[Synthetic Ca++-dependent proton carrier].
Influence of 1,5-(3,3'-dimethylphosphate)diphenoxy-3-oxapentane (DDOP) on conductivity (G) of bilayers of common fabbit brain lipids is studied. It has been found that DDOP increases the bilayer conductivity in the presence of Ca++ and Mg++ (G-maximum at pH = 7.0) they do not act in the presence of K+, Na+. pK'DDOP, pK"DDOP values are equal to 1.2, and 7.7 respectively as determined by titration. Formation of "pseudomacrocyclic" DDOP structure is suggested. The role of Ca++, Mg++ ions seems to consist in lipophilisation of ionized forms of DDOP.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D066298:In Vitro Techniques; D008051:Lipid Bilayers; D008563:Membrane Lipids / Q000378:metabolism*; D011522:Protons; D011817:Rabbits
D008051:Lipid Bilayers; D008563:Membrane Lipids; D011522:Protons; D002118:Calcium
Sinteticheskiĭ Ca++-zavisimyĭ perenoschik protonov.