[Allergic contact dermatitis caused by Asteraceae. Identification of an 8,9-epoxythymol-diester as the contact allergen of Arnica sachalinensis].
A pharmacist developed an allergic contact dermatitis while working with Arnica sachalinensis. Patch testing with sesquiterpene lactones was negative. The contact allergen of A. sachalinensis was identified as 10-acetoxy-8,9-epoxy-thymol-isobutyrate. This compound, or structurally related 8,9-epoxythymol-diesters, are often found in Asteraceae. In addition to sesquiterpene lactones, epoxythymol-diesters should be considered as contact allergens. Cross reactions between the two groups of compounds are not expected and could not be demonstrated in our patients.
Passreiter
C M
CM
Institut für Pharmazeutische Biologie, Universität Düsseldorf.
Florack
M
M
Willuhn
G
G
Goerz
G
G
D000328:Adult; D055598:Chemical Phenomena; D002621:Chemistry; D003876:Dermatitis, Atopic / Q000209:etiology*; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000209:etiology*; D005260:Female; D006801:Humans; D010328:Patch Tests; D010946:Plants, Medicinal / Q000032:analysis*; D013943:Thymol / Q000031:analogs & derivatives* / Q000302:isolation & purification
C057029:10-acetoxy-8,9-epoxythymol isobutyrate; D013943:Thymol
Allergische Kontaktdermatitis auf Asteraceae. Identifizierung eines 8,9-Epoxythymoldiesters als Kontaktallergen von Arnica sachalinensis.