Metabolic changes during cardiac maturation.
Oxidation rates of palmitate, pyruvate and 2-oxoisocaproate and activities of cytochrome c oxidase and citrate synthase were assayed in heart homogenates of newborn and adult rats and of adult man. All activities doubled or increased more in rat heart at maturation. The rise was due to an increase of both mitochondrial activity and content. In human heart all activities and mitochondrial content were lower than in newborn rat heart.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D002950:Citrate (si)-Synthase / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D006321:Heart / Q000254:growth & development*; D006801:Humans; D007651:Keto Acids / Q000378:metabolism; D008929:Mitochondria, Heart / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010168:Palmitates / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D051381:Rats
D007651:Keto Acids; D010168:Palmitates; D011773:Pyruvates; C013082:alpha-ketoisocaproic acid; D003576:Electron Transport Complex IV; D002950:Citrate (si)-Synthase