Physiological doses of estradiol can increase lingual dyskinesia and cerebrospinal fluid homovanillic acid in monkeys.
In 4 ovariectomized monkeys bearing a dopamine-sensitive lingual dyskinesia due to a previous mid-brain lesion, 30 ng of 17 beta-estradiol injected subcutaneously, caused a 4-fold increase in the dyskinesia in the hour following the injection. In a separate experiment done on 7 anesthetized monkeys, the same dose of estradiol caused a significant increase of homovanillic acid in the cerebrospinal fluid obtained by cisternal puncture. The above findings suggest that very small doses of estradiol in the physiological range can increase dopaminergic transmission in the striatum via increased release.
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects; D004298:Dopamine / Q000502:physiology; D004409:Dyskinesia, Drug-Induced / Q000134:cerebrospinal fluid / Q000209:etiology*; D004958:Estradiol / Q000633:toxicity*; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D008252:Macaca fascicularis; D009435:Synaptic Transmission / Q000187:drug effects; D014060:Tongue Diseases / Q000139:chemically induced
D004958:Estradiol; D004298:Dopamine; D006719:Homovanillic Acid