The effect of presynaptic receptor stimulation on adenosine 3',5'-cyclic monophosphate concentrations in rat cortical synaptosomes.
Changes in adenosine 3',5'-cyclic monophosphate (cAMP) concentration were measured in cortical synaptosomes. Preincubation with adenosine deaminase reduced cAMP concentration by 45%. Oxotremorine, clonidine, gamma-aminobutyric acid (GABA) and baclofen produced no change in basal concentration. 2-Chloroadenosine and noradrenaline (NA), acting at beta-adrenoceptors, both caused a dose-dependent increase in cAMP; the NA-stimulated increase was depressed by GABA and by baclofen.
D015762:2-Chloroadenosine; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D002540:Cerebral Cortex / Q000502:physiology*; D003000:Clonidine / Q000494:pharmacology; D000242:Cyclic AMP / Q000032:analysis*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010095:Oxotremorine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D013574:Synaptosomes / Q000032:analysis*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D017981:Receptors, Neurotransmitter; D015762:2-Chloroadenosine; D005680:gamma-Aminobutyric Acid; D010095:Oxotremorine; D000242:Cyclic AMP; D001418:Baclofen; D000241:Adenosine; D003000:Clonidine; D009638:Norepinephrine