Collagen prolyl hydroxylase inhibitor and reduced collagen formation in cotton pellet-induced granuloma and skin wound healing in rats.
P-1894B an inhibitor of collagen prolyl hydroxylase was applied topically to cotton pellet-induced granuloma and to skin lesions in rats. The total hydroxyproline content of the granulomata was significantly reduced by this agent. It also reduced the hydroxyproline content in the tissues surrounding skin lesions during the healing process, with delayed diminution in lesion size. These results suggest that collagen prolyl hydroxylase inhibitor P-1894B may be a suitable agent for topical treatment of hypertrophic scar tissue or keloid.
D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology*; D003094:Collagen / Q000096:biosynthesis*; D005260:Female; D006099:Granuloma / Q000378:metabolism* / Q000473:pathology; D006909:Hydroxyproline / Q000032:analysis; D011393:Procollagen-Proline Dioxygenase / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D012871:Skin Diseases / Q000378:metabolism* / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
D000880:Anthraquinones; C032958:vineomycin A1; D003094:Collagen; D011393:Procollagen-Proline Dioxygenase; D006909:Hydroxyproline