title: [Suppressor T cell function in undifferentiated collagenoses].
abstract: In order to study early cellular defects in connective tissue diseases, suppressor T-cell function in undifferentiated connective tissue syndromes was determined. The capacity of T8(CD8)-positive cells to suppress pokeweed mitogen-induced IgG and IgM secretion was studied in 14 patients. Compared with normals, a reduced activity of cells to suppress the IgM response was shown, whereas the suppression of IgG secretion was not affected.
authors.affiliation: III. Medizinische Klinik u. Poliklinik, Justus-Liebig-Universität Giessen.
authors.forename: H
authors.initials: H
authors.lastname: Becker
authors.forename: E
authors.initials: E
authors.lastname: Würden
authors.forename: K
authors.initials: K
authors.lastname: Helmke
mesh_terms: D000328:Adult; D003095:Collagen Diseases / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M
vernacular_title: Suppressor-T-Zell-Funktion bei undifferenzierten Kollagenosen.