Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.
Extensive molecular studies have characterized 15 dimorphic and 2 multiallelic genetic markers within the human alpha-globin gene cluster. Analysis of these markers in 9 populations has shown that the alpha-globin locus is remarkably polymorphic and is therefore an ideal marker on chromosome 16 for the construction of a human genetic linkage map. The combined analysis of 9 polymorphic markers has established alpha-globin haplotypes that provide the means to study the molecular genetics and common mutants of this cluster. The novel association of a conventional restriction fragment length polymorphism haplotype and linked, hypervariable regions of DNA should allow a comparison of the rate of change of such markers.
D000483:Alleles; D004262:DNA Restriction Enzymes; D005796:Genes; D008040:Genetic Linkage; D005819:Genetic Markers; D005914:Globins / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic
D005819:Genetic Markers; D005914:Globins; D004262:DNA Restriction Enzymes