title: Electron microscopy of Leishmania donovani in splenic aspirates from patients with visceral leishmaniasis during treatment with sodium stibogluconate.
abstract: Studies were made of the ultrastructure of amastigotes of Leishmania donovani before and during treatment of patients with sodium stibogluconate. The most consistent effects of treatment on the amastigotes were a reduction in average size, greater irregularity of the cell outline, and a moderate increase in the electron density of the cytoplasm associated with a greater concentration of ribosomes. It is suggested that the drug affects active transport functions or permeability of the plasma membrane.
mesh_terms: D000293:Adolescent; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D005942:Gluconates / Q000627:therapeutic use*; D006801:Humans; D007893:Leishmania donovani / Q000648:ultrastructure*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D012270:Ribosomes / Q000648:ultrastructure; D013154:Spleen / Q000469:parasitology* / Q000648:ultrastructure; D014617:Vacuoles / Q000648:ultrastructure
chemical_list: D005942:Gluconates; D000967:Antimony Sodium Gluconate