title: Idiopathic slow-transit constipation: whole gut transit times, measured by a new simplified method, are not shortened by opioid antagonists.
abstract: A simplified method for measuring mean whole gut transit time has been validated which avoids stool collection and is suitable for out-patients. Radio-opaque markers are swallowed daily for 14 days and the mean whole gut transit time is derived directly from an abdominal X-ray. Using this new technique, neither nalmefene (in a double-blind study of six patients) nor naloxone (in an open study of four patients) shortened mean whole gut transit time in idiopathic slow-transit constipation.
authors.affiliation: Department of Gastroenterology, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: K J
authors.initials: KJ
authors.lastname: Fotherby
authors.forename: J O
authors.initials: JO
authors.lastname: Hunter
mesh_terms: D000328:Adult; D003248:Constipation / Q000503:physiopathology*; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009292:Narcotic Antagonists / Q000494:pharmacology*; D011860:Radiography, Abdominal
chemical_list: D009292:Narcotic Antagonists