Down-regulation of testicular follicle-stimulating hormone receptors by human menopausal gonadotropin in infertile men.
We measured testicular FSH receptors in 27 infertile men before, or 1, 3, 5, 7, or 14 days after a single administration of 150 IU of hMG. The administration of hMG reduced Bmax for FSH receptors to about 50% of that in the preadministration testes for 5 days. From the seventh day, Bmax of FSH receptors began to increase and returned to the preadministration level 14 days after the administration.
D001665:Binding Sites; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy*; D007700:Kinetics; D008297:Male; D008596:Menotropins / Q000627:therapeutic use*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011962:Receptors, FSH; D013737:Testis / Q000378:metabolism*; D013997:Time Factors
D011956:Receptors, Cell Surface; D011962:Receptors, FSH; D008596:Menotropins; D005640:Follicle Stimulating Hormone