title: Acquired immune deficiency syndrome. Pathogenic mechanisms of ocular disease.
abstract: A gross, light, and electron microscopic study of the eyes from 35 consecutive autopsy cases of the acquired immune deficiency syndrome revealed cotton-wool spots (71% of cases), retinal hemorrhage in areas without cytomegalovirus infection (40%), cytomegalovirus retinitis (34%) with associated retinal detachment, Roth's spots (23%), retinal microaneurysms (20%), papilledema (14%), conjunctival Kaposi's sarcoma (9%), cryptococcal chorioretinitis (6%), Mycobacterium avium-intracellulare in retina and in choroidal granulomas (6%), ischemic maculopathy (6%), bilateral keratitis (3%), and herpes simplex retinitis (3%). Ocular infection with candida or toxoplasmosis were not found in this autopsy series. Immunocytologic studies demonstrated deposition of immunoglobulins in arteriolar walls, consistent with immune complex mediated disease. Ultrastructural studies showed a vasculopathy in the areas near cotton-wool spots. A mechanism is proposed linking the deposition of immune complexes with subsequent small vessel lesions, ischemia, cotton-wool spots and later spread of cytomegalovirus to retina via damaged vascular endothelium.
authors.forename: J S
authors.initials: JS
authors.lastname: Pepose
authors.forename: G N
authors.initials: GN
authors.lastname: Holland
authors.forename: M S
authors.initials: MS
authors.lastname: Nestor
authors.forename: A J
authors.initials: AJ
authors.lastname: Cochran
authors.forename: R Y
authors.initials: RY
authors.lastname: Foos
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology* / Q000503:physiopathology; D000328:Adult; D001424:Bacterial Infections / Q000453:epidemiology; D002196:Capillaries / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000473:pathology; D003586:Cytomegalovirus Infections / Q000473:pathology; D005128:Eye Diseases / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007105:Immune Complex Diseases / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012173:Retinitis / Q000473:pathology; D012514:Sarcoma, Kaposi / Q000473:pathology; D014777:Virus Diseases / Q000453:epidemiology