title: Dietary sodium bicarbonate as a treatment for exertional rhabdomyolysis in a horse.
abstract: A 3-year-old mare repeatedly had clinical signs of rhabdomyolysis on mild exertion. Serum creatine kinase and aspartate transaminase activities were high at rest. Responses to dietary sodium bicarbonate were tested through 7 alternating periods of supplementation of a basal ration of timothy hay and oats. Physical signs; venous blood pH and gases; blood glucose and lactate; serum electrolytes, enzymes, and creatinine; and urine pH were monitored before and after exercise. Dietary sodium bicarbonate raised resting venous blood pH and bicarbonate slightly and significantly increased urine pH from pH 7.46 to 8.2 (P less than 0.001). An exercise test included 5 minutes at the walk followed by 20 minutes at the trot. The exercise induced gait stiffness, muscle fasciculations, and muscle induration when the diet was not supplemented, but not when it was supplemented with sodium bicarbonate. Myoglobin was present in 16 of 21 urine samples after exercise during nonsupplemented periods, but only in 3 of 28 urine samples during supplemented periods (P less than 0.0001). Bicarbonate supplementation significantly decreased the responses of blood lactic acid, serum creatine kinase, and aspartate transaminase to exercise. Supplementation of the diet was associated with higher venous blood pH and bicarbonate ion concentrations throughout exercise. Dietary sodium bicarbonate apparently mitigated or prevented physical, chemical, and enzymatic characteristics of exertional rhabdomyolysis in this mare, possibly through its enhancement of buffering capacity in muscle tissue fluids.
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001639:Bicarbonates / Q000097:blood / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D003402:Creatine Kinase / Q000097:blood; D004032:Diet; D005260:Female; D006734:Horse Diseases / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006736:Horses; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood; D005082:Physical Exertion; D012206:Rhabdomyolysis / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D012964:Sodium / Q000627:therapeutic use*; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D001786:Blood Glucose; D007773:Lactates; D017693:Sodium Bicarbonate; D012964:Sodium; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase