[Use of metronidazole in the preoperative irradiation of stomach cancer patients].
Altogether 70 patients received combined therapy for stomach cancer. A course of gamma-beam therapy (a summary focal dose of 20 Gy) combined with metronidazole was given at the first stage. Three-five days after the discontinuation of radiation therapy the patients were operated upon. Forty-nine (70%) patients were subjected to radical operation. The area of surgical intervention ranged from subtotal resection of the stomach to combined gastrectomy. Lethality after radical operations was 7.5%. Pronounced and extensive dystrophic changes were found in tumors at microscopic examination of resected specimens.
D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D002288:Adenocarcinoma, Mucinous / Q000473:pathology / Q000628:therapy*; D000231:Adenocarcinoma, Papillary / Q000473:pathology / Q000628:therapy*; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D009367:Neoplasm Staging; D011300:Preoperative Care / Q000379:methods*; D011879:Radiotherapy Dosage; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology / Q000628:therapy*; D013997:Time Factors
D008795:Metronidazole
Primenenie metronidazola pri predoperatsionnom obluchenii bol'nykh rakom zheludka.