Eicosapentaenoic acid metabolism in human and rabbit anterior uvea.
Eicosapentaenoic acid (EPA) metabolism into 3 series cyclooxygenase and 5 series lipoxygenase products was assessed in human and rabbit anterior uvea. Both tissues synthesized 3 series cyclooxygenase products such as delta17 6-keto-PGF1 (PGI3 metabolite), PGE3 alpha, PGE3, PGD3 and TxB3 (a stable product of TxA3) and lipoxygenase products 12-hydroxyeicosapentaenoic acid (HEPE), 5-HEPE and 5,12-diHEPE from 14C-EPA. EPA-derived cyclooxygenase product synthesis was considerably greater than the formation of lipoxygenase products from EPA in both tissues.
D000527:Alprostadil / Q000031:analogs & derivatives*; D000818:Animals; D002250:Carbon Radioisotopes; D002924:Ciliary Body / Q000378:metabolism*; D015118:Eicosapentaenoic Acid / Q000378:metabolism*; D006801:Humans; D007498:Iris / Q000378:metabolism*; D008084:Lipoxygenase / Q000502:physiology; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology; D011457:Prostaglandins D / Q000378:metabolism; D011458:Prostaglandins E / Q000378:metabolism; D011817:Rabbits
D002250:Carbon Radioisotopes; D011457:Prostaglandins D; D011458:Prostaglandins E; C027005:prostaglandin D3; C033246:prostaglandin E3; D015118:Eicosapentaenoic Acid; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D000527:Alprostadil