The yeast alpha-factor receptor: structural properties deduced from the sequence of the STE2 gene.
The STE2 gene of the yeast Saccharomyces cerevisiae encodes a component of the receptor for the oligopeptide pheromone alpha-factor. We have cloned and determined the nucleotide sequence of the STE2 gene. A sequence involved in the control of cell-type expression of the STE2 gene was found 5' of an open reading frame that could encode a protein of 431 amino acids. The predicted STE2 protein contains seven hydrophobic segments, suggesting that the alpha-factor receptor is an integral membrane protein. No extensive homology at the primary sequence level was detected between the predicted STE2 protein and other available protein sequences.
D000595:Amino Acid Sequence; D001483:Base Sequence; D004271:DNA, Fungal / Q000235:genetics; D005656:Fungal Proteins / Q000235:genetics; D005800:Genes, Fungal; D005816:Genetic Complementation Test; D000072235:Mating Factor; D008565:Membrane Proteins / Q000235:genetics; D010455:Peptides / Q000378:metabolism; D010675:Pheromones / Q000378:metabolism; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D012995:Solubility
D004271:DNA, Fungal; D005656:Fungal Proteins; D008565:Membrane Proteins; D010455:Peptides; D010675:Pheromones; D011956:Receptors, Cell Surface; D000072235:Mating Factor