title: [Effect of thiamine on various types of synaptic junctions].
abstract: Thiamine (1.10(-14) -- 1.10(-4) mol/l) reversibly increased the frequency of miniature excitatory postsynaptic potentials, amplitude and quantal content of excitatory postsynaptic potentials in crayfish glutaminergic synapse. Thiamine also increased spontaneous electrical activity and amplitude of synaptic potentials in guinea-pig taenia coli. In synaptosomes from the rat brain thiamine produced depolarization of nerve endings. The role of thiamine in the regulation of synaptic transmission and mechanism of its action are discussed.
mesh_terms: D000818:Animals; D003400:Astacoidea; D001921:Brain / Q000187:drug effects*; D002432:Cecum / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009130:Muscle, Smooth / Q000294:innervation*; D009469:Neuromuscular Junction / Q000187:drug effects; D051381:Rats; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*; D013574:Synaptosomes / Q000187:drug effects; D013831:Thiamine / Q000494:pharmacology*
chemical_list: D013831:Thiamine
vernacular_title: Deĭstvie tiamina na razlichnye tipy sinapticheskikh soedineniĭ.