title: Effect of exogenous corticosteroids on circulating virus and neutralizing antibodies in striped bass (Morone saxatilis) infected with infectious pancreatic necrosis virus.
abstract: Corticosteroids have been reported to induce immunosuppression in fish exposed to many types of bacterial antigens. We document a similar phenomenon in fish exposed to infectious pancreatic necrosis virus (IPNV). Fingerling striped bass that were injected with the steroid triamcinolone acetonide (100 mg/kg body weight) 24 hours before receiving intraperitoneal inoculation with IPNV became viremic 3 days post inoculation (dpi) and virus was still detected in the buffy coat cells 14 dpi. In contrast, viremia could not be detected after 7 dpi in fish that received virus but not steroids. Circulating virus neutralizing antibodies were first detected in steroid treated fish at 10 dpi compared to 7 dpi for the virus injected fish and titers were consistently lower in the steroid group. Steroid treatment of chronic IPNV-carriers did not induce detectable viremia nor alter circulating antibody levels in chronic IPNV-carriers. None of the striped bass demonstrated clinical signs of viral disease.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D005393:Fish Diseases / Q000276:immunology* / Q000382:microbiology; D005399:Fishes; D012087:Reoviridae; D012088:Reoviridae Infections / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D014222:Triamcinolone Acetonide / Q000494:pharmacology*; D014766:Viremia
chemical_list: D000914:Antibodies, Viral; D014222:Triamcinolone Acetonide