Immunological effect of silica dust analyzed by monoclonal antibodies.
We found a significant decrease of OKT8 + ve cells in silicosis patients (18.1%), but also in unaffected exposed workers (19.0%), when compared with sex- and age-matched controls (22.8%). The proportion of OKT8 + ve cells was significantly lower in subjects with antinuclear antibodies (15.7%) and in those with IgG-rheumatoid factors (16.3%).
Youinou
P
P
Ferec
C
C
Cledes
J
J
Zabbe
C
C
Philippon
P
P
Dewitte
J D
JD
Guillerm
D
D
Clavier
J
J
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000032:analysis; D001323:Autoantibodies / Q000276:immunology; D004391:Dust; D006801:Humans; D008297:Male; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000032:analysis; D012822:Silicon Dioxide; D012829:Silicosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
D000974:Antibodies, Antinuclear; D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D001323:Autoantibodies; D004391:Dust; D012822:Silicon Dioxide; D012217:Rheumatoid Factor