Are there genetic determinants for the glucose intolerance of acromegaly?
A genetic marker identifying the two parental insulin genes has been studied in 51 Caucasian acromegalics by Southern blot hybridization techniques using a cloned insulin gene probe. Two main DNA insertion classes were detected corresponding to the class 1 and class 3 alleles and thus the following genotypes were found: 1/1, 1/3 and 3/3. The acromegalics were subdivided depending on whether they had a normal (n = 30) or abnormal (n = 21) response to a 50 gm oral glucose tolerance test before treatment. The phenotype frequencies in the former group were 1/1, 43%; 1/3, 53%; and 3/3, 4%; and in the latter group the corresponding figures were 76%, 24% and 0%. The relative incidence of concordance of the phenotype 1/1 with abnormal glucose tolerance in acromegaly was 4.2. This phenotype is also associated with insulin dependent (Type 1) diabetes mellitus.
Hitman
G A
GA
Katz
J
J
Lytras
N
N
Jowett
N I
NI
Wass
J A
JA
Besser
G M
GM
Galton
D J
DJ
D000172:Acromegaly / Q000235:genetics* / Q000378:metabolism; D004251:DNA Transposable Elements; D005260:Female; D005819:Genetic Markers; D005947:Glucose / Q000235:genetics / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype
D004251:DNA Transposable Elements; D005819:Genetic Markers; D007328:Insulin; D005947:Glucose