Maternal levels of pregnancy-specific beta 1-glycoprotein (SP-1) are elevated in pregnancies affected by Down's syndrome.
Concentrations of pregnancy-specific beta 1-glycoprotein (SP-1) were measured in maternal blood and amniotic fluid of patients with a trisomic fetus and compared with that of a cytogenetically normal fetus at weeks 16-19 of pregnancy. The SP-1 concentrations were significantly elevated in the sera of women with a Down's syndrome fetus, whereas amniotic fluid levels were only slightly increased. It is suggested that high levels of maternal SP-1 in the second trimester of pregnancy may be a valuable indicator in the prenatal detection of fetal trisomy 21.
Bartels
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I
Institut für Humangenetik der Universität, Göttingen, Federal Republic of Germany.
Lindemann
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A
D000653:Amniotic Fluid / Q000032:analysis; D004314:Down Syndrome / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011257:Pregnancy Proteins / Q000032:analysis*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis*; D011296:Prenatal Diagnosis
D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins