Granulocyte activating factor released from Propionibacterium acnes. A possible mediator of inflammation in acne vulgaris.
Incubation of Propionibacterium acnes but not of Propionibacterium granulosum or Propionibacterium avidum (for 30 min at 37 degrees C in physiological saline) released a soluble factor that produced enhanced chemiluminescence response of human granulocytes as well as increased chemotactic motility of these cells. Sephadex G-25 filtration of the granulocyte activating factor (GAF) revealed its low molecular weight and apparent peptide character. Thus, GAF may be a stimulus for inflammation in acne vulgaris since low molecular weight chemotactic factors can be expected to penetrate follicular walls.
Pulverer
G
G
Hygiene-Institut der Universität zu Köln.
Roszkowski
W
W
Beuth
H J
HJ
Ko
H L
HL
Quie
P
P
D000152:Acne Vulgaris / Q000209:etiology* / Q000473:pathology; D002634:Chemotaxis, Leukocyte; D002850:Chromatography, Gel; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007249:Inflammation; D007700:Kinetics; D008163:Luminescent Measurements; D008970:Molecular Weight; D010455:Peptides / Q000032:analysis / Q000276:immunology* / Q000378:metabolism; D011425:Propionibacterium acnes / Q000276:immunology*
D010455:Peptides