Stimulation of noradrenaline synthesis by the calcium ionophore A23187 and its modulation by presynaptic receptors.
Noradrenaline (NA) synthesis in rat hippocampal synaptosomes is increased by calcium ionophore, A23187, in the presence of calcium. Activation of presynaptic muscarinic, gamma-aminobutyric acidB (GABAB) and alpha 2-adrenergic receptors causes inhibition of the ionophore-stimulated synthesis. The results suggest that different mechanisms mediate the depression by presynaptic receptors of NA release and NA synthesis.
D000243:Adenosine Deaminase / Q000378:metabolism; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D011963:Receptors, GABA-A / Q000502:physiology; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D011983:Receptors, Purinergic; D013574:Synaptosomes / Q000378:metabolism
D011943:Receptors, Adrenergic, beta; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D017981:Receptors, Neurotransmitter; D011983:Receptors, Purinergic; D000001:Calcimycin; D000243:Adenosine Deaminase; D009638:Norepinephrine