Converting enzyme inhibition and the common carotid circulation in older patients with sustained essential hypertension.
Arterial diameter, blood flow and vascular resistance of the common carotid artery were studied using a pulsed Doppler system in patients with uncomplicated sustained essential hypertension and compared with age-matched normal subjects. In hypertensive patients below the age of 45 years, arterial diameter and blood flow remained within the normal range, while vascular resistance was increased. In hypertensive patients over 45 years of age, arterial diameter was also normal, but blood flow was reduced and vascular resistance markedly increased. Thus, both small and large arteries were altered in the common carotid circulation of patients with sustained essential hypertension. Acute oral administration of converting enzyme inhibitor produced dilatation of both small (vascular resistance) and large (arterial diameter) arteries in the carotid circulation. In addition, in older patients, blood flow significantly increased and vascular resistance markedly decreased both in acute and long-term situations. Thus converting enzyme inhibition was able to reverse the abnormalities of the common carotid circulation of older subjects with sustained essential hypertension.
Safar
M
M
Diagnosis Centre, Hopital Broussais, Paris, France.
Asmar
R
R
Bouthier
J
J
Lacolley
P
P
Laurent
S
S
D000328:Adult; D000367:Age Factors; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002339:Carotid Arteries / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects; D012212:Rheology; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use
D000806:Angiotensin-Converting Enzyme Inhibitors; D014665:Vasodilator Agents