Effects of 4-aminopyridine, GABA and bicuculline on cutaneous receptive fields of cat dorsal horn neurons.
4-Aminopyridine (4-AP), bicuculline and GABA were applied locally to dorsal horn cells in the lumbar spinal cord in Nembutal-anaesthetized cats and in spinal cats. 4-AP expanded the cutaneous receptive field of 29 of 33 cells tested. Bicuculline and GABA had little or no effect on receptive field size.
D015761:4-Aminopyridine; D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D002415:Cats; D009475:Neurons, Afferent / Q000187:drug effects; D012677:Sensation / Q000187:drug effects; D012867:Skin / Q000294:innervation*; D013116:Spinal Cord / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000631:Aminopyridines; D005680:gamma-Aminobutyric Acid; D015761:4-Aminopyridine; D001640:Bicuculline