Studies on recombination within the mouse H-2 complex: IV. Characterization of new recombinant haplotypes H-2t7, H-2t8, H-2as2, and H-2as3.
Four new intra-H-2 recombinants were characterized serologically and functionally. In two of these recombinants, B10.ASR1 and B10.ASR7, crossing over occurred between the A alpha and E alpha subregions, very probably in E beta since most intra-I region recombinants thus far investigated at the DNA level appear to involve recombination within the E beta gene. In the other two recombinants, B10.ASR2 and B10.ARS8, crossing over occurred between the S and D subregions. B10.ASR2 and B10.ASR8, crossing over occurred between the S and D subregions. B10.ASR7, which is serologically indistinguishable from B10.BASR1 and B10.S(8R), slightly stimulates and strongly responds to both of these strains in MLR. The probable location of the B10.S(8R) stimulatory product is E beta. The H-2 composition of B10.ASR1 is closest to that of B10.S(9R) and B10.HTT; therefore, precise definition of the cross-over point at the DNA level will be of particular interest.
Hauptfeld
M
M
Department of Genetics, Washington University, School of Medicine, St. Louis, MO 63310.
Hauptfeld
V
V
Zeff
R
R
Shreffler
D C
DC
D000818:Animals; D002874:Chromosome Mapping; D003434:Crossing Over, Genetic; D006183:H-2 Antigens / Q000235:genetics; D006239:Haplotypes; D006386:Hemagglutination Tests; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D007959:Lymphocyte Culture Test, Mixed; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D011205:Povidone; D011995:Recombination, Genetic; D016038:Skin Transplantation
D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II; D011205:Povidone