title: Japanese encephalitis virus latency following congenital infection in mice.
abstract: Latent Japanese encephalitis virus (JEV) infection was shown in inapparently congenitally infected Swiss albino mice after their mothers had been given JEV intraperitoneally during pregnancy. Only one of 37 (2.7%) of the baby mice showed persistence of infectious virus at 5 weeks of age. Reactivation of JEV in Swiss albino mice was demonstrated by stimulation with allogeneic spleen cells from Parks strain mice at 21 weeks of age; reactivation was demonstrated in 41% of the inapparently infected mice. The spleen cells of congenitally infected mice had depressed [3H]thymidine uptake following stimulation with concanavalin A, and depressed ability to induce a graft-versus-host response.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001921:Brain / Q000382:microbiology; D004664:Encephalitis Virus, Japanese / Q000302:isolation & purification / Q000472:pathogenicity*; D004672:Encephalitis, Japanese / Q000196:embryology*; D005260:Female; D007075:Immunoglobulin M / Q000032:analysis; D008431:Maternal-Fetal Exchange; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M