In vitro inhibition of renal sodium-potassium ATPase activity by progesterone.
The effect of various steroids and prostaglandins on the activity of canine kidney Na+, K+-ATPase activity was tested in vitro. Progesterone induced a dose-dependent increase in inhibition of the canine kidney Na+, K+-ATPase activity. Aldosterone, cortisol, cortisone as well as prostaglandin E2 and 13,14-dihydro-15-keto-prostaglandin F2 alpha, did not cause an inhibition of canine kidney Na+, K+-ATPase.
D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007668:Kidney / Q000201:enzymology*; D011374:Progesterone / Q000494:pharmacology*; D011453:Prostaglandins / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
D011453:Prostaglandins; D000450:Aldosterone; D011374:Progesterone; D000254:Sodium-Potassium-Exchanging ATPase