Preliminary data on the encapsulation of biologically active materials in liposomes.
Multilamellar and unilamellar phospholipid liposomes were prepared and investigated as regards their properties and the capacity of encapsulating biologically active materials, such as CrO4-(2-)ions, basic dyes, proteins, DNA, as well as Sendai virus particles. The efficiency of encapsulation ranged from 10% for CrO4-(2-)ions to about 80% for toluidine blue; it was found to depend not only on the type of encapsulated material, but also on the method used for liposome preparation and on liposome composition.
D000818:Animals; D002417:Cattle; D002840:Chromates / Q000494:pharmacology; D002876:Chromosomes, Bacterial; D004269:DNA, Bacterial / Q000494:pharmacology; D004347:Drug Interactions; D004926:Escherichia coli; D006801:Humans; D008081:Liposomes / Q000302:isolation & purification / Q000494:pharmacology*; D008722:Methods; D008970:Molecular Weight; D010222:Parainfluenza Virus 1, Human; D011370:Proflavine / Q000494:pharmacology; D012709:Serum Albumin / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013974:Thyroxine / Q000494:pharmacology; D014048:Tolonium Chloride / Q000494:pharmacology
D002840:Chromates; D004269:DNA, Bacterial; D008081:Liposomes; D012709:Serum Albumin; D014048:Tolonium Chloride; D012710:Serum Albumin, Bovine; D011370:Proflavine; D013974:Thyroxine