Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region.
Demyelination induced by Theiler's virus was examined in mouse strains with congeneic recombinant haplotypes. Light and electron microscopy of spinal cord sections from mice with s, q, v, p, and f H-2D alleles showed perivascular inflammation and primary demyelination. The presence of susceptible haplotypes in the K or I region did not correlate with pathologic abnormalities. The Qa, Tla, PgK, and UpG genes did not appear to be critical in determining susceptibility to disease. However, mutation in the H-2D genes altered the susceptibility to virus-induced demyelination. B10.D2dm1 mice, which have deletions in the 3' end of Dd and the 5' end of Ld, showed prominent demyelination and clinical deficits. In contrast, BALB/c-dm2, which have a deletion of the entire L gene, showed no pathologic changes. Central nervous system virus titers correlated with susceptibility to demyelination; both resistant and susceptible strains had a strong humoral immune response to the virus. The findings in the congeneic recombinant mice and in mice mutant in the H-2D region strongly suggest that at least one of the genes critical for determining virus-induced demyelination maps to the 3' end of the H-2D gene.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral; D002490:Central Nervous System / Q000382:microbiology; D002874:Chromosome Mapping; D003711:Demyelinating Diseases / Q000235:genetics*; D004770:Enterovirus / Q000276:immunology; D004769:Enterovirus Infections / Q000235:genetics*; D005802:Genes, MHC Class II; D005838:Genotype; D006183:H-2 Antigens / Q000235:genetics*; D004680:Maus Elberfeld virus / Q000276:immunology; D051379:Mice; D009154:Mutation
D000914:Antibodies, Viral; D000956:Antigens, Viral; D006183:H-2 Antigens