Evaluation of 99Tcm mercaptoacetyltriglycine for the detection and localization of gastrointestinal bleeding in an experimental animal model.
Technetium-99m mercaptoacetyltriglycine (99Tcm-MAG3) was evaluated for the detection and localization of the site of gastrointestinal bleeding in a sheep model. Radioactivity was detected in both the stomach and lower abdomen. However, 99Tcm-MAG3 is partially excreted by the liver and in the bile. The radioactivity in the bile moved to the small bowel. This movement of radioactivity in the lower abdomen can lead to a misinterpretation of the site of bleeding. Hence, 99Tcm-MAG3 may not be an effective radiopharmaceutical for the localization of the site of bleeding in the gastrointestinal tract, particularly the lower abdomen.
Owunwanne
A
A
Department of Nuclear Medicine, Faculty of Medicine, Kuwait University.
al-Wafai
I
I
Vallgren
S
S
Sadek
S
S
Abdel-Dayem
H M
HM
Yakoub
T
T
Awdeh
M
M
D000818:Animals; D004195:Disease Models, Animal; D004341:Drug Evaluation; D006471:Gastrointestinal Hemorrhage / Q000000981:diagnostic imaging*; D009842:Oligopeptides; D009942:Organometallic Compounds; D011877:Radionuclide Imaging; D012756:Sheep; D013667:Technetium; D017263:Technetium Tc 99m Mertiatide; D013997:Time Factors
D009842:Oligopeptides; D009942:Organometallic Compounds; D017263:Technetium Tc 99m Mertiatide; D013667:Technetium