Reduced collagen biosynthesis in oral mucosa of beige (Chediak-Higashi) mice.
Oral mucosa of beige (Chediak-Higashi) mice had decreased levels of collagen synthesis and prolyl hydroxylase activity compared with normal animals. No significant difference was observed in non-collagen protein synthesis between the two groups. These results suggest that decreased collagen biosynthesis in oral tissues may be partially involved in the increased incidence of periodontal disease in the Chediak-Higashi syndrome.
Shikata
H
H
Hiramatsu
M
M
Ikeda
K
K
Utsumi
N
N
Asano
T
T
Shikata
T
T
D000818:Animals; D002609:Chediak-Higashi Syndrome / Q000150:complications / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009061:Mouth Mucosa / Q000378:metabolism*; D010510:Periodontal Diseases / Q000209:etiology; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism
D003094:Collagen; D011393:Procollagen-Proline Dioxygenase