[Acute erythroblastopenia disclosing homozygous beta-thalassemia. Role of parvovirus infection].
An acute, transient aplastic crisis in a 15-month old boy revealed the presence of homozygous beta-thalassaemia. The crisis was very likely due to a parvovirus infection, in view of the presence of specific IgM at the onset and of seroconversion to total antibodies. Later, requirements for transfusions were in favour of an intermediate type thalassaemia. The responsibility of the parvovirus is discussed in the light of recent data concerning the inhibitory action of this virus on bone marrow erythropoiesis.
D000208:Acute Disease; D000741:Anemia, Aplastic / Q000209:etiology*; D006720:Homozygote; D006801:Humans; D007223:Infant; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D013789:Thalassemia / Q000150:complications* / Q000235:genetics
Erythroblastopénie aiguë révélatrice d'une bêta-thalassémie homozygote. Rôle d'une infection à parvovirus.