Comparison of mammalian VIP bioactivities in dispersed acini from guinea pig pancreas.
Mammalian VIP is identical in pig, cow, human, rat, dog and goat but differs in the guinea pig (GP) in positions 5, 9, 19, and 26. We now demonstrate that GP, goat, rat and synthetic mammalian VIP are indistinguishable in their inhibition of binding of 125I-labelled synthetic VIP to dispersed acini from GP pancreas and that GP, pig, dog, goat and synthetic VIP are also similar in their efficacy and potency in stimulating amylase release from these acini. Thus in spite of the differences in amino acid sequence, GP VIP appears to have full biologic potency in its action on dispersed acini from GP pancreas.
D000818:Animals; D001667:Binding, Competitive; D002417:Cattle; D004285:Dogs; D006041:Goats; D006168:Guinea Pigs; D006801:Humans; D007700:Kinetics; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D018005:Receptors, Vasoactive Intestinal Peptide; D013045:Species Specificity; D013552:Swine; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism* / Q000494:pharmacology
D011956:Receptors, Cell Surface; D018005:Receptors, Vasoactive Intestinal Peptide; D014660:Vasoactive Intestinal Peptide