Abnormal essential fatty acid composition of tissue lipids in genetically diabetic mice is partially corrected by dietary linoleic and gamma-linolenic acids.
Genetically diabetic mice (db/db) and their non-diabetic litter-mates were maintained for 15 weeks on diets supplemented with safflower oil or evening primrose (Oenothera bienis) oil, both essential fatty acid (EFA)-rich sources, or hydrogenated coconut oil (devoid of EFA). Plasma glucose was higher in the diabetic mice supplemented with the oils than in the unsupplemented diabetic mice. In the oil-supplemented non-diabetic mice, plasma glucose did not differ compared with the unsupplemented non-diabetic mice. The proportional content of arachidonic acid in the phospholipids of the pancreas was significantly decreased in diabetic mice, an effect which was completely prevented by supplementation with safflower or evening primrose oil but not hydrogenated coconut oil. In the liver phospholipids of the diabetic mice, dihomo-gamma-linolenic acid was proportionally increased, an effect reduced by supplementation with safflower oil but not evening primrose or hydrogenated coconut oils. In the liver triglycerides of the diabetic mice, gamma-linolenic acid, dihomo-gamma-linolenic acid and arachidonic acid were all proportionally decreased, effects which were also prevented by safflower or evening primrose oil but not hydrogenated coconut oil. Alopecia and dry scaly skin were prominent in the diabetic mice but less extensive in the diabetic mice supplemented with EFA.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D003920:Diabetes Mellitus / Q000378:metabolism*; D005228:Fatty Acids, Essential / Q000032:analysis*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology*; D008042:Linolenic Acids / Q000494:pharmacology*; D008055:Lipids / Q000032:analysis*; D008099:Liver / Q000032:analysis; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size; D010179:Pancreas / Q000032:analysis; D010743:Phospholipids / Q000032:analysis; D012867:Skin / Q000473:pathology; D014280:Triglycerides / Q000032:analysis; D017965:gamma-Linolenic Acid
D001786:Blood Glucose; D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D008042:Linolenic Acids; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D017965:gamma-Linolenic Acid; D019787:Linoleic Acid