MPTP causes a non-reversible depression of synaptic transmission in mouse neostriatal brain slice.
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) causes a Parkinson's disease-like syndrome. The mechanism of MPTP's neurotoxicity is unknown; however, one hypothesis is that MPP+ (1-methyl-4-phenylpyridinium), a product of MPTP's oxidation, is the neurotoxic agent. Using a mouse brain slice preparation we studied the effects of MPTP and MPP+ on synaptic transmission. We found MPTP caused a decrease in amplitude of an excitatory synaptic response not reversed by washing. This non-reversible action of MPTP was prevented by GBR-32 and pargyline. MPP+s caused a decrease in synaptic transmission, but this decrease was reversed by washing. The results suggest that the toxic effect of MPTP on synaptic transmission is not accounted for by the action of MPP+.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D015655:1-Methyl-4-phenylpyridinium; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects* / Q000502:physiology; D018492:Dopamine Antagonists; D004558:Electric Stimulation; D066298:In Vitro Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D009433:Neural Inhibition / Q000187:drug effects*; D010293:Pargyline / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D011726:Pyridinium Compounds / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects
D018492:Dopamine Antagonists; D010879:Piperazines; D011725:Pyridines; D011726:Pyridinium Compounds; C044630:1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine; D010293:Pargyline; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D015655:1-Methyl-4-phenylpyridinium