title: Alterations of lens metabolism with experimentally induced cataract in rats.
abstract: Rat lenses with experimentally induced cataract (either by naphthalene or by streptozotocin) were analyzed biochemically. Both noxae had some effects in common. Water-soluble protein and aldose reductase activity decreased, and glucose-6-phosphate dehydrogenase, phosphofructokinase and glutathione reductase activity increased. A specific effect of streptozotocin was the rise in glucose, fructose and sorbitol. A specific effect of naphthalene was increased amounts of water-insoluble protein.
authors.affiliation: Department of Experimental Ophthalmology, University of Bonn, FRG.
authors.forename: I
authors.initials: I
authors.lastname: Korte
authors.forename: O
authors.initials: O
authors.lastname: Hockwin
authors.forename: J
authors.initials: J
authors.lastname: Bours
authors.forename: A
authors.initials: A
authors.lastname: Wegener
mesh_terms: D000818:Animals; D002386:Cataract / Q000139:chemically induced / Q000378:metabolism*; D005136:Eye Proteins / Q000378:metabolism; D005632:Fructose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007908:Lens, Crystalline / Q000201:enzymology / Q000378:metabolism*; D009281:Naphthalenes / Q000494:pharmacology; D051381:Rats; D012995:Solubility; D013012:Sorbitol / Q000378:metabolism; D013311:Streptozocin / Q000494:pharmacology; D014867:Water
chemical_list: D005136:Eye Proteins; D009281:Naphthalenes; D014867:Water; C031721:naphthalene; D005632:Fructose; D013012:Sorbitol; D013311:Streptozocin; D005947:Glucose