[Structural polymorphism of the provirus integrated in the genome of mammalian cells transformed by Rous sarcoma virus].
The structural organization of integrated Rous sarcoma virus (RSV) genome in 8 different mammalian tumour cell lines has been studied. The different types of provirus rearrangements were found, e.g.: breakpoint mutations, deletions of RSV structural genes, elimination of the entire viral genome. The structural changes of proviruses appeared during long-term cultivation of tumour cell lines in vitro. The ability of transformed cells to produce complete infectious RSV correlate with the structural peculiarities of proviruses, although the tumorigenic properties of these cells are retained in all cases.
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000235:genetics*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D006224:Cricetinae; D003412:Cricetulus; D004262:DNA Restriction Enzymes; D005814:Genes, Viral; D011110:Polymorphism, Genetic; D051381:Rats; D011919:Rats, Inbred Strains
D004262:DNA Restriction Enzymes
Strukturnyĭ polimorfizm integrirovannogo provirusa v genome kletok mlekopitaiushchikh, transformirovannykh virusom sarkomy Rausa.