[Biological effect of fibrous mineral dust. II. The neurotoxic effect of products of the thermal degradation of chrysotile].
In experiments on animals the effect of heating chrysotile at 600 degrees C upon their biological action has been tested. Three chrysotile samples used in the Polish industry (MX-22 from deposits in Rhodesia, N-239 from Canada and PRZ-1-71 from deposits in the USSR (have been investigated). An X-ray diffraction analysis of heated chrysotile samples exhibited the total lack of lines characteristic for crystal substances in MX-22 and N-239 samples, whereas in the PRZ-1-71 sample the chrysotile content was about 20% of that in a non-heated sample. Intraperitoneal administration of a suspension of 100 mg of the dust brought about nervous system disturbances (shambling, atrophy of the response to ache, drop of internal body temperature and other (and finally-death of all experimental animals. Male rats survived longer from dust administration till the disturbances followed by death, i.e. from 8 hrs to 3 days, whereas female rats survived from 45 minutes to 24 hours only.
D000818:Animals; D001194:Asbestos / Q000009:adverse effects*; D017632:Asbestos, Serpentine; D005260:Female; D006358:Hot Temperature / Q000009:adverse effects; D008297:Male; D009069:Movement Disorders / Q000209:etiology*; D010316:Particle Size; D051381:Rats; D011919:Rats, Inbred Strains; D012021:Reflex, Abnormal / Q000209:etiology; D012640:Seizures / Q000209:etiology*
D017632:Asbestos, Serpentine; D001194:Asbestos
Biologiczne działanie włóknistych pyłów mineralnych. II. Neurotoksyczne działanie produktow termicznej degradacji chryzotylu.