Lithium incorporation in the fibroblasts of manic-depressives.
Lithium incorporation in cultured human skin fibroblasts was measured in a group of 10 manic-depressives and 10 controls. This system was believed to eliminate many of the sources of variability to which measurement of the lithium ratio in erythrocytes (RBCs) is subject. A fibroblast lithium ratio calculated from 1-hr lithium incorporation studies correlated highly with an in vitro RBC lithium ratio in medication-free controls. Manic-depressives and controls did not differ in lithium incorporation or fibroblast lithium ratio, leading to the conclusion that the lithium ratio is probably not a good measure for differentiating the two populations.
Breslow
R E
RE
DeMuth
G W
GW
Weiss
C
C
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000188:drug therapy / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism* / Q000627:therapeutic use; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008094:Lithium / Q000378:metabolism* / Q000627:therapeutic use; D018021:Lithium Chloride; D008297:Male; D008875:Middle Aged
D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride