[Participation of GABA in mediating the effects of ethanol in rats with differing susceptibility to the development of experimental alcoholism].
The influence of ethanol and of GABA receptors blocker bicuculline on recovery cycles of primary response of the sensorimotor cortex was studied in rats with strong and weak inclination to development of experimental alcoholism. It is found that in rats of the first group, inhibition in the cerebral cortex was weakened in comparison with the rats of the second group. Ethanol in non-narcotic doses intensified the inhibitory processes and its effects could be prevented or suppressed by bicuculline. The conclusion is made about GABA participation in mediation of ethanol effects on inhibitory processes in the cerebral cortex.
D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D001640:Bicuculline; D004198:Disease Susceptibility; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology; D051381:Rats; D011963:Receptors, GABA-A / Q000502:physiology; D013003:Somatosensory Cortex / Q000503:physiopathology; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline
Uchastie GAMK v oposredovanii éffektov etanola u krys s razlichnoĭ predraspolozhennost'iu k razvitiiu éksperimental'nogo alkogolizma.