[Effect of different fractions obtained by gel filtration of a chalone-containing preparation from Ehrlich ascites tumor on mitotic activity and DNA synthesis in this tumor].
The effect of various fractions of chalone-containing preparation from ascite Ehrlich's tumour obtained by gel filtration on ultragel Ac-A-44 on mitotic activity and DNA synthesis in the tumour has been studied. The chalone-containing preparation (alcohol precipitate) was shown to suppress entering of tumour cells into M- and S-phase and DNA synthesis. After gel filtration, the partial division of active chalone component which inhibits entering of cells into M- and S-phase took place. The component inhibiting DNA synthesis eluted with G1-chalone.
Matsak
N Ia
NIa
Antokhin
A I
AI
Romanov
Iu A
IuA
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism / Q000473:pathology*; D002850:Chromatography, Gel; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects*; D003864:Depression, Chemical; D006131:Growth Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D007399:Interphase / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects*
D004273:DNA, Neoplasm; D006131:Growth Inhibitors
Vliianie razlichnykh fraktsiĭ, poluchennykh pri gel'-fil'tratsii keĭlonsoderzhashchego preparata iz astsitnoĭ opukholi Erlikha, na mitoticheskuiu aktivnost' i sintez DNK v étoĭ opukholi.