[Crystalline inclusions of the mouse thyroid. Effect of chronic treatment with lithium gluconate].
Intracytoplasmic crystalline bodies of various sizes are found in thyroid cells of 10-month-old mice and in younger animals under chronic lithium treatment. They are frequently surrounded by small microvesicles and dense bodies or enclosed in larger vesicles having a dense content. The crystalline skeleton is a network of protein fibers assembled in a characteristic axis with a periodicity of 8 nm. A deficiency of thyroid cell metabolism related to aging or lithium gluconate treatment would lead to an accumulation of substances of a crystalline pattern.
D000375:Aging; D000818:Animals; D003460:Crystallization; D005942:Gluconates / Q000494:pharmacology*; D002479:Inclusion Bodies / Q000187:drug effects / Q000648:ultrastructure*; D051379:Mice; D008854:Microscopy, Electron; D013961:Thyroid Gland / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D005942:Gluconates; D014284:Triiodothyronine; D013974:Thyroxine; C030691:gluconic acid
Les inclusions cristallines de la thyroïde de souris. Effet d'un traitement chronique au gluconate de lithium.