Two brain cholecystokinin receptors: implications for behavioral actions.
The distribution and relative specificity of cholecystokinin (CCK) receptors in the rat brain was mapped by in vitro autoradiography with [125I]CCK-33. We identified two distinct binding patterns, suggesting two CCK receptor types. The first is widespread and relatively non-specific. The second, localized to a few subcortical nuclei, has the specificity demonstrated for pancreatic CCK receptors. Localization of this receptor type to the area postrema provides a possible entry site into brain for circulating CCK that would distinguish between CCK and gastrin and could mediate some of CCK's behavioral effects.
D000818:Animals; D001345:Autoradiography; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000145:classification / Q000378:metabolism* / Q000502:physiology; D011949:Receptors, Cholecystokinin; D014018:Tissue Distribution
D011956:Receptors, Cell Surface; D011949:Receptors, Cholecystokinin