Alpha 1-adrenergic activation of brown adipocytes leads to an increased formation of inositol polyphosphates.
alpha 1-Adrenergic activation of isolated brown adipocytes causes a rapid mobilization of intracellular Ca2+. The cells also respond with an increased turnover of inositol lipids. The present work demonstrates that alpha 1-adrenergic stimulation of brown adipocytes results in phospholipase C-mediated breakdown of phosphatidylinositol bisphosphate to form inositol trisphosphate. The rate of appearance of inositol trisphosphate is sufficiently rapid for it to mediate or contribute to Ca2+ mobilization in these cells.
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000502:physiology; D006224:Cricetinae; D007295:Inositol Phosphates / Q000096:biosynthesis*; D008094:Lithium / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000378:metabolism; D011224:Prazosin / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D013403:Sugar Phosphates / Q000096:biosynthesis*; D015016:Yohimbine / Q000494:pharmacology
D007295:Inositol Phosphates; D010716:Phosphatidylinositols; D011942:Receptors, Adrenergic, alpha; D013403:Sugar Phosphates; D015016:Yohimbine; D008094:Lithium; D002118:Calcium; D009638:Norepinephrine; D011224:Prazosin