A human c-src gene resides on the proximal long arm of chromosome 20 (cen----q131).
A molecular clone of v-src, the oncogene of Rous sarcoma virus, was used to detect and regionally localize a human c-src proto-oncogene on chromosome #20. The human c-src gene, detected as either a 28-kbp EcoRI DNA fragment or as a 15.4-kbp BglII DNA fragment, was localized to 20 cen----q131 by filter hybridization analysis of DNAs from human-rodent somatic cell hybrids. The results indicate that c-src is on the same chromosome arm as aberrations associated with myeloproliferative disease, although the possible involvement of c-src in these aberrations is unknown.
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000235:genetics*; D002874:Chromosome Mapping; D002903:Chromosomes, Human, 19-20; D006224:Cricetinae; D003412:Cricetulus / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D051379:Mice / Q000235:genetics; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes