2',3'-Cyclic nucleotide 3'-phosphohydrolase in acrylamide-induced optic neuropathy in rabbit.
The in vivo effects of acrylamide on the nerve tissues of the rabbit optic pathway were examined. The optic nerve of acrylamide-treated rabbits showed inflammatory changes and degeneration. The decrease of myelin was observed with myelin stain. The activity of 2',3'-cyclic nucleotide 3'-phosphohydrolase (EC.3.1.4.37) which is firmly bound to myelin was markedly diminished by acrylamide intoxication.
Ohki
K
K
Machi
N
N
Matsushima
S
S
Mizuno
A
A
D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism*; D000178:Acrylamides; D000818:Animals; D003711:Demyelinating Diseases / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology; D009186:Myelin Sheath / Q000473:pathology; D009410:Nerve Degeneration; D009900:Optic Nerve / Q000473:pathology; D009901:Optic Nerve Diseases / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology; D010727:Phosphoric Diester Hydrolases; D011817:Rabbits; D012160:Retina / Q000473:pathology
D000178:Acrylamides; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D010727:Phosphoric Diester Hydrolases; D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase