Prostanoid modulation (mediation?) of certain behavioral effects of ethanol.
Prostaglandin E1 (PGE1) and prostanoid precursor fatty acids enhance the acute sedative effects of ethanol in mice, and reduce the intensity of withdrawal after chronic exposure to ethanol. Aspirin, and other inhibitors of prostanoid synthesis, attenuate ethanol's sedative effects, and interfere with the beneficial effects of prostanoid precursors (but not of PGE1 itself) in withdrawal. Neither aspirin nor indomethacin administered alone affect withdrawal behavior. In contrast, ethanol impairment of rotorod behavior is not affected by prostanoid precursors nor by aspirin. These findings support a role for prostanoids as modulators (? mediators) of certain direct effects of ethanol and a role for prostanoid deficiency in the pathogenesis of withdrawal behavior.
Segarnick
D J
DJ
Cordasco
D M
DM
Rotrosen
J
J
D000437:Alcoholism / Q000503:physiopathology*; D000527:Alprostadil; D000818:Animals; D001241:Aspirin; D001921:Brain / Q000503:physiopathology*; D000431:Ethanol / Q000009:adverse effects; D005227:Fatty Acids / Q000502:physiology*; D005228:Fatty Acids, Essential; D005231:Fatty Acids, Unsaturated; D006801:Humans; D007052:Ibuprofen; D007213:Indomethacin; D008041:Linoleic Acids; D008042:Linolenic Acids; D008297:Male; D051379:Mice; D031665:Oenothera biennis; D010938:Plant Oils; D011453:Prostaglandins / Q000502:physiology*; D011458:Prostaglandins E; D011466:Prostanoic Acids / Q000502:physiology*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology; D017965:gamma-Linolenic Acid
D005227:Fatty Acids; D005228:Fatty Acids, Essential; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D008042:Linolenic Acids; D010938:Plant Oils; D011453:Prostaglandins; D011458:Prostaglandins E; D011466:Prostanoic Acids; D000431:Ethanol; C028498:evening primrose oil; D017965:gamma-Linolenic Acid; D000527:Alprostadil; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin