Intrathymic differentiation and tolerance induction of lymphokine-secreting Lyt-2+ T helper cells.
The present study has assessed thymic influence on the differentiation and recognition specificity of developing Lyt-2+ lymphokine-secreting T cells, and compared it with those of developing Lyt-2+ CTL. It was demonstrated that development of Lyt-2+ lymphokine-secreting Th cells requires an intrathymic differentiation step, and that peripheral Lyt-2+ lymphokine-secreting Th cells, unlike peripheral Lyt-2+ CTL, are profoundly tolerant to intrathymically expressed alloantigens. These data are interpreted as demonstrating that functionally distinct Lyt-2+ T cell populations are heterogeneous in their requirements for differentiation and/or activation.
Mizuochi
T
T
Immunology Branch, National Cancer Institute, Bethesda, MD 20892.
Singer
A
A
D000818:Animals; D000950:Antigens, Ly; D002454:Cell Differentiation; D006183:H-2 Antigens / Q000276:immunology; D007108:Immune Tolerance; D008222:Lymphokines / Q000096:biosynthesis*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D010641:Phenotype; D013154:Spleen / Q000166:cytology; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000145:classification* / Q000166:cytology / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology / Q000637:transplantation
D000950:Antigens, Ly; D006183:H-2 Antigens; D008222:Lymphokines