[Effect of total ischemia and 3',5'-cAMP on the activity of the thermostable cytoplasmic inhibitor of Ca2+ ion transport in rat heart mitochondria].
Activity of cytoplasmic inhibitor of Ca2+ transport in rat heart mitochondria was studied after total ischemia and incubation of heart homogenates with cAMP. Distinct inactivation of the inhibitor occurred under these conditions. The decrease of the inhibitor activity in ischemic myocardium appears to serve as a compensatory mechanism: 1. pyruvate dehydrogenase and the enzymes of tricarboxylic acid cycle were activated due to increase in Ca2+ concentration in mitochondria, 2. as a result of Ca2+ accumulation in mitochondria the elevated concentration of Ca2+ was decreased in myoplasm, which developed after impairment of plasmatic membranes and of sarcoplasmic reticulum membranes.
Turakulov
Ia Kh
IaKh
Luchenko
M B
MB
Gaĭnutdinov
M Kh
MKh
Abidov
A A
AA
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000037:antagonists & inhibitors*; D003327:Coronary Disease / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D006358:Hot Temperature; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D051381:Rats
D002135:Calcium-Binding Proteins; D000242:Cyclic AMP; D002118:Calcium
Vliianie total'noĭ ishemii i ts-3',5'-AMF na aktivnost' termostabil'nogo tsitoplazmaticheskogo ingibitora transporta ionov Ca2+ v mitokhondrii serdtsa krysy.