Antibody to mouse alpha/beta interferon abrogates Pichinde virus-induced liver lesions in suckling mice.
Infection of newborn C3HeB/FeJ mice with the arenavirus Pichinde resulted in stunted growth, severe liver cell degeneration, and death. Administration of sheep anti-mouse alpha/beta interferon globulin completely abrogated liver lesions in virus-infected mice, although it did not decrease the incidence of mortality. These results indicate that endogenous interferon may be responsible for some manifestations of viral disease.
D000818:Animals; D000833:Animals, Suckling; D000906:Antibodies; D006477:Arenaviruses, New World / Q000502:physiology; D006478:Hemorrhagic Fever, American / Q000150:complications* / Q000382:microbiology; D007370:Interferon Type I / Q000276:immunology / Q000502:physiology*; D008099:Liver / Q000473:pathology*; D051379:Mice; D008809:Mice, Inbred C3H; D009336:Necrosis
D000906:Antibodies; D007370:Interferon Type I