Relapsing central and peripheral demyelinating diseases. Unusual pathologic features.
We treated a patient who had a demyelinating peripheral neuropathy and a central nervous system inflammatory demyelinating disease. The unusual pathologic feature of dense infiltrates of atypical macrophages was observed in many areas of the brain; otherwise the process had several features in common with either multiple sclerosis or chronic relapsing experimental allergic encephalomyelitis. The illness followed "swine-flu" inoculation; exacerbation followed pneumococcal vaccination.
D001428:Bacterial Vaccines / Q000009:adverse effects; D001921:Brain / Q000473:pathology; D003711:Demyelinating Diseases / Q000209:etiology / Q000473:pathology*; D004660:Encephalitis / Q000209:etiology / Q000473:pathology; D006801:Humans; D009980:Influenza A virus; D007252:Influenza Vaccines / Q000009:adverse effects; D007943:Leukemia, Hairy Cell / Q000150:complications; D008264:Macrophages / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000473:pathology*; D022242:Pneumococcal Vaccines; D012008:Recurrence
D001428:Bacterial Vaccines; D007252:Influenza Vaccines; D022242:Pneumococcal Vaccines