Stimulation of glucose oxidation in rat submandibular gland cells in vitro by analogues of cyclic AMP.
Secretion from salivary glands, following autonomic stimulation, is energy-dependent. Rat submandibular gland cells, when treated in vitro with both alpha- and beta-adrenergic agonists, showed increased glucose oxidation. The effects of alpha-adrenergic agents on glucose metabolism can be mimicked by non-receptor mobilization of Ca2+. Analogues of cyclic AMP were capable of elevating glucose metabolism to nearly the same extent as beta-adrenergic agonists.
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D000242:Cyclic AMP / Q000031:analogs & derivatives* / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013363:Submandibular Gland / Q000378:metabolism*; D013997:Time Factors
D000001:Calcimycin; D000242:Cyclic AMP; D005947:Glucose; D007545:Isoproterenol; D004837:Epinephrine