Effects of vitamin B12 and B6 on 2,5-hexanedione-induced neuropathy.
The therapeutic effect of Vitamin B12 or Vitamin B6 on 2,5-hexanedione induced-neuropathy in animals was examined by using our electrodiagnostic technique in order to investigate the mechanism of the development of the neuropathy. Pyridoxal phosphate and two forms of Vitamin B12 were administered to rats intoxicated by the neurotoxin for a period of 18 weeks, and the sensory and motor fiber conduction velocity and the motor distal latency of the tail nerve were periodically determined. None of the groups treated with the therapeutic drugs exhibited a definite improvement in the nerve fiber conduction velocity and motor distal latency of the rat tail nerve, as compared with those of the 2,5-hexanedione-treated controls.
Misumi
J
J
Nagano
M
M
Kaisaku
J
J
Hitoshi
T
T
D000818:Animals; D006588:Hexanones / Q000633:toxicity*; D007659:Ketones / Q000633:toxicity*; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D011736:Pyridoxine / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D014805:Vitamin B 12 / Q000494:pharmacology* / Q000627:therapeutic use
D006588:Hexanones; D007659:Ketones; C011269:2,5-hexanedione; D011736:Pyridoxine; D014805:Vitamin B 12