Influence of chemotherapy on superoxide anion-generating activity of polymorphonuclear leukocytes in patients with lung cancer.
The superoxide anion (O2-) generating activity of polymorphonuclear leukocytes (PMN) in peripheral venous blood obtained from 15 patients with lung cancer was measured weekly after drug treatment. The amount of O2- generated by the cells before chemotherapy was 5.74 +/- 0.42 nmol/minute/10(6) cells (mean +/- SE). The value decreased gradually and reached a nadir of 1.98 +/- 0.24 at 2 weeks after chemotherapy, at which time PMN count also reached a nadir of 1359 +/- 251/microliters (mean +/- SE). The decreased O2- generating activity of the PMN recovered gradually thereafter and reached the level seen before the chemotherapy at 4 weeks. Expression of Fc receptors on the plasma membrane in PMN was measured after chemotherapy by the binding of iodine 125 (125I)-immune complexes to the cells. Almost 40% decrease of the binding was observed in the cells obtained at 2 weeks after chemotherapy, compared with that in the cells before chemotherapy. These results indicate that PMN present in peripheral blood at 2 weeks after chemotherapy are not fully matured, in terms of O2- generating activity and the expression of Fc receptors.
D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism / Q000532:radiotherapy; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000378:metabolism / Q000532:radiotherapy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000378:metabolism / Q000532:radiotherapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D011961:Receptors, Fc / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*; D013997:Time Factors
D011961:Receptors, Fc; D013481:Superoxides