Chronic inflammatory demyelinating polyneuropathy of infancy: a corticosteroid-responsive disorder.
We present the clinical, electrophysiological, and histopathological findings in 6 children with early-onset chronic inflammatory demyelinating neuropathy. The clinical features initially suggested a genetically determined disorder in each patient. Sural nerve biopsy showed changes of chronic demyelination with multifocal endoneurial edema and mononuclear cellular infiltrates. All children improved with corticosteroid therapy.
D002675:Child, Preschool; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis*; D011241:Prednisone / Q000627:therapeutic use*
D011241:Prednisone