title: Malignant fibrous histiocytoma of soft tissue. An analysis of 78 cases located and deeply seated in the extremities.
abstract: Seventy-eight cases of malignant fibrous histiocytoma (MFH) of soft tissues are reported. All tumors were deeply located in the extremities. An analysis is presented with regard to sex, age, site, macro- and microscopic features. The staging was assessed according to Enneking's classification (IB, one case; IIA, 25 cases; IIB, 42 cases; III, 10 cases). The recurrence rate after surgical treatment was high (37.5%) with significant differences after inadequate surgery (70%), wide excision (38%), or amputation (0%). Adjunctive radiotherapy rarely was effective in preventing local recurrence. The overall 5-year survival rate was 36%. The prognosis was worse in (1) tumors larger than 5 cm in diameter, (2) tumors that recurred early (less than 1 year) after surgery, and (3) tumors that had inadequate surgical treatment (intralesional or marginal excision).
authors.forename: F
authors.initials: F
authors.lastname: Bertoni
authors.forename: R
authors.initials: R
authors.lastname: Capanna
authors.forename: R
authors.initials: R
authors.lastname: Biagini
authors.forename: P
authors.initials: P
authors.lastname: Bacchini
authors.forename: A
authors.initials: A
authors.lastname: Guerra
authors.forename: P
authors.initials: P
authors.lastname: Ruggieri
authors.forename: D
authors.initials: D
authors.lastname: Present
authors.forename: M
authors.initials: M
authors.lastname: Campanacci
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003131:Combined Modality Therapy; D005121:Extremities / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D018219:Histiocytoma, Benign Fibrous / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011859:Radiography; D012189:Retrospective Studies