title: [ATPase activity of the heart microsomes, the regulation of calcium transport in the microsomes and the calmodulin content in experimental myocardial infarct].
abstract: Calmodulin and cAMP were demonstrated to have no stimulating effect on Ca2+ transport in the sarcoplasmic reticulum of the dog heart in experimental myocardial infarction as compared to that in the uninvolved myocardium (control). Introduction to the incubation medium of exogenous protein kinase in addition to calmodulin and cAMP provoked an approximately 35% increase in 45Ca accumulation in microsomes of the impaired myocardium as compared with the system containing no exogenous protein kinase. Under the same conditions, the control showed a 75% increase in 45Ca accumulation. A reduction in the activity of Ca2+-activated ATPase of the reticulum and translocation of calmodulin activity from the membrane fraction of cardiomyocytes to cytosol were recorded in myocardial infarction.
authors.forename: A E
authors.initials: AE
authors.lastname: Antipenko
authors.forename: E V
authors.initials: EV
authors.lastname: Sviderskaia
authors.forename: A N
authors.initials: AN
authors.lastname: Lyzlova
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D004285:Dogs; D008861:Microsomes / Q000378:metabolism*; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010766:Phosphorylation; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
chemical_list: D002147:Calmodulin; D000242:Cyclic AMP; D000251:Adenosine Triphosphatases; D002118:Calcium
vernacular_title: ATFaznaia aktivnost' mikrosom serdtsa, reguliatsiia transporta kal'tsiia v mikrosomakh i soderzhanie kal'modulina pri éksperimental'nom infarkte miokarda.