[In vitro effect of synthetic water-soluble antioxidants of the class of screened phenols on the beta-adrenergic system in the cardiocyte plasma membranes of rats].
Influence of synthetic water-soluble antioxidants gamma-(4-oxi-3,5-ditret-butylphenol) propionate (phenozan) and the potassium salt of phenozan on the signal processing in beta-receptor-adenylate-cyclase complex of rat cardiocyte membranes has been studied. It was demonstrated that these compounds act at the level of signal transduction from receptor to adenylate cyclase catalytic subunit rather than at the level of ligand-receptor complex formation. At concentrations exceeding-10 microM the antioxidants inhibit both isoproterenol-stimulated synthesis of cyclic 3',5'-AMP and accumulation of the products of lipid peroxidation in membranes. It is proposed that in vitro addition of antioxidants on cardiocyte beta-receptor-adenylate-cyclase complex is a result of alteration of physico-chemical properties of membrane lipids caused by these inhibitors of free radical reactions.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D010666:Phenylpropionates / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D012995:Solubility
D000975:Antioxidants; D008054:Lipid Peroxides; D010636:Phenols; D010666:Phenylpropionates; D011943:Receptors, Adrenergic, beta; C047854:fenozan
Vliianie in vitro sinteticheskikh vodorastvorimykh antioksidantov iz klassa ékranirovannykh fenolov na aktivnost' beta-adrenergicheskoĭ sistemy plazmaticheskikh membran kardiotsitov krys.