Evidence for reflex adrenergic inhibition of acid secretion in the conscious rat.
In conscious gastric fistula rats, gastric distension with saline to a pressure of 7 cm caused a threefold reduction of basal gastric acid secretion. Distension with 6.25% peptone solution to the same pressure doubled basal acid secretion. The saline distension-induced inhibition was abolished by guanethidine and markedly reduced by propranolol; phentolamine was ineffective. The response to peptone was unaffected by guanethidine. The results suggest that in the rat, gastric distension at physiological pressures inhibits acid secretion by a beta-adrenergic reflex. The inhibition can be masked by concurrent chemical stimulation of the gastric mucosa by the digestion products of food.
D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D005747:Gastric Fistula; D005753:Gastric Mucosa / Q000187:drug effects / Q000502:physiology; D006145:Guanethidine / Q000494:pharmacology; D006874:Hydrostatic Pressure; D007700:Kinetics; D008297:Male; D010461:Peptones / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012965:Sodium Chloride / Q000494:pharmacology; D012996:Solutions
D010461:Peptones; D011943:Receptors, Adrenergic, beta; D012996:Solutions; D012965:Sodium Chloride; D011433:Propranolol; D010646:Phentolamine; D006145:Guanethidine