title: The second messenger system in the stimulation of cellular growth.
abstract: A survey is given of recent results on ionic fluxes as fast events following proliferative stimulation of cells. From this, a hypothesis of interactions of ionic fluxes, pH and cAMP concentration shifts as a system of second messengers leading to cellular growth is developed. Own X-ray microanalytical results from hepatocytes in vivo of young and adult rats are shown to be consistent with that hypothesis.
mesh_terms: D000375:Aging; D002455:Cell Division; D002843:Chromatin / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D007477:Ions; D008099:Liver / Q000166:cytology / Q000254:growth & development*; D008954:Models, Biological
chemical_list: D002843:Chromatin; D007477:Ions; D000242:Cyclic AMP