Modulation of protein kinases and phosphoprotein phosphatases by a small acidic protein from bovine brains.
A small, acidic and heat-stable protein was purified from bovine brains by column chromatography on DEAE-cellulose, Bio-Gel HTP, Affi-Gel phenothiazine and Sephadex G-75. This protein stimulates megamodulin-dependent protein kinase I from brains and phosphoprotein phosphatases from either brain or yeast. However, it inhibits cyclic AMP-dependent protein kinases from skeletal muscle.
Kuo
W N
WN
Liu
L P
LP
Rahmani
M A
MA
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002413:Cations, Divalent; D002417:Cattle; D004789:Enzyme Activation; D006358:Hot Temperature; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000302:isolation & purification* / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism*
D002413:Cations, Divalent; D009419:Nerve Tissue Proteins; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases