title: Sodium retention after adrenal enucleation.
abstract: Adrenal enucleation (removal of the adrenal gland, leaving the capsule intact) results in regeneration of the adrenal cortex. During the first 1-2 wk of adrenal regeneration, marked renal sodium avidity and positive sodium balance are noted. This renal sodium avidity appears mediated via adrenocorticotropin-stimulated secretion of a potent mineralocorticoid by the regenerating adrenal cortex. In this review, we have examined relationships between the histology and ultrastructure of the regenerating adrenal cortex, renal sodium handling, and adrenal steroid production at various times after the initiation of adrenal regeneration. Plasma levels of known mineralocorticoids are subnormal during the period of most intense sodium avidity, while urinary excretion of a potent mineralocorticoid, 19-nordeoxycorticosterone, has been found to be increased in rats with regenerating adrenals during this period of most intense sodium avidity. This hormone, however, is not elevated in rats with regenerating adrenals after resolution of the period of sodium avidity. In this article, we review the experimental evidence regarding the potency of this mineralocorticoid and its likely role in the sodium retention after adrenal enucleation.
mesh_terms: D000311:Adrenal Glands / Q000502:physiology* / Q000648:ultrastructure; D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D001681:Biological Assay; D002024:Bufo marinus; D003345:Corticosterone / Q000378:metabolism; D003900:Desoxycorticosterone / Q000031:analogs & derivatives / Q000378:metabolism / Q000652:urine; D005260:Female; D006706:Homeostasis; D007668:Kidney / Q000378:metabolism; D008297:Male; D009318:Natriuresis; D009399:Nephrons / Q000502:physiology; D011333:Pro-Opiomelanocortin / Q000378:metabolism; D051381:Rats; D012038:Regeneration; D012964:Sodium / Q000378:metabolism*; D013148:Spironolactone / Q000494:pharmacology; D013997:Time Factors; D001743:Urinary Bladder / Q000187:drug effects
chemical_list: D013148:Spironolactone; D003900:Desoxycorticosterone; C019026:19-nordeoxycorticosterone; D000450:Aldosterone; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D012964:Sodium; D003345:Corticosterone