title: Expression of Fc gamma receptor-mediated phagocytosis by airway intra-luminal macrophages.
abstract: Macrophages in the conducting airways of the lower respiratory tract constitute an anatomically defineable subpopulation of pulmonary macrophages. Little information regarding the functional characteristics of the airway intra-luminal macrophages (AI-LM) is currently available. In this study, the AI-LM resident in the trachea and mainstem bronchi of the rat were harvested by an airway lavage technique and the ability of the AI-LM to phagocytize by Fc gamma-receptors was evaluated relative to the phagocytic activities of alveolar macrophages (AM) obtained by bronchoalveolar lavage. More than 60% of the AI-LM phagocytized sheep erythrocytes opsonized with IgG (SRBC-IgG) and the distributions of the engulfed SRBC-IgG in the phagocytic AI-LM were virtually identical to those in AM. The AI-LM may represent AM that have been translocated from the alveolar space compartment to the conducting airways; it remains possible, however, that at least some of the AI-LM may have an airway origin. Regardless, the results of our phagocytic studies suggest AI-LM may functionally provide a protective phagocytic role in the conducting airways.
authors.affiliation: Pulmonary Biology - Toxicology Section, Los Alamos National Laboratory, New Mexico 87545.
authors.forename: B E
authors.initials: BE
authors.lastname: Lehnert
authors.forename: C
authors.initials: C
authors.lastname: Sanz-Rodriguez
mesh_terms: D000818:Animals; D000943:Antigens, Differentiation / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D008168:Lung / Q000166:cytology / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D010587:Phagocytosis; D011650:Pulmonary Alveoli / Q000166:cytology / Q000276:immunology; D051381:Rats; D011916:Rats, Inbred F344; D011961:Receptors, Fc / Q000276:immunology; D017452:Receptors, IgG; D007507:Therapeutic Irrigation
chemical_list: D000943:Antigens, Differentiation; D011961:Receptors, Fc; D017452:Receptors, IgG