title: Increase of serum angiotensin-converting enzyme level after exposure to cigarette smoke and nicotine infusion in dogs.
abstract: Smoking is known to have various effects on metabolic function as well as on the respiratory function in the lung. We report here that exposure to smoke causes a rapid elevation of the level of serum angiotensin-converting enzyme in dogs in vivo. In 7 dogs, the level of serum angiotensin-converting enzyme increased from a basal level of 11.0 +/- 5.0 to 13.9 +/- 4.0 U/ml after 60 min of exposure (mean +/- SD, p less than 0.01). A similar elevation of serum angiotensin-converting enzyme level was noted in dogs that received an intravenous administration of nicotine. The possible mechanism of the change is discussed.
mesh_terms: D000818:Animals; D004285:Dogs; D008168:Lung / Q000201:enzymology; D009538:Nicotine / Q000494:pharmacology*; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D010947:Plants, Toxic; D012906:Smoke; D013268:Stimulation, Chemical; D014026:Nicotiana
chemical_list: D012906:Smoke; D009538:Nicotine; D007703:Peptidyl-Dipeptidase A