Chronic treatment with phenobarbital decreases the expression of rat liver EGF and insulin receptors.
In male F-344 rats fed phenobarbital 0.05% with chow the binding of EGF to microsomal and Golgi liver fractions decreased after 2 weeks, dropped by more than 60% after one month and remained low for the following five months of the experiment. The binding of insulin remained stable for 2 weeks after which it decreased by half. In both cases the receptors decreased in number without changes in their affinity. Autophosphorylation of the receptors showed changes parallel to those of the binding of the ligands.
D000818:Animals; D001667:Binding, Competitive; D066246:ErbB Receptors; D006056:Golgi Apparatus / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology*; D010766:Phosphorylation; D051381:Rats; D011916:Rats, Inbred F344; D011972:Receptor, Insulin / Q000187:drug effects* / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism
D011956:Receptors, Cell Surface; D066246:ErbB Receptors; D011972:Receptor, Insulin; D010634:Phenobarbital