Linkage between the loci for cystic fibrosis and paraoxonase.
In a material of 22 Danish, 26 Canadian, 10 Australian, 5 English and 5 American families with at least 2 children affected with cystic fibrosis (CF) a combined positive LOD score of 3.46 was found for the relationship cystic fibrosis-paraoxonase (PON) at recombination fraction theta = 0.07 in males and theta = 0.13 in females. Assuming a three allele model for PON the LOD score was 4.50 at the same recombination fractions. This confirms our earlier finding of an indication of CF-PON synteny.
D000483:Alleles; D043303:Aryldialkylphosphatase; D003550:Cystic Fibrosis / Q000201:enzymology / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*
D005819:Genetic Markers; D010744:Phosphoric Monoester Hydrolases; D043303:Aryldialkylphosphatase