omega-Iodophenyl fatty acids: a convenient method of radioiodination.
A solid-phase radioiodination technique for omega-iodophenyl fatty acids using ammonium sulfate is described. The radioiodinations are regioselective, high in yield (95%), short in reaction time (1 h) and capable of yielding high specific activity products although at lower yields. Purification is exceptionally simple: a single passage through an ion exchange column to remove unreacted I- is all that is required. Syntheses of several omega-iodophenyl fatty acids are also described.
D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D007553:Isotope Labeling; D009206:Myocardium / Q000378:metabolism
D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes