Comparative studies of some semisynthetic K-strophanthins with natural cardiac glycosides.
In this study the pharmacological effects of seven semisynthetic cardenolides have been investigated and compared with those of 11 natural cardiac glycosides. These compounds are of different potency on electrically driven isolated guinea-pig atria. Their concentration response curves showed different slopes, which could be an indication of varying therapeutic range. The pharmacodynamics of these compounds on isolated guinea-pig atria are in good correlation with the data obtained from binding studies on guinea-pig ventricular homogenate as well as that obtained from comparative experiments on Na+,K+-ATPase activity inhibition.
Tawfik
H
H
Fox
A A
AA
Greeff
K
K
D000818:Animals; D002301:Cardiac Glycosides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010042:Ouabain / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013328:Strophanthins / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D002301:Cardiac Glycosides; D013328:Strophanthins; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase; C029082:strophanthin K