title: Age-dependent complementation of the B (MHC) alleles and a non-B allele controlling resistance to progression of Rous sarcomas, and genetic independence of resistance to induction of tumours in the model of inbred lines of chickens.
abstract: The effect of age on the resistance to progression of Rous sarcomas was investigated in chickens of different inbred lines and their hybrids. This genetic resistance depends on complementation of B-linked genes and complementation of genes outside the B complex. The reduction of tumour inducibility is controlled by genes outside the B complex, and this type of resistance is independent of the resistance to tumour progression that is primarily controlled by B-linked genes.
mesh_terms: D000375:Aging; D000483:Alleles; D000818:Animals; D001358:Avian Sarcoma Viruses; D002645:Chickens / Q000235:genetics / Q000276:immunology*; D005802:Genes, MHC Class II; D005816:Genetic Complementation Test; D007178:Inbreeding; D008285:Major Histocompatibility Complex; D001357:Sarcoma, Avian / Q000235:genetics / Q000276:immunology*