Cardiovascular effects of dobutamine and converting enzyme inhibition in rats with diabetic ketoacidosis.
We investigated cardiac and peripheral hemodynamics in rats with streptozotocin-induced diabetes mellitus in comparison to normal controls. Diabetic rats showed a significantly decreased cardiac output and heart rate, with unchanged mean blood pressures. Regional blood flows were unchanged except for renal blood flow which was significantly lower. The low output state associated with diabetes was reversed by angiotensin converting enzyme inhibition with MK-422, but not with dobutamine, although both agents caused similar reduction in peripheral vascular resistance. However, despite improved left ventricular performance, renal perfusion did not improve after MK-422.
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D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D002395:Catecholamines / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D016883:Diabetic Ketoacidosis / Q000201:enzymology / Q000503:physiopathology*; D004151:Dipeptides / Q000494:pharmacology; D004280:Dobutamine / Q000494:pharmacology*; D015773:Enalaprilat; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors; D002395:Catecholamines; D004151:Dipeptides; D004280:Dobutamine; D015773:Enalaprilat