Biodistribution in rats of 99Tcm-labelled human serum albumin.
Three different 99Tcm-human serum albumin (HSA) preparations were simultaneously studied by high pressure liquid chromatography (HPLC) and gamma camera techniques in rats. The products contained variable amounts of 99Tcm-human albumin, 99Tcm-tin colloid and a 99Tcm-low molecular weight complex. The biological half life varied from 55 to 132 min and the bladder excretion for the first 60 min from 2 to 31%. Separated HPLC fractions of 99Tcm-albumin and 99Tcm-tin colloid both showed considerably longer biological half life when injected separately than when injected in the unfractionated preparation. A final evaluation of the quality of such products seem to require evaluation in humans.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006207:Half-Life; D006801:Humans; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains; D012711:Serum Albumin, Radio-Iodinated / Q000378:metabolism*; D013670:Sodium Pertechnetate Tc 99m / Q000378:metabolism; D013667:Technetium / Q000378:metabolism*; D017556:Technetium Compounds; D014001:Tin / Q000378:metabolism; D017971:Tin Compounds; D014018:Tissue Distribution
D012711:Serum Albumin, Radio-Iodinated; D017556:Technetium Compounds; D017971:Tin Compounds; C033493:technetium Tc 99m tin colloid; C023599:stannous chloride; D013667:Technetium; D014001:Tin; D013670:Sodium Pertechnetate Tc 99m