Regional infusion of fluoropyrimidines for hepatic metastases of colorectal cancer.
Recent reports on regional chemotherapy for hepatic metastases of colorectal origin are reviewed. Because of reported side effects and lack of evidence for its superiority over conventional intravenous administration, intra-arterial administration of fluoropyrimidines cannot be advised for routine use, but should be restricted to centres participating in clinical trials on this subject.
Koks
C H
CH
Department of Clinical Pharmacy, General Hospital De Tjongerschans, Heerenveen, The Netherlands.
Brouwers
J R
JR
Sleijfer
D T
DT
D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000473:pathology*; D005467:Floxuridine / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D006499:Hepatic Artery; D006801:Humans; D007260:Infusion Pumps; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D011168:Portal System; D012004:Rectal Neoplasms / Q000473:pathology*
D005467:Floxuridine; D005472:Fluorouracil