title: Biosynthesis of superoxide dismutase in Saccharomyces cerevisiae: effects of paraquat and copper.
abstract: Growth of Saccharomyces cerevisiae in the presence of paraquat caused an increase the intracellular flux of superoxide radicals and in superoxide dismutase biosynthesis. The addition of copper to the growth medium also elicited an increase in superoxide dismutase levels. A cytochrome c deficient mutant strain was found to be more responsive than the wild type strain to paraquat and/or copper by increasing its copper-zinc superoxide dismutase. Catalase activity in both strains was not significantly affected by paraquat and/or copper.
mesh_terms: D002374:Catalase / Q000096:biosynthesis; D003300:Copper / Q000494:pharmacology*; D005609:Free Radicals; D007700:Kinetics; D010101:Oxygen Consumption / Q000187:drug effects; D010269:Paraquat / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000096:biosynthesis*; D013481:Superoxides / Q000378:metabolism
chemical_list: D005609:Free Radicals; D013481:Superoxides; D003300:Copper; D002374:Catalase; D013482:Superoxide Dismutase; D010269:Paraquat