N-ras and human cancer.
Activated N-ras genes have been detected in a variety of human tumours and tumour derived cell lines. It has been proposed that mutation or amplification of an N-ras gene represents one of the key steps in the development of some human tumours. Here we discuss the various methods by which activated N-ras genes have been detected, the ways in which they have become activated, and their contributions to the transformed phenotype.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D004273:DNA, Neoplasm / Q000235:genetics*; D019204:GTP-Binding Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000235:genetics*; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis; D010455:Peptides / Q000235:genetics; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D014018:Tissue Distribution; D015291:Transforming Growth Factors
D004273:DNA, Neoplasm; D009838:Oligodeoxyribonucleotides; D010455:Peptides; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D015291:Transforming Growth Factors; D004262:DNA Restriction Enzymes; D019204:GTP-Binding Proteins