title: In vitro efficacy of sulbactam combined with ampicillin against anaerobic bacteria.
abstract: An ampicillin-sulbactam combination was compared with ampicillin alone, chloramphenicol, clindamycin, and metronidazole against 272 strains of anaerobic bacteria. Chloramphenicol and ampicillin-sulbactam were the most effective, inhibiting 98 to 99% of strains tested at breakpoint (16 micrograms/ml). The combination of sulbactam and ampicillin was much more effective than ampicillin alone against Bacteroides fragilis strains but did not differ substantially from ampicillin alone against Fusobacterium spp., gram-positive rods, and gram-positive cocci.
authors.forename: H M
authors.initials: HM
authors.lastname: Wexler
authors.forename: B
authors.initials: B
authors.lastname: Harris
authors.forename: W T
authors.initials: WT
authors.lastname: Carter
authors.forename: S M
authors.initials: SM
authors.lastname: Finegold
mesh_terms: D000667:Ampicillin / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D004338:Drug Combinations; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000494:pharmacology*; D010403:Penicillin Resistance; D013407:Sulbactam; D065093:beta-Lactamase Inhibitors
chemical_list: D004338:Drug Combinations; D065093:beta-Lactamase Inhibitors; D000667:Ampicillin; D010397:Penicillanic Acid; D013407:Sulbactam