title: Human factor H (beta 1H-globulin): linkage analysis.
abstract: Linkage data on human factor H (HF) and 22 other human genetic markers are presented. Close linkage at theta less than 0.10 can be ruled out for a series of marker systems (Rh, PGM1, ACP1, Jk, Tf, Gc, MNSs, ME2, HLA, GLO1, ORM, Gt, PI, Hp, GPT). Strong evidence for linkage was obtained for peptidase A (PEPA) with lods greater than 3.0 at theta = 0.10 in males and at theta = 0.20 for the sexes combined. From this result the HF locus can be provisionally assigned to chromosome 18.
authors.affiliation: Institut für Anthropologie und Humangenetik der Universität, Tübingen, Federal Republic of Germany.
authors.forename: J
authors.initials: J
authors.lastname: Kömpf
authors.forename: C
authors.initials: C
authors.lastname: Luckenbach
authors.forename: D
authors.initials: D
authors.lastname: Kloor
authors.forename: F
authors.initials: F
authors.lastname: Schunter
authors.forename: P
authors.initials: P
authors.lastname: Wernet
authors.forename: H
authors.initials: H
authors.lastname: Ritter
mesh_terms: D003180:Complement C3b Inactivator Proteins / Q000235:genetics*; D017242:Complement Factor H; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans
chemical_list: C493495:CFH protein, human; D003180:Complement C3b Inactivator Proteins; D005819:Genetic Markers; D017242:Complement Factor H