Possible involvement of beta 2-adrenoceptors in hyperthermic effect of l-ephedrine in rats.
The experiments were conducted in order to examine the mechanism of hyperthermia induced by l-ephedrine in rats. beta-Adrenoceptor agonists have been known to enhance normal body temperature. Therefore, the effect of various beta-adrenoceptor agonists on body temperature in rats was examined to clarify the mechanism of action of l-ephedrine. The results showed that drugs with beta 2-adrenoceptor agonist activity and l-ephedrine caused hyperthermia in rats and this effect was selectively inhibited by pretreatment of animals with propranolol (a mixed beta-adrenoceptor antagonist) or butoxamine (a selective beta 2-adrenoceptor antagonist). These results suggest that hyperthermic action of l-ephedrine may largely be due to its effect on beta-adrenoceptors.
D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects; D002078:Butoxamine / Q000494:pharmacology; D004809:Ephedrine / Q000494:pharmacology*; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D013726:Terbutaline / Q000494:pharmacology; D013997:Time Factors
D011943:Receptors, Adrenergic, beta; D002078:Butoxamine; D011433:Propranolol; D004809:Ephedrine; D013726:Terbutaline; D000420:Albuterol