[Role of active vitamin D3 metabolites in regulating calcium metabolism in rats during hypokinesia].
The rats exposed to prolonged hypokinesia showed hypocalciemia, lower PTH and higher calcitonin concentrations in the serum, decreased calcium absorption in the small intestine, and a trend toward nephro- and arteriocalcinosis. Prophylactic administration of 24,25-hydroxy D3. 1,25-hydroxy D3 and their combinations enhanced calcium absorption and alleviated hypocalciemia. The changes in the hormonal regulation of calcium homeostasis can be viewed as a factor responsible for calcium metabolic disorders associated with hypokinesia.
D015650:24,25-Dihydroxyvitamin D 3; D000818:Animals; D001011:Aorta / Q000378:metabolism; D001692:Biological Transport; D002117:Calcitriol / Q000008:administration & dosage / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002762:Cholecalciferol / Q000008:administration & dosage / Q000378:metabolism*; D004100:Dihydroxycholecalciferols / Q000008:administration & dosage / Q000378:metabolism; D004386:Duodenum / Q000378:metabolism; D006706:Homeostasis / Q000187:drug effects; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004100:Dihydroxycholecalciferols; D002762:Cholecalciferol; D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol; D002118:Calcium
Rol' aktivnykh metabolitov vitamina D3 v reguliatsii obmena kal'tsiia u krys pri gipokinezii.