Oculopharyngeal muscular dystrophy: recent ultrastructural evidence for mitochondrial abnormalities.
Oculopharyngeal muscular dystrophy is a rare, autosomal dominant disorder which has been traced through 11 generations of a French Canadian family. The classic presenting complaints are palpebral ptosis and oropharyngeal dysphagia. The dysphagia is usually progressive and leads to repetitive regurgitation, increased alimentation time, and weight loss. Immunologic studies generally reveal elevated levels of IgA and IgG, while manometry demonstrates poor pharyngeal contraction. The dysphagia is frequently relieved by cricopharyngeal myotomy. We present two case reports and also a new ultrastructural finding of abnormal metallic mitochondrial inclusions. This finding has not been previously described in this disorder.
D000328:Adult; D000368:Aged; D001763:Blepharoptosis / Q000235:genetics / Q000473:pathology; D003680:Deglutition Disorders / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000648:ultrastructure*; D009132:Muscles / Q000473:pathology / Q000601:surgery / Q000648:ultrastructure; D009136:Muscular Dystrophies / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D010375:Pedigree; D010609:Pharyngeal Muscles / Q000473:pathology / Q000648:ultrastructure