Induction of gastric carcinomas in nonhuman primates by N-ethyl-N'-nitro-N-nitrosoguanidine.
N-Ethyl-N'-nitro-N-nitrosoguanidine [(ENNG) CAS: 63885-23-4] was administered to 5 Macaca monkeys (Macaca mulatta and M. irus) at a concentration of 200 or 300 micrograms/ml for 11-26 months in their drinking water. Gastric carcinomas in the pyloric region were observed in all 5 monkeys between experimental months 11 and 38. Histologically, these carcinomas were mainly poorly differentiated adenocarcinomas and signet-ring cell carcinomas, and a few moderately and well-differentiated adenocarcinomas were also found. The macroscopic and histologic appearances of these carcinomas were similar to those in humans.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology / Q000648:ultrastructure; D002288:Adenocarcinoma, Mucinous / Q000139:chemically induced* / Q000473:pathology / Q000648:ultrastructure; D000818:Animals; D005260:Female; D005266:Femoral Neoplasms / Q000139:chemically induced; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000031:analogs & derivatives* / Q000633:toxicity; D012516:Osteosarcoma / Q000139:chemically induced; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000648:ultrastructure; D014134:Tracheal Neoplasms / Q000139:chemically induced
D008769:Methylnitronitrosoguanidine; C013525:ENNG