Abnormality of helper/suppressor T cell ratio in patients with hemophilia.
Lymphocyte subpopulations in patients with hemophilia were analyzed. The results were compared with those in age- and sex-matched controls. The patients had been receiving blood and blood products including Factor VIII or Factor IX for a number of years as required at the time of the onset of the disease. Heparinized peripheral blood was used in direct tests for cell marker analysis with OKT4, OKT8 and OKT11 monoclonal antibodies. There were less OKT4+ cells in the hemophiliac blood as compared with the controls, while both the groups had the same number of OKT8+ cells. As a result, the OKT4/OKT8 ratio was markedly depressed in the hemophiliac group and the conversion of the OKT4/OKT8 ratio was observed in the group of patients receiving long-term therapy with anti-hemophiliac products. Alteration of lymphocyte subpopulations in patients with hemophilia in relation to antihemophiliac therapy was discussed.
Yasuda
K
K
Matsumoto
K
K
Okubo
K
K
Yokoyama
M M
MM
Hiyoshi
Y
Y
Natori
H
H
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000293:Adolescent; D000914:Antibodies, Viral; D002648:Child; D002675:Child, Preschool; D017977:Deltaretrovirus / Q000276:immunology; D005260:Female; D006467:Hemophilia A / Q000097:blood / Q000276:immunology*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000914:Antibodies, Viral