title: Production of superoxide anion by bovine pulmonary macrophages challenged with soluble and particulate stimuli.
abstract: The effects of opsonized zymosan, phorbal myristate acetate, and live Pasteurella haemolytica on superoxide anion production by bovine pulmonary macrophages were determined. The anion responses were dose-dependent for all stimuli, except for unopsonized P haemolytica. The effect of viable P haemolytica on macrophage viability was related to bacterial dosage and the presence of opsonizing antibody. Superoxide responses varied directly with the dose of opsonized live P haemolytica, but indirectly with macrophage viability.
authors.forename: R M
authors.initials: RM
authors.lastname: Dyer
authors.forename: C E
authors.initials: CE
authors.lastname: Benson
authors.forename: M G
authors.initials: MG
authors.lastname: Boy
mesh_terms: D000818:Animals; D002417:Cattle; D003124:Colorimetry; D007106:Immune Sera / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010325:Pasteurella / Q000502:physiology*; D010704:Phorbols / Q000494:pharmacology*; D011650:Pulmonary Alveoli / Q000166:cytology; D013481:Superoxides / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D015054:Zymosan / Q000494:pharmacology*
chemical_list: D007106:Immune Sera; D010704:Phorbols; D013481:Superoxides; D015054:Zymosan; D013755:Tetradecanoylphorbol Acetate