title: Recombinant DNA technology.
abstract: The advent of new techniques in the study of DNA has generated great interest among clinicians in their application to genetic disorders. These new techniques are outlined, and their application in the study of X-linked disorders, in particular X-linked retinitis pigmentosa (RP), is described. This concerns chiefly the use of probes in studying DNA sequences on a given chromosome and the basic principles which govern their application.
mesh_terms: D000483:Alleles; D001483:Base Sequence; D002874:Chromosome Mapping; D003434:Crossing Over, Genetic; D004262:DNA Restriction Enzymes / Q000378:metabolism; D004274:DNA, Recombinant; D004587:Electrophoresis, Agar Gel; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008540:Meiosis; D011110:Polymorphism, Genetic; D012174:Retinitis Pigmentosa / Q000235:genetics*; D012729:Sex Chromosome Aberrations; D014960:X Chromosome
chemical_list: D004274:DNA, Recombinant; D004262:DNA Restriction Enzymes