"Endogenous ligands" of benzodiazepine receptors, their structural analogs. Development of new psychotropic drugs.
This paper presents a review of literature data and results from investigations designed to determine the relation between structure, affinity to benzodiazepine receptors and pharmacological activity of possible endogenous ligands of benzodiazepine receptors and their electronic structural analogs. Structural variations of endogenous ligands of benzodiazepine receptors are substantiated to manifest themselves as active psychotropic drugs. On the basis of these considerations and experimental data, compounds with psychotropic activity and electronic structure, resembling that of "endogenous ligands" of benzodiazepine receptors, were developed.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines / Q000378:metabolism / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007288:Inosine / Q000378:metabolism / Q000494:pharmacology; D009536:Niacinamide / Q000378:metabolism / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000378:metabolism* / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*
D011619:Psychotropic Drugs; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D009536:Niacinamide; D007288:Inosine