title: Long-term potentiation in guinea pig hippocampal slices monitored by optical recording of neuronal activity.
abstract: Pre- and postsynaptic potential changes evoked by stimulation of the Schaffer collateral-commissural input to CA1 pyramidal neurons were optically recorded in guinea pig hippocampal slices after staining the preparation with a suitable voltage-sensitive fluorescent dye. Brief tetanic stimulation induced long-term potentiation of synaptic transmission as monitored both optically and electrically. The results demonstrate that non-invasive optical techniques can be used to study long-term changes in spatial neuronal interactions, possibly involved in learning and other higher functions of the nervous system.
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology; D004594:Electrophysiology / Q000379:methods; D005071:Evoked Potentials; D006168:Guinea Pigs; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D008991:Monitoring, Physiologic / Q000379:methods; D009482:Neurophysiology / Q000379:methods; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
chemical_list: D002118:Calcium