[Innate forms of behavior and energy metabolism in the brain of the rat after phenazepam administration in the presence of inescapable painful stimulation].
Initially low level of motor search activity in test situations ("open field", maze) in rats previously grouped according to their passive behaviour with a partner-victim (Simonov method), does not essentially change after 3-week administration of phenazepam; the activity level of cytochrome oxidase in the cortex and hypothalamus is lowered. Phenazepam administration in conditions of prolonged unavoidable painful stimulation brings to a sharp increase of motor search activity and aggressive behaviour. Simultaneously the cytochrome oxidase activity increases in the same way as during a stress without phenazepam. This fact points to the independence of behavioural and biochemical effects in this case.
Khonicheva
N M
NM
Guliaeva
N V
NV
Gorbach
A M
AM
D000374:Aggression / Q000502:physiology; D000818:Animals; D014151:Anti-Anxiety Agents; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use*; D001921:Brain / Q000201:enzymology*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D005106:Exploratory Behavior / Q000502:physiology; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology; D010146:Pain / Q000503:physiopathology; D051381:Rats; D013312:Stress, Physiological / Q000188:drug therapy* / Q000503:physiopathology
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D003576:Electron Transport Complex IV
Vrozhdennye formy povedeniia i énergeticheskiĭ obmen v golovnom mozge krys pri vvedenii fenazepama v usloviiakh neizbegaemogo bolevogo razdrazheniia.