title: Effects of eel calcitonin on plasma beta-endorphin-like immunoreactivity levels in rats.
abstract: The effect of synthetic eel calcitonin (CT) on the level of plasma beta-endorphin-like immunoreactivity (beta-En-LI) and on its content in hypothalamus and anterior pituitary in vivo and on the release of beta-En-LI-from anterior pituitary in vitro was studied. The level of beta-En-LI was increased significantly in a dose-dependent manner after the injection of 1-100 U/kg CT, maximum level being found at 10 min after the injection. After the administration of 50 U/kg CT, the increase was still significant at 40 min. Such an increase was not found in hypophysectomized animals. The content of beta-En-LI in the hypothalamus and anterior pituitary did not change significantly after CT injection. In vitro, the release of beta-En-LI from anterior pituitary was enhanced significantly after CT. It may be concluded that CT acts on the pituitary to increase the release of beta-En-LI which results in increased plasma level.
authors.affiliation: Fourth Department of Internal Medicine, Aichi Medical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mitsuma
authors.forename: Y
authors.initials: Y
authors.lastname: Hirooka
authors.forename: A
authors.initials: A
authors.lastname: Nomura
authors.forename: H
authors.initials: H
authors.lastname: Okamoto
authors.forename: T
authors.initials: T
authors.lastname: Nogimori
mesh_terms: D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D007016:Hypophysectomy; D007031:Hypothalamus / Q000032:analysis; D066298:In Vitro Techniques; D008297:Male; D010903:Pituitary Gland, Anterior / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin / Q000097:blood*
chemical_list: D001615:beta-Endorphin; D002116:Calcitonin