[Protein phosphorylation and inositol phospholipid metabolism in activated rat mast cells].
The interactions of rat mast cells with a variety of stimuli results in the secretion of a number of mediators through intracellular biochemical events. Calcium and cyclic AMP appear to be two major biochemical factors for the control of cellular activities and are known to activate protein kinases. Another line of evidence indicates that extracellular stimuli induce phospholipid turnover in their target cells. in this article, the author reviews protein phosphorylation and phospholipid metabolism, especially that of inositol phospholipid, during mediator release from stimulated rat mast cells.
D000818:Animals; D002118:Calcium / Q000502:physiology; D002147:Calmodulin / Q000502:physiology; D004205:Cromolyn Sodium / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology; D006152:Cyclic GMP / Q000378:metabolism; D066298:In Vitro Techniques; D007294:Inositol / Q000378:metabolism; D008407:Mast Cells / Q000378:metabolism*; D008745:Methylation; D010743:Phospholipids / Q000378:metabolism*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology
D002147:Calmodulin; D010743:Phospholipids; D011506:Proteins; D011956:Receptors, Cell Surface; D007294:Inositol; D000242:Cyclic AMP; D011494:Protein Kinases; D011493:Protein Kinase C; D006152:Cyclic GMP; D004205:Cromolyn Sodium; D002118:Calcium