A new member of the plasma protease inhibitor gene family.
A 2.1-kb cDNA clone representing a new member of the protease inhibitor family was isolated from a human liver cDNA library. The inhibitor, named human Leuserpin 2 (hLS2), comprises 480 amino acids and contains a leucine residue at its putative reactive center. HLS2 is about 25-28% homologous to three human members of the plasma protease inhibitor family: antithrombin III, alpha 1-antitrypsin and alpha 1-antichymotrypsin. A comparison with published partial amino acid sequences shows that hLS2 is closely related to the thrombin inhibitor heparin cofactor II.
D000595:Amino Acid Sequence; D001483:Base Sequence; D001798:Blood Proteins; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis; D004262:DNA Restriction Enzymes; D005796:Genes; D015844:Heparin Cofactor II; D006801:Humans; D008099:Liver / Q000378:metabolism; D009693:Nucleic Acid Hybridization; D010047:Ovalbumin / Q000235:genetics; D010957:Plasmids; D011480:Protease Inhibitors / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D000515:alpha 1-Antitrypsin / Q000235:genetics
D001798:Blood Proteins; D011480:Protease Inhibitors; D011506:Proteins; C047932:SERPIND1 protein, human; D000515:alpha 1-Antitrypsin; D015844:Heparin Cofactor II; D010047:Ovalbumin; D004247:DNA; D004262:DNA Restriction Enzymes