title: Adenocarcinoma of the extrahepatic biliary tree.
abstract: Increasing survival rates for carcinoma of the biliary tree could reflect the selection of patients for referral to a specialist centre as well as modern improvements in diagnosis and treatment. To determine the true incidence and outcome of biliary cancer, the records of 243 unselected Bristol patients were reviewed retrospectively over a 15-year period. Mean age was 64 years. Gallstones were associated in 38% of cases. Sixty-nine of 87 patients with gallbladder carcinoma were submitted to laparotomy. The operative (30-day) mortality rate was 56% and the one-year survival rate was 7%; one patient with an unexpected carcinoma is alive 7 years after cholecystectomy (1% five-year survival rate). Among 31 patients with carcinoma of the ampulla the operative mortality rate was 27%; one-year and five-year survival rates were 46% and 15%. Bile duct cancers (n = 125) arose proximal to the entry of the cystic duct (n = 63), distal to that point (n = 46) or diffusely (n = 16). For proximal cholangiocarcinoma the operative mortality rate was 38% and 1-year survival rate 17%; no patient lived for 2 years. For distal cholangiocarcinoma the operative mortality rate was 45% and one-year survival rate 26%; no patient lived for 3 years. Only palliative procedures were undertaken for diffuse cholangiocarcinoma; 2 patients survived 1 year (13%). Overall 5 patients with carcinoma of the extrahepatic biliary tree appear to have been cured (2%).
authors.forename: J B
authors.initials: JB
authors.lastname: Anderson
authors.forename: M J
authors.initials: MJ
authors.lastname: Cooper
authors.forename: R C
authors.initials: RC
authors.lastname: Williamson
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D002759:Adenoma, Bile Duct / Q000601:surgery; D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000601:surgery; D001650:Bile Duct Neoplasms / Q000601:surgery; D001661:Biliary Tract Neoplasms / Q000473:pathology / Q000601:surgery*; D003138:Common Bile Duct Neoplasms / Q000601:surgery; D005260:Female; D005706:Gallbladder Neoplasms / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies