Imidazolyl derivatives of enalapril as potential angiotensin converting enzyme inhibitors.
The synthesis of a few derivatives of the angiotensin converting enzyme inhibitor enalapril is described. In these molecules the chelating carbethoxy group is substituted with an imidazolyl one. The compounds were tested both in vitro and in vivo. None of them showed in vivo activity but only a marginal in vitro inhibitory activity.
D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004656:Enalapril / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D007093:Imidazoles; D004656:Enalapril; D002216:Captopril