[Synthesis of anomeric 5-trimethylgermyl-2'-deoxyuridines and study of their antiviral and cytotoxic properties].
Glycosylation of silylated 5-trimethylgermyluracil with 2-deoxy-3,5-di-O-p-toluyl-alpha-D-ribofuranosylchloride in dichloroethane in the presence of SnCl4 and subsequent deacylation led to anomeric 5-trimethylgermyl-2'-deoxyuridines. The alpha-nucleoside inhibits HSV-1 replication in vitro, blocks 2'-deoxyuridine incorporation into DNA of hepatoma 22A cells and incorporation of thymidine into DNA of cancer ovarian cells as well. Treatment with 125 mg/kg X 5 days of alpha-nucleoside fails to increase the life-span of mice with leukemia P388.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D002645:Chickens; D004273:DNA, Neoplasm / Q000096:biosynthesis; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005347:Fibroblasts / Q000382:microbiology; D005857:Germanium / Q000494:pharmacology; D008114:Liver Neoplasms, Experimental / Q000378:metabolism; D051381:Rats; D018139:Simplexvirus / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004273:DNA, Neoplasm; D005857:Germanium; D003857:Deoxyuridine
Sintez anomernykh 5-trimetilgermil-2'-dezoksiuridinov i izuchenie ikh protivovirusnykh i tsitotoksicheskikh svoĭstv.