Penetrating duodenal ulcer from hepatic artery chemotherapy infusion catheter. Successful conservative medical management.
A 45-year-old woman receiving continuous infusions of 5-fluoro-2'-deoxy-uridine into the hepatic artery through a surgically implanted intraarterial catheter for hepatic metastases from adenocarcinoma of the colon, developed acute epigastric pain and anemia. Endoscopy demonstrated a duodenal ulcer with a portion of the catheter visible in the crater. Conservative management with sucralfate and ranitidine allowed endoscopically proven healing of the penetrating ulcer with subsequent successful reuse of the catheter.
Hutchins
L F
LF
Department of Hematology & Oncology, University of Arkansas for Medical Science, Little Rock 72205.
Webb
R T
RT
Ortego
T J
TJ
Lang
N P
NP
Navab
F
F
D000230:Adenocarcinoma / Q000188:drug therapy; D002408:Catheters, Indwelling / Q000009:adverse effects; D004381:Duodenal Ulcer / Q000209:etiology*; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000009:adverse effects* / Q000295:instrumentation; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008875:Middle Aged; D010439:Peptic Ulcer Perforation / Q000209:etiology*
D005467:Floxuridine