Experimental and clinical studies on the effects of synthetic muramyldipeptide derivatives on viral and opportunistic infections.
The efficacy of strearoyl-MDP derivatives, L18-MDP and MDP-Lys-18 against bacterial and viral infections in mice was examined. Both L18-MDP and MDP-Lys-L18 stimulated nonspecifically host-resistance against opportunistic infection with C. kutscheri in hydrocrotisone-treated mice against Sendai virus infection in mice.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D003354:Corynebacterium Infections / Q000188:drug therapy* / Q000276:immunology; D006854:Hydrocortisone / Q000494:pharmacology; D007113:Immunity, Innate / Q000187:drug effects; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010222:Parainfluenza Virus 1, Human; D018184:Paramyxoviridae Infections / Q000188:drug therapy* / Q000276:immunology; D013997:Time Factors
D000119:Acetylmuramyl-Alanyl-Isoglutamine; C036866:romurtide; D006854:Hydrocortisone