Isolation of angiotensin-converting enzyme inhibitor from porcine plasma.
An inhibitory peptide of angiotensin-converting enzyme was purified from porcine plasma. The final preparation showed IC50 values of 4.2, 0.6, and 0.9 microgram/ml for angiotensin-converting enzymes from guinea pig serum, rabbit lung, and monkey brain, respectively. The amino acid sequence of the inhibitor was determined as leucyl-valyl-leucine by Edman procedure. This structural observation was supported by mass spectrometric analysis.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D009842:Oligopeptides / Q000097:blood* / Q000302:isolation & purification / Q000494:pharmacology; D013552:Swine
D000596:Amino Acids; D000806:Angiotensin-Converting Enzyme Inhibitors; D009842:Oligopeptides