[Varying nature of the cell receptors for influenza and para-influenza viruses].
A comparative study of receptors for influenza virus, fowl plague virus, and human parainfluenza type 3 virus was carried out. Natural receptors of guinea pig erythrocytes were destroyed with neuraminidase, and individual gangliosides GM1, GD1a, and GT1b were inserted into their membranes. The labeled virus was adsorbed on the erythrocytes modified in this manner, and the degree of restoration of the receptor activity of erythrocytes lost after neuraminidase treatment was determined. Two gangliosides, GD1a and GT1b, were found to be capable of functioning as specific receptors for influenza virus. Both gangliosides restored completely the virus adsorption on erythrocytes. In contrast, none of the three gangliosides used did not restore parainfluenza virus adsorption. It is concluded that the nature of influenza and parainfluenza virus receptors is different.
D000327:Adsorption; D000818:Animals; D002460:Cell Line; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D005732:Gangliosides / Q000378:metabolism; D006168:Guinea Pigs; D009980:Influenza A virus / Q000378:metabolism*; D009439:Neuraminidase / Q000494:pharmacology; D009975:Orthomyxoviridae / Q000378:metabolism*; D010224:Parainfluenza Virus 3, Human / Q000378:metabolism*; D011991:Receptors, Virus / Q000187:drug effects / Q000378:metabolism*; D018108:Respirovirus / Q000378:metabolism*; D014776:Virus Cultivation
D005732:Gangliosides; D011991:Receptors, Virus; D009439:Neuraminidase
Raznaia priroda kletochnykh retseptorov dlia virusov grippa i paragrippa.