[Model of experimental Pixuna infection in white mice].
The results of the development of a nonfatal model of experimental infection induced by Pixuna alpha-virus and suitable for the evaluation of the effectiveness of antiviral drugs are described. The asymptomatic infection induced in white mice by intranasal inoculation of Pixuna virus is characterized by intensive virus multiplication in the brain and spleen of the animals. In these organs virus reproduction is observed early after infection and amplification of the agent reaches maximum titres within 72 h postinfection. With this model, the main criterion of the effectiveness of antiviral drugs would be their effect on virus reproduction in the spleen and brain.
Chizhov
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Luk'ianova
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RI
D000524:Alphavirus / Q000302:isolation & purification / Q000472:pathogenicity; D000818:Animals; D004195:Disease Models, Animal; D051379:Mice; D013997:Time Factors; D014036:Togaviridae Infections / Q000382:microbiology*
Model' éksperimental'noĭ infektsii Piksuna u belykh mysheĭ.