Morphine and methadone impact on human phagocytic physiology.
Human subjects submitted to treatment with morphine show a severe depression of phagocytosis, killing properties and superoxide production both of their polymorphonuclear leukocytes and monocytes. Polymorphonuclear leukocyte adherence, chemotaxis, random migration, myeloperoxidase content, lysozyme content and lymphocyte Rosette E formation were poorly influenced. Methadone-treated subjects show a similar effect at phagocytic level but far less evident. These results confirm those previously found in animals and reinforce the evidence of a depressive role of morphine on phagocytic physiology.
D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents; D008691:Methadone / Q000009:adverse effects*; D009000:Monocytes / Q000187:drug effects / Q000502:physiology; D009021:Morphine Dependence / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology*; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D010586:Phagocytes / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects; D013481:Superoxides / Q000097:blood
D007166:Immunosuppressive Agents; D013481:Superoxides; D008691:Methadone