Differential effects of antidepressant drugs on [3H]dihydroalprenolol and [3H]imipramine ligand recognition sites in olfactory bulbectomized and sham-lesioned rats.
In the olfactory bulbectomy rat model of major depression, the binding of [3H]imipramine is increased by 60% in the midbrain, reduced by 30% in the pons and by 20% in the hippocampus, and unchanged in the hypothalamus 6 weeks after the bulbectomy. Binding of [3H]dihydroalprenolol is unchanged in the midbrain but is increased by 30% in the pons and 15% in the hippocampus. The i.p. administration of the antidepressants amitriptyline, mianserin, tranylcypromine (all at a dose of 10 mg/kg) or iprindole (25 mg/kg) for 28 days followed by a 5-day drug washout period, alters brain part [3H]imipramine and [3H]dihydroalprenolol binding in a manner that is a function of the particular drug, brain part and lesion effect. Only in the hippocampus did the lesion increase beta-binding that was reduced by all four antidepressant drugs.
D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002352:Carrier Proteins; D007488:Iprindole / Q000494:pharmacology; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D009830:Olfactory Bulb / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D013997:Time Factors; D014191:Tranylcypromine / Q000494:pharmacology
D000928:Antidepressive Agents; D002352:Carrier Proteins; D011943:Receptors, Adrenergic, beta; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C028413:dihydroalprenolol receptor; C027775:imipramine receptor; D000639:Amitriptyline; D008803:Mianserin; D014191:Tranylcypromine; D007488:Iprindole