title: Phytohemagglutinin activation of the transcription of the bovine leukemia virus genome requires de novo protein synthesis.
abstract: Addition of supramitogenic doses of phytohemagglutinin (PHA) to short-term cultures of neoplastic or nonneoplastic lymphocytes infected with bovine leukemia virus increased the synthesis of the major core virion antigen (p25) by 5- to 10-fold. Such stimulation was not due to the mitogenic effect of PHA or to a generalized increase in cellular RNA or protein synthesis but rather to enhanced transcription of the viral genome by a PHA-induced protein.
authors.forename: R
authors.initials: R
authors.lastname: Chatterjee
authors.forename: P
authors.initials: P
authors.lastname: Gupta
authors.forename: S V
authors.initials: SV
authors.lastname: Kashmiri
authors.forename: J F
authors.initials: JF
authors.lastname: Ferrer
mesh_terms: D001483:Base Sequence; D005814:Genes, Viral; D001909:Leukemia Virus, Bovine / Q000235:genetics*; D010835:Phytohemagglutinins / Q000494:pharmacology*; D012190:Retroviridae / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects*; D014764:Viral Proteins / Q000096:biosynthesis*
chemical_list: D010835:Phytohemagglutinins; D014764:Viral Proteins