Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase.
We purified CALLA from human kidney and isolated a cDNA clone reactive with two oligonucleotide probes corresponding to two distinct peptides. The amino acid sequence translated from the CALLA cDNA revealed 100% identity with that of human neutral endopeptidase (NEP, enkephalinase). The distribution of CALLA antigen and NEP in normal tissues are similar.
Letarte
M
M
Department of Immunology, Hospital for Sick Children, Toronto, Canada.
Vera
S
S
Tran
R
R
Addis
J B
JB
Onizuka
R J
RJ
Quackenbush
E J
EJ
Jongeneel
C V
CV
McInnes
R R
RR
D000595:Amino Acid Sequence; D000943:Antigens, Differentiation / Q000235:genetics*; D000951:Antigens, Neoplasm / Q000235:genetics*; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology; D001483:Base Sequence; D015152:Blotting, Northern; D002846:Chromatography, Affinity; D003001:Cloning, Molecular; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D007672:Kidney Cortex / Q000201:enzymology / Q000276:immunology; D008969:Molecular Sequence Data; D015260:Neprilysin / Q000235:genetics* / Q000276:immunology; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000276:immunology*; D012334:RNA, Neoplasm / Q000235:genetics
D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D015342:DNA Probes; D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D015260:Neprilysin