Map location of homologous regions between Marek's disease virus and herpesvirus of turkey and the absence of detectable homology in the putative tumor-inducing gene.
The DNA region having homology between Marek's disease virus and herpesvirus of turkey was assigned to the restriction map of Marek's disease virus by Southern blot hybridization. Under moderate conditions at the level of 15% mismatching, homology was found to be distributed throughout the Marek's disease virus genome. The long inverted-repeat regions (TRL and IRL), which are considered to play a significant role in tumorigenicity, did not show any homology to herpesvirus of turkey DNA.
Fukuchi
K
K
Sudo
M
M
Tanaka
A
A
Nonoyama
M
M
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D004279:DNA, Viral / Q000032:analysis*; D005814:Genes, Viral; D006564:Herpesviridae / Q000235:genetics*; D008381:Herpesvirus 2, Gallid / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D014422:Turkeys / Q000382:microbiology
D004279:DNA, Viral