[Morphology and histogenesis problems in cervical cancer].
Both most common and rare varieties of uterine cervix carcinoma were studied light and electron microscopically. It is shown that tumours histologically classified as squamous-cell carcinoma originate either from the squamous epithelium of the ectocervix or from the metaplastic epithelium. Characteristic ultrastructural features of these histogenetic variants of squamous-cell carcinoma are described. The authors' and literature data are presented indicating that the great histological variety of adenocarcinomas and glandular-squamous carcinomas is due to the pluripotential properties of proliferating stem cells capable of forming glandular, solid and squamous-cell structures. The source of clear-cell adenocarcinoma may be not only Gartner's duct but the mullerian epithelium as well. The classification of uterine cervix carcinomas reflecting their histogenesis is proposed.
Iakovleva
I A
IA
Chernyĭ
A P
AP
D000230:Adenocarcinoma / Q000209:etiology / Q000473:pathology; D000328:Adult; D000368:Aged; D001706:Biopsy; D003528:Carcinoma, Adenoid Cystic / Q000209:etiology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology; D002584:Cervix Uteri / Q000473:pathology; D004848:Epithelium / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008649:Mesonephroma / Q000209:etiology / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D009024:Morphogenesis; D002583:Uterine Cervical Neoplasms / Q000145:classification / Q000209:etiology / Q000473:pathology*
Morfologiia i voprosy gistogeneza raka sheĭki matki.