Expression of the x-lor gene of human T-cell leukemia virus I in Escherichia coli.
The 3'-terminal regions of the human T-cell leukemia virus I (HTLV-I) and HTLV-II genomes encode a novel gene product. We showed that expression of this region fused to the beta-galactosidase gene in bacteria produces a protein recognized by adult T-cell leukemia-lymphoma patient sera. Rabbit antibodies raised against this protein specifically precipitated the 42-kilodalton x-lor gene protein from HTLV-I-infected cells.
Goh
W C
WC
Sodroski
J
J
Rosen
C
C
Haseltine
W
W
D004274:DNA, Recombinant; D017977:Deltaretrovirus / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics*; D005814:Genes, Viral; D005822:Genetic Vectors; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007945:Leukemia, Lymphoid / Q000276:immunology; D008223:Lymphoma / Q000276:immunology; D010957:Plasmids; D013601:T-Lymphocytes; D014764:Viral Proteins / Q000235:genetics* / Q000276:immunology
D004274:DNA, Recombinant; D007106:Immune Sera; D014764:Viral Proteins