title: Phencyclidine-induced stereotyped behaviors after injection of ethylketocyclazocine, Mr 2266 and naltrexone in rats.
abstract: The effects of ethylketocyclazocine (EKC), Mr 2266 and naltrexone on the stereotyped behaviors induced by an intraperitoneal injection of phencyclidine (PCP) were examined. PCP-induced turning, backpedalling, head weaving and sniffing were antagonized by pretreatment with EKC (0.25-4.0 mg/kg). While pretreatment with Mr 2266 (2.5 mg/kg), a kappa selective antagonist, and naltrexone (10 mg/kg), a mu selective antagonist, failed to affect the PCP-induced stereotypy, Mr 2266 antagonized the suppressing effect of EKC on PCP-induced stereotypy. Taken into consideration, this suggests that kappa opioid agonists such as EKC antagonize PCP-induced stereotyped behaviors through a kappa opioid mechanism, and that the mu opioid receptor may not play an important role in the PCP-induced stereotypy in rats.
mesh_terms: D000818:Animals; D001575:Benzomorphans / Q000008:administration & dosage; D003496:Cyclazocine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004347:Drug Interactions; D016314:Ethylketocyclazocine; D008297:Male; D009048:Motor Skills / Q000187:drug effects; D009271:Naltrexone / Q000008:administration & dosage*; D010622:Phencyclidine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects*
chemical_list: D001575:Benzomorphans; D011957:Receptors, Opioid; C027247:MR 2266; D016314:Ethylketocyclazocine; D009271:Naltrexone; D010622:Phencyclidine; D003496:Cyclazocine