title: Prenatal chlordiazepoxide effects on metrazol seizures and benzodiazepine receptors density in adult albino rats.
abstract: Adult offsprings of rats treated with daily injection of chlordiazepoxide (10 mg/kg, i.p.) during pregnancy showed a significant decrease in benzodiazepine receptors in the cortex and the cerebellum without apparent changes in receptor affinity. A reduced susceptibility to metrazol-induced epileptogenesis paralleled this change. These findings are discussed in relation to the differential vulnerability of various types of benzodiazepine receptors.
authors.forename: M
authors.initials: M
authors.lastname: Gavish
authors.forename: N
authors.initials: N
authors.lastname: Avnimelech-Gigus
authors.forename: J
authors.initials: J
authors.lastname: Feldon
authors.forename: M
authors.initials: M
authors.lastname: Myslobodsky
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000196:embryology / Q000378:metabolism; D002531:Cerebellum / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004351:Drug Resistance; D005260:Female; D005445:Flunitrazepam / Q000378:metabolism; D010433:Pentylenetetrazole; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects*; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D011963:Receptors, GABA-A; D005445:Flunitrazepam; D002707:Chlordiazepoxide; D010433:Pentylenetetrazole