title: Studies of the putative transforming protein of the type I human T-cell leukemia virus.
abstract: The putative transforming protein of the type I human T-cell leukemia virus (HTLV-1) is a 40-kilodalton protein encoded by the X region and is termed p40XI. On the basis of both subcellular fractionation techniques and immunocytochemical analysis, it is now shown that p40XI is a nuclear protein with a relatively short half-life (120 minutes). It is synthesized de novo in considerable quantities in a human T-cell line infected with and transformed by the virus in vitro, and it is not packaged in detectable amounts in the extracellular virus.
authors.forename: D J
authors.initials: DJ
authors.lastname: Slamon
authors.forename: M F
authors.initials: MF
authors.lastname: Press
authors.forename: L M
authors.initials: LM
authors.lastname: Souza
authors.forename: D C
authors.initials: DC
authors.lastname: Murdock
authors.forename: M J
authors.initials: MJ
authors.lastname: Cline
authors.forename: D W
authors.initials: DW
authors.lastname: Golde
authors.forename: J C
authors.initials: JC
authors.lastname: Gasson
authors.forename: I S
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor / Q000276:immunology / Q000378:metabolism*; D002458:Cell Fractionation; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism; D002472:Cell Transformation, Viral; D017977:Deltaretrovirus / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007106:Immune Sera; D011233:Precipitin Tests; D014764:Viral Proteins / Q000276:immunology / Q000378:metabolism*
chemical_list: D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor; D007106:Immune Sera; D014764:Viral Proteins