The inactivation of herpes simplex virus by some Solanaceae glycoalkaloids.
The infectivity of herpes simplex virus Type I in tissue culture was inhibited by prior incubation with aqueous suspensions of glycoalkaloids in order of activity alpha-chaconine greater than alpha-tomatine greater than alpha-solasonine but not by the corresponding aglycones, solanidine, tomatidine and solasodine. However, inhibition was not only dependent on the presence of a sugar moiety since the glycone alpha-solanine was inactive under the conditions used. The glycones, but not the aglycones, showed cytopathic effects on cellular membranes of Vero cells and erythrocytes; therefore, it is suggested that inactivation of virus results from insertion of the glycones into the viral envelope.
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004144:Diosgenin; D004910:Erythrocyte Membrane / Q000187:drug effects; D009005:Monosaccharides / Q000494:pharmacology; D012756:Sheep; D018139:Simplexvirus / Q000187:drug effects*; D012991:Solanaceous Alkaloids / Q000494:pharmacology*; D012992:Solanine / Q000031:analogs & derivatives / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014053:Tomatine / Q000031:analogs & derivatives / Q000494:pharmacology
D009005:Monosaccharides; D012991:Solanaceous Alkaloids; D012992:Solanine; C011860:alpha-chaconine; C003677:tomatidine; D014053:Tomatine; C026608:alpha-solamargine; D004144:Diosgenin; C012037:solasodine; C013255:solanidine