Serum levels of vitamin D metabolites in children receiving total parenteral nutrition.
Serum levels of 25-hydroxyvitamin D (25-OHD) and 1,25-dihydroxyvitamin D (1,25-(OH)2D) were measured on 19 occasions in seven children receiving total parenteral nutrition (TPN). The daily intakes of vitamin D3 ranged from 44 to 540 IU/day, and all serum samples were obtained after the same daily intake of vitamin D3 for more than 1 month. There was a significant positive correlation between serum 25-OHD levels and parenteral vitamin D3 intakes (r = 0.90, p less than 0.01). In this study, serum 25-OHD levels in all cases taking 200 to 360 IU/day of vitamin D3 were within the normal range. On the other hand, no significant correlation was found between serum 1,25-(OH)2D levels and vitamin D3 intakes, and serum 1,25-(OH)2D levels were normal or elevated in all cases.
D002112:Calcifediol / Q000097:blood*; D002117:Calcitriol / Q000097:blood*; D002675:Child, Preschool; D002762:Cholecalciferol / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009751:Nutritional Requirements; D010289:Parenteral Nutrition, Total / Q000009:adverse effects; D012279:Rickets / Q000209:etiology / Q000517:prevention & control
D002762:Cholecalciferol; D002117:Calcitriol; D002112:Calcifediol