Localization of multidrug resistance-associated DNA sequences to human chromosome 7.
Multidrug resistance in several human cell lines correlates with amplification or increased expression of two related DNA sequences, designated mdr1 and mdr2. These DNA sequences were used as probes for hybridization with DNA with a panel of human-mouse somatic cell hybrids and from individual human chromosomes separated by fluorescence-activated chromosome sorting. By these assays, both mdr1 and mdr2 sequences were localized to chromosome 7.
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D004247:DNA / Q000235:genetics*; D004262:DNA Restriction Enzymes; D004351:Drug Resistance; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D051379:Mice
D005819:Genetic Markers; D004247:DNA; D004262:DNA Restriction Enzymes