Anti-Epstein-Barr virus memory T-cell response in Chediak-Higashi syndrome patients.
Memory cytotoxic T-cell responses to Epstein-Barr virus transformed B cells were studied in two EBV seropositive Chediak-Higashi syndrome patients who were manifesting the terminal lymphoproliferative stage of the syndrome. The number of cells required for 50% regression of EBV-infected autologous lymphoblastoid cell lines was similar to that in the parents and healthy subjects. This indicates adequate memory cytotoxic T-cell control of EBV-infected B lymphocytes. Defective mechanisms other than those mediated by circulating cytotoxic cells, might be responsible for the chronic active EBV infection observed in these patients.
D001402:B-Lymphocytes / Q000276:immunology; D002472:Cell Transformation, Viral; D002609:Chediak-Higashi Syndrome / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004854:Herpesvirus 4, Human; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D008232:Lymphoproliferative Disorders / Q000276:immunology; D010290:Parents; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M