Acquired loss of red-cell Wj antigen in a patient with Hodgkin's disease.
A patient with Hodgkin's disease became temporarily Wj-negative with alloanti-Wj in his serum. Four human autoantibodies, and 1 of 2 murine monoclonal antibodies, with serological characteristics of anti-Wj were nonreactive with his red cells, confirming that they have anti-Wj specificity. Six siblings of the patient are all Wj-positive. The patient was also temporarily Anton-negative, and cross-testing between Wj and Anton red cells and antisera showed mutual compatibility, indicating that the antigens are the same. The patient and 3 of his 6 siblings are also of the rare Lu: - 13 phenotype, providing the first evidence that this is an inherited characteristic.
D000328:Adult; D001787:Blood Group Incompatibility; D001788:Blood Grouping and Crossmatching; D004912:Erythrocytes / Q000276:immunology*; D006689:Hodgkin Disease / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007518:Isoantibodies / Q000276:immunology; D008188:Lutheran Blood-Group System / Q000032:analysis / Q000235:genetics / Q000276:immunology*; D008297:Male; D010375:Pedigree; D010641:Phenotype
D007518:Isoantibodies; D008188:Lutheran Blood-Group System