[Presence of free retinol receptor (cRBP) and retinoic acid receptor (cRABP) in human skin tumors].
The concentrations of cellular retinoic acid binding protein (cRABP) and free cellular retinol binding protein (cRBP) were determined by ultracentrifugation in sucrose gradient in the cytosol of 41 human skin tumours (14 melanomas, 19 basal cell carcinomas, 8 squamous cell carcinomas). cRBP was found respectively in 36%, 42% and 37% of the studied samples. On the contrary, cRABP was more frequently found in carcinomas (89% in basal cell carcinomas and 100% in squamous cell carcinomas) than in melanomas (21%) (p less than 0.001). These results are discussed according to the different embryologic origin of carcinomas and melanomas. Furthermore, the better efficiency of synthetic retinoids in carcinomas than in melanomas should be explained by a different way of action in these 2 kinds of tumours.
D000328:Adult; D000368:Aged; D002280:Basal Cell Carcinoma / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000032:analysis; D002352:Carrier Proteins / Q000032:analysis*; D002499:Centrifugation, Density Gradient; D003600:Cytosol / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000032:analysis; D008875:Middle Aged; D018168:Receptors, Retinoic Acid; D012177:Retinol-Binding Proteins / Q000032:analysis*; D054840:Retinol-Binding Proteins, Cellular; D012878:Skin Neoplasms / Q000032:analysis*
D002352:Carrier Proteins; D018168:Receptors, Retinoic Acid; D012177:Retinol-Binding Proteins; D054840:Retinol-Binding Proteins, Cellular
Présence du récepteur libre au rétinol (cRBP) et du récepteur à l'acide rétinoïque (cRABP) dans les tumeurs cutanées humaines.