1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice is enhanced by pretreatment with diethyldithiocarbamate.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004050:Ditiocarb / Q000633:toxicity*; D004298:Dopamine / Q000378:metabolism; D004357:Drug Synergism; D004409:Dyskinesia, Drug-Induced; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D009422:Nervous System Diseases / Q000139:chemically induced*; D011187:Posture; D011725:Pyridines / Q000633:toxicity*; D013859:Thiocarbamates / Q000633:toxicity*
D001679:Biogenic Amines; D011725:Pyridines; D013859:Thiocarbamates; D015102:3,4-Dihydroxyphenylacetic Acid; D004050:Ditiocarb; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine; D006719:Homovanillic Acid