Coxsackie B virus-specific IgM responses in coronary care unit patients.
An enzyme-linked immunosorbent assay (ELISA) test using polyvalent antigens and antisera was used to detect Coxsackie B virus-specific IgM responses in 329 patients admitted to the Coronary Care Unit, Wellington Hospital, New Zealand over a 12-month period. The sera of 30 of 153 (19.6%) patients with acute myocardial infarction (AMI), 16 of 98 (18.4%) with chest pain, and 7 of 46 (15.2%) patients with arrhythmia were positive for Coxsackie B virus-specific IgM. Four of 12 (25%) patients with heart failure were also positive. Over the same period, 178 sex- and age-matched normal blood donors were also studied. Eleven of 178 (6.2%) matched blood donors were positive for Coxsackie B virus-specific IgM. The rates of occurrence of Coxsackie B virus-specific IgM in patients with AMI and in a group of matched controls showed a significant difference (chi 2 = 5.64, p = 0.02).
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D000918:Antibody Specificity; D001145:Arrhythmias, Cardiac; D001782:Blood Donors; D009202:Cardiomyopathies / Q000209:etiology / Q000276:immunology / Q000382:microbiology*; D003325:Coronary Care Units; D003384:Coxsackievirus Infections / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D003937:Diagnosis, Differential; D029822:Enterovirus B, Human / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis; D010146:Pain; D013909:Thorax
D000914:Antibodies, Viral; D007075:Immunoglobulin M