[Effect of immunostimulants of steroidogenesis on the activity of various oxidative enzymes in the adrenal glands and other organs].
Effect of IgG from rabbits, immunized with deoxyribonucleoprotein and with nuclear matrix of rat adrenal glands, on activities of cytochrome c oxidase, glucose-6-phosphate (G6PD) and lactate (LDH) dehydrogenases was studied in rat adrenal glands, liver and spleen tissues, myocardial and skeletal muscles. After administration of the antibodies and deoxynucleoprotein activation of the oxidative enzymes was tissue-dependent. Activities of cytochrome c oxidase and G6PD were distinctly increased in adrenal glands. In other tissues studied the enzymatic activity was not either increased (spleen, myocardium, skeletal muscle) or mediated through adrenal glands (liver tissue). The tissue-dependent activation of the oxidative enzymes, which accompanied the steroidogenic effect of the immunoglobulins studied, was considered as a result of interaction between the antibodies and tissue-specific antigen determinants in adrenal gland chromatin.
D000302:Adrenal Cortex / Q000201:enzymology* / Q000276:immunology; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000502:physiology*; D000974:Antibodies, Antinuclear / Q000502:physiology; D003345:Corticosterone / Q000097:blood; D003576:Electron Transport Complex IV / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology; D007114:Immunization; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000502:physiology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D009132:Muscles / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000201:enzymology; D013256:Steroids / Q000096:biosynthesis*
D000906:Antibodies; D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G; D013256:Steroids; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D003576:Electron Transport Complex IV; D003345:Corticosterone; D006854:Hydrocortisone
Vliianie immunologicheskikh stimuliatorov steroidgeneza na aktivnost' nekotorykh okislitel'nykh fermentov v nadpochechnikakh i drugikh organakh.