Acute renal failure, skin rash, and eosinophilia associated with aztreonam.
A case of acute renal failure associated with aztreonam therapy is reported. A man, age 70, with infections due to Klebsiella pneumoniae and Enterobacter cloaca was treated for 9 days with aztreonam and presented with a generalized maculopapular rash, fever, eosinophilia, worsening renal function and increased IgE levels and eosinophiluria. Aztreonam was then discontinued and the patient was treated with supportive measures and steroids and his renal failure reversed over the course of 5 days. This appears to be one of the first cases of acute renal failure associated with aztreonam.
Pazmiño
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Nephrology and Hypertension Center, Texas Tech University Health Science Center School of Medicine, El Paso.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D001398:Aztreonam / Q000009:adverse effects*; D003131:Combined Modality Therapy; D003875:Drug Eruptions / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000628:therapy; D008297:Male; D011014:Pneumonia / Q000188:drug therapy / Q000209:etiology
D001398:Aztreonam