Biologic characteristics of four Ewing's sarcomas.
Four Ewing's sarcomas were examined for chromosomal characteristics, growth in cell culture, tumorigenicity in nude mice, and presence of beta-adrenergic receptors. Three tumors were from untreated patients (one obtained directly from the patient and two after growth in nude mice) and one was a metastatic lesion obtained after treatment. All four tumors were diploid or near-diploid, with one or more structural rearrangements. In the metastatic lesion, 21 abnormalities were seen. No specific chromosome aberration was found to be common to all four tumors, although a t(1,16) was observed in two and a t(11;22) in two. Abnormalities involving chromosomes #1, #3, #11, #13, #16, and #22 were each found in two of four tumors. All four tumors were tumorigenic in nude mice; two grew well in cell culture, one of which became an established line, and all four expressed high concentrations of beta-adrenergic receptors.
Workman
M L
ML
Soukup
S W
SW
Neely
J E
JE
Whitsett
J
J
Ballard
E
E
Lampkin
B
B
D000293:Adolescent; D000818:Animals; D002455:Cell Division; D002871:Chromosome Banding; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011379:Prognosis; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D012512:Sarcoma, Ewing / Q000235:genetics / Q000503:physiopathology*
D011943:Receptors, Adrenergic, beta