[Correlation between nasopharyngeal carcinoma (NPC) and HLA in Hunan Province].
24 patients with NPC and 49 normal individuals in Hunan Province were typed for their HLA-A and -B antigens. The results showed that the antigen frequencies of HLA-A1 and HLA-Bw63 were significantly higher in NPC patient group than in the normal group (P = 0.0098 and P = 0.0028, respectively) and the antigen frequency of HLA-A11 was significantly lower in NPC patient group than in the normal group (P = 0.0075). In addition, the joint occurrence of A2 and B17 was increased in NPC patient group (P = 0.0350). The results suggested that HLA-A1 be a regional antigen associated with NPC in Hunan or Southern China, and that HLA-Bw63 be a new kind of antigen associated with NPC.
D002681:China; D006680:HLA Antigens / Q000032:analysis*; D015788:HLA-A1 Antigen; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000276:immunology*
D006680:HLA Antigens; D015788:HLA-A1 Antigen; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; C037449:HLA-B17 antigen; C050053:HLA-B63 antigen