title: Effects of neonatal undernutrition and subsequent nutritional rehabilitation or administration of thyroxine and hydrocortisone on the inositol phosphatase activities in rat intestine.
abstract: Undernutrition during the suckling period imposed by maternal protein deficiency during lactation resulted in elevated inositol triphosphatase activity (units per gram of wet tissue) in the ileum and lower phytase activity in the duodenum and jejunum. Activities of inositol triphosphatase in the duodenum and jejunum and phytase in ileum were unaffected. Postweaning nutritional rehabilitation resulted in elevated specific activities of both enzymes in all segments; however, activities of whole segments were similar to the corresponding control values. Elevation of inositol triphosphatase (ileum) and decline of phytase (duodenum and jejunum) activities due to undernutrition were reversed by the administration of hydrocortisone or thyroxine during undernutrition. These results suggest that maturation of activities of inositol triphosphatase in ileum (by hydrocortisone) and phytase in all segments (by both hydrocortisone and thyroxine) is under hormonal regulation, and the effects of neonatal undernutrition may be partly due to hormonal imbalances.
mesh_terms: D010832:6-Phytase / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D001835:Body Weight; D004247:DNA / Q000032:analysis; D006854:Hydrocortisone / Q000494:pharmacology*; D007421:Intestine, Small / Q000032:analysis / Q000201:enzymology* / Q000473:pathology; D009929:Organ Size; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D011502:Protein-Energy Malnutrition / Q000201:enzymology* / Q000473:pathology / Q000628:therapy; D011506:Proteins / Q000032:analysis; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology*; D000099182:Phosphoinositide 5-Phosphatases
chemical_list: D010832:6-Phytase; D004247:DNA; D006854:Hydrocortisone; D010744:Phosphoric Monoester Hydrolases; D011506:Proteins; D013974:Thyroxine; D000099182:Phosphoinositide 5-Phosphatases