Synthesis of nitrogen-13 labeled alkylamines via amination of organoboranes.
Organoboranes react with nitrogen-13 labeled ammonia to produce alkylamines in moderate yield. When 13N labeled ammonia was bubbled into a tetrahydrofuran solution containing 0.5M tridecylborane, 1-[13N]aminodecane was formed in 25-30 min from the end of bombardment (EOB) in 40-60% overall yield. 1-[13N]aminooctane and 1-[13N]aminohexane were also synthesized from appropriate organoboranes in similar yield.
D000586:Amination; D000588:Amines / Q000138:chemical synthesis*; D001880:Boranes; D007553:Isotope Labeling; D009590:Nitrogen Radioisotopes
D000588:Amines; D001880:Boranes; D009590:Nitrogen Radioisotopes