title: Non-invasive measurements of cell surface receptors.
abstract: None of the current methods for assessing the effects of subtle changes in drug structure on tissue is entirely satisfactory. The observation that 3H-drug molecules emit photons of light when they bind to membrane proteins (called Condensed Phase Radioluminescence) probably represents a significant advance in measuring non-invasively kinetic effects of drugs on beating monolayers of cardiac myocytes. The potential utility of CPR is great.
authors.forename: I A
authors.initials: IA
authors.lastname: Bailey
authors.forename: V
authors.initials: V
authors.lastname: von Tscharner
authors.forename: D R
authors.initials: DR
authors.lastname: Harris
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D015220:Calcium Channels; D002478:Cells, Cultured; D006339:Heart Rate; D007700:Kinetics; D008565:Membrane Proteins / Q000378:metabolism; D009200:Myocardial Contraction; D009206:Myocardium / Q000166:cytology*; D009543:Nifedipine / Q000031:analogs & derivatives / Q000378:metabolism; D009568:Nitrendipine; D051381:Rats; D011955:Receptors, Drug / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D008565:Membrane Proteins; D011955:Receptors, Drug; D011978:Receptors, Nicotinic; D009568:Nitrendipine; D009543:Nifedipine