Comparative alpha- and beta-adrenoceptor activity of 2- and 6-ring-chlorinated noradrenaline analogues.
The alpha- and beta-adrenoceptor activity of the 2- and 6-ring-chlorinated analogues of noradrenaline (norepinephrine) were evaluated in vitro. The 2-chloro-substituted analogue exhibits a far greater affinity for beta 1-chronotropic receptors than the 6-chloro-substituted analogue, whereas no significant differences are apparent for their alpha-adrenergic affinities.
D000818:Animals; D001011:Aorta / Q000648:ultrastructure; D005260:Female; D006168:Guinea Pigs; D006325:Heart Atria / Q000648:ultrastructure; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism / Q000502:physiology*
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; C048740:2-chloronorepinephrine; C048741:6-chloronorepinephrine; D007545:Isoproterenol; D009638:Norepinephrine