title: c-fms expression is a molecular marker of human acute myeloid leukemias.
abstract: The c-fms protooncogene product was identified as the CSF-1 or M-CSF receptor, a polypeptide growth factor that plays a major role in myelomonocytic differentiation. This led us to look for expression of c-fms in fresh acute myeloid leukemia (AML) cells, using Northern blot analysis. c-fms expression was found in the leukemic cells of 28 AML patients, regardless of their stage of differentiation, which was assessed in the French-American-British (FAB) classification. However, the level of c-fms expression was especially high in AML of the M5 stage. High levels of expression were not accompanied by either amplification or rearrangements of the c-fms gene in AML cell DNAs. In contrast, c-fms expression was not found in acute lymphoid leukemias, whether of T or B origin. Thus, c-fms expression appears as a specific molecular marker of leukemogenesis in the myeloid lineage.
authors.affiliation: INSERM, Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Dubreuil
authors.forename: H
authors.initials: H
authors.lastname: Torrès
authors.forename: M A
authors.initials: MA
authors.lastname: Courcoul
authors.forename: F
authors.initials: F
authors.lastname: Birg
authors.forename: P
authors.initials: P
authors.lastname: Mannoni
mesh_terms: D014408:Biomarkers, Tumor / Q000302:isolation & purification*; D002455:Cell Division; D002460:Cell Line; D005786:Gene Expression Regulation; D006412:Hematopoietic Stem Cells / Q000032:analysis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D011519:Proto-Oncogenes; D016186:Receptor, Macrophage Colony-Stimulating Factor
chemical_list: D014408:Biomarkers, Tumor; D011518:Proto-Oncogene Proteins; D016186:Receptor, Macrophage Colony-Stimulating Factor