[Participation of the endogenous opioid system in the formation of the body's response to stress].
Autonomic responses to acute stressors in unanesthetized, chair-restrained baboons and macacas include elevations in heart rate, blood pressure and respiratory rate. Naloxone, in a dose of 1.0 mg/kg intravenously, as well as morphine (1.0 mg/kg) suppresses autonomic alterations produced by the introduction of conditioned and unconditioned stimuli. When given in a dose of 0.1 mg/kg, naloxone, on the contrary, facilitates autonomic responses. The autonomic changes induced by electrical stimulation of the medial hypothalamus and nucleus tractus solitarius are influenced by naloxone--in both doses--and by morphine in the opposite manner. These data, as well as those derived from experiments on the effects of micro-injections of naloxone and morphine into the medial hypothalamus and nucleus tractus solitarius suggest that the endogenous opioid system is necessary to display complete autonomic response pattern in monkeys. A hypothesis is proposed to the effect that endogenous opioid system is important for establishing a precise correspondence between the body's potentialities and behavior, and environmental demands.
D000818:Animals; D001794:Blood Pressure; D004597:Electroshock; D004745:Enkephalins / Q000502:physiology*; D007031:Hypothalamus / Q000503:physiopathology; D008253:Macaca mulatta; D008526:Medulla Oblongata / Q000503:physiopathology; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010215:Papio; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*
D004745:Enkephalins; D011957:Receptors, Opioid; D009270:Naloxone; D009020:Morphine
Uchastie endogennoĭ opioidnoĭ sistemy v formirovanii otvetnoĭ reaktsii organizma na stressovye vozdeĭstviia.