The effect of ouabain on basal and thyroid hormone-stimulated muscle oxygen consumption.
In vivo triiodothyronine treatment (T3) increased soleus muscle oxygen consumption (QO2) when measured in vitro. Ouabain significantly decreased T3-induced muscle QO2, but not basal muscle QO2. Ouabain-sensitive metabolic processes in muscle, which essentially represents Na-K-ATPase activity, accounted for approximately 85% of the increased energy utilization by muscles that was caused by T3 treatment.
D000818:Animals; D007700:Kinetics; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase