title: Effects of some fatty acids on the serotonin N-acetyltransferase activity in cultured chick pineal glands.
abstract: Low concentrations of arachidonate, oleate, or palmitate significantly affected the cycle of NAT activity of cultured chick pineal glands in different ways. The effects observed were altered by change of the lighting conditions of culture. Effects of arachidonate were also shown to be altered by change of the serum component of the culture medium. Effects of premature exposure to light of glands cultured under diurnal conditions of illumination were changed markedly by substitution of the serum component of the medium or a supplement of ionophore A23187 and less markedly by supplements of fatty acids.
mesh_terms: D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001191:Arylamine N-Acetyltransferase / Q000378:metabolism*; D000001:Calcimycin / Q000494:pharmacology; D002645:Chickens; D006152:Cyclic GMP / Q000032:analysis; D005227:Fatty Acids / Q000097:blood / Q000494:pharmacology*; D008027:Light; D009924:Organ Culture Techniques; D010870:Pineal Gland / Q000201:enzymology*; D011485:Protein Binding
chemical_list: D001095:Arachidonic Acids; D005227:Fatty Acids; D016718:Arachidonic Acid; D000001:Calcimycin; D000123:Acetyltransferases; C048323:phenetidine N-acetyltransferase; D001191:Arylamine N-Acetyltransferase; D006152:Cyclic GMP