Effect of dithiocarbamate fungicides and thiurams on 3H-haloperidol binding in rat brain.
Dithiocarbamates and disulfiram have been shown to be neurotoxic. As one biochemical indicator of the toxicity, dopamine-beta-hydroxylase is inhibited in the brain. Consequently, noradrenaline synthesis is decreased and dopamine tends to accumulate in the brain. It was decided to examine whether cerebral dopaminergic D2-receptor binding is affected by these agents after their short-term administration to rats. It appeared that ferbam, maneb, nabam, zineb, disulfiram, thiram and ethylene thiourea did not change significantly D2-receptor binding at doses which were already overtly toxic.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005031:Ethylenethiourea / Q000494:pharmacology; D005659:Fungicides, Industrial / Q000494:pharmacology* / Q000633:toxicity; D006220:Haloperidol / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects; D013859:Thiocarbamates / Q000494:pharmacology* / Q000633:toxicity
D005659:Fungicides, Industrial; D011954:Receptors, Dopamine; D013859:Thiocarbamates; D005031:Ethylenethiourea; D006220:Haloperidol