Hit-and-run neutralization of poliovirus.
At physiological ionic strength, monoclonal antibody 35-1f4 has previously been shown to neutralize poliovirus type 1 by antibody-mediated polymerization. At low ionic strength, this antibody neutralized the virus by a hit-and-run mechanism: the virions were converted to non-infectious, empty capsids devoid of antibodies. These empty capsids resembled those formed by thermal denaturation of native polio virions in their sedimentation coefficient (80S), antigenicity (H) and isoelectric pH (6.3).
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D002213:Capsid / Q000276:immunology; D007526:Isoelectric Point; D009500:Neutralization Tests; D009994:Osmolar Concentration; D017955:Poliovirus / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral