4-Aminopyridine induces expansion of cutaneous receptive fields of dorsal horn cells.
Systemic administration of 4-aminopyridine (4-AP) increased the size of the cutaneous receptive fields of 9 of the 15 dorsal horn cells tested. These receptive fields were on the feet and toes of the hind limbs of cats. Receptive field sizes increased with increasing doses of 4-AP. However, 4-AP administration did not change the responses of dorsal horn cells to graded mechanical stimuli administered near the centers of their receptive fields.
D015761:4-Aminopyridine; D000344:Afferent Pathways / Q000166:cytology; D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D005260:Female; D005528:Foot / Q000294:innervation; D008297:Male; D013116:Spinal Cord / Q000166:cytology*; D013997:Time Factors; D014110:Touch / Q000502:physiology
D000631:Aminopyridines; D015761:4-Aminopyridine