[Effect of adrenaline on the mitosis-inhibiting action of a chalone-containing preparation in Ehrlich ascites tumor].
The effect of adrenaline and Ehrlich ascite carcinoma (EAC) chalone on cell division was studied. It has been established that EAC chalone inhibited cell proliferation. The action of adrenaline was also accompanied by a decrease in mitotic index, but the inhibitory effect of the hormone was weaker than that of chalone, it occurred later and its duration was less. A combined effect of adrenaline and chalone depended on the time interval between the administration of the substances. It has been found that chalone administration 1 h after adrenaline administration prolonged mitotic inhibitory effect by 4 h and its synchronous action on cell division in EAC was weak during the experiment. Combined effect of adrenaline and chalone did not differ from the effect of chalone alone if chalone was administered 3 h after adrenaline administration.
Romanov
Iu A
IuA
Ivchenko
T N
TN
Sultanova
Z F
ZF
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002286:Carcinoma, Ehrlich Tumor / Q000503:physiopathology*; D002455:Cell Division / Q000187:drug effects; D003864:Depression, Chemical; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D013997:Time Factors
D006131:Growth Inhibitors; D004837:Epinephrine
Vliianie adrenalina na ingibiruiushchee mitoz deĭstvie keĭlonsoderzhashchego preparata v astsitnoĭ opukholi Erlikha.