Ecto-5'-nucleotidase can use IMP to provide the total purine requirements of mitogen-stimulated human T cells and human B lymphoblasts.
D015720:5'-Nucleotidase; D000630:Aminopterin / Q000494:pharmacology; D001377:Azaserine / Q000494:pharmacology; D001402:B-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D001692:Biological Transport; D002453:Cell Cycle / Q000187:drug effects; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism; D066298:In Vitro Techniques; D007288:Inosine / Q000378:metabolism; D007291:Inosine Monophosphate / Q000378:metabolism*; D007292:Inosine Nucleotides / Q000378:metabolism*; D008213:Lymphocyte Activation; D009708:Nucleotidases / Q000378:metabolism*; D014176:Protein Biosynthesis; D011687:Purines / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism*
D007042:Hypoxanthines; D007292:Inosine Nucleotides; D011687:Purines; D007291:Inosine Monophosphate; D019271:Hypoxanthine; D007288:Inosine; D001377:Azaserine; D004247:DNA; D009708:Nucleotidases; D015720:5'-Nucleotidase; D000630:Aminopterin