Effect of a fibrin(ogen)-derived vasoactive peptide on polymorphonuclear leukocyte emigration.
A vasoactive peptide known to increase vascular permeability and corresponding to residues 30-43 of the human fibrinogen B beta-chain induced polymorphonuclear leukocyte emigration in rabbit skin in vivo. The leukocyte emigration was much stronger after 2 h than after 0.5 h. Addition of prostaglandin E2 (PGE2) did not influence the chemotactic activity, which might possibly be explained by a known PGI2 releasing capacity of this peptide. PGE2 enhanced the leukocyte emigration due to leukotriene B4.
Saldeen
K
K
Christie
N
N
Nelson
W R
WR
Movat
H Z
HZ
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects; D015232:Dinoprostone; D005338:Fibrin Fibrinogen Degradation Products / Q000494:pharmacology*; D005340:Fibrinogen / Q000494:pharmacology*; D007975:Leukotriene B4 / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011817:Rabbits
D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; D011458:Prostaglandins E; C045012:fibrinogen Bbeta (30-43); D007975:Leukotriene B4; D005340:Fibrinogen; D015232:Dinoprostone