title: [Dependence of Na, K-ATPase enzyme activity on the surface properties and charge of the substances interacting with the cell membrane].
abstract: The surface activity and effect of histone, sodium deoxycholate and Triton X-100 on N+,K+-ATPase have been compared. It has been found that the coefficient of surface tightness on the borderline of suspension of ATPase containing membranes/air decreases with the increase in concentrations of these agents. The enzyme activity undergoes biphasic modification increasing with lower and decreasing with higher concentrations of the agents. The effectiveness of the agents depends on the charge of their molecules. The mechanism of interaction between Na+,K+-ATPase and the above modifiers is discussed.
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology*; D003840:Deoxycholic Acid / Q000494:pharmacology; D003902:Detergents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004563:Electrochemistry; D006168:Guinea Pigs; D006657:Histones / Q000494:pharmacology; D066298:In Vitro Techniques; D017830:Octoxynol; D011092:Polyethylene Glycols / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013500:Surface Tension; D013535:Suspensions
chemical_list: D003902:Detergents; D006657:Histones; D013535:Suspensions; D003840:Deoxycholic Acid; D011092:Polyethylene Glycols; D017830:Octoxynol; D000254:Sodium-Potassium-Exchanging ATPase
vernacular_title: Zavisimost' fermentativnoĭ aktivnosti Na, K-ATFazy ot poverkhnostnykh svoĭstv i zariada vzaimodeĭstvuiushchikh s kletochnoĭ membranoĭ veshchestv.