title: [Molecular mechanisms of substance dependence (regulatory-structural relations)].
abstract: The article is devoted to a potentially possible molecular mechanism of the formation of narcomanic states: euphoria, tolerance, dependence, abstinence and polynarcotism. The regulatory-structural system including a structural component (enzyme, receptor, membrane, etc.), regulatory components (genome, the system of hormonal synthesis, etc.), and transport components (blood, etc.) may be considered a simple and sufficient model of "elementary toxicomanic unit" in the animal body. Proceeding from the above characteristics of functioning of "the toxicomanic unit", the cause of toxicomanogenesis should be sought in the regulatory components, in their inertia. Toxicomanogenesis in biological system is the consequence of four superimposed phenomena: "narcotic" interaction, functional limitedness, regulatory inertia and psychic ability to project, with the regulatory inertia playing the determinant role.
mesh_terms: D000437:Alcoholism / Q000209:etiology; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D004798:Enzymes / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology; D005786:Gene Expression Regulation; D006801:Humans; D008962:Models, Theoretical; D009294:Narcotics / Q000378:metabolism / Q000494:pharmacology; D019966:Substance-Related Disorders / Q000209:etiology*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D004798:Enzymes; D009294:Narcotics; D000431:Ethanol
vernacular_title: Molekuliarnye mekhanizmy toksikomaniĭ (reguliatorno-strukturnye otnosheniia).