Susceptibility of avian B lymphocytes to retroviral infection parallels that of fibroblasts.
The ability of conventional virus receptors to mediate infection and transformation of immature B cells by the avian leukosis virus (ALV) was analyzed in chimeric chickens whose bursa of Fabricius contained a mixture of B cells from subgroup A virus receptor-positive and -negative chickens. The data indicate that factors that determine resistance of fibroblasts to ALV infection also apply to bursal cells and that other receptors expressed by B cells, i.e., antigen or mitogen receptors, do not initiate infection or transformation, at least not independent of conventional virus receptors.
D000818:Animals; D001353:Avian Leukosis / Q000382:microbiology; D001358:Avian Sarcoma Viruses / Q000254:growth & development*; D001402:B-Lymphocytes / Q000382:microbiology*; D002060:Bursa of Fabricius / Q000382:microbiology; D002645:Chickens / Q000382:microbiology; D002678:Chimera; D005347:Fibroblasts / Q000382:microbiology*; D008113:Liver Neoplasms / Q000556:secondary; D011991:Receptors, Virus / Q000502:physiology
D011991:Receptors, Virus