Increased neuropeptide Y (NPY) receptor binding in hippocampus and cortex of spontaneous hypertensive (SH) rats compared to normotensive (WKY) rats.
Specific 125I-NPY binding in various brain regions of spontaneous hypertensive (SH) rats and age-matched normotensive (WKY) rats was compared. SH rats exhibited significantly greater 125I-NPY binding than WKY rats in the hippocampus (43%) and cortex (18%), but not hypothalamus, midbrain, striatum or pons-medulla. Scatchard analysis indicated that the increased 125I-NPY binding in the hippocampus of SH rats represents a greater number of NPY binding sites.
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism; D008636:Mesencephalon / Q000378:metabolism; D011149:Pons / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017476:Receptors, Neuropeptide Y
D011956:Receptors, Cell Surface; D017476:Receptors, Neuropeptide Y