title: Allelism in the HLA class I multigene family.
abstract: Recent data on the structure of functional HLA class I genes shows that, at least at the HLA-A locus, the allelic genes are more related to each other than to HLA genes from other loci. This "A-ness" is discernible at the protein sequence level but much more evident when nucleotide sequences are compared; the homology is particularly striking in the 3' non-coding region. Genes coding for the same HLA specificity in different genetic backgrounds show no obvious difference, although in one case the 3' flanking regions are clearly different; the restriction maps around the HLA-A3 and HLA-AW24 genes are also compared to see whether the chromosomal environments of these two genes are recognizably similar.
authors.forename: R
authors.initials: R
authors.lastname: Sodoyer
authors.forename: C
authors.initials: C
authors.lastname: Nguyen
authors.forename: T
authors.initials: T
authors.lastname: Strachan
authors.forename: M J
authors.initials: MJ
authors.lastname: Santoni
authors.forename: M
authors.initials: M
authors.lastname: Damotte
authors.forename: J
authors.initials: J
authors.lastname: Trucy
authors.forename: B R
authors.initials: BR
authors.lastname: Jordan
mesh_terms: D000483:Alleles; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis; D004262:DNA Restriction Enzymes / Q000378:metabolism; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens; D006801:Humans; D051379:Mice
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D004247:DNA; D004262:DNA Restriction Enzymes