Benzodiazepine receptors modulate circulating plasma vasopressin concentration.
Chlordiazepoxide pretreatment decreased basal levels of plasma arginine-vasopressin (AVP) and attenuated picrotoxin-induced increases in plasma AVP and blood pressure compared to saline-pretreated spinal animals. Prior administration of RO 15-1788 blocked the effects of chlordiazepoxide on basal plasma AVP as well as picrotoxin-evoked changes in plasma AVP and blood pressure. Thus, interactions at the benzodiazepine receptor may influence basal and evoked changes in plasma AVP concentration.
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood*; D001570:Benzodiazepinones / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002707:Chlordiazepoxide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005442:Flumazenil; D008297:Male; D010852:Picrotoxin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*
D001127:Arginine Vasopressin; D001570:Benzodiazepinones; D002707:Chlordiazepoxide; D005442:Flumazenil; D010852:Picrotoxin; D011963:Receptors, GABA-A