Effects of iodixanol, iopentol, iohexol and metrizoate on femoral blood flow after injection into the femoral artery of the dog.
The femoral blood flow was measured before, during and three min after random injection of iodixanol, iopentol, iohexol and metrizoate into the femoral arteries of 12 beagle dogs. The doses were 0.15 and 0.30 ml/kg body weight. Concentrations were 320 mg I/ml. The maximal increases in blood flow were (median values are presented and the lower dose is given first): iodixanol 9% and 32%, iopentol 28% and 66%, iohexol 43% and 77%, and metrizoate 161% and 215%. At both doses iodixanol produced significantly smaller flow increase than any other medium. At both doses iopentol and iohexol produced significantly smaller flow increase than metrizoate (p less than 0.005). There was no significant difference between iopentol and iohexol (p greater than 0.1).
Almén
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Department of Diagnostic Radiology, Malmö Allmänna Sjukhus, University of Lund, Sweden.
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D005263:Femoral Artery / Q000502:physiology*; D007269:Injections, Intra-Arterial; D007472:Iohexol / Q000494:pharmacology; D008297:Male; D008794:Metrizoic Acid / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D014283:Triiodobenzoic Acids / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C053571:iopentol; D008794:Metrizoic Acid; C044834:iodixanol