Synergistic inhibition of human T-cell lymphotropic virus type III replication in vitro by phosphonoformate and recombinant alpha-A interferon.
Phosphonoformate and recombinant alpha-A interferon synergistically inhibited the replication of human T-cell lymphotropic virus type III in cultured peripheral blood lymphocytes. T-cell proliferative capability was maintained by this combination, and toxicity was minimal.
D002478:Cells, Cultured; D017977:Deltaretrovirus / Q000187:drug effects*; D004357:Drug Synergism; D017245:Foscarnet; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D008214:Lymphocytes / Q000382:microbiology; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*
D007370:Interferon Type I; D009943:Organophosphorus Compounds; D011994:Recombinant Proteins; D017245:Foscarnet; D010746:Phosphonoacetic Acid