title: [Enzymes of adenosine metabolism in lymphocytes and the functional state of the sympatho-adrenal system in tumor processes].
abstract: A correlation between reactions of the sympathoadrenal system and the activity of adenosine transformation enzymes in lymphocytes is demonstrated in the dynamics of metastatic Lewis carcinoma development in C57Bl mice. In the period when metastases arise a decrease in the adenosine deaminase activity in lymphoid cells of the thymus and spleen is accompanied by drop in the content of DOPA, noradrenalin and adrenalin in adrenals. At the late stages of the tumour process a decrease in the amount of these compounds in adrenals is accompanied by the diminution of the adenosine deaminase activity and by an increase in the 5'-nucleotidase activity in the thymus. Contrary changes are observed in spleen lymphocytes. The revealed disturbances may stimulate to a considerable extent the appearance and growth of metastases.
mesh_terms: D015720:5'-Nucleotidase; D000241:Adenosine / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000378:metabolism; D000311:Adrenal Glands / Q000503:physiopathology*; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D007031:Hypothalamus / Q000503:physiopathology; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology*; D009708:Nucleotidases / Q000378:metabolism; D013154:Spleen / Q000201:enzymology; D013950:Thymus Gland / Q000201:enzymology
chemical_list: D002395:Catecholamines; D009708:Nucleotidases; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase; D000241:Adenosine
vernacular_title: Fermenty metabolizma adenozina v limfotsitakh i funktsional'noe sostoianie simpatoadrenalovoĭ sistemy pri opukholevom protsesse.