[Participation of beta-endorphin in the regulation of the membrane chemoreactive properties of the cortical neurons in rats].
The subcutaneous administration of beta-endorphin and its endogenic accumulation in the process of elaboration of adaptation to the short-term stress influences is accompanied by the change of chemoreactive properties of rat sensorimotor cortex neurons expressed in increasing of the share of areactive cells and lowering of the share of cells reacting by the response activational form to acetylcholine and noradrenaline led to them microiontophoretically. The reaction intensity of cells, both activational and inhibitory forms to the led neurotransmitters in both experimental groups is significantly lower than in control. The revealed changes of chemoreactive properties of neurons, arising under the influence of the increase of beta-endorphin amount in brain may be one of the mechanisms of its participation in the processes of learning and memory.
Kruglikov
R I
RI
Antipina
M Iu
MIu
Koshtoiants
O Kh
OKh
D000109:Acetylcholine / Q000008:administration & dosage; D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D007478:Iontophoresis; D008839:Microelectrodes; D009044:Motor Cortex / Q000187:drug effects / Q000502:physiology*; D009433:Neural Inhibition / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000008:administration & dosage; D051381:Rats; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000503:physiopathology; D013997:Time Factors; D001615:beta-Endorphin / Q000494:pharmacology / Q000502:physiology*
D001615:beta-Endorphin; D000109:Acetylcholine; D009638:Norepinephrine
Uchastie beta-éndofina v reguliatsii khemoreaktivnykh svoĭstv membran kortikal'nykh neĭronov krys.