Interaction of the antivirus agents remantadine and amantadine with lipid membranes and the influence on the curvature of human red cells.
Surface potential difference, conductance, and elasticity changes of bilayer lipid membranes induced by the antivirus drugs amantadine and remantadine were measured. An influence on the human erythrocyte shape was shown. Both drugs are stomatocytogenic. The adsorption at the cytoplasmatic membrane was electrophoretically proved. The heat-induced vesiculation is partly inhibited. No microvesicles were observed. Instead, large tails which did not detach from the cell body were seen. The general conclusion is that these amphiphilic adamantane derivatives are membrane agents which modify membrane interaction processes, possibly by influencing the bending properties.
D000218:Adamantane / Q000031:analogs & derivatives*; D000547:Amantadine / Q000494:pharmacology*; D004548:Elasticity; D004578:Electron Spin Resonance Spectroscopy; D004907:Erythrocyte Deformability / Q000187:drug effects*; D006801:Humans; D007425:Intracellular Membranes / Q000187:drug effects; D008563:Membrane Lipids / Q000378:metabolism*; D012299:Rimantadine / Q000494:pharmacology*; D013997:Time Factors
D008563:Membrane Lipids; D012299:Rimantadine; D000547:Amantadine; D000218:Adamantane