Mls and the helper T-cell repertoire. I. Mls as a regulator of T-helper cell activation.
We provide evidence that the Mls reaction involves a broad cross-section of the helper cell population. In addition to those cells reacting overtly to Mls stimulatory spleen cells, there is a second large population of helper cells that are affected by an Mls difference. This latent Mls effect is manifested by either synergy or antagonism in mitogen-mediated, Ia-dependent T-cell activation, depending on Mlsa or Mlsb phenotypes of stimulator cells, respectively. Our data can be explained by attributing to Mls alleles the function of differential regulation of autoreactivity of T cells. The results show that the concept of the Mls exerting a negative signal deserves serious consideration.
Hämmerling
U
U
Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Toulon
M
M
Palfree
R G
RG
Hoffmann
M K
MK
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology*; D000949:Histocompatibility Antigens Class II; D008213:Lymphocyte Activation; D051379:Mice; D016747:Minor Lymphocyte Stimulatory Antigens; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000954:Antigens, Surface; D000949:Histocompatibility Antigens Class II; D016747:Minor Lymphocyte Stimulatory Antigens