title: PK 11195, an antagonist of peripheral benzodiazepine receptors, reduces ventricular arrhythmias during myocardial ischemia and reperfusion in the dog.
abstract: PK 11195, an antagonist of peripheral type benzodiazepine receptors, in doses from 5 to 25 mg/kg i.d. protected in a dose-dependent manner dogs against both early and delayed ventricular arrhythmias induced by 20 min ischemia and against ventricular fibrillation following reperfusion. Thus, peripheral-type benzodiazepine receptors might represent a novel target in the treatment of angina and cardiac ischemia.
authors.forename: M
authors.initials: M
authors.lastname: Mestre
authors.forename: G
authors.initials: G
authors.lastname: Bouetard
authors.forename: A
authors.initials: A
authors.lastname: Uzan
authors.forename: C
authors.initials: C
authors.lastname: Gueremy
authors.forename: C
authors.initials: C
authors.lastname: Renault
authors.forename: M C
authors.initials: MC
authors.lastname: Dubroeucq
authors.forename: G
authors.initials: G
authors.lastname: Le Fur
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000150:complications / Q000503:physiopathology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D011963:Receptors, GABA-A / Q000187:drug effects*
chemical_list: D000889:Anti-Arrhythmia Agents; D007546:Isoquinolines; D011963:Receptors, GABA-A; C037850:PK 11195