title: The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex.
abstract: Examination of the histocompatibility region of the nonobese diabetic (NOD) mouse with antibodies against class II glycoproteins (products of immune response genes of the major histocompatibility complex I-A and I-E), hybrid T-cell clones, and mixed-lymphocyte cultures and analysis of restriction fragment length polymorphisms indicate that the NOD mouse has a unique class II major histocompatibility complex with no expression of surface I-E, no messenger RNA for I-E alpha, and an I-A not recognized by any monoclonal antibodies or hybrid T-cell clones studied. In crosses of NOD mice with control C3H mice, the development of diabetes was dependent on homozygosity for the NOD mouse's unique major histocompatibility region.
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005808:Genes, Recessive; D008040:Genetic Linkage; D005838:Genotype; D006183:H-2 Antigens / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D007376:Interleukin-2 / Q000096:biosynthesis; D008285:Major Histocompatibility Complex; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics*; D013154:Spleen / Q000502:physiology
chemical_list: D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II; D007376:Interleukin-2; D004262:DNA Restriction Enzymes