[Monoacylglycerol phosphatide accumulation and the alteration of the properties of benzodiazepine receptors in the brain synaptosomes].
Phospholipase A2-induced changes in the affinity of benzodiazepine receptors are due to accumulation of monoacylglycerol phosphatides, and not fatty acids, in the membranes. The data show the regulatory role of membrane phospholipids in ligand-receptor interaction.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism*; D003975:Diazepam / Q000378:metabolism; D004347:Drug Interactions; D005989:Glycerides / Q000378:metabolism*; D008024:Ligands; D008244:Lysophosphatidylcholines / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism*
D001095:Arachidonic Acids; D005989:Glycerides; D008024:Ligands; D008244:Lysophosphatidylcholines; D008563:Membrane Lipids; D010743:Phospholipids; D011963:Receptors, GABA-A; D016718:Arachidonic Acid; D010741:Phospholipases A; D054467:Phospholipases A2; D003975:Diazepam
Nakoplenie monoatsilglitserofosfatidov i izmenenie svoĭstv benzodiazepinovykh retseptorov v sinaptosomakh mozga.