Regulation of central alpha-adrenoceptors by serotoninergic denervation.
Alpha 1- and alpha 2-adrenoceptors were assessed by binding studies using [3H]prazosin and [3H]p-aminoclonidine as ligands in membrane preparations from the cortex, hippocampus and hypothalamus of rats, 3 weeks after intracerebroventricular injection of the neurotoxin 5,7-dihydroxytryptamine. Cortical alpha 1 and hippocampal alpha 2 adrenoceptors were significantly increased. Treatment also affected the affinity of cortical alpha 2 adrenoceptors. These results suggest a heterologous, region-specific regulation of both subtypes of central alpha-adrenergic receptors by serotonin.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology; D003000:Clonidine / Q000031:analogs & derivatives / Q000378:metabolism; D006624:Hippocampus / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D011224:Prazosin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D012701:Serotonin / Q000502:physiology*
D011942:Receptors, Adrenergic, alpha; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; C016986:apraclonidine; D003000:Clonidine; D011224:Prazosin