[Structure and distribution of RU 41740].
RU 41740 is obtained from Klebsiella pneumoniae by organic extraction. It is mainly composed of carbohydrates with a small portion of proteins. Its active principle consists of two repetitive glyco-protein subunits: P1 which has a relative molecular mass of 95 kD and comes from the bacterial capsule, and F1 (relative molecular mass 350 kD) which is issued from the external bacterial membrane. Animal studies performed with tritiated RU 41740 have shown that the compound crosses the intestinal wall and that it rapidly and preferentially enters the lymphatic system. After oral administration to mice, the drug is detected by immunofluorescence in the basal end of the cells and chorion of the digestive tract epithelium.
Chaumet
B
B
Laboratoire de Physiologie, Faculté Necker-Enfants malades, Paris.
Boissier
M C
MC
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D055598:Chemical Phenomena; D002621:Chemistry; D007408:Intestinal Absorption; D051379:Mice; D051381:Rats
D000276:Adjuvants, Immunologic; D001426:Bacterial Proteins; C037567:glycoprotein, Klebsiella pneumoniae
Structure et distribution du RU 41740.