Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells.
Human interleukin 2 (IL-2) receptor cDNA derived from HUT 102B2 cells was stably expressed in murine L cells. These L cell transfectants (a) displayed surface receptors of the aberrant size of the IL-2 receptors on HUT 102B2 cells, (b) did not respond to exogenous IL-2 with augmented proliferation, and (c) expressed low affinity but not high affinity receptors for IL-2.
Greene
W C
WC
Robb
R J
RJ
Svetlik
P B
PB
Rusk
C M
CM
Depper
J M
JM
Leonard
W J
WJ
D000818:Animals; D004247:DNA / Q000235:genetics*; D005822:Genetic Vectors; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology*; D007739:L Cells / Q000276:immunology; D051379:Mice; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D015375:Receptors, Interleukin-2; D013539:Simian virus 40 / Q000235:genetics; D014162:Transfection
D007376:Interleukin-2; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D004247:DNA