Cathepsin B and D, and Ca2+-dependent neutral protease activities in the retina of taurine-depleted rats.
Rats were treated with guanidinoethanesulfonic acid (GES), a taurine transport inhibitor, which reduces the tissue content of taurine. The quantity of taurine in the rat retinas after GES treatment was reduced by 46% after the first week, 60% after the second week, and 67% after the third week. Activities of cathepsin B and D were not significantly altered when calculated on the basis of either protein or DNA content in the taurine-depleted retinas. However, cytosolic Ca2+-dependent neutral protease activity in retinas from GES-treated rats increased by 55% after the third week.
D000818:Animals; D002154:Calpain / Q000378:metabolism*; D002401:Cathepsin B; D002402:Cathepsin D / Q000378:metabolism*; D002403:Cathepsins / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D013654:Taurine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D013997:Time Factors
D013654:Taurine; C009558:taurocyamine; D002403:Cathepsins; D002154:Calpain; D002401:Cathepsin B; D002402:Cathepsin D