[Low early mortality after allogeneic bone marrow transplantation thanks to rigorous sterility measures, modified whole body irradiation, cyclosporin A and antiviral precautions].
A heterogeneous group of 20 consecutive patients was treated according to a standardized allogeneic marrow transplantation protocol designed to reduce early posttransplant lethality. In spite of the fact that 13 patients had at least one (10 of them 2-3) risk factors related to high early lethality, only 2 early transplantation-associated deaths occurred (1 GvH, 1 int. pneumonia). The low incidence of GvH II-IV and interstitial pneumonia, as well as the absence of lethal infections observed in our small patient group, is presumed to be due to the rigorous isolation/decontamination conditions, the reduction of radiation toxicity and GvH prophylaxis by cyclosporin A.
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy*; D016026:Bone Marrow Transplantation; D002648:Child; D003524:Cyclosporins / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000517:prevention & control; D004203:Disinfection; D004780:Environment, Controlled; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D014916:Whole-Body Irradiation
D003524:Cyclosporins
Geringe Frühletalität nach allogener Knochenmarktransplantation dank konsequenter Sterilpflege, modifizierter Ganzkörperbestrahlung, cyclosporin A und antiviraler Prophylaxe.