Neurochemical studies on GABAergic and aminergic systems in the rat brain following acute and chronic piracetam administration.
In view of the metabolic and behavioural effects of piracetam (P), a cyclic derivative of gamma-aminobutyric acid (GABA), in experimental animals and in man, it was of interest to investigate the effect of acute or chronic administration of the compound on the function of different brain neurotransmitter systems. P was ineffective in modifying either synthesis release, uptake or post- synaptic binding sites for GABA. Acute P injection decreased dose-dependently cGMP levels in the rat cerebellum. Moreover, this effect was not mediated through a GABAergic mechanism. An acute challenge with Piracetam 15 days after chronic treatment with the compound increased DOPAC levels in the striatum and counteracted haloperidol-induced PRL rise. Furthermore, chronic P administration increased normetanephrine levels in the cerebral cortex, an index of the release of norepinephrine at the synaptic level, and induced a desensitization of beta-adrenoceptors in this same brain area. In conclusion, besides the well documented effect of P on cholinergic neurons, P seems to exert its biological and behavioural effects through activation of catecholaminergic mechanisms.
D000818:Animals; D001665:Binding Sites; D001923:Brain Chemistry / Q000187:drug effects*; D002531:Cerebellum / Q000032:analysis; D006152:Cyclic GMP / Q000032:analysis; D006220:Haloperidol / Q000494:pharmacology; D007858:Learning / Q000187:drug effects; D008297:Male; D009638:Norepinephrine / Q000032:analysis; D010743:Phospholipids / Q000378:metabolism; D010889:Piracetam / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D011388:Prolactin / Q000097:blood; D011760:Pyrrolidinones / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011954:Receptors, Dopamine / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects
D010743:Phospholipids; D011760:Pyrrolidinones; D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D011985:Receptors, Serotonin; D011388:Prolactin; D006152:Cyclic GMP; D006220:Haloperidol; D009638:Norepinephrine; D010889:Piracetam