Effects of inhibitors of arachidonic acid metabolism on intercellular adhesion of SV40-3T3 cells.
Mepacrine, an inhibitor of arachidonic acid mobilisation, and NDGA, a lipoxygenase inhibitor, were found to impair the aggregation of SV40-3T3 cells but the effects could not be unequivocally dissociated from non-specific actions of the drugs. No effect on aggregation was observed even after prolonged exposure of the cells to the cyclooxygenase inhibitors aspirin and indomethacin. These results argue against a possible regulatory role for endogenous AA metabolites in intercellular adhesion of SV40-3T3 cells.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors / Q000378:metabolism*; D001241:Aspirin / Q000494:pharmacology*; D002396:Catechols / Q000494:pharmacology*; D002449:Cell Aggregation / Q000187:drug effects*; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D016861:Cyclooxygenase Inhibitors; D007213:Indomethacin / Q000494:pharmacology*; D009637:Masoprocol / Q000494:pharmacology*; D051379:Mice; D011796:Quinacrine / Q000494:pharmacology*; D013539:Simian virus 40 / Q000235:genetics
D001095:Arachidonic Acids; D002396:Catechols; D016861:Cyclooxygenase Inhibitors; D016718:Arachidonic Acid; D009637:Masoprocol; D011796:Quinacrine; D001241:Aspirin; D007213:Indomethacin