title: The generation and regulation of human T lymphocytes by Imuthiol. Evidence from an in vitro differentiation induction system.
abstract: In vitro long term induction of human peripheral blood lymphocytes by sodium diethyldithiocarbamate, DTC (Imuthiol) enhanced the expression of OKT and HLA-DR phenotypic determinants. A population of T-B-DR+ cells was recruited from the null cell population. The increase in OKT+ cells, but not the enhanced HLA-DR expression appeared to be macrophage dependent. The surface markers of NK cells, monocytes or the pokeweed mitogen-induced IgM production were not modified. Collectively, the findings indicate that Imuthiol is not a B cell inducer, but is specifically active on the T-cell population in the way it induces the maturation of null cells into OKT+ DR+ lymphocytes.
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects*; D004050:Ditiocarb / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents; D007694:Killer Cells, Natural / Q000276:immunology; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D009000:Monocytes / Q000276:immunology; D010641:Phenotype; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D013859:Thiocarbamates / Q000494:pharmacology*
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007202:Indicators and Reagents; D013859:Thiocarbamates; D004050:Ditiocarb