title: Scanning electron microscopic autoradiography of lung.
abstract: Scanning electron microscopic (SEM) autoradiography of the lung is being used to determine the distribution of inhaled, alpha particle-emitting, plutonium dioxide particles. SEM autoradiography provides high visual impact views of alpha activity. Particles irradiating the bronchiolar epithelium were detected both on the bronchiolar surface and in peribronchiolar alveoli. The technique is being used to obtain quantitative data on the clearance rates of plutonium particles from bronchi and bronchioles.
authors.affiliation: Biology and Chemistry Department, Pacific Northwest Laboratory, Richland, Washington 99352.
authors.forename: K E
authors.initials: KE
authors.lastname: Lauhala
authors.forename: C L
authors.initials: CL
authors.lastname: Sanders
authors.forename: K E
authors.initials: KE
authors.lastname: McDonald
mesh_terms: D000818:Animals; D001345:Autoradiography; D001980:Bronchi / Q000378:metabolism; D005260:Female; D008168:Lung / Q000032:analysis* / Q000378:metabolism / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D011005:Plutonium / Q000032:analysis* / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D013047:Specific Pathogen-Free Organisms; D014018:Tissue Distribution
chemical_list: C026885:plutonium dioxide; D011005:Plutonium