Adduct formation is involved in radiosensitization, mediated by cytochrome c, of phi X174 DNA by misonidazole.
Radiosensitization by misonidazole of biologically active phi X174 DNA, mediated by cytochrome c, is most probably at least partly due to formation of an adduct between sensitizer and DNA, which can be removed from the DNA by a mild alkaline treatment thereby restoring the activity of the DNA.
Lafleur
M V
MV
Plijmackers-Westmijze
E J
EJ
Loman
A C
AC
Loman
H
H
D010584:Bacteriophage phi X 174; D003574:Cytochrome c Group / Q000494:pharmacology*; D004277:DNA, Single-Stranded / Q000528:radiation effects; D004279:DNA, Viral / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D008920:Misonidazole / Q000494:pharmacology*; D009593:Nitroimidazoles / Q000494:pharmacology*; D011831:Radiation Genetics; D011836:Radiation Tolerance
D003574:Cytochrome c Group; D004277:DNA, Single-Stranded; D004279:DNA, Viral; D009593:Nitroimidazoles; D008920:Misonidazole