Derepression of sporulation and synthesis of mycobacillin and dipicolinic acid by guanosine 3':5'-cyclic monophosphate under conditions of glucose repression in Bacillus subtilis.
Dibutyryl cyclic GMP, but not dibutyryl cyclic AMP, derepresses sporulation and synthesis of mycobacillin and dipicolinic acid under conditions of glucose repression in Bacillus subtilis strain B34. Neither of these compounds appears to affect sporulation and synthesis of mycobacillin and dipicolinic acid in this strain under normal physiological conditions. Mutants insensitive to glucose repression were indifferent to the addition of either of the nucleotides both in the presence and in the absence of glucose. A role for dibutyryl cyclic GMP in annulling the repressing effect of glucose on sporulation and on synthesis of mycobacillin and dipicolinic acid is thus indicated.
D000935:Antifungal Agents / Q000096:biosynthesis*; D001412:Bacillus subtilis / Q000502:physiology*; D006152:Cyclic GMP / Q000378:metabolism*; D003995:Dibutyryl Cyclic GMP / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D009154:Mutation; D009158:Mycobacillin / Q000096:biosynthesis*; D010848:Picolinic Acids / Q000096:biosynthesis*; D013171:Spores, Bacterial
D000935:Antifungal Agents; D010848:Picolinic Acids; D009158:Mycobacillin; D003995:Dibutyryl Cyclic GMP; D006152:Cyclic GMP; D005947:Glucose; C004860:dipicolinic acid