A catalyst function for MPTP in superoxide formation.
We demonstrate that 1-methyl-4-phenyl-1,2-dihydropyridine (MPDP) can be generated, in an alternate pathway, from the catalyst action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) upon the iron redox equilibrium reaction. Superoxide and ferric iron are instantaneously produced after addition of MPTP to a solution of ferrous iron. This reaction is oxygen and pH dependent. Superoxide, through a iron dependent Haber-Weiss reaction with peroxide, can generate the cytotoxic hydroxyl radical. A small portion of the superoxide reacts with MPTP to produce the reactive species X. which, in the presence of Fe+3 can also generate MPDP.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D002384:Catalysis; D003676:Deferoxamine; D005609:Free Radicals; D006863:Hydrogen-Ion Concentration; D007501:Iron; D007700:Kinetics; D010084:Oxidation-Reduction; D010100:Oxygen; D011725:Pyridines; D013053:Spectrophotometry; D013481:Superoxides
D005609:Free Radicals; D011725:Pyridines; D013481:Superoxides; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D007501:Iron; D003676:Deferoxamine; D010100:Oxygen