Diminishing morbidity and mortality of bone marrow transplantation.
The reasons for the operational failure of bone marrow transplantation (BMT) are familiar and varied. They are the following: nonmarrow toxicity of the preparative regimen, marrow toxicity of the preparative regimen, acute graft-versus-host disease (GVHD), opportunistic infections, especially viral infections and recurrence of hematologic malignancy in the case of transplants for leukemia. This review examines operational failure of BMT and presents measures for its prevention.
D000284:Administration, Oral; D016026:Bone Marrow Transplantation; D002066:Busulfan / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003524:Cyclosporins / Q000276:immunology / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000517:prevention & control; D005759:Gastroenteritis / Q000150:complications; D006085:Graft Survival / Q000187:drug effects; D006086:Graft vs Host Disease / Q000150:complications / Q000401:mortality / Q000517:prevention & control*; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000008:administration & dosage; D007262:Infusions, Intravenous; D011014:Pneumonia / Q000150:complications; D014777:Virus Diseases / Q000150:complications / Q000401:mortality / Q000517:prevention & control*; D014916:Whole-Body Irradiation
D003524:Cyclosporins; D007074:Immunoglobulin G; D003520:Cyclophosphamide; D002066:Busulfan