Nonspecific corticosteroid therapy in patients receiving intra-arterial chemotherapy for hepatic metastases of colorectal origin.
Cholestatic jaundice induced by hepatic intra-arterial 5-fluorodeoxyuridine (FUDR) demonstrated marked improvement in three patients following treatment with oral corticosteroids. Subsequent "prophylactic" use allowed continuation of chemotherapy and improved quality of life. Corticosteroid use in selected patients with FUDR-induced cholestatic jaundice may be beneficial.
Janis
L W
LW
University of Cincinnati School of Medicine, Ohio.
Leming
P D
PD
Leder
W
W
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D002779:Cholestasis / Q000139:chemically induced / Q000188:drug therapy; D003110:Colonic Neoplasms / Q000473:pathology*; D005467:Floxuridine / Q000009:adverse effects; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D012004:Rectal Neoplasms / Q000473:pathology*; D013866:Thioguanine / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D005467:Floxuridine; D013866:Thioguanine