[Isoproterenol stimulation of the repair of single-stranded DNA breaks in Chinese hamster cells induced by gamma irradiation].
The action of the increased intracellular content of adenosine monophosphate (cAMP) in CHO-K1 cells (clones 773 and ADr112eb), treated with isoproterenol, on gamma-induced DNA single-strand breaks repair has been investigated. The hormonal treatment stimulates gamma-induced (180 Gr) DNA single-strand repair during the post-irradiation incubation (45 min) by 75 +/- 16%. The results show the involvement of the cAMP system in radiosensitivity of cultured mammalian cells and in regulation of cellular mechanisms of DNA repair.
Vikhanskaia
F L
FL
Efimova
E V
EV
Zhestianikov
V D
VD
D000818:Animals; D002999:Clone Cells / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D000242:Cyclic AMP / Q000378:metabolism / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D004277:DNA, Single-Stranded / Q000528:radiation effects*; D005720:Gamma Rays; D007545:Isoproterenol / Q000494:pharmacology*; D011836:Radiation Tolerance; D013268:Stimulation, Chemical
D004277:DNA, Single-Stranded; D000242:Cyclic AMP; D007545:Isoproterenol
Stimuliatsiia izoproterenolom reparatsii odnonitevykh razryvov DNK v kletkakh kitaĭskogo khomiachka, indutsirovannykh gamma-oblucheniem.