Autoradiographic localization of thyrotropin-releasing hormone receptors in amyotrophic lateral sclerosis spinal cord.
We used quantitative autoradiography to determine the density of thyrotropin-releasing hormone (TRH) receptors in discrete regions of spinal cord from four patients with amyotrophic lateral sclerosis (ALS). The density and distribution of [3H]-3-methyl-histidine-TRH binding to TRH receptors differed from reported values in normal individuals, with fewer TRH receptors in lamina II and lamina IX. The diminished concentration of TRH receptors in lamina IX may reflect the loss of motor neurons in ALS.
D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D001345:Autoradiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000032:analysis*; D018025:Receptors, Thyrotropin-Releasing Hormone; D013116:Spinal Cord / Q000032:analysis
D011956:Receptors, Cell Surface; D018025:Receptors, Thyrotropin-Releasing Hormone