[Effect of lithium chloride on thyroid structural elements in the rat and on the balance of calcitropic hormones].
Chronic experiments were performed to study the effect of lithium chloride on morphological and functional characteristics of rat thyroid and on the endocrine regulation of calcium metabolism. As a result of a prolonged exposure to low doses of lithium the thyroid manifests the signs of activation of tissue structures. As the lithium dose is raised, the thyrostatic effect of lithium occurs according to the mechanism similar to the Wolff-Chaikoff effect (colloid accumulation by follicles and suppression of hormones secretion into blood). Lithium chloride stimulates calcitonin production by C cells of the thyroid. However, the increase of the basal level of calcitonin has no substantial effect on calcium metabolism in the animals, since such an increase is accompanied by increment of the production of the physiological antagonist parathyroid hormone by the secretory cells of the parathyroid glands.
Petrov
N M
NM
Semenov
V V
VV
Glumova
V A
VA
D000818:Animals; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000378:metabolism*; D002712:Chlorides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects* / Q000503:physiopathology; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood / Q000494:pharmacology
D002712:Chlorides; D010281:Parathyroid Hormone; D013963:Thyroid Hormones; D013972:Thyrotropin; D002116:Calcitonin; D008094:Lithium; D018021:Lithium Chloride; D002118:Calcium
Vliianie khlorida litia na strukturnye élementy shchitovidnoĭ zhelezy krysy i balans kal'tsitropnykh gormonov.