title: Course of clinical response to antidepressants.
abstract: The postulated pharmacological mechanisms of antidepressant effect are reviewed. The clinical profile of response to antidepressants are linked to the pharmacological mechanisms. The limitations of presently available instruments for diagnosis and measurement of change in depression are discussed.
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D010919:Placebos; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism
chemical_list: D000928:Antidepressive Agents; D010919:Placebos; D011942:Receptors, Adrenergic, alpha