Subclinical and clinical bluetongue disease in cattle: clinical, pathological and pathogenic considerations.
Calves immunized (sensitized) with alcide-inactivated bluetongue virus (BTV) developed immunoglobulin (Ig) E-specific antibody to BTV. Development of clinically apparent disease occurred after challenge with virulent BTV, and lesions correlated with peak levels of virus-specific IgE, an eosinophilic dermatitis, and high concentrations of histamine in the skin. IgE may be important in the pathogenesis of clinical bluetongue (BT) disease in cattle.
Anderson
G A
GA
Stott
J L
JL
Gershwin
L J
LJ
Osburn
B I
BI
D000818:Animals; D001819:Bluetongue / Q000276:immunology* / Q000503:physiopathology / Q000517:prevention & control; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000503:physiopathology / Q000517:prevention & control; D002927:Cimetidine / Q000494:pharmacology; D007114:Immunization; D007073:Immunoglobulin E / Q000096:biosynthesis; D007978:Levamisole / Q000494:pharmacology; D012756:Sheep
D007978:Levamisole; D007073:Immunoglobulin E; D002927:Cimetidine