Histological evidence for rescue of radiation dermatitis in an ultraviolet model system.
Rescue of acute radiation dermatitis has already been shown feasible with cytochrome c(Sci. Rep. Res. Inst. Tohoku Univ.-C 29: 1, 1982). Interest in the probable reduction of inflammatory sequelae led to histological studies in an ultraviolet model system in the rabbit. The relative dermal thickness in the field of ultraviolet irradiation was 1.70 +/- 0.30 (5) in the untreated control and 1.31 +/- 0.07 (5) in the cytochrome c group respectively (p less than 0.05). Usefulness of the principle cannot be overemphasized in the strategies of radiotherapy, and in the treatment and/or prevention of actinic radiation dermatitis.
D000818:Animals; D003574:Cytochrome c Group / Q000627:therapeutic use*; D003872:Dermatitis / Q000473:pathology / Q000517:prevention & control*; D011817:Rabbits; D011832:Radiation Injuries / Q000473:pathology / Q000517:prevention & control*; D014466:Ultraviolet Rays / Q000009:adverse effects*
D003574:Cytochrome c Group