The role of Pseudomonas species in patients treated with ampicillin and Sulbactam for gangrenous and perforated appendicitis.
A prospective, randomized, double-blinded comparison of Sulbactam and ampicillin and clindamycin and gentamicin is described. The combination of ampicillin and Sulbactam was not as effective in the management of perforated appendicitis and gangrenous appendicitis as was clindamycin and gentamicin. While both combinations of antibiotics had good anaerobic activity and failures were not associated with the recovery of Bacteroides fragilis group organisms, infectious complications were seen in patients from whom Pseudomonas were isolated. These pseudomonads were not nosocomially acquired and were found especially in patients with perforated appendicitis. We concluded that the combination of clindamycin and gentamicin, although less convenient to administer to the patient, remains the adjunctive antibiotic management of choice for perforated or gangrenous appendicitis. The epidemiologic factors of Pseudomonas species as a primary pathogen in peritonitis deserves further attention.
D000328:Adult; D000667:Ampicillin / Q000627:therapeutic use*; D001064:Appendicitis / Q000188:drug therapy* / Q000473:pathology; D002981:Clindamycin / Q000627:therapeutic use; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005734:Gangrene; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D007416:Intestinal Perforation / Q000188:drug therapy*; D008297:Male; D010397:Penicillanic Acid / Q000627:therapeutic use*; D010538:Peritonitis / Q000188:drug therapy; D011446:Prospective Studies; D011549:Pseudomonas / Q000187:drug effects*; D011552:Pseudomonas Infections / Q000188:drug therapy; D011897:Random Allocation; D012422:Rupture, Spontaneous; D013407:Sulbactam
D005839:Gentamicins; D002981:Clindamycin; D000667:Ampicillin; D010397:Penicillanic Acid; D013407:Sulbactam