Metabolic and contractile changes in ischaemic rat hearts after isoproterenol administration: effect of reperfusion.
The effect of isoproterenol and of ischaemia followed by reperfusion was studied in isolated perfused rat heart. Whereas after an interval of 5 min of ischaemia the mechanical and biochemical responses to catecholamine were drastically reduced, reperfusion for 1 min normalized the cardiac reactivity. After prolonged ischaemia and reperfusion the hormone-induced rise in cyclic AMP and activation of cyclic AMP dependent protein kinase remains reduced. It is suggested that these changes might be of importance for cardiac protection during a transient ischaemic period.
D000818:Animals; D003326:Coronary Circulation; D003327:Coronary Disease / Q000503:physiopathology*; D000242:Cyclic AMP / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D006005:Phosphorylases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D051381:Rats
D000242:Cyclic AMP; D006005:Phosphorylases; D011494:Protein Kinases; D007545:Isoproterenol