The effects of cyclosporin A on the early responses of B and T cells to Epstein-Barr virus infection.
The immunosuppressive properties of the fungal metabolite Cyclosporin A (CsA) on the human lymphocyte response to the polyclonal B cell activator Epstein-Barr virus (EBV) in vitro were assessed. CsA showed both stimulatory and inhibitory effects on EBV-induced IgM secretion, the net effect being dependent on the dose of virus used. T cells were required for both these effects to occur. A model is proposed to account for the complex interactions of CsA in this system.
D000917:Antibody Formation / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D002478:Cells, Cultured; D003524:Cyclosporins / Q000494:pharmacology*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007165:Immunosuppression Therapy; D007700:Kinetics; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D003524:Cyclosporins; D007075:Immunoglobulin M