title: Phenotypic expression of B lymphocytes. III. Marginal zone B cells in the spleen are characterized by the expression of Tac and alkaline phosphatase.
abstract: The marginal zone of the spleen contains lymphocytes with an intermediate morphologic form between small lymphocytes and plasmablasts. The majority of cells can be stained by B cell monoclonal antibodies including B1, Leu-14, and Leu-12. The most significant finding is the expression of an interleukin 2 receptor (Tac) and an enzyme-alkaline phosphatase by the marginal zone B lymphocytes. The Tac antigen is not normally present in B cells, but can be found in a portion of in vitro-activated B lymphocytes. In conjunction with other evidence, the marginal zone B lymphocytes may represent the activated B cells in the early stages of B cells differentiation. Alternatively, the Tac-positive, marginal zone B lymphocytes may be a discrete subpopulation of activated B cells.
authors.forename: S M
authors.initials: SM
authors.lastname: Hsu
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis*; D000818:Animals; D000944:Antigens, Differentiation, B-Lymphocyte; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis*; D001402:B-Lymphocytes / Q000145:classification* / Q000201:enzymology / Q000276:immunology; D006801:Humans; D007072:Immunoglobulin D / Q000032:analysis; D008562:Membrane Glycoproteins; D051379:Mice; D010641:Phenotype; D011817:Rabbits; D013154:Spleen / Q000032:analysis / Q000166:cytology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7
chemical_list: D000944:Antigens, Differentiation, B-Lymphocyte; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D007072:Immunoglobulin D; D008562:Membrane Glycoproteins; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; C028388:thymus-leukemia antigens; D000469:Alkaline Phosphatase