[Neurochemical mechanisms of the analgesic effect of L-DOPA].
Experiments on alert rats have shown that, with pre-inhibition of peripheral DOPA-decarboxylase, L-DOPA suppresses behavioral nociceptive reactions without changing hemodynamic ones. Analgetic effect of L-DOPA appears to be related to the stimulation of brain postsynaptic alpha1-adrenoceptors and the drug action on opioidergic systems.
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D007980:Levodopa / Q000494:pharmacology*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects
D000700:Analgesics; D011942:Receptors, Adrenergic, alpha; D011957:Receptors, Opioid; D007980:Levodopa
Neĭrokhimicheskie mekhanizmy boleutoliaiushchego deĭstviia L-DOFA.