Effect of subchronic dieldrin treatment on calmodulin-regulated Ca2+ pump activity in rat brain.
Calmodulin-dependent (CaM-dependent) and nondependent Ca2+ pump activity was determined in the brain P2 fraction of Sprague-Dawley rats treated in vivo with 10 ppm dieldrin for 60 d. After 40 d of dieldrin intoxication, daily food consumption and body weight gain were found to be affected. Dieldrin inhibited both CaM-dependent and -independent Ca2+-ATPase activity and the enzyme activity decreased to 36% (CaM-dependent)--and 18% (basal) respectively after 60 d of intoxication. Reduction in brain CaM levels and a subsequent inhibition of Ca2+-ATPase activity suggests that chronic intoxication of dieldrin at very low doses alters calmodulin and its regulation of Ca2+-ATPase activity.
Mehrotra
B D
BD
Department of Chemistry, Tougaloo College, Mississippi.
Ravichandra Reddy
S
S
Desaiah
D
D
D000818:Animals; D001921:Brain / Q000201:enzymology*; D000252:Calcium-Transporting ATPases / Q000032:analysis / Q000378:metabolism*; D002147:Calmodulin / Q000032:analysis / Q000378:metabolism*; D004026:Dieldrin / Q000633:toxicity*; D004435:Eating / Q000187:drug effects; D006128:Growth / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002147:Calmodulin; D000252:Calcium-Transporting ATPases; D004026:Dieldrin