Associated chronic lymphocytic leukemia and multiple myeloma: origin from a single clone.
We investigated the clonal relationship of malignant cells in a patient affected with both chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). CLL cells and malignant plasma cells synthesized IgG1 kappa and IgA kappa molecules, respectively; these monoclonal Ig shared idiotypic determinants, providing evidence that a single clonal disease occurred in this patient. Furthermore, when leukemic CLL cells were driven to differentiate in vitro to immunoblasts and plasma cells, a switch from IgG to IgA occurred in a significant percentage of cells that were double producers. These data suggest that, in some circumstances, CLL leukemic B cells may reach a more mature state, leading to the occurrence of clinical MM.
Fermand
J P
JP
James
J M
JM
Herait
P
P
Brouet
J C
JC
D001402:B-Lymphocytes / Q000187:drug effects / Q000473:pathology; D002454:Cell Differentiation; D002478:Cells, Cultured; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D002479:Inclusion Bodies / Q000032:analysis; D007945:Leukemia, Lymphoid / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology; D009101:Multiple Myeloma / Q000276:immunology / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D008934:Mitogens