Kidney Na,K-ATPase activity in streptozotocin-diabetic rats.
Measurements of the ouabain-sensitive Na,K-ATPase activity in the kidney was performed on female Wistar rats after 50 days' duration of diabetes, and compared to an age-matched control group. The measurements showed a 23% increase in the Na,K-ATPase activity per mg protein, and a 66% increase in the total Na,K-ATPase activity in the whole kidney. The increase Na,K-ATPase activity can be seen as a response to the increase in tubular sodium load which is a consequence of the increased glomerular filtration rate in diabetes.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D005260:Female; D007668:Kidney / Q000201:enzymology*; D009929:Organ Size; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D001786:Blood Glucose; D011506:Proteins; D000254:Sodium-Potassium-Exchanging ATPase