Acute pure sensory paraneoplastic neuropathy with perivascular endoneurial inflammation: ultrastructural study of capillary walls.
We studied a patient with epidermoid carcinoma of the lung (treated surgically 1 year earlier) and an acute symmetric pure sensory neuropathy that regressed almost completely within 1 month. Superficial peroneal nerve biopsy 15 days after onset showed evidence of demyelination with perivascular endoneurial inflammation. On ultrastructural examination, lymphocytes were seen passing through endothelial cells of endoneurial capillaries.
D002196:Capillaries / Q000648:ultrastructure*; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008875:Middle Aged; D009443:Neuritis / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000473:pathology*; D010523:Peripheral Nervous System Diseases / Q000473:pathology*; D012677:Sensation / Q000502:physiology*