[Mechanisms of the disorder of the hormonal regulation of plasma membrane adenylate cyclase in the rat liver during early ontogeny under in vitro irradiation].
Possible reasons for the previously detected inhibitory effect of gamma-radiation (100-1000 Gy in vitro) on isoproterenol-stimulated activity of adenylate cyclase (AC) of the liver plasma membranes of a 20-day-old rat fetus were investigated. It was discovered that the number of beta-adrenergic receptors was reduced. Analysis of basal and fluorine-stimulated activities of AC attests to the radiation-induced damage to catalytic and N-regulatory proteins. The radiation-induced derangement of membrane lipids, where AC functions, is shown.
Ushakova
T E
TE
Slozhenikina
L V
LV
Fialkovskaia
L A
LA
Kuzin
A M
AM
D000262:Adenylyl Cyclases / Q000528:radiation effects*; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology / Q000528:radiation effects; D004082:Dihydroalprenolol / Q000378:metabolism; D004307:Dose-Response Relationship, Radiation; D004789:Enzyme Activation / Q000187:drug effects / Q000528:radiation effects; D005333:Fetus; D005720:Gamma Rays; D007545:Isoproterenol / Q000494:pharmacology; D008099:Liver / Q000201:enzymology / Q000528:radiation effects*; D011485:Protein Binding / Q000528:radiation effects; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000201:enzymology / Q000528:radiation effects
D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D000262:Adenylyl Cyclases; D007545:Isoproterenol
Mekhanizmy narusheniia gormonal'noĭ reguliatsii adenilattsiklazy plazmaticheskikh membran pecheni krysy v khode rannego ontogeneza v usloviiakh oblucheniia in vitro.