title: [Influence of pregnancy on the development of Hodgkin's disease].
abstract: This retrospective study concerns 13 patients in whom Hodgkin's disease was diagnosed during pregnancy or immediately after delivery (group I) and 12 patients with Hodgkin's disease who had one or several pregnancies while under treatment (group II). In group I, Hodgkin's disease was diagnosed in early pregnancy in 4 patients who all had therapeutic abortion: 3 remain in prolonged complete remission and 1 had a late relapse; 9 cases were diagnosed in late pregnancy or after delivery: 3 were treatment failures, 2 had a relapse and 4 remain in complete remission. In group II patients, 3 pregnancies occurred during initial chemotherapy and were interrupted; 5 pregnancies occurred during subsequent radiotherapy or (for earlier patients) maintenance chemotherapy, and 4 of them were interrupted; 9 pregnancies occurred within 2 years of completing treatment, and 7 after 2 years. Of the 12 patients in group II, only 2 had a relapse whereas 10 remain in complete remission. Although they should be interpreted with caution, these data suggest that Hodgkin's disease diagnosed in late pregnancy or after delivery might be more active, and they justify therapeutic abortion when diagnosis is made in early pregnancy. They do not indicate a high risk of relapse in treated Hodgkin's disease patients during a subsequent pregnancy, even if it occurs shortly after treatment.
authors.affiliation: Service des Maladies du Sang, Hôpital Claude Huriez, Lille.
authors.forename: J P
authors.initials: JP
authors.lastname: Jouet
authors.forename: B
authors.initials: B
authors.lastname: Buchet-Bouverne
authors.forename: P
authors.initials: P
authors.lastname: Fenaux
authors.forename: J P
authors.initials: JP
authors.lastname: Pollet
authors.forename: M
authors.initials: M
authors.lastname: Simon
authors.forename: M P
authors.initials: MP
authors.lastname: Walter
authors.forename: J L
authors.initials: JL
authors.lastname: Leroy
authors.forename: F
authors.initials: F
authors.lastname: Puech
authors.forename: M
authors.initials: M
authors.lastname: Delecour
authors.forename: F
authors.initials: F
authors.lastname: Bauters
mesh_terms: D000032:Abortion, Therapeutic; D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D005298:Fertility; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D009367:Neoplasm Staging; D049590:Postpartum Period; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D012189:Retrospective Studies; D013997:Time Factors
vernacular_title: Influence de la grossesse sur l'évolutivité de la maladie de Hodgkin?