Determination of mezlocillin and its penicilloate and penilloate by high-performance liquid chromatography and stability of mezlocillin at different temperatures.
A method is described for the determination of mezlocillin and its metabolites penicilloic acid and penilloic acid in biological fluids by high-performance liquid chromatography. The stability of mezlocillin in serum and buffer was studied at different temperatures (4, -20, -70, and -196 degrees C) over a period of 6 months. Mezlocillin remained stable at -70 and -196 degrees C, whereas degradation was observed at -20 and 4 degrees C in serum and buffer.
D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D008802:Mezlocillin / Q000032:analysis*; D010397:Penicillanic Acid / Q000032:analysis* / Q000031:analogs & derivatives; D010400:Penicillin G / Q000031:analogs & derivatives* / Q000032:analysis; D013696:Temperature; D013997:Time Factors
C008782:penicilloic acid; D010397:Penicillanic Acid; C017609:penilloic acid; D008802:Mezlocillin; D010400:Penicillin G