title: Bioreactions at the tissue/hydroxyapatite interface.
abstract: The events at the hydroxyapatite implant material/tissue interface in the rat middle ear were studied by light microscopy, autoradiography, morphometry, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and X-ray microanalysis. Deposition of calcium, partially in the form of calcium phosphate, was found at the interface. Resorption of the implant material occurred as the result of mono- and multinuclear phagocyte activity. Resorption decreased 6 mnth after the operation, possibly due to the decreasing number of phagocytes at the interface and the increasing amount of bone in the macropores.
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D002118:Calcium / Q000378:metabolism; D017886:Durapatite; D004432:Ear, Middle; D004577:Electron Probe Microanalysis; D006882:Hydroxyapatites / Q000378:metabolism*; D008264:Macrophages / Q000502:physiology; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D010587:Phagocytosis; D019736:Prostheses and Implants; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006882:Hydroxyapatites; D017886:Durapatite; D002118:Calcium