An antiviral factor from Melia azedarach L. prevents Tacaribe virus encephalitis in mice.
Treatment of neonatal mice with an antiviral factor, (AVF), obtained from the leaves of Melia azedarach L. protected them against lethal encephalitis caused by Tacaribe virus inoculation. The degree of protection obtained varied from 66% to 100% depending on the virus dose. Similarly, administration of AVF to nursing mothers protected their offspring from developing virus encephalitis. AVF does not directly inactivate Tacaribe virus; it inhibits an early step (s) in the replication process in cell cultures.
D000818:Animals; D000831:Animals, Newborn; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006477:Arenaviruses, New World / Q000502:physiology; D004660:Encephalitis / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006478:Hemorrhagic Fever, American; D007774:Lactation; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D011247:Pregnancy; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D010936:Plant Extracts