Detection of a polyoma virus-induced tumor-associated membrane antigen in mouse cells by the macrophage migration inhibition test.
Soluble membrane fractions derived from polyoma tumor cells trigger lymphocytes, derived from polyoma-immunized animals, but not from nonimmunized controls, to release the lymphokine, macrophage migration-inhibitory factor. The reaction can be blocked by sera from polyoma-bearing animals. Absorption of these sera with polyoma cells, but not with nonpolyoma cell lines, abrogates this activity. These findings suggest that there is a polyoma virus-induced membrane component that can induce polyoma-specific macrophage migration inhibition.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000952:Antigens, Polyomavirus Transforming; D000954:Antigens, Surface / Q000032:analysis*; D000957:Antigens, Viral, Tumor / Q000032:analysis*; D002464:Cell Migration Inhibition; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D009856:Oncogene Proteins, Viral / Q000032:analysis; D011120:Polyomavirus / Q000276:immunology*; D051381:Rats; D014412:Tumor Virus Infections / Q000276:immunology
D000911:Antibodies, Monoclonal; D000952:Antigens, Polyomavirus Transforming; D000954:Antigens, Surface; D000957:Antigens, Viral, Tumor; D009856:Oncogene Proteins, Viral