title: Corticotropin-releasing factor receptors: autoradiographic identification.
abstract: Our studies on CRF receptors confirm the established role of CRF in regulating pituitary hormone secretion and support a physiological role for endogenous CRF in regulating CNS activity. Studies to characterize CRF receptors and CRF-containing pathways in the brain provide a means for understanding the various functions of this neuropeptide in different areas of the CNS. Finally, the ability to identify and localize CRF receptors in postmorten human tissue provides a basis for studying the role of CRF in the etiology and pathophysiology of a variety of endocrine, neurological, and psychiatric disorders.
mesh_terms: D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism* / Q000502:physiology / Q000031:analogs & derivatives; D006801:Humans; D008253:Macaca mulatta; D009434:Neural Pathways / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018019:Receptors, Corticotropin-Releasing Hormone; D009435:Synaptic Transmission
chemical_list: D011956:Receptors, Cell Surface; D018019:Receptors, Corticotropin-Releasing Hormone; C041241:corticotropin-releasing hormone, Nle(21)-iodo-Tyr(32)-; D003346:Corticotropin-Releasing Hormone