Changes induced in rabbit plasma and aqueous humour by ACTH4-10 and ACTH1-24.
In the rabbit the effect of a single i.m. dose of ACTH4-10 (130 micrograms kg-1) was compared with that of ACTH1-24 (20 micrograms kg-1). In contrast to ACTH1-24 the heptapeptide ACTH4-10 did not stimulate the adrenal secretion of corticosterone. Both ACTH fragments induced a slight hyperglycemia and in the aqueous humour they increased the concentration of proteins.
Stárka
L
L
Hampl
R
R
Simecková
A
A
Obenberger
J
J
Drouhault
R
R
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001082:Aqueous Humor / Q000032:analysis; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D002118:Calcium / Q000097:blood; D003345:Corticosterone / Q000097:blood; D003366:Cosyntropin / Q000494:pharmacology*; D005260:Female; D007328:Insulin / Q000097:blood; D010446:Peptide Fragments / Q000494:pharmacology*; D010758:Phosphorus / Q000097:blood; D011817:Rabbits
D001786:Blood Glucose; D001798:Blood Proteins; D007328:Insulin; D010446:Peptide Fragments; D003366:Cosyntropin; D010758:Phosphorus; D000324:Adrenocorticotropic Hormone; D000469:Alkaline Phosphatase; C011394:ACTH (4-10); D002118:Calcium; D003345:Corticosterone