Reactor production and detection of radiolabeled cis-platinum.
Small quantities of radiolabeled cis-platinum were prepared by two methods. The thermal neutron irradiation of potassium tetrachloroplatinite followed by radiochemical synthesis was compared to the direct irradiation of the cis-platinum itself. Both methods produced usable quantities of tracer, but the direct method proved most practical. Radiochemical purification and analysis data are also presented. Liquid scintillation and NaI(Tl) counting techniques were evaluated. Counting the numerous x-rays produced from several platinum radioisotopes in a well-type NaI(Tl) detector proved most convenient for routine use. It is concluded that these methods provide a useful route for the preparation, analysis and determination of measurable quantities of radiolabeled cis-platinum for small scale applications.
D002945:Cisplatin / Q000032:analysis / Q000138:chemical synthesis; D007553:Isotope Labeling / Q000379:methods*; D009688:Nuclear Reactors; D010984:Platinum; D011854:Radiochemistry; D011868:Radioisotopes; D011874:Radiometry
D011868:Radioisotopes; D010984:Platinum; D002945:Cisplatin