title: Age related changes of glucagon binding and activity in isolated rat hepatocytes.
abstract: Hepatocytes isolated from young and old rats were compared for glucagon binding and its biological effect. Liver cells from young rats showed a receptor binding of the hormone significantly higher than cells from old rats. Such a behaviour was paralleled by the activity of the hormone. In fact, the glucagon-dependent stimulation of adenylate cyclase in the hepatocytes from the former group of animals was twice as high as in the latter.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000375:Aging; D000818:Animals; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D005934:Glucagon / Q000378:metabolism* / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011964:Receptors, Gastrointestinal Hormone / Q000378:metabolism*; D018027:Receptors, Glucagon
chemical_list: D011964:Receptors, Gastrointestinal Hormone; D018027:Receptors, Glucagon; D005934:Glucagon; D000242:Cyclic AMP; D000262:Adenylyl Cyclases