Subepidermal vesicular dermatosis and sensory peripheral neuropathy caused by pyridoxine abuse.
A woman who had ingested 2 gm of pyridoxine (vitamin B6) daily for 2 years for menstrual water retention developed a subepidermal vesicular eruption on the dorsa of the hands and toes, as well as a sensory peripheral neuropathy. The cutaneous and neurologic manifestations subsided about 2 months after discontinuation of the pyridoxine. The possible relationship of subepidermal vesicular eruptions caused by pyridoxine abuse to epidermolysis bullosa acquisita is discussed.
D005260:Female; D006801:Humans; D008598:Menstruation; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D011736:Pyridoxine / Q000008:administration & dosage / Q000009:adverse effects*; D012651:Self Medication / Q000009:adverse effects; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*; D013997:Time Factors
D011736:Pyridoxine