Effects of aspirin, naloxone and placebo.
This study was designed to examine the effects of aspirin, naloxone and placebo treatment on serum beta-endorphin concentration and joint pain in patients with rheumatoid arthritis (RA). Ten patients with definite or classical RA were studied. All treatments were administered in a randomized sequence. On each study day, the following measurements were carried out at specified time intervals: serum beta-endorphin concentration, serum salicylate concentration and joint pain score on a visual analogue horizontal scale. We conclude that in patients with rheumatoid arthritis suffering from chronic joint pain, serum beta-endorphin does not appear to play a role in pain relief.
Mewa
A A
AA
Department of Medicine, McMaster University Health Science Centre, Hamilton, Ontario, Canada.
Rosenbloom
D
D
Grace
E M
EM
Brooks
P
P
Bellamy
N
N
Denko
C
C
Norman
G
G
Buchanan
W W
WW
D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000503:physiopathology; D001241:Aspirin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D009270:Naloxone / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000097:blood / Q000188:drug therapy*; D010147:Pain Measurement; D010919:Placebos; D011897:Random Allocation; D001615:beta-Endorphin / Q000097:blood
D010919:Placebos; D009270:Naloxone; D001615:beta-Endorphin; D001241:Aspirin