K-26, a novel inhibitor of angiotensin I converting enzyme produced by an actinomycete K-26.
A novel inhibitor of angiotensin I converting enzyme (ACE), designated K-26, was isolated from the broth filtrate of an actiomycete K-26. K-26 is a water soluble, acidic peptide composed of an equal mol of L-isoleucine, L-tyrosine and 1(R)-1-amino-2-(4-hydroxyphenyl)-ethylphosphonic acid. The IC50 of K-26 for ACE inhibition was 6.7 ng/ml when hippuryl-L-histidyl-L-leucine was used as a substrate of ACE. K-26 possesses hypotensive activity in vivo.
D000192:Actinomycetales / Q000032:analysis*; D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D005285:Fermentation; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril