Meningeal tumors of infancy and childhood.
Seventeen meningeal tumors were examined for pathology with electron microscopy and immunohistochemistry including glial fibrillary acidic protein (GFAP), S-100 protein, muramidase, and factor VIII. These tumors included seven meningiomas, one hemangiopericytoma, three meningeal sarcomas (1 pleomorphic-cell type and 2 myxofibrosarcomas), two fibrous histiocytomas, and four malignant melanomas. Two of seven children with meningioma had a poor outcome despite the benign histological features of the tumor. S-100 protein was present in the two tumors. All three children with meningeal sarcoma had a rapid downhill clinical course, although the myxofibrosarcoma initially had a relatively benign histological appearance. The two children with fibrous histiocytoma did well despite the aggressive histological features. Muramidase was a good marker of such tumors. Because of the morphological difficulties associated with childhood meningeal tumors, both electron microscopy and immunohistochemistry can be of diagnostic benefit.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006393:Hemangiopericytoma / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007223:Infant; D008297:Male; D008545:Melanoma / Q000473:pathology; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D008579:Meningioma / Q000473:pathology; D008854:Microscopy, Electron; D009418:S100 Proteins / Q000032:analysis; D012509:Sarcoma / Q000473:pathology
D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins