Tumor-promoting phorbol esters and vanadate alter the sensitivity of HeLa S3 cells to poliovirus type 1.
Treatment of HeLa S3 cells with tumor-promoting phorbol esters and vanadate increased their sensitivity to type 1 poliovirus. Since the sensitization could not be accounted for by increased virus binding or virus production, it appears that virus entry was facilitated by the treatments. When HeLa S3 cells were incubated with TPA for prolonged periods of time, they became resistant to poliovirus due to reduced ability to bind the virus.
D002462:Cell Membrane / Q000378:metabolism / Q000382:microbiology; D006367:HeLa Cells; D006801:Humans; D015240:Phorbol 12,13-Dibutyrate; D010703:Phorbol Esters / Q000494:pharmacology; D010704:Phorbols / Q000494:pharmacology*; D017955:Poliovirus / Q000378:metabolism / Q000502:physiology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014638:Vanadates; D014639:Vanadium / Q000494:pharmacology*
D010703:Phorbol Esters; D010704:Phorbols; D014639:Vanadium; C008876:phorbol-12,13-didecanoate; D015240:Phorbol 12,13-Dibutyrate; D014638:Vanadates; D013755:Tetradecanoylphorbol Acetate