Electrophysiologic effects of prazosin during acute myocardial ischemia.
Prazosin, 100 micrograms/kg, had no effect on baseline refractoriness or intraventricular conduction in anesthetized dogs. During 1 h of coronary artery occlusion followed by reperfusion, prazosin significantly blunted the shortening of the ventricular effective refractory periods within ischemic myocardial region relative to vehicle-treated animals. Prazosin treatment also prevented the delayed conduction of paced ventricular complexes entering and exiting the ischemic zone. These effects may be associated with the blockade of alpha 1-adrenoceptor activation during the acute phase of myocardial ischemia.
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004594:Electrophysiology; D008297:Male; D011224:Prazosin / Q000494:pharmacology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology; D014693:Ventricular Fibrillation / Q000517:prevention & control
D011942:Receptors, Adrenergic, alpha; D011224:Prazosin