Interferons inhibit syncytia-forming ability and in vitro transmission of human T-cell leukemia virus.
Interferon(IFN)-alpha and -beta strongly inhibited syncytia formation of human T-cell leukemia virus (HTLV). They also inhibited transmission of HTLV to normal human fibroblasts. These phenomena suggest a physiological role of IFNs in defense against HTLV infection.
Nishida
J
J
Yoshikura
H
H
Okabe
T
T
Urabe
A
A
Takaku
F
F
D000818:Animals; D002415:Cats; D017977:Deltaretrovirus / Q000187:drug effects* / Q000378:metabolism; D005347:Fibroblasts / Q000382:microbiology; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007938:Leukemia / Q000635:transmission*; D008715:Methionine / Q000378:metabolism; D014412:Tumor Virus Infections / Q000635:transmission*; D014764:Viral Proteins / Q000096:biosynthesis
D007370:Interferon Type I; D014764:Viral Proteins; D008715:Methionine