title: Peripheral neuropathy during longterm high-dose amiodarone therapy.
abstract: Three patients developed peripheral neuropathy after taking amiodarone for more than 18 months. All had high serum concentrations of amiodarone and its desethyl metabolite; in one patient concentrations in a sural nerve biopsy were 80 times higher than in serum. Peripheral neuropathy is a complication of large doses of amiodarone taken over long periods.
authors.forename: A G
authors.initials: AG
authors.lastname: Fraser
authors.forename: I N
authors.initials: IN
authors.lastname: McQueen
authors.forename: A H
authors.initials: AH
authors.lastname: Watt
authors.forename: M R
authors.initials: MR
authors.lastname: Stephens
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000097:blood; D001572:Benzofurans / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*
chemical_list: D001572:Benzofurans; C036116:desethylamiodarone; D000638:Amiodarone