A study of the HLA-D region in patients with classic Kaposi's sarcoma.
The HLA-D region in nine Sardinian patients with classic Kaposi's sarcoma was studied with two restriction enzymes, Eco RI and Eco RV, and two cDNA probes, DR beta and DQ beta. A total of 41 polymorphic restriction fragments were identified. One, an 11.5 kb Eco RV DQ beta fragment, was present in three of the patients but in none of the controls; a second, an 8.0 kb Eco RV DR beta fragment, was present in six patients and all the controls. No single fragment was identified which was significantly over or under-represented in either group.
D000483:Alleles; D004262:DNA Restriction Enzymes; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D007558:Italy; D011110:Polymorphism, Genetic; D012514:Sarcoma, Kaposi / Q000235:genetics* / Q000276:immunology
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D004262:DNA Restriction Enzymes