The effect of alpha, beta-methylene ATP on the depolarization evoked by noradrenaline (gamma-adrenoceptor response) and ATP in the immature rat basilar artery.
Depolarizations evoked by noradrenaline that were resistant to alpha- and beta-adrenoceptor antagonists were recorded in the rat basilar artery. These gamma-adrenoceptor-mediated responses and the depolarizations to adenosine triphosphate (ATP) were blocked by pretreatment of the tissue with alpha, beta-methylene ATP. These data are discussed with respect to the selectivity of alpha, beta-methylene ATP.
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001488:Basilar Artery / Q000187:drug effects; D004492:Edetic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009467:Neuromuscular Depolarizing Agents; D009638:Norepinephrine / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011983:Receptors, Purinergic
D009467:Neuromuscular Depolarizing Agents; D011956:Receptors, Cell Surface; D011983:Receptors, Purinergic; D000255:Adenosine Triphosphate; D004492:Edetic Acid; D011433:Propranolol; C002630:alpha,beta-methyleneadenosine 5'-triphosphate; D001205:Ascorbic Acid; D009638:Norepinephrine; D010646:Phentolamine