title: Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.
abstract: We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor alpha-subunit, a precursor processing enzyme cleavage site, then the beta-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.
authors.forename: A
authors.initials: A
authors.lastname: Ullrich
authors.forename: J R
authors.initials: JR
authors.lastname: Bell
authors.forename: E Y
authors.initials: EY
authors.lastname: Chen
authors.forename: R
authors.initials: R
authors.lastname: Herrera
authors.forename: L M
authors.initials: LM
authors.lastname: Petruzzelli
authors.forename: T J
authors.initials: TJ
authors.lastname: Dull
authors.forename: A
authors.initials: A
authors.lastname: Gray
authors.forename: L
authors.initials: L
authors.lastname: Coussens
authors.forename: Y C
authors.initials: YC
authors.lastname: Liao
authors.forename: M
authors.initials: M
authors.lastname: Tsubokawa
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D066246:ErbB Receptors; D005796:Genes; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D008970:Molecular Weight; D009857:Oncogenes; D011487:Protein Conformation; D011494:Protein Kinases / Q000235:genetics*; D011505:Protein-Tyrosine Kinases; D012333:RNA, Messenger / Q000235:genetics; D011972:Receptor, Insulin / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics
chemical_list: D008565:Membrane Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D004247:DNA; D011494:Protein Kinases; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases; D011972:Receptor, Insulin