title: Direct noninvasive assessment of brain metabolism during increased intracranial pressure: potential therapeutic vistas.
abstract: Intracranial pressure was increased in cats by infusing 'mock' CSF intracranially, thus decreasing cerebral perfusion and oxygenation. The cats then randomly received either 50% O2 or 50% O2-5% CO2 by inhalation. As monitored by in vivo near-infrared spectroscopy (NIR), no improvement was noted after 50% O2 whereas 50% O2-5% CO2 resulted in increased perfusion, an oxidation of cytochrome a,a3, an increase in oxyhemoglobin, and reduced quantities of de-oxyhemoglobin (p less than 0.01) despite a further increase in intracranial pressure. The authors conclude that: NIR is a useful means of noninvasively and directly assessing brain metabolism and has advantages over simple ICP monitoring; and continued investigations of CO2 as a possible therapeutic modality after head injury appear warranted.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002245:Carbon Dioxide / Q000008:administration & dosage; D002415:Cats; D002560:Cerebrovascular Circulation; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D007427:Intracranial Pressure; D008991:Monitoring, Physiologic / Q000379:methods; D010100:Oxygen / Q000008:administration & dosage; D010101:Oxygen Consumption; D010108:Oxyhemoglobins / Q000378:metabolism; D013055:Spectrophotometry, Infrared
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; D002245:Carbon Dioxide; C100003:deoxyhemoglobin; D003576:Electron Transport Complex IV; D010100:Oxygen