title: Presence of the atrial natriuretic factor (ANF) in human ascitic fluid.
abstract: Presence of atrial natriuretic factor (ANF)-like material was demonstrated by radioimmunoassay in ascitic fluid of 14 patients with cirrhosis of the liver. Immunoreactive ANF concentrations (M +/- SEM) were 2.4 +/- 0.5 fmol/ml in ascites, significantly lower (p less than 0.001) than the corresponding plasma concentrations of 15.5 +/- 2.6 fmol/ml. High performance gel permeation chromatography and reverse phase high performance chromatography of the ascitic ANF immunoreactivity showed correspondence to the alpha human ANF (99-126). ANF levels in ascites were significantly (p less than 0.01) correlated to levels in plasma (r = 0.66).
authors.affiliation: Medizinische Klinik II and I, Klinikum Grosshadern Munich, Federal Republic of Germany.
authors.forename: A L
authors.initials: AL
authors.lastname: Gerbes
authors.forename: A M
authors.initials: AM
authors.lastname: Vollmar
authors.forename: Y
authors.initials: Y
authors.lastname: Xie
authors.forename: R M
authors.initials: RM
authors.lastname: Arendt
mesh_terms: D001201:Ascites / Q000209:etiology / Q000378:metabolism*; D009320:Atrial Natriuretic Factor / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000378:metabolism*; D011863:Radioimmunoassay / Q000379:methods
chemical_list: C472955:NPPA protein, human; D009320:Atrial Natriuretic Factor