Ethanol induced conformational changes of the peptide ligands for the opioid receptors and their relevance to receptor interaction.
The FT-IR (Fourier Transform Infrared) Spectrum of [Met 5]-enkephalinamide in aqueous solution shows the presence of both the beta-turn and beta-sheet conformations. The beta-turn and beta-sheet conformations of enkephalins have been proposed to play a role in receptor selectivity. Addition of ethanol alters these secondary structural features and hence the effect of ethanol on ligand-receptor interaction may be mediated primarily through conformational changes of the ligand rather than those of the receptor.
D000818:Animals; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005583:Fourier Analysis; D010455:Peptides / Q000378:metabolism*; D011487:Protein Conformation; D011957:Receptors, Opioid / Q000378:metabolism*
D010455:Peptides; D011957:Receptors, Opioid; D000431:Ethanol; D004744:Enkephalin, Methionine; C021055:Met-enkephalinamide