Studies on the depression of gamma-aminobutyric acid potentials by phloridzin in cat dorsal root ganglion cells in vitro.
Phloridzin has been used as a tool to investigate membrane transport mechanisms. We have demonstrated that phloridzin acts to depress chloride flux resulting from activation of a gamma-aminobutyric acidA (GABAA) receptor on cat dorsal root ganglion cells. This action appears not to involve an inwardly directed chloride pump postulated for these neurons but rather affects a site associated with the GABA receptor-chloride complex.
D000818:Animals; D002415:Cats; D002463:Cell Membrane Permeability / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism; D018756:GABA Antagonists; D005727:Ganglia, Spinal / Q000187:drug effects*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D010695:Phlorhizin / Q000494:pharmacology*; D011963:Receptors, GABA-A / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects
D002712:Chlorides; D018756:GABA Antagonists; D011963:Receptors, GABA-A; D010695:Phlorhizin