title: Radiopharmaceuticals for spleen and bone marrow studies.
abstract: The spleen and bone marrow have important hematologic functions. Evaluation of bone marrow alone may be incomplete, unless the function of the spleen is studied also. In addition to hematologic functions, each organ has unique characteristics that may need to be evaluated in assessing its activity. The evaluation of the distribution of reticuloendothelial cells, through the phagocytosis of radioactive particles, provides the basis for most of the morphological and functional studies of these organs. During the past three decades, a variety of radioactive agents have been prepared and examined. Among them, colloids of 99mTc, heat-damaged 99mTc labeled RBCs, and the radionuclides of iron and indium, make possible the functional and morphological examination of the spleen and bone marrow by external scintigraphy.
mesh_terms: D000818:Animals; D000965:Antimony; D001853:Bone Marrow / Q000000981:diagnostic imaging*; D002860:Chromium Radioisotopes; D003102:Colloids; D004912:Erythrocytes; D005710:Gallium Radioisotopes; D006048:Gold Colloid, Radioactive; D006801:Humans; D007204:Indium; D007457:Iodine Radioisotopes; D007504:Iron Radioisotopes; D015609:Organotechnetium Compounds; D010833:Phytic Acid; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging*; D013667:Technetium; D017556:Technetium Compounds; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D002860:Chromium Radioisotopes; D003102:Colloids; D005710:Gallium Radioisotopes; D006048:Gold Colloid, Radioactive; D007457:Iodine Radioisotopes; D007504:Iron Radioisotopes; D015609:Organotechnetium Compounds; D011868:Radioisotopes; D017556:Technetium Compounds; C019096:technetium Tc 99m antimony sulfide; C026177:technetium phytate; D007204:Indium; D013671:Technetium Tc 99m Sulfur Colloid; D013667:Technetium; D010833:Phytic Acid; D000965:Antimony