Synergistic effect of human leukocyte interferon and nonoxynol 9 against herpes simplex virus type 2.
The nonionic surfactant nonoxynol 9 (NP9), in combination with human alpha interferon, synergistically reduced the titer of herpes simplex virus type 2 (HSV-2) in vitro. The degree of synergy was highest at an interferon concentration of 10(3) IU/ml and an NP9 dilution of 1:1,500. We postulate that NP9 inactivates extracellular HSV-2, whereas interferon inhibits HSV-2 replication at the intracellular level.
D000287:Administration, Topical; D002478:Cells, Cultured; D003902:Detergents / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006561:Herpes Simplex / Q000188:drug therapy*; D007370:Interferon Type I / Q000008:administration & dosage*; D017137:Nonoxynol; D011092:Polyethylene Glycols / Q000008:administration & dosage*
D003902:Detergents; D007370:Interferon Type I; D017137:Nonoxynol; D011092:Polyethylene Glycols