Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless.
An expressed gene sequence which was identified by the isolation of a methylation free CpG island from human chromosome 7 has been cloned from a human lung cDNA library. The deduced protein sequence contains 360 amino acids and has several features of a secreted protein; it is cysteine rich with a signal peptide sequence and two potential asn-linked glycosylation sites. The protein sequence shows marked similarity with human and murine int-1 and their Drosophila homolog wingless (Dint-1). This human int-1 related protein, int-1 and Dint-1 have diverse patterns of expression, but the inferred structural similarities suggest that some of the functional characteristics of these proteins may be shared.
Wainwright
B J
BJ
Department of Biochemistry, St Mary's Hospital Medical School, London, UK.
Scambler
P J
PJ
Stanier
P
P
Watson
E K
EK
Bell
G
G
Wicking
C
C
Estivill
X
X
Courtney
M
M
Boue
A
A
Pedersen
P S
PS
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002897:Chromosomes, Human, Pair 7; D004247:DNA / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics; D005796:Genes; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D008168:Lung / Q000032:analysis; D051379:Mice / Q000235:genetics; D008969:Molecular Sequence Data; D011499:Protein Processing, Post-Translational; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051153:Wnt Proteins; D051155:Wnt1 Protein; D051154:Wnt2 Protein; D029961:Zebrafish Proteins
D006133:Growth Substances; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D051155:Wnt1 Protein; D051154:Wnt2 Protein; D029961:Zebrafish Proteins; D004247:DNA