PK 11195, an antagonist of peripheral benzodiazepine receptors, reduces ventricular arrhythmias during myocardial ischemia and reperfusion in the dog.
PK 11195, an antagonist of peripheral type benzodiazepine receptors, in doses from 5 to 25 mg/kg i.d. protected in a dose-dependent manner dogs against both early and delayed ventricular arrhythmias induced by 20 min ischemia and against ventricular fibrillation following reperfusion. Thus, peripheral-type benzodiazepine receptors might represent a novel target in the treatment of angina and cardiac ischemia.
Mestre
M
M
Bouetard
G
G
Uzan
A
A
Gueremy
C
C
Renault
C
C
Dubroeucq
M C
MC
Le Fur
G
G
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000150:complications / Q000503:physiopathology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D011963:Receptors, GABA-A / Q000187:drug effects*
D000889:Anti-Arrhythmia Agents; D007546:Isoquinolines; D011963:Receptors, GABA-A; C037850:PK 11195