title: Role of the galt contrasuppressor T cell circuit in isotype-specific immunoregulation.
abstract: GALT contains Tcs cells which protect IgA responses under conditions of oral tolerance. Oral immunization of erythrocyte antigen induces antigen-specific Tcs cells in Peyer's patches which predominantly support IgA responses with minor IgM and IgG responses upon adoptive transfer to tolerized mice. On the other hand, systemically-primed mice possess Tcs cells which convert oral tolerance to only IgM and IgG responses. In general, effector Tcs cells which abrogate antigen-specific oral tolerance are Lyt-1+, Lyt-2-, L3T4-, I-J+ and V. villosa-adherent. Interestingly, these Tcs cells express T3 molecules which suggest the expression of a TCR which may account for their antigen specificity.
authors.affiliation: Department of Microbiology, University of Alabama, Birmingham 35294.
authors.forename: K
authors.initials: K
authors.lastname: Fujihashi
authors.forename: H
authors.initials: H
authors.lastname: Kiyono
authors.forename: K W
authors.initials: KW
authors.lastname: Beagley
authors.forename: J H
authors.initials: JH
authors.lastname: Eldridge
authors.forename: J R
authors.initials: JR
authors.lastname: McGhee
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000008:administration & dosage; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D000950:Antigens, Ly / Q000032:analysis; D007108:Immune Tolerance; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis*; D007422:Intestines / Q000166:cytology / Q000276:immunology*; D051379:Mice; D009092:Mucous Membrane / Q000276:immunology; D010581:Peyer's Patches / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D000941:Antigens; D000945:Antigens, Differentiation, T-Lymphocyte; D000950:Antigens, Ly; D007070:Immunoglobulin A; D007132:Immunoglobulin Isotypes