title: Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III.
abstract: Antibodies from the serum of patients with the acquired immune deficiency syndrome (AIDS) or with the AIDS-related complex and from the serum of seropositive healthy homosexuals, recognize two major glycoproteins in cells infected with human T-cell lymphotropic virus type III (HTLV III). These glycoproteins, gp160 and gp120, are encoded by the 2.5-kilobase open reading frame located in the 3' end of the HTLV-III genome, as determined by amino terminus sequence analysis of the radiolabeled forms of these proteins. It is hypothesized that gp160 and gp120 represent the major species of virus-encoded envelope gene products for HTLV-III.
authors.forename: J S
authors.initials: JS
authors.lastname: Allan
authors.forename: J E
authors.initials: JE
authors.lastname: Coligan
authors.forename: F
authors.initials: F
authors.lastname: Barin
authors.forename: M F
authors.initials: MF
authors.lastname: McLane
authors.forename: J G
authors.initials: JG
authors.lastname: Sodroski
authors.forename: C A
authors.initials: CA
authors.lastname: Rosen
authors.forename: W A
authors.initials: WA
authors.lastname: Haseltine
authors.forename: T H
authors.initials: TH
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Essex
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000595:Amino Acid Sequence; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology*; D001483:Base Sequence; D017977:Deltaretrovirus / Q000276:immunology*; D005814:Genes, Viral; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology; D006801:Humans; D008970:Molecular Weight; D014415:Tunicamycin / Q000494:pharmacology; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D006023:Glycoproteins; D014759:Viral Envelope Proteins; D014415:Tunicamycin