Fenretinide does not block visual pigment formation in the rat.
Abnormal retinal function has been reported in patients receiving the synthetic retinoid fenretinide. In this study, the vitamin A deprived rat was used as a model to test the possibility that fenretinide is interfering with the vitamin A transport system and/or blocking the normal uptake of 11-cis retinal into the visual pigment. Assessing retinal function by electroretinogram measurements and visual pigment formation by competition studies, our data demonstrate normal uptake of vitamin A and normal visual pigment formation in the rat after treatment with the drug.
Crouch
R K
RK
Department of Ophthalmology, Medical University of South Carolina, Charleston.
Goletz
P
P
D000818:Animals; D002417:Cattle; D005136:Eye Proteins / Q000378:metabolism; D017313:Fenretinide; D010786:Photoreceptor Cells / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012168:Retinal Pigments / Q000096:biosynthesis*; D012172:Retinaldehyde / Q000378:metabolism; D012243:Rhodopsin / Q000096:biosynthesis*; D017299:Rod Opsins; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014801:Vitamin A / Q000378:metabolism
D005136:Eye Proteins; D012168:Retinal Pigments; D017299:Rod Opsins; D014801:Vitamin A; D017313:Fenretinide; D014212:Tretinoin; D012243:Rhodopsin; D012172:Retinaldehyde