Thio-analogues of inorganic pyrophosphate inhibit the replication of influenza virus A in vitro.
Mono- and bisthiopyrophosphate can inhibit the replication of influenza virus A/X49 in Madin-Darby canine kidney (MDCK) cells at concentrations at which no cytotoxic effect is observed after 3 days. The thiopyrophosphate analogues inhibit the RNA transcriptase activity of this virus possibly by chelating with an essential metal ion in the transcriptase complex. [31P]NMR spectroscopy indicates that bisthiopyrophosphate coordinates to zinc through sulphur and magnesium through oxygen which may influence the inhibitory properties of this compound with metal-containing enzymes.
Hutchinson
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Naylor
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Cullis
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D000998:Antiviral Agents / Q000494:pharmacology*; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors; D011756:Diphosphates / Q000494:pharmacology*; D009980:Influenza A virus / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D011756:Diphosphates; C046011:bis(thiopyrophosphoric acid); C046010:monothiopyrophosphoric acid; D012321:DNA-Directed RNA Polymerases