Interleukin 2 inhibits in vitro growth of human T cell lines carrying retrovirus.
Four human T cell lines, TL-Mor, TL-Su, TL-TerI, and TL-OmI, carrying human T cell leukemia virus (HTLV), were established previously. TL-Mor, TL-Su, and TL-TerI were derived from interleukin 2 (IL-2)-dependent parental cell lines cloned from peripheral blood leukocytes (PBL) of three healthy HTLV carriers, while TL-OmI was directly established from PBL of a patient with adult T cell leukemia. These four TL cell lines grow autonomously without IL-2. When they were cultured in the presence of IL-2, their growth was inhibited after a few days. This growth inhibition depended on the dose of IL-2, and the effective dose significantly promoted growth of their parental IL-2-dependent cell lines. The growth inhibition is demonstrated to be due to specific binding of IL-2 to receptors on the TL cells.
Sugamura
K
K
Nakai
S
S
Fujii
M
M
Hinuma
Y
Y
D002460:Cell Line; D002472:Cell Transformation, Viral; D017977:Deltaretrovirus; D004306:Dose-Response Relationship, Immunologic; D006131:Growth Inhibitors / Q000502:physiology*; D006801:Humans; D007376:Interleukin-2 / Q000502:physiology*; D008213:Lymphocyte Activation; D012192:Retroviridae Infections / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*
D006131:Growth Inhibitors; D007376:Interleukin-2