[Myeloperoxidase deficiency as a cause of recurrent infections].
Myeloperoxidase (MPO) deficiency is a common hereditary leukocyte function defect. A two year old girl with MPO-deficiency suffered from recurrent skin infections. No MPO-activity was detectable in leukocytes of her peripheral blood smears, while NBT reduction and chemotactic activity was normal. The quantitative enzyme determination in leukocyte sonicates confirmed the total MPO-deficiency in the girl's leukocytes and a partial MPO-deficiency in the cells of her mother. The patient leukocytes demonstrated also an impaired chemiluminescence.
D002634:Chemotaxis, Leukocyte; D002675:Child, Preschool; D005260:Female; D006098:Granulocytes / Q000502:physiology; D006801:Humans; D007962:Leukocytes / Q000201:enzymology; D008163:Luminescent Measurements; D009195:Peroxidase / Q000172:deficiency*; D012008:Recurrence; D012874:Skin Diseases, Infectious / Q000097:blood / Q000209:etiology*
D009195:Peroxidase
Der Myeloperoxidase-Mangel als Ursache rezidivierender Infektionen.