title: Long-term potentiation in the dentate gyrus: effects of noradrenaline depletion in the awake rat.
abstract: The chronic rat preparation was utilized to study the effects of noradrenaline (NA) depletion on field potentials recorded from the hilus of the fascia dentata. Both single pulses and high-frequency trains were applied to the perforant path (PP). The effects of NA depletion on baseline responses as well as on long-term potentiation (LTP) were examined. Reduced NA levels resulted in an increase in the population spike amplitude and a depression of the population excitatory postsynaptic potential (EPSP). Depleted animals showed significantly higher levels of LTP of the population EPSP, but reduced levels of population spike LTP (measured 13-15 min after tetanization). There were, however, no differences in LTP levels 1 week after the potentiation tests. These results demonstrate that NA levels do not affect that component of LTP which can persist for several weeks.
authors.forename: G B
authors.initials: GB
authors.lastname: Robinson
authors.forename: R J
authors.initials: RJ
authors.lastname: Racine
mesh_terms: D000768:Anesthesia, General; D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D009435:Synaptic Transmission
chemical_list: D010424:Pentobarbital; D009638:Norepinephrine