[Nonuniform effect of prolonged haloperidol administration on the GABA(A) and benzodiazepine receptors in different parts of the brain].
The experiments on male mice and rats have revealed reversed behavioral effects of muscimol and Ro 15-1788 after 15 days of haloperidol (0.25 mg/kg, twice daily) treatment. Muscimol (0.75 mg/kg), which depressed motor activity in saline-pretreated mice, stimulated it after discontinuation of long-term haloperidol administration. Ro 15-1788 stimulating effect in saline-pretreated rats gave way to sedative effect following haloperidol withdrawal. Simultaneously, the number of 3H-muscimol and 3H-flunitrazepam binding sites was decreased in forebrain, but increased in hindbrain. It was suggested that GABAA and benzodiazepine receptors in forebrain and hindbrain play opposite (inhibiting and stimulating, respectively) functional roles in the regulation of behaviour.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001570:Benzodiazepinones / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D005442:Flumazenil; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects*; D013997:Time Factors
D001570:Benzodiazepinones; D011963:Receptors, GABA-A; D009118:Muscimol; D005442:Flumazenil; D006220:Haloperidol
Neodinakovoe vliianie dlitel'nogo vvedeniia galoperidola na GAMK(A)- i benzodiazepinovye retseptory v raznykh otdelakh mozga.