Peptide hormone production in small cell lung carcinomas with particular reference to gastrin-releasing peptide.
Tissues of 50 small cell lung carcinomas were examined for production of 17 peptide hormones. Only when the concentration of a peptide detected in the tumor was 10 pmol or more per g wet weight, was the peptide considered to be produced by the tumor. The frequency of production of at least one of these peptide hormones was 84%, and that of two or more hormones was 50%. These results indicate that peptide hormone production is a very common phenomenon in small cell lung carcinoma. Of the peptide hormones examined, gastrin-releasing peptide is produced with the highest frequency, suggesting that this peptide could play an important role in small cell lung carcinoma.
D000328:Adult; D000595:Amino Acid Sequence; D001839:Bombesin / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000378:metabolism*; D019886:Gastrin-Releasing Peptide; D006728:Hormones / Q000032:analysis*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D010455:Peptides / Q000032:analysis*; D011863:Radioimmunoassay
D006728:Hormones; D010455:Peptides; D019886:Gastrin-Releasing Peptide; D001839:Bombesin