Ability of monophosphoryl lipid A to augment the antibody response of young mice.
Treatment with nontoxic monophosphoryl lipid A increased the magnitude of the immunoglobulin M (IgM) antibody response to type III pneumococcal polysaccharide in young (2- to 4-week-old) mice. This was accompanied by the appearance of significant numbers of IgG1- and IgG3- secreting antibody-forming cells in 4-week-old mice. These findings indicate that monophosphoryl lipid A can be used as an adjuvant to improve the immunogenicity of poorly immunogenic antigens in young, immunologically immature animals.
Baker
P J
PJ
Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Hiernaux
J R
JR
Fauntleroy
M B
MB
Stashak
P W
PW
Prescott
B
B
Cantrell
J L
JL
Rudbach
J A
JA
D000276:Adjuvants, Immunologic; D000367:Age Factors; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000917:Antibody Formation; D007075:Immunoglobulin M / Q000096:biosynthesis; D008050:Lipid A / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D007075:Immunoglobulin M; D008050:Lipid A; D011135:Polysaccharides, Bacterial; C048436:monophosphoryl lipid A