Study of the antagonism between zinc and various embryonic toxics on human amnion permeability. I. Zinc and cadmium.
The effects of Cd and Zn have been studied on the ionic permeation of the isolated human amnion, expressed by the measure of the transamniotic conductance Gt and the flux ratio (mother-fetus/fetus-mother: F1/F2). Cd has no action on Gt on the fetal side and decreases Gt on the maternal side by a screening effect. Zn acts on the two faces by a screening-binding effect. The ratio F1/F2 remains constant with Zn concentration, but decreases with Cd and becomes less than 1 at 5 mmol/l of Cd. F1/F2 decreases with the duration of the administration of Cd. Zn has the opposite effect of Cd on the ionic transfer and has a stabilizing action on the amnion. Moreover, Zn may antagonize the noxious effect of Cd on the maternal side.
Bara
M
M
Laboratory of Biology of Reproduction, University P.M. Curie, Paris, France.
Guiet-Bara
A
A
Durlach
J
J
D000650:Amnion / Q000187:drug effects* / Q000378:metabolism; D002104:Cadmium / Q000493:pharmacokinetics*; D002105:Cadmium Poisoning / Q000378:metabolism*; D004553:Electric Conductivity; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D010539:Permeability / Q000187:drug effects; D011247:Pregnancy; D015032:Zinc / Q000037:antagonists & inhibitors* / Q000493:pharmacokinetics
D002104:Cadmium; D015032:Zinc