title: Capacity of B-lymphocytic lines of diverse tumor origin to produce and respond to B-cell growth factors: a progression model for B-cell lymphomagenesis.
abstract: Human cell lines established from cases of acute lymphoblastic leukemia, lymphosarcoma, Burkitt's lymphoma and multiple myeloma and representing stages of B-lymphocyte development ranging from pre-B through to plasma cells, were assessed for their ability to produce and respond to B-cell growth factors (BCGF). All B-cell lines studied were found to be constitutive producers of a growth activity which assisted the S-phase entry of normal activated B-cells and provided growth support for lymphoblastoid cells transformed by Epstein-Barr virus. Furthermore, all lines responded by enhanced proliferation to supernatants from a BCGF-producing T-cell hybridoma. Not all lines, however, displayed autostimulation to their own supernatants and no tumor B-cell line appeared totally dependent on soluble factors for its growth. Non-tumorigenic B-cell lines, by contrast, revealed a strict dependency on homologous growth factor for their continued proliferation in suspension culture. The findings support a progression model of lymphomagenesis based upon the utilization, production and, ultimately, emancipation from growth-promoting soluble factors.
authors.forename: J
authors.initials: J
authors.lastname: Gordon
authors.forename: P
authors.initials: P
authors.lastname: Aman
authors.forename: A
authors.initials: A
authors.lastname: Rosén
authors.forename: I
authors.initials: I
authors.lastname: Ernberg
authors.forename: B
authors.initials: B
authors.lastname: Ehlin-Henriksson
authors.forename: G
authors.initials: G
authors.lastname: Klein
mesh_terms: D001402:B-Lymphocytes / Q000378:metabolism*; D002051:Burkitt Lymphoma / Q000473:pathology; D002460:Cell Line; D006133:Growth Substances / Q000494:pharmacology*; D004854:Herpesvirus 4, Human; D006801:Humans; D015847:Interleukin-4; D007945:Leukemia, Lymphoid / Q000473:pathology; D008222:Lymphokines / Q000494:pharmacology*; D008223:Lymphoma / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology; D008954:Models, Biological; D009101:Multiple Myeloma / Q000473:pathology
chemical_list: D006133:Growth Substances; D008222:Lymphokines; D015847:Interleukin-4