title: Midazolam-sufentanil anaesthesia for phaeochromocytoma resection.
abstract: This is a case report of a 66-year-old patient to whom a combined infusion of midazolam and sufentanil was administered for phaeochromocytoma resection. With the exception of a drop in blood pressure immediately after tumour removal, significant intraoperative haemodynamic stability was observed. There was no need for the intraoperative administration of hypotensive or anti-arrhythmic drugs, nor was any prolonged postoperative anaesthetic effect noted. In this case, the combination of midazolam and sufentanil with N2O:O2 was successful in maintaining cardiovascular stability until the tumour was removed. The consequent drop in blood pressure responded to fluid infusion, a not uncommon event in phaeochromocytoma surgery. Although a prospective randomized study for resection of phaeochromocytoma showed that the choice of the anaesthetic technique is not a crucial factor in determining the patient outcome, we feel this technique of midazolam sufentanil is a worthy alternative to the use of inhalational anaesthetics. The lack of significant myocardial depressive effect of the two drugs, coupled with its simple administration, makes it a useful technique in the anaesthetic management of phaeochromocytoma resection.
authors.affiliation: Department of Anesthesiology, Rush Presbyterian St. Luke's Medical Center, Chicago, Illinois 60612.
authors.forename: J D
authors.initials: JD
authors.lastname: Shapiro
authors.forename: A
authors.initials: A
authors.lastname: el-Ganzouri
authors.forename: P F
authors.initials: PF
authors.lastname: White
authors.forename: A D
authors.initials: AD
authors.lastname: Ivankovich
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000601:surgery*; D000368:Aged; D000771:Anesthesia, Intravenous; D000777:Anesthetics; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives*; D006801:Humans; D008874:Midazolam; D010673:Pheochromocytoma / Q000601:surgery*; D017409:Sufentanil
chemical_list: D000777:Anesthetics; D017409:Sufentanil; D008874:Midazolam; D005283:Fentanyl