title: Detection of cytomegalovirus antigen and antibodies in the urine of small infants and children.
abstract: The diagnostic efficacy of an enzyme immune assay to detect cytomegalovirus (CMV) antigen in the urine of infected infants and children was determined, and the effect that CMV-specific antibodies present in the urine have on the sensitivity of the test was ascertained. The antigen was detected in 84.4% of the CMV-culture-positive samples, while CMV-specific IgA was detected in 24% of CMV-culture-positive specimens. The absence of CMV-specific IgA correlated with detection of CMV antigen in the CMV-culture-positive urine specimens (p less than 0.05).
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology / Q000652:urine*; D000936:Antigen-Antibody Complex / Q000652:urine; D000956:Antigens, Viral / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology / Q000652:urine; D003588:Cytopathogenic Effect, Viral; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000652:urine; D007071:Immunoglobulin A, Secretory / Q000652:urine; D007074:Immunoglobulin G / Q000652:urine; D007223:Infant; D007231:Infant, Newborn; D008297:Male
chemical_list: D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G