Angiotensin converting enzyme activity, prostaglandin F2 alpha- and immunoglobulin E level in childhood asthma bronchiale.
Angiotensin converting enzyme activity, prostaglandin F2 alpha and immunoglobulin E level have been studied in 35 asthmatic and 20 control children. The patients were divided in three groups: sever, mid-severe and moderate according to the severity of asthma. Angiotensin converting enzyme activity was the lowest in the severe and mid-severe groups. Prostaglandin F2 alpha was high in all three asthmatic groups. Immunoglobulin E level was highest in the severe group, but in the mid-severe and moderate groups it was high too. There was a significant negative correlation between prostaglandin F2 alpha level and angiotensin converting enzyme activity. Neither we found a correlation between the levels of prostaglandin F2 alpha and immunoglobulin E, nor between the immunoglobulin E level and angiotensin converting enzyme activity. These data suggest that angiotensin converting enzyme and prostaglandin F2 alpha may play a primary or secondary role in control of vascular tone of asthma bronchiale.
D000293:Adolescent; D001249:Asthma / Q000378:metabolism*; D002648:Child; D015237:Dinoprost; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D011460:Prostaglandins F / Q000032:analysis*
D011460:Prostaglandins F; D007073:Immunoglobulin E; D015237:Dinoprost; D007703:Peptidyl-Dipeptidase A