title: Medium isotope effect in [3H]diazepam binding to benzodiazepine receptors of synaptic membranes.
abstract: Replacement of H2O by D2O resulted in significantly higher amount of [3H]diazepam specifically bound to synaptic membranes. The isotope effect arises from increased number of binding sites in D2O and is associated with a stronger solvation of membrane receptors by heavy water.
authors.forename: J
authors.initials: J
authors.lastname: Kardos
authors.forename: I
authors.initials: I
authors.lastname: Kovács
authors.forename: M
authors.initials: M
authors.lastname: Simonyi
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002417:Cattle; D003903:Deuterium / Q000378:metabolism*; D003975:Diazepam / Q000378:metabolism*; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism*
chemical_list: D011963:Receptors, GABA-A; D003903:Deuterium; D003975:Diazepam