title: Endogenous benzodiazepine receptor agonist in human and mammalian plasma.
abstract: Using ultra-filtration steps and HPLC-separation, a low molecular weight ligand of the benzodiazepine receptor was isolated from plasma of various mammalian species including man. The endogenous ligand acts on benzodiazepine receptors agonistically and apparently has a receptor affinity similar to Diazepam. The ligand is not identical with Diazepam as indicated by HPLC and UV-spectroscopy.
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D002851:Chromatography, High Pressure Liquid; D003975:Diazepam / Q000378:metabolism; D006801:Humans; D008024:Ligands / Q000097:blood; D011817:Rabbits; D011869:Radioligand Assay; D051381:Rats; D011963:Receptors, GABA-A / Q000032:analysis / Q000378:metabolism*; D013045:Species Specificity; D013552:Swine
chemical_list: D008024:Ligands; D011963:Receptors, GABA-A; D003975:Diazepam