[Effect of amiloride on the activity of membrane-bound and soluble Na+-,K+-ATPase preparations].
Amiloride (8 X 10(-4), an inhibitor of sodium channels of nonexcited membranes, inhibits the activity of Na+,K+-ATPase in the kidney cortex homogenate as well as that of the partially purified membrane-bound and lubrol-soluble Na+,K+-ATPase preparations from the cattle brain. Inhibition of Na+,K+-ATPase from different organs of various animals by amiloride, a blocker of sodium channels, indicates similarity of the molecular organization of the Na+-recognizing component both of sodium channels and sodium centres of Na+,K+-ATPase.
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000201:enzymology; D002417:Cattle; D002462:Cell Membrane / Q000201:enzymology; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000201:enzymology*; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D012995:Solubility; D013045:Species Specificity
D000584:Amiloride; D000254:Sodium-Potassium-Exchanging ATPase
Vliianie amilorida na aktivnost' membranosviazannogo i rastvorimogo preparatov Na+-,K+-ATPazy.