Long-term amitriptyline treatment alters the affinity state of alpha 2 adrenoceptors in rabbit hindbrain.
The effects of 7 and 21 days amitriptyline treatment on brain stem alpha 2 adrenoceptor number and affinity state and on the in vivo depressor response to intracisternal clonidine were examined in male New Zealand white rabbits.
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001933:Brain Stem / Q000187:drug effects*; D002531:Cerebellum / Q000187:drug effects*; D003000:Clonidine / Q000494:pharmacology; D004146:Dioxanes / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D006339:Heart Rate / Q000187:drug effects; D019329:Idazoxan; D008297:Male; D011817:Rabbits; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000378:metabolism; D015016:Yohimbine / Q000378:metabolism
D004146:Dioxanes; D011942:Receptors, Adrenergic, alpha; D000639:Amitriptyline; D015016:Yohimbine; D003000:Clonidine; D019329:Idazoxan; D004837:Epinephrine