[Atrial natriuretic peptides. III. Synthesis and biological activity of alpha-r-ANP, APII, APIII and des-Ser5,Ser6-APII].
A series of atrial natriuretic peptides, viz., alpha-r-ANF, APII, APIII, and des-Ser5, Ser6-APII, have been obtained by condensation of earlier synthesized fragments promoted with complex F. Acetylaminomethyl protecting group were removed from cystein residues with simultaneous cyclization of the peptide. Biological activity of the atrial natriuretic peptides was studied.
Ovchinnikov
M V
MV
Bespalova
Zh D
ZhD
Molokoedov
A S
AS
Titov
M I
MI
Revenko
I V
IV
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D014664:Vasodilation / Q000187:drug effects
D010446:Peptide Fragments; C057734:atrial natriuretic factor, des-Ser(5)-Ser(6)-; D009320:Atrial Natriuretic Factor; C057733:atrial natriuretic factor (5-27); C054538:atrial natriuretic factor (5-28)
Atrial'nye natriĭureticheskie peptidy. III. Sintez i izuchenie biologicheskoĭ aktivnosti alpha-r-ANP, APII, APIII i des-Ser5,Ser6-APII.