Effect of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphonuclear cells.
The effect of pentoxifylline (Trental) on the phagocytic capacity, cAMP levels, and superoxide anion production of human peripheral blood monocytes and polymorphonuclears (PMNs) was studied. The drug inhibited the phagocytosis of latex particles by both monocytes and PMNs in a dose-dependent manner. In addition, superoxide anion production during the phagocytic process was also reduced following incubation of the cells with pentoxifylline. It is suggested that this inhibitory effect is due to the increased intracellular levels of cAMP induced by the drug.
D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D007840:Latex; D008863:Microspheres; D009000:Monocytes / Q000502:physiology*; D009504:Neutrophils / Q000502:physiology*; D010431:Pentoxifylline / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects; D013481:Superoxides / Q000378:metabolism; D013805:Theobromine / Q000031:analogs & derivatives*; D013997:Time Factors
D007840:Latex; D013481:Superoxides; D000242:Cyclic AMP; D013805:Theobromine; D010431:Pentoxifylline