title: Cystatin, a protein inhibitor of cysteine proteases alters viral protein cleavages in infected human cells.
abstract: Chicken cystatin is a previously described small protein which has the property of inhibiting cysteine active site proteases. The protein, when added to cultured human cells, alters the intracellular proteolytic processing of poliovirus proteins, and causes a reduction in virus yield. It is suggested that the cystatin is able to penetrate to the cellular cytoplasm and inhibit the action of the poliovirus protease.
authors.forename: B D
authors.initials: BD
authors.lastname: Korant
authors.forename: J
authors.initials: J
authors.lastname: Brzin
authors.forename: V
authors.initials: V
authors.lastname: Turk
mesh_terms: D000818:Animals; D002460:Cell Line; D002645:Chickens; D015891:Cystatins; D006367:HeLa Cells / Q000382:microbiology; D006801:Humans; D017955:Poliovirus / Q000502:physiology*; D011480:Protease Inhibitors / Q000494:pharmacology; D011506:Proteins / Q000494:pharmacology*; D014764:Viral Proteins / Q000096:biosynthesis*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D015891:Cystatins; D011480:Protease Inhibitors; D011506:Proteins; D014764:Viral Proteins; C100158:cystatin, egg-white