title: Lack of effect of synthetic atrial natriuretic factor on rubidium uptake by human erythrocytes.
abstract: The effect of synthetic atrial natriuretic factor on the ouabain-sensitive and the furosemide-sensitive rubidium uptake by human erythrocytes has been studied. This peptide with potent diuretic and natriuretic effects did not affect any rubidium uptake system at concentrations of 10(-7) and 10(-9) M. These results do not support that the natriuretic effect is based on the inhibition of active transport systems in the renal tubules.
authors.forename: N
authors.initials: N
authors.lastname: Hernando
authors.forename: C
authors.initials: C
authors.lastname: Caramelo
authors.forename: A
authors.initials: A
authors.lastname: Tejedor
authors.forename: A
authors.initials: A
authors.lastname: Fernandez-Cruz
authors.forename: J M
authors.initials: JM
authors.lastname: López-Novoa
mesh_terms: D009320:Atrial Natriuretic Factor; D001693:Biological Transport, Active / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D009124:Muscle Proteins / Q000494:pharmacology*; D009318:Natriuresis; D010042:Ouabain / Q000494:pharmacology; D012413:Rubidium / Q000097:blood*; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood
chemical_list: D009124:Muscle Proteins; C472955:NPPA protein, human; D010042:Ouabain; D005665:Furosemide; D009320:Atrial Natriuretic Factor; D000254:Sodium-Potassium-Exchanging ATPase; D012413:Rubidium