Immune response in sows given transmissible gastroenteritis virus or canine coronavirus.
Twelve pregnant sows were inoculated oral-nasally 8 weeks before farrowing with attenuated transmissible gastroenteritis virus (TGEV), tissue culture-adapted canine coronavirus (CCV), or fluids from mock-infected culture (controls). A 2nd dose of the same inoculum, one-half oral-nasally and one-half intramammarily, was given 6 weeks later. Neutralizing antibodies for TGEV and CCV were demonstrated in sera, colostrum, and milk whey from the virus-vaccinated sows. Homologous geometric mean neutralizing titers were generally 4-fold higher than were heterologous titers. After challenge exposure of the nursing pigs with virulent TGEV, average morbidity and mortality for the pigs were 81% and 34% (mortality range = 11% to 63%), respectively, in the TGEV-vaccinated group; 83% and 39% (mortality range = 15% to 83%), respectively, in the CCV-vaccinated group; and 97% and 84% (mortality range = 78% to 100%), respectively, in the controls. Seemingly, sera from swine exposed to CCV could test serologically positive for TGEV-neutralizing antibody, and TGEV and CCV share at least 1 common neutralizing determinant that may be involved in protection.
D000828:Animal Population Groups / Q000276:immunology*; D000818:Animals; D000833:Animals, Suckling / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D000917:Antibody Formation; D000956:Antigens, Viral / Q000276:immunology*; D003332:Coronaviridae / Q000276:immunology*; D004285:Dogs; D005260:Female; D011247:Pregnancy; D013552:Swine / Q000276:immunology*; D005760:Transmissible gastroenteritis virus / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary*
D000914:Antibodies, Viral; D000956:Antigens, Viral