Group B coxsackieviruses readily establish persistent infections in human lymphoid cell lines.
Exposing human lymphoid cell lines to uncloned or recently cloned group B coxsackieviruses results in the frequent establishment of chronically infected cultures. Persistence is maintained by a carrier culture mechanism involving virus spread through the medium and replication among a minority of cells at any given time. These studies provide a model for persistence by highly cytocidal viruses.
D002460:Cell Line; D029822:Enterovirus B, Human / Q000254:growth & development*; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology*; D014779:Virus Replication