Unaltered stimulation of pituitary adrenocorticotrophin secretion by corticotrophin-releasing factor following sodium valproate administration in a patient with Nelson's syndrome.
A 53-year-old woman with Nelson's syndrome was treated with 600 mg sodium valproate daily. Her plasma ACTH was effectively decreased, whilst the response of plasma ACTH to corticotrophin-releasing factor (CRF) was unaltered. The result of the CRF test suggested that sodium valproate, at least in the present patient, acted at the hypothalamic level.
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009347:Nelson Syndrome / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000503:physiopathology*; D013268:Stimulation, Chemical; D014635:Valproic Acid / Q000627:therapeutic use*
D014635:Valproic Acid; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone