Structure of the human interleukin-2 receptor gene.
The gene encoding the human interleukin-2 (IL-2) receptor consists of 8 exons spanning more than 25 kilobases on chromosome 10. Exons 2 and 4 were derived from a gene duplication event and unexpectedly also are homologous to the recognition domain of human complement factor B. Alternative messenger RNA (mRNA) splicing may delete exon 4 sequences, resulting in a mRNA that does not encode a functional IL-2 receptor. Leukemic T cells infected with HTLV-I and normal activated T cells express IL-2 receptors with identical deduced protein sequences. Receptor gene transcription is initiated at two principal sites in normal activated T cells. Adult T cell leukemia cells infected with HTLV-I show activity at both of these sites, but also at a third transcription initiation site.
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D011415:Complement Factor B / Q000235:genetics; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004274:DNA, Recombinant / Q000302:isolation & purification; D017977:Deltaretrovirus; D005802:Genes, MHC Class II; D006801:Humans; D010442:Peptide Chain Initiation, Translational; D012333:RNA, Messenger / Q000235:genetics; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000235:genetics*; D015375:Receptors, Interleukin-2; D012091:Repetitive Sequences, Nucleic Acid; D012192:Retroviridae Infections / Q000235:genetics; D013601:T-Lymphocytes / Q000382:microbiology; D014158:Transcription, Genetic
D004274:DNA, Recombinant; D012333:RNA, Messenger; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D004247:DNA; D011415:Complement Factor B