Correlation between the presence of antibodies to the Epstein-Barr virus nuclear antigen type 2 and antibodies to the rheumatoid arthritis nuclear antigen in patients with rheumatoid arthritis.
The incidence of antibodies to Epstein-Barr nuclear antigen type 2 (EBNA-2) was determined in sera from rheumatoid arthritis (RA) patients and control subjects, by protein immunoblotting. Sixty-eight percent of the RA patients and 48% of the controls possessed anti-EBNA-2 antibodies. The titer of anti-rheumatoid arthritis nuclear antigen (RANA) in RA patient sera showed a stronger correlation with serum reactions to EBNA-2 than with reactions to EBNA-1. Our results indicate that the presence of EBNA-2 may make a major contribution to the RANA reaction.
D000906:Antibodies / Q000276:immunology*; D000974:Antibodies, Antinuclear / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology*; D000941:Antigens / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D019309:Epstein-Barr Virus Nuclear Antigens; D005455:Fluorescent Antibody Technique; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007244:Infectious Mononucleosis / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D009303:Nasopharyngeal Neoplasms / Q000276:immunology
D000906:Antibodies; D000974:Antibodies, Antinuclear; D000914:Antibodies, Viral; D000941:Antigens; D000956:Antigens, Viral; D001324:Autoantigens; D019309:Epstein-Barr Virus Nuclear Antigens; C030352:rheumatoid arthritis nuclear antigen