title: Ketanserin does not prevent ACTH-induced hypertension in sheep.
abstract: The role of serotonin (5HT) in the pathogenesis of ACTH-induced hypertension in sheep has been examined. The pressor responses to injections of 5HT (0.1-30 micrograms/kg) were similar in normotensive and hypertensive sheep. Prior treatment with the 5HT2 receptor antagonist ketanserin had no effect on the development of hypertension produced by ACTH administration.
authors.forename: M A
authors.initials: MA
authors.lastname: Nelson
authors.forename: J P
authors.initials: JP
authors.lastname: Coghlan
authors.forename: D A
authors.initials: DA
authors.lastname: Denton
authors.forename: J A
authors.initials: JA
authors.lastname: Whitworth
authors.forename: B A
authors.initials: BA
authors.lastname: Scoggins
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000037:antagonists & inhibitors*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006973:Hypertension / Q000503:physiopathology* / Q000517:prevention & control; D007650:Ketanserin; D010880:Piperidines / Q000494:pharmacology*; D012701:Serotonin / Q000502:physiology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D012756:Sheep
chemical_list: D010880:Piperidines; D012702:Serotonin Antagonists; D012701:Serotonin; D000324:Adrenocorticotropic Hormone; D007650:Ketanserin