Interaction at a distance between lambda repressors disrupts gene activation.
The lambda repressor is an activator as well as a repressor of transcription. The activation function is blocked by interaction with another lambda repressor molecule bound upstream on the same DNA molecule. This example of negative control at a distance involves formation of a DNA loop.
Hochschild
A
A
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
Ptashne
M
M
D010582:Bacteriophage lambda / Q000235:genetics*; D005786:Gene Expression Regulation; D009154:Mutation; D009876:Operon; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D015533:Transcriptional Activation
D012097:Repressor Proteins; D014157:Transcription Factors