Specific transfer factor protects mice against lethal challenge with herpes simplex virus.
Bovine transfer factor (TFd) specific to herpes simplex virus (HSV)1 or to HSV2 was prepared by immunizing calves with the corresponding virus. The TFd preparations were then injected into Swiss mice in an attempt to protect them against a subsequent lethal challenge with HSV1 or HSV2 virus. It was thus shown that injection of anti-HSV TFd protects the mice against the corresponding HSV virus, whereas the injection of a nonspecific TFd (anti-CMV) fails to protect against a challenge with HSV1. Furthermore, a dose-response effect was observed, since potent TFd preparations were ineffective when they were used at one-fifth of the original concentration. It seems, therefore, that animal models may be used to assay the potency of TFd preparations specific for herpes viruses.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000917:Antibody Formation; D004306:Dose-Response Relationship, Immunologic; D006561:Herpes Simplex / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D051379:Mice; D018139:Simplexvirus / Q000276:immunology*; D014165:Transfer Factor / Q000276:immunology / Q000494:pharmacology*
D000914:Antibodies, Viral; D014165:Transfer Factor