Influence of dietary zinc deficiency and parenteral zinc on rat liver fructose 1,6-bisphosphatase activity.
Fructose 1,6-bisphosphatase activity in liver of rats fed a zinc deficient diet was decreased to 60% of that in zinc adequate controls. Activity in the zinc deprived rats was not restored to control values by in vitro addition of EDTA. When a physiological dose of zinc was tube fed to the depleted rats, activity increased approximately 150% within 0.5 hr of the dose, and by 1 hr plateaued to a level seen in zinc adequate controls. A significant transient decrease in activity occurred following an intraperitoneal zinc load. This is reversible by in vitro addition of EDTA. These results suggest that rat liver fructose 1,6-bisphosphatase activity is highly sensitive to zinc in vivo as has been demonstrated in vitro.
D000818:Animals; D003600:Cytosol / Q000201:enzymology; D004492:Edetic Acid / Q000494:pharmacology; D006597:Fructose-Bisphosphatase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D051381:Rats; D015032:Zinc / Q000172:deficiency / Q000502:physiology*
D004492:Edetic Acid; D006597:Fructose-Bisphosphatase; D015032:Zinc