Cytotoxic T-lymphocyte recognition of simian virus 40 antigens.
During the transformation of mammalian cells by SV40, the cells acquire new antigenicity at the cell surface that acts as a target for cytotoxic T lymphocytes. Evidence is discussed which leads to the conclusion that the product of the SV40 tsA gene, the T antigen, is directly involved in converting a cell to malignant phenotype, is largely localized in the nucleus of transformed cells and is also present at the cell surface. Therefore, it appears that the T antigen serves a dual function, i.e. it is involved in the initiation and maintenance of transformation and provides a target for the immune effector mechanisms in the host undergoing viral carcinogenesis.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D002471:Cell Transformation, Neoplastic; D006649:Histocompatibility Antigens / Q000276:immunology; D006801:Humans; D013539:Simian virus 40 / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D006649:Histocompatibility Antigens; C029237:tumor-associated transplantation antigen