title: Involvement of spot 35 protein, a cerebellar protein, in modulation of Purkinje cell activity of the rat cerebellum.
abstract: Spot 35 protein, applied iontophoretically, produced inhibition of spontaneous Purkinje cell activity in most cells and augmented the NE- or 5-HT-induced inhibition of spontaneous discharges whereas it hardly affected the inhibitory response of Purkinje cells to GABA, taurine, and beta-alanine, and the excitatory response to glutamate. It is suggested that spot 35 protein may be involved in normal physiological operation of the cerebellum through modulation of the NE or 5-HT system.
authors.forename: S
authors.initials: S
authors.lastname: Maruyama
authors.forename: G
authors.initials: G
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Tamura
authors.forename: T
authors.initials: T
authors.lastname: Yamakuni
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D064092:Calbindin 1; D064026:Calbindins; D002135:Calcium-Binding Proteins; D002531:Cerebellum; D000242:Cyclic AMP / Q000494:pharmacology; D006152:Cyclic GMP / Q000494:pharmacology; D004347:Drug Interactions; D007478:Iontophoresis; D008297:Male; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D011689:Purkinje Cells / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D064030:S100 Calcium Binding Protein G; D012701:Serotonin / Q000494:pharmacology
chemical_list: C576500:Calb1 protein, rat; D064092:Calbindin 1; D064026:Calbindins; D002135:Calcium-Binding Proteins; D009419:Nerve Tissue Proteins; D064030:S100 Calcium Binding Protein G; D012701:Serotonin; D000242:Cyclic AMP; D006152:Cyclic GMP; D009638:Norepinephrine