Membrane antigen expression during hemopoietic differentiation.
The pattern of certain groups of antigens expressed on the surface of hemopoietic cells changes either during the course of differentiation from pluripotent stem cells to mature functional cells or as a function of the proliferative state of the cells. A map of these changes is emerging and is providing valuable information for selecting and purifying rare stem cells and for classifying the acute leukemias. This knowledge is also beginning to provide insights into physiological and pathological cellular interactions affecting the early stages of hemopoiesis, and is being exploited to remove T lymphocytes from allogeneic bone marrow grafts in order to prevent graft-vs.-host disease as well as leukemic cells from bone marrow before autologous reinfusion. In this article I will briefly review the cellular basis of hemopoiesis and then discuss the methods used to determine the presence of antigens on normal hemopoietic cells. I will then summarize the pattern of membrane antigens expressed during differentiation and conclude by discussing the biological and therapeutic implications.
D000818:Animals; D001457:Anion Exchange Protein 1, Erythrocyte / Q000276:immunology; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis / Q000276:immunology*; D001789:Blood Group Antigens / Q000276:immunology; D001798:Blood Proteins / Q000276:immunology; D016026:Bone Marrow Transplantation; D002450:Cell Communication; D002454:Cell Differentiation; D002462:Cell Membrane / Q000276:immunology*; D004920:Erythropoiesis; D006021:Glycophorins / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007158:Immunologic Techniques; D015470:Leukemia, Myeloid, Acute / Q000145:classification / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology; D033703:Nucleoside Transport Proteins; D011956:Receptors, Cell Surface / Q000276:immunology; D016184:Receptors, Colony-Stimulating Factor; D017467:Receptors, Erythropoietin; D011990:Receptors, Transferrin
D001457:Anion Exchange Protein 1, Erythrocyte; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D001789:Blood Group Antigens; D001798:Blood Proteins; D006021:Glycophorins; D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II; D008565:Membrane Proteins; D033703:Nucleoside Transport Proteins; D011956:Receptors, Cell Surface; D016184:Receptors, Colony-Stimulating Factor; D017467:Receptors, Erythropoietin; D011990:Receptors, Transferrin