Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788.
The imidazodiazepine Ro 15-1788 is a benzodiazepine receptor antagonist that was initially reported to be lacking in intrinsic activity in a variety of test situations in which benzodiazepine-like effects can be identified. However, many recent studies have shown that this compound does indeed have intrinsic activity in a variety of behavioural, neurological, electrophysiological and biochemical preparations in both animals and man. The purpose of the present review is firstly to describe these intrinsic actions, and secondly to consider to what extent these intrinsic actions of Ro 15-1788 have implications for current concepts of the functioning of the benzodiazepine receptor.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D000927:Anticonvulsants; D001007:Anxiety / Q000503:physiopathology; D001362:Avoidance Learning / Q000187:drug effects; D001570:Benzodiazepinones / Q000494:pharmacology* / Q000627:therapeutic use; D001831:Body Temperature / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D004192:Discrimination, Psychological / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004558:Electric Stimulation; D005106:Exploratory Behavior / Q000187:drug effects; D005442:Flumazenil; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D009043:Motor Activity / Q000187:drug effects; D011963:Receptors, GABA-A / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D013315:Stress, Psychological / Q000378:metabolism
D000927:Anticonvulsants; D001570:Benzodiazepinones; D011963:Receptors, GABA-A; D005442:Flumazenil