Bovine papillomavirus genome elicits skin tumours in transgenic mice.
Transmission of the bovine papillomavirus-1 (BPV-1) genome through the mouse germ line results in the heritable formation of fibropapillomas of the skin, a tissue-specific phenotype analogous to that observed in natural BPV-1 infection of cattle. Oncogenesis is slow, with tumours first arising at 8-9 months of age, usually in areas prone to wounding. Extrachromosomal BPV-1 DNA is detected in all tumours, whereas normal tissues show only integrated DNA.
D000367:Age Factors; D000818:Animals; D052688:Bovine papillomavirus 1 / Q000235:genetics / Q000472:pathogenicity*; D004273:DNA, Neoplasm / Q000032:analysis; D004274:DNA, Recombinant; D004279:DNA, Viral / Q000235:genetics*; D005111:Extrachromosomal Inheritance; D005260:Female; D005350:Fibroma / Q000209:etiology* / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009378:Neoplasms, Multiple Primary / Q000209:etiology / Q000235:genetics; D010212:Papilloma / Q000209:etiology* / Q000235:genetics; D027383:Papillomaviridae / Q000472:pathogenicity*; D012878:Skin Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D014162:Transfection
D004273:DNA, Neoplasm; D004274:DNA, Recombinant; D004279:DNA, Viral