[Inhibiting effect of a chalone-containing extract of calf pancreatic tissue on the proliferative activity of normal and tumorous pancreatic cells in vitro and in vivo].
The pancreatic chalone has been studied for its effect on the proliferative activity and morphology of normal and tumour cells of the pancreas. These findings in experiments in vitro were confirmed by the data of the in vivo experiments. The results show that pancreatic chalone inhibits cell proliferation, decreases mitotic index and causes morphologic changes in cultivated pancreatic cells.
Mkrtchian
L N
LN
Khachaturova
T S
TS
Shukurian
S G
SG
Aleksanian
K A
KA
Melik-Shakhnazarian
R B
RB
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003864:Depression, Chemical; D004353:Drug Evaluation, Preclinical; D006131:Growth Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008938:Mitosis / Q000187:drug effects; D010179:Pancreas / Q000166:cytology / Q000187:drug effects*; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006131:Growth Inhibitors
Ingibiruiushchiĭ éffekt keĭlonosoderzhashchego ékstrakta iz tkani podzheludochnoĭ zhelezy teliat na proliferativnuiu aktivnost' normal'nykh i opukholevykh kletok podzheludochnoĭ zhelezy in vitro i in vivo.