[Proof of diaplacental transmission of HTLV III/LAV before the 20th week of pregnancy].
Tissue samples were taken from a 20-week old foetus in a mother with positive LAV/HTLV-III reaction without clinical or immunological signs of AIDS. These samples were used for cocultivation of LAV/HTLV-III. This resulted in inducing in MT-2 cells a cytopathic effect characteristic for LAV/HTLV-III infections, induced by thymus, spleen, lungs and brain tissue of the foetus after cocultivation with umbilical cord lymphocytes; in H-9 and MT-2 cells this led to the expression and release of antigens reacting with LAV/HTLV-III-specific anti-bodies. This observation shows that intrauterine infection of the foetus must have occurred already before the 20th week of gestation; the same target cells are involved via uterine transmission as via postnatal infection, i.e. cells of the lymphatic system and of the CNS.
D000028:Abortion, Induced; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000635:transmission*; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D017977:Deltaretrovirus / Q000276:immunology / Q000472:pathogenicity; D005260:Female; D015483:HIV Antibodies; D006556:Heroin Dependence / Q000150:complications; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000382:microbiology*; D011262:Pregnancy Trimester, Second; D012192:Retroviridae Infections / Q000276:immunology / Q000635:transmission*
D000914:Antibodies, Viral; D015483:HIV Antibodies
Nachweis einer diaplazentaren Ubertragung von HTLV-III/LAV vor der 20. Schwangerschaftswoche.