Imaging techniques for myocardial inflammation.
Dilated cardiomyopathy (DC) represents a heterogeneous group of disorders which results in morbidity and mortality in young individuals. Recent evidence suggests that a subset of these patients have histologic evidence of myocarditis which is potentially treatable with immunosuppression. The identification of myocardial inflammation may therefore lead to development of therapeutic regimens designed to treat the cause rather than the effect of the myocardial disease. Ultimately, this may result in improvement in the abysmal prognosis of DC. The currently accepted technique for identification of active myocardial inflammation is endomyocardial biopsy. This technique is not perfect, however, since pathologic standards for the diagnosis of myocarditis have not been established. Furthermore, focal inflammation may give rise to sampling error. The inflammation-avid radioisotope gallium-67 citrate has been used as an adjunct to biopsy improving the yield of myocarditis from 7 percent to 36 percent. Serial imaging correlates well to biopsy results. Future studies are designed to study the applicability of lymphocyte labelling techniques to myocardial inflammatory disease.
D000818:Animals; D001706:Biopsy; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000473:pathology; D011756:Diphosphates; D005710:Gallium Radioisotopes; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007249:Inflammation; D009205:Myocarditis / Q000000981:diagnostic imaging*; D009206:Myocardium / Q000473:pathology; D011817:Rabbits; D011877:Radionuclide Imaging; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate
D011756:Diphosphates; D005710:Gallium Radioisotopes; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium