[Enhanced transformation of human lymphocytes by Chinese herbs].
The enhancing effect of extracts from some Chinese herbs on transformation of lymphocytes by Epstein-Barr (EB) virus was tested in soft agar system. Daphne genkwa, Wikstroemia chamaedaphne, Wikstroemia indica, Stellera chamaejasme and Sparganium stoloniferum were found to activate early antigen (EA) of EB virus in Raji cells and also enhance transformation of lymphocytes by EB virus. But some other herbs, such as Abrus cantoniensis and Bulbophyllum inconspicuum were not able to activate EA, hence, no enhancing effect on transformation. The significance of these herbs in the enhancement of lymphocytes by EB virus and their relation to the development of nasopharyngeal carcinoma and other malignant diseases are discussed.
D000956:Antigens, Viral / Q000276:immunology; D002273:Carcinogens; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal
D000956:Antigens, Viral; D002273:Carcinogens; C033305:Epstein-Barr virus early antigen; D010936:Plant Extracts