Effect of aging on in vitro dopamine biosynthesis in the median eminence of rat hypothalamic slices.
The rates of basal and cyclic AMP-dependent DOPA accumulation in the median eminence of hypothalamic slices were not different between ovariectomized young and aged rats. However, the rate of Ca2+-dependent, depolarization-induced DOPA accumulation was smaller in aged rats, suggesting that the Ca2+ system in the regulation of dopamine biosynthesis in tuberoinfundibular dopaminergic neurons is altered by aging.
D000375:Aging; D000818:Animals; D002118:Calcium / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D004295:Dihydroxyphenylalanine / Q000032:analysis; D004298:Dopamine / Q000096:biosynthesis*; D005260:Female; D066298:In Vitro Techniques; D008473:Median Eminence / Q000378:metabolism*; D008564:Membrane Potentials; D051381:Rats; D011919:Rats, Inbred Strains
D004295:Dihydroxyphenylalanine; D000242:Cyclic AMP; D002118:Calcium; D004298:Dopamine