Application of radio-detoxified endotoxin as adjuvant for experimental foot-and-mouth disease vaccine.
The immunity enhancing adjuvant activity of radiodetoxified endotoxin (RD-LPS) on the potency of "C" type foot-and-mouth (FMD) vaccine was tested in different animal species. The suitable quantity of RD-LPS (20 micrograms per mouse) adjuvated a small than a high dose of FMD antigen. In cattle and sheep the adjuvant effect of oil + RD + LPS surpassed only slightly that of oil alone. The effect of RD-LPS in the pig was very pronounced when applied in small doses but further studies in larger animal populations have to confirm this result.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D005537:Aphthovirus / Q000276:immunology*; D002417:Cattle; D004731:Endotoxins / Q000494:pharmacology* / Q000528:radiation effects; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D012756:Sheep; D013552:Swine; D014765:Viral Vaccines / Q000276:immunology*
D000276:Adjuvants, Immunologic; D004731:Endotoxins; D014765:Viral Vaccines