Is Metaphit a phencyclidine antagonist? Studies with ketamine, phencyclidine and N-methylaspartate.
The dissociative anaesthetics, phencyclidine and ketamine, block excitation of central neurones by N-methylaspartate. Using the technique of microelectrophoresis on rat spinal neurones in vivo Metaphit, a phencyclidine receptor acylating agent, was tested to see whether it would antagonise this effect of dissociative anaesthetics. The predominant effect of Metaphit was, however, to reduce N-methylaspartate induced excitation. It is concluded that Metaphit has mixed agonist/antagonist effects at the phencyclidine receptor.
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D003864:Depression, Chemical; D004347:Drug Interactions; D007608:Kainic Acid / Q000494:pharmacology; D007649:Ketamine / Q000494:pharmacology*; D016202:N-Methylaspartate; D009474:Neurons / Q000187:drug effects; D010069:Oxadiazoles / Q000494:pharmacology; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D016318:Quisqualic Acid; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects; D017480:Receptors, sigma; D013116:Spinal Cord / Q000187:drug effects*
D010069:Oxadiazoles; D011957:Receptors, Opioid; D017480:Receptors, sigma; D001224:Aspartic Acid; D016202:N-Methylaspartate; D007649:Ketamine; D016318:Quisqualic Acid; C044705:metaphit; D010622:Phencyclidine; D007608:Kainic Acid