Effects of an extract of Ginkgo biloba on noradrenergic systems of rat cerebral cortex.
Oral treatment of rats with Ginkgo biloba extract (Gb) elicited a biphasic effect on normetanephrine (NMN) content of cerebral cortex; an initial decrease was evident after 45 minutes, followed by a marked increase that was evident after 14 days. Chronic treatment with Gb led to decreases in the density of 3H-dihydroalprenolol binding (after 27 days or 2 months) and in isoproterenol-stimulated adenylate cyclase activity (after 2 months) of the cerebral cortex. Taken together, these results indicate that the effects of Gb on the central beta-adrenergic system might be involved in its therapeutic actions.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D003000:Clonidine / Q000378:metabolism; D004082:Dihydroalprenolol / Q000378:metabolism; D007099:Imipramine / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D009647:Normetanephrine / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism
D010936:Plant Extracts; D011943:Receptors, Adrenergic, beta; D009647:Normetanephrine; D004082:Dihydroalprenolol; D000262:Adenylyl Cyclases; D003000:Clonidine; D007099:Imipramine; D009638:Norepinephrine