title: HLA-B18 is associated with decreased levels of isoproterenol-stimulated cAMP in lymphocytes.
abstract: One hundred fifty-nine individuals were typed for HLA-A and B antigens and levels of isoproterenol-stimulated, lymphocyte cAMP. No significant age, sex, or caffeine effects on the natural log of the lymphocyte cAMP variable (ln cAMP) were found. A comparison of mean ln cAMP levels between individuals who carried a particular antigen (homozygous or heterozygous) and individuals who did not carry the antigen identified a highly significant decrease in ln cAMP levels associated with the HLA-B18 antigen. We estimated that 18.9% of the variability in ln cAMP was attributable to the HLA-B18 antigen. In addition, 38% of the variability in ln cAMP was attributable to factors that aggregate in families that were independent of the HLA-B18 effect. A weaker association of A10 with lymphocyte cAMP might be due to linkage disequilibrium between A10 and B18.
authors.forename: R P
authors.initials: RP
authors.lastname: Erickson
authors.forename: G L
authors.initials: GL
authors.lastname: Pairitz
authors.forename: J M
authors.initials: JM
authors.lastname: Karolyi
authors.forename: J J
authors.initials: JJ
authors.lastname: Kapur
authors.forename: D J
authors.initials: DJ
authors.lastname: Odenheimer
authors.forename: J S
authors.initials: JS
authors.lastname: Schultz
authors.forename: C F
authors.initials: CF
authors.lastname: Sing
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002972:Cleft Palate / Q000097:blood / Q000235:genetics; D000242:Cyclic AMP / Q000235:genetics* / Q000378:metabolism; D003550:Cystic Fibrosis / Q000097:blood / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059911:HLA-B18 Antigen; D006801:Humans; D007223:Infant; D007545:Isoproterenol / Q000494:pharmacology*; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D005819:Genetic Markers; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059911:HLA-B18 Antigen; D000242:Cyclic AMP; D007545:Isoproterenol