Liver-specific expression of a Qa-encoded class I gene is associated with DNA hypomethylation.
DNA methylation of two murine major histocompatibility complex (H-2) class I genes was examined in hybridizations to MspI and HpaII chromosomal DNA restriction digests. Q10, which exhibits liver-specific expression, and H-2Kb, a transplantation antigen gene, were examined in liver, spleen, thymus, and cell-line DNAs. Unmethylated Q10 gene sequences were detected only in the liver, whereas the H-2Kb gene was unmethylated in all tissues examined.
D000818:Animals; D002460:Cell Line; D004247:DNA / Q000235:genetics*; D004262:DNA Restriction Enzymes; D006649:Histocompatibility Antigens / Q000032:analysis; D008099:Liver / Q000276:immunology*; D008285:Major Histocompatibility Complex; D008745:Methylation; D051379:Mice; D009928:Organ Specificity; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
D006649:Histocompatibility Antigens; D004247:DNA; D004262:DNA Restriction Enzymes