Murine leukemia virus long terminal repeat sequences can enhance gene activity in a cell-type-specific manner.
We tested the ability of sequences in the long terminal repeat (LTR) of a mink cell focus-forming (MCF) murine leukemia virus to function as an enhancer in a cell-type-specific manner. In a stable transformation assay, the MCF or Akv LTR and the simian virus 40 enhancer had similar activities in murine fibroblasts. In contrast, the MCF LTR had a significantly greater activity in murine T lymphoid cells than did either the simian virus 40 enhancer or the Akv LTR.
D000818:Animals; D001483:Base Sequence; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D004742:Enhancer Elements, Genetic; D005347:Fibroblasts; D005786:Gene Expression Regulation; D005809:Genes, Regulator; D009052:Leukemia Virus, Murine / Q000235:genetics*; D008214:Lymphocytes; D051379:Mice; D012091:Repetitive Sequences, Nucleic Acid