Mobilization of intracellular calcium by glucagon and cyclic AMP analogues in isolated rat hepatocytes.
Separate or combined addition of cyclic AMP-dependent and Ca2+-linked hormones to isolated rat hepatocytes suspended in a low Ca2+ medium reduced the total cellular Ca. When the hormones were administered together, their effects were not additive. This suggests that both types of hormones mobilize Ca2+ from a common intracellular pool. In the presence of 1.8 mM extracellular Ca2+, the Ca2+ influx counterbalanced or even exceeded the hormone-induced Ca2+ loss, depending on the ability of the hormones to stimulate the Ca2+ influx.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D005934:Glucagon / Q000502:physiology*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D014667:Vasopressins / Q000494:pharmacology
D014667:Vasopressins; D003994:Bucladesine; D005934:Glucagon; D007545:Isoproterenol; D002118:Calcium; D004837:Epinephrine; D010646:Phentolamine