[Synthesis of virus-specific and cellular proteins in the presence of bonafton].
Inhibition of the synthesis of virus-specific proteins of influenza A/WSN/33 virus in the cells of chick embryo fibroblasts and in continuous cells of dog embryonal kidney was discovered as was a negligible inhibition of the synthesis of cell proteins in the presence of an original synthetic antivirus drug bonaphthon. Experiments were made to attain selective inhibition of individual virus-specific proteins of influenza virus in these cultures. In model experiments in vitro in a cell-free protein-synthesizing system, bonaphthon was demonstrated to inhibit translation of RNA-virus of encephalomyocarditis on the virus template without affecting translation on the cell template of hemoglobin mRNA.
D000818:Animals; D002642:Chick Embryo; D003470:Culture Media; D004285:Dogs; D004622:Embryo, Mammalian; D004686:Encephalomyocarditis virus / Q000378:metabolism*; D005260:Female; D005347:Fibroblasts; D066298:In Vitro Techniques; D009980:Influenza A virus / Q000378:metabolism*; D007668:Kidney; D009285:Naphthoquinones / Q000494:pharmacology*; D011247:Pregnancy; D014764:Viral Proteins / Q000096:biosynthesis*
D003470:Culture Media; D009285:Naphthoquinones; D014764:Viral Proteins; C011180:bonafton
Sintez virusspetsificheskikh i kletochnykh belkov v prisutstvii bonaftona.