[Modification by mesoporphyrin-IX derivatives of Chinese hamster cell damage induced by high energy helium ions and protons].
The damaging effect of high-energy helium ions (4 GeV), protons (9 GeV), and standard radiation was different as studied on Chinese hamster cell cultures (clone 431). A possibility of increasing the survival of cells by the pre- and post-irradiation treatment with a mesoporphyrin-IX derivative was demonstrated. It is suggested that the radioprotective effect of the modifier is associated with the decreased level of aberrant mitoses.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D005720:Gamma Rays; D006371:Helium; D008652:Mesoporphyrins / Q000494:pharmacology*; D011166:Porphyrins / Q000494:pharmacology*; D011522:Protons; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D012062:Relative Biological Effectiveness
D008652:Mesoporphyrins; D011166:Porphyrins; D011522:Protons; D011837:Radiation-Protective Agents; D006371:Helium; C031468:mesoporphyrin IX
Modifikatsiia proizvodnym mezoporfirina-IX porazheniĭ kletok kitaĭskogo khomiachka vysokoénergeticheskimi ionami geliia i protonami.