title: Ion transport regulation by prostaglandins in mouse macrophages.
abstract: Although the prostaglandins PGE1, PGE2 and PGF2 alpha had no effect on ion transport in isolated human erythrocytes, they modulated ion transport in isolated mouse macrophages, apparently through the mediation of cAMP, by inhibiting the NA+, K+ cotransport system, stimulating the Na+, K+ pump, and stimulating the Na+: Ca++ exchange mechanism.
mesh_terms: D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D000242:Cyclic AMP / Q000502:physiology; D015237:Dinoprost; D015232:Dinoprostone; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007700:Kinetics; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D011188:Potassium / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism*; D028021:Sodium-Potassium-Chloride Symporters
chemical_list: D001095:Arachidonic Acids; D002352:Carrier Proteins; D011458:Prostaglandins E; D011460:Prostaglandins F; D028021:Sodium-Potassium-Chloride Symporters; D016718:Arachidonic Acid; D012964:Sodium; D015237:Dinoprost; D000242:Cyclic AMP; D000527:Alprostadil; D015232:Dinoprostone; D011188:Potassium; D002118:Calcium; D007213:Indomethacin