Primary hepatocellular carcinoma with hepatitis B virus-DNA integration in a 4-year-old boy.
The autopsy findings in a case of hepatocellular carcinoma with hepatitis B virus (HBV)-DNA integration in a Japanese boy, 4 years and 10 month of age, are reported. The boy was an HBV carrier born in a typical familial cluster of HBV infection in Japan. He had been asymptomatic until the sudden manifestation of the liver tumor. Histopathologic examination revealed a well-differentiated, adult-type hepatocellular carcinoma without hepatic cirrhosis. HBV-DNA sequences were detected in the tumor cell DNA by the Southern blot hybridization method. This is the youngest patient with hepatocellular carcinoma with HBV-DNA integration reported to date, suggesting that HBV may manifest its oncogenic properties after a shorter incubation period than generally believed.
D000956:Antigens, Viral / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000032:analysis* / Q000209:etiology / Q000235:genetics / Q000473:pathology; D002675:Child, Preschool; D004273:DNA, Neoplasm / Q000032:analysis*; D004279:DNA, Viral / Q000032:analysis*; D005815:Genetic Code; D006509:Hepatitis B / Q000150:complications / Q000473:pathology; D006515:Hepatitis B virus; D006801:Humans; D008113:Liver Neoplasms / Q000032:analysis* / Q000209:etiology / Q000235:genetics / Q000473:pathology; D008297:Male; D009693:Nucleic Acid Hybridization
D000956:Antigens, Viral; D004273:DNA, Neoplasm; D004279:DNA, Viral