Characterization of the opioid receptor binding and animal pharmacology of meptazinol.
Meptazinol is a unique opioid analgesic. Binding studies suggest a relative selectivity for mu 1 sites, as opposed to the other opioid receptor binding sites. This binding selectivity is consistent with meptazinol's supraspinal site of action and its sensitivity to the mu 1-selective opiate antagonist naloxonazine. Furthermore, at equianalgesic doses, morphine depressed respiration to a greater degree than meptazinol.
D000698:Analgesia; D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D004285:Dogs; D008621:Meptazinol / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D009294:Narcotics / Q000378:metabolism; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects* / Q000378:metabolism
D001381:Azepines; D009294:Narcotics; D011957:Receptors, Opioid; D008621:Meptazinol; D009270:Naloxone