title: Signet-ring-cell thyroid tumors. Follicle cell tumors with arrest of folliculogenesis.
abstract: This study describes three carcinomas and three benign follicle-cell lesions that consisted of vacuolated thyrocytes. In five of these tumors the neoplastic cells, wholly or in part, had the same unique signet-ring-cell feature as recently described for a mucinous microfollicular thyroid adenoma case. On electron microscopy, however, intracellular lumina that were bordered by microvilli were shown. Serial sections of the epon-embedded material and the results of mucin stains and thyroglobulin-immunostaining excluded primary mucin-producing tumors of the thyroid and in each of our six thyroid lesions gave evidence of an arrest of folliculogenesis.
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002291:Carcinoma, Papillary / Q000473:pathology; D005260:Female; D006652:Histological Techniques; D006801:Humans; D008297:Male; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology*