A new homeo-box is present in overlapping cosmid clones which define the mouse Hox-1 locus.
A new murine homeo-box (Hox1-3) has been isolated and studied with respect to its structure and transcriptional pattern. This homeo-box is part of a gene which is specifically regulated during mouse prenatal development and expressed in a restricted number of teratocarcinoma tumours as well as in adult testis. Hox1-3 is shown to be a member of a cluster of at least four homeo-boxes lying within a 75-kb segment of DNA on mouse chromosome 6. The structure of the whole cluster, the Hox-1 locus is presented.
D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D003360:Cosmids; D004262:DNA Restriction Enzymes; D004330:Drosophila / Q000235:genetics; D004622:Embryo, Mammalian; D004625:Embryo, Nonmammalian; D005260:Female; D005333:Fetus; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D009693:Nucleic Acid Hybridization; D011247:Pregnancy; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D013724:Teratoma / Q000235:genetics; D014158:Transcription, Genetic; D014981:Xenopus
D004262:DNA Restriction Enzymes