title: Cardiotonic and coronary vasodilatatory effects of amrinone in the canine heart-lung preparation with a support dog as compared with those of dobutamine.
abstract: Analysis of the relative magnitude of the positive inotropic and chronotropic effects and the coronary vasodilating effects of amrinone conducted in the canine heart-lung preparation with a support dog in comparison with those of dobutamine demonstrated that amrinone was a preferential coronary vasodilator rather than a selective positive inotropic agent. An in vitro experiment in the canine papillary muscle suggested the initiation of the slow response action potential as a mechanism of the positive inotropic effect of amrinone.
mesh_terms: D000631:Aminopyridines / Q000494:pharmacology*; D000676:Amrinone; D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects*; D000242:Cyclic AMP / Q000502:physiology; D004280:Dobutamine / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010210:Papillary Muscles / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000631:Aminopyridines; D002316:Cardiotonic Agents; D014665:Vasodilator Agents; D004280:Dobutamine; D000242:Cyclic AMP; D000676:Amrinone