Atrial natriuretic peptide production in association with nonimmune fetal hydrops.
The presence and elevation of atrial natriuretic peptide in fetuses has not previously been demonstrated. This study of right atrial pacing in fetal lambs demonstrated a threefold to fourfold increase in atrial natriuretic peptide during the production of fetal hydrops. Its rate of return to a normal level paralleled the clearance of fetal hydrops. Its possible role in fetal cardiovascular hemodynamics is discussed.
Nimrod
C
C
Department of Obstetrics, Faculty of Medicine, University of Calgary, Alberta, Canada.
Keane
P
P
Harder
J
J
Davies
D
D
Kondo
C
C
Takahashi
Y
Y
Wong
T
T
Maloney
J
J
Nicholson
S
S
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000096:biosynthesis* / Q000097:blood; D004487:Edema / Q000209:etiology / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005315:Fetal Diseases / Q000209:etiology / Q000378:metabolism*; D005333:Fetus / Q000378:metabolism; D011247:Pregnancy; D012756:Sheep; D013610:Tachycardia / Q000150:complications
D009320:Atrial Natriuretic Factor