Free-radical-mediated DNA binding.
Free-radical metabolites can be generated metabolically by a one-electron reductase-catalyzed reaction or a "peroxidase" catalyzed oxidation or by photoactivation of a wide variety of aromatic xenobiotics. Radicals may also be generated during lipid peroxidation. Some radicals can react with DNA or bind covalently or noncovalently as a dismutation product or as a dimer, trimer or polymeric product. Modification to the DNA can result in single-strand breaks, loss of template activity, and crosslinking. The binding can prevent enzymic digestion. In some cases, the radicals react with oxygen, resulting before conversion to DNA reactive oxygen species. Most radicals probably do not interact with DNA.
D000818:Animals; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism / Q000633:toxicity; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D008054:Lipid Peroxides / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D010084:Oxidation-Reduction; D010636:Phenols / Q000378:metabolism / Q000633:toxicity; D010777:Photochemistry; D011083:Polycyclic Compounds / Q000378:metabolism
D005231:Fatty Acids, Unsaturated; D005609:Free Radicals; D006878:Hydroxides; D008054:Lipid Peroxides; D010636:Phenols; D011083:Polycyclic Compounds; D017665:Hydroxyl Radical; D004247:DNA; D006861:Hydrogen Peroxide