Glomerular basement membrane splitting and microaneurysm formation associated with nitrosourea therapy.
A patient who developed renal insufficiency following nitrosourea therapy is reported. Light, immunohistochemical, and electron microscopic studies of the renal biopsy disclosed an unusual glomerular basement membrane injury. Light microscopy showed extensive basement membrane splitting and capillary aneurysm formation. Electron microscopic examination revealed an extensive subendothelial accumulation of electron-lucent granular material. The glomerular basement membrane was separated from the mesangium and showed splitting of the lamina densa. Immunofluorescent and immunoperoxidase staining of the glomeruli was negative for immunoglobulin, complement, and fibrinogen. This form of nitrosourea-associated glomerular injury has not been described previously.
D007516:Adenoma, Islet Cell / Q000188:drug therapy; D000783:Aneurysm / Q000139:chemically induced* / Q000473:pathology; D001485:Basement Membrane / Q000187:drug effects / Q000648:ultrastructure; D002196:Capillaries / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009607:Nitrosourea Compounds / Q000009:adverse effects*; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D013311:Streptozocin / Q000009:adverse effects / Q000031:analogs & derivatives
D009607:Nitrosourea Compounds; C007028:chlorozotocin; D013311:Streptozocin