title: Analysis of T cell subsets in different clinical subgroups of patients with the acquired immune deficiency syndrome. Comparison with the "classic" form of Kaposi's sarcoma.
abstract: Ninety patients were grouped according to three different forms of acquired immune deficiency syndrome (AIDS): Kaposi's sarcoma "recent outbreak" type (38), reactive lymphadenopathy (27), and opportunistic infections (17), and a fourth group of patients with "classic" Kaposi's sarcoma (8). All patients with "classic" Kaposi's sarcoma were previously treated with electron-beam irradiation. These four groups were compared with 40 normal control subjects. Peripheral blood mononuclear cells isolated by density separation were reacted with a panel of mouse monoclonal antibodies that recognizes all peripheral blood T cells (OKT3-positive), helper (OKT4-positive), and suppressor (OKT8-positive) T cell subsets. The OKT4/OKT8 ratio was used to define the balance between these two subsets. All three groups with AIDS with or without Kaposi's sarcoma showed a decrease in the OKT4/OKT8 ratio. The group with "classic" Kaposi's sarcoma showed individual T cell subset values that were also abnormal. These findings confirm the previously reported imbalance of T cell subsets in patients with AIDS and Kaposi's sarcoma, which is also evident in patients with treated "classic" Kaposi's sarcoma.
authors.forename: A
authors.initials: A
authors.lastname: Mittelman
authors.forename: G
authors.initials: G
authors.lastname: Wong
authors.forename: B
authors.initials: B
authors.lastname: Safai
authors.forename: P
authors.initials: P
authors.lastname: Myskowski
authors.forename: J
authors.initials: J
authors.lastname: Gold
authors.forename: B
authors.initials: B
authors.lastname: Koziner
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000145:classification / Q000276:immunology*; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D001706:Biopsy; D017977:Deltaretrovirus / Q000276:immunology; D006801:Humans; D006965:Hyperplasia; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal