[Immunologically mediated induction of hyperlipoproteinemia].
The relationship of immune and metabolic processes, particularly, those of lipid metabolism, was studied in mice with diet induced hyperlipoproteinemia, leukemia-related immune deficiency and in situ formation of antigen-antibody complexes after immunostimulation. A marked immunosuppression was observed in mice on a high-cholesterol diet, but when immune complex formation was induced after antigen injection, a high level of nonesterified cholesterol and low density lipoproteins was obtained, whereas an increase in high density lipoproteins in leukemic mice was observed. It is concluded that there exists a certain mechanism of immunologically mediated induction of hyperlipoproteinemia, which leads to the inhibition of immune response by immunoregulatory lipoproteins under conditions of antigen stimulation.
Osipov
S G
SG
Titov
V N
VN
Rumiantsev
A G
AG
D000818:Animals; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D006949:Hyperlipidemias / Q000097:blood / Q000209:etiology / Q000276:immunology; D006951:Hyperlipoproteinemias / Q000097:blood / Q000209:etiology* / Q000276:immunology; D007105:Immune Complex Diseases / Q000097:blood / Q000276:immunology; D007121:Immunocompetence; D007153:Immunologic Deficiency Syndromes / Q000097:blood / Q000276:immunology; D007942:Leukemia, Experimental / Q000097:blood / Q000276:immunology; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011925:Rauscher Virus
D002791:Cholesterol, Dietary; D008055:Lipids; D008074:Lipoproteins
Immunooposredovannaia induktsiia giperlipoproteidemii.