Differential effects of morphine on the rates of dopamine turnover in the neural and intermediate lobes of the rat pituitary gland.
The acute administration of morphine to male rats decreased the rate of dopamine turnover in the median eminence and in the neural lobe of the pituitary, but was without effect in the intermediate lobe of the pituitary. Pretreatment with the opiate antagonist, naltrexone, reduced the effects of morphine. These results indicate that morphine, by acting on opiate receptors, inhibits the activity of tuberoinfundibular dopaminergic neurons that terminate in the median eminence and those tuberohypophysial dopaminergic neurons that terminate in the neural lobe of the pituitary.
D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008473:Median Eminence / Q000187:drug effects / Q000378:metabolism; D008781:Methyltyrosines / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology*; D009271:Naltrexone / Q000494:pharmacology; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D010904:Pituitary Gland, Posterior / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology; D019805:alpha-Methyltyrosine
D008781:Methyltyrosines; D011957:Receptors, Opioid; D009271:Naltrexone; D019805:alpha-Methyltyrosine; D009020:Morphine; D004298:Dopamine