[Reactivation of gamma-ray irradiated parvovirus H-1 in cells of patients with ataxia telangiectasia and Huntington's chorea].
Parvovirus H-1 was used to probe the cellular radiosensitivity of two human degeneration syndromes AT and HC. No difference in the survival of gamma irradiated H-1 was detected between skin fibroblasts from such patients and from a normal individual. However, AT and normal cells were distinguished by the fact that the reactivation of irradiated H-1 could be increased by UV or X-irradiation of the latter but not of the former cells.
Hilgers
G
G
Deleys-Hertoghs
J
J
Cornelis
J
J
Klein
B
B
Rommelaere
J
J
D000818:Animals; D001260:Ataxia Telangiectasia / Q000473:pathology*; D002460:Cell Line; D002472:Cell Transformation, Viral; D005347:Fibroblasts / Q000382:microbiology / Q000528:radiation effects; D005720:Gamma Rays; D006801:Humans; D006816:Huntington Disease / Q000473:pathology*; D010321:Parvoviridae / Q000528:radiation effects*; D013539:Simian virus 40; D012867:Skin / Q000382:microbiology / Q000528:radiation effects; D014775:Virus Activation
Réactivation du Parvovirus H-1 irradié aux Rayons gamma dans les cellules de patients atteints d'ataxia telangiectasia et de la chorée de Huntington.