Production of no-carrier added 67Cu.
Copper-67 has been produced at the BLIP by 68Zn(p, 2p) and 70Zn(p, alpha) reactions with 193 MeV protons and at the HFBR using the 67Zn(n, p) route. The effective cross-sections of natZn(p, 2pxn)61,64,67Cu reactions were measured at 200 MeV and compared with predicted values obtained from semi-empirical formulae given by Silberberg and Tsao. From these cross-sections, the fraction of 64Cu in the final 67Cu preparations was estimated and compared with the experimental values. A procedure has been developed consisting of electrodeposition and ion-exchange for isolation of no-carrier-added radiocopper from a Zn target. The method is adaptable for remote hot cell operation. The overall radiochemical yield of 67Cu and the separation factors from a Zn target and other radionuclides were evaluated. The saturation yield of 67Cu produced by the fast neutron 67Zn(n, p) reaction and the corresponding cross-section were remeasured. Experiments have been initiated to attach 67Cu to monoclonal antibodies for immunotherapy applications.
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D003300:Copper / Q000627:therapeutic use; D004595:Electroplating; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy; D011854:Radiochemistry / Q000379:methods*; D011868:Radioisotopes / Q000627:therapeutic use; D015032:Zinc
D000911:Antibodies, Monoclonal; D011868:Radioisotopes; D003300:Copper; D015032:Zinc