The chemical synthesis and antiviral properties of an acyclovir-phospholipid conjugate.
The synthesis of acyclovir-phospholipid conjugate (2) is reported through an unambiguous one-step preparation of L-alpha-dimyristoyl phosphatidic acid triethylammonium salt (5). The biological activity of 2 as an antiviral drug has also been investigated.
Welch
C J
CJ
Larsson
A
A
Ericson
A C
AC
Oberg
B
B
Datema
R
R
Chattopadhyaya
J
J
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D005347:Fibroblasts / Q000187:drug effects; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000188:drug therapy; D006801:Humans; D051379:Mice; D010743:Phospholipids / Q000138:chemical synthesis / Q000627:therapeutic use; D018139:Simplexvirus / Q000187:drug effects; D012874:Skin Diseases, Infectious / Q000188:drug therapy; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D010743:Phospholipids; D000212:Acyclovir