Genetics of susceptibility to 6-aminonicotinamide-induced cleft palate in the mouse: studies in congenic and recombinant inbred strains.
In a search for genetic differences in susceptibility to cleft palate, congenic and recombinant inbred strains of mice were treated with 6-aminonicotinamide or control injections. Of six loci tested, only the chromosome segment marked by N-acetyl transferase was found to affect susceptibility to 6-aminonicotinamide-induced cleft palate. This chromosome segment is known to affect glucocorticoid-induced cleft palate and phenytoin-induced cleft lip with or without cleft palate in these strains of mice.
Karolyi
J
J
Department of Human Genetics, University of Michigan, Ann Arbor 49109-0618.
Erickson
R P
RP
Liu
S
S
D015120:6-Aminonicotinamide / Q000009:adverse effects*; D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced*; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D009536:Niacinamide / Q000031:analogs & derivatives*; D011247:Pregnancy; D011995:Recombination, Genetic / Q000187:drug effects
D009536:Niacinamide; D015120:6-Aminonicotinamide