title: Rates of membrane-associated reactions: reduction of dimensionality revisited.
abstract: The hypothesis that reactions associated with intracellular membranes enjoy a kinetic advantage from a reduced dimensionality for diffusion is inconsistent with available data on lateral diffusion rates, membrane-substrate affinities, and endogenous concentrations of enzymes and their aqueous substrates.
mesh_terms: D000818:Animals; D001435:Bacteriophages / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology*; D004058:Diffusion; D004798:Enzymes / Q000378:metabolism; D064429:Fatty Acid Synthases / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000502:physiology*; D007700:Kinetics; D008070:Lipopolysaccharides / Q000502:physiology; D008560:Membrane Fluidity; D008565:Membrane Proteins / Q000502:physiology*; D008962:Models, Theoretical; D010084:Oxidation-Reduction; D011336:Probability; D011956:Receptors, Cell Surface / Q000502:physiology; D011991:Receptors, Virus / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D004798:Enzymes; D008070:Lipopolysaccharides; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D011991:Receptors, Virus; D064429:Fatty Acid Synthases