The blood-retinal barrier permeability to fluorescein in juvenile diabetics treated with continuous subcutaneous insulin infusion.
To determine possible quantitative changes of the blood-retinal barrier permeability in juvenile diabetics treated with continuous subcutaneous insulin infusion (CSII), we studied seven patients (three females and four males, mean age 36 years) with a mean duration of the disease of 19 years. The pump treatment was continued for seven to eight days and during the treatment mean blood glucose level decreased to near-normal values (before 13.7 mmol per liter - during 6.2 mmol per liter). There was no changes in retinal appearance during treatment. Determination of the blood-retinal barrier permeability showed no quantitative changes during the one week treatment with CSII (mean permeability before 7.6 10 divided by 7 cm/sec - mean permeability during 7.8 10 divided by 7 cm/sec). In order to quantitate possible long-term reversibility of break-down of the blood-retinal barrier we have design to extend the treatment period.
D000328:Adult; D002199:Capillary Permeability; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D005260:Female; D019793:Fluorescein; D005452:Fluoresceins / Q000378:metabolism*; D006801:Humans; D007332:Insulin Infusion Systems; D008297:Male; D008875:Middle Aged; D012171:Retinal Vessels / Q000378:metabolism*
D005452:Fluoresceins; D019793:Fluorescein