A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family.
A new acute transforming feline retrovirus, the Hardy-Zuckerman 4 feline sarcoma virus (HZ4-FeSV), has been isolated from a feline fibrosarcoma. The viral genome of HZ4-FeSV contains a new oncogene designated v-kit, has the structure 5' delta gag-kit-delta pol-delta env 3' and specifies a gag-kit polyprotein of relative molecular mass 80,000. The predicted kit amino-acid sequence displays partial homology with tyrosine-specific protein kinase oncogenes. HZ4-FeSV appears to have been generated by transduction of feline c-kit sequences with feline leukaemia virus.
D000595:Amino Acid Sequence; D001483:Base Sequence; D002472:Cell Transformation, Viral; D015683:Gene Products, gag; D005796:Genes; D008970:Molecular Weight; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D009857:Oncogenes; D011494:Protein Kinases / Q000235:genetics*; D011519:Proto-Oncogenes; D011995:Recombination, Genetic; D012190:Retroviridae / Q000235:genetics*; D012191:Retroviridae Proteins / Q000235:genetics; D005253:Sarcoma Viruses, Feline / Q000235:genetics*
D015683:Gene Products, gag; D009856:Oncogene Proteins, Viral; D012191:Retroviridae Proteins; D011494:Protein Kinases