title: Induction of sister-chromatid exchanges by restriction endonucleases.
abstract: Restriction endonucleases Cfo 1, Pvu II, Sma I, Hpa II, Taq I and Hae III were tested for their ability to induce SCEs in CHO cells. The results indicate that the DNA double-strand breaks induced during S-phase by these enzymes lead to an increase in the frequencies of SCEs.
authors.forename: A T
authors.initials: AT
authors.lastname: Natarajan
authors.forename: L H
authors.initials: LH
authors.lastname: Mullenders
authors.forename: M
authors.initials: M
authors.lastname: Meijers
authors.forename: U
authors.initials: U
authors.lastname: Mukherjee
mesh_terms: D000818:Animals; D002460:Cell Line; D002875:Chromosomes / Q000187:drug effects / Q000648:ultrastructure; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000378:metabolism; D004262:DNA Restriction Enzymes / Q000494:pharmacology*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000648:ultrastructure; D010053:Ovary; D012854:Sister Chromatid Exchange / Q000187:drug effects*
chemical_list: D004247:DNA; D004262:DNA Restriction Enzymes