Induction of angiosarcoma by a c-erbB transducing virus.
Recently, 12 new transductions of c-erbB have been identified in a series of Rous-associated virus type 1-induced erythroleukemias. During the passage of these new transducing viruses it has become apparent that the erythroleukemia in chicken 5005 contained two different c-erbB transducing viruses. One induces erythroblastosis, whereas the second induces angiosarcoma. The angiosarcoma- and erythroblastosis-inducing viruses appear to have had a common ancestor, since tumors induced by each contain a novel, 4.3-kilobase c-erbB-related EcoRI fragment. The angiosarcoma-inducing virus has been named avian angiosarcoma virus and is designated for the chicken in which it originated.
Tracy
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Woda
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Robinson
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D000818:Animals; D001353:Avian Leukosis / Q000209:etiology; D001354:Avian Leukosis Virus / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D001483:Base Sequence; D002645:Chickens; D006394:Hemangiosarcoma / Q000209:etiology* / Q000473:pathology; D014161:Transduction, Genetic