Accumulation of hepatic collagen following long-term administration of sake to rats.
Sake, a rice wine, induced hepatic collagen accumulation in rats. This was noted after 16 weeks of a liquid diet containing 35% ethanol by caloric content. However, under similar experimental conditions, whiskey and ethanol did not produce any changes. Hepatic collagenase activities in sake-fed rats were slightly, but significantly, higher than in the whiskey group. The central and pericellular liver fibrosis in sake-fed rats was caused possibly by either accelerated collagen synthesis or maturation, exceeding the increased collagen degradation. Mechanisms of enhanced fibrogenesis in sake-fed rats were discussed.
D000079:Acetaldehyde / Q000097:blood; D000410:Alanine Transaminase / Q000097:blood; D000434:Alcoholic Beverages / Q000633:toxicity*; D000818:Animals; D003094:Collagen / Q000378:metabolism*; D000431:Ethanol / Q000097:blood / Q000633:toxicity; D008099:Liver / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000209:etiology / Q000378:metabolism; D008297:Male; D003012:Microbial Collagenase / Q000378:metabolism; D008930:Mitochondria, Liver / Q000201:enzymology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000431:Ethanol; D003094:Collagen; D000410:Alanine Transaminase; D003012:Microbial Collagenase; D000079:Acetaldehyde