Alpha globin gene rearrangements in Polynesians are not associated with malaria.
Using gene mapping, 16.3% of Polynesians were shown to have alpha thalassemia. These results are surprising since malaria is not found in Polynesia. Moreover, triplicated alpha gene rearrangements were identified in a further 7.7%, a frequency not seen in other populations.
Trent
R J
RJ
Mickleson
K N
KN
Wilkinson
T
T
Yakas
J
J
Bluck
R
R
Dixon
M
M
Liley
A W
AW
Kronenberg
H
H
D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes; D005312:Fetal Blood / Q000032:analysis; D005838:Genotype; D005914:Globins / Q000235:genetics*; D006801:Humans; D008288:Malaria / Q000097:blood / Q000235:genetics*; D011114:Polynesia; D013789:Thalassemia / Q000235:genetics
D005914:Globins; D004262:DNA Restriction Enzymes