Dibutyryl cyclic guanine monophosphate inhibits natural but not limb amputation-induced motoneurone death in the chick embryo.
The number and distribution of motoneurones in the lateral motor columns of normal chick embryos have been compared with embryos treated daily with dibutyryl cyclic guanine monophosphate and subject to unilateral limb bud amputation. Treatment with cyclic nucleotide rescued about 17% of the motoneurones compared with controls by Stage 37, but did not prevent amputation-induced motoneurone death. The role of cyclic nucleotides in motoneurone survival is therefore permissive, rather than instructive.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002642:Chick Embryo; D006152:Cyclic GMP / Q000031:analogs & derivatives*; D003995:Dibutyryl Cyclic GMP / Q000494:pharmacology*; D005121:Extremities / Q000196:embryology; D009046:Motor Neurons / Q000187:drug effects*; D009132:Muscles / Q000196:embryology; D013116:Spinal Cord / Q000187:drug effects* / Q000196:embryology
D003995:Dibutyryl Cyclic GMP; D006152:Cyclic GMP