Subcellular localization of the product of the long open reading frame of human T-cell leukemia virus type I.
Human T-cell leukemia virus type I (HTLV-I) is a retrovirus associated with adult T-cell leukemia and lymphoma. In addition to containing the gag, pol, and env genes of the chronic leukemia viruses, the genome of HTLV-I contains a long open reading frame (LOR) located between the 3' end of the envelope gene and the 3' long terminal repeat sequence (LTR). It has been suggested that a protein of 42 kilodaltons that is encoded by the LOR region may participate in both trans-acting transcriptional regulation of the viral LTR as well as in the transforming properties of HTLV-I. It is reported here that a significant fraction of the 42-kilodalton HTLV LOR product is located in the nucleus of HTLV-I-infected transformed lymphocytes, a finding that is consistent with its proposed functions.
Goh
W C
WC
Sodroski
J
J
Rosen
C
C
Essex
M
M
Haseltine
W A
WA
D002458:Cell Fractionation; D002467:Cell Nucleus / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D017977:Deltaretrovirus / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D009363:Neoplasm Proteins / Q000235:genetics / Q000302:isolation & purification*; D009857:Oncogenes; D013347:Subcellular Fractions / Q000378:metabolism
D009363:Neoplasm Proteins