Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis.
The sera from A.SW/SnJ mice infected with Coxsackievirus B3 (CB3) were tested on normal mouse tissue by indirect immunofluorescence. Heart-reactive antibodies were found. Absorption studies with organ extracts showed some of these autoantibodies to be heart-specific. Additional antibodies were crossreactive with skeletal muscle and kidney. These findings suggest a role for autoimmunity in the pathogenesis of murine CB3-induced myocarditis. This study establishes an animal model for the study of the humoral autoimmune response in human viral myocarditis.
Wolfgram
L J
LJ
Beisel
K W
KW
Rose
N R
NR
D000042:Absorption; D000818:Animals; D000937:Antigen-Antibody Reactions; D001323:Autoantibodies / Q000032:analysis* / Q000096:biosynthesis; D003384:Coxsackievirus Infections / Q000276:immunology*; D029822:Enterovirus B, Human / Q000276:immunology; D005260:Female; D007668:Kidney / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009132:Muscles / Q000276:immunology; D009205:Myocarditis / Q000276:immunology*; D009206:Myocardium / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009928:Organ Specificity; D010215:Papio; D051381:Rats
D001323:Autoantibodies