title: The thromboxane receptor antagonist, daltroban, protects the myocardium from ischaemic injury resulting in suppression of leukocytosis.
abstract: The cardioprotective action of the new selective inhibitor of thromboxane receptors, daltroban (BM 13.505), was studied in cats subjected to 3 h of coronary artery ligation followed by 2 h of reperfusion. In comparison with vehicle (physiological saline)-treated cats, daltroban (20 mg/kg per h i.v.) reduced the ischaemia-induced rise in the ST segment and prevented the development of a Q-wave in the ECG during reperfusion. This was paralleled by a significantly improved preservation of creatine-phosphokinase activity in the ischaemic myocardium. Daltroban significantly attenuated platelet ATP secretion, the U-46.619-induced contraction of the cat thoracic aorta ex vivo and the myeloperoxidase-associated generation of reactive oxygen species ex vivo. These effects could be largely attributed to the inhibition of ischaemia-induced leukocytosis. It is concluded that daltroban protects the myocardium from ischaemic injury and that this effect involves prevention of ischaemia-induced leukocytosis.
authors.affiliation: Institut für Pharmakologie, Universität Düsseldorf, F.R.G.
authors.forename: C
authors.initials: C
authors.lastname: Thiemermann
authors.forename: P
authors.initials: P
authors.lastname: Ney
authors.forename: K
authors.initials: K
authors.lastname: Schrör
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002415:Cats; D003327:Coronary Disease / Q000503:physiopathology / Q000517:prevention & control*; D003402:Creatine Kinase / Q000378:metabolism; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D007964:Leukocytosis / Q000209:etiology* / Q000517:prevention & control; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010100:Oxygen / Q000097:blood; D010648:Phenylacetates / Q000494:pharmacology*; D010976:Platelet Count; D011982:Receptors, Prostaglandin / Q000378:metabolism; D017482:Receptors, Thromboxane; D013449:Sulfonamides / Q000494:pharmacology*; D013931:Thromboxanes / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
chemical_list: D010648:Phenylacetates; D011982:Receptors, Prostaglandin; D017482:Receptors, Thromboxane; D013449:Sulfonamides; D013931:Thromboxanes; D000255:Adenosine Triphosphate; D003402:Creatine Kinase; C051762:daltroban; D010100:Oxygen