Protection against Brucella abortus in mice with O-polysaccharide-specific monoclonal antibodies.
Mice injected with either of two monoclonal antibodies specific for the O polysaccharide of Brucella abortus prior to challenge infection had viable counts in spleens and livers significantly below those in control groups 1 and 4 weeks later. Two monoclonal antibodies specific for the porin of B. abortus failed to confer protection.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D002003:Brucella abortus / Q000276:immunology*; D002006:Brucellosis / Q000276:immunology / Q000517:prevention & control*; D007116:Immunization, Passive; D008099:Liver / Q000276:immunology; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D018272:Porins; D013154:Spleen / Q000276:immunology
D000911:Antibodies, Monoclonal; D001425:Bacterial Outer Membrane Proteins; D011135:Polysaccharides, Bacterial; D018272:Porins