title: The hydrolysis of ATP that accompanies actin polymerization is essentially irreversible.
abstract: The hydrolysis of ATP that accompanies the polymerization of actin occurs on the F-actin subsequent to the addition of the G-ATP-actin subunit to the elongating filament. We now show that this ATP hydrolysis is essentially irreversible. Thus, a large decrease in free energy occurs at the cleavage step, F-ATP-actin----F-ADP-Pi-actin.
authors.affiliation: Laboratoire d'Enzymologie, CNRS, Gif-sur-Yvette, France.
authors.forename: M F
authors.initials: MF
authors.lastname: Carlier
authors.forename: D
authors.initials: D
authors.lastname: Pantaloni
authors.forename: J A
authors.initials: JA
authors.lastname: Evans
authors.forename: P K
authors.initials: PK
authors.lastname: Lambooy
authors.forename: E D
authors.initials: ED
authors.lastname: Korn
authors.forename: M R
authors.initials: MR
authors.lastname: Webb
mesh_terms: D000199:Actins / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D006868:Hydrolysis; D010710:Phosphates / Q000378:metabolism; D011108:Polymers; D011817:Rabbits
chemical_list: D000199:Actins; D010710:Phosphates; D011108:Polymers; D000255:Adenosine Triphosphate; D000252:Calcium-Transporting ATPases