title: Inactivation and partition of human T-cell lymphotrophic virus, type III, during ethanol fractionation of plasma.
abstract: Because of concern about the safety of immune globulins prepared for injection, we studied the effects of ethanol fractionation of human plasma on human lymphotropic virus, type III, (HTLV-III) by spiking the products of various fractionation steps with HTLV-III. Tests of inactivation and removal indicated that the ratio of residual live virus in plasma fractions/live virus in starting plasma was about 1 X 10(-15) for precipitate II from which immune globulin for injection is manufactured. The results are reassuring regarding the potential safety of immune globulin.
mesh_terms: D017977:Deltaretrovirus / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D007136:Immunoglobulins / Q000302:isolation & purification*; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects
chemical_list: D007136:Immunoglobulins; D000431:Ethanol