Effects of a fish oil supplement on platelet function, haemostatic variables and albuminuria in insulin-dependent diabetics.
A randomised trial of the effects of 15 gm per day of a fish oil supplement (MaxEPA) on blood lipids, haemostatic variables (including platelet function) and albuminuria was undertaken in 41 insulin dependent diabetics. Compared with the control group there was a significant reduction in thromboxane production by platelets stimulated by collagen in vitro in the group who took the fish oil supplement. The extent of platelet aggregation was not altered but the lag phase before aggregation was prolonged. There were also statistically significant increases in plasma LDL cholesterol, fibrinogen and clotting factor X in the group who took the fish oil supplement. No other significant differences were noted.
D000284:Administration, Oral; D000328:Adult; D000419:Albuminuria / Q000178:diet therapy*; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000178:diet therapy; D003927:Diet, Diabetic; D004281:Docosahexaenoic Acids; D004338:Drug Combinations; D015118:Eicosapentaenoic Acid / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage* / Q000494:pharmacology; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D010979:Platelet Function Tests; D013928:Thromboxane A2 / Q000378:metabolism
D004338:Drug Combinations; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; C045153:Maxepa; D004281:Docosahexaenoic Acids; D013928:Thromboxane A2; D015118:Eicosapentaenoic Acid