An active chromatin structure acquired by translocated c-myc genes.
We used general sensitivity to DNase I digestion to analyze the chromatin structure of c-myc genes in seven murine plasmacytomas. In every case, the 3' portion of c-myc juxtaposed with C alpha displayed a much more DNase I-sensitive chromatin structure than untranslocated c-myc or, in one case analyzed, the reciprocally translocated 5' portion. Our data suggest the presence of regulatory sequences near the C alpha gene segment.
D000818:Animals; D002843:Chromatin / Q000502:physiology*; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D051379:Mice; D009857:Oncogenes; D010954:Plasmacytoma / Q000235:genetics*
D002843:Chromatin; D004262:DNA Restriction Enzymes