title: Chromosomal localization of muscle nicotinic acetylcholine receptor genes in the mouse.
abstract: The chromosomal localization of the genes encoding the four subunits of muscle nicotinic receptor was determined by analyzing restriction fragment length polymorphisms between two mouse species Mus musculus domesticus (DBA/2) and Mus spretus (SPE). Analysis of the progeny of the interspecies mouse backcross (DBA/2 X SPE) X DBA/2 showed that the alpha-subunit gene cosegregates with the alpha-cardiac actin gene on chromosome 17, that the beta-subunit gene is located on chromosome 11, and that the gamma- and delta-subunit genes cosegregate and are located on chromosome 1.
mesh_terms: D000199:Actins / Q000235:genetics; D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D051379:Mice; D008811:Mice, Inbred DBA; D009115:Muridae; D009132:Muscles / Q000032:analysis*; D009693:Nucleic Acid Hybridization; D011110:Polymorphism, Genetic; D011978:Receptors, Nicotinic / Q000235:genetics*; D013045:Species Specificity
chemical_list: D000199:Actins; D011978:Receptors, Nicotinic; D004247:DNA; D004262:DNA Restriction Enzymes