title: Phosphorylase phosphatase and phosphatase activating-kinase FA in growing rat muscles.
abstract: The activities of phosphorylase phosphatase and of FA, the kinase that activates phosphatase, were measured in rat skeletal muscle from birth to 200 g body weight. Throughout this period part of phosphatase was always spontaneously active. The activity could be further increased by trypsin, but did not additionally increase when Mn2+ was present. During the first 15-20 days of life most of the phosphatase was cytosolic. Then it decreased in this fraction and more phosphatase was found in glycogen particles, to reach the adult level at about 50 g body weight. Also the activity of the kinase FA was lower for the first 10 days, then it increased attaining the adult level again at about 50 g. These results are compared to those on phosphorylase activity and glycogen level in muscle and on serum insulin during growth.
mesh_terms: D000375:Aging; D000818:Animals; D003600:Cytosol / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006003:Glycogen / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008297:Male; D008345:Manganese / Q000494:pharmacology; D024510:Muscle Development; D009132:Muscles / Q000201:enzymology; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D010765:Phosphorylase Phosphatase / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D054645:Protein Phosphatase 1; D051381:Rats; D011919:Rats, Inbred Strains; D014357:Trypsin / Q000494:pharmacology
chemical_list: D007328:Insulin; D008345:Manganese; D006003:Glycogen; D011494:Protein Kinases; C045455:phosphatase-1 kinase; D010749:Phosphoprotein Phosphatases; D054645:Protein Phosphatase 1; D010765:Phosphorylase Phosphatase; D014357:Trypsin