Gene amplification in cancer: a molecular cytogenetic approach.
Many human tumors have been shown to exhibit cytologic evidence of gene amplification. In several instances the amplified genes have proven to be cellular oncogenes. We present an approach for combining cytogenetic and molecular biological techniques to systematically investigate this phenomenon.
D001483:Base Sequence; D002478:Cells, Cultured; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D004273:DNA, Neoplasm / Q000235:genetics; D004587:Electrophoresis, Agar Gel; D005784:Gene Amplification; D006801:Humans; D007621:Karyotyping; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes
D004273:DNA, Neoplasm; D004247:DNA; D004262:DNA Restriction Enzymes