title: The cholinergic hypothesis: a historical overview, current perspective, and future directions.
authors.forename: R T
authors.initials: RT
authors.lastname: Bartus
authors.forename: R L
authors.initials: RL
authors.lastname: Dean
authors.forename: M J
authors.initials: MJ
authors.lastname: Pontecorvo
authors.forename: C
authors.initials: C
authors.lastname: Flicker
mesh_terms: D000109:Acetylcholine / Q000502:physiology; D000110:Acetylcholinesterase / Q000378:metabolism; D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002799:Cholinergic Fibers / Q000503:physiopathology*; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D011939:Mental Recall / Q000502:physiology; D010277:Parasympathomimetics / Q000627:therapeutic use; D051381:Rats; D011950:Receptors, Cholinergic / Q000502:physiology*; D012153:Retention, Psychology / Q000502:physiology; D013377:Substantia Innominata / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D010277:Parasympathomimetics; D011950:Receptors, Cholinergic; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase; D000109:Acetylcholine