Studies on griseolic acid derivatives. I. Synthesis of substituted derivatives of griseolic acid at the N1, C6, C2' or C7' position and their biological activities.
Griseolic acid derivatives having a different substituent at the N1,C6,C2' or C7' position of the natural product were synthesized and their structure activity relationship to cyclic nucleotide phosphodiesterase inhibitory activity was investigated.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000201:enzymology; D007202:Indicators and Reagents; D051381:Rats; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; C046499:griseolic acid; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D000241:Adenosine