Short-term effects of calcium carbonate, lactate, and gluconate on the calcium-parathyroid axis in normal elderly men and women.
We evaluated the impact of three calcium salts on the calcium-parathyroid axis in healthy elderly volunteers. Fasting subjects were administered a standardized 1-g calcium load on three occasions, using calcium carbonate, lactate, and gluconate in random sequence with 8 oz milk or orange juice as carrier. Blood and urine were collected at baseline and for 6 h following the calcium load. Each salt rapidly increased the serum-calcium concentration and urinary-calcium excretion. Response duration was shorter with gluconate than with the other salts, but peak responses were similar for all preparations. Urinary-calcium excretion was slightly lower when orange juice replaced milk, but calcemic responses were not different. Changes in immunoreactive-parathyroid hormone and renal-phosphorus handling did not differ among calcium salts. Except for a shorter duration of effect with gluconate, all three calcium salts provided similar short-term suppression of the parathyroid axis.
D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000008:administration & dosage* / Q000378:metabolism; D002119:Calcium Carbonate / Q000494:pharmacology; D002125:Calcium Gluconate / Q000494:pharmacology; D000242:Cyclic AMP / Q000652:urine; D005260:Female; D006801:Humans; D007773:Lactates / Q000494:pharmacology; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000187:drug effects*; D010281:Parathyroid Hormone / Q000378:metabolism; D010710:Phosphates / Q000652:urine
D007773:Lactates; D010281:Parathyroid Hormone; D010710:Phosphates; D019344:Lactic Acid; D000242:Cyclic AMP; D002119:Calcium Carbonate; D002125:Calcium Gluconate; D002118:Calcium