Association of the pX gene product of human T-cell leukemia virus type-I with nucleus.
Human T-cell leukemia virus type I (HTLV-I) contains a unique gene pX coding for p40 chi, and this protein was suggested to activate the transcription from the LTR of HTLV. By a similar mechanism, this viral function might be involved in immortalization of T-cells and leukemogenesis in adult T-cell leukemia induced by HTLV-I. In this communication, a part of the p40 chi was found to be tightly associated with nuclei in infected cell lines by subcellular fractionation and immunofluorescence staining.
D002458:Cell Fractionation; D002460:Cell Line; D002467:Cell Nucleus / Q000032:analysis*; D017977:Deltaretrovirus / Q000235:genetics / Q000502:physiology; D005455:Fluorescent Antibody Technique; D005814:Genes, Viral; D006801:Humans; D012191:Retroviridae Proteins / Q000032:analysis*; D013601:T-Lymphocytes
D012191:Retroviridae Proteins