[Immunological status of hemophiliacs: study of blood T-lymphocyte populations, serum immunoglobulins, and the prevalence of anti-LAV antibodies].
Blood T-lymphocyte subsets and serum immunoglobulin levels were studied in a group of 52 haemophiliacs (44 patients with haemophilia A and 8 patients with haemophilia B). None of the patients had AIDS or belonged to any AIDS high-risk group. Patients were exclusively treated with clotting fractions obtained from healthy volunteers in metropolitan France. As compared to a group of 52 normal donors, haemophiliacs had increased numbers of suppressor lymphocytes, which resulted in depressed helper/suppressor (H/S) ratios, and increased levels of serum IgG and IgA. 21 haemophiliacs (40,3%) had a H/S ratio less than 1.4. Among patients with haemophilia A a higher mean IgG level was found in patients presenting lymphadenopathy. Decreased mean H/S ratio and increased mean serum IgG level were found in patients receiving more than 50 000 U of factor VIII during the 2 years preceding the study. No striking difference in mean serum IgG, IgA and IgM levels was found in patients with haemophilia A when H/S ratios were higher and lower than 1.4 respectively. As AIDS and immunological abnormalities among haemophiliacs probably share a common viral origin, this study emphasize the need to discourage blood donation from donors who belong to any AIDS high-risk group, and to screen sera from the blood donor population for antibodies to LAV/HTLV III.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D017977:Deltaretrovirus / Q000276:immunology*; D005169:Factor VIII / Q000008:administration & dosage / Q000502:physiology; D006467:Hemophilia A / Q000097:blood / Q000276:immunology*; D002836:Hemophilia B / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D008875:Middle Aged; D013601:T-Lymphocytes / Q000145:classification*
D000914:Antibodies, Viral; D007136:Immunoglobulins; D005169:Factor VIII
Etat immunologique des hémophiles: étude des populations T-lymphocytaires sanguines, des immunoglobulines sériques et de la prévalence des anticorps anti-LAV.