[Behavioral and neurochemical changes in pups prenatally treated with methamphetamine].
Changes in behavior and central neurotransmitters were examined in pups prenatally treated with methamphetamine (MAP). Compared with the control pups, the following results were obtained in MAP pups : 1) No change was found in the development of the circadian rhythm of spontaneous locomotor activity; 2) Spontaneous locomotor activity was decreased, while vertical activity was increased significantly in the postnatal period from the 24th to 27th days; 3) No sensitization to the test dose of MAP was found regardless of the prenatal repeated MAP treatment; 4) Dopamine concentration and the number of specific 3H-spiperone binding sites decreased in the frontal cortex. These findings indicate that prenatal treatment with MAP does not produce a lasting sensitization to MAP, whereas it does produce changes in behavior coupled with a neurochemical change in the frontal cortex.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects*; D002395:Catecholamines / Q000032:analysis; D002940:Circadian Rhythm / Q000187:drug effects; D003342:Corpus Striatum / Q000032:analysis; D005260:Female; D005625:Frontal Lobe / Q000032:analysis; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D017981:Receptors, Neurotransmitter / Q000032:analysis
D002395:Catecholamines; D017981:Receptors, Neurotransmitter; D008694:Methamphetamine