Effect of trazodone on oxidative metabolism of rat brain in vitro.
Oxygen uptake of rat brain homogenate was reduced by 1 mM trazodone, a new atypical antidepressant. Na,K-ATPase activity and the associated oxygen consumption of rat brain slices were also reduced. Oxygen consumption of rat brain slices was enhanced by dopamine and this effect was blocked by 0.0001 mM trazodone. This drug uncoupled oxidative phosphorylation.
Velasco
A
A
González-Calvo
V
V
Alvarez
F J
FJ
Dueñas
A
A
García-Roldán
J L
JL
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D004298:Dopamine / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014196:Trazodone / Q000494:pharmacology*
D010879:Piperazines; D000254:Sodium-Potassium-Exchanging ATPase; D005947:Glucose; D004298:Dopamine; D014196:Trazodone