Phospholipids and sialic acid changes produced by vitamin D3 on intestinal mitochondria.
Vitamin D3 administration to vitamin D-deficient chicks produces, 24 hours after treatment, a large increment of phospholipids in mitochondria from intestinal mucosa. Proportion of the different phospholipid classes and fatty acid composition of the organelles were not modified by that treatment. A time course study of the effects of 1,25(OH)2D3 on calcium absorption and sialic acid content of intestinal mitochondria glycoproteins showed that both effects were correlated. The results suggest that either vitamin D or the increase of calcium transfer are involved in the make up of intestinal mitochondria membranes.
D000818:Animals; D002117:Calcitriol / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D002645:Chickens; D002762:Cholecalciferol / Q000494:pharmacology*; D006023:Glycoproteins / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D019158:N-Acetylneuraminic Acid; D010743:Phospholipids / Q000378:metabolism*; D012794:Sialic Acids / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000378:metabolism
D006023:Glycoproteins; D010743:Phospholipids; D012794:Sialic Acids; D002762:Cholecalciferol; D002117:Calcitriol; D019158:N-Acetylneuraminic Acid; D002118:Calcium