Pharmacokinetics of lithium in the dog.
The pharmacokinetics of lithium were determined in eight adult dogs. The data were fitted to a two-compartment model. Single intravenous doses of lithium chloride, and single oral doses of lithium carbonate were used. The mean plasma lithium half-life (t1/2) following the single intravenous dose was 21.6 h, and the mean apparent specific volume of distribution of the central compartment (V'c) was 0.189 l/kg. Mean bioavailability was 78.8% following oral administration.
D000284:Administration, Oral; D000818:Animals; D002712:Chlorides / Q000378:metabolism*; D004285:Dogs; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008094:Lithium / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D016651:Lithium Carbonate; D018021:Lithium Chloride; D008297:Male; D008954:Models, Biological; D012016:Reference Values; D012559:Schizophrenia / Q000097:blood; D013552:Swine
D002712:Chlorides; D016651:Lithium Carbonate; D008094:Lithium; D018021:Lithium Chloride