Collagenase digestion alters the organization and turnover of junctional acetylcholine receptors.
Acetylcholine receptors at the vertebrate neuromuscular junction are highly organized and metabolically very stable. We report here that digestion of adult rat skeletal muscle with collagenase disorganizes junctional receptors and increases their turnover rate.
D000818:Animals; D003964:Diaphragm / Q000294:innervation; D006652:Histological Techniques; D003012:Microbial Collagenase / Q000494:pharmacology*; D009045:Motor Endplate / Q000648:ultrastructure; D009469:Neuromuscular Junction / Q000378:metabolism*; D009994:Osmolar Concentration; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000378:metabolism*
D011950:Receptors, Cholinergic; D003012:Microbial Collagenase