Cerebral-evoked responses elicited by direct stimulation of the lateral spinothalamic tract in the human.
The authors recorded cerebral-evoked responses elicited by direct stimulation of the human lateral spinothalamic tract (LST) during percutaneous cordotomy to investigate central conduction of noxious stimuli. These responses consisted of four negative potentials, peak latency being 3.8 (N1), 8.4 (N2), 12.2 (N3) and 21.9 (N4) ms respectively. N1 showed wide distribution over the scalp and was considered to be of subcortical origin. N2-N4 were distributed in both the temporal and central area. The different distribution pattern of N2-N4 from conventional somatosensory-evoked potential suggested a different projection of LST from the medial lemniscus system.
D000328:Adult; D000368:Aged; D002540:Cerebral Cortex / Q000503:physiopathology*; D004292:Dominance, Cerebral / Q000502:physiology; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000503:physiopathology; D009619:Nociceptors / Q000503:physiopathology*; D010146:Pain / Q000503:physiopathology*; D013133:Spinothalamic Tracts / Q000503:physiopathology*; D009435:Synaptic Transmission