The importance of the Leydig cells in the vascular response to hCG in the rat testis.
The increase in permeability of the testicular blood vessels following an injection of hCG into rats is abolished completely if the animals are treated 3 days earlier with ethane dimethane sulphonate (EDS), a compound that effectively eliminates Leydig cells from the testes. As there is other evidence that androgens or prostaglandins are not involved in this vascular response, further studies will be necessary to determine whether these data mean that another vasoactive substance is secreted by the Leydig cells or whether the EDS also eliminates other cells besides the Leydig cells, for example the mast cells found in the vicinity of the testicular artery.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D007985:Leydig Cells / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008698:Mesylates / Q000494:pharmacology; D051381:Rats; D013737:Testis / Q000098:blood supply*; D013739:Testosterone / Q000097:blood
D006063:Chorionic Gonadotropin; D008698:Mesylates; D013739:Testosterone; C002994:ethylene dimethanesulfonate