title: [Gamma-aminobutyric acid receptors in the central nervous system of mammals].
abstract: The review describes properties of gamma-aminobutyric acid (GABA) receptors in the central nervous system of mammalians. Two pharmacologically different receptors--GABAA and GABAB--are involved into GABA-ergic inhibition. GABA receptors (bicuculline-sensitive) regulate chloride permeability of membranes and can be functionally enhanced by benzodiazepine and barbiturate. GABA receptors (bicuculline-insensitive) are suggested to regulate calcium permeability.
mesh_terms: D000818:Animals; D001001:Anura; D001341:Autonomic Nervous System / Q000032:analysis; D001463:Barbiturates / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002463:Cell Membrane Permeability; D002478:Cells, Cultured; D002490:Central Nervous System / Q000502:physiology*; D002712:Chlorides / Q000378:metabolism; D003292:Convulsants / Q000494:pharmacology; D006624:Hippocampus / Q000378:metabolism; D066298:In Vitro Techniques; D008968:Molecular Conformation; D009197:Myenteric Plexus / Q000502:physiology; D009433:Neural Inhibition; D051381:Rats; D011963:Receptors, GABA-A / Q000032:analysis / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission
chemical_list: D001463:Barbiturates; D002712:Chlorides; D003292:Convulsants; D011963:Receptors, GABA-A; C037480:picrotoxinin receptor; D001569:Benzodiazepines; D002118:Calcium; D001640:Bicuculline
vernacular_title: Retseptory gamma-aminomaslianoĭ kisloty v tsentral'noĭ nervnoĭ sisteme mlekopitaiushchikh.