[Lymphoid cells in the venous blood of 100 female patients with breast carcinoma. Follow-up studies].
The following blood cells were examined in 100 patients with invasive carcinoma of the breast and 100 control patients without malignant disease: leukocytes, lymphocytes, monocytes and different sub-populations of lymphoid cells. Lymphoid cells were characterized by E-, EA- and EAC-rosetting technique, alphanaphtyl acetate esterase activity and by the ability of latex phagocytosis. Both groups showed no significant differences. In 81 patients undergoing postoperative radiation therapy lymphocytes and lymphoid cells were reduced considerably. These changes were still evident after 12 months (6 months after completion of radiotherapy). Mainly the T lymphocytes were effected by this decrease. A negative effect of the radiation induced reduction of immune competent cells must be discussed and examined further by clinical trials.
D002293:Adenocarcinoma, Scirrhous / Q000276:immunology / Q000532:radiotherapy / Q000601:surgery; D001402:B-Lymphocytes / Q000276:immunology / Q000528:radiation effects; D001943:Breast Neoplasms / Q000276:immunology* / Q000532:radiotherapy / Q000601:surgery; D002277:Carcinoma / Q000276:immunology* / Q000532:radiotherapy / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000276:immunology / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology*; D011182:Postoperative Care; D011379:Prognosis; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology / Q000528:radiation effects; D014680:Veins
Lymphoide Zellen im Venenblut von 100 Patientinnen mit Mammakarzinom. Eine Verlaufsbeobachtung.