Polyphosphoinositides and cell activation.
This review surveys various aspects of the metabolism of inositol containing lipids and focuses upon the role of polyphosphoinositides in the triggering of physiological responses of platelets. Since the latter responses are evoked by a rise in cytosolic Ca2+ concentration the relationship between the phosphoinositide metabolism and the intracellular Ca2+ mobilization is discussed.
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D002118:Calcium / Q000097:blood; D006801:Humans; D007700:Kinetics; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000097:blood*; D010974:Platelet Aggregation; D013917:Thrombin / Q000502:physiology
D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D013917:Thrombin; D002118:Calcium