title: Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins.
abstract: Regions containing similar elements of primary and predicted secondary structure were identified in simian virus 40 large T, adenovirus E1A, c-myc and v-myc proteins by a computer program with a set of highly specific, complex pattern descriptors. In all cases these regions were localized in domains of the respective proteins known to be required for transforming activity. We suggest that these apparently structurally similar regions may mediate a common biological function.
authors.affiliation: Division of Neoplastic Disease Mechanisms, Dana-Farber Cancer Institute, Boston, Massachusetts.
authors.forename: J
authors.initials: J
authors.lastname: Figge
authors.forename: T
authors.initials: T
authors.lastname: Webster
authors.forename: T F
authors.initials: TF
authors.lastname: Smith
authors.forename: E
authors.initials: E
authors.lastname: Paucha
mesh_terms: D017456:Adenovirus Early Proteins; D000595:Amino Acid Sequence; D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000032:analysis*; D001665:Binding Sites; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D002645:Chickens; D006801:Humans; D051379:Mice; D016274:Oncogene Protein p55(v-myc); D009856:Oncogene Proteins, Viral / Q000032:analysis*; D011487:Protein Conformation; D012191:Retroviridae Proteins / Q000032:analysis*; D012984:Software
chemical_list: D017456:Adenovirus Early Proteins; D000952:Antigens, Polyomavirus Transforming; D016274:Oncogene Protein p55(v-myc); D009856:Oncogene Proteins, Viral; D012191:Retroviridae Proteins