Relationships between medial hypothalamic alpha 2-receptor binding, norepinephrine, and circulating glucose.
These experiments examine the dependence of medial hypothalamic alpha 2-receptor binding on the availability of circulating glucose. Food deprivation and tolbutamide-induced hypoglycemia both diminished alpha 2-binding. These binding results were highly correlated with serum glucose levels. Prevention of tolbutamide hypoglycemia by concomitant injections of dextrose blocked the effects on alpha 2-binding. Injection of norepinephrine into the medial hypothalamic sites that normally elicit feeding behavior elevated serum glucose. These results suggest a homeostasis for control of glucose in a hypothalamic feeding system.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003000:Clonidine / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D005508:Food Deprivation / Q000502:physiology; D007033:Hypothalamus, Middle / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D014044:Tolbutamide / Q000494:pharmacology
D001786:Blood Glucose; D011942:Receptors, Adrenergic, alpha; C016986:apraclonidine; D014044:Tolbutamide; D003000:Clonidine; D009638:Norepinephrine