Erythrocyte lipid peroxidation and (Na+ + K+)-ATPase activity in cholesterol fed rabbits.
Cholesterol, phospholipid and lipid peroxide levels in plasma and erythrocytes as well as membrane-bound (Na+ + K+)-ATPase activity were determined in rabbits fed a high-cholesterol diet for 3 months. While cholesterol feeding caused an increase in lipid peroxide levels, (Na+ + K+)-ATPase activity was found to be reduced. According to this, we can assume that, in high-cholesterol fed rabbits, elevated lipid peroxides may be one of the responsible factors for the decreased erythrocyte (Na+ + K+)-ATPase activity.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004912:Erythrocytes / Q000378:metabolism*; D008054:Lipid Peroxides / Q000097:blood*; D011817:Rabbits; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*
D002791:Cholesterol, Dietary; D008054:Lipid Peroxides; D002784:Cholesterol; D000254:Sodium-Potassium-Exchanging ATPase