Human cytomegalovirus completely helps adeno-associated virus replication.
Coinfection of adeno-associated virus (AAV) with human cytomegalovirus (HCMV) strain Towne in human embryonic fibroblasts resulted in accumulation of AAV capsid antigen and production of infectious AAV with a lag of 24 hr compared to AAV replication in AAV-adenovirus coinfections. In contrast to previous observation, these findings demonstrated that HCMV is a competent helper virus for the complete replication of AAV. In addition, HCMV and AAV were synergistic in their cytopathic effects on cells, suggesting the possibility that AAV may play a role in the pathogenicity of HCMV infections.
D000956:Antigens, Viral / Q000032:analysis*; D002213:Capsid / Q000276:immunology; D002472:Cell Transformation, Viral; D003587:Cytomegalovirus / Q000235:genetics*; D004261:DNA Replication; D000229:Dependovirus / Q000235:genetics*; D004622:Embryo, Mammalian; D005347:Fibroblasts; D006801:Humans; D007700:Kinetics; D010948:Viral Plaque Assay; D014779:Virus Replication
D000956:Antigens, Viral