title: Enhanced phosphatidylinositol kinase activity is associated with early stages of hepatocarcinogenesis and hepatocellular carcinoma.
abstract: Liver phosphatidylinositol (PI) kinase activity was determined in rats exposed to two different hepatocarcinogenic regimens. In contrast to partial treatment regimens the complete Solt and Farber hepatocarcinogenic regimen caused a significant increase in liver PI kinase activity at day 11 after partial hepatectomy. PI kinase activity in hepatocarcinomas removed 15 1/2 months after initiation of the complete Solt and Farber regimen was 2-fold higher than normal liver tissue surrounding the tumors. Compared to a choline supplemented diet a hepatocarcinogenic regimen consisting of a diet deficient in choline and methionine significantly increased liver PI kinase activity after 26 days. These data demonstrate that liver PI kinase activity is selectively elevated during hepatocarcinogenesis.
mesh_terms: D019870:1-Phosphatidylinositol 4-Kinase; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000201:enzymology*; D002796:Choline Deficiency / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008113:Liver Neoplasms; D008114:Liver Neoplasms, Experimental / Q000201:enzymology*; D008297:Male; D008715:Methionine / Q000172:deficiency; D010770:Phosphotransferases / Q000032:analysis*; D011230:Precancerous Conditions / Q000201:enzymology; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D008715:Methionine; D010770:Phosphotransferases; D019870:1-Phosphatidylinositol 4-Kinase