Teicoplanin in the treatment of skin and soft tissue infections.
Twenty-five patients with cellulitis or other soft tissue infections were treated with once daily teicoplanin. One patient was withdrawn from the study because of a protocol violation but 27 of the 29 assessable infections in the other 24 patients were clinically cured or improved. Eighteen of the 20 original Gram-positive bacterial isolates (11 Staphylococcus aureus and nine beta-haemolytic streptococcus strains) were completely eradicated. No severe adverse reactions were seen but a rise in the plasma platelet count was noted in the majority of the patients during teicoplanin administration.
Turpin
P J
PJ
Department of Communicable and Infectious Diseases, East Birmingham Hospital, UK.
Taylor
G P
GP
Logan
M N
MN
Wood
M J
MJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002481:Cellulitis / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006020:Glycopeptides / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D012874:Skin Diseases, Infectious / Q000188:drug therapy* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy; D013290:Streptococcal Infections / Q000188:drug therapy; D017334:Teicoplanin
D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D017334:Teicoplanin