Diagnosis and analysis of the clinical course of T-phenotype acute lymphoblastic leukemia.
We refer to the diagnostic possibilities in T-phenotype acute lymphoblastic leukemia. Immunophenotyping based on the proof of T-differentiation antigens by means of specific monoclonal antibodies and assessment of the E receptor, as well as examination of enzymatic activities of adenosine deaminase and purinenucleoside phosphorylase, were performed. Thirty patients with acute lymphoblastic leukemia of T-phenotype were examined. The monoclonal antibodies used demonstrated a heterogeneity in this type of leukemia reflecting the stage of thymocyte differentiation. The cells of some patients with T-phenotype acute lymphoblastic leukemia expressed simultaneously the common acute lymphoblastic leukemia antigen and Ia molecules. Examination of enzyme activities demonstrated a characteristic pattern with a significantly increased adenosine deaminase activity and simultaneously decreased purinenucleoside phosphorylase activity in T-phenotype acute lymphoblastic leukemia. The unfavorable course of disease in patients with T-phenotype acute lymphoblastic leukemia was demonstrated analyzing a group of 50 children with acute lymphoblastic leukemia. By means of statistical methods the cumulative rate of children surviving with acute lymphoblastic leukemia of common and T-phenotypes have been expressed. The results showed the need for a more effective treatment aimed at the T-phenotype of acute lymphoblastic leukemia.
Babusíková
O
O
Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Hrivnáková
A
A
Cáp
J
J
Ujházy
P
P
D000243:Adenosine Deaminase / Q000097:blood*; D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000097:blood*; D002648:Child; D004796:Clinical Enzyme Tests; D005455:Fluorescent Antibody Technique; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis* / Q000276:immunology; D009367:Neoplasm Staging; D015260:Neprilysin; D009700:Nucleoside Deaminases / Q000097:blood*; D010430:Pentosyltransferases / Q000097:blood*; D010641:Phenotype; D011379:Prognosis; D011683:Purine-Nucleoside Phosphorylase / Q000097:blood*; D012016:Reference Values; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D010430:Pentosyltransferases; D011683:Purine-Nucleoside Phosphorylase; D015260:Neprilysin; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase