[Blocking of Sindbis virus replication in the body of infected mice using an inhibitor of chymotrypsin-like proteases].
Parenteral administration of an inhibitor of chymotrypsin-like proteases (TPCK) to mice infected with alphavirus (Sindbis AR/339 strain) blocked virus replication in the brain and inhibited the development of viremia in the infected animals. The most likely mechanism of TPCK antiviral effect seems to consist in disturbance of proteolytic processing of viral proteins.
D000818:Animals; D001921:Brain / Q000382:microbiology; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D051379:Mice; D011480:Protease Inhibitors / Q000627:therapeutic use*; D012845:Sindbis Virus / Q000187:drug effects / Q000502:physiology; D013997:Time Factors; D014036:Togaviridae Infections / Q000188:drug therapy* / Q000382:microbiology; D014766:Viremia / Q000188:drug therapy / Q000382:microbiology; D014779:Virus Replication / Q000187:drug effects*
D011480:Protease Inhibitors; C049107:xylure; D002918:Chymotrypsin; D003857:Deoxyuridine
Blokirovanie replikatsii virusa Sindbis v organizme zarazhennykh mysheĭ s pomoshch'iu ingibitora khimotripsinpodobnykh proteaz.