Calcitonin gene-related peptide(CGRP) stimulates the release of atrial natriuretic peptide(ANP) from isolated rat atria.
The effect of calcitonin gene-related peptide(CGRP) on the release of atrial natriuretic peptide(ANP) was studied in spontaneously beating, isolated rat atria. CGRP stimulated the ANP release in a dose-dependent manner. When the atria were incubated with a combination of phentolamine, propranolol, and atropine, these antagonists blocked neither the rise in ANP release nor the positive chronotropic and inotropic effects of CGRP. Therefore, we conclude that CGRP stimulates ANP release as well as cardiac contractility independently of adrenergic and cholinergic receptors.
Yamamoto
A
A
Department of Pharmacology, Kagawa Medical School, Japan.
Kimura
S
S
Hasui
K
K
Fujisawa
Y
Y
Tamaki
T
T
Fukui
K
K
Iwao
H
H
Abe
Y
Y
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D001285:Atropine / Q000494:pharmacology; D015740:Calcitonin Gene-Related Peptide; D006321:Heart / Q000187:drug effects; D006325:Heart Atria / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009479:Neuropeptides / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
D009479:Neuropeptides; D001285:Atropine; D009320:Atrial Natriuretic Factor; D011433:Propranolol; D015740:Calcitonin Gene-Related Peptide; D010646:Phentolamine