[Effect of dalargin on the content of endorphins, leucine-enkephalin ACTH and corticosterone of the blood of stressed rats].
Stress caused by acute cysteamine duodenal ulcer was induced in Wistar male rats. All the endogenous opioides under study were involved in the stress-reaction mechanism. Protective dalargin (synthetic enkephalin analogue) administration revealed a tendency towards normalization of endorphin, L-enkephalin and ACTH blood levels.
D000208:Acute Disease; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D001202:Ascitic Fluid; D003345:Corticosterone / Q000097:blood*; D004353:Drug Evaluation, Preclinical; D004723:Endorphins / Q000097:blood*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000097:blood* / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D008297:Male; D010538:Peritonitis / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors; D014118:Toxins, Biological / Q000633:toxicity
D004723:Endorphins; D014118:Toxins, Biological; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D000324:Adrenocorticotropic Hormone; C040996:enkephalin-Leu, Ala(2)-Arg(6)-; D003345:Corticosterone
Vliianie dalargina na soderzhanie v krovi stressirovannykh krys éndorfinov, letsin-énkefalina, AKTG i kortikosterona.