Modulation of peripheral benzodiazepine binding sites following chronic estradiol treatment.
A 10 day estradiol treatment of rats resulted in a marked reduction (43%) in peripheral benzodiazepine (BZ) binding sites in the testis and an up-regulation (27%) of these sites in the kidney. No significant alterations in brain central BZ receptors and heart peripheral binding sites were observed. The down-regulation of BZ binding sites in the testis may be related to or accompany estrogen-induced testicular atrophy. The physiological and pharmacological implications of the alterations obtained in the kidney are as yet unclear.
D000818:Animals; D001569:Benzodiazepines / Q000378:metabolism; D001665:Binding Sites; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism; D013737:Testis / Q000187:drug effects / Q000378:metabolism
D011963:Receptors, GABA-A; D001569:Benzodiazepines; D004958:Estradiol