title: Behavioral recovery following kainic acid lesions and fetal implants of the striatum occurs independent of dopaminergic mechanisms.
abstract: Transplantation of fetal striatal tissue into rats with kainic acid lesions of the striatum reversed the spontaneous locomotor abnormalities caused by the lesions, but had no effect on the lesion-induced hyperactivity that followed amphetamine or apomorphine injection. Conversely, transplants into intact (non-lesioned) striatum led to abnormalities in spontaneous locomotion, but did not effect locomotion under amphetamine or apomorphine conditions. Dopamine autoradiography found a relative absence of dopamine receptors within the transplants. These results suggest that the mechanism which accounts for transplant-induced recovery of spontaneous locomotion is independent of striatal dopamine mechanisms.
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000628:therapy; D003342:Corpus Striatum / Q000378:metabolism / Q000637:transplantation*; D004298:Dopamine / Q000502:physiology*; D005260:Female; D005333:Fetus; D007608:Kainic Acid; D009069:Movement Disorders / Q000628:therapy*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism; D009435:Synaptic Transmission
chemical_list: D011954:Receptors, Dopamine; D007608:Kainic Acid; D004298:Dopamine