Phytohemagglutinin activation of the transcription of the bovine leukemia virus genome requires de novo protein synthesis.
Addition of supramitogenic doses of phytohemagglutinin (PHA) to short-term cultures of neoplastic or nonneoplastic lymphocytes infected with bovine leukemia virus increased the synthesis of the major core virion antigen (p25) by 5- to 10-fold. Such stimulation was not due to the mitogenic effect of PHA or to a generalized increase in cellular RNA or protein synthesis but rather to enhanced transcription of the viral genome by a PHA-induced protein.
Chatterjee
R
R
Gupta
P
P
Kashmiri
S V
SV
Ferrer
J F
JF
D001483:Base Sequence; D005814:Genes, Viral; D001909:Leukemia Virus, Bovine / Q000235:genetics*; D010835:Phytohemagglutinins / Q000494:pharmacology*; D012190:Retroviridae / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects*; D014764:Viral Proteins / Q000096:biosynthesis*
D010835:Phytohemagglutinins; D014764:Viral Proteins