Benzamide potentiation of behavioral apomorphine-induced effects; mechanism involved.
A new N-pyridinyl benzamide was found to potentiate strongly the effects of apomorphine on the motility of reserpinized mice and on circling behavior. Since dopaminergic agonist activity could not account for this potentiation, involvement of alpha 2-adrenergic agonist activity provided the only consistent explanation.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001549:Benzamides / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology; D004357:Drug Synergism; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D012110:Reserpine / Q000494:pharmacology; D012399:Rotation; D015016:Yohimbine / Q000494:pharmacology
D001549:Benzamides; D006892:Hydroxydopamines; D011942:Receptors, Adrenergic, alpha; D015016:Yohimbine; D012110:Reserpine; D016627:Oxidopamine; C049143:3-chloro-N-(4,6-dimethyl-2-pyridiny)benzamide; D001058:Apomorphine