Neonatal monosodium glutamate dosing alters the sleep-wake cycle of the mature rat.
Alterations of the sleep-wake cycle have been studied in male adult rats after neonatal administration of monosodium glutamate (MSG; 4 X 4 mg/g body wt.). Results indicated that MSG treatment caused: an almost complete disappearance of ACTH and alpha-MSH immunoreactive (IR) perikarya in the rostral part of the arcuate nucleus; an increase in total sleep duration with a more pronounced effect on paradoxical sleep. Regarding circadian rhythmicity there was a trend to a decomposition of the 24 h period into ultradian components (12 h, 8 h, 6 h harmonics). The participation of pro-opiomelanocortin peptides in sleep regulation is discussed.
D000204:Activity Cycles / Q000187:drug effects; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001111:Arcuate Nucleus of Hypothalamus / Q000378:metabolism; D002940:Circadian Rhythm / Q000187:drug effects; D005971:Glutamates / Q000494:pharmacology*; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism; D010507:Periodicity / Q000187:drug effects*; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects; D012970:Sodium Glutamate / Q000494:pharmacology*
D005971:Glutamates; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D012970:Sodium Glutamate