title: Osteogenic sarcoma.
abstract: Guarded optimism could be clearly stated for the treatment of osteogenic sarcoma. Improved methods of diagnosis and staging have been made possible by the computed tomography (CT) scan and other new modalities. The advent of pre- and postoperative chemotherapy has significantly enhanced survival rates that are now approaching 85%. Improved concepts of en bloc resection and better reconstructive techniques suggest that limb salvage procedures are not only possible but can provide excellent functional results in the context of muscle loss. Continued work must be directed toward improving the reconstructive techniques to provide implants with permanence, particularly for young patients and to clearly define the indications for such procedures. Patients presenting with thoracic lesions, although difficult to treat, can expect a 30%--45% long-term survival following repetitive thoracotomies.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001186:Artificial Limbs; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005266:Femoral Neoplasms / Q000601:surgery; D006801:Humans; D006811:Humerus / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D010145:Paget Disease, Extramammary / Q000000981:diagnostic imaging / Q000601:surgery*; D011182:Postoperative Care; D011300:Preoperative Care; D011859:Radiography; D013125:Spinal Neoplasms / Q000601:surgery