Glycyrrhetic acid inhibits tumor-promoting activity of teleocidin and 12-O-tetradecanoylphorbol-13-acetate in two-stage mouse skin carcinogenesis.
Glycyrrhetic acid suppressed tumor promoter-induced effects in vitro, such as stimulation of 32Pi-incorporation into phospholipids of cultured cells and down-regulation of the epidermal growth factor receptor. Glycyrrhetic acid inhibited the promoting activity of both 12-O-tetradecanoylphorbol-13-acetate (TPA) and teleocidin on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene (DMBA). The percentage of tumor-bearing mice in the group treated with DMBA plus teleocidin was 88% at week 18, whereas that in the group treated with DMBA plus teleocidin and glycyrrhetic acid (10 mumol/painting) was 6%. Similarly, the percentage of tumor-bearing mice of the group treated with DMBA plus TPA was 97% at week 20, whereas that of the group treated with DMBA plus TPA and glycyrrhetic acid was 40%. Therefore, glycyrrhetic acid was proved to inhibit the activity of two different tumor promoters, teleocidin and TPA, in mouse skin.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D066246:ErbB Receptors; D005260:Female; D006034:Glycyrrhetinic Acid / Q000494:pharmacology*; D006367:HeLa Cells / Q000378:metabolism; D008235:Lyngbya Toxins / Q000633:toxicity*; D051379:Mice; D008813:Mice, Inbred ICR; D010704:Phorbols; D010743:Phospholipids / Q000378:metabolism; D010761:Phosphorus Radioisotopes; D011794:Quercetin / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000032:analysis; D012878:Skin Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D013449:Sulfonamides / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate; D013997:Time Factors
D008235:Lyngbya Toxins; D010704:Phorbols; D010743:Phospholipids; D010761:Phosphorus Radioisotopes; D011956:Receptors, Cell Surface; D013449:Sulfonamides; C022176:teleocidins; D015127:9,10-Dimethyl-1,2-benzanthracene; C017967:W 7; D011794:Quercetin; D066246:ErbB Receptors; D013755:Tetradecanoylphorbol Acetate; D006034:Glycyrrhetinic Acid