title: Topology of signal recognition particle receptor in endoplasmic reticulum membrane.
abstract: The signal recognition particle (SRP) receptor is an integral membrane protein of the endoplasmic reticulum which, in conjunction with SRP, ensures the correct targeting of nascent secretory proteins to this membrane system. From the complementary DNA sequence we have deduced the complete primary structure of the SRP receptor and established that its amino-terminal region is anchored in the membrane. The anchor fragment and the cytoplasmic fragment contribute jointly to a functionally important region which is highly charged and may function in nucleic acid binding.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004285:Dogs; D004721:Endoplasmic Reticulum / Q000648:ultrastructure*; D007425:Intracellular Membranes / Q000648:ultrastructure; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D008970:Molecular Weight; D010179:Pancreas / Q000648:ultrastructure; D010446:Peptide Fragments; D021382:Protein Sorting Signals / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear; D018000:Receptors, Peptide; D012995:Solubility; D013329:Structure-Activity Relationship
chemical_list: D008565:Membrane Proteins; D010446:Peptide Fragments; D021382:Protein Sorting Signals; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D018000:Receptors, Peptide; C036318:signal peptide receptor; D004247:DNA