Herpes simplex virus-stimulated gamma-interferon production by newborn mononuclear cells.
Blood mononuclear cells from newborns and from adults, immune or nonimmune to herpes simplex virus, were cultured with IL 2 and herpes simplex virus and the amount of gamma-interferon in the supernatant measured after 3 days. The newborn and nonimmune adult cells made equivalent trace amounts of gamma-interferon in cultures containing either herpes simplex virus or IL 2 alone and there was a 5- to 10-fold increase in cultures containing both. Experiments in which the Leu 11+ cells were either depleted or enriched suggest that this subset of natural killer cells is both necessary and sufficient for gamma-interferon production in the absence of immune T cells.
D000328:Adult; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D009000:Monocytes / Q000276:immunology*; D018139:Simplexvirus / Q000276:immunology*
D007376:Interleukin-2; D007371:Interferon-gamma