Antitumor effect of lipiodolized doxorubicin on VX2 carcinoma in rabbits.
Twelve-day-old VX2 carcinoma was inoculated in the hind leg of 24 rabbits and, after 12 days, Doxorubicin (Adriamycin) suspended in Lipiodol Ultra-Fluid (Lipiodol) was then given through the femoral artery. A selective deposit of the contrast material in the tumor for an extended time was evident on the x-rays and the antitumorous effect was remarkable. Lipiodolized antitumor agents warrant further investigation for possible clinical application.
Furuta
T
T
Kanematsu
T
T
Ezaki
T
T
Sugimachi
K
K
Inokuchi
K
K
D000818:Animals; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000008:administration & dosage*; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D007459:Iodized Oil / Q000008:administration & dosage*; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D011817:Rabbits
D004338:Drug Combinations; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D007459:Iodized Oil; D004317:Doxorubicin