title: Radiation-induced decomposition of the purine bases within DNA and related model compounds.
abstract: This survey focuses on recent developments in the radiation chemistry of purine bases in nucleic acids and related model compounds. Both direct and indirect effects of ionizing radiation are investigated with special emphasis on the structural characterization of the final decomposition products of nucleic acid components. Available assays for monitoring radiation-induced base lesions are critically reviewed.
authors.forename: J
authors.initials: J
authors.lastname: Cadet
authors.forename: M
authors.initials: M
authors.lastname: Berger
mesh_terms: D000225:Adenine / Q000528:radiation effects; D000249:Adenosine Monophosphate / Q000528:radiation effects; D004247:DNA / Q000528:radiation effects*; D003839:Deoxyadenosines / Q000528:radiation effects; D003849:Deoxyguanosine / Q000528:radiation effects; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D006878:Hydroxides; D011687:Purines / Q000528:radiation effects*; D011854:Radiochemistry
chemical_list: D003839:Deoxyadenosines; D005609:Free Radicals; D006878:Hydroxides; D011687:Purines; D000249:Adenosine Monophosphate; D004247:DNA; D003849:Deoxyguanosine; D000225:Adenine