Immunogenicity and antigenicity of infectious bursal disease virus serotypes I and II in chickens.
Chickens were inoculated with infectious bursal disease virus serotype I or serotype II to determine if their immune system can distinguish between the two serotypes. Chickens had neutralizing antibodies to only serotype I viruses following exposure to serotype I viruses, and chickens had antibodies to only serotype II viruses following exposure to serotype II viruses. No cross-reactions were observed between antisera prepared to each of these two serotypes using a cross-virus-neutralization assay. Signs of disease were detected only in birds exposed to a virulent serotype I isolate. Chicks exposed to the serotype II viruses were not protected from challenge with a virulent serotype I isolate. In one experiment, antibodies to a serotype II isolate, which were detected before challenge, did not protect chicks from challenge with a virulent serotype I isolate.
D000818:Animals; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral / Q000032:analysis; D002645:Chickens; D003429:Cross Reactions; D007243:Infectious bursal disease virus / Q000145:classification / Q000276:immunology*; D012087:Reoviridae / Q000276:immunology*; D012088:Reoviridae Infections / Q000276:immunology*; D012703:Serotyping; D014612:Vaccines
D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D014612:Vaccines