Extrapituitary neuroendocrine melanoderma. Unique association of extensive melanoderma with macromelanosomes and extrapituitary secretion of a high molecular weight neuropeptide related to pro-opiomelanocortin.
A patient developed an Addison-like melanoderma over the past decade. An abnormal neuropeptide related to, but bigger than pro-opiomelanocortin was found in large amount in the serum. It has most likely a stimulative action upon melanogenesis with formation of macromelanosomes.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D004723:Endorphins / Q000097:blood; D005260:Female; D006729:Hormones, Ectopic / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008544:Melanocytes / Q000648:ultrastructure; D008548:Melanosis / Q000097:blood / Q000503:physiopathology*; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000503:physiopathology*; D011333:Pro-Opiomelanocortin; D001615:beta-Endorphin; D008083:beta-Lipotropin / Q000097:blood
D001786:Blood Glucose; D004723:Endorphins; D006729:Hormones, Ectopic; D001615:beta-Endorphin; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D008083:beta-Lipotropin; D006854:Hydrocortisone