Induction of tumors with cycasin in newborn and preweanling rats.
Comprehensive studies of carcinogenesis in newborn or preweanling SD rats were conducted under various dose schedules of cycasin (CAS: 14901-08-7) administration. When cycasin was given sc to newborn rats at day 0, tumors were detected in more than 80% of rats of both sexes; kidney tumors were by far the most common. The incidences of tumors declined in the older groups, namely, over 60% in both sexes in the 7-day group, 55% in males and 8.3% in females in 14-day rats, and 0% in 21-day groups. By multiple administration, tumor incidences elevated considerably. Administration ip of cycasin also gave rise to tumor induction in newborn rats. A total of 435 kidney tumors found in the experiments were studied pathologically. Most of them were classified as mesenchymal tumor; some of them metastasized. A few other tumors were found in the liver and colon.
Fukunishi
R
R
Kadota
A
A
Yoshida
A
A
Hirota
N
N
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D001391:Azo Compounds; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000473:pathology; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000473:pathology; D003492:Cycasin; D005260:Female; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008637:Mesenchymoma / Q000139:chemically induced / Q000473:pathology; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D001391:Azo Compounds; D003492:Cycasin