Dopamine receptors regulate Met-enkephalin content in pituitary.
Met-enkephalin-like immunoreactive material (ME-LI) in the neurointermediate lobe of rat pituitary was dramatically altered by the long-term administration of drugs altering dopamine receptor activity. Treatment with the dopamine receptor antagonist haloperidol resulted in significant increases of ME-LI and treatment with the dopamine receptor agonist bromocriptine resulted in significant decreases of ME-LI in the neurointermediate pituitary. The treatments had considerably less effect on ME-LI in the anterior lobe of the pituitary. These results suggest that dopamine receptor activation or inhibition influences the content of ME-LI in the rat pituitary gland.
George
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Kertesz
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D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D004744:Enkephalin, Methionine / Q000032:analysis*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D010903:Pituitary Gland, Anterior / Q000032:analysis*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology*; D009435:Synaptic Transmission
D011954:Receptors, Dopamine; D001971:Bromocriptine; D004744:Enkephalin, Methionine; D006220:Haloperidol