Renal hypertrophy in experimental diabetes: some functional aspects.
Glomerular filtration rate (GFR) was measured by constant infusion of iothalamate in conscious rats with and without streptozotocin diabetes. Kidney weight had already increased significantly after 4 days of diabetes. GFR was unchanged at that time, but increased subsequently, so that GFR/kidney weight was normal after 1 month of diabetes. Tubular glucose reabsorption rate was increased to the same extent as kidney weight after 4 days of diabetes. It is concluded that renal growth in experimental diabetes cannot be initiated by glomerular hyperfiltration, but that increased glucose reabsorption may have a causal role.
Seyer-Hansen
K
K
Department of Internal Medicine, Svendborg Hospital, Denmark.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate; D005947:Glucose / Q000378:metabolism; D006984:Hypertrophy; D007483:Iothalamic Acid; D007668:Kidney / Q000473:pathology / Q000503:physiopathology*; D007687:Kidney Tubules, Proximal / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D007483:Iothalamic Acid; D005947:Glucose