title: Functional significance of the serotoninergic influence on neuronal activity of the somatosensory cortex in 12-day-old kittens.
abstract: Monoamines, which participate in synaptic transmission as transmitters, also accomplish the modulation of neuronal activity. The role of serotonin (5-hydroxytryptamine--5-HT) was investigated in 8 to 14-day-old kittens by means of iontophoretic application onto neurones of the somatosensory cerebral cortex. The most typical response was the inhibition of neuronal activity. Another type of reaction was generated by inhibitory interneurones. After the microiontophoretic application of 5-HT, the tonic response of cortical neurones to the stimulation of the sciatic nerve changed into a phasic response. It is being suggested that the application of 5-HT to cortical neurones increases the excitability of inhibitory neurones. Hence, the serotoninergic regulation of neuronal activity in the somatosensory cortex may be operational from the 11th to the 12th day of postnatal life in cats.
mesh_terms: D000818:Animals; D002415:Cats; D004594:Electrophysiology; D007395:Interneurons / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology*; D013003:Somatosensory Cortex / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D012701:Serotonin