Arachidonic acid in psoriasis. Pathogenic role and pharmacological regulation.
AA and its derivatives are a family of potent mediators and regulators of inflammation. There are several pieces of evidence to suggest a pathophysiologic role of certain AA derivatives in psoriasis. The complexity of the pathways in the generation of LTs and other LO products suggests that carefully designed systems will be needed to establish the exact role of these compounds in the pathogenesis of diseases such as psoriasis, and to test the effects of pharmacological inhibitors.
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D005395:Fish Oils / Q000008:administration & dosage; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000378:metabolism; D007975:Leukotriene B4 / Q000378:metabolism; D015289:Leukotrienes; D008084:Lipoxygenase / Q000378:metabolism; D016859:Lipoxygenase Inhibitors; D011565:Psoriasis / Q000178:diet therapy / Q000209:etiology / Q000378:metabolism*; D013189:SRS-A / Q000378:metabolism; D012867:Skin / Q000378:metabolism
D001095:Arachidonic Acids; D005395:Fish Oils; D006893:Hydroxyeicosatetraenoic Acids; D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors; D013189:SRS-A; D007975:Leukotriene B4; D016718:Arachidonic Acid; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; C025984:15-hydroxy-5,8,11,13-eicosatetraenoic acid; C025348:arachidonic acid 5-hydroperoxide; D008084:Lipoxygenase