Effect of bicuculline on sexual activity in castrated male rats.
The GABA antagonist (+) bicuculline methiodide (30 ng/cannula) was injected in the medial preoptic-anterior hypothalamic area of castrated rats treated with subthreshold dosages of testosterone propionate (150 micrograms/kg/day). The treatment resulted in a facilitation of sexual activity suggesting a role of GABA as a neurotransmitter in neural processes determining sexual arousal.
D000818:Animals; D001640:Bicuculline / Q000008:administration & dosage*; D004357:Drug Synergism; D007032:Hypothalamus, Anterior / Q000187:drug effects*; D008297:Male; D009919:Orchiectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical; D009435:Synaptic Transmission; D013739:Testosterone / Q000008:administration & dosage*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D013739:Testosterone; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline