[Effect of the catalytic subunit of cAMP-dependent protein kinase on the electrical activity of the rat heart in isadrine myocarditis].
The content of cAMP in the rat heart under neoepinephrine myocarditis does not differ from the control values and less increases relative to the control at the adrenalin concentrations of 5 X 10(-5) and 5 X 10(-4) M in the in vitro experiments (control: myocardium of healthy animals). Under these conditions dissociation of holoenzyme of cAMP-dependent protein kinase is disturbed in the presence of endogene-developed nucleotide and the phosphorylating activity decreases, respectively. The injection of the catalytic subunit of cAMP-dependent protein kinase encapsulated into neutral liposomes increases the duration of the myocarditis action potential for animals with the metabolic myocardial insufficiency.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006321:Heart / Q000503:physiopathology*; D007545:Isoproterenol / Q000633:toxicity; D008081:Liposomes / Q000008:administration & dosage; D008297:Male; D009205:Myocarditis / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D008081:Liposomes; D000242:Cyclic AMP; D011494:Protein Kinases; D007545:Isoproterenol
Vliianie kataliticheskoĭ sub''edinitsy cAMP-zavisimoĭ proteinkinazy na élektricheskuiu aktivnost' serdtsa krysy pri izadrinovom miokardite.