Atypical keloids after dermabrasion of patients taking isotretinoin.
Six patients underwent dermabrasion while on or having recently completed isotretinoin (Accutane) therapy. All patients developed keloids in atypical locations; the keloids eventually responded to topical or intralesional steroid therapy. Retinoids have a modulatory effect on connective tissue metabolism, including suppression of collagenase, which may enhance keloid formation. Dermabrasion should be delayed in those patients taking or recently on isotretinoin therapy.
D000152:Acne Vulgaris / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D000328:Adult; D003869:Dermabrasion / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015474:Isotretinoin; D007627:Keloid / Q000209:etiology*; D008297:Male; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors; D008875:Middle Aged; D014212:Tretinoin / Q000009:adverse effects*
D014212:Tretinoin; D003012:Microbial Collagenase; D015474:Isotretinoin