title: Epinephrine is unessential for stimulation of liver glycogenolysis during exercise.
abstract: To determine the role of adrenal medullary hormones in controlling the rate of liver glycogenolysis during exercise, adrenodemedullated (ADM) and sham-operated (SO) rats were run on a rodent treadmill at 21 m/min up a 15% grade for 0, 30, or 60 min. Rats were anesthetized by intravenous injection of pentobarbital sodium, and liver, muscle, and blood were collected and frozen. Liver glycogen decreased at similar rates in ADM and SO rats. Hepatic adenosine 3',5'-cyclic monophosphate (cAMP), plasma glucagon, and plasma free fatty acids increased to the same extent in both ADM and SO rats. The adrenodemedullation caused a reduction in glycogenolysis in the fast-twitch white region of the quadriceps, soleus, and lateral gastrocnemius during exercise. The normal exercise-induced increase in blood glucose and lactate and the decline in plasma insulin were not observed in the demedullated rats. During submaximal exercise the principal targets for epinephrine released from the adrenal medulla appear to be pancreatic beta-cells and skeletal muscle and not the liver.
authors.forename: K I
authors.initials: KI
authors.lastname: Carlson
authors.forename: J C
authors.initials: JC
authors.lastname: Marker
authors.forename: D A
authors.initials: DA
authors.lastname: Arnall
authors.forename: M L
authors.initials: ML
authors.lastname: Terry
authors.forename: H T
authors.initials: HT
authors.lastname: Yang
authors.forename: L G
authors.initials: LG
authors.lastname: Lindsay
authors.forename: M E
authors.initials: ME
authors.lastname: Bracken
authors.forename: W W
authors.initials: WW
authors.lastname: Winder
mesh_terms: D000313:Adrenal Medulla / Q000502:physiology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D004837:Epinephrine / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005934:Glucagon / Q000097:blood; D006003:Glycogen / Q000378:metabolism; D007328:Insulin / Q000097:blood; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008099:Liver / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000378:metabolism; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007773:Lactates; D008112:Liver Glycogen; D019344:Lactic Acid; D006003:Glycogen; D005934:Glucagon; D000242:Cyclic AMP; D004837:Epinephrine