A brain phosphatase with specificity for microtubule-associated protein-2.
A protein phosphatase has been isolated from brain using, as assay substrate throughout the purification, microtubule-associated protein-2 which had been phospho-labeled by its associated kinase. In contrast to other protein phosphatases, this phosphatase can effectively release phosphate from both the microtubule-binding and projection domains of microtubule-associated-protein-2. This enzyme appears to be a distinct, specific phosphatase that does not readily fit into previous classification schemes and is possibly the enzyme responsible for dephosphorylating microtubule-associated protein-2 in vivo.
D000227:Adenine Nucleotides / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002417:Cattle; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D007700:Kinetics; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D010749:Phosphoprotein Phosphatases / Q000302:isolation & purification / Q000378:metabolism*; D012492:Salts; D013379:Substrate Specificity; D014018:Tissue Distribution
D000227:Adenine Nucleotides; D008869:Microtubule-Associated Proteins; D012492:Salts; C049301:microtubule-associated protein-2 phosphatase; D010749:Phosphoprotein Phosphatases