Evidence for the inductive effects of hexafluorobenzene on hepatic microsomal enzymes in the male rat.
Acute administration of hexafluorobenzene (HFB) (1200 mg/kg body wt i.p.), induced significant increases in male rat hepatic microsomal protein content (39% increase), microsomal cytochrome P-450 content (150% increase) and microsomal glucose-6-phosphatase activity (25% increase). The assays were carried out 24 h after treatment. Hexafluorobenzene also significantly shortened (by 22%) hexobarbitone-induced sleeping time.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects*; D005466:Fluorocarbons / Q000494:pharmacology*; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D006591:Hexobarbital / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects
D005466:Fluorocarbons; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; C003005:hexafluorobenzene; D005952:Glucose-6-Phosphatase