title: Leishmania infantum infection rates in Phlebotomus perniciosus fed on naturally infected dogs under antimonial treatment.
abstract: Dogs naturally infected with Leishmania infantum Nicolle were treated with three courses of meglumine antimoniate. Changes were observed in the dogs' clinical signs, antibody titres and in infection rates of Phlebotomus perniciosus Newstead fed on the dogs. A large reduction in the sandfly infection rate was observed for 4-5 months after the first treatment. The use of antimonial drugs is advocated for the control of canine leishmaniasis and to reduce risks of L.infantum transmission.
authors.affiliation: Laboratorio di Parassitologia, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Gradoni
authors.forename: M
authors.initials: M
authors.lastname: Maroli
authors.forename: M
authors.initials: M
authors.lastname: Gramiccia
authors.forename: F
authors.initials: F
authors.lastname: Mancianti
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D007303:Insect Vectors / Q000469:parasitology; D007893:Leishmania donovani / Q000187:drug effects / Q000502:physiology*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000662:veterinary*; D008536:Meglumine / Q000627:therapeutic use*; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000627:therapeutic use*; D010691:Phlebotomus / Q000469:parasitology*
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate