[Stimulation of adenyl cyclase and fixation of iodine in human cancerous thyroid cells in culture].
In primary cultures of cells from human thyroid cancer, functional activity was investigated by adenylate cyclase responsiveness and radioiodine uptake. In cells from well-differentiated follicular carcinomas (2 cases), TSH stimulation of cAMP accumulation is similar to that of normal thyroid cells. In contrast, in papillary carcinomas (11 cases), the mean dose-response curve is much lower than normal. In thyroid cancers, radioiodine uptake by the cells has been detected in some cases after 3 days of 125I incorporation. As previously observed, our results suggest the existence of a relationship between adenylcyclase responsiveness and 125I uptake by the cells.
D000230:Adenocarcinoma / Q000201:enzymology / Q000378:metabolism*; D000262:Adenylyl Cyclases / Q000378:metabolism*; D002291:Carcinoma, Papillary / Q000201:enzymology / Q000378:metabolism*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D006801:Humans; D007455:Iodine / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000201:enzymology / Q000378:metabolism*; D013972:Thyrotropin / Q000494:pharmacology*
D013972:Thyrotropin; D007455:Iodine; D000242:Cyclic AMP; D000262:Adenylyl Cyclases
Stimulation de l'adénylcyclase et fixation d'iode dans des cellules thyroïdiennes humaines cancéreuses en culture.