title: [Plasma ANP levels and its relation to electrolyte and water regulation in neurosurgical intensive care patients].
abstract: We examined the relation between plasma atrial natriuretic peptide (ANP) and the changes of the regulating hormones ADH and renin aldosterone in 20 neurosurgical intensive care patients. All patients suffered from elevated intracranial pressure due to severe head trauma or severe subarachnoidal hemorrhage of the anterior circulation. Under controlled mechanical hyperventilation (CMV) with PEEP, 15 patients without evidence of central dysregulation showed no change in plasma ANP, ADH and aldosterone. In five patients with severe central dysregulation of either electrolytes or blood pressure, increases of plasma ANP of various degrees could be observed together with a decline in serum aldosterone.
authors.affiliation: Neurochirurgische Klinik, Universität Düsseldorf.
authors.forename: J C
authors.initials: JC
authors.lastname: Kiwit
authors.forename: C
authors.initials: C
authors.lastname: Schröders
authors.forename: G
authors.initials: G
authors.lastname: Wambach
mesh_terms: D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001927:Brain Diseases / Q000601:surgery*; D006259:Craniocerebral Trauma / Q000503:physiopathology; D003422:Critical Care; D006801:Humans; D007427:Intracranial Pressure; D012016:Reference Values; D012083:Renin / Q000097:blood; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology; D014667:Vasopressins / Q000097:blood; D014882:Water-Electrolyte Balance
chemical_list: D014667:Vasopressins; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin
vernacular_title: Untersuchung des Plasma-ANP-Spiegels und seiner Beziehung zum Elektrolyt- und Wasserhaushalt bei neurochirurgischen Intensivpatienten.