Comparative investigation of antipyrine half-life and induction of cytochrome P-450 dependent monooxygenases in rats treated with phenylurea herbicides.
The short-term effect of three substituted phenylurea herbicides has been investigated on antipyrine plasma half-life in rats. Isoproturon was ineffective, while chlortoluron and diuron decreased the half-life significantly. There was a close correlation between antipyrine half-lives and induction of hepatic cytochrome P-450 dependent benzo(a)pyrene monooxygenase, 7-ethoxycoumarin O-deethylase and 7-ethoxyresorufin O-deethylase.
Schoket
B
B
Department of Biochemistry, National Institute of Hygiene, Budapest, Hungary.
Zilahy
Z
Z
Molnar
J
J
Vincze
I
I
D000818:Animals; D000983:Antipyrine / Q000097:blood*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction; D006207:Half-Life; D006540:Herbicides / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D010671:Phenylurea Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D006540:Herbicides; D010671:Phenylurea Compounds; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D000983:Antipyrine