Immunomodulation in offspring mice after neonatal immunostimulation of mothers or newborn mice.
Mothers of offspring Balb/c mice were stimulated after birth by two substances, a bacterial lysate (LAB) and a chemical, diethyldithiocarbamate (DETC). Anti-sheep red blood cell (SRBC) antibodies were studied after immunization of stimulated mothers or offspring. An increase of anti-SRBC was observed in LAB-stimulated mothers, but these antibodies were decreased in their offspring before weaning. Sometimes, these antibodies were increased in LAB-stimulated newborn mice. DETC stimulation of mothers induced an elevation of antibody response in mothers and newborns. The same results were obtained in previous investigations where the pregnant mother was stimulated with the same agents.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000906:Antibodies / Q000032:analysis; D001419:Bacteria; D002457:Cell Extracts; D004050:Ditiocarb / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007114:Immunization; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D012756:Sheep / Q000276:immunology; D000095983:Bacterial Lysates
D000276:Adjuvants, Immunologic; D000906:Antibodies; D002457:Cell Extracts; D004050:Ditiocarb; C030259:Broncho-Vaxom; D000095983:Bacterial Lysates