[Clinical, immunologic and therapeutic aspects of endangiitis obliterans].
In the period of 1975-1983 twenty-three patients with thromboangiitis obliterans were examined at the Surgical Clinic of the Medical Academy of Magdeburg. The diagnosis was established clinically, angiographically histologically and immunologically. In 7 out of 12 patients histology revealed inflammatory vascular alterations including lymphocyte infiltrates throughout the entire vessel wall and also in the perivascular area. Immunohistology showed in 10 out of 15 patients segmental granular fluorescence identifiable as deposits of IgM and IgG. In 6 cases a complement formation was found. The endangiitis group revealed more frequent and increased immune complexes concentrations. Circulating immune complexes were established by phase-locked radio-immunoassay. The therapy is depended on the localization of the obliteration and can be a lumbar sympathectomy or a vascular reconstruction.
Lambrecht
R
R
Institut für Medizinische Mikrobiologie, Medizinischen Akademie Magdeburg.
Heinrich
P
P
Ladetzki
H H
HH
Morenz
J
J
D000328:Adult; D001158:Arteries / Q000473:pathology; D003166:Complement Activating Enzymes / Q000032:analysis*; D003172:Complement C1 / Q000032:analysis*; D015922:Complement C1q; D005455:Fluorescent Antibody Technique; D006801:Humans; D007105:Immune Complex Diseases / Q000473:pathology*; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008297:Male; D011379:Prognosis; D013919:Thromboangiitis Obliterans / Q000473:pathology* / Q000601:surgery
D003172:Complement C1; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015922:Complement C1q; D003166:Complement Activating Enzymes
Klinische, immunologische und therapeutische Aspekte der Endangiitis obliterans.