title: Pyridazinyl-GABA derivatives as GABA and glycine antagonists in the spinal cord of the cat.
abstract: Of two arylaminopyridazine derivatives of gamma-aminobutyric acid (GABA) tested as antagonists of the inhibitory actions of glycine and GABA in the spinal cord of pentobarbitone-anaesthetized cats, one - SR95531 - was sufficiently selective to be of use in microelectrophoretic investigations of GABA-mediated synaptic transmission.
mesh_terms: D000818:Animals; D002415:Cats; D018756:GABA Antagonists; D005998:Glycine / Q000037:antagonists & inhibitors*; D007395:Interneurons / Q000187:drug effects; D011724:Pyridazines / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects*; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D018756:GABA Antagonists; D011724:Pyridazines; C044796:2-(carboxy-3'-propyl)-3-amino-4-methyl-6-phenylpyridazinium chloride; C049853:gabazine; D005998:Glycine