title: Therapeutic efficacy of medicating drinking water with spectinomycin and lincomycin-spectinomycin in experimental Escherichia coli infection in poultry.
abstract: Although no microbiological activity was found in blood plasma during treatment of broilers through the drinking water with spectinomycin or lincomycin-spectinomycin, these drugs proved highly effective in treating experimentally induced colibacillosis. This efficacy may be produced by a metabolite or a degradation product of spectinomycin that reaches the infection site in the respiratory tract and interferes with adherence of bacteria.
authors.affiliation: Poultry Health Institute, Doorn, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Goren
authors.forename: W A
authors.initials: WA
authors.lastname: de Jong
authors.forename: P
authors.initials: P
authors.lastname: Doornenbal
mesh_terms: D000818:Animals; D002645:Chickens / Q000382:microbiology*; D004338:Drug Combinations; D004341:Drug Evaluation / Q000662:veterinary; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000662:veterinary*; D008034:Lincomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D011201:Poultry Diseases / Q000188:drug therapy* / Q000382:microbiology; D000198:Spectinomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D014881:Water Supply
chemical_list: D004338:Drug Combinations; D000198:Spectinomycin; D008034:Lincomycin