Influence of urapidil on in vitro platelet response to adrenaline and other aggregating agents.
The effects of hypotensive drug urapidil on human platelet functions were investigated. Urapidil failed to evidence direct aggregating properties or potentiating effects. Furthermore, drug high concentrations inhibited the platelet response to ADP, PAF, collagen, adrenaline and bovine thrombin, and influenced the platelet release reaction induced by ADP and PAF. Data indicate that urapidil possesses negligible agonistic effects on human platelet alpha 2-adrenoceptors and interferes at high concentrations with the platelet activation, as evidenced for other anti-aggregating compounds.
Emanuelli
G
G
Institute of Internal Medicine, University of Turin, Ospedale S. Luigi Gonzaga, Italy.
Anfossi
G
G
Lanzio
M
M
Mularoni
E
E
Calcamuggi
G
G
Brunello
F
F
Busca
G P
GP
Ciani
D
D
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010978:Platelet Factor 4 / Q000032:analysis; D013917:Thrombin / Q000494:pharmacology; D001620:beta-Thromboglobulin / Q000097:blood
D000959:Antihypertensive Agents; D010879:Piperazines; D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; D000244:Adenosine Diphosphate; D003094:Collagen; C015568:urapidil; D013917:Thrombin; D004837:Epinephrine