Persistence of virulent canine distemper virus in lymphoblastoid cell lines.
Persistent infection with virulent canine distemper virus (CDV-SH) was established in 2 human lymphoblastoid B cell lines (Wi-L2 and Raji), and one human (HSB), one simian (1670) and one canine (CT-45-S) lymphoblastoid T cell line. Cell free virus from persistently infected T cell lines was avirulent for dogs but virulence was maintained during 31 cell passages in persistently infected B cell lines.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D004216:Distemper / Q000473:pathology; D004217:Distemper Virus, Canine / Q000254:growth & development* / Q000302:isolation & purification / Q000472:pathogenicity; D004285:Dogs; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology*; D014774:Virulence; D014779:Virus Replication
D000914:Antibodies, Viral; D000956:Antigens, Viral