title: Infantile glaucoma in Down's syndrome (trisomy 21).
abstract: We examined five patients with Down's syndrome and bilateral infantile glaucoma. In the first few months of life four patients had large cloudy corneas, breaks in Descemet's membrane, increased intraocular pressure, photophobia, and tearing. In one patient the diagnosis was delayed until 3 1/2 years of age because of concomitant nasolacrimal duct obstruction. Two patients developed cataracts and retinal detachment and have undergone multiple surgical procedures. The clinical course in these two older patients suggests that coexistence of congenital glaucoma, severe myopia, and cataracts in patients with trisomy 21 strongly predisposes for the development of retinal detachment and poor visual outcome.
authors.affiliation: Center for Sight, Georgetown University Medical Center, Washington, D.C. 20007.
authors.forename: E I
authors.initials: EI
authors.lastname: Traboulsi
authors.forename: E
authors.initials: E
authors.lastname: Levine
authors.forename: M B
authors.initials: MB
authors.lastname: Mets
authors.forename: E S
authors.initials: ES
authors.lastname: Parelhoff
authors.forename: J F
authors.initials: JF
authors.lastname: O'Neill
authors.forename: D E
authors.initials: DE
authors.lastname: Gaasterland
mesh_terms: D000293:Adolescent; D000328:Adult; D002386:Cataract / Q000150:complications; D003315:Cornea / Q000473:pathology; D004200:Diseases in Twins; D004314:Down Syndrome / Q000150:complications* / Q000473:pathology; D005260:Female; D005901:Glaucoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D012030:Refractive Errors / Q000150:complications; D012163:Retinal Detachment / Q000150:complications; D014130:Trabeculectomy