title: Association of HLA and other genetic markers in South Indian patients with pulmonary tuberculosis.
abstract: Histocompatibility antigens (A, B & C loci) and 23 other single gene characters were studied in 204 pulmonary tuberculosis patients belonging to a single endogamous group in South India. None of the previously reported associations with HLA antigens was confirmed, nor any new one found. The blood O and Rh negative associations were also not confirmed, although a new association with the Jk blood group system appears possible. Of particular interest is the association with the phosphoglucomutase (PGM1) system, which parallels that found in a different population located some 1000 km away. Relative risks were calculated to measure the resistance of individuals with the PGM1*2+ allele.
authors.affiliation: Department of Human Genetics, University of Newcastle upon Tyne, UK.
authors.forename: S S
authors.initials: SS
authors.lastname: Papiha
authors.forename: B N
authors.initials: BN
authors.lastname: Singh
authors.forename: J S
authors.initials: JS
authors.lastname: Lanchbury
authors.forename: D F
authors.initials: DF
authors.lastname: Roberts
authors.forename: C E
authors.initials: CE
authors.lastname: Parsad
authors.forename: J
authors.initials: J
authors.lastname: Wentzel
authors.forename: K J
authors.initials: KJ
authors.lastname: Murty
mesh_terms: D001789:Blood Group Antigens / Q000235:genetics; D004912:Erythrocytes / Q000201:enzymology; D005787:Gene Frequency; D005819:Genetic Markers; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006801:Humans; D007194:India; D010641:Phenotype; D010733:Phosphoglucomutase / Q000235:genetics; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000235:genetics*
chemical_list: D001789:Blood Group Antigens; D005819:Genetic Markers; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D010733:Phosphoglucomutase