title: [Antibiotic therapy protocol using ceftazidime 3g/day alone or in combination with vancomycin or amikacin. In febrile episodes in neutropenic patients].
abstract: In a preliminary study of 21 febrile episodes in neutropenic patients ceftazidime used as empirical treatment in doses of 3 grams per day succeeded in controlling fever in 74 per cent of the cases. Laboratory studies performed in patients with Gram-negative septicaemia showed clinically effective plasma concentrations of the antibiotic. A trial of ceftazidime (3 g/day) administered alone or combined with amikacin or vancomycin is currently in progress in two medical centres. No statistically significant conclusions could be reached from an intermediate study.
authors.affiliation: Service d'Hématologie, Institut Gustave Roussy, Villejuif.
authors.forename: J P
authors.initials: JP
authors.lastname: Marie
authors.forename: J L
authors.initials: JL
authors.lastname: Pico
authors.forename: D
authors.initials: D
authors.lastname: Chiche
authors.forename: F
authors.initials: F
authors.lastname: Fitoussi
authors.forename: A
authors.initials: A
authors.lastname: Delmer
authors.forename: D
authors.initials: D
authors.lastname: Baume
authors.forename: B
authors.initials: B
authors.lastname: Rio
authors.forename: F
authors.initials: F
authors.lastname: Ajchenbaum
authors.forename: H
authors.initials: H
authors.lastname: Richet
authors.forename: C
authors.initials: C
authors.lastname: Tancrède
mesh_terms: D000380:Agranulocytosis / Q000150:complications*; D000583:Amikacin / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D002442:Ceftazidime / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D009503:Neutropenia / Q000150:complications*; D011897:Random Allocation; D014640:Vancomycin / Q000627:therapeutic use*
chemical_list: D014640:Vancomycin; D000583:Amikacin; D002442:Ceftazidime
vernacular_title: Protocole d'antibiothérapie utilisant la ceftazidime à la dose de 3 g/jour seule ou en association avec la vancomycine ou l'amikacine. Lors des épisodes fébriles chez le neutropénique.