[The effects of neocarzinostatin on superoxide production by monocyte-derived macrophages].
Monocyte-derived macrophages (M phi) from cancer patients injected with low doses of Neocarzinostatin (NCS, 500 units/day, three times a week) 12 times produced significantly more superoxide (O2-) than controls. Lymphocyte functions, such as PHA response, surface marker and serum IAP, before and after NCS injections were the same. M phi from normal persons cultured with NCS (0.4 microgram/ml) for three days produced more O2- than controls, but those cultured with rINF gamma did not. These results suggest that the increased O2- production of M phi from patients taking low doses of NCS may be due to the direct action of NCS on the M phi.
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000276:immunology / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000145:classification; D008264:Macrophages / Q000378:metabolism*; D009000:Monocytes; D009363:Neoplasm Proteins / Q000032:analysis; D013274:Stomach Neoplasms / Q000276:immunology / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*; D009353:Zinostatin / Q000494:pharmacology*
D000903:Antibiotics, Antineoplastic; D007370:Interferon Type I; D009363:Neoplasm Proteins; C030193:immunosuppressive acidic protein; D013481:Superoxides; D009353:Zinostatin