title: Parathyroid adenomas evaluated by Tl-201/Tc-99m pertechnetate subtraction scintigraphy and high-resolution ultrasonography.
abstract: Thallium-201/technetium-99m pertechnetate subtraction scintigraphy of the parathyroid glands was performed in a prospective study of 33 patients who had undergone bilateral neck exploration for elevated serum calcium and serum parathyroid hormone levels. In 31 cases, the Tl-201/Tc-99m subtraction technique yielded an overall sensitivity of 81%, specificity of 99%, and accuracy of 94% for identifying solitary parathyroid adenomas. Tl-201/Tc-99m subtraction scintigraphy correctly identified 73% of parathyroid adenomas weighing less than 499 mg, 79% of those weighing 500-1,499 mg, and 100% of adenomas weighing more than 1,500 mg. In a subgroup of 24 patients with solitary parathyroid adenomas who underwent both scintigraphy and high-resolution sonography, the sensitivity, specificity, and accuracy of both procedures were similar.
authors.forename: G G
authors.initials: GG
authors.lastname: Winzelberg
authors.forename: J D
authors.initials: JD
authors.lastname: Hydovitz
authors.forename: K R
authors.initials: KR
authors.lastname: O'Hara
authors.forename: K M
authors.initials: KM
authors.lastname: Anderson
authors.forename: E
authors.initials: E
authors.lastname: Turbiner
authors.forename: T S
authors.initials: TS
authors.lastname: Danowski
authors.forename: R D
authors.initials: RD
authors.lastname: Lippe
authors.forename: G A
authors.initials: GA
authors.lastname: Melada
authors.forename: A M
authors.initials: AM
authors.lastname: Harrison
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D010282:Parathyroid Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D013382:Subtraction Technique; D013793:Thallium; D014463:Ultrasonography
chemical_list: D011868:Radioisotopes; D013670:Sodium Pertechnetate Tc 99m; D013793:Thallium