Molecular mechanisms of platelet aggregation.
Recent studies suggest that platelet stimulation leads to the induction of specific fibrinogen receptors, which have been identified as the platelet membrane glycoprotein IIb-IIIa complex. The binding of fibrinogen initiates the reversible primary phase of aggregation. With a strong stimulus, thrombospondin is released from the platelet alpha-granules. By interacting with fibrinogen, thrombospondin serves to stabilize the platelet aggregates, which leads to a secondary irreversible phase of aggregation.
D001665:Binding Sites; D001791:Blood Platelet Disorders / Q000097:blood / Q000209:etiology; D001792:Blood Platelets / Q000378:metabolism / Q000502:physiology; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D010980:Platelet Membrane Glycoproteins; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000378:metabolism; D013915:Thrombasthenia / Q000097:blood / Q000209:etiology
D006023:Glycoproteins; D008565:Membrane Proteins; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface