title: Malignant mesothelioma caused by childhood exposure to long-fiber low aspect ratio tremolite.
abstract: A 41-year-old man was found to have a malignant mesothelioma of the pleura. During childhood in Corsica, he had been exposed at home to chrysotile ore from the Canari mine. Analysis of lung mineral content revealed background levels of chrysotile but an elevated level of tremolite and actinolite asbestos. The latter had a geometric mean length of 3.7 microns, a value considerably longer than we have found for tremolite and actinolite from Quebec chrysotile miners but roughly the same as the mean length of amosite and crocidolite in workers with occupational amphibole exposure. No tremolite or actinolite fibers of length greater than 8 microns microns and width less than 0.25 micron were observed. The mean aspect ratio of the tremolite and actinolite fibers was 7, a value similar to that found in chrysotile miners with mesothelioma but considerably less than the mean aspect ratio of amosite and crocidolite from those with occupational exposure. These data suggest that long-fiber tremolite is a potential mesothelial carcinogen in humans, and that fiber length is more important than fiber aspect ratio in this regard.
mesh_terms: D000328:Adult; D017636:Asbestos, Amphibole; D001706:Biopsy; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000209:etiology* / Q000473:pathology; D008854:Microscopy, Electron; D010994:Pleura / Q000473:pathology; D010997:Pleural Neoplasms / Q000209:etiology* / Q000473:pathology; D012824:Silicic Acid / Q000009:adverse effects*; D012822:Silicon Dioxide / Q000009:adverse effects*
chemical_list: D017636:Asbestos, Amphibole; D012824:Silicic Acid; C005846:tremolite; D012822:Silicon Dioxide