Normal free fatty acid response to isoproterenol in pseudohypoparathyroidism.
The lipolytic response to isoproterenol infusion was examined in seven normal subjects and six patients with pseudohypoparathyroidism type I [two had deficiency of the hormone receptor-cyclase coupling protein (N-protein) and four did not]. Despite blunted plasma cAMP responses to isoproterenol in both subgroups of pseudohypoparathyroidism patients, the serum FFA responses were normal. We conclude that changes in plasma cAMP do not reflect the adequacy of the lipolytic response to isoproterenol.
Carlson
H E
HE
Brickman
A S
AS
Burns
T W
TW
Langley
P E
PE
D000328:Adult; D000242:Cyclic AMP / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006801:Humans; D007263:Infusions, Parenteral; D007545:Isoproterenol / Q000494:pharmacology*; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011547:Pseudohypoparathyroidism / Q000097:blood*
D005230:Fatty Acids, Nonesterified; D000242:Cyclic AMP; D007545:Isoproterenol