Time-related asymmetric changes of brain microvessel beta-adrenergic receptors in the two hemispheres after carotid occlusion.
The effect of short term and long term ischemia induced by right carotid occlusion was studied on beta-adrenergic receptor function in rat cerebral microvessels. The results show a different time-dependent responsiveness of the two hemispheres to ischemia, with a pronounced and more persistent decrease in the number of capillary beta-receptors in the left side of the brain. The data suggest the existence of asymmetries in the control of brain microvasculature which may mediate the different time-course of beta-receptor changes in response to ischemia.
D000818:Animals; D001665:Binding Sites; D002196:Capillaries / Q000378:metabolism; D002340:Carotid Artery Diseases / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D020120:Iodocyanopindolol; D002546:Ischemic Attack, Transient / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008833:Microcirculation; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013997:Time Factors
D011943:Receptors, Adrenergic, beta; D020120:Iodocyanopindolol; D010869:Pindolol