Stimulation by dopamine of protein phosphorylation in rat striatal slices.
Incubation of rat striatal slices with dopamine enhanced the phosphorylation of two proteins with mol. wts. of 64,000 and 43,000. Although dopamine did increase cAMP levels in striatal slices, the addition of cAMP to striatal slices did not mimic the effects of dopamine on protein phosphorylation. The present results suggest that cAMP-independent protein kinases may mediate some of the effects of dopamine within the corpus striatum.
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D000242:Cyclic AMP / Q000032:analysis; D004298:Dopamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013570:Synaptic Membranes / Q000378:metabolism
D009419:Nerve Tissue Proteins; D000242:Cyclic AMP; D011494:Protein Kinases; D004298:Dopamine