Intravenous injection of ioxilan, iohexol and diatrizoate. Effects on urine profiles in the rat.
Effects of intravenous ioxilan, a new third generation non-ionic contrast medium, diatrizoate, iohexol and saline on urine profiles were compared. Albumin, glucose, sodium, phosphate, and the enzymes NAG, LDH and GGT were followed in 24 normal rats over 7 days. Diatrizoate significantly affected all profile components during the first two hours. Albuminuria was significantly greater after diatrizoate than after iohexol or ioxilan, and excretion of glucose, LDH and GGT was significantly higher than after ioxilan. Both iohexol and ioxilan increased the excretion of albumin, LDH and GGT, while iohexol also significantly increased excretion of glucose and sodium. There was a greater excretion of glucose and GGT after iohexol than after ioxilan. Saline did not induce any changes. At day 7, serum sodium, urea, creatinine, and albumin were normal for all test substances, and kidney histology revealed no difference between the groups of animals. It is thus concluded that both high osmolar ionic and low osmolar non-ionic contrast media may cause temporary glomerular and tubular dysfunction in rats. In this model, the kidney is affected most by diatrizoate, less by iohexol, and least by ioxilan.
Thomsen
H S
HS
Department of Diagnostic Radiology, University of Copenhagen, Herlev, Denmark.
Dorph
S
S
Mygind
T
T
Sovak
M
M
Nielsen
H
H
Rygaard
H
H
Larsen
S
S
Skaarup
P
P
Hemmingsen
L
L
Holm
J
J
D000818:Animals; D003287:Contrast Media / Q000633:toxicity*; D003973:Diatrizoate / Q000008:administration & dosage / Q000633:toxicity*; D007275:Injections, Intravenous; D007472:Iohexol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014556:Urine / Q000032:analysis*
D003287:Contrast Media; D003973:Diatrizoate; D007472:Iohexol; C055357:ioxilan