Antibodies to human T cell leukemia virus are absent in patients with systemic lupus erythematosus.
It has been anticipated that type C oncornaviruses, which participate in the pathogenesis of murine systemic lupus erythematosus (SLE), would be found to have a role in the development of SLE in humans. In studies of tissues from SLE patients, type C-related proteins have been identified. Using information obtained on the recent isolation of the human T cell leukemia virus (HTLV), together with that from studies of murine SLE, we attempted to clarify the role of antibodies to HTLV in the pathogenesis of human SLE. Using a solid-phase enzyme-linked immunosorbent assay and sodium dodecyl sulfate-polyacrylamide gel electrophoretic techniques, we were unable to find evidence of the participation of antibodies to HTLV proteins in the development of human SLE.
Koike
T
T
Kagami
M
M
Takabayashi
K
K
Maruyama
N
N
Tomioka
H
H
Yoshida
S
S
D000914:Antibodies, Viral / Q000276:immunology*; D017977:Deltaretrovirus / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D012967:Sodium Dodecyl Sulfate
D000914:Antibodies, Viral; D012967:Sodium Dodecyl Sulfate