title: Changes in lipid peroxide concentrations in plasma and tissues by repeated administration of clioquinol to neonatal rats.
abstract: The changes in lipid peroxide concentrations in plasma and tissues after subcutaneous administration of clioquinol to clioquinol-sensitive (S-rats) and -resistant neonatal rats (R-rats) were investigated. When a fixed dose of 150 mg/kg/d of clioquinol was given to R-rats for 14 d after birth, no significant difference in lipid peroxide concentrations in plasma, liver, kidney, brain and spinal cord at 5, 10 and 15 d was observed between clioquinol-treated and untreated rats. However, with increasing doses of clioquinol to R-rats every 5 d (150----300----600 mg/kg/d), the lipid peroxide concentrations at 15 d were higher in plasma, brain and spinal cord of clioquinol-treated rats than in those of untreated rats. These results suggested that repeated administrations of large doses of clioquinol to rats increased the lipid peroxides in nerve tissues. With S-rats at 5 d after birth, the lipid peroxide concentrations in liver were approximately twice those in R-rats regardless of the clioquinol administration.
authors.affiliation: Hospital Pharmacy, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ohshima
authors.forename: H
authors.initials: H
authors.lastname: Kotaki
authors.forename: S
authors.initials: S
authors.lastname: Hori
authors.forename: Y
authors.initials: Y
authors.lastname: Saitoh
authors.forename: F
authors.initials: F
authors.lastname: Nakagawa
authors.forename: Z
authors.initials: Z
authors.lastname: Tamura
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000097:blood / Q000378:metabolism*; D001259:Ataxia / Q000139:chemically induced; D001835:Body Weight / Q000187:drug effects; D002490:Central Nervous System / Q000378:metabolism; D007464:Clioquinol / Q000008:administration & dosage / Q000494:pharmacology*; D004351:Drug Resistance; D005260:Female; D006912:Hydroxyquinolines / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006912:Hydroxyquinolines; D008054:Lipid Peroxides; D007464:Clioquinol