title: [Blood polymorphism in the study of isolated communities].
abstract: Isolated communities offer a unique opportunity for the study of biological and social consequences of consanguinity and migration. The studies of genetic polymorphisms have contributed greatly, not only to knowledge of the genetic constitution of a given individual and population, but also to clarify either relationship between structure and function of polymorphic traits or the susceptibility to multifactorial diseases, in which interaction between the gene and environment cannot be ignored. For over 25 years, we have investigated the effect of consanguinity and genetic polymorphisms in 9 isolated communities in Western Japan. We reported here different values of gene frequency for each polymorphic trait, compared with the neighboring communities and described how we applied these data to clarification of the genetic constitution of isolated communities as well as of genetic susceptibility to some diseases.
authors.affiliation: Département de Médecine interne et de Génétique médicale, Ecole de Médecine de Fukui, Japon.
authors.forename: N
authors.initials: N
authors.lastname: Fujiki
authors.forename: M
authors.initials: M
authors.lastname: Hirayama
authors.forename: M
authors.initials: M
authors.lastname: Nomura
authors.forename: M
authors.initials: M
authors.lastname: Nakanaga
authors.forename: K
authors.initials: K
authors.lastname: Mano
mesh_terms: D000741:Anemia, Aplastic / Q000235:genetics; D001789:Blood Group Antigens; D003241:Consanguinity; D004198:Disease Susceptibility; D005787:Gene Frequency; D006801:Humans; D007564:Japan; D007938:Leukemia / Q000235:genetics; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D001789:Blood Group Antigens
vernacular_title: Polymorphisme sanguin dans l'étude des isolats.