title: Disruption of conditioned taste aversion by ECS: the role of lithium chloride.
abstract: Rats were taught a conditioned taste aversion (CTA) by pairing a 10% sucrose solution (CS) with lithium chloride (LiCl)-induced poisoning (UCS). The CS-UCS interval was 30 min. The LiCl dose (20 ml/kg) was either strong (0.15 M) or weaker (0.075 M). Electroconvulsive shock (ECS) (80 mA for 600 msec) was interpolated within the CS-UCS interval at either 15 or 30 min. ECS caused a significant disruption of CTA only when the aversion was established with the weaker dose of LiCl. There was also no indication that interference with CTA was dependent upon close temporal contiguity between the ECS and LiCl. In a second experiment a CTA was established with LiCl (0.15 M) which was heated to 45 degrees C. Under these conditions ECS produced a similar disruption of learning to that when the UCS was the weaker dose of LiCl (0.075 M). The results suggest that an apparent differential loss of learning within the CS-UCS interval described in a previous report was accidentally created when some groups of animals were poisoned with warm and others with cold LiCl.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002712:Chlorides / Q000633:toxicity*; D004597:Electroshock / Q000009:adverse effects*; D007859:Learning Disabilities / Q000209:etiology*; D008094:Lithium / Q000633:toxicity*; D018021:Lithium Chloride; D008297:Male; D051381:Rats; D013395:Sucrose; D013649:Taste / Q000187:drug effects*; D013696:Temperature
chemical_list: D002712:Chlorides; D013395:Sucrose; D008094:Lithium; D018021:Lithium Chloride