Gamma camera evaluation of the effects of degradable starch microspheres on arterial liver blood flow in the rat.
Degradable starch microspheres injected into an artery causes a temporary reduction of regional blood flow and improves the exposure of the organ to a drug injected simultaneously. The purpose of this study was to quantify this effect when microspheres are injected arterially into the liver of rats. As model substance radioactive pertechnetate ions (99TcmO4-) was used. The results were evaluated from external gamma camera measurements. The amounts of microspheres injected together with pertechnetate was 1.5-12 mg. When compared to injections of pertechnetate only, the integrated exposure of the liver to pertechnetate was increased by a factor of 1.4-2.4 when microspheres were added.
D000818:Animals; D001158:Arteries / Q000000981:diagnostic imaging / Q000502:physiology*; D008099:Liver / Q000000981:diagnostic imaging; D008102:Liver Circulation; D008297:Male; D008863:Microspheres; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013670:Sodium Pertechnetate Tc 99m; D013213:Starch / Q000494:pharmacology*
D013213:Starch; D013670:Sodium Pertechnetate Tc 99m