title: Plane warts under spontaneous regression. Immunopathologic study on cellular constituents leading to the inflammatory reaction.
abstract: Immunohistologically, cellular infiltrates in regressing plane warts were mainly composed of lymphocytes and mononuclear phagocytes. There were many infiltrating T lymphocytes. Immunoelectron microscopic observation demonstrated that both helper/inducer and suppressor/cytotoxic phenotypes of T lymphocytes infiltrated in the lesions. OKT6-positive cells were observed in the dermis as well as in the epidermis. Moreover, as noted in allergic contact dermatitis, the apposition of T lymphocytes to Langerhans' cell-like cells could be seen. Lymphocytes and a small number of mononuclear phagocytes were found adjacent to damaged keratinocytes in the epidermis, the picture of which has been described as satellite cell necrosis, a hallmark of cytotoxic reaction by aggressors. These findings suggest that specific cell-mediated immunity against virus-infected keratinocytes takes place in the process of regressing plane warts.
mesh_terms: D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007124:Immunoenzyme Techniques; D007249:Inflammation / Q000276:immunology; D007801:Langerhans Cells / Q000276:immunology; D008297:Male; D008854:Microscopy, Electron; D027383:Papillomaviridae / Q000276:immunology; D010586:Phagocytes / Q000276:immunology; D012075:Remission, Spontaneous; D012867:Skin / Q000276:immunology; D012871:Skin Diseases / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology; D014860:Warts / Q000276:immunology* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal