title: High thresholds for movement perception in schizophrenia may indicate abnormal extraneous noise levels of central vestibular activity.
abstract: A theoretical argument proposes that thresholds for visual perception of movement should be abnormally high in schizophrenia. This may reflect a central vestibular dysfunction, consisting of abnormally high levels of extraneous noise within the neural activity of the central vestibulo-cerebellar complex. Two experiments are reported with results that support the hypothesis. To some extent, the disorder may explain the smooth pursuit eye movement dysfunction in schizophrenia. Relations to the dopamine hypothesis in schizophrenia are discussed.
mesh_terms: D002531:Cerebellum / Q000503:physiopathology*; D004298:Dopamine / Q000502:physiology; D004585:Electrooculography; D005260:Female; D006801:Humans; D008297:Male; D009039:Motion Perception / Q000502:physiology*; D009434:Neural Pathways / Q000503:physiopathology; D011698:Pursuit, Smooth; D012559:Schizophrenia / Q000503:physiopathology*; D012684:Sensory Thresholds; D009435:Synaptic Transmission; D014726:Vestibular Nuclei / Q000503:physiopathology*
chemical_list: D004298:Dopamine