Albuminuria following nephroangiography with low osmolar contrast media in the rat.
The degree of albuminuria after selective nephroangiography was investigated in anaesthetized rats. Iopentol, iopromide, iodixanol and compound 2-5410-4A all caused a slight but not statistically significant increase in albuminuria when compared with the control group. After ioxaglate injection a high degree of albuminuria was observed which was statistically significant (p less than 0.05) compared with all other contrast media and control groups.
Holtz
E
E
Department of Pharmacology and Toxicology, Nycomed AS, Oslo, Norway.
Heglund
I F
IF
Golman
K
K
D000419:Albuminuria / Q000139:chemically induced*; D000792:Angiography; D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D007472:Iohexol / Q000009:adverse effects / Q000031:analogs & derivatives; D007485:Ioxaglic Acid / Q000009:adverse effects; D007668:Kidney / Q000098:blood supply*; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D014283:Triiodobenzoic Acids / Q000009:adverse effects
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C038192:iopromide; C053571:iopentol; C073725:compound 2-5410-4A; C044834:iodixanol; D007485:Ioxaglic Acid