title: Perioperative ischemic injury after coronary bypass graft surgery.
abstract: Two hundred twelve patients who underwent isolated coronary bypass graft surgery were prospectively evaluated for perioperative ischemic injury. All patients underwent preoperative and postoperative testing with technetium 99m pyrophosphate first-pass ventriculography combined with myocardial uptake scans, 12-lead electrocardiography, and serial creatinine phosphokinase MB determination. Fifteen percent of the patients had ischemic injury with at least two test results positive, but only 4 percent had positive results of all three tests. No single test proved adequate. Enzyme levels were highly sensitive and had value as a screening test. The electrocardiogram was specific but only moderately sensitive. The single best test was the radionuclide scan with good sensitivity and no false-positive results. All three tests are required to rigorously diagnose ischemic injury.
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: L G
authors.initials: LG
authors.lastname: Hanelin
authors.forename: R C
authors.initials: RC
authors.lastname: Riggins
authors.forename: R C
authors.initials: RC
authors.lastname: Agnew
authors.forename: L S
authors.initials: LS
authors.lastname: Annest
authors.forename: R P
authors.initials: RP
authors.lastname: Anderson
mesh_terms: D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery*; D003402:Creatine Kinase / Q000097:blood; D011756:Diphosphates; D004562:Electrocardiography; D006801:Humans; D007527:Isoenzymes; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D011183:Postoperative Complications / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D012501:Saphenous Vein / Q000637:transplantation; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate
chemical_list: D011756:Diphosphates; D007527:Isoenzymes; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium; D003402:Creatine Kinase