title: Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells.
abstract: T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing alpha and beta T-cell receptor genes isolated from a male-specific, H-2Db-restricted CD4-8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens determines the differentiation of CD4+8+ thymocytes into either CD4+8- or CD4-8+ mature T cells.
authors.affiliation: Basel Institute for Immunology, Switzerland.
authors.forename: H S
authors.initials: HS
authors.lastname: Teh
authors.forename: P
authors.initials: P
authors.lastname: Kisielow
authors.forename: B
authors.initials: B
authors.lastname: Scott
authors.forename: H
authors.initials: H
authors.lastname: Kishi
authors.forename: Y
authors.initials: Y
authors.lastname: Uematsu
authors.forename: H
authors.initials: H
authors.lastname: Blüthmann
authors.forename: H
authors.initials: H
authors.lastname: von Boehmer
mesh_terms: D000818:Animals; D000943:Antigens, Differentiation; D002454:Cell Differentiation; D005260:Female; D006183:H-2 Antigens; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D011948:Receptors, Antigen, T-Cell; D012641:Selection, Genetic; D013601:T-Lymphocytes / Q000502:physiology*; D006377:T-Lymphocytes, Helper-Inducer; D050378:T-Lymphocytes, Regulatory
chemical_list: D000943:Antigens, Differentiation; D006183:H-2 Antigens; D011948:Receptors, Antigen, T-Cell