Effects of L-carnitine administration on mitochondrial electron transport activity present in human muscle during circulatory shock.
Carnitine was administered to a group of patients in shock, and the activities of cytochrome oxidase and succinate cytochrome c reductase in muscle needle biopsies from these patients were compared to those activities present in a non-carnitine treated control group of patients. Carnitine seemingly exerted a significant protective action on cytochrome oxidase activity during the initial phases of shock, but not to such an extent on succinate cytochrome c reductase activities.
D002331:Carnitine / Q000494:pharmacology* / Q000627:therapeutic use; D004579:Electron Transport / Q000187:drug effects; D003576:Electron Transport Complex IV / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008931:Mitochondria, Muscle / Q000378:metabolism*; D009132:Muscles / Q000201:enzymology; D009245:NADH Dehydrogenase / Q000378:metabolism; D012769:Shock / Q000188:drug therapy / Q000378:metabolism*
D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV; D002331:Carnitine