Incorporation of synthetic 1,2-diacylglycerol into platelet phosphatidylinositol is increased by cyclic AMP.
1,2-Didecanoylglycerol (diC10) is taken up by human platelets and sequentially converted to 1,2-didecanoylphosphatidic acid (PA10) and 1,2-didecanoylphosphatidylinositol (PI10). Agents that increase cyclic AMP in platelets, such as prostacyclin and forskolin, sequentially convert diC10 to PA10 and PI10. They decrease formation of PA10 with a parallel accumulation of PI10. This might reflect an inhibition of phosphatidylinositol kinase.
D001792:Blood Platelets / Q000378:metabolism*; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology; D004075:Diglycerides / Q000378:metabolism*; D011464:Epoprostenol / Q000494:pharmacology; D005989:Glycerides / Q000378:metabolism*; D006801:Humans; D010712:Phosphatidic Acids / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*
D004075:Diglycerides; D005989:Glycerides; D010712:Phosphatidic Acids; D010716:Phosphatidylinositols; D005576:Colforsin; D011464:Epoprostenol; D000242:Cyclic AMP