Epstein-Barr virus transformation of human B lymphocytes despite inhibition of viral polymerase.
Epstein-Barr virus transformed human lymphocytes despite the presence of up to 500 microM acyclovir [9-(2-hydroxyethoxymethyl)guanine], a viral DNA polymerase inhibitor. The transformed cells contained multiple Epstein-Barr virus genome copy numbers. Functional viral DNA polymerase is probably not required for cell transformation and the initial amplification of the viral genome.
Sixbey
J W
JW
Pagano
J S
JS
D000212:Acyclovir / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000382:microbiology*; D002472:Cell Transformation, Viral / Q000187:drug effects*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D007700:Kinetics; D019384:Nucleic Acid Synthesis Inhibitors; D011247:Pregnancy; D014470:Umbilical Cord
D004279:DNA, Viral; D019384:Nucleic Acid Synthesis Inhibitors; D000212:Acyclovir