Enhanced expression of the c-myc gene in bovine leukemia virus-induced bovine tumors.
We have detected elevated levels of c-myc gene expression in neoplastic cells from all seven bovine leukemia virus (BLV)-induced bovine tumors examined, but not in BLV-infected, nonneoplastic lymphoid cells. No rearrangement or amplification of the c-myc gene could be demonstrated in any of the BLV-induced tumors. Furthermore, BLV proviral DNA was found to have no preferred site of integration in these tumors. The possible mechanisms of enhanced expression of the c-myc gene in BLV-induced tumors have been discussed.
D000818:Animals; D002417:Cattle; D004273:DNA, Neoplasm / Q000032:analysis; D001909:Leukemia Virus, Bovine; D007942:Leukemia, Experimental / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D016271:Proto-Oncogene Proteins c-myc; D011519:Proto-Oncogenes; D014158:Transcription, Genetic
D004273:DNA, Neoplasm; D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc