title: Characteristics and distribution of beta thalassemia haplotypes in South China.
abstract: Eleven restriction site polymorphisms in the beta-globin gene cluster were determined in 48 Chinese with homozygous beta-thalassemia and their parents. Seven haplotypes were identified as associated with the beta thal chromosome and 25 with the beta A chromosome. The distribution of the various beta thal haplotypes in different regions of South China was mapped and discussed in relation to prenatal diagnosis and migration of the Chinese people.
mesh_terms: D002681:China / Q000208:ethnology; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D004262:DNA Restriction Enzymes; D005260:Female; D008040:Genetic Linkage; D005914:Globins / Q000235:genetics*; D006720:Homozygote; D006723:Hong Kong; D006801:Humans; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013789:Thalassemia / Q000235:genetics*
chemical_list: D005914:Globins; D004262:DNA Restriction Enzymes