A rare case of Aicardi syndrome with severe brain malformation and hepatoblastoma.
A 2-month-old Japanese girl exhibited tonic seizure, agenesis of the corpus callosum, lacunar chorioretinopathy, vertebral anomalies, electroencephalographic abnormalities and a malignant tumor. Autopsy revealed a hepatoblastoma and severe brain malformations consisting of callosal agenesis, arhinencephaly, marked polymicrogyria and optic nerve anomalies. It was thought that the pathogenic factor in this case may exert its effect during the fourth or fifth week of intrauterine life, and then may continue until the beginning of neuronal migration (about 3 months). This is the first reported case of Aicardi syndrome associated with hepatoblastoma, and may provide a link between teratogenicity and oncogenicity.
D000015:Abnormalities, Multiple; D061085:Agenesis of Corpus Callosum; D006528:Carcinoma, Hepatocellular / Q000151:congenital* / Q000473:pathology; D004569:Electroencephalography; D005124:Eye Abnormalities; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000151:congenital* / Q000473:pathology; D013131:Spine / Q000002:abnormalities*; D013577:Syndrome; D014057:Tomography, X-Ray Computed