title: Studies on the male antifertility agent gossypol acetic acid. VII. Effect of motility stimulated factors on the revival of human spermatozoal motility after gossypol treatment in vitro.
abstract: Human spermatozoa were incubated with gossypol acetic acid (100 micrograms/1 X 10(6) spermatozoa/ml) at 37 degrees C for 30 min. The drug treatment inhibited the spermatozoal motility significantly. Washing of the spermatozoa, after gossypol treatment, did not effect their motility. A partial revival in the motility of the spermatozoa was observed when gossypol treated spermatozoa were incubated, after washing, with motility stimulating factors, e.g. theophylline, dibutyryl-cAMP and Kallikrein.
mesh_terms: D003994:Bucladesine / Q000494:pharmacology; D006072:Gossypol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007610:Kallikreins / Q000494:pharmacology; D008297:Male; D013081:Sperm Motility / Q000187:drug effects*; D013806:Theophylline / Q000494:pharmacology
chemical_list: D003994:Bucladesine; D013806:Theophylline; D007610:Kallikreins; D006072:Gossypol; C028178:gossypol acetic acid