title: Acyclic pyrimidine nucleoside analogues: influence on growth of L5178y mouse lymphoma cells and antiherpes activity in KB cells.
abstract: Several uracil and cytosine nucleoside analogues with 2-hydroxyethoxymethyl, 2-aminoethoxymethyl or 1,3-dihydroxypropoxymethyl side chains were synthesized and evaluated for cytostatic (L5178y mouse lymphoma cells) and antiviral (herpes simplex virus type 1 infected KB cells) activity. Two compounds exhibited antiherpesvirus activity. These were 1-(2'-hydroxyethoxymethyl)-5-aza-cytosine and 1-(1',3'-dihydroxypropoxymethyl)-5-iodouracil. The MIC values were 25.8 and 325.7 micrograms/ml, respectively.
authors.forename: L B
authors.initials: LB
authors.lastname: Allen
authors.forename: H C
authors.initials: HC
authors.lastname: Schröder
authors.forename: R K
authors.initials: RK
authors.lastname: Zahn
authors.forename: P
authors.initials: P
authors.lastname: Stoss
authors.forename: A
authors.initials: A
authors.lastname: Maidhof
authors.forename: W E
authors.initials: WE
authors.lastname: Müller
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D000998:Antiviral Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D007624:KB Cells; D008223:Lymphoma / Q000473:pathology*; D051379:Mice; D011741:Pyrimidine Nucleosides / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D011741:Pyrimidine Nucleosides