHPG). ACV and DHPG showed significant toxic effects on uninfected HSB-2 cells, yet only incompletely inhibited viral expression upon infection of the cells. PFA, however, showed little direct toxicity on HSB-2 cells while viral replication was inhibited significantly.
authors.affiliation: National Cancer Institute, Bethesda, Maryland 20892.
authors.forename: H Z
authors.initials: HZ
authors.lastname: Streicher
authors.forename: C L
authors.initials: CL
authors.lastname: Hung
authors.forename: D V
authors.initials: DV
authors.lastname: Ablashi
authors.forename: K
authors.initials: K
authors.lastname: Hellman
authors.forename: C
authors.initials: C
authors.lastname: Saxinger
authors.forename: J
authors.initials: J
authors.lastname: Fullen
authors.forename: S Z
authors.initials: SZ
authors.lastname: Salahuddin
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D017245:Foscarnet; D015774:Ganciclovir; D006564:Herpesviridae / Q000187:drug effects*; D006801:Humans; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D009943:Organophosphorus Compounds; D017245:Foscarnet; D010746:Phosphonoacetic Acid; D015774:Ganciclovir; D000212:Acyclovir