[Mechanism of action of aldosterone on the toad bladder: correlation between biological response and occupation of the receptor sites].
The mechanism of aldosterone uptake in the epithelial cells of toad bladder was studied using mathematical modeling. It seems that two types of receptors are necessary to obtain a complete action of aldosterone. If this observation is confirmed, the traditional notion of type I receptors i.e. mineralocorticoids receptors and type II receptors i.e. glucocorticoids receptors has to be reviewed.
D000450:Aldosterone / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D002024:Bufo marinus; D066298:In Vitro Techniques; D008433:Mathematics; D008954:Models, Biological; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D018161:Receptors, Mineralocorticoid; D011987:Receptors, Steroid / Q000378:metabolism*; D001743:Urinary Bladder / Q000187:drug effects*
D011965:Receptors, Glucocorticoid; D018161:Receptors, Mineralocorticoid; D011987:Receptors, Steroid; D000450:Aldosterone
Mécanisme d'action de l'aldostérone dans la vessie de crapaud: corrélation entre réponse biologique et occupation des sites récepteurs.