[Cytomegalovirus infections after kidney transplantation and passive immunization].
Cytomegalovirus infection after renal transplantation impairs the survival rate of patient and graft. An incidence of 24 to 92% of CMV infections after renal transplantation is reported, but only 15 to 77% of these patients show clinical symptoms. Contaminated donor organs, blood transfusions and reactivation by immunosuppression are the main causes of this infection. Active immunisation cannot prevent the reactivation of the infection, but also antiviral agents can hardly influence the course of the disease. Passive immunisation showed promising effects in bone-marrow transplantation and is now also tried in renal transplantation. The first results of a randomized study do not allow a final conclusion, but show less clinical symptomatic CMV infections, and statistically significant less herpes simplex infections in the group receiving anti CMV IgG prophylaxis.
D000914:Antibodies, Viral; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000517:prevention & control*; D006085:Graft Survival; D006801:Humans; D007116:Immunization, Passive; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation; D008017:Life Expectancy
D000914:Antibodies, Viral
Zytomegalievirusinfektionen nach Nierentransplantationen und passive Immunisierung.