Phencyclidine-induced stereotyped behaviors after injection of morphine and N-allylnormetazocine (SKF 10,047) in rats.
We investigated the effects of N-allylnormetazocine (SKF 10,047) and morphine on the stereotyped behaviors induced by the intraperitoneal injection of phencyclidine (PCP). PCP-induced turning and backpedalling were significantly potentiated by pretreatment with SKF 10,047 (10 mg/kg) but sniffing and head weaving were not. On the other hand, pretreatment with morphine dose-dependently attenuated PCP-induced sniffing and head weaving, but not turning and backpedalling. These results suggest that PCP-induced stereotypy may be mediated by not only a sigma opioid receptor but also some other receptors. In addition, each component of PCP-induced stereotypy may be controlled by different opioid systems and/or neuronal systems.
D000818:Animals; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D010620:Phenazocine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects; D017480:Receptors, sigma; D013239:Stereotyped Behavior / Q000187:drug effects*
D011957:Receptors, Opioid; D017480:Receptors, sigma; C012134:SK&F 10047; D009020:Morphine; D010620:Phenazocine; D010622:Phencyclidine