title: The modulation of transmitter release in motor nerve endings varies with the type of muscle fiber innervated.
abstract: Electrophysiological studies of synaptic transmission in mammalian muscles revealed substantial differences between neuromuscular synapses associated with fast versus slow-twitch motor units. Synapses of fast units exhibited much higher tetanic and post-tetanic potentiation of neurotransmitter release than those of slow units. On the other hand, the tetanic potentiation of slow units increased faster as a function of the frequency of activation than that of fast units. These differences suggest a possible specialization of neuromuscular synapses with the type of motor units they are associated with.
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D005260:Female; D009119:Muscle Contraction; D009469:Neuromuscular Junction / Q000502:physiology*; D009928:Organ Specificity; D051381:Rats; D009435:Synaptic Transmission; D013997:Time Factors
chemical_list: D000109:Acetylcholine