title: Homology between exon-containing portions of rabbit genomic clones for synovial cell collagenase and human foreskin and synovial cell mRNAs.
abstract: Portions of rabbit genomic clones containing exons cross-hybridize with human synovial cell and human foreskin fibroblast mRNAs. These cross-hybridizing genomic fragments have been subcloned into pBR328 and may be useful probes in isolating cDNA and genomic clones from human tissue, and perhaps from other species as well. In addition, DNA sequence data on a 530 bp cDNA clone for rabbit synovial-cell collagenase indicate that this clone is composed primarily of 3'-untranslated region. As such, it is probably not useful in cross-species hybridizations.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis; D004262:DNA Restriction Enzymes; D005091:Exons; D005796:Genes; D006801:Humans; D008297:Male; D003012:Microbial Collagenase / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000235:genetics*; D011817:Rabbits; D012689:Sequence Homology, Nucleic Acid; D012867:Skin / Q000201:enzymology*; D013582:Synovial Fluid / Q000201:enzymology*
chemical_list: D012333:RNA, Messenger; D004247:DNA; D004262:DNA Restriction Enzymes; D003012:Microbial Collagenase