title: A comparative study of the effect of cimetidine and ranitidine on the rate of gastric emptying of liquid and solid test meals in man.
abstract: Paired studies were carried out on 18 healthy male volunteers (20.9 +/- 1.9 years; mean +/- S.D.) to compare the effect of oral doses of the H2-receptor antagonists, ranitidine and cimetidine, on the rate of gastric emptying of radiolabelled solid and liquid test meals. Oral administration of ranitidine 300 mg accelerated the emptying of a liquid meal from the stomach, but it had no significant effect on the rate of emptying of a solid meal. Oral administration of either 400 or 800 mg cimetidine did not alter the rate of emptying of either the liquid or the solid meals from the stomach.
authors.affiliation: Sub-department of Human Gastrointestinal Physiology and Nutrition, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: L A
authors.initials: LA
authors.lastname: Houghton
authors.forename: N W
authors.initials: NW
authors.lastname: Read
mesh_terms: D000293:Adolescent; D000328:Adult; D002927:Cimetidine / Q000494:pharmacology*; D004311:Double-Blind Method; D005502:Food; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D011899:Ranitidine / Q000494:pharmacology*
chemical_list: D002927:Cimetidine; D011899:Ranitidine