title: Indications of a differentiated regulation of sound transmission by the middle ear muscles of the rat.
abstract: Measurement of the middle ear muscle reflex is an important tool in audiologic examination; however, the precise function of the tensor tympani and stapedius muscle is not fully understood. The function of the middle ear muscles in speech discrimination and noise-induced hearing loss is the main object of our study. Morphologic and enzyme-histochemical properties of the middle ear muscles of the rat indicate a complex, fine-tuned function of the middle ear muscles. Both middle ear muscles are merely composed of relatively small fast-twitch fibers. Almost all fibers possess an enzymatic profile that allows aerobic as well as anaerobic metabolism. The innervation of the muscles is extensive, and motor end plates are well developed. In a parallel study, middle ear muscle contraction (to be analyzed by electromyography) will be correlated with a change of the sound transmission characteristics of the middle ear (measured by the electrocochlear and brainstem auditory evoked responses). Preliminary results of the electrophysiologic measurements (electrocochleogram and brainstem auditory evoked response) are presented.
authors.affiliation: Department of Otorhinolaryngology, Academic Hospital at the University of Limburg, Maastricht, The Netherlands.
authors.forename: F I
authors.initials: FI
authors.lastname: de Jong
authors.forename: H
authors.initials: H
authors.lastname: Kingma
authors.forename: P
authors.initials: P
authors.lastname: Wirtz
authors.forename: H
authors.initials: H
authors.lastname: vd Berge
authors.forename: E H
authors.initials: EH
authors.lastname: Marres
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001300:Audiometry, Evoked Response; D066298:In Vitro Techniques; D008297:Male; D008854:Microscopy, Electron; D009132:Muscles / Q000502:physiology*; D051381:Rats; D013198:Stapedius / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D013719:Tensor Tympani / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D014432:Tympanic Membrane / Q000502:physiology*
chemical_list: D000110:Acetylcholinesterase; D000251:Adenosine Triphosphatases