A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients.
A newly identified protein from HTLV-III/LAV, the virus implicated as the etiologic agent of the acquired immune deficiency syndrome, was studied. This protein, which has a molecular weight of 27,000 (p27), was shown by amino acid sequencing to have a coding origin 3' to the env gene on the HTLV-III genome. The presence of antibodies to p27 in virus-exposed individuals indicated that this gene is functional in the natural host.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000382:microbiology; D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000917:Antibody Formation; D000956:Antigens, Viral / Q000276:immunology*; D017977:Deltaretrovirus / Q000235:genetics / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D000882:Haplorhini / Q000382:microbiology; D006801:Humans; D008297:Male; D008970:Molecular Weight; D012091:Repetitive Sequences, Nucleic Acid
D000914:Antibodies, Viral; D000956:Antigens, Viral