[Study of the beta-adrenoreceptive function of the erythrocyte membrane of the guinea pig using spectral luminescence analysis].
The binding of DSM fluorescent probe with erythrocyte membranes in conditions of the organism high and low adrenoreactivity was studied in guinea pig. The dependence of DSM binding on the level of adrenoreactivity was shown by probe luminescence in the range of 615 nm. Specific and unspecific types of the DSM bindings with erythrocyte membranes were revealed. In high adrenoreactivity, an increase of specific binding places (Nsp) and a decrease of specific binding constant (Ksp) were found whereas in low adrenoreactivity the Nsp decreased and the Ksp increased.
D000818:Animals; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005456:Fluorescent Dyes; D006145:Guanethidine / Q000494:pharmacology; D006168:Guinea Pigs; D011433:Propranolol / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
C032315:4-(4-dimethylaminostyryl)-1-methylpyridinium; D005456:Fluorescent Dyes; D011726:Pyridinium Compounds; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D006145:Guanethidine
Issledovanie beta-adrenoretseptivnoĭ funktsii membran éritrotsitov morskoĭ svinki s pomoshch'iu spektral'nogo liuminestsentnogo analiza.