Data to the intracellular effects of prostacyclin in rat gastric mucosa.
Using specific radioimmunoassay it seems that Prostacyclin has a strong effect on the cyclic nucleotide-content of the rat gastric antral mucosa. Shortly (1 min) after an intragastric application of 100 micrograms/kg Prostacyclin the cAMP and the cGMP-content showed a significant decrease. Investigating the antral and fundic mucosal calmodulin-levels, it seems that 15-30 mins after Prostacyclin application both tend to increase. It seems very probable that the primary intracellular effect of Prostacyclin in the gastric mucosa is directed to the so-called 'second messenger system' but later Prostacyclin activates the calmodulin-system too.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D011464:Epoprostenol / Q000494:pharmacology*; D005748:Gastric Fundus / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D011706:Pyloric Antrum / Q000187:drug effects / Q000378:metabolism; D051381:Rats
D011464:Epoprostenol; D000242:Cyclic AMP; D006152:Cyclic GMP