The protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), inhibits muscarinic (M1) receptor-mediated inositol phosphate release and cyclic GMP formation in murine neuroblastoma cells (clone N1E-115).
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D002460:Cell Line; D006152:Cyclic GMP / Q000096:biosynthesis*; D007295:Inositol Phosphates / Q000378:metabolism*; D051379:Mice; D009447:Neuroblastoma; D010703:Phorbol Esters / Q000494:pharmacology; D010704:Phorbols / Q000494:pharmacology*; D011493:Protein Kinase C / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000187:drug effects*; D013403:Sugar Phosphates / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D007295:Inositol Phosphates; D010703:Phorbol Esters; D010704:Phorbols; D011976:Receptors, Muscarinic; D013403:Sugar Phosphates; C008876:phorbol-12,13-didecanoate; D002217:Carbachol; D011493:Protein Kinase C; D006152:Cyclic GMP; D013755:Tetradecanoylphorbol Acetate