[Action of substances altering the intracellular cAMP level on the enzymes of the oxidative metabolism of xenobiotics].
The substances decreasing (insulin subcutaneously 30 U/kg single dose) and increasing (isadrin, theophylline orally 30 mg/kg five times with 12-hour intervals) the intracellular level of cAMP exert varying effects of the activities of mono-oxygenases of the rat liver endoplasmic reticulum. Insulin decreases aniline binding with cytochrome P-450 and the rate of its p-hydroxylation (after 6, 12 hours), the content of cytochrome P-450 and the rate of NADP.H oxidation (after 12 hours), the rate of NAD.H oxidation (after 24 hours). The activity of NADP.H-nitrotetrazolium reductase, content of cytochrome B5, the rate of aniline p-hydroxylation are increased by theophylline, and the rate of NADP.H and NAD.H oxidation and the content of cytochrome P-450 are increased by theophylline and isadrin.
D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006900:Hydroxylation; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010105:Oxygenases / Q000378:metabolism*; D051381:Rats; D013806:Theophylline / Q000494:pharmacology*; D013997:Time Factors
D000814:Aniline Compounds; D007328:Insulin; D009243:NAD; D009249:NADP; D003577:Cytochrome P-450 Enzyme System; D013806:Theophylline; D000242:Cyclic AMP; D010105:Oxygenases; C023650:aniline
Deĭstvie veshchestv, izmeniaiushchikh vnutrikletochnyĭ uroven' tsAMF, na fermenty okislitel'nogo metabolizma ksenobiotikov.