title: [Persistent (chronic active) Epstein-Barr virus infection and arthritis in childhood].
abstract: Between 1981 und 1983 some 1300 patients with the primary diagnosis of juvenile chronic arthritis were admitted. In 9 of them a persistent EBV-infection was simultaneously evident. The course of disease was primarily systemic with the characteristic criteria: high septic intermittent fever, rheumatic exanthema, hepatosplenomegaly and lymphadenopathy. It is still unclear whether a replication of virus in the synovia or a precipiation of immune complexes is involved. A common cause for the persistent EBV-infection and arthritis via an immune-suppressive agent is possible.
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000276:immunology; D001171:Arthritis, Juvenile / Q000175:diagnosis* / Q000276:immunology; D002648:Child; D005260:Female; D006566:Herpesviridae Infections / Q000175:diagnosis* / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D008297:Male
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral
vernacular_title: Persistierende (chronisch-aktive) Epstein-Barr-Virus-Infektion und Arthritis im Kindesalter.