Potent depressant action of baclofen on hippocampal epileptiform activity in vitro: possible use in the treatment of epilepsy.
Effects of baclofen on the cortical electrical paroxysm were examined using slices of the guinea pig hippocampus. A very low concentration of baclofen (10(-8) M) readily suppressed spontaneous epileptiform discharges of CA3 pyramidal cells, whereas synaptic transmission between mossy fibers and CA3 pyramidal cells were not affected even by 10(-4) M of this drug. Such a strikingly selective depressant action of baclofen on the epileptiform activity raises a possibility that this drug may be effective in the treatment of epilepsy.
D000818:Animals; D000927:Anticonvulsants; D001418:Baclofen / Q000494:pharmacology / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy*; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D010634:Phenobarbital / Q000627:therapeutic use; D009435:Synaptic Transmission / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use
D000927:Anticonvulsants; D002220:Carbamazepine; D005680:gamma-Aminobutyric Acid; D001418:Baclofen; D003975:Diazepam; D010634:Phenobarbital