The structure of amphotericin A. II. The complete structure of the antibiotic.
The structure of amphotericin A without the configuration of asymmetric carbon atoms has been elucidated. The stereochemistry of the sugar moiety has been determined. On the basis of homoscalar correlated 2D 1H spectra. of amphotericin A the position of the hemiketal moiety has been located, and the chemical shifts of all the protons in the antibiotic molecule have been determined.
Sowiński
P
P
Pawlak
J K
JK
Borowski
E
E
Iwashita
T
T
D000666:Amphotericin B / Q000031:analogs & derivatives*; D002241:Carbohydrates / Q000302:isolation & purification; D055598:Chemical Phenomena; D002621:Chemistry; D004735:Energy Transfer; D009682:Magnetic Resonance Spectroscopy; D011522:Protons; D013329:Structure-Activity Relationship
D002241:Carbohydrates; D011522:Protons; C041989:amphotericin A; D000666:Amphotericin B