title: [Peptide inhibitors of a bacterial collagenase].
abstract: The properties of the cleavage site of collagen by collagenases remain discussed. The authors report their studies on the active site of the collagenase of a bacteria, achromobacter, based on two types of methods. The first type uses synthetic substrates, the second one enzymatic inhibitors. The results of both methods are reviewed. The inhibitors seem more sensitive than substrates to study the relation between structure and activity of the enzyme.
mesh_terms: D000421:Alcaligenes / Q000201:enzymology*; D001667:Binding, Competitive; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors*; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D013379:Substrate Specificity
chemical_list: D010455:Peptides; D003012:Microbial Collagenase
vernacular_title: Inhibiteurs peptidiques d'une collagénase bactérienne.