[Effect of 4-aminopyridine on the development of experimental botulism].
The studies of survival and the life span of mice and the toxin in LD50 have shown that 4-aminopyridine (4-AP) at doses of 1, 2 and 5 mg/kg has a therapeutic effect on type C botulinic intoxication. Maximum protective effect is observed when 4-AP at a dose of 2 mg/kg is injected twice daily. Therefore, 4-AP, enhancing the transmitter release into cholinergic synapses, weakens the toxic effect of botulinic toxin.
D015761:4-Aminopyridine; D000631:Aminopyridines / Q000627:therapeutic use*; D000818:Animals; D001905:Botulinum Toxins / Q000037:antagonists & inhibitors; D001906:Botulism / Q000517:prevention & control*; D008297:Male; D051379:Mice; D051381:Rats
D000631:Aminopyridines; D015761:4-Aminopyridine; D001905:Botulinum Toxins
Vliianie 4-aminopiridina na razvitie éksperimental'noĭ botulinicheskoĭ intoksikatsii.