[Changes in Na, K-ATPase activity following adrenoreceptor blockade].
A regulatory factor released from the effector cell during blockade of postsynaptic alpha- and beta-adrenoreceptors with phentolamine and propranolol (5 X 10(7)-1 X 10(-6) M) and activating norepinephrine neuronal uptake and synthesis, was shown to activate, Na, K-ATPase of the rat isolated organs as well as the preparation of partly purified Na, K-ATPase extracted from the rat brain. Ouabain (1 X 10(-3) M) eliminated completely the activating effect of the regulatory factor on the ATPase.
Manukhin
B N
BN
Kurbanova
G D
GD
Volina
E V
EV
Erokhov
P A
PA
D000320:Adrenergic Fibers / Q000502:physiology*; D000818:Animals; D006321:Heart / Q000294:innervation; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D014649:Vas Deferens / Q000294:innervation
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D000254:Sodium-Potassium-Exchanging ATPase; D010646:Phentolamine
Izmenenie aktivnosti Na, K-ATFazy pri blokade adrenoretseptorov.