Modulation by RU 41740 of oxidative metabolism and migration of rat polymorphonuclear leukocytes collected after induction of immune and nonimmune inflammations.
The activity of an immunomodulating agent, RU 41740, on the behavior of polymorphonuclear leukocytes (PMNs) elicited by two models of inflammation was studied. We observed the effect produced on migration and oxidative metabolism after incubation in vitro, in various drug concentrations, or administration in vivo. A stimulation of oxidative metabolism and an inhibition of chemotaxis was observed with the two types of PMNs. However Arthus-elicited PMNs were less reactive. This might be related to a nonspecific deactivation of the cells after induction of such an immune inflammatory reaction. This evidenced that PMN reactivity greatly varies with the physiopathological state of the cells.
Roch-Arveiller
M
M
Département de Pharmacologie, UA CNRS 595, Hôpital Cochin, Paris, France.
Abbouyi
A E
AE
Paul
J L
JL
Smets
P
P
Raichvarg
D
D
Giroud
J P
JP
D000818:Animals; D001183:Arthus Reaction / Q000276:immunology / Q000378:metabolism; D001426:Bacterial Proteins / Q000494:pharmacology*; D002131:Calcium Pyrophosphate / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D066298:In Vitro Techniques; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D008297:Male; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D001426:Bacterial Proteins; C037567:glycoprotein, Klebsiella pneumoniae; D002131:Calcium Pyrophosphate