Murine thymocytes mediate a natural killer-like activity against herpes virus-infected target cells but not YAC-1 target cells.
In this report, we demonstrated a natural killer (NK)-like activity against HSV-1 infected cells mediated by CD-1 mouse thymocytes. This cytolytic activity is specific for HSV-1-infected MCN cells, since both uninfected MCN and YAC-1 target cells are not susceptible to thymocyte lysis. Antibody plus complement depletion experiments indicate that a portion of the activity is associated with the Lyt 2-/L3T4- thymocyte subpopulation. This NK-like activity cannot be enhanced by addition of interleukin 2 in vitro.
D000818:Animals; D000950:Antigens, Ly / Q000276:immunology; D000961:Antilymphocyte Serum / Q000502:physiology; D002460:Cell Line; D003165:Complement System Proteins; D003602:Cytotoxicity, Immunologic; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D018139:Simplexvirus / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000950:Antigens, Ly; D000961:Antilymphocyte Serum; D003165:Complement System Proteins