[The activity of nonspecific bone marrow and spleen suppressors in the latent period of tumor growth].
Female A/Sn mice aged 2-3 and 11-14 months (with spontaneous adenocarcinomas of the mammary gland and tumor-free) and C57Bl/6 mice were followed after treatment with DMBA. Suppressor cells were tested for the ability to inhibit in vivo antibody responses to sheep erythrocytes by adoptively syngeneically transferred cells. It was demonstrated that the activity of nonspecific suppressors of the bone marrow and spleen increases considerably in the precancer period.
Ogreba
V I
VI
Kusmartsev
S A
SA
Vasil'ev
N V
NV
D015127:9,10-Dimethyl-1,2-benzanthracene; D000230:Adenocarcinoma / Q000276:immunology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology*; D016026:Bone Marrow Transplantation; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced / Q000276:immunology*; D007116:Immunization, Passive; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000276:immunology*; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000276:immunology* / Q000637:transplantation; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014185:Transplantation, Isogeneic
D015127:9,10-Dimethyl-1,2-benzanthracene
Aktivnost' nespetsificheskikh supressorov kostnogo mozga i selezenki v latentnyĭ period opukholevogo rosta.