title: Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene.
abstract: The primary structure of normal abl protein was determined by sequencing the coding region of its cDNA. abl contains two alternative 5' exons spliced to a common set of 3' exons to yield the two major abl RNA transcripts. These transcripts initiate in different promoter regions and give rise to proteins that vary in their N-termini. In the human cell line K562, abl is translocated from chromosome 9 to within the bcr gene on chromosome 22. Within the fused bcr-abl gene, abl exon II alternatively splices to two adjacent bcr exons. This phenomenon is seen in many patients with chronic myeloid leukemia.
mesh_terms: D000011:Abelson murine leukemia virus / Q000235:genetics*; D000595:Amino Acid Sequence; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D004247:DNA / Q000235:genetics; D005091:Exons; D005786:Gene Expression Regulation; D006801:Humans; D009052:Leukemia Virus, Murine / Q000235:genetics*; D007951:Leukemia, Myeloid / Q000235:genetics; D010677:Philadelphia Chromosome; D011401:Promoter Regions, Genetic; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes; D012326:RNA Splicing; D014178:Translocation, Genetic
chemical_list: D011518:Proto-Oncogene Proteins; D004247:DNA