title: Neuroleukin: a lymphokine product of lectin-stimulated T cells.
abstract: Neuroleukin is a lymphokine product of lectin-stimulated T cells that induces immunoglobulin secretion by cultured human peripheral blood mononuclear cells. Neuroleukin acts early in the in vitro response that leads to formation of antibody-secreting cells, but continued production of immunoglobulin by differentiated antibody-secreting cells is neuroleukin-independent. Although the factor is not directly mitogenic, cellular proliferation is a late component of the response to neuroleukin. Neuroleukin does not have B-cell growth factor (BCGF) or B-cell differentiation factor (BCDF) activity in defined assays. Neuroleukin-evoked induction of immunoglobulin secretion is both monocyte- and T-cell-dependent.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000502:physiology; D001853:Bone Marrow / Q000378:metabolism; D002460:Cell Line; D002478:Cells, Cultured; D017977:Deltaretrovirus / Q000235:genetics; D005956:Glucose-6-Phosphate Isomerase; D006133:Growth Substances / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007136:Immunoglobulins / Q000096:biosynthesis; D037102:Lectins / Q000494:pharmacology; D007938:Leukemia / Q000378:metabolism; D008222:Lymphokines / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D008223:Lymphoma / Q000378:metabolism; D051379:Mice; D011043:Pokeweed Mitogens / Q000494:pharmacology; D012689:Sequence Homology, Nucleic Acid; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology*
chemical_list: D006133:Growth Substances; D007136:Immunoglobulins; D037102:Lectins; D008222:Lymphokines; D011043:Pokeweed Mitogens; D005956:Glucose-6-Phosphate Isomerase