Platelet-activating factor-binding protein in human serum.
The occurrence of a kind of protein (PBP) with stronger PAF-binding ability than albumin was shown in human serum. The molecular weight of PBP was approximately 160K to 180K. PBP seemed to be a pentamer composed of five 32K subunits. PAF bound to PBP revealed platelet aggregation and was resistant to acetyl-hydrolase. PAF synthesized in neutrophils stimulated with the ionophore A23187 was released by PBP from cells.
D000818:Animals; D006801:Humans; D008970:Molecular Weight; D010972:Platelet Activating Factor / Q000378:metabolism*; D010974:Platelet Aggregation; D010980:Platelet Membrane Glycoproteins; D011817:Rabbits; D011956:Receptors, Cell Surface / Q000302:isolation & purification / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled
D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor