Inactivation and partition of human T-cell lymphotrophic virus, type III, during ethanol fractionation of plasma.
Because of concern about the safety of immune globulins prepared for injection, we studied the effects of ethanol fractionation of human plasma on human lymphotropic virus, type III, (HTLV-III) by spiking the products of various fractionation steps with HTLV-III. Tests of inactivation and removal indicated that the ratio of residual live virus in plasma fractions/live virus in starting plasma was about 1 X 10(-15) for precipitate II from which immune globulin for injection is manufactured. The results are reassuring regarding the potential safety of immune globulin.
D017977:Deltaretrovirus / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D007136:Immunoglobulins / Q000302:isolation & purification*; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects
D007136:Immunoglobulins; D000431:Ethanol