The role of presynaptic beta-receptors in Raynaud's disease.
This report concerns the results of a study carried out to show the presence of presynaptic Beta adrenergic receptor supersensitivity in RD patients and the possibility to prevent or at least decrease this supersensitivity with Beta-blocker treatment. It is shown that the paradoxical vasoconstriction response to ISP infusion can be prevented in RD patients by the acute administration of Beta-blocker, such as Atenolol or DL Propranolol. Moreover, chronic treatment with the correct Beta-blocker was seen to prevent angiospastic crisis in these patients.
D000328:Adult; D001262:Atenolol / Q000627:therapeutic use; D005246:Feedback; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use; D011928:Raynaud Disease / Q000188:drug therapy / Q000503:physiopathology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D013570:Synaptic Membranes / Q000502:physiology
D011943:Receptors, Adrenergic, beta; D001262:Atenolol; D011433:Propranolol; D007545:Isoproterenol