title: Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism.
abstract: Children with the Beckwith-Wiedemann syndrome have a greatly increased potential for the specific development of the embryonal tumours hepatoblastoma, rhabdomyosarcoma and Wilms' tumour. Data obtained with molecular probes suggest that the association between these disparate, rare tumour types reflects a common pathogenetic mechanism that entails the somatic development of homozygosity for a mutant allele at a locus on human chromosome 11.
authors.forename: A
authors.initials: A
authors.lastname: Koufos
authors.forename: M F
authors.initials: MF
authors.lastname: Hansen
authors.forename: N G
authors.initials: NG
authors.lastname: Copeland
authors.forename: N A
authors.initials: NA
authors.lastname: Jenkins
authors.forename: B C
authors.initials: BC
authors.lastname: Lampkin
authors.forename: W K
authors.initials: WK
authors.lastname: Cavenee
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D000483:Alleles; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006579:Heterozygote; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D051379:Mice; D009154:Mutation; D009368:Neoplasm Transplantation; D009693:Nucleic Acid Hybridization; D012516:Osteosarcoma / Q000235:genetics; D012208:Rhabdomyosarcoma / Q000235:genetics*; D012512:Sarcoma, Ewing / Q000235:genetics; D013577:Syndrome
chemical_list: D004273:DNA, Neoplasm