Sequence homologies in the control regions of c-myc, c-fos, HTLV and the interleukin-2 receptor.
Homologies in the control regions of 2 cellular oncogenes have been identified in this study. Both oncogenes (c-myc and c-fos) are known to be transiently induced by mitogens. We suggest that transcriptional activators bind to these putative control sequences, thus de-regulating gene expression in a coordinated and cell-cycle specific manner. In addition, we report on homologous sequences in the control regions of the human T-cell leukemia viruses types I and II, and in the flanking region of the gene coding for the interleukin-2 receptor. These, and other experimental data, lead to the formation of a model in terms of which the unlimited proliferation of cells infected with HTLV-I and -II may be explained. The differing biological effects of HTLV-I, -II and -III are also examined and discussed at a molecular level.
Renan
M J
MJ
D001483:Base Sequence; D002471:Cell Transformation, Neoplastic; D017977:Deltaretrovirus / Q000235:genetics*; D005786:Gene Expression Regulation; D009857:Oncogenes; D011971:Receptors, Immunologic / Q000235:genetics*; D015375:Receptors, Interleukin-2; D012091:Repetitive Sequences, Nucleic Acid; D014764:Viral Proteins / Q000032:analysis*
D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D014764:Viral Proteins