Peripheral neuropathy associated with high-dose Ara-C therapy.
Central nervous system toxicity associated with high-dose cytosine arabinoside (Ara-C) therapy (HD Ara-C) is well known. The authors report the case of a severe isolated peripheral polyneuropathy due to HD Ara-C. Electrophysiologic changes and histologic observations were consistent with axonal degeneration and scattered destruction of myelin sheaths. This observation emphasizes the need for careful complete neurologic evaluation for patients receiving HD Ara-C treatment.
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001369:Axons / Q000503:physiopathology; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects*; D004576:Electromyography; D004594:Electrophysiology; D005260:Female; D006801:Humans; D007866:Leg; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D009132:Muscles / Q000294:innervation; D009460:Neurologic Examination; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D014855:Wallerian Degeneration / Q000187:drug effects
D003561:Cytarabine