[Status and prospects in the use of biocatalysis in the synthesis of beta-lactam antibiotics].
The present world status of using biocatalysts for production of beta-lactam antibiotics and their semiproducts is analyzed and the biocatalytic and chemical methods for production of antibiotics are compared. The requirements to the quality of biocatalysts used in production of drugs are formulated and the criteria of the efficiency of biocatalytic production processes are presented. Interrelation between the requirements to the biocatalyst quality and the efficiency of the biocatalytic production processes is examined. The general principles of development of efficient enzymatic processes including biocatalytic processes in production of beta-lactam antibiotics as closed-loop and practically wasteless systems are discussed. The main advantages of the developed production processes are illustrated by an example of large-scale processes use in manufacturing of the basic products for synthesis of beta-lactam compounds.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D002384:Catalysis; D055598:Chemical Phenomena; D002621:Chemistry; D004800:Enzymes, Immobilized; D010397:Penicillanic Acid / Q000138:chemical synthesis / Q000031:analogs & derivatives; D010399:Penicillin Amidase
D000900:Anti-Bacterial Agents; D004800:Enzymes, Immobilized; D010397:Penicillanic Acid; D010399:Penicillin Amidase; C004408:aminopenicillanic acid
Sostoianie i perspektivy ispol'zovaniia biokataliza dlia polucheniia betalaktamnykh antibiotikov.