title: Immunological abnormalities of acquired immunodeficiency syndrome and related disorders in patients from Rio de Janeiro, Brazil.
abstract: The immunological profile of acquired immunodeficiency syndrome (AIDS) and chronic lymphadenopathy syndrome (CLAS) in 15 and 11 Brazilian patients, respectively, was studied. The AIDS patients showed reduced percentage of total T (CD3) and T-helper-inducer (CD4) lymphocytes, relative increase in numbers of T-suppressor-cytotoxic (CD8) cells and a marked inversion of T-helper-inducer/suppressor-cytotoxic (CD4/CD8) ratio. Lymphoproliferative responses to PHA, ConA, PPD and PWM were diminished. Hypergammaglobulinemia and high levels of circulating immune complexes were also found. The CLAS patients also showed important immunological alterations, but not so intense as those with AIDS. These data seems to be similar to those observed in other parts of the world.
authors.affiliation: Instituto Oswaldo Cruz, Departamento de Imunologia-WHO Collaborating Centre of AIDS, Rio de Janeiro, Brasil.
authors.forename: W
authors.initials: W
authors.lastname: Miranda-Silva
authors.forename: B
authors.initials: B
authors.lastname: Galvão-Castro
authors.forename: M G
authors.initials: MG
authors.lastname: Bonecini-Almeida
authors.forename: C T
authors.initials: CT
authors.lastname: Daniel-Ribeiro
authors.forename: F S
authors.initials: FS
authors.lastname: Sion
authors.forename: C A
authors.initials: CA
authors.lastname: De Sá
mesh_terms: D000386:AIDS-Related Complex / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D001938:Brazil; D005260:Female; D006716:Homosexuality; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012725:Sexual Behavior; D013601:T-Lymphocytes / Q000032:analysis; D006377:T-Lymphocytes, Helper-Inducer / Q000032:analysis
chemical_list: D000936:Antigen-Antibody Complex; D007136:Immunoglobulins