Caffeine stimulates in vivo platelet reactivity.
The effect of coffee drinking on platelet reactivity was studied in 12 healthy subjects. Plasma beta-thromboglobulin concentration was determined before and one hour after administration of 100 mg of caffeine, corresponding to one cup of coffee. Mean values were 47.0 +/- 19.3 and 179.3 +/- 85.5 ng/ml before and after caffeine administration respectively. The increase, 298 +/- 150%, is highly significant (p less than 0.001).
Ammaturo
V
V
Department of Hematology, University of Naples, Italy.
Perricone
C
C
Canazio
A
A
Ripaldi
M
M
Ruggiano
A
A
Zuccarelli
B
B
Monti
M
M
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects*; D002110:Caffeine / Q000494:pharmacology*; D003069:Coffee; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D001620:beta-Thromboglobulin / Q000097:blood*
D003069:Coffee; D001620:beta-Thromboglobulin; D002110:Caffeine