Comparison of susceptibilities of varicella-zoster virus and herpes simplex viruses to nucleoside analogs.
The susceptibilities of varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) to 17 nucleoside analogs were compared by a plaque reduction assay with human embryonic lung fibroblast cells. The susceptibility of VZV to certain nucleoside analogs was different from that of HSV-1. Against VZV the 5-halogenovinyl-arabinosyluracils were the most potent of the compounds tested.
D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D014645:Herpesvirus 3, Human / Q000187:drug effects*; D006801:Humans; D009705:Nucleosides / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects*; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D009705:Nucleosides