Sulpiride and the potentiation of progestogen only contraception.
A progestogen (norethisterone) and a dopamine antagonist (sulpiride) were given alone and in combination to volunteers to examine their effects on excretion of ovarian steroids. Compared with non-treatment cycles (n = 15), contraception with a progestogen alone (n = 10) was associated with increased excretion of oestrone and partial suppression of excretion of pregnanediol, suggesting partial luteinization of unruptured follicles. By contrast, the combination of norethisterone and sulpiride (n = 9) suppressed both ovarian steroids to basal values, the suppression being even greater than with sulpiride alone (n = 5). These results suggest that a combination of a progestogen with a dopamine antagonist might have a role in contraception.
D000328:Adult; D003276:Contraceptives, Oral; D004357:Drug Synergism; D004966:Estrogens, Conjugated (USP) / Q000652:urine; D004970:Estrone / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D008597:Menstrual Cycle; D009640:Norethindrone / Q000494:pharmacology*; D010053:Ovary / Q000378:metabolism; D011276:Pregnanediol / Q000031:analogs & derivatives / Q000652:urine; D011388:Prolactin / Q000097:blood; D013469:Sulpiride / Q000494:pharmacology*
D003276:Contraceptives, Oral; D004966:Estrogens, Conjugated (USP); C022270:pregnanediol-3 alpha-glucuronide; C015856:estrone-3-glucuronide; D004970:Estrone; D013469:Sulpiride; D011388:Prolactin; D011276:Pregnanediol; D009640:Norethindrone