Hepatocellular carcinoma related to hepatitis B virus in a patient with Waldenström's macroglobulinemia.
A patient with long-standing Waldenström's disease and cryoglobulinemia, treated with chlorambucil, developed hepatocellular carcinoma. Although HBs antigen, anti-HBs, and anti-HBc antibodies were not detected in his serum by conventional polyclonal radioimmunoassays, immunofluorescence techniques showed HBs antigen to be present in hepatocytes.
D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000276:immunology; D006509:Hepatitis B / Q000150:complications*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D008099:Liver / Q000276:immunology; D008113:Liver Neoplasms / Q000209:etiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008258:Waldenstrom Macroglobulinemia / Q000150:complications*
D006514:Hepatitis B Surface Antigens