Centrally injected atrial natriuretic factor inhibits angiotensin- and osmotically-induced drinking in pigs.
Atrial natriuretic factor 5-28 (atriopeptin III, APIII; 10 micrograms) injected into the cerebral ventricles of young pigs 5 min before injection of either angiotensin II (AII, 300 ng) or hypertonic NaCl (0.74 M) attenuated the subsequent drinking responses to these dipsogens although the latency to the response was not altered. The inhibition lasted for up to 4 days in the case of AII-induced drinking but normal daily water intake was not disrupted. These findings suggest that in the pig APIII may play a role in the central regulation of drinking in response to AII and that it may have a long biological half-life.
Thornton
S N
SN
Department of Behaviour Physiology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge.
Baldwin
B A
BA
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D004326:Drinking / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D009995:Osmosis; D010446:Peptide Fragments; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D013552:Swine
D010446:Peptide Fragments; D012462:Saline Solution, Hypertonic; D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; C054538:atrial natriuretic factor (5-28)