Plaque enhancement effect of sodium thiosulfate for foot-and-mouth disease viruses.
A plaque enhancement effect by the addition of sodium thiosulfate for foot-and-mouth disease viruses was demonstrated when this salt was incorporated in agar and in agarose overlay media. Most of the mechanism is obscure, however, as one of the effects is that sodium thiosulfate seems to interact in a reversible manner against the plaque inhibitor action of neutral red in cellular cytoplasm. A plaque inhibitor contained in agar could be removed in some degree by the addition of this salt.
D000362:Agar; D000818:Animals; D005537:Aphthovirus / Q000187:drug effects* / Q000254:growth & development; D002460:Cell Line; D003470:Culture Media; D012703:Serotyping; D013885:Thiosulfates / Q000494:pharmacology*; D010948:Viral Plaque Assay
D003470:Culture Media; D013885:Thiosulfates; D000362:Agar; C017717:sodium thiosulfate