The effect of moderate urine alkalinisation on low dose diethylcarbamazine therapy in patients with onchocerciasis.
Twenty-one patients with moderate to heavy infections with O. volvulus were treated with 25 mg of diethylcarbamazine (DEC) citrate twice daily for 10 days. In 11 patients the urine was made alkaline with sodium bicarbonate, 2 g, administered 6 hourly for three doses daily beginning 1 day before DEC was started and continued throughout the DEC therapy. Ten patients served as controls. The mean pre-dose plasma DEC concentration during treatment and the mean plasma DEC half-life were significantly higher in bicarbonate treated patients as compared to controls. Total urinary excretion of DEC was significantly less in the bicarbonate treated group than in controls. Mean overall total reaction was higher in bicarbonate-treated patients but the difference was not significant. The bicarbonate-treated group achieved a significantly greater reduction in skin microfilarial counts than the control group as assessed 1 week after completion of therapy, but there was little difference at 1 month. Microfilarial killing was associated with microfilarial mobilisation, alteration in peripheral leucocytes and elevation in serum aminotransferases in both groups. There was no effect of DEC on the number of adult worms recovered in nodules removed at the end of the therapy. This study indicates that moderate urinary alkalinisation alters the kinetics of DEC and the therapeutic response. However the severity of clinical reaction coupled with the inadequate level of microfilarial killing achieved make it unlikely that manipulation of urinary pH will be of practical value in onchocerciasis chemotherapy.
D000293:Adolescent; D000328:Adult; D001639:Bicarbonates / Q000008:administration & dosage*; D004049:Diethylcarbamazine / Q000008:administration & dosage* / Q000097:blood; D004359:Drug Therapy, Combination; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008842:Microfilariae / Q000187:drug effects; D008875:Middle Aged; D009854:Onchocerca / Q000187:drug effects; D009855:Onchocerciasis / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D011897:Random Allocation; D012964:Sodium / Q000008:administration & dosage*; D017693:Sodium Bicarbonate; D000637:Transaminases / Q000097:blood
D001639:Bicarbonates; D017693:Sodium Bicarbonate; D012964:Sodium; D000637:Transaminases; D004049:Diethylcarbamazine