Interaction of adriamycin with cardiolipin-containing vesicles. Evidence of an embedded site for the dihydroanthraquinone moiety.
In the presence of cardiolipin-containing small unilamellar vesicles, the antitumor compound adriamycin loses its ability to catalyse the flow of electrons from NADH to molecular oxygen through NADH dehydrogenase. The data strongly suggest that in the presence of cardiolipin the dihydroanthraquinone moiety is embedded in the phospholipid bilayer and thus inaccessible to the enzyme.
D000880:Anthraquinones / Q000378:metabolism*; D002308:Cardiolipins / Q000494:pharmacology*; D004317:Doxorubicin / Q000378:metabolism* / Q000494:pharmacology; D004579:Electron Transport / Q000187:drug effects; D007700:Kinetics; D008081:Liposomes; D009243:NAD / Q000378:metabolism; D009245:NADH Dehydrogenase / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D013481:Superoxides / Q000378:metabolism
D000880:Anthraquinones; D002308:Cardiolipins; D008081:Liposomes; D009243:NAD; D013481:Superoxides; D004317:Doxorubicin; C047733:1,4-dihydroanthraquinone; D009245:NADH Dehydrogenase