Retrovirus-induced osteopetrosis in mice. Ultrastructural evidence of early virus production in osteoblasts and osteocytes.
Newborn female strain NMRI mice were given injections of a mouse retrovirus (OA MuLV) known to induce osteopetrosis, osteoma, and lymphoma. Femur metaphyses and lumbar vertebrae were investigated ultrastructurally 3 d, 7 d and 28 d after infection. Budding, immature and mature virus was observed associated with osteoblasts and osteocytes, but not with osteoclasts or chondrocytes, 28 d after infection with the virus. No production of virus particles was observed in bone-tissue in mock-treated controls. Thus, the primary target cell for OA virus in bone appears to belong to the osteoblastic/osteocytic cell lineage.
D000818:Animals; D005260:Female; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure*; D051379:Mice; D008854:Microscopy, Electron; D010006:Osteoblasts / Q000382:microbiology*; D010011:Osteocytes / Q000382:microbiology*; D010022:Osteopetrosis / Q000209:etiology* / Q000473:pathology; D012190:Retroviridae; D014412:Tumor Virus Infections / Q000648:ultrastructure*