Antagonists of the antidiuretic activity of vasopressin.
Competitive antagonists of the antidiuretic (ADH) activity of vasopressin were first described some six years ago. When studied in vitro, ADH antagonists displace vasopressin from specific renal binding sites and antagonize, in a competitive fashion, vasopressin stimulation of adenylate cyclase and transepithelial water, salt, and urea fluxes. When studied in vivo, the ADH antagonists increase renal water excretion and antagonize, in a competitive fashion, the ADH activity of vasopressin. Marked species heterogeneity is apparent with ADH antagonists in vivo, and inconsistencies between in vitro and in vivo findings within the same species are reported. Other renal responses associated with administration of ADH antagonists include changes in renal hemodynamics and renal salt and urea excretion. The effects on salt excretion appear to be limited to those species in which vasopressin stimulation of epithelial salt reabsorption has been demonstrated. In summary, the role of vasopressin as the principal factor regulating renal water handling is supported by experience with ADH receptor antagonists. However, that experience also indicates the emerging significance of autocoids, and other synergistic factors, to affect ADH receptor/effector mechanisms and to modulate renal ADH responses.
Kinter
L B
LB
Department of Pharmacology, Smith Kline & French Laboratories, Swedeland, Pennsylvania 19479.
Huffman
W F
WF
Stassen
F L
FL
D000818:Animals; D001929:Brain Edema / Q000503:physiopathology; D004231:Diuresis / Q000187:drug effects*; D004573:Electrolytes / Q000652:urine; D006439:Hemodynamics; D006801:Humans; D007668:Kidney / Q000098:blood supply; D011945:Receptors, Angiotensin / Q000378:metabolism; D017483:Receptors, Vasopressin; D013329:Structure-Activity Relationship; D014508:Urea / Q000652:urine; D014667:Vasopressins / Q000037:antagonists & inhibitors*
D004573:Electrolytes; D011945:Receptors, Angiotensin; D017483:Receptors, Vasopressin; D014667:Vasopressins; D014508:Urea