[Detection and significance of HBsAg associated receptors for polymerized human serum albumin in acute hepatitis B virus infection].
Receptors for polymerized human serum albumin (R-pHSA) may play a role in the attachment of hepatitis B virus (HBV) to hepatocytes. Therefore, we evaluated the incidence and prognostic value of R-pHSA in acute hepatitis B virus infection. High titers of R-pHSA were found in 12/12 patients with HBeAg positive acute hepatitis B (log2-Titer: 8.5 +/- 1.5). Titers for R-pHSA and HBsAg correlated closely. Furthermore, R-pHSA occurred (log2-titer: 6.5 +/- 1.5) in 10/10 patients with HBeAg positive chronic active hepatitis B (CAH-B). In the course of HBV infection, R-pHSA were eliminated earlier than HBsAg. 4/20 patients which were asymptomatic HBsAg carriers had high titers of R-pHSA in correlation to the histological findings of CAH-B. Asymptomatic HBsAg carriers which were R-pHSA negative had a normal liver histology. R-pHSA were found to be an early prognostic marker in acute hepatitis B infection.
D002353:Carrier State / Q000503:physiopathology; D006509:Hepatitis B / Q000503:physiopathology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006513:Hepatitis B e Antigens / Q000032:analysis; D006521:Hepatitis, Chronic / Q000503:physiopathology; D006801:Humans; D011379:Prognosis; D017457:Receptors, Albumin; D011946:Receptors, Antigen / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D014779:Virus Replication
D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D017457:Receptors, Albumin; D011946:Receptors, Antigen; D011956:Receptors, Cell Surface; C030500:hepatitis B surface antigen receptor
Nachweis und Bedeutung von HBsAg-assoziierten Rezeptoren für polymerisiertes Humanserumalbumin bei akuter Hepatitis-B-Virus-Infektion.