Failure of passively administered anti-Rh to prevent secondary Rh responses.
Rh-negative women, immunized to Rh by previous pregnancies, with only low concentrations of IgG anti-Rh(D) in their plasma were assigned at random to test and control groups (7 subjects in each group). Both groups were challenged with an intravenous injection of 0.28 ml of Rh-positive red cells; in addition, the test group received 500 micrograms anti-Rh intramuscularly. 2 weeks after the injections, all subjects showed an increase in plasma anti-Rh concentration; levels in test and control groups were similar. It is concluded that in Rh-immunized subjects with low levels of IgG anti-Rh a secondary response to Rh cannot be prevented by giving passively administered anti-Rh with the red cells.
de Silva
M
M
Contreras
M
M
Mollison
P L
PL
D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007117:Immunization, Secondary; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007136:Immunoglobulins / Q000276:immunology*; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D018029:Rho(D) Immune Globulin
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin