title: Rapid reductive-carboxylation of secondary amines, one pot synthesis of N'-(4-11C-methyl)imipramine.
abstract: A new rapid high yield synthesis of radiolabeled N'-(4-11C-methyl)imipramine has been developed using a reductive-carboxylation approach, in which 11CO2 is reacted with either N'-trimethylsilyldesimipramine or N'-lithium derivative of desimipramine, followed by lithium aluminum hydride reduction, to give no carrier added or carrier added 11C-labeled imipramine respectively. The final product is characterized by chromatographic and spectroscopic methods.
mesh_terms: D002250:Carbon Radioisotopes; D007099:Imipramine / Q000138:chemical synthesis; D007553:Isotope Labeling / Q000379:methods*; D011854:Radiochemistry
chemical_list: D002250:Carbon Radioisotopes; D007099:Imipramine