Detection and localization of the v-myb(AMV) gene products of avian myeloblastosis virus by a synthetic peptide antiserum.
An antiserum made against a synthetic peptide from an internal region of the predicted amino acid sequence of the avian myeloblastosis virus (AMV) transforming v-myb(AMV) gene identified two products, p46v-myb(AMV) and p32v-myb(AMV), which were localized in the nucleus of AMV-transformed myeloblasts. We propose that these proteins are the in vivo products of the v-myb(AMV) gene and thus the transforming protein(s) of AMV.
D000818:Animals; D001354:Avian Leukosis Virus / Q000235:genetics*; D009189:Avian Myeloblastosis Virus / Q000235:genetics* / Q000276:immunology; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism; D002645:Chickens; D005814:Genes, Viral; D008970:Molecular Weight; D009856:Oncogene Proteins, Viral / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D009857:Oncogenes; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology; D011487:Protein Conformation; D012995:Solubility
D009856:Oncogene Proteins, Viral; D010455:Peptides