Yohimbine attenuates the delayed lethality induced in mice by amitraz, a formamidine pesticide.
We have found that a single dose of amitraz, a formamidine pesticide, produces death in mice 2-5 days after dosing. To further examine this phenomenon, adult albino mice of both sexes were treated with either yohimbine (10 mg/kg, i.p.) or deionized water (6 ml/kg, i.p.), immediately before an injection of amitraz (600 mg/kg, i.p.) and twice daily thereafter for 8 days. Male mice treated with water were more susceptible than water-treated females to the lethal effects of amitraz. In addition, yohimbine treatment significantly decreased the number of deaths in both sexes. These data suggest that an alpha 2-adrenergic mechanism is involved in the delayed lethality produced by amitraz.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D014052:Toluidines / Q000633:toxicity*; D015016:Yohimbine / Q000494:pharmacology*
D007306:Insecticides; D011942:Receptors, Adrenergic, alpha; D014052:Toluidines; D015016:Yohimbine; C014983:amitraz