Iodized oil treatment for endemic goiter does not induce the surge of positive serum concentrations of anti-thyroglobulin or anti-microsomal autoantibodies.
Forty-three goitrous patients (grade II and III, WHO classification), living in areas of chronic iodine deficiency, were treated with an injection of iodized oil (470 mg iodine). Serial measurements of serum thyroid hormone levels after the therapy revealed increasing concentrations of both hormones, with a significantly lower serum T3/T4 ratio, and progressively significantly lower serum TSH mean values. Serum Tg mean value, initially elevated (58 +/- 9 ng/ml), decreased after 6 months and returned to the normal range at 36 months of therapy. In none of the examined patients (except for one subject with positive autoantibodies before therapy), it was observed the surge of positive anti-thyroglobulin or anti-microsomal autoantibodies after the iodized oil. We conclude that iodized oil therapy does not induce an abnormal autoimmune reaction in endemic goiter patients.
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000096:biosynthesis*; D005260:Female; D006043:Goiter, Endemic / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007459:Iodized Oil / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008861:Microsomes / Q000276:immunology; D008875:Middle Aged; D013954:Thyroglobulin / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology; D013963:Thyroid Hormones / Q000097:blood; D013967:Thyroiditis, Autoimmune / Q000209:etiology
D001323:Autoantibodies; D013963:Thyroid Hormones; D007459:Iodized Oil; D013954:Thyroglobulin