Type 2 diabetes in Arab patients in Kuwait.
We describe the characteristics of 75 Arab Type 2 diabetic patients in Kuwait. Their age (+/- SD) at onset was 41 +/- 10 years, and fasting serum C-peptide concentration was 0.32 +/- 0.23 nmol/l (n = 51). Fifty-three percent (37/70) possessed HLA-DR3 or -DR4 epitopes, and 64% (47/73) had a family history of diabetes. Data review suggested that they could be segregated into two groups, those under 40 years old at onset (32 +/- 6 years, n = 37), and the remainder (48 +/- 6 years, n = 38) (p less than 0.001). Those in the former group had a significantly higher frequency of a family history of diabetes than those in the latter group (92% vs 38%, p less than 0.001) suggestive of a greater genetic influence on the development of Type 2 diabetes in those with early onset disease.
Richens
E R
ER
Department of Microbiology, Faculty of Medicine, Mubarak Al-Kabeer Hospital, Kuwait.
Abdella
N
N
Jayyab
A K
AK
al-Saffar
M
M
Behbehani
K
K
D000328:Adult; D000367:Age Factors; D001323:Autoantibodies / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007330:Insulin Antibodies / Q000032:analysis; D007730:Kuwait; D008297:Male; D012737:Sex Factors
D001323:Autoantibodies; D002096:C-Peptide; D007328:Insulin; D007330:Insulin Antibodies