title: Adenovirus type 2 encephalitis and concurrent Epstein-Barr virus infection in an adult man.
abstract: A 30-year-old bisexual male prisoner with a history of intravenous drug abuse manifested encephalitis. Adenovirus type 2 was isolated from brain tissue obtained by a biopsy and there was a concurrent fourfold rise in the antibody titer. In addition, an initial negative result from a slide test for infectious mononucleosis heterophil antibodies (Monospot) test converted to positive and there was an increase in the IgG antibody titer to Epstein-Barr virus (EBV) viral capsid antigen. Although he was anergic to skin test antigens, T-cell subsets and lymphocyte transformation study results were normal. This case demonstrated a rare adenovirus encephalitis with a simultaneous EBV infection in a patient at risk for acquired immunodeficiency syndrome, who had minimal evidence of T-cell deficiency.
authors.forename: T E
authors.initials: TE
authors.lastname: West
authors.forename: C J
authors.initials: CJ
authors.lastname: Papasian
authors.forename: B H
authors.initials: BH
authors.lastname: Park
authors.forename: S W
authors.initials: SW
authors.lastname: Parker
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D000257:Adenoviridae Infections / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D004660:Encephalitis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D004854:Herpesvirus 4, Human; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D008297:Male
chemical_list: D000914:Antibodies, Viral