Hyperpigmentation, vitiligo, and Addison's disease.
Addison's disease is an uncommon disorder whose dermatologic manifestations range from vitiligo to hyperpigmentation. The association of adrenal autoantibodies and vitiligo has made the latter a possible cutaneous marker for an autoimmune cause. The other cutaneous marker, hyperpigmentation, is now more clearly understood on the basis of a prohormone common to both adrenocorticotrophic hormone (ACTH) and melanocyte-stimulating hormone (MSH).
D000224:Addison Disease / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000368:Aged; D006801:Humans; D006854:Hydrocortisone / Q000172:deficiency; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism; D010859:Pigmentation Disorders / Q000209:etiology*; D011333:Pro-Opiomelanocortin / Q000378:metabolism; D014820:Vitiligo / Q000209:etiology*
D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D006854:Hydrocortisone