[Effect of fusaric acid on phosphoinositide metabolism in the erythrocyte membranes of rats with spontaneous hypertension].
2- and 4-month-old male spontaneously hypertensive rats (SHR) were injected fusaric acid at a dose of 50 mg/kg body weight. Fusaric acid increased diphosphoinositide (DPI) and triphosphoinositide (TPI) levels in erythrocyte membranes of 4-month-old SHR by 41% and 20%, respectively. 32P incorporation into TPI decreased by 24% in 2- and by 20% in 4-month-old SHR. Phosphatidylinositol metabolism remained unchanged. The results also suggest that fusaric acid normalized DPI and TPI metabolism in erythrocyte membranes of SHR.
D000818:Animals; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D005669:Fusaric Acid / Q000494:pharmacology*; D006973:Hypertension / Q000097:blood*; D008297:Male; D010716:Phosphatidylinositols / Q000097:blood*; D010848:Picolinic Acids / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR
D010716:Phosphatidylinositols; D010848:Picolinic Acids; D005669:Fusaric Acid
Vliianie fuzarovoĭ kisloty na metabolizm fosfoinozitidov membran éritrotsitov krys so spontannoĭ gipertonieĭ.