Synaptogenesis in the neonatal preoptic area grafted into the aged brain.
The medial preoptic area (POA) of newborn female rats was transplanted into the third ventricle of young adult (2 months of age) and aged (27 months of age) female rats. The grafted POA tissues were examined ultrastructurally 2 months after transplantation. The mean numbers of axodendritic shaft and spine synapses in the POA transplants in both young adult and aged female rats were much greater than those in the medial POA of newborn female rats. These results suggest that the neuronal substrates in the medial POA grafts develop well in the brain of the aged female rats.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D005260:Female; D006085:Graft Survival; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D011301:Preoptic Area / Q000098:blood supply / Q000502:physiology / Q000637:transplantation*; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission; D013997:Time Factors