Structural alterations of the human erythrocyte membrane upon influenza virus attachment.
Molecular events on the human erythrocyte membrane subsequent to influence virus binding were investigated by electron spin resonance (ESR) measurements after spin labeling of the cell membrane at different positions. Virus binding affected the glycocalyx structure as well as the physical state of the cytoskeleton at the inner leaflet, but not the lipid phase. A lateral reorganization of spin-labeled glycophorin was not indicated after virus attachment.
D000042:Absorption; D001287:Attachment Sites, Microbiological; D002459:Cell Fusion; D003497:Cyclic N-Oxides; D003599:Cytoskeleton / Q000378:metabolism / Q000648:ultrastructure; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000648:ultrastructure*; D006023:Glycoproteins / Q000032:analysis; D006461:Hemolysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008560:Membrane Fluidity; D008854:Microscopy, Electron; D009975:Orthomyxoviridae / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D011134:Polysaccharides / Q000032:analysis; D013113:Spin Labels; D013696:Temperature
D003497:Cyclic N-Oxides; D006023:Glycoproteins; D011134:Polysaccharides; D013113:Spin Labels; C017480:4-maleimido-2,2,6,6-tetramethylpiperidinooxyl