Alpha-adrenergic modulation of cyclic AMP formation in rat CNS: highest level in olfactory bulb.
The cyclic adenosine monophosphate response to catecholamines in the rat brain is mediated by beta-adrenergic receptors which activate adenylate cyclase and by alpha-adrenergic receptors which potentiate the response to beta-stimulation. We have found that the alpha-potentiation effect in the olfactory bulb is 2-3X greater than in other forebrain areas. This correlates with the extremely high density of alpha-receptors in this brain region and makes it a useful model for the study of alpha-receptor function.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D000242:Cyclic AMP / Q000096:biosynthesis*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000031:analogs & derivatives / Q000494:pharmacology; D009830:Olfactory Bulb / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*
D011942:Receptors, Adrenergic, alpha; C024884:6-fluoronorepinephrine; D000242:Cyclic AMP; D007545:Isoproterenol; D009638:Norepinephrine