The chemoattractant des-Arg74-C5a regulates the expression of its own receptor on a monocyte-like cell line.
The interaction of the chemoattractant des-Arg74-C5a (C5a des Arg) with its receptor on a human monocyte-like cell line, U-937, was examined. The data obtained suggest that C5a des Arg receptor expression is regulated by the extracellular concentration of C5a des Arg itself.
D003994:Bucladesine / Q000494:pharmacology; D002460:Cell Line; D002634:Chemotaxis, Leukocyte; D003182:Complement C5 / Q000031:analogs & derivatives* / Q000378:metabolism; D015937:Complement C5a, des-Arginine; D003432:Cross-Linking Reagents; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D009000:Monocytes / Q000378:metabolism*; D044087:Receptor, Anaphylatoxin C5a; D011951:Receptors, Complement / Q000187:drug effects / Q000378:metabolism*; D013388:Succinimides
D003182:Complement C5; D015937:Complement C5a, des-Arginine; D003432:Cross-Linking Reagents; D044087:Receptor, Anaphylatoxin C5a; D011951:Receptors, Complement; D013388:Succinimides; D003994:Bucladesine; C035760:bis(sulfosuccinimidyl)suberate