title: Relation between tissue nature and (18F) fluorodeoxyglucose kinetics evaluated by dynamic positron emission tomography in human brain tumors.
abstract: Using dynamic positron emission tomographic (PET) scans, kinetic rate constants in the (18F) fluorodeoxyglucose (18FDG) model and glucose consumption rate were measured in human brain tumors. In the tumor tissue, all rate constants were higher on the average in the glioma grade IV and the non-glial tumor groups. The k*3 showed wide deviation in the glioma grade IV group. Discrepancy was found between the k*3 and the glucose consumption rate in several cases. The k*1 correlated with the neovascularity in tumors confirmed at angiography. Analysis of the rate constants might be useful for interpreting tumor nature and predicting its malignancy.
authors.affiliation: Department of Radiology and Nuclear Medicine, School of Medicine, Akita University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Ogawa
authors.forename: K
authors.initials: K
authors.lastname: Mineura
authors.forename: K
authors.initials: K
authors.lastname: Uemura
authors.forename: I
authors.initials: I
authors.lastname: Kanno
authors.forename: F
authors.initials: F
authors.lastname: Shishido
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: A
authors.initials: A
authors.lastname: Inugami
authors.forename: S
authors.initials: S
authors.lastname: Higano
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D019788:Fluorodeoxyglucose F18; D005910:Glioma / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D014055:Tomography, Emission-Computed
chemical_list: D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose