Captopril in the hepatorenal syndrome.
Five patients with hepatorenal syndrome were treated with the orally active angiotensin-converting enzyme inhibitor captopril (25 or 50 mg 6 hourly) for up to 48 hours. Only one patient showed a significant increase in urinary sodium concentration (from less than 10 to 70 mmol/liter), but without associated diuresis; renal function continued to deteriorate in all patients with persistent oliguria and rising serum creatinine. The outcome was uniformly fatal. These results suggest that in the hepatorenal syndrome, captopril in standard dosage is without benefit, and provide further evidence that the changes in the renin-angiotensin system are probably secondary to reduced renal perfusion from some other cause.
D000328:Adult; D000450:Aldosterone / Q000097:blood; D000803:Angiotensin I / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007674:Kidney Diseases / Q000188:drug therapy* / Q000652:urine; D008107:Liver Diseases / Q000188:drug therapy* / Q000652:urine; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood; D012964:Sodium / Q000652:urine; D013577:Syndrome
D000806:Angiotensin-Converting Enzyme Inhibitors; D007457:Iodine Radioisotopes; D000804:Angiotensin II; D000450:Aldosterone; D000803:Angiotensin I; D002216:Captopril; D012964:Sodium; D003404:Creatinine; D012083:Renin