Investigation of the parameters related to the formation of 99mTc-pyrophosphate complexes using gel chromatography column scanning.
Using gel chromatography two different 99mTc-PPi complexes (complex I and II) were observed under various pH-values. In neutral medium complex II was the main product while in acidic or alkaline media complexes I and II were formed. Our results related to the organ distribution in mice revealed that complex II is a bone-seeking agent whereas complex I concentrates in the kidneys.
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002850:Chromatography, Gel; D011756:Diphosphates / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000000981:diagnostic imaging; D051379:Mice; D011817:Rabbits; D011877:Radionuclide Imaging; D013667:Technetium / Q000378:metabolism; D016698:Technetium Tc 99m Pyrophosphate; D014018:Tissue Distribution
D011756:Diphosphates; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium