title: Flaviviridae.
abstract: The family Flaviviridae comprises the genus Flavivirus, which contains 65 related species and two possible members. They are small, enveloped RNA viruses (diameter 45 nm) with peplomers comprising a single glycoprotein E. Other structural proteins are designated C (core) and M (membrane-like). The single strand of RNA is infectious and has a molecular weight of about 4 X 10(6) and an m7G 'cap' at the 5' end but no poly(A) tract at the 3' end; it functions as the sole messenger. The gene sequence commences 5'-C-M-E.... The replication strategy and the mode of morphogenesis are distinct from those of the Togaviridae which are slightly larger and morphologically similar in some respects. Flaviviruses infect a wide range of vertebrates, and many are transmitted by arthropods.
mesh_terms: D000524:Alphavirus / Q000145:classification; D000818:Animals; D004721:Endoplasmic Reticulum / Q000382:microbiology / Q000648:ultrastructure; D005416:Flavivirus / Q000145:classification* / Q000235:genetics / Q000502:physiology / Q000648:ultrastructure; D005814:Genes, Viral; D009024:Morphogenesis; D012367:RNA, Viral / Q000096:biosynthesis / Q000235:genetics; D014758:Viral Core Proteins / Q000032:analysis; D014759:Viral Envelope Proteins / Q000032:analysis; D014763:Viral Matrix Proteins; D014764:Viral Proteins / Q000032:analysis / Q000096:biosynthesis; D014779:Virus Replication
chemical_list: D012367:RNA, Viral; D014758:Viral Core Proteins; D014759:Viral Envelope Proteins; D014763:Viral Matrix Proteins; D014764:Viral Proteins