title: gamma-Aminobutyric acid-dependent motility induced by avermectin B1a in the isolated intestine of the guinea pig.
abstract: In the isolated ileum of the guinea pig, neurally mediated rhythmic longitudinal mechanical activity was induced by avermectin, a macrolide anthelmintic that releases gamma-aminobutyric acid (GABA) and modulates the GABAA-receptor-ionophore complex. This avermectin-induced activity was dependent on GABA, being reduced or abolished by bicuculline, a GABAA-receptor antagonist, and by 3-mercaptopropionic acid which prevents neural GABA release. These results provide additional direct evidence that GABA is a functional neurotransmitter in the myenteric plexus of the guinea pig intestine, evidently involved in the regulation of intestinal motility.
mesh_terms: D015097:3-Mercaptopropionic Acid / Q000494:pharmacology; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007559:Ivermectin / Q000031:analogs & derivatives*; D007783:Lactones / Q000494:pharmacology*; D008297:Male; D009197:Myenteric Plexus / Q000502:physiology*; D011963:Receptors, GABA-A / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D007783:Lactones; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; C022120:avermectin B(1)a; D007559:Ivermectin; D015097:3-Mercaptopropionic Acid; D001640:Bicuculline