[Effect 4-aminopyridine on the recovery of segmental reflexes after sectioning of the sciatic nerve in the rat].
L5 ventral root reflex discharges evoked by dorsal root stimulation were studied 3-4 weeks after transection of sciatic nerve in rats; only polysynaptic transmission was found on the side of operation. Injection of 4-aminopyridine (500-600 mg/kg, intraperitoneally) resulted in facilitation of reflex discharges on the intact side and in reappearance of intensive monosynaptic component in such discharges on the affected side. It is concluded that 4-aminopyridine recovers monosynaptic transmission between primary afferents and chromatolysed motoneurons because of increased transmitter liberation.
D015761:4-Aminopyridine; D000631:Aminopyridines / Q000627:therapeutic use*; D000818:Animals; D059348:Peripheral Nerve Injuries; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000502:physiology; D012021:Reflex, Abnormal / Q000188:drug therapy*; D012023:Reflex, Monosynaptic; D013116:Spinal Cord / Q000503:physiopathology*; D013126:Spinal Nerve Roots / Q000502:physiology; D009435:Synaptic Transmission
D000631:Aminopyridines; D015761:4-Aminopyridine
Vliianie 4-aminopiridina na vosstanovlenie segmentarnykh refleksov posle pererezki sedalishchnogo nerva u krys.