title: Statistical analyses of clinico-pathological, virological and epidemiological data on lymphoid malignancies with special reference to adult T-cell leukemia/lymphoma: a report of the second nationwide study of Japan. The T- and B-Cell Malignancy Study Group.
abstract: In the present nationwide survey, 1,040 new cases of lymphoid malignancy, in most of which expression of cell surface markers had been determined, and 243 controls for a case-control study on adult T-cell leukemia/lymphoma (ATL) and other types of lymphoid malignancies were enrolled during the two years (1982-84) from 24 institutions throughout Japan. Among the 1,040 cases, 197 cases of ATL, 183 cases of T-cell lymphoma and 236 cases of non T-cell lymphoma were used in the detailed analysis of the clinico-pathological and epidemiological findings. Furthermore, 66 cases of ATL and 174 cases of other lymphoid malignancies were used for case-control analysis. In order to standardize the clinico-pathological classification throughout Japan, 20 hematologists and 12 pathologists met once a year and made the final consensus diagnosis in each case of lymphoid malignancy. Five hundred cases of non-Hodgkin's lymphoma were examined for antibody to ATL-associated antigen (ATLA). Clinico-pathological and epidemiological features for these cases were compared according to their anti-ATLA antibody status. The new results obtained from this survey are as follows: All of the patients with ATL in Kyushu had anti-ATLA antibody, but several patients with ATL in other districts had no anti-ATLA antibody, suggesting that there was no association with ATL virus (ATLV) infection in these cases. There was a difference in the histopathological patterns in non-Hodgkin's lymphoma between Kyushu and the other districts, which was due to the difference in distribution of the ATLV-associated lymphoid malignancies, namely ATL, in each area. The histopathological distribution in anti-ATLA negative cases in the Kyushu district was almost the same as that in the other districts.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D017977:Deltaretrovirus / Q000276:immunology; D005260:Female; D006801:Humans; D007564:Japan; D007938:Leukemia / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000453:epidemiology; D008223:Lymphoma / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000453:epidemiology; D012192:Retroviridae Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology; D012306:Risk; D012621:Seasons
chemical_list: D000914:Antibodies, Viral