Molecular size of alpha 1- and beta-adrenoceptors in rat brain cortex as determined by a radiation inactivation method.
Frozen whole rat cerebral cortex was exposed to 10 MeV electrons from a linear accelerator. Based on the theory of target size analysis, the in situ molecular weight of alpha 1-adrenoceptors (labelled by [3H]prazosin) and beta-adrenoceptors (labelled by [3H]dihydroalprenolol) was 57 800 daltons and 42 600 daltons, respectively.
D000818:Animals; D002540:Cerebral Cortex / Q000032:analysis* / Q000528:radiation effects; D004082:Dihydroalprenolol; D004583:Electrons; D007700:Kinetics; D008297:Male; D008566:Membranes / Q000032:analysis; D008970:Molecular Weight; D011224:Prazosin; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000032:analysis* / Q000528:radiation effects; D011943:Receptors, Adrenergic, beta / Q000032:analysis* / Q000528:radiation effects
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D011224:Prazosin