Human proto-oncogene c-mos maps to 8q11.
The c-mos proto-oncogene is the cellular counterpart of the viral oncogene v-mos isolated from Moloney murine sarcoma virus. The c-mos gene locus has previously been assigned to human chromosome 8. By both in situ hybridization and molecular hydridization to sorted chromosome DNA (using a c-mos probe) we have localized the c-mos gene to band 8q11. This regional localization is at variance with the one previously reported at 8q22 and may explain why no rearrangement of c-mos has been found in acute leukaemia with the chromosomal translocation t(8;21)(q22;q22).
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D002871:Chromosome Banding; D002906:Chromosomes, Human, 6-12 and X; D003001:Cloning, Molecular; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid; D008214:Lymphocytes / Q000166:cytology; D008677:Metaphase; D051379:Mice; D008980:Moloney murine sarcoma virus / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010957:Plasmids; D014176:Protein Biosynthesis; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D009053:Sarcoma Viruses, Murine / Q000235:genetics*; D014178:Translocation, Genetic