[Changes in the physico-chemical properties of synaptosomal membranes induced by phospholipase A2].
Using fluorescent and EPR spin probing techniques, the changes in the physico-chemical properties of rat brain synaptosomal membranes induced by phospholipase A2 were studied. It was shown that treatment of synaptosomal membranes with phospholipase A2 leads to their depolarization, increases their surface negative potential and decreases the microviscosity of the membrane lipid bilayer. The observed changes in the physicochemical properties of synaptosomal membranes induced by phospholipase A2 are discussed in terms of a possible regulatory role of lipids in the transmembrane chemical signal transfer.
Erin
A N
AN
Tiurin
V A
VA
Brusovanik
V I
VI
Gorbunov
N V
NV
Selishcheva
A A
AA
D000818:Animals; D001921:Brain / Q000502:physiology* / Q000648:ultrastructure; D004578:Electron Spin Resonance Spectroscopy; D008560:Membrane Fluidity; D008564:Membrane Potentials; D010740:Phospholipases / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism / Q000502:physiology*
D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2
Izmenenie fiziko-khimicheskikh parametrov membran sinaptosom pod deĭstviem fosfolipazy A2.