title: Effect of captopril on blood pressure and renal function in patients with transplant renal artery stenosis.
abstract: We evaluated 9 patients with transplant renal artery stenosis. Captopril treatment always resulted in a dramatic decrease in renal function. Moreover, only in patients (n = 2) with a stenosis in one out of more renal arteries a satisfying fall in blood pressure was achieved. Surgical reconstruction of the stenosis was successful in 4 out of 5 patients. Angiotensin I-converting enzyme inhibition in transplant renal artery stenosis often leads to loss of graft function, probably due to efferent vasodilation.
authors.forename: F J
authors.initials: FJ
authors.lastname: van der Woude
authors.forename: W J
authors.initials: WJ
authors.lastname: van Son
authors.forename: A M
authors.initials: AM
authors.lastname: Tegzess
authors.forename: A J
authors.initials: AJ
authors.lastname: Donker
authors.forename: M J
authors.initials: MJ
authors.lastname: Slooff
authors.forename: L B
authors.initials: LB
authors.lastname: van der Slikke
authors.forename: S J
authors.initials: SJ
authors.lastname: Hoorntje
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006978:Hypertension, Renovascular / Q000188:drug therapy* / Q000209:etiology; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D016030:Kidney Transplantation; D008297:Male; D011392:Proline / Q000031:analogs & derivatives*; D012078:Renal Artery Obstruction / Q000150:complications* / Q000601:surgery
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D011392:Proline; D002216:Captopril