A region flanking H-2K is duplicated to a distant site in most mouse t haplotypes.
Mouse t haplotypes contain at least one inversion, which encompasses the major histocompatibility complex, relative to their wild-type counterparts. A DNA probe for a single copy sequence which flanks the H-2K region in inbred strains was found to have undergone further rearrangements in the t haplotypes. In most t haplotypes, this sequence is duplicated at a distant site, and the two regions show 1% recombination. The length of homology shared by the two sites is likely to be at least 10-15 kb. Three different alleles, as defined by restriction fragment length polymorphisms, were found for each of the two sites among different t haplotypes. These may reveal evolutionary relationships among these chromosomes.
D000483:Alleles; D000818:Animals; D007446:Chromosome Inversion; D004262:DNA Restriction Enzymes; D006183:H-2 Antigens / Q000235:genetics*; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics* / Q000276:immunology; D008817:Mice, Mutant Strains / Q000235:genetics; D010802:Phylogeny; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid
D006183:H-2 Antigens; C032876:H-2Kb protein, mouse; D004262:DNA Restriction Enzymes