Dopaminergic influence on the effects of angiotensin II in behavioural reactions.
Using a neuropharmacological approach we studied the dopaminergic influence on the effects of angiotensin II (ATII) in some behavioural reactions. Haloperidol reduced the exploratory behaviour-increasing effect of ATII in the open field. Haloperidol also reduced the apomorphine stereotypy-increasing effect of ATII. Sulpiride tended to overcome the locomotor activity-decreasing effect of ATII. Seven resp. 21 days after withdrawal of pimozide (applied for 14 days) the convulsive-seizure thresholdincreasing effect of ATII was enhanced. Haloperidol impaired the retention-facilitating effect of ATII in rats performing a shuttle-box active avoidance task. The results suggest close interactions between central DA-ergic transmission and ATII in the realization of the ATII effects on behaviour.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D012640:Seizures / Q000139:chemically induced; D013239:Stereotyped Behavior / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D011954:Receptors, Dopamine; D000804:Angiotensin II; D004298:Dopamine