A proposed occupational exposure limit for 2,3,7,8-tetrachlorodibenzo-p-dioxin.
One contaminant produced unintentionally during the manufacture of chlorophenols and phenoxy herbicides is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The resulting TCDD-containing wastes have been detected at many hazardous waste sites which in recent years have been in the process of remediation. Concerns about worker exposure to TCDD-contaminated soil (dust) during remediation of hazardous waste sites have produced a need for an occupational exposure limit (OEL) for TCDD. The animal toxicology data and human experience with TCDD are reviewed, and an occupational exposure limit for TCDD is proposed. The animal data support risk estimations which are based on TCDD as a nongenotoxic carcinogen. Studies on human populations have failed to demonstrate clearly any significant long-term health effects at levels to which humans have been exposed. The data indicate that an 8-hr time-weighted average limit of 2 ng/m3 is appropriate, and the associated risk would be consistent with other carcinogens at their corresponding OELs. A preliminary OEL of 0.2 ng/m3 (200 pg/m3) is recommended, however, in light of other sources of exposure because of TCDD's ubiquitousness in the environment, its unclear mechanism of action, and its rather long biological half-life in humans. This limit provides an ample margin of safety to prevent chloracne following repeated, acute exposure, and it addresses those chronic effects of TCDD observed in animal studies as well as those observed after accidental human exposure. The resulting body burden caused by chronic exposure to TCDD at the proposed OEL is examined. Its toxicological significance is compared with human tissue data and with other similarly persistent chemicals.(ABSTRACT TRUNCATED AT 250 WORDS)
Leung
H W
HW
Environmental Health and Safety, Syntex, Inc., Palo Alto, CA 94303.
Murray
F J
FJ
Paustenbach
D J
DJ
D000152:Acne Vulgaris / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens; D004147:Dioxins / Q000009:adverse effects / Q000633:toxicity; D006801:Humans; D008452:Maximum Allowable Concentration; D009153:Mutagens; D009784:Occupational Diseases / Q000139:chemically induced; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects / Q000633:toxicity; D013723:Teratogens
D002273:Carcinogens; D004147:Dioxins; D009153:Mutagens; D000072317:Polychlorinated Dibenzodioxins; D013723:Teratogens