All three polyoma early genes are involved in transformation of rat embryo fibroblast cells.
The tumor progression concept was first defined by Foulds at the end of the nineteen fifties. His work about the evolution of mammary tumors led to the conclusion that a tumor is initiated as soon as a cell interacts with an oncogenic agent and that the tumor progresses by acquiring in a permanent and irreversible way, new properties which are characteristic of neoplasms. Molecular biology made possible the identification in transformed cells of molecular events such as chromosomal rearrangements, mutations, the loss of certain genes or integration of viral genes. Experimental models have been introduced in order to try to identify in vitro the successive steps leading to transformation and the corresponding cellular phenotypes. One of these models is the cellular transformation phenomenon induced by polyoma virus. In this model, it now seems clear that several steps and several genes are involved in the cellular transformation phenomenon.
D000818:Animals; D000957:Antigens, Viral, Tumor / Q000235:genetics; D002472:Cell Transformation, Viral; D005347:Fibroblasts; D005814:Genes, Viral; D011120:Polyomavirus / Q000235:genetics*; D051381:Rats; D014764:Viral Proteins / Q000235:genetics
D000957:Antigens, Viral, Tumor; D014764:Viral Proteins