The motor effect of the capsaicin-sensitive inhibitory innervation of the rat ureter.
Neurokinins activate a series of tetrodotoxin (TTX)-insensitive rhythmic contractions of the rat isolated ureter. Field stimulation or capsaicin (1-3 microM) produced a transient inhibition of neurokinin-activated ureteral motility in preparations from control but not from capsaicin-pretreated (50 mg/kg s.c.) rats. The inhibitory action of field stimulation but not that of capsaicin was prevented by TTX. It is concluded that a capsaicin-sensitive inhibitory innervation exists in the rat ureter.
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D015286:Kassinin; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D015288:Neurokinin A; D009479:Neuropeptides / Q000494:pharmacology / Q000502:physiology; D009842:Oligopeptides / Q000494:pharmacology; D051381:Rats; D013779:Tetrodotoxin / Q000494:pharmacology; D014513:Ureter / Q000187:drug effects / Q000294:innervation*
D009479:Neuropeptides; D009842:Oligopeptides; D013779:Tetrodotoxin; D015286:Kassinin; D015288:Neurokinin A; D002211:Capsaicin