title: [Beta-endorphin and corticotropin in the blood of patients during the acute period of severe craniocerebral injury].
abstract: An increase in content of beta-endorphin simultaneously with either low or high concentrations of corticotropin were observed in blood of patients with critical craniocerebral injury at the first day of the trauma. The content of beta-endorphin was increased and the content of corticotropin was decreased in blood of the patients within one day after the surgical treatment of sub-, epi- and intracerebral hematomas. No correlation between contents of beta-endorphin and corticotropin was noted. The data obtained suggest existence of various pathways for regulation of beta-endorphin synthesis and secretion, which are independent from the corticotropin regulation processes.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D001930:Brain Injuries / Q000097:blood* / Q000188:drug therapy; D004723:Endorphins / Q000097:blood*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D013997:Time Factors; D001615:beta-Endorphin
chemical_list: D004723:Endorphins; D005938:Glucocorticoids; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone
vernacular_title: Beta-éndorfin i kortikotropin v krovi u bol'nykh v ostrom periode tiazheloĭ cherepno-mozgovoĭ travmy.