Character of (D-Phe-7) ACTH4-10-induced excessive grooming.
Rats receiving (D-Phe-7) ACTH4-10 exhibited excessive grooming during the first half of the hour-long observation period. This resulted in total grooming scores of about one-half of those produced by the longer ACTH fragments, ACTH1-24 or ACTH1-16 NH2. The excessive grooming induced by (D-Phe-7) ACTH4-10 was due to an enhancement of duration of grooming bouts and not to an increase in the frequency of occurrence. Furthermore, the neuropeptide-induced excessive grooming was eliminated by prior treatment with naloxone.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology* / Q000031:analogs & derivatives; D000818:Animals; D005260:Female; D006120:Grooming / Q000187:drug effects*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010446:Peptide Fragments; C034159:ACTH (4-10), Phe(7)-; D000324:Adrenocorticotropic Hormone