Penetration of sulbactam-ampicillin and clavulanic acid-amoxicillin into the pelvic peritoneum.
Sixteen patients were given single intravenous injections of ampicillin (0.5 g) with sulbactam (0.5 g), and 15 patients were given amoxicillin (1 g) with clavulanic acid (0.2 g) before elective laparoscopy. At 2 h after dosing, the concentrations of the four compounds in serum and in the peritoneal fluid from the Pouch of Douglas and the ratio of each combination reached levels shown to be effective for antimicrobial activity in vitro.
D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000378:metabolism*; D000667:Ampicillin / Q000008:administration & dosage / Q000378:metabolism*; D001202:Ascitic Fluid / Q000378:metabolism; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008875:Middle Aged; D010388:Pelvis; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000378:metabolism*; D010537:Peritoneum / Q000378:metabolism*; D013407:Sulbactam; D065093:beta-Lactamase Inhibitors
D002969:Clavulanic Acids; D065093:beta-Lactamase Inhibitors; D019818:Clavulanic Acid; D000667:Ampicillin; D000658:Amoxicillin; D010397:Penicillanic Acid; D013407:Sulbactam