Protective effect of monoclonal antibodies on lethal mouse hepatitis virus infection in mice.
Neutralizing and nonneutralizing monoclonal antibodies to the peplomer glycoprotein and nucleocapsid protein of a mouse hepatitis virus (MHV), MHV-NuU, protected mice against lethal MHV-2 challenge. Histopathologically, livers of mice receiving protective antibodies showed some focal necrotic lesions with remarkable cellular infiltration instead of fulminant hepatitis caused by MHV-2.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000914:Antibodies, Viral / Q000627:therapeutic use*; D005260:Female; D006524:Hepatitis, Viral, Animal / Q000473:pathology / Q000517:prevention & control*; D007116:Immunization, Passive; D051379:Mice; D008807:Mice, Inbred BALB C; D006517:Murine hepatitis virus / Q000254:growth & development / Q000276:immunology*; D009500:Neutralization Tests
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral