title: Gene structure of calcium-dependent protease retains the ancestral organization of the calcium-binding protein gene.
abstract: The gene structure of calcium-dependent protease (Ca2+-protease) was determined. It comprises at least 21 exons, and these were assigned to the 4 functional domains of the protease. The protease domain does not show clear correlation between exons and functional units, but the calmodulin-like calcium-binding domain shows strong correlation. Each of the 4 consecutive calcium-binding regions in the C-terminal part of Ca2+-protease is encoded by one exon. This gene structure supports the idea that the 4 calcium-binding regions of calcium-binding proteins such as calmodulin arose by 2 steps of gene duplication.
mesh_terms: D000818:Animals; D001483:Base Sequence; D002154:Calpain / Q000235:genetics*; D002645:Chickens; D003001:Cloning, Molecular; D004261:DNA Replication; D004270:DNA, Circular / Q000378:metabolism; D005796:Genes; D009693:Nucleic Acid Hybridization
chemical_list: D004270:DNA, Circular; D002154:Calpain