[Effect of dimedrol on the function of the neuromuscular synapse and the generation of action potentials by motor nerve fibers].
Microelectrode registration of synaptic potentials in the frog cutaneous-pectoris muscle has shown dimedrol (7.9 X 10(-5) M) to act on synaptic transmission decreasing the quantal content, estimated by mean EPP amplitude to mean miniature EPP amplitude ratio, the quantal content calculated by variation coefficient of EPP amplitude being unaffected. The data suggest possible transmitter release and depletion of mediator stock. The experiments on isolated motor nerve fibers have demonstrated dimedrol to cause the increase in transmitter release probability by widening the action potentials in the terminals and thus enhancing Ca2+ influx.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004155:Diphenhydramine / Q000494:pharmacology*; D006639:Histidine / Q000494:pharmacology; D009412:Nerve Fibers / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects*; D011898:Ranidae; D011901:Ranvier's Nodes / Q000187:drug effects; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects
D006639:Histidine; D004155:Diphenhydramine
Vliianie dimedrola na funktsiiu nervno-myshechnogo sinapsa i generatsiiu potentsialov deĭstviia motornymi nervnymi voloknami.