Calcium or magnesium concentration affects the severity of organophosphate-induced neuromuscular block.
When the rat diaphragm muscle was treated with düsopropyl fluorophosphate, an organophosphate inhibitor of acetylcholinesterase, a decrement in the compound action potential and in the force of contraction was observed. It was found that the decrement produced by 30 Hz nerve stimulation for 1 s could be reversed by lowering the calcium concentration or increasing the magnesium concentration.
D000818:Animals; D002118:Calcium / Q000008:administration & dosage*; D004347:Drug Interactions; D066298:In Vitro Techniques; D007531:Isoflurophate / Q000008:administration & dosage*; D008274:Magnesium / Q000008:administration & dosage*; D009469:Neuromuscular Junction / Q000187:drug effects*; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects*
D007531:Isoflurophate; D008274:Magnesium; D002118:Calcium