Baclofen overdose with cardiac conduction abnormalities: case report and review of the literature.
Cardiac conduction abnormalities and hypertension developed in a patient who ingested approximately 500 mg of baclofen (Lioresal). The patient also exhibited the more common features of baclofen overdose including coma, respiratory depression, hypotonia, and hyporeflexia. A review of the literature and a discussion of the interesting manifestations and treatment of baclofen overdose are included.
D000328:Adult; D001418:Baclofen / Q000506:poisoning*; D001919:Bradycardia / Q000139:chemically induced; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D009207:Myoclonus / Q000139:chemically induced; D011963:Receptors, GABA-A / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced
D011963:Receptors, GABA-A; D001418:Baclofen