Effects of certain CNS depressants and verapamil on cGMP in the cerebellum of rats.
The influence, individually and in combination, of certain general CNS depressants, Ca+2, A23187, and verapamil on rat cerebellar cGMP was studied. When Ca+2 was given to rats treated with ethanol, ether, or pentobarbital a minor increase in cGMP resulted. However, A23187 alone, or with Ca+2 did not produce a rise in cGMP levels in the presence of those drugs. A similar effect was seen with verapamil. Increasing doses of pentobarbital with verapamil enhanced the inhibition of cGMP.
D000818:Animals; D002122:Calcium Chloride / Q000494:pharmacology; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D002531:Cerebellum / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004347:Drug Interactions; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000494:pharmacology*
D002492:Central Nervous System Depressants; D014700:Verapamil; D006152:Cyclic GMP; D002122:Calcium Chloride