[ Methodological evaluation and clinical significance of erythrocyte aggregation].
Red cell aggregation, which occurs in vivo when blood flow slows down, has been studied in 22 healthy subjects and 31 type I diabetics by means of Myrenne MA1 automatic aggregometer. First of all, the most reliable and precise technique has been studied: the best results have been obtained employing 25 microliters of K2-EDTA-anticoagulated blood stored between 0 and 20 degrees C for a maximum of 4 h. The present study has shown statistically significant differences (p = 0.01) between the two groups studied (controls: mean = 11.895 MEA +/- 0.863; diabetics: mean = 15.552 MEA +/- 0.985). Moreover, correlations between erythrocyte aggregability and hematochemical and rheological parameters like fibrinogen, ESR, serum proteins, plasma and blood viscosity, have been evaluated.
D001783:Blood Flow Velocity; D001798:Blood Proteins / Q000032:analysis; D001800:Blood Specimen Collection; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D004492:Edetic Acid; D004578:Electron Spin Resonance Spectroscopy; D004903:Erythrocyte Aggregation; D005260:Female; D005340:Fibrinogen / Q000097:blood; D006400:Hematocrit; D006801:Humans; D008297:Male; D008722:Methods; D011188:Potassium; D013696:Temperature; D013997:Time Factors
D001798:Blood Proteins; D005340:Fibrinogen; D004492:Edetic Acid; D011188:Potassium
Valutazione metodologica e significato clinico dell'aggregabilità eritrocitaria.