A sequence homology between the pX genes of HTLV-I/II and the murine IL-3 gene.
Searching the protein sequence database for amino acid sequences homologous to the x-lor sequence in the pX region of human T-cell leukemia virus types I and II (HTLV-I/II), we found that there is a region of 38 amino acids where the murine interleukin 3 (IL-3) sequence has a 40% homology with the x-lor sequence. A statistical analysis shows that this homology is highly significant with a probability of 1.57 X 10(-10). The biological implication of this homology is discussed.
D000595:Amino Acid Sequence; D000818:Animals; D017977:Deltaretrovirus / Q000235:genetics*; D005814:Genes, Viral; D007377:Interleukin-3 / Q000235:genetics*; D051379:Mice; D011487:Protein Conformation; D012191:Retroviridae Proteins / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D007377:Interleukin-3; D012191:Retroviridae Proteins