Effect of ACTH-(4-10) on equilibrium compensation after unilateral labyrinthectomy in the squirrel monkey.
Daily injection of ACTH-(4-10) was given to squirrel monkeys for a 28 day period to modify the characteristics of the post-unilateral labyrinthectomy symptoms along the course of the equilibrium compensation. When compared to the results of the control group, the ACTH-(4-10) injection groups (daily dose 250 micrograms/kg or 500 micrograms/kg) showed a significant improvement of acquisition and maintenance of compensation both in the spinal locomotor balance function and the oculomotor balance function.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D007758:Ear, Inner / Q000601:surgery*; D005260:Female; D005684:Gait; D008297:Male; D009760:Nystagmus, Physiologic / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D004856:Postural Balance / Q000187:drug effects*; D012453:Saimiri
D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10)