Regulation of phytohemagglutinin-induced bovine lymphocyte blastogenesis by leukotrienes.
Leukotriene (LT) B4, a 5-lipoxygenase metabolite of arachidonic acid, is a potent inducer of suppressor cells in phytohemagglutinin-stimulated cultures of bovine peripheral blood mononuclear cells. In contrast, LTC4 and LTD4 have little activity. Incubation of T lymphocytes with LTB4 at concentrations as low as 1 X 10(-12)M rendered these lymphocytes suppressive of [3H]thymidine incorporation in subsequent phytohemagglutinin-stimulated cultures of fresh autologous lymphocytes. This LTB4-induced cell was radiosensitive to irradiation at 2,000 rads. Leukotriene B4 may have an important part in immunoregulation during hypersensitivity reactions.
D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D007975:Leukotriene B4 / Q000502:physiology*; D008214:Lymphocytes / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000494:pharmacology*; D013189:SRS-A / Q000502:physiology
D010835:Phytohemagglutinins; D013189:SRS-A; D007975:Leukotriene B4