title: Effect of a slow-release formula of trimoprostil on intragastric acidity in healthy volunteers.
abstract: We investigated the effect of a slow-release formula of trimoprostil, a prostaglandin E2 analogue, at a dose of 3 mg b.d. on circadian intragastric acidity in nine healthy volunteers using ambulatory pH-metry in a placebo-controlled study. The effect of trimoprostil was long lasting (8 hours during the night). However, it lowered gastric pH on average only by 0.4 pH units. In four of the six women severe side-effects occurred in the form of abdominal cramping, metrorrhagia, and/or diarrhoea. These disadvantages may limit the clinical use of this drug.
authors.affiliation: Stadtspital Triemli, Zurich, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Emde
authors.forename: T
authors.initials: T
authors.lastname: Cilluffo
authors.forename: P
authors.initials: P
authors.lastname: Bauerfeind
authors.forename: C J
authors.initials: CJ
authors.lastname: Fimmel
authors.forename: A L
authors.initials: AL
authors.lastname: Blum
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D015232:Dinoprostone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D006801:Humans; D008297:Male
chemical_list: D000897:Anti-Ulcer Agents; D003692:Delayed-Action Preparations; C038879:trimoprostil; D015232:Dinoprostone