Mucopolysaccharide polysulphate cream in the prevention of pressure sores--a double blind study.
Early pressure areas in 38 cases (33 patients) were randomly treated twice daily with topical applications of either mucopolysaccharide polysulphate (MPS) or the cream base. The patients were assessed weekly for 4 weeks, the main parameter being change in the area of the pressure area. In the MPS group a significant reduction in size was obtained during the 2nd week of treatment, while in the control group a significant reduction was not obtained until week 4. At the end of the treatment, 59% (10/17) of the MPS group were fully healed compared with 21% (4/19) of the control group, the difference being statistically significant, p less than 0.05. MPS resembles heparin chemically, and the results could be attributed to an improvement in the microcirculation and nutrition of the perivascular tissue through an inhibition of microthrombi and perivascular fibrin deposition.
Kuisma
I
I
Roihuvuori Nursing Home, Herttoniemi Hospital, Helsinki, Finland.
Tamelander
G
G
D000368:Aged; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006025:Glycosaminoglycans / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D009824:Ointments; D003668:Pressure Ulcer / Q000517:prevention & control*; D011897:Random Allocation; D014945:Wound Healing / Q000187:drug effects
D006025:Glycosaminoglycans; D009824:Ointments; C052717:mucopolysaccharide polysulfate