[Changes of the expression of histocompatibility (HLA) antigens in human fibroblasts transformed by the avian leukosis-sarcoma virus].
Monoclonal monomorphic antibodies anti-HLA class I and II antigens, were used to evaluate the expression of these molecules on normal and RSV-transformed human fibroblasts. The results indicate that the human diploid fibroblasts transformed in vitro by RSV present a reduced HLA-class I antigens expression as compared to the uninfected fibroblasts of the same donor. In parallel, it is demonstrated that the class II molecules absent on normal cells are expressed after transformation.
D001358:Avian Sarcoma Viruses; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D004797:Enzyme-Linked Immunosorbent Assay; D005347:Fibroblasts / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans
D006680:HLA Antigens
Modification de l'expression des antigènes d'histocompatibilité (HLA) dans des fibroblastes humains transformés par le virus de la leucosarcomatose aviaire (ASV).