title: Role of helper T-lymphocytes in rejection of UV-induced murine skin cancers.
abstract: The purpose of this study was to examine the role of helper T-lymphocytes (Th) in the immunological rejection of UV-induced tumors. Mice repeatedly exposed to UV radiation develop suppressor T-lymphocytes that facilitate the growth of UV-induced tumors by interfering with host immunity. These suppressor cells specifically blocked the generation of antitumor Th, suggesting that Th may be important in the immunological rejection of UV-induced tumors. The Th activity generated by a UV-induced tumor that grows progressively in normal mice was compared with that generated by a highly antigenic, regressor clone of the same tumor. The regressing tumor cell line generated a much higher amount of Th activity than the parental, progressor tumor cell line. The amount of Th activity generated by a highly antigenic, UV-induced tumor injected into normal mice, in which it regresses, was compared to the Th activity in UV-irradiated mice, in which the tumor grows progressively. Again, tumor regression was associated with a higher amount of Th activity, and this increased activity was detectable in the environment of the regressing tumor. Lyt-1+ cells containing Th activity mediated the regression of a UV-induced tumor when injected with the tumor cells s.c. into immunosuppressed mice. Lyt-1- cells were cytotoxic to tumor cells in vitro but were unable to cause tumor rejection in vivo. These studies suggest that Th play a central role in the immunological rejection of UV-induced tumors.
authors.affiliation: Department of Immunology, University of Texas, M.D. Anderson Hospital and Tumor Institute, Houston 77030.
authors.forename: C A
authors.initials: CA
authors.lastname: Romerdahl
authors.forename: M L
authors.initials: ML
authors.lastname: Kripke
mesh_terms: D000818:Animals; D005260:Female; D007116:Immunization, Passive; D051379:Mice; D008809:Mice, Inbred C3H; D009381:Neoplasms, Radiation-Induced / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014466:Ultraviolet Rays / Q000009:adverse effects*