title: The same "TATA" box beta-thalassemia mutation in Chinese and US blacks: another example of independent origins of mutation.
abstract: A Chinese beta +-thalassemia gene in a new haplotype was chosen for cloning and sequencing. The mutation identified was an A-G transition at position -29 in the TATA box of the beta-globin gene. This mutation has not been seen previously in Chinese but has been documented in American blacks on a different chromosomal background. This observation provides further evidence for independent origins of the same mutation in distinct ethnic groups.
mesh_terms: D044466:Asian People; D001483:Base Sequence; D044383:Black People; D002681:China; D004262:DNA Restriction Enzymes; D005838:Genotype; D005914:Globins / Q000235:genetics*; D006801:Humans; D009154:Mutation; D013789:Thalassemia / Q000235:genetics*; D014481:United States; D001741:Black or African American
chemical_list: D005914:Globins; D004262:DNA Restriction Enzymes