Acute polybrominated biphenyl toxicosis alters vitamin A homeostasis and enhances degradation of vitamin A.
A single oral dose of HBB (3,3',4,4',5,5',-hexabromobiphenyl), a congener of the polybrominated biphenyls (PBBs), and a dioxin-type cytochrome P-450 enzyme inducer rapidly and dramatically altered the steady-state metabolism of vitamin A and caused an abnormal twofold enhancement in the metabolic output of degraded vitamin A in urine and feces of rats. The effects are most likely explained by an increased metabolism of vitamin A in kidney and deregulation of vitamin A metabolism in liver; this may lead to an increased dietary vitamin A requirement.
D000818:Animals; D005243:Feces / Q000032:analysis; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D011075:Polybrominated Biphenyls / Q000506:poisoning*; D051381:Rats; D011919:Rats, Inbred Strains; D014801:Vitamin A / Q000378:metabolism* / Q000652:urine
D011075:Polybrominated Biphenyls; D014801:Vitamin A