Bulk laxatives: their dietary fibre composition, degradation, and faecal bulking capacity in the rat.
The intestinal dietary fibre degradation and faecal bulking capacity of various bulk laxatives were investigated by means of balance experiments on rats. Nitrogen, fat, and mineral excretion in faeces was also studied. The dietary fibre content of the various bulk laxatives was quite different (in g/kg dry matter): ACO fibre tablets (barley and citrus pulp), 451; Fiberform (wheat bran-based), 817; Inolaxol (sterkulia gum), 696; and Vi-Siblin (ispaghula husk), 533. The increase in faecal dry matter per 1 g dietary fibre was similar with ACO fibre tablets, Fiberform, and Vi-Siblin. Inolaxol gave a significantly (p less than 0.001) higher faecal dry-weight increment, mainly due to an increased mineral excretion. Of the dry-weight increment, 59-82% constituted undegraded dietary fibre. Thus, 68-97% of the fibre passed through the gastrointestinal tract without being degraded. All the bulk laxatives caused a similar increase in the faecal N content, whereas the increase in faecal lipids was most pronounced with Vi-Siblin. The water-holding capacity of faeces was more pronounced with Inolaxol and Vi-Siblin than with ACO fibre tablets and Fiberform.
D000818:Animals; D002400:Cathartics / Q000032:analysis*; D004043:Dietary Fiber / Q000032:analysis* / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D050356:Lipid Metabolism; D008903:Minerals / Q000378:metabolism; D008968:Molecular Conformation; D008970:Molecular Weight; D009584:Nitrogen / Q000378:metabolism; D051381:Rats; D012995:Solubility; D013678:Technology, Pharmaceutical
D002400:Cathartics; D004043:Dietary Fiber; D008903:Minerals; D009584:Nitrogen