title: Mechanisms of inflammation and leukocyte chemotaxis in the rheumatic diseases.
abstract: Understanding the mechanisms of inflammatory cell accumulation, as well as how such cells mediate tissue destruction, provides better insights into the pathogenesis and therapeutics of the rheumatic diseases. This article discusses the role of the inflammatory process in normal immune function, the mechanisms of inflammatory cell accumulation, and how the local accumulation of inflammatory cells can lead to the clinical signs and symptoms associated with rheumatic disorders.
mesh_terms: D000906:Antibodies / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000502:physiology; D001172:Arthritis, Rheumatoid / Q000150:complications; D001696:Biomechanical Phenomena; D002630:Chemotactic Factors / Q000096:biosynthesis / Q000502:physiology; D002634:Chemotaxis, Leukocyte; D003165:Complement System Proteins / Q000378:metabolism; D003602:Cytotoxicity, Immunologic; D005089:Exocytosis; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology; D006968:Hypersensitivity, Delayed / Q000503:physiopathology; D007107:Immune System / Q000502:physiology; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology; D007962:Leukocytes / Q000502:physiology; D050356:Lipid Metabolism; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000502:physiology; D010587:Phagocytosis; D011956:Receptors, Cell Surface / Q000502:physiology; D012216:Rheumatic Diseases / Q000473:pathology / Q000503:physiopathology*; D013585:Synovitis / Q000209:etiology / Q000276:immunology
chemical_list: D000906:Antibodies; D000936:Antigen-Antibody Complex; D002630:Chemotactic Factors; D011956:Receptors, Cell Surface; D009240:N-Formylmethionine Leucyl-Phenylalanine; D003165:Complement System Proteins