title: A 1100-bp sequence of mitochondrial DNA is involved in senescence process in Podospora: study of senescent and mutant cultures.
abstract: In Podospora, senescence is assumed to be caused by the amplification of short sequences of the mitochondrial genome (sen-DNAs). We have characterized a 1100-bp-long mitochondrial DNA sequence which could be directly involved in the phenomenon. Indeed, by hybridization experiments, we show that this sequence is both present in all the sen-DNA molecules which originate from the beta region of the mitochondrial chromosome and rearranged in the mitochondrial genome of two mitochondrial mutants selected as resistant to senescence.
mesh_terms: D001203:Ascomycota / Q000235:genetics* / Q000254:growth & development; D001483:Base Sequence; D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes; D004272:DNA, Mitochondrial / Q000235:genetics*; D005784:Gene Amplification; D005800:Genes, Fungal; D009154:Mutation; D009693:Nucleic Acid Hybridization; D013997:Time Factors
chemical_list: D004272:DNA, Mitochondrial; D004262:DNA Restriction Enzymes