The "Propins" test, a method for the estimation of the participation of the beta-adrenergic mechanism in ulcerogenesis.
In 12 ulcer patients in attack and in 6 healthy subjects the secretory test to insulin (Hollender test) was used and repeated after 48 hrs in association with propranolol (Propins test). While in controls the stimulated acid secretion was not influenced in ulcer patients a significant reduction of the secretory parameters was obtained in 60% of the cases thus confirming the existence of a beta-adrenergic component of the hydrochloric secretion. In 40% of the ulcer patients this effect was not observed. It therefore results that by using our "Propins" test it is possible to estimate the prevalence of the vagal-cholinergic or the beta-adrenergic (gastrinic) mechanism in the pathogenesis of duodenal ulcer.
D004381:Duodenal Ulcer / Q000503:physiopathology*; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D007328:Insulin; D011433:Propranolol; D011943:Receptors, Adrenergic, beta / Q000502:physiology
D007328:Insulin; D011943:Receptors, Adrenergic, beta; D011433:Propranolol