title: The vasodilator effect of human atrial natriuretic factor (99-126) on human omental arteries.
abstract: The effect of synthetic human atrial natriuretic factor [ANF-(99-126)] on human omental arteries was investigated. The compound produced concentration-dependent relaxation, 10, 50 and 90% of maximum effect being observed at about 1, 10 and 100 nmol/l, respectively. These concentrations are considerably higher than those measured by radio-immunoassay in human plasma, even under extreme conditions (0.001-0.3 nmol/l). Therefore, ANF can dilate human resistance-size arteries, but whether it does so under physiological conditions has not been established.
authors.affiliation: Istituto di Clinica Medica e Nefrologia, Università di Parma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bruschi
authors.forename: M E
authors.initials: ME
authors.lastname: Bruschi
authors.forename: G
authors.initials: G
authors.lastname: Orlandini
authors.forename: E
authors.initials: E
authors.lastname: Banchini
authors.forename: A
authors.initials: A
authors.lastname: Borghetti
mesh_terms: D000328:Adult; D000818:Animals; D001158:Arteries / Q000187:drug effects*; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D051381:Rats; D014664:Vasodilation / Q000187:drug effects*
chemical_list: C472955:NPPA protein, human; D009320:Atrial Natriuretic Factor