[Thyroid function and trisomy 21. TSH increase and rT3 deficiency].
An excess of thyrotropin (TSH) with normal levels of tetraiodothyronine (T4) and of 3,5,3'-triiodothyronine (T3) was confirmed in the serum of 78 trisomy 21 children. A severe deficiency of 3,3',5'-triiodo-thyronine (rT3 or reverse T3) was observed and the decrease of the rT3/TSH ratio was highly significant. These new facts suggest that the rT3 deficiency plays a peculiar role in trisomy 21 (maybe through the regulation of one or few steps of monocarbons' metabolism). A systematic control of thyroid function (including the patient's rT3 level) is mandatory for the follow-up of every trisomy 21 patient.
Lejeune
J
J
Institut de Progenèse, Centre Claude Bernard sur les Maladies de l'Intelligence, Paris.
Peeters
M
M
de Blois
M C
MC
Bergère
M
M
Grillot
A
A
Rethoré
M O
MO
Vallée
G
G
Izembart
M
M
Devaux
J P
JP
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008958:Models, Molecular; D012016:Reference Values; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014285:Triiodothyronine, Reverse / Q000097:blood* / Q000172:deficiency
D014285:Triiodothyronine, Reverse; D013972:Thyrotropin; D013974:Thyroxine
Fonction thyroïdienne et trisomie 21 excès de TSH et déficit en rT3.