title: Regions associated with the stable maintenance of plasmid pSC101 and its tetracycline resistance.
abstract: Two regions tentatively called unsA and unsR were identified on pSC101. One, unsA, corresponds to less than 650 bp of the N-terminal in the tetracycline resistance structural gene and seems to inhibit stable maintenance of pSC101. The other, unsR, is defined within the 1 kb XhoI-EcoRI region located upstream of the tetracycline resistance structural gene and is a regulatory gene clearly distinct from tetR (Unger et al. 1984); it serves as a suppressor of the unsA function.
mesh_terms: D004262:DNA Restriction Enzymes; D004251:DNA Transposable Elements; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D009154:Mutation; D010957:Plasmids; D011815:R Factors; D013752:Tetracycline / Q000494:pharmacology*
chemical_list: D004251:DNA Transposable Elements; D004262:DNA Restriction Enzymes; D013752:Tetracycline