Adenosine potentiates the effects of LH and isoproterenol on luteal cells but not on isolated intact corpora lutea.
Adenosine potentiated the stimulatory effect of luteinizing hormone (LH) in a dose-dependent way on the production of cyclic AMP (cAMP) in isolated cells from heavily luteinized rat ovaries and from individual rat corpora lutea of various ages (2- and 5-day-old). Such an effect has earlier been reported only for cells from heavily luteinized ovaries (Behrman et al. 1983). A similar potentiating effect of adenosine was now seen on catecholamine-stimulated cAMP production in isolated cells from 2-day-old corpora lutea. Adenosine did not, however, potentiate LH- or catecholamine-stimulated cAMP production in isolated intact corpora lutea.
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D002469:Cell Separation; D002478:Cells, Cultured; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D003338:Corpus Luteum / Q000378:metabolism*; D000242:Cyclic AMP / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology*; D008184:Luteal Cells / Q000378:metabolism; D007986:Luteinizing Hormone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D006063:Chorionic Gonadotropin; D007986:Luteinizing Hormone; D000242:Cyclic AMP; D000241:Adenosine; D007545:Isoproterenol