A filamentous distribution for the herpes simplex virus type 2-encoded major DNA-binding protein.
Monoclonal antibodies reacting with the herpes simplex virus (HSV)-encoded major DNA-binding protein defined an intracellular filamentous network. This network was associated predominantly with the infected cell nucleus and occurred in cells infected with HSV type 2. It did not co-distribute with microfilaments, microtubules or intermediate filaments, and DNA synthesis was required for its formation. We suggest explanations for the occurrence and function of this novel filamentous network structure.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D002460:Cell Line; D002467:Cell Nucleus / Q000648:ultrastructure; D006224:Cricetinae; D003599:Cytoskeleton / Q000648:ultrastructure; D004261:DNA Replication; D004279:DNA, Viral / Q000096:biosynthesis; D004268:DNA-Binding Proteins / Q000032:analysis* / Q000276:immunology; D005347:Fibroblasts / Q000382:microbiology / Q000648:ultrastructure*; D005455:Fluorescent Antibody Technique; D007668:Kidney; D008647:Mesocricetus; D018139:Simplexvirus / Q000032:analysis* / Q000276:immunology; D014764:Viral Proteins / Q000032:analysis* / Q000276:immunology; D014779:Virus Replication
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D004279:DNA, Viral; D004268:DNA-Binding Proteins; D014764:Viral Proteins; C046299:herpes simplex virus type 2 protein ICSP 11-12