[Alteration of blood coagulation and fibrinolysis after transcatheter arterial embolization of hepatocellular carcinomas].
Alteration in blood coagulation and fibrinolysis were observed serially after TAE 37 times by measuring PT, APTT, FDP, fibrinogen, AT III, plasminogen, and alpha 2-macroglobulin. Immediately after TAE, PT and APTT were prolonged, Fbg AT III, alpha 2-M, and platelets decreased, and FDP increased. These changes within 24 hours suggested that coagulation activities were accelerated, and fibrinolysis followed. Within four weeks after TAE, PT and APTT became most prolonged one to three days after, while AT III, Plg, and alpha 2-M became lowest on the third to seventh days. It is suggested that these decrease were mainly due to suppressed production resulting from damage of the residual liver.
Suyama
Y
Y
Iwai
M
M
Fujii
H
H
Miyoshi
M
M
D000970:Antineoplastic Agents / Q000008:administration & dosage; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000628:therapy; D004317:Doxorubicin / Q000008:administration & dosage; D004621:Embolization, Therapeutic / Q000379:methods; D005342:Fibrinolysis; D005781:Gelatin Sponge, Absorbable; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000628:therapy; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D013997:Time Factors
D000970:Antineoplastic Agents; D001779:Blood Coagulation Factors; D008937:Mitomycins; D016685:Mitomycin; D004317:Doxorubicin