Cannabidiol attenuates delta 9-tetrahydrocannabinol-like discriminative stimulus effects of cannabinol.
Interaction effects of cannabidiol (CBD) and cannabinol (CBN) were examined using a drug discrimination procedure in which rats had been trained to discriminate between 3 mg/kg of delta 9-tetrahydrocannabinol (delta 9-THC) and vehicle (2 ml/kg). The generalization effects of CBN to delta 9-THC were attenuated when CBN was administered together with CBD. The results were time- and dose-dependent.
D000818:Animals; D002185:Cannabidiol / Q000494:pharmacology*; D002186:Cannabinoids / Q000494:pharmacology*; D002187:Cannabinol / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000494:pharmacology*; D004347:Drug Interactions; D005795:Generalization, Stimulus / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002186:Cannabinoids; D002185:Cannabidiol; D013759:Dronabinol; D002187:Cannabinol