Enzymatic deficiencies of the immune system cells in patients with cancer of the larynx and other malignancies.
Activity of N-acetyl-beta-D-glucosaminidase, beta-glucuronidase, and acid phosphatase and myeloperoxidase was determined in neutrophils and lymphocytes of patients with cancer of the larynx and precancerous states of the larynx as well as--for comparative reasons--in patients with malignant tumors of female generation organs, breast carcinoma, cancer of the stomach and endometriosis. The main result of investigations performed was in fact that intracellular deficiency of beta-glucuronidase within the neutrophils characterizes patients with cancer and precancerous states of the larynx. Patients with cancer of the larynx show additionally a deficiency of neutrophil myeloperoxidase. Deficiency of N-acetyl-beta-D-glucosaminidase occurs, in contrast, in patients with malignancies of female generation organ. Activity of myeloperoxidase in neutrophils from patients with gastric carcinoma is slightly elevated.
D000118:Acetylglucosaminidase / Q000172:deficiency; D002294:Carcinoma, Squamous Cell / Q000201:enzymology; D004715:Endometriosis / Q000201:enzymology; D004798:Enzymes / Q000172:deficiency*; D005260:Female; D005966:Glucuronidase / Q000172:deficiency; D006801:Humans; D007822:Laryngeal Neoplasms / Q000201:enzymology*; D007971:Leukoplakia / Q000201:enzymology; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D009504:Neutrophils / Q000201:enzymology*; D010212:Papilloma / Q000201:enzymology; D009195:Peroxidase / Q000172:deficiency; D011230:Precancerous Conditions / Q000201:enzymology; D013274:Stomach Neoplasms / Q000201:enzymology; D002583:Uterine Cervical Neoplasms / Q000201:enzymology; D014594:Uterine Neoplasms / Q000201:enzymology
D004798:Enzymes; D009195:Peroxidase; D005966:Glucuronidase; D000118:Acetylglucosaminidase