title: A simple nonequilibrium thermodynamic description of some inhibitors of oxidative phosphorylation.
abstract: We propose a macroscopic description of some inhibitors of oxidative phosphorylation based on a simple modification of the phenomenological coefficients appearing in the constitutive equations of linear irreversible thermodynamics. In this theoretical model, we consider protonophores, some ATPase inactivators and some electron-chain inhibitors, and we provide quantitative expressions for their consequences on the protonmotive force, oxidation flux and phosphorylation flux as well as on heat generation.
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000818:Animals; D006224:Cricetinae; D006168:Guinea Pigs; D008099:Liver / Q000378:metabolism; D008433:Mathematics; D008928:Mitochondria / Q000378:metabolism; D009840:Oligomycins / Q000494:pharmacology; D010085:Oxidative Phosphorylation / Q000187:drug effects; D011522:Protons; D051381:Rats; D013816:Thermodynamics; D014475:Uncoupling Agents / Q000494:pharmacology
chemical_list: D009840:Oligomycins; D011522:Protons; D014475:Uncoupling Agents; D000251:Adenosine Triphosphatases