HLA-B18 is associated with decreased levels of isoproterenol-stimulated cAMP in lymphocytes.
One hundred fifty-nine individuals were typed for HLA-A and B antigens and levels of isoproterenol-stimulated, lymphocyte cAMP. No significant age, sex, or caffeine effects on the natural log of the lymphocyte cAMP variable (ln cAMP) were found. A comparison of mean ln cAMP levels between individuals who carried a particular antigen (homozygous or heterozygous) and individuals who did not carry the antigen identified a highly significant decrease in ln cAMP levels associated with the HLA-B18 antigen. We estimated that 18.9% of the variability in ln cAMP was attributable to the HLA-B18 antigen. In addition, 38% of the variability in ln cAMP was attributable to factors that aggregate in families that were independent of the HLA-B18 effect. A weaker association of A10 with lymphocyte cAMP might be due to linkage disequilibrium between A10 and B18.
Erickson
R P
RP
Pairitz
G L
GL
Karolyi
J M
JM
Kapur
J J
JJ
Odenheimer
D J
DJ
Schultz
J S
JS
Sing
C F
CF
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002972:Cleft Palate / Q000097:blood / Q000235:genetics; D000242:Cyclic AMP / Q000235:genetics* / Q000378:metabolism; D003550:Cystic Fibrosis / Q000097:blood / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059911:HLA-B18 Antigen; D006801:Humans; D007223:Infant; D007545:Isoproterenol / Q000494:pharmacology*; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D005819:Genetic Markers; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059911:HLA-B18 Antigen; D000242:Cyclic AMP; D007545:Isoproterenol