Calmodulin-activated calcium ATPase in bipolar illness.
Calmodulin-activated calcium ATPase is a transport enzyme which establishes the normal level of intracellular ionized calcium in most cells. We have determined values for three parameters of this enzyme: E-t, the concentration in the membrane; Vmax, the maximal velocity, and Ka, the binding affinity for calmodulin. We assayed these parameters in erythrocyte membranes from lithium carbonate-treated bipolar subjects and from normal controls. Bipolar subjects have significantly increased levels of E-t compared with normal controls.
Meltzer
H L
HL
New York State Psychiatric Institute, New York.
Kassir
S
S
Goodnick
P J
PJ
Fieve
R R
RR
Chrisomalis
L
L
Feliciano
M
M
Szypula
D
D
D000328:Adult; D000339:Affect / Q000187:drug effects; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000188:drug therapy / Q000201:enzymology*; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000097:blood*; D002147:Calmodulin / Q000097:blood*; D004789:Enzyme Activation; D004910:Erythrocyte Membrane / Q000201:enzymology; D005260:Female; D006801:Humans; D007700:Kinetics; D008094:Lithium / Q000494:pharmacology / Q000627:therapeutic use; D016651:Lithium Carbonate; D008297:Male; D008565:Membrane Proteins / Q000097:blood; D008875:Middle Aged; D008954:Models, Biological; D011485:Protein Binding
D002147:Calmodulin; D008565:Membrane Proteins; D016651:Lithium Carbonate; D008094:Lithium; D000252:Calcium-Transporting ATPases; D002118:Calcium