P1-purinoceptors mediate relaxation of the bovine bronchial artery.
Adenosine 5'-triphosphate (ATP), adenosine 5'-diphosphate (ADP), adenosine 5'-monophosphate (AMP) and adenosine all relaxed the bronchial artery. All four purines tested were more efficacious than isoproterenol. Dipyridamole (10(-6) M) enhanced the relaxations due to adenosine and ATP while theophylline (10(-6) M) inhibited the relaxations due to adenosine and ATP. The results suggest the presence of P1-type purinoceptors in the bronchial artery of cattle.
Alexander
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Eyre
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D000241:Adenosine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001981:Bronchial Arteries / Q000187:drug effects* / Q000502:physiology; D002417:Cattle; D004176:Dipyridamole / Q000494:pharmacology; D066298:In Vitro Techniques; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D011983:Receptors, Purinergic; D014664:Vasodilation
D017981:Receptors, Neurotransmitter; D011983:Receptors, Purinergic; D004176:Dipyridamole; D000255:Adenosine Triphosphate; D000241:Adenosine