Enhancing effect of preadministration of carbon tetrachloride on methylazoxymethanol acetate-induced intestinal carcinogenesis.
This study concerns the modifying effect of carbon tetrachloride (CCl4) on methylazoxymethanol acetate (MAM)-induced intestinal carcinogenesis in ACI rats of both sexes. Forty five animals were given CCl4 (0.5 ml/kg body weight) through a stomach tube, followed by an i.p. injection with MAM (25 mg/kg body weight) 24 hours after CCl4 treatment. The paired administrations were done once a week for 4 weeks and animals were observed until sacrifice 30 weeks later. Pretreatment with CCl4 caused not only early death from chemical toxicity of MAM but also an increase in small-bowel tumors.
D000230:Adenocarcinoma / Q000139:chemically induced; D002288:Adenocarcinoma, Mucinous / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D002251:Carbon Tetrachloride / Q000008:administration & dosage / Q000633:toxicity*; D004357:Drug Synergism; D005260:Female; D007414:Intestinal Neoplasms / Q000139:chemically induced*; D008099:Liver / Q000473:pathology; D008297:Male; D008746:Methylazoxymethanol Acetate / Q000633:toxicity*; D051381:Rats; D011912:Rats, Inbred ACI
D001391:Azo Compounds; D008746:Methylazoxymethanol Acetate; D002251:Carbon Tetrachloride