title: Changes in the levels of coenzyme Q homologues, alpha-tocopherol and malondialdehyde in human tissue during the course of circulatory shock.
abstract: Following our previous findings on mitochondrial oxidative damage during the course of circulatory shock in human muscular tissue, in the present work we examined the pathogenic connections between the electron-transport-chain enzymic activity and the ubiquinone metabolism. The effects of the oxidative damage on the alpha-tocopherol content and malondialdehyde (MDA) levels were also studied. The results reveal an involvement of cytochrome oxidase and coenzyme Q10 in the oxidative damage due to shock; alpha-tocopherol seems to show a particularly increased antioxidant activity contemporary with the marked increase in MDA levels. These findings suggest that the significant fall in the mitochondrial oxidative capacity could generate an oxygen free-radical production with subsequent peroxidative damage of the mitochondrial inner-membrane bilayer.
mesh_terms: D001794:Blood Pressure; D002302:Cardiac Output; D003576:Electron Transport Complex IV / Q000378:metabolism; D006339:Heart Rate; D006801:Humans; D008314:Malonates / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism*; D012769:Shock / Q000378:metabolism / Q000503:physiopathology*; D012770:Shock, Cardiogenic / Q000378:metabolism / Q000503:physiopathology; D014451:Ubiquinone / Q000378:metabolism*; D014655:Vascular Resistance; D014810:Vitamin E / Q000378:metabolism*
chemical_list: D008314:Malonates; D014451:Ubiquinone; D014810:Vitamin E; D008315:Malondialdehyde; D003576:Electron Transport Complex IV