Deoxyribonucleic acid polymorphism in the apolipoprotein A-1-C-III gene cluster. Association with hypertriglyceridemia.
A DNA sequence polymorphism, revealed by digestion of human DNA with the restriction endonuclease Sst-1 and hybridization with an apolipoprotein A-I complementary DNA clone, has been shown to be located in or close to the 3' noncoding region of the apolipoprotein C-III gene. This polymorphism is found in significantly increased prevalence (P less than 0.001) in Caucasian hypertriglyceridemic subjects compared with race-matched controls, and its distribution in normal individuals of differing racial origins is reported. Furthermore, no alteration of high density lipoprotein or apolipoprotein A-I and apolipoprotein C-III phenotypes was observed in individuals with or without the polymorphism.
D000293:Adolescent; D016632:Apolipoprotein A-I; D053305:Apolipoprotein C-III; D001054:Apolipoproteins A / Q000097:blood / Q000235:genetics*; D001056:Apolipoproteins C / Q000097:blood / Q000235:genetics*; D002648:Child; D002681:China / Q000208:ethnology; D004247:DNA / Q000235:genetics*; D004262:DNA Restriction Enzymes / Q000378:metabolism; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D005796:Genes; D005838:Genotype; D006801:Humans; D006953:Hyperlipoproteinemia Type IV / Q000235:genetics*; D007525:Isoelectric Focusing; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D044465:White People
D016632:Apolipoprotein A-I; D053305:Apolipoprotein C-III; D001054:Apolipoproteins A; D001056:Apolipoproteins C; D008075:Lipoproteins, HDL; D004247:DNA; D004262:DNA Restriction Enzymes; C024408:endodeoxyribonuclease SacI; D015252:Deoxyribonucleases, Type II Site-Specific