Tretinoin-sunscreen mixture in the treatment of acne vulgaris.
In an open design study of fifty-four patients with grade I or grade II acne vulgaris, the combination of 0.1 percent tretinoin cream (Retin-A) and a sunscreen with sun protection factor 15 (Sundown) was evaluated. Overall study results of the forty-six patients who could be evaluated demonstrated a decrease in papule count of 25.9 percent, a decrease in closed comedones of 49.1 percent, and a decrease in open comedones of 36.3 percent by the end of the eight-week study period. These results indicate that the addition of a noncomedogenic sunscreen to tretinoin did not compromise its effectiveness and successfully prevented photoaccentuation reactions.
Cullen
S I
SI
Department of Medicine (Dermatology), University of Florida School of Medicine, Gainesville 32605.
Childers
R C
RC
D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D002648:Child; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010787:Photosensitivity Disorders / Q000139:chemically induced / Q000517:prevention & control; D013473:Sunscreening Agents / Q000627:therapeutic use*; D014212:Tretinoin / Q000008:administration & dosage* / Q000009:adverse effects
D004338:Drug Combinations; D013473:Sunscreening Agents; D014212:Tretinoin