[Effect of a highly dispersed zinc powder on the cAMP phosphodiesterase activity in mouse thymocytes].
The inhibition of cAMP phosphodiesterase activity by high dispersed zinc powder and zinc ions has been found in vitro experiments. The enzyme activity dependence on concentration of inhibitors is characterized by sigmoidal curve with Hill coefficients 1,8-2,1 and 1,2-1,3 correspondingly that may indicate the presence of positive cooperativity on inhibitor in enzyme. Magnesium ions influence the inhibited effect of zinc ions and the preparation of high dispersed zinc powder.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011208:Powders; D013950:Thymus Gland / Q000187:drug effects* / Q000201:enzymology; D015032:Zinc / Q000494:pharmacology*
D011208:Powders; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D008274:Magnesium; D015032:Zinc
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