Transfer of reactivity with in vitro produced transfer factor in rhesus and owl monkeys.
Transfer factors against two heterologous antigens, Herpesvirus saimiri and owl monkey kidney cells, were replicated in vitro in a human lymphoblastoid cell line (LDV/7) and injected into rhesus and owl monkeys. Transfer of immunity was demonstrated by the leukocyte migration inhibition assay. This study suggests that heterologous transfer factor, replicated in vitro, can transfer cellular immunity against membrane antigens in rhesus and owl monkeys.
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D001029:Aotus trivirgatus; D002460:Cell Line; D002464:Cell Migration Inhibition; D006566:Herpesviridae Infections / Q000276:immunology; D006567:Herpesvirus 2, Saimiriine / Q000276:immunology; D007116:Immunization, Passive / Q000379:methods*; D007668:Kidney; D008253:Macaca mulatta; D014165:Transfer Factor / Q000008:administration & dosage* / Q000096:biosynthesis; D014412:Tumor Virus Infections / Q000276:immunology
D000956:Antigens, Viral; D014165:Transfer Factor