title: Effects of enalaprilic acid on sodium excretion and renal hemodynamics in essential hypertension.
abstract: The effects of MK 422 (enalaprilic acid) on renal function and electrolyte excretion were assessed in 14 patients with essential hypertension on a sodium intake of 100 mmol/day. Injection of MK 422 led to a prompt fall in blood pressure (p less than 0.01). Effective renal plasma flow increased by 9 +/- 4% (p less than 0.01) within 1 hour, an increase that persisted for a least 5 hours. Glomerular filtration rate did not change, so filtration fraction decreased by 6 +/- 2% (p less than 0.01). Sodium excretion increased with a maximum of 61 +/- 17% (p less than 0.01) after 5 hours, and potassium excretion fell (p less than 0.01). The log of the initial plasma renin activity correlated with the changes in blood pressure (r = 0.59, p less than 0.05) in effective renal plasma flow (r = 0.59, p less than 0.05) and in sodium excretion (r = 0.65, p less than 0.01). All the renal effects of MK 422 could be reversed by infusion with angiotensin II.
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D004573:Electrolytes / Q000494:pharmacology; D004656:Enalapril / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D015773:Enalaprilat; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000652:urine*
chemical_list: D004573:Electrolytes; D004656:Enalapril; D012964:Sodium; D015773:Enalaprilat