[Enkephalin and cyclic nucleotide content in the brain structures of rats at different stages of the formation and development of alcoholic dependence].
Rats with increased alcohol motivation have been found to have a rise in enkephalin levels in limbic cortex and a decrease in met-enkephalin levels in the brain basal ganglia. Reduction of met-enkephalin to leu-enkephalin ratio in basal ganglia, limbic cortex and hypothalamus may serve as an index of increased inclination to ethanol in these animals. Alcohol dependence is characterized by reduced cAMP content in the majority of brain structures studied, sharply decreased met-enkephalin levels in limbic cortex and hypothalamus, and diminished cAMP and cGMP content in hypothalamus. In the third stage of experimental alcoholism the partial normalization of met-enkephalin and cAMP levels is observed in brain structures, with cGMP content increased in hypothalamus and considerably reduced in basal ganglia.
D000437:Alcoholism / Q000209:etiology* / Q000378:metabolism; D000818:Animals; D001479:Basal Ganglia / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004745:Enkephalins / Q000378:metabolism*; D005260:Female; D007031:Hypothalamus / Q000378:metabolism; D008032:Limbic System / Q000378:metabolism; D008297:Male; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D051381:Rats
D004745:Enkephalins; D009712:Nucleotides, Cyclic; D000242:Cyclic AMP; D006152:Cyclic GMP
Soderzhanie énkefalinov i tsiklicheskikh nukleotidov v strukturakh mozga krys v razlichnye stadii formirovaniia i razvitiia alkogol'noĭ zavisimosti.