In vitro study of local solubility of uric acid stones with lithium carbonate.
The possibilities of local dissolution of uric acid calculi with Na hydrocarbonate, K carbonate and lithium carbonate were examined in vitro. The most promising results were obtained with lithium carbonate. The necessity for studies of the compound in laboratory animals before its use in humans is emphasized.
D001639:Bicarbonates / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008094:Lithium / Q000494:pharmacology*; D016651:Lithium Carbonate; D017680:Potassium Compounds; D012964:Sodium / Q000494:pharmacology; D017693:Sodium Bicarbonate; D012995:Solubility; D014527:Uric Acid / Q000378:metabolism*; D014545:Urinary Calculi / Q000378:metabolism*
D001639:Bicarbonates; D017680:Potassium Compounds; D014527:Uric Acid; D016651:Lithium Carbonate; D017693:Sodium Bicarbonate; D008094:Lithium; D012964:Sodium; C026329:potassium bicarbonate