Schistosoma mansoni and S. japonicum worm numbers in 129/J mice of two types and dominance of susceptibility in F1 hybrids.
In a study on the genetics of resistance to schistosomiasis in WEHI 129/J mice, susceptibility to either Schistosoma mansoni or Schistosoma japonicum was shown to be unequivocally dominant in F1 hybrid crosses between genetically resistant WEHI 129/J and susceptible BALB/c mice. The operation of only 1 or 2 genes in the expression of resistance to S. mansoni was suggested by backcross analysis. Thus, approximately 25% of (BALB/c x WEHI 129/J) F1 x WEHI 129/J mice were resistant to S. mansoni infection, whereas resistance was manifest in approximately 50% of WEHI 129/J mice. The data are consistent with resistance being controlled by 1 recessive gene having 50% penetrance. We also report that 129/J mice obtained directly from the Jackson Laboratories (Bar Harbor, Maine) (designated JAX 129/J), differ from locally bred WEHI 129/J in being entirely susceptible to S. mansoni infection. However, both WEHI 129/J and JAX 129/J are relatively resistant to S. japonicum infection.
Wright
M D
MD
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Tiu
W U
WU
Wood
S M
SM
Walker
J C
JC
Garcia
E G
EG
Mitchell
G F
GF
D000818:Animals; D003433:Crosses, Genetic; D004198:Disease Susceptibility; D005260:Female; D005808:Genes, Recessive; D007113:Immunity, Innate; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012549:Schistosoma japonicum / Q000254:growth & development / Q000276:immunology; D012550:Schistosoma mansoni / Q000254:growth & development / Q000276:immunology; D012554:Schistosomiasis japonica / Q000235:genetics / Q000276:immunology* / Q000469:parasitology; D012555:Schistosomiasis mansoni / Q000235:genetics / Q000276:immunology* / Q000469:parasitology; D013047:Specific Pathogen-Free Organisms