title: A determinant of polyomavirus virulence enhances virus growth in cells of renal origin.
abstract: We have identified a strain of polyomavirus, Py(L), which is unusual in causing acute morbidity and early death after inoculation of newborn mice. We determined that these animals died of kidney failure associated with extensive, virus-mediated destruction of renal tissue. Interestingly, the Py(L) strain infects baby mouse kidney cell cultures more efficiently than do other strains.
authors.forename: J B
authors.initials: JB
authors.lastname: Bolen
authors.forename: S E
authors.initials: SE
authors.lastname: Fisher
authors.forename: K
authors.initials: K
authors.lastname: Chowdhury
authors.forename: T C
authors.initials: TC
authors.lastname: Shan
authors.forename: J E
authors.initials: JE
authors.lastname: Williams
authors.forename: C J
authors.initials: CJ
authors.lastname: Dawe
authors.forename: M A
authors.initials: MA
authors.lastname: Israel
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D007668:Kidney / Q000254:growth & development / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D011120:Polyomavirus / Q000254:growth & development / Q000472:pathogenicity*; D014412:Tumor Virus Infections / Q000382:microbiology; D014774:Virulence