Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.
Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.
D000595:Amino Acid Sequence; D004121:Dimethyl Sulfoxide; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000378:metabolism; D011487:Protein Conformation; D011945:Receptors, Angiotensin / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018045:Receptors, Oxytocin; D014961:X-Ray Diffraction
D011945:Receptors, Angiotensin; D011956:Receptors, Cell Surface; D018045:Receptors, Oxytocin; C004748:deaminooxytocin; D010121:Oxytocin; D004121:Dimethyl Sulfoxide