title: [Increased efficacy of teturam combined with L-DOPA in experimental alcoholism in the rat].
abstract: In an experiment on Wistar male rats the authors studied the effects of teturam, diethyldithiocarbamate and Esperale in combination with L-DOPA on the consumption of alcohol and metabolism of biogenic amines in the brain. The use of L-DOPA prolonged the inhibitary effect of teturam on alcohol consumption. The administration of L-DOPA following Esperale implantation prevented the development of the abstinence syndrome. An increase in the efficacy of teturam and Esperale under the effect of L-DOPA was attended by elevated synthesis of cerebral noradrenaline.
mesh_terms: D000427:Alcohol Deterrents / Q000008:administration & dosage*; D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D004221:Disulfiram / Q000008:administration & dosage*; D004050:Ditiocarb / Q000008:administration & dosage; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007980:Levodopa / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000427:Alcohol Deterrents; D002395:Catecholamines; D007980:Levodopa; D004050:Ditiocarb; D004221:Disulfiram
vernacular_title: Povyshenie éffektivnosti teturama s pomoshch'iu L-DOFA pri éksperimental'nom alkogolizme.