title: Effects of irradiation and inhibition of adenosine diphosphate ribosyl transferase in radiation sensitive and resistant mouse lymphoma (L5178Y) cells.
abstract: The effects of treatment with benzamide, an inhibitor of adenosine diphosphate (ADP) ribosyl transferase, were studied in two strains of L5178Y lymphoma cells of differential sensitivity to ionizing radiation. Continuous 2 mmol/l benzamide treatment enhanced the killing effect of roentgen irradiation in the sensitive cells, but not in the resistent cells. Three hours' treatment with 2 to 15 mmol/l benzamide sensitized irradiated cells of both strains to a similar extent. Rejoining of DNA breaks was delayed by 2 mmol/l benzamide in sensitive cells more than in resistant cells.
mesh_terms: D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D002478:Cells, Cultured; D004260:DNA Repair / Q000187:drug effects; D007940:Leukemia L5178; D051379:Mice; D011836:Radiation Tolerance
chemical_list: D001549:Benzamides