Somata-selective lesions induced by cobaltous chloride: a parametric study.
Repeated injections of cobaltous chloride destroy neuronal somata while sparing fibers-of-passage. This effect is dose-dependent and excess cobalt destroys fibers-of-passage as well as somata. By manipulating the concentration and volume of cobaltous chloride injected into rat lateral geniculate nuclei, we defined a range of parameters producing highly selective destruction of somata for regions 1 mm in diameter or smaller.
D000818:Animals; D002415:Cats; D002470:Cell Survival / Q000187:drug effects; D003035:Cobalt / Q000633:toxicity*; D003864:Depression, Chemical; D005829:Geniculate Bodies / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D014795:Visual Pathways / Q000187:drug effects
D003035:Cobalt; C018021:cobaltous chloride