title: Mammary tumors in feral mice lacking MuMTV DNA.
abstract: Two mammary tumors developed in feral mice treated with dimethylbenzanthracene. The tumors, livers, and spleens of these animals contained no MuMTV proviral DNA. Neither tumor had amplified or rearranged int-1 or int-2 loci. This demonstrates that mammary tumorigenesis can occur in mice in the absence of endogenous and exogenous MuMTV.
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000818:Animals; D001483:Base Sequence; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced; D003101:Collodion; D004279:DNA, Viral / Q000032:analysis* / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D005814:Genes, Viral; D008099:Liver / Q000166:cytology; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics; D009115:Muridae; D010209:Paper; D013154:Spleen / Q000166:cytology
chemical_list: D004279:DNA, Viral; D015127:9,10-Dimethyl-1,2-benzanthracene; D003101:Collodion