title: Preliminary data on the encapsulation of biologically active materials in liposomes.
abstract: Multilamellar and unilamellar phospholipid liposomes were prepared and investigated as regards their properties and the capacity of encapsulating biologically active materials, such as CrO4-(2-)ions, basic dyes, proteins, DNA, as well as Sendai virus particles. The efficiency of encapsulation ranged from 10% for CrO4-(2-)ions to about 80% for toluidine blue; it was found to depend not only on the type of encapsulated material, but also on the method used for liposome preparation and on liposome composition.
mesh_terms: D000818:Animals; D002417:Cattle; D002840:Chromates / Q000494:pharmacology; D002876:Chromosomes, Bacterial; D004269:DNA, Bacterial / Q000494:pharmacology; D004347:Drug Interactions; D004926:Escherichia coli; D006801:Humans; D008081:Liposomes / Q000302:isolation & purification / Q000494:pharmacology*; D008722:Methods; D008970:Molecular Weight; D010222:Parainfluenza Virus 1, Human; D011370:Proflavine / Q000494:pharmacology; D012709:Serum Albumin / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013974:Thyroxine / Q000494:pharmacology; D014048:Tolonium Chloride / Q000494:pharmacology
chemical_list: D002840:Chromates; D004269:DNA, Bacterial; D008081:Liposomes; D012709:Serum Albumin; D014048:Tolonium Chloride; D012710:Serum Albumin, Bovine; D011370:Proflavine; D013974:Thyroxine