title: Biochemical characterization of collagenase activity from middle ear effusions.
abstract: Collagenolytic enzyme activity has been demonstrated in middle ear effusions from patients suffering from otitis media with effusion. Collagenase activity was characterized using different biochemical techniques. The enzyme was found to have a higher specific activity in mucoid effusions and had characteristics similar to granulocyte derived collagenase from human leucocytes.
mesh_terms: D002908:Chronic Disease; D005122:Exudates and Transudates / Q000201:enzymology*; D006801:Humans; D003012:Microbial Collagenase / Q000378:metabolism*; D010034:Otitis Media with Effusion / Q000201:enzymology*; D012008:Recurrence
chemical_list: D003012:Microbial Collagenase