title: Effects of anesthetic induction on myocardial function and metabolism: a comparison of fentanyl, sufentanil and alfentanil.
abstract: Anaesthetic induction may induce myocardial ischaemia. A prospective randomized trial was instituted to compare the effect on ventricular function and myocardial metabolism of induction with fentanyl (FEN) or its analogues sufentanil (SUF) or alfentanil (ALF) in 96 patients undergoing elective coronary artery bypass grafting (CABG). Haemodynamic, metabolic (coronary sinus oxygen and lactate extraction) and gated ventriculographic measurements were made awake pre-induction (PRE), after induction (IND) and after intubation (INT). Induction was performed with FEN 75 micrograms.kg-1, SUF 15 micrograms.kg-1 or ALF 125 micrograms.kg-1 and metocurine. Fentanyl induction was associated with the greatest stability of mean arterial pressure (MAP), cardiac performance, and systolic function without associated myocardial lactate production. SUF produced the greatest depression of systolic function (p less than 0.05) but without haemodynamic instability or myocardial lactate production in all but one patient. Induction with ALF produced the greatest reduction in MAP (p less than 0.05) associated with the greatest decrease in diastolic compliance (p less than 0.05) and 50 per cent incidence of myocardial lactate production (p less than 0.05) with no significant change in coronary blood flow or myocardial oxygen consumption.
authors.affiliation: Division of Clinical Biochemistry, Toronto General Hospital, University of Toronto, Ontario.
authors.forename: D R
authors.initials: DR
authors.lastname: Miller
authors.forename: M
authors.initials: M
authors.lastname: Wellwood
authors.forename: S J
authors.initials: SJ
authors.lastname: Teasdale
authors.forename: D
authors.initials: D
authors.lastname: Laidley
authors.forename: J
authors.initials: J
authors.lastname: Ivanov
authors.forename: P
authors.initials: P
authors.lastname: Young
authors.forename: M
authors.initials: M
authors.lastname: Madonik
authors.forename: P
authors.initials: P
authors.lastname: McLaughlin
authors.forename: D A
authors.initials: DA
authors.lastname: Mickle
authors.forename: R D
authors.initials: RD
authors.lastname: Weisel
mesh_terms: D015760:Alfentanil; D000777:Anesthetics / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000139:chemically induced / Q000601:surgery; D005260:Female; D005283:Fentanyl / Q000009:adverse effects / Q000031:analogs & derivatives; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D017409:Sufentanil
chemical_list: D000777:Anesthetics; D015760:Alfentanil; D017409:Sufentanil; D005283:Fentanyl