T4 cell receptor distortion in acquired immune deficiency syndrome.
Among the possible affects of the HIV virus on T-cells in Acquired Immune Deficiency Syndrome is the cell membrane distortion of the T4 cell protein receptor for Genetically Related Macrophage Factor (GRF). The integrity of this specific T-cell receptor takes on profound significance due to its relationship to soluble antigen. Alpha-tocopheral has been shown to assist in the maintenance of cell membrane structure and may have application in a strategy of membrane restoration. Adoptive Transfer, a method of immune cell alteration applicable in anti-tumor therapy, may play a role in the mechanics of such a strategy.
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D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000954:Antigens, Surface / Q000032:analysis*; D006801:Humans; D008264:Macrophages / Q000032:analysis / Q000276:immunology; D008560:Membrane Fluidity / Q000187:drug effects; D015728:Receptors, HIV; D011971:Receptors, Immunologic / Q000032:analysis; D011991:Receptors, Virus / Q000032:analysis*; D006377:T-Lymphocytes, Helper-Inducer / Q000032:analysis / Q000187:drug effects; D014810:Vitamin E / Q000494:pharmacology
D000954:Antigens, Surface; D015728:Receptors, HIV; D011971:Receptors, Immunologic; D011991:Receptors, Virus; D014810:Vitamin E