title: Simple quantitative radioiodination of (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) by exchange labelling.
abstract: The synthesis of [125I]-(E)-5-(2-iodovinyl)-2'-deoxyuridine [( 125I]IVDU) by a halogen isotope exchange reaction has been monitored in various reaction conditions. Quantitative incorporation of radioiodine into IVDU was obtained within 20 min by a simple and safe method that is suitable for application in any nuclear medicine laboratory. The radiolabelled antiviral agent can be used without further purification.
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis*; D004660:Encephalitis / Q000000981:diagnostic imaging; D006561:Herpes Simplex / Q000000981:diagnostic imaging; D006801:Humans; D007065:Idoxuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D007457:Iodine Radioisotopes; D011854:Radiochemistry; D011877:Radionuclide Imaging
chemical_list: D000998:Antiviral Agents; D007457:Iodine Radioisotopes; C030360:5-(2-iodovinyl)-2'-deoxyuridine; D007065:Idoxuridine