Ouabain-insensitive, halide-sensitive Tl+ uptake by canine iliac arteries.
Ouabain-insensitive Tl+ uptake by canine iliac arteries was studied. A significant fraction was halide-sensitive, with Br- substituting well for Cl-. The halide-sensitive component was inhibited by diuretics (MK196, bumetanide), PCMBS, low temperatures and external cations K+, Rb+. External but not internal Na+ was necessary for the uptake process. The process was not sensitive to disulphonic stilbenes. The halide-sensitive uptake appears to represent the operation of a (Na+/K+/Cl-)-cotransport process in arteries.
D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D002731:4-Chloromercuribenzenesulfonate / Q000494:pharmacology; D000818:Animals; D001965:Bromides / Q000494:pharmacology*; D002034:Bumetanide / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology*; D004285:Dogs; D007083:Iliac Artery / Q000378:metabolism*; D007189:Indans / Q000494:pharmacology; D008094:Lithium / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D012413:Rubidium / Q000494:pharmacology; D013696:Temperature; D013793:Thallium / Q000378:metabolism*
D001965:Bromides; D002712:Chlorides; D007189:Indans; D002034:Bumetanide; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; D010042:Ouabain; D002731:4-Chloromercuribenzenesulfonate; D008094:Lithium; D013793:Thallium; C013352:indacrinone; D012413:Rubidium; D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; D011188:Potassium