title: Effect of amino acids on the expression of antiviral activity of different types of human interferon. I. Effect of single amino acids.
abstract: It has been observed that certain amino acids may influence the antiviral activity of different types of human interferon (IFN). The effect may be enhancing or inhibitory. A qualitative survey is provided on all three types of human IFN using 23 different amino acids. A more detailed study was carried out with 10 amino acids which proved to be active towards HuIFN-alpha. Their influences on the synergistic antiviral effects of HuIFN-alpha and HuIFN-gamma were also investigated. The dose-dependence curves of their effects on HuIFN-alpha were established.
mesh_terms: D000596:Amino Acids / Q000494:pharmacology*; D000650:Amnion; D002460:Cell Line; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D007700:Kinetics; D011247:Pregnancy; D013329:Structure-Activity Relationship; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects*
chemical_list: D000596:Amino Acids; D007370:Interferon Type I; D007371:Interferon-gamma