title: The alpha-spectrin gene is on chromosome 1 in mouse and man.
abstract: By using alpha-spectrin cDNA clones of murine and human origin and somatic cell hybrids segregating either mouse or human chromosomes, the gene for alpha-spectrin has been mapped to chromosome 1 in both species. This assignment of the mouse alpha-spectrin gene to mouse chromosome 1 by DNA hybridization strengthens the previous identification of the alpha-spectrin locus in mouse with the sph locus, which previously was mapped by linkage analysis to mouse chromosome 1, distal to the Pep-3 locus. By in situ hybridization to human metaphase chromosomes, the human alpha-spectrin gene has been localized to 1q22-1q25; interestingly, the locus for a non-Rh-linked form of elliptocytosis has been provisionally mapped to band 1q2 by family linkage studies.
authors.forename: K
authors.initials: K
authors.lastname: Huebner
authors.forename: A P
authors.initials: AP
authors.lastname: Palumbo
authors.forename: M
authors.initials: M
authors.lastname: Isobe
authors.forename: C A
authors.initials: CA
authors.lastname: Kozak
authors.forename: S
authors.initials: S
authors.lastname: Monaco
authors.forename: G
authors.initials: G
authors.lastname: Rovera
authors.forename: C M
authors.initials: CM
authors.lastname: Croce
authors.forename: P J
authors.initials: PJ
authors.lastname: Curtis
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3; D006224:Cricetinae; D003412:Cricetulus; D004262:DNA Restriction Enzymes / Q000378:metabolism; D015247:Deoxyribonuclease HindIII; D006801:Humans; D007621:Karyotyping; D051379:Mice; D009693:Nucleic Acid Hybridization; D013049:Spectrin / Q000235:genetics*
chemical_list: D013049:Spectrin; D004262:DNA Restriction Enzymes; D015247:Deoxyribonuclease HindIII