Comparative study of kinin destroying activity of blood enzymes in respiratory sarcoidosis patients.
A total of 192 patients with active sarcoidosis of the stages I and II were examined. The state of the kinin system of the blood was studied on the basis of the values of the rate of kininogenesis and kinin-destroying activity of the blood. The rate of kininogenesis was assessed by the content of kininogen and prekallikrein in the blood and by kallikrein activity. Antikinin potential was measured by the values of the activity of carboxypeptidase N (KI), angiotensin-converting enzyme (ACE) and total kininase activity (TKA) of the blood. KI and ACE were estimated by the rate of hydrolysis of synthetic substrates, TKA was estimated biologically by inactivation of the native substrate bradykinin. In sarcoidosis patients activation of the kinin system is detected which at early stages of the disease is accompanied by stimulation and later by depression of TKA. No correlation is found between values of KI, ACE and TKA. Possible mechanisms of these disturbances detected are discussed.
D002268:Carboxypeptidases / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D007705:Kinins / Q000097:blood*; D008168:Lung / Q000201:enzymology; D008171:Lung Diseases / Q000175:diagnosis / Q000201:enzymology*; D001121:Lysine Carboxypeptidase / Q000097:blood*; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D012507:Sarcoidosis / Q000175:diagnosis / Q000201:enzymology*
D007705:Kinins; D002268:Carboxypeptidases; D007703:Peptidyl-Dipeptidase A; D001121:Lysine Carboxypeptidase