Effect of homologous tumor DNA on the evolution of SV40-induced hamster sarcoma.
DNA extracted from SV40-induced hamster sarcoma (SV40--HS DNA) increased the survival length of animals carrying the homologous tumor and--in some cases--inhibited the development of the tumor. The efficacy of the preparation was directly proportional to the number of administrations; it did not necessarily depend on the amount of SV40--HS DNA per dose. SV40 DNA had no favourable effect on the evolution of the SV40-induced tumor, which suggests that viral DNA does not represent the active component of the SV40--HS DNA preparations. Some possible mechanisms of the effect of homologous tumor preparations are discussed.
Nastac
E
E
Stoian
M
M
Iosipenco
M
M
Suru
M
M
Hozoc
M
M
Repanovici
R
R
D000818:Animals; D006224:Cricetinae; D004273:DNA, Neoplasm / Q000302:isolation & purification / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000401:mortality; D013539:Simian virus 40; D013997:Time Factors; D014412:Tumor Virus Infections / Q000188:drug therapy* / Q000401:mortality
D004273:DNA, Neoplasm