Insulin stimulates renal glomerular sodium-potassium adenosine triphosphatase activity.
The effect of insulin on total and ouabain-inhibited membrane-bound adenosine triphosphatase (ATPase) activity in renal glomeruli isolated from adult white rats was examined. In concentrations of 1-10 micrograms/ml, insulin significantly stimulated the ouabain-inhibited (Na+ + K+)-ATPase activity, without affecting total (composite) ATPase activity. These results, coupled with previous findings demonstrating that glomerular (Na+ + K+)-ATPase activity is reduced in acute streptozotocin diabetes, suggest that the renal glomerulus is a target tissue with respect to this biologic effect of insulin.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology; D007328:Insulin / Q000494:pharmacology*; D007678:Kidney Glomerulus / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010042:Ouabain / Q000494:pharmacology; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000032:analysis*
D007328:Insulin; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase