title: Effect of 5,7-dihydroxytryptamine on the concentration of individual proteins in different areas of the rat brain.
abstract: Proteins which are apparently regulated in concentration in two different areas of the rat brain by the indole neurotransmitter serotonin were identified using two-dimensional gel electrophoresis combined with computerized scanning densitometry. Reduction in central serotonin levels produced a decrease in the concentration of 3 different proteins (2 in the parietal cortex, 1 in the hippocampus). Two proteins, both in the hippocampus, were elevated in concentration following serotonin depletion. These results demonstrate that there exist in the brain a limited number of proteins whose concentration is influenced by serotonin.
mesh_terms: D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D004102:Dihydroxytryptamines / Q000494:pharmacology*; D006624:Hippocampus / Q000032:analysis*; D007276:Injections, Intraventricular; D008297:Male; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000032:analysis*; D010296:Parietal Lobe / Q000032:analysis* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology; D009435:Synaptic Transmission
chemical_list: D004102:Dihydroxytryptamines; D009419:Nerve Tissue Proteins; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin