title: Bone formation within porous hydroxylapatite implants in human periodontal defects.
abstract: Tissue samples from three subjects who had periodontal defects treated with a porous hydroxylapatite implant were investigated using light microscopy and scanning electron microscopy. The 3-month specimen showed connective tissue infiltration through the pores and a narrow zone of bone formation present along the walls of the pores. At 4 months, continued evidence of bone deposition was present with osteocytes, osteoblasts and organization of collagen fibers apparent throughout the implant. The 6-month implant had further evidence of continued bone formation with lamellar bone being the major component within the pores.
mesh_terms: D000539:Alveolar Process / Q000033:anatomy & histology* / Q000502:physiology / Q000648:ultrastructure; D003094:Collagen; D003238:Connective Tissue / Q000033:anatomy & histology / Q000648:ultrastructure; D017886:Durapatite; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D006882:Hydroxyapatites; D010006:Osteoblasts / Q000648:ultrastructure; D010012:Osteogenesis; D010510:Periodontal Diseases / Q000601:surgery*; D019736:Prostheses and Implants; D013499:Surface Properties
chemical_list: D006882:Hydroxyapatites; D003094:Collagen; D017886:Durapatite