Stress induces an increased hexose uptake in cultured cells.
Temperature-sensitive mutants have revealed a region of the herpes simplex virus 1 genome that affects both the uptake of hexose and the synthesis of heat shock proteins. Other inducers of heat-shock proteins, namely heat shock itself and arsenite, likewise induce an increased uptake of hexose. The increased uptake, like that induced by insulin, is insensitive to the presence of actinomycin D or cycloheximide. It is concluded that an increased hexose uptake, reflecting an activation or relocation of existing hexose transport protein, is a general biochemical response of stressed cells.
D019325:3-O-Methylglucose; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001151:Arsenic / Q000494:pharmacology; D018053:Arsenites; D001693:Biological Transport, Active; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D006224:Cricetinae; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000096:biosynthesis; D006358:Hot Temperature; D007668:Kidney; D008647:Mesocricetus; D008757:Methylglucosides / Q000378:metabolism*; D008759:Methylglycosides / Q000378:metabolism*; D018139:Simplexvirus / Q000235:genetics / Q000502:physiology*; D013312:Stress, Physiological / Q000378:metabolism*
D000596:Amino Acids; D018053:Arsenites; D003837:Deoxy Sugars; D006360:Heat-Shock Proteins; D008757:Methylglucosides; D008759:Methylglycosides; D019325:3-O-Methylglucose; D003847:Deoxyglucose; C015001:arsenite; D001151:Arsenic