title: [Cellular responses and the H+ pump in the vacuolar system].
abstract: Intracellular acidic compartments are now recognized to be ubiquitous in the vacuolar system of eukaryotic cells, where the unique ATP-dependent H+ pump (s) functions to maintain their internal low pH. Furthermore, various basic substances and acidic ionophores have been found to raise the internal pH of these compartments to neutrality. These chemicals, on the other hand, have been found to affect various biological reactions in multicellular organisms, including those involved in intercellular communication. The properties of the H+ pump of the vacuolar system and its role in cellular responses are described.
authors.forename: S
authors.initials: S
authors.lastname: Ohkuma
mesh_terms: D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D002450:Cell Communication; D002451:Cell Compartmentation; D002463:Cell Membrane Permeability; D004705:Endocytosis; D005110:Extracellular Space / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000166:cytology; D008247:Lysosomes / Q000378:metabolism*; D011522:Protons; D051381:Rats
chemical_list: D011522:Protons; D000255:Adenosine Triphosphate