Hypothalamic control of lipid metabolism.
Obesity as a common disorder of lipid metabolism might be caused by defective hypothalamic control as demonstrated by ventromedial lesions or the effect of cholecystokinin application. The hypothalamic proopiomelanocorticotropin is the precursor of hormonal fragments affecting fat mobilisation, the endocrine pancreas and gastrointestinal functions.
Schwandt
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D000818:Animals; D002766:Cholecystokinin / Q000502:physiology; D004435:Eating; D004723:Endorphins / Q000502:physiology; D005934:Glucagon / Q000097:blood; D006801:Humans; D007027:Hypothalamic Diseases / Q000503:physiopathology*; D007328:Insulin / Q000097:blood; D007408:Intestinal Absorption; D008053:Lipid Mobilization; D008055:Lipids / Q000097:blood*; D008066:Lipolysis; D009765:Obesity / Q000503:physiopathology*; D011333:Pro-Opiomelanocortin / Q000502:physiology; D011957:Receptors, Opioid / Q000502:physiology; D012528:Satiety Response / Q000502:physiology; D014630:Vagus Nerve / Q000503:physiopathology; D001615:beta-Endorphin
D004723:Endorphins; D007328:Insulin; D008055:Lipids; D011957:Receptors, Opioid; D001615:beta-Endorphin; D011333:Pro-Opiomelanocortin; D005934:Glucagon; D002766:Cholecystokinin