Early visual information processing in depressive patients treated with ORG 2766 (an ACTH 4-9 analogue).
Twenty-one depressive patients (7 males, 14 females, mean age 61.6, range 50-72) participated in an inter- and intraindividual double-blind comparative study between the ACTH 4-9 analogue (ORG 2766), 80 mg daily during 14-28 days, and placebo. The temporal thresholds for detection and recognition of rapidly presented single letters were assessed by a tachistoscopic technique. The results indicate that the peptide has a reducing effect on recognition threshold, and appears to improve automatic, preattentive levels of information processing possibly involved in the transfer of information from the peripheral icon to the cortical centre, i.e. from iconic storage to short-term memory.
d'Elia
G
G
Frederiksen
S O
SO
Bengtsson
B O
BO
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000368:Aged; D000928:Antidepressive Agents; D003071:Cognition / Q000187:drug effects; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D008606:Mental Processes / Q000187:drug effects*; D008875:Middle Aged; D010446:Peptide Fragments / Q000627:therapeutic use*; D011930:Reaction Time / Q000187:drug effects; D014796:Visual Perception / Q000187:drug effects*
D000928:Antidepressive Agents; D010446:Peptide Fragments; C013765:Org 2766; D000324:Adrenocorticotropic Hormone