title: [Changes in the cAMP-dependent phosphorylation system of myocardial sarcoplasmic reticulum components during circulatory hypoxia].
abstract: The dissociation of the holoenzyme of the cAMP-dependent protein kinase was induced by the adrenaline-stimulated endogenous cAMP synthesis. This dissociation was impaired in a hypoxic muscle. The elevated proteolytic activity in the hypoxic area was found to be associated with the reduction of the 33P incorporation into phospholamban in the presence of 10(-6) M cAMP. No changes were observed when protein kinase was added to the incubation mixture. A correlation between the degree of phospholamban phosphorylation and its susceptibility to proteolysis was demonstrated.
authors.forename: A E
authors.initials: AE
authors.lastname: Antipenko
authors.forename: S N
authors.initials: SN
authors.lastname: Lyzlova
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002135:Calcium-Binding Proteins / Q000494:pharmacology; D003327:Coronary Disease / Q000201:enzymology / Q000209:etiology / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D004285:Dogs; D008861:Microsomes / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000201:enzymology; D012769:Shock / Q000150:complications / Q000201:enzymology / Q000378:metabolism*; D014357:Trypsin / Q000494:pharmacology; D000099211:Phospholamban
chemical_list: D000255:Adenosine Triphosphate; D002135:Calcium-Binding Proteins; D000242:Cyclic AMP; D011494:Protein Kinases; D014357:Trypsin; D000099211:Phospholamban
vernacular_title: Izmeneniia v sisteme cAMP-zavisimogo fosforilirovaniia komponentov sarkoplazmaticheskogo retikuluma miokarda pri tsirkuliatornoĭ gipoksii.