Cefodizime administration in healthy subjects: studies of natural killer cells, urinary hormones and electrolytes.
Two studies are here discussed: the first one on changes of the natural killer cell activity of PBM cells exposed in vitro to CDZ and the second one on urinary electrolytes, cortisol, aldosterone and DHEA-S circadian rhythms, evaluated in healthy subjects who received a single dose (2 g i.v.) of cefodizime (CDZ). The effect of CDZ in health includes a reduction of the circadian amplitude of natural killer cell activity. With the methods used, no difference was found between placebo and CDZ, as far as circadian rhythms of urinary electrolytes, cortisol, aldosterone and DHEA-S are concerned.
Ventura
M M
MM
Clinica Medica II-Geriatria, Facoltà di Medicina e Chirurgia, Università degli Studi di Perugia, Italy.
Romagnoli
M
M
Santucci
S
S
Sforza
C
C
Gatti
G
G
Carandente
O
O
D000276:Adjuvants, Immunologic; D000328:Adult; D000450:Aldosterone / Q000652:urine; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D002460:Cell Line; D002940:Circadian Rhythm / Q000187:drug effects*; D003602:Cytotoxicity, Immunologic; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000652:urine; D019314:Dehydroepiandrosterone Sulfate; D004573:Electrolytes / Q000652:urine*; D006728:Hormones / Q000652:urine*; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008297:Male; D012016:Reference Values
D000276:Adjuvants, Immunologic; D004573:Electrolytes; D006728:Hormones; D003687:Dehydroepiandrosterone; D000450:Aldosterone; D019314:Dehydroepiandrosterone Sulfate; D002439:Cefotaxime; D006854:Hydrocortisone; C033356:cefodizime