Preferential inhibition of plasmid replication in vivo by altered DNA gyrase activity in Escherichia coli.
The thermosensitive growth phenotype exerted by runaway-mutant plasmids was suppressed by sublethal doses of the DNA gyrase inhibitors novobiocin or nalidixic acid, although the latter drug was less efficient. A novobiocin-resistant gyrB mutant Escherichia coli strain prevented expression of the runaway phenotype at 37 to 42 degrees C in the absence of any drug.
Uhlin
B E
BE
Nordström
K
K
D004261:DNA Replication / Q000187:drug effects; D004250:DNA Topoisomerases, Type II / Q000235:genetics*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D006358:Hot Temperature; D009154:Mutation; D009675:Novobiocin / Q000494:pharmacology; D010957:Plasmids; D059005:Topoisomerase II Inhibitors
D059005:Topoisomerase II Inhibitors; D009675:Novobiocin; D004250:DNA Topoisomerases, Type II