[Radioimmunologic evaluation of the prognosis and effective therapy of patients with small cell lung cancer].
Radioimmunoassay was used to determine CEA, ACTH, calcitonin (CT), parathyroid hormone (PTH) and cortisol levels in the blood plasma and serum of small-cell lung carcinoma patients before and after chemotherapy. The prognostic value of the determination of CEA, ACTH and CT levels was shown. In 74% of patients, progression of the disease was accompanied by a rise of the CEA level, successful treatment by a decrease in the CEA level. A similar correlation between tumor activity and ACTH, CT and PTH levels was shown in 50.44 and 47% of the patients respectively.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002116:Calcitonin / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000097:blood* / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D011379:Prognosis; D011863:Radioimmunoassay
D002272:Carcinoembryonic Antigen; D010281:Parathyroid Hormone; D004317:Doxorubicin; D003520:Cyclophosphamide; D000324:Adrenocorticotropic Hormone; D002116:Calcitonin; D006854:Hydrocortisone; D008727:Methotrexate
Radioimmunologicheskaia otsenka prognoza i éffektivnosti terapii bol'nykh melkokletochnym rakom legkogo.