[Early manifestations and mechanism of the neurotoxic action of organophosphorus pesticides].
The inhibition of neurotoxic esterase activity in chicken brain has been studied in vitro and in vivo. Aphos exposure, causing chicken paralysis, has demonstrated that the initial stage of delayed neurotoxicity was significant esterase activity inhibition (by 60-80%) within 3-24 hours after the pesticide administration. The inhibition of cholinesterase activity occurred both in the blood and sciatic nerve. The delayed conduction through peripheral nerves caused by demyelination has been revealed in the latent period (before the clinical signs of intoxication).
D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000037:antagonists & inhibitors; D002645:Chickens; D002800:Cholinesterase Inhibitors; D007306:Insecticides / Q000633:toxicity*; D007928:Lethal Dose 50; D009431:Neural Conduction / Q000187:drug effects; D009943:Organophosphorus Compounds; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D009943:Organophosphorus Compounds; D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase
O rannikh proiavleniiakh i mekhanizme neĭrotoksicheskogo deĭstviia fosforoorganicheskikh pestitsidov.