Effects of aniline on neuromuscular transmission.
Aniline hydrochloride increased the amplitude of the end-plate potentials of the frog sartorius muscle. Statistical analysis showed that the effects of aniline were purely presynaptic. The shape of the dose-release curve was similar to that of the 4-aminopyridine curve although the potency was weaker than that of 4-aminopyridine. The molecular configuration and the effect of aniline suggested that the site of action of aniline was the same as that of 4-aminopyridine.
Enomoto
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Maeno
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D015761:4-Aminopyridine; D000200:Action Potentials / Q000187:drug effects; D000631:Aminopyridines / Q000494:pharmacology; D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D011898:Ranidae; D013329:Structure-Activity Relationship; D009435:Synaptic Transmission / Q000187:drug effects*
D000631:Aminopyridines; D000814:Aniline Compounds; D015761:4-Aminopyridine; C023650:aniline; D002118:Calcium