Effect of recombinant DNA-derived bovine and human interferons on replication of bovine herpesvirus-1, parainfluenza-3, and respiratory syncytial viruses.
Antiviral effects of recombinant DNA-derived bovine (Bo) and human (Hu) interferons (IFN) on the replication of bovine herpesvirus-1, parainfluenza-3, and respiratory syncytial viruses were studied. Bovine monolayer cultures were treated with recombinant DNA-produced Bo IFN-alpha 1, Bo IFN-beta 2, Hu IFN-alpha A, or Hu IFN-alpha A/D and then challenge exposed with bovine herpesvirus-1, bovine parainfluenza-3 virus, bovine respiratory syncytial virus, or vesicular stomatitis virus. Treatment with each IFN reduced the viral yield for each of these viruses, compared with that of control cultures.
D000818:Animals; D002417:Cattle; D002460:Cell Line; D004261:DNA Replication / Q000187:drug effects*; D004274:DNA, Recombinant / Q000378:metabolism; D006564:Herpesviridae / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D007370:Interferon Type I / Q000235:genetics / Q000494:pharmacology*; D007668:Kidney; D010224:Parainfluenza Virus 3, Human / Q000187:drug effects / Q000235:genetics*; D011994:Recombinant Proteins / Q000494:pharmacology*; D012136:Respiratory Syncytial Viruses / Q000187:drug effects / Q000235:genetics*; D018108:Respirovirus / Q000235:genetics*; D013045:Species Specificity; D014779:Virus Replication / Q000187:drug effects
D004274:DNA, Recombinant; D007370:Interferon Type I; D011994:Recombinant Proteins