Neuroendocrine differentiation in müllerian neoplasms. An immunohistochemical study of a "pure" endometrial small-cell carcinoma and a mixed müllerian tumor containing small-cell carcinoma.
Two neoplasms of the endometrium exhibiting histologic features of small cell carcinoma (SCC) were studied immunohistochemically for the presence of antigens indicative of neuroendocrine differentiation. The first case, a pure SCC, was positive for neuron-specific enolase (NSE), Leu-7, and chromogranin. The second case, a mixed müllerian tumor, had an extensive SCC component; the latter element was reactive for NSE and Leu-7. The first patient has had an unexpectedly long survival, while the second patient died with multiple distant metastases, containing only SCC.
D000368:Aged; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000032:analysis / Q000473:pathology*; D002864:Chromogranins / Q000032:analysis; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000032:analysis / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D014594:Uterine Neoplasms / Q000032:analysis / Q000473:pathology*; D014599:Uterus / Q000473:pathology*
D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D002864:Chromogranins; D010751:Phosphopyruvate Hydratase