LANT-6, xenopsin and neuromedin N stimulate cyclic GMP at neurotensin receptors.
The naturally occurring analogs of neurotensin-(8-13), xenopsin, [Lys8,Asn9]neurotensin-(8-13) (LANT-6) and neuromedin N stimulated the production of intracellular cyclic GMP in murine neuroblastoma clone N1E-115, an adrenergic neuronal cell type. The order of potency was neurotensin-(8-13) greater than neurotensin greater than xenopsin greater than neuromedin N greater than LANT-6. Furthermore, xenopsin, LANT-6 and neuromedin N each inhibited the specific binding of [3H]neurotensin to intact N1E-115 cells in a dose-related fashion. The order of affinity of the peptides for the neurotensin receptor was neurotensin-(8-13) greater than xenopsin greater than neurotensin greater than neuromedin N greater than LANT-6.
D000818:Animals; D002999:Clone Cells; D006152:Cyclic GMP / Q000096:biosynthesis*; D051379:Mice; D009447:Neuroblastoma / Q000378:metabolism; D009496:Neurotensin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D010455:Peptides; D018028:Receptors, Neurotensin; D017981:Receptors, Neurotransmitter / Q000187:drug effects* / Q000378:metabolism; D029867:Xenopus Proteins
D009842:Oligopeptides; D010446:Peptide Fragments; D010455:Peptides; D018028:Receptors, Neurotensin; D017981:Receptors, Neurotransmitter; D029867:Xenopus Proteins; C042090:neuromedin N; D009496:Neurotensin; C016832:xenopsin; C037243:neurotensin-related hexapeptide; D006152:Cyclic GMP