title: Clinical, serologic, and immunologic effects of human leukocyte interferon in HBsAg-positive primary hepatocellular carcinoma.
abstract: Five patients with hepatitis B surface antigen (HBsAg) positive chronic hepatitis and histologically confirmed primary hepatocellular carcinoma (PHC) were treated with 3 X 10(6) units/day of partially purified human leukocyte interferon intramuscularly for 2 consecutive months. During interferon therapy, one patient had stable disease, while the remaining four patients had progressive disease. Following interferon therapy no changes were noted in the hepatitis B viral markers or in serum alphafetoprotein levels. Data on the effects of human leukocyte interferon on lymphocyte subpopulations and on the cytotoxic activity of peripheral blood mononuclear cells against a hepatitis B surface antigen expressing primary hepatocellular carcinoma cell line are presented.
authors.forename: P V
authors.initials: PV
authors.lastname: Nair
authors.forename: M J
authors.initials: MJ
authors.lastname: Tong
authors.forename: R
authors.initials: R
authors.lastname: Kempf
authors.forename: R
authors.initials: R
authors.lastname: Co
authors.forename: S D
authors.initials: SD
authors.lastname: Lee
authors.forename: C L
authors.initials: CL
authors.lastname: Venturi
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000276:immunology / Q000628:therapy*; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic; D006509:Hepatitis B / Q000150:complications; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects / Q000627:therapeutic use*; D007958:Leukocyte Count; D008113:Liver Neoplasms / Q000150:complications / Q000276:immunology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
chemical_list: D006514:Hepatitis B Surface Antigens; D007370:Interferon Type I