[Blockade of postsynaptic adrenergic alpha receptors--a new principle for inhibiting uterine contraction].
In analogy to beta 2 mimetic agents, also alpha 1 adrenoblockers should show an uterus-relaxing effect. Therefore, the tocolytic effect of prazosin, which is supposed to be the most potent alpha 1 blocking agent, was investigated in myometrial strips. Uterine activity was highly significantly (p less than 0.001) decreased by reduction of frequency and amplitude, but not by duration and area of spontaneous uterine contractions.
D046508:Culture Techniques; D005260:Female; D006801:Humans; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011224:Prazosin / Q000627:therapeutic use*; D011247:Pregnancy; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D014590:Uterine Contraction / Q000187:drug effects*
D011942:Receptors, Adrenergic, alpha; D011224:Prazosin
Blockade postsynaptischer alpha-Adrenorezeptoren--ein neues Prinzip zur Hemmung von Uteruskontraktionen.