title: Pain in peripheral arteriography: an assessment of conventional versus ionic and non-ionic low-osmolality contrast agents.
abstract: Two low-osmolality contrast agents, ioxaglate meglumine/sodium and iohexol were compared with diatrizoate meglumine/sodium in a controlled double blind study of 126 patients undergoing arteriography for peripheral vascular disease to determine which caused the least pain. Discomfort was assessed by means of a visual analog scale rating pain from 0 to 100. Average values for pain were 39 +/- 27 for diatrizoate, 14 +/- 15 for ioxaglate and 21 +/- 22 for iohexol. We found that both low-osmolality agents caused significantly less pain in peripheral arteriography than the traditional agent. The p values were p less than 0.0005 for ioxaglate and p less than 0.005 for iohexol versus diatrizoate. In addition, ioxaglate was found to cause significantly less pain than iohexol (p less than 0.05) in this patient group.
authors.affiliation: Department of Radiology, Victoria General Hospital, Halifax, Nova Scotia.
authors.forename: G
authors.initials: G
authors.lastname: Murphy
authors.forename: D R
authors.initials: DR
authors.lastname: Campbell
authors.forename: D B
authors.initials: DB
authors.lastname: Fraser
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000009:adverse effects*; D003974:Diatrizoate Meglumine / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007472:Iohexol / Q000009:adverse effects; D007485:Ioxaglic Acid / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D010146:Pain / Q000139:chemically induced*; D011897:Random Allocation
chemical_list: D003287:Contrast Media; D003974:Diatrizoate Meglumine; D007472:Iohexol; D007485:Ioxaglic Acid