title: Identification of transformation-specific proteins synthesized in cryptovirogenic mammalian cells.
abstract: The cryptovirogenic PR-RSH-19 (H-19) hamster cell line, derived originally from a tumour induced by the virus rescued from XC cells by transfection, was studied. The pp60v-src protein was detected by immunoprecipitation with sera from tumour-bearing rabbits (TBR sera) from lysates of H-19 cells. A closely related protein p60 was precipitated by antiserum obtained from hamsters with tumours induced by H-19 cells. The pp60v-src of H-19 cells possesses an associated kinase activity. These results are consistent with the notion that the detected pp60v-src protein is a product of the cryptic sequences in H-19 cells.
authors.forename: M
authors.initials: M
authors.lastname: Grófová
authors.forename: J
authors.initials: J
authors.lastname: Bízik
authors.forename: S
authors.initials: S
authors.lastname: Blahová
authors.forename: J
authors.initials: J
authors.lastname: Geryk
authors.forename: J
authors.initials: J
authors.lastname: Svoboda
mesh_terms: D000818:Animals; D000912:Antibodies, Neoplasm / Q000276:immunology; D001358:Avian Sarcoma Viruses; D002460:Cell Line; D002472:Cell Transformation, Viral; D002642:Chick Embryo; D006224:Cricetinae; D008647:Mesocricetus; D009363:Neoplasm Proteins / Q000276:immunology / Q000302:isolation & purification*; D015688:Oncogene Protein pp60(v-src); D011494:Protein Kinases / Q000302:isolation & purification; D011817:Rabbits; D012513:Sarcoma, Experimental / Q000032:analysis* / Q000382:microbiology; D014764:Viral Proteins / Q000276:immunology / Q000302:isolation & purification*
chemical_list: D000912:Antibodies, Neoplasm; D009363:Neoplasm Proteins; D014764:Viral Proteins; D011494:Protein Kinases; D015688:Oncogene Protein pp60(v-src)