Protective effects of "cerebroactive drugs" in a model of acute hypoxia.
A systematic study of the hypobaric hypoxia method was carried out, using a wide range of vasodilators and metabolic modifiers. In general cerebral metabolic modifiers have a more effective antihypoxic action than cerebral vasodilators. After a discussion, the conclusion is that hypobaric hypoxia is useful as an initial screening procedure.
Grau
M
M
Balasch
J
J
D000818:Animals; D001274:Atmospheric Pressure; D001921:Brain / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004195:Disease Models, Animal; D000860:Hypoxia / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D007556:Isoxsuprine / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013468:Suloctidil / Q000494:pharmacology; D013696:Temperature; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; D007556:Isoxsuprine; D013468:Suloctidil