[Effect of thiamine on neuromuscular transmission in the frog].
The action of thiamine on frog m. sartorius neuromuscular junction was investigated. Thiamine (1 X 10(-14)-1 X 10(-4) mol/l) reversibly increased miniature end-plate potential frequency, amplitude and quantal content of end-plate potentials, probability of quantal release. The role of thiamine in the regulation of synaptic transmission and mechanism of its action are discussed.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001001:Anura; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009045:Motor Endplate / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*; D013831:Thiamine / Q000494:pharmacology* / Q000502:physiology
D000109:Acetylcholine; D013831:Thiamine
Deĭstvie tiamina na nervno-myshechnuiu peredachu u liagushki.