Selective attenuation of sweetened milk consumption by opiate receptor antagonists in male and female rats of the Roman strains.
Male and female rats of the three Roman strains (Roman High-, Roman Low-, and Roman Control Avoidance; RHA, RLA and RCA, respectively) were familiarized with a highly palatable sweetened milk in a daily 30 min test. The animals were never food- or water-deprived prior to the test. Daily milk intake stabilised at a high level before drug tests were initiated. Effects of naloxone, diprenorphine, WIN 44,441-3, MR2266, MR2267, and ICI 154129 on milk consumption were investigated. Naloxone, diprenorphine and MR2266 each had comparable anorectic effects across strains and sexes. WIN 44,441-3 was relatively ineffective; MR2267 and ICI 154129 were without effect on milk consumption.
Cooper
S J
SJ
Barber
D J
DJ
Barbour-McMullen
J
J
D000818:Animals; D001067:Appetite Depressants; D001392:Azocines / Q000494:pharmacology; D001575:Benzomorphans / Q000494:pharmacology; D004174:Diprenorphine / Q000494:pharmacology; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D005260:Female; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology*; D051381:Rats; D011957:Receptors, Opioid / Q000502:physiology*; D012737:Sex Factors; D013045:Species Specificity
D001067:Appetite Depressants; D001392:Azocines; D001575:Benzomorphans; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D004174:Diprenorphine; D009270:Naloxone; C027247:MR 2266; D004743:Enkephalin, Leucine; C036405:ICI 154129; C035969:quadazocine