title: An in vitro reactivation system for investigation of herpes simplex virus latency.
abstract: An in vitro reactivation system for investigation of herpes simplex virus latency which is inexpensive, simple, and convenient to establish and operate is presented. The system is useful for investigation of compounds that may be involved in suppression or augmentation of herpes simplex virus reactivation. The uses of this model in exploring the mechanism of HSV reactivation, in screening for drugs which affect this process, and in testing their mode of action are discussed.
mesh_terms: D000212:Acyclovir / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005727:Ganglia, Spinal / Q000166:cytology; D007213:Indomethacin / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D011930:Reaction Time; D018139:Simplexvirus / Q000187:drug effects / Q000254:growth & development*; D014775:Virus Activation; D014779:Virus Replication
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir; D007213:Indomethacin