Regulation of the glucose enhanced insulin pool.
Exposure of islets to high levels of glucose at a critical time leads to enhanced insulin release when later stimulated by glucose. Newly synthesized insulin is preferentially released with subsequent stimulation, implying the creation or enlargement of a separately regulated pool of insulin in response to the initial stimulus. Epinephrine via beta adrenergic receptors can trigger the discharge of the enhanced insulin pool via a beta adrenergic receptor response. Raising intracellular cAMP levels or stimulation by arginine also discharge the marked pool. The enhanced pool is accessible by several independent mechanisms.
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010477:Perfusion; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013806:Theophylline / Q000494:pharmacology
D007328:Insulin; D010643:Phenoxybenzamine; D005576:Colforsin; D001120:Arginine; D011433:Propranolol; D013806:Theophylline; D000242:Cyclic AMP; D005947:Glucose; D004837:Epinephrine