title: Effect of supplementary vaccination in healthy non-responders to hepatitis B vaccination.
abstract: Among 831 healthy hospital employees vaccinated in accordance with a standard hepatitis B vaccination schedule (three doses of 20 micrograms i.m.), we found 38 (4.6%) hypo- and non-responders with an anti-HBs level less than 10 IU/l. Additional vaccinations with up to three standard doses of hepatitis B vaccine were given to 26 individuals, nine of whom developed anti-HBS titers higher than 10 IU/l after one additional vaccination. Two subjects received no further vaccination. The remaining group of 15 persons were given 2 more injections. After six vaccinations, nine subjects had an anti-HBs response of more than 10 IU/l, while six still had no detectable anti-HBs. In conclusion, supplementary vaccination of healthy hypo- and non-responders after standard hepatitis B vaccination induced an anti-HBs titer greater than 10 IU/l in 38% after one and in 75% after three additional doses of 20 micrograms of hepatitis B vaccine given intramuscularly.
authors.affiliation: Department of Gastroenterology, University of Utrecht, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Wismans
authors.forename: J
authors.initials: J
authors.lastname: van Hattum
authors.forename: T
authors.initials: T
authors.lastname: Stelling
authors.forename: J
authors.initials: J
authors.lastname: Poel
authors.forename: G C
authors.initials: GC
authors.lastname: de Gast
mesh_terms: D006509:Hepatitis B / Q000517:prevention & control*; D017325:Hepatitis B Vaccines; D006801:Humans; D009784:Occupational Diseases / Q000517:prevention & control*; D010564:Personnel, Hospital; D014611:Vaccination; D014761:Viral Hepatitis Vaccines
chemical_list: D017325:Hepatitis B Vaccines; D014761:Viral Hepatitis Vaccines