Effects of nitroprusside on pancreatic exocrine secretion and cyclic nucleotide concentration in the dog pancreas.
The effects of intravenous injection of nitroprusside on pancreatic exocrine secretion and on pancreatic cyclic AMP and cyclic GMP concentrations of mongrel dogs were investigated. Nitroprusside (10-100 micrograms/kg) increased the exocrine secretion together with the increase in cyclic GMP concentration dose dependently but did not affect the cyclic AMP concentration. These results suggest that nitroprusside causes exocrine secretion from the dog pancreas mediated through an increase of intracellular cyclic GMP concentration.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004285:Dogs; D005260:Female; D005292:Ferricyanides / Q000494:pharmacology*; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology*; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010189:Pancreatic Juice / Q000378:metabolism*
D005292:Ferricyanides; D009712:Nucleotides, Cyclic; D009599:Nitroprusside; D000242:Cyclic AMP; D006152:Cyclic GMP