title: Structure of a human common cold virus and functional relationship to other picornaviruses.
abstract: We report the first atomic resolution structure of an animal virus, human rhinovirus 14. It is strikingly similar to known icosahedral plant RNA viruses. Four neutralizing immunogenic regions have been identified. These, and corresponding antigenic sequences of polio and foot-and-mouth disease viruses, reside on external protrusions. A large cleft on each icosahedral face is probably the host cell receptor binding site.
authors.forename: M G
authors.initials: MG
authors.lastname: Rossmann
authors.forename: E
authors.initials: E
authors.lastname: Arnold
authors.forename: J W
authors.initials: JW
authors.lastname: Erickson
authors.forename: E A
authors.initials: EA
authors.lastname: Frankenberger
authors.forename: J P
authors.initials: JP
authors.lastname: Griffith
authors.forename: H J
authors.initials: HJ
authors.lastname: Hecht
authors.forename: J E
authors.initials: JE
authors.lastname: Johnson
authors.forename: G
authors.initials: G
authors.lastname: Kamer
authors.forename: M
authors.initials: M
authors.lastname: Luo
authors.forename: A G
authors.initials: AG
authors.lastname: Mosser
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D005075:Biological Evolution; D002213:Capsid / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D003461:Crystallography; D008958:Models, Molecular; D010849:Picornaviridae / Q000648:ultrastructure; D011991:Receptors, Virus / Q000032:analysis; D012229:Rhinovirus / Q000648:ultrastructure*; D012703:Serotyping; D014764:Viral Proteins / Q000032:analysis; D015678:Viral Structural Proteins
chemical_list: D000596:Amino Acids; D000956:Antigens, Viral; D011991:Receptors, Virus; D014764:Viral Proteins; D015678:Viral Structural Proteins