2,4-Dichlorophenoxyacetic acid (2,4-D) does not cause polyneuropathy in the rat.
2,4-Dichlorophenoxyacetic acid (2,4-D), a component of Agent Orange, was injected intraperitoneally into adult male Fisher rats for 3-12 weeks. During the period of study gait and toe-spreading reflexes remained normal and distal motor latencies, motor and mixed nerve conduction velocities and amplitudes remained similar (P greater than 0.05) in animals receiving 2,4-D or vehicle. This study suggests that 2,4-D is not toxic to peripheral nerves in the rat.
D015084:2,4-Dichlorophenoxyacetic Acid / Q000633:toxicity*; D000818:Animals; D008297:Male; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D051381:Rats; D011916:Rats, Inbred F344
D015084:2,4-Dichlorophenoxyacetic Acid