Investigation of the role of ubiquinone in rat liver subcellular compartments.
The role of ubiquinone in the Golgi apparatus is still unknown, even if it might be considered as a lipid marker of the Golgi compartment because of its high content in these subcellular fractions. In vivo modulation of ubiquinone with ethanol and in vitro pentane extraction show that ubiquinone is not required either for NADH-ferricyanide reductase, acetaldehyde dehydrogenase activity, or Ca2+ and Mg2+ stimulated ATPases. Since ubiquinone does not seem to be involved in these enzymic activities in Golgi compartments, other possible functions are discussed, related to a role in membrane fluidity or as a barrier to the propagation of free radicals.
D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002458:Cell Fractionation; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006056:Golgi Apparatus / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010420:Pentanes; D010770:Phosphotransferases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000378:metabolism; D017855:Transferases (Other Substituted Phosphate Groups); D014451:Ubiquinone / Q000378:metabolism*
D010420:Pentanes; D014451:Ubiquinone; D000431:Ethanol; C033353:pentane; D000445:Aldehyde Oxidoreductases; C018699:aldehyde dehydrogenase (NAD(P)+); D009247:NADH, NADPH Oxidoreductases; C014227:ferricyanide reductase; D010770:Phosphotransferases; D017855:Transferases (Other Substituted Phosphate Groups); C037363:UDPgalactose - UDP-N-acetylglucosamine galactosephosphotransferase; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases