Tissue-derived biomaterials and their use in cardiovascular prosthetic devices.
A variety of tissues and tissue components, ranging from allograft and xenograft tissues to albumin- and collagen-coated synthetic materials, have been used to fabricate cardiovascular prosthetic devices. Tissue-derived biomaterials include both viable and non-viable tissues as well as individual tissue components which have undergone some degree of preimplantation processing. A review of the biochemistry, immunogenicity, mechanical properties, physicochemical properties, preimplantation processing and the morphology of the following cardiovascular prostheses are discussed: heart valve bioprostheses and allografts; blood vessel allografts; biologic vascular grafts; and, protein-coated vascular prostheses. This review focuses on the generic aspects of prosthetic device fabrication using tissue-derived biomaterials, realizing that specific differences between various commercially available prostheses may exist.
Hilbert
S L
SL
Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland.
Ferrans
V J
VJ
Jones
M
M
D000818:Animals; D001672:Biocompatible Materials; D001705:Bioprosthesis; D001807:Blood Vessel Prosthesis; D006350:Heart Valve Prosthesis; D006801:Humans; D008854:Microscopy, Electron; D011474:Prosthesis Design
D001672:Biocompatible Materials