title: Immunoglobulin subclasses of antibodies to human T-cell leukemia/lymphoma virus I-associated antigens in acquired immune deficiency syndrome and lymphadenopathy syndrome.
abstract: Immunoglobulin G (IgG) and IgM antibodies to human T-cell leukemia/lymphoma virus-I (HTLV-I)-associated membrane antigens (HTLV-I-MA) were assayed by indirect cytospin immunofluorescence, and IgG and IgM antibodies to purified HTLV-I were assayed by enzyme-linked immunosorbent assay in sera from 119 immunologically well-characterized promiscuous male homosexuals in The Netherlands, of whom 9 suffered from acquired immune deficiency syndrome (AIDS), 18 suffered from lymphadenopathy syndrome (LAS), and 5 suffered from gay bowel syndrome. Antibodies to HTLV-I-MA were present in four of nine AIDS patients, including one patient with antibodies to purified HTLV-I. Antibodies to HTLV-I-MA were present in 6 of 18 LAS patients, including 3 patients with antibodies to purified HTLV-I. Of five patients with gay bowel syndrome, one had IgG and IgM antibodies to HTLV-I-MA. Of the four HTLV-I seropositive AIDS patients, two had IgG and IgM antibodies to HTLV-I or HTLV-I-MA, one had only IgG antibodies, and one had only IgM antibodies. Of the six HTLV-I seropositive LAS patients, four had IgG and IgM antibodies to HTLV-I or HTLV-I-MA, and two had only IgM antibodies. In the sera from 27 healthy homosexuals with and 60 without T-cell subset imbalances, no antibodies to HTLV-I or HTLV-I-MA were detected.
authors.forename: J
authors.initials: J
authors.lastname: Goudsmit
authors.forename: F
authors.initials: F
authors.lastname: Miedema
authors.forename: R J
authors.initials: RJ
authors.lastname: Wijngaarden-du Bois
authors.forename: M T
authors.initials: MT
authors.lastname: Roos
authors.forename: P T
authors.initials: PT
authors.lastname: Schellekens
authors.forename: R A
authors.initials: RA
authors.lastname: Coutinho
authors.forename: J
authors.initials: J
authors.lastname: van der Noordaa
authors.forename: C J
authors.initials: CJ
authors.lastname: Melief
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000382:microbiology*; D000906:Antibodies; D000956:Antigens, Viral / Q000032:analysis* / Q000276:immunology*; D017977:Deltaretrovirus / Q000276:immunology*; D003967:Diarrhea / Q000276:immunology / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D015488:HIV Antigens; D006716:Homosexuality; D006801:Humans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000382:microbiology*; D008297:Male; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000906:Antibodies; D000956:Antigens, Viral; D015488:HIV Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M