Haemopoietic growth factors: structure and receptor interactions.
The proteins which regulate the production of blood cells appear to have overlapping functions. There are several forms of the haemopoietic growth factors (HGFs). Although a few have been purified, the functions of the different growth factors have not yet been clarified. The amino acid sequence of murine granulocyte-macrophage colonystimulating factor (GM-CSF) has been determined from a cDNA clone and several molecular forms of the molecule have been purified. Although there is no extensive homology with other haemopoietic growth factors, the mRNA for GM-CSF suggests two possible functions for this molecule. Radioiodination of GM-CSF to high specific activity has permitted the detection of two classes of specific GM-CSF receptors on myeloid cells. Although the different haemopoietic growth factors do not compete directly for binding to their specific receptors, GM-CSF and interleukin 3 (IL-3) can modulate the availability of other HGF receptors.
D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation; D003115:Colony-Stimulating Factors / Q000502:physiology*; D006133:Growth Substances / Q000032:analysis / Q000302:isolation & purification / Q000502:physiology*; D016298:Hematopoietic Cell Growth Factors; D006801:Humans; D007377:Interleukin-3; D007938:Leukemia / Q000473:pathology; D008222:Lymphokines / Q000502:physiology*; D051379:Mice; D011956:Receptors, Cell Surface / Q000032:analysis; D016184:Receptors, Colony-Stimulating Factor; D011971:Receptors, Immunologic / Q000032:analysis; D015375:Receptors, Interleukin-2; D016185:Receptors, Interleukin-3
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D016298:Hematopoietic Cell Growth Factors; D007377:Interleukin-3; D008222:Lymphokines; D011956:Receptors, Cell Surface; D016184:Receptors, Colony-Stimulating Factor; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D016185:Receptors, Interleukin-3