Transfer of blood lymphocytes and macrophages between histocompatible progressor and regressor chickens infected with Rous sarcoma virus.
The development of histocompatible White Leghorn (progressor) and Arkansas Regression (regressor) chicken lines was described. When challenged with Rous sarcoma virus, progressor chickens developed fatal tumors while the regressor chickens eliminated the sarcoma. When sensitized histocompatible peritoneal macrophages and blood lymphocytes were transferred from regressor donors to progressor recipients, they both eradicated growing tumors. Histoincompatible cells were ineffective in inducing tumor remission. Within the two age groups tested, the sensitized blood lymphocytes and macrophages were only effective when transferred between age-matched donor and recipient chickens.
D000367:Age Factors; D000818:Animals; D002645:Chickens / Q000235:genetics / Q000276:immunology; D006238:Haploidy; D006648:Histocompatibility; D007694:Killer Cells, Natural / Q000276:immunology; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology / Q000637:transplantation*; D001357:Sarcoma, Avian / Q000276:immunology* / Q000628:therapy