Persistent Epstein-Barr virus infection and a histiocytic sarcoma in a renal transplant recipient.
Lymphomas occurring in renal transplant recipients are mostly large cell non-Hodgkin's lymphomas (B-cell-derived). A sarcoma with all morphologic, immunohistochemical, and ultrastructural characteristics of a tumor of the mononuclear phagocytic system (MPS) developed in a 23-year-old woman 1 year after renal transplantation. Anti-Epstein-Barr-virus antibody titers proved to be exceptionally high, even in pretransplant sera. Tumor-derived cells proved to be positive for Epstein-Barr nuclear antigen (EBNA), and hybridization showed multiple copies of Epstein-Barr virus (EBV)-DNA, suggesting a relationship between this tumor and EBV. More widespread use of immunochemical and histochemical diagnostic techniques might detect more cases, which, until now, have probably been diagnosed as B-cell-derived immunoblastic lymphomas.
Kramer
P
P
Prins
M E
ME
Kapsenberg
J G
JG
Bornkamm
G W
GW
Bijnen
A B
AB
Rohol
P J
PJ
van der Heul
R O
RO
Jeekel
J
J
Weimar
W
W
D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000032:analysis; D001932:Brain Neoplasms / Q000556:secondary; D002213:Capsid / Q000276:immunology; D004279:DNA, Viral / Q000032:analysis; D019309:Epstein-Barr Virus Nuclear Antigens; D005260:Female; D006566:Herpesviridae Infections / Q000209:etiology* / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D007680:Kidney Neoplasms / Q000209:etiology* / Q000276:immunology; D016030:Kidney Transplantation; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology* / Q000276:immunology / Q000556:secondary; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000556:secondary / Q000648:ultrastructure
D000914:Antibodies, Viral; D000956:Antigens, Viral; D004279:DNA, Viral; D019309:Epstein-Barr Virus Nuclear Antigens