The role of Na-hylan in reducing postsurgical tendon adhesions.
Na-hylan, a chemically modified sodium hyaluronate jelly, was studied mechanically and histologically as a surgical device to diminish tendon adhesion in the rabbit long toe extensor three weeks after surgical abrasion. This device was found to be highly effective (55% of treated tendons formed no adhesions compared to 5% of controls, and only 18% formed severe adhesions compared to 62% of controls). No gross or histologic evidence of significant acute or chronic inflammatory reaction to the Na-hylan was found.
D000818:Animals; D005069:Evaluation Studies as Topic; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D013710:Tendons / Q000033:anatomy & histology / Q000502:physiology / Q000601:surgery*; D000267:Tissue Adhesions / Q000517:prevention & control
C049816:hylan; D006820:Hyaluronic Acid