title: [Delayed neurotoxic action of a new fungicide aphos].
abstract: It has been established that administration of aphos to chickens within a wide dose range (3000-25 mg/kg) produces a retarded neurotoxic action that is manifested by the development of ataxia, pareses and paralyses; delay in the rate of the distribution of excitation via the peripheral axons, disorders of myoneural lability; degeneration of myelin fibers, focal granular degradation of myelin. The retarded neurotoxic action is not caused by impurities contained by the technical-grade preparation in view of the fact that such an action is also common to the chemically pure aphos.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004340:Drug Contamination; D004655:Emulsions; D005260:Female; D005659:Fungicides, Industrial / Q000506:poisoning / Q000633:toxicity*; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology; D062025:Organophosphate Poisoning; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010525:Peripheral Nerves / Q000187:drug effects*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D009435:Synaptic Transmission / Q000187:drug effects; D013997:Time Factors
chemical_list: D004655:Emulsions; D005659:Fungicides, Industrial; D009943:Organophosphorus Compounds; C034223:aphos
vernacular_title: Zamedlennoe neĭrotoksicheskoe deĭstvie novogo fungitsida afosa.