title: The genes for human gastrin and cholecystokinin are located on different chromosomes.
abstract: The polypeptide hormones gastrin and cholecystokinin are structurally related, having the identical pentapeptide GWMDF located at their C-terminus. The precursors to these two hormones also show amino acid homology, suggesting that they may have a common ancestral origin. Recombinant DNA clones corresponding to gene fragments encoding human gastrin and cholecystokinin were used to determine their respective chromosomal localization by analyzing human-rodent cell lines. We have assigned the cholecystokinin gene to human chromosome 3q12-3pter and the gastrin gene to chromosome 17q.
mesh_terms: D000818:Animals; D002460:Cell Line; D002766:Cholecystokinin / Q000235:genetics*; D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3; D002902:Chromosomes, Human, 16-18; D006224:Cricetinae; D004262:DNA Restriction Enzymes; D004274:DNA, Recombinant; D005755:Gastrins / Q000235:genetics*; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D051379:Mice
chemical_list: D004274:DNA, Recombinant; D005755:Gastrins; D002766:Cholecystokinin; D004262:DNA Restriction Enzymes