title: Observations on transplacental infection with bluetongue virus in sheep.
abstract: Twenty-four ewes were inoculated with 1 of 2 strains of bluetongue virus type 4 at 40, 60, or 80 days of gestation. Two ewes aborted, 2 ewes died, and 1 was killed during the experiment, but their fetuses were recovered. At term, 2 mummified fetuses, 4 dead lambs, and 17 clinically healthy lambs were produced by 12 sheep, and the remaining 7 sheep were barren. Porencephaly and cerebellar dysgenesis were found in term lambs born to sheep inoculated at 40 and 60 days of gestation. Radiographic examination of 12 fetuses showed developmental ages far less than their chronologic age; 8 fetuses had skeletal growth-retardation lines, which were also observed in the dead lambs. A systemic lymphoreticular hyperplasia was observed in the dead lambs and in all lambs at 12 weeks of age; in 4 of the latter, granulomatous reactions were present in the liver and kidney. Lungs of the full-term lambs were reduced in weight and showed poor alveolar development and mononuclear cell infiltration, which persisted in the 12-week-old lambs. It was concluded that bluetongue virus is capable of causing not only gross abnormalities of the CNS, but also generalized growth retardation and fetal lymphoreticular hyperplasia.
mesh_terms: D000034:Abortion, Veterinary / Q000453:epidemiology; D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D001819:Bluetongue / Q000276:immunology / Q000473:pathology / Q000635:transmission*; D001820:Bluetongue virus / Q000276:immunology / Q000302:isolation & purification*; D001921:Brain / Q000473:pathology; D005260:Female; D005313:Fetal Death / Q000453:epidemiology / Q000662:veterinary; D005317:Fetal Growth Retardation / Q000453:epidemiology / Q000662:veterinary; D007668:Kidney / Q000473:pathology; D008168:Lung / Q000473:pathology; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000635:transmission / Q000662:veterinary*; D012087:Reoviridae / Q000302:isolation & purification*; D012756:Sheep; D012757:Sheep Diseases / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral