[Interaction of growth factors and oncogenes in the tumorous transformation of cells].
Different aspects of the interaction of polypeptide growth factors with their receptors are reviewed. The problem of structural and functional interactions of the normal and transforming growth factors as well as the protein products of oncogenes during transmittance of a mitogenic signal and the proliferation regulation of normal and tumour cells is discussed.
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002472:Cell Transformation, Viral / Q000187:drug effects; D002478:Cells, Cultured; D004273:DNA, Neoplasm / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D004347:Drug Interactions; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D005814:Genes, Viral / Q000187:drug effects; D006133:Growth Substances / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009857:Oncogenes / Q000187:drug effects*; D009858:Oncogenic Viruses / Q000235:genetics / Q000472:pathogenicity; D010455:Peptides / Q000494:pharmacology; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D014176:Protein Biosynthesis / Q000187:drug effects; D011956:Receptors, Cell Surface / Q000187:drug effects; D015291:Transforming Growth Factors; D014178:Translocation, Genetic / Q000187:drug effects
D004273:DNA, Neoplasm; D004279:DNA, Viral; D006133:Growth Substances; D010455:Peptides; D010982:Platelet-Derived Growth Factor; D011956:Receptors, Cell Surface; D004815:Epidermal Growth Factor; D015291:Transforming Growth Factors
Vzaimodeĭstvie faktorov rosta i inkogenov pri opukholevoĭ transformatsii kletok.