[Adult T-cell lymphoma/leukemia associated with HTLV-I virus in Martinique: apropos of 2 cases].
Two HTLV-I associated adult T cell leukemia cases were observed in patient from Martinique (French West Indies). These case are similar to the clinical entity, described by Takatsuki in 1977 in Japan and by Catovsky in Caribbean patients, characterized by a lymphadenopathy, skin lesions and visceral involvement, hypercalcemia, an aggressive course, and poor prognosis. The malignant cells with T4 phenotype and often suppressive function, were pleomorphic, mature, with prominent nuclear irregularities. Systematic research of HTLV-I virus or antibodies in patients with this clinical picture, to measure the influence of this virus in T cell lymphoproliferative diseases in France and in French West Indies is required.
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000302:isolation & purification*; D001853:Bone Marrow / Q000473:pathology; D017977:Deltaretrovirus / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007938:Leukemia / Q000276:immunology / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D012867:Skin / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000648:ultrastructure*
D000914:Antibodies, Viral
Leucémie/lymphome T de l'adulte associé au virus HTLV-I en Martinique: a propos de deux cas.