title: Light evoked release of acetylcholine in response to a single flash: cholinergic amacrine cells receive ON and OFF input.
abstract: By pharmacologically blocking the inhibitory inputs to the cholinergic amacrine cells of the rabbit retina, we have been able to detect the light-evoked release of ACh in response to a single flash. Under these conditions ACh is released equally at light ON and light OFF. This implies that: the cholinergic amacrine cells receive ON and OFF input; they respond to light with depolarizing transients; and the inputs to this system have a basic symmetry.
authors.forename: S C
authors.initials: SC
authors.lastname: Massey
authors.forename: D A
authors.initials: DA
authors.lastname: Redburn
mesh_terms: D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002799:Cholinergic Fibers / Q000502:physiology; D009433:Neural Inhibition; D009474:Neurons / Q000502:physiology; D010852:Picrotoxin / Q000494:pharmacology; D011817:Rabbits; D012160:Retina / Q000166:cytology*; D009435:Synaptic Transmission; D014785:Vision, Ocular / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D000109:Acetylcholine; D001285:Atropine; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid