Mechanism of diuretic-induced hypopotassemia in human hypertension.
Diuretic treatment (hydrochlorothiazide) induced a marked decrease of red cell membrane Na+K+ ATPase activity in excessive potassium loser hypertensive patients. The decreased activity occurred within 2-4 weeks of treatment and returned to baseline in 4-6 weeks after cessation of treatment. Simultaneously, red cell sodium increased, potassium decreased together with increased 24-h urinary excretion. The persistent low serum potassium may be due to impaired absorption of potassium from the gut as a result of suppressed enzyme activity since total body potassium appears also to decrease. The decreased Na+K+ ATPase activity may be due to a direct effect of the diuretic on cell membrane.
Kezdi
P
P
Danopulos
D
D
Stanley
E L
EL
Mullins
M
M
D002118:Calcium / Q000097:blood / Q000652:urine; D004910:Erythrocyte Membrane / Q000201:enzymology; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects* / Q000627:therapeutic use; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D007008:Hypokalemia / Q000139:chemically induced*; D008274:Magnesium / Q000097:blood / Q000652:urine; D011188:Potassium / Q000097:blood / Q000652:urine; D011446:Prospective Studies; D012964:Sodium / Q000097:blood / Q000652:urine; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood
D006852:Hydrochlorothiazide; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D008274:Magnesium; D011188:Potassium; D002118:Calcium