title: Effect of manganese on human placental spin-lattice (T1) and spin-spin (T2) relaxation times.
abstract: Human placentas were obtained immediately following delivery and incubated with manganese chloride (MnCl2) in concentrations ranging from 0.002 to 2.0 mM. Proton density, T1 and T2 were measured at times ranging from 5-200 minutes. There was rapid uptake of manganese by the placenta producing a dose-dependent decrease in placental T1 and T2. The major effect of manganese uptake was shortening of T1 suggesting that the contrast between placenta and myometrium will be enhanced predominantly for T1-dependent imaging pulse sequences.
mesh_terms: D002712:Chlorides; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008345:Manganese / Q000032:analysis* / Q000378:metabolism; D017895:Manganese Compounds; D009215:Myometrium / Q000378:metabolism; D010920:Placenta / Q000032:analysis* / Q000378:metabolism; D011247:Pregnancy; D011522:Protons; D013113:Spin Labels
chemical_list: D002712:Chlorides; D017895:Manganese Compounds; D011522:Protons; D013113:Spin Labels; D008345:Manganese; C025340:manganese chloride