Kinetic studies on the diaqua form of cis-platin and various nucleobases.
Kinetic studies on cis-[Pt(NH3)2(OH2)2]2+ and various nucleobases show that this ion reacts more quickly with guanosine than with adenosine, cytidine, and thymidine, and that a monophosphoric acid unit considerably enhances the rate of reaction of guanosine; the kinetic preference of 5'-GMP over 5'-AMP may point to a greater thermodynamic selectivity.
D000249:Adenosine Monophosphate; D002945:Cisplatin; D006157:Guanosine Monophosphate; D007700:Kinetics; D012263:Ribonucleosides; D013329:Structure-Activity Relationship; D013816:Thermodynamics
D012263:Ribonucleosides; D000249:Adenosine Monophosphate; D006157:Guanosine Monophosphate; D002945:Cisplatin