[Effect of guanosine-5'-monophosphate and inosine on the isolated heart of the frog].
The chronotropic and inotropic effects of guanosine-5'-monophosphate (5'-GMP) and inosine were investigated in isolated frog hearts. 5'-GMP induced biphasic chronotropic and inotropic responses: positive those were inhibited with propranolol, the negative inotropic response could not be inhibited with atropine. Inosine was able to enhance the positive inotropic response to 5'-GMP.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004347:Drug Interactions; D006150:Guanine Nucleotides / Q000494:pharmacology*; D006157:Guanosine Monophosphate / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007288:Inosine / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology; D011896:Rana temporaria
D006150:Guanine Nucleotides; D007288:Inosine; D001285:Atropine; D006157:Guanosine Monophosphate; D011433:Propranolol
Deĭstvie guanozin-5'-monofosfata i inozina na izolirovannoe serdtse liagushki.