Polyomavirus middle T protein encoded by a retrovirus transforms nonestablished chicken embryo cells.
A murine retrovirus encoding the middle T protein of polyomavirus infected and transformed nonestablished chicken embryo cells. The infected cultures formed colonies in soft agar-containing medium and released infectious transforming virus. Middle T protein expressed in the transformed chicken cells associated with p60c-src and, in immunoprecipitates, enhanced the tyrosine protein kinase activity of p60c-src.
D000818:Animals; D000957:Antigens, Viral, Tumor / Q000235:genetics*; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D002642:Chick Embryo; D004274:DNA, Recombinant; D004789:Enzyme Activation; D005786:Gene Expression Regulation; D009052:Leukemia Virus, Murine / Q000235:genetics*; D008970:Molecular Weight; D015688:Oncogene Protein pp60(v-src); D010750:Phosphoproteins / Q000378:metabolism; D011120:Polyomavirus / Q000235:genetics* / Q000276:immunology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D012191:Retroviridae Proteins / Q000378:metabolism
D000957:Antigens, Viral, Tumor; D004274:DNA, Recombinant; D010750:Phosphoproteins; D012191:Retroviridae Proteins; D011505:Protein-Tyrosine Kinases; D015688:Oncogene Protein pp60(v-src)