Systemic lipopolysaccharide and pokeweed mitogen increase quinolinic acid content of mouse cerebral cortex.
The effects of lipopolysaccharide and pokeweed mitogen on brain L-tryptophan and quinolinic acid (QUIN) concentrations were investigated in C57BL/6NCR mice. Twenty-four hours after an intraperitoneal injection of lipopolysaccharide (5 micrograms from Salmonella abortus equii) or pokeweed mitogen (500 micrograms), cortical QUIN concentrations were increased by 81 +/- 6% and 182 +/- 15%, respectively. Plasma QUIN was increased 175 +/- 7% of control in pokeweed-mitogen treated mice only. Brain L-tryptophan concentrations were increased, whereas plasma L-tryptophan concentrations were decreased. The consequences of increased QUIN concentrations during endotoxin and mitogen exposure remain to be determined.
Heyes
M P
MP
Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, MD 20892.
Kim
P
P
Markey
S P
SP
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011043:Pokeweed Mitogens / Q000494:pharmacology*; D011725:Pyridines / Q000378:metabolism*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000097:blood / Q000378:metabolism*; D012475:Salmonella; D014364:Tryptophan / Q000097:blood / Q000378:metabolism
D008070:Lipopolysaccharides; D011043:Pokeweed Mitogens; D011725:Pyridines; D011805:Quinolinic Acids; D014364:Tryptophan; D017378:Quinolinic Acid