Hepatitis B surface antigen in hepatocellular carcinoma.
Hepatitis B surface antigen (HBs-Ag) was detected histologically (by victoria blue-nuclear fast red staining) in the liver in 20-40% of liver cirrhosis and/or hepatocellular carcinoma (hepatoma) cases. In hepatoma cases, HBs-Ag was usually found in non-cancerous areas of the liver. However, some HBs-Ag positive cells were also found dispersed in cancerous areas; these were regarded as HBs-Ag-infected non-cancerous hepatic cells remaining undestroyed. There were a few cases where inconsistency was found between the results of the immunofluorescence technique using anti HBs-Ag serum and victoria blue staining in detecting HBs-Ag. This phenomenon was rare in non-cancerous areas, but was relatively frequent in cancerous areas.
Tanaka
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Mori
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D006528:Carcinoma, Hepatocellular / Q000276:immunology*; D004396:Coloring Agents; D005455:Fluorescent Antibody Technique; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D008103:Liver Cirrhosis / Q000276:immunology; D008113:Liver Neoplasms / Q000276:immunology*; D009930:Organic Chemicals
D004396:Coloring Agents; D006514:Hepatitis B Surface Antigens; D009930:Organic Chemicals; C041370:victoria blue