Synthesis and study of spin-labeled nitrosoureas.
For the first time we have synthesized spin-labeled nitrosoureas and have studied their properties--reduction of the iminoxyl group by vitamin C leading to the formation of the corresponding hydroxylamine derivatives and degradation in the presence of an aminoradical, leading to biradicals. The ESR spectra of biradicals in methanol have nine hyperfine resonance lines. The spin-labeled nitrosoureas have shown a high antitumor activity against the L 1210 lymphoid leukemia and P 388 lymphocytic leukemia in BDF1 mice. A study of a broad range of transplantable tumors is in progress.
Raikov
Z
Z
Todorov
D
D
Ilarionova
M
M
Demirov
G
G
Tsanova
T
T
Kafalieva
D
D
D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D009607:Nitrosourea Compounds / Q000138:chemical synthesis*; D013113:Spin Labels / Q000138:chemical synthesis*
D009607:Nitrosourea Compounds; D013113:Spin Labels