The etiology of underlying liver lesions in 70 autopsied cases of hepatocellular carcinoma.
In 70 patients with hepatocellular carcinoma without history of antineoplastic chemotherapeutic drugs, anabolic and contraceptive steroids, representative sections of nonneoplastic liver tissue were examined for the presence of etiological markers. Hepatitis B surface antigen-positive hepatocytes were found in 16 (22.8%), alpha-1-antitrypsin globules in 3 (4.2%), Mallory bodies in 9 (12.8%), acicular inclusions in 1 (1.4%), diffuse giant mitochondria in 2 (2.8%), copper-binding protein in 25 (35.7%), greater amount of hemosiderin in 9 (12.8%) cases. Thorotrast was not detected. One or more markers were seen in 38 (54.3%) cases, most frequently in association with liver cell dysplasia and alcoholism. The presence of hepatitis B surface antigen in livers with dysplastic foci was highly significant as compared to organs showing no dysplasia. Only the mentioned antigen and the alpha-1-antitrypsin globules were found to indicate the etiology of the underlying liver lesion. The value of the other markers was found inconsistent in etiological diagnosis.
D000293:Adolescent; D000368:Aged; D000437:Alcoholism / Q000150:complications; D001344:Autopsy; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000473:pathology; D002570:Ceruloplasmin / Q000032:analysis; D002648:Child; D005260:Female; D006485:Hemosiderin / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000515:alpha 1-Antitrypsin / Q000032:analysis
D006514:Hepatitis B Surface Antigens; D000515:alpha 1-Antitrypsin; D006485:Hemosiderin; D002570:Ceruloplasmin