title: Hemadsorption focus assay for growth of influenza and parainfluenza viruses in human dermal fibroblasts.
abstract: An assay for virus-induced hemadsorption foci in cultures of human dermal fibroblasts is described. The assay allows determination of activity of species-specific as well as nonspecific antiviral agents or biological factors, such as interferons. The assay may be used for abortive (e.g., influenza virus) and productive (e.g., parainfluenza virus) infections of human fibroblasts.
authors.forename: D M
authors.initials: DM
authors.lastname: Bell
authors.forename: N J
authors.initials: NJ
authors.lastname: Roberts
authors.forename: H P
authors.initials: HP
authors.lastname: Madore
authors.forename: C B
authors.initials: CB
authors.lastname: Hall
authors.forename: R L
authors.initials: RL
authors.lastname: Simons
mesh_terms: D005347:Fibroblasts / Q000382:microbiology*; D006382:Hemadsorption; D006389:Hemagglutinins, Viral / Q000032:analysis; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D009975:Orthomyxoviridae / Q000254:growth & development*; D018108:Respirovirus / Q000254:growth & development*; D012867:Skin / Q000382:microbiology; D014776:Virus Cultivation
chemical_list: D006389:Hemagglutinins, Viral; D007370:Interferon Type I