[Prognostic significance of pathology in 3, 147 cases of colorectal cancer. National Cooperative Group on Pathology and Prognosis of Colorectal Cancer].
This paper analyses the pathological features and prognosis in 3,147 cases of colorectal carcinoma collected from thirteen colleges, institutes and hospitals. The results reveal: The mean 5 year survival rate of 3,147 cases of colorectal carcinoma is 50.21%. The age of patient, tumor location, size, gross typing, histologic classification, growth pattern, the depth of infiltration, the metastasis into lymph nodes, the lymphocyte infiltration and fibrous proliferation surrounding the cancer are all prognostic. The depth of infiltration and metastasis into lymph nodes are the chief determinant of prognosis. The prognosis is much better in cases without penetrating the musculature or prognosis. The prognosis is much better in cases without penetrating the musculature or metastasis into lymph nodes than otherwise. It is better in those with metastases into 1-2 2 lymph nodes than with 3 or more. The histological types reflect the biologic nature of the cancer, exercising the most decisive influence upon the prognosis. The various pathologic changes are all closely associated with it. There is much difference in prognosis among well, moderately and poorly differentiated adenocarcinomas (70.3%, 49.6% and 26.6%) whereas almost no difference exists among the different histologic types with the same degree of differentiation. This indicates that it is the cancer differentiation which plays the important role in the prognosis. 4. The immune response in the regional lymph nodes, the lymphocyte infiltration and fibrous proliferation surrounding the cancer reflect the immune status of the organism against the cancer and favorably affect the prognosis.
D002288:Adenocarcinoma, Mucinous / Q000473:pathology; D000231:Adenocarcinoma, Papillary / Q000473:pathology; D000328:Adult; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012004:Rectal Neoplasms / Q000473:pathology*