Intracellular binding proteins for retinol and retinoic acid in early and term human placentas.
Specific binding of both [3H]retinol and [3H]retinoic acid was observed in the cytosol fraction from term placentas and specific binding of [3H]retinol but not [3H]retinoic acid was detected in the cytosol fraction from placentas of 8-12 week pregnancies. The elution volume of the bound radioactivity on Sephadex G-100 column chromatography was within the range expected for proteins of molecular weight 14 500, in agreement with the results of others for cellular retinol- and retinoic acid-binding proteins from other tissues. The role of these proteins in mediating the effects of vitamin A on growth and differentiation of the placenta and fetus has yet to be determined.
D002352:Carrier Proteins / Q000032:analysis*; D002498:Centrifugation; D002850:Chromatography, Gel; D003600:Cytosol / Q000032:analysis; D005260:Female; D006801:Humans; D010920:Placenta / Q000032:analysis*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011263:Pregnancy Trimester, Third; D018168:Receptors, Retinoic Acid; D012177:Retinol-Binding Proteins / Q000032:analysis*; D014212:Tretinoin / Q000378:metabolism*; D014801:Vitamin A / Q000378:metabolism
D002352:Carrier Proteins; D018168:Receptors, Retinoic Acid; D012177:Retinol-Binding Proteins; D014801:Vitamin A; D014212:Tretinoin