Herpes simplex virus latency in a hyperresistant clone of mouse neuroblastoma (Cl300) cells.
Herpes simplex virus (HSV) hyperresistant neuroblastoma cells (clone Cl300 RII) were latently infected with HSV-1 if cultured in presence of HSV-neutralizing antibody for one or two passages after infection and then passaged further without antibody. By superinfecting HSV-1 latently infected Cl300 RII cells with HSV-2, progeny virus with HSV-1 characteristics was regularly rescued. Such retrieval of HSV-1 decreased with passage of the latently infected cells.
Nilheden
E
E
Jeansson
S
S
Vahlne
A
A
D000818:Animals; D000914:Antibodies, Viral; D002460:Cell Line; D002999:Clone Cells; D003470:Culture Media; D005814:Genes, Viral; D051379:Mice; D009447:Neuroblastoma; D009474:Neurons / Q000382:microbiology*; D009500:Neutralization Tests; D018139:Simplexvirus / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D010948:Viral Plaque Assay; D014779:Virus Replication
D000914:Antibodies, Viral; D003470:Culture Media