A metabolite of riboflavin binds to the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) receptor.
A cytosolic receptor to which TCDD binds with high affinity has been reported in a number of rodent tissues, but the endogenous/natural ligand is not known. However, lumichrome, a metabolite of riboflavin, competed with 3H-TCDD for binding to the cytosolic receptor. Neither riboflavin nor riboflavin-5-phosphate competed for binding to the TCDD receptor in rat liver cytosol. Lumichrome is the first known endogenous chemical in the rat to exhibit affinity for the TCDD receptor.
Kurl
R N
RN
Villee
C A
CA
D000818:Animals; D002499:Centrifugation, Density Gradient; D003600:Cytosol / Q000378:metabolism; D004147:Dioxins / Q000378:metabolism*; D005415:Flavins / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D000072317:Polychlorinated Dibenzodioxins / Q000378:metabolism*; D051381:Rats; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug / Q000378:metabolism*; D012256:Riboflavin / Q000378:metabolism*
D004147:Dioxins; D005415:Flavins; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug; C001559:7,8-dimethylalloxazine; D012256:Riboflavin