[Pharmacokinetics of ceftazidime in cystic fibrosis].
Ceftazidime has been recognized as an invaluable antibiotic for the treatment of lower respiratory infections in patients with cystic fibrosis. In these patients the apparent volume of distribution of ceftazidime is increased. Its clearance is besides increased, with a significant reduction in the area under concentrations curve. The distribution of ceftazidime in the bronchi seems to be very satisfactory. It results from these data that dosage in children with cystic fibrosis may reach 200 to 300 mg/kg/day divided into 3 or 4 injections. The intrabronchial administration of ceftazidime has not proved effective.
Saint Raymond
A
A
Service du Pr J. Rey, Hôpital des Enfants malades, Paris.
Genillier
P
P
Lenoir
G
G
D001980:Bronchi / Q000378:metabolism; D002442:Ceftazidime / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D003550:Cystic Fibrosis / Q000097:blood*; D006801:Humans; D013997:Time Factors
D002442:Ceftazidime
Pharmacocinétique de la ceftazidime dans la mucoviscidose.