title: A prototype epithermal neutron beam for boron neutron capture therapy.
abstract: An epithermal neutron beam has been designed and tested at the Georgia Institute of Technology's 5-MW Research Reactor. The prototype facility consists of aluminum and sulfur disks in a tangential beam port for fast neutron filtration. A cadmium sheet at the port exit removes the thermal neutrons from the transmitted beam, leaving an intensely epithermal neutron beam spanning five energy decades, each contributing to the flux demanded by boron neutron capture therapy. The thermal neutron flux generated by the incident epithermal neutrons in a polyethylene head phantom peaks at a depth of 3 cm and remains above the incident thermal flux to a 7-cm depth. The beam thus provides the penetration required for treating deep-seated gliomas. Photon contamination in the prototype facility is high, and a number of basic modifications are proposed for reducing it to safer levels.
mesh_terms: D001895:Boron / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D005214:Fast Neutrons / Q000627:therapeutic use; D005374:Filtration / Q000295:instrumentation; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D007554:Isotopes / Q000627:therapeutic use*; D008953:Models, Anatomic; D011879:Radiotherapy Dosage
chemical_list: D007554:Isotopes; D001895:Boron