Participation of serotonergic mechanisms in the anticonvulsant effect of stress in mice treated with pentylenetetrazol.
This study analyzed the effects of p-chlorophenylalanine (PCPA) and methysergide pretreatments on prolongation of latency to pentylenetetrazol (PTZ)-induced convulsions in mice submitted to cold/restraint or swim stress. Both anti-5HT agents shortened convulsion latency in non-stressed animals. The effects of cold/restraint and swim stress were markedly suppressed by methysergide. PCPA did not modify the effect of cold/restraint but tended to antagonize that of swim stress. Serotonergic mechanisms possibly exert a tonic inhibitory influence on PTZ-induced convulsions and are important in the manifestation of prolongation of convulsive latency determined by swimming and, possibly, cold/restraint stress.
De-Lima
T C
TC
Departamento de Farmacologia, Universidade Federal de Santa Catarina, Florianópolis, Brasil.
Rae
G A
GA
D000818:Animals; D003080:Cold Temperature; D010134:Fenclonine / Q000494:pharmacology*; D008297:Male; D008784:Methysergide / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D010433:Pentylenetetrazole; D012149:Restraint, Physical; D012640:Seizures / Q000139:chemically induced / Q000209:etiology*; D013312:Stress, Physiological / Q000150:complications*; D013550:Swimming
D010134:Fenclonine; D010433:Pentylenetetrazole; D008784:Methysergide