Brain myelin of genetically obese mice.
Brain myelin was studied in genetically obese (ob/ob) mice and compared with that of normal (+/+) mice from the same strain. The brain from obese mice had a significantly lower amount of myelin, and marked changes in the fatty acid composition of myelin were observed. In contrast, the myelin cholesterol: phospholipid: galactolipid and the cerebroside: sulfatide molar ratios and also the phospholipid composition were normal. 2',3'-Cyclic nucleotide 3'-phosphohydrolase (CNP) and UDP-galactose ceramide galactosyltransferase (CGalT) enzymatic activities were normal, and 3'-phosphoadenosine 5'-phosphosulfate (PAPS): cerebroside sulfotransferase (CST) was only slightly decreased. Cholesterol esters were not present in the mutant. These results indicate that brain myelination is affected in obese mutant mice.
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D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry; D002554:Cerebrosides / Q000032:analysis; D005227:Fatty Acids / Q000032:analysis; D005700:Galactosyltransferases / Q000378:metabolism; D051147:Ganglioside Galactosyltransferase; D008055:Lipids / Q000032:analysis*; D051379:Mice; D008810:Mice, Inbred C57BL; D009186:Myelin Sheath / Q000032:analysis*; D009765:Obesity / Q000235:genetics / Q000378:metabolism*; D010727:Phosphoric Diester Hydrolases; D013433:Sulfoglycosphingolipids / Q000032:analysis; D015238:Sulfotransferases; D013466:Sulfurtransferases / Q000378:metabolism
D002554:Cerebrosides; D005227:Fatty Acids; D008055:Lipids; D013433:Sulfoglycosphingolipids; D005700:Galactosyltransferases; D051147:Ganglioside Galactosyltransferase; D013466:Sulfurtransferases; D015238:Sulfotransferases; C020556:galactosylceramide sulfotransferase; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D010727:Phosphoric Diester Hydrolases; D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; C571338:Cnp protein, mouse