Properties of temperature-sensitive mutants of parainfluenza virus type 3 selected during the course of persistent infection.
We investigated properties of the ts mutants that were selected during the course of persistent infection of Vero cells by parainfluenza virus type 3. The mutants demonstrated leakiness when infecting cells at high MOI and interfered with the growth of wild type virus, apparently by inhibiting a step prior to RNA synthesis.
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D000818:Animals; D002460:Cell Line; D002522:Chlorocebus aethiops; D005814:Genes, Viral; D009154:Mutation; D010224:Parainfluenza Virus 3, Human / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D012367:RNA, Viral / Q000096:biosynthesis; D018108:Respirovirus / Q000235:genetics*; D013696:Temperature; D014762:Viral Interference; D014779:Virus Replication
D012367:RNA, Viral