Effects of intravenous ethanol on hepatic and pancreatic blood flow in dogs.
Changes in hepatic and pancreatic blood flow in response to ethanol infusion were determined simultaneously and continuously in anesthetized dogs, using a transit-time ultrasonic flowmeter and a laser-Doppler flowmeter. In addition, the effect of intravenous ethanol on exocrine pancreatic secretion was investigated. With a background infusion of secretin, ethanol (1.3 g/kg body wt) was infused intravenously over a 40-min period. Ethanol infusion significantly increased blood flow in the common hepatic artery (by 49%, at the time of the cessation of ethanol infusion), and this increased flow was maintained for 60 min after the cessation of ethanol infusion. In contrast, blood flow in the portal vein was not altered significantly by ethanol. Pancreatic blood flow and secretion showed no significant difference from those seen in the controls. Our data suggest that intravenous ethanol induces a redistribution of the splanchnic blood flow. The increased hepatic arterial flow seen in response to ethanol may play an important role in preventing ethanol-induced hypoxic liver damage.
Kogire
M
M
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Inoue
K
K
Doi
R
R
Sumi
S
S
Takaori
K
K
Yun
M
M
Suzuki
T
T
Tobe
T
T
D000818:Animals; D004285:Dogs; D000431:Ethanol / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008102:Liver Circulation / Q000187:drug effects*; D010179:Pancreas / Q000098:blood supply*; D012039:Regional Blood Flow / Q000187:drug effects; D012212:Rheology; D013152:Splanchnic Circulation / Q000187:drug effects*; D013268:Stimulation, Chemical; D013997:Time Factors
D000431:Ethanol