Application of immune adherence hemagglutination test in the screening of blood donors carrying a high titer antibody to varicella-zoster virus.
The immune adherence hemagglutination (IAHA) test was compared with the complement fixation (CF) test and fluorescent antibody (FA) test to measure the antibody titer to varicella-zoster virus (VZV) in 70 sera of convalescents 2 to 8 weeks after herpes zoster onset. The IAHA titer correlated with the FA titer, but not with the CF titer which was lower than the IAHA and FA titers. Then, the IAHA test was used for screening of blood donors with a high titer (higher than 64 units) of antibody to VZV from 2,592 blood donors. About 14% of the sera from the donors aged 16 to 19 years had an antibody titer higher than 64 units, about 10% of sera from the donors aged 20 to 49 years, and 5.6% of sera from the donors older than 50 years. An average positive rate was about 9%, indicating that an enough VZV immune plasma with a high titer of antibody might be obtained from blood donors.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D001782:Blood Donors; D003168:Complement Fixation Tests; D005260:Female; D005455:Fluorescent Antibody Technique; D006386:Hemagglutination Tests; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged
D000914:Antibodies, Viral