[Piracetam correction of deficient GABA-ergic inhibition due to early postnatal exposure to cycloheximide].
Cycloheximide, administered to 7-day-old rats, caused the delay of CNS activity changes in grown-up rats. The animals showed impaired memory function, expressed in the decrease of habituation in the "open field" test, and the alteration of passive avoidance reflex. The increased number of intersignal reactions due to hypermotility was found during elaboration of avoidance reflex. The analysis of evoked potential recovery revealed the deficiency of GABA-ergic inhibition in the neocortex. Piracetam was shown to prevent completely behavioural disturbances and deficiency of GABA-ergic processes in grown-up animals.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects; D003513:Cycloheximide / Q000494:pharmacology*; D004924:Escape Reaction / Q000187:drug effects; D007552:Isotonic Solutions; D007858:Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D009433:Neural Inhibition / Q000187:drug effects*; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D012965:Sodium Chloride / Q000494:pharmacology; D013997:Time Factors
D007552:Isotonic Solutions; D011760:Pyrrolidinones; D011963:Receptors, GABA-A; D012965:Sodium Chloride; D003513:Cycloheximide; D010889:Piracetam
Korrektsiia piratsetamom defitsita GAMK-ergicheskogo tormozheniia, vyzvannogo rannim postnatal'nym vozdeĭstviem tsiklogeksemida.