Spleen specific expression of an MMTV related transcript associated with the Mtv-6 locus in BALB/c mice.
We have detected an MMTV related transcript which is expressed in a spleen specific manner in BALB/cHeA mice. Using a recombinant inbred series between BALB/cHeA and STS/A mice (C X S RI series) we have identified RNA associated with the Mtv-3 locus of the STS/A strain. This transcript initiates at the same site in the MMTV LTR as already reported for Mtv-2 and Mtv-8. The novel spleen specific MMTV transcript in the BALB/cHeA strain has a different structure as compared to the transcripts associated with the Mtv-2, Mtv-3, or Mtv-8 loci. We have tentatively identified the Mtv-6 locus as the source of these unique transcripts.
D000818:Animals; D002472:Cell Transformation, Viral; D005786:Gene Expression Regulation; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics*; D013154:Spleen / Q000502:physiology*; D014158:Transcription, Genetic
D012333:RNA, Messenger; D012367:RNA, Viral