The effect of atrial natriuretic factor on urinary albumin and beta 2-microglobulin excretion in man.
The effect of a 20-min infusion of atrial natriuretic factor (ANF) 99-126, 0.4 microgram/kg per min, on both urinary albumin and beta 2-microglobulin excretion was examined in nine normal male subjects during stable water diuresis. ANF caused a rise in urinary albumin in excretion (from 4.19 +/- 0.66 to 13.49 +/- 3.07 ng/min, P less than 0.01) without any significant change in either creatinine clearance of beta 2-microglobulin excretion. These findings suggest that ANF may enhance glomerular permeability to albumin in man.
McMurray
J
J
Department of Clinical Pharmacology, Ninewells Hospital, Medical School, Dundee, Scotland, UK.
Seidelin
P H
PH
Howey
J E
JE
Balfour
D J
DJ
Struthers
A D
AD
D000328:Adult; D000419:Albuminuria / Q000652:urine*; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D004231:Diuresis; D004232:Diuretics / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D013268:Stimulation, Chemical; D001613:beta 2-Microglobulin / Q000652:urine*
D004232:Diuretics; D010446:Peptide Fragments; D001613:beta 2-Microglobulin; D009320:Atrial Natriuretic Factor