Specific desensitization in the cytoskeletal assembly of platelet by receptor-dependent activations.
Cytoskeletal assembly induced by receptor-dependent or independent activation of bovine platelets was investigated. When platelets were preactivated with receptor-dependent stimulus, ADP or thrombin, cytoskeletal assembly was not induced repeatedly by the same agonist. However, in the case of receptor-independent stimulus, cryo-activation, the assembly was induced not only by receptor-dependent but also by independent stimulus. The desensitization, therefore, lies in the transmission of stimuli from receptors to cytoskeletal proteins.
D000199:Actins / Q000097:blood; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002352:Carrier Proteins / Q000097:blood; D002417:Cattle; D003080:Cold Temperature; D003599:Cytoskeleton / Q000378:metabolism*; D018260:Gelsolin; D066298:In Vitro Techniques; D008840:Microfilament Proteins; D009218:Myosins / Q000097:blood; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism; D013917:Thrombin / Q000494:pharmacology
D000199:Actins; D002352:Carrier Proteins; D018260:Gelsolin; D008840:Microfilament Proteins; D011956:Receptors, Cell Surface; C016953:brevin; D000244:Adenosine Diphosphate; D013917:Thrombin; D009218:Myosins