[Protective action of nicotinamide and pyridoxine on the initiation stage of carcinogenesis induced in mice by procarbazine].
It is shown that at the initiating stage of procarbazine carcinogenesis in F1 female mice the parenteral administration of nicotinamide or pyridoxine results in a significant decrease in the lung adenoma rate from 77% to 18 or 46%, respectively. Pyridoxal, pyridoxal-5'-phosphate and L-penicillamine did not influence the lung adenoma frequency.
Nikonova
T V
TV
Draudin-Krylenko
V A
VA
Bukin
Iu V
IuV
Turusov
V S
VS
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D009536:Niacinamide / Q000627:therapeutic use*; D010396:Penicillamine / Q000627:therapeutic use; D011344:Procarbazine / Q000633:toxicity*; D011736:Pyridoxine / Q000627:therapeutic use*
D009536:Niacinamide; D011344:Procarbazine; D010396:Penicillamine; D011736:Pyridoxine
Zashchitnoe deĭstvie nikotinamida i piridoksina na stadii initsiatsii kantserogeneza, vyzvvaemogo u mysheĭ prokarbazinom.