Diabetic Chinese hamsters: metabolic effects of long term guar gum consumption.
The effect of 13 weeks of guar gum or cellulose diet consumption upon metabolic parameters was examined in diabetic and control adult Chinese hamsters. Diabetic hamsters displayed typical diabetic metabolic profiles. Both 8% guar gum and 8% cellulose diets maintained body weights in all 4 groups during the study. Diabetic and control hamsters fed guar gum drank less water as the study progressed. At weeks 9 and 13, diabetic hamsters fed guar gum excreted less urine compared to those fed cellulose. Diabetic hamsters fed guar gum had reduced urinary glucose excretion at weeks 1, 9 and 13 compared to those fed cellulose. Control hamsters fed either diet had normal urine volumes with only traces of glucose. Similar fasting plasma glucose levels were measured initially for all diabetic hamsters; all 3 subsequent measurements revealed lower levels for the group fed guar gum. Control hamsters had normal fasting plasma glucose levels. Comparable fasting plasma insulin levels were measured for all diabetic hamsters; these levels increased during the study. Control hamster fasting plasma insulin levels were 3 times higher and did not change. Throughout the study, diabetic hamsters fed guar gum consistently had healthier metabolic profiles than those fed cellulose.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002482:Cellulose / Q000627:therapeutic use; D006224:Cricetinae; D003412:Cricetulus; D003921:Diabetes Mellitus, Experimental / Q000178:diet therapy* / Q000378:metabolism; D003927:Diet, Diabetic; D004043:Dietary Fiber / Q000627:therapeutic use*; D005685:Galactans / Q000627:therapeutic use*; D006029:Glycosuria / Q000175:diagnosis; D007328:Insulin / Q000097:blood; D008297:Male; D008351:Mannans / Q000627:therapeutic use*; D053149:Plant Gums; D013997:Time Factors
D001786:Blood Glucose; D004043:Dietary Fiber; D005685:Galactans; D007328:Insulin; D008351:Mannans; D053149:Plant Gums; D002482:Cellulose; C007894:guar gum