[The combined effect of an ethinylestradiol/desogestrel contraceptive combination on blood lipids and parameters of liver function and coagulation].
The present study aims to evaluate the contraceptive efficacy of the new combination ethinylestradiol (30 micrograms)/desogestrel (150 micrograms) and, moreover, to demonstrate its low side effects compared to the symptoms present in the pretreatment cycles. In particular the authors took into consideration the changes in serum lipids, and hepatic and coagulation function parameters induced by pill, in 40 healthy women. An interesting result is that the estrogen induced increase of cholesterol-HDL is not antagonized by the desogestrel that has a slight affinity to androgenic receptors and SHBG. This is obviously of great importance in the prevention of atheromatous lesions.
Massafra
C
C
Institut de Clinique Obstétricale et Gynécologique de l'Université de Sienne, Italie.
Capitani
S
S
Bernabei
A
A
Scillone
L
L
D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology*; D017135:Desogestrel; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D009652:Norpregnenes / Q000494:pharmacology*; D045167:Progesterone Congeners / Q000494:pharmacology*
D003277:Contraceptives, Oral, Combined; D008055:Lipids; D009652:Norpregnenes; D045167:Progesterone Congeners; D004997:Ethinyl Estradiol; D017135:Desogestrel
Effets combinés d'une association contraceptive éthinylestradiol/désogestrel sur les lipides sériques et les paramètres des fonctions hépatiques et de la coagulation.