Prenatal chlordiazepoxide effects on metrazol seizures and benzodiazepine receptors density in adult albino rats.
Adult offsprings of rats treated with daily injection of chlordiazepoxide (10 mg/kg, i.p.) during pregnancy showed a significant decrease in benzodiazepine receptors in the cortex and the cerebellum without apparent changes in receptor affinity. A reduced susceptibility to metrazol-induced epileptogenesis paralleled this change. These findings are discussed in relation to the differential vulnerability of various types of benzodiazepine receptors.
Gavish
M
M
Avnimelech-Gigus
N
N
Feldon
J
J
Myslobodsky
M
M
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000196:embryology / Q000378:metabolism; D002531:Cerebellum / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004351:Drug Resistance; D005260:Female; D005445:Flunitrazepam / Q000378:metabolism; D010433:Pentylenetetrazole; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects*; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
D011963:Receptors, GABA-A; D005445:Flunitrazepam; D002707:Chlordiazepoxide; D010433:Pentylenetetrazole