title: [Inhibition of mitochondrial respiration by mepivacaine].
abstract: In the last years our researches on neurotropic drugs follow our hypothesis that the strong effects on nervous system have always hidden more widespread effects on all tissues and cells. It is often required to employ local anesthetics in practising dentistry and orthodontics, particularly when children have to be treated. We have assayed in vitro one of these dental anesthetics, mepivacaine, on liver rat mitochondria: it depresses the respiration coupled to phosphorylation in mitochondria having a good respiratory control; so respiratory control too is depressed, but P/O ratio is unaffected; also respiration uncoupled by 2.4-dinitrophenol is depressed. Depressing respiration cooperates with anesthesia; unchanging P/O is good for the health of the cells and tissues treated by the mepivacaine.
authors.affiliation: Seconda Cattedra di Chimica Biologica de l'Université de Pavie, Faculté de Médecine, Italie.
authors.forename: F
authors.initials: F
authors.lastname: di Jeso
authors.forename: A
authors.initials: A
authors.lastname: Truscello
authors.forename: G
authors.initials: G
authors.lastname: Martinotti
authors.forename: S
authors.initials: S
authors.lastname: Colli
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D004140:Dinitrophenols / Q000494:pharmacology; D008619:Mepivacaine / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats
chemical_list: D004140:Dinitrophenols; D000244:Adenosine Diphosphate; D008619:Mepivacaine
vernacular_title: Inhibition de la respiration mitochondriale par la mépivacaïne.