[Inhibitory action of dopamine on excitatory transmission in the isolated spinal cord of the rat].
The effect of dopamine on the ventral root potential evoked by single supramaximal dorsal root stimulation was studied in the experiment in the isolated superfused spinal cord of 10-16 days old rats. It was discovered that application of dopamine caused the reversible dose-dependent inhibition of the mono- and polysynaptic ventral root reflex responses. The minimal effective concentration was 1 X 10(-8) mol/l. Dopamine applied in concentrations of 1 X 10(-4) mol/l and 1 X 10(-3) mol/l decreased the amplitude of the monosynaptic ventral root potential by 20% and 87% as against the control, respectively. Under the same conditions the amplitude of the polysynaptic ventral root potential decreased by 18% and 87% as against the control, respectively. The obtained results demonstrate that the dopaminergic brainstem-spinal pathways take part in the control of the transmission in the segmentary reflex arc.
D000818:Animals; D003864:Depression, Chemical; D004298:Dopamine / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D051381:Rats; D012018:Reflex / Q000187:drug effects*; D012023:Reflex, Monosynaptic / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects*; D013126:Spinal Nerve Roots / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*
D004298:Dopamine
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