Independent regulation of the antiviral states induced by MuIFN-alpha/beta and by MuIFN-gamma.
The stability profiles of the antiviral states induced in L-929 cells against mengovirus by murine interferons MuIFN-alpha/beta and by MuIFN-gamma were shown to be different. Treatment of cells with combinations of IFN-alpha/beta and IFN-gamma have previously been shown to result in a potentiated expression of the antiviral state. Here we report studies of the stabilities of the antiviral states induced by various combinations of IFN-alpha/beta and IFN-gamma and that the regulation of the antiviral states induced by IFN-alpha/beta and IFN-gamma were independent of each other.
D000818:Animals; D004347:Drug Interactions; D007370:Interferon Type I / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D007739:L Cells; D008574:Mengovirus / Q000254:growth & development; D051379:Mice
D007370:Interferon Type I; D007371:Interferon-gamma