A possible association between HTLV-I and B-cell chronic lymphocytic leukemia in Jamaica.
Cell surface markers were determined in 10 patients with chronic lymphocytic leukemia (CLL) in Jamaica, an area endemic for the human T-cell leukemia/lymphoma virus (HTLV-I) and with a high positivity for HTLV-I antibody titers in CLL patients. The results demonstrated that the predominant cell phenotype in all patients was of B-cell origin. When surveyed for HTLV-I antibody, 3 out of 5 patients with B-CLL from this series were found positive. A possible association between HTLV-I and B-CLL is discussed.
D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes; D017977:Deltaretrovirus / Q000145:classification / Q000276:immunology*; D005260:Female; D006801:Humans; D007563:Jamaica; D007945:Leukemia, Lymphoid / Q000145:classification / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000951:Antigens, Neoplasm; D000954:Antigens, Surface