Radiation-induced malignant fibrous histiocytoma: a report of five cases including two occurring post whole brain irradiation.
Five patients who were successfully treated with external radiation therapy for a variety of histologically unrelated tumors subsequently developed malignant fibrous histiocytoma (MFH) within the irradiated field. It is suggested that therapeutic irradiation was a causative factor in the development of these tumors with latent periods ranging between 3 and 17 years. A review of the pertinent literature is presented. It is apparent that postradiation MFH is being recognized with increasing frequency and at an earlier age than when it appears de novo.
D000328:Adult; D000368:Aged; D001921:Brain / Q000528:radiation effects*; D005260:Female; D005910:Glioma / Q000532:radiotherapy; D018219:Histiocytoma, Benign Fibrous / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D014565:Urogenital Neoplasms / Q000532:radiotherapy