Effect of the vasodilator peptides calcitonin gene-related peptide and atriopeptin on rabbit microvascular blood flow. Preliminary communication.
A neuropeptide known as calcitonin gene-related peptide (CGRP) has been shown to have vasodilatory properties in the rabbit epigastric island flap of almost equivalent potency to prostacyclin. The latter is currently regarded as the most potent vasodilator yet to be isolated. CGRP, with its longer-lasting effect in blood and its ability to overcome noradrenaline-induced vasospasm, may be promising for use during or after ischaemic flap transfer or replantation. Another known vasodilatory peptide, atriopeptin, was not as potent in the microvascular bed of the cutaneous flap as in major blood vessels.
Knight
K R
KR
Microsurgery Research Centre, St Vincent's Hospital, Melbourne, Australia.
Martin
T J
TJ
Coe
S A
SA
O'Brien
B M
BM
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D015740:Calcitonin Gene-Related Peptide; D008833:Microcirculation / Q000187:drug effects; D009479:Neuropeptides / Q000494:pharmacology*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D013524:Surgical Flaps; D014665:Vasodilator Agents / Q000494:pharmacology*
D009479:Neuropeptides; D014665:Vasodilator Agents; D009320:Atrial Natriuretic Factor; D015740:Calcitonin Gene-Related Peptide