Synthesis of transcobalamin II by cultured human hepatocytes.
Cultured HepG2 cells, derived from a human hepatoma synthesized and released unsaturated, immunoreactive transcobalamin II. Synthesis was confirmed by the blocking with inhibitors of protein synthesis and by incorporation of tritiated leucine into transcobalamin II.
Hall
C A
CA
Green-Colligan
P D
PD
Begley
J A
JA
D001059:Apoproteins / Q000096:biosynthesis; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D002460:Cell Line; D003513:Cycloheximide / Q000494:pharmacology; D006801:Humans; D007158:Immunologic Techniques; D007930:Leucine / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism*; D014155:Transcobalamins / Q000096:biosynthesis*
D001059:Apoproteins; D014155:Transcobalamins; D003513:Cycloheximide; D007930:Leucine