Activated alveolar macrophage and lymphocyte alveolitis in extrathoracic sarcoidosis without radiological mediastinopulmonary involvement.
Cellular characteristics of BAL were investigated in 18 patients with proved extrathoracic sarcoidosis (that is, sarcoidosis that affected the skin, eyes, parotid glands, stomach, nose, kidneys, or meninges) without clinical or radiological mediastinopulmonary involvement. Computed tomography of the thorax was performed on five patients: four patients were normal, and one had enlarged lymph nodes (these enlargements were not detectable on the patient's chest roentgenogram). The results of pulmonary function tests were normal in all patients. The total BAL cell count did not differ significantly between controls and patients. Abnormal percentages of alveolar lymphocytes (from 18 to 87%) were noted in 15 out of 18 patients. SACE levels were normal in 15 patients. No pulmonary gallium uptake was detected. The chemiluminescence of AM's, whether spontaneous or PMA induced, was increased in five out of seven patients. The percentages of T3+ lymphocytes in sarcoidosis patients did not significantly differ from those in controls. The T4+:T8+ ratio was normal in four patients and slightly increased in one. Follow-up of patients showed that alveolar lymphocytosis is as lasting as extrathoracic involvement. Our data demonstrate increased percentages of lymphocytes and activated AM's in the BAL of patients with extrathoracic sarcoidosis. This may be due to the initial involvement of the respiratory tract in extrathoracic sarcoidosis or to the diffusion of activated macrophages and lymphocytes from an extrathoracic site into the lung.
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000032:analysis; D001980:Bronchi; D003424:Crohn Disease / Q000276:immunology; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D008163:Luminescent Measurements; D008168:Lung / Q000000981:diagnostic imaging; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008262:Macrophage Activation / Q000187:drug effects; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011650:Pulmonary Alveoli / Q000276:immunology*; D011658:Pulmonary Fibrosis / Q000150:complications / Q000000981:diagnostic imaging / Q000276:immunology*; D011859:Radiography; D011877:Radionuclide Imaging; D012507:Sarcoidosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000276:immunology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D007507:Therapeutic Irrigation
D000911:Antibodies, Monoclonal; D005710:Gallium Radioisotopes; D007703:Peptidyl-Dipeptidase A; D013755:Tetradecanoylphorbol Acetate