Enhanced replication of murine cytomegalovirus in murine leukemic lymphocytes.
Replication in vitro of murine cytomegalovirus was found to be enhanced in lymphoid cells from leukemic (AKR/J) mice as compared with similar cells from nonleukemic animals. Prolonged productive murine cytomegalovirus infection in lymphoid organs in vivo was demonstrable only in leukemic AKR/J mice. Latent nonproductive murine cytomegalovirus infection established in young nonleukemic AKR/J mice was invariably reactivated and expressed in salivary glands and lymphoid organs after these animals became leukemic.
D000818:Animals; D000831:Animals, Newborn / Q000382:microbiology; D003587:Cytomegalovirus / Q000235:genetics*; D007942:Leukemia, Experimental / Q000382:microbiology*; D008214:Lymphocytes / Q000382:microbiology*; D051379:Mice; D012469:Salivary Glands / Q000382:microbiology; D013154:Spleen / Q000166:cytology / Q000382:microbiology; D013950:Thymus Gland / Q000166:cytology / Q000382:microbiology; D014779:Virus Replication