title: Dehydroepiandrosterone sulfate in saliva.
abstract: Concentrations of dehydroepiandrosterone sulfate (DHAS) in saliva and serum were determined in 11 healthy men aged 23-40 yrs, 55 healthy, non-medicated women aged 20-81 yrs and 13 healthy women aged 20-30 yrs, all taking combined oral contraceptives (OC). Serum DHAS was higher in men than in women of corresponding age and was negatively correlated to age in OC-free women. These sex- and age-related differences were not found for salivary DHAS. Salivary and serum DHAS values were poorly correlated and the ratios between salivary and serum DHAS were variable, with a tendency to higher values in older subjects. Low saliva/serum DHAS ratios were found in OC users. The lack of a uniform, unequivocal relation between DHAS concentrations in saliva and serum renders salivary DHAS assays unsuitable for clinical purposes.
authors.affiliation: Department of Obstetrics and Gynecology, Karolinska Institutet, Huddinge University Hospital, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Lagrelius
authors.forename: M
authors.initials: M
authors.lastname: Fridström
authors.forename: G
authors.initials: G
authors.lastname: Möllerström
authors.forename: K
authors.initials: K
authors.lastname: Carlström
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000032:analysis; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000032:analysis*; D012737:Sex Factors
chemical_list: D003277:Contraceptives, Oral, Combined; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate