Marek's disease--a model for herpesvirus oncology.
The article will review the salient features of pathogenesis of Marek's disease in terms of sequential events which occur from the time of virus entry to the development of frank lymphomas. A hypothesis will be presented which will offer a credible explanation for this specific sequence of changes. Then, various factors which influence the incidence of neoplasms will be identified and the possible mechanisms by which they are influential will be discussed. These include the variable oncogenic properties of different virus strains, the influence of host genotype, and immune responses.
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002472:Cell Transformation, Viral; D003588:Cytopathogenic Effect, Viral; D004195:Disease Models, Animal; D008381:Herpesvirus 2, Gallid / Q000276:immunology / Q000472:pathogenicity*; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007108:Immune Tolerance; D007113:Immunity, Innate; D008214:Lymphocytes / Q000276:immunology; D008223:Lymphoma / Q000382:microbiology; D008380:Marek Disease / Q000503:physiopathology*; D013997:Time Factors; D014779:Virus Replication
D000949:Histocompatibility Antigens Class II