Benzodiazepine receptors are not involved in the neurotoxicity and anti-electroshock activity of phenytoin in mice.
The present study was undertaken to investigate whether benzodiazepine receptors are involved in either the anticonvulsant activity of phenytoin against supramaximal seizures or maximal threshold seizures induced by electroshock or the neurotoxicity of phenytoin. Ro 15-1788, a benzodiazepine receptor antagonist, reversed the anticonvulsant activity of clonazepam against both supramaximal and maximal threshold seizures induced by electroshock but not that of phenytoin. Moreover, Ro 15-1788 did not decrease the neurotoxicity of phenytoin. These results suggest that benzodiazepine receptors are not involved in either the anticonvulsant action of phenytoin against seizures induced by electroshock or the neurotoxicity of phenytoin.
Chweh
A Y
AY
Swinyard
E A
EA
Wolf
H H
HH
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D002998:Clonazepam / Q000494:pharmacology; D004347:Drug Interactions; D004597:Electroshock; D005442:Flumazenil; D008297:Male; D051379:Mice; D010672:Phenytoin / Q000494:pharmacology* / Q000633:toxicity; D011963:Receptors, GABA-A / Q000187:drug effects*; D012640:Seizures / Q000209:etiology / Q000517:prevention & control*
D001570:Benzodiazepinones; D011963:Receptors, GABA-A; D005442:Flumazenil; D002998:Clonazepam; D010672:Phenytoin