Serum levels of lactoferrin and myeloperoxidase in chronic idiopathic and secondary neutropenia. A preliminary report.
In 20 patients with chronic neutropenia, serum lactoferrin (S-LF) and serum myeloperoxidase (S-MPO) levels were assessed. By immunofluorescence, granulocyte-bound immunoglobulins were detected in 12 patients, whereas circulating immune complexes were found in the blood of 8 patients by the 125-I-C1q-binding test (C1q-BT). In both groups of patients, there was a relative increase of S-LF and a relative or sometimes absolute increase of S-MPO. In the latter group, results of the C1q-BT correlated positively with S-MPO but negatively with neutrophil counts. No correlations between S-LF or S-MPO and the results of the granulocyte immunofluorescence test were found. Our results suggest that S-LF and S-MPO levels may be helpful in the further study of patients with chronic neutropenia, to gain more insight into the pathogenetic mechanisms operative in this disease.
D000380:Agranulocytosis / Q000097:blood*; D002908:Chronic Disease; D003166:Complement Activating Enzymes / Q000032:analysis; D015922:Complement C1q; D005455:Fluorescent Antibody Technique; D006098:Granulocytes / Q000166:cytology; D006801:Humans; D007781:Lactoferrin / Q000097:blood*; D007782:Lactoglobulins / Q000097:blood*; D007958:Leukocyte Count; D009503:Neutropenia / Q000097:blood*; D009195:Peroxidase / Q000097:blood*
D007782:Lactoglobulins; D015922:Complement C1q; D009195:Peroxidase; D003166:Complement Activating Enzymes; D007781:Lactoferrin