[Augmentation of the expression of c-myc and c-fos oncogenes as a function of the mechanical activity of the isolated adult rat heart].
c-myc and c-fos oncogenes encode nuclear DNA binding proteins, and are involved in both growth regulation and differentiation. Using the molecular hybridization technique and DNA probes complementary to c-myc and c-fos mRNA, we report an increase in c-myc and c-fos expression level in the isolated beating adult rat heart with reference to the arrested isolated heart. This suggests a causal relationship between mechanical activity of the heart and c-myc and c-fos expression. It evidences for the first time a messenger between mechanical factor and adaptational changes in the phenotype which occurs at the beginning of cardiac hypertrophy.
Bauters
C
C
U 127, I.N.S.E.R.M., Hôpital Lariboisière, Paris.
Moalic
J M
JM
Bercovici
J
J
Mouas
C
C
Emanoil-Ravier
R
R
Schiaffino
S
S
Swynghedauw
B
B
D000818:Animals; D006332:Cardiomegaly / Q000235:genetics; D004247:DNA / Q000235:genetics; D005786:Gene Expression Regulation; D006321:Heart / Q000502:physiology*; D008297:Male; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains
D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger; D004247:DNA
Augmentation de l'expression des oncogènes c-myc et c-fos en fonction de l'activité mécanique du coeur isolé de rat adulte.