Studies of the putative transforming protein of the type I human T-cell leukemia virus.
The putative transforming protein of the type I human T-cell leukemia virus (HTLV-1) is a 40-kilodalton protein encoded by the X region and is termed p40XI. On the basis of both subcellular fractionation techniques and immunocytochemical analysis, it is now shown that p40XI is a nuclear protein with a relatively short half-life (120 minutes). It is synthesized de novo in considerable quantities in a human T-cell line infected with and transformed by the virus in vitro, and it is not packaged in detectable amounts in the extracellular virus.
Slamon
D J
DJ
Press
M F
MF
Souza
L M
LM
Murdock
D C
DC
Cline
M J
MJ
Golde
D W
DW
Gasson
J C
JC
Chen
I S
IS
D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor / Q000276:immunology / Q000378:metabolism*; D002458:Cell Fractionation; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism; D002472:Cell Transformation, Viral; D017977:Deltaretrovirus / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007106:Immune Sera; D011233:Precipitin Tests; D014764:Viral Proteins / Q000276:immunology / Q000378:metabolism*
D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor; D007106:Immune Sera; D014764:Viral Proteins