Concentration-related changes in blood and tissue parameters of hepatotoxicity and their interdependence in rats exposed to bromobenzene and 1,2-dichlorobenzene.
Liver damage resulting from 4 h exposure to bromobenzene (BB) (146-957 ppm) and 1,2-dichlorobenzene (DCB) (245-739 ppm) as model toxicants was evaluated in rats. The modifications considered were the increases in serum glutamate dehydrogenase (GLDH) and sorbitol dehydrogenase (SDH) activities and the decreases in centrolobular liver-cell glucose-6-phosphatase (G6-Pase) staining intensity. A linear inverse relationship was established between the logarithmic values of blood enzyme activities and liver G6-Pase staining intensity. In addition, the levels of exposure to each test chemical were found to be linearly related to liver G6-Pase staining intensity and to the logarithmic values of blood enzyme activities.
D000818:Animals; D001273:Atmosphere Exposure Chambers; D001969:Bromobenzenes / Q000633:toxicity*; D002722:Chlorobenzenes / Q000633:toxicity*; D005952:Glucose-6-Phosphatase / Q000096:biosynthesis / Q000097:blood*; D005969:Glutamate Dehydrogenase / Q000097:blood / Q000378:metabolism*; D007064:L-Iditol 2-Dehydrogenase / Q000096:biosynthesis / Q000097:blood*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013401:Sugar Alcohol Dehydrogenases / Q000097:blood*
D001969:Bromobenzenes; D002722:Chlorobenzenes; C004726:2-dichlorobenzene; C032036:bromobenzene; D013401:Sugar Alcohol Dehydrogenases; D007064:L-Iditol 2-Dehydrogenase; D005969:Glutamate Dehydrogenase; D005952:Glucose-6-Phosphatase