title: [Effect of khingamin on the development of SV40 virus-induced and transplantable tumors in hamsters].
abstract: Chloroquine was administered to 2-month hamsters inoculated at birth with an oncogenic virus SV-40 which was injected daily in a dose of 30 mg/kg for a month. Chloroquine-treated animals showed a statistically significant (6 weeks) shorter latent period of tumour development. The drug exerted no effect neither on the rate and incidence of transplantable E-1 test tumours or on the phenomenon of resistance in experiments on 4-6-month hamsters under its multiple administration in doses close to maximum tolerated ones (40 mg/kg).
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002738:Chloroquine / Q000627:therapeutic use*; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D013539:Simian virus 40; D013997:Time Factors; D014412:Tumor Virus Infections / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D002738:Chloroquine
vernacular_title: Vliianie khingamina na razvitie indutsirovannykh virusom SV-40 i perevivaemykh opukholeĭ khomiakov.