Effect of amino acids on the expression of antiviral activity of different types of human interferon. I. Effect of single amino acids.
It has been observed that certain amino acids may influence the antiviral activity of different types of human interferon (IFN). The effect may be enhancing or inhibitory. A qualitative survey is provided on all three types of human IFN using 23 different amino acids. A more detailed study was carried out with 10 amino acids which proved to be active towards HuIFN-alpha. Their influences on the synergistic antiviral effects of HuIFN-alpha and HuIFN-gamma were also investigated. The dose-dependence curves of their effects on HuIFN-alpha were established.
D000596:Amino Acids / Q000494:pharmacology*; D000650:Amnion; D002460:Cell Line; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D007700:Kinetics; D011247:Pregnancy; D013329:Structure-Activity Relationship; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects*
D000596:Amino Acids; D007370:Interferon Type I; D007371:Interferon-gamma