title: Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2.
abstract: A complementary DNA (cDNA) probe for the predominant (pI 7) form of human monocyte-derived interleukin-1 (IL1) and a collection of 30 human-mouse somatic cell hybrids were used to assign the IL1 gene to human chromosome 2 by Southern blot analysis of hybrid cell DNA digested with the restriction endonuclease BglII. In situ hybridization to human metaphase chromosomes localized the IL1 gene to the long arm of chromosome 2 at position 2q13-2q21 between two fragile sites.
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3; D003001:Cloning, Molecular; D004247:DNA / Q000378:metabolism; D004262:DNA Restriction Enzymes; D005796:Genes; D006801:Humans; D006822:Hybrid Cells / Q000166:cytology; D007375:Interleukin-1 / Q000235:genetics*; D051379:Mice; D009693:Nucleic Acid Hybridization
chemical_list: D007375:Interleukin-1; D004247:DNA; D004262:DNA Restriction Enzymes