title: Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.
abstract: Following the transfer into fertilized mouse eggs of recombinant genes composed of the upstream region of the rat insulin II gene linked to sequences coding for the large-T antigen of simian virus 40, large-T antigen is detected exclusively in the beta-cells of the endocrine pancreas of transgenic mice. The alpha- and delta-cells normally found in the islets of Langerhans are rare and disordered. Well-vascularized beta-cell tumours arise in mice harbouring and inheriting these hybrid oncogenes.
authors.forename: D
authors.initials: D
authors.lastname: Hanahan
mesh_terms: D007516:Adenoma, Islet Cell / Q000235:genetics* / Q000473:pathology; D000818:Animals; D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor / Q000235:genetics*; D002450:Cell Communication; D004274:DNA, Recombinant; D005786:Gene Expression Regulation; D007328:Insulin / Q000235:genetics*; D051379:Mice; D009857:Oncogenes; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D010641:Phenotype; D013539:Simian virus 40 / Q000235:genetics; D014018:Tissue Distribution; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor; D004274:DNA, Recombinant; D007328:Insulin; D014764:Viral Proteins