[Tetrodotoxin competition with muscimol for the gamma-aminobutyric acid receptor].
It has been shown that tetrodotoxin inhibits GABA-receptor binding of muscimol with solubilized membranes of the rat brain in a competitive manner, with the inhibition constant amounting to about 3 nM. Muscimol has been also demonstrated to competitively inhibit 3H-tetrodotoxin binding with the same drug.
Kuznetsov
V I
VI
Tonkikh
A K
AK
Karanova
M V
MV
Sadykov
A A
AA
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D009118:Muscimol / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010080:Oxazoles / Q000378:metabolism*; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D012995:Solubility; D013779:Tetrodotoxin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D014316:Tritium; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D010080:Oxazoles; D011963:Receptors, GABA-A; D014316:Tritium; D009118:Muscimol; D013779:Tetrodotoxin; D005680:gamma-Aminobutyric Acid
Konkurentsiia tetrodotoksina s mustsimolom za retseptor gamma-aminomaslianoĭ kisloty.