Atropine- and tetrodotoxin-resistant motor activity, responsive to 4-aminopyridine, present in isolated rabbit jejunum.
The effects of 4-aminopyridine on the spontaneous contractile activity of rabbit jejunum segments were studied. Apart from its effects on the cholinergic component of the spontaneous activity, the drug was found to be effective to increase an atropine-, tetrodotoxin-resistant activity of the preparation, suggesting either a direct effect on intestinal smooth muscle cells or an indirect effect through an unidentified excitatory innervation.
D015761:4-Aminopyridine; D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004351:Drug Resistance; D066298:In Vitro Techniques; D007583:Jejunum / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D011817:Rabbits; D009435:Synaptic Transmission / Q000187:drug effects; D013779:Tetrodotoxin / Q000494:pharmacology
D000631:Aminopyridines; D013779:Tetrodotoxin; D001285:Atropine; D015761:4-Aminopyridine