[Determination of cyclic AMP and protein kinases in the diagnosis of colonic tumors].
The cAMP level and the activity of cAMP-dependent and independent protein kinases were measured in adenomatous polyps, villous polyps (premalignant condition) and adenocarcinomas. The cAMP concentration and ratio of cAMP level versus cAMP-independent casein kinase activity were significantly lower in adenocarcinomas compared to adenomatous polyps, thus permitting differentiation between benign and malignant lesions. The cAMP versus cAMP-dependent histone kinase level ratio was used as a test for differentiation between malignancies and premalignant condition. It was markedly lower in adenocarcinomas than in villous polyps.
D000230:Adenocarcinoma / Q000032:analysis / Q000175:diagnosis*; D047388:Casein Kinases; D003110:Colonic Neoplasms / Q000032:analysis / Q000175:diagnosis*; D000242:Cyclic AMP / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007417:Intestinal Polyps / Q000032:analysis / Q000175:diagnosis*; D008297:Male; D006656:Protamine Kinase / Q000032:analysis; D011494:Protein Kinases / Q000032:analysis*
D000242:Cyclic AMP; D011494:Protein Kinases; D047388:Casein Kinases; D006656:Protamine Kinase
Opredelenie tsAMF i proteinkinaz v diagnostike opukholeĭ tolstoĭ kishki.