Mutual inhibitory effect of calpastatins on calpains from carp muscle, carp erythrocytes and rat liver.
The inhibitory effect of calpastatin (specific inhibitor for calpain) on calpain (Ca2+-dependent cysteine proteinase, EC 3.4.22.17) was examined using carp muscle, carp erythrocytes and rat liver preparations. A mutual inhibitory effect between calpains and calpastatins from different tissues and species was observed. The conservation of the inhibitory effect of calpastatin on calpain among vertebrates suggests that the calpain-calpastatin system may play a biologically fundamental and common role in various cells.
Toyohara
H
H
Makinodan
Y
Y
Tanaka
K
K
Ikeda
S
S
D000818:Animals; D002135:Calcium-Binding Proteins / Q000494:pharmacology*; D002154:Calpain; D002347:Carps; D004912:Erythrocytes / Q000201:enzymology*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D009132:Muscles / Q000201:enzymology*; D009928:Organ Specificity; D011480:Protease Inhibitors / Q000494:pharmacology*; D051381:Rats; D013045:Species Specificity
D002135:Calcium-Binding Proteins; D011480:Protease Inhibitors; C033668:calpastatin; D002154:Calpain