title: Werner's syndrome associated with cholangiocarcinoma.
abstract: A 38-year-old Japanese man had cholangiocarcinoma in association with typical features of Werner's syndrome. The replicative capacity of fibroblasts in culture was characteristically reduced, and the in vitro natural killer cell activity was deficient. He died of massive G-I tract bleeding 8 months after admission.
mesh_terms: D002759:Adenoma, Bile Duct / Q000209:etiology*; D000328:Adult; D000375:Aging; D001650:Bile Duct Neoplasms / Q000209:etiology*; D002478:Cells, Cultured; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D009154:Mutation; D014898:Werner Syndrome / Q000150:complications* / Q000235:genetics