title: Transport properties of the lens.
abstract: Many studies have shown that the lens is a multicellular syncytial tissue whose electrophysiological properties are the integrated result of membrane transport, low-resistance gap junctions interconnecting the cells, and the restricted extracellular space between cells. There are at least three structurally distinct populations of cells within the lens, and the membrane transport properties of each cell type appear to differ. Indeed, there may be subcellular specialization of membrane transport properties in the surface epithelial cells. We review the physical structure of the lens, its electrical structure, and our present knowledge of the membrane transport properties of the different cell types. Our recent work has focused on radially circulating fluxes generated by the spatial localization of membrane transport in surface cell membranes versus inner fiber cell membranes. We review this work and present some simplified models of the results with some discussion of physiological implications.
mesh_terms: D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000502:physiology; D004553:Electric Conductivity; D004848:Epithelium / Q000502:physiology; D007908:Lens, Crystalline / Q000033:anatomy & histology / Q000378:metabolism*; D008433:Mathematics; D008564:Membrane Potentials; D008954:Models, Biological; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D000254:Sodium-Potassium-Exchanging ATPase