[Pharmacological analysis of the participation of the catecholaminergic system in the development of the abstinence syndrome in rats].
The behavioural activity of rats in "the open field" was studied. It was revealed that rats alcoholized for 8 months do not practically differ in their behavioural indicators from the intact ones. After the discontinuation of alcohol marked disturbances appear in their behaviour, that are arrested by apomorphine (0,1 mg/kg). In intact animals dopamine (50 mkg into the brain ventricles) induces behavioural disorders similar to those in rats during abstinence. Noradrenaline does not induce similar disorders. A conclusion is made on the dopaminergic nature of disorders in the behaviour of rats in the state of alcohol abstinence.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology; D000431:Ethanol / Q000009:adverse effects*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D017983:Receptors, Catecholamine; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D013997:Time Factors
D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine; D000431:Ethanol; D001058:Apomorphine; D004298:Dopamine; D009638:Norepinephrine
Farmakologicheskiĭ analiz uchastiia katekholaminergicheskoĭ sistemy v razitii abstinentnogo sindroma u krys.