title: Effects of LTB4 and Ca++ ionophore A23187 on the release by human alveolar macrophages of factors controlling fibroblast functions.
abstract: Cultured human alveolar macrophages from smokers with lung cancer produced spontaneously variable amounts of factors stimulating fibroblast proliferation and production of prostaglandin E2 and collagenase by fibroblasts. These biological activities belong to molecules similar or identical to interleukin 1. Exogenous leukotriene B4 added to alveolar macrophage cultures increased the production of these factors. The Ca++ ionophore A23187 was found to have similar effects. By the control of monokine production, leukotriene B4 locally released by inflammatory cells may modulate lung fibroblast functions.
authors.forename: B
authors.initials: B
authors.lastname: Polla
authors.forename: B
authors.initials: B
authors.lastname: De Rochemonteix
authors.forename: A F
authors.initials: AF
authors.lastname: Junod
authors.forename: J M
authors.initials: JM
authors.lastname: Dayer
mesh_terms: D000001:Calcimycin / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D015232:Dinoprostone; D005260:Female; D005347:Fibroblasts / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D007975:Leukotriene B4 / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008297:Male; D003012:Microbial Collagenase / Q000096:biosynthesis; D008875:Middle Aged; D015846:Monokines; D011458:Prostaglandins E / Q000096:biosynthesis; D011506:Proteins / Q000378:metabolism*; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000378:metabolism
chemical_list: D015846:Monokines; D011458:Prostaglandins E; D011506:Proteins; D007975:Leukotriene B4; D000001:Calcimycin; D003012:Microbial Collagenase; D015232:Dinoprostone