[Radiation-induced free radicals in DNA, DNA level in tissues and tissue radiosensitivity].
Radiochemical yields (G-values) of H-adducts of thymine bases of DNA (TH) in frozen (77 K) gamma-irradiated mouse and rat tissues were measured. The content of DNA and the number of TH radicals formed in DNA mass of 10(12)D at a dose of 1 Gy (beta parameter) were determined for each of the studied tissue. It was shown that beta parameter, which indicated DNA in situ radiosensitivity, was different for different tissues: it was higher for radiosensitive tissues. The possible causes of the effect observed are discussed.
D000818:Animals; D004247:DNA / Q000378:metabolism / Q000528:radiation effects*; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D005720:Gamma Rays; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D011836:Radiation Tolerance; D051381:Rats; D014018:Tissue Distribution
D005609:Free Radicals; D004247:DNA
Radiatsionno-indutsirovannye svobodnye radikaly DNK, soderzhanie DNK v tkaniakh i tkanevaia radiochuvstvitel'nost'.