title: The central vs. peripheral effects of clonidine on ACTH, corticosterone and glucose release.
abstract: The role of central vs. peripheral actions of clonidine was investigated in the rat following the separate and combined administration of clonidine and 2-deoxy-D-glucose (2-DG). Clonidine or 2-DG alone stimulated serum glucose and corticosterone but hypothalamic noradrenaline neuronal activity and ACTH release were stimulated by 2-DG only. The stimulation of noradrenaline neuronal activity and ACTH by 2-DG were totally blocked by clonidine. It was concluded that the increases in serum glucose and corticosterone after clonidine administration were not mediated by central effects but that alpha 2-adrenoceptor agonism by clonidine was responsible for inhibition of hypothalamic noradrenaline neuronal activity and pituitary ACTH release.
authors.forename: G A
authors.initials: GA
authors.lastname: Smythe
authors.forename: J E
authors.initials: JE
authors.lastname: Bradshaw
authors.forename: R M
authors.initials: RM
authors.lastname: Gleeson
authors.forename: H S
authors.initials: HS
authors.lastname: Grunstein
authors.forename: M V
authors.initials: MV
authors.lastname: Nicholson
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003000:Clonidine / Q000494:pharmacology*; D003345:Corticosterone / Q000378:metabolism*; D003847:Deoxyglucose / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001786:Blood Glucose; D008734:Methoxyhydroxyphenylglycol; D000324:Adrenocorticotropic Hormone; D003847:Deoxyglucose; D003000:Clonidine; C010117:3,4-dihydroxyphenylglycol; D003345:Corticosterone; D009638:Norepinephrine