Demonstration of Epstein-Barr virus DNA in a previously healthy boy with fulminant hepatic failure.
A previously healthy 9-year-old boy died from acute liver failure during an acute Epstein-Barr virus infection. Epstein-Barr virus DNA could be demonstrated in the liver by Southern blot--and by in situ hybridization techniques. The identification of the virus in the liver suggests a causal relation between the Epstein-Barr virus and the acute massive liver cell necrosis.
D002648:Child; D004279:DNA, Viral / Q000032:analysis*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications*; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008107:Liver Diseases / Q000209:etiology* / Q000473:pathology; D008297:Male
D004279:DNA, Viral