The possible involvement of cytochrome P-450 monooxygenase in AVP-induced ACTH secretion.
AVP (10(-7) M) induced ACTH as well as PGE2 release from rat anterior pituitary quarters. Inhibitors of P-450 monooxygenase, metyrapone (10 mM) and piperonyl butoxide (1 mM and 10 mM) attenuated the ACTH and PGE2 response to AVP. 7,8-benzoflavon (10 mM) which inhibits 3-methylchloranthrene inducible form of P-450 isoenzymes showed no inhibition of AVP-induced ACTH secretion. The decrease in ACTH response to AVP was still observed following the inhibition of prostaglandin synthesis by indomethacin. These results suggest that cytochrome P-450 monoocygenase systems are involved in the process of AVP-induced ACTH secretion, 3-methylchloranthrene inducible form of P-450 isoenzymes do not seem to be involved in this process.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001571:Benzoflavones / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System; D015232:Dinoprostone; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008797:Metyrapone / Q000494:pharmacology; D010105:Oxygenases / Q000037:antagonists & inhibitors / Q000502:physiology*; D010882:Piperonyl Butoxide / Q000494:pharmacology; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism*; D011458:Prostaglandins E / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D001095:Arachidonic Acids; D001571:Benzoflavones; D011458:Prostaglandins E; D001127:Arginine Vasopressin; D016718:Arachidonic Acid; C011512:alpha-naphthoflavone; D000324:Adrenocorticotropic Hormone; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D015232:Dinoprostone; D010882:Piperonyl Butoxide; D007213:Indomethacin; D008797:Metyrapone