Influence of proopiomelanocortin-derived peptides on the sleep-waking cycle of the rat.
The effects of i.c.v. injections of different proopiomelanocortin-derived peptides were tested on the rat sleep-waking cycle: adrenocorticotropic hormone (ACTH) had no effect. In contrast, administration of two ACTH-derived peptides was followed by a selective and significant increase of each sleep state: desacetyl-alpha-melanocyte-stimulating hormone induced an increase of slow-wave sleep, while corticotropin-like intermediate lobe peptide was followed by an increase of paradoxical sleep. Both alpha-melanocyte-stimulating hormone in its acetylated form and alpha-endorphin were inactive.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001143:Arousal / Q000187:drug effects; D004723:Endorphins / Q000494:pharmacology; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D011333:Pro-Opiomelanocortin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D013997:Time Factors; D000521:alpha-MSH / Q000031:analogs & derivatives*
D004723:Endorphins; D010446:Peptide Fragments; D000521:alpha-MSH; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones