Local and systemic effects of orally applied sodium salts.
This study determines whether the oral application of a baking soda-3% hydrogen peroxide dentifrice and a nearly saturated sodium chloride mouthwash, as a home care method for treating periodontal disease, creates a sodium burden for human subjects. The dietary intake and urinary excretion of sodium and potassium were monitored in participating subjects. Urinary sodium did not increase in subjects using the method. Desquamative gingival lesions, however, were seen in all treated subjects. Further study is needed to determine safe salt concentrations for this home care regimen.
D000328:Adult; D001639:Bicarbonates / Q000494:pharmacology*; D005260:Female; D005504:Food Analysis; D005881:Gingiva / Q000187:drug effects; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000187:drug effects*; D010512:Periodontal Index; D012964:Sodium / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology* / Q000652:urine; D017693:Sodium Bicarbonate; D012965:Sodium Chloride / Q000494:pharmacology*; D013997:Time Factors
D001639:Bicarbonates; D012965:Sodium Chloride; D017693:Sodium Bicarbonate; D012964:Sodium; D006861:Hydrogen Peroxide