title: Papillomavirus DNA in human tongue carcinomas.
abstract: Seven biopsies from different carcinomas of the tongue were analyzed for human papilloma virus (HPV) sequences by Southern blot analysis. After hybridization with various types of human papilloma viruses, 3 tumors were found to be positive. Whereas DNA from one tumor hybridized with HPV 2 DNA under conditions of high stringency, the 2 other positive biopsies contained HPV 16 DNA. All positive tumors revealed high copy numbers of the respective DNA. The cleavage pattern of the HPV-2-positive tumor differed from the established HPV 2 prototypes. Minor differences from the HPV 16 prototype were also noted in one of the HPV-16-positive tongue carcinomas.
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000382:microbiology* / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis*; D006801:Humans; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000235:genetics*; D014062:Tongue Neoplasms / Q000382:microbiology* / Q000473:pathology
chemical_list: D004279:DNA, Viral