[Significance of endocrine parameters of stress].
Thirty two male patients undergoing coronary bypass surgery were given low (group A, 0.01 mg/kg bw) and high dose (group B, 0.035 mg/kg bw) fentanyl anaesthesia. Haemodynamic and hormone responses were investigated from the beginning of anaesthesia until extracorporeal circulation (ECC) (group A: n = 16; group B: n = 16). Significant changes in haemodynamics occurred only in group A including an increase in heart rate (36%) and systolic arterial pressure (21%). Plasma vasopressin (ADH) levels rose significantly in both groups after the beginning or surgical procedure which was markedly less pronounced in patients with high fentanyl (group B). In group A (low dose) a second dose of fentanyl was given after sternotomy, which was followed by a significant decrease in ADH (80% from previous value). No significant variations could be demonstrated in plasma levels of cortisol, ACTH, and human growth hormone (HGH). The data stress the importance of plasma-vasopressin-levels in determining the endocrine stress response following trauma and operation. On the other hand there was a lack of correlation between trauma and pain and frequently reported patterns of the endocrine-metabolic stress response.
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D000768:Anesthesia, General; D002986:Clinical Trials as Topic; D001026:Coronary Artery Bypass; D005283:Fentanyl / Q000008:administration & dosage; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000097:blood / Q000453:epidemiology; D011446:Prospective Studies; D011897:Random Allocation; D013312:Stress, Physiological / Q000097:blood*; D014667:Vasopressins / Q000097:blood*
D014667:Vasopressins; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D005283:Fentanyl; D006854:Hydrocortisone
Wertigkeit endokriner Stress-Parameter.