Use of primate folliculogenesis models in understanding human reproductive biology and applicability to toxicology.
The nonhuman primate reproductive system provides an excellent model for studying basic physiological processes applicable to humans. This article reviews hormonal observations and experimental manipulations useful in the evaluation of ovarian events in various stages of the reproductive life. As the need arises, primate reproductive toxicological studies may clarify questions relevant to human risk evaluations. Evaluation of reproductive toxicological observations may reveal biological parameters defining premature reproductive failure.
Sakai
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Reproductive Effects Assessment Group, Office of Health and Environmental Assessment, U.S. Environmental Protection Agency, Washington, D.C. 20460.
Hodgen
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GD
D000818:Animals; D005260:Female; D006801:Humans; D008954:Models, Biological; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology*; D011323:Primates / Q000502:physiology*; D012098:Reproduction / Q000187:drug effects / Q000502:physiology*; D012107:Research Design