Mycobacterium marinum infection in gnotobiotic nu/nu mice pretreated with cyclophosphamide and silica.
Germfree nude mice (NMRJ-nu/nu) and germfree nu/+ mice were infected with Mycobacterium marinum in the footpad test. After pretreatment with 400 mg/kg cyclophosphamide, significantly higher amounts of M. marinum were reached in the footpad and in the liver. On the other hand, the yield of M. marinum could not be elevated by in vivo inhibition of macrophages with silica.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D003520:Cyclophosphamide / Q000494:pharmacology*; D005856:Germ-Free Life; D008099:Liver / Q000382:microbiology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008819:Mice, Nude; D009164:Mycobacterium Infections / Q000276:immunology*; D009165:Mycobacterium Infections, Nontuberculous / Q000276:immunology* / Q000382:microbiology; D009170:Nontuberculous Mycobacteria / Q000254:growth & development / Q000276:immunology; D012822:Silicon Dioxide / Q000494:pharmacology*
D012822:Silicon Dioxide; D003520:Cyclophosphamide