Demonstration of monoclonal IgE by isoelectric focusing: first reported case of IgE myeloma in Australia.
A 56-year-old man who presented with back pain was diagnosed with multiple myeloma. Serum protein analysis by isoelectric focusing identified a monoclonal IgE lambda of unique spectrotype compared with other monoclonal immunoglobulins. The similarity of the spectrotype of this monoclonal IgE to that of two purified monoclonal IgEs suggests that these proteins have a characteristic spectrotype, sufficiently different from those of other immunoglobulin classes to allow its recognition.
McLachlan
R
R
Pathology Department, Peter MacCallum Cancer Institute, Melbourne, Australia.
Grigg
A P
AP
Cornell
F N
FN
Harris
R A
RA
Woodruff
R K
RK
D000911:Antibodies, Monoclonal / Q000032:analysis*; D001416:Back Pain / Q000150:complications; D001797:Blood Protein Electrophoresis / Q000379:methods; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007525:Isoelectric Focusing / Q000379:methods; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000276:immunology*
D000911:Antibodies, Monoclonal; D007073:Immunoglobulin E