The influence of the solvent on the toxicity and radioprotective effect of thiophosphate WR2721 in mice.
The influence of various solvents on the toxicity as well as the protective efficiency of thiophosphate WR2721 in X-irradiated male mice is described. The use of Sörensen buffer as solvent with a pH-value of 7.4 leads to a statistically significant lower lethality in animals than aqua bidest. However, the radiation efficacy of thiophosphate with respect to the acute lethality within 30 days after irradiation is not influenced by the choice of the solvent used. A dose reduction factor of 2.49 +/- 0.03 is gained for the LD50/30 d at 500mg WR2721 per kg animal weight.
D004999:Amifostine / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D006863:Hydrogen-Ion Concentration; D008297:Male; D051379:Mice; D009946:Organothiophosphorus Compounds / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D012997:Solvents / Q000494:pharmacology
D009946:Organothiophosphorus Compounds; D012997:Solvents; D004999:Amifostine