Changes in metabolism, food and water intake of C3H mice following transplantation of Gardner lymphosarcoma (LSG).
Mice bearing progressing Gardner lymphosarcoma (LSG) increasingly gained in weight in the course of LSG development but their food and water consumption was reduced in comparison with control animals. During the neoplastic growth, oxygen consumption was decreased and the proportion of the metabolically active part (i.e. dried matter) declined. The body weight of tumour-bearing mice successfully cured with methotrexate (MTX) (30 mg/kg body weight, administered on days 1 and 3) was substantially lower than those of non-treated tumourous animals and was similar to that of intact controls. The food and water consumption of mice treated with MTX and that of control animals was similar. Values of the metabolic rate observed in animals treated with MTX were comparable to those recorded in the control group.
Bostík
J
J
Laboratory of Protein Metabolism, Faculty of Medicine, Charles University, Prague.
Vybíral
S
S
Spundová
M
M
D000818:Animals; D001835:Body Weight; D004326:Drinking; D004435:Eating; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D010101:Oxygen Consumption; D013047:Specific Pathogen-Free Organisms