title: A region of the Herpesvirus saimiri genome required for oncogenicity.
abstract: Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.
authors.forename: R C
authors.initials: RC
authors.lastname: Desrosiers
authors.forename: A
authors.initials: A
authors.lastname: Bakker
authors.forename: J
authors.initials: J
authors.lastname: Kamine
authors.forename: L A
authors.initials: LA
authors.lastname: Falk
authors.forename: R D
authors.initials: RD
authors.lastname: Hunt
authors.forename: N W
authors.initials: NW
authors.lastname: King
mesh_terms: D000818:Animals; D001029:Aotus trivirgatus; D004274:DNA, Recombinant / Q000378:metabolism; D004279:DNA, Viral / Q000235:genetics; D005814:Genes, Viral; D006566:Herpesviridae Infections / Q000235:genetics; D006567:Herpesvirus 2, Saimiriine / Q000235:genetics*; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000382:microbiology; D009857:Oncogenes; D014412:Tumor Virus Infections / Q000235:genetics
chemical_list: D004274:DNA, Recombinant; D004279:DNA, Viral