Effects of the potentiation of the GABAergic neurotransmission in the olfactory bulbs on mouse-killing behavior.
Intra olfactory bulb administration of three classes of GABA-mimetics (GABAa agonists, inhibitors of reuptake, inhibitors of GABA degradation) clearly inhibit mouse-killing behavior, without sedation. A linear correlation is observed between GABA levels increase in the olfactory bulbs and muricidal inhibition following local injection of valproic acid and gamma-vinyl GABA, two GABA-T inhibitors; the differences observed between these two compounds may be due to the differences in their mechanism of action on GABA-T activity and to the different pool of GABA on which they act. No diffusion to extra bulbar sites were observed after local administration of gamma-vinyl GABA. This evidence suggests an inhibitory role of GABA from olfactory bulbs in the modulation of mouse-killing behavior.
D000374:Aggression / Q000187:drug effects*; D000614:Aminocaproates / Q000494:pharmacology; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D004357:Drug Synergism; D007539:Isonicotinic Acids / Q000494:pharmacology; D007555:Isoxazoles / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009118:Muscimol / Q000494:pharmacology; D009557:Nipecotic Acids / Q000494:pharmacology; D009830:Olfactory Bulb / Q000187:drug effects*; D011392:Proline / Q000031:analogs & derivatives*; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000187:drug effects*; D014635:Valproic Acid / Q000494:pharmacology; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000614:Aminocaproates; D007539:Isonicotinic Acids; D007555:Isoxazoles; D009557:Nipecotic Acids; C030278:nipecotic acid; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D011392:Proline; C010983:homoproline; D020888:Vigabatrin; C015542:gaboxadol; C015300:isoguvacine