Age-related changes of beta-adrenoceptors in aging inbred mice.
The density (Bmax) and antagonist dissociation constant (KD) of beta-adrenoceptors were determined on spleen and brain of three different inbred strains of mice--BALB/cJ, C3H/HeJ, and C57BL/6J. Receptor densities (Bmax) differed with strain and declined in both spleen and cortical receptor populations as mice became older. Age-related changes in KD were found on spleen cells of BALB/cJ and in the cortex of C3H/HeJ and C57BL/6J. Bmax and KD in different organs of the same strain changed at different rates. changed at different rates.
D000375:Aging; D000818:Animals; D002452:Cell Count; D002540:Cerebral Cortex / Q000378:metabolism; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D011943:Receptors, Adrenergic, beta / Q000032:analysis* / Q000235:genetics; D013154:Spleen / Q000166:cytology / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology
D011943:Receptors, Adrenergic, beta