[Cyclic GMP- and AMP-modified calcium binding by the myocardial sarcolemma in circulatory hypoxia].
10(-6) M cAMP were shown to induce a 61% and 21% increase in 45Ca binding to sarcolemma proteins in intact and injured (circulatory hypoxia) hearts, respectively. The addition of exogenous protein kinase equalized 45Ca-binding levels in normal and impaired sarcolemma. The decrease in 45Ca-binding capacity by 16 and 36% was detected in the presence of 10(-7) and 10(-6) M of cGMP, respectively. In impaired hearts, cAMP and Ca-ATPase activity levels remain constant, while cGMP content increases, as compared to normal myocardial level.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism* / Q000494:pharmacology; D006152:Cyclic GMP / Q000378:metabolism* / Q000494:pharmacology; D004285:Dogs; D000860:Hypoxia / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D011494:Protein Kinases / Q000494:pharmacology; D012508:Sarcolemma / Q000378:metabolism*
D000242:Cyclic AMP; D011494:Protein Kinases; D000252:Calcium-Transporting ATPases; D006152:Cyclic GMP; D002118:Calcium
Moduliruemoe tsiklicheskimi GMF i AMF sviazyvanie kal'tsiia sarkolemmoĭ miokarda pri tsirkuliatornoĭ gipoksii.