Experimental candidiasis associated with liver injury. Role of transferrin.
In an attempt to perform a further investigation on the proposal that an increasing susceptibility to Candida infection in liver injury may be related to unsaturated transferrin level (UIBC) and/or to a total amount of transferrin represented by TIBC, we conducted experimental candidiasis using mice with galactosamine-induced liver injury and investigated the effect of preadministration of transferrin prior to inoculation of Candida albicans. Final mortality was 10% in the mice without liver injury and without transferrin (Group 1) and ones with liver injury and with transferrin (Group 3). By contrast a 50% mortality was given in one only with liver injury (Group 2). The TIBCs in Groups 1 and 3 were significantly higher than that in Group 2. The UIBCs in Groups 2 and 3, although there was no significant difference between them, were significantly lower than that in Group 1. This study confirmed that transferrin (TIBC) may have a direct deterring effect on systemic Candida infection and the decreased TIBC in the liver injury enhances the growth of C. albicans.
Abe
F
F
Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan.
Katoh
T
T
Inaba
H
H
Hotchi
M
M
D000818:Animals; D001921:Brain / Q000382:microbiology; D002176:Candida albicans / Q000254:growth & development; D002177:Candidiasis / Q000097:blood / Q000209:etiology* / Q000382:microbiology; D056486:Chemical and Drug Induced Liver Injury; D007501:Iron / Q000097:blood; D007668:Kidney / Q000382:microbiology; D008107:Liver Diseases / Q000150:complications*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013047:Specific Pathogen-Free Organisms; D014168:Transferrin / Q000032:analysis / Q000502:physiology*
D014168:Transferrin; D007501:Iron