[Teratogenic effect of pyrimethamine in the rat. In vivo prevention by calcium folinate].
In vivo prevention of malformations induced by pyrimethamine was studied in the rat. The administration of calcium folinate had an almost complete antiteratogenic effect on external, visceral and skeletal malformations, provided that the vitamin was administered together with the pyrimethamine and that the treatment was continued for the following two days.
Horvath
C
C
Laboratoire de Physiopathologie du Développement, Université P. et M. Curie, Paris.
Compagnon
A
A
Petter
C
C
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control*; D000818:Animals; D004338:Drug Combinations; D005260:Female; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use*; D011739:Pyrimethamine / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D004338:Drug Combinations; D002955:Leucovorin; D011739:Pyrimethamine
Effet tératogène de la pyriméthamine chez le rat. Prévention in vivo par le folinate de calcium.