[Hepatitis B virus, serological markers of viral infections and humoral immunity in alcoholic cirrhosis].
In order to define the role of hepatitis B virus (HBV) in alcoholic liver disease and to study the relationship between HBV and other common viruses, the serological markers of viral disease (HBV, Rubella, Polio, Herpes, and Cytomegalovirus-CMV) were compared in 163 patients with alcoholic cirrhosis (group C), 100 patients with alcoholic steatosis (group S) and in 168 non-alcoholic control subjects (group NA). A significantly increased prevalence of HBV markers in group C was related to the presence of anti-HBc antibodies, in 10.5 p. 100 of cirrhotic patients, vs. 1.2 p. 100 in group S and 1 p. 100 in group NA (p less than 0.01). In cirrhotic patients with HBV markers (HBV +) incidence of alcoholic hepatitis was 4 times lower and the total duration of alcohol overconsumption was significantly lower than in cirrhotic patients without these markers (HBV-). Hepatic function tests were not different in HBV + and HBV- cirrhotic patients, excepted for the ASAT/ALAT ratio (1.55 +/- 0.10 vs. 1.92 +/- 0.12; p less than 0.05). Prevalence of anti-CMV antibodies, and anti-herpes greater than 1/100 antibodies, was significantly increased in S and C groups (p less than 0.01). Anti-Rubella, Polio, and CMV antibody titers were higher (p less than 0.05) in HBV + than in HBV- cirrhotic patients. In cirrhotic subjects, titers of these 3 anti-virus antibodies were not related to alcoholic hepatitis or to IgG and IgM concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)
Vetter
D
D
Doffoël
M
M
Gut
J P
JP
Doffoël
S
S
North
M L
ML
Charrault
A
A
Ventre
G
G
Mayer
S
S
Bockel
R
R
D000914:Antibodies, Viral / Q000032:analysis*; D003176:Complement C3 / Q000032:analysis*; D003181:Complement C4 / Q000032:analysis*; D003587:Cytomegalovirus / Q000276:immunology; D005235:Fatty Liver, Alcoholic / Q000276:immunology; D005260:Female; D006509:Hepatitis B / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006512:Hepatitis B Core Antigens / Q000276:immunology; D006519:Hepatitis, Alcoholic / Q000209:etiology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D008104:Liver Cirrhosis, Alcoholic / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D017955:Poliovirus / Q000276:immunology; D012412:Rubella virus / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology
D000914:Antibodies, Viral; D003176:Complement C3; D003181:Complement C4; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D007136:Immunoglobulins
Virus de l'hépatite B, marqueurs sérologiques d'infections virales et immunité humorale au cours de la cirrhose alcoolique.