Formation of hydroxyl radicals from NADH and NADPH in the presence of copper salts.
The interaction of copper salts with NADH or NADPH in the presence of hydrogen peroxide at physiological pH is shown to produce hydroxyl radicals. The physiological significance of these results is discussed.
Rowley
D A
DA
Halliwell
B
B
D003300:Copper / Q000378:metabolism*; D006878:Hydroxides / Q000378:metabolism*; D017665:Hydroxyl Radical; D066298:In Vitro Techniques; D009243:NAD / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*
D006878:Hydroxides; D009243:NAD; D017665:Hydroxyl Radical; D009249:NADP; D003300:Copper