title: The granulocyte-macrophage colony-stimulating factors.
abstract: The granulocyte-macrophage colony-stimulating factors are well-characterized specific glycoproteins that interact to control the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and monocyte-macrophages. Widely produced in the body, these regulators probably play an important role in resistance to infections. The proliferation of myeloid leukemia cells remains dependent on stimulation by colony-stimulating factors, although one of them also has the ability to suppress leukemic populations by inducing terminal differentiation.
authors.forename: D
authors.initials: D
authors.lastname: Metcalf
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D002455:Cell Division; D002470:Cell Survival; D003001:Cloning, Molecular; D003115:Colony-Stimulating Factors / Q000502:physiology*; D006098:Granulocytes / Q000502:physiology*; D006410:Hematopoiesis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000503:physiopathology; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D008970:Molecular Weight; D011956:Receptors, Cell Surface / Q000502:physiology; D016184:Receptors, Colony-Stimulating Factor; D013045:Species Specificity
chemical_list: D003115:Colony-Stimulating Factors; D011956:Receptors, Cell Surface; D016184:Receptors, Colony-Stimulating Factor