Vasopressin and oxytocin reduce plasma prolactin levels of conscious rats in basal and stress conditions. Study of the characteristics of the receptor involved.
Subcutaneous administration of arginine vasopressin (AVP) to conscious rats induced a dose-dependent increase of plasma ACTH and beta-endorphin levels and decrease of plasma prolactin (PRL) levels 30 min later. AVP similarly reduced PRL increase induced by exposure to a novel environment stress. Oxytocin (OT) was also active but 5-fold less potent than AVP. The study of several analogs with specific agonistic and antagonistic activity on the oxytocic, vasopressor and antidiuretic receptors of OT and AVP suggests that the receptor involved in this effect does not fit into this classification.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology*; D003894:Deamino Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000097:blood; D008297:Male; D010121:Oxytocin / Q000031:analogs & derivatives / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000097:blood*; D013329:Structure-Activity Relationship; D001615:beta-Endorphin
D004723:Endorphins; D001127:Arginine Vasopressin; C047063:oxytocin, Phe(2)-Orn(8)-; D010121:Oxytocin; C007223:vasopressin, 1-deamino-4-Val-8-Arg-; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D003894:Deamino Arginine Vasopressin