[Study of the interaction of proflavine and isomeric diribonucleoside monophosphates CpG and GpC by proton magnetic resonance].
A comparative study of the interaction of proflavine with isomeric diribonucleoside monophosphates CpG and GpC has been made by the method of 1H NMR (270 MHz). A method of calculation of the parameters of complex formation from the concentration dependences of proton chemical shifts of the dye has been proposed. The equilibrium constants of 1:1 and 1:2 complexes association of these molecules and the most probable structures of the complexes have been determined.
D000166:Acridines / Q000032:analysis*; D003562:Cytidine / Q000031:analogs & derivatives* / Q000032:analysis; D003568:Cytidine Monophosphate / Q000031:analogs & derivatives / Q000032:analysis*; D003597:Cytosine Nucleotides / Q000032:analysis*; D015226:Dinucleoside Phosphates; D006150:Guanine Nucleotides / Q000032:analysis*; D006151:Guanosine / Q000031:analogs & derivatives* / Q000032:analysis; D006157:Guanosine Monophosphate / Q000031:analogs & derivatives / Q000032:analysis*; D007536:Isomerism; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D011370:Proflavine / Q000032:analysis*
D000166:Acridines; D003562:Cytidine; D003568:Cytidine Monophosphate; D003597:Cytosine Nucleotides; D015226:Dinucleoside Phosphates; D006150:Guanine Nucleotides; D006151:Guanosine; D006157:Guanosine Monophosphate; D011370:Proflavine; C015772:CpG dinucleotide; C004804:guanylyl-(3',5')-cytidine
Issledovanie vzaimodeĭstviia proflavina s izomernymi diribonukleozidmonofosfatami CpG i GpC metodom protonnogo magnitnogo rezonansa.