title: Prediction of survival in glioma patients by means of positron emission tomography.
abstract: The aim of this study was to determine whether positron emission tomography (PET) with fluorine-18 (18F)-2-deoxyglucose (FDG) can be used as a prognostic test in patients with high-grade cerebral gliomas, regardless of the treatment given. Forty-five patients with astrocytoma Grade III or IV were included in this analysis. The mean survival time of patients with tumors exhibiting high glucose utilization as determined by PET-FDG was 5 months, whereas patients with gliomas showing lower glucose utilization had a mean survival period of 19 months. It is postulated that PET-FDG scans reflect the biological behavior of high-grade astrocytomas and may be used to predict the survival time of patients harboring such neoplasms.
authors.forename: N J
authors.initials: NJ
authors.lastname: Patronas
authors.forename: G
authors.initials: G
authors.lastname: Di Chiro
authors.forename: C
authors.initials: C
authors.lastname: Kufta
authors.forename: D
authors.initials: D
authors.lastname: Bairamian
authors.forename: P L
authors.initials: PL
authors.lastname: Kornblith
authors.forename: R
authors.initials: R
authors.lastname: Simon
authors.forename: S M
authors.initials: SM
authors.lastname: Larson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005260:Female; D005461:Fluorine; D019788:Fluorodeoxyglucose F18; D005909:Glioblastoma / Q000000981:diagnostic imaging* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D011868:Radioisotopes; D014055:Tomography, Emission-Computed
chemical_list: D011868:Radioisotopes; D019788:Fluorodeoxyglucose F18; D005461:Fluorine; D003847:Deoxyglucose