Effects of intracarotid ionic and non-ionic contrast material on the blood-brain barrier in a rabbit model.
A rabbit model was used to assess the effects of intracarotid injections of ionic monomer (meglumine iothalamate), non-ionic monomer (iohexol, iopromide), and non-ionic dimer (iotrol) contrast materials on the blood-brain barrier. The degree of blood-brain barrier damage was assessed qualitatively using Evans' blue dye, and quantitatively by calculating the difference in pertechnetate uptake between injected and non-injected hemispheres. The results showed that the non-ionic dimer, iotrol, had the least effect on the blood-brain barrier, and that although iopromide and iohexol produced greater damage than iotrol, the ionic compound, meglumine iothalamate, caused the greatest disruption to the blood-brain barrier. The implications of these findings are discussed.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002339:Carotid Arteries; D003287:Contrast Media / Q000494:pharmacology*; D005070:Evans Blue; D005260:Female; D007269:Injections, Intra-Arterial; D007472:Iohexol / Q000031:analogs & derivatives; D007482:Iothalamate Meglumine / Q000494:pharmacology; D008297:Male; D011817:Rabbits; D013670:Sodium Pertechnetate Tc 99m; D014283:Triiodobenzoic Acids / Q000494:pharmacology
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C033300:iotrolan; D007472:Iohexol; D005070:Evans Blue; C038192:iopromide; D013670:Sodium Pertechnetate Tc 99m; D007482:Iothalamate Meglumine