title: Quantitative determination of acivicin in bulk drug and pharmaceutical formulations by ion-pair high-performance liquid chromatography.
abstract: An ion-pair reversed-phase high-performance liquid chromatographic method for the determination of the purity of acivicin and the amount of drug in a sterile powder and two sterile solution formulations is described. The method displays good recoveries (98.4-100.4%) for all formulations and a linear range of 0.002-20 micrograms of drug injected. Estimates of assay precision were 1.3% for the bulk drug, 0.6% for sterile solution formulations and 1.6% for the sterile powder formulations.
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis*; D019905:Benzyl Alcohol; D001592:Benzyl Alcohols; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D007555:Isoxazoles / Q000032:analysis*; D010080:Oxazoles / Q000032:analysis*; D010472:Perchlorates; D011208:Powders; D012996:Solutions
chemical_list: D000970:Antineoplastic Agents; D001592:Benzyl Alcohols; D007555:Isoxazoles; D010080:Oxazoles; D010472:Perchlorates; D011208:Powders; D012996:Solutions; D019905:Benzyl Alcohol; C006303:acivicin