Intranuclear vacuoles in Creutzfeldt-Jakob disease.
In an electron microscopic study of brain biopsy material from a case with Creutzfeldt-Jakob disease intranuclear vacuoles containing membrano-vesicular structures were found. To our knowledge this finding has not been previously reported in human spongiform encephalopathies. It may represent a specific alteration associated with Creutzfeldt-Jakob disease, and suggests the possibility of nuclear infection.
D001706:Biopsy; D002467:Cell Nucleus / Q000648:ultrastructure; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology*; D005625:Frontal Lobe / Q000648:ultrastructure*; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D014617:Vacuoles / Q000648:ultrastructure