Neutralising antibody against type 1 and type 2 herpes simplex virus in cervical mucus of women with cervical intra-epithelial neoplasia.
Patients with cervical intra-epithelial neoplasia had significantly increased neutralising antibody activity to type 2 herpes simplex virus in the cervical mucus. While patients differed from control subjects with respect to their number of sexual partners and socio-economic class, there were significant differences in neutralising antibody activity for case control comparisons within the same number of sexual partners or socio-economic groupings. The results lend support to the putative association between type 2 herpes simplex virus infection and pre-invasive and invasive carcinoma of the uterine cervix.
Murphy
J F
JF
Murphy
D F
DF
Barker
S
S
Mylotte
M L
ML
Coughlan
B M
BM
Skinner
G R
GR
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D002582:Cervix Mucus / Q000276:immunology*; D005260:Female; D006801:Humans; D008597:Menstrual Cycle; D008875:Middle Aged; D009500:Neutralization Tests; D012725:Sexual Behavior; D018139:Simplexvirus / Q000276:immunology*; D012959:Socioeconomic Factors; D002583:Uterine Cervical Neoplasms / Q000276:immunology*
D000914:Antibodies, Viral