title: Deficiency of the autologous mixed lymphocyte reactions of non-T/T and T/T type in intravenous drug abusers infected by the human immunodeficiency virus (HIV).
abstract: In the present study both responsiveness and stimulatory capacity in autologous mixed lymphocyte reactions (AMLRs) of non-T/T and T/T type, as well as in allogeneic mixed lymphocyte reaction (MLR), were evaluated in 30 intravenous drug abusers (IDAs) infected by the human immunodeficiency virus (HIV) and in 10 HIV-negative IDAs. The production of interleukin 2 (IL2), and the expression of HLA Class II antigens and IL2 receptors by PHA-activated T lymphocytes were also evaluated. A severe impairment of both responsiveness and stimulatory capacity in MLR and AMLRs was found in the HIV-positive IDAs and not in the HIV-negative IDAs. The HIV-positive IDAs showed also a defective expression of HLA Class II antigens, whereas the IL2 production and the IL2 receptor expression were in the normal range. The present data are consistent with similar observations in male homosexuals with AIDS-related complex and confirm that the HIV infection induces a broad spectrum of immunological abnormalities leading to a progressive derangement of the immunocompetence.
authors.affiliation: Cattedra di Patologia Medica RR, ISMI, University of Genova, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Puppo
authors.forename: I
authors.initials: I
authors.lastname: Pierri
authors.forename: S
authors.initials: S
authors.lastname: Rogna
authors.forename: R
authors.initials: R
authors.lastname: Pattarini
authors.forename: P L
authors.initials: PL
authors.lastname: Piovano
authors.forename: S
authors.initials: S
authors.lastname: Catellani
authors.forename: O E
authors.initials: OE
authors.lastname: Varnier
authors.forename: F
authors.initials: F
authors.lastname: Indiveri
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology*; D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies; D006679:HIV Seropositivity; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis / Q000378:metabolism; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D011971:Receptors, Immunologic / Q000096:biosynthesis; D015375:Receptors, Interleukin-2; D019966:Substance-Related Disorders / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D015483:HIV Antibodies; D007376:Interleukin-2; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2