Alpha 2-receptor control over release of noradrenaline in rat thalamus.
Rat brain thalamic tissue was examined for the presence of alpha 2-receptor control over noradrenaline (NA) utilization. Systemically administered clonidine (0.1 mg/kg i.p.) decreased NA turnover, yohimbine (10 mg/kg i.p.) increased NA turnover, and prazosin (0.5 mg/kg i.p.) had no effect. In vitro, yohimbine increased K+-stimulated overflow of endogenous NA in a dose-dependent fashion. It appears that locus coeruleus neurons which project to thalamus exhibit the same type of alpha 2-receptor control as those terminating in other forebrain regions.
D000818:Animals; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D013788:Thalamus / Q000378:metabolism*; D015016:Yohimbine / Q000494:pharmacology
D011942:Receptors, Adrenergic, alpha; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; D015016:Yohimbine; D003000:Clonidine; D011188:Potassium; D009638:Norepinephrine; D011224:Prazosin