[Atrial natriuretic factor in patients with type 1 diabetes mellitus in various stages of diabetic nephropathy].
In this study we investigated circulating atrial natriuretic factor (ANF) concentrations in patients with different stages of diabetic nephropathy. Type 1 diabetic patients with incipient or overt nephropathy had elevated plasma ANF concentrations when compared with nonnephropathic diabetics and normals. Patients having a hyperfiltration only, which might be a risk factor for the development of diabetic nephropathy, had also elevated ANF concentrations. No correlation could be found between ANF concentrations and blood pressure, diabetes duration, age, or parameters of metabolic control. These findings may indicate a role of ANF in the development of diabetic nephropathy. Long-term follow-up studies should be performed to assess the prognostic and diagnostic importance of plasma ANF determinations in diabetic patients.
Sawicki
P
P
Abteilung für Stoffwechsel und Ernährung, Medizinischen Universitätsklinik Düsseldorf.
Heinemann
L
L
Rave
K
K
Berger
M
M
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D003404:Creatinine / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D011507:Proteinuria; D012016:Reference Values
D009320:Atrial Natriuretic Factor; D001786:Blood Glucose; D003404:Creatinine; D006442:Glycated Hemoglobin
Atrialer natriuretischer Faktor bei Patienten mit Typ-1-Diabetes mellitus in verschiedenen Stadien der diabetischen Nephropathie.