Expression of the pX gene of HTLV-I: general splicing mechanism in the HTLV family.
Human T-cell leukemia virus type I (HTLV-I) is an etiological agent of adult T-cell leukemia. A viral gene pX encodes for p40X and it has been proposed that this protein trans-activates the viral long terminal repeat and possibly some cellular genes; this activation may be associated with T-cell transformation. The mechanism of pX gene expression and the primary structure of p40X are now reported. Two-step splicing generates the 2.1-kilobase pX mRNA; the initiator methionine for env becomes part of the pX protein. These splicing signals are conserved among all members of the HTLV family except for the acquired immune deficiency syndrome-associated viruses.
Seiki
M
M
Hikikoshi
A
A
Taniguchi
T
T
Yoshida
M
M
D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000032:analysis; D004262:DNA Restriction Enzymes / Q000378:metabolism; D004279:DNA, Viral / Q000032:analysis; D017977:Deltaretrovirus / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D009690:Nucleic Acid Conformation; D012326:RNA Splicing; D012367:RNA, Viral / Q000032:analysis; D051381:Rats
D004279:DNA, Viral; D012367:RNA, Viral; D004247:DNA; D004262:DNA Restriction Enzymes