title: The cryopreserved homograft valve in the pulmonary position: early results and technical considerations.
abstract: Since September, 1985, 20 patients have undergone implantation of a homograft valve in the pulmonary position (16 pulmonary, 4 aortic). There were 11 primary operations and 9 reoperations. In 7 of 11 primary operations the homograft valve was utilized as a composite conduit with a short Dacron extension. In four of five reoperations for a failed porcine valved conduit, a composite homograft conduit was used. Four patients underwent implantation of a free homograft in a previously repaired right ventricular outflow tract (RVOT). Age ranged from 15 days to 22 years. There was one operative death (5%), a seven-week-old infant with truncus arteriosus. Long-term follow-up ranges from 1 to 30 months. Clinical performance has been satisfactory in 18 of 19 patients. One patient undergoing free implantation of a pulmonary valve in the RVOT required replacement at 18 months with a porcine valve. In this patient, pulmonary insufficiency was caused by distortion of the annulus secondary to dilatation and pulmonary hypertension. Nine of 18 survivors do not require medication. Eleven of 18 have trivial to mild pulmonary insufficiency murmurs without symptomatology. The homograft valve is extremely useful in reconstruction of the right heart, however, early insufficiency murmurs have been noted. Distortion of the valve annulus may contribute to the early onset of a benign insufficiency murmur. Residual distal obstruction or pulmonary hypertension may be a contraindication to the use of a free homograft in the orthotopic position.
authors.affiliation: Division of Cardiology, Children's Hospital and Health Center, San Diego, California.
authors.forename: J J
authors.initials: JJ
authors.lastname: Lamberti
authors.forename: W W
authors.initials: WW
authors.lastname: Angell
authors.forename: J D
authors.initials: JD
authors.lastname: Waldman
authors.forename: T M
authors.initials: TM
authors.lastname: Grehl
authors.forename: L
authors.initials: L
authors.lastname: George
authors.forename: J W
authors.initials: JW
authors.lastname: Mathewson
authors.forename: S E
authors.initials: SE
authors.lastname: Kirkpatrick
authors.forename: R
authors.initials: R
authors.lastname: Spicer
authors.forename: D
authors.initials: D
authors.lastname: Thomson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002140:California / Q000453:epidemiology; D006348:Cardiac Surgical Procedures / Q000379:methods / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D015925:Cryopreservation / Q000592:standards*; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000601:surgery*; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000401:mortality; D011664:Pulmonary Valve / Q000637:transplantation*; D012086:Reoperation / Q000706:statistics & numerical data; D015996:Survival Rate; D014184:Transplantation, Homologous / Q000592:standards*