[Comparative study of the action of Vibrio cholerae enterotoxin, thermolabile Escherichia coli toxin and a Salmonella typhimurium filtrate on the small intestine of laboratory animals].
The results of the comparative study of the effects produced by V. cholerae enterotoxin E. coli thermolabile toxin (TL-toxin) and S. typhimurum 415 filtrate on the loops of the small intestine of rabbits and C57BL/6 mice are presented. The results obtained in mice were considerably more uniform than those obtained in rabbits. For the first time the dose-effect curve for V. cholerae enterotoxin and TL-toxin, obtained on both animal species, was found to be bell-shaped. The concentration relationship for dibutyryl-cAMP proved to be similar in character. The authors suggest that these effects are based on the specific relationship between the cellular processes, controlling the transport of electrolytes and water, and the level of cAMP.
D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity*; D003994:Bucladesine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004768:Enterotoxins / Q000633:toxicity*; D004926:Escherichia coli; D005260:Female; D007421:Intestine, Small / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011817:Rabbits; D012486:Salmonella typhimurium; D013045:Species Specificity; D013806:Theophylline / Q000494:pharmacology; D014734:Vibrio cholerae
D001427:Bacterial Toxins; D004768:Enterotoxins; C037420:stN protein, Vibrio cholerae; D003994:Bucladesine; D013806:Theophylline
Sravnitel'noe izuchenie deĭstviia énterotoksina Vibrio cholerae, termolabil'nogo toksina Escherichia coli i fil'trata Salmonella typhimurium na tonkuiu kishku laboratornykh zhivotnykh.