Aminophylline shortens thiopental sleep-time and enhances noradrenergic neurotransmission in rats.
We investigated the effect of aminophylline on thiopental sleep-times and monoamine neurotransmitter turnover rates in discrete brain areas. Aminophylline-treated rats had shorter thiopental sleep-times than saline-treated controls. Noradrenergic neurotransmission was greater following aminophylline treatment in thiopental-anesthetized rats in all brain areas while turnover in other monoaminergic pathways was unchanged. These data suggest that acute aminophylline treatment increases central noradrenergic neurotransmission which pharmacodynamically diminishes the hypnotic response to thiopental.
D000628:Aminophylline / Q000494:pharmacology*; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D012890:Sleep / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*; D013874:Thiopental / Q000037:antagonists & inhibitors*
D001679:Biogenic Amines; D000628:Aminophylline; D012701:Serotonin; D013874:Thiopental; D004298:Dopamine; D009638:Norepinephrine