Effects of valproate on biogenesis and function of liver mitochondria.
The mitochondrial protein content of liver increased, and mitochondria enlarged after prolonged administration of valproic acid (VPA: N-dipropylacetic acid) to rats. The mitochondria showed low specific activities of membrane-bound enzymes, decreased content of cytochrome aa3, and decreased respiration in states 3 and 4. In vitro studies of amino acid incorporation suggested a decrease in protein synthesis in liver mitochondria from VPA-treated rats. Prolonged administration of VPA seems to impair mitochondrial structure and function.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002648:Child; D003576:Electron Transport Complex IV / Q000378:metabolism; D006801:Humans; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D001678:Organelle Biogenesis; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects; D014635:Valproic Acid / Q000494:pharmacology*
D000596:Amino Acids; D011506:Proteins; D014635:Valproic Acid; D003576:Electron Transport Complex IV