Tifluadom-induced diuresis in rats. Evidence for an opioid receptor-mediated central action.
Tifluadom dose-dependently induced diuresis in rats after subcutaneous injection and oral application. (+)Tifluadom was at least 100-fold more potent than the (-)enantiomer in inducing diuresis. The diuretic action of tifluadom was dose-relatedly reduced by the opioid receptor antagonists naloxone and MR 2266. Naloxone methobromide did not antagonize the diuretic effect of tifluadom nor did the benzodiazepine receptor blocker Ro 15-1788. These data demonstrate that the diuretic effect of tifluadom is mediated centrally via an agonistic interaction between the drug and opioid receptors.
D000818:Animals; D001569:Benzodiazepines / Q000008:administration & dosage / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects; D013237:Stereoisomerism
D004232:Diuretics; D011963:Receptors, GABA-A; D011957:Receptors, Opioid; D001569:Benzodiazepines; C035470:tifluadom