[Effects of 3,5,3'-triiodo-L-thyronine on the enzymes responsible for the metabolism of xenobiotics in the rat after increase in the dietary supply of cholesterol].
A cholesterol rich diet fed to rats was found to increase the cytochrome P 450 content in hepatic microsomes. Furthermore, the variations of the same parameters promoted by 3,5,3'-triiodo-L-thyronine were strongly reduced in cholesterol supplemented rats. Cholesterol prevented the inducing effects of phenobarbital but did not oppose its decreasing effect on maximal fluorescence of ANS and PNA introduced into the microsome suspensions.
Mounié
J
J
Formation de Biochimie pharmacologique, Facultés de Médecine et de Pharmacie, Dijon.
Goudonnet
H
H
Serrar
M
M
Escousse
A
A
Truchot
R C
RC
D000818:Animals; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006980:Hyperthyroidism / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014284:Triiodothyronine / Q000494:pharmacology*; D015262:Xenobiotics / Q000378:metabolism*
D002791:Cholesterol, Dietary; D015262:Xenobiotics; D014284:Triiodothyronine; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital
Effets de la 3,5,3'-triiodo-L-thyronine sur les enzymes responsables du métabolisme des xénobiotiques chez le Rat aprés augmentation de l'apport alimentaire en cholestérol.