[Change in the protein kinase activity of glandular stomach mucosa in rats during malignant transformation].
Changes in the activity of protein kinases in the glandular stomach mucosa of rat were studied in the case of carcinogenesis induced by N-methyl-N'-nitro-N'-nitrosoguanidine. No essential changes in the activity of cAMP-dependent protein kinase (histone kinase) were found in the mucosa as well as in tissues of the developed tumours of the rat glandular stomach. The activity of cAMP-independent protein kinase (casein kinase) increased significantly 3 months after the beginning of the carcinogen administration and at the late stages (after 12-15 months) it was decreased considerably both in the glandular stomach tumours and in the stomach mucosa without the characters of the malignant growth. It is supposed that changes in the activity of casein kinase in the stomach mucosa at the late carcinogenesis stages are associated with the neoplastic transformation and precede the appearance of morphological characters of the malignization.
D000818:Animals; D047388:Casein Kinases; D005753:Gastric Mucosa / Q000201:enzymology*; D008297:Male; D008769:Methylnitronitrosoguanidine; D006656:Protamine Kinase / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism*; D051381:Rats; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000201:enzymology
D008769:Methylnitronitrosoguanidine; D011494:Protein Kinases; D047388:Casein Kinases; D006656:Protamine Kinase
Izmeneniia aktivnosti proteinkinaz slizistoĭ obolochki zhelezistogo zheludka krysy pri zlokachestvennoĭ transformatsii.