title: [Cyclic nucleotides in multiple sclerosis].
abstract: The authors studied concentrations of cyclic nucleotides (cAMP and cGMP), as well as their ratio in the blood plasma and cerebrospinal fluid (CSF) of 83 patients with disseminated sclerosis of different forms and variants. An elevation in cAMP concentrations in the plasma and CSF detected in all the patients was more expressed in cases of a long standing and disseminated process. Blood levels of cAMP showed greater variability in the period of exacerbation versus remission of the disease.
mesh_terms: D000328:Adult; D000242:Cyclic AMP / Q000097:blood / Q000134:cerebrospinal fluid; D006152:Cyclic GMP / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000378:metabolism*; D009712:Nucleotides, Cyclic / Q000032:analysis*
chemical_list: D009712:Nucleotides, Cyclic; D000242:Cyclic AMP; D006152:Cyclic GMP
vernacular_title: Tsiklicheskie nukleotidy pri rasseiannom skleroze.