Sensory neuropathy with low-dose pyridoxine.
We describe 16 patients with neuropathy associated with pyridoxine abuse. The clinical picture of a pure sensory central-peripheral distal axonopathy was consistent. Pyridoxine dose was 0.2 to 5 g/d, and duration of consumption before symptoms was inversely proportional to the daily intake. In all patients with adequate follow-up, improvement followed discontinuation of pyridoxine. The ready availability of up to 1-gram tablets makes it likely that this neuropathy will continue to be seen.
Parry
G J
GJ
Bredesen
D E
DE
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D011736:Pyridoxine / Q000009:adverse effects*; D012677:Sensation; D019966:Substance-Related Disorders / Q000503:physiopathology
D011736:Pyridoxine