title: Sulbactam kinetics and excretion into breast milk in postpartum women.
abstract: We gave intravenous infusions of sulbactam, a beta-lactamase inhibitor, in combination with ampicillin or cephalothin to women 2 days after cesarean section delivery. The elimination t1/2 was 1.0 hours, the volume of distribution at steady state was 268 ml/kg, and renal clearance was 295 ml/min. These values are similar to those in normal young men and in surgical patients and suggest that dose regimens of sulbactam will not need adjustment in the postpartum period. Sulbactam concentrations in breast milk averaged 0.5 micrograms/ml, a value similar to that of several beta-lactam antibiotics.
mesh_terms: D000667:Ampicillin / Q000378:metabolism / Q000627:therapeutic use; D002512:Cephalothin / Q000378:metabolism / Q000627:therapeutic use; D002849:Chromatography, Gas; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008297:Male; D008895:Milk, Human / Q000032:analysis*; D010397:Penicillanic Acid / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D011184:Postoperative Period; D011247:Pregnancy; D011645:Puerperal Infection / Q000517:prevention & control; D013407:Sulbactam
chemical_list: D004338:Drug Combinations; D000667:Ampicillin; D010397:Penicillanic Acid; D002512:Cephalothin; D013407:Sulbactam