Loss of sensitivity to ACTH of adrenocortical cells isolated from maturing domestic fowl.
Maturation of domestic fowl corticosteroidogenesis was evaluated using purified adrenocortical cells. Basal corticosterone production decreased steadily from 2 days to 26 weeks after hatching. However, maximally stimulated corticosterone production was not changed. In contrast, the half-maximal steroidogenic concentrations (ED50 values or effective doses for 50% maximal effect) of ACTH analogs increased approximately 40 times by 26 weeks, but the ED50 values of 8-bromo-cyclic AMP and pregnenolone were not changed. This suggests that adrenocortical cell sensitivity to ACTH decreases with maturation of the domestic fowl.
Carsia
R V
RV
Scanes
C G
CG
Malamed
S
S
D000302:Adrenal Cortex / Q000187:drug effects / Q000502:physiology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000375:Aging; D000818:Animals; D002478:Cells, Cultured; D003345:Corticosterone / Q000096:biosynthesis; D008297:Male; D011200:Poultry / Q000502:physiology
D000324:Adrenocorticotropic Hormone; D003345:Corticosterone