The role of catecholestrogens in placental steroidogenesis.
The effect of the catecholestrogen, 2-hydroxyestrone (2-OHE1), on placental steroidogenesis was studied by incubating 2-OHE1 with placental explants for 24 hours and measuring the output of estradiol (E2) and progesterone (P4). 2-OHE1 stimulated the accumulation of E2 and P4 in the media. This effect was inhibited by the alpha-adrenergic blocker, phenoxybenzamine, and the beta-adrenergic blocker, propranolol. We conclude that 2-OHE1 affects placental steroidogenesis and that this effect could possibly be mediated through adrenergic receptors.
D004958:Estradiol / Q000096:biosynthesis; D004970:Estrone / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D006894:Hydroxyestrones / Q000494:pharmacology*; D066298:In Vitro Techniques; D010643:Phenoxybenzamine / Q000494:pharmacology; D010920:Placenta / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D011374:Progesterone / Q000096:biosynthesis; D011433:Propranolol / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013256:Steroids / Q000096:biosynthesis*
D006894:Hydroxyestrones; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D013256:Steroids; D010643:Phenoxybenzamine; D004970:Estrone; D011374:Progesterone; D004958:Estradiol; D011433:Propranolol; C024980:2-hydroxyestrone