[Removal of lipoprotein complexes of cholesterol from plasma using silochromes].
Industrial silicates, silochromes, proved to be effective sorbents of cholesterol lipoprotein complexes in blood in vitro. Silochrome SH-1.5 with a diameter of pores of 180-200 nm and a capacity of 12-14 mg of cholesterol per 1 g of the sorbent exhibited the best efficiency in isolation of the complexes. At the same time, maximal unspecific binding of blood plasma proteins was observed in the systems with silochrome SH-3 with a diameter of pores of 60 nm. By use of silochrome SH-1.5 for plasmosorption the content of cholesterol was decreased from 3,600 mg/l down to 2,150 mg/l, i.e. by 40%, in blood plasma of a rabbit with experimental hypercholesterolemia.
D000818:Animals; D002784:Cholesterol / Q000097:blood* / Q000302:isolation & purification; D008078:Cholesterol, LDL / Q000097:blood / Q000302:isolation & purification; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D008074:Lipoproteins / Q000097:blood* / Q000302:isolation & purification; D011817:Rabbits; D058428:Silica Gel; D012822:Silicon Dioxide
D008078:Cholesterol, LDL; D008074:Lipoproteins; D058428:Silica Gel; D012822:Silicon Dioxide; D002784:Cholesterol
Udalenie lipoproteidnykh kompleksov kholesterina iz plazmy krovi s ispol'zovaniem silokhromov.