Excitatory amino acids in the chick retina: possible involvement of cyclic guanosine monophosphate.
An investigation has been made of the ability of excitatory amino acids to alter the levels of chick retinal cyclic guanosine monophosphate (GMP). Kainic acid, N-methyl-D-aspartic acid and quisqualic acid each produced dose-related increases in cyclic GMP, and these could be attenuated by the addition of excitatory amino acid antagonists. It appears likely that in addition to its proposed role in visual transduction, this nucleotide may be involved in excitatory amino acid function in the chick retina.
D000596:Amino Acids / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D002118:Calcium / Q000502:physiology; D002645:Chickens; D006152:Cyclic GMP / Q000378:metabolism*; D066298:In Vitro Techniques; D012160:Retina / Q000378:metabolism*; D013268:Stimulation, Chemical
D000596:Amino Acids; D006152:Cyclic GMP; D002118:Calcium