Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells.
The growth factor requirements of cloned lines representing two major subsets of CD4+ T cells were examined. The helper subset, which produces IL-4 as its autocrine growth factor, proliferates in response to IL-2 or to IL-4 in the presence of IL-1. The inflammatory subset, which produces IL-2 as its autocrine growth factor, proliferates in response to IL-2 and, in the presence of limiting amounts of IL-2, shows increased proliferation in the presence of IL-4. The inflammatory subset does not proliferate in response to IL-1 plus IL-4. This ability to respond to the combination of IL-1 plus IL-4 correlates with the presence of IL-1R on the cloned lines tested. These data suggest that IL-1 may play a controlling role in the clonal expansion of CD4+ T cells of different functional types. This, in turn, suggests means by which the immune response could be directed into humoral or cell-mediated responses.
Greenbaum
L A
LA
Department of Pathology, Yale University School of Medicine, New Haven, CT 06510.
Horowitz
J B
JB
Woods
A
A
Pasqualini
T
T
Reich
E P
EP
Bottomly
K
K
D000818:Animals; D000911:Antibodies, Monoclonal / Q000502:physiology; D000945:Antigens, Differentiation, T-Lymphocyte; D002455:Cell Division / Q000187:drug effects; D002999:Clone Cells / Q000378:metabolism / Q000473:pathology; D007166:Immunosuppressive Agents / Q000502:physiology; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D007375:Interleukin-1 / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D015847:Interleukin-4; D007378:Interleukins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010641:Phenotype; D011971:Receptors, Immunologic / Q000032:analysis; D017472:Receptors, Interleukin-1; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D007166:Immunosuppressive Agents; D007375:Interleukin-1; D007378:Interleukins; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1; D015847:Interleukin-4