Serotonin 5-HT1 receptors mediate inhibition of cyclic AMP production in neurons.
In purified striatal and cortical neurons in primary culture, serotonin (5-HT) stimulated basal cyclic AMP production (EC50, 0.5 microM) 2.5- and 1.5-fold, respectively. The 5-HT1 selective agonists, RU 24969 and 8-hydroxy-2-(di-n-propylamino)tetralin (PAT), did not stimulate cyclic AMP production. However, 5-HT, RU 24969 and PAT inhibited VIP-stimulated cyclic AMP formation in a dose-dependent manner. The actions of selective agonists and antagonists at 5-HT receptors mediating attenuation of cyclic AMP production suggest that they may be of the 5-HT1 subtype.
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D000242:Cyclic AMP / Q000096:biosynthesis*; D005260:Female; D005333:Fetus / Q000378:metabolism; D007211:Indoles / Q000494:pharmacology; D007650:Ketanserin; D008711:Metergoline / Q000494:pharmacology; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D010880:Piperidines / Q000494:pharmacology; D011247:Pregnancy; D011985:Receptors, Serotonin / Q000502:physiology*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D007211:Indoles; D010880:Piperidines; D011985:Receptors, Serotonin; D013764:Tetrahydronaphthalenes; D008711:Metergoline; C025145:5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole; D014660:Vasoactive Intestinal Peptide; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D007650:Ketanserin; D000242:Cyclic AMP; D000262:Adenylyl Cyclases