Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study.
Thirty-two patients were entered into a double blind trial of antiemetic support in patients being treated with cisplatin. Patients were allocated to receive either oral nabilone (1 mg 8 hourly) or intravenous metoclopramide (1 mg kg-1 3 hourly) in random order over 4 courses. There was no difference between the two treatments in the overall incidence or severity of vomiting, although a subgroup of patients enjoyed a substantial reduction in episodes of vomiting whilst receiving metoclopramide. Side-effects were predictable from the pharmacology of the drugs.
D000932:Antiemetics / Q000009:adverse effects; D002945:Cisplatin / Q000009:adverse effects*; D004311:Double-Blind Method; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008787:Metoclopramide / Q000627:therapeutic use*; D009325:Nausea / Q000139:chemically induced*
D000932:Antiemetics; C011941:nabilone; D013759:Dronabinol; D008787:Metoclopramide; D002945:Cisplatin