title: Human prion protein cDNA: molecular cloning, chromosomal mapping, and biological implications.
abstract: A human complementary DNA whose protein product is considered to be the major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome has been identified and characterized. The extensive homology of this gene sequence to the hamster PrP 27- to 30-kilodalton prion protein complementary DNA clone, and its existence as a single copy in the human genome, leads to the conclusion that this is the human prion gene. This human prion gene has been mapped to human chromosome 20, negating a direct link between the prion protein and Down's syndrome or the amyloid of Alzheimer's disease.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002903:Chromosomes, Human, 19-20; D002904:Chromosomes, Human, 21-22 and Y; D003001:Cloning, Molecular; D007562:Creutzfeldt-Jakob Syndrome / Q000235:genetics / Q000382:microbiology; D006224:Cricetinae; D004247:DNA / Q000032:analysis*; D004262:DNA Restriction Enzymes / Q000378:metabolism; D006801:Humans; D011328:Prions / Q000235:genetics*; D014764:Viral Proteins / Q000032:analysis
chemical_list: D011328:Prions; D014764:Viral Proteins; D004247:DNA; D004262:DNA Restriction Enzymes