Intracellular recordings from rat nucleus accumbens neurons in vitro.
Intracellular recordings were obtained from rat nucleus accumbens (NAC) neurons in brain slice preparations. Local stimulations evoked depolarizing postsynaptic potential (DPSP). Injections of low intensity depolarizing currents decreased the amplitude of the DPSP and reversed a later portion of the DPSP into a hyperpolarizing potential. Superfusion of pentobarbital facilitated the reversal of this later portion of DPSP and bicuculline abolished this polarity reversal. These data suggested that the DPSP evoked by local stimulation consisted of a combination of an excitatory and an inhibitory postsynaptic potential, and that the latter was probably mediated by gamma-aminobutyric acid.
D000818:Animals; D005071:Evoked Potentials; D066298:In Vitro Techniques; D008297:Male; D009433:Neural Inhibition; D009714:Nucleus Accumbens / Q000502:physiology*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D012686:Septal Nuclei / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D005680:gamma-Aminobutyric Acid; D010634:Phenobarbital