Pharmacological investigations on anti-inflammatory activity of tryptamide (3-nicotinoyl-tryptamine).
The study concerned anti-inflammatory activity of a new tryptamine derivative - tryptamide. This preparation was effective in nonspecific inflammations and those involving immune mechanisms. Only postadjuvant inflammation appeared resistant to its effect. Its particular effectiveness was noted in the experimentally-induced iridocyclitis. Only in few tests, tryptamide was more effective than the reference drug phenylbutazone; in some cases the effect of both drugs was similar, but in the majority of cases tryptamide proved less effective.
Giełdanowski
J
J
Department of Experimental Therapy, Polish Academy of Sciences, Wroclaw.
Kowalczyk-Bronisz
S H
SH
Błaszczyk
B
B
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001752:Blast Crisis; D002351:Carrageenan / Q000633:toxicity; D004137:Dinitrochlorobenzene / Q000633:toxicity; D005260:Female; D006085:Graft Survival / Q000187:drug effects; D006168:Guinea Pigs; D008297:Male; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000633:toxicity; D016038:Skin Transplantation; D014363:Tryptamines / Q000494:pharmacology*; D014374:Tuberculin Test
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004137:Dinitrochlorobenzene; D014363:Tryptamines; D009536:Niacinamide; C057564:tryptamide; D012701:Serotonin; D002351:Carrageenan; D010653:Phenylbutazone