Methylation and expression of the human thyroglobulin gene.
The DNA methylation pattern at the 5'end of the human thyroglobulin gene has been determined in different tissues. Out of the four HpaII/MspI sites (5'-CCGG-3') present in this region, three were found to be non-methylated in thyroid DNA, while full methylation was observed in liver, salivary gland and sperm DNA. This demethylation therefore correlates with expression of the thyroglobulin gene. However, all four sites were found to be non-methylated in placental DNA, regardless of the activity of the gene.
D001483:Base Sequence; D004247:DNA / Q000378:metabolism*; D004262:DNA Restriction Enzymes; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D008745:Methylation; D009693:Nucleic Acid Hybridization; D010920:Placenta / Q000378:metabolism; D012469:Salivary Glands / Q000378:metabolism; D013094:Spermatozoa / Q000378:metabolism; D013954:Thyroglobulin / Q000235:genetics*; D013961:Thyroid Gland / Q000378:metabolism
D004247:DNA; D013954:Thyroglobulin; D004262:DNA Restriction Enzymes