Clonal rearrangement and expression of the T cell receptor beta gene and involvement of the breakpoint cluster region in blast crisis of CGL.
A case of lymphoid blast crisis of Ph1-positive CGL is described in which the blast cells had an immature T cell phenotype, clonal rearrangement and expression of the T cell receptor beta gene, and a rearrangement of the breakpoint cluster region (bcr) on chromosome 22. This case therefore provides definite evidence for transformation involving a common myeloid-T lineage progenitor, penetrance of the Ph1 molecular alteration into the T cell lineage, and clonal selection in blast crisis at the level of a committed T lineage precursor.
D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes; D005796:Genes; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D046911:Macromolecular Substances; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D010677:Philadelphia Chromosome; D011948:Receptors, Antigen, T-Cell / Q000235:genetics* / Q000276:immunology; D011995:Recombination, Genetic; D014178:Translocation, Genetic
D046911:Macromolecular Substances; D011948:Receptors, Antigen, T-Cell; D004262:DNA Restriction Enzymes