[Effect of bacterial DNA gyrase inhibitors on the radiosensitivity of thymocytes and on the utilization of exogenous adenine in these cells].
It was established that the postirradiation changes in incorporation of 14C-adenine into acid-soluble and acid-insoluble fractions of thymocytes reflected cell death. When added after irradiation, nalidixic and oxolinic acids exerted a radioprotective action. The effect was absent after single washing of thymocytes incubated with these compounds for 60 min before or after irradiation. Both substances inhibited utilization of 14C-adenine and incorporation thereof into the acid-insoluble fraction of nonirradiated thymocytes and did not influence the viability of cells.
Kuznetsova
E V
EV
Koshcheenko
N I
NI
Filippovich
I V
IV
D000225:Adenine / Q000378:metabolism*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002588:Cesium Radioisotopes; D004269:DNA, Bacterial; D005720:Gamma Rays; D066298:In Vitro Techniques; D008297:Male; D009268:Nalidixic Acid / Q000494:pharmacology; D010093:Oxolinic Acid / Q000494:pharmacology; D011836:Radiation Tolerance; D051381:Rats; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D059005:Topoisomerase II Inhibitors
D002588:Cesium Radioisotopes; D004269:DNA, Bacterial; D059005:Topoisomerase II Inhibitors; D009268:Nalidixic Acid; D000225:Adenine; D010093:Oxolinic Acid
Vliianie ingibitorov bakterial'noĭ DNK-girazy na radiochuvstvitel'nost' timotsitov i utiliaztsiiu ékzogennogo adenina v étikh kletkakh.