Nifedipine as a substitute for converting enzyme inhibitors in the treatment of renovascular hypertension.
Nifedipine long acting tablets were substituted for converting enzyme inhibitors in eight patients with renovascular hypertension. A significant drop in blood pressure was observed. Nifedipine was shown to be as effective (in lowering blood pressure) as a drug that acts directly on the renin angiotensin system. These data offer support for previously reported findings that the action of angiotensin II is calcium mediated.
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*
D000806:Angiotensin-Converting Enzyme Inhibitors; D003692:Delayed-Action Preparations; D009543:Nifedipine