[Vitamin D deficiency rickets: single-dose therapy versus continuous therapy].
This is a comparative study of massive single dose treatment (400 000 I. U. vitamin D3, divided in 2 X 200 000 I. U. on day 1 and day 3, orally) versus continuous treatment (9600 I. U. vitamin D3-drops for 18 days) of vitamin D-deficiency rickets (VDR). To estimate the effectiveness of these two kinds of treatment the serum concentrations of calcium (Ca), phosphorus (P), alkaline phosphatase (aP), calcitriol (25-OH-CC), parathyroid hormone (PTH) and calcitonin (Ct) before and during treatment (on day 3, 7, 14, 21) were studied in 10 patients, 5 in each group, with VDR. There was no difference in the course of serum concentrations of Ca, P and aP in these two treatment-groups. The elevated PTH returned more quickly to normal range in the single dose study group. Ct-serum concentrations showed too different courses in the studied patients, therefore no comparison could be made. 25-OH-CC showed a very quick increase in the single dose-group and a slower one in the continuous treatment group the climax in both groups reached a value far over the tentative range. According to these results an unequivocal better effect of one of these two compared VDR-treatments could not be seen, what means that both treatments can be recommended.
D000469:Alkaline Phosphatase / Q000097:blood; D002112:Calcifediol / Q000097:blood; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000097:blood; D002762:Cholecalciferol / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D012279:Rickets / Q000188:drug therapy* / Q000201:enzymology; D014808:Vitamin D Deficiency / Q000188:drug therapy* / Q000201:enzymology
D010281:Parathyroid Hormone; D010710:Phosphates; D002762:Cholecalciferol; D002116:Calcitonin; D000469:Alkaline Phosphatase; D002112:Calcifediol; D002118:Calcium
Vitamin-D-Mangelrachitis: Stosstherapie versus kontinuierliche Therapie.