[Spin label study of structural changes at different depths of phospholipid membranes after their peroxidation].
Changes of structural organization of liposomal phospholipid membranes, after their Fe2+-induced peroxidation were studied at different depth using nitroxyl derivatives of stearic acid. It was established that during Fe2+-induced lipid peroxidation a strong rise in lipid polarity accompanied with immobilization of acyl chains of phospholipids at the depth of 0.6-0.8 nm from the surface was measured. At the same time no significant changes in the structural organization were seen at the depth of 20-22 nm.
D004578:Electron Spin Resonance Spectroscopy; D005296:Ferrous Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D008054:Lipid Peroxides / Q000032:analysis*; D008081:Liposomes / Q000032:analysis*; D008563:Membrane Lipids / Q000032:analysis*; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000032:analysis*; D013050:Spectrometry, Fluorescence; D013113:Spin Labels
D005296:Ferrous Compounds; D008054:Lipid Peroxides; D008081:Liposomes; D008563:Membrane Lipids; D010743:Phospholipids; D013113:Spin Labels
Izuchenie metodom spinovykh zondov strukturnykh izmeneniĭ na razlichnoĭ glubine fosfolipidnykh membran posle ikh peroksidatsii.