Comparative antidotal effects of diethyldithiocarbamate, dimercaptosuccinate, and diethylenetriaminepentaacetate against cadmium-induced testicular toxicity in mice.
The compounds diethyldithiocarbamate (DDTC, Dithiocarb), 2,3-dimercaptosuccinic acid (DMSA), and diethylenetriaminepentaacetic acid (DTPA) were evaluated for effectiveness in protecting mouse testes following administration of an LD100 dose of CdCl2 X 2.5 H2O (Cd). Toxicologic responses were assessed by light microscopic techniques. DTPA gave the most effective testicular protection of the three compounds when given within 30 minutes prior to Cd, but only DDTC was effective when given 30 minutes or longer after Cd. Degenerative changes were minimal when DDTC was given as late as three hours after Cd, and were mild following a four-hour interval. However, the changes were marked, but less severe than in mice receiving Cd only, when DDTC was administered five hours after Cd.
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D004050:Ditiocarb / Q000494:pharmacology*; D004822:Epididymis / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D004369:Pentetic Acid / Q000494:pharmacology*; D012671:Seminiferous Tubules / Q000187:drug effects / Q000473:pathology; D004113:Succimer / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013859:Thiocarbamates / Q000494:pharmacology*; D013997:Time Factors
D013438:Sulfhydryl Compounds; D013859:Thiocarbamates; D002104:Cadmium; D004369:Pentetic Acid; D004050:Ditiocarb; D004113:Succimer