[Binding activity of circulating HBsAg particles for polymerized human albumin in acute hepatitis B].
The binding activity of circulating HBsAg particles to polymerized human serum albumin (pHSA) was determined by radioimmunoassay in 18 patients with acute hepatitis B at follow-up and compared with other hepatitis B virus (HBV) markers. All patients had serum HBsAg particles with binding sites for pHSA during the acute phase of disease. Elimination of HBsAg particles with pHSA receptors occurred within 1 to 8 weeks in uncomplicated courses and in one case with a protracted course of 16 weeks before total elimination of HBsAg. The pHSA-test became negative after elimination of HBsAg in most instances. Three patients developed chronic hepatitis with persistence of pHSA-binding HBsAg particles. Circulating HBcAg dissociated by chaotropic ions was detectable in the first week of observation in 4 of 15 patients who recovered and persisted in 3 cases with transition to chronic disease. The results show that acute hepatitis B is associated with circulating pHSA-binding HBsAg particles which can serve as a prognostic marker of the early phase of the disease.
D000328:Adult; D000368:Aged; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis / Q000276:immunology*; D006512:Hepatitis B Core Antigens / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006513:Hepatitis B e Antigens / Q000276:immunology; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011863:Radioimmunoassay; D017457:Receptors, Albumin; D011956:Receptors, Cell Surface / Q000276:immunology*; D012709:Serum Albumin / Q000276:immunology*; D000075462:Serum Albumin, Human
D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D017457:Receptors, Albumin; D011956:Receptors, Cell Surface; D012709:Serum Albumin; C032137:polyalbumin; D000075462:Serum Albumin, Human
Bindungsaktivität zirkulierender HBsAg-Partikel für polymeres Humanalbumin im Verlauf der akuten Hepatitis B.