The role of cAMP and prostaglandins in gastric acid secretion after pentagastrin administration.
The role of cAMP and prostaglandins as specific intracellular effectors of gastrin action at the level of the parietal cells has not been sufficiently clarified. For this reason we studied the responses of the parietal cells to stimulation with pentagastrin (6 micrograms/kg i.m.) during theophylline infusion (which causes an increase in the intracellular cAMP) and during acetylsalicylic acid infusion (which inhibits the prostaglandin synthesis) in 28 healthy volunteers. Both theophylline and acetylsalicylic acid provoked a significant increase of gastric acid secretion after pentagastrin. Our results suggest that: 1. an increase in intracellular cAMP may be the basis of the stimulatory effect of gastrin on gastric acid secretion 2. a decrease in the synthesis of prostaglandins may lead to a greater gastric acid response after pentagastrin.
D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000031:analogs & derivatives / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D005744:Gastric Acid / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin / Q000494:pharmacology*; D011453:Prostaglandins / Q000378:metabolism*; D013806:Theophylline / Q000494:pharmacology
D011453:Prostaglandins; D013806:Theophylline; D000242:Cyclic AMP; D010418:Pentagastrin; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate