title: [Synthesis and analysis of conformationally restricted analogs of peptide inhibitors of the angiotensin-converting enzyme].
abstract: To investigate conformations of peptide inhibitors of the angiotensin-converting enzyme in the enzyme-inhibitor complex, the synthesis, studies of inhibitory activity, and conformational calculations of analogues of bradykinin-potentiating peptides with N-methylalanine or D-alanine in place of L-proline or L-alanine residues have been carried out. All the analogues showed a sharp decrease of inhibitory activity in comparison with the natural peptides, that might be considered as an indirect confirmation of the earlier proposed "conformation of inhibition" of the above-mentioned peptides.
mesh_terms: D000595:Amino Acid Sequence; D000806:Angiotensin-Converting Enzyme Inhibitors; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D066298:In Vitro Techniques; D008958:Models, Molecular; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D011487:Protein Conformation
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D009842:Oligopeptides
vernacular_title: Sintez i issledovanie konformatsionno ogranichennykh analogov peptidnykh ingibitorov angiotenzinprevrashchaiushchego fermenta.