Selective acrylamide-induced degeneration of color opponent ganglion cells in macaques.
P beta (color opponent) retinal ganglion cells in macaques were found to degenerate as a result of oral administration of acrylamide. Histological examination, wheat germ agglutinin-horseradish peroxidase transport and cytochrome oxidase histochemistry indicate that other retinal ganglion cells and other neurons in the visual pathways were spared.
D020106:Acrylamide; D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D003576:Electron Transport Complex IV / Q000378:metabolism; D005829:Geniculate Bodies / Q000187:drug effects; D008254:Macaca nemestrina; D012160:Retina / Q000187:drug effects*; D012165:Retinal Ganglion Cells / Q000187:drug effects* / Q000201:enzymology; D014793:Visual Cortex / Q000187:drug effects; D014795:Visual Pathways / Q000187:drug effects* / Q000201:enzymology
D000178:Acrylamides; D020106:Acrylamide; D003576:Electron Transport Complex IV