Calcimedin, calelectrin: correlation of relatedness.
A statistical method has been used to compare the amino acid compositions of several calelectrin proteins and the 67k calcimedin protein. The validity of the method for determining protein relatedness and ancestry has been established with many different proteins. Torpedo calelectrin, p68 brain calelectrin, 67,000 dalton brain calelectrin, 67,000 bovine aorta protein, 32k lipocortin (and probably 67R lung protein) share considerable homology with each other and with calpactin I or lipocortin II, the pp60src tyrosine kinase substrate. The 67k calcimedin appears to be unrelated to these several proteins, in agreement with biochemical evidence, although limited homology may still be present. The lung 67E protein, calregulin and calmodulin, are unrelated to any of the other proteins.
Moore
P B
PB
Rockefeller University, New York, New York 10021-6399.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D017302:Annexins; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002147:Calmodulin / Q000235:genetics; D002417:Cattle; D006801:Humans; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009928:Organ Specificity; D013045:Species Specificity; D014101:Torpedo
D000596:Amino Acids; D017302:Annexins; D002135:Calcium-Binding Proteins; D002147:Calmodulin; D009419:Nerve Tissue Proteins