Sequential antibody changes following ulcerative herpetic keratitis.
Blood and tear levels of immunoglobulins against herpes simplex virus (HSV) were examined in 28 patients with dendritic keratitis over a period of 28 days. By means of an indirect micro-immunofluorescent technique blood and tear HSV IgG were detected, but neither circulating HSV IgM nor local HSV IgA were found. Over a four-week interval non-diagnostic fluctuations of HSV IgG occurred in most patients, though seven (25%) developed a rising blood IgG titre. Tear IgG appeared to be an exudate from blood. HSV was isolated from 68% of corneal swabbings and 11% of conjunctival swabbings. This study provides guidelines for laboratory testing in recurrent herpetic keratitis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis*; D003228:Conjunctiva / Q000276:immunology; D003315:Cornea / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007635:Keratitis, Dendritic / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D018139:Simplexvirus / Q000276:immunology; D013666:Tears / Q000276:immunology; D013997:Time Factors
D000914:Antibodies, Viral; D007074:Immunoglobulin G