Comparison of cAMP with other radioprotectors against chronic damage to the rat parotid gland.
Radiation damage to the parotid gland is protectable by cAMP during the first week after irradiation (acute phase), though appreciable recovery occurred later with or without such protection. Further damage developed later (chronic phase, 60-90 days), and cAMP was still protective against this damage with a dose modification factor of 1.86 for gland weight. A summary of the protective factors, acute and chronic, for WR-2721, isoproterenol, and cAMP is included. Chronic damage is about 1.5 times as great as acute, and protection against acute and chronic damage is about equal for all three compounds.
Conger
A D
AD
Sodicoff
M
M
Samel
A
A
D004999:Amifostine / Q000627:therapeutic use; D000818:Animals; D000242:Cyclic AMP / Q000627:therapeutic use*; D005260:Female; D007545:Isoproterenol / Q000627:therapeutic use; D010306:Parotid Gland / Q000187:drug effects / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011837:Radiation-Protective Agents; D000242:Cyclic AMP; D007545:Isoproterenol; D004999:Amifostine