Antitumor, antiviral and natural killer-inducing activities of human recombinant interferon-alpha in the guinea pig.
It was found that human recombinant interferon-alpha (Hu rIFN-alpha) was biologically active in the guinea pig. Namely, intratumor injection of either Hu rIFN-alpha A or A/D regressed tumors and prevented metastasis of guinea-pig line 10 tumor. These rIFNs augmented splenic natural killer activity of the guinea pig and reduced the cytopathic effect of virus on guinea-pig cells. Hu IFN-gamma showed no such activity.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D006168:Guinea Pigs; D007370:Interferon Type I / Q000494:pharmacology* / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000187:drug effects / Q000502:physiology*; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D011994:Recombinant Proteins / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology; D014721:Vesicular stomatitis Indiana virus
D000998:Antiviral Agents; D007370:Interferon Type I; D011994:Recombinant Proteins