Steroid receptor activation: the glucocorticoid receptor as a model system.
The glucocorticoid receptor has been used as a model for steroid receptor activation. Because of recent evidence for the essentially nuclear location of the unoccupied receptors of 1,25-dihydroxycholecalciferol and 17 beta-estradiol, the significance of the activation mechanism converting unactivated receptor complexes to DNA-binding forms is unclear for some receptors. Up to now the weight of evidence favors a cytoplasmic location of the unactivated glucocorticoid receptor. In this article we describe studies on the nature of the activation mechanism and of regulatory factors.
D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D008954:Models, Biological; D008970:Molecular Weight; D011494:Protein Kinases / Q000378:metabolism; D018167:Receptors, Calcitriol; D011959:Receptors, Estradiol / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000502:physiology*; D011987:Receptors, Steroid / Q000378:metabolism
D018167:Receptors, Calcitriol; D011959:Receptors, Estradiol; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D004247:DNA; D011494:Protein Kinases