title: Cardiovascular studies during controlled baroreflex activation in the dog: II. Effects of metoprolol and enflurane.
abstract: An experimental model was designed to study circulatory drug effects with or without barostatic reflex influences. In dogs anaesthetized with chloralose, both carotid sinuses were perfused from a femoral by-pass either with systemic arterial pressure or with a pump in order to control the sinus pressure. Cardiac and aortic baroreceptors were denervated. I.v. metoprolol (240 micrograms X kg-1 + 102 micrograms X kg-1 X h-1) with constant carotid sinus pressure and thereby constant baroreceptor activation reduced cardiac output, heart rate, cardiac contractility and left ventricular stroke work index. Systemic vascular resistance increased. This response was independent of the degree of baroreflex activation. During the combined administration of enflurane (1.6% end-tidal concentration) and metoprolol, cardiac performance (cardiac output, stroke volume, heart rate, cardiac contractility and left ventricular stroke work index) was depressed independent of the degree of baroreflex activation. Barostatic reflexes, however, counteracted an observed decrease in systemic vascular resistance. This reflex vascular response was, during metoprolol-enflurane administration, associated with an increased left ventricular end-diastolic pressure.
authors.forename: B A
authors.initials: BA
authors.lastname: Henriksson
authors.forename: B
authors.initials: B
authors.lastname: Biber
authors.forename: D
authors.initials: D
authors.lastname: Lundberg
authors.forename: J
authors.initials: J
authors.lastname: Martner
authors.forename: J
authors.initials: J
authors.lastname: Pontén
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002346:Carotid Sinus / Q000187:drug effects* / Q000502:physiology; D003714:Denervation; D004285:Dogs; D004737:Enflurane / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D008790:Metoprolol / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D011311:Pressoreceptors / Q000187:drug effects* / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D012018:Reflex / Q000187:drug effects / Q000502:physiology; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D011943:Receptors, Adrenergic, beta; D004737:Enflurane; D008790:Metoprolol