Experimental data on the problem of specific hepatosplenography with radiodense lipomicrons.
Investigations into specific hepatosplenography performed with the aid of radiodense lipomicrons of different size ranges and various surface layers are presented. It is concluded that certain synthetic neutral and/or negatively charged amphiphilic substances may enhance hepatic and splenic uptake of small lipomicrons. Kinetics concerning clearance of lipid globules from the blood and hepatic concentration as well as elimination rates are studied. Furthermore, circulatory reactions following the intravenous administration of lipid emulsions and interactions between lipid globules and plasma proteins or synthetic polymeric substances are discussed.
Schumacher
K A
KA
Weidenmaier
W E
WE
Rüppel
D A
DA
Classen
H G
HG
D000818:Animals; D003287:Contrast Media; D005217:Fat Emulsions, Intravenous / Q000633:toxicity; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007459:Iodized Oil / Q000633:toxicity; D007700:Kinetics; D008099:Liver / Q000000981:diagnostic imaging*; D008297:Male; D010316:Particle Size; D011817:Rabbits; D011859:Radiography; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000000981:diagnostic imaging*; D013499:Surface Properties; D013997:Time Factors
D003287:Contrast Media; D005217:Fat Emulsions, Intravenous; D007459:Iodized Oil