title: High continuous antimony therapy in two patients with unresponsive mucosal leishmaniasis.
abstract: The treatment of two patients with severe mucosal leishmaniasis due to Leishmania braziliensis braziliensis is described. Both patients had received much prior antimonial therapy and one had relapsed after a total dose of 2.5 g of Amphotericin B. Both patients responded to prolonged continuous Pentostam therapy at a daily dose of 20 mg Sbv/kg/day for 62 days in one case and for 85 days in the other. Pentavalent antimonials can be curative in such protracted courses in selected patients unresponsive to standard chemotherapy.
authors.forename: P D
authors.initials: PD
authors.lastname: Marsden
authors.forename: R N
authors.initials: RN
authors.lastname: Sampaio
authors.forename: E M
authors.initials: EM
authors.lastname: Carvalho
authors.forename: J P
authors.initials: JP
authors.lastname: Veiga
authors.forename: J L
authors.initials: JL
authors.lastname: Costa
authors.forename: E A
authors.initials: EA
authors.lastname: Llanos-Cuentas
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000965:Antimony / Q000627:therapeutic use; D000967:Antimony Sodium Gluconate / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D005942:Gluconates / Q000627:therapeutic use*; D006801:Humans; D007897:Leishmaniasis, Mucocutaneous / Q000188:drug therapy*; D008297:Male; D008536:Meglumine; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds
chemical_list: D005942:Gluconates; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate; D000666:Amphotericin B; D000965:Antimony; D000967:Antimony Sodium Gluconate