title: Southern analysis of DNA polymorphism among Dw subtypes of DR4.
abstract: DNA from individuals of four Dw subtypes of DR4 (Dw4, Dw10, Dw14, Dw15) were studied using Southern blotting to determine if subtype-specific DR beta or DQ beta restriction fragment polymorphism could be found. Although very little polymorphism was found among ten DR4 homozygous individuals (4 Dw4, 2 Dw10, 3 Dw14, 1 Dw15) using a Dr beta or a DQ beta probe, restriction fragment polymorphism was easily detected between different DR types (DR1-DRw8). The possible evolutionary significance of the lack of Dw-associated polymorphism relative to DR-associated polymorphism is discussed.
authors.forename: J A
authors.initials: JA
authors.lastname: Nicklas
authors.forename: H J
authors.initials: HJ
authors.lastname: Noreen
authors.forename: M
authors.initials: M
authors.lastname: Segall
authors.forename: F H
authors.initials: FH
authors.lastname: Bach
mesh_terms: D004262:DNA Restriction Enzymes; D005796:Genes; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000145:classification / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D004262:DNA Restriction Enzymes