Mathematical description of the interaction between prostaglandins and calcium.
The interpretation of the biological action of prostaglandins is very difficult because the shape of the dose-response curves in different assays is often unusual. Horrobin has attempted to explain these unusual curves by supposing special interactions between Ca and the prostaglandin receptors. This paper gives a mathematical description of his theoretical models. The results of computer simulation based on these models were in good agreement with the reported experimental observations.
D001667:Binding, Competitive; D001711:Biotransformation; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D003201:Computers; D008433:Mathematics; D008956:Models, Chemical; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011982:Receptors, Prostaglandin / Q000378:metabolism*
D002135:Calcium-Binding Proteins; D011956:Receptors, Cell Surface; D011982:Receptors, Prostaglandin