title: Growth cone-target interactions in the frog retinotectal pathway.
abstract: The growth cones of retinal ganglion cell axons were studied in the optic tract and tectum with horseradish peroxidase (HRP) histochemistry and electron microscopy. The ganglion cell growth cones has many morphological features similar to those described in vitro and in other in vivo systems. However, we found that some processes formed highly differentiated terminal arborizations, while retaining growth cones on many of their branches. In addition, ultrastructural examination of the tectal neuropil revealed that many ganglion cell axonal processes had characteristics of both growth cones and presynaptic endings. These findings are discussed in the context of the hypothesis of shifting connections and the evidence that retinotectal map formation involves several mechanisms, including a process that depends on the action potential activity in the optic fibers.
authors.forename: T A
authors.initials: TA
authors.lastname: Reh
authors.forename: M
authors.initials: M
authors.lastname: Constantine-Paton
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D006735:Horseradish Peroxidase; D011894:Rana pipiens; D012160:Retina / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000502:physiology / Q000648:ultrastructure; D013477:Superior Colliculi / Q000502:physiology*; D009435:Synaptic Transmission; D014795:Visual Pathways / Q000502:physiology* / Q000648:ultrastructure
chemical_list: D006735:Horseradish Peroxidase