Neonatal 6-hydroxydopamine lesion of spinal norepinephrine terminals fails to affect the ontogeny of swimming behavior.
Newborn rats were injected either systemically or intraspinally with 6-hydroxydopamine. Both treatments drastically reduced spinal norepinephrine (NE), while the former also reduced forebrain NE. Spinal NE loss did not affect the ontogeny or the adult expression of swimming, a sensitive test of complex patterned locomotion. Spinal NE is not essential to either the ontogeny of complex motor behavior or to the generation of such behavior in adult rats.
Ryan
C
C
Pappas
B A
BA
D000818:Animals; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000502:physiology*; D013550:Swimming; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission
D006892:Hydroxydopamines; D016627:Oxidopamine; D009638:Norepinephrine