The effects of acute respiratory virus infection upon tracheal mucous transport.
Tracheal mucous velocity was measured in 13 healthy non-smokers using a radioisotope-labeled aerosol and a multidetector probe during respiratory virus infections. The movement of boluses of tracheal mucous were either absent or reduced in number in five subjects with myxovirus infection (four influenza and one respiratory syncytial virus) within 48 hr of the onset of symptoms and in four subjects 1 wk later. One subject with influenza still had reduced bolus formation 12-16 wk after infection. Frequent coughing was a feature of those subjects with absent tracheal boluses. In contrast, four subjects with rhinovirus infection had normal tracheal mucous velocity at 48 hr after the onset of symptoms (4.1 +/- 1.3 mm/min). Tracheal mucous velocity was also normal (4.6 +/- 1.1 mm/min) in four subjects in whom no specific viral agent could be defined but of respiratory viral infection. During health tracheal mucous velocity was (4.8 +/- 1.6 mm/min) in the eleven subjects who had measurements made. Disturbances in tracheal mucous transport during virus infection appear to depend upon the type of virus and are most severe in influenza A and respiratory syncytial virus infection.
D000328:Adult; D000336:Aerosols; D000547:Amantadine / Q000627:therapeutic use; D006801:Humans; D009093:Mucus / Q000378:metabolism*; D009975:Orthomyxoviridae / Q000302:isolation & purification*; D010850:Picornaviridae Infections / Q000188:drug therapy / Q000503:physiopathology*; D012229:Rhinovirus / Q000302:isolation & purification; D013667:Technetium; D014133:Tracheal Diseases / Q000188:drug therapy / Q000503:physiopathology*
D000336:Aerosols; D013667:Technetium; D000547:Amantadine