A histological and immunocytochemical study of early acne lesions.
We examined 69 biopsies of acne lesions known to be 6, 24 or 72 h old and found that the lymphocyte was the predominant cell at 6 and 24 h. The helper:suppressor T cell ratio in the inflammatory infiltrate was 2.8:1. Polymorphonuclear leukocytes were increasingly seen at 24 and 72 h and were associated with disruption of the duct. We hypothesize that this early lymphocytic infiltrate represents a cell mediated immune response to an antigen within the duct lumen.
Norris
J F
JF
Department of Dermatology, General Infirmary, Leeds, U.K.
Cunliffe
W J
WJ
D000152:Acne Vulgaris / Q000276:immunology* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007150:Immunohistochemistry; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D012867:Skin / Q000276:immunology* / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer; D050378:T-Lymphocytes, Regulatory; D013997:Time Factors