The effect of nedocromil sodium and sodium cromoglycate on antigen-induced bronchoconstriction in the Ascaris-sensitive monkey.
Nedocromil sodium inhibited the bronchoconstriction caused by antigen challenge in Ascaris-sensitive monkeys and in addition it prevented the release of histamine from mast cells lavaged from sensitive monkeys. Sodium cromoglycate was relatively inactive in both these systems. It is suggested that nedocromil sodium can stabilize both mucosal and connective tissue mast cells and may represent a new type of drug.
Eady
R P
RP
Greenwood
B
B
Jackson
D M
DM
Orr
T S
TS
Wells
E
E
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D001200:Ascaris / Q000276:immunology*; D001982:Bronchial Diseases / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D005260:Female; D008251:Macaca; D008297:Male; D008407:Mast Cells / Q000473:pathology; D017835:Nedocromil; D011804:Quinolines / Q000627:therapeutic use*
D000947:Antigens, Helminth; D011804:Quinolines; D017835:Nedocromil; D004205:Cromolyn Sodium