Susceptibility of gram-negative bacteria to the synergistic bactericidal action of serum and polymyxin B nonapeptide.
Polymyxin B nonapeptide was able to sensitize Escherichia coli strains and strains of Salmonella typhimurium, Klebsiella spp., Enterobacter cloacae, Pseudomonas aeruginosa, and Haemophilus influenzae to the bactericidal action of fresh normal human serum. The degree of sensitization varied significantly within the strains. Strains of Proteus mirabilis, Neisseria gonorrhoeae, and N. meningitidis remained resistant.
D002442:Ceftazidime / Q000097:blood* / Q000494:pharmacology; D004754:Enterobacter / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D007709:Klebsiella / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000187:drug effects; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D009345:Neisseria meningitidis / Q000187:drug effects; D011112:Polymyxin B / Q000031:analogs & derivatives / Q000097:blood / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*; D011513:Proteus mirabilis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects
D011113:Polymyxins; C038934:polymyxin B nonapeptide; D002442:Ceftazidime; D011112:Polymyxin B