[A member of the SRC gene family, the c-erbB-1 gene, is closely related to the EGF receptor gene].
An avian erythroblastosis virus, AEV-H, induces both erythroblastosis and sarcomas in susceptible chickens. Since AEV-H carries the v-erbB as a sole oncogene, the erbB gene was suggested to be responsible for the induction of these tumors. Analysis of the amino acid sequence predicted from the nucleotide sequence of the v-erbB gene revealed that the gene product has a domain characteristic for tyrosine kinase. Recently in has been suggested has the v-erbB protein is a part of the chicken EGF (epidermal growth factor) receptor. Using antibody against either v-erbB protein or EGF receptor, we also demonstrated close similarity between the two proteins. Further studies on human genomic DNA revealed that the c-erbB-1 gene, a proto-oncogene of the v-erbB gene, is the EGF receptor gene. We were also able to identify the c-erbB-2 gene that seems to code for a EGF receptor-like protein with a domain for tyrosine kinase. Finally, we would like to show that cell lines established from human squamous cell carcinom are frequently associated with amplification of the c-erbB-1/EGF receptor gene.
Yamamoto
T
T
Kawai
S
S
Toyoshima
K
K
D001355:Alpharetrovirus / Q000235:genetics*; D000595:Amino Acid Sequence; D001354:Avian Leukosis Virus / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000032:analysis; D002460:Cell Line; D066246:ErbB Receptors; D005260:Female; D005814:Genes, Viral; D006801:Humans; D009857:Oncogenes; D000090063:Proto-Oncogene Mas; D011956:Receptors, Cell Surface / Q000032:analysis / Q000235:genetics*; D014846:Vulvar Neoplasms / Q000032:analysis
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011956:Receptors, Cell Surface; D066246:ErbB Receptors