The importance of sodium and chloride ions for the development of DOCA-NaCl hypertension: a haemodynamic study.
The role of sodium and its accompanying anion for the development of DOCA-salt hypertension was studied in uninephrectomized DOCA-treated weanling Wistar rats which were fed a diet containing either sodium chloride or sodium bicarbonate (170 mmol/kg). The blood pressure was increased in both groups of rats with sodium overload as compared to rats fed a low-salt diet only. A decreased cardiac output and substantially elevated systemic resistance were demonstrated in both groups of rats with high sodium intake in comparison with rats kept on a low-salt diet. However, these haemodynamic changes were more pronounced in rats with sodium chloride overload than in animals with a high sodium bicarbonate intake. On the other hand, the rigidity of major arteries which was estimated as the pulse pressure/stroke volume ratio, was increased only in rats fed a diet with sodium chloride but not in rats with sodium bicarbonate overload. Thus high sodium intake was responsible for the changes of systemic resistance in DOCA-treated animals and its action was only slightly augmented by a high chloride intake. In contrast to this, the chloride overload seemed to be essential for the induction of increased arterial rigidity.
D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology*; D003900:Desoxycorticosterone; D006439:Hemodynamics; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000494:pharmacology*; D017693:Sodium Bicarbonate; D014655:Vascular Resistance
D001639:Bicarbonates; D002712:Chlorides; D003900:Desoxycorticosterone; D017693:Sodium Bicarbonate; D012964:Sodium