title: Cyclic nucleotide content of ciliary and dorsal root ganglia during embryonic development in the chick.
abstract: The concentration of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) was measured in developing chick ciliary (CG) and dorsal root ganglia (DRG) as a function of embryonic age from day 8 through day 18 using radioimmunoassays. The concentration of cAMP and cGMP increased in both ganglia from day 8 through day 14. cAMP levels were nearly two-fold higher in DRG than in CG. Normalization of the data for ciliary ganglia to the number of cells per ganglion and calculation of their molar concentrations indicates a 48% increase in cGMP and a 3.2-fold increase in cAMP during the developmental process of natural neuronal cell death.
mesh_terms: D000818:Animals; D002452:Cell Count; D002470:Cell Survival; D002642:Chick Embryo; D000242:Cyclic AMP / Q000032:analysis*; D006152:Cyclic GMP / Q000032:analysis*; D005726:Ganglia, Parasympathetic / Q000032:analysis* / Q000196:embryology; D005727:Ganglia, Spinal / Q000032:analysis* / Q000196:embryology; D009419:Nerve Tissue Proteins / Q000032:analysis
chemical_list: D009419:Nerve Tissue Proteins; D000242:Cyclic AMP; D006152:Cyclic GMP