title: Structural and functional studies on the interstitial collagen genes.
abstract: An understanding of the molecular mechanisms which control expression of the type I and III collagen genes may provide a rational basis for the design of more effective therapeutic approaches to fibrotic diseases. The structure of the interstitial collagen genes is reviewed and potential sites which could control their expression are examined. One approach to the study of the regulation of these genes consists in DNA-mediated gene transfection experiments and is discussed in this paper.
mesh_terms: D000818:Animals; D001483:Base Sequence; D003094:Collagen / Q000235:genetics*; D003850:Deoxyribonuclease I; D004720:Endonucleases; D005347:Fibroblasts / Q000378:metabolism; D005796:Genes; D006801:Humans; D008745:Methylation; D051379:Mice; D010442:Peptide Chain Initiation, Translational; D011401:Promoter Regions, Genetic; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D015719:Single-Strand Specific DNA and RNA Endonucleases; D013045:Species Specificity; D014162:Transfection
chemical_list: D012333:RNA, Messenger; D003094:Collagen; D004720:Endonucleases; D003850:Deoxyribonuclease I; D015719:Single-Strand Specific DNA and RNA Endonucleases