Adrenergic receptors on cerebral microvessels in control and parkinsonian subjects.
The binding of adrenergic ligands (3H-prazosin, 3H-clonidine, 3H-dihydroalprenolol) was studied on a preparation of cerebral microvessels in the prefrontal cortex and putamen of control and Parkinsonian subjects. The adrenergic receptor density in microvessels of control patients was less than 0.5% and 3.3% respectively of the total binding. A significant decrease in the number of alpha-1 binding sites was observed on microvessels in the putamen of patients with Parkinson's disease.
Cash
R
R
Lasbennes
F
F
Sercombe
R
R
Seylaz
J
J
Agid
Y
Y
D000368:Aged; D000526:Alprenolol / Q000031:analogs & derivatives*; D002196:Capillaries / Q000378:metabolism; D002560:Cerebrovascular Circulation; D003000:Clonidine / Q000378:metabolism*; D004082:Dihydroalprenolol / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D010300:Parkinson Disease / Q000378:metabolism*; D011224:Prazosin / Q000378:metabolism*; D011799:Quinazolines / Q000378:metabolism*; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012016:Reference Values
D011799:Quinazolines; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D000526:Alprenolol; D003000:Clonidine; D011224:Prazosin