Identification of high levels of protein phosphatase-1 in rat liver nuclei.
Rat liver nuclei contain a protein phosphatase that is indistinguishable from the catalytic subunit of protein phosphatase-1 in its molecular mass, sensitivity to inhibitor-1 and inhibitor-2 and specificity for the beta-subunit of phosphorylase kinase. This activity is not bound to the outer nuclear membrane, but located within the nucleus. The average level of protein phosphatase-1 activity in nuclei is at least 5-fold higher than its average extranuclear concentration.
D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology; D000242:Cyclic AMP / Q000502:physiology; D005260:Female; D008099:Liver / Q000201:enzymology*; D010749:Phosphoprotein Phosphatases / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000378:metabolism; D010765:Phosphorylase Phosphatase / Q000032:analysis; D011494:Protein Kinases / Q000032:analysis; D054645:Protein Phosphatase 1; D051381:Rats; D011919:Rats, Inbred Strains
D000242:Cyclic AMP; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases; D054645:Protein Phosphatase 1; D010765:Phosphorylase Phosphatase