title: [Contrast media in magnetic resonance tomography. A review. 1. Physicochemical and pharmacological bases of MR contrast media using gadolinium-DTPA as an example].
abstract: The principles underlying contrast media for MR tomography are totally different from those for conventional contrast media. Substances suitable for MR tomography are paramagnetic complexes which alter the relaxation times of the tissues. Signal intensity on the MR images are influenced correspondingly. The mode of action of MR contrast media is explained. Gadolinium-DTPA, the first MR contrast medium in clinical use by means of intravenous injection, is described. Its tolerance has been investigated by animal experiments and its effectiveness as an contrast agent has been studied in normal individuals. In the second part of the paper, early results from the use of gadolinium DTPA are given. The additional information which can be obtained by using MR contrast media is discussed.
authors.forename: R
authors.initials: R
authors.lastname: Felix
authors.forename: W
authors.initials: W
authors.lastname: Semmler
authors.forename: W
authors.initials: W
authors.lastname: Schörner
authors.forename: M
authors.initials: M
authors.lastname: Laniado
mesh_terms: D000818:Animals; D003287:Contrast Media; D006801:Humans; D007668:Kidney / Q000033:anatomy & histology; D009682:Magnetic Resonance Spectroscopy; D004369:Pentetic Acid / Q000633:toxicity; D001743:Urinary Bladder / Q000033:anatomy & histology
chemical_list: D003287:Contrast Media; D004369:Pentetic Acid
vernacular_title: Kontrastmittel in der magnetischen Resonanztomographie. Eine Ubersicht. Teil 1: Physiko-chemische und pharmakologische Grundlagen von MR-Kontrastmitteln am Beispiel von Gadolinium-DTPA.