[Hypnogenic effects of des-acetyl-alpha-MSH and CLIP (ACTH 18-39) in the rat].
In the rat, the intraventricular administration of ACTH (adrenocorticotropic hormone) has no effect upon the sleep-waking cycle. However, administration of two ACTH-derived peptides is followed by a selective and significant increase of each sleep state: Des-alpha-MSH (Des-acetyl-alpha-melanocyte stimulating hormone) administration induces an increase of slow wave sleep, while CLIP (corticotropin-like intermediate lobe peptide) is followed by an increase of paradoxical sleep.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D053497:Corticotropin-Like Intermediate Lobe Peptide; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D000521:alpha-MSH / Q000031:analogs & derivatives*
D006993:Hypnotics and Sedatives; D010446:Peptide Fragments; D053497:Corticotropin-Like Intermediate Lobe Peptide; D000521:alpha-MSH; D000324:Adrenocorticotropic Hormone
Effets hypnogènes de la des-acetyl-alpha-MSH et du CLIP (ACTH 18-39) chez le rat.