[Baclofen inhibition of synaptic transmission in glomeruli of the olfactory bulb of the frog].
The application of (+/-) baclofen (10(-5) M) to the frog olfactory bulb greatly reduced postsynaptic components of the orthodromic potential, but the antidromic potential was not affected. The effect was not antagonized by bicuculline (10(-4)-10(-3) M). The results suggest that bicuculline-insensitive GABAB-receptors are located on the primary olfactory afferents and may realize presynaptic inhibition in the olfactory bulb.
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001640:Bicuculline / Q000494:pharmacology; D003864:Depression, Chemical; D008564:Membrane Potentials / Q000187:drug effects; D009830:Olfactory Bulb / Q000187:drug effects*; D011896:Rana temporaria; D011963:Receptors, GABA-A; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D011963:Receptors, GABA-A; D001418:Baclofen; D001640:Bicuculline
Ugnetenie baklofenom sinapticheskoĭ peredachi v klubochkakh oboniatel'noĭ lukovitsy liagushki.