[Effects of anti-tumor drugs and gastrointestinal hormones on the growth of pancreatic duct cell adenocarcinoma in homologous transplanted animal models].
The pancreatic duct cell adenocarcinoma induced by di-isopropanol nitrosamine in Syrian golden hamsters could be easily and repeatedly into the subcutaneous tissues or the pancreas of the homologous animals. We examined the anti-tumor effects of the administration of FT-207 and the coadministration of FT-207 and uracil on the pancreatic cancer transplanted into the subcutaneous tissues and the pancreas. The inhibitory effect on the tumor growth observed in the group treated with FT-207 and uracil was more striking than that in the group treated with only FT-207. Such enhanced anti-tumor effect observed in the coadministration group seemed to be due to the increased 5-FU concentration in the tumor tissues. Some gastrointestinal hormones (cholecystokinin, caerulein, secretin and tetragastrin) injected intraperitoneally promoted the growth of subcutaneously transplanted tumor. These gastrointestinal hormones except tetragastrin also increased the weight of the pancreas. In an analysis of RNA and DNA contents and RNA/DNA ratio in tumor tissues, the promotion of the tumor growth seemed to stem from hyperplasia and/or hypertrophy of the cancer cells. Therefore, it is suggested that some gastrointestinal hormones have trophic actions on the pancreatic duct cell adenocarcinoma as well as normal pancreas.
Ohyama
K
K
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002273:Carcinogens; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D006224:Cricetinae; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D008297:Male; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D009602:Nitrosamines; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D005641:Tegafur / Q000627:therapeutic use; D014498:Uracil / Q000627:therapeutic use
D000970:Antineoplastic Agents; D002273:Carcinogens; D005768:Gastrointestinal Hormones; D009602:Nitrosamines; D005641:Tegafur; C012457:diisopropanolnitrosamine; D014498:Uracil