title: Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization.
abstract: Human Tumor Necrosis Factor and Lymphotoxin are cytotoxic proteins which have similar biological activities and share 30 percent amino acid homology. The single copy genes which encode these proteins share several structural features: each gene is approximately three kilobase pairs in length and is interrupted by three introns. In addition, these genes are closely linked and have been mapped to human chromosome 6. However, only the last exons of both genes, which code for more than 80 percent of each secreted protein, are significantly homologous (56 percent).
mesh_terms: D000595:Amino Acid Sequence; D010582:Bacteriophage lambda / Q000235:genetics; D001483:Base Sequence; D002877:Chromosomes, Human; D003001:Cloning, Molecular; D004247:DNA / Q000378:metabolism; D004262:DNA Restriction Enzymes; D005796:Genes; D006023:Glycoproteins / Q000235:genetics*; D006131:Growth Inhibitors / Q000235:genetics*; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014409:Tumor Necrosis Factor-alpha
chemical_list: D006023:Glycoproteins; D006131:Growth Inhibitors; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha; D004247:DNA; D004262:DNA Restriction Enzymes