Effects of isradipine, a new calcium antagonist, versus hydrochlorothiazide on serum lipids and apolipoproteins in patients with systemic hypertension.
The effect of isradipine versus hydrochlorothiazide on the lipid profile of 44 hypertensive patients was investigated in a double-blind, randomized, 2-center trial. Lipid profiles included total cholesterol, serum triglycerides, high density lipoprotein (HDL) cholesterol, HDL subclasses, (HDL2 and HDL3), low density lipoprotein cholesterol, very low density lipoprotein cholesterol, apolipoprotein A-1 and apolipoprotein B. Isradipine had no effect on the lipid profile in short- (4 and 10 week) or long-term (52 week) studies. Hydrochlorothiazide increased serum triglycerides in 11 of 13 patients by a mean of 8% for the group (p less than 0.05) in long-term (52 week) studies, and total cholesterol by a mean of 9 and 16%, respectively (p less than 0.01) in 2 of 13 patients, with no difference in other lipid or lipoprotein parameters in short- or long-term studies.
Samuel
P
P
Long Island Jewish Medical Center, Manhasset, New York 11030.
Kirkendall
W
W
Schaefer
E J
EJ
Chin
B
B
Schoenfeld
B H
BH
Gonasun
L M
LM
Lieberman
S
S
D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000097:blood*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D017275:Isradipine; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011725:Pyridines / Q000627:therapeutic use*; D011897:Random Allocation; D013997:Time Factors
D001053:Apolipoproteins; D002121:Calcium Channel Blockers; D008055:Lipids; D011725:Pyridines; D006852:Hydrochlorothiazide; D017275:Isradipine