title: The effects of acute intraseptal injection of haloperidol in vivo on hippocampal cholinergic function in the mouse.
abstract: Acute injection of haloperidol into the lateral septum in mice produced an immediate and long-lasting increase in hippocampal sodium-dependent high-affinity choline uptake. Parallel electrophysiological investigations revealed that the increased septo-hippocampal cholinergic activity augmented CA1 pyramidal cell excitability and also accelerated the extinction of a conditioned reinforcement. These results constitute further evidence that septal dopaminergic terminals, via their control of septo-hippocampal cholinergic activity play a significant role in the modulation of hippocampal function.
mesh_terms: D000818:Animals; D002794:Choline / Q000378:metabolism; D002799:Cholinergic Fibers / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology*; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009434:Neural Pathways / Q000502:physiology; D012688:Septum Pellucidum / Q000187:drug effects* / Q000502:physiology; D012964:Sodium / Q000502:physiology; D009435:Synaptic Transmission
chemical_list: D012964:Sodium; D006220:Haloperidol; D002794:Choline; D004298:Dopamine