Hepatic effects of phenobarbitone in female mice fed sublethal levels of dietary cyanide.
Female albino mice were fed sublethal doses of KCN (approx. 10 micrograms/mouse/day) for 7 days, injected intraperitoneally with phenobarbitone (50 mg/kg body wt/day) in the subsequent 3 days, and sacrificed 24 hr after the last injection. Phenobarbitone sleeping time was increasingly shortened (16-27%) daily in cyanide-fed mice in comparison with cyanide-free controls. Both compounds administered singly or simultaneously increased the liver weight/body weight ratios by not more than 10%. Aniline hydroxylase, glucose-6-phosphatase, NADPH- and NADH-cytochrome c reductase activities were similarly increased. Aniline hydroxylase activity was most markedly increased (by a factor of 4). The toxicological implications of these results are discussed.
D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D003486:Cyanides / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D051379:Mice; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D011190:Potassium Cyanide / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity
D003486:Cyanides; D000815:Aniline Hydroxylase; D009251:NADPH-Ferrihemoprotein Reductase; D005952:Glucose-6-Phosphatase; D011190:Potassium Cyanide; D010634:Phenobarbital