[Immunocytologic study of light cell lines established in vitro from Ewing's sarcoma. Identification of neural markers].
Using immunocytological techniques, neuroectodermal markers were identified on Ewing's sarcoma cell lines established in vitro and carrying the chromosomal translocation t(11;22). Eight cell lines were tested using a panel of monoclonal antibodies. The presence of cell surface antigens recognized by HNK-1 antibody was confirmed. The cells showed also positive reactions using antibodies directed against Neuron-Specific-Enolase and neurofilament proteins. The presence of these neural markers in the Ewing's sarcoma cells tested is an additional argument substantiating the putative neural origin of this tumor.
Lizard-Nacol
S
S
Justrabo
E
E
Mugneret
F
F
Volk
C
C
Turc-Carel
C
C
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D002460:Cell Line; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000032:analysis; D016900:Neurofilament Proteins; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D012512:Sarcoma, Ewing / Q000032:analysis / Q000473:pathology*
D014408:Biomarkers, Tumor; D007381:Intermediate Filament Proteins; D016900:Neurofilament Proteins; D010751:Phosphopyruvate Hydratase
Etude immunocytologique de huit lignées cellulaires établies in vitro de "sarcome d'Ewing". Identification de marqueurs neuraux.