title: Transmission of bovine leukemia virus (BLV) to immunocompromised monkeys: evidence for persistent infection.
abstract: Splenectomized or irradiated adult and untreated baby macacques were infected with bovine leukemia virus from continuously virus producing fetal lamb kidney cell cultures. Persisting high antibody titers were followed for 4 years in the adult and 16 months in the baby monkeys, using an ELISA technique. With the exception of a persistent leukocytosis in one adult monkey, the animals remained healthy throughout the observation period. Transfer of lymphocytes from this animal to a seronegative recipient led to anti-BLV seroconversion with a lag of 5 months. All other transfer experiments showed a negative result. Virus could be recovered from the newly infected baby macacques by means of lymphocyte/fetal lamb kidney cell cocultivation for up to 4 weeks after inoculation. All other attempts to recover virus from the infected animals at a later point were unsuccessful.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D007116:Immunization, Passive; D001909:Leukemia Virus, Bovine / Q000472:pathogenicity*; D007942:Leukemia, Experimental / Q000276:immunology / Q000382:microbiology* / Q000635:transmission; D008214:Lymphocytes / Q000276:immunology; D008252:Macaca fascicularis; D012190:Retroviridae / Q000472:pathogenicity*
chemical_list: D000914:Antibodies, Viral