title: trans-Activation of the human T-cell leukemia virus long terminal repeat correlates with expression of the x-lor protein.
abstract: Cell lines established directly from adult T-cell leukemia-lymphoma patients or immortalized by human T-cell leukemia virus type I (HTLV-I) in vitro that do not produce complete HTLV virions were characterized both for the content of viral proteins and for the presence of trans-acting factors activating gene expression under the control of the HTLV long terminal repeat. The expression of the 42-kilodalton HTLV x-lor product correlated with trans-activation of the long terminal repeat. The implications of this study for understanding the role of the HTLV x-lor product in the initiation and maintenance of T-lymphocyte transformation are discussed.
authors.forename: J G
authors.initials: JG
authors.lastname: Sodroski
authors.forename: W C
authors.initials: WC
authors.lastname: Goh
authors.forename: C A
authors.initials: CA
authors.lastname: Rosen
authors.forename: S Z
authors.initials: SZ
authors.lastname: Salahuddin
authors.forename: A
authors.initials: A
authors.lastname: Aldovini
authors.forename: G
authors.initials: G
authors.lastname: Franchini
authors.forename: F
authors.initials: F
authors.lastname: Wong-Staal
authors.forename: R C
authors.initials: RC
authors.lastname: Gallo
authors.forename: K
authors.initials: K
authors.lastname: Sugamura
authors.forename: Y
authors.initials: Y
authors.lastname: Hinuma
mesh_terms: D017977:Deltaretrovirus / Q000235:genetics*; D005786:Gene Expression Regulation; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D014764:Viral Proteins