Blood coagulation activities of the root extracts of Fagara xanthoxyloides plant.
The coagulant properties of root bark and root wood extracts of Fagara xanthoxyloides lam plant are reported. Results of an earlier report which showed that the aqueous extract of the root shortened both the PT and PTT of normal and FVIIIC-deficient plasma are confirmed as well as the absence of many such effects on FIXC-deficient plasma. Root bark manifested twice as much potency as an equal concentration of root wood. The activity could still be demonstrated in the residue of root bark after the lyophilized aqueous extract had been successively extracted with methanol and hexane. It is suggested that these results may have clinical implications.
D001777:Blood Coagulation / Q000187:drug effects*; D005164:Factor IX / Q000502:physiology; D005169:Factor VIII / Q000502:physiology; D006801:Humans; D010314:Partial Thromboplastin Time; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal
D010936:Plant Extracts; D005169:Factor VIII; D005164:Factor IX