Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques.
In the neocortex of an aged (26-year-old) rhesus monkey, a small percentage of abnormal neurites within some senile plaques (defined by the presence of amyloid) were immunoreactive for glutamic acid decarboxylase. This suggests that gamma-aminobutyric acid-synthesizing neurons may contribute to plaque formation in the aged brain.
D000375:Aging; D000682:Amyloid / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000201:enzymology* / Q000502:physiology; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D008253:Macaca mulatta; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D000682:Amyloid; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase