Virus-induced murine diabetes. Enhancement by immunosuppression.
Adult, male ICR Swiss mice are susceptible to the diabetogenic effects of the D-variant of encephalomyocarditis virus (EMC-D) in contrast to adult C3H/HeJ male mice, which are relatively resistant. To date, experimental evidence suggests that the immune system plays a role in the pathogenesis of this infection. We have investigated the potential involvement of the immune system in the pathogenesis of EMC-D-induced diabetes using cyclosporin-A (CyA), a potent immunosuppressive drug. The data show that treatment with CyA results in increased severity and incidence of diabetes in susceptible ICR Swiss mice and induction of diabetes in resistant C3H/HeJ mice. It is concluded that immune mediation probably is not involved in the early pathogenesis of EMC-D-induced diabetes in mice.
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D002648:Child; D003524:Cyclosporins / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D004686:Encephalomyocarditis virus / Q000276:immunology; D004769:Enterovirus Infections / Q000150:complications*; D005951:Glucose Tolerance Test; D006801:Humans; D007165:Immunosuppression Therapy; D007515:Islets of Langerhans / Q000382:microbiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008813:Mice, Inbred ICR; D051381:Rats
D000914:Antibodies, Viral; D003524:Cyclosporins