Vasorelaxant effects of atrial peptide II on isolated human pulmonary muscle preparations.
Isolated human pulmonary arterial preparations were approximately 10-fold more sensitive to atrial peptide II than venous preparations (pD2 values: 7.11 +/- 0.14 and 6.17 +/- 0.14, respectively). Atrial peptide II did not relax isolated human bronchial muscle preparations (pD2 value: greater than 5.5). These data demonstrate that atrial peptide II is a selective relaxant agent in isolated human pulmonary vascular muscle preparations with no effect on isolated human airway muscle preparations.
Labat
C
C
INSERM U200 32, Clamart, France.
Norel
X
X
Benveniste
J
J
Brink
C
C
D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009842:Oligopeptides / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000187:drug effects; D011667:Pulmonary Veins / Q000187:drug effects; D012132:Respiratory Muscles / Q000187:drug effects*
D009842:Oligopeptides; C029579:antiarrhythmic peptide; D009320:Atrial Natriuretic Factor