Hypertension in autosomal dominant polycystic kidney disease.
Autosomal dominant polycystic kidney disease (ADPKD) has been shown to be associated with a greater than 50 percent incidence of hypertension prior to deterioration in renal function as assessed by glomerular filtration rate. The present study provides evidence for increased cardiac pre-load, as assessed by plasma atrial natriuretic factor (ANF) and cardiac index, in hypertensive as compared to normotensive ADPKD. The hypertensive ADPKD patients exhibited an increased renal vascular resistance as compared to the normotensive patients in spite of comparable glomerular filtration rates. It is hypothesized that the renal involvement of hypertensive ADPKD patients causes an impaired renal response to the observed increase in cardiac index, and also may release a venoconstrictor (such as angiotensin) which contributes to the enhanced cardiac pre-load and thus the hypertension.
Bell
P E
PE
University of Colorado School of Medicine, Denver.
Hossack
K F
KF
Gabow
P A
PA
Durr
J A
JA
Johnson
A M
AM
Schrier
R W
RW
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood; D002302:Cardiac Output; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D006977:Hypertension, Renal / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009318:Natriuresis; D010953:Plasma Volume; D007690:Polycystic Kidney Diseases / Q000150:complications / Q000235:genetics*; D012084:Renin-Angiotensin System; D012982:Sodium, Dietary / Q000008:administration & dosage
D012982:Sodium, Dietary; D009320:Atrial Natriuretic Factor