title: Biochemical basis of muscular fatigue associated with repetitious contractions of skeletal muscle.
abstract: The decline in force generating capabilities of skeletal muscle associated with prolonged, repetitive low force producing contractions does have a biochemical basis. It is our view that an alteration in neuromuscular transmission results in an uncoupling of excitation-contraction via disturbances in Ca2+ imbalance, an uncoupling of energy utilization and production may result, which affect a favourable cellular environment for the initiation of myofilament degradation. The myofilament dissolution may be the last stage in this fatigue process and associated with only extreme conditions of muscle use.
authors.forename: A N
authors.initials: AN
authors.lastname: Belcastro
authors.forename: I
authors.initials: I
authors.lastname: Maclean
authors.forename: J
authors.initials: J
authors.lastname: Gilchrist
mesh_terms: D000200:Action Potentials; D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000502:physiology; D000252:Calcium-Transporting ATPases / Q000502:physiology; D002463:Cell Membrane Permeability; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009119:Muscle Contraction; D009132:Muscles / Q000502:physiology* / Q000648:ultrastructure; D009210:Myofibrils / Q000201:enzymology; D009469:Neuromuscular Junction / Q000502:physiology; D005082:Physical Exertion; D011189:Potassium Chloride / Q000494:pharmacology; D012519:Sarcoplasmic Reticulum / Q000502:physiology; D009435:Synaptic Transmission
chemical_list: D011189:Potassium Chloride; D000252:Calcium-Transporting ATPases; D002118:Calcium