Preparation of [99mTc(DMPE)2Cl2]+ for myocardial imaging by using Fe-(DMPE) complexes.
The preparation of [99mTc(1,2-bis(dimethylphosphino)ethane)2Cl2]+ ([99mTc(DMPE)2Cl2]+) for imaging the myocardium is investigated. Starting from Fe(III)- or Fe(II)-DMPE and 99mTcO4- different preparation variants are compared. In these reactions either ascorbic acid or DTPA serves as an agent for complexing iron. A simple procedure using lyophilized initial components is represented. Its application yields [99mTc(DMPE)2Cl2]+ with a radiochemical purity of more than 95%. Organ distribution studies performed in rats emphasize the high myocardial accumulation of this preparation.
D000818:Animals; D006321:Heart / Q000000981:diagnostic imaging; D006863:Hydrogen-Ion Concentration; D007501:Iron; D007553:Isotope Labeling; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D010720:Phosphines / Q000378:metabolism; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium / Q000378:metabolism; D014018:Tissue Distribution
D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D010720:Phosphines; D013667:Technetium; C031898:technetium Tc 99m bis(1,2-dimethylphosphino)ethane; C050346:iron bis(1,2-dimethylphosphino)ethane complex; D007501:Iron