[Effect of nicotinic acid, nicotinamide and its combination with ziksorin and phenobarbital on the UDP glucuronyl transferase activity of the hepatic endoplasmic reticulum in the rat].
Nicotinic acid and nicotinamide (100 mg/kg) increase the activity of the rat liver microsomal uridine diphosphate-glucuronyltransferase by 55 and 73.8%. Administration of nicotinamide in combination with ziksorin or phenobarbital enhanced the enzyme-inducing effects of the latter.
Legon'kova
L F
LF
Lukienko
P I
PI
Bushma
M I
MI
D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000201:enzymology; D004790:Enzyme Induction / Q000187:drug effects; D014453:Glucuronosyltransferase / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009525:Niacin / Q000494:pharmacology*; D009536:Niacinamide / Q000494:pharmacology*; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats
D001559:Benzhydryl Compounds; D009536:Niacinamide; D009525:Niacin; D014453:Glucuronosyltransferase; C016914:flumecinol; D010634:Phenobarbital
Vliianie nikotinovoĭ kisloty, nikotinamida i ego kombinatsii s ziksorinom i fenobarbitalom na aktivnost' UDF-gliukuroniltransferazy éndoplazmaticheskogo retikuluma pecheni krys.