[Inhibition of the reproduction of a herpes simplex I virus carrying mutations in the thymidine kinase and DNA polymerase genes].
Sensitivity of Herpes Simplex Virus type I (HSV-I) mutants carrying genetic defect in the DNA polymerase and thymidine kinase genes to the action of some drugs was studied. TK- mutant of HSV-I was resistant to Ara-T and ACG and sensitive to PAA, Ara-A as well as to ribavirin and ADEA. PAAr mutant of HSV-I was resistant to PAA, Ara-A, ACG and sensitive to Ara-T, ribavirin and ADEA. A double mutant of HSV-I-TK-, PAAr was resistant to all drugs, except for ribavirin and ADEA. To inhibit reproduction of HSV with genetic defect, it is important using drugs of independent mode of action on the function of defective viral gene.
D000963:Antimetabolites / Q000494:pharmacology*; D002872:Chromosome Deletion; D004259:DNA-Directed DNA Polymerase / Q000235:genetics*; D003864:Depression, Chemical; D005814:Genes, Viral / Q000187:drug effects*; D009154:Mutation; D018139:Simplexvirus / Q000187:drug effects* / Q000235:genetics; D013937:Thymidine Kinase / Q000235:genetics*; D014779:Virus Replication / Q000187:drug effects*
D000963:Antimetabolites; D013937:Thymidine Kinase; D004259:DNA-Directed DNA Polymerase
Ingibirovanie reproduktsii virusa prostogo gerpesa I, nesushchego mutatsiĭ v timidinkinaznom i DNK-polimeraznom genakh.