title: Prostaglandins and other metabolites of arachidonic acid. An overview for the otolaryngologist.
abstract: Metabolites of arachidonic acid have important regulatory functions within several areas of concern to the otolaryngologist. Prostaglandins, composing one group, are involved in smooth-muscle contraction, regulation of renal glomerular blood flow, and in the modulation of immune and allergic responses, inflammation, fever, pain, and tumor growth. A second group, the leukotrienes, may be even more important than prostaglandins in allergy and inflammation. The elusive slow-reacting substance of anaphylaxis belongs in this group. Two other metabolites, thromboxane and prostacyclin, seem to be critical in hemostasis and the metastatic spread of tumors.
authors.forename: M D
authors.initials: MD
authors.lastname: Poole
authors.forename: H C
authors.initials: HC
authors.lastname: Pillsbury
mesh_terms: D000305:Adrenal Cortex Hormones / Q000378:metabolism; D000893:Anti-Inflammatory Agents / Q000378:metabolism; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D001241:Aspirin / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors; D011464:Epoprostenol / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism; D007213:Indomethacin / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism; D017572:Leukotriene A4; D008084:Lipoxygenase / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D010740:Phospholipases / Q000037:antagonists & inhibitors / Q000378:metabolism; D010974:Platelet Aggregation; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism*; D013931:Thromboxanes / Q000378:metabolism
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D017572:Leukotriene A4; D011453:Prostaglandins; D013931:Thromboxanes; D016718:Arachidonic Acid; D011464:Epoprostenol; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D010740:Phospholipases; D001241:Aspirin; D007213:Indomethacin