Monoclonal antibodies specific for p24, the major core protein of human T-cell leukemia virus type III.
Four mouse hybridomas secreting monoclonal antibodies specific for p24, the major core antigen of the human T-cell leukemia virus type III (HTLV-III), have been developed, and their specificities have been partially characterized. These antibodies specifically recognized p24 of HTLV-III in extracts of HTLV-III and in HTLV-III-producing cells. No epitopes cross-reactive with HTLV-I and -II were detected with these antibodies. These hybridomas will be extremely valuable reagents in identifying expression of HTLV-III in infected cultures and in cells or tissues from patients with suspected immunodeficiency syndrome.
di Marzo Veronese
F
F
Sarngadharan
M G
MG
Rahman
R
R
Markham
P D
PD
Popovic
M
M
Bodner
A J
AJ
Gallo
R C
RC
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D000918:Antibody Specificity; D017977:Deltaretrovirus / Q000276:immunology*; D006801:Humans; D008970:Molecular Weight; D014758:Viral Core Proteins; D014764:Viral Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D014758:Viral Core Proteins; D014764:Viral Proteins