Development of specific antibodies mediating antibody-dependent cell-mediated cytotoxicity following experimental infection of cattle with bovine herpesvirus 1 and subsequent viral reactivation.
Evolution of sensitizing antibodies involved in antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-complement cell lysis and complement-facilitated ADCC was followed in bulls after primary infection by a wild strain of infectious bovine rhinotracheitis virus (bovine herpesvirus 1; BHV-1) and after experimental reactivation of the virus. These antibodies were detected between the 4th and the 7th day after primary infection, reached a maximum level after 2 weeks and rose slightly after reactivation of the virus following dexamethasone treatment. The presence of endogenous complement slightly enhanced the ADCC reaction.
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000917:Antibody Formation; D000920:Antibody-Dependent Cell Cytotoxicity; D002417:Cattle; D003165:Complement System Proteins / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D003907:Dexamethasone / Q000494:pharmacology; D006564:Herpesviridae / Q000187:drug effects / Q000254:growth & development* / Q000276:immunology; D006566:Herpesviridae Infections / Q000276:immunology*; D008297:Male; D009504:Neutrophils / Q000276:immunology; D013997:Time Factors; D014775:Virus Activation
D000914:Antibodies, Viral; D003907:Dexamethasone; D003165:Complement System Proteins