Effect of four non-ionic contrast media on red blood cells in vitro. III. Deformability.
The influence of four non-ionic contrast media and one ionic contrast medium was analyzed on red blood cell deformability in vitro. The newly synthesized non-ionic monomeric iopentol and dimeric iodixanol were compared with the currently used non-ionic monomers iopamidol and iohexol and the ionic monomeric diatrizoate at a constant hematocrit of 8%. The effect on red blood cell deformability was analyzed in 50% volume ratio solutions of both original hypertonic and isotonic contrast media solutions. The samples were studied in a red blood cell filtrometer through new Mynipore microsieves using an improved procedure of data processing. Diatrizoate induced significantly more red blood cell rigidification compared with all non-ionic contrast media solutions and normal blood. There was no difference between the investigated non-ionic contrast media, nor between the non-ionic contrast media and normal blood without additive.
Aspelin
P
P
Department of Diagnostic Radiololgy, Malmö Allmänna Sjukhus, Sweden.
Nilsson
P E
PE
Schmid-Schönbein
H
H
Schröder
S
S
Simon
R
R
D003287:Contrast Media / Q000494:pharmacology*; D004907:Erythrocyte Deformability / Q000187:drug effects*; D006801:Humans; D007472:Iohexol / Q000494:pharmacology; D007479:Iopamidol / Q000494:pharmacology; D014283:Triiodobenzoic Acids / Q000494:pharmacology
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C053571:iopentol; C044834:iodixanol; D007479:Iopamidol