A revised structure of the antitumor drug elliptinium--amino(acid) adducts.
Using simple organic reactions and spectrometric techniques (nuclear magnetic resonance and mass spectrometry), we propose a revised structure of the adducts obtained through the H2O2-peroxidase oxidation of the antitumor drug ellipticinium and aliphatic amino(acid) compounds. These derivatives display an oxazole ring structure between the O(9)- and N(10)- atoms.
D000470:Alkaloids; D000596:Amino Acids; D001894:Borohydrides / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004611:Ellipticines; D006861:Hydrogen Peroxide; D007527:Isoenzymes; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008970:Molecular Weight; D010084:Oxidation-Reduction; D009195:Peroxidase; D010544:Peroxidases; D013053:Spectrophotometry
D000470:Alkaloids; D000596:Amino Acids; D001894:Borohydrides; D004611:Ellipticines; D007527:Isoenzymes; C027767:elliptinium; C025364:sodium borohydride; D006861:Hydrogen Peroxide; D010544:Peroxidases; D009195:Peroxidase