title: Anti-oxidant effects of retinoids on inflammatory skin diseases.
abstract: It is well known that retinoids are effective in the treatment of various dermatological disorders. It has been reported that retinoids have inhibitory effects on the generation of superoxide (O2-) by stimulated polymorphonuclear leukocytes (PMNs). In the present study, we investigated the effects of retinoids on the generation of O2- and other reactive oxygen species (ROS), including OH., H2O2 and chemiluminescence, by zymosan-stimulated PMNs and in the xanthine-xanthine oxidase system, because these potent ROS may play an important role in PMN-mediated skin inflammation. It was found that some retinoids had antioxidant effects in the PMN system; however, apart from the effect of tretinoin and Ro 10-1670 on OH. generation, none of the retinoids studied inhibited ROS generation in the xanthine-xanthine oxidase system. On the basis of these results, we discuss a possible mechanism connected with the role of ROS by which retinoids have favourable effects on several inflammatory skin disorders.
mesh_terms: D000975:Antioxidants; D003872:Dermatitis / Q000188:drug therapy* / Q000378:metabolism; D005050:Etretinate / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D012176:Retinoids / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism; D019820:Xanthine; D014969:Xanthine Oxidase / Q000378:metabolism; D014970:Xanthines / Q000378:metabolism; D015054:Zymosan
chemical_list: D000975:Antioxidants; D006878:Hydroxides; D012176:Retinoids; D014970:Xanthines; D013481:Superoxides; D019820:Xanthine; D017665:Hydroxyl Radical; D005050:Etretinate; D015054:Zymosan; D006861:Hydrogen Peroxide; D014969:Xanthine Oxidase