[Effect of mineralocorticoids on the Na, K-ATPase activity of the rat brain].
The effect of desoxycorticosterone (DOC) on Na, K-ATPase activity was studied in vivo and in vitro on microsomal rat brain fractions. An hour after intramuscular administration of DOC a noticeable increase in the enzyme activity was observed. Preincubation of microsomal brain fractions with 5 and 15 mkg/ml of DOC caused a decrease in Na, K-ATPase activity, with the results evident 3-5 minutes after the addition of the hormone into the incubation medium. The idea of a two-phase hormonal effect is suggested. It is likely that desoxycorticosterone effect is realized both by the direct influence, on Na, K-ATPase of the brain plasma membrane and by the influence on the biosynthesis.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D003900:Desoxycorticosterone / Q000494:pharmacology; D066298:In Vitro Techniques; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D008901:Mineralocorticoids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013997:Time Factors
D008901:Mineralocorticoids; D003900:Desoxycorticosterone; D000254:Sodium-Potassium-Exchanging ATPase
Vliianie mineralokortikoidov na aktivnost' Na, K-ATFazy golovnogo mozga krys.