Cerebral glucose metabolic change after high-dose methotrexate treatment in patients with acute lymphocytic leukemia.
An investigation was carried out to study the changes in the cerebral metabolic rate for glucose (CMRGlc) after high-dose methotrexate infusion (HD-MTX) in leukemic children, compared with the rate before such treatment. This is the first report on the relation between HD-MTX and the CMRGlc. An infusion of HD-MTX significantly reduced the glucose metabolism. It is suggested that this depression of the CMRGlc may have been associated with acute neurotoxicity of MTX. Measurement of the CMRGlc may be of value in detecting neurotoxicity of MTX. The reasons for these metabolic alterations need further investigation.
Shishido
F
F
Department of Radiology, Research Institute for Brain and Blood Vessels-Akita, Japan.
Uemura
K
K
Komatsu
K
K
Inugami
A
A
Ogawa
T
T
Yamaguchi
T
T
Murakami
M
M
Kanno
I
I
D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism; D014055:Tomography, Emission-Computed
D005947:Glucose; D008727:Methotrexate