Griseolic acid, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. II. The structure of griseolic acid.
Griseolic acid, a potent inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase, was isolated from the fermentation broth of Streptomyces griseoaurantiacus SANK 63479. Treatment of griseolic acid with HCl-MeOH gave adenine and pseudo-sugar. The structure of griseolic acid, adenine nucleoside type structure, was elucidated by chemical degradation and X-ray analysis, and was shown to be structure 1.
Takahashi
S
S
Nakagawa
F
F
Kawazoe
K
K
Furukawa
Y
Y
Sato
S
S
Tamura
C
C
Naito
A
A
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000107:Acetylation; D000241:Adenosine / Q000031:analogs & derivatives*; D002845:Chromatography; D003461:Crystallography; D003978:Diazomethane; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol; D008968:Molecular Conformation
D003978:Diazomethane; C046499:griseolic acid; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000241:Adenosine; D000432:Methanol