title: Suspected adverse methylphenidate-imipramine interactions in children.
abstract: Two cases are presented which illustrate the dangers inherent in utilizing a polypharmacy approach in treating children with psychotropic medication. In each case, severe adverse effects, including cognitive and mood deterioration, were experienced by the child when treated with a combination of methylphenidate and imipramine. Possible mechanisms at the neurotransmitter level are described as postulated determinants for this pharmacological interaction.
mesh_terms: D000293:Adolescent; D000374:Aggression / Q000187:drug effects; D002648:Child; D004347:Drug Interactions; D006801:Humans; D007099:Imipramine / Q000009:adverse effects*; D008297:Male; D008774:Methylphenidate / Q000009:adverse effects*; D011950:Receptors, Cholinergic / Q000187:drug effects; D017981:Receptors, Neurotransmitter / Q000187:drug effects
chemical_list: D011950:Receptors, Cholinergic; D017981:Receptors, Neurotransmitter; D008774:Methylphenidate; D007099:Imipramine