Structural requirements for cannabinoid-induced antinociceptive activity in mice.
The antinociceptive activity of delta 9-THC was found to be 45 times greater after i.v. (ED50 = 1.0 mg/kg) than after s.c. administration while its ability to depress spontaneous activity was increased only 8 fold. Route of administration had less of an impact on the antinociceptive potency of hydroxylated metabolites and analogs of delta 9-THC. The structural requirements for antinociception and depression of spontaneous activity were found to be similar. Both routes of administration and structural alterations dramatically changed the antinociceptive potency of delta 9-THC.
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D000818:Animals; D013759:Dronabinol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013997:Time Factors; D014018:Tissue Distribution
D013759:Dronabinol