Chromosomal sites for Marek's disease virus DNA in two chicken lymphoblastoid cell lines MDCC-MSB1 and MDCC-RP1.
In situ hybridization of viral DNA fragments to metaphase chromosomes of two chicken T-lymphoblastoid cell lines (MDCC) demonstrated that Marek's disease virus DNA was located in the short arm of chromosome 2 of MDCC-MSB1 and MDCC-RP1 cells and in the short arm of chromosome 4 of MDCC-MSB1 cells. The MDV DNA sequences in these chromosomes are not in the vicinity of oncogenes or integrated retroviruses that have been previously identified in chicken chromosomes.
D000818:Animals; D002460:Cell Line; D002645:Chickens / Q000235:genetics*; D002874:Chromosome Mapping; D002875:Chromosomes / Q000648:ultrastructure; D004279:DNA, Viral / Q000235:genetics*; D008381:Herpesvirus 2, Gallid / Q000235:genetics*; D009693:Nucleic Acid Hybridization
D004279:DNA, Viral