Effect of (Asu1,7)E-CT, synthetic analogue of eel-calcitonin, on nociceptive transmission.
The effect of (Asu1,7)E-CT a deaminodicarba-analogue of the synthetic eel-calcitonin on the nociceptive transmission has been studied in mice. The analogue was intracerebroventricularly (0.0.5-0.01-0.02 U.I./kg) or intravenously (0.02-0.04-0.05 -0.1 U.I./kg) injected. This synthetic derivative of eel-calcitonin increased the antinociceptive effect also after peripheral administration. Moreover, preliminary studies on the time-course of this analogue showed that the dose of 0.1 U.I./kg i.v. injected, was able to elicit antinociceptive effect, already 5 min after the administration.
D000818:Animals; D016227:Benzoquinones; D002116:Calcitonin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009619:Nociceptors / Q000187:drug effects*; D011809:Quinones / Q000037:antagonists & inhibitors; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors
D016227:Benzoquinones; D011809:Quinones; C029322:phenylbenzoquinone; D002116:Calcitonin; C012755:elcatonin