The Drosophila EGF receptor gene homolog: conservation of both hormone binding and kinase domains.
Chicken v-erB probe was used to isolate a unique clone of Drosophila melanogaster DNA. It maps by in situ hybridization to position 57F on chromosome 2. A complete nucleotide sequence of the coding region has been obtained. The putative Drosophila EGF receptor protein is similar in overall organization to the human homolog. It shows three distinct domains: an extracellular putative EGF binding domain, a hydrophobic transmembrane region, and a cytoplasmic kinase domain. The overall amino acid homology is 41% in the extracellular domain and 55% in the kinase domain. Two cysteine-rich regions, a hallmark of the human ligand-binding domain, have also been conserved. Fusion of the coding sequences of the kinase and extracellular domains generating the receptor gene must have occurred over 800 million years ago.
Livneh
E
E
Glazer
L
L
Segal
D
D
Schlessinger
J
J
Shilo
B Z
BZ
D000595:Amino Acid Sequence; D000818:Animals; D001435:Bacteriophages / Q000235:genetics; D001483:Base Sequence; D005075:Biological Evolution; D002645:Chickens / Q000235:genetics; D002874:Chromosome Mapping; D003593:Cytoplasm; D004274:DNA, Recombinant; D004331:Drosophila melanogaster / Q000235:genetics*; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors; D006801:Humans; D009693:Nucleic Acid Hybridization; D010766:Phosphorylation; D011494:Protein Kinases / Q000235:genetics*; D011505:Protein-Tyrosine Kinases; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism
D004274:DNA, Recombinant; D011956:Receptors, Cell Surface; D004815:Epidermal Growth Factor; D011494:Protein Kinases; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases