The alpha-spectrin gene is on chromosome 1 in mouse and man.
By using alpha-spectrin cDNA clones of murine and human origin and somatic cell hybrids segregating either mouse or human chromosomes, the gene for alpha-spectrin has been mapped to chromosome 1 in both species. This assignment of the mouse alpha-spectrin gene to mouse chromosome 1 by DNA hybridization strengthens the previous identification of the alpha-spectrin locus in mouse with the sph locus, which previously was mapped by linkage analysis to mouse chromosome 1, distal to the Pep-3 locus. By in situ hybridization to human metaphase chromosomes, the human alpha-spectrin gene has been localized to 1q22-1q25; interestingly, the locus for a non-Rh-linked form of elliptocytosis has been provisionally mapped to band 1q2 by family linkage studies.
Huebner
K
K
Palumbo
A P
AP
Isobe
M
M
Kozak
C A
CA
Monaco
S
S
Rovera
G
G
Croce
C M
CM
Curtis
P J
PJ
D000818:Animals; D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3; D006224:Cricetinae; D003412:Cricetulus; D004262:DNA Restriction Enzymes / Q000378:metabolism; D015247:Deoxyribonuclease HindIII; D006801:Humans; D007621:Karyotyping; D051379:Mice; D009693:Nucleic Acid Hybridization; D013049:Spectrin / Q000235:genetics*
D013049:Spectrin; D004262:DNA Restriction Enzymes; D015247:Deoxyribonuclease HindIII