title: Chemical modification of adrenal response to external whole body irradiation in mice.
abstract: Adult Swiss albino mice were exposed to whole body gamma irradiation with 1.5, 3.0, 6.0 and 9.0 Gy in the presence or absence of the protective drugs MPG and WR-2721. The changes in the total cell population, pyknotic nuclei and necrotic cells, and binucleate cells were observed at various post-irradiation times. The degree of damage increased with the radiation dose. The number of total cells decreased with a corresponding increase in pyknotic nuclei, necrotic cells and binucleate cells. Both drugs provided protection against radiation injury, and reduced early post-irradiation cell damage and enhanced recovery after sublethal exposures. After higher doses, especially after lethal doses, the drugs became less effective in protecting the tissue.
mesh_terms: D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects*; D004999:Amifostine / Q000494:pharmacology*; D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D002467:Cell Nucleus / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D051379:Mice; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D008625:Tiopronin / Q000494:pharmacology*; D014916:Whole-Body Irradiation
chemical_list: D000603:Amino Acids, Sulfur; D009946:Organothiophosphorus Compounds; D008625:Tiopronin; D004999:Amifostine