title: Scrotal malignancies: the University of Iowa experience and a review of the literature.
abstract: Cancer of the scrotum is of special interest, despite its relative infrequency, because of its surprising virulence and also by virtue of its historical importance. This was the first known occupational cancer and showed the need for research involving potential environmental carcinogens. No one individual has sufficient experience to randomize patients to different methods of treatment, and the disease is becoming even less common. Therefore, recommendations are often based on compilations from the literature, many reports being fifty to one hundred fifty years old. This report reviews the clinical features of scrotal malignancies and the forty-five-year experience with this disease at the University of Iowa.
mesh_terms: D000328:Adult; D000368:Aged; D002280:Basal Cell Carcinoma / Q000209:etiology / Q000473:pathology / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000266:history / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D004739:England; D005354:Fibrosarcoma / Q000209:etiology / Q000473:pathology / Q000628:therapy; D005834:Genital Neoplasms, Male / Q000139:chemically induced / Q000266:history / Q000473:pathology / Q000628:therapy; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D007492:Iran; D008297:Male; D008545:Melanoma / Q000453:epidemiology / Q000628:therapy; D008875:Middle Aged; D009367:Neoplasm Staging; D009784:Occupational Diseases / Q000139:chemically induced / Q000266:history; D010145:Paget Disease, Extramammary / Q000473:pathology / Q000628:therapy; D012509:Sarcoma / Q000266:history / Q000473:pathology / Q000628:therapy; D012611:Scrotum / Q000473:pathology; D014481:United States