Effect of dichloroacetate in the treatment of anoxic lactic acidosis in dogs.
Lactic acidosis is seen frequently after severe anoxia and circulatory failure. Because dichloroacetate (DCA) has been shown to be effective in the treatment of lactic acidosis, we studied its effect on lactate levels and pH in arterial and sagittal sinus blood specimens in a pediatric canine model of anoxic cardiac arrest followed by CPR. Lactate levels rose steadily in all puppies receiving DCA alone (group 1), DCA plus bicarbonate (group 2), bicarbonate alone (group 3), or neither drug (group 4). Arterial and sagittal-sinus lactate levels were in the range of 2 mmol/L during the baseline period, 6 mmol/L after anoxic arrest, and 10 mmol/L after 20 min of CPR. Bicarbonate, but not DCA, significantly raised arterial pH. Neither drug reversed the progression of acidosis in the sagittal sinus; mean pH ranged from 6.85 to 6.92 among the four groups after 20 min of CPR. We speculate that DCA did not decrease lactate levels or raise the pH in either the peripheral circulation or the CNS (sagittal sinus) because of poor perfusion achieved during closed-chest cardiac compression.
D000085:Acetates / Q000627:therapeutic use*; D000140:Acidosis, Lactic / Q000150:complications / Q000188:drug therapy*; D000818:Animals; D001639:Bicarbonates / Q000627:therapeutic use; D002245:Carbon Dioxide / Q000097:blood; D003999:Dichloroacetic Acid / Q000627:therapeutic use*; D004285:Dogs; D006323:Heart Arrest / Q000150:complications; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid; D008954:Models, Biological; D010100:Oxygen / Q000097:blood; D012151:Resuscitation; D012964:Sodium / Q000627:therapeutic use; D017693:Sodium Bicarbonate
D000085:Acetates; D001639:Bicarbonates; D007773:Lactates; D002245:Carbon Dioxide; D019344:Lactic Acid; D017693:Sodium Bicarbonate; D003999:Dichloroacetic Acid; D012964:Sodium; D010100:Oxygen