Leukotriene effects upon the transgastric potential difference and pepsin secretion.
The effects of leukotrienes on gastric mucosal function in vivo, and on acid and pepsin secretion in vitro were investigated. In cats, treatment with leukotrienes C4 (LTC4), D4 (LTD4), and E4 (LTE4) caused significant decreases in the transgastric electrical potential difference (P.D.) and significant increases in pepsin secretion, which returned toward control levels over 30-90 min. No detectable changes were observed in either acid concentration or gastric secretion volume over the entire 210 min experimental period. Leukotriene B4 (LTB4) had no effect upon any of these parameters. Treatment with LTD4 in isolated rabbit gastric glands resulted in significant increases in pepsin secretion, with no changes observed in aminopyrine accumulation (acid secretion). These results indicate that exogeneous LTC4, LTD4 and LTE4 can affect certain gastric mucosal functions.
D000818:Animals; D000983:Antipyrine / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D003994:Bucladesine / Q000494:pharmacology; D002415:Cats; D005088:Exocrine Glands / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007263:Infusions, Parenteral; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D010434:Pepsin A / Q000378:metabolism*; D013189:SRS-A / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects / Q000502:physiology*
D013189:SRS-A; D003994:Bucladesine; D010434:Pepsin A; D000983:Antipyrine