[Experimental and clinical basis for using the preparation nacom in the treatment of Itsenko-Cushing disease].
The paper is concerned with the results of an experimental study of the nacom (NC) effect on the activity of the hypothalamohypophysioadrenal system and the results of its application to 29 patients with Icenko-Cushing's disease with curative purposes. In rats the concentration of corticotropin and aldosterone was determined with a radioimmunoassay, that of corticosterone with a competitive protein binding method. The dopamine content in the hypothalamus and cerebral cortex was studied by fluorimetry. To define the hypothalamohyphysioadrenal system in the patients a study was made of blood corticotropin, cortisol and aldosterone basal levels as well as response of the system to insulin hypoglycemia induced stress. Dopaminergic NC was shown to be dose-related with the activity of the hypothalamohypophysioadrenal system. The NC effect was associated with an increase in the dopamine level in the hypothalamus and cerebral cortex. Clinical investigations proved NC efficacy for therapy of Icenko-Cushing's disease permitting one to recommend it as a pathogenetic agent for therapy of this disease.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000450:Aldosterone / Q000097:blood; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002230:Carbidopa / Q000494:pharmacology / Q000627:therapeutic use*; D003480:Cushing Syndrome / Q000188:drug therapy*; D004298:Dopamine / Q000032:analysis; D004338:Drug Combinations / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007980:Levodopa / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D002230:Carbidopa; D004298:Dopamine; D006854:Hydrocortisone
Eksperimental'no-klinicheskoe obosnovanie primeneniia preparata nakon dlia lecheniia bolezni Itsenko-Kushinga.