[Ultrastructural changes in the autonomic interneuronal synapse during activation in the presence of acetylcholinesterase suppression].
Structural-functional reconstructions of the frog autonomic interneuronal synapsis have been studied at its activation with endogenic acetylcholine under conditions of acetylcholinesterase suppression. The investigation has been performed with preparations of isolated sympathetic trunk of Rana temporaria treated with armine (5 X 10(-6) M) and subjected to electrostimulation (5 imp/sec) up to a complete block of the synaptic transmission. Certain structural changes are revealed in the axo-somatic synapses, demonstrating an increased adhesive properties of the membranes, ("hatch-like" membranes, numerous submembranous aggregates, aggregates of the intercellular cleft and neuronal-glial contacts). In the terminals changed according to the "light type", with poorly manifested changes, light synaptic vesicles loose their spheric form, their diameter decreases. In the boutons with more intensive changes, the vesicles gradually change into the mass of cluster-floccular material. In the boutons with intensively manifested disorders in the ultrastructure, a complete destruction of the light vesicles is observed. The great part of the ganglionic neuron bodies changes according the "dark type". In their neuroplasm a great amount of subsuperficial cisterns of the endoplasmic reticulum and formation of powerful fasciculi of microfilaments are noted to appear.
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D001138:Armin / Q000494:pharmacology*; D007395:Interneurons / Q000648:ultrastructure; D008854:Microscopy, Electron; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D011896:Rana temporaria; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000648:ultrastructure*; D013569:Synapses / Q000187:drug effects / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000187:drug effects
D009943:Organophosphorus Compounds; D001138:Armin; D000109:Acetylcholine
Ul'trastrukturnye izmeneniia avtonomnogo mezhneĭronnogo sinapsa pri ego aktivatsii v usloviiakh podavleniia atsetilkholinésterazy.