title: Carbon-11 labeled dialkylketones: synthesis of 9-[11C]heptadecan-9-one.
abstract: 9-[11C]heptadecan-9-one was synthesized from di-n-octylthexylborane via cyanidation with K11CN. The rearrangement of the organoborane intermediate followed by alkaline oxidation produced the title compound in 55-60 min from the end of bombardment (EOB) in 50-70% overall yield. The reaction sequence is applicable for the synthesis of various dialkyl ketones.
mesh_terms: D001880:Boranes; D002250:Carbon Radioisotopes; D007553:Isotope Labeling; D007659:Ketones / Q000138:chemical synthesis*
chemical_list: D001880:Boranes; D002250:Carbon Radioisotopes; D007659:Ketones; C050509:9-heptadecanone