[Mechanism of the suppression of the spinal pain syndrome by serotonin derivatives].
The ability of serotonin derivatives to stimulate cAMP accumulation in isolated nerve terminals and lumbar enlargement of the spinal cord of normal rats was compared. The effect of the compounds on the intensity of spinal pain syndrome was also assessed. It has been established that substitutes injected into NH2-group of serotonin in 5-OH position attenuate the ability to stimulate cAMP accumulation in synaptosomes, with the effect more pronounced with substitutes of larger volume. A certain correlation between the ability of serotonin derivatives to stimulate adenylate cyclase in vivo and in vitro, on the one hand, and their analgetic effect, on the other hand, is suggested.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D003864:Depression, Chemical; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D010400:Penicillin G / Q000633:toxicity; D051381:Rats; D012701:Serotonin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013118:Spinal Cord Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism; D013577:Syndrome
D012701:Serotonin; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D010400:Penicillin G
Mekhanizm podavleniia spinal'nogo bolevogo sindroma proizvodnymi serotonina.