[Prognostic significance of immunoreactivity of regional lymph nodes in colorectal cancer--an analysis of 2,502 cases. National Cooperative Group on Pathology and Prognosis of Colorectal Cancer].
This paper presents an analysis of the relation between immunoreactivity of the regional lymph node and survival rate. 2,502 cases of colorectal cancer collected from 13 areas in China were studied. The immunomorphology of the regional lymph node in this study was shown by sinus histiocytosis (SH), paracortical hyperplasia (PH) and germinal hyperplasia (GH). Each of these reactions was divided into 4 grades (-, +, ++, +++). The results show: A significant correlation exists between the extent of immunoreaction and prognosis. The 5 year survival rates of patients with SH (++, +++), PH (++, +++), GH (++, +++) are 59.0%, 58.1% and 62.1% respectively, much higher than those in the negative groups (P less than 0.001). The effect of these three immunoreactive features on prognosis is diverse. The 5 year survival rate of cases with simple GH (++, +++) is 62.9%, statistically higher than those of cases with simple PH (++, +++) or SH (++, +++). It seems that the B-cell may play a very important role in the host defence mechanism. It was found that SH (++, +++), PH (++, +++) and GH (++, +++) occurred more frequently in Dukes' A stage than those in Dukes' C stage. The same phenomenon is also identified in comparing the well-differentiated with the poorly-differentiated cases.
D002288:Adenocarcinoma, Mucinous / Q000276:immunology; D000231:Adenocarcinoma, Papillary / Q000276:immunology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000276:immunology; D003110:Colonic Neoplasms / Q000276:immunology*; D006801:Humans; D006965:Hyperplasia; D008198:Lymph Nodes / Q000276:immunology* / Q000473:pathology; D011379:Prognosis; D012004:Rectal Neoplasms / Q000276:immunology*