title: Oocyte maturation as regulated by follicular factors.
abstract: Follicular fluid (FFl), obtained from 24 women treated with clomiphene/hCG in an in vitro fertilization program, was characterized with respect to steroid hormone levels and oocyte maturation inhibitor (OMI) activity. Three FFl samples apparently were derived from cystic follicles and contained low steroid levels and no OMI activity in an in vitro rat oocyte assay. The remaining 21 follicles contained normal preovulatory steroid levels and mature and generally fertilizable oocytes. In 7 of these follicles the FFl (at 50% concentration) significantly inhibited rat oocyte meiosis, while 14 exerted no OMI activity. The results confirm earlier work on porcine and human FFl, suggesting that the putative OMI activity declines with follicular maturation.
authors.forename: T
authors.initials: T
authors.lastname: Hillensjö
authors.forename: M
authors.initials: M
authors.lastname: Brännström
authors.forename: S
authors.initials: S
authors.lastname: Chari
authors.forename: E
authors.initials: E
authors.lastname: Daume
authors.forename: C
authors.initials: C
authors.lastname: Magnusson
authors.forename: L
authors.initials: L
authors.lastname: Nilsson
authors.forename: A
authors.initials: A
authors.lastname: Sjögren
authors.forename: J
authors.initials: J
authors.lastname: Törnell
mesh_terms: D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D002996:Clomiphene / Q000627:therapeutic use; D004958:Estradiol / Q000032:analysis; D005260:Female; D005307:Fertilization in Vitro; D006064:Gonadotropins, Equine / Q000494:pharmacology; D006801:Humans; D009865:Oocytes / Q000187:drug effects / Q000502:physiology*; D006080:Ovarian Follicle / Q000502:physiology*; D011374:Progesterone / Q000032:analysis; D011388:Prolactin / Q000032:analysis; D051381:Rats; D013739:Testosterone / Q000032:analysis
chemical_list: D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine; D002996:Clomiphene; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D003994:Bucladesine; D011388:Prolactin