Sympathetic innervation of blood vessels in rats with aortic constriction hypertension.
The adrenergic innervation of blood vessel wall was studied in various vascular beds of adult rats with experimental hypertension induced by the constriction of the aorta between the origins of both renal arteries. A moderate expansion of body fluids was demonstrated in this hypertensive model. The decrease of the density of adrenergic plexus in the vessel wall as well as the diminished catecholamine fluorescence were found only in renal vessels. These changes were pronounced in the left renal artery and vein even if the left kidney was not subjected to elevated blood pressure. Thus the alteration of vascular adrenergic innervation in hypertensive rats is not a consequence of high blood pressure but it seems to be a part of neurohumoral pathogenetic mechanisms.
Kunes
J
J
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
Reidler
R M
RM
Leont'eva
G R
GR
Zicha
J
J
Jelínek
J
J
Govyrin
V A
VA
D000818:Animals; D001808:Blood Vessels / Q000294:innervation*; D002395:Catecholamines / Q000378:metabolism; D006978:Hypertension, Renovascular / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013564:Sympathetic Nervous System / Q000378:metabolism / Q000473:pathology*
D002395:Catecholamines