title: The effect of ACTH on cerebral blood flow in children with intractable epilepsy.
abstract: Cerebral blood flow was assessed by ultrasound in 12 children with intractable epilepsy who were treated with ACTH. The average maximal blood velocity (A/L) and end-diastolic blood velocity (d) of the internal carotid artery were measured, before, during and after ACTH therapy in each subject. The right and left mean A/L and d values were significantly decreased during ACTH therapy, and these values returned to the previous levels after the treatment. Cerebral function in children treated with ACTH may be affected by a decrease in cerebral blood flow.
authors.forename: Y
authors.initials: Y
authors.lastname: Futagi
authors.forename: J
authors.initials: J
authors.lastname: Abe
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D002343:Carotid Artery, Internal / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D007223:Infant
chemical_list: D000324:Adrenocorticotropic Hormone