title: Projections from brainstem nuclei to the nucleus paragigantocellularis lateralis in the cat.
abstract: Afferent projections from the pons and medulla to the nucleus paragigantocellularis lateralis (PGL) have been mapped in the cat using retrograde transport of horseradish peroxidase (HRP). In the caudal medulla, the major sources of afferents were the medial and lateral divisions of the solitary nuclei complex and the contralateral trigeminal nucleus caudalis. Labelled cells were also present in the dorsal column nuclei, nucleus intercalatus and praepositus hypoglossi but this may have been due to uptake of HRP into fibres of passage. In the dorsolateral medulla and pons, neurones in the vestibular complex and in the parabrachial nucleus were labelled bilaterally. Nucleus raphe magnus and raphe obscurus were both found to send projections to the PGL and labelled cells were also present throughout the pontine and medullary reticular nuclei as well as in PGL on the side opposite to the injection of HRP. These findings are discussed in relation to the role of the PGL in cardiovascular regulation and in the control of pain.
mesh_terms: D000818:Animals; D001931:Brain Mapping; D001933:Brain Stem / Q000502:physiology*; D002415:Cats; D006735:Horseradish Peroxidase; D008526:Medulla Oblongata / Q000502:physiology*; D011149:Pons / Q000502:physiology; D009435:Synaptic Transmission
chemical_list: D006735:Horseradish Peroxidase