[Prognostic factors influencing the improvement of allogeneic bone marrow transplantation in acute leukemia based on a national survey in Japan].
The records of 115 patients with acute leukemia who underwent allogeneic bone marrow transplantation from 1975 through August 1984 were collected by a national survey in Japan. One-year survival significantly improved from 9% in group I (before 1980) to 52% in group II (after 1981). Multivariate analysis indicated that selection of the patients in remission without infection at the time of transplant, as well as progress in technology of total body irradiation and selection of a platelet donor with negative cytomegalovirus titer resulted in the significant improvement in survival after 1981.
D000208:Acute Disease; D000328:Adult; D000704:Analysis of Variance; D016026:Bone Marrow Transplantation; D003524:Cyclosporins / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000517:prevention & control; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007564:Japan; D007938:Leukemia / Q000401:mortality / Q000628:therapy*; D008297:Male; D011379:Prognosis; D014184:Transplantation, Homologous / Q000401:mortality*
D003524:Cyclosporins