[Prevention of disorders of cardiac contractility with nicotinamide in adriblastin -related damage].
Pretreatment with 20 mg/kg nicotinamide 3 days prior to a single intraperitoneal 6 mg/kg adriblastin injection, followed by repeated injections every second days for 1 week, prevented cardiac contractility disorders in adriblastin-treated rats, while their cardiac contractility was less prone to hypoxic depression and recovered better at subsequent reoxygenation.
Nurmukhambetov
A N
AN
Riabtseva
T A
TA
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000188:drug therapy*; D004317:Doxorubicin / Q000009:adverse effects*; D006333:Heart Failure / Q000209:etiology / Q000517:prevention & control*; D000860:Hypoxia / Q000139:chemically induced / Q000188:drug therapy*; D009200:Myocardial Contraction / Q000187:drug effects*; D009536:Niacinamide / Q000627:therapeutic use*; D051381:Rats
D009536:Niacinamide; D004317:Doxorubicin
Preduprezhdenie narusheniĭ sokratitel'noĭ funktsii serdtsa pri adriblastinovom povrezhdenii s pomoshch'iu nikotinamida.