title: [Preparation of diagnostic sera to enteroviruses 69, 70 and 71 having medical importance].
abstract: The use of enteroviruses, types 69, 70 and 71, purified with freon and concentrated with polyethylene glycol, for immunizing rabbits, following 4 immunization schedules, has made it possible to obtain active virus-neutralizing diagnostic sera with antibody titers of up to 1:2560, 1:806 and 1:9123, respectively.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000276:immunology / Q000302:isolation & purification; D004306:Dose-Response Relationship, Immunologic; D004770:Enterovirus / Q000276:immunology* / Q000302:isolation & purification; D007106:Immune Sera / Q000032:analysis / Q000276:immunology / Q000302:isolation & purification*; D007114:Immunization / Q000379:methods; D009500:Neutralization Tests; D011817:Rabbits; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D007106:Immune Sera
vernacular_title: Prigotovlenie diagnosticheskikh syvorotok k énterovirusam 69, 70 i 71, imeiushchim meditsinskoe znachenie.