High enkephalyl peptide degradation, due to angiotensin-converting enzyme-like activity in human CSF.
The metabolism of enkephalin peptides was studied in human cerebrospinal fluid. The degradation rates of (Leu)-enkephalin and (Leu)-enkephalin-Arg6 were compared and the latter was degraded at a 10-fold higher rate. The major enzyme activity was investigated by Mr determination and inhibition experiments, showing marked similarity with angiotensin-converting enzyme.
D002851:Chromatography, High Pressure Liquid; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000378:metabolism; D004745:Enkephalins / Q000134:cerebrospinal fluid*; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*
D004745:Enkephalins; D004743:Enkephalin, Leucine; C026768:enkephalin-Leu, Arg(6)-; D007703:Peptidyl-Dipeptidase A