Aspects of psoralen phototumorigenesis with emphasis on the possible role of tumour promotion.
8-Methoxypsoralen in combination with UVA radiation (PUVA) is carcinogenic in mice and probably so in man. PUVA is genotoxic and so has tumour initiation potential. Some evidence suggests that PUVA has other biological effects which may be equated with tumour promotion. Thus, the use of a two-stage model, similar to that of chemical carcinogenesis, may be a useful experimental approach for the further understanding of PUVA carcinogenesis.
D000818:Animals; D003432:Cross-Linking Reagents; D004247:DNA / Q000378:metabolism; D011564:Furocoumarins / Q000009:adverse effects*; D008730:Methoxsalen / Q000009:adverse effects; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000378:metabolism; D009955:Ornithine Decarboxylase / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D011701:PUVA Therapy / Q000009:adverse effects; D010777:Photochemistry; D026082:Singlet Oxygen; D012878:Skin Neoplasms / Q000139:chemically induced; D013481:Superoxides / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate; D014466:Ultraviolet Rays
D003432:Cross-Linking Reagents; D011564:Furocoumarins; D013481:Superoxides; D026082:Singlet Oxygen; D004247:DNA; C017104:3-carbethoxypsoralen; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate; D010100:Oxygen; D008730:Methoxsalen