TRH analogue with C-terminal thioamide group. Synthesis, receptor binding, TSH-releasing activity and alpha-MSH-releasing activity.
A new TRH analogue containing a C-terminal thioamide group was synthesized. This peptide was shown to have receptor-binding affinity, and TSH- as well as alpha-MSH-releasing activities very similar to native TRH.
D000818:Animals; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D011898:Ranidae; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism; D018025:Receptors, Thyrotropin-Releasing Hormone; D013972:Thyrotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology
D011956:Receptors, Cell Surface; D018025:Receptors, Thyrotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D009074:Melanocyte-Stimulating Hormones; C047483:pyroglutamyl-histidyl-proline thioamide; D011761:Pyrrolidonecarboxylic Acid