title: Parathion-provoked lethality in rats is reduced by diethyldithiocarbamate.
abstract: Intoxication of male rats with 5 mg/kg parathion reduces survival to 15%. Diethyldithiocarbamate (DDC), known to inhibit mixed-function oxidase activity, has no effect on survival rate when this compound is used in a dosage of 300 mg/kg 45 min before or 10 min after parathion intoxication. However, when DDC and parathion are administered simultaneously, the rate of survival rises to 53%.
authors.forename: J
authors.initials: J
authors.lastname: Homann
authors.forename: S
authors.initials: S
authors.lastname: Schneider
authors.forename: K J
authors.initials: KJ
authors.lastname: Matthes
mesh_terms: D000818:Animals; D004050:Ditiocarb / Q000494:pharmacology*; D007928:Lethal Dose 50; D008297:Male; D010278:Parathion / Q000037:antagonists & inhibitors / Q000633:toxicity*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013859:Thiocarbamates / Q000494:pharmacology*
chemical_list: D013859:Thiocarbamates; D010278:Parathion; D004050:Ditiocarb; D010634:Phenobarbital