title: [Alpha 2-adrenoreceptor regulation in the human body].
abstract: The affinity of platelet alpha-2-adrenoreceptors for adrenaline is decreased in vivo and in vitro exposure of platelets to catecholamines at physiological concentrations in normal subjects. The direction of these alterations is consistent with the direction of the desensitization phenomena observed in the intact platelet. Hypertensive subjects display an abnormality characterized by an inability to reduce the affinity of their platelet alpha-2-adrenoreceptors in response to increased circulating levels of catecholamines. The potential importance of this defect in the etiology and clinical manifestations of essential hypertension remains to be ascertained.
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001667:Binding, Competitive / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D004837:Epinephrine / Q000097:blood / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000097:blood; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D015016:Yohimbine / Q000494:pharmacology
chemical_list: D011942:Receptors, Adrenergic, alpha; D015016:Yohimbine; D000244:Adenosine Diphosphate; D009638:Norepinephrine; D004837:Epinephrine
vernacular_title: Reguliatsiia al'fa 2-adrenoretseptorov v organizme cheloveka.