title: [3H-diazepam binding to brain synaptic membranes during the development of generalized epileptic activity].
abstract: The development of bemegride-induced generalized epileptic activity in rats was shown to reduce the constant (CB). of specific 3H-diazepam binding with synaptic membranes from 0.23 nM-1 to 0.15 nM-1 and to increase the maximum number of membrane binding sites (Bmax) from 410 fmol/mg protein to 550 fmol/mg protein. It is assumed that the changes of benzodiazepine receptor properties are due to alteration in physico-chemical characteristics of synaptic membrane lipids resulting from the activation of lipid peroxidation.
mesh_terms: D000818:Animals; D001534:Bemegride / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003975:Diazepam / Q000378:metabolism*; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000378:metabolism; D013570:Synaptic Membranes / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors; D014316:Tritium
chemical_list: D017981:Receptors, Neurotransmitter; D014316:Tritium; D001534:Bemegride; D003975:Diazepam
vernacular_title: Sviazyvanie 3H-diazepama s sinapticheskimi membranami mozga pri razvitii generalizovannoĭ épilepticheskoĭ aktivnosti.