CD45R gives immunofluorescence and transduces signals on mouse T cells.
The expression of CD45R on mouse T cells has been studied. This antigen is expressed on the two higher molecular weight bands of CD45 (or T200) and in mouse it is currently used as a marker of B cells (B220). Here we confirm that CD45R is expressed on some mouse T cell clones. We show that a small but measurable proportion of mouse spleen and peripheral blood lymphocyte T cells gives positive immunofluorescence with B220. Also CD45R-specific antibodies increase the proliferation response to phytohemagglutinin up to 3-fold, thus confirming that CD45R molecules transduce a signal into mouse T cells.
Marvel
J
J
Imperial Cancer Research Fund, University College London, GB.
Mayer
A
A
D000818:Animals; D000943:Antigens, Differentiation / Q000502:physiology*; D005455:Fluorescent Antibody Technique; D006649:Histocompatibility Antigens / Q000502:physiology*; D017493:Leukocyte Common Antigens; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D010835:Phytohemagglutinins / Q000494:pharmacology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000943:Antigens, Differentiation; D006649:Histocompatibility Antigens; D010835:Phytohemagglutinins; D017493:Leukocyte Common Antigens