Lymphoma of host origin in a marrow transplant recipient in remission of acute myeloid leukemia and receiving cyclosporin A.
Lymphomas are an uncommon complication of solid organ transplantation and rarely occur after marrow transplantation. When post-marrow transplant lymphomas have occurred, they have been of donor cell origin and when sought, Epstein-Barr virus DNA has been found in the tumor. A 21-year-old woman developed a poorly differentiated lymphocytic lymphoma 6 months after bone marrow transplantation for acute myeloid leukemia in remission. Cyclosporin A had been used as an immunosuppressant. A chromosomal polymorphism demonstrated that the tumor was of host origin and contained a monoclonal tumor marker, 46,XX INV 4 (p16q12). The tumor did not contain the DNA of the Epstein-Barr virus.
Bloom
R E
RE
Brennan
J K
JK
Sullivan
J L
JL
Chiganti
R S
RS
Dinsmore
R
R
O'Reilly
R
R
D000017:ABO Blood-Group System; D000328:Adult; D016026:Bone Marrow Transplantation; D003524:Cyclosporins / Q000627:therapeutic use; D004279:DNA, Viral; D005260:Female; D005455:Fluorescent Antibody Technique; D004854:Herpesvirus 4, Human; D006651:Histocytochemistry; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000032:analysis; D007147:Immunoglobulin Light Chains / Q000032:analysis; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology; D008223:Lymphoma / Q000209:etiology*; D008677:Metaphase; D009693:Nucleic Acid Hybridization
D000017:ABO Blood-Group System; D003524:Cyclosporins; D004279:DNA, Viral; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains