title: Slow synaptic transmission in frog sympathetic ganglia.
abstract: Bullfrog ganglia contain two classes of neurone, B and C cells, which receive different inputs and exhibit different slow synaptic potentials. B cells, to which most effort has been directed, possess slow and late slow EPSPs. The sEPSP reflects a muscarinic action of acetylcholine released from boutons on B cells, whereas the late sEPSP is caused by a peptide (similar to teleost LHRH) released from boutons on C cells. During either sEPSP there is a selective reduction in two slow potassium conductances, designated 'M' and 'AHP'. The M conductance is voltage dependent and the AHP conductance is calcium dependent. Normally they act synergistically to prevent repetitive firing of action potentials during maintained stimuli. Computer stimulation of the interactions of these conductances with the other five voltage-dependent conductances present in the membrane allows a complete reconstruction of the effects of slow synaptic transmission on electrical behaviour.
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D002118:Calcium / Q000494:pharmacology; D003201:Computers; D005071:Evoked Potentials / Q000187:drug effects; D005728:Ganglia, Sympathetic / Q000166:cytology / Q000502:physiology*; D008959:Models, Neurological; D011892:Rana catesbeiana; D013569:Synapses / Q000166:cytology / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D002118:Calcium