[Specific binding of 3H-naloxone with isolated rat enterocytes].
Specific 3H-naloxone binding with isolated rat enterocytes has been demonstrated. This binding was selectively inhibited by different opiates and proved to be irreversible, temperature-dependent and sodium azide-sensitive. The presence of naloxone binding sites on enterocytes indicates a possible involvement of opiates in the regulation of enterocyte functions.
Iarygin
K N
KN
Sviridov
D D
DD
Shitin
A G
AG
Vinogradov
V A
VA
Titov
M I
MI
D000818:Animals; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008024:Ligands; D008297:Male; D009270:Naloxone / Q000378:metabolism*; D009294:Narcotics / Q000494:pharmacology; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism*; D014316:Tritium
D008024:Ligands; D009294:Narcotics; D011957:Receptors, Opioid; C034565:naloxone receptor; D014316:Tritium; D009270:Naloxone
Spetsificheskoe sviazyvanie 3H-naloksona s izolirovannymi énterotsitami krys.