title: Nuclear ADP-ribosylation in the chick lens during embryonic development.
abstract: Nuclear ADP-ribosyltransferase is present in cells from the chick lens throughout embryonic development. The activity does not decrease when the cells become post-mitotic and commence terminal differentiation but declines slowly in both epithelia and fibre cells. At all stages studied the enzyme retains its ability to be activated by DNA strand breaks induced either by X-irradiation or by the action of an endogenous endonuclease. There is no correlation between the enzyme activity or the levels of its substrate NAD+ and the changes in DNA repair capacity which have been observed during the development of the lens.
authors.forename: M F
authors.initials: MF
authors.lastname: Counis
authors.forename: E
authors.initials: E
authors.lastname: Chaudun
authors.forename: Y
authors.initials: Y
authors.lastname: Courtois
authors.forename: C J
authors.initials: CJ
authors.lastname: Skidmore
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000201:enzymology*; D002642:Chick Embryo; D004260:DNA Repair; D007908:Lens, Crystalline / Q000196:embryology / Q000201:enzymology* / Q000528:radiation effects; D009243:NAD / Q000378:metabolism; D009713:Nucleotidyltransferases / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases
chemical_list: D009243:NAD; D011065:Poly(ADP-ribose) Polymerases; D009713:Nucleotidyltransferases