Identification and characterization of human erythrocyte muscarinic receptors.
Cholinergic muscarinic but not nicotinic receptors could be detected on the outer surface of the human red blood cell membrane by direct labelled ligand binding. This 3H-QNB binding could be inhibited by atropine. The erythrocyte cholinergic receptor was similar to brain muscarinic receptor in regard to stimulation of cGMP production.
D002122:Calcium Chloride / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D006152:Cyclic GMP / Q000097:blood; D004533:Egtazic Acid / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D011813:Quinuclidinyl Benzilate / Q000097:blood; D011976:Receptors, Muscarinic / Q000378:metabolism* / Q000502:physiology
D011976:Receptors, Muscarinic; D004533:Egtazic Acid; D011813:Quinuclidinyl Benzilate; D002217:Carbachol; D006152:Cyclic GMP; D002122:Calcium Chloride