[The influence of carrageenan, colchicine, 2,4-dinitrophenol, ethanol, galactose, indomethacin and liquoid on hemolytic complement activity (CH50E)].
The influence of Liquoid (0.00005, 0.00001%), Carrageenan (0.001% up to 0.000001%), Colchicine (0.01% up to 0.0025%), Indomethacin (1 X 10(-4) up to 2.5 X 10(-5) mol/1), Ethanol (10% up to 1.25%), Galactose (1 X 10(-1) up to 1 X 10(-2) mol/l) and 2.4-Dinitrophenol (5 X 10(-4) up to 1 X 10(-5) mol/l) on the total hemolytic activity of complement was tested. By Liquoid, Carrageenan, Colchicine and Ethanol in all studied concentrations an remarkable inhibition of the CH50E could be estimated. Indomethacin up to an concentration of 3.75 X 10(-5) mol/l reduced the activity partially. In contrast, Galactose and 2.4-Dinitrophenol have not influenced the complement titers.
D019297:2,4-Dinitrophenol; D000818:Animals; D001557:Benzenesulfonates / Q000494:pharmacology*; D002351:Carrageenan / Q000494:pharmacology*; D003078:Colchicine / Q000494:pharmacology*; D003169:Complement Inactivator Proteins / Q000494:pharmacology; D003165:Complement System Proteins; D004140:Dinitrophenols / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D005690:Galactose / Q000494:pharmacology*; D006168:Guinea Pigs; D006461:Hemolysis / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology*; D011074:Polyanetholesulfonate / Q000494:pharmacology*
D001557:Benzenesulfonates; D003169:Complement Inactivator Proteins; D004140:Dinitrophenols; D000431:Ethanol; D011074:Polyanetholesulfonate; D002351:Carrageenan; D003165:Complement System Proteins; D019297:2,4-Dinitrophenol; D003078:Colchicine; D005690:Galactose; D007213:Indomethacin
Die Beeinflussung der hämolytischen Komplementaktivität (CH50E) durch Carrageenan, Colchicin, 2,4-Dinitrophenol, Ethanol, Galactose, Indomethacin und Liquoid.