Search for 99mTc labeled DTS bifunctional radiopharmaceutical: role of functional groups in myocardial accumulation.
Development of 99mTc-bifunctional radiopharmaceutical (BR) is attracting the interest of various research groups. In the present paper, various molecules containing a neutral 99mTc-dithiosemicarbazone (DTS) structure as the technetium chelating site, along with various functional groups (amino, carboxyl or isobutyl group with diverse charge) are tested for their chemical or biological functions. The study on the effect of those functional groups is carried out in vitro and in vivo. The validity of introducing an amino group along with the technetium chelating site DTS for myocardial accumulation is discussed.
D000818:Animals; D051379:Mice; D008815:Mice, Inbred Strains; D009206:Myocardium / Q000378:metabolism*; D011854:Radiochemistry; D013329:Structure-Activity Relationship; D013667:Technetium / Q000378:metabolism*; D013882:Thiosemicarbazones / Q000378:metabolism*; D014018:Tissue Distribution
D013882:Thiosemicarbazones; C015848:dithiosemicarbazone; D013667:Technetium