Oestrogen modulates dopamine-controlled behaviours in the male ferret.
Oestradiol (100 micrograms/kg) was administered to male ferrets on three successive days. Two and three days after the last oestradiol injection the effects of apomorphine (0.5 mg/kg) on stereotyped, predatory and scent marking behaviour were intensified. Thus, three days of oestradiol administration produced a supersensitive dopaminergic system two days after the last oestradiol injection. However, no initial antidopaminergic effect of oestradiol could be demonstrated one day after the last oestradiol injection.
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage; D001522:Behavior, Animal / Q000187:drug effects*; D004298:Dopamine / Q000502:physiology*; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology*; D005289:Ferrets; D008297:Male; D011235:Predatory Behavior / Q000187:drug effects; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D013731:Territoriality
D004958:Estradiol; D001058:Apomorphine; D004298:Dopamine