Toxicity of trimetrexate on hemopoietic progenitor cells in normal mice.
Single increasing doses of methotrexate (MTX) and trimetrexate (TMQ) were administered to normal mice. Survival of hemopoietic progenitor cells assayed as CFU-S and GM-CFC was determined 24 hr after drug injection. The survival of each population in TMQ-treated animals was not statistically different from that observed in mice treated with MTX. No difference was observed in time-survival curves of hemopoietic progenitor cells comparing TMQ to MTX. TMQ toxicity at the hematological level thus seems comparable to that of MTX.
Bogliolo
G V
GV
Patologia Speciale Medica B, University of Genoa, Italy.
Lerza
R A
RA
Mencoboni
M P
MP
Saviane
A G
AG
Pannacciulli
I M
IM
D000818:Animals; D001854:Bone Marrow Cells; D003114:Colony-Forming Units Assay; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D008727:Methotrexate / Q000633:toxicity; D051379:Mice; D008811:Mice, Inbred DBA; D011799:Quinazolines / Q000633:toxicity*; D016597:Trimetrexate
D011799:Quinazolines; D016597:Trimetrexate; D008727:Methotrexate