Vasopressin inhibition of cyclic AMP accumulation and effects on the learned response in inbred mouse strains.
The effects of a single injection of arginine vasopressin on the cyclic AMP responses of cerebral cortex slices to noradrenaline, forskolin and 2-chloro-adenosine were tested in six inbred mouse strains. The noradrenaline response was reduced in one strain and that to 2-Cl-adenosine in 2 strains. There was a positive correlation between the differences in the cyclic AMP response to 2-Cl-adenosine between control and AVP-treated mice and the differences in latencies during the extinction period of conditioned avoidance response learning.
D015762:2-Chloroadenosine; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D005576:Colforsin / Q000494:pharmacology; D003213:Conditioning, Psychological / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D009638:Norepinephrine / Q000494:pharmacology; D013045:Species Specificity
D001127:Arginine Vasopressin; D015762:2-Chloroadenosine; D005576:Colforsin; D000242:Cyclic AMP; D000241:Adenosine; D009638:Norepinephrine