Understanding leukotrienes.
The leukotrienes of white cells are powerful pharmacological mediators that are implicated in many immunological reactions. The most powerful effects (bronchoconstriction and mucus secretion) are seen in asthma. The circulatory effects are local, except perhaps in endotoxin shock. Apart from corticosteroids, there are as yet no inhibitors in use in therapeutics.
D000818:Animals; D001249:Asthma / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors / Q000502:physiology; D008084:Lipoxygenase / Q000378:metabolism; D008168:Lung / Q000503:physiopathology; D008214:Lymphocytes / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000494:pharmacology; D013189:SRS-A / Q000037:antagonists & inhibitors / Q000502:physiology
D013189:SRS-A; D007975:Leukotriene B4; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases