Long-term effects of chemotherapy on lymphocyte chromosomes from patients treated for gestational trophoblastic tumours.
A cytogenetic follow-up study of patients treated with chemotherapy for gestational trophoblastic tumours was undertaken. In some cases, high levels of chromosome damage were found to persist in lymphocytes for several years after completion of therapy. These results are compared with those found in similar studies of non-malignant and other malignant diseases. The relevance of these findings to the risk of subsequent chemotherapy-induced malignancy is discussed.
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D011247:Pregnancy; D012306:Risk; D013997:Time Factors; D014328:Trophoblastic Neoplasms / Q000188:drug therapy / Q000235:genetics*; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000235:genetics*
D000970:Antineoplastic Agents