Synthesis of new fluorescent spirolactone derivatives: determination of their affinities for aldosterone receptors.
Fluorescent spirolactone derivatives are obtained by coupling 3-carboxylic coumarins to a spirolactone bearing a 3-hydroxypropyl chain in the 7 alpha position. The two esters prepared by this method are highly fluorescent (emission 383 and 408 nm).
Auzou
G
G
INSERM U 300, Montpellier, France.
Nique
F
F
Nedelec
L
L
D000450:Aldosterone / Q000378:metabolism*; D005453:Fluorescence; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D018161:Receptors, Mineralocorticoid; D013148:Spironolactone / Q000138:chemical synthesis* / Q000378:metabolism
D011965:Receptors, Glucocorticoid; D018161:Receptors, Mineralocorticoid; D013148:Spironolactone; D000450:Aldosterone