Influence of hydrochlorothiazide on the pain threshold and on the antinociceptive activity of morphine, in rats.
Hydrochlorothiazide, acutely injected in rats, has a weak analgesic activity per se and potentiates and prolongs the antinociceptive effect of morphine.
Poggioli
R
R
Vergoni
A V
AV
Bertolini
A
A
D000818:Animals; D004357:Drug Synergism; D006852:Hydrochlorothiazide / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology; D012964:Sodium / Q000502:physiology
D011957:Receptors, Opioid; D006852:Hydrochlorothiazide; D009020:Morphine; D012964:Sodium