Cyclic AMP-dependent protein phosphorylation is reduced in rat striatum after chronic ethanol treatment.
Endogenous protein phosphorylation by cyclic AMP-dependent protein kinase was found reduced in striatal membranes obtained from chronic ethanol-treated rats. Experiments using an exogenous substrate show that the decreased response is due to a deficiency in the phosphorylating activity of the cyclic AMP-dependent protein kinase and not to a lack of endogenous substrate for phosphorylation.
D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D002421:Caudate Nucleus / Q000378:metabolism*; D000242:Cyclic AMP / Q000502:physiology; D004298:Dopamine / Q000378:metabolism; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D009419:Nerve Tissue Proteins; D000242:Cyclic AMP; D011494:Protein Kinases; D004298:Dopamine