title: Pathogenesis of canine parvovirus-2 in dogs: haematology, serology and virus recovery.
abstract: The pathogenesis of canine parvovirus-2 (CPV-2) was studied in orally inoculated conventional dogs using haematological, serological and virological techniques. Virus was first isolated from mesenteric lymph nodes on day 2 after exposure, tonsil on day 3 and small intestine on day 3. Viraemia occurred subsequently and was present in most dogs on days 4 and 5 after exposure. CPV-2 could be isolated from all tissues during viraemia. Relative pyrexia, lymphopenia and neutropenia occurred on days 5, 6 and 7 after exposure, respectively. Virus excretion in faeces began in most dogs on day 4 and continued despite the appearance of neutralising serum antibody. Specific serum antibody, detected in some dogs as early as day 3 and in all dogs by day 7 after exposure, eliminated viraemia and inhibited virus isolation from tissues in cell culture.
authors.forename: P S
authors.initials: PS
authors.lastname: Carman
authors.forename: R C
authors.initials: RC
authors.lastname: Povey
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D004283:Dog Diseases / Q000097:blood / Q000276:immunology; D004285:Dogs; D005243:Feces / Q000382:microbiology; D006386:Hemagglutination Tests / Q000662:veterinary; D007958:Leukocyte Count / Q000662:veterinary; D007962:Leukocytes / Q000166:cytology; D008214:Lymphocytes / Q000166:cytology; D009500:Neutralization Tests; D009504:Neutrophils / Q000166:cytology; D010321:Parvoviridae / Q000276:immunology / Q000302:isolation & purification; D010322:Parvoviridae Infections / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral