[Changes in the biochemical parameters of lymphocyte functional activity in simian adenovirus SA7(C8)-induced carcinogenesis].
A functional defect of lymphocytes in hamsters with tumours during carcinogenesis induced by monkey adenovirus SA7(C8) was found and estimated by means of the blast transformation reaction. An increased activity of transport ATPases, the disturbance of cyclic nucleotide levels (cAMP, cGMP) and a decrease in both basal and Con A-activated calcium transportation were observed simultaneously with changes in the activation of immunocompetent cells under Con A influence.
D000256:Adenoviridae / Q000472:pathogenicity*; D000261:Adenoviruses, Simian / Q000472:pathogenicity*; D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000378:metabolism; D003208:Concanavalin A / Q000494:pharmacology; D006224:Cricetinae; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism; D005260:Female; D006393:Hemangiopericytoma / Q000209:etiology / Q000378:metabolism*; D008198:Lymph Nodes / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
D004273:DNA, Neoplasm; D003208:Concanavalin A; D000242:Cyclic AMP; D006152:Cyclic GMP; D002118:Calcium; D013936:Thymidine
Izmenenie nekotorykh biokhimicheskikh parametrov funktsional'noĭ aktivnosti limfotsitov pri kantserogeneze, indutsirovannom adenovirusom SA7(C8) obez'ian.