Gene dosage effect in cells with monosomy of chromosome 22 derived from human meningiomas.
Enzymatic determinations of four enzymes, Arylsulphatase A (ARSA), alpha-iduronidase (IDUA), beta-galactosidase (GLB) and hexosaminidase were performed in 19 cases of meningioma. Gene dosage effect was demonstrated for ARSA and IDUA; preliminary evidence for mapping a "protective protein" of GLB in the region 22pter----q11 was also obtained.
Casalone
R
R
Biologia generale e Genetica Medica, Università di Pavia, Italy.
Minelli
A
A
Butti
G
G
Gaetani
P
P
Silvani
V
V
Solero
C L
CL
Danesino
C
C
D001192:Arylsulfatases / Q000032:analysis / Q000235:genetics; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D007068:Iduronidase / Q000032:analysis / Q000235:genetics; D008577:Meningeal Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D008579:Meningioma / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D009006:Monosomy; D014407:Tumor Cells, Cultured; D001616:beta-Galactosidase / Q000032:analysis / Q000235:genetics; D001619:beta-N-Acetylhexosaminidases / Q000032:analysis / Q000235:genetics
D001192:Arylsulfatases; D001616:beta-Galactosidase; D001619:beta-N-Acetylhexosaminidases; D007068:Iduronidase