Need for hepatocellular carcinoma screening before renal transplantation in HBs +, HBe +, western African.
We report a case of fulminant hepatocellular carcinoma discovered 50 days after renal transplantation. The recipient was a young Senegalese, hepatitis B virus chronic carrier. The pre-transplant check-up was normal, and the tumor was latent until its dramatic expression. Progression of hepatitis B liver disease occurs in immuno-suppressed renal transplant recipients, which often leads to chronic active hepatitis, cirrhosis and hepatocellular carcinoma, with a high risk of death due to liver disease. The early discovery of the tumor in this patient emphasizes the necessity for complete hepatic screening before transplantation in african, hepatitis B virus chronic carrier recipients. Moreover, the accumulation of risk factors for hepatocellular carcinoma: hepatitis B virus, food mycotoxins (aflatoxin), parasitic infestation and immunosuppression with transplantation is stressed.
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D002353:Carrier State; D006509:Hepatitis B / Q000150:complications; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008113:Liver Neoplasms / Q000209:etiology*; D008297:Male; D012306:Risk; D012675:Senegal
D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens