[Transmembrane potential and electrogenicity of thrombocyte Na, K-ATPase in different forms of hypertension in rats].
The fluorescent dye 3,3'-dipropylthiadicarbocyanine iodide, dis-C3-(5), was used to study the membrane potential of platelets in rats with renal, DOCA-induced and spontaneous hypertension. The magnitude of the transmembrane potential in platelets combines the activity of electrogenic Na, K-ATPase and the rate of ion diffusion across the plasma membrane. The basal potential is 12 = 14 mB as lowered only in spontaneously hypertensive rats. The decrease of the basal potential is made for electrogenicity of platelet Na, K-ATPase in spontaneously hypertensive rats.
Kravtsov
G M
GM
Postnova
N A
NA
Postnov
Iu V
IuV
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D003900:Desoxycorticosterone / Q000633:toxicity; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D006977:Hypertension, Renal / Q000503:physiopathology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D010042:Ouabain / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology*; D013050:Spectrometry, Fluorescence / Q000379:methods
D003900:Desoxycorticosterone; D010042:Ouabain; D011189:Potassium Chloride; D000254:Sodium-Potassium-Exchanging ATPase
Transmembrannyĭ potentsial i élektrogennost' Na, K-ATFazy trombotsitov pri razlichnykh formakh gipertenzii u krys.