[Hepatic microsomal delta 9 desaturation of stearic acid in the spontaneously diabetic female BB rat].
delta 9 desaturation of stearic (1-14C) acid has been estimated from incubation of liver microsomes of adult female spontaneously diabetic BB rat, an animal model resembling the spontaneous juvenile diabetes in humans, comparatively to adult female control Wistar rat. The animals were sacrificed, when hyperglycemic, 24 hours after the last insulin injection to the BB rats. Stearic acid delta 9 desaturase activity is drastically depressed in the BB rats when fatty acid composition of liver phospholipids and microsomal total liver lipids are changed in spite of the daily injection of insulin necessary for the BB rats survival.
Mimouni
V
V
Laboratoire de Physiologie Animale et de la Nutrition, Faculté des Sciences Mirande, U.A. CNRS 273, Dijon.
Poisson
J P
JP
Narce
M
M
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000378:metabolism*; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005260:Female; D007328:Insulin / Q000627:therapeutic use; D008862:Microsomes, Liver / Q000201:enzymology*; D051381:Rats; D011913:Rats, Inbred BB; D011919:Rats, Inbred Strains; D013229:Stearic Acids / Q000378:metabolism*
D007328:Insulin; D013229:Stearic Acids; D044943:Fatty Acid Desaturases
delta 9 désaturation microsomale hépatique de l'acide stéarique chez la ratte spontanément diabétique BB.