title: Adenosine receptors on human inflammatory cells.
abstract: Adenosine is a natural nucleoside that plays a physiological role in the modulation of human inflammatory cells. We have investigated the presence of adenosine A2/Ra and A1/Ri receptors and of the P-site on human inflammatory cells. Human B and T(OKT4+ and OKT8+) lymphocytes, polymorphonuclear leucocytes, monocytes, basophils and platelets possess a membrane adenosine A2/Ra receptor. The activation of adenosine A2/Ra receptor increases the intracellular level of cyclic AMP in these cells. Human lymphocytes and neutrophils possess also an inhibitory adenosine A1/Ri receptor and a P-site whose activation inhibits the effect of many adenylate cyclase agonists including isoproterenol, PGE1, histamine, adenosine, cholera toxin and forskolin.
authors.forename: G
authors.initials: G
authors.lastname: Marone
authors.forename: R
authors.initials: R
authors.lastname: Petracca
authors.forename: S
authors.initials: S
authors.lastname: Vigorita
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*; D000262:Adenylyl Cyclases / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology*; D011983:Receptors, Purinergic
chemical_list: D011956:Receptors, Cell Surface; D011983:Receptors, Purinergic; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D000241:Adenosine