Heterogeneous distribution of benzodiazepine receptors in the human striatum: a quantitative autoradiographic study comparing the pattern of receptor labelling with the distribution of acetylcholinesterase staining.
The distribution of benzodiazepine receptors in the human striatum was studied by quantitative autoradiography following in vitro labelling of cryostat sections with [3H]flunitrazepam, and the pattern of receptor-labelling was compared to the distribution of acetylcholinesterase (AChE) staining in adjacent sections. A heterogeneous pattern of benzodiazepine receptors was found in all regions of the striatum. The highest densities of receptors were seen in the ventral striatum (nucleus accumbens and olfactory tubercle), where very dense receptor patches aligned with both AChE-poor and AChE-rich regions. The dorsal striatum (caudate nucleus and putamen) contained lower concentrations of benzodiazepine receptors, but dense receptor patches were still evident (especially in the caudate nucleus) and these aligned with AChE-poor striosomes.
D000110:Acetylcholinesterase / Q000032:analysis*; D000328:Adult; D001345:Autoradiography; D002675:Child, Preschool; D003342:Corpus Striatum / Q000378:metabolism*; D005260:Female; D005445:Flunitrazepam; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D011869:Radioligand Assay; D011963:Receptors, GABA-A / Q000378:metabolism*
D011963:Receptors, GABA-A; D005445:Flunitrazepam; D000110:Acetylcholinesterase