Twenty-eight week toxicity study of perlite powder in mice.
Groups of 21 male and 21 female mice were given diets containing 20%, 10%, 1% or 0% (control) perlite for 28 weeks. Appearance, behavior, mortality, and food consumption of mice of treated groups were not affected during the experimental period. Males of the 20% and 10% groups did experience slightly reduced growth rate. No significant drug-related changes were found in urinalysis, hematology, serum chemistry, and organ weight. No differences were found between control and treated groups in autopsy and histopathological findings. Therefore, the maximum no-effect level is considered to be 1% in the diet which developed no toxic changes in any items examined in mice treated orally with perlite for 28 weeks.
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D000284:Administration, Oral; D000537:Aluminum Oxide; D000818:Animals; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006403:Hematologic Tests; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011208:Powders; D012822:Silicon Dioxide / Q000633:toxicity*; D013154:Spleen / Q000473:pathology; D013997:Time Factors; D014556:Urine / Q000032:analysis
D011208:Powders; C003076:Perlite; D012822:Silicon Dioxide; D000537:Aluminum Oxide