title: ORF 13904, a new long-acting vaginal contraceptive.
abstract: A sulfonated polystyrene polymer, ORF 13904, was discovered in our laboratory to be a highly effective vaginal contraceptive in the rabbit model and to possess a unique mode of action. It was found to be non-spermicidal even at high concentrations, yet it greatly impeded sperm penetration of cervical mucus in vitro. When a gel formulation containing 5% ORF 13904 was administered to rabbits intravaginally, the mean number of fetal implants was reduced dramatically even when coitus was delayed for up to 8 hours or when multiple matings at different time intervals were permitted. The non-spermicidal qualities and extended duration of action of this compound represent major breakthroughs in the development of vaginal contraceptives.
mesh_terms: D000818:Animals; D002417:Cattle; D002582:Cervix Mucus; D003271:Contraceptive Agents, Female / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D017137:Nonoxynol; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000494:pharmacology; D011137:Polystyrenes / Q000008:administration & dosage* / Q000494:pharmacology; D011247:Pregnancy; D011817:Rabbits; D013081:Sperm Motility / Q000187:drug effects; D013083:Sperm Transport / Q000187:drug effects; D013997:Time Factors; D014621:Vagina
chemical_list: D003271:Contraceptive Agents, Female; D011137:Polystyrenes; C047156:ORF 13904; D017137:Nonoxynol; D011092:Polyethylene Glycols