Chromosome abnormalities in bovine papillomavirus type 1-transformed Syrian hamster cells before and after tumor formation.
Syrian hamster embryonic fibroblasts transformed by infection with bovine papillomavirus type 1 cause tumors when inoculated into hamsters. Chromosome examinations revealed several abnormal clones in the transformed fibroblasts and a variety of additional markers in three tumors. Only one aberration, trisomy 11, was present in each cell. The extra chromosome #11, thus, is considered to be essential for tumor formation in this model system.
D000818:Animals; D052688:Bovine papillomavirus 1; D002472:Cell Transformation, Viral; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D006224:Cricetinae; D007621:Karyotyping; D009374:Neoplasms, Experimental / Q000235:genetics*; D014314:Trisomy