[Adrenergic mechanisms regulating coronary blood outflow into the left and right sections of the heart].
The alteration of veno-luminal drainage into the left heart chambers and of coronary drainage into the right heart chambers during adrenaline infusion were studied in isolated perfused at constant pressure cat hearts. During adrenaline infusion the coronary resistance was reduced, the coronary drainage into right chambers increased due to beta-adrenergic dilation mechanisms, and the luminal drainage into left chambers did not alter due to alpha-adrenergic constriction mechanisms. Thus, adrenergic regulatory mechanisms prevent an enlargement of veno-luminal drainage into the arterial heart chambers. Reactions of the large coronary arteries seem to determine the alterations of luminal drainage into left chambers, whereas reactions of small coronary arteries determine alterations of coronary drainage into right chambers during the adrenaline infusion.
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D000818:Animals; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D010646:Phentolamine / Q000494:pharmacology; D011412:Propanolamines / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D012212:Rheology; D014655:Vascular Resistance / Q000187:drug effects
D011412:Propanolamines; D011941:Receptors, Adrenergic; C011550:talinolol; D011433:Propranolol; D004837:Epinephrine; D010646:Phentolamine
Adrenergicheskie mekhanizmy reguliatsii ottoka koronarnoĭ krovi v levye i pravye otdely serdtsa.