Polymyxin B nonapeptide inhibits mating in Saccharomyces cerevisiae.
Polymyxin B nonapeptide enhanced susceptibility of yeast cells to various hydrophobic antibiotics and to mating pheromones. At much lower concentrations, the nonapeptide severely inhibited mating. The inhibition was caused by interference with sexual agglutination.
D000371:Agglutination / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004171:Diploidy; D006238:Haploidy; D000072235:Mating Factor; D010455:Peptides / Q000494:pharmacology; D011112:Polymyxin B / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics / Q000502:physiology
D000900:Anti-Bacterial Agents; D010455:Peptides; D011113:Polymyxins; D000072235:Mating Factor; C038934:polymyxin B nonapeptide; D011112:Polymyxin B