Long-term potentiation and depression in hippocampal slices.
Antidromic stimulation of hippocampal CA 1 cells, in the presence of Mg2+ to eliminate synaptic transmission and with a pattern of impulses which when applied via a synaptic pathway produced long-term potentiation, was found to decrease the response of the CA 1 cells to subsequent synaptic activation. It was found that stimulation via synapses with the same pattern of stimuli caused long-term potentiation in normal conditions but not in the presence of 25 mM Mg2+.
D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D006624:Hippocampus / Q000502:physiology*; D008274:Magnesium / Q000494:pharmacology; D051381:Rats; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
D008274:Magnesium