[Indices of alpha-interferon and of lymphocyte natural killer activity in genital herpes and the effect on them of specific vaccinal therapy and interferon therapy].
Fifty-six patients with recurrent genital herpes (RGH) and 53 normal subjects were examined. No interferon was found in the blood sera of the patients either in the period of the disease relapse or during remission. The leukocyte capacity to produce interferon in vitro (leukocyte interferon reaction, LIR) in the patients was found to be 4-5 times lower than in normal subjects. Study of the normal killer activity of lymphocytes in patients with RGH as compared with that in normal subjects revealed its decrease in 37.5% of the patients and only in 5.1% of normal subjects. Interferon therapy with purified human leukocyte interferon given to 36 patients with RGH resulted in clinical improvement in 88.9% of the patients that was accompanied by increasing normal killer activity of lymphocytes. Vaccine therapy given to 35 patients resulted in a stable clinical effect in 91.4% of the patients, however, without activation of LIR in them. It is concluded that the therapeutic effects of interferon therapy and vaccine therapy have different mechanisms.
D000328:Adult; D004341:Drug Evaluation; D006558:Herpes Genitalis / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007370:Interferon Type I / Q000097:blood* / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D018139:Simplexvirus / Q000276:immunology*; D014765:Viral Vaccines / Q000627:therapeutic use*
D007370:Interferon Type I; D014765:Viral Vaccines
Pokazateli al'fa-interferona i normal'noĭ killernoĭ aktivnosti limfotsitov pri genital'nom gerpese i vliianie na nikh spetsificheskoĭ vaktsinoterapii i interferonoterapii.