title: [Thyroid function and trisomy 21. TSH increase and rT3 deficiency].
abstract: An excess of thyrotropin (TSH) with normal levels of tetraiodothyronine (T4) and of 3,5,3'-triiodothyronine (T3) was confirmed in the serum of 78 trisomy 21 children. A severe deficiency of 3,3',5'-triiodo-thyronine (rT3 or reverse T3) was observed and the decrease of the rT3/TSH ratio was highly significant. These new facts suggest that the rT3 deficiency plays a peculiar role in trisomy 21 (maybe through the regulation of one or few steps of monocarbons' metabolism). A systematic control of thyroid function (including the patient's rT3 level) is mandatory for the follow-up of every trisomy 21 patient.
authors.affiliation: Institut de Progenèse, Centre Claude Bernard sur les Maladies de l'Intelligence, Paris.
authors.forename: J
authors.initials: J
authors.lastname: Lejeune
authors.forename: M
authors.initials: M
authors.lastname: Peeters
authors.forename: M C
authors.initials: MC
authors.lastname: de Blois
authors.forename: M
authors.initials: M
authors.lastname: Bergère
authors.forename: A
authors.initials: A
authors.lastname: Grillot
authors.forename: M O
authors.initials: MO
authors.lastname: Rethoré
authors.forename: G
authors.initials: G
authors.lastname: Vallée
authors.forename: M
authors.initials: M
authors.lastname: Izembart
authors.forename: J P
authors.initials: JP
authors.lastname: Devaux
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008958:Models, Molecular; D012016:Reference Values; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014285:Triiodothyronine, Reverse / Q000097:blood* / Q000172:deficiency
chemical_list: D014285:Triiodothyronine, Reverse; D013972:Thyrotropin; D013974:Thyroxine
vernacular_title: Fonction thyroïdienne et trisomie 21 excès de TSH et déficit en rT3.