title: Cachectin and tumour necrosis factor as two sides of the same biological coin.
abstract: In response to invasive stimuli macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents; D005075:Biological Evolution; D002100:Cachexia / Q000503:physiopathology*; D004731:Endotoxins / Q000494:pharmacology; D005796:Genes; D006023:Glycoproteins / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D008071:Lipoprotein Lipase / Q000037:antagonists & inhibitors*; D008233:Lymphotoxin-alpha / Q000235:genetics; D011506:Proteins / Q000502:physiology* / Q000627:therapeutic use; D011956:Receptors, Cell Surface / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor; D012689:Sequence Homology, Nucleic Acid; D014409:Tumor Necrosis Factor-alpha
chemical_list: D000970:Antineoplastic Agents; D004731:Endotoxins; D006023:Glycoproteins; D008233:Lymphotoxin-alpha; D011506:Proteins; D011956:Receptors, Cell Surface; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D008071:Lipoprotein Lipase