Prevention of ischemic and postischemic brain edema by a novel calcium antagonist (PN200-110).
The effect of PN200-110, a novel calcium antagonist, on the formation of brain edema was examined with rats using a middle cerebral artery (MCA) occlusion model. PN200-110 was effective in preventing the formation of brain edema in 6-h ischemia and in 3-h reperfusion following 3-h ischemia, which were cases in which great accumulations of calcium were autoradiographically observed. Furthermore, PN200-110 diminished the excessive accumulation of calcium in the MCA area involved. These results indicate that an inhibition of the massive influx of calcium into brain cells by PN200-110 may partially ameliorate cell damage, resulting in prevention of brain edema.
Abe
K
K
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Kogure
K
K
Watanabe
T
T
D000818:Animals; D001345:Autoradiography; D001929:Brain Edema / Q000517:prevention & control*; D002545:Brain Ischemia / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D017275:Isradipine; D010069:Oxadiazoles / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D010069:Oxadiazoles; D002118:Calcium; D017275:Isradipine