title: Glutathione metabolism in red cell aging.
abstract: Normal human red cells were centrifugally separated according to age by discontinuous density gradient of Percoll. Reduced glutathione (GSH), GSH stability and glucose-6-phosphate dehydrogenase (G6PD) activity in fractionated red cells decreased with age, while oxidized glutathione (GSSG) and methemoglobin (MetHb) increased with age.
mesh_terms: D000328:Adult; D002469:Cell Separation / Q000379:methods; D002499:Centrifugation, Density Gradient / Q000379:methods; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005978:Glutathione / Q000031:analogs & derivatives / Q000097:blood*; D019803:Glutathione Disulfide; D006801:Humans; D008297:Male; D008706:Methemoglobin / Q000378:metabolism; D011205:Povidone; D012822:Silicon Dioxide
chemical_list: C016039:Percoll; D012822:Silicon Dioxide; D008706:Methemoglobin; D005954:Glucosephosphate Dehydrogenase; D011205:Povidone; D005978:Glutathione; D019803:Glutathione Disulfide