Assays of sulbactam in the presence of ampicillin.
Three assays for sulbactam, a beta-lactamase inhibitor, in serum in the presence of ampicillin were compared. A synergistic bioassay, a gas chromatographic assay with detection by mass spectrometry, and a high performance liquid chromatography assay were similar with respect to both accuracy and precision.
D000667:Ampicillin / Q000097:blood / Q000494:pharmacology*; D001681:Biological Assay; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004357:Drug Synergism; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D010397:Penicillanic Acid / Q000097:blood*; D013407:Sulbactam; D065093:beta-Lactamase Inhibitors
D065093:beta-Lactamase Inhibitors; D000667:Ampicillin; D010397:Penicillanic Acid; D013407:Sulbactam