Curare can reverse the failure in muscle contraction caused by an AChE inhibitor.
Diisopropyl fluorophosphate, which is an organophosphate inhibitor of acetylcholinesterase, caused an irreversible block of neuromuscular transmission in the rat diaphragm preparation. This block could be reversed by the addition of a competitive antagonist of acetylcholine such as D-tubocurarine.
D000818:Animals; D007531:Isoflurophate / Q000037:antagonists & inhibitors*; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects*; D014403:Tubocurarine / Q000494:pharmacology*
D007531:Isoflurophate; D014403:Tubocurarine