Effect of cupric ions on the permeability of erythrocyte membrane to non-electrolyte spin labels.
The addition of cupric ions caused decreased permeability to hydrophilic molecules and increased permeability to hydrophobic molecules. These results suggest that TEMPOL penetrates the erythrocyte in a different way than TEMPO. Penetration of TEMPOL is controlled by-SH groups, while TEMPO probably diffuses through the lipid bilayer. Cupric ions increase the permeability of erythrocyte membranes to both non-electrolytes in vivo.
D000818:Animals; D002347:Carps; D002463:Cell Membrane Permeability / Q000187:drug effects*; D003300:Copper / Q000494:pharmacology*; D019327:Copper Sulfate; D003497:Cyclic N-Oxides; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D013113:Spin Labels
D003497:Cyclic N-Oxides; D013113:Spin Labels; D003300:Copper; D019327:Copper Sulfate; C001803:tempol; C003959:TEMPO