[Mechanisms of hypertension in patients with terminal kidney failure on programmed hemodialysis].
The state of some mechanisms involved in AP regulation was studied in 18 patients with terminal renal failure (TRF) on programmed hemodialysis for 7-9 mos. The imbalance of extra- and intracellular sodium, potassium and water causing hypertension, was noted in TRF patients. TRF patients revealed (against a background of the normal activity of plasma renin) a high activity of carboxycathepsin resulting in the creation of conditions for enhanced kinin degradation playing a depressor role and for intense angiotensin II formation, being an important mechanism of persistent hypertension. An increase in the activity of carboxycathepsin can be one of the reasons of hyperaldosteronemia detected in the patients. A single session of hemodialysis does not significantly influence the activity of carboxycathepsin.
D000328:Adult; D000450:Aldosterone / Q000097:blood; D001794:Blood Pressure; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications* / Q000628:therapy; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011188:Potassium / Q000097:blood; D006435:Renal Dialysis / Q000009:adverse effects*; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood; D013997:Time Factors
D000450:Aldosterone; D012964:Sodium; D007703:Peptidyl-Dipeptidase A; D012083:Renin; D011188:Potassium
Nekotorye mekhanizmy gipertenzii u bol'nykh s terminal'noĭ pochechnoĭ nedostatochnost'iu, nakhodiashchikhsia na programmnom gemodialize.