title: The mRNA and RNA-copy pseudogenes encoding TM30nm, a human cytoskeletal tropomyosin.
abstract: We have determined the sequence of a 2.5 kb mRNA in human fibroblasts encoding a 248 amino acid cytoskeletal tropomyosin. The protein product of this mRNA is TM30nm, one of five tropomyosin-like proteins in human fibroblasts. The structural gene encoding this mRNA can also produce a 1.3 kb mRNA encoding a 285 amino acid skeletal muscle alpha-tropomyosin by tissue-specific alternative mRNA splicing. However, the multiple RNA-copy pseudogenes of this gene family are derived largely if not exclusively from transcripts processed according to the pattern observed in non-muscle cells.
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D005347:Fibroblasts / Q000378:metabolism; D005796:Genes; D006801:Humans; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics*; D012156:Reticulocytes / Q000378:metabolism; D014158:Transcription, Genetic; D014335:Tropomyosin / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D014335:Tropomyosin; D004262:DNA Restriction Enzymes