Epstein-Barr virus related central nervous system lymphoma in a child after renal transplantation.
In this report, we describe the development of a rapidly progressive Epstein-Barr virus (EBV) related cerebral lymphoma in an 11 year old girl, eight months after renal transplantation. No serological evidence for a persistent EBV infection was found, but Epstein-Barr nuclear antigen (EBNA) could be demonstrated in the tumor. The clinical course of our patient was different from EBV-related syndromes in renal transplanted patients described in previous reports. Furthermore, pathological investigations of the biopsy specimen and tumor cells obtained at necropsy revealed a discrepancy in light chain expression. The possibility that lymphoproliferative disorders represent multiclonal B cell lymphomas is discussed.
D000956:Antigens, Viral / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D001932:Brain Neoplasms / Q000209:etiology* / Q000276:immunology; D002051:Burkitt Lymphoma / Q000209:etiology* / Q000276:immunology; D002648:Child; D019309:Epstein-Barr Virus Nuclear Antigens; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D016030:Kidney Transplantation; D013997:Time Factors
D000956:Antigens, Viral; D019309:Epstein-Barr Virus Nuclear Antigens