title: [Indices of lymphocyte functional activity in patients with recurrent cutaneous-genital herpes during treatment with a herpes vaccine].
abstract: The functional activity of lymphocytes of patients with severe forms of recurrent cutaneous-genital herpes was studied in the course of treatment with inactivated polyvalent herpes vaccine on the basis of lymphocyte blast-transformation response to polyclonal mitogens and herpes simplex virus antigen. In the group of patients who showed a marked therapeutic effect as a result of the treatment the initially high values of the antigen-dependent lymphocyte blast-transformation test declined and became normal. Thus, in some cases the herpes vaccine exerts an immunomodulating effect normalizing the functions of different lymphocyte subpopulations.
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D003131:Combined Modality Therapy; D005260:Female; D006072:Gossypol / Q000031:analogs & derivatives / Q000627:therapeutic use; D006558:Herpes Genitalis / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007369:Interferon Inducers / Q000627:therapeutic use; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology; D011131:Polyribonucleotides; D012008:Recurrence; D018139:Simplexvirus / Q000276:immunology*; D012874:Skin Diseases, Infectious / Q000276:immunology* / Q000628:therapy; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D014765:Viral Vaccines / Q000627:therapeutic use*
chemical_list: D007369:Interferon Inducers; D008934:Mitogens; D011131:Polyribonucleotides; D014765:Viral Vaccines; C044366:poludan; C026676:gossypol beta-aminoethyl sodium sulfate; D006072:Gossypol
vernacular_title: Pokazateli funktsional'noĭ aktivnosti limfotsitov bol'nykh retsidiviruiushchim kozhno-genital'nym gerpesom v protsesse lecheniia gerpeticheskoĭ vaktsinoĭ.