History of the development of inhibitors of angiotensin I conversion.
The major steps in the initial development of angiotensin I conversion inhibitors are described, from the discovery of the Bothrops peptides (bradykinin potentiating factor) to the demonstration of the therapeutic potential. It is a history where chance, serendipity and clear scientific reasoning weaved together the work of several scientists. It is also a classical example of drug development for which the initial basic research was made at the university, but the useful product was achieved by industry.
D000803:Angiotensin I / Q000037:antagonists & inhibitors*; D000806:Angiotensin-Converting Enzyme Inhibitors; D000809:Angiotensins / Q000037:antagonists & inhibitors*; D000959:Antihypertensive Agents / Q000266:history*; D001711:Biotransformation; D001920:Bradykinin / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D008970:Molecular Weight
D000806:Angiotensin-Converting Enzyme Inhibitors; D000809:Angiotensins; D000959:Antihypertensive Agents; D000803:Angiotensin I; D001920:Bradykinin