title: Mechanisms by which stressful stimuli activate the pituitary-adrenal system.
abstract: Stress-induced activation of the pituitary-adrenal system appears to be mediated predominantly by hypothalamic neurons containing ovine corticotropin-releasing factor (oCRF) and vasopressin in the region of the paraventricular nucleus (PVN). Other mediators such as catecholamines, serotonin, angiotensin, and "tissue CRF" may also play a role under certain conditions. Several weeks after ablation of the PVN the response to stress is largely restored while the plasma adrenocorticotropin rise normally elicited by adrenalectomy is still strongly inhibited and immunoreactive oCRF is depleted from the stalk-median eminence region.
authors.forename: G B
authors.initials: GB
authors.lastname: Makara
mesh_terms: D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D004837:Epinephrine / Q000502:physiology; D051379:Mice; D009638:Norepinephrine / Q000502:physiology; D010121:Oxytocin / Q000502:physiology; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000502:physiology*; D051381:Rats; D012701:Serotonin / Q000502:physiology; D013312:Stress, Physiological / Q000503:physiopathology*; D014667:Vasopressins / Q000502:physiology
chemical_list: D014667:Vasopressins; D000804:Angiotensin II; D012701:Serotonin; D010121:Oxytocin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D009638:Norepinephrine; D004837:Epinephrine