title: Abnormal scleral findings in uveal effusion syndrome.
abstract: We successfully treated a patient with uveal effusion syndrome and abnormal sclera with a partial-thickness sclerectomy. Part of the sclera was immediately cultured, and the excised sclera and the cultured cells were examined by electron microscopy. The sclera demonstrated increased glycosaminoglycan-like deposits between the scleral fibers. The cultured scleral cells showed large intracellular glycogen-like deposits, which were not seen in cells cultured from two control scleras. These findings may be the result of a metabolic defect, which causes a thick, impermeable sclera in some cases of uveal effusion.
authors.affiliation: Retina Service, Massachusetts Eye and Ear Infirmary, Boston 02114.
authors.forename: R C
authors.initials: RC
authors.lastname: Ward
authors.forename: E S
authors.initials: ES
authors.lastname: Gragoudas
authors.forename: D M
authors.initials: DM
authors.lastname: Pon
authors.forename: D M
authors.initials: DM
authors.lastname: Albert
mesh_terms: D001826:Body Fluids / Q000378:metabolism; D002478:Cells, Cultured; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005260:Female; D005451:Fluorescein Angiography; D006003:Glycogen / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D012590:Sclera / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D013577:Syndrome; D014463:Ultrasonography; D014603:Uveal Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
chemical_list: D006025:Glycosaminoglycans; D006003:Glycogen