[Evidence for several storage and exportation pathways of pancreatic digestive enzymes during protein malnutrition followed by refeeding].
Outputs of pancreatic juice hydrolase were constant during a three-hour collection in control rats fed 20% protein and in malnourished rats fed on a low protein diet (5% protein). However, during the same time after a 3H-Leucine pulse, the relative proportion of each labelled enzyme (newly synthesized) were changed. In control rats, this phenomenon was specially obvious for trypsinogen 2 (Tg2) and chymotrypsinogen 1 (Chtg1), and support the existence of separate pools for various pancreatic hydrolases. In malnourished rats, the relative proportion of labelled Tg2 is not modified by protein malnutrition, whereas the proportion of labelled amylase, lipase and Chtg1 were decreased. Refeeding carried out the same labelling profile of each enzyme in the two groups.
Prost
J
J
Université de Bourgogne, Laboratoire de Physiologie Animale et de la Nutrition, Dijon.
Belleville
J
J
D000818:Animals; D002919:Chymotrypsinogen / Q000378:metabolism; D005502:Food; D006867:Hydrolases / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism; D010189:Pancreatic Juice / Q000201:enzymology*; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011502:Protein-Energy Malnutrition / Q000201:enzymology*; D051381:Rats; D014362:Trypsinogen / Q000378:metabolism
C000717609:Tgm2 protein, rat; D014362:Trypsinogen; D002919:Chymotrypsinogen; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D006867:Hydrolases; D007930:Leucine
Mise en évidence de plusieurs voies de stockage et d'exportation des enzymes digestives pancréatiques au cours d'une malnutrition protéique suivie d'une réalimentation équilibrée.