title: Inhibitory effects of some organometallic complexes of rhodium(I) and iridium(I) on carrageenin paw edema in rats.
abstract: A group of 4 organometallic complexes of Rhodium (I) and 1 Iridium(I) was tested for the evaluation of their anti-inflammatory activity on carrageenin paw edema in rats. All the compounds used inhibited the development of paw edema by more than 50% at different dose-levels. The activity of the pyridinalmethylimine derivative [Rh(COD)PMI]+ Cl- had better results than that of [Rh(NBD)PMI]+ Cl- and even more than the dimeric complexes tested. The higher activity of [Ir(COD)Cl]2 as compared with [Rh(COD)Cl]2 suggests that it would be of interest to examine further Iridium(I) complexes, among which [Ir(COD)PMI]+ Cl- could be a good candidate.
authors.affiliation: Institute of Pharmacology, Faculty of Pharmacy, University of Trieste, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Sava
authors.forename: P
authors.initials: P
authors.lastname: Piccini
authors.forename: G
authors.initials: G
authors.lastname: Mestroni
authors.forename: G
authors.initials: G
authors.lastname: Zassinovich
authors.forename: A
authors.initials: A
authors.lastname: Bontempi
mesh_terms: D000818:Animals; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D007495:Iridium / Q000627:therapeutic use* / Q000633:toxicity; D008297:Male; D009942:Organometallic Compounds / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012413:Rubidium / Q000627:therapeutic use* / Q000633:toxicity
chemical_list: D009942:Organometallic Compounds; D007495:Iridium; D002351:Carrageenan; D012413:Rubidium