rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1.
The Rpt-1 (for regulatory protein, T-lymphocyte, 1) gene, selectively expressed by resting but not by activated CD4+ inducer T cells, encodes an intracellular protein (rpt-1, Mr 41,000) that down-regulates gene expression directed by the promoter region of the gene encoding interleukin 2 receptor alpha chain and by the long terminal repeat of human immunodeficiency virus type 1. The data reported here suggest that rpt-1 levels may be inversely correlated with activation of CD4+ T cells and human immunodeficiency virus replication leading to clinical symptoms of the acquired immunodeficiency syndrome.
Patarca
R
R
Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA.
Freeman
G J
GJ
Schwartz
J
J
Singh
R P
RP
Kong
Q T
QT
Murphy
E
E
Anderson
Y
Y
Sheng
F Y
FY
Singh
P
P
Johnson
K A
KA
D000163:Acquired Immunodeficiency Syndrome / Q000503:physiopathology; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D004268:DNA-Binding Proteins / Q000502:physiology*; D005786:Gene Expression Regulation; D005796:Genes; D005809:Genes, Regulator; D005814:Genes, Viral; D006678:HIV / Q000235:genetics*; D006801:Humans; D008213:Lymphocyte Activation; D051379:Mice; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D011487:Protein Conformation; D011971:Receptors, Immunologic / Q000235:genetics*; D015375:Receptors, Interleukin-2; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
D004268:DNA-Binding Proteins; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D014157:Transcription Factors; C055548:Trim30a protein, mouse