[Effect of polysaccharides on the cyclic nucleotide content and phosphodiesterase activity in the organs of mice with Lewis lung carcinoma].
Prodigiozan and zymosan were shown to have different effects both on the intracellular content of cyclic nucleotides and pulmonary metastases formation in mice with Lewis' carcinoma. The authors believe that determination of cyclic nucleotide ratio in immunocompetent organs (thymus and spleen) may be used as an additional criterion for identification of new antitumour immunomodulators.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000378:metabolism* / Q000556:secondary; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D011354:Prodigiozan / Q000494:pharmacology*; D013154:Spleen / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism; D015054:Zymosan / Q000494:pharmacology*
D011135:Polysaccharides, Bacterial; D015054:Zymosan; D011354:Prodigiozan; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D006152:Cyclic GMP
Vliianie nekotorykh polisakharidov na soderzhanie tsiklicheskikh nukleotidov i aktivnost' fosfodiésterazy v organakh mysheĭ s kartsinomoĭ legkikh L'iuis.