Incorporation of carbocyclic (E)-5-(2-iodovinyl)-2'-deoxyuridine (C-IVDU) into DNA of herpes simplex virus-infected cells.
C-IVDU, the carbocyclic analogue of IVDU [(E)-5-(2-iodovinyl)-2'-deoxyuridine], in which the sugar moiety is replaced by a cyclopentane ring, is, like its parent compound, a very potent and selective inhibitor of herpes simplex virus type 1 (HSV-1) replication. Both C-IVDU and IVDU are effectively phosphorylated by HSV-1 infected cells and incorporated into viral and cellular DNA of these cells.
D000818:Animals; D002460:Cell Line; D002499:Centrifugation, Density Gradient; D002855:Chromatography, Thin Layer; D003517:Cyclopentanes / Q000378:metabolism* / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis*; D004279:DNA, Viral / Q000032:analysis / Q000096:biosynthesis*; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D010766:Phosphorylation; D018139:Simplexvirus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*
D003517:Cyclopentanes; D004279:DNA, Viral; D004247:DNA; C045201:1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-5-(2-iodovinyl)-2,4-(1H,3H)-pyrimidinedione; D003857:Deoxyuridine