The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.
The study of human hematopoietic cells and the human immune system is hampered by the lack of a suitable experimental model. Experimental data are presented showing that human fetal liver hematopoietic cells, human fetal thymus, and human fetal lymph node support the differentiation of mature human T cells and B cells after engraftment into mice with genetically determined severe combined immunodeficiency. The resultant SCID-hu mice are found to have a transient wave of human CD4+ and CD8+ T cells and human IgG (immunoglobulin G) in the peripheral circulation. The functional status of the human immune system within this mouse model is not yet known.
McCune
J M
JM
Department of Radiation Oncology, Stanford University School of Medicine, CA 94305.
Namikawa
R
R
Kaneshima
H
H
Shultz
L D
LD
Lieberman
M
M
Weissman
I L
IL
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology; D002454:Cell Differentiation; D002678:Chimera; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000166:cytology; D016031:Liver Transplantation; D008198:Lymph Nodes / Q000637:transplantation; D051379:Mice; D008817:Mice, Mutant Strains / Q000276:immunology*; D008954:Models, Biological; D013601:T-Lymphocytes / Q000502:physiology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013950:Thymus Gland / Q000033:anatomy & histology / Q000502:physiology / Q000637:transplantation; D014183:Transplantation, Heterologous