Effect of beta-funaltrexamine on retention of passive-avoidance conditioning.
Rats received administration of an opiate antagonist immediately following single-trial passive-avoidance training. Retention of passive-avoidance conditioning was assessed 1 week after training. Compared to noninjected and vehicle-injected control groups, post-training naloxone (2.0 mg/kg) administration significantly increased retention. A comparable facilitation of retention was also observed when animals received post-training administration of beta-funaltrexamine (40 mg/kg). These data provide additional support for mu opiate receptor activity in the regulation of memory processes.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology; D017450:Receptors, Opioid, mu; D012153:Retention, Psychology / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical
D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu; D009271:Naltrexone; C024524:beta-funaltrexamine