title: Usefulness of 99mTc pyrophosphate bone scintigraphy in the survey of dialysis osteodystrophy.
abstract: Fogelman's score (FS) was used to determine the usefulness of 99mTc pyrophosphate (Tc-PP) bone scintigraphy in the evaluation of dialysis osteodystrophy. FS correlated well with bone 47Ca accretion rate. It remained stable after six months in patients treated with 1 alpha (OH)D3 and increased significantly in a randomised group of untreated patients. It decreased after two years of 1 alpha (OH)D3 therapy while serum calcium increased and iPTH and alkaline phosphatases decreased. Patients with low FS, treated by 1 alpha (OH)D3, rapidly developed hypercalcaemia. In cases of spontaneous hypercalcaemia, parathyroidectomy did not normalise serum calcium in patients with low FS despite a significant decrease in serum iPTH. Lower FS were associated with a higher increase in serum aluminium after desferrioxamine (DFO) administration and in two cases of proven aluminium osteomalacia, DFO therapy was followed by a dramatic increase in FS.
authors.forename: J L
authors.initials: JL
authors.lastname: Vanherweghem
authors.forename: A
authors.initials: A
authors.lastname: Schoutens
authors.forename: P
authors.initials: P
authors.lastname: Bergman
authors.forename: M
authors.initials: M
authors.lastname: Dhaene
authors.forename: M
authors.initials: M
authors.lastname: Goldman
authors.forename: M
authors.initials: M
authors.lastname: Fuss
authors.forename: P
authors.initials: P
authors.lastname: Kinnaert
mesh_terms: D001842:Bone and Bones / Q000000981:diagnostic imaging; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000000981:diagnostic imaging* / Q000209:etiology; D011756:Diphosphates; D006801:Humans; D011877:Radionuclide Imaging; D006435:Renal Dialysis / Q000009:adverse effects*; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate
chemical_list: D011756:Diphosphates; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium