[Familial type of hypophyseal nanism. Apropos of 7 families in western Algeria].
Eighteen pituitary dwarfs belonging to 7 different West Algerian families were studied. Eleven patients from 4 families presented isolated growth hormone deficiency, 7 patients from 3 families had multiple pituitary hormone deficiencies. Serum GH levels before and after standard pharmacological stimulations were below 2 ng/ml in all cases. Three of 10 hGH treated patients increased significantly their growth rate (8.5 +/- 0.5 cm/year) during the first year of treatment; growth was moderate (5.3 +/- 0.8 cm/year) in 3 patients and poor (4.5 cm/year) in 2 patients. In 2 cases the follow-up is insufficient.
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D000328:Adult; D000365:Age Determination by Skeleton; D002648:Child; D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D003241:Consanguinity; D004393:Dwarfism, Pituitary / Q000097:blood / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000627:therapeutic use; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D008297:Male; D010375:Pedigree; D013972:Thyrotropin / Q000627:therapeutic use
D006063:Chorionic Gonadotropin; D012739:Gonadal Steroid Hormones; D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin; D013006:Growth Hormone
Nanismes hypophysaires de types familiaux. A propos de 7 familles en Algérie Ouest.