The effect of nicotine on the delay of gastric emptying.
The effect of cigarette smoking and its active component, nicotine, on the gastric emptying of solid food was assessed in a randomized double-blind crossover design. Ten regular smokers were studied after a 6 h fast and least 18 h after their last cigarette. Subjects smoked a total of three high (1.91 mg) or low (0.17 mg) nicotine cigarettes, before and after a technetium-labelled solid meal and were scanned by gamma camera periodically over a 2-h period. All calculations of gastric emptying revealed a significant delay after smoking high versus low nicotine cigarettes in: mean per cent isotope remaining in the stomach at each measurement point from 90-120 min; amount of meal remaining in the stomach at 2 h; and mean time at which 50% of the meal had emptied (T1/2). Delay in gastric emptying was significantly correlated with increase in serum nicotine concentration on the high nicotine day.
Gritz
E R
ER
Division of Cancer Control, Jonsson Comprehensive Cancer Center, University of California, Los Angeles 90024.
Ippoliti
A
A
Jarvik
M E
ME
Rose
J E
JE
Shiffman
S
S
Harrison
A
A
Van Vunakis
H
H
D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005502:Food; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000494:pharmacology*; D012907:Smoking / Q000503:physiopathology*
D009538:Nicotine