Lack of preventive effect of 6-hydroxy-dopamine on a decrease of beta-adrenergic receptors induced by repeated stress in the heart of rats.
Immobilization stress (2.5 h daily) repeated daily for 7 days resulted in a significant decrease in the number of beta-adrenergic receptors in heart compared to control values. Administration of 6-hydroxy-dopamine failed to prevent the stress-induced reduction in the number of beta-adrenergic receptors in the heart of rats as compared to intact stressed rats. These results support the concept that beta-adrenergic receptors in the heart of rats are primarily under the control of the noradrenergic nervous system.
Torda
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Kopin
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D000818:Animals; D006321:Heart / Q000187:drug effects; D006892:Hydroxydopamines / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000378:metabolism*
D006892:Hydroxydopamines; D011943:Receptors, Adrenergic, beta; D016627:Oxidopamine