Studies on experimentally induced hyperphenylalaninemia.
The administration of several compounds that can increase plasma phenylalanine levels and/or inhibit phenylalanine hydroxylase in rats was studied in order to determine their usefulness in inducing a phenylketonuria-like state. The results of this investigation revealed that 4.5 microns/10 g p-chlorophenylalanine is more effective than L-phenylalanine, alpha-methylphenylalanine, trimethoprim, Bactrim and Septra, since the former compound produced both adequate hyperphenylalaninemia and marked inhibition of hepatic phenylalanine hydroxylase activity. In addition, a 24-h study provided important insights into the changing diurnal patterns of specified biochemical parameters.
Pueschel
S M
SM
Department of Pediatrics, Rhode Island Hospital, Brown University Program in Medicine, Providence 02903.
Boylan
J
J
Ellenbogen
R
R
D000818:Animals; D004195:Disease Models, Animal; D004338:Drug Combinations / Q000008:administration & dosage; D005260:Female; D010134:Fenclonine / Q000008:administration & dosage; D010649:Phenylalanine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood*; D010651:Phenylalanine Hydroxylase / Q000037:antagonists & inhibitors*; D010661:Phenylketonurias / Q000139:chemically induced* / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013420:Sulfamethoxazole / Q000008:administration & dosage; D014295:Trimethoprim / Q000008:administration & dosage; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D004338:Drug Combinations; C034515:phenylalanine methyl ester; D010649:Phenylalanine; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D010651:Phenylalanine Hydroxylase; D013420:Sulfamethoxazole; D010134:Fenclonine