Regional increase of cyclic GMP by atrial natriuretic factor in rat brain: markedly elevated response in spontaneously hypertensive rats.
Atrial natriuretic factor (ANF)-responsive areas in rat brain were examined by measuring ANF-stimulated cyclic GMP production in rat brain slice preparations. The medulla oblongata, thalamus, and pituitary gland responded most sensitively, the septum, hypothalamus, pons, midbrain and olfactory bulb responded moderately, but neocortex, cerebellum, striatum and hippocampus were unresponsive to ANF. The most responsive regions in spontaneously hypertensive rats brains showed 2 to 5 times higher cyclic GMP production than those from the control Wistar-Kyoto rats. These findings provide evidence for biological action of ANF on brain tissues, and indicate the action of ANF produced in the brain.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D006152:Cyclic GMP / Q000032:analysis*; D004305:Dose-Response Relationship, Drug; D007031:Hypothalamus / Q000032:analysis / Q000187:drug effects; D008297:Male; D008526:Medulla Oblongata / Q000032:analysis / Q000187:drug effects; D010902:Pituitary Gland / Q000032:analysis / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*; D011921:Rats, Inbred WKY; D013788:Thalamus / Q000032:analysis / Q000187:drug effects
C472610:atrial natriuretic peptide, rat; D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP