Human chromosome 7 carries the beta 2 interferon gene.
A cDNA clone (pAE20-4) corresponding to the 1.3-kilobase human beta 2 interferon mRNA was used as a probe in blot-hybridization experiments of DNA from a panel of human-rodent somatic cell hybrids containing overlapping subsets of human chromosomes. The DNA hybridization experiments showed that the human beta 2 interferon gene is located on human chromosome 7. This assignment is consistent with previous experimental data in which the expression of the translationally active 1.3-kilobase beta 2 interferon mRNA was assayed in various somatic cell hybrids. Blot-hybridization experiments using DNA from different human cell strains and cell lines reveal distinct EcoRI restriction fragment length polymorphisms of the human beta 2 interferon gene.
D000818:Animals; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D006224:Cricetinae; D004247:DNA / Q000032:analysis; D004262:DNA Restriction Enzymes; D005796:Genes; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells / Q000032:analysis; D007370:Interferon Type I / Q000235:genetics*; D051379:Mice; D011110:Polymorphism, Genetic
D005819:Genetic Markers; D007370:Interferon Type I; D004247:DNA; D004262:DNA Restriction Enzymes