Genetic studies on murine susceptibility to herpes simplex keratitis.
We studied the influence of lgh-linked genes on the development of keratopathy after corneal inoculation with herpes simplex virus (HSV). Using congenic strains of mice, we found that the lgh-1 gene locus, or genes closely linked to it, influence the clinical expression of HSV infection. Mice with the lgh-1e or lgh-1d allotype routinely developed severe keratopathy after HSV corneal inoculation, whereas congenic strains with lgh-1a or lgh-1b allotype were less susceptible. Cell-mediated immune responses to HSV also differed between susceptible and resistant murine strains. We interpret our results to imply a genetic influence on cell-mediated, acquired immune responses to HSV infection.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D003315:Cornea / Q000473:pathology; D004198:Disease Susceptibility; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics; D007136:Immunoglobulins / Q000235:genetics; D007635:Keratitis, Dendritic / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics* / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology
D000914:Antibodies, Viral; D006183:H-2 Antigens; D007136:Immunoglobulins