Essential fatty acids in the liver and adipose tissue of genetically obese mice: effect of supplemental linoleic and gamma-linolenic acids.
Genetically obese mice (ob/ob) and their lean litter-mates were given diets iso-energetically supplemented with sucrose, hydrogenated coconut oil, safflower oil or evening primrose (Oenothera biennis) oil. Weight gain over 15 weeks was significantly greater in the evening primrose oil-supplemented obese mice than in the other groups. In all the groups of obese mice, liver total phospholipids contained proportionally less linoleic acid and more dihomo-gamma-linolenic acid and arachidonic acid than did the lean controls. As a percentage of total fatty acids, n-3 essential fatty acids (EFA) in liver and adipose tissue lipids were significantly lower in the obese mice than in the lean controls. Supplementation with EFA-rich oils (safflower and evening primrose oil) increased the proportional composition of n-6 EFA and decreased the n-3 EFA more in the liver total phospholipids of the lean than the obese mice.
D000273:Adipose Tissue / Q000032:analysis*; D000818:Animals; D001835:Body Weight; D004822:Epididymis / Q000032:analysis; D005228:Fatty Acids, Essential / Q000032:analysis*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology*; D008042:Linolenic Acids / Q000494:pharmacology*; D008099:Liver / Q000032:analysis*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000378:metabolism*; D009929:Organ Size; D010743:Phospholipids / Q000032:analysis; D014280:Triglycerides / Q000032:analysis; D017965:gamma-Linolenic Acid
D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D008042:Linolenic Acids; D010743:Phospholipids; D014280:Triglycerides; D017965:gamma-Linolenic Acid; D019787:Linoleic Acid