Polymorphonuclear leukocyte dysfunction associated with feline leukaemia virus infection.
The chemiluminescent characteristics of enriched (greater than 95%) peripheral blood polymorphonuclear leukocyte populations (PMN) from normal and feline leukaemia virus (FeLV)-infected cats were investigated. FeLV-infected cats demonstrated a significantly lower (P less than 0.001) PMN chemiluminescent response when compared to the response of normal age-matched controls. Normal PMN treated with FeLV-infected cat serum exhibited a depressed response in comparison to control cells. A titration of serum from infected cats supplemented with normal serum revealed a titratable suppression of chemiluminescence with increasing concentration of serum from the infected cats. However, PMN from FeLV-infected cats treated with normal serum displayed a slight increase in chemiluminescence over the same cells in autologous serum. The addition of inactivated FeLV to normal PMN caused a titratable decrease in chemiluminescence.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002415:Cats; D005256:Leukemia Virus, Feline / Q000276:immunology* / Q000528:radiation effects; D007942:Leukemia, Experimental / Q000276:immunology*; D008163:Luminescent Measurements; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism; D013047:Specific Pathogen-Free Organisms; D014466:Ultraviolet Rays; D014766:Viremia
D000956:Antigens, Viral