Simplified detection system for neuroreceptor studies in the human brain.
A simple, inexpensive dual-detector system has been developed for measurement of positronemitting receptor-binding drugs in the human brain. This high efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing for multiple studies without an excessive radiation dose. Measurement of the binding of [11C]carfentanil, a high affinity synthetic opiate, to opiate receptors in the presence and in the absence of a competitive opiate antagonist indicates the potential utility of this system for estimating different degrees of receptor occupation in the human brain.
D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D002138:Calibration; D002250:Carbon Radioisotopes; D004583:Electrons; D004867:Equipment Design; D005283:Fentanyl / Q000031:analogs & derivatives; D006801:Humans; D009270:Naloxone / Q000494:pharmacology; D011869:Radioligand Assay / Q000295:instrumentation*; D011957:Receptors, Opioid / Q000032:analysis* / Q000187:drug effects; D012588:Scintillation Counting / Q000295:instrumentation*
D002250:Carbon Radioisotopes; D011957:Receptors, Opioid; D009270:Naloxone; C017114:carfentanil; D005283:Fentanyl