Partial agonists of the morphine type: facilitative effects on electrophysiologically recorded C-fiber reflexes in the cat.
The purpose of the present study was to examine the effects of the partial agonists of the morphine type, buprenorphine, profadol and propiram on the spinally-mediated C-fiber reflex. Buprenorphine, profadol and propiram facilitated the C-fiber reflex. In the presence of naltrexone, the effects of buprenorphine were changed to depression of the C-fiber reflex. Profadol and propiram continued to facilitate the C-fiber reflex in the presence of naltrexone. The present results suggest that buprenorphine facilitated the C-fiber reflex by blocking endogenous opioid peptide inhibition of the C-fiber reflex whereas profadol and propiram facilitated it by a non-opioid mechanism.
Bell
J A
JA
National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224.
Shannon
H E
HE
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002047:Buprenorphine / Q000494:pharmacology*; D002415:Cats; D003655:Decerebrate State; D005260:Female; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*
D000700:Analgesics; D011725:Pyridines; D011759:Pyrrolidines; D002047:Buprenorphine; C002107:propiram