SAR of the effect of endotoxin on serum angiotensin converting enzyme in the mouse.
Administration of intact lipopolysaccharide from E. coli and S. minnesota to mice produced a lowering of serum angiotensin converting enzyme (ACE). However, when either lipid A or carbohydrate-free endotoxin from S. minnesota-Re595 was administered, a rise in serum ACE occurred. A possible explanation for these respective effects may be related to an indirect effect on lung perfusion, on the one hand, or a direct toxic effect to endothelial cell membranes, on the other.
D000818:Animals; D004731:Endotoxins / Q000494:pharmacology*; D008050:Lipid A / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D013329:Structure-Activity Relationship
D004731:Endotoxins; D008050:Lipid A; D008070:Lipopolysaccharides; D007703:Peptidyl-Dipeptidase A