Motor responses of cyproterone acetate-treated rat vas deferens to electrical field stimulation, noradrenaline and barium chloride.
The effect of cyproterone acetate (CA) was studied on the autonomic transmission and smooth muscle function of the rat vas deferens. In the CA-treated vas deferens, the endogenously released noradrenaline (NA) in response to electrical field stimulation or exogenously administered NA produced rhythmic contractions (lacking a tonic component) which were abolished by prazosin - a preferential postjunctional alpha-adrenoceptor blocker. The biphasic nature of the nonadrenergic response elicited on electrical field stimulation in CA-treated rats remained unaltered. Like in controls, yohimbine potentiated this response thereby demonstrating the presence of functional presynaptic alpha-adrenoceptors (inhibitory in nature). The postjunctional alteration on the membrane function appears to be specific to adrenergic stimulation alone, since both tonic and phasic components were demonstrated in the responses resulting from nonadrenergic stimulation or those produced by barium chloride.
Raviprakash
V
V
Mishra
S K
SK
Panda
J N
JN
D000818:Animals; D001464:Barium / Q000494:pharmacology*; D017609:Barium Compounds; D002369:Castration; D002712:Chlorides; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects; D015016:Yohimbine / Q000494:pharmacology
D017609:Barium Compounds; D002712:Chlorides; D011942:Receptors, Adrenergic, alpha; C024986:barium chloride; D001464:Barium; D015016:Yohimbine; D017373:Cyproterone Acetate; D003534:Cyproterone; D009638:Norepinephrine; D011224:Prazosin