title: The 'metabolic burst' in polymorphonuclear leukocytes from patients with quiescent psoriasis.
abstract: We report an investigation of peripheral blood polymorphonuclear leukocytes (PMN) from untreated patients with mild, quiescent psoriasis. Four aspects of the 'metabolic burst' were measured to illustrate phagocytosis-related events. These were: myeloperoxidase activity, hydrogen peroxide release, superoxide production and luminol-amplified chemiluminescence. Our study does not support the concept of an intrinsic abnormality of the PMN in psoriasis, but provides additional evidence for disease activity-dependent changes in phagocytic behaviour. Possible interactions with certain humoral factors, the so-called opsonins, are discussed.
authors.forename: J P
authors.initials: JP
authors.lastname: Geerdink
authors.forename: P W
authors.initials: PW
authors.lastname: Troost
authors.forename: J
authors.initials: J
authors.lastname: Schalkwijk
authors.forename: L A
authors.initials: LA
authors.lastname: Joosten
authors.forename: P D
authors.initials: PD
authors.lastname: Mier
mesh_terms: D000328:Adult; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D008163:Luminescent Measurements; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology / Q000378:metabolism*; D009195:Peroxidase / Q000097:blood; D011565:Psoriasis / Q000097:blood* / Q000201:enzymology; D013481:Superoxides / Q000097:blood
chemical_list: D013481:Superoxides; D006861:Hydrogen Peroxide; D009195:Peroxidase