title: Human T-cell leukemia virus x gene.
abstract: The human T-cell leukemia virus (HTLV) types I and II are associated with specific hematological cancers. These viruses rapidly transform normal T-lymphocytes in vitro. The mechanism of HTLV-induced leukemogenesis is unknown. Structural analysis of HTLV-I and HTLV-II has revealed sequences of unknown function, termed X, at the 3' end of the proviral genome. The distal two-thirds of the X sequences are highly conserved between HTLV-I and HTLV-II. We have shown that these conserved X sequences contain a gene, termed x, that is expressed in both HTLV-I and HTLV-II by identifying a subgenomic X RNA as well as the proteins encoded by these messages. The function of this unique x gene is unknown; however, its conservation and expression suggest that it may play a role in HTLV replication and in HTLV-induced leukemogenesis.
authors.forename: W
authors.initials: W
authors.lastname: Wachsman
authors.forename: D
authors.initials: D
authors.lastname: Slamon
authors.forename: K
authors.initials: K
authors.lastname: Shimotohno
authors.forename: D W
authors.initials: DW
authors.lastname: Golde
authors.forename: I S
authors.initials: IS
authors.lastname: Chen
mesh_terms: D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D003062:Codon; D017977:Deltaretrovirus / Q000235:genetics* / Q000502:physiology; D005786:Gene Expression Regulation; D005796:Genes; D005814:Genes, Viral; D006801:Humans; D009842:Oligopeptides / Q000096:biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D013601:T-Lymphocytes / Q000382:microbiology; D014158:Transcription, Genetic; D014764:Viral Proteins / Q000096:biosynthesis / Q000235:genetics; D014779:Virus Replication
chemical_list: D003062:Codon; D009842:Oligopeptides; D012333:RNA, Messenger; D012367:RNA, Viral; D014764:Viral Proteins