title: Radiobrominated spiroperidol for the study of dopamine D2 receptors.
abstract: Some neuropsychiatric disorders have been suggested to be related to the CNS dopaminergic system. In order to probe this neurotransmitter system, radiobrominated spiroperidol, a potent dopamine (DA) D2-receptor antagonist, was developed. This review deals with the routine synthesis of [75, 76, or 77Br]-p-bromospiroperidol (BrSP), its validation as a radiopharmaceutical directed to DA D2 receptors, and the imaging studies which have been done using this radioligand with either single photon tomography (SPECT) or positron tomography (PET). [*Br]BrSP will be compared to other D2 ligands currently available. The present state and future direction of DA receptor research, in particular, the quantitative aspects, will be discussed.
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging; D001966:Bromine; D006801:Humans; D011868:Radioisotopes; D011869:Radioligand Assay; D011954:Receptors, Dopamine / Q000032:analysis*; D013134:Spiperone / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
chemical_list: D011868:Radioisotopes; D011954:Receptors, Dopamine; D013134:Spiperone; C026326:4-bromospiperone; D001966:Bromine