Bullous pemphigoid mimicking bullous erythema multiforme: an untoward side effect of penicillins.
Three young and middle-aged patients developed severe bullous eruption after receiving various penicillins. The clinical findings included high fever, prostration, widespread bullous eruption mainly on the head, face, and extremities, targetlike lesions on the palms and soles, and severe erosions in almost all the mucous membranes. Direct and indirect immunofluorescence studies were those of bullous pemphigoid. Complete clearing of the eruption occurred with prednisone therapy. We conclude that drug-induced bullous pemphigoid is a different entity from the classic bullous pemphigoid.
Alcalay
J
J
Department of Dermatology, Beilinson Medical Center, Petah Tiqva, Israel.
David
M
M
Ingber
A
A
Hazaz
B
B
Sandbank
M
M
D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000009:adverse effects*; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis*; D004892:Erythema Multiforme / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010391:Pemphigoid, Bullous / Q000139:chemically induced* / Q000175:diagnosis; D010400:Penicillin G / Q000009:adverse effects*; D010402:Penicillin G Procaine / Q000009:adverse effects*; D010404:Penicillin V / Q000009:adverse effects*; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*
D010402:Penicillin G Procaine; D000658:Amoxicillin; D010400:Penicillin G; D010404:Penicillin V