The influence of bromocriptine on the ultrastructure of the biceps femoris muscle in mice.
Bromocriptine and other dopaminergic agonists drugs are used in Parkinson's disease. In this paper we have studied the ultrastructure of striated muscle of mice after bromocriptine treatment. There was a tremendous increase in the number and size of mitochondria, as well as a very notable increase in the cristae. Some ultrastructure changes were also noted at the neuromuscular junctions. An explanation has been attempted in the light of other investigations concerning the relationship of microtubules and bromocriptine on the one hand, and microtubules and mitochondria on the other.
Stravoravdi
P
P
Theagenion Cancer Institute, Symeonidis Research Center, Thessaloniki, Greece.
Polyzonis
M
M
Demetriou
T
T
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D008870:Microtubules / Q000187:drug effects / Q000648:ultrastructure; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000648:ultrastructure; D009132:Muscles / Q000187:drug effects / Q000648:ultrastructure*; D012016:Reference Values
D001971:Bromocriptine