Multiple hepatic adenomas after long-term therapy with testosterone enanthate. Review of the literature.
We report a case of multiple hepatic adenomas developed in a 32-year-old man with renal allograft after long-term therapy with testosterone enanthate. Histological assessment showed a benign hepatocellular adenoma, which has not regressed over a 6-month follow-up since androgen withdrawal. A review of primary hepatic tumors associated with androgenic-anabolic steroid therapy published in the English literature has been carried out, concentrating on the more relevant recent publications. No previous case of hepatic adenoma with possible relationship to the use of non-17-alpha alkylated compounds has been reported.
D000328:Adult; D045930:Anabolic Agents / Q000009:adverse effects; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced*; D006801:Humans; D016030:Kidney Transplantation; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced*; D009394:Nephritis, Hereditary / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013739:Testosterone / Q000009:adverse effects / Q000031:analogs & derivatives*; D013997:Time Factors
D045930:Anabolic Agents; D013739:Testosterone; C004648:testosterone enanthate