Regression of rat mammary tumors associated with suppressed growth hormone.
Serum growth hormone (GH) was suppressed in female rats bearing mammary tumors induced by 7, 12, dimethylbenz(a)anthracene (DMBA) or N-nitrosomethylurea(NMU). Serum GH was suppressed due to treatment with a human GH analog produced by the plerocercoid stage of the tapeworm Spirometra mansonoides. Rats treated with plerocercoid growth factor (PGF) via plerocercoid infection had accelerated growth rates despite marked reductions in GH levels. Approximately two-thirds of the mammary tumors induced by either DMBA or NMU regressed during three weeks of exposure to PGF while most of the control tumors continued to grow. The data support an important regulatory role for GH in growth of mammary tumors in rats.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006133:Growth Substances / Q000494:pharmacology*; D036341:Intercellular Signaling Peptides and Proteins; D008325:Mammary Neoplasms, Experimental / Q000097:blood / Q000473:pathology*; D008770:Methylnitrosourea; D009376:Neoplasms, Hormone-Dependent / Q000097:blood / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011981:Receptors, Prolactin
D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D011956:Receptors, Cell Surface; D011960:Receptors, Estrogen; D011981:Receptors, Prolactin; C043871:plerocercoid growth factor; D015127:9,10-Dimethyl-1,2-benzanthracene; D008770:Methylnitrosourea; D013006:Growth Hormone