title: Chronic Epstein-Barr virus infection associated with fever and interstitial pneumonitis. Clinical and serologic features and response to antiviral chemotherapy.
abstract: Two patients developed fever, interstitial pneumonitis, and pancytopenia associated with extremely high titers of antibody to replicative antigens of the Epstein-Barr virus. In contrast to most patients seropositive for Epstein-Barr virus, neither patient had an antibody response to the Epstein-Barr nuclear antigen K polypeptide. In addition, virus isolated from one patient had a deletion of the B95-8 type in the EcoRI C region of the genome. An etiologic relation between Epstein-Barr virus replication and the clinical manifestations of this syndrome is further shown by the response of each patient to acyclovir therapy. These patients have a new Epstein-Barr-virus-associated syndrome and provide additional evidence that acyclovir may play a role in therapy for selected patients with Epstein-Barr virus infection.
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D002908:Chronic Disease; D005260:Female; D005334:Fever / Q000209:etiology*; D005814:Genes, Viral; D006566:Herpesviridae Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology / Q000502:physiology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008168:Lung / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000209:etiology*; D014779:Virus Replication
chemical_list: D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D000212:Acyclovir