Interleukin 1 alpha mRNA in virus-transformed T and B cells.
IL-1 alpha cDNA clone was isolated from a T cell line infected by the human T lymphotropic retrovirus type-I (HTLV-I/ATLV). We found significant amounts of mRNA hybridizing to IL-1 alpha cDNA not only in HTLV-I-transformed T cells but also in Epstein-Barr Virus-transformed B cells. A part of IL-2 receptor inducing activity in Adult T cell leukemia (ATL) cell line seems to be due to IL-1 alpha.
D001402:B-Lymphocytes / Q000032:analysis*; D001483:Base Sequence; D002460:Cell Line; D002472:Cell Transformation, Viral; D004247:DNA / Q000032:analysis; D017977:Deltaretrovirus / Q000032:analysis; D007375:Interleukin-1 / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis*; D011971:Receptors, Immunologic / Q000096:biosynthesis; D015375:Receptors, Interleukin-2; D012191:Retroviridae Proteins / Q000032:analysis; D013601:T-Lymphocytes / Q000032:analysis*
D007375:Interleukin-1; D012333:RNA, Messenger; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D012191:Retroviridae Proteins; D004247:DNA