Hepatitis B antigens and antibodies in serum from 41 cases of primary carcinoma of the liver. A study from Thailand.
Thirty-seven patients with hepatocellular carcinoma (HCC), one with cholangiocellular carcinoma (CCC), two with mixed HCC and CCC, and one with an anaplastic primary carcinoma of the liver, all from Bangkok, Thailand, were examined for the presence of hepatitis B virus infection markers in their blood. Of the patients with HCC, 70.6% had macronodular cirrhosis. Their serum was positive for hepatitis B surface antigen (HBsAg) in 64.9%, for hepatitis B core antibody (anti-HBc) in 97.3%, and for hepatitis B e antibody (anti-HBe) in 56.8% of the cases. The serum was positive for hepatitis B surface antibody (anti-HBs) in 53.9% of the HBsAg-negative and positive for hepatitis B e antigen (HBeAg) in 16.7% of the HBsAg-positive patients. The results of the study support the hypothesis of an etiological association between hepatitis B virus infection and HCC in Thailand.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000276:immunology*; D002648:Child; D005260:Female; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006511:Hepatitis B Antigens / Q000032:analysis*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013785:Thailand
D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens