Oncogenes and a specific chromosomal abnormality associated with small-cell lung cancers.
Studies on oncogenes and a specific chromosomal abnormality involved in small-cell lung cancers are reviewed. Amplification and/or expression of one of the three myc family oncogenes (c-myc, N-myc, L-myc) were found in 21 of 31 small-cell lung cancers. However, oncogenes were not detected in DNAs of small-cell lung cancers by the NIH3T3 transfection assay. In addition, a specific deletion on the short arm of chromosome number 3 was often associated with small-cell lung cancers. These characteristics are quite different from those of non-small-cell lung cancers.
D018288:Carcinoma, Small Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D005784:Gene Amplification; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D009857:Oncogenes