Confirmation of the close linkage between the loci for human apolipoproteins AI and AIV by the use of a cloned cDNA probe and two restriction site polymorphisms.
We have isolated a cDNA probe for human apolipoprotein AI (apoAI) and used two DNA polymorphisms detected by this probe to analyse the inheritance of the apoAI gene in families informative for apoAIV protein variants. We have thereby increased the lod score for this linkage from 3.01 to 6.32 at a recombination fraction of zero.
D000483:Alleles; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000235:genetics*; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; C022205:apolipoprotein A-IV; D004247:DNA; D004262:DNA Restriction Enzymes