A sensory evoked potential comparison of persons 'at risk' for Huntington's disease and hospitalized neurotic patients.
Scalp-recorded sensory evoked potentials (EPs) elicited by left and right median nerve stimulation (LSEP and RSEP), checkerboard pattern flash (VEP) and acoustic click (AEP) were obtained in 22 individuals 'at risk' (AR) for Huntington's disease and 22 hospitalized neurotic patients matched for age, gender and intelligence. EPs of AR subjects were generally similar to those of the neurotic comparison group, in terms of overall configuration; however, mean amplitudes were significantly lower for ARs. While the general amplitude reduction for ARs was seen in all three modalities, the somatosensory modality yielded the most abnormal findings.
Josiassen
R C
RC
Department of Psychiatry, Medical College of Pennsylvania/EPPI, Philadelphia 19129.
Shagass
C
C
Roemer
R A
RA
Mancall
E
E
D000328:Adult; D000344:Afferent Pathways / Q000503:physiopathology; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D008475:Median Nerve / Q000503:physiopathology; D008875:Middle Aged; D009497:Neurotic Disorders / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D012307:Risk Factors; D013003:Somatosensory Cortex / Q000503:physiopathology