Behavioral effects of alpha-benzyl-N-methylphenethylamine (ABNMP), a methamphetamine analog: inhibition by ketanserin and para-chlorophenylalanine (PCPA).
Acute administration of alpha-benzyl-N-methylphenethylamine (ABNMP) induces lateral heavings, straub tail, backward locomotion, and hindlimb abduction-which are all components of the serotonin (5-HT) syndrome. Ketanserin, a 5-HT-2 receptor antagonist and pretreatment with the 5-HT neurotoxin parachlorophenylalanine (PCPA) attenuated the manifestation of these behavioral abnormalities. These results suggest that ABNMP may cause an acute release of 5-HT similar to that elicited by para-chloroamphetamine.
Cadet
J L
JL
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032.
Clark
C R
CR
Fahn
S
S
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D010134:Fenclonine / Q000494:pharmacology*; D007650:Ketanserin / Q000494:pharmacology*; D008297:Male; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects
D008694:Methamphetamine; C006733:alpha-benzyl-N-methylphenethylamine; D007650:Ketanserin; D010134:Fenclonine