Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro.
Omeprazole has been previously shown to block gastric acid secretion by specific inhibition of gastric parietal cell membrane H+-K+-ATPase. It is now demonstrated that similar concentrations of omeprazole will inhibit PGE2- and PTH-stimulated 45Ca++ release from prelabelled neonatal mouse calvariae without affecting the viability of cultured calvaria explants.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D001862:Bone Resorption / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism; D017506:H(+)-K(+)-Exchanging ATPase; D066298:In Vitro Techniques; D051379:Mice; D009853:Omeprazole; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism
D001562:Benzimidazoles; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase; D009853:Omeprazole; D002118:Calcium