title: Human T-lymphotropic virus type III in high-risk, antibody-negative homosexual men.
abstract: A cohort of 215 asymptomatic homosexually active men from a Boston community health center are being prospectively followed to assess the natural history of the human T-lymphotropic virus type III (HTLV-III) infection. To determine if certain asymptomatic persons who are HTLV-III antibody negative may be viremic, an algorithm was developed that defined high-risk characteristics (a sexual partner with the acquired immunodeficiency syndrome [AIDS]; more than 100 homosexual partners; or leukopenia, lymphopenia, neutropenia, or thrombocytopenia). Of 33 asymptomatic homosexual men who did not have antibody to HTLV-III and whose cases have not been previously reported, 2 had HTLV-III recovered from their lymphocytes. Clinical, behavioral, and hematologic data from seronegative persons did not distinguish between those with negative or positive viral cultures. Asymptomatic carriage of HTLV-III in high-risk seronegative persons underscores the need to base preventive educational strategies and behavioral modification on the assessment of risk factors and not solely on the results of HTLV-III antibody screening.
mesh_terms: D000163:Acquired Immunodeficiency Syndrome; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D017977:Deltaretrovirus / Q000276:immunology / Q000302:isolation & purification*; D006716:Homosexuality; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012192:Retroviridae Infections / Q000453:epidemiology*; D012306:Risk; D012725:Sexual Behavior; D014766:Viremia / Q000453:epidemiology*
chemical_list: D000914:Antibodies, Viral