title: Number of loci responsible for the inheritance of high and low activity of paraoxonase.
abstract: On the basis of a Danish family material of Eiberg & Mohr (1981), especially 416 matings with 1595 children where the one parent has high activity of paraoxonase and the other low activity, and the 185 matings with 684 children where both parents have high activity, it is, by consideration of a two-loci model and other alternatives besides the earlier suggested one-locus model, confirmed that segregation into high and low activity is largely or exclusively due to a one-locus system; in case any secondary locus is involved, its most common allele would probably have a frequency above 0.95.
mesh_terms: D000328:Adult; D000483:Alleles; D043303:Aryldialkylphosphatase; D002648:Child; D005787:Gene Frequency; D005799:Genes, Dominant; D005808:Genes, Recessive; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D010641:Phenotype; D010744:Phosphoric Monoester Hydrolases / Q000097:blood / Q000235:genetics*
chemical_list: D010744:Phosphoric Monoester Hydrolases; D043303:Aryldialkylphosphatase