title: Familial adult T-cell leukemia.
abstract: Two siblings who developed adult T-cell leukemia (ATL) are presented. The patient and 7 of 26 healthy family members examined had the serum antibodies against ATL-associated antigens (ATLA). This family study shows that two main routes of transmission of human T-cell leukemia virus (HTLV) may be involved: one is the route from parents to children and the other is horizontal transmission among spouses, especially from husband to wife; the anti-ATLA-positive family is considered to be a high-risk group for ATL.
authors.forename: Y
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Nishimura
authors.forename: K
authors.initials: K
authors.lastname: Takatsuki
authors.forename: T
authors.initials: T
authors.lastname: Motoori
authors.forename: M
authors.initials: M
authors.lastname: Morimatsu
authors.forename: T
authors.initials: T
authors.lastname: Yasaka
authors.forename: I
authors.initials: I
authors.lastname: Ohya
authors.forename: T
authors.initials: T
authors.lastname: Koga
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology; D017977:Deltaretrovirus / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D010375:Pedigree; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D000914:Antibodies, Viral