title: [Leukocyte interferon reaction in patients with primary immunodeficiencies].
abstract: The capacity of leukocytes from children with primary immunodeficiency to produce alpha- and gamma-interferons in vitro was studied. Interferon response of leukocytes in most of the patients examined was found to be practically unchanged. The immunostimulating therapy in some cases exerted a regulating effect on leukocyte capacity for interferon production. It is assumed that the interferon-producing function of T lymphocytes may be preserved in patients suffering from primary immunodeficiency.
mesh_terms: D000293:Adolescent; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D004686:Encephalomyocarditis virus; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000276:immunology* / Q000628:therapy; D007167:Immunotherapy; D007370:Interferon Type I / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000096:biosynthesis; D008297:Male; D009522:Newcastle disease virus; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007370:Interferon Type I; D007371:Interferon-gamma
vernacular_title: Interferonovaia reaktsiia leĭkotsitov u bol'nykh s pervichnymi immunodefitsitami.