title: Low dose infusion of atrial natriuretic peptide causes salt and water excretion in normal man.
abstract: 1. The effects of low dose infusion of atrial natriuretic peptide (ANP) were observed in double-blind, placebo-controlled study in six fluid-loaded volunteers. After baseline observations, hourly increments of 0.4, 2 and 10 pmol min-1 kg-1 were infused with continuous observation of heart rate, blood pressure and cardiac output. Plasma ANP, aldosterone, and catecholamines, and urinary volume and sodium excretion, were estimated at half-hourly intervals. 2. ANP infusion resulted in an increase of 35, 98 and 207% in urinary sodium excretion and of 10, 20 and 71% in urinary volume when compared with placebo. Plasma ANP was markedly elevated above placebo levels only during infusion of 10 pmol of ANP min-1 kg-1. 3. No change in heart rate of blood pressure was noted during the study, but a significant fall in stroke volume index was observed during active treatment. Plasma levels of aldosterone and catecholamines were not significantly different on the 2 treatment days. 4. The potent natriuretic and diuretic effects of this peptide at plasma concentrations not significantly elevated from physiological suggest a hormonal role for ANP in the homoeostasis of salt and water balance.
authors.affiliation: Clinical Pharmacology Unit, Addenbrooke's Hospital, Cambridge, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Morice
authors.forename: J
authors.initials: J
authors.lastname: Pepke-Zaba
authors.forename: E
authors.initials: E
authors.lastname: Loysen
authors.forename: R
authors.initials: R
authors.lastname: Lapworth
authors.forename: M
authors.initials: M
authors.lastname: Ashby
authors.forename: T
authors.initials: T
authors.lastname: Higenbottam
authors.forename: M
authors.initials: M
authors.lastname: Brown
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects*; D004311:Double-Blind Method; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009318:Natriuresis / Q000187:drug effects
chemical_list: D000450:Aldosterone; D009320:Atrial Natriuretic Factor