Organ distribution of asialo-red blood cell ghosts: an attempt at targeting to the liver.
We investigated the organ distribution of four types of red blood cells (RBC) preparations: native RBC, asialo-RBC, native ghosts and asialo-ghosts. Intravenously injected asialo-ghosts were rapidly removed from the blood stream and accumulated mainly in the liver 120 min after the injection. Our results suggest that asialo-ghosts are a simple and effective carrier for targeting of drugs to the liver.
D000818:Animals; D001212:Asialoglycoproteins / Q000502:physiology; D002860:Chromium Radioisotopes; D004910:Erythrocyte Membrane / Q000378:metabolism / Q000502:physiology*; D004912:Erythrocytes / Q000187:drug effects*; D007275:Injections, Intravenous; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis* / Q000648:ultrastructure; D051379:Mice; D008815:Mice, Inbred Strains; D009439:Neuraminidase / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000378:metabolism; D013154:Spleen / Q000032:analysis; D013997:Time Factors; D014018:Tissue Distribution
D001212:Asialoglycoproteins; D002860:Chromium Radioisotopes; D011956:Receptors, Cell Surface; C039707:galactose receptor; D009439:Neuraminidase