[Effect of dimetpramid and metoclopramide on the rate of catecholamine turnover in the subcortical-stem structures of the rat brain].
Dimetpramide, a new antiemetic drug (manufactured in the USSR) from the group of substituted benzamides, produced, due to blockade of catecholaminergic receptors, an increase in dopamine and noradrenaline turnover rates in the subcortical-brainstem regions responsible for the behavioural activity when administered at considerably higher doses than those of metoclopramide, a conventional drug of similar type. It is suggested that the probability of the occurrence of undesirable side effects of dimetpramide in clinical practice (extrapyramidal and sedative effects) would be much less than with metoclopramide.
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D001933:Brain Stem / Q000187:drug effects* / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D006719:Homovanillic Acid / Q000378:metabolism; D008032:Limbic System / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000378:metabolism; D017983:Receptors, Catecholamine
D000932:Antiemetics; D001549:Benzamides; D002395:Catecholamines; D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine; C037141:dimetpramid; D008787:Metoclopramide; D006719:Homovanillic Acid
Vliianie dimetpramida i metoklopramida na skorost' oborota katekholaminov v podkorkovo-stvolovykh strukturakh golovnogo mozga krys.