title: [Nicotinamide coenzyme levels and activity of enzymes of their biosynthesis and degradation in animal tissues after exposure to extreme conditions and pathogenic factors].
abstract: Studies of enzymic systems of biosynthesis and decay of nicotinamide coenzymes under the effect of extremal and pathogenic factors have shown that the activation of enzymes of the nucleosidase cleavage of coenzymes is the most essential link in the mechanism of concentration disturbance of metabolically active vitamin PP forms under cooling and development of inflammatory processes in the myocardium and liver. Inhibition of the enzymic activity in the biosynthesis of coenzymes under allergic myocarditis and hepatitis may play a definite role in the mechanism of disturbance of the coenzymic function of vitamin PP.
mesh_terms: D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology; D003067:Coenzymes / Q000378:metabolism*; D003080:Cold Temperature / Q000009:adverse effects; D007700:Kinetics; D009205:Myocarditis / Q000201:enzymology / Q000276:immunology; D009536:Niacinamide / Q000378:metabolism*; D009612:Nicotinamide-Nucleotide Adenylyltransferase / Q000378:metabolism*; D009713:Nucleotidyltransferases / Q000378:metabolism*; D010770:Phosphotransferases / Q000378:metabolism*; D017853:Phosphotransferases (Alcohol Group Acceptor); D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003067:Coenzymes; D009536:Niacinamide; D010770:Phosphotransferases; D017853:Phosphotransferases (Alcohol Group Acceptor); C021844:NAD kinase; D009713:Nucleotidyltransferases; D009612:Nicotinamide-Nucleotide Adenylyltransferase
vernacular_title: Uroven' nikotinamidnykh kofermentov i aktivnost' fermentov ikh biosinteza i raspada v tkaniakh zhivotnykh pri vozdeĭstvii ékstremal'nykh i patogennykh faktorov.