Transferrin receptors in cultured breast cancer cells.
Transferrin receptors were demonstrated on the cell membrane of breast cancer epithelial cells in primary or long-term culture. Diferric transferrin binding was saturable, specific and was not related to DNA content or clinical and histological features of the tumour. However a good correlation (p less than 0.01) was found between transferrin binding and thymidine incorporation. These results suggest the possibility of transferrin receptor measurement as a reflection of the proliferative activity of cultured breast tumour cells.
Vandewalle
B
B
Granier
A M
AM
Peyrat
J P
JP
Bonneterre
J
J
Lefebvre
J
J
D001943:Breast Neoplasms / Q000032:analysis*; D002478:Cells, Cultured; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005260:Female; D006801:Humans; D011956:Receptors, Cell Surface / Q000032:analysis*; D011990:Receptors, Transferrin; D013936:Thymidine / Q000378:metabolism
D004273:DNA, Neoplasm; D011956:Receptors, Cell Surface; D011990:Receptors, Transferrin; D013936:Thymidine