Biological alterations in the primary affective disorders and other tricyclic-responsive disorders.
Noradrenergic function was studied in patients with primary affective disorder and other tricyclic-responsive disorders including obsessive-compulsive disorder, anorexia nervosa and panic attack/agoraphobia in medication-free states. Pre-synaptic noradrenergic activity was assessed by assaying plasma concentrations of norepinephrine (NE) and its metabolite 3-methoxy,4-hydroxyphenylglycol (MHPG). Noradrenergic receptor responsiveness was evaluated by measuring plasma growth hormone (GH), MHPG, and NE responses to clonidine. Binding of tritiated dihydroergocriptine (3H-DHE) and biochemical responsiveness of alpha 2-adrenergic receptors were measured in platelet preparations. These studies suggest that noradrenergic activity may be altered in several tricyclic-responsive disorders and are consistent with the possibility that tricyclic antidepressants may serve to stabilize a dysregulated noradrenergic system in patients from several diagnostic categories.
Siever
L J
LJ
Uhde
T W
TW
Insel
T R
TR
Kaye
W H
WH
Jimerson
D C
DC
Lake
C R
CR
Kafka
M
M
Targum
S
S
Murphy
D L
DL
D000328:Adult; D000379:Agoraphobia / Q000503:physiopathology; D000856:Anorexia Nervosa / Q000503:physiopathology; D003000:Clonidine / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology*; D004088:Dihydroergotoxine / Q000378:metabolism; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D001523:Mental Disorders / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology; D010200:Panic / Q000502:physiology; D011941:Receptors, Adrenergic / Q000502:physiology*; D014316:Tritium
D011941:Receptors, Adrenergic; D014316:Tritium; D004088:Dihydroergotoxine; D008734:Methoxyhydroxyphenylglycol; D013006:Growth Hormone; D000242:Cyclic AMP; D003000:Clonidine; D009638:Norepinephrine