[Modification of the incidence and course of CMV infections following kidney transplantation by passive immunization--initial experiences with a hyperimmunoglobulin].
In 45 recipients of a renal transplant the CMV-antibody titer was measured preoperatively (ELISA method). If possible, the donors were examined likewise. All seronegative recipients of grafts of a seropositive donor were immunized passively with a CMV-hyperimmunoglobulin for 6 months (2 ml/kg bw in 3 weeks intervals). 7 patients showed that constellation, and they were treated. 4 of them demonstrated neither serological nor clinical signs of a CMV-infection at any time. In 3 patients an infection was found serologically, but only 2 showed concomitant clinical symptoms. No serious complications (pneumonia etc.) were seen. One year later all patients are doing well with a functioning graft. For this reason we think the passive immunization of a seronegative recipient of a graft from a seropositive or unexamined donor to be advisable.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000517:prevention & control*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Beeinflussung von Inzidenz und Verlauf von CMV-Infektionen nach Nierentransplantation durch passive Immunisierung--erste Erfahrungen mit einem Hyperimmunglobulin.