T lymphocyte responses to Coxsackie B4 and mumps virus. I. Influence of HLA-DR restriction elements.
The proliferative T lymphocyte responses to Coxsackie B4-, mumps- and varicella-zoster viral antigens were characterized. No significant difference in responsiveness was found between healthy individuals and patients with Type 1 (insulin-dependent) diabetes mellitus. Theophyllamine and verapamil decreased antigen-stimulated proliferation, whereas indomethacin in physiologic concentrations (1 microgram/ml) slightly increased proliferation. A major part of the response seemed to be restricted by HLA-DR molecules. Furthermore, for the mumps antigen the DR3- and DR4-determinants which are associated with Type 1 diabetes, seemed to have a different regulatory function on the T lymphocyte response in that an increased frequency of low responders was found among DR3 positive individuals and an increased frequency of high responders among DR4 positives.
D000628:Aminophylline / Q000494:pharmacology; D000956:Antigens, Viral / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D004770:Enterovirus / Q000276:immunology*; D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen; D014645:Herpesvirus 3, Human / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D009109:Mumps virus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014700:Verapamil / Q000494:pharmacology
D000956:Antigens, Viral; D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II; D000628:Aminophylline; D014700:Verapamil; D007213:Indomethacin