Excitability changes reveal decreased sodium permeability in neuropathy.
Nerve excitability was tested in isolated sciatic nerves of rats with acute uremia. Larger than normal stimulating pulses were required to elicit a maximal compound potential, whereas the relative refractory period was unaffected. The threshold range, relative to the absolute threshold, was a good measure of the decreased excitability and may be a useful clinical method.
Brismar
T
T
Tegnér
R
R
D000818:Animals; D008297:Male; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000378:metabolism* / Q000503:physiopathology; D010539:Permeability; D051381:Rats; D012584:Sciatic Nerve / Q000378:metabolism / Q000503:physiopathology; D012964:Sodium / Q000378:metabolism*; D014511:Uremia / Q000378:metabolism* / Q000503:physiopathology
D012964:Sodium