A position effect on the expression of a tRNA gene mediated by the SIR genes in Saccharomyces cerevisiae.
The SIR genes of Saccharomyces cerevisiae are responsible for the position-dependent regulation of the a and alpha mating-type genes. Previous work by others has shown that the products of the SIR genes prevent the accumulation of stable transcripts of the a and alpha genes at HML and HMR. Results of this study establish that this regulation is a region-specific effect rather than a gene-specific effect since expression of a tRNA gene placed at HMR is repressed by the products of the SIR genes.
D004262:DNA Restriction Enzymes; D005800:Genes, Fungal; D049770:Genes, Mating Type, Fungal; D005809:Genes, Regulator; D005838:Genotype; D000072235:Mating Factor; D009693:Nucleic Acid Hybridization; D010455:Peptides / Q000235:genetics; D010641:Phenotype; D010957:Plasmids; D012343:RNA, Transfer / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*
D010455:Peptides; D000072235:Mating Factor; D012343:RNA, Transfer; D004262:DNA Restriction Enzymes