[Effect of levamisole on the activity of the blood T-lymphocytes and of factors they produce in patients with laryngeal cancer].
The functional activity of T-lymphocytes was studied in 20 donors and in 59 patients with laryngeal tumours, stages II to IV. A considerable decrease in the activity of T-lymphocytes was observed in patients with laryngeal cancer, stages III and IV. Levamisole increased the functional activity of T-lymphocytes in vitro. It was found that spontaneous rosette-formation, PHA-induced lymphocyte proliferation and gamma-interferon production increased while the activity of suppressor T-lymphocytes induced by concanavalin A decreased.
Volosevich
L I
LI
Lukach
E V
EV
Krivokhatskaia
L D
LD
D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007371:Interferon-gamma / Q000096:biosynthesis; D007822:Laryngeal Neoplasms / Q000276:immunology*; D007958:Leukocyte Count / Q000187:drug effects; D007978:Levamisole / Q000494:pharmacology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology; D014407:Tumor Cells, Cultured
D007978:Levamisole; D007371:Interferon-gamma
Vliianie levamizola na aktivnost' T-limfotsitov krovi i produtsiruemykh imi faktorov u bol'nykh rakom gortani.