title: Twenty-four-hour intragastric acidity and plasma gastrin concentration in healthy subjects and patients with duodenal or gastric ulcer, or pernicious anaemia.
abstract: Twenty-four-hour intragastric acidity and plasma gastrin concentration were measured in healthy subjects (n = 16), and patients with duodenal (n = 12) or gastric (n = 10) ulceration, or pernicious anaemia (n = 8). Median integrated 24-hour intragastric acidity was highest in duodenal ulcer patients and lowest in pernicious anaemia patients (1148 and 0 mmol.hour litre-1, respectively). Median integrated 24-hour plasma gastrin was highest in pernicious anaemia and lowest in the healthy subjects (9886 and 238 pmol.hour litre-1, respectively). Pernicious anaemia patients have unremitting hypergastrinaemia throughout the 24 hours. The results of this study not only provide a reference range of acidity and plasma gastrin in health and disease, but also will act as a baseline for future studies using antisecretory drugs.
authors.affiliation: Academic Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Lanzon-Miller
authors.forename: R E
authors.initials: RE
authors.lastname: Pounder
authors.forename: M R
authors.initials: MR
authors.lastname: Hamilton
authors.forename: N A
authors.initials: NA
authors.lastname: Chronos
authors.forename: S
authors.initials: S
authors.lastname: Ball
authors.forename: J E
authors.initials: JE
authors.lastname: Mercieca
authors.forename: M
authors.initials: M
authors.lastname: Olausson
authors.forename: C
authors.initials: C
authors.lastname: Cederberg
mesh_terms: D000328:Adult; D000368:Aged; D000752:Anemia, Pernicious / Q000097:blood / Q000503:physiopathology*; D002940:Circadian Rhythm; D004381:Duodenal Ulcer / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013276:Stomach Ulcer / Q000097:blood / Q000503:physiopathology*
chemical_list: D005755:Gastrins