Effect of Bordetella pertussis vaccine on bleeding time, whole blood coagulation time and platelet aggregation in animals.
Bordetella pertussis vaccine, a hypoglycemic agent significantly prolonged the bleeding time and whole blood coaguistion time in rabbits and dogs when administered intraperitonially. The vaccine also affects platelet aggregation in rats 4 days after its intraperitonial administration. The effect on platelet aggregation is thought to be due to its beta adrenargic receptor blocking action which may also contribute to the hypoglycemia.
D000818:Animals; D001760:Bleeding Time; D001780:Blood Coagulation Tests; D004285:Dogs; D005260:Female; D008297:Male; D010567:Pertussis Vaccine / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010979:Platelet Function Tests; D011817:Rabbits; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D014914:Whole Blood Coagulation Time
D010567:Pertussis Vaccine; D011943:Receptors, Adrenergic, beta