title: Glucosteroid (GS)-dependent immunomodulation of immunoglobulin biosynthesis in vitro. III. Effect of GS on helper and suppressor cells' Ig production in vitro.
abstract: GS inhibit both the function of spontaneously occurring helper and suppressor T cells, but the latter activity appears to be more sensitive. The process of induction of suppressor T cells by Concanavalin A is partly steroid-sensitive. Active ConA-induced suppressors appear to be more resistant to GS.
authors.affiliation: Department of Experimental Immunosuppression, Medical Academy, Warsaw.
authors.forename: G
authors.initials: G
authors.lastname: Korczak-Kowalska
authors.forename: A
authors.initials: A
authors.lastname: Górski
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000502:physiology*; D002478:Cells, Cultured; D003208:Concanavalin A; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000187:drug effects; D011239:Prednisolone / Q000494:pharmacology / Q000502:physiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism
chemical_list: D000276:Adjuvants, Immunologic; D007136:Immunoglobulins; D003208:Concanavalin A; D011239:Prednisolone