title: X-linked dominant hypophosphatemia is closely linked to DNA markers DXS41 and DXS43 at Xp22.
abstract: Two families with X-linked dominant hypophosphatemia (McKusick No. *30780) were investigated for linkage of the disease locus with several marker genes defined by cloned, single-copy DNA sequences derived from defined regions of the X chromosome. Close linkage was found with DNA markers DXS41 (p99-6) and DXS43 (pD2) at Xp22, suggesting a location of the HPDR gene on the distal short arm of the X chromosome.
mesh_terms: D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000235:genetics*; D008297:Male; D010375:Pedigree; D010710:Phosphates / Q000097:blood*; D014960:X Chromosome
chemical_list: D005819:Genetic Markers; D010710:Phosphates; D004247:DNA