Treatment of murine histoplasmosis with UK 49,858 (fluconazole).
Fluconazole was compared with ketoconazole and with amphotericin B in treatment of pulmonary histoplasmosis in immunologically intact mice and in congenitally athymic nude mice. Both fluconazole and amphotericin B increased survival and reduced fungal burden in normal mice. All 3 drugs equally prolonged survival of nude mice challenged with Histoplasma capsulatum, and all effectively reduced the fungal burden. Fluconazole may be a useful antifungal drug in treatment of murine histoplasmosis.
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D015725:Fluconazole; D006660:Histoplasmosis / Q000188:drug therapy*; D007654:Ketoconazole / Q000008:administration & dosage / Q000627:therapeutic use; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008819:Mice, Nude; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; D015725:Fluconazole; D007654:Ketoconazole