Immunogenicity of a heat-treated recombinant DNA hepatitis B vaccine.
The effect of heating on the reactogenicity and the immunogenicity of a recombinant DNA hepatitis B vaccine was examined. Treatment of this vaccine for one week at 37 degrees C did not significantly alter these properties when compared to vaccine stored at 4 degrees C. These results have important implications in countries where facilities for the transport and handling of vaccines are often inadequate.
Just
M
M
University Children's Hospital, Basel, Switzerland.
Berger
R
R
D000328:Adult; D000956:Antigens, Viral / Q000276:immunology*; D003080:Cold Temperature; D006510:Hepatitis B Antibodies / Q000096:biosynthesis; D017325:Hepatitis B Vaccines; D006358:Hot Temperature; D006801:Humans; D011309:Preservation, Biological; D014612:Vaccines / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
D000956:Antigens, Viral; D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D014612:Vaccines; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines