title: MR imaging of the intervertebral disc: a quantitative study.
abstract: The T1 and T2 relaxation times and the proton density of the nucleus pulposus have been measured in 107 normal and 18 surgically proven degenerate intervertebral discs. Data from total saturation recovery and spin echo sequences have been utilised in a robust multi-point method and relaxation times and proton density calculated. The results show that both the T1 and T2 values of the normal nucleus pulposus decrease with age. There was no significant correlation between proton density and age in normal discs. At all ages there was a highly significant difference between the T1 values of normal and degenerate discs. With T2 a highly significant difference in the younger age groups reduced to no distinction in the seventh decade. The observed change in the T1 and T2 values of the nucleus is in agreement with the reduction of water content known to occur with age. Our results indicate that quantitative MR imaging may assist in the diagnosis of intervertebral disc degeneration.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D002648:Child; D006801:Humans; D007403:Intervertebral Disc / Q000000981:diagnostic imaging / Q000473:pathology*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation; D009192:Myelography; D011522:Protons; D013122:Spinal Diseases / Q000175:diagnosis; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D011522:Protons