title: [NADH-vanadate-oxidoreductase in emotional-pain stress and its possible role in the regulation of Na+-K+-ATPase activity].
abstract: It is established that NADH-vanadate-oxidoreductase in brain and heart changes its activity depending on the period of the emotional pain stress (EPS) development. In early acute period of EPS (to 48 hours) NADH-vanadate-oxidoreductase is activated in the brain, while in the heart its activity lowers in comparison with normal animals. In the later period after EPS the stimulation of NADH-vanadate-oxidoreductase activity in the both organs in observed. This dynamics creates possibilities for different accumulation of such Na+,K+-ATPase inhibitor as vanadate (VO3-) in the heart and brain. An increase of pO2 of the blood, probably, influences the enhancement of the VO3- concentration in the blood and organs.
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D004789:Enzyme Activation; D009206:Myocardium / Q000201:enzymology; D009243:NAD / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013315:Stress, Psychological / Q000201:enzymology*; D013997:Time Factors; D014638:Vanadates; D014639:Vanadium / Q000378:metabolism*
chemical_list: D014639:Vanadium; D009243:NAD; D014638:Vanadates; D009247:NADH, NADPH Oxidoreductases; C047345:NADH-vanadate oxidoreductase; D000254:Sodium-Potassium-Exchanging ATPase
vernacular_title: NADH-vanadat-oksidoreduktaza pri émotsional'no-bolevom stresse i ee vozmozhnoe znachenie v reguliatsii aktivnosti Na+-K+-ATPazy.