Contribution of arachidonic acid metabolites to atherosclerosis.
Evidence is presented that arachidonic acid metabolites are involved to an important extent in platelet-arterial wall interaction. The perspectives opened up by these results are the possible prevention and therapy of atherosclerosis by a fish-diet containing eicosapentaenoic acid, the use of prostaglandins, releasers of endogenous PGI2 and thromboxane synthetase inhibitors.
D001095:Arachidonic Acids / Q000097:blood*; D001161:Arteriosclerosis / Q000201:enzymology* / Q000517:prevention & control; D001792:Blood Platelets / Q000201:enzymology; D000242:Cyclic AMP / Q000097:blood; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage; D011464:Epoprostenol / Q000097:blood; D005227:Fatty Acids / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008055:Lipids / Q000097:blood; D009131:Muscle, Smooth, Vascular / Q000201:enzymology; D010974:Platelet Aggregation; D011449:Prostaglandin Endoperoxides / Q000097:blood; D011451:Prostaglandin-Endoperoxide Synthases / Q000097:blood; D013928:Thromboxane A2 / Q000097:blood
D001095:Arachidonic Acids; D005227:Fatty Acids; D008054:Lipid Peroxides; D008055:Lipids; D011449:Prostaglandin Endoperoxides; D013928:Thromboxane A2; D015118:Eicosapentaenoic Acid; D011464:Epoprostenol; D000242:Cyclic AMP; D011451:Prostaglandin-Endoperoxide Synthases