MPP+ depletes retinal dopamine and induces D-1 receptor supersensitivity.
Intraocular administration of 1-methyl-4-phenylpyridinium ion (MPP+) to mice resulted in a dose-dependent depletion of retinal dopamine (DA) and 3,4-dihydroxyphenylacetic acid. Pretreatment with benztropine partially prevented the MPP+-induced depletion. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was less active than MPP+ for depleting DA when administered by the same route and pretreatment with deprenyl partially prevented the depletion. Supersensitivity of retinal D-1 receptors resulted following MPP+-induced DA depletion.
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Department of Pharmacology, Ohio State University College of Medicine, Columbus 43210.
Neff
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Hadjiconstantinou
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D015655:1-Methyl-4-phenylpyridinium; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009498:Neurotoxins / Q000494:pharmacology*; D011726:Pyridinium Compounds / Q000494:pharmacology*; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology; D017447:Receptors, Dopamine D1; D012160:Retina / Q000378:metabolism*
D009498:Neurotoxins; D011726:Pyridinium Compounds; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D015655:1-Methyl-4-phenylpyridinium; D004298:Dopamine