Continuous subcutaneous lisuride infusions in Parkinson's disease.
Thirteen patients with idiopathic Parkinson's disease and "on-off" fluctuations on oral levodopa plus dopa decarboxylase inhibitor (DDI) were treated with continuous (24 hour) subcutaneous lisuride infusions together with a reduced dose of levodopa (plus DDI). An improvement in motor performance was seen in 10 patients, with a mean increase in percentage of waking time spent "on" of 32 per cent (range 13-59 percent). However, adverse effects were common, especially psychiatric effects, leading to treatment withdrawal in 11 of 13 subjects after a mean of 40 days' treatment. Continuous lisuride infusion together with a small dose of levodopa (plus DDI) are effective treatment for "on-off" fluctuations in Parkinson's disease, but the frequency of adverse effects limits the number of patients who can be treated successfully with this technique.
Critchley
P H
PH
University Department of Neurology, Institute of Psychiatry, London, U.K.
Grandas Perez
F
F
Quinn
N P
NP
Parkes
J D
JD
Marsden
C D
CD
D000328:Adult; D000368:Aged; D003875:Drug Eruptions; D004409:Dyskinesia, Drug-Induced; D004873:Ergolines / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007260:Infusion Pumps; D008090:Lisuride / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced; D008875:Middle Aged; D009068:Movement / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology
D004873:Ergolines; D008090:Lisuride