Human T-cell lymphotropic virus type III (HTLV-III) embryopathy. A new dysmorphic syndrome associated with intrauterine HTLV-III infection.
Twenty infants and children with positive serologic tests for the human T-cell lymphotropic virus type III (HTLV-III) were noted to have similar features including growth failure (75%), microcephaly (70%), and craniofacial abnormalities consisting of ocular hypertelorism (50%); prominent box-like appearance of the forehead (75%); flat nasal bridge (70%); mild upward or downward obliquity of the eyes (65%); long palpebral fissures with blue sclerae (60%); short nose with flattened columella and well-formed, triangular philtrum (65%); and patulous lips (60%). These features constitute a new and distinct dysmorphic syndrome, the HTLV-III embryopathy.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000151:congenital*; D000886:Anthropometry; D000914:Antibodies, Viral / Q000032:analysis*; D002675:Child, Preschool; D017977:Deltaretrovirus / Q000276:immunology; D005147:Facial Bones / Q000002:abnormalities*; D005260:Female; D005315:Fetal Diseases / Q000382:microbiology*; D005317:Fetal Growth Retardation / Q000209:etiology; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D011247:Pregnancy; D012192:Retroviridae Infections / Q000382:microbiology*; D012886:Skull / Q000002:abnormalities*
D000914:Antibodies, Viral