Enhancing effect of dietary supplementation with omega-3 fatty acids on plasma fibrinolysis in normal subjects.
A supplement of MaxEPA oil containing 5 g of omega-3 polyunsaturated fatty acids was given for two weeks to nine normal volunteers. The vascular plasminogen activator (VPA) level increased and there was a fall in the levels of inhibitors of vascular plasminogen activator (IPA) and of plasmin, alpha 2-antiplasmin (alpha 2-AP). No significant changes occur in serum cholesterol, triglycerides, HDL or LDL levels.
D000328:Adult; D004041:Dietary Fats / Q000494:pharmacology*; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000097:blood; D015849:Plasminogen Inactivators; D013997:Time Factors; D000979:alpha-2-Antiplasmin / Q000378:metabolism
D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D006023:Glycoproteins; D008055:Lipids; D015849:Plasminogen Inactivators; D000979:alpha-2-Antiplasmin; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid; D010960:Plasminogen Activators