title: [Regulation of EGF receptor by tumor promoters].
abstract: Regulation of the EGF receptor system by tumor promoters Nobuyoshi Shimizu (Dept. of Mol. Biol., Keio Univ. Sch. Med.) EGF inhibits the growth of several tumor cell lines that possess extremely high numbers of EGF receptors. The growth of some of these cell lines is also inhibited by the tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) while others are insensitive to TPA. We have isolated variants from these cells that are no longer affected by EGF and/or TPA. Initial characterization of these cell variants is presented with regard to the TPA-directed regulation of the EGF receptor system.
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology*; D002460:Cell Line; D066246:ErbB Receptors; D005347:Fibroblasts; D006801:Humans; D051379:Mice; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000473:pathology; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D013755:Tetradecanoylphorbol Acetate
chemical_list: D011956:Receptors, Cell Surface; D066246:ErbB Receptors; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate