Membrane effects of ionizing radiation and hyperthermia.
Results of numerous studies demonstrate that membranes are important sites of cell damage by both ionizing radiation and hyperthermia. Modification of membrane properties (mainly lipid fluidity) affects the cellular responses to radiation and hyperthermia but former concepts that membrane rigidification sensitizes cells to radiation while membrane fluidization potentiates hyperthermic damage have now been seriously challenged. It seems that the effects of membrane fluidity on cell responses to hyperthermia and radiation are due to an indirect influence on functional membrane proteins. The major role of lipid peroxidation in radiation damage to membranes has also been questioned. The existing evidence makes it unlikely that the interaction between radiation and hyperthermia is determined by the action of both agents on the same membrane components.
D000818:Animals; D002152:Calorimetry, Differential Scanning; D002448:Cell Adhesion; D002462:Cell Membrane / Q000528:radiation effects*; D002463:Cell Membrane Permeability / Q000528:radiation effects; D000242:Cyclic AMP / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000528:radiation effects; D005334:Fever / Q000473:pathology*; D005454:Fluorescence Polarization; D006358:Hot Temperature; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism / Q000528:radiation effects; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000378:metabolism / Q000528:radiation effects; D008564:Membrane Potentials; D008565:Membrane Proteins / Q000378:metabolism / Q000528:radiation effects; D008954:Models, Biological; D008958:Models, Molecular; D011188:Potassium / Q000378:metabolism; D011975:Receptors, Mitogen / Q000378:metabolism
D008054:Lipid Peroxides; D008563:Membrane Lipids; D008565:Membrane Proteins; D011975:Receptors, Mitogen; D000242:Cyclic AMP; D011188:Potassium