A 25 000 dalton inhibitor of cAMP independent protein kinases present in rat liver HMG protein preparations.
A protein kinase inhibitor was found in rat liver cells as a component of HMG proteins. It is located in cytosol as well as in nuclei. It inhibits all tested cAMP independent protein kinases and has no effect on cAMP dependent protein kinases. This inhibitor is a 25 000 Da protein. It has no ATPase, phosphoprotein phosphatase or proteinase activity and is heat unstable.
Levy-Favatier
F
F
Delpech
M
M
Riffe
A
A
Kruh
J
J
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology; D003600:Cytosol / Q000201:enzymology; D006609:High Mobility Group Proteins / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008970:Molecular Weight; D010447:Peptide Hydrolases / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D047428:Protein Kinase Inhibitors; D051381:Rats; D011919:Rats, Inbred Strains
D006609:High Mobility Group Proteins; D047428:Protein Kinase Inhibitors; D010749:Phosphoprotein Phosphatases; D010447:Peptide Hydrolases; D000251:Adenosine Triphosphatases