Profiling of organic acids and polyols in nerves of uraemic and non-uraemic patients.
Organic acids, polyols and lipid-bound polyols in the cauda equina nerves of uraemic patients and non-uraemic patients were analysed with high-resolution gas chromatography-mass spectrometry. In the uraemic nervous tissue, the concentrations of myoinositol and 4-hydroxyphenylacetic acid were increased. Levulinic acid was first detected in the nervous tissue as a normal component. 1-Deoxyglucose and free and lipid phosphatide scylloinositol were detected in the nervous tissue as normal components.
D000143:Acids / Q000032:analysis*; D000438:Alcohols / Q000032:analysis*; D002420:Cauda Equina / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007294:Inositol / Q000032:analysis; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000378:metabolism; D011108:Polymers / Q000032:analysis*; D014511:Uremia / Q000150:complications / Q000378:metabolism*
D000143:Acids; D000438:Alcohols; D011108:Polymers; C024617:polyol; D007294:Inositol