Comparison of cicletanine with other antihypertensive drugs in SHR-SP models.
The effects of cicletanine were compared with those of four other antihypertensive drugs (prazosin, a highly selective alpha 1 antagonist; captopril, an angiotensin-converting enzyme inhibitor; indapamide, an antihypertensive diuretic; and hydrochlorothiazide, a purely diuretic agent) on young stroke-prone SHR rats with high-salt diet. All the drugs except hydrochlorothiazide prevented the onset of hypertension. The minimal effective dose on blood pressure was 1 mg/kg for both cicletanine and captopril, and 3 mg/kg for indapamide. The action on cardiac hypertrophy and diuresis occurs at a dose of cicletanine 10 to 30 times higher than that required to produce the antihypertensive effect. Renal hypertrophy was also decreased significantly by cicletanine at a dose of 100 mg/kg.
Malherbe
E
E
Henri Beaufour Institute, Le Plessis-Robinson, France.
Le Hegarat
M
M
Clostre
F
F
Braquet
P
P
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology; D006332:Cardiomegaly / Q000517:prevention & control; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004573:Electrolytes / Q000652:urine; D006852:Hydrochlorothiazide / Q000494:pharmacology; D006973:Hypertension / Q000188:drug therapy*; D006984:Hypertrophy; D007190:Indapamide / Q000494:pharmacology; D007668:Kidney / Q000473:pathology; D008297:Male; D011224:Prazosin / Q000494:pharmacology*; D011725:Pyridines; D051381:Rats; D011918:Rats, Inbred SHR
D000959:Antihypertensive Agents; D004232:Diuretics; D004573:Electrolytes; D011725:Pyridines; D006852:Hydrochlorothiazide; D002216:Captopril; C038068:cicletanine; D007190:Indapamide; D011224:Prazosin