Inherited complement component abnormalities.
Inherited deficiencies of early complement components are frequently associated with immune/rheumatic disorders and recurrent (Neisserial) infection with deficiency of late complement components. The genetic complexity of complement components is further demonstrated by electrophoretic allotypy and analysis of DNA restriction fragment length polymorphisms.
D000328:Adult; D000799:Angioedema / Q000235:genetics / Q000276:immunology; D002648:Child; D002874:Chromosome Mapping; D003167:Complement Activation; D003172:Complement C1 / Q000172:deficiency; D003175:Complement C2 / Q000172:deficiency; D003176:Complement C3 / Q000172:deficiency; D003181:Complement C4 / Q000172:deficiency; D003182:Complement C5 / Q000172:deficiency; D011415:Complement Factor B / Q000172:deficiency; D003165:Complement System Proteins / Q000172:deficiency* / Q000235:genetics; D004262:DNA Restriction Enzymes / Q000032:analysis; D004587:Electrophoresis, Agar Gel; D006680:HLA Antigens / Q000235:genetics; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007154:Immune System Diseases / Q000235:genetics / Q000276:immunology; D007239:Infections / Q000235:genetics / Q000276:immunology; D008297:Male; D008585:Meningitis, Meningococcal / Q000235:genetics / Q000276:immunology; D011110:Polymorphism, Genetic; D012216:Rheumatic Diseases / Q000235:genetics / Q000276:immunology
D003172:Complement C1; D003175:Complement C2; D003176:Complement C3; D003181:Complement C4; D003182:Complement C5; D006680:HLA Antigens; D003165:Complement System Proteins; D004262:DNA Restriction Enzymes; D011415:Complement Factor B