Studies on a novel cytocidal antibiotic, trienomycin A. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics.
A new antibiotic, trienomycin A, has been isolated from the culture broth of Streptomyces sp. No. 83-16. The physico-chemical characteristics of the antibiotic suggested that it belongs to the group of ansamycin antibiotics with a triene moiety in the molecule. The molecular formula of trienomycin A is C36H50N2O7 (MW 622). The antibiotic possesses potent cytocidal activity against HeLa S3 and PLC hepatoma cells at concentrations of 0.1 and 0.01 micrograms/ml (IC50 value) respectively. However, trienomycin A showed no antimicrobial activity against the bacteria, fungi and yeasts examined with the exception of weak activity versus Piricularia oryzae at a concentration of 1,000 micrograms/ml.
Umezawa
I
I
Funayama
S
S
Okada
K
K
Iwasaki
K
K
Satoh
J
J
Masuda
K
K
Komiyama
K
K
D000409:Alanine / Q000031:analogs & derivatives; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D006367:HeLa Cells; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; C045958:trienomycin A; D000409:Alanine