The influence of Bordetella pertussis and its constituents on the beta-adrenergic receptor in the guinea pig respiratory system.
In the present study, the effect of vaccination of guinea pigs with Bordetella pertussis was investigated, 4 days after treatment, on the cholinergic and beta-adrenergic receptor function in isolated tracheal spirals and the number of beta-adrenoceptor binding sites in guinea pig lung. It was found that B. pertussis caused an impairment in the beta-adrenoceptor function and a decrease in its number. Similar results were obtained with endotoxin. Leucocytosis promoting factor, however, was ineffective. These results indicate that endotoxin is the constituent responsible for the beta-adrenoceptor blocking effects of the bacterium. Also the combined whole cell diphtheria, B. pertussis and tetanus toxoid vaccine induced a beta-adrenoceptor blockade; the acellular vaccine was less effective. The results obtained with the B. pertussis vaccines are discussed in relation to the possible side-effects that sometimes occur after immunization of infants.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D004731:Endotoxins / Q000494:pharmacology; D004837:Epinephrine / Q000378:metabolism; D006168:Guinea Pigs; D007545:Isoproterenol / Q000494:pharmacology; D008168:Lung / Q000502:physiology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D010567:Pertussis Vaccine / Q000494:pharmacology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D013745:Tetanus Toxoid / Q000494:pharmacology; D014018:Tissue Distribution; D014132:Trachea / Q000502:physiology*
D004731:Endotoxins; D010567:Pertussis Vaccine; D011943:Receptors, Adrenergic, beta; D013745:Tetanus Toxoid; D002217:Carbachol; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine