Inhibition of herpes simplex virus type 1 replication by halothane.
Halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) inhibited herpes simplex virus type 1 (HSV-1) replication, although HSV-1 DNA was synthesized at normal levels in Vero cells. Viral capsids and extracellular virions were inhibited, and HSV-1 protein synthesis decreased by 50%, although no specific HSV-1 protein failed to be synthesized. Hyperbaric pressure failed to reverse the halothane-induced inhibition of HSV-1 replication.
D002213:Capsid / Q000096:biosynthesis; D004279:DNA, Viral / Q000096:biosynthesis; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects*
D004279:DNA, Viral; D014764:Viral Proteins; D006221:Halothane