Synthesis and radioprotective activity of new cysteamine and cystamine derivatives.
A variety of N-(aminoalkanoyl)-S-acylcysteamine and N,N'-bis(aminoalkanoyl)cystamine salt derivatives were synthesized. Toxicity and radioprotective activity (as the dose reduction factor DRF) were determined in vivo on mice and compared to WR 2721 and S-acetylcysteamine hydrochloride. One of the most interesting compounds of this series was N-glycyl-S-acetylcysteamine trifluoroacetate (16, I 102). Structure-activity relationships are discussed.
D004999:Amifostine / Q000494:pharmacology; D000818:Animals; D003538:Cystamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003543:Cysteamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D011837:Radiation-Protective Agents; D003543:Cysteamine; D004999:Amifostine; D003538:Cystamine