Atrial natriuretic peptide (ANP) in rat gastrointestinal tract.
Acid extracts of rat stomach and small intestine contained 8.6 +/- 3.7 and 39 +/- 15 ng/g of immunoreactive atrial natriuretic peptide (ANP). When studied by gel filtration and reverse-phase high-performance liquid chromatography, the stomach immunoreactivity consisted of multiple components, whereas the small intestine contained mostly proANP and ANP 1-28-like material. These findings indicate that ANP may have a role in the physiology of the gastrointestinal tract, e.g. in the regulation of water and electrolyte absorption.
Vuolteenaho
O
O
Department of Physiology, University of Oulu, Finland.
Arjamaa
O
O
Vakkuri
O
O
Maksniemi
T
T
Nikkilä
L
L
Kangas
J
J
Puurunen
J
J
Ruskoaho
H
H
Leppäluoto
J
J
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000032:analysis*; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D004064:Digestive System / Q000032:analysis*; D007421:Intestine, Small / Q000032:analysis; D008297:Male; D010446:Peptide Fragments / Q000032:analysis; D011498:Protein Precursors / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000032:analysis
D010446:Peptide Fragments; D011498:Protein Precursors; D009320:Atrial Natriuretic Factor