[Effect of serotonin on cholinergic septo-hippocampal reactions in the rabbit].
In noncurarized and unanaesthetized rabbits, the unit activity and field potentials evoked by testing stimulation of the medial septum were studied before, during (3-10 min), and in different periods (up. to 0.5 h) after microiontophoretic serotonin (5-OT) application or n. Raphe stimulation. In most of the cases, just during 5-OT application or n. Raphe stimulation, cholinergic septo-hippocampal responses decreased. Trace facilitatory effect of native and exogenously applied 5-OT on these responses was found. Increase of efficiency of cholinergic excitatory input was considered as a confirmation of the role of the serotonergic system in hippocampal long-term posttetanic potentiation after the stimulation of the medial septum. On the whole the data obtained indicate a complex modulatory 5-OT influence on the cholinergic septo-hippocampal responses.
D000818:Animals; D002799:Cholinergic Fibers / Q000187:drug effects; D004558:Electric Stimulation; D004594:Electrophysiology; D006624:Hippocampus / Q000187:drug effects*; D007478:Iontophoresis; D009434:Neural Pathways / Q000187:drug effects; D011817:Rabbits; D011903:Raphe Nuclei / Q000187:drug effects*; D012686:Septal Nuclei / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects
D012701:Serotonin
Vliianie serotonina na kholinergicheskie septo-gippokampal'nye reaktsii u krolikov.