Photodynamic action of erythrosin B as a toxic mechanism for infective larvae of bovine gastrointestinal nematodes.
The effect of erythrosin B on adults and 3rd stage larvae of gastrointestinal nematodes of cattle was studied by treating calves per os with 20 mg kg-1, 40 mg kg-1, and 60 mg kg-1 of the dye daily for 21 days and monitoring its effect. Erythrosin B had no detectable effect on adult nematode fecundity or viability. Data collected did indicate, however, that erythrosin B produced a consistent toxic effect on 3rd stage larvae after exposure to fluorescent light. This toxic effect was dependent upon dosage of erythrosin B administered, time of light exposure and, to a much lesser extent, the length of time the larvae were left in culture in the presence of the dye.
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000469:parasitology*; D004923:Erythrosine / Q000494:pharmacology*; D005452:Fluoresceins / Q000494:pharmacology*; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D007814:Larva; D008027:Light; D009348:Nematoda / Q000187:drug effects*; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D010777:Photochemistry
D005452:Fluoresceins; D004923:Erythrosine