Detection of antibodies to HTLV-I and -III in sera from Japanese hemophiliacs.
Sera from 50 Japanese hemophiliacs were screened for antibodies to human T-lymphotropic retrovirus types I and III (HTLV-I and -III). As a whole, antibody to HTLV-I, antibody to HTLV-III, and antibodies to HTLV-I and -III were detected in sera from 2, 17, and 6 hemophiliacs, respectively. Among them, two hemophiliacs developed acquired immunodeficiency syndrome who were positive for both antibodies to HTLV-I and -III in sera. All of the others were asymptomatic. Most of the blood products transfused into these hemophiliacs were imported from abroad, whence the source of HTLV-III infection presumably originated. However, since quite a high percentage of these antibody-positive hemophiliacs was positive for antibody to HTLV-I, even though they are native residents in HTLV-I nonendemic areas of Japan, some special factors may have participated in HTLV-I infection. These special factors should be investigated in the future.
Abe
T
T
Kinoshita
T
T
Matsuda
J
J
Ryu
T
T
Ting
R C
RC
Aoki
T
T
Robert-Guroff
M
M
Miyakoshi
H
H
Gallo
R C
RC
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D005164:Factor IX / Q000627:therapeutic use; D005169:Factor VIII / Q000627:therapeutic use; D005260:Female; D015483:HIV Antibodies; D006467:Hemophilia A / Q000097:blood / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed; D007136:Immunoglobulins / Q000032:analysis; D007564:Japan; D007694:Killer Cells, Natural / Q000276:immunology; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D012192:Retroviridae Infections / Q000276:immunology
D000914:Antibodies, Viral; D015483:HIV Antibodies; D007136:Immunoglobulins; D005169:Factor VIII; D005164:Factor IX