Mouse polyoma virus and adenovirus replication in mouse cells temperature-sensitive in DNA synthesis.
Mouse adenovirus multiplies, apparently without impediment, in temperature-inactivated ts A1S9, tsC1 and ts2 mouse fibroblasts. Thus, the DNA of mouse adenovirus can replicate in the absence of functional DNA topoisomerase II, a DNA-chain-elongation factor, and a protein required for traverse of the G1/S interface, respectively, encoded in the ts A1S9, tsC1 and ts2 genetic loci. These results are compared with those obtained with polyoma virus.
D000256:Adenoviridae / Q000254:growth & development* / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D004261:DNA Replication; D004279:DNA, Viral / Q000096:biosynthesis; D051379:Mice; D009154:Mutation; D011120:Polyomavirus / Q000254:growth & development* / Q000378:metabolism; D013696:Temperature; D014779:Virus Replication
D004279:DNA, Viral; D004247:DNA