title: Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation.
abstract: The various subtypes of adrenergic receptors represent distinct structural entities which are coupled in different ways to two major transmembrane signalling systems, the adenylate cyclase and phosphatidyl-inositol pathways. Recent evidence suggests that the functional linkage of both beta and alpha 1-adrenergic receptors to their respective effector systems is regulated by covalent modification of the receptors by phosphorylation-dephosphorylation reactions. Receptor phosphorylation appears to lead to desensitization of the biological response to receptor stimulation. Several kinases including protein kinase A, protein kinase C and a cAMP independent kinase appear to participate in these reactions.
mesh_terms: D000263:Adenylate Kinase / Q000502:physiology; D000818:Animals; D002846:Chromatography, Affinity / Q000379:methods; D006224:Cricetinae; D000242:Cyclic AMP / Q000502:physiology; D003888:Desensitization, Immunologic; D019204:GTP-Binding Proteins / Q000502:physiology; D007545:Isoproterenol / Q000494:pharmacology; D008970:Molecular Weight; D010766:Phosphorylation; D011493:Protein Kinase C / Q000502:physiology*; D011494:Protein Kinases / Q000502:physiology*; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology; D010738:Type C Phospholipases / Q000502:physiology
chemical_list: D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP; D011494:Protein Kinases; D011493:Protein Kinase C; D000263:Adenylate Kinase; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins; D007545:Isoproterenol