title: Human papillomavirus types 6 and 16 in multifocal intraepithelial neoplasias of the female lower genital tract.
abstract: Five women with multifocal intraepithelial neoplasia of the lower genital tract were investigated for the presence of human papillomavirus (HPV) infection by the method of DNA-DNA hybridization which detects the viral DNA. The DNA sequences of HPV types 6 and 16 were detected in each of the five patients and in each of the areas biopsied: cervix, vagina and vulva. DNA sequences of both viral types were also found in vulval intraepithelial neoplasia grades I-III and in cervical intraepithelial neoplasia grades I and III. The detection of HPV DNAs in multifocal lesions suggests a possible common aetiology for the lower genital tract intraepithelial neoplasias.
mesh_terms: D000328:Adult; D003127:Colposcopy; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005833:Genital Neoplasms, Female / Q000235:genetics / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000382:microbiology*; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000302:isolation & purification; D014621:Vagina / Q000473:pathology; D014844:Vulva / Q000473:pathology
chemical_list: D004279:DNA, Viral