title: Pulmonary adenocarcinoma of fetal type: alternating differentiation argues in favour of a common endodermal stem cell.
abstract: Pulmonary adenocarcinoma exhibit different cell types that ultrastructurally, appear to be related to the different epithelial cell types occurring in the terminal lung lobule. The present paper describes the light-microscopical, ultrastructural and immunohistochemical features of a newly defined type of pulmonary adenocarcinoma that resembles an early stage of lung differentiation. The alternating epithelial differentiation within this tumour speaks in favour of a common endodermal stem cell for the different types of epithelial cells within the lung, including endocrine cells. The relationship of this tumour to pulmonary blastoma is discussed.
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000911:Antibodies, Monoclonal; D002454:Cell Differentiation; D004707:Endoderm / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology*; D013234:Stem Cells / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal