Schizophrenia as a disorder of cerebral state transition.
This paper offers a speculative consideration of the schizophrenic process in the light of recent findings concerning the wave nature of electrocortical activity. These findings indicate that changes of brain state can be described in the terminology of finite-state machines, and both the instantaneous states and the state transitions can be specified. It is suggested that the mental phenomena of schizophrenia may be reducible to events (some specific type of instability) which could be observed by appropriate analytic techniques applied to EEG. Present empirical EEG findings in schizophrenics are reviewed in this light, and the role of dopamine blockade in treatment is also considered.
D001143:Arousal / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology; D003712:Dendrites / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D004569:Electroencephalography; D005071:Evoked Potentials; D006801:Humans; D009434:Neural Pathways / Q000503:physiopathology; D011954:Receptors, Dopamine / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*; D009435:Synaptic Transmission
D011954:Receptors, Dopamine; D004298:Dopamine