The effects of prenatal chlordiazepoxide administration on avoidance behavior and benzodiazepine receptor density in adult albino rats.
Adult male and female offspring of rats injected daily with 10 mg/kg chlordiazepoxide during their pregnancy exhibited a facilitated acquisition of a two-way active avoidance response. Benzodiazepine receptor assays carried out on cortex and cerebral samples taken from experimental and control female rats showed a significant decrease in the density of benzodiazepine receptors, without changes in receptor affinity.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D002707:Chlordiazepoxide / Q000494:pharmacology*; D005260:Female; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects*
D011963:Receptors, GABA-A; D002707:Chlordiazepoxide