The effects of beta-carboline carboxylic acid ethyl ester and its free acid, administered ICV, on the anticonvulsant activity of diazepam and sodium valproate in the mouse.
The effects of intracerebroventricular (ICV) beta-carboline carboxylic acid ethyl ester (beta-CCE) and its free acid on the protective effects of diazepam against leptazol- and R05-3663-induced convulsions were investigated in mice and compared with their effects on the antileptazol effect of sodium valproate, in an attempt to demonstrate a specific central effect of beta-CCE on benzodiazepine function. The results show that a small dose (1 microgram) of beta-CCE but not its free acid (in doses of up to 100 micrograms) was able to reverse the protective effects of diazepam against leptazol- and R05-3663-induced convulsions, whereas the effects of sodium valproate, a nonbenzodiazepine anticonvulsant, could not be reversed by these beta-carboline derivatives.
D000818:Animals; D001570:Benzodiazepinones / Q000008:administration & dosage; D002243:Carbolines / Q000494:pharmacology*; D003975:Diazepam / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D004347:Drug Interactions; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D010433:Pentylenetetrazole / Q000008:administration & dosage; D011963:Receptors, GABA-A / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced*; D014635:Valproic Acid / Q000008:administration & dosage*
D001570:Benzodiazepinones; D002243:Carbolines; D011963:Receptors, GABA-A; D014635:Valproic Acid; C022193:Ro 5-3663; C024915:beta-carboline-3-carboxylic acid ethyl ester; C049236:carboline-3-carboxylic acid; D003975:Diazepam; D010433:Pentylenetetrazole