title: The etiology of underlying liver lesions in 70 autopsied cases of hepatocellular carcinoma.
abstract: In 70 patients with hepatocellular carcinoma without history of antineoplastic chemotherapeutic drugs, anabolic and contraceptive steroids, representative sections of nonneoplastic liver tissue were examined for the presence of etiological markers. Hepatitis B surface antigen-positive hepatocytes were found in 16 (22.8%), alpha-1-antitrypsin globules in 3 (4.2%), Mallory bodies in 9 (12.8%), acicular inclusions in 1 (1.4%), diffuse giant mitochondria in 2 (2.8%), copper-binding protein in 25 (35.7%), greater amount of hemosiderin in 9 (12.8%) cases. Thorotrast was not detected. One or more markers were seen in 38 (54.3%) cases, most frequently in association with liver cell dysplasia and alcoholism. The presence of hepatitis B surface antigen in livers with dysplastic foci was highly significant as compared to organs showing no dysplasia. Only the mentioned antigen and the alpha-1-antitrypsin globules were found to indicate the etiology of the underlying liver lesion. The value of the other markers was found inconsistent in etiological diagnosis.
mesh_terms: D000293:Adolescent; D000368:Aged; D000437:Alcoholism / Q000150:complications; D001344:Autopsy; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000473:pathology; D002570:Ceruloplasmin / Q000032:analysis; D002648:Child; D005260:Female; D006485:Hemosiderin / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D006514:Hepatitis B Surface Antigens; D000515:alpha 1-Antitrypsin; D006485:Hemosiderin; D002570:Ceruloplasmin