title: Human atrial natriuretic polypeptide in plasma of patients with anorexia nervosa.
abstract: To examine the effects of chronic dehydration and starvation on plasma levels of human atrial natriuretic polypeptide (hANP) in human subjects, the basal level and saline-induced rise of plasma hANP in 7 patients with anorexia nervosa were compared with those in age-matched healthy subjects. The unstimulated level of plasma hANP was markedly high in the patients with anorexia nervosa (patients vs. control; 55.4 +/- 9.0 pg/ml vs. 11.4 +/- 6.1 pg/ml, P less than 0.01). However, no significant increase of plasma hANP in the anorectic patients was observed in response to saline-infusion, while a 3-fold increase over the basal level of plasma hANP was noted in the saline-infused normal young subjects. These results show that hANP may be secreted to an inadequate extent, hence the release would be resistant to volume-loading. The pathophysiological meaning of such a high plasma concentrations of hANP in anorexia nervosa is the subject of ongoing studies.
authors.affiliation: Third Department of Internal Medicine, Kyushu University, Faculty of Medicine, Fukuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ohashi
authors.forename: N
authors.initials: N
authors.lastname: Fujio
authors.forename: H
authors.initials: H
authors.lastname: Nawata
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: S
authors.initials: S
authors.lastname: Matsubayashi
authors.forename: H
authors.initials: H
authors.lastname: Tamai
authors.forename: H
authors.initials: H
authors.lastname: Matsuo
authors.forename: H
authors.initials: H
authors.lastname: Ibayashi
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood*; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002850:Chromatography, Gel; D005260:Female; D006801:Humans; D008297:Male; D011863:Radioimmunoassay
chemical_list: D015415:Biomarkers; D009320:Atrial Natriuretic Factor