title: Infection of the basal ganglia by a murine coronavirus.
abstract: The coronavirus, mouse hepatitis virus strain A59 (MHV-A59), causes mild encephalitis and chronic demyelination. Immunohistochemical techniques showed that MHV-A59-infected C57BL/6 mice contained dense deposits of viral antigen in the subthalamic nucleus and substantia nigra, with fewer signs of infection in other regions of the brain. The animals showed extra- and intracellular vacuolation, neuronal loss, and gliosis in the subthalamic-nigral region. Such localization is unprecedented among known viral encephalitides of humans and other species. This infection by a member of a viral class capable of causing both encephalitis and persistent infection in several species may be related to postencephalitic parkinsonism.
authors.forename: P S
authors.initials: PS
authors.lastname: Fishman
authors.forename: J S
authors.initials: JS
authors.lastname: Gass
authors.forename: P T
authors.initials: PT
authors.lastname: Swoveland
authors.forename: E
authors.initials: E
authors.lastname: Lavi
authors.forename: M K
authors.initials: MK
authors.lastname: Highkin
authors.forename: S R
authors.initials: SR
authors.lastname: Weiss
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001479:Basal Ganglia / Q000382:microbiology*; D001921:Brain / Q000382:microbiology / Q000473:pathology; D003333:Coronaviridae Infections / Q000382:microbiology*; D003711:Demyelinating Diseases / Q000382:microbiology; D004027:Diencephalon / Q000382:microbiology*; D004660:Encephalitis / Q000382:microbiology*; D004721:Endoplasmic Reticulum / Q000382:microbiology; D005911:Gliosis / Q000382:microbiology; D006056:Golgi Apparatus / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D006517:Murine hepatitis virus / Q000276:immunology; D009474:Neurons / Q000382:microbiology / Q000648:ultrastructure; D013378:Substantia Nigra / Q000382:microbiology*; D014617:Vacuoles / Q000648:ultrastructure
chemical_list: D000956:Antigens, Viral