Simultaneous determination of radio-immunoassayable methionine-enkephalin and radioreceptor-active opiate peptides in CSF of chronic pain suffering and non suffering patients.
Radio-immunoassayable methionine-enkephalin (ME) and radioreceptor-active opiate peptide levels (OP) were determined in CSF from patients, both with and without chronic pain, under investigation for vertebral disk disease. This study showed: that there was no direct correlation between ME and OP levels in CSF; OP levels were negatively correlated with the ME/OP ratio; migraine patients had higher levels of ME; ME concentrations were reduced in patients receiving anti-inflammatory drugs (nonsteroidal): patients with chronic pain (non migraine, no anti-inflammatory drug therapy) had lower ME levels than patients without pain. The data are discussed in relation to animal models of chronic pain.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002908:Chronic Disease; D004744:Enkephalin, Methionine / Q000134:cerebrospinal fluid*; D004745:Enkephalins / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000503:physiopathology; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010148:Intractable Pain / Q000134:cerebrospinal fluid*; D011863:Radioimmunoassay / Q000379:methods; D051381:Rats; D011957:Receptors, Opioid / Q000378:metabolism
D004745:Enkephalins; D011957:Receptors, Opioid; D004744:Enkephalin, Methionine