title: Simultaneous application of live turkey herpesvirus and infectious bursal disease vaccines against Marek's disease and infectious bursal disease.
abstract: The efficacy of cell-associated (CA) and cell-free (CF) infectious bursal disease (IBD) vaccines in maternal antibody (MAb)-bearing broiler chickens was compared. Compatibility and potency of a mixed vaccine combining live CA turkey herpesvirus (HVT) and CA IBD vaccine viruses were also tested against gross lesions induced by Marek's disease (MD) or IBD in specific-pathogen-free chickens. Both CA and CF IBD vaccines provided significant protection against gross bursal lesions of IBD in the presence of MAb. Although chickens receiving the CA vaccine showed a slightly higher (60 to 86.7%) protective index (PX) than CF vaccine recipients (40 to 66.7%), there was no statistical difference in their PX between comparable CA and CF IBD vaccines. The HVT and IBD virus (IBDV) were compatible when they were combined as a live bivalent mixed HVT-IBDV vaccine. Based on the incidence of gross lesions induced by challenge exposure to MD or IBD, potency of the mixed vaccine was similar to that of the monovalent HVT or IBD vaccine. Antagonism did not occur between the two component vaccines when they were applied simultaneously.
authors.forename: J D
authors.initials: JD
authors.lastname: Chang
authors.forename: C S
authors.initials: CS
authors.lastname: Eidson
authors.forename: S H
authors.initials: SH
authors.lastname: Kleven
mesh_terms: D000818:Animals; D002645:Chickens; D006564:Herpesviridae / Q000276:immunology*; D007243:Infectious bursal disease virus / Q000276:immunology*; D008380:Marek Disease / Q000517:prevention & control*; D012087:Reoviridae / Q000276:immunology*; D012088:Reoviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D014422:Turkeys / Q000382:microbiology; D014611:Vaccination / Q000662:veterinary; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines