[Pathogenetic correlation between chronic pancreatitis and pancreatic carcinoma].
The autopsy material from the Institute of Pathology of the Faculty of Medicine of the Humboldt University (Charité) in Berlin for the years 1970 to 1984 was analyzed with respect to the presence of pancreatic carcinoma and a long history of chronic, non-obstructive pancreatitis. A total of 20,515 adult sections were reviewed. 331 (1.6%) of these had carcinoma of the exocrine pancreas. 75 pancreata were dissected in tail-to-head direction into 10 blocks. In 12 (16%) of them a chronic non-obstructive pancreatitis or pancreatic scarring as a result of pancreatitis could be demonstrated histologically. The possibility of a relationship between pancreatitis and pancreatic carcinoma is considered, in particular with respect to pre-malignant changes and latency of the latter. Comprehensive analysis and evaluation of the present study material, together with a critical evaluation of the literature, support the viewpoint that long-term, chronic pancreatitis and pancreatic carcinoma have a common pathogenic basis and that chronic pancreatitis may be regarded as an antecedent event for the neoplasm.
D002288:Adenocarcinoma, Mucinous / Q000209:etiology / Q000473:pathology; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000209:etiology* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000209:etiology* / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000209:etiology / Q000473:pathology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000209:etiology* / Q000473:pathology; D010195:Pancreatitis / Q000150:complications* / Q000473:pathology
Uber pathogenetische Wechselbeziehungen zwischen chronischer Pankreatitis und Pankreaskarzinom.