Correlations between T-cell specificity and the structure of the antigen receptor.
The derived amino-acid sequences of the heterodimeric antigen receptors expressed by a series of murine T-cell clones are presented. A comparison of the receptor sequences indicates that several mechanisms for generating receptor diversity can influence T-cell specificity, including junctional diversity, combinatorial joining, and combinatorial chain associations.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002999:Clone Cells / Q000276:immunology; D010856:Columbidae; D003574:Cytochrome c Group / Q000276:immunology; D004247:DNA / Q000235:genetics; D005802:Genes, MHC Class II; D008213:Lymphocyte Activation; D009154:Mutation; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology*; D011995:Recombination, Genetic; D013601:T-Lymphocytes / Q000276:immunology*
D003574:Cytochrome c Group; D011948:Receptors, Antigen, T-Cell; D004247:DNA