Increased platelet aggregation and release reaction in myotonic dystrophy.
Platelet aggregation (PA) induced by (-)-epinephrine and adenosine diphosphate (ADP) was studied in 16 patients with myotonic dystrophy (MyD) and 14 healthy subjects. Plasma beta-thromboglobulin level (beta-TG), a useful marker of in vivo platelet release reaction, as well as in vitro 5-[14C]hydroxytryptamine (5-HT) release, were also studied. The extent of PA induced by (-)-epinephrine at 1 and 3 min and by ADP at 3 min was significantly higher in the patients than in controls. Plasma beta-TG and ADP- or epinephrine-induced platelet 5-HT release were also increased in MyD patients. These results suggest that an abnormality in release as well as in alpha 2-receptor functioning occurs in the platelets of MyD patients. The relation of this abnormality to changes in Ca2+ fluxes through the platelet membrane is discussed.
Bornstein
N M
NM
Department of Neurology, Tel Aviv University, Ramat Aviv, Israel.
Zahavi
M
M
Korczyn
A D
AD
Zahavi
J
J
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000328:Adult; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009223:Myotonic Dystrophy / Q000097:blood* / Q000503:physiopathology; D010974:Platelet Aggregation / Q000187:drug effects*; D012701:Serotonin / Q000502:physiology; D001620:beta-Thromboglobulin / Q000502:physiology
D001620:beta-Thromboglobulin; D012701:Serotonin; D000244:Adenosine Diphosphate; D004837:Epinephrine