[Mechanisms of the effects of Ca2+ ions on lipid peroxidation].
Mechanisms underlying Ca2+ effects on lipid peroxidation (LPO) induced in liposomes (from egg yolk lecithin) and UFsomes (from linolenic acid, methyl linolenate) with the aid of O2- -system (Fe2+ + ascorbate) were studied. It was shown that stimulation of lipid peroxidation by low Ca2+ concentrations (10(-6)-10(-5) M) was due to its ability to release Fe2+-ions bound to negatively charged (phosphate, carboxylic) lipid groups (of licethin, linolenic acid), thus increasing the concentration of catalytically active Fe2+. The inhibitory effect of high Ca2+ concentrations was caused by its interaction with superoxide anion-radicals and was not observed in LPO-systems, independent of O2- generation (e. g. Fe2+ + cumol hydroperoxide).
D002118:Calcium / Q000494:pharmacology*; D005609:Free Radicals; D066298:In Vitro Techniques; D007700:Kinetics; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism
D005609:Free Radicals; D008054:Lipid Peroxides; D013481:Superoxides; D002118:Calcium
Mekhanizmy deĭstviia ionov Ca2+ na protsess perekisnogo okisleniia lipidov.