Glucosteroid (GS)-dependent immunomodulation of immunoglobulin biosynthesis in vitro. II. Effect of GS on mitogen- and alloantigen-induced Ig synthesis.
GS cause an enhancement of T cell regulated Ig synthesis in vitro, while direct B cell response is little affected. The action of GS depends upon the timing of their addition in vitro. Early administration of GS produces stimulation, while late may cause inhibition of Ig synthesis.
Korczak-Kowalska
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Department of Experimental Immunosuppression, Medical Academy, Warsaw.
Górski
A
A
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000502:physiology*; D002478:Cells, Cultured; D004306:Dose-Response Relationship, Immunologic; D006462:Hemolytic Plaque Technique; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis*; D007519:Isoantigens; D008198:Lymph Nodes / Q000166:cytology; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D011043:Pokeweed Mitogens; D011239:Prednisolone / Q000494:pharmacology / Q000502:physiology*; D013154:Spleen / Q000166:cytology
D000276:Adjuvants, Immunologic; D007136:Immunoglobulins; D007519:Isoantigens; D011043:Pokeweed Mitogens; D011239:Prednisolone