Enhancement of gamma-aminobutyric acid receptor binding by protopine-type alkaloids.
Protopine, cryptopine and allocryptopine were demonstrated to enhance 3H-gamma-aminobutyric acid (3H-GABA) binding to rat brain synaptic membrane receptors. The above finding might be indicative of benzodiazepine-like activity of these alkaloids.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D053119:Benzophenanthridines; D001600:Berberine Alkaloids; D003975:Diazepam / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects*; D013570:Synaptic Membranes / Q000187:drug effects
D000470:Alkaloids; D053119:Benzophenanthridines; D001600:Berberine Alkaloids; D011963:Receptors, GABA-A; D003975:Diazepam; C009093:protopine