[Pharmacokinetics of ceftazidime in the cerebrospinal fluid].
A compound potentially effective in the treatment of meningitis should reach high concentrations in CSF. In animal experimental models, ceftazidime levels of 5-25 micrograms/ml were demonstrated during administration of doses generating serum levels similar to those achieved in humans. Human studies later confirmed CSF levels of 5-10 micrograms/ml in patients with meningitis. Ceftazidime CSF kinetic properties are adequate for use of this compound in patients with meningitis due to susceptible organisms.
Decazes
J M
JM
Clinique des Maladies infectieuses, Hôpital Saint-Louis, Paris.
D000818:Animals; D002442:Ceftazidime / Q000097:blood / Q000134:cerebrospinal fluid*; D004927:Escherichia coli Infections / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D008581:Meningitis / Q000097:blood / Q000134:cerebrospinal fluid*; D008583:Meningitis, Haemophilus / Q000097:blood / Q000134:cerebrospinal fluid; D008586:Meningitis, Pneumococcal / Q000097:blood / Q000134:cerebrospinal fluid
D002442:Ceftazidime
Pharmacocinétique de la ceftazidime dans le liquide céphalorachidien.