Inhibition of aldosterone production by alpha-human atrial natriuretic polypeptide is associated with an increase in cGMP production.
Synthetic alpha-human atrial natriuretic polypeptide caused rapid and marked inhibition of aldosterone production in dispersed rat adrenal capsular cells. The polypeptide also slightly, but significantly, decreased cAMP production in the adrenal dispersed capsular cells, while markedly stimulating cGMP production. The cGMP production was accelerated at the concentration of alpha-human atrial natriuretic polypeptide lower than the threshold level to stimulate aldosterone production. These findings suggest that alpha-human atrial natriuretic polypeptide possibly plays a regulatory role in aldosterone production and an additional role in natriuresis through inhibition of aldosterone production. The stimulation of cGMP production by alpha-human atrial natriuretic polypeptide may be involved in the inhibitory effect of this peptide on aldosterone production.
Matsuoka
H
H
Ishii
M
M
Sugimoto
T
T
Hirata
Y
Y
Sugimoto
T
T
Kangawa
K
K
Matsuo
H
H
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000450:Aldosterone / Q000096:biosynthesis*; D000818:Animals; D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP / Q000096:biosynthesis*; D005260:Female; D007700:Kinetics; D000451:Mineralocorticoid Receptor Antagonists; D009124:Muscle Proteins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000451:Mineralocorticoid Receptor Antagonists; D009124:Muscle Proteins; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP