Histopathological studies on experimental murine salivary gland tumours treated with adriamycin: evidence for an anti-myoepithelial cell action.
Mice bearing pleomorphic salivary tumours induced by polyoma virus underwent chemotherapy with Adriamycin. Animals were killed at 2 day intervals and the tumours examined histologically. Two days after a single dose of Adriamycin, gross vacuolation degeneration was seen around ductal cells at sites corresponding to myoepithelial cells. At subsequent time periods there was progressive degeneration of other tumour elements. It is proposed that myoepithelial cell death in salivary gland tumours induced by Adriamycin may be an important factor in the early response of this tumour to chemotherapy.
D008949:Adenoma, Pleomorphic / Q000188:drug therapy / Q000473:pathology*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D011120:Polyomavirus; D012468:Salivary Gland Neoplasms / Q000188:drug therapy / Q000473:pathology*; D013997:Time Factors; D014412:Tumor Virus Infections / Q000188:drug therapy / Q000473:pathology
D004317:Doxorubicin