title: Identification of enzymatic activities which process protein bound mono(ADP-ribose).
abstract: Enzymatic activities have been identified in extracts of cultured mouse cells which catalyze the removal of intact mono(ADP-ribosyl) residues linked to proteins at arginine. Activities that sequentially remove AMP and ribose 5-phosphate have also been identified. These results suggest that mono(ADP-ribosylation) of proteins is a reversible post translational modification.
authors.forename: K P
authors.initials: KP
authors.lastname: Smith
authors.forename: R C
authors.initials: RC
authors.lastname: Benjamin
authors.forename: J
authors.initials: J
authors.lastname: Moss
authors.forename: M K
authors.initials: MK
authors.lastname: Jacobson
mesh_terms: D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000818:Animals; D002472:Cell Transformation, Viral; D002854:Chromatography, Paper; D005347:Fibroblasts / Q000201:enzymology*; D006657:Histones / Q000378:metabolism; D008274:Magnesium / Q000494:pharmacology; D015636:Magnesium Chloride; D051379:Mice; D009702:Nucleoside Diphosphate Sugars / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D013539:Simian virus 40
chemical_list: D006657:Histones; D009702:Nucleoside Diphosphate Sugars; D015636:Magnesium Chloride; D000246:Adenosine Diphosphate Ribose; D008274:Magnesium