HLA and antibiotic allergic skin eruption.
Chinese patients with cutaneous eruption due to antibiotics were found to be positively associated with HLA-BW46 (RR = 2.5; 95% confidence limit 1.2-4.9) and negatively associated with HLA-B40 (RR = 0.46; 95% confidence limit 0.22-0.98). The association with HLA-BW46 was even higher in patients with ampicillin sensitivity (RR = 3.5; 95% confidence limit 1.4-9.0).
Chan
S H
SH
WHO Immunology Centre, Faculty of Medicine, National University of Singapore.
Tan
T
T
Wee
G B
GB
Lim
A Y
AY
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002681:China / Q000208:ethnology; D003875:Drug Eruptions / Q000208:ethnology / Q000209:etiology* / Q000276:immunology; D015234:HLA-A Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D012846:Singapore
D000900:Anti-Bacterial Agents; D015234:HLA-A Antigens; D015235:HLA-B Antigens