The action of mouse liver and lung homogenates on the ESR signal of a spin-labelled antiviral compound.
A spin-labelled derivative of amantadine was prepared and added to mouse liver and lung homogenates in vitro in the presence and in the absence of inhibitors of oxidative enzymes; the kinetics of the quenching of ESR signals was followed up in different experimental variants.
D000547:Amantadine / Q000378:metabolism*; D000818:Animals; D001386:Azides / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D051379:Mice; D010084:Oxidation-Reduction / Q000187:drug effects; D011190:Potassium Cyanide / Q000494:pharmacology; D019810:Sodium Azide
D001386:Azides; D019810:Sodium Azide; D000547:Amantadine; D011190:Potassium Cyanide