title: Reexamination of glucose-6-phosphatase activity in the brain in vivo: no evidence for a futile cycle.
abstract: Glucose-6-phosphatase activity in the rat brain in vivo was estimated by measuring the differential loss of tritium and carbon-14 from the glucose pool labeled by a mixture of [2-3H]glucose and [U-14C]glucose. The results provide no evidence of significant dephosphorylation of glucose-6-phosphate and do not support the hypothesis of a futile cycle involving glucose-6-phosphatase activity in the brain.
authors.forename: T
authors.initials: T
authors.lastname: Nelson
authors.forename: G
authors.initials: G
authors.lastname: Lucignani
authors.forename: S
authors.initials: S
authors.lastname: Atlas
authors.forename: A M
authors.initials: AM
authors.lastname: Crane
authors.forename: G A
authors.initials: GA
authors.lastname: Dienel
authors.forename: L
authors.initials: L
authors.lastname: Sokoloff
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D005958:Glucosephosphates / Q000378:metabolism*; D006019:Glycolysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005958:Glucosephosphates; D005952:Glucose-6-Phosphatase; D005947:Glucose