In vitro cytotoxicity and antibiotic activity of polymyxin B nonapeptide.
Polymyxin B nonapeptide, prepared by enzymic removal of the fatty acyl diaminobutyric acid side chain from polymyxin B, was about 100-fold less toxic to K562 cells than polymyxin B. MICs of polymyxin B nonapeptide against a test panel of bacteria were 2- to 64-fold lower than those of polymyxin B.
D001419:Bacteria / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011112:Polymyxin B / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D011113:Polymyxins / Q000494:pharmacology*
D011113:Polymyxins; C038934:polymyxin B nonapeptide; D011112:Polymyxin B