title: Ethinylestradiol and desogestrel, alone or in combination with two doses of estriol. Effects on plasma proteins.
abstract: Nineteen fertile women were treated with three differently composed oral contraceptives in a cross-over study and were randomly allocated to begin with one of the three preparations. The tablets contained 0.030 mg ethinylestradiol +0.15 mg desogestrel alone (A) or in combination with either 0.5 mg estriol (B) or 2 mg estriol (C). After two treatment cycles on each preparation, blood samples were obtained and analysed for ceruloplasmin, SHBG, prealbumin, transcortin and thyroxine-binding globulin. No differences were found in the induction of liver protein synthesis. It was concluded that the addition of estriol in doses of 0.5 or 2 mg did not influence the effects induced by ethinylestradiol.
authors.affiliation: Department of Obstetrics and Gynecology, University of Gothenburg, East Hospital, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Cullberg
authors.forename: L A
authors.initials: LA
authors.lastname: Mattsson
mesh_terms: D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000032:analysis*; D002570:Ceruloplasmin / Q000032:analysis; D002986:Clinical Trials as Topic; D003276:Contraceptives, Oral / Q000008:administration & dosage*; D003279:Contraceptives, Oral, Sequential / Q000008:administration & dosage*; D017135:Desogestrel; D004964:Estriol / Q000008:administration & dosage*; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D009652:Norpregnenes / Q000008:administration & dosage*; D011228:Prealbumin / Q000032:analysis; D011897:Random Allocation; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013975:Thyroxine-Binding Proteins / Q000032:analysis; D014156:Transcortin / Q000032:analysis
chemical_list: D001798:Blood Proteins; D003276:Contraceptives, Oral; D003279:Contraceptives, Oral, Sequential; D009652:Norpregnenes; D011228:Prealbumin; D012738:Sex Hormone-Binding Globulin; D013975:Thyroxine-Binding Proteins; D004997:Ethinyl Estradiol; D017135:Desogestrel; D014156:Transcortin; D002570:Ceruloplasmin; D004964:Estriol