title: High murine mammary tumor virus expression in milk in a low mammary tumor mouse strain and high incidence of mammary tumor in hybrids produced by crossing with another low mammary tumor mouse strain.
abstract: Large amounts of murine mammary tumor virus (MMTV) were expressed in milk from a low mammary tumor mouse strain called II-TES, established by crossbreeding DBA/2 mouse strain with two strains of Japanese pet mouse origin. The reciprocal hybrids of the II-TES strain and OZ-F strain, another low mammary tumor strain of Japanese pet mouse origin, developed early-appearing mammary tumors at a high rate, and large quantities of MMTV were expressed in the milk. These findings suggest that different regulatory genes control MMTV expression and mammary tumorigenesis.
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D005786:Gene Expression Regulation; D006824:Hybridization, Genetic; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000209:etiology / Q000382:microbiology* / Q000473:pathology; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics / Q000302:isolation & purification*; D051379:Mice; D008811:Mice, Inbred DBA; D008892:Milk / Q000382:microbiology*; D009857:Oncogenes