title: [Transposition and reversion of mutations induced in Drosophila by viral DNA].
abstract: Injection of solutions of highly polymerized DNA isolated from nuclear polyhedrosis virus of Galleria mellonella into adult males induced with a considerable frequency visible mutations, two of which were studied in detail. They were detected in about 30 000 flies in the progeny of treated males. Much less than Notched-wings much greater than (Ndw, chromosome 3, location 87.9, dominant) independently arose 12 times, much less than thickened-veins much greater than (thi, chromosome 2, location 71.4, recessive) independently arose 7 times. No mutations were detected in the control of the same size. It was found that both Ndw and thi mutations gave frequent transpositions and reversions in mature, immature germ cells and in somatic cells, in latter cases leading to mosaicism. These results demonstrate for the first time that mutations induced by exogenous DNA are capable of transposition and reversion.
mesh_terms: D000818:Animals; D004251:DNA Transposable Elements; D004279:DNA, Viral / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D005838:Genotype; D007304:Insect Viruses / Q000235:genetics; D009154:Mutation; D014162:Transfection
chemical_list: D004251:DNA Transposable Elements; D004279:DNA, Viral
vernacular_title: Transpozitsii i reversii mutatsiĭ drozofily, indutsirovannykh virusnoĭ DNK.