Identification of three new Ig lambda-like genes in man.
Three new human lambda L chain-like Ig genes are identified by restriction enzyme and nucleotide sequence analysis. Two genes, 14.1 and 16.1, have intact J and C regions, and are potentially functional, with open reading frames. A third gene, 18.1, is a pseudogene. The evolutionary lineage of these genes compared to the known functional locus lambda C1-lambda C6 can be surmised from Southern blot and nucleotide homologies. This study demonstrates that the human lambda gene family is more complex than previously recognized.
D000595:Amino Acid Sequence; D001483:Base Sequence; D002904:Chromosomes, Human, 21-22 and Y; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005796:Genes; D006801:Humans; D007127:Immunoglobulin Constant Regions / Q000235:genetics; D007144:Immunoglobulin J-Chains / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D007146:Immunoglobulin lambda-Chains / Q000145:classification / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D007127:Immunoglobulin Constant Regions; D007144:Immunoglobulin J-Chains; D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains; D004247:DNA; D004262:DNA Restriction Enzymes