Brain necrosis after radiotherapy for primary intracerebral tumor.
Radiotherapy is a standard postoperative treatment for cerebral glioma. We have observed the onset of symptoms related to brain necrosis, as opposed to recurrent tumor, in surviving patients. This has been manifest as dementia with a computed tomographic pattern of low density in the frontal lobe uninvolved with tumor, but within the field of radiotherapy. Two patients presented with mass lesions also unrelated to recurrent tumor. We question the necessity of full brain irradiation and suggest that radiotherapy techniques be altered to target the tumor and not encompass the entire brain.
D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000532:radiotherapy; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D003704:Dementia / Q000209:etiology; D005260:Female; D005909:Glioblastoma / Q000532:radiotherapy; D005910:Glioma / Q000532:radiotherapy; D006801:Humans; D008875:Middle Aged; D009336:Necrosis; D009837:Oligodendroglioma / Q000532:radiotherapy; D011832:Radiation Injuries / Q000150:complications / Q000473:pathology* / Q000517:prevention & control; D014057:Tomography, X-Ray Computed