Atrial natriuretic peptide and vasopressin in human plasma.
Using a specific radioimmunoassay for atrial natriuretic peptide (ANP), plasma immunoreactive ANP was measured in 17 normal subjects and 83 patients with various diseases. Plasma ANP concentration in normal subjects was 14.1 +/- 1.7 pg/ml (mean +/- S.E.). Relatively high plasma ANP concentrations were detected in patients with diabetes mellitus, hyperthyroidism, atrial fibrillation and liver cirrhosis. Plasma ANP concentrations in the patients correlated positively with mean arterial blood pressure and plasma AVP concentrations. Plasma ANP concentrations in the patients also had positive correlations with left atrial dimension and left ventricular diastolic dimension determined by echocardiography. Another positive correlation was observed in the patients between plasma AVP concentrations and mean arterial blood pressure. These results suggest that ANP is a volume regulatory hormone but also that ANP may be involved in the blood pressure regulating system.
Sakamoto
M
M
Second Department of Internal Medicine, Hamamatsu University School of Medicine, Japan.
Tanaka
I
I
Oki
Y
Y
Ikeda
Y
Y
Nanno
M
M
Yoshimi
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001127:Arginine Vasopressin / Q000097:blood*; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood*; D002850:Chromatography, Gel; D004700:Endocrine System Diseases / Q000097:blood*; D006339:Heart Rate; D006801:Humans; D066298:In Vitro Techniques; D008171:Lung Diseases / Q000097:blood*; D008297:Male; D008875:Middle Aged
D001127:Arginine Vasopressin; D009320:Atrial Natriuretic Factor