[HTLV-III in persons with intravenous drug abuse. Correlation of antibodies against HTLV-III with neopterin and TH/TS].
Antibodies against HTLV-III, neopterin levels in blood and urine, TH/TS ratio and hepatitis marker were determined in 34 clinically symptom-free persons known to be intravenous drug abusers. 15 persons were positive in the ELISA and Western-blot tests. There was a strong reaction to protein p24 compared with that to protein p41. In 12 of 14 persons who were antibody-positive the neopterin level in morning urine was elevated; an abnormal TH/TS ratio was present in nine of 13 persons. In future, determination of neopterin and of antibodies against certain proteins of HTLV-III may make it possible to provide a simple way of prognosticating on the course of an HTLV-III infection.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000382:microbiology; D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood / Q000652:urine; D017977:Deltaretrovirus / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects / Q000295:instrumentation; D008297:Male; D009294:Narcotics / Q000008:administration & dosage; D019798:Neopterin; D009293:Opioid-Related Disorders / Q000276:immunology*; D012306:Risk; D013594:Syringes
D000914:Antibodies, Viral; D009294:Narcotics; D001708:Biopterins; D019798:Neopterin
HTLV-III-Durchseuchung bei Personen mit intravenösem Drogenmissbrauch. Korrelation von Antikörpern gegen HTLV-III mit Neopterin und TH/TS.