title: Evidence for an endogenous peptide ligand and antagonist for PCP receptors.
abstract: alpha-Endopsychosin, an endogenous ligand for the phencyclidine receptor, has been isolated from porcine brain. The endogenous ligand is a peptide and has similar actions to PCP and is selectively distributed in the brain. A PCP analogue, Metaphit, has also been found to be an effective PCP antagonist. This antagonist may be useful for evaluating the role of the brain's alpha-endopsychosin system and may have a number of important clinical uses.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D008024:Ligands; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000302:isolation & purification* / Q000494:pharmacology; D009479:Neuropeptides; D010622:Phencyclidine / Q000378:metabolism*; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D017478:Receptors, Phencyclidine; D013552:Swine
chemical_list: D008024:Ligands; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D017981:Receptors, Neurotransmitter; D017478:Receptors, Phencyclidine; C047130:alpha-endopsychosin; D010622:Phencyclidine