Detection of HSV1 DNA by in situ hybridisation in human brain after immunosuppression.
Human brain cells were examined for the presence of herpes simplex virus type 1 (HSV1) DNA sequences by in situ hybridisation. Viral genome was detected in immunosuppressed patients with virological evidence of past HSV infection but not in immunosuppressed patients with no such evidence. In patients who had not been immunosuppressed, no HSV DNA sequences were detectable.
D001921:Brain / Q000382:microbiology; D001923:Brain Chemistry; D004279:DNA, Viral / Q000032:analysis*; D006566:Herpesviridae Infections / Q000378:metabolism; D006801:Humans; D007165:Immunosuppression Therapy; D007945:Leukemia, Lymphoid / Q000382:microbiology; D007951:Leukemia, Myeloid / Q000382:microbiology; D008854:Microscopy, Electron; D009693:Nucleic Acid Hybridization; D018139:Simplexvirus
D004279:DNA, Viral