Determination of the parental origin of sex-chromosome monosomy using restriction fragment length polymorphisms.
The parental origin of the single X chromosome in sex-chromosome monosomy was evaluated by comparing restriction fragment length polymorphisms (RFLPs) of 10 spontaneous aborted 45,X conceptions with those of their parents. Seven X-linked marker loci were used, and we were able to specify the origin of the X in nine cases, with six being maternally and three paternally derived. These results demonstrate the efficiency of the technique and show that the single X chromosome in 45,X spontaneous abortions can be derived from either parent.
D000022:Abortion, Spontaneous / Q000235:genetics; D002872:Chromosome Deletion; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D009006:Monosomy; D009693:Nucleic Acid Hybridization; D010290:Parents; D011110:Polymorphism, Genetic; D011247:Pregnancy; D014960:X Chromosome
D005819:Genetic Markers; D004247:DNA; D004262:DNA Restriction Enzymes