Biodegradation of polyglycolic acid in bone tissue: an experimental study on rabbits.
The biodegradation of polyglycolic acid (PGA) was investigated in cortical bone of 21 rabbits and in cancellous bone of 15 rabbits. The follow-up times were 3, 6, and 12 weeks. Radiographical, histological, microradiographical, and oxytetracycline labeling studies were done. PGA was biocompatible and was degraded to a great extent in the cancellous bone and partly in the cortical bone in 12 weeks without any sign of inflammation or foreign body reaction. The biodegradation of PGA started peripherally in the area of the implant and continued with subsequent replacement by new bone.
D000818:Animals; D001673:Biodegradation, Environmental; D001842:Bone and Bones / Q000033:anatomy & histology / Q000378:metabolism*; D005453:Fluorescence; D011100:Polyglycolic Acid / Q000378:metabolism*; D011817:Rabbits; D013997:Time Factors
D011100:Polyglycolic Acid