[Mechanism of Na,K-ATPase inhibition with gossypol and megasin].
Kinetic patterns of megosin and gossypol effects on properties of highly purified Na+, K+-ATPase were studied. Inhibition of the enzymatic activity appears to occur due to interaction of these compounds with the enzyme probound to the intracellular side of the transport enzyme.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006072:Gossypol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007679:Kidney Medulla / Q000201:enzymology; D007700:Kinetics; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013552:Swine
C026676:gossypol beta-aminoethyl sodium sulfate; D000254:Sodium-Potassium-Exchanging ATPase; D006072:Gossypol
Izuchenie mekhanizma ingibirovaniia Na,K-ATFazy gossipolom i megosinom.