The N-terminal amino acid sequence from alpha 1-antitrypsin isolated from liver inclusion bodies.
The alpha 1-antitrypsin from the liver of a subject with alpha i-antitrypsin deficiency was purified and subjected to automated Edman degradation. The N-terminal amino acid sequence from position 1 to 12 was identical to that in plasma alpha 1-antitrypsin, type Z. This result precludes that the intrahepatic accumulation of Z alpha 1-antitrypsin is due to a defective removal of a signal peptide.
D000595:Amino Acid Sequence; D001322:Autoanalysis; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007122:Immunoelectrophoresis; D002479:Inclusion Bodies / Q000032:analysis*; D008099:Liver / Q000166:cytology*; D000515:alpha 1-Antitrypsin / Q000032:analysis*
D000515:alpha 1-Antitrypsin