Hypertension and atherosclerosis in cholesterol-fed rabbits. Part 1. Mild, two-kidney, one-clip Goldblatt hypertension treated with enalapril.
Ten groups of New Zealand white rabbits were used to study the effects of mild, chronic two-kidney, one-clip hypertension (HT) and long-term antihypertensive therapy on atherogenesis. Five groups were fed a normal diet (ND) over the 8-month study period; 2 groups, one of which was given enalapril, remained normotensive (NT) throughout the study. Of the 3 HT groups, one was hypertensive for 7 months; the blood pressures of the other groups were normalized after 2 months with enalapril, or by removal of the clipped kidney. The other 5 groups were similar except that they were fed at 0.1% cholesterol diet (CD). The results showed that: neither mild chronic HT nor abrupt, short-term HT exacerbated atherogenesis in the CD-animals; although fibromuscular vascular lesions were present in the aorta of normal-diet, HT animals no atheroma was observed; enalapril therapy had no effect on atherogenesis; enalapril therapy reduced the total weight and the cholesterol and triglyceride content of the aorta of the ND groups regardless of blood pressure history; the aortic triglyceride content, but not the cholesterol content, of the CD group, was reduced by enalapril; and although heart size was unaffected by either diet or blood pressure levels, the mitochondria volume per unit volume of the left ventricle was reduced in both NT-ND and HT-CD groups treated with enalapril.
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004656:Enalapril / Q000627:therapeutic use*; D006978:Hypertension, Renovascular / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008854:Microscopy, Electron; D009206:Myocardium / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D011817:Rabbits; D012083:Renin / Q000378:metabolism
D002791:Cholesterol, Dietary; D008074:Lipoproteins; D004656:Enalapril; D012083:Renin