title: Down's syndrome in Hyderabad, India.
abstract: A cytogenetic analysis of Down's syndrome revealed straight trisomy 21 in 96.5 per cent affected. Remaining 3.5 per cent were found to have chromosomal mosaicism. In addition, a normal karyotype was observed in 2 individuals with Down's phenotype. A survey of Down's syndrome in Hyderabad gave an incidence of 1.17 per 1000 or 1 in 853 live births. There was a significant increase in the mean maternal age of the affected over the controls. Sex ratio was also higher in our sample of Down's syndrome as compared to the general population.
authors.affiliation: Institute of Genetics, Hospital for Genetic Diseases, Osmania University, Hyderabad, India.
authors.forename: G S
authors.initials: GS
authors.lastname: Isaac
authors.forename: P S
authors.initials: PS
authors.lastname: Krishnamurty
authors.forename: Y R
authors.initials: YR
authors.lastname: Reddy
authors.forename: Y R
authors.initials: YR
authors.lastname: Ahuja
mesh_terms: D000328:Adult; D002648:Child; D004314:Down Syndrome / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D007194:India; D007621:Karyotyping; D009030:Mosaicism