In vitro inhibition of human herpesvirus-6 by phosphonoformate.
HSB-2 cell cultures productively infected with human herpesvirus-6 were treated with the antiviral drugs phosphonoformic acid (PFA), acyclovir (ACV), and gancyclovir (DHPG). ACV and DHPG showed significant toxic effects on uninfected HSB-2 cells, yet only incompletely inhibited viral expression upon infection of the cells. PFA, however, showed little direct toxicity on HSB-2 cells while viral replication was inhibited significantly.
Streicher
H Z
HZ
National Cancer Institute, Bethesda, Maryland 20892.
Hung
C L
CL
Ablashi
D V
DV
Hellman
K
K
Saxinger
C
C
Fullen
J
J
Salahuddin
S Z
SZ
D000212:Acyclovir / Q000031:analogs & derivatives / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D017245:Foscarnet; D015774:Ganciclovir; D006564:Herpesviridae / Q000187:drug effects*; D006801:Humans; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*
D000998:Antiviral Agents; D009943:Organophosphorus Compounds; D017245:Foscarnet; D010746:Phosphonoacetic Acid; D015774:Ganciclovir; D000212:Acyclovir