title: Effective dose range of enalapril in mild to moderate essential hypertension.
abstract: The dose-response relationship of enalapril was evaluated in a double-blind, balanced, two-period, incomplete-block study in 91 patients with mild to moderate essential hypertension. Patients were randomly assigned to two of six treatments: placebo, 2.5, 5, 10, 20 and 40 mg/day of enalapril maleate. There were two 3-week treatment periods, each preceded by a 4-week, single-blind placebo washout. Each dose of enalapril produced significant decreases in standing and supine systolic and diastolic blood pressure after 2 and 3 weeks of treatment. There were no significant changes on placebo. There was a significant linear dose response relationship for both mean blood pressure and mean change from baseline in blood pressure (P less than 0.01 for systolic and mean arterial pressure, and P less than 0.05 for diastolic pressure). Enalapril was associated with an increasing dose-response relationship across the 2.5-40 mg/day range. The 2.5 mg/dose is effective in some patients; however, doses greater than or equal to 10 mg/day may be necessary to achieve satisfactory blood pressure control.
authors.forename: R
authors.initials: R
authors.lastname: Bergstrand
authors.forename: H
authors.initials: H
authors.lastname: Herlitz
authors.forename: S
authors.initials: S
authors.lastname: Johansson
authors.forename: G
authors.initials: G
authors.lastname: Berglund
authors.forename: A
authors.initials: A
authors.lastname: Vedin
authors.forename: C
authors.initials: C
authors.lastname: Wilhelmsson
authors.forename: H J
authors.initials: HJ
authors.lastname: Gomez
authors.forename: V J
authors.initials: VJ
authors.lastname: Cirillo
authors.forename: J A
authors.initials: JA
authors.lastname: Bolognese
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004151:Dipeptides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004656:Enalapril; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011674:Pulse / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D004151:Dipeptides; D004656:Enalapril