title: [Gamma-aminobutyric acid metabolism in the rat brain after administration of nootropic agents].
abstract: N,N-bis-pyrrolidonomethyl-diaza - 18-crown-6 and piracetam, which are structural analogues of gamma-aminobutyric acid (GABA) and exhibit nootropic properties, affected the GABA metabolism, the content of total protein, DNA and RNA in rat brain after long-term administration at pharmacologically active doses of 100 mg/kg and 400 mg/kg, respectively. As compared with control values, content of GABA in rat brain was increased by 40% after administration of N,N-bis-pyrrolodonomethyl-diaza-18-crown-6 and by 28%--after treatment with piracetam. At the same time, activity of GABA transaminase was decreased by 49.4% and 39.8%, respectively, while the decarboxylase activity was unaltered.
authors.forename: T L
authors.initials: TL
authors.lastname: Karaseva
authors.forename: Zh N
authors.initials: ZhN
authors.lastname: Tsapenko
authors.forename: N Ia
authors.initials: NIa
authors.lastname: Golovenko
authors.forename: S E
authors.initials: SE
authors.lastname: Timofeeva
authors.forename: N G
authors.initials: NG
authors.lastname: Luk'ianenko
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004988:Ethers, Cyclic / Q000494:pharmacology*; D005968:Glutamate Decarboxylase / Q000378:metabolism; D008297:Male; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D004988:Ethers, Cyclic; D011760:Pyrrolidinones; D005680:gamma-Aminobutyric Acid; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase; D010889:Piracetam
vernacular_title: Obmen gamma-aminomaslianoĭ kisloty v golovnom mozge krys v usloviiakh vvedeniia im nootropnykh sredstv.