[Effects of a morphine-clomipramine combination on a test of experimental analgesia].
Morphine (2.5 mg/kg sc) i.e. at a non-antinociceptive dose, augmented clomipramine-induced antinociceptive effect but failed to alter the values of clomipramine (10, 20, 40 mg/kg orally) levels in rats. These results suggest that the potentiation of clomipramine-induced analgesia by morphine does not result from a peripheral pharmacokinetic mechanism but probably involves a central interaction between clomipramine and opiates pathways.
D000700:Analgesics; D000818:Animals; D002997:Clomipramine / Q000494:pharmacology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000378:metabolism
D000700:Analgesics; D011957:Receptors, Opioid; D009020:Morphine; D002997:Clomipramine
Effets de l'association morphine-clomipramine sur un test d'analgésie expérimentale.