The glutamate analogue quisqualic acid is neurotoxic in striatum and hippocampus of immature rat brain.
To assess the neurotoxic properties of the glutamate agonist quisqualic acid (QA) in immature brain, we injected this compound (100 nmol QA/1 microliter) directly into the striatum of 7-day-old rats. QA produced neuronal necrosis and glial infiltration in 14 pups and reduced the size of the striatum and hippocampus on the side of injection. Intracerebral injection of QA provides a new method for producing neuronal lesions in the developing brain.
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000473:pathology; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D010069:Oxadiazoles / Q000494:pharmacology*; D010100:Oxygen / Q000502:physiology; D016318:Quisqualic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
D010069:Oxadiazoles; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D016318:Quisqualic Acid; D010100:Oxygen