Cross-tolerance to the hypothermic effect of delta 8-tetrahydrocannabinol 11-hydroxy-delta 8-tetrahydrocannabinol and chlorpromazine in the mouse.
When a 5 mg/kg i.v. dose of delta 8-tetrahydrocannabinol (delta 8-THC) and 11-hydroxy-delta 8-tetrahydrocannabinol (11-OH-delta 8-THC) was administered daily to mice, tolerance to their hypothermic effects developed quickly. Cross-tolerance to the hypothermic effect also developed between delta 8-THC and 11-OH-delta 8-THC. Tolerance development was dose-dependent and dose-effect experiments indicated that the magnitude of the tolerance developed to 11-OH-delta 8-THC was greater than that to delta 8-THC. Both cannabinoids were cross-tolerant to chlorpromazine in the hypothermic effect, but not to morphine, pentobarbital and reserpine under the conditions used. The present results suggest that 11-OH-delta 8-THC has some role in the development of tolerance to the hypothermic effect of delta 8-THC in mice.
Yamamoto
I
I
Watanabe
K
K
Narimatsu
S
S
Hamajima
K
K
Yoshimura
H
H
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004361:Drug Tolerance; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology
C020367:11-hydroxy-delta(8)-tetrahydrocannabinol; C035731:delta-8-tetrahydrocannabinol; D009020:Morphine; D013759:Dronabinol; D012110:Reserpine; D010424:Pentobarbital; D002746:Chlorpromazine