title: [Biochemical mechanisms of fluorine action].
abstract: Biochemical mechanisms of fluorine ion action accounting for the biological role and significance of fluorine for vital activity of the organism are investigated. Results of these investigations are generalized. This trace element is shown to participate at least in two vitally important systems of the organism: the adenylate cyclase system which accounts for the cell response to neuroendocrinological information and the immune protection system providing antimicrobic resistance. Available data permit considering that cytotoxic fluorine action is based on the ability to hinder protein synthesis in eukaryotes and to stimulate peroxidation processes of biomembrane lipids. Inorganic fluorine compounds are recommended to be used with the treatment-and-prophylactic purpose for certain pathologic states, associated with its insufficient or excessive arrival into the organism.
authors.forename: V H
authors.initials: VH
authors.lastname: Okunev
authors.forename: V V
authors.initials: VV
authors.lastname: Zhirnov
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism; D005459:Fluorides / Q000494:pharmacology* / Q000502:physiology; D006801:Humans; D008054:Lipid Peroxides / Q000096:biosynthesis; D008563:Membrane Lipids / Q000378:metabolism; D014176:Protein Biosynthesis; D011956:Receptors, Cell Surface / Q000187:drug effects
chemical_list: D008054:Lipid Peroxides; D008563:Membrane Lipids; D011956:Receptors, Cell Surface; D000262:Adenylyl Cyclases; D005459:Fluorides
vernacular_title: Biokhimicheskie mekhanizmy deĭstviia ftora.