Reduced tuberoinfundibular dopaminergic neuronal function in rats after long-term withdrawal of estrogen treatment.
Hypothalamic fragments from female rats treated repeatedly with estradiol valerate (EV) and bearing prolactin (PRL)-secreting tumors contained, seven months after the last EV injection, lower concentrations of dopamine (DA) than age-matched controls. Depolarizing concentrations of K+ (35 mM) and amphetamine (50 microM) evoked in PRL-secreting tumor bearing rats an endogenous DA release significantly lower than in controls.
D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology*; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000503:physiopathology*; D066298:In Vitro Techniques; D009474:Neurons / Q000502:physiology*; D010911:Pituitary Neoplasms / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D004966:Estrogens, Conjugated (USP); D004958:Estradiol; D011388:Prolactin; D011188:Potassium; D003913:Dextroamphetamine; D004298:Dopamine