[Ceruloplasmin activity and content of the blood of persons with acute and chronic alcoholic intoxication].
The concentrations of the enzymatically active and immunoreactive ceruloplasmin (CP) were determined in the blood serum of healthy men by means of the spectrophotometric and immuno-electro-photometric methods. Part of the total (immunoreactive) CP (15%), circulated in the blood channel in an enzymatically inactive state. The increase of the time of suffering from chronic alcoholism from 1 to 29 years leads to the growth of the concentrations of CP possessing enzymatic activity and of immunoreactive CP. The share of the enzymatically inactive protein remains practically constant. During acute alcohol intoxication there is a temporal drop of the C1 share in enzymatically active state with a constant concentration of the total protein in the blood serum.
D000293:Adolescent; D000328:Adult; D000435:Alcoholic Intoxication / Q000097:blood*; D000437:Alcoholism / Q000097:blood*; D002570:Ceruloplasmin / Q000032:analysis / Q000276:immunology / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D007122:Immunoelectrophoresis; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D002570:Ceruloplasmin
Aktivnost' i soderzhanie tseruloplazmina v krovi liudeĭ pri ostroĭ i khronicheskoĭ alkogol' noĭ intoksikatsii.