Persistence, latency and reactivation of Japanese encephalitis virus infection in mice.
Persistent and latent Japanese encephalitis virus (JEV) infection was studied in pregnant and non-pregnant mice. Following intraperitoneal inoculation into pregnant mice JEV persisted for 16 weeks in contrast to 4 weeks in non-pregnant mice. This was followed by a higher frequency of latent infection in pregnant mice. The virus could be reactivated during pregnancy or by cyclophosphamide treatment, the latter being more effective.
D000818:Animals; D000917:Antibody Formation; D004664:Encephalitis Virus, Japanese / Q000302:isolation & purification / Q000472:pathogenicity*; D004672:Encephalitis, Japanese / Q000276:immunology / Q000382:microbiology*; D005260:Female; D051379:Mice; D009928:Organ Specificity; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*; D011270:Pregnancy, Animal; D013997:Time Factors