title: Genetic control of chromosome length in yeast.
abstract: The chromosomes of the yeast Saccharomyces cerevisiae terminate with sequences that have the form poly(C1-3-A). In this paper, we show that within an individual yeast strain all chromosomes end with tracts of poly(C1-3-A) of similar lengths; however, different strains can have tracts that vary in length by a factor of two. By a genetic analysis, we demonstrate that yeast cells have a mechanism that allows them to change rapidly the length of their chromosomes by altering the length of the poly(C1-3-A) tract.
authors.forename: R M
authors.initials: RM
authors.lastname: Walmsley
authors.forename: T D
authors.initials: TD
authors.lastname: Petes
mesh_terms: D001483:Base Sequence; D002875:Chromosomes / Q000032:analysis*; D004261:DNA Replication; D004262:DNA Restriction Enzymes / Q000378:metabolism; D004587:Electrophoresis, Agar Gel; D008540:Meiosis; D009690:Nucleic Acid Conformation; D011061:Poly A / Q000032:analysis*; D011066:Poly C / Q000032:analysis*; D011131:Polyribonucleotides / Q000032:analysis*; D012091:Repetitive Sequences, Nucleic Acid; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D011131:Polyribonucleotides; D011061:Poly A; C023794:poly(A-C); D011066:Poly C; D004262:DNA Restriction Enzymes