title: [Antiviral chemotherapy].
abstract: After a discussion of the principles of antiviral chemotherapy, treatment and chemoprophylaxis of the following virus infections are reviewed in detail: the various manifestations of herpes simplex virus infections, varicella-zoster, cytomegalovirus infections, Epstein-Barr virus infections, laryngeal papillomas, and influenza A. Special reference is made to the treatment of immunocompromized patients. Acycloguanosine (acyclovir) has been found particularly useful in the treatment of herpes simplex virus and varicella zoster virus infections in immunocompromized patients and for herpesencephalitis. Varicella-zoster can also be treated effectively with bromovinyldeoxyuridine (BVDU). Toxicity of the currently used antiviral drugs is discussed as well as the problem of drug resistance.
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives / Q000627:therapeutic use; D002644:Chickenpox / Q000188:drug therapy; D002648:Child; D002986:Clinical Trials as Topic; D003586:Cytomegalovirus Infections / Q000188:drug therapy; D004311:Double-Blind Method; D004660:Encephalitis / Q000188:drug therapy; D005260:Female; D006558:Herpes Genitalis / Q000188:drug therapy; D006561:Herpes Simplex / Q000188:drug therapy; D006562:Herpes Zoster / Q000188:drug therapy; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy; D007231:Infant, Newborn; D006559:Pemphigoid Gestationis / Q000188:drug therapy; D011247:Pregnancy; D014740:Vidarabine / Q000627:therapeutic use; D014777:Virus Diseases / Q000188:drug therapy*
chemical_list: D000998:Antiviral Agents; C020235:brivudine; D014740:Vidarabine; D001973:Bromodeoxyuridine; D000212:Acyclovir
vernacular_title: Antivirale Chemotherapie.