Deoxythymidine kinase, a possible marker for monitoring activity of cytomegalovirus infection after renal transplantation.
Measurement of deoxythymidine kinase activity (S-TK) in serum is used as a marker for cytomegalovirus (CMV) infection following transplant surgery. A case is presented where a kidney transplant patient suffered a fatal CMV infection. The new antiviral drug Foscarnet was used to treat the infection. Retrospective analysis of S-TK showed a good correlation with the course of the disease, its treatment, recurrence and final outcome.
D000998:Antiviral Agents / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000188:drug therapy / Q000201:enzymology*; D017245:Foscarnet; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D011183:Postoperative Complications; D012189:Retrospective Studies; D013937:Thymidine Kinase / Q000097:blood*
D000998:Antiviral Agents; D017245:Foscarnet; D013937:Thymidine Kinase; D010746:Phosphonoacetic Acid