FMRFamide suppresses kappa opiate induced feeding in the mouse.
Intracerebroventricular administration of 0.01-1.0 micrograms of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) to mice suppressed feeding induced by the specific kappa opiate agonist, U-50, 488H. This suggests that FMRFamide, or FMRFamide-like neuropeptides, may have a role in the control of kappa opioid mediated feeding in the mouse.
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000818:Animals; D019835:FMRFamide; D005247:Feeding Behavior / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects*; D017473:Receptors, Opioid, kappa
D009842:Oligopeptides; D011759:Pyrrolidines; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D009270:Naloxone; D019835:FMRFamide; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer