Characterization of ecotropic murine leukemia viruses in SJL/J mice.
Backcross mice assorting for the two ecotropic murine leukemia virus loci of SJL/J mice (Emv-9 and Emv-10) were tested for production of infectious leukemia viruses. It was found that tail tissue from mice carrying Emv-9 could not be induced to produce ecotropic MuLV whereas tail tissue from mice carrying Emv-10 were inducible. No mice showed detectable levels of spontaneous virus production. Preliminary restriction enzyme analyses indicated Emv-9 contains a deletion within the polymerase region.
D000818:Animals; D002478:Cells, Cultured; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005814:Genes, Viral; D009052:Leukemia Virus, Murine / Q000235:genetics* / Q000254:growth & development; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000382:microbiology*; D011995:Recombination, Genetic; D013623:Tail
D004279:DNA, Viral; D004262:DNA Restriction Enzymes