Human testicular angiotensin-converting enzyme is a mixture of two molecular weight forms. Only one is similar to the seminal plasma enzyme.
Two molecular weight (Mr) forms of angiotensin-converting enzyme are present in human testis. Both the high Mr 140,000 form and the low Mr 90,000 form are catalytically similar but immunologically distinct. After isoelectric focusing, the profile of sialylated Mr 140,000 isozymes resembled that of seminal plasma converting enzyme, whereas the nonsialylated Mr 90,000 isozymes were distinct. These data suggest that the Mr 140,000 testicular converting enzyme may be a source of converting enzyme in seminal plasma.
Lanzillo
J J
JJ
Dasarathy
Y
Y
Stevens
J
J
Bardin
C W
CW
Fanburg
B L
BL
D006801:Humans; D007124:Immunoenzyme Techniques; D007527:Isoenzymes / Q000032:analysis*; D008297:Male; D008970:Molecular Weight; D007703:Peptidyl-Dipeptidase A / Q000032:analysis*; D012661:Semen / Q000201:enzymology*; D013737:Testis / Q000201:enzymology*
D007527:Isoenzymes; D007703:Peptidyl-Dipeptidase A