Cyclosporin A and rabbit mammary prolactin receptors.
The binding of cyclosporin A and ovine prolactin to rabbit mammary gland membranes was determined. CsA bound with a Kd of 2.2 X 10(-6)M whereas prolactin bound with a Kd of 2 X 10(-10)M. The binding of each ligand was an independent event and neither ligand influenced the binding of the other ligand showing that CsA does not inhibit the binding of prolactin to its specific receptor in this system.
D000818:Animals; D001667:Binding, Competitive; D002462:Cell Membrane / Q000378:metabolism; D003524:Cyclosporins / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D008321:Mammary Glands, Animal / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism; D011817:Rabbits; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism; D011981:Receptors, Prolactin
D003524:Cyclosporins; D011956:Receptors, Cell Surface; D011981:Receptors, Prolactin; D011388:Prolactin