[Percutaneous penetration of mucopolysaccharide-polysulfate ester from a combination preparation].
The cutaneous penetration of mucopolysaccharide polysulfate (MPS) from a commercial available combination drug (Mobilat) could be shown by means of histochemical and immunohistological methods. Deposition of MPS from ointment and gel in corium and subcutis of different animal species has been improved by the keratolytic activity of the salicylic acid component. There are differences in the intensity of absorption of MPS not only in the various animal species, but also caused by the particular galenic preparations investigated.
Elling
H
H
Pharmakologischen Laboratorien des Luitpold-Werkes, Chemisch-pharmazeutische Fabrik, München.
Raake
W
W
D000818:Animals; D004338:Drug Combinations / Q000008:administration & dosage / Q000493:pharmacokinetics; D005260:Female; D005455:Fluorescent Antibody Technique; D005782:Gels; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006651:Histocytochemistry; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009824:Ointments; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012459:Salicylates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D020156:Salicylic Acid; D012869:Skin Absorption; D013045:Species Specificity; D014020:Tissue Extracts / Q000008:administration & dosage / Q000493:pharmacokinetics*
D004338:Drug Combinations; D005782:Gels; D006025:Glycosaminoglycans; D009824:Ointments; D012459:Salicylates; D014020:Tissue Extracts; C039329:mobilat; D020156:Salicylic Acid
Zur perkutanen Penetration von Mucopolysaccharid-polyschwefelsäureester aus einem Kombinationspräparat.