[Cholesterol-acceptor properties of high-density lipoproteins with respect to erythrocyte membranes in patients with ischemic heart disease].
A capacity of high density lipoproteins (HDL), isolated from blood of patients with ischemic heart disease, to accept cholesterol of erythrocyte membranes was studied by means of monitoring, using spectra of electron paramagnetic resonance, a disease in the correlation period of rotation, in the patterns of regularity of stearic acid nitroxyl derivatives introduced into the membranes and by a decrease in the molar ratio "cholesterol/phospholipids" in erythrocytes. HDL2 and HDL3, isolated from blood plasma of the patients, were shown to bind cholesterol less effectively after incubation with erythrocytes as compared with the corresponding lipoproteins from blood plasma of healthy persons. Relationship between the phenomenon observed and the physico-chemical properties of HDL in ischemic heart disease are discussed.
D002784:Cholesterol / Q000097:blood* / Q000378:metabolism; D003327:Coronary Disease / Q000097:blood* / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008075:Lipoproteins, HDL / Q000097:blood* / Q000378:metabolism; D008563:Membrane Lipids / Q000097:blood* / Q000378:metabolism
D008075:Lipoproteins, HDL; D008563:Membrane Lipids; D002784:Cholesterol
Kholesterin-aktseptornye svoĭstva lipoproteidov vysokoĭ plotnosti bol'nykh ishemicheskoĭ bolezn'iu serdtsa po otnosheniiu k membranam éritrotsitov.