Effect of forphenicinol on gamma-interferon production in mice sensitized with BCG.
Forphenicinol stimulated the production of BCG-induced gamma-interferon in BCG-sensitized mice as much as 11-fold whereas it did not induce interferon production in unsensitized mice. This stimulatory effect was also observed in mice immuno-suppressed by cyclophosphamide. Furthermore, BCG-induced gamma-interferon production was reduced in mice by treatment with an anti-macrophage agent (silica gel), and forphenicinol administration into such mice could augment their interferon production. Transplantation of macrophages from forphenicinol-treated mice into mice injected with silica gel remarkably enhanced the BCG-induced interferon production in the recipients. These results suggest that the stimulatory effect of forphenicinol on BCG-induced gamma-interferon production in mice was due to the activation of macrophages.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001500:BCG Vaccine / Q000276:immunology*; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007114:Immunization; D007371:Interferon-gamma / Q000096:biosynthesis*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008813:Mice, Inbred ICR; D012822:Silicon Dioxide / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D000903:Antibiotics, Antineoplastic; D001500:BCG Vaccine; C035946:forphenicinol; D012822:Silicon Dioxide; D007371:Interferon-gamma; D003520:Cyclophosphamide; D005998:Glycine