Effects of leukotrienes on the electroretinographic profile of the isolated rat retina.
The isolated retina represents an excellent membrane model since it provides a specific electrophysiological response that is easy to quantify. Therefore the authors have tested the effects of B4, C4 and D4 leukotrienes on this model. In the presence of leukotrienes, electrical response generally decreases and survival duration of the isolated retina is generally shortened. No significant difference between the effects of the three tested products has been found. These results are discussed in relation to, on the one hand, the mechanism of intraretinal generation of its electrophysiological signal and, on the other hand, the leukotrienes' role in inflammatory diseases of the retina.
Doly
M
M
Braquet
P
P
Bonhomme
B
B
Vennat
J C
JC
Meyniel
G
G
D000818:Animals; D004596:Electroretinography; D066298:In Vitro Techniques; D007975:Leukotriene B4 / Q000494:pharmacology*; D051381:Rats; D012160:Retina / Q000187:drug effects*; D013189:SRS-A / Q000494:pharmacology*
D013189:SRS-A; D007975:Leukotriene B4