Changes in adrenal function as a possible mechanism for elevation of serum glucose by a single large dose of fluoride.
Serum glucose was elevated immediately after ip administration of a single large dose of fluoride (NaF 35 mg/kg) to rats. Moreover, elevation of serum glucose following ip administration of 35 mg/kg of fluoride to rats was suppressed by adrenalectomy, dibenamine, or propranolol, but not by thyroid-parathyroidectomy. The elevation of serum glucose was associated with enhancement of glucose-6-phosphatase activities in liver and kidney in fluoride-treated rats.
Suketa
Y
Y
Asao
Y
Y
Kanamoto
Y
Y
Sakashita
T
T
Okada
S
S
D015065:17-Hydroxycorticosteroids / Q000097:blood / Q000652:urine; D000311:Adrenal Glands / Q000187:drug effects*; D000818:Animals; D001786:Blood Glucose; D003983:Dibenzylchlorethamine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005943:Gluconeogenesis / Q000187:drug effects; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D010280:Parathyroid Glands / Q000601:surgery; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013965:Thyroidectomy
D015065:17-Hydroxycorticosteroids; D001786:Blood Glucose; D003983:Dibenzylchlorethamine; D012969:Sodium Fluoride; D011433:Propranolol; D005952:Glucose-6-Phosphatase; D004837:Epinephrine