title: Epidermodysplasia verruciformis associated with Bowen's carcinoma, B lymphocytopenia and decreased immune functions.
abstract: A case of epidermodysplasia verruciformis associated with Bowen's carcinoma, persistent B lymphocytopenia and decreased immune functions is reported. Human papilloma virus 5 (HPV-5) DNA was shown to be associated with the DNA from the tumor tissue by Southern blot hybridization using P-labeled HPV DNA sequences cloned on plasmid vectors. The associated Bowen's carcinoma in our case may be caused by multiple-factor relationships which include (a) an oncogenic potential of infected virus; (b) an inherited abnormality in immune function, and (c) the decreased immune function resulting from the viral infection itself. A marked B lymphocytopenia appears to be associated with persistent viral infection.
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D001402:B-Lymphocytes / Q000145:classification / Q000276:immunology*; D001913:Bowen's Disease / Q000150:complications* / Q000276:immunology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D003001:Cloning, Molecular; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007154:Immune System Diseases / Q000150:complications*; D007970:Leukopenia / Q000150:complications* / Q000276:immunology; D008297:Male; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D012878:Skin Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology; D014412:Tumor Virus Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral