Influence of yohimbine on the ACTH-induced behavioural syndrome, in rats.
In adult male rats, yohimbine at low doses (0.1, 0.5 and 1 mg/kg i.p.) potentiated, and at high doses (30.0 mg/Kg) antagonized, the behavioural syndrome induced by the intracerebroventricular injection of ACTH 1-24 (3 micrograms/rat) (stretching-yawning syndrome and penile erections). These results support the hypothesis that brain catecholaminergic systems play a positive role in the ACTH-induced behavioural syndrome.
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects; D003366:Cosyntropin / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D015016:Yohimbine / Q000494:pharmacology*
D003366:Cosyntropin; D015016:Yohimbine; D000324:Adrenocorticotropic Hormone