[Manifestation of the neurotoxic effect of the organochlorine pesticide hexachlorobutadiene in the postnatal period of ontogeny in the rat].
Daily peroral administration of chlororganic pesticide hexachlorobutadiene in doses 8.1 mg/kg (1/20 LD50) to pregnant rats results in certain ultrastructural changes of neurocytes and myelin fibers of the spinal cord both in the animals and their offspring (newborns and 1-2-month-old rats). By means of electron paramagnetic resonance (EPR) method, changes in intensity of the EPR-signals of free radicals in the spinal cord, ceruloplasmin of blood serum have been revealed in the experimental pregnant animals, as well as in 1-month-old rats (in the latter--in the brain, too). Gas-liquid chromatography reveals the preparation contents in the adrenals, heart, brain and spinal cord, in the uterus of the pregnant animals, as well as in corresponding organs of their offspring. Certain retardation in growth and decrease in body mass are noted in the offspring.
D000818:Animals; D002070:Butadienes / Q000633:toxicity*; D002570:Ceruloplasmin / Q000032:analysis; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D005609:Free Radicals; D005659:Fungicides, Industrial / Q000633:toxicity*; D008431:Maternal-Fetal Exchange; D009186:Myelin Sheath / Q000648:ultrastructure; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D051381:Rats; D013116:Spinal Cord / Q000648:ultrastructure
D002070:Butadienes; D005609:Free Radicals; D005659:Fungicides, Industrial; C001335:hexachlorobutadiene; D002570:Ceruloplasmin
Proiavlenie neĭrotoksicheskogo éffekta khlororganicheskogo pestitsida geksakhlorobutadiena v postnatal'nom periode ontogeneza u krys.