Antipicornavirus activity of substituted phenoxybenzenes and phenoxypyridines.
Phenoxybenzenes and phenoxypyridines were prepared and tested for the effect of substituents on antipicornavirus activity. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (8), demonstrated broad-spectrum antipicornavirus activity. Compound 8 and several analogues each given orally prior to and during infection protected mice against an otherwise lethal challenge with coxsackievirus A21.
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis*; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003384:Coxsackievirus Infections / Q000188:drug therapy; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004770:Enterovirus / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D010849:Picornaviridae / Q000187:drug effects*; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D012229:Rhinovirus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D001555:Benzene Derivatives; D011725:Pyridines