title: Brain somatostatin receptor subpopulation visualized by autoradiography.
abstract: [125I-Tyr11]somatostatin-14 as well as iodinated D-Tyr1 and Tyr3 derivatives of the cyclic octapeptide somatostatin analog, SMS 201-995 (H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-ol) have been used as radioligands for somatostatin receptor autoradiography in rat brain. Although the cyclic octapeptide ligands label the majority of the regions labeled with [125I-Tyr11]somatostatin, in the cortex and hippocampus only a subpopulation of somatostatin receptors is labeled. Cyclic octapeptide ligands have improved resolution due to their very low non-specific binding.
authors.forename: R
authors.initials: R
authors.lastname: Maurer
authors.forename: J C
authors.initials: JC
authors.lastname: Reubi
mesh_terms: D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017481:Receptors, Somatostatin
chemical_list: D011956:Receptors, Cell Surface; D017481:Receptors, Somatostatin