Autonomic effects of centrally administered dermorphin in conscious rabbits.
The administration of 1 microgram dermorphin into the mesencephalic ventricle of conscious rabbits modifies some autonomic functions, heart rate, respiratory rate and temperature decreasing in a statistically significant way. Naloxone completely reverses such effects. Pretreatment with drugs which inhibit serotoninergic, catecholaminergic, Gabaergic and cholinergic systems does not affect these central dermorphin actions.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D004050:Ditiocarb / Q000494:pharmacology; D010134:Fenclonine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D010852:Picrotoxin / Q000494:pharmacology; D011817:Rabbits; D012119:Respiration / Q000187:drug effects
D001285:Atropine; D004050:Ditiocarb; D010134:Fenclonine; D009270:Naloxone; D009842:Oligopeptides; D018847:Opioid Peptides; D010852:Picrotoxin; C030058:dermorphin