Should nucleotide sequence analyzing computer algorithms always extend homologies by extending homologies?
Most computer algorithms used for comparing or aligning nucleotide sequences rely on the premise that the best way to extend a homology between the two sequences is to select a match rather than a mismatch. We have tested this assumption and found that it is not always valid.
D001483:Base Sequence; D003201:Computers; D004279:DNA, Viral / Q000032:analysis; D013539:Simian virus 40 / Q000235:genetics; D012984:Software
D004279:DNA, Viral