Metastatic epidural osteosarcoma initially diagnosed as cisplatin neuropathy.
Unexpected early epidural spinal metastasis in a case of osteosarcoma occurred in a patient receiving treatment with cis-diamminedichloroplatinum-II (cisplatin). The initial neurologic symptomatology manifested as paresthesias in the feet which developed 2 months after initiation of treatment (cumulative dose of cisplatin 450 mg/M2) at which stage the primary tumor demonstrated a marked response. Concurrently two small pulmonary metastases appeared. Epidural metastasis in osteosarcoma is generally considered a late complication and is usually associated with disseminated disease. This communication draws attention to changes in the metastatic pattern which may occur with the administration of seemingly effective treatment and the potential for confusing the symptomatology of epidural spinal metastasis with cisplatin neuropathy.
D000293:Adolescent; D002945:Cisplatin / Q000009:adverse effects*; D003951:Diagnostic Errors; D004824:Epidural Space; D006801:Humans; D008297:Male; D009192:Myelography; D012516:Osteosarcoma / Q000175:diagnosis* / Q000556:secondary; D010292:Paresthesia / Q000139:chemically induced; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000175:diagnosis*; D013117:Spinal Cord Compression / Q000175:diagnosis*
D002945:Cisplatin