Autophagy and lysosomal proteolysis in the liver.
Autophagy is defined as any process whereby cellular macromolecules destined for degradation gain access to the lysosomes. A review is presented on the physiological significance, mechanisms and regulation of autophagy in hepatocytes, concentrating on the issue of regulation. The article ends by discussing techniques available for future research.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001216:Asparagine / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D004837:Epinephrine / Q000502:physiology; D005934:Glucagon / Q000502:physiology; D005938:Glucocorticoids / Q000502:physiology; D005973:Glutamine / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D006867:Hydrolases / Q000378:metabolism; D007328:Insulin / Q000502:physiology; D007382:Intermediate Filaments / Q000502:physiology; D007737:Kynurenine / Q000378:metabolism; D008099:Liver / Q000166:cytology*; D008247:Lysosomes / Q000502:physiology*; D008566:Membranes / Q000502:physiology; D008954:Models, Biological; D010447:Peptide Hydrolases / Q000378:metabolism; D010587:Phagocytosis; D013974:Thyroxine / Q000502:physiology
D000596:Amino Acids; D005938:Glucocorticoids; D007328:Insulin; D005973:Glutamine; D007737:Kynurenine; D001216:Asparagine; D005934:Glucagon; D000242:Cyclic AMP; D006867:Hydrolases; D010447:Peptide Hydrolases; D013974:Thyroxine; D002118:Calcium; D004837:Epinephrine