title: Studies on a novel cytocidal antibiotic, trienomycin A. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics.
abstract: A new antibiotic, trienomycin A, has been isolated from the culture broth of Streptomyces sp. No. 83-16. The physico-chemical characteristics of the antibiotic suggested that it belongs to the group of ansamycin antibiotics with a triene moiety in the molecule. The molecular formula of trienomycin A is C36H50N2O7 (MW 622). The antibiotic possesses potent cytocidal activity against HeLa S3 and PLC hepatoma cells at concentrations of 0.1 and 0.01 micrograms/ml (IC50 value) respectively. However, trienomycin A showed no antimicrobial activity against the bacteria, fungi and yeasts examined with the exception of weak activity versus Piricularia oryzae at a concentration of 1,000 micrograms/ml.
authors.forename: I
authors.initials: I
authors.lastname: Umezawa
authors.forename: S
authors.initials: S
authors.lastname: Funayama
authors.forename: K
authors.initials: K
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Iwasaki
authors.forename: J
authors.initials: J
authors.lastname: Satoh
authors.forename: K
authors.initials: K
authors.lastname: Masuda
authors.forename: K
authors.initials: K
authors.lastname: Komiyama
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D006367:HeLa Cells; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
chemical_list: D000903:Antibiotics, Antineoplastic; C045958:trienomycin A; D000409:Alanine