Effect of intravenously injected collagenase on the concentration of circulating platelets in rats.
An enzymatically induced irritation of the vessel wall by intravenous injection of collagenase (1.5 U per kg body weight) into rats resulted in a transient decrease of the platelet concentration in the flowing blood. This may be caused by an occurrence of inter-endothelial gaps distributed throughout the total area of the circulatory system, as could be observed by electron-microscopic studies. Subendothelial structures, at the sites of those gaps, induce a formation of multilocal microthrombi of platelets. At some gaps within the endothelial layer a deposit of fibrin could also be observed hinting at a participation of the blood coagulation system in the sealing processes.
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000648:ultrastructure; D004727:Endothelium / Q000648:ultrastructure; D005337:Fibrin / Q000378:metabolism; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D007700:Kinetics; D008643:Mesentery / Q000098:blood supply; D003012:Microbial Collagenase / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D005337:Fibrin; D003012:Microbial Collagenase