Activation of a D-form of rabbit muscle glycogen synthase by Ca2+-activated protease.
Glycogen synthase isolated from rabbit skeletal muscle as a D-form (synthase D2) is activated by a rat liver cytosolic protein differing from any of the known protein phosphatases (D2 activase). Although reversible by phosphorylation by cyclic AMP-dependent protein kinase, the activation is a result of limited proteolysis by D2 activase, which has been identified as the Ca2+-activated protease.
D000818:Animals; D002154:Calpain / Q000378:metabolism*; D003600:Cytosol / Q000201:enzymology; D004789:Enzyme Activation; D006006:Glycogen Synthase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D009132:Muscles / Q000201:enzymology*; D010766:Phosphorylation; D011817:Rabbits; D051381:Rats
D006006:Glycogen Synthase; D002154:Calpain