Effect of trimetazidine on membrane damage induced by oxygen free radicals in human red cells.
The effect of trimetazidine, 1-(2, 3, 4 trimethoxybenzyl)piperazine di-hydrochloride, on membrane damage induced by oxygen free radicals in red cells was studied in seven healthy volunteers after oral administration. Red cells collected prior to and after a 7 day treatment period with trimetazidine were incubated in the presence of phenazine methosulphate (an intracellular oxygen free radical generator) and diethyldithiocarbamate (a Cu-Zn superoxide dismutase inhibitor). The loss of intracellular K+ induced by oxygen free radicals and the membrane content of peroxidated lipids were significantly reduced in red cells collected after the period of treatment. These results indicate a potent antioxidant activity of trimetazidine which could explain its cardioprotective role during ischaemic and reperfusion phases in which oxygen free radicals are generated and probably implicated in the genesis of cardiac cell injury.
D000328:Adult; D002463:Cell Membrane Permeability / Q000187:drug effects; D004050:Ditiocarb / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects*; D005260:Female; D005609:Free Radicals; D006801:Humans; D008297:Male; D008315:Malondialdehyde; D008773:Methylphenazonium Methosulfate / Q000494:pharmacology; D010100:Oxygen / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011188:Potassium / Q000097:blood; D014292:Trimetazidine / Q000494:pharmacology*
D005609:Free Radicals; D010879:Piperazines; D008773:Methylphenazonium Methosulfate; D008315:Malondialdehyde; D004050:Ditiocarb; D014292:Trimetazidine; D011188:Potassium; D010100:Oxygen