title: Dual activation of the inositol-triphosphate-calcium and cyclic nucleotide intracellular signaling systems by adrenocorticotropin in rat adrenal cells.
abstract: Hormones which primarily utilize cAMP as their intracellular "second messenger" are generally not thought to activate the IP3-Ca++ signalling system. Presently, we show that ACTH, at certain concentrations, can activate both the cAMP and IP3-Ca++ intracellular signalling systems.
mesh_terms: D000311:Adrenal Glands / Q000502:physiology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000502:physiology*; D003345:Corticosterone / Q000096:biosynthesis; D000242:Cyclic AMP / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007295:Inositol Phosphates / Q000502:physiology*; D051381:Rats; D013403:Sugar Phosphates / Q000502:physiology*
chemical_list: D007295:Inositol Phosphates; D013403:Sugar Phosphates; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP; D002118:Calcium; D003345:Corticosterone