[Changes in the ratio of cyclic nucleotide phosphodiesterase forms in the thymocytes of irradiated mice].
An increase in the activity of cyclic nucleotide phosphodiesterase was noted during the first hour following irradiation of mice with a dose of 11 Gy and after in vitro irradiation of the thymocyte suspension. Using the methods of gel-filtration and sedimentation and in studying the kinetic characteristics it was shown that the effect of radiation changed the degree of the enzyme aggregation, i. e. the share of the dissociated forms, which possessed a higher catalytic activity, increased.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism / Q000528:radiation effects*; D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000378:metabolism / Q000528:radiation effects*; D000818:Animals; D004789:Enzyme Activation / Q000528:radiation effects; D007700:Kinetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000201:enzymology / Q000528:radiation effects*; D014916:Whole-Body Irradiation
D015105:3',5'-Cyclic-AMP Phosphodiesterases; D015106:3',5'-Cyclic-GMP Phosphodiesterases
Izmeneniia v sootnoshenii form fosfodiésterazy tsiklicheskikh nukleotidov v timotsitakh obluchennykh mysheĭ.