title: The second human calcitonin/CGRP gene is located on chromosome 11.
abstract: A second human calcitonin/calcitonin gene related peptide (hCT/CGRP) gene has been identified. This second hCT/CGRP gene has been shown to contain sequences highly homologous to exons 3, 5 (CGRP-encoding), and 6 of the first hCT/CGRP gene, but sequences closely related to exon 4 (CT-encoding) could not be demonstrated. Southern blot hybridization analysis of DNA from human-rodent somatic cell hybrids showed that the second hCT/CGRP gene is located in the q12-pter region of chromosome 11. The first hCT/CGRP gene has previously been assigned to the p13-p15 region of chromosome 11.
authors.forename: J W
authors.initials: JW
authors.lastname: Höppener
authors.forename: P H
authors.initials: PH
authors.lastname: Steenbergh
authors.forename: J
authors.initials: J
authors.lastname: Zandberg
authors.forename: A H
authors.initials: AH
authors.lastname: Geurts van Kessel
authors.forename: S B
authors.initials: SB
authors.lastname: Baylin
authors.forename: B D
authors.initials: BD
authors.lastname: Nelkin
authors.forename: H S
authors.initials: HS
authors.lastname: Jansz
authors.forename: C J
authors.initials: CJ
authors.lastname: Lips
mesh_terms: D000818:Animals; D001483:Base Sequence; D002116:Calcitonin / Q000235:genetics*; D015740:Calcitonin Gene-Related Peptide; D002460:Cell Line; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D006224:Cricetinae; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D004587:Electrophoresis, Agar Gel; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009693:Nucleic Acid Hybridization
chemical_list: D009419:Nerve Tissue Proteins; D002116:Calcitonin; D004247:DNA; D004262:DNA Restriction Enzymes; D015740:Calcitonin Gene-Related Peptide