[Participation of angiotensin II and acetylcholine in central mechanisms of alcoholic motivation in the rat].
Chemical sensitivity to acetylcholine (Ach) and angiotensin II (A-II) of the neurons from the perifornical area of the posterio-lateral hypothalamus was studied in rats after 30 days of alcoholization with 20% ethanol solution instead of water. The artificially formed alcohol motivation was accompanied by profound changes of the neuronal sensitivity to Ach and A-II. The latter changes were manifested by specific reorganization of time--interval patterns of neuronal activity. Changes of sensitivity to Ach were less obvious and involved prevalence of 30--40 msec intervals in the unit activity. These changes of chemical sensitivity to peptides and classical neurotransmitters may reflect profound changes in the system of intramembranous and intracellular cyclic nucleotides during alcoholization.
D000109:Acetylcholine; D000437:Alcoholism / Q000503:physiopathology*; D000804:Angiotensin II; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004594:Electrophysiology; D007031:Hypothalamus / Q000503:physiopathology*; D007034:Hypothalamus, Posterior / Q000503:physiopathology*; D007478:Iontophoresis; D008845:Microinjections; D051381:Rats; D011919:Rats, Inbred Strains; D012084:Renin-Angiotensin System
D000804:Angiotensin II; D000242:Cyclic AMP; D000109:Acetylcholine
Uchastie angiotenzina-II i atsetilkholina v tsentral'nykh mekhanizmakh alkogol'noĭ motivatsii u krys.