Conditioned slowing of stomach emptying produced by Pavlovian pairings of a drug CS or a place with lithium chloride.
Lithium chloride, in common with other drugs with emetic effects, prolongs stomach emptying. In different experiments, a drug state induced by a low dose of pentobarbital in Experiment 1 and morphine in Experiment 2 or a distinctive place (Experiments 3, 4) was the conditioned stimulus paired with lithium chloride as the unconditioned stimulus. In each case, Pavlovian conditioning occurred and the conditioned response mimicked lithium's unconditioned effect on stomach emptying.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D004435:Eating / Q000187:drug effects; D005746:Gastric Emptying / Q000187:drug effects*; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride