Abelson virus drives the differentiation of Harvey virus-infected erythroid cells.
Abelson murine leukemia virus (A-MuLV) and Harvey murine sarcoma virus (Ha-MSV) are retroviruses carrying unrelated onc genes. However, both of these viruses are capable of stimulating the growth and differentiation of erythroid precursor cells; the target cells for both appear at the same time during fetal development and follow a similar pattern throughout ontogeny. In addition, the colonies induced by each virus are morphologically similar and synthesize the adult form of hemoglobin. However, A-MuLV-infected cells are Epo-independent, whereas Ha-MSV-infected cells are Epo-dependent. Superinfection of Ha-MSV-infected cells with A-MuLV overrides their Epo-dependency. Thus, the consequences of the infection are determined by the interaction of the different onc gene products with identical or similar erythroid cells.
D000011:Abelson murine leukemia virus / Q000235:genetics*; D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D004912:Erythrocytes / Q000382:microbiology; D004920:Erythropoiesis; D004921:Erythropoietin / Q000502:physiology*; D006251:Harvey murine sarcoma virus / Q000235:genetics*; D006454:Hemoglobins / Q000096:biosynthesis; D009052:Leukemia Virus, Murine / Q000235:genetics*; D008214:Lymphocytes / Q000382:microbiology; D051379:Mice; D009053:Sarcoma Viruses, Murine / Q000235:genetics*; D014018:Tissue Distribution
D006454:Hemoglobins; D004921:Erythropoietin