Variant translocation t(7;922) during lymphoid blastic crisis in a case of Ph1-positive chronic myelogenous leukemia with previous EBV infection.
We report the case of a 19-year-old girl in whom a Ph1-positive chronic myeloid leukemia was diagnosed 10 months after an episode of infectious mononucleosis. Clinical and cytogenetical follow-up demonstrated the appearance of a variant Philadelphia chromosome translocation t(7;9;22) during a blastic crisis characterized by early B-lymphoid elements. The association between the t(7;9;22) variant Philadelphia and the lymphoid blast cells is emphasized, and the importance of Epstein-Barr virus (EBV) infection in the pathogenesis of the disease in this case is discussed.
D000328:Adult; D002871:Chromosome Banding; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications / Q000235:genetics*; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic; D014412:Tumor Virus Infections / Q000150:complications*