Immune responses to isolated human cytomegalovirus envelope proteins.
A group of envelope proteins of human cytomegalovirus, gA protein (L. Pereira, M. Hoffman, M. Tatsuno, and D. Dondero, Virology 139:73-86, 1984; L. Pereira, p. 383-404, in B. Roizman, ed., The herpesviruses, vol. 3, 1985), and two protein mixtures (58,000-molecular-weight [58K]-66K and 130K-66K), separated by serial columns prepared with anti-gA immunoglobulin G from sera of immunized guinea pigs, induced neutralizing antibodies and a cellular immune response in the animals. The gA is a disulfide-linked protein complex consisting of high-molecular-weight (greater than 200K), 130K-150K, and 55K-58K proteins.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D003587:Cytomegalovirus / Q000276:immunology*; D006168:Guinea Pigs; D006801:Humans; D007114:Immunization; D008213:Lymphocyte Activation; D008970:Molecular Weight; D009500:Neutralization Tests; D014759:Viral Envelope Proteins / Q000276:immunology* / Q000302:isolation & purification
D000914:Antibodies, Viral; D014759:Viral Envelope Proteins