[Effect of prostaglandin E2 and its derivatives on the reaction of isolated mollusk neurons to acetylcholine].
A study was made of the effect of PGE2, ethyl ether and a carbohydrate derivative of PGE2 on the sensitivity to acetylcholine (ACh) of identified neurons of the mollusk pond snail. The response recorded in the mode of membrane potential fixation diminished in the presence of PGE2 and its derivatives. The rate of the decrease and the degree of the response blockade depended on the substance concentration. Washing of PGE2 made the neuronal sensitivity to ACh return to normal. With the use of PGE2 derivatives the sensitivity recovery was incomplete. The radioimmunochemical technique has demonstrated PGE2 to raise the cAMP level in the pond snail brain.
D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003470:Culture Media; D000242:Cyclic AMP / Q000378:metabolism; D015232:Dinoprostone; D066298:In Vitro Techniques; D008195:Lymnaea / Q000187:drug effects* / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D011458:Prostaglandins E / Q000494:pharmacology*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D011978:Receptors, Nicotinic / Q000187:drug effects*
D003470:Culture Media; D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; D011978:Receptors, Nicotinic; D000242:Cyclic AMP; D015232:Dinoprostone; D000109:Acetylcholine
Vliianie prostaglandina E2 i ego proizvodnykh na otvet izolirovannykh neĭronov molliuska na atsetilkholin.