Inhibition of protein kinase activity by apomorphine.
The effect of apomorphine (1-20 microM) on protein kinase activity was studied in extracts from rat peritoneal mast cells and brain tissue. Apomorphine inhibited the cyclic AMP-dependent and the calcium-plus phosphatidylserine-dependent protein kinase activity with an IC50 between 1 and 6 microM, depending on the tissue and on the protein kinase involved. This effect might explain previous results on the apomorphine-induced inhibition of histamine release in rat peritoneal mast cells.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology; D000242:Cyclic AMP / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000201:enzymology; D047428:Protein Kinase Inhibitors; D051381:Rats; D013050:Spectrometry, Fluorescence; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D047428:Protein Kinase Inhibitors; D000242:Cyclic AMP; D001058:Apomorphine; D013755:Tetradecanoylphorbol Acetate