title: Toxaphene: accumulation in the adrenal cortex and effect on ACTH-stimulated corticosteroid synthesis in the rat.
abstract: Uptake and distribution of [14C]toxaphene was studied in the adrenals of rats using whole-body autoradiography. An accumulation of radioactivity was seen in the adrenal cortex (zona fasciculata) 1-24 h after a single gavage of [14C]toxaphene (16 mg/kg b.w.). In in vitro studies toxaphene was found to inhibit ACTH-stimulated corticosterone synthesis in the cultured rat adrenocortical cells (IC50 2.8 X 10(-5) M). Moderate but significant inhibition (P less than 0.001) of ACTH-stimulated corticosterone synthesis was also observed in the adrenocortical cells isolated from rats after a prolonged exposure (5 weeks) to low levels (1.2 ppm) of toxaphene in feed. The results indicate a direct adrenotoxic effect of toxaphene.
authors.forename: A
authors.initials: A
authors.lastname: Mohammed
authors.forename: E
authors.initials: E
authors.lastname: Hallberg
authors.forename: J
authors.initials: J
authors.lastname: Rydström
authors.forename: P
authors.initials: P
authors.lastname: Slanina
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism*; D000305:Adrenal Cortex Hormones / Q000096:biosynthesis*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001345:Autoradiography; D005260:Female; D066298:In Vitro Techniques; D007306:Insecticides / Q000633:toxicity*; D051381:Rats; D013997:Time Factors; D014112:Toxaphene / Q000378:metabolism / Q000633:toxicity*
chemical_list: D000305:Adrenal Cortex Hormones; D007306:Insecticides; D014112:Toxaphene; D000324:Adrenocorticotropic Hormone