Pancreatic B-cell peptides as parameters for diagnosis and localisation of hormone secreting tumours.
Insulin, C-peptide and proinsulin were measured in peripheral blood of 11 patients suffering from different types of hormone-producing pancreatic B-cell tumours. While proinsulin was elevated in 10/11 patients during prolonged fasting, C-peptide and insulin levels were found within the reference range in 5/11 and 3/5 cases respectively. A rapid insulin assay performed during surgery was helpful for localisation and identification of the respective tumours.
D007516:Adenoma, Islet Cell / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D002096:C-Peptide / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood*; D007340:Insulinoma / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D011384:Proinsulin / Q000097:blood*
D002096:C-Peptide; D007328:Insulin; D011384:Proinsulin