Nedocromil sodium inhibits IgE-dependent activation of rat macrophages and platelets as measured by schistosome killing, chemiluminescence and enzyme release.
The IgE-dependent activation of peritoneal macrophages and blood platelets can be measured by anti-parasite cytotoxicity, chemiluminescence and, in macrophages, lysosomal enzyme activity. Using these parameters, the present study demonstrates an inhibition by nedocromil sodium of the IgE-mediated stimulation of these non-mast cell inflammatory populations in the rat. These observations suggest that nedocromil sodium may be of value in the treatment of diseases of the lung where inflammatory mediator release is implicated.
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000201:enzymology; D007073:Immunoglobulin E / Q000494:pharmacology*; D008163:Luminescent Measurements; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000201:enzymology; D017835:Nedocromil; D010587:Phagocytosis / Q000187:drug effects*; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D012547:Schistosoma
D011804:Quinolines; D017835:Nedocromil; D007073:Immunoglobulin E