title: Toxicity of trimetrexate on hemopoietic progenitor cells in normal mice.
abstract: Single increasing doses of methotrexate (MTX) and trimetrexate (TMQ) were administered to normal mice. Survival of hemopoietic progenitor cells assayed as CFU-S and GM-CFC was determined 24 hr after drug injection. The survival of each population in TMQ-treated animals was not statistically different from that observed in mice treated with MTX. No difference was observed in time-survival curves of hemopoietic progenitor cells comparing TMQ to MTX. TMQ toxicity at the hematological level thus seems comparable to that of MTX.
authors.affiliation: Patologia Speciale Medica B, University of Genoa, Italy.
authors.forename: G V
authors.initials: GV
authors.lastname: Bogliolo
authors.forename: R A
authors.initials: RA
authors.lastname: Lerza
authors.forename: M P
authors.initials: MP
authors.lastname: Mencoboni
authors.forename: A G
authors.initials: AG
authors.lastname: Saviane
authors.forename: I M
authors.initials: IM
authors.lastname: Pannacciulli
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D003114:Colony-Forming Units Assay; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D008727:Methotrexate / Q000633:toxicity; D051379:Mice; D008811:Mice, Inbred DBA; D011799:Quinazolines / Q000633:toxicity*; D016597:Trimetrexate
chemical_list: D011799:Quinazolines; D016597:Trimetrexate; D008727:Methotrexate