title: Circadian changes of gluconeogenic enzymes in irradiated rats.
abstract: The authors studied the effect of whole body irradiation at different times of day on the circadian rhythms of gluconeogenic enzymes. They found that: 1. liver and kidney enzyme activities were highest in the light part of the day and lowest in the middle of the dark part; 2. 12-h circadian rhythm of glucose-6-phosphatase and fructose-1, 6-bisphosphatase activity in the liver and the renal cortex followed a similar course; 3. a lethal whole body dose of 14.4 Gy X-rays did not affect the circadian oscillation curves of the given enzymes, with the exception of fructose-1, 6-bisphosphatase in the liver of irradiated rats, where the rhythm was lost.
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000528:radiation effects*; D006597:Fructose-Bisphosphatase / Q000378:metabolism; D005943:Gluconeogenesis / Q000528:radiation effects*; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006597:Fructose-Bisphosphatase; D005952:Glucose-6-Phosphatase