p,p'-DDT-induced myoclonus in mice: the effect of enhanced 5-HT neurotransmission.
The acute behavioural consequences of intragastric p,p'-DDT in high doses to mice are stimulus sensitive abrupt muscle jerks (myoclonus). The serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) ameliorated in contrast to the natural precursor tryptophan, the neurotoxin-induced myoclonus. The extracerebral decarboxylase inhibitor carbidopa and the selective 5-HT reuptake inhibitor paroxetine both enhanced the antimyoclonic action of 5-HTP. The effect was reversed by the 5-HT receptor blockers cinanserine and methysergide. The data add further evidence to a central serotonergic mechanism involved in p,p'-DDT induced myoclonus.
Magnussen
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D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D002230:Carbidopa / Q000494:pharmacology; D003634:DDT / Q000633:toxicity*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009207:Myoclonus / Q000139:chemically induced*; D017374:Paroxetine; D010880:Piperidines / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects*; D014364:Tryptophan / Q000494:pharmacology
D010880:Piperidines; D012701:Serotonin; D017374:Paroxetine; D014364:Tryptophan; D006916:5-Hydroxytryptophan; D003634:DDT; D002230:Carbidopa