Fingerprint inclusions in non-vacuolated lymphocytes in juvenile neuronal ceroid-lipofuscinosis.
Three patients afflicted with juvenile neuronal ceroid-lipofuscinosis (NCL) have been found to harbor fingerprint lipopigments in the absence of vacuoles in their lymphocytes, in contrast to the majority of juvenile NCL patients in whose lymphocytes lipopigments with fingerprint profiles are usually located within vacuoles. These three patients may belong to clinical subtypes of juvenile NCL: the first patient to an early juvenile or a transitional form, the two latter patients to a protracted form.
D000293:Adolescent; D000328:Adult; D002675:Child, Preschool; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D009472:Neuronal Ceroid-Lipofuscinoses / Q000473:pathology*