title: Pathophysiology of cerebrospinal fluid in head injury: Part 2. Biochemical markers for central nervous system trauma.
abstract: Many substances are released into the cerebrospinal fluid after head injury. The study of these substances and their relationship to the severity and outcome of head trauma has lead to the search for biochemical markers to aid in the quantification of the severity of the lesion and serve as a prognostic guide. The authors review the potential usefulness of biochemical markers, qualities of an ideal marker, and several potential enzymes that may be utilized as markers in central nervous system trauma.
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000134:cerebrospinal fluid; D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000134:cerebrospinal fluid; D000263:Adenylate Kinase / Q000134:cerebrospinal fluid; D001930:Brain Injuries / Q000201:enzymology*; D003128:Coma / Q000201:enzymology; D003402:Creatine Kinase / Q000134:cerebrospinal fluid; D004798:Enzymes / Q000134:cerebrospinal fluid*; D006801:Humans; D007527:Isoenzymes; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid; D011379:Prognosis
chemical_list: D004798:Enzymes; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D000263:Adenylate Kinase; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D010751:Phosphopyruvate Hydratase