title: Effect of triethyltin on enzyme activity in human adult and cord red cells.
abstract: Since organotin compounds represent an environmental health hazard, we determined the effect of triethyltin bromide (TTB) on red blood cell (RBC) enzyme activity. TTB produced a concentration-dependent inhibition of hexokinase and pyrimidine 5'-nucleotidase for both adult and cord RBC. D-Glucose, but not ATP or MgCl2, prevented the hexokinase inhibition by TTB. Glucose-6-phosphate dehydrogenase, adenylate kinase, and hypoxanthine-guanine phosphoribosyltransferase were also inhibited by TTB. Cord RBC enzymes were more resistant to the effects of TTB than were adult RBC enzymes. Although TTB is a potent inhibitor of hexokinase, physiologic concentrations of glucose appear to protect the RBC during clinical tin intoxication.
mesh_terms: D015720:5'-Nucleotidase; D000328:Adult; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005312:Fetal Blood / Q000201:enzymology*; D005947:Glucose / Q000494:pharmacology; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006593:Hexokinase / Q000097:blood; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000097:blood; D066298:In Vitro Techniques; D009708:Nucleotidases / Q000097:blood; D011247:Pregnancy; D014001:Tin / Q000494:pharmacology; D017971:Tin Compounds; D014220:Trialkyltin Compounds / Q000494:pharmacology*; D014267:Triethyltin Compounds / Q000494:pharmacology*
chemical_list: D017971:Tin Compounds; D014220:Trialkyltin Compounds; D014267:Triethyltin Compounds; C023599:stannous chloride; D014001:Tin; D005954:Glucosephosphate Dehydrogenase; D007041:Hypoxanthine Phosphoribosyltransferase; D006593:Hexokinase; D009708:Nucleotidases; D015720:5'-Nucleotidase; D005947:Glucose; C026405:bromotriethylstannane