Identification of a protease gene of human T-cell leukemia virus type I (HTLV-I) and its structural comparison.
We determined the nucleotide sequence of a region between the gag and pol genes of a replication-competent proviral clone of a human T-cell leukemia virus type I (HTLV-I) from MT-2 cells. This region overlapping the gag and pol genes contains an open reading frame with a different phase from others. The deduced amino acid sequences show significant homology with the known protease gene of other retroviruses, and harbors highly conserved amino acid sequences that are well conserved in other retroviral protease domains. These results indicate that this open reading frame encodes a HTLV-I protease.
D000595:Amino Acid Sequence; D001483:Base Sequence; D003062:Codon; D017977:Deltaretrovirus / Q000235:genetics*; D015683:Gene Products, gag; D005814:Genes, Viral; D010447:Peptide Hydrolases / Q000032:analysis / Q000235:genetics*; D012191:Retroviridae Proteins / Q000235:genetics
D003062:Codon; D015683:Gene Products, gag; D012191:Retroviridae Proteins; D010447:Peptide Hydrolases