title: Effects of acute behavioral stress on plasma and cerebrospinal fluid ACTH and beta-endorphin in rhesus monkeys.
abstract: To elucidate the effect of acute behavioral stress on plasma and cerebrospinal fluid (CSF) concentrations of adrenocorticotropic hormone (ACTH) and beta-endorphin, rhesus monkeys were subjected to 30 min of confinement stress. Simultaneous plasma and CSF samples revealed no significant change in CSF ACTH or beta-endorphin up to 120 min after the onset of the stress despite significant elevations in plasma cortisol, ACTH, and beta-endorphin. It is suggested that acute behavioral stress does not alter CSF ACTH or beta-endorphin, and that this information may be clinically useful for future human studies of CSF ACTH and beta-endorphin in neuropsychiatric illnesses.
authors.forename: N H
authors.initials: NH
authors.lastname: Kalin
authors.forename: M
authors.initials: M
authors.lastname: Carnes
authors.forename: C M
authors.initials: CM
authors.lastname: Barksdale
authors.forename: S E
authors.initials: SE
authors.lastname: Shelton
authors.forename: R D
authors.initials: RD
authors.lastname: Stewart
authors.forename: S C
authors.initials: SC
authors.lastname: Risch
mesh_terms: D000208:Acute Disease; D000324:Adrenocorticotropic Hormone / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D000818:Animals; D004723:Endorphins / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D013315:Stress, Psychological / Q000378:metabolism*; D001615:beta-Endorphin
chemical_list: D004723:Endorphins; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone