Thiamin status of the offspring of diabetic rats.
Erythrocyte transketolase activity and thiamin pyrophosphate effect were examined in the offspring of streptozotocin-diabetic rats. Thiamin reserve was found to be significantly reduced in litters of untreated diabetic rats as compared to control and to insulin-treated diabetic rats. Supplementation of the untreated diabetic dams throughout pregnancy with oral thiamin was associated with a significantly improved thiamin status of the litters. We conclude that, due to enhanced fetal glucose turnover during diabetic gestation, a fetal thiamin deficiency state may evolve; this condition can be remedied with maternal thiamin supplementation.
Berant
M
M
Department of Pediatrics, Rambam Medical Center, Haifa, Israel.
Berkovitz
D
D
Mandel
H
H
Zinder
O
O
Mordohovich
D
D
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000188:drug therapy; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D007328:Insulin / Q000627:therapeutic use; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000188:drug therapy / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin; D013831:Thiamine / Q000097:blood* / Q000627:therapeutic use; D013832:Thiamine Deficiency / Q000097:blood* / Q000209:etiology; D013834:Thiamine Pyrophosphatase / Q000097:blood; D014174:Transketolase / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D013311:Streptozocin; D014174:Transketolase; D013834:Thiamine Pyrophosphatase; D013831:Thiamine