title: [Myasthenic syndromes linked to mediator secretion disorders].
abstract: On the basis of clinical and electrophysiological examinations of 23 patients with an impaired secretion of the mediator, the following 5 groups of patients with myasthenic syndromes (MS) characterized by disturbances of the neuromuscular transision were identified: patients with bronchogenic carcinoma of the lung; males with a clinical picture closely resembling the one described in bronchogenic cancer of the lung; young males and females with an abnormal thyroid gland; patients with a mild subcortical syndrome and with ataxia; patients with chronic botulinic intoxication. Correlation of the results of electrophysiological examination did not reveal any specificity for any of the identified groups of patients.
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000328:Adult; D001906:Botulism / Q000150:complications; D002283:Carcinoma, Bronchogenic / Q000503:physiopathology; D004576:Electromyography; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D011239:Prednisolone / Q000627:therapeutic use; D009435:Synaptic Transmission; D013577:Syndrome; D013959:Thyroid Diseases / Q000150:complications
chemical_list: D011239:Prednisolone; D000109:Acetylcholine
vernacular_title: Miastenicheskie sindromy, sviazannye s narusheniem sekretsii mediatora.