title: Surface antigens of theophylline-resistant and theophylline-sensitive human E rosette-forming T lymphocytes.
abstract: Theophylline-resistant (TER) and theophylline-sensitive (TES) subsets of E rosette-forming T cells were analysed for surface antigens detected by monoclonal antibodies Leu-2, Leu-15, Leu-3, and Leu-8. Two-colour analysis was performed by laser flow cytometry. About 30% of TER cells was classified as Leu-2+, 15- precursor cytotoxic T lymphocytes and about 50% as 3+,8+ (T inducers). TES fraction was deficient in cytotoxic 2+,15- cells and contained lymphocytes belonging to suppressor circuit. Leu-3+,8- (helpers and suppressor-amplifiers) were present in both fractions.
authors.affiliation: Institute of Pediatrics, Warsaw Medical School.
authors.forename: E
authors.initials: E
authors.lastname: Skopinska-Rózewska
authors.forename: R B
authors.initials: RB
authors.lastname: Ettenger
authors.forename: S
authors.initials: S
authors.lastname: Plaeger-Marshall
authors.forename: M
authors.initials: M
authors.lastname: Sieniawska
authors.forename: R N
authors.initials: RN
authors.lastname: Fine
mesh_terms: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D004351:Drug Resistance; D006801:Humans; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D013806:Theophylline / Q000494:pharmacology*
chemical_list: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D013806:Theophylline