Relationships between structure and function of lactogenic hormones.
Lactogenic activity of several hormone derivatives obtained by chemical modifications of lysine residues was studied by radioreceptor assay. The relationships between structure and binding to lactogenic receptors are discussed taking into account lysine residue positions liable to be involved in the location of lactogenic function.
D000595:Amino Acid Sequence; D000818:Animals; D001894:Borohydrides; D002462:Cell Membrane / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D013006:Growth Hormone / Q000031:analogs & derivatives* / Q000378:metabolism; D007460:Iodoacetamide; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008745:Methylation; D010928:Placental Lactogen / Q000031:analogs & derivatives* / Q000378:metabolism; D011247:Pregnancy; D011388:Prolactin / Q000031:analogs & derivatives* / Q000378:metabolism; D011817:Rabbits; D011869:Radioligand Assay; D011956:Receptors, Cell Surface / Q000378:metabolism; D018000:Receptors, Peptide; D013329:Structure-Activity Relationship
D001894:Borohydrides; D011956:Receptors, Cell Surface; D018000:Receptors, Peptide; C028202:placental lactogen receptor; D011388:Prolactin; D013006:Growth Hormone; D010928:Placental Lactogen; D007460:Iodoacetamide