Receptors for epidermal growth factor in human mammary carcinomas and their metastases.
The tumor cell content of the receptor for epidermal growth factor (EGF-R) and estrogen receptor (ER) was analyzed in 36 primary breast carcinomas and their metastatic deposits. Twenty-five percent of the primary tumors and 48 percent of the metastases exhibited measurable levels of the receptor. The frequency of EGF-R positivity was the same for cutaneous and lymph node recurrences. No discrepancy was observed with respect to ER content between primary tumors and their metastases.
D001943:Breast Neoplasms / Q000032:analysis*; D066246:ErbB Receptors; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D011956:Receptors, Cell Surface / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis
D011956:Receptors, Cell Surface; D011960:Receptors, Estrogen; D066246:ErbB Receptors