Biological activities of a human pluripotent hemopoietic colony stimulating factor on normal and leukemic cells.
We studied the biological effects of pluripoietin, a human pluripotent hemopoietic colony-stimulating factor (CSF) purified from the 5637 bladder carcinoma cell line. We found that this human CSF appears to be a unique hemopoietic growth factor, differing from interleukin 3 (IL-3) by virtue of its leukemia differentiating activity in mouse and man, and from mouse granulocyte CSF, which does have differentiation-inducing activity, but lacks pluripoietic activity. In addition, differences from IL-3 were observed in cross-species activity on normal and leukemic cells.
D000818:Animals; D002277:Carcinoma / Q000378:metabolism; D002455:Cell Division; D002460:Cell Line; D002470:Cell Survival; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology; D006098:Granulocytes / Q000378:metabolism; D006133:Growth Substances / Q000302:isolation & purification / Q000502:physiology*; D016298:Hematopoietic Cell Growth Factors; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008808:Mice, Inbred CBA; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000378:metabolism; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic / Q000032:analysis; D013045:Species Specificity; D013936:Thymidine / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000378:metabolism
D006133:Growth Substances; D016298:Hematopoietic Cell Growth Factors; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic; D009240:N-Formylmethionine Leucyl-Phenylalanine; D013936:Thymidine