Sigma opioid receptors; SKF-10,047 update.
We found that (-)-SKF-10,047 blocks EEG and behavioral effects of morphine in the naive rat, precipitates withdrawal in morphine-dependent rats, produces physical dependence as evidenced by naloxone-induced withdrawal, and displaces [3H] dihydromorphine from brain homogenates. (+)-SKF-10,047 did not produce dependence upon chronic treatment, and it did not displace [3H] dihydromorphine from brain homogenates. Such pharmacodynamic dissociation of SKF-10,047 effects suggests an association of sigma receptors with psychotogenic, but not opioid characteristics. The latter are most likely mediated by mu or kappa receptors.
Khazan
N
N
Young
G A
GA
el-Fakahany
E E
EE
Hong
O
O
Calligaro
D
D
D000818:Animals; D004569:Electroencephalography; D005260:Female; D006213:Hallucinogens / Q000494:pharmacology*; D009020:Morphine / Q000037:antagonists & inhibitors; D009270:Naloxone / Q000494:pharmacology; D010620:Phenazocine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects*; D017480:Receptors, sigma; D013237:Stereoisomerism
D006213:Hallucinogens; D011957:Receptors, Opioid; D017480:Receptors, sigma; D009270:Naloxone; C012134:SK&F 10047; D009020:Morphine; D010620:Phenazocine