title: [Intermediate-term trial treatment of arrhythmia in hypertrophic myocardiopathy with sotalol].
abstract: Unlike amiodarone, beta-blockers have proved ineffective in the treatment of severe ventricular rhythm disorders encountered in hypertrophic myocardiopathy. We tried to evaluate the efficacy of sotalol, a betablocker with anti-arhythmic properties, like amiodarone, on the supraventricular and ventricular rhythm disorders of this disease. 13 patients (6 men and 7 women, mean age 53.5 +/- 26.5 years) were evaluated with a 48 hours electrocardiographic recording, before and 8 and 120 days after a sotalol treatment at a mean dose of 290 mg/day (160 to 640 mg). The diagnosis of hypertrophic myocardiopathy was established on standard clinical, phonomecanographic (13 cases), sonocardiographic (13 cases) and haemodynamic (9 cases) criteria. Five patients presented bursts of supraventricular tachycardia on DO. Their number decreased to 4 on D8 and to 3 to D120. Six patients presented Lown's class III or IV ventricular rhythm disorders on DO. Their number went from 2 on D8 to 4 on D120. Therefore, in this short series, sotalol has shown a non-negligible efficacy on the rhythm disorders encountered in hypertrophic myocardiopathy.
authors.affiliation: Service de Cardiologie, Hôpital de Bicêtre, Le Kremlin-Bicêtre.
authors.forename: C
authors.initials: C
authors.lastname: Fournier
authors.forename: C
authors.initials: C
authors.lastname: Bourmayan
authors.forename: M
authors.initials: M
authors.lastname: Cadillac
authors.forename: J
authors.initials: J
authors.lastname: Dinanian
authors.forename: M
authors.initials: M
authors.lastname: Blondeau
authors.forename: J
authors.initials: J
authors.lastname: Gay
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D006332:Cardiomegaly / Q000150:complications*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013015:Sotalol / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D013015:Sotalol
vernacular_title: Essai de traitement à moyen terme des troubles du rythme de la myocardiopathie hypertrophique par le sotalol.