title: Regulation of the manganese-containing superoxide dismutase is independent of the inducible DNA repair system in Escherichia coli.
abstract: Studies on the induction of the manganese-containing superoxide dismutase in several strains of Escherichia coli with different mutations in recA and lexA revealed that the inductions of the Mn-isozyme and of the SOS system by oxygen free radicals are not coregulated. We also studied the synthesis of the manganese-superoxide dismutase in the temperature-dependent, protease-constitutive strain recA441(tif-1) that also contained a lac fusion in an SOS gene. A shift to the temperature at which recA441 has constitutive protease activity did not induce Mn-superoxide dismutase but did induce beta-galactosidase. The data clearly demonstrate that induction of the Mn-superoxide dismutase is independent of the SOS system.
mesh_terms: D004260:DNA Repair / Q000187:drug effects; D004790:Enzyme Induction; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D005609:Free Radicals; D005798:Genes, Bacterial; D005809:Genes, Regulator; D007527:Isoenzymes / Q000096:biosynthesis* / Q000235:genetics; D008345:Manganese / Q000378:metabolism*; D009154:Mutation; D010269:Paraquat / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000096:biosynthesis* / Q000235:genetics; D013481:Superoxides / Q000494:pharmacology
chemical_list: D005609:Free Radicals; D007527:Isoenzymes; D013481:Superoxides; D008345:Manganese; D013482:Superoxide Dismutase; D010269:Paraquat