The D-1 dopamine receptor.
The D-1 receptor will provide a fruitful ground for many scientists in the coming years. Pure biochemists will attempt to isolate, purify and sequence the molecule itself. Functional biochemists will study the mechanisms whereby the receptor regulates adenylate cyclase activity. Physiologists will attempt to study the consequences of stimulating the receptor in either the brain or in peripheral tissues. Animal behavioralists will attempt to understand how the receptor participates in the generation of animals response to dopaminergic drugs (both agonists and antagonists). Finally, it remains to be determined if any novel therapeutic agents targeted towards the D-1 receptor will become commercially viable compounds.
Kebabian
J W
JW
Abbott Laboratories, Abbott Park, IL 60064.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000502:physiology; D010280:Parathyroid Glands / Q000502:physiology; D011954:Receptors, Dopamine / Q000378:metabolism / Q000502:physiology*; D017447:Receptors, Dopamine D1; D012160:Retina / Q000502:physiology
D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D000262:Adenylyl Cyclases