Vasoactive intestinal polypeptide increases inositol phospholipid breakdown in the rat superior cervical ganglion.
The effects of VIP and of peptides of the VIP family: secretin, glucagon, the porcine histidine isoleucine containing peptide (PHI) and the rat hypothalamic growth hormone-releasing hormone (rhGRF) on the cyclic AMP and inositol phosphate contents of isolated rat superior cervical ganglia were investigated. We demonstrate that VIP is able to provoke a large inositol lipid breakdown by acting directly on ganglionic cells. This observation suggests the presence in rat superior cervical ganglia of a new type of receptors for VIP or for an unidentified peptide structurally related to VIP.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D000242:Cyclic AMP / Q000032:analysis*; D005728:Ganglia, Sympathetic / Q000032:analysis*; D007295:Inositol Phosphates / Q000032:analysis*; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013403:Sugar Phosphates / Q000032:analysis*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D007295:Inositol Phosphates; D010455:Peptides; D013403:Sugar Phosphates; D001127:Arginine Vasopressin; D014660:Vasoactive Intestinal Peptide; D002217:Carbachol; D000242:Cyclic AMP