title: In vitro buffering capacity of Alka Seltzer Effervescent. A comparison with magnesium trisilicate mixture B.P. and sodium citrate 0.3 M.
abstract: The variety of antacids used as a prophylaxis for acid aspiration syndrome reflects dissatisfaction with each agent. Alka Seltzer Effervescent is a proprietary product without aspirin. We have shown that it can easily be dissolved in a small volume, readily mixes with hydrous fluids, and has a satisfactory neutralising capacity. Its non-particulate nature, storage in individual packages and palatability, indicated by commercial acceptance overseas, show that further trials in vivo as a method of raising gastric pH may be useful.
mesh_terms: D000388:Air; D000863:Antacids; D001639:Bicarbonates; D002021:Buffers; D055598:Chemical Phenomena; D002621:Chemistry; D002951:Citrates; D019343:Citric Acid; D004338:Drug Combinations; D006851:Hydrochloric Acid; D006863:Hydrogen-Ion Concentration; D008274:Magnesium; D017633:Magnesium Silicates; D012824:Silicic Acid; D012822:Silicon Dioxide; D017693:Sodium Bicarbonate
chemical_list: D000863:Antacids; D001639:Bicarbonates; D002021:Buffers; D002951:Citrates; D004338:Drug Combinations; D017633:Magnesium Silicates; C012845:sodium citrate, sodium bicarbonate drug combination; D012824:Silicic Acid; D019343:Citric Acid; D012822:Silicon Dioxide; D017693:Sodium Bicarbonate; C001671:magnesium trisilicate; D008274:Magnesium; D006851:Hydrochloric Acid