Mu and kappa opiate receptor involvement in agonistic behaviour in mice.
The influence of opioid drugs on agonistic behaviour is reviewed and an experiment is reported that examines the impact of U-50488 (a kappa agonist) and DAGO (a mu agonist) on the social encounters of male and female mice interacting with anosmic male partners. Although DAGO did not significantly influence inter-male social encounters, U-50488 decreased social investigation, increased timid/defensive behaviour and potently suppressed aggression. In contrast, U-50488 did not significantly influence the behaviour of timid female mice, whereas DAGO decreased social and timid/defensive behaviour. It was concluded that a kappa mechanism increases whereas a mu mechanism decreases submissive behaviour.
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000374:Aggression / Q000187:drug effects*; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004745:Enkephalins / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D011759:Pyrrolidines / Q000494:pharmacology; D011957:Receptors, Opioid / Q000502:physiology*; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D012919:Social Behavior / Q000187:drug effects; D013997:Time Factors
D000700:Analgesics; D004745:Enkephalins; D011759:Pyrrolidines; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer