Steroid regulation of Na+/K+-ATPase activity in the rat kidney: effect of a new 19-nor-progestagen.
The effects of Nomegestrol acetate (17 alpha-acetoxy-6-methyl-19-nor-4,6-pregnadiene-3,20-dione), a new 19-nor-progesterone derivative, on renal Na+/K+-ATPase activity were assessed in normal and adrenalectomized rats, and compared with the stimulatory or inhibitory actions produced by other steroids. This compound displayed an inhibitory effect which was similar to, but smaller than, that induced by progesterone and quite distinct from the stimulation produced by 19-nor-progesterone and corticosteroids. In addition, unlike progesterone, it did not antagonize the effect of aldosterone in adrenalectomized rats. This result, together with previous in-vivo and in-vitro observations on this compound indicates that additional modifications introduced in the molecular structure of 19-nor-progesterone produces a potent progestagenic substance virtually devoid of effects on renal Na+/K+-ATPase activity and sodium loss in urine.
D000315:Adrenalectomy; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003864:Depression, Chemical; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008535:Megestrol; D051379:Mice; D008815:Mice, Inbred Strains; D009649:Norpregnadienes / Q000494:pharmacology*; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D009649:Norpregnadienes; C038501:nomegestrol acetate; D008535:Megestrol; D000254:Sodium-Potassium-Exchanging ATPase