title: Classification of Histoplasma capsulatum isolates by restriction fragment polymorphisms.
abstract: Twenty isolates of the dimorphic, pathogenic fungus Histoplasma capsulatum were divided into three classes based on comparisons of restriction enzyme digests of their mitochondrial DNA and rDNA. The majority of isolates, including most North American strains and the African H. capsulatum var. duboisii variants, belong to class 2. Isolates from Central America and South America make up class 3. The attenuated Downs strain is the only member of class 1.
mesh_terms: D000349:Africa; D000818:Animals; D002489:Central America; D004262:DNA Restriction Enzymes; D004271:DNA, Fungal / Q000032:analysis* / Q000235:genetics; D004272:DNA, Mitochondrial / Q000032:analysis; D006658:Histoplasma / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D009656:North America; D009693:Nucleic Acid Hybridization; D012331:RNA, Fungal / Q000235:genetics; D012335:RNA, Ribosomal / Q000235:genetics; D013020:South America
chemical_list: D004271:DNA, Fungal; D004272:DNA, Mitochondrial; D012331:RNA, Fungal; D012335:RNA, Ribosomal; D004262:DNA Restriction Enzymes