[Bone marrow suppressor cells of patients with viral and alcoholic liver cirrhoses].
A study was made of bone marrow suppressor cells potencies in 12 viral and alcoholic liver cirrhosis patients and 6 healthy persons using a method of the registration of bone marrow suppressor cells activity in the inhibition of xenogenic target cells proliferation. The activity of bone marrow suppressor cell in viral and alcoholic liver cirrhosis was significantly lowered as compared to that of the healthy donors. Besides, the spontaneous bone marrow cells proliferation level both in viral and alcoholic liver cirrhosis exceeded essentially that of the healthy donors. It might be due either to the reduced number or decreased function bone marrow suppressor cells in liver cirrhosis. These patients' peripheral blood lymphocytes under in vitro conditions as well as the healthy donors' lymphocytes did not produce any suppressive effect.
D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001853:Bone Marrow / Q000276:immunology*; D002455:Cell Division; D002478:Cells, Cultured; D002908:Chronic Disease; D006506:Hepatitis A / Q000150:complications* / Q000276:immunology; D006509:Hepatitis B / Q000150:complications* / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology / Q000276:immunology*; D008104:Liver Cirrhosis, Alcoholic / Q000276:immunology*; D008297:Male; D051379:Mice; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000914:Antibodies, Viral; D006514:Hepatitis B Surface Antigens
Kostnomozgovye kletki-supressory u bol'nykh virusnymi i alkogol'nymi tsirrozami pecheni.