Translocation of protein kinase C activity may mediate hippocampal long-term potentiation.
Protein kinase C activity in rat hippocampal membranes and cytosol was determined 1 minute and 1 hour after induction of the synaptic plasticity of long-term potentiation. At 1 hour after long-term potentiation, but not at 1 minute, protein kinase C activity was increased twofold in membranes and decreased proportionately in cytosol, suggesting translocation of the activity. This time-dependent redistribution of enzyme activity was directly related to the persistence of synaptic plasticity, suggesting a novel mechanism regulating the strength of synaptic transmission.
D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D003600:Cytosol / Q000201:enzymology; D004789:Enzyme Activation; D006624:Hippocampus / Q000201:enzymology* / Q000502:physiology; D008297:Male; D009473:Neuronal Plasticity; D011493:Protein Kinase C / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D013570:Synaptic Membranes / Q000201:enzymology; D009435:Synaptic Transmission
D011493:Protein Kinase C