[Effect of selenium on the system of superoxide anion radical formation and detoxication in hepatocarcinogenesis].
It is established that the introduction of selenium in combination with diethylnitrosamine into rat organisms has a preventive influence on the tumour formation. The intensity of superoxide radicals formation by the liver cell microsomes in this case decreases, while the activity of superoxide dismutase, glutathione peroxidase I, glutathione reductase and concentration of selenium in microsomes increases. The anticarcinogenic action of selenium is considered as a result of an increase in the activity of superoxide dismutase, glutathione peroxidase I and glutathione reductase. This increase induces detoxication of superoxide radicals forming in considerable amounts in rat liver cells under the effect of carcinogen.
D000818:Animals; D004052:Diethylnitrosamine; D004789:Enzyme Activation / Q000187:drug effects; D005609:Free Radicals; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D008658:Inactivation, Metabolic; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D012643:Selenium / Q000378:metabolism / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*; D013997:Time Factors
D005609:Free Radicals; D013481:Superoxides; D004052:Diethylnitrosamine; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D012643:Selenium
Vliianie selena na sostoianie sistemy obrazovaniia i detoksikatsii superoksidnykh anion-radikalov pri gepatokantserogeneze.