[Direct interaction of tricyclic antidepressants with opiate binding sites in the bovine adrenal medulla].
This note reports the interaction of three currently used tricyclic antidepressant drugs (clomipramine, imipramine and amitriptyline) with delta, mu and kappa opioid binding sites in the bovine adrenal medulla. Clomipramine was the only drug interacting with delta and mu sites. On the contrary, all three drugs showed a significant interactions with subtypes of the kappa binding site. Clomipramine was the most active on the kappa 2 and kappa 3 subtypes while amitriptyline showed the highest interaction with the kappa 1 subtype. On the contrary the tricyclic cyproheptadine did not present any interaction with opioid binding sites in our system. This interaction between tricyclic antidepressants and opioid binding sites might be the origin of their analgesic action.
D000313:Adrenal Medulla / Q000378:metabolism*; D000639:Amitriptyline / Q000378:metabolism; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000378:metabolism*; D002417:Cattle; D002997:Clomipramine / Q000378:metabolism; D003533:Cyproheptadine / Q000378:metabolism; D007099:Imipramine / Q000378:metabolism; D007700:Kinetics; D011957:Receptors, Opioid / Q000378:metabolism*; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu
D000929:Antidepressive Agents, Tricyclic; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D000639:Amitriptyline; D003533:Cyproheptadine; D002997:Clomipramine; D007099:Imipramine
Les antidépresseurs tricycliques interagissent directement avec les sites de liaison opiacés dans la médullosurrénale bovine.