Inhibition of reduction in the testicular weight by WR-2721 in relation to the body weight after whole-body gamma irradiation.
Male Swiss albino mice were irradiated with 60Co gamma rays at 3, 6 and 8 Gy dose levels in separate groups in the presence and absence of the radioprotective drug, WR-2721. The drug treated animals received intraperiotoneal injection of 400 mg/kg body weight aqueous solution (pH 6.2) of WR-2721. Animals were weighted and sacrificed at various post-irradiation intervals between day 1/4 to day 28. Testes were weighed for determining the testis/body weight ratios. The results indicated that testis/body weight ratio reduced after radiation exposure and the extent of this reduction depended on the dose of exposure. Injection of WR-2721 inhibited the body weight loss including the testicular mass loss after irradiation, as depicted by the significantly higher testis/body weight ratio in the drug pretreated animals.
D004999:Amifostine / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects* / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects* / Q000528:radiation effects; D013997:Time Factors; D014916:Whole-Body Irradiation
D009946:Organothiophosphorus Compounds; D004999:Amifostine