Local blood-brain barrier penetration following systemic contrast medium administration. A case report and an experimental study.
The present study was initiated by a severe complication in a patient with renal dysfunction who developed cortical blindness and weakness of her left extremities 30 hours following renal and abdominal angiography. To evaluate the impact of prolonged high serum concentrations of contrast medium (CM) this clinical situation was simulated in a laboratory model using sheep with elevated serum levels of contrast medium maintained for 48 hours. The experimental data did not support the theory that the prolonged exposure to high circulating levels of contrast medium (4 ml/kg body weight of meglumine diatrizoate 60%) is sufficient alone to cause penetration of the blood-brain barrier.
Utz
R
R
Department of Diagnostic Radiology, University of Rochester Medical Center, New York 14642.
Ekholm
S E
SE
Isaac
L
L
Sands
M
M
Fonte
D
D
D000368:Aged; D000792:Angiography / Q000009:adverse effects; D000818:Animals; D001002:Anuria / Q000503:physiopathology; D001812:Blood-Brain Barrier; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects*; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging; D003974:Diatrizoate Meglumine / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D012756:Sheep; D014057:Tomography, X-Ray Computed
D003974:Diatrizoate Meglumine