title: [Comparative pharmacological characteristics of peptides of the atrial natriuretic factor family].
abstract: Comparative antihypertensive and natriuretic activities of atrial natriuretic factor (ANF) and its nearest shortened analogues--atriopeptines (AP) were studied in vivo on narcotized rats; and their peripheral vasodilating activities were studied in vitro on isolated rings of rat's thoracic aorta. The results obtained in vivo allow a following series of comparative antihypertensive and vasodilating activity: alpha rANF greater than APII greater than AP7-27. alpha rANF, APIII and APII did not differ significantly in vasodilating activity on isolated vessels; analogue 7-27 was less active. Thus further search of highly active shortened atriopeptin analogues is necessary for developing new drugs on their basis.
authors.forename: Zh D
authors.initials: ZhD
authors.lastname: Bespalova
authors.forename: V A
authors.initials: VA
authors.lastname: Vinogradov
authors.forename: S V
authors.initials: SV
authors.lastname: Zhukovskiĭ
authors.forename: M I
authors.initials: MI
authors.lastname: Kaĭkov
authors.forename: N V
authors.initials: NV
authors.lastname: Korobov
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents; D001012:Aorta, Abdominal / Q000187:drug effects; D009320:Atrial Natriuretic Factor / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014665:Vasodilator Agents
chemical_list: D000959:Antihypertensive Agents; D014665:Vasodilator Agents; D009320:Atrial Natriuretic Factor
vernacular_title: Sravnitel'naia farmakologicheskaia kharakteristika peptidov semeĭstva atrial'nogo natriĭureticheskogo faktora.