Arachidonic acid, an in vivo inhibitor of carrageenin induced granulomas in the rat.
Arachidonic acid (AA) injected locally into carrageenin/sponge granulomas, but not if given orally, inhibited granuloma growth. Granuloma macrophage (M0) infiltration was inhibited, and prostaglandin E2 (PGE2) synthesis (ng/100 mg granuloma dry weight) stimulated, by AA treatment. M0 adenosine 3',5'-cyclic monophosphate (cAMP) levels and granuloma exudate volume were not affected. Granuloma M0s incubated in vitro with arachidonic acid synthesised thromboxane B2 (Txb2), 6-ketoprostaglandin F1 alpha (6-ketoPGF1 alpha), and preferentially, PGE2. The AA inhibition of granuloma growth was possibly mediated via the synthesis of PGE2.
Elliott
G R
GR
Adolfs
M J
MJ
Bonta
I L
IL
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology*; D002351:Carrageenan; D000242:Cyclic AMP / Q000378:metabolism; D015232:Dinoprostone; D004537:Eicosanoic Acids / Q000378:metabolism; D005122:Exudates and Transudates / Q000378:metabolism; D006099:Granuloma / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D008264:Macrophages / Q000187:drug effects; D008297:Male; D011458:Prostaglandins E / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013929:Thromboxane B2 / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D004537:Eicosanoic Acids; D011458:Prostaglandins E; D016718:Arachidonic Acid; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D002351:Carrageenan; D000242:Cyclic AMP; D015232:Dinoprostone