Cryolumpectomy for breast cancer: an experimental study.
The effects of cryosurgical procedures and surgical excision in preventing the local recurrence of mammary adenocarcinoma were studied in BALB/cfC3H mice carrying syngeneic, virus-induced mammary adenocarcinomas transplanted into the fourth mammary fat pad. In this report we present evidence demonstrating that cryosurgical procedures involving multiple freeze-thaw cycles followed by tumor excision markedly reduce the local recurrence rate of mouse mammary cancer. Surgical resection without cryotreatment resulted in an 80% local recurrence rate; in contrast, cryotreatment consisting of three freeze-thaw cycles before excision prevented local tumor recurrence in 70% of the animals. The use of cryotherapy and local excision (cryolumpectomy) in the treatment of human breast cancer is discussed.
Rand
R W
RW
Rand
R P
RP
Eggerding
F A
FA
Field
M
M
Denbesten
L
L
King
W
W
Camici
S
S
D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000368:Aged; D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000601:surgery; D003452:Cryosurgery; D005260:Female; D005615:Freezing; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000473:pathology / Q000601:surgery*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control