title: Comparison of the biopotencies of nicotinic acid and nicotinamide for broiler chicks.
abstract: 1. Two experiments were conducted with 1056 1-d-old Cobb x Cobb feather-sexed broiler chicks, to determine the relative nicotinic acid biopotencies of nicotinic acid (NA) and nicotinamide (NAm). 2. Two methods were used: the slope-ratio technique and the broken-line model. 3. In experiment 1, using the slope-ratio technique, NAm was 0.82 as active as NA in promoting growth to 21 d of age. In experiment 2 NAm was 0.96 as bipotent as NA. 4. Applying the broken-line model to the body weight data at 21 d of age for both NA and NAm in experiment 1, it was found that NAm had approximately 0.82 NA activity. The same analysis applied to the data of experiment 2 indicated that the biopotency of NAm was 1.09. 5. A t-test of the slope-ratio values obtained in both experiments indicated that the average (0.89) was not significantly different from 1.0. 6. It was concluded that the relative biopotencies of NA and NAm in broiler chicks fed a maize-soyabean meal diet were similar.
authors.affiliation: Department of Poultry Science, University of Florida, Gainesville 32611.
authors.forename: N
authors.initials: N
authors.lastname: Ruiz
authors.forename: R H
authors.initials: RH
authors.lastname: Harms
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002645:Chickens / Q000254:growth & development*; D005260:Female; D008297:Male; D009525:Niacin / Q000494:pharmacology*; D009536:Niacinamide / Q000494:pharmacology*; D012062:Relative Biological Effectiveness
chemical_list: D009536:Niacinamide; D009525:Niacin