[Comparative study of the effectiveness of acycloguanosine and phosphonoacetic acid in herpetic infection in cell cultures].
A comparative study of cytotoxicity and antiherpes activity of acycloguanosine (Acg) of the Soviet and American manufacture and a Soviet preparation of phosphonoacetic acid (PAA) for herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) was carried out in primary and continuous cell cultures. The Acg preparation was shown not to be inferior in maximal tolerated concentration, minimal inhibiting concentration, and chemotherapeutic index (CTI) to American drug. Zovirax (Zvr), in relation to both herpes simplex virus types in primary and continuous cell lines. The CTI of Acg and Zvr was 25-30-fold higher than that of PAA for HSV-1 (Vero cells) and 80-fold higher in chick embryo fibroblast cultures (CEF), and 25-fold higher for HSV-2 in CEF.
D000212:Acyclovir / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D002642:Chick Embryo; D004353:Drug Evaluation, Preclinical; D006561:Herpes Simplex / Q000188:drug therapy*; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D010746:Phosphonoacetic Acid / Q000627:therapeutic use* / Q000633:toxicity; D018139:Simplexvirus / Q000187:drug effects; D014776:Virus Cultivation
D009943:Organophosphorus Compounds; D010746:Phosphonoacetic Acid; D000212:Acyclovir
Sravnitel'noe izuchenie éffektivnosti atsikloguanozina i fosfonouksusnoĭ kisloty pri gerpeticheskoĭ infektsii v kul'turakh kletok.