Expression of CR2 (C3d receptor) on the cell membranes of adult T cell leukemia.
MT-2 cells, which produce human T-cell lymphotropic virus type I (HTLV-I), are known to have a complement receptor. We have established that the complement receptor is CR2 which binds C3d on immune complexes but not CR1. CR2 was also detected on ATL-3I cells but no complement receptor was detected on ATL-1K cells which lack ATL antigen (ATLA). Since CR2 is not detectable on normal T lymphocytes, the presence of CR2 on some ATL cells might suggest that ATL cells were derived from a particular minor lineage of T cells, or HTLV-I has a capacity to induce CR2, which has been demonstrated to be an a-type growth factor for B lymphocytes and to be a receptor for Epstein-Barr virus.
Kai
C
C
Department of Microbiology, Fukuoka University School of Medicine.
Okada
N
N
Okada
H
H
D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis*; D015486:HTLV-I Antigens / Q000032:analysis; D015490:HTLV-I Infections / Q000276:immunology*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology*; D011951:Receptors, Complement / Q000032:analysis*; D017464:Receptors, Complement 3d; D012397:Rosette Formation
D000944:Antigens, Differentiation, B-Lymphocyte; D015486:HTLV-I Antigens; D011951:Receptors, Complement; D017464:Receptors, Complement 3d