title: Soft tissue sarcoma as second malignant lesion after therapy for Hodgkin's disease. Report of two cases and review of the literature.
abstract: Two cases of soft tissue sarcoma following treatment of nodular sclerosing Hodgkin's disease are described. One patient developed a malignant schwannoma after radiotherapy, the other was diagnosed as having a malignant fibrous histiocytoma after treatment with radiation and chemotherapy. Both secondary malignancies arose within the irradiated field after a latent period ranging from 9.5 years in the first to 21 years in the second case. A review of the pertinent literature is given and previous reports of malignant tumors and leukemias following therapy for Hodgkin's disease are summarized.
mesh_terms: D000328:Adult; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000209:etiology / Q000473:pathology; D006689:Hodgkin Disease / Q000473:pathology / Q000628:therapy*; D006801:Humans; D009378:Neoplasms, Multiple Primary; D009442:Neurilemmoma / Q000209:etiology / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects*; D012983:Soft Tissue Neoplasms / Q000209:etiology*