The hydrolysis of ATP that accompanies actin polymerization is essentially irreversible.
The hydrolysis of ATP that accompanies the polymerization of actin occurs on the F-actin subsequent to the addition of the G-ATP-actin subunit to the elongating filament. We now show that this ATP hydrolysis is essentially irreversible. Thus, a large decrease in free energy occurs at the cleavage step, F-ATP-actin----F-ADP-Pi-actin.
Carlier
M F
MF
Laboratoire d'Enzymologie, CNRS, Gif-sur-Yvette, France.
Pantaloni
D
D
Evans
J A
JA
Lambooy
P K
PK
Korn
E D
ED
Webb
M R
MR
D000199:Actins / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D006868:Hydrolysis; D010710:Phosphates / Q000378:metabolism; D011108:Polymers; D011817:Rabbits
D000199:Actins; D010710:Phosphates; D011108:Polymers; D000255:Adenosine Triphosphate; D000252:Calcium-Transporting ATPases