SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells.
SV40-virus-transformed human embryonal fibroblasts show an enhanced chemotactic response to the glycoprotein fibronectin. However, they recognize the same chemotactic active region as non-transformed fibroblasts. The result suggests that an enhancement of chemotaxis by fibroblasts which have been transformed with Simian Virus 40 is due not to the utilization of further chemotactic domains in the molecule, but to an increased sensitivity of the cells to the chemoattractant.
D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects*; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000502:physiology; D005353:Fibronectins / Q000494:pharmacology*; D006801:Humans; D010446:Peptide Fragments / Q000494:pharmacology; D013539:Simian virus 40 / Q000502:physiology*
D005353:Fibronectins; D010446:Peptide Fragments