title: Cholecalciferol metabolites in polycythemic newborns.
abstract: Metabolites of cholecalciferol were measured in the sera of healthy and polycythemic newborns at 15.5 and 10.5 h of age (median), respectively. The serum concentrations of 1,25-dihydroxyvitamin D and 24,25-dihydroxyvitamin D were lower in the polycythemic group (P less than 0.003 and P less than 0.001, respectively). As the kidney is the main site of conversion of 25-hydroxyvitamin D to its dihydroxylated metabolites, it is possible that hyperviscosity and subsequent decrease in renal blood flow interfere with the efficiency of the process.
authors.forename: A
authors.initials: A
authors.lastname: Alkalay
authors.forename: J J
authors.initials: JJ
authors.lastname: Pomerance
authors.forename: J
authors.initials: J
authors.lastname: Prause
authors.forename: B M
authors.initials: BM
authors.lastname: Mogilner
authors.forename: S
authors.initials: S
authors.lastname: Edelstein
mesh_terms: D015650:24,25-Dihydroxyvitamin D 3; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood; D002762:Cholecalciferol / Q000378:metabolism*; D004100:Dihydroxycholecalciferols / Q000097:blood; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood*; D007231:Infant, Newborn; D011086:Polycythemia / Q000097:blood / Q000378:metabolism*
chemical_list: D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D002762:Cholecalciferol; D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol; D002112:Calcifediol