[Cyclic adenosine-3',5'-phosphate and guanosine-3',5'-phosphate in mouse plasma during administration of chemical compounds with different degrees of radioprotective effectiveness].
A study was made of seven radioprotective agents of different chemical classes (sulfur-containing, indolylalkylamines, and imidazol, urea and pyridasine derivatives) and also of their six structural analogs without radioprotective properties on the content of cyclic nucleotides in blood plasma and on the postirradiation survival of mice. There was a correlation between the ability of the preparations to increase the level of cyclic adenosine-3',5'-monophosphate and their radioprotective properties; with guanosine-3',5'-monophosphate, this correlation was absent.
D000818:Animals; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000097:blood* / Q000401:mortality; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013997:Time Factors; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; D000242:Cyclic AMP; D006152:Cyclic GMP
Tsiklicheskie adenozin-3',5'-monofosfat i guanozin-3',5'-monofosfat v plazme krovi mysheĭ pri vvedenii khimicheskikh soedineniĭ, obladaiushchikh razlichnoĭ protivoluchevoĭ éffektivnost'iu.