Cervical myelography with iohexol and metrizamide. A randomized double blind clinical study.
A randomized double-blind study with iohexol and metrizamide in cervical myelography was performed in 100 patients. The concentration of the contrast medium was 240 mg I/ml. The image quality was equal with both contrast media. Forty-two per cent of the patients receiving iohexol had side effects (headache 22%, nausea 6%, vomiting 2% and mental reactions 6%), in contrast to 80 per cent of the patients receiving metrizamide (headache 56%, nausea 34%, vomiting 24% and mental reactions 26%). The majority of side effects appeared within 6 hours after injection of contrast medium. Two patients had a late onset of symptoms - one in each group. Once appearing, the side effects tended to be equally severe.
Servo
A
A
Roentgen Division, Töölö Hospital, Helsinki University Central Hospital, Finland.
Porras
M
M
Jääskinen
J
J
Virta
A
A
Laasonen
E M
EM
D000293:Adolescent; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007472:Iohexol / Q000009:adverse effects; D008297:Male; D008793:Metrizamide / Q000009:adverse effects; D008875:Middle Aged; D009192:Myelography
D007472:Iohexol; D008793:Metrizamide