Is the urinary excretion of prostaglandin E in man dependent on urine pH?
The relationship between urine pH, modified by the oral administration of either ammonium chloride or sodium bicarbonate, and the urinary excretion of prostaglandin E (PGE) was studied in healthy female subjects. The urinary concentration of PGE, normally constant in man, was significantly higher (P less than 0.02) in alkaline than in acid urine. pH-dependent metabolism and flow-dependent excretion were identified as two factors liable to obscure the demonstration of the pH-dependency of the urinary excretion rate of PGE in man.
Haylor
J
J
Toner
J M
JM
Jackson
P R
PR
Ramsay
L E
LE
Lote
C J
CJ
D000328:Adult; D000643:Ammonium Chloride / Q000494:pharmacology; D001639:Bicarbonates / Q000494:pharmacology; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009994:Osmolar Concentration; D011458:Prostaglandins E / Q000652:urine*; D017693:Sodium Bicarbonate
D001639:Bicarbonates; D011458:Prostaglandins E; D000643:Ammonium Chloride; D017693:Sodium Bicarbonate