Leukocytosis and low serum IgA in workers exposed to the epoxy compound, t-methyl-3-phenylglycidate.
Forty-nine out of 54 male workers engaged in the production of an epoxy compound, t-methyl-3-phenylglycidate, showed skin symptoms in varying degrees that may be due to the skin-irritative effect of the compound. The exposed workers were also shown to have subjective symptoms which may be related to the irritative property of the compound on surface tissue. Laboratory examinations on the blood obtained from the exposed workers showed significantly higher values of leukocyte concentration as compared with the non-exposed controls. This was chiefly caused by the increase of neutrophilic granulocytes and T-cell lymphocytes. Serum IgA levels of the exposed workers were shown to be significantly lower than those of the control group. Hemoglobin concentration, hematocrit value and red cell count of the exposed workers remained at the same level as those of the control subjects. Liver or kidney damage was not found in biochemical analyses on the sera of exposed workers.
Yamada
Y
Y
Department of Hygiene, Kanazawa Medical University, Ishikawa, Japan.
Kido
T
T
Ishizaki
M
M
Honda
R
R
Tsuritani
I
I
Yamaya
H
H
Nogawa
K
K
D000328:Adult; D009783:Dermatitis, Occupational / Q000139:chemically induced; D004852:Epoxy Compounds / Q000009:adverse effects*; D004988:Ethers, Cyclic / Q000009:adverse effects*; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D007964:Leukocytosis / Q000139:chemically induced*; D008214:Lymphocytes / Q000145:classification; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood / Q000139:chemically induced* / Q000276:immunology; D011422:Propionates / Q000009:adverse effects
D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D007070:Immunoglobulin A; D011422:Propionates; C055263:3-(-methoxyphenyl)glycidic acid methylester