Suppressive effect of cyclosporin A on the induction of chronic serum sickness nephritis in the rat.
The suppressive effect of cyclosporin A (CyA) on the development of antibody-induced glomerulonephritis was analyzed in rats with serum sickness nephritis. The induction of serum sickness was established by preimmunization and subsequent continuous administration of the same antigen starting 1 month later. When CyA was given in the preimmunization stage, neither induction of glomerulonephritis nor specific antibody response was observed. In contrast, when CyA was administered in the stage of continuous sensitization, mild glomerulonephritis as well as specific antibody response developed. This phenomenon implies that the significant inhibition of the occurrence of immune complex nephritis results from the suppression by CyA of its primary response to the sensitizing antigen.
Shigematsu
H
H
Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan.
Koyama
A
A
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002908:Chronic Disease; D003524:Cyclosporins / Q000008:administration & dosage / Q000494:pharmacology*; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology; D007105:Immune Complex Diseases / Q000276:immunology* / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D003524:Cyclosporins