Reexamination of the efficacy of vaccination against mousepox.
Experiments were conducted to evaluate the efficacy of three strains of vaccinia virus, IHD-T, Lister and Wyeth, to immunize the BALB/cByJ mouse against infection with ectromelia virus. Mice vaccinated with any of the strains were protected for at least 12 weeks against clinically apparent disease when challenged with cage-mates infected with a virulent stain (NIH-79) of ectromelia virus. However, 4 to 8 weeks after vaccination mice were capable of transmitting virus to non-vaccinated cage-mates. The results are discussed within the context of the current practices for preventing and controlling ectromelia epizootics.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D004482:Ectromelia, Infectious / Q000517:prevention & control* / Q000635:transmission; D008297:Male; D051379:Mice; D011213:Poxviridae Infections / Q000517:prevention & control* / Q000662:veterinary*; D012376:Rodent Diseases / Q000517:prevention & control*; D014611:Vaccination; D014616:Vaccinia virus / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D014765:Viral Vaccines