[General pharmacological studies on a bronchodilator, oxitropium bromide (Ba 253)].
The effects of oxitropium bromide (Ba 253) on respiratory, cardiovascular, digestive and urogenital systems were studied. Ba 253 increased heart rate in anesthetized cats at low doses (0.1-0.3 mg/kg, i.v.) and decreased blood pressure in dogs and cats at high dose (3 mg/kg, i.v.). Aerosol inhalation of a high concentration of Ba 253, however, did not influence the heart rate. Ba 253 enhanced the isoproterenol-induced inotropic action and vasodilation. Intestinal transport of mice were inhibited by Ba 253 (s.c.), but not inhibited by oral administration. Ba 253 (1-30 mg/kg, i.v.) enhanced the motility of rat uterus in vivo, but inhalation of the Ba 253 aerosol did not have any affect. Ba 253 had no effects on vasoconstriction, spontaneous motility of the ileum, bile secretion, urinary excretion and spontaneous motility of the urinary bladder. These results indicate that intravenous or subcutaneous administration of Ba 253 decreased blood pressure, enhanced uterus motility and inhibited intestinal transport, but the inhalation or oral administration, even at high doses, has no effects on the cardiovascular system and uterine motility.
Kitagawa
H
H
Department of Pharmacology, Kawanishi Pharma Research Institute, Hyogo, Japan.
Takeda
F
F
Hayashi
T
T
Izumita
M
M
Kohei
H
H
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects; D002415:Cats; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects; D009241:Ipratropium / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012602:Scopolamine Derivatives / Q000008:administration & dosage / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects
D001993:Bronchodilator Agents; D010276:Parasympatholytics; D012602:Scopolamine Derivatives; D001285:Atropine; C017590:oxitropium; D009241:Ipratropium