[Treatment of erythrodermic and pustulous psoriasis with a combination of methotrexate and etretinate].
We present herein our experience concerning the use of etretinate and methotrexate as concurrent therapies in three patients with severe psoriasis. On this regimen, rapid clearing of the psoriatic lesions has been achieved in all patients. The efficacy, safety, indications and dosage schedules for this combination therapy are discussed. No significant side effects have been observed in our patients. However, caution must be exercised in the use of this experimental combination regimen, which should only be used in severe psoriasis.
Allegue Rodriguez
F
F
Servicio de Dermatología, Hospital Ramón y Cajal, Madrid.
Sendagorta Gomendio
E
E
Freire Murgueytio
P
P
Moreno Izquierdo
R
R
Ledo Pozueta
A
A
D000328:Adult; D003873:Dermatitis, Exfoliative / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005050:Etretinate / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy
D005050:Etretinate; D008727:Methotrexate
Tratamiento del psoriasis eritrodérmico y pustuloso con terapéutica combinada de metotrexato y etretinato.