Idiopathic Parkinson's disease and the Lewy body disorders.
A common clinical manifestation of idiopathic Lewy body disease is levodopa responsive idiopathic Parkinson's disease. Infrequently features such as dementia or autonomic failure predominate. The Lewy body is also reported; as an incidental finding in 7-10% of normal individuals mostly over the age of 60 as an incidental sporadic finding in Parkinson's syndrome from other causes, mostly over the age of sixty; in an additional group of degenerative disorders at a younger age, some with familial inheritance. The incidental finding of Lewy bodies can precede clinical Parkinson's disease. It is though they do not occur as an age-related feature, although this cannot be stated with certainty. Current evidence suggests that about 10% of the population may possess the pathological substratum for idiopathic Parkinson's disease.
D000375:Aging; D001260:Ataxia Telangiectasia / Q000473:pathology; D001342:Autonomic Nervous System Diseases / Q000473:pathology; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000473:pathology; D002524:Cerebellar Ataxia / Q000473:pathology; D003342:Corpus Striatum / Q000473:pathology; D003704:Dementia / Q000473:pathology; D006141:Guam; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology*; D008875:Middle Aged; D009422:Nervous System Diseases / Q000473:pathology*; D009468:Neuromuscular Diseases / Q000473:pathology; D009847:Olivary Nucleus; D009886:Ophthalmoplegia / Q000473:pathology; D006211:Pantothenate Kinase-Associated Neurodegeneration / Q000473:pathology; D010300:Parkinson Disease / Q000473:pathology*; D010301:Parkinson Disease, Postencephalitic / Q000473:pathology; D011149:Pons; D013378:Substantia Nigra; D013577:Syndrome