The outcome of pregnancy after chemotherapy for gestational trophoblastic disease.
Thirteen pregnancies in 11 women previously treated with cytotoxic chemotherapy for GTD were studied. There were 11 live full-term babies (84.6%), 2 blighted ova (15.4%), 1 placenta accreta (7.7%) and 1 fetal anomaly (7.7%). Unlike other series, 69% of the pregnancies occurred within 1 year after the termination of chemotherapy. The rate of successful pregnancy was not different from that reported by others. Prenatal elimination of abnormal embryos after conception rather than wastage of damaged oocyte before conception might explain this observed low incidence of abnormal birth in GTD patients treated with cytotoxic chemotherapy.
D000022:Abortion, Spontaneous; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000013:Congenital Abnormalities / Q000150:complications / Q000453:epidemiology; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D010921:Placenta Accreta / Q000150:complications / Q000453:epidemiology; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000188:drug therapy*; D014594:Uterine Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents