[Human atrial natriuretic factor (hANF) in liver cirrhosis].
Mean plasma levels of hANF at admission were significantly higher in liver cirrhosis (LC) patients with ascites (93 +/- 11 ng, n = 20; p less than 0.05) than in LC-patients without ascites (32 +/- 14 ng/l, n = 11) or healthy controls (31 +/- 15 ng/l; range: 5-80 ng/l; n = 106). Diuretic treatment of patients with LC and ascites normalised hANF plasma concentrations (44 +/- 14 ng/l; p less than 0.05). Increase of plasma hANF in LC-patients with ascites after acute volume expansion was lower (relative rise: 159%) than in those without ascites (relative rise: 223%). Volume redistribution into the vascular compartment, induced by peritoneovenous shunt implantation in LC-patients with diuretic treatment-refractory ascites, resulted in a sharp increase of plasma hANF levels (344 +/- 87 ng/l = 420% of preoperative concentration). Normal and slightly increased levels of plasma hANF and the appropriate regulation to volume changes suggest an intact control of the hormone in LC-patients. Neither a lack nor an inappropriate secretion of hANF as a cause for sodium retention as postulated by the overflow theory of ascites accumulation could be found in liver cirrhosis.
Pidlich
J
J
II. Universitätsklinik für Gastroenterologie und Hepatologie, Wien.
Müller
C
C
Hartter
E
E
Renner
F
F
Klepetko
W
W
Miholic
J
J
Woloszczuk
W
W
D001201:Ascites / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001810:Blood Volume; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010536:Peritoneovenous Shunt; D011183:Postoperative Complications / Q000097:blood; D014882:Water-Electrolyte Balance
C472955:NPPA protein, human; D009320:Atrial Natriuretic Factor
Humaner atrialer natriuretischer Faktor (hANF) bei Leberzirrhose.