Heterotransplantation of human pleomorphic adenomas to nude mice.
The purpose of the present study was to establish a model for in vivo studies of human pleomorphic adenomas by heterotransplantation of tumour tissue to nude mice. Tissue from 7 tumours was transplanted to a total of 34 mice. Take with obvious growth occurred in 12 mice, and survival of the tissue was seen in an additional 8 mice. The overall histological picture was unchanged from the donor tumours to the transplanted tissue. The possibilities of the model are discussed.
D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000328:Adult; D000368:Aged; D000818:Animals; D062109:Dermatologic Surgical Procedures; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation; D010307:Parotid Neoplasms / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D013365:Submandibular Gland Neoplasms / Q000473:pathology; D014183:Transplantation, Heterologous