Influence of estrogen levels on anticholinergic activity of tricyclic antidepressives.
Anticholinergic activity of a number of tricyclic antidepressives and nomifensine was demonstrated and their order of affinity for the cholinergic receptors of rat jejunum was determined. The influence of ethinyl estradiol and a conjugated estrogen product, Premarin on the binding of several tricyclic antidepressives to the hepatic mixed function oxidase system was investigated. The influence of these steroids on the metabolism of the antidepressives was evaluated and ethinyl estradiol was shown to have a marked influence on the metabolism of the antidepressives studied, while conjugated estrogens were shown to have little effect.
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage* / Q000378:metabolism; D004347:Drug Interactions; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage*; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005260:Female; D007583:Jejunum / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009627:Nomifensine / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D011950:Receptors, Cholinergic / Q000378:metabolism*
D000929:Antidepressive Agents, Tricyclic; D004966:Estrogens, Conjugated (USP); D011950:Receptors, Cholinergic; D009627:Nomifensine; D004997:Ethinyl Estradiol; D006899:Mixed Function Oxygenases