Studies on the mechanism of action of halogenated aromatic hydrocarbons.
The halogenated aromatic hydrocarbons (dibenzo-p-dioxins, dibenzofurans, azo[xy]benzenes and biphenyls), a group of toxic chemicals in the environment, (a) are approximate isostereomers; (b) produce a similar pattern of biologic responses and (c) appear to act by a common mechanism. These compounds reversibly bind to a soluble receptor protein to initiate a coordinate gene expression, analogous to the action of steroid hormones. This receptor controls two distinct and dissociable pleiotropic responses: (a) the induction of microsomal monooxygenase activity and other drug metabolizing enzymes and (b) morphologic (i.e. toxic) changes, many of which involve altered cell proliferation and/or differentiation in epithelial tissues.
Poland
A
A
Knutson
J
J
Glover
E
E
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis; D002417:Cattle; D002645:Chickens; D006224:Cricetinae; D004790:Enzyme Induction; D006168:Guinea Pigs; D000882:Haplorhini; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000378:metabolism / Q000633:toxicity*; D007700:Kinetics; D008748:Methylcholanthrene / Q000378:metabolism / Q000633:toxicity; D051379:Mice; D008812:Mice, Hairless; D008862:Microsomes, Liver / Q000201:enzymology; D000072317:Polychlorinated Dibenzodioxins / Q000378:metabolism / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug / Q000187:drug effects
D006846:Hydrocarbons, Halogenated; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug; D008748:Methylcholanthrene; D001189:Aryl Hydrocarbon Hydroxylases