Sodium butyrate selectively inhibits host cell glycoprotein synthesis in human fibroblasts infected with cytomegalovirus.
Host cell as well as viral DNA synthesis in human fibroblasts infected with human cytomegalovirus was found to be largely resistant even to high concentrations of sodium butyrate. Likewise, production of viral progeny was reduced by 1-2 orders of magnitude but not abolished. On the other hand, the drug allowed (modified) glycosylation only of viral polypeptides whereas that of host proteins was suppressed. Immunofluorescence studies on living cells suggested that butyrate may interfere with processing and intracellular transport of virus-specific surface membrane antigens.
D000954:Antigens, Surface / Q000096:biosynthesis; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D002472:Cell Transformation, Viral; D003587:Cytomegalovirus; D004261:DNA Replication / Q000187:drug effects; D004279:DNA, Viral / Q000096:biosynthesis; D004591:Electrophoresis, Polyacrylamide Gel; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D005470:Fluorometry; D006023:Glycoproteins / Q000096:biosynthesis*; D006801:Humans
D000954:Antigens, Surface; D002087:Butyrates; D004279:DNA, Viral; D006023:Glycoproteins; D020148:Butyric Acid