title: Parabiosis between avian embryos resistant and susceptible to Rous sarcoma virus.
abstract: Parabiosis of chicken embryos was used to determine if resistance or susceptibility to Rous sarcoma virus (RSV) tumors could be transferred between RSV-resistant (R) and RSV-susceptible (S) embryos. Eggs from RSV-R and RSV-S lines were parabiosed at 12 days of incubation. One week after hatching the chicks were inoculated in the wing web with RSV. Birds were examined for tumor lesions through 9 weeks of age. Lesion scores of the nonparabiosed RSV-S line were significantly higher than nonparabiosed RSV-R lines. Lesion scores of RSV-R chicks that had been parabiosed to RSV-S chicks were higher than nonparabiosed RSV-R chicks. Lesion scores of RSV-S chicks parabiosed to RSV-R chicks were not different from nonparabiosed RSV-S chicks. These results suggest that the resistance to RSV was not transferred between parabionts but that there was significant transfer of susceptibility from the RSV-S embryos to the RSV-R embryos.
authors.forename: C T
authors.initials: CT
authors.lastname: Broussard
authors.forename: K W
authors.initials: KW
authors.lastname: Washburn
authors.forename: N R
authors.initials: NR
authors.lastname: Gyles
mesh_terms: D000818:Animals; D001358:Avian Sarcoma Viruses / Q000276:immunology*; D002642:Chick Embryo / Q000276:immunology*; D002645:Chickens / Q000235:genetics / Q000276:immunology*; D004198:Disease Susceptibility; D010227:Parabiosis; D001357:Sarcoma, Avian / Q000276:immunology*