Intrastriatal N-methyl-D-aspartate prevents amygdala kindled seizures in rats.
Microinfusion of an excitatory amino acid, N-methyl-D-aspartate, into the ventral mid-striatum in the rat protects from amygdala kindled seizures. This result demonstrates that excitatory activity in the striatum modulates the threshold for seizures in the limbic forebrain.
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects* / Q000502:physiology; D003864:Depression, Chemical; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D016202:N-Methylaspartate; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology; D009435:Synaptic Transmission
D001224:Aspartic Acid; D016202:N-Methylaspartate