Effect of stimulation of left atrial receptors on the concentration of adrenocorticotropic hormone (ACTH).
The effect of stimulating atrial receptors on the concentration of ACTH in jugular venous blood was examined in dogs anaesthetized with chloralose. The atrial receptors were stimulated by stretching the pulmonary vein-atrial junctions and the atrial appendage. In 13 experimental runs in 9 dogs, it was found that the concentration of ACTH fell in 11 and remained unchanged in 2. The average concentration during control periods was 76.5 +/- 13.6 (pg/ml) and that during stimulation was 60.0 +/- 11.8 (pg/ml). This difference was statistically significant (p less than 0.05; 2 tailed t test). Cutting (2 dogs) or cooling the cervical vagi (3 dogs) abolished this response. It is concluded that stimulation of left atrial receptors reduces the concentration of ACTH in plasma.
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D016275:Atrial Function; D003080:Cold Temperature; D004285:Dogs; D006325:Heart Atria / Q000294:innervation* / Q000378:metabolism; D010812:Physical Stimulation; D011667:Pulmonary Veins / Q000502:physiology; D011984:Sensory Receptor Cells / Q000502:physiology*; D013997:Time Factors; D014630:Vagus Nerve / Q000502:physiology / Q000601:surgery
D000324:Adrenocorticotropic Hormone