[Decrease of erythrocyte receptors for the C3b fragment of complement in acquired immunodeficiency syndrome].
The number of C3b receptors (CR1) on erythrocytes (E) was measured, using a newly developed flow cytometry assay and a standard radioimmunoassay, in HIV-infected individuals and in a normal control population. The number of CR1/E was significantly decreased in symptomatic HIV-infected patients with ARC and acquired immunodeficiency syndrome and was normal in asymptomatic carriers of anti-HIV antibodies. Decreased numbers of CR1/E correlated with the clinical severity of the HIV-related disease. A close correlation was found between results obtained with flow cytometry and those obtained with the radioimmuno-assay. Flow cytometric assessment of CR1/E may be of interest in large scale prospective clinical studies of HIV-infected subjects.
Cohen
J H
JH
Laboratoire d'Immunologie, Hôpital R. Debré, Reims.
Autran
B
B
Jouvin
M H
MH
Aubry
J P
JP
Rozenbaum
W
W
Banchereau
J
J
Debré
P
P
Revillard
J P
JP
Kazatchkine
M
M
D000386:AIDS-Related Complex / Q000097:blood; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood*; D003179:Complement C3b / Q000032:analysis*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005434:Flow Cytometry; D006679:HIV Seropositivity / Q000097:blood; D006801:Humans; D011446:Prospective Studies; D011863:Radioimmunoassay; D011951:Receptors, Complement / Q000378:metabolism*
D011951:Receptors, Complement; D003179:Complement C3b
Diminution des récepteurs érythrocytaires pour le fragment C3b du complément dans le syndrome d'immunodéficience acquise.