A double-blind comparative trial of nedocromil sodium and placebo in the management of bronchial asthma in patients routinely using oral bronchodilators.
The efficacy and tolerability of nedocromil sodium, 4 mg four times daily, were investigated in a 4-week, randomized, placebo-controlled, double-blind trial in 54 asthmatic patients. Significant improvements were seen in the nedocromil sodium treated patients with respect to asthma severity (recorded by patients on diary cards); lung function (assessed by PEFR); daytime and night-time asthma (patients' diary cards), and morning and evening peak flow rates (measured by patients at home). Unusual symptoms were few and of a minor nature, differing little between active and placebo treatment. Nedocromil sodium, at the dosage used in this study, was well tolerated and provided a useful addition to asthma therapy.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002940:Circadian Rhythm; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017835:Nedocromil; D011804:Quinolines / Q000627:therapeutic use*
D001993:Bronchodilator Agents; D011804:Quinolines; D017835:Nedocromil