Effects of an ACTH 4-9 analog on auditory evoked brainstem responses and middle latency responses.
Early and middle latency auditory evoked potentials (EAEPs and MAEPs) were recorded from thirteen male volunteers after oral administration of either 40 mg of an ACTH 4-9 analog (ORG 2766) or placebo. Main results indicate slightly longer latencies of the later components of the EAEPs after ACTH 4-9 analog. Effects of differences in treatment were clearest with very high stimulus rates. Therefore, these effects do not lend themselves for the explanation of ACTH 4-9 analog-induced changes in long latency auditory evoked potentials of cortical origin obtained with comparatively slow stimulus rates in earlier studies. In addition, the ACTH 4-9 analog inhibited a decrease in amplitudes of the Na component of the MAEP across the session. This latter result may be in line with dishabituating actions of the peptide.
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000328:Adult; D001143:Arousal / Q000187:drug effects; D001933:Brain Stem / Q000187:drug effects*; D004311:Double-Blind Method; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*
D010446:Peptide Fragments; C013765:Org 2766; D000324:Adrenocorticotropic Hormone