Enhancement of methotrexate cytotoxicity by uracil analogues that inhibit deoxyuridine triphosphate nucleotidohydrolase (dUTPase) activity.
D000818:Animals; D002417:Cattle; D002453:Cell Cycle / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis / Q000378:metabolism; D045647:DNA Glycosylases; D006801:Humans; D066298:In Vitro Techniques; D008727:Methotrexate / Q000633:toxicity*; D051379:Mice; D009699:N-Glycosyl Hydrolases / Q000378:metabolism; D011755:Pyrophosphatases / Q000037:antagonists & inhibitors*; D013942:Thymine Nucleotides / Q000378:metabolism; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology; D051981:Uracil-DNA Glycosidase
D013942:Thymine Nucleotides; D014498:Uracil; D004247:DNA; D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases; D051981:Uracil-DNA Glycosidase; D011755:Pyrophosphatases; C020020:dUTP pyrophosphatase; C024157:thymidine 5'-triphosphate; D008727:Methotrexate