Identification of the pleiotropic sacQ gene of Bacillus subtilis.
The sacQ gene of Bacillus subtilis, a pleiotropic gene affecting the expression of a number of secreted gene products, has been identified as a small 46-amino-acid polypeptide. The increased expression of this polypeptide in strains carrying the sacQ36 allele, or in strains carrying the sacQ gene on a high copy plasmid, appears to be responsible for the phenotype of higher levels of proteases seen in these strains. A deletion of the sacQ gene had no apparent phenotype, indicating that it is not an essential gene.
D000483:Alleles; D001412:Bacillus subtilis / Q000235:genetics*; D001426:Bacterial Proteins / Q000032:analysis; D001483:Base Sequence; D005798:Genes, Bacterial; D005809:Genes, Regulator; D009154:Mutation; D010447:Peptide Hydrolases / Q000096:biosynthesis; D010957:Plasmids; D012333:RNA, Messenger / Q000032:analysis; D014158:Transcription, Genetic; D014169:Transformation, Bacterial
D001426:Bacterial Proteins; D012333:RNA, Messenger; D010447:Peptide Hydrolases