title: HPLC separated fractions of 99mTc(NaBH4)-HEDP as myocardial infarct imaging agents.
abstract: Component fractions of 99mTc(NaBH4)-HEDP mixtures, isolated by anion exchange high performance liquid chromatography (HPLC), have been evaluated as myocardial infarct imaging agents in two animal models. Results from both the isoproterenol-induced myocardial infarction model, and the heat-induced myocardial necrosis model, show that the several HPLC isolated components exhibit significantly different abnormal/normal heart uptake ratios. In addition, the HPLC isolated component of shortest chromatographic retention time exhibits a higher abnormal/normal heart uptake ratio than does 99mTc(Sn)-PyP, the current agent of choice for clinical myocardial infarct imaging.
mesh_terms: D000818:Animals; D001894:Borohydrides / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D012968:Etidronic Acid; D005260:Female; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium / Q000302:isolation & purification; D016698:Technetium Tc 99m Pyrophosphate; D014003:Tin Polyphosphates
chemical_list: D001894:Borohydrides; D004338:Drug Combinations; D014003:Tin Polyphosphates; C017742:technetium Tc 99m stannous pyrophosphate; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium; C025364:sodium borohydride; D012968:Etidronic Acid