Enprostil inhibits post-prandial gastrin release: a dose-response study.
In a double-blind placebo-controlled study in nine healthy volunteers, the effects of single doses of oral enprostil (8.75, 17.5, 35 and 70 micrograms), taken before a standard breakfast, were assessed on the post-prandial release of gastrin into the plasma. All doses of enprostil caused a significant dose-related decrease in median post-prandial plasma gastrin concentration (range from -29 to -44%). In the same subjects, two doses of 25 mg indomethacin caused a significant (38%) increase in median post-prandial plasma gastrin concentration.
Lanzon-Miller
S
S
Academic Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
Allison
M C
MC
Pounder
R E
RE
Ball
S
S
Hamilton
M R
MR
Chronos
N A
NA
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004435:Eating; D016620:Enprostil / Q000494:pharmacology*; D005755:Gastrins / Q000378:metabolism*; D006801:Humans; D008297:Male
D005755:Gastrins; D016620:Enprostil