[Effect of x-irradiation on the generation of O2- in rat liver microsomes].
A study was made of generation of O2- in NADPH-dependent chain of oxidation of liver microsomes in irradiated rats (7 and 10 Gy). The rate of O2- generation sharply increased at early times after irradiation. The data obtained prompt an assumption that the increase in the rate of O2- generation is perhaps connected with the changes in functioning of both NADPH-cytochrome P-450-reductase and cytochrome P-450.
Gorodovikova
E N
EN
Gudz'
T I
TI
Goncharenko
E N
EN
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D008054:Lipid Peroxides / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism / Q000528:radiation effects*; D010084:Oxidation-Reduction; D011833:Radiation Injuries, Experimental / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism / Q000528:radiation effects; D013481:Superoxides / Q000378:metabolism / Q000528:radiation effects*; D014916:Whole-Body Irradiation
D008054:Lipid Peroxides; D013481:Superoxides; D003577:Cytochrome P-450 Enzyme System; D013482:Superoxide Dismutase
Vliianie rentgenovskogo oblucheniia na generatsiiu O2- v mikrosomakh pecheni krys.