An EEG investigation on nabilone, a synthetic cannabinoid, in rabbits.
In this paper, the electroencephalographic (EEG) and behavioural effects of nabilone, a derivative compound from delta 9-tetrahydrocannabinol (delta 9-THC), are studied in comparison with those of delta 8-tetrahydrocannabinol (delta 8-THC) in rabbits. The results show that nabilone requires lower doses than delta 8-THC to elicit cortical spike-and-wave complexes, but higher doses to disrupt hippocampal theta rhythm. These data are discussed in connection with the clinical actions of nabilone in man.
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004569:Electroencephalography; D011817:Rabbits; D013826:Theta Rhythm
D000932:Antiemetics; C011941:nabilone; C035731:delta-8-tetrahydrocannabinol; D013759:Dronabinol