Effects of diphosphonate and x-rays on bone lesions induced in rats by prostate cancer cells.
Prostate adenocarcinoma-III (PA-III) cells deposited over the scapula of Lobund-Wistar (L-W) rats induced osteolytic and osteoplastic changes in that bone. The osteolytic process was prevented and interrupted by administrations of dichloromethylene diphosphonate (Cl2MDP); but the osteoplastic process, once initiated, continued. The latter process was interrupted by ionizing radiation. Treatments of PA-III-affected bones with Cl2MDP and x-rays immobilized both osteolytic and osteoplastic processes.
Pollard
M
M
Lobund Laboratory, University of Notre Dame, IN.
Luckert
P H
PH
Scheu
J
J
D000230:Adenocarcinoma / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D000818:Animals; D004002:Clodronic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D008297:Male; D009368:Neoplasm Transplantation; D010006:Osteoblasts / Q000473:pathology / Q000528:radiation effects; D010010:Osteoclasts / Q000187:drug effects / Q000473:pathology; D010014:Osteolysis / Q000517:prevention & control*; D010015:Osteolysis, Essential / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D011471:Prostatic Neoplasms; D051381:Rats; D011919:Rats, Inbred Strains; D012540:Scapula / Q000473:pathology; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured / Q000637:transplantation
D004164:Diphosphonates; D004002:Clodronic Acid