Association of HLA and other genetic markers in South Indian patients with pulmonary tuberculosis.
Histocompatibility antigens (A, B & C loci) and 23 other single gene characters were studied in 204 pulmonary tuberculosis patients belonging to a single endogamous group in South India. None of the previously reported associations with HLA antigens was confirmed, nor any new one found. The blood O and Rh negative associations were also not confirmed, although a new association with the Jk blood group system appears possible. Of particular interest is the association with the phosphoglucomutase (PGM1) system, which parallels that found in a different population located some 1000 km away. Relative risks were calculated to measure the resistance of individuals with the PGM1*2+ allele.
Papiha
S S
SS
Department of Human Genetics, University of Newcastle upon Tyne, UK.
Singh
B N
BN
Lanchbury
J S
JS
Roberts
D F
DF
Parsad
C E
CE
Wentzel
J
J
Murty
K J
KJ
D001789:Blood Group Antigens / Q000235:genetics; D004912:Erythrocytes / Q000201:enzymology; D005787:Gene Frequency; D005819:Genetic Markers; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006801:Humans; D007194:India; D010641:Phenotype; D010733:Phosphoglucomutase / Q000235:genetics; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000235:genetics*
D001789:Blood Group Antigens; D005819:Genetic Markers; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D010733:Phosphoglucomutase