Severe pancreatitis and fatty liver progressing to cirrhosis associated with Coxsackie B4 infection in a three year old with alpha-1-antitrypsin deficiency.
A 3-year-old girl in whom severe acute pancreatitis was associated with evidence of Coxsackie B4 virus infection was alpha-1-antitrypsin deficient. Lack of this modulator of proteolysis may have been responsible for her severe course. Fatty liver at presentation progressed to cirrhosis in the ensuing 18 months.
D002675:Child, Preschool; D003384:Coxsackievirus Infections / Q000209:etiology*; D029822:Enterovirus B, Human / Q000302:isolation & purification; D005234:Fatty Liver / Q000209:etiology*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000209:etiology*; D010195:Pancreatitis / Q000209:etiology*; D019896:alpha 1-Antitrypsin Deficiency