title: Sensitivity of 115 strains of the genus Brucella to some antibiotics (cephalosporins, ureidopenicillins and aminoglycosides).
abstract: The Authors tested piperacillin, azlocillin, aztreonam, cefotaxime, ceftizoxime, ceftriaxone, cefotetan, moxalactam, gentamicin, sisomicin and dibekacin, on about 120 strains of the genus Brucella, using as control drugs tetracycline, streptomycin and rifampicin. Cefotaxime, ceftizoxime, gentamicin, and sisomicin exhibited antibrucella activity comparable to that of tetracycline and just a little superior to that of rifampicin. Among the aminoglycosides tested, gentamicin, sisomicin and dibekacin were, in decreasing order, more active than streptomycin. For all the other drugs tested there was a large variability among the brucella strains, with roughly a peak of activity on the strains which have a history of repeated in vitro passages.
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002002:Brucella / Q000187:drug effects*; D002511:Cephalosporins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins; D010397:Penicillanic Acid