Nonenzymatic and enzymatic hydrolysis of 5-fluoro-2'-deoxyuridine (FUdR) esters.
The chemical and enzymatic reactivity of 5-fluoro-2'-deoxyuridine prodrugs esterified at the 3' and 5' positions with several acyl groups has been investigated. The enzymatic reactivity was affected by the acyl structure, the site of esterification, and the number of esters in the prodrug molecule.
Kawaguchi
T
T
Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.
Fukushima
S
S
Hayashi
Y
Y
Nakano
M
M
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004950:Esterases / Q000032:analysis; D005467:Floxuridine / Q000032:analysis*; D006801:Humans; D006868:Hydrolysis; D007700:Kinetics; D013552:Swine
D005467:Floxuridine; D004950:Esterases