Comparison between delta-9-tetrahydrocannabinol and cannabis extract on resorption rate in mice.
Delta-9-tetrahydrocannabinol, the principal psychoactive ingredient in cannabis extract, and cannabis extract containing an equivalent amount of delta-9-tetrahydrocannabinol were administered to different groups of pregnant mice on gestation days 7-15 inclusive. There was a significant dose-related increase in resorptions but no significant difference between compounds in resorption rate, nor was there any significant interaction between drug and dosage. The results suggest that compounds in cannabis extract do not modify the actions of delta-9-tetrahydrocannabinol on resorption rate.
D000818:Animals; D002188:Cannabis; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D013759:Dronabinol / Q000633:toxicity*; D004435:Eating / Q000187:drug effects; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D005327:Fetal Resorption / Q000139:chemically induced*; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000633:toxicity*; D011247:Pregnancy
D010936:Plant Extracts; D013759:Dronabinol