Lack of effect of synthetic atrial natriuretic factor on rubidium uptake by human erythrocytes.
The effect of synthetic atrial natriuretic factor on the ouabain-sensitive and the furosemide-sensitive rubidium uptake by human erythrocytes has been studied. This peptide with potent diuretic and natriuretic effects did not affect any rubidium uptake system at concentrations of 10(-7) and 10(-9) M. These results do not support that the natriuretic effect is based on the inhibition of active transport systems in the renal tubules.
Hernando
N
N
Caramelo
C
C
Tejedor
A
A
Fernandez-Cruz
A
A
López-Novoa
J M
JM
D009320:Atrial Natriuretic Factor; D001693:Biological Transport, Active / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D009124:Muscle Proteins / Q000494:pharmacology*; D009318:Natriuresis; D010042:Ouabain / Q000494:pharmacology; D012413:Rubidium / Q000097:blood*; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood
D009124:Muscle Proteins; C472955:NPPA protein, human; D010042:Ouabain; D005665:Furosemide; D009320:Atrial Natriuretic Factor; D000254:Sodium-Potassium-Exchanging ATPase; D012413:Rubidium