Serum angiotensin-converting enzyme in leprosy.
Serum angiotensin-converting enzyme activity was measured in 91 adult healthy and lepromatous armadillos before inoculation with M. leprae and at necropsises. Mean ACE values were significantly elevated in armadillos with leprosy and the degree of elevation was roughly proportional to the extent of infection. There was also significant difference in the serum ACE levels between Florida and Louisiana armadillos. The dapsone treatment resulted in bringing these levels to normal. Serial assays of serum, ACE provided information on the response of armadillos to dapsone therapy.
D000818:Animals; D001135:Armadillos / Q000097:blood; D003622:Dapsone / Q000627:therapeutic use; D005431:Florida; D007918:Leprosy / Q000188:drug therapy / Q000201:enzymology*; D008145:Louisiana; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D014687:Venezuela
D003622:Dapsone; D007703:Peptidyl-Dipeptidase A