Phorbol ester-induced expression and function of the interleukin 2 receptor in human B lymphocytes.
The expression of the interleukin 2 receptor (Tac) on normal B cells and Epstein-Barr virus-transformed lymphoblastoid B cell lines is induced by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The receptor on B cells is indistinguishable from that on T cells by serological and biochemical analysis. It is functionally active so that TPA-induced B cells respond to interleukin 2 by increased DNA synthesis. These results suggest that the expression of Tac is not exclusively restricted to T cells and that interleukin 2 may play a role in B cell differentiation.
Ando
I
I
Crawford
D H
DH
Kissonerghis
M A
MA
Owen
M J
MJ
Beverley
P C
PC
D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002460:Cell Line; D002472:Cell Transformation, Viral; D004854:Herpesvirus 4, Human; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology; D010704:Phorbols / Q000494:pharmacology*; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000187:drug effects*; D015375:Receptors, Interleukin-2; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D007376:Interleukin-2; D010704:Phorbols; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D013755:Tetradecanoylphorbol Acetate