A study of the mediator spectrum of delta-9 tetrahydrocanabinol effects on cerebral bioelectric activity.
Defense conditioning in cats with simultaneous recording of bioelectric activity was used to show that serotonin-negative and dopamine-positive substances normalize delta-9 THC-elicited dissimilarity of amplitudinal and temporal parameters of evoked potentials in visual associative and somatosensoric zones II of the cerebral cortex. It was also found that serotoninergic substances affect both primary and secondary waves of evoked potentials while dopaminergic substances influence only late waves.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D013759:Dronabinol / Q000494:pharmacology*; D004569:Electroencephalography; D005074:Evoked Potentials, Visual / Q000187:drug effects; D010134:Fenclonine / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology; D008781:Methyltyrosines / Q000494:pharmacology; D008784:Methysergide / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D013003:Somatosensory Cortex / Q000187:drug effects; D013566:Sympathomimetics / Q000494:pharmacology; D014793:Visual Cortex / Q000187:drug effects
D008781:Methyltyrosines; D013566:Sympathomimetics; C032745:methyl-3-tyrosine; D012701:Serotonin; D007980:Levodopa; D013759:Dronabinol; D001058:Apomorphine; D010134:Fenclonine; D004298:Dopamine; D009638:Norepinephrine; D008784:Methysergide