[Cytotoxic action of doxorubicin and daunomycin on human lung cancer cells].
The cytotoxic activity of two anthracycline antibiotics, i. e. doxorubicin and daunomycin against the cells of human lung cancer was estimated. Tumors resected from 19 patients, including 8 with adenocarcinoma, 10 with squamous cell cancer and 1 with small cell cancer were used. The tumor fragments were placed into diffusion chambers and implanted into the abdominal cavity of mice CBA. The effect was estimated autoradiographically on the 6th-7th day of cultivation after administration of doxorubicin or daunomycin to the animals in the maximum tolerance doses. The number of the tumors sensitive to doxorubicin and daunomycin amounted to 79 and 89 per cent, respectively. As compared to doxorubicin, daunomycin lowered the proportion of the DNA-synthesizing cells in the drug sensitive xenografts of lung cancer more significantly. With the use of daunomycin the synthesis of DNA in the tumor cells was inhibited more intensively than with the use of doxorubicin. The cytotoxic effect of daunomycin and doxorubicin did not depend on the tumor histological structure. The experimental data suggested that daunomycin would be highly efficient in chemotherapy of patients with lung cancer.
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D018288:Carcinoma, Small Cell / Q000188:drug therapy*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D003630:Daunorubicin / Q000627:therapeutic use*; D004317:Doxorubicin / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation
D004317:Doxorubicin; D003630:Daunorubicin
Tsitotoksicheskoe deĭstvie doksorubitsina i daunomitsina na kletki raka legkogo cheloveka.