title: Structure and alpha-adrenergic activity of pyrazinimidazolines.
abstract: The effects of newly synthetized pyrazinimidazolines on the contraction of isolated rat tail artery and on the chronotropic action of rat atria as well as the effects on blood pressure in anaesthetized rats were determined. The structure-activity relationships were studied, including standard imidazoline drugs. Starting from practically inactive derivatives the step-by-step structural modifications have been made resulting in markedly active chemical congeners, which were designed, synthetized and tested pharmacologically.
mesh_terms: D000818:Animals; D001158:Arteries / Q000502:physiology; D016275:Atrial Function; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D013329:Structure-Activity Relationship; D013623:Tail; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D007093:Imidazoles; D011942:Receptors, Adrenergic, alpha