Peripheral neuropathy during longterm high-dose amiodarone therapy.
Three patients developed peripheral neuropathy after taking amiodarone for more than 18 months. All had high serum concentrations of amiodarone and its desethyl metabolite; in one patient concentrations in a sural nerve biopsy were 80 times higher than in serum. Peripheral neuropathy is a complication of large doses of amiodarone taken over long periods.
Fraser
A G
AG
McQueen
I N
IN
Watt
A H
AH
Stephens
M R
MR
D000368:Aged; D000638:Amiodarone / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000097:blood; D001572:Benzofurans / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*
D001572:Benzofurans; C036116:desethylamiodarone; D000638:Amiodarone