title: Curare can reverse the failure in muscle contraction caused by an AChE inhibitor.
abstract: Diisopropyl fluorophosphate, which is an organophosphate inhibitor of acetylcholinesterase, caused an irreversible block of neuromuscular transmission in the rat diaphragm preparation. This block could be reversed by the addition of a competitive antagonist of acetylcholine such as D-tubocurarine.
mesh_terms: D000818:Animals; D007531:Isoflurophate / Q000037:antagonists & inhibitors*; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects*; D014403:Tubocurarine / Q000494:pharmacology*
chemical_list: D007531:Isoflurophate; D014403:Tubocurarine