Negative regulation of cyclic-AMP levels by carbamylcholine in dog thyroid is not mediated by cyclic-GMP.
Carbamylcholine, through calcium, enhances cyclic-GMP accumulation and depresses cyclic-AMP accumulation in TSH stimulated dog thyroid. The results presented show that compounds which can be transformed to nitric oxide increase cyclic-GMP accumulation in the dog thyroid. These compounds do not require extracellular calcium for their action. In thyroid stimulated by TSH, these compounds do not depress AMP accumulation. Cyclic-GMP is not the main intracellular signal involved in the negative regulation of cyclic-AMP levels in dog thyroid.
Decoster
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Dumont
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D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D000242:Cyclic AMP / Q000032:analysis*; D006152:Cyclic GMP / Q000502:physiology*; D004285:Dogs; D066298:In Vitro Techniques; D009599:Nitroprusside / Q000494:pharmacology; D013961:Thyroid Gland / Q000032:analysis*; D013972:Thyrotropin / Q000494:pharmacology
D009599:Nitroprusside; D002217:Carbachol; D013972:Thyrotropin; D000242:Cyclic AMP; D006152:Cyclic GMP