Antibodies to the human T-cell lymphoma/leukemia virus type I in Dutch haemophiliacs.
95 Dutch haemophiliacs were tested for antibodies to membrane antigens on cells infected with human T-cell leukemia virus type I (HTLV-I-MA) by indirect immunofluorescence and to purified HTLV-I by enzyme-linked immunosorbent assay. Antibodies to HTLV-I-MA were present in 8 of 95 (8%) haemophiliacs, but only 3 (3%) had antibodies to purified HTLV-I. No clinical disease was related to HTLV-I seropositivity. The importance of iatrogenic HTLV-I transmission to haemophiliacs is discussed.
D000914:Antibodies, Viral / Q000032:analysis*; D001803:Blood Transfusion; D017977:Deltaretrovirus / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006467:Hemophilia A / Q000276:immunology* / Q000628:therapy; D006801:Humans; D009426:Netherlands
D000914:Antibodies, Viral