title: Effects of atriopeptins on relaxation and cyclic GMP levels in human coronary artery in vitro.
abstract: The effects of atriopeptins on relaxation and cyclic GMP levels were examined in human coronary artery. alpha-Atrial natriuretic polypeptide and atriopeptins I, II and III all induced relaxation. Relaxations to atriopeptin I were of a smaller magnitude. The atriopeptins elevated cyclic GMP levels from 2- to 3-fold. These studies suggest that atriopeptins released from the heart may dilate the vasculature of this organ and increase coronary blood flow through the formation of cyclic GMP.
mesh_terms: D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D003331:Coronary Vessels / Q000187:drug effects / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D011189:Potassium Chloride / Q000494:pharmacology
chemical_list: D011189:Potassium Chloride; D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP