title: Severity of intestinal damage in gastroschisis: correlation with prenatal sonographic findings.
abstract: From 1982 to 1986, 26 abdominal wall defects were detected prenatally. Seventeen pregnancies culminated in live births with ultrasound correctly distinguishing between omphalocele and gastroschisis in all cases. In the 11 cases of gastroschisis diagnosed before birth, we attempted to correlate the clinical outcome with the size of the abdominal wall defect, sonographic appearance of the eviscerated bowel, and known time of exposure to amniotic fluid (gestational age at birth to gestational age at diagnosis). Neither the time of exposure to amniotic fluid (median duration of 14 weeks) nor the defect size could be correlated with eventual clinical outcome. The presence of small bowel dilatation and mural thickening on prenatal sonography (four patients) had a high correlation with severe intestinal damage and poor clinical outcome. The absence of these two sonographic findings (seven patients) was associated with mild intestinal changes and benign clinical course with no morbidity or mortality. We conclude that obstetric ultrasound cannot only accurately detect the presence and type of abdominal wall defect, but it also gives an indication of the severity of intestinal damage and subsequent clinical course in prenatally diagnosed cases of gastroschisis. Early delivery of the fetus with prenatally diagnosed gastroschisis should no longer be performed to limit exposure to amniotic fluid. Now that reliable sonographic criteria of severe intestinal damage have been defined, the decision to deliver early can be restricted to those fetuses with bowel dilatation and mural thickening.
authors.affiliation: Department of Surgery, University of California, San Francisco 94143.
authors.forename: S J
authors.initials: SJ
authors.lastname: Bond
authors.forename: M R
authors.initials: MR
authors.lastname: Harrison
authors.forename: R A
authors.initials: RA
authors.lastname: Filly
authors.forename: P W
authors.initials: PW
authors.lastname: Callen
authors.forename: R A
authors.initials: RA
authors.lastname: Anderson
authors.forename: M S
authors.initials: MS
authors.lastname: Golbus
mesh_terms: D000009:Abdominal Muscles / Q000002:abnormalities*; D003937:Diagnosis, Differential; D005260:Female; D006554:Hernia, Umbilical / Q000175:diagnosis*; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014463:Ultrasonography