Improved graft patency associated with altered platelet function induced by marine fatty acids in dogs.
Female mongrel dogs fed a marine fish diet rich in long-chain polyenoic fatty acids had improved patency of small-diameter arterial prosthetic grafts as compared to controls. Also, in vivo platelet function as measured by bleeding times was significantly prolonged. Eicosapentaenoic acid, not found in the serum of control animals, was present in relatively high concentrations in both the serum and a platelet-rich fraction of the marine oil-fed group. Eicosapentaenoic acid, unlike arachidonic acid, does not induce platelet aggregation and this phenomonon may account for the altered platelet function demonstrated in our animals and hence the improved graft patency. These data lend further support to the role of platelets in determining the patency of vascular grafts.
D000818:Animals; D001760:Bleeding Time; D001777:Blood Coagulation; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D001807:Blood Vessel Prosthesis; D004032:Diet; D004285:Dogs; D015118:Eicosapentaenoic Acid / Q000494:pharmacology; D005227:Fatty Acids / Q000032:analysis / Q000494:pharmacology*; D005260:Female; D005263:Femoral Artery / Q000473:pathology / Q000601:surgery; D005395:Fish Oils; D005399:Fishes; D006083:Graft Occlusion, Vascular; D008055:Lipids / Q000032:analysis; D008297:Male; D009821:Oils / Q000494:pharmacology; D010979:Platelet Function Tests
D005227:Fatty Acids; D005395:Fish Oils; D008055:Lipids; D009821:Oils; C033266:Menhaden oil; D015118:Eicosapentaenoic Acid