Solid-phase peptide synthesis of human(Nle-27)-oxyntomodulin. Preliminary evaluation of its biological activities.
Oxyntomodulin is a peptide isolated from porcine intestine which consists of the whole glucagon sequence extended at its C-terminal part by a basic octapeptide. The analogue (Nle-27)-oxyntomodulin of the human sequence has been synthesized by solid-phase peptide synthesis, purified by HPLC and identified. Its biological activities are the same as those of the natural hormone.
D000595:Amino Acid Sequence; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005768:Gastrointestinal Hormones; D004763:Glucagon-Like Peptides / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D007202:Indicators and Reagents; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D053772:Oxyntomodulin; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism; D018027:Receptors, Glucagon; D013552:Swine
D005768:Gastrointestinal Hormones; D007202:Indicators and Reagents; D053772:Oxyntomodulin; D011956:Receptors, Cell Surface; D018027:Receptors, Glucagon; C048920:oxyntomodulin, Nle(27)-; D004763:Glucagon-Like Peptides