Acute sodium bicarbonate does not affect renal hemodynamics in splenectomized dogs.
The glomerular filtration rate and the renal plasma flow were measured in conscious splenectomized dogs. The rapid intravenous administration of sodium bicarbonate (0.21 g . kg-1) did not affect either the glomerular filtration rate or the renal plasma flow.
D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D004285:Dogs; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D012079:Renal Circulation / Q000187:drug effects*; D012964:Sodium / Q000494:pharmacology*; D017693:Sodium Bicarbonate; D012965:Sodium Chloride / Q000494:pharmacology; D013156:Splenectomy
D001639:Bicarbonates; D012965:Sodium Chloride; D017693:Sodium Bicarbonate; D012964:Sodium