title: A new strategy for mapping the human genome.
abstract: Recent advances in agarose gel electrophoresis of large DNA fragments raise the possibility of an entirely new approach to mapping mammalian genomes. In this article is discussed the potential of this technology for tackling problems such as construction of linkage maps, identifying chromosome translocation breakpoints, and moving from linked markers to genes causing diseases such as the muscular dystrophies and Huntington's chorea.
mesh_terms: D002874:Chromosome Mapping; D002877:Chromosomes, Human / Q000502:physiology*; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D004587:Electrophoresis, Agar Gel; D005796:Genes; D030342:Genetic Diseases, Inborn / Q000235:genetics; D008040:Genetic Linkage; D006801:Humans
chemical_list: D004247:DNA; D004262:DNA Restriction Enzymes