title: Disorders of the pyruvate dehydrogenase complex.
abstract: Pyruvate dehydrogenase deficiency may be a non-specific consequence of many different neurological degenerative disorders. There are also serious methodological problems in estimating the activity of this enzyme complex.
mesh_terms: D000105:Acetyl Coenzyme A / Q000378:metabolism / Q000494:pharmacology; D000123:Acetyltransferases / Q000172:deficiency / Q000378:metabolism; D000138:Acidosis / Q000209:etiology; D001921:Brain / Q000473:pathology; D002245:Carbon Dioxide / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003065:Coenzyme A / Q000494:pharmacology; D003391:Cranial Nerves / Q000002:abnormalities; D008058:Dihydrolipoamide Dehydrogenase / Q000172:deficiency / Q000378:metabolism; D051047:Dihydrolipoyllysine-Residue Acetyltransferase; D005147:Facial Bones / Q000002:abnormalities; D005246:Feedback; D006801:Humans; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D007888:Leigh Disease / Q000209:etiology; D008970:Molecular Weight; D009069:Movement Disorders / Q000209:etiology; D009243:NAD / Q000378:metabolism / Q000494:pharmacology; D009422:Nervous System Diseases / Q000209:etiology; D010744:Phosphoric Monoester Hydrolases / Q000172:deficiency; D011767:Pyruvate Decarboxylase / Q000032:analysis / Q000172:deficiency / Q000378:metabolism; D011768:Pyruvate Dehydrogenase Complex / Q000032:analysis / Q000378:metabolism; D015325:Pyruvate Dehydrogenase Complex Deficiency Disease; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D013053:Spectrophotometry
chemical_list: D007773:Lactates; D011768:Pyruvate Dehydrogenase Complex; D011773:Pyruvates; D009243:NAD; D002245:Carbon Dioxide; D019344:Lactic Acid; D000105:Acetyl Coenzyme A; D019289:Pyruvic Acid; D008058:Dihydrolipoamide Dehydrogenase; D000123:Acetyltransferases; D051047:Dihydrolipoyllysine-Residue Acetyltransferase; D010744:Phosphoric Monoester Hydrolases; D011767:Pyruvate Decarboxylase; D003065:Coenzyme A