[The role of membrane phosphoinositides in mediating hormonal effects].
The present notions on the pathways of phosphoinositide metabolism in a cell and on the functional significance of the given process are reported. The enzymic systems providing catabolism of phosphoinositides are analyzed. The data indicating the dose interrelation between the stimulation of the phosphatidyl inosite and polyphosphoinositides metabolism by hormones and the Ca2+ transport into a cell are generalized. Universality, biochemical mechanisms and functional significance of the "phosphatidyl inosite" response are discussed. The phosphoinositide metabolism is considered from the standpoint of its significance for other cell processes: synthesis of eicosanoids, provision of Ca2+-dependent processes in the synapse, cell proliferation, activation and the "anchoring" of enzymes on membranes.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism; D004537:Eicosanoic Acids / Q000096:biosynthesis; D006728:Hormones / Q000502:physiology*; D008563:Membrane Lipids / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological; D010716:Phosphatidylinositols / Q000378:metabolism* / Q000502:physiology; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism / Q000502:physiology; D010738:Type C Phospholipases / Q000378:metabolism
D004537:Eicosanoic Acids; D006728:Hormones; D008563:Membrane Lipids; D010716:Phosphatidylinositols; D011942:Receptors, Adrenergic, alpha; D010738:Type C Phospholipases; D002118:Calcium
Rol' membrannykh fosfoinozitidov v oposredovanii gormonal'nykh éffektov.