Action of antidepressant neuroleptics, chlorprothixene and levomepromazine, on the central noradrenergic system: comparison with other antidepressants.
In contrast to imipramine, chlorprothixene (CPX) and levomepromazine (LMZ) given chronically did not affect clonidine-induced hypothermia and depression of noradrenaline synthesis rate, while similarly to imipramine and citalopram depressed the density of cortical 3H-clonidine binding sites and increased their affinity. Two week treatment with the antidepressants did not affect the parameters of 3H-dihydroalprenolol binding sites, while spiroperidol administration increased their density, without changing KD values. The data suggest that changes in alpha 2 adrenoceptor population parameters may be a general characteristics of antidepressant treatment, but not necessarily followed by changes in clonidine effects.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001341:Autonomic Nervous System / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D002749:Chlorprothixene / Q000494:pharmacology*; D003000:Clonidine / Q000494:pharmacology; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008728:Methotrimeprazine / Q000494:pharmacology*; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013134:Spiperone / Q000494:pharmacology; D013574:Synaptosomes / Q000378:metabolism
D000928:Antidepressive Agents; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D013134:Spiperone; D004295:Dihydroxyphenylalanine; D008728:Methotrimeprazine; D002749:Chlorprothixene; D003000:Clonidine; D009638:Norepinephrine