Isolation of a lymphadenopathy-associated virus from a patient with the acquired immune deficiency syndrome.
A virus similar to the lymphadenopathy-associated virus or human T-lymphotropic virus type III, which has been described in association with the acquired immune deficiency syndrome (AIDS) by several laboratories elsewhere in the world, was isolated from a Cape Town patient with lymphadenopathy and acquired immune deficiency. This virus has the characteristic morphogenesis and ultrastructure and its genome encodes the virus-specific p24 protein. It is T-lymphotropic and produces the characteristic cytopathic effect. It can be serially propagated in a human lymphocyte line of the T4+ phenotype. This isolate is being used in diagnostic immunofluorescence assays for virus-specific antibodies.
Becker
M L
ML
Spracklen
F H
FH
Becker
W B
WB
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology*; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D017977:Deltaretrovirus / Q000254:growth & development / Q000302:isolation & purification* / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology*; D008854:Microscopy, Electron; D011863:Radioimmunoassay; D013601:T-Lymphocytes / Q000382:microbiology
D000956:Antigens, Viral