On the origin and control of C3NeF.
Nephritic factors are a relatively recent addition to the growing list of autoantibodies. C3NeF was the first of these to be described and acts by stabilizing the alternative pathway C3/C5 convertase. IgG and IgM C3NeF as well as anti-idiotypic antibody to C3NeF, may be found in normal individuals at all ages. In addition, internal image anti-idiotypic antibody can also be demonstrated in patients with glomerulonephritis. Thus, C3NeF appears to fulfill all of the criteria for being a product of normal B-cell function. The potential dysregulation of this process and the role of C3NeF in glomerulonephritis remains theoretical at best.
Spitzer
R E
RE
Department of Pediatrics, SUNY Health Science Center, Syracuse 13210.
Stitzel
A E
AE
D001323:Autoantibodies / Q000096:biosynthesis*; D015432:Glomerulonephritis, Membranoproliferative / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D012016:Reference Values
D001323:Autoantibodies