Biomolecular photoalterations mediated by phenothiazine derivatives.
This survey focuses on recent developments in the field of the ultraviolet photochemistry and photobiology of phenothiazine derivatives. One of the major alterations introduced by this kind of photosensitized reaction is a covalent addition of the photosensitizer or one of its photoproducts onto the macromolecular target. This reaction has been observed with soluble and membrane proteins, lipids and DNA. In the latter case, the addition occurs at the level of guanine residues and leads to inhibition of DNA replication.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002746:Chlorpromazine / Q000378:metabolism; D004247:DNA / Q000378:metabolism / Q000528:radiation effects; D005609:Free Radicals; D008055:Lipids / Q000528:radiation effects; D008565:Membrane Proteins / Q000528:radiation effects; D010100:Oxygen; D010640:Phenothiazines / Q000378:metabolism; D010777:Photochemistry; D010782:Photolysis; D011395:Promazine / Q000378:metabolism; D011506:Proteins / Q000528:radiation effects; D026082:Singlet Oxygen; D012996:Solutions; D013481:Superoxides; D014466:Ultraviolet Rays
D001798:Blood Proteins; D005609:Free Radicals; D008055:Lipids; D008565:Membrane Proteins; D010640:Phenothiazines; D011506:Proteins; D012996:Solutions; D013481:Superoxides; D026082:Singlet Oxygen; D004247:DNA; D011395:Promazine; D010100:Oxygen; D002746:Chlorpromazine