Epidermal hyperproliferation following the induction of microabscesses by leukotriene B4.
The percentage of non-diploid epidermal cells was determined by flow cytometry following application of leukotriene B4 (LTB4) to human skin. Doses in the range 35-500 ng were shown to cause a marked increase in proliferation, the non-diploid cells reaching a maximum between 72 and 96 h after LTB4 application. No difference was observed between the response of healthy controls and the uninvolved skin of psoriatic patients. We suggest, therefore, that the hyperproliferation is a consequence of the physical disruption of the stratum corneum accompanying the rupture of microabscesses.
D000038:Abscess / Q000139:chemically induced / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D004817:Epidermis / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D007975:Leukotriene B4 / Q000494:pharmacology*; D011565:Psoriasis / Q000473:pathology*; D012871:Skin Diseases / Q000139:chemically induced / Q000473:pathology
D007975:Leukotriene B4