The neuromuscular blocking activity of spectinomycin on the rat sciatic nerve-gastrocnemius muscle preparation.
Spectinomycin displays a dose-dependent neuromuscular blocking activity in vivo. The neuromuscular blockade elicited by spectinomycin is potentiated by d-tubocurarine. Neostigmine methylsulfate is unable to reverse the neuromuscular blocking activity of spectinomycin, whereas calcium chloride counteracts the neuromuscular blockade induced by this antibiotic.
D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D009466:Neuromuscular Blocking Agents; D009469:Neuromuscular Junction / Q000187:drug effects*; D051381:Rats; D000198:Spectinomycin / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects; D014403:Tubocurarine / Q000494:pharmacology
D009466:Neuromuscular Blocking Agents; D000198:Spectinomycin; D014403:Tubocurarine