[Effect of adrenocorticotropic hormone on the secretory activity of the gonads and adrenals of male hamadryas baboons].
The time course of the secretion of steroid hormones to the adrenal and seminal veins following administration of synthetic ACTH was studied in experiments on mature male hamadryas baboons. Testosterone, 5 alpha-dihydrotestosterone, androstendion, 17-oxyprogesterone and 17-oxypregnenolone levels in the venous blood were determined by means of radioimmunoassays with preliminary chromatographic isolation of steroids on cellite. The rate of hormone secretion by the adrenal and seminal glands was calculated by the gradient of the hormone concentration in the peripheral blood and in the blood outflowing from the steroid secreting glands. Sharp activation of the seminal secretion of testosterone, 5 alpha-dihydrotestosterone, androstendion and 17-oxyprogesterone was recorded 10-30 min after ACTH administration. The time course of testosterone secretion by the testes in ACTH administration showed correlation with changes in the hormone concentration in the peripheral blood. The data obtained were indicative of the seminal origin of a short-term rise of testosterone concentration in male hamadryas baboons in the initial period of ACTH action. A possible mechanism of the ACTH effect on the biosynthesis of steroids in the testes was discussed.
D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000728:Androgens / Q000097:blood / Q000378:metabolism; D000818:Animals; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism; D008297:Male; D010215:Papio / Q000502:physiology*; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D000728:Androgens; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
Vliianie adrenokortikotropnogo gormona na sekretornuiu aktivnost' polovykh i nadpochechnykh zhelez samtsov pavianov gamadrilov.