The use of collagenase in the treatment of Peyronie's disease.
Purified clostridial collagenase was administered intralesionally in 31 men with Peyronie's disease. Within 4 weeks of treatment 20 patients showed an objective improvement. Pain was eliminated in 13 of 14 patients with this complaint at presentation within the same 4-week period. The ability to have intercourse was restored in 3 of 4 patients with this problem. Except for a small corporeal rupture at the site of injection in 1 patient, no significant untoward effects were noted. During the mean 9.8-month followup 1 recurrence of bending was noted.
Gelbard
M K
MK
Lindner
A
A
Kaufman
J J
JJ
D000328:Adult; D000368:Aged; D000629:Aminopropionitrile / Q000031:analogs & derivatives / Q000627:therapeutic use; D004341:Drug Evaluation; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D003012:Microbial Collagenase / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010411:Penile Induration / Q000503:physiopathology / Q000628:therapy*; D010413:Penis / Q000503:physiopathology; D012008:Recurrence; D013997:Time Factors
C027243:beta-aminopropionitrile fumarate; D000629:Aminopropionitrile; D003012:Microbial Collagenase