title: Cardiac effects of sodium stibogluconate.
abstract: Sodium stibogluconate although potentially cardiotoxic is the drug of choice for Kalaazar and cutaneous leishmaniasis due to Leishmania braziliensis. Increasing use of this drug in the British Army has necessitated a formal evaluation of its cardiac side-effects. Consequently a detailed study of the cardiac effects of sodium stibogluconate was undertaken in 22 male soldiers using for the first time modern non-invasive techniques. Intravenous sodium stibogluconate 600 mg daily for 10 days did not affect blood pressure, heart rate, left ventricular contractile function or rhythm. Electrocardiography showed a reversible reduction of T wave amplitude.
authors.forename: A
authors.initials: A
authors.lastname: Henderson
authors.forename: D
authors.initials: D
authors.lastname: Jolliffe
mesh_terms: D000293:Adolescent; D000328:Adult; D000967:Antimony Sodium Gluconate / Q000009:adverse effects*; D004452:Echocardiography; D004562:Electrocardiography; D005942:Gluconates / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007896:Leishmaniasis / Q000188:drug therapy; D008297:Male; D008991:Monitoring, Physiologic
chemical_list: D005942:Gluconates; D000967:Antimony Sodium Gluconate