title: Basal cell carcinoma and breast carcinoma following repeated fluoroscopic examinations of the chest.
abstract: A 69-year-old white Italian woman was first seen at Memorial Sloan-Kettering Cancer Center in 1981 concerning several skin growths on her back. The patient had had several basal cell carcinomas surgically removed from her back during the preceding 5 years. There was no history of arsenic ingestion or prolonged sun exposure and her family history was negative for skin cancer. The patient had developed pulmonary tuberculosis in 1938 and was treated with pneumothorax therapy. She had had more than 50 fluoroscopic examinations of the chest following this therapy, as well as multiple diagnostic x-ray films since that time. She recalled that she had faced the fluoroscopy beam during the procedure. In 1959, she had a transabdominal hysterectomy for fibroid tumors. In 1980 she underwent a right modified radical mastectomy for adenoid cystic carcinoma of the breast; biopsies of lymph nodes were negative. Physical examination revealed a thin, white woman with a right mastectomy scar. On the back, clustered in the interscapular region, were multiple scars and nine erythematous nodules with pearly borders, telangiectasia, and translucent surfaces. Within several nodules there were areas of light and dark brown pigmentation. There were no other suspicious lesions on the head, chest, or extremities, nor did the patient show any evidence of the basal cell nevus syndrome. Biopsy of all lesions revealed basal cell carcinoma, some of which were pigmented, without evidence of chronic radiodermatitis. All lesions were treated with curettage and electrodesiccation three times with good cosmetic results (Fig. 1).
authors.forename: P L
authors.initials: PL
authors.lastname: Myskowski
authors.forename: E
authors.initials: E
authors.lastname: Gumpertz
authors.forename: B
authors.initials: B
authors.lastname: Safai
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology*; D003528:Carcinoma, Adenoid Cystic / Q000209:etiology; D002280:Basal Cell Carcinoma / Q000209:etiology; D005260:Female; D005471:Fluoroscopy / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D013902:Radiography, Thoracic / Q000009:adverse effects*; D012878:Skin Neoplasms / Q000209:etiology*