[Effect of etimizol on the neuromuscular synapse of the frog].
The effect of aethimizol, a substance activating the memory processes, was studied by intracellular recording at the frog cutaneous pectoris neuro-muscular preparation. Presynaptic action of aethimizol (0.5-2 mM) was found. This action consisted in the increase of miniature end-plate potentials (mEPP's) frequency and the modulation of quantal content of evoked end-plate potentials (EPP's) due to changes in binomial quantal release. parameters p and n. These effects depended on the initial level of quantal release. Aethimizol at the concentrations of 5-10 mM strongly decreased the amplitudes of mEPP's and EPP's while at the concentrations of 0.5-10 mM aethimizol increased the rising- and half-decay time of mEPP's and EPP's and half decay time of evoked end-plate currents presumably affecting the postsynaptic ionic channels properties. Aethimizol increased the time integral of EPP's. Effects of aethimizol are discussed in relation to its possible modes of action in the central neural system as a presumed unspecific connector.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D005042:Etimizol / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009045:Motor Endplate / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D011896:Rana temporaria; D009435:Synaptic Transmission / Q000187:drug effects*
D007093:Imidazoles; D000109:Acetylcholine; D005042:Etimizol
Deĭstvie étimizola na nervno-myshechnyĭ sinaps liagushki.