title: [Retroviruses and the immune system].
abstract: Three examples are presented to illustrate the importance of retroviruses and associated oncogenes in neoplasms of the immune system. In adult T-cell leukemia/lymphoma the HTLV I-provirus is often integrated in the human genome on chromosome 8 adjacent to the c-myc protooncogene. Cytogenetic studies of Burkitt's lymphoma (translocation of a chromosome 8 fragment) and a case of mycosis fungoides (trisomy of chromosome 8) indicate that the same oncogene may possibly be activated not only by retroviruses, but also by chromosomal aberrations.
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D002051:Burkitt Lymphoma / Q000276:immunology; D017977:Deltaretrovirus / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000276:immunology; D009182:Mycosis Fungoides / Q000276:immunology; D011519:Proto-Oncogenes; D012190:Retroviridae / Q000276:immunology; D012192:Retroviridae Infections / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology
vernacular_title: Retroviren und Immunsystem.