title: Stimulation of cyclic AMP production in chick renal tissue by cadmium and manganese.
abstract: The effects of cadmium on production of cyclic AMP by partially purified chick renal plasma membrane preparations and binding of 125I-parathyrin to the membranes have been investigated. At certain concentrations Cd2+ ions (and Mn2+ ions) markedly stimulated the production of cyclic AMP by the tissue. It was found that concentrations of Cd2+ roughly in the same range were also capable of stimulating binding of 125I-parathyrin to the membrane preparations.
mesh_terms: D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002417:Cattle; D002462:Cell Membrane / Q000378:metabolism; D002645:Chickens; D000242:Cyclic AMP / Q000096:biosynthesis*; D007668:Kidney / Q000378:metabolism*; D007700:Kinetics; D008345:Manganese / Q000494:pharmacology*; D010281:Parathyroid Hormone / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D018016:Receptors, Parathyroid Hormone
chemical_list: D010281:Parathyroid Hormone; D011956:Receptors, Cell Surface; D018016:Receptors, Parathyroid Hormone; D008345:Manganese; D000242:Cyclic AMP; D002118:Calcium