Inhibition of SV40 DNA replication in vitro by 1-N-acyl-3"-N-(trifluoroacetyl) kanamycin.
A new antiviral aminoglycoside antibiotic, 1-N-eicosanoyl-3''-N-(trifluoroacetyl) kanamycin, was found to inhibit SV40 DNA replication in vitro. Several other aminoglycoside antibiotics examined did not exhibit a significant inhibition of SV40 DNA replication. The elongation of the SV40 DNA strand was profoundly affected by this agent. The degree of inhibition was decreased by increasing the amount of DNA template, but not by increasing the amount of enzyme. The inhibition of SV40 DNA replication is attributed to the interaction between the agent and the DNA template.
D000583:Amikacin / Q000494:pharmacology; D000617:Aminoglycosides / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D016590:Aphidicolin; D004261:DNA Replication / Q000187:drug effects*; D004279:DNA, Viral / Q000096:biosynthesis*; D003843:Deoxycytidine Monophosphate / Q000378:metabolism; D003982:Dibekacin / Q000494:pharmacology / Q000031:analogs & derivatives; D004224:Diterpenes / Q000494:pharmacology; D000882:Haplorhini; D006921:Hygromycin B / Q000031:analogs & derivatives; D007612:Kanamycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D009268:Nalidixic Acid / Q000494:pharmacology; D009675:Novobiocin / Q000494:pharmacology; D013539:Simian virus 40 / Q000235:genetics*; D013053:Spectrophotometry; D013307:Streptomycin / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D004279:DNA, Viral; D004224:Diterpenes; D003843:Deoxycytidine Monophosphate; D009675:Novobiocin; D016590:Aphidicolin; D009268:Nalidixic Acid; D006921:Hygromycin B; D003982:Dibekacin; D007612:Kanamycin; D000583:Amikacin; C048726:1-eicosanoyl-3''-N-(trifluoroacetyl)kanamycin; C031986:arbekacin; C026091:destomycin A; D013307:Streptomycin