Pharmacology of free radical scavenging in inflammation.
Current available evidence suggesting a role for oxygen free radicals in inflammatory processes is reviewed. The effects of NSAID as scavengers or inhibitors of superoxide anion generation are described. The anti-inflammatory effect of the superoxide dismutase drug version named Orgotein is discussed in relation to its enzymic activity and pharmacokinetics profile.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002417:Cattle; D005609:Free Radicals; D007109:Immunity / Q000187:drug effects; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism / Q000494:pharmacology; D008667:Metalloproteins / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D010084:Oxidation-Reduction; D011817:Rabbits; D051381:Rats; D013481:Superoxides / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D005609:Free Radicals; D008054:Lipid Peroxides; D008667:Metalloproteins; D013481:Superoxides; C005180:orgotein