[Optimization of the composition of the radioprotective complex APAETP+mexamine and analysis of its action].
The method of mathematical theory of experiment was used to find optimum variants of the radioprotective complex APAETP + mexamine. The character of their pharmacological interaction, depending on their dose ratio, was determined. It is suggested that it is conditioned by the specific role of different mechanisms involved in the radioprotective effect.
D008735:5-Methoxytryptamine / Q000008:administration & dosage*; D004999:Amifostine / Q000008:administration & dosage* / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D008297:Male; D051379:Mice; D009946:Organothiophosphorus Compounds / Q000008:administration & dosage*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents; D014018:Tissue Distribution; D014363:Tryptamines / Q000008:administration & dosage*
D004338:Drug Combinations; D009946:Organothiophosphorus Compounds; D011837:Radiation-Protective Agents; D014363:Tryptamines; D008735:5-Methoxytryptamine; D004999:Amifostine
Optimizatsiia sostava radiozashchitnoko kompleksa APAETF+meksamin i analiz ego deĭstviia.