Cellular reactions during drug-induced cleft palate.
Responses of the epithelial and mesenchymal cells of the developing hamster secondary palate to hadacidin, 5-fluorouracil, and hydrocortisone were analysed. Correlation of data on cellular response with morphological and biochemical observations suggested that several aspects of differentiation of palatal cells needs to be analysed before pathogenesis of teratogen-induced cleft palate can be defined.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced*; D006224:Cricetinae; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D005865:Gestational Age; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology; D010160:Palate, Soft / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism; D011247:Pregnancy; D013723:Teratogens
D013723:Teratogens; C001321:hadacidin; D000242:Cyclic AMP; D000135:Acid Phosphatase; D005998:Glycine; D005472:Fluorouracil; D006854:Hydrocortisone