Identification of a 65 000 dalton virion envelope protein of human cytomegalovirus.
Human cytomegalovirus (CMV) specific monoclonal antibodies were shown to react with a broadly migrating 65-52 kDa virion envelope protein. These antibodies efficiently neutralized CMV in vitro (greater than 98% plaque reduction), suggesting that this envelope protein was an important target of neutralizing antibodies. This virion envelope protein was shown to be antigenically and electrophoretically distinct from a more abundant 68 kDa virion protein. The relationship between these virion proteins is discussed.
D000911:Antibodies, Monoclonal; D003587:Cytomegalovirus / Q000032:analysis*; D004591:Electrophoresis, Polyacrylamide Gel; D005455:Fluorescent Antibody Technique; D006801:Humans; D008970:Molecular Weight; D014759:Viral Envelope Proteins / Q000032:analysis*; D014771:Virion / Q000032:analysis*
D000911:Antibodies, Monoclonal; D014759:Viral Envelope Proteins