title: High-dose cyclophosphamide with autologous bone marrow rescue after conventional chemotherapy in the treatment of small cell lung carcinoma.
abstract: Within an original consecutive series of 94 patients, 36 eligible patients with small cell lung carcinoma were treated with high-dose cyclophosphamide 7 g/m2 after conventional chemotherapy with VP16, adriamycin, and vincristine. The first 17 also underwent autologous bone marrow rescue. Treatment was well tolerated apart from one treatment-related death. Measurable tumour was still present in 15 patients before high-dose cyclophosphamide, and although 12 (80%) of these achieved further tumour response, these responses were all short-lived, with a median duration of 9 weeks. In 14 limited-disease patients already in complete remission before high-dose therapy the initial result was better, but 11 (79%) have now relapsed following overall median response duration of 10 months. High-dose cyclophosphamide after conventional chemotherapy is feasible and achieves a high response rate, but it does not appear to be associated with significant survival benefit either overall or in patient subgroup.
authors.forename: I E
authors.initials: IE
authors.lastname: Smith
authors.forename: B D
authors.initials: BD
authors.lastname: Evans
authors.forename: S J
authors.initials: SJ
authors.lastname: Harland
authors.forename: B A
authors.initials: BA
authors.lastname: Robinson
authors.forename: J R
authors.initials: JR
authors.lastname: Yarnold
authors.forename: J G
authors.initials: JG
authors.lastname: Glees
authors.forename: H T
authors.initials: HT
authors.lastname: Ford
mesh_terms: D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000401:mortality; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D014182:Transplantation, Autologous
chemical_list: D003520:Cyclophosphamide