ACTH4-10 produces a transient decrease in septal hyperemotionality.
The administration of doses of ACTH4-10 that have been shown to be effective in producing enhanced peripheral nerve regeneration did not produce the enhanced rate of decline in hyperemotionality produced by administration of the ACTH4-9 variant Org 2766. Long-term changes in septal reactions in training situations were likewise not affected by ACTH4-10. These results indicate that, despite similar peripheral nerve growth effects, these two ACTH-related agents (ACTH4-10 and Org 2766) produce quite different long- and short-term effects on rats with septal area damage.
Isaacson
R L
RL
Poplawsky
A
A
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D004644:Emotions / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000502:physiology*
D010446:Peptide Fragments; C013765:Org 2766; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10)