The suppression of hippocampal potentials by the benzodiazepine antagonist Ro 15-1788 may be mediated by purines.
The benzodiazepine antagonist Ro 15-1788 has been reported to suppress paired pulse inhibition in the hippocampal slice. It is now shown that the depression of orthodromic synaptic transmission by Ro 15-1788 can be prevented by the adenosine antagonist 8-phenyl-theophylline, or by adenosine deaminase. Since Ro 15-1788 has previously been shown to inhibit adenosine-uptake into rat brain tissue, it is suggested that this property, leading to an accumulation of extracellular adenosine, may underlie its effects on synaptic transmission.
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D001569:Benzodiazepines / Q000037:antagonists & inhibitors*; D005071:Evoked Potentials / Q000187:drug effects; D005442:Flumazenil / Q000494:pharmacology*; D058787:GABA-A Receptor Antagonists; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects*; D011687:Purines / Q000378:metabolism*; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism
D058787:GABA-A Receptor Antagonists; D011687:Purines; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D005442:Flumazenil; D000241:Adenosine