Aspects of cytokine induced modulation of immunity and inflammation with emphasis on interleukin 1.
Interleukin 1 (IL 1) contributes to both acute and chronic inflammatory processes. Purified IL 1 by itself is only one of the signals that induces local inflammation. The contribution of IL 1 to local inflammatory reactions is influenced by exogenous stimuli, antagonists such as steroid hormones and TGF beta (tissue growth factor beta) and agonists such as TNF (tissue necrosis factor). IL 1 production is depressed by glucocorticoids, but glucocorticoids induce expression of receptors for IL 1 on selected cell types including B lymphocytes and fibroblasts. Thus, complex interactions between hormones and cytokines modulate immunological and inflammatory responses.
Oppenheim
J J
JJ
National Cancer Institute, Biological Response Modifiers Program, Frederick, MD.
Lew
W
W
Akahoshi
T
T
Matsushima
K
K
Neta
R
R
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D005938:Glucocorticoids / Q000276:immunology; D006801:Humans; D007109:Immunity; D007249:Inflammation / Q000209:etiology* / Q000276:immunology; D007375:Interleukin-1 / Q000096:biosynthesis / Q000276:immunology / Q000502:physiology*; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000187:drug effects; D017472:Receptors, Interleukin-1; D013256:Steroids / Q000494:pharmacology
D005938:Glucocorticoids; D007375:Interleukin-1; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1; D013256:Steroids