title: Effects of chronic treatment with benzodiazepine receptor ligands on cortical adrenoceptors.
abstract: We report the effects of kindling with the benzodiazepine partial inverse agonist, FG 7142 on adrenoceptor binding in mouse cerebral cortex. Twelve once-daily injections of FG 7142 caused a statistically significant increase in the density of both alpha 2- and beta-adrenoceptor binding sites, seven days after the last injection. Despite the marked effects of FG 7142 on adrenoceptors, there were no changes in either alpha 2- or beta-adrenoceptor binding after prolonged treatment with the benzodiazepine, flurazepam.
mesh_terms: D000818:Animals; D002243:Carbolines / Q000494:pharmacology; D002540:Cerebral Cortex / Q000378:metabolism*; D005479:Flurazepam / Q000494:pharmacology; D008297:Male; D051379:Mice; D011869:Radioligand Assay; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011963:Receptors, GABA-A / Q000187:drug effects*; D013997:Time Factors
chemical_list: D002243:Carbolines; D011941:Receptors, Adrenergic; D011963:Receptors, GABA-A; C035874:FG 7142; D005479:Flurazepam