[Mechanism of tumor promotion].
Various kinds of calmodulin-interacting agents have been proved to suppress tumor promotion in vivo. In this study, we further demonstrate that flunarizine and dehydroepiandrosterone, which are proved to interact with calmodulin, showed antitumor-promoting activity in two-stage carcinogenesis of mouse skin. These results indicate that Ca2+/-calmodulin system, may play an important role in tumor promotion.
Nishino
H
H
Département de Biochimie, Université Médicale de la Préfecture de Kyoto, Japon.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism*; D002273:Carcinogens / Q000037:antagonists & inhibitors; D003687:Dehydroepiandrosterone / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D005444:Flunarizine / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control; D012878:Skin Neoplasms / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control
D001095:Arachidonic Acids; D002147:Calmodulin; D002273:Carcinogens; D016718:Arachidonic Acid; D003687:Dehydroepiandrosterone; D015127:9,10-Dimethyl-1,2-benzanthracene; D005444:Flunarizine; D002118:Calcium
Mécanisme de la promotion des tumeurs.