title: Alterations of inhibitory processes in the dentate gyrus following kindling-induced epilepsy.
abstract: In vitro hippocampal slices were prepared from control and commissural-kindled rats and the inhibitory processes of the dentate granule cells were assessed using paired perforant path stimulation. An early (20 ms) Cl(-)-dependent and a late (200 ms-8 s) Cl(-)-independent inhibition were shown to be present in the dentate. Enhancement of the late Cl(-)-insensitive inhibition was observed following the establishment of commissural kindling and persisted for periods of up to eight weeks following the last seizure.
authors.forename: M W
authors.initials: MW
authors.lastname: Oliver
authors.forename: J J
authors.initials: JJ
authors.lastname: Miller
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000502:physiology; D002712:Chlorides / Q000502:physiology; D004558:Electric Stimulation; D004827:Epilepsy / Q000503:physiopathology*; D006624:Hippocampus / Q000503:physiopathology*; D066298:In Vitro Techniques; D007696:Kindling, Neurologic; D008297:Male; D009433:Neural Inhibition; D009434:Neural Pathways / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D002135:Calcium-Binding Proteins; D002712:Chlorides; D005680:gamma-Aminobutyric Acid