[Comparative pharmacological characteristics of peptides of the atrial natriuretic factor family].
Comparative antihypertensive and natriuretic activities of atrial natriuretic factor (ANF) and its nearest shortened analogues--atriopeptines (AP) were studied in vivo on narcotized rats; and their peripheral vasodilating activities were studied in vitro on isolated rings of rat's thoracic aorta. The results obtained in vivo allow a following series of comparative antihypertensive and vasodilating activity: alpha rANF greater than APII greater than AP7-27. alpha rANF, APIII and APII did not differ significantly in vasodilating activity on isolated vessels; analogue 7-27 was less active. Thus further search of highly active shortened atriopeptin analogues is necessary for developing new drugs on their basis.
Bespalova
Zh D
ZhD
Vinogradov
V A
VA
Zhukovskiĭ
S V
SV
Kaĭkov
M I
MI
Korobov
N V
NV
D000818:Animals; D000959:Antihypertensive Agents; D001012:Aorta, Abdominal / Q000187:drug effects; D009320:Atrial Natriuretic Factor / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014665:Vasodilator Agents
D000959:Antihypertensive Agents; D014665:Vasodilator Agents; D009320:Atrial Natriuretic Factor
Sravnitel'naia farmakologicheskaia kharakteristika peptidov semeĭstva atrial'nogo natriĭureticheskogo faktora.