title: IgG subclass deficiency in patients with Down's syndrome and aberrant hepatitis B vaccine response.
abstract: Seventeen adult patients with Down's syndrome (DS) and 19 adult healthy references were vaccinated with a hepatitis B vaccine in order to study the IgG subclass response. An enzyme-linked immunosorbent assay (ELISA) using monoclonal antibodies specific for IgG subclasses was employed. In spite of normal levels of total IgG1 and normal or even high levels of IgG3 in the DS patients, a significantly lower IgG1 response to the vaccine was observed in trisomic patients than in the references.
authors.affiliation: Department of Paediatrics, University of Pavia, Italy.
authors.forename: M A
authors.initials: MA
authors.lastname: Avanzini
authors.forename: T
authors.initials: T
authors.lastname: Söderström
authors.forename: M
authors.initials: M
authors.lastname: Wahl
authors.forename: A
authors.initials: A
authors.lastname: Plebani
authors.forename: G R
authors.initials: GR
authors.lastname: Burgio
authors.forename: L A
authors.initials: LA
authors.lastname: Hanson
mesh_terms: D000917:Antibody Formation; D004314:Down Syndrome / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000276:immunology*; D017325:Hepatitis B Vaccines; D006801:Humans; D017099:IgG Deficiency; D007132:Immunoglobulin Isotypes / Q000276:immunology; D007700:Kinetics; D013997:Time Factors; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
chemical_list: D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D007132:Immunoglobulin Isotypes; D014761:Viral Hepatitis Vaccines