Identification of new gene products coded from X regions of human T-cell leukemia viruses.
Antibodies were raised against oligopeptides deduced from the nucleotide sequence in the conserved region located between env and the 3' long terminal repeat in human T-cell leukemia virus type I (HTLV-I) and type II (HTLV-II) to detect a protein coded from this region in virus-infected cells. Two of these antibodies precipitated a protein of 41 kilo-daltons in HTLV-I-infected cell lines and a protein of 38 kilo-daltons in HTLV-II-infected cells. The protein in HTLV-I-infected cells was precipitated by plasma from patients with adult T-cell leukemia but not by plasma from a normal adult. These results indicate that these proteins were translated from new coding regions (X) present in HTLV-I and HTLV-II.
Shimotohno
K
K
Miwa
M
M
Slamon
D J
DJ
Chen
I S
IS
Hoshino
H
H
Takano
M
M
Fujino
M
M
Sugimura
T
T
D001483:Base Sequence; D002460:Cell Line; D004279:DNA, Viral / Q000032:analysis*; D017977:Deltaretrovirus / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007163:Immunosorbent Techniques; D007938:Leukemia / Q000235:genetics; D008970:Molecular Weight; D009842:Oligopeptides / Q000276:immunology; D013601:T-Lymphocytes; D014764:Viral Proteins / Q000032:analysis*
D004279:DNA, Viral; D009842:Oligopeptides; D014764:Viral Proteins