title: [Disorders of plasma trace elements in diabetes. Relation to blood glucose equilibrium].
abstract: The influence of glycaemic control and diabetes characteristics on plasma concentrations of magnesium, zinc, copper, selenium, rubidium and bromine has been evaluated in 44 diabetics (30 insulin-dependent, 14 non insulin-dependent), and the results obtained were compared to those of 309 control subjects of the same mean age. Diabetics had reduced plasma magnesium concentrations (P less than 0.01) but normal erythrocyte magnesium levels. Plasma zinc and selenium concentrations were reduced, whereas those of copper were increased and those of bromine and rubidium were normal. Correlation between glycaemic control, evaluated by measurement of glycosylated haemoglobin levels, and each of the parameters studied was only demonstrated with magnesium in insulin-dependent diabetics (r = -0.561; P less than 0.02). No correlation was found with the other clinical or anthropometric characteristics of the diabetic patients studied. Diabetes seems to be associated with numerous abnormalities of plasma trace elements and magnesium, but the mechanism of these abnormalities has not yet been elucidated. A decrease in zinc and selenium concentrations and an increase in copper concentrations might be additional factors of atherogenicity.
authors.affiliation: Service de Médecine interne, Hôpital de Hautepierre, CHU, Strasbourg.
authors.forename: J L
authors.initials: JL
authors.lastname: Schlienger
authors.forename: F
authors.initials: F
authors.lastname: Grunenberger
authors.forename: E A
authors.initials: EA
authors.lastname: Maier
authors.forename: C
authors.initials: C
authors.lastname: Simon
authors.forename: G
authors.initials: G
authors.lastname: Chabrier
authors.forename: M J
authors.initials: MJ
authors.lastname: Leroy
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D001966:Bromine / Q000097:blood; D003300:Copper / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood; D008297:Male; D008875:Middle Aged; D012413:Rubidium / Q000097:blood; D012643:Selenium / Q000097:blood; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000097:blood
chemical_list: D001786:Blood Glucose; D014131:Trace Elements; D003300:Copper; D012643:Selenium; D008274:Magnesium; D015032:Zinc; D012413:Rubidium; D001966:Bromine
vernacular_title: Perturbation des oligoéléments plasmatiques dans le diabète. Relation avec l'équilibre glycémique.