title: Effect of metergoline, fenfluramine, and 8-OHDPAT on catalepsy induced by haloperidol or morphine.
abstract: The influences of the indirect serotonin agonist fenfluramine (5; 10 mg/kg s.c.), the serotonin antagonist metergoline (5; 10 mg/kg s.c.) and the 5-HT1A agonist 8-OHDPAT (0.1; 0.2; 0.46 mg/kg s.c.) on haloperidol-induced catalepsy in rats or mice and on morphine-induced catalepsy in rats were studied. Morphine-induced catalepsy was enhanced by fenfluramine and attenuated by metergoline, whereas neither fenfluramine nor metergoline had any effect on haloperidol-induced catalepsy. 8-OHDPAT strongly antagonised catalepsy induced by morphine or haloperidol. We conclude that serotonergic transmission plays a major role in effectuating morphine catalepsy but not in effectuating haloperidol catalepsy. The antagonistic effect of 8-OHDPAT suggests a secondary, modulating role for 5-HT1A receptor mediated events in both types of catalepsy.
authors.affiliation: Department CNS Pharmacology, Organon International B.V., Oss, The Netherlands.
authors.forename: C L
authors.initials: CL
authors.lastname: Broekkamp
authors.forename: S K
authors.initials: SK
authors.lastname: Oosterloo
authors.forename: H H
authors.initials: HH
authors.lastname: Berendsen
authors.forename: A M
authors.initials: AM
authors.lastname: van Delft
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced*; D004347:Drug Interactions; D005277:Fenfluramine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
chemical_list: D013764:Tetrahydronaphthalenes; D008711:Metergoline; D005277:Fenfluramine; D012701:Serotonin; D009020:Morphine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D006220:Haloperidol