Accelerated onset of pancuronium with divided doses.
To determine the consequences of administering neuromuscular relaxants in divided doses, pancuronium was given either in a single dose, 0.07 mg X kg-1, or in an initial dose of 0.007 mg X kg-1 followed three minutes later with 0.063 mg X kg-1. When the drug was administered in divided dosage the onset time was reduced, the block was more intense and its duration of action was prolonged. It is suggested that such changes may be advantageous in the provision of rapid intense paralysis.
Doherty
W G
WG
Breen
P J
PJ
Donati
F
F
Bevan
D R
DR
D000768:Anesthesia, General; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009469:Neuromuscular Junction / Q000187:drug effects*; D010197:Pancuronium / Q000008:administration & dosage* / Q000494:pharmacology; D011229:Preanesthetic Medication; D013514:Surgical Procedures, Operative; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors
D010197:Pancuronium