[Role of the polyol pathway in the occurrence of degenerative complications of diabetes].
The activity of the polyol pathway--a non insulin-dependent metabolic pathway of glucose--is increased in diabetic patients. Polyol accumulation is involved, by a myoinositol-dependent mechanism, in the pathogenesis of some degenerative complications of diabetes. Thus, sorbitol accumulation in the eye lens and in nerves seems to be an important factor in the development of cataract and in the slowing down of nerve conduction. Recent studies suggest that the polyol pathway may play a role in early structural abnormalities of retinal and renal microangiopathy. Synthetic aldose reductase inhibitors could be used for a physiopathogenic treatment of these complications, but the first trials in diabetic neuropathy proved disappointing. Further studies, prolonged and well controlled, are necessary to pronounce on the future of this new category of drugs.
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D002386:Cataract / Q000209:etiology; D003316:Corneal Diseases / Q000209:etiology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000209:etiology; D003929:Diabetic Neuropathies / Q000209:etiology; D003930:Diabetic Retinopathy / Q000209:etiology; D004594:Electrophysiology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000209:etiology; D013402:Sugar Alcohols / Q000378:metabolism*
D013402:Sugar Alcohols; D000449:Aldehyde Reductase; D005947:Glucose
Rôle de la voie des polyols dans la survenue des complications dégénératives du diabète.