title: Toxicity of parathyroid hormone in uremia.
abstract: The most significant complication of elevated parathyroid hormone (PTH) levels in uremia is the development of osteitis fibrosa cystica. The hormone also appears to play a role in soft-tissue and organ calcification, metabolic abnormalities (glucose, lipids), and electroencephalographic changes seen in uremic patients. Its role in the hematological abnormalities of uremia (anemia, bleeding) is controversial. A role for PTH in heart and skeletal muscle dysfunction in uremia has not been clearly established. Further studies are required to establish PTH as a "universal" toxin in uremia.
mesh_terms: D000740:Anemia / Q000209:etiology; D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology; D002648:Child; D004285:Dogs; D005947:Glucose / Q000378:metabolism; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology; D050356:Lipid Metabolism; D001523:Mental Disorders / Q000209:etiology; D009422:Nervous System Diseases / Q000209:etiology; D010002:Osteitis Fibrosa Cystica / Q000209:etiology; D010281:Parathyroid Hormone / Q000097:blood / Q000502:physiology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology; D018016:Receptors, Parathyroid Hormone; D013577:Syndrome; D014118:Toxins, Biological; D014511:Uremia / Q000150:complications / Q000503:physiopathology*
chemical_list: D010281:Parathyroid Hormone; D011956:Receptors, Cell Surface; D018016:Receptors, Parathyroid Hormone; D014118:Toxins, Biological; D005947:Glucose