Glucosteroid (GS)-dependent immunomodulation of immunoglobulin biosynthesis in vitro. III. Effect of GS on helper and suppressor cells' Ig production in vitro.
GS inhibit both the function of spontaneously occurring helper and suppressor T cells, but the latter activity appears to be more sensitive. The process of induction of suppressor T cells by Concanavalin A is partly steroid-sensitive. Active ConA-induced suppressors appear to be more resistant to GS.
Korczak-Kowalska
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G
Department of Experimental Immunosuppression, Medical Academy, Warsaw.
Górski
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A
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000502:physiology*; D002478:Cells, Cultured; D003208:Concanavalin A; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000187:drug effects; D011239:Prednisolone / Q000494:pharmacology / Q000502:physiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism
D000276:Adjuvants, Immunologic; D007136:Immunoglobulins; D003208:Concanavalin A; D011239:Prednisolone