Preliminary characterization of a fast-growing strain of human hepatitis A virus.
A fast-growing strain of Human Hepatitis A (HHA) virus was selected by progressively shortening by the time between serial passages of the isolate in the simian cell line Frp/3. The virus so selected infected 90-95% of the cells in 7-10 days, and developed a strong cytopathic effect (CPE). The synthesis of HHA-specific antigens and the CPE were neutralized simultaneously by standard anti-HHA sera. This fast-growing strain has the characteristics of a picornavirus.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D004797:Enzyme-Linked Immunosorbent Assay; D006507:Hepatovirus / Q000235:genetics / Q000276:immunology / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D009500:Neutralization Tests; D012367:RNA, Viral / Q000032:analysis
D000956:Antigens, Viral; D012367:RNA, Viral