Clinical studies on cell-mediated immunity in patients with urinary bladder carcinoma. Depression of cell-mediated immunity by adherent cells.
Lymphocyte blastogenesis by stimulation with phytohemagglutinin was compared in 10 control subjects and 20 patients with bladder cancer. Blastogenesis was measured by the incorporation of 3H-thymidine into lymphocytes using microplate assay. As a result, blastogenesis was significantly decreased in high stage patients compared to control subjects and low stage patients. When the nylon wool adherent cells were removed, lymphocyte blastogenesis was increased in high stage patients, while it was decreased in control subjects and low stage patients. This study provides evidence that in most bladder cancer patients with in vitro immunodepression, adherent suppressor cells are detectable, and that these cells may mediate the noted immunodepression.
Ikemoto
S
S
Department of Urology, Osaka City University Medical School, Japan.
Kishimoto
T
T
Nishio
S
S
Mori
K
K
Maekawa
M
M
D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000276:immunology*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008213:Lymphocyte Activation; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D001749:Urinary Bladder Neoplasms / Q000276:immunology*
D007213:Indomethacin