title: Cell-mediated immune responses to Chlamydia trachomatis in mothers and infants.
abstract: Cell-mediated immunity to Chlamydia trachomatis was studied in pregnant women with chlamydial infection of the cervix, in infants born vaginally to these women, and in infants presenting with chlamydial conjunctivitis. Uninfected pregnant women and their infants were studied as controls. McCoy cell cultures were used to isolate C. trachomatis from clinical specimens. Cell-mediated immunity was measured by lymphocyte proliferative responses in vitro to stimulation by chlamydial antigens. Chlamydial IgG antibody in serum specimens was detected by a microenzyme-linked immunosorbent assay technique. The mean lymphocyte proliferative responses to chlamydial antigens were greater in infected women than in uninfected women both during pregnancy and in the postpartum period. Lymphocyte responsiveness in infected pregnant women, however, was less than in postpartum women. Despite failure to detect chlamydial infection in exposed infants, lymphocyte proliferative responses were greater in umbilical cord blood and later in peripheral blood samples from neonates born to infected mothers than in infants born to uninfected mothers. These responses were also greater in infants with chlamydial conjunctivitis than in infants of uninfected mothers. These data suggest that cellular immune responses to chlamydial antigens are increased in infected mothers and infants and that infants may acquire chlamydial cell-mediated immunity transplacentally.
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D000942:Antigens, Bacterial / Q000494:pharmacology; D002692:Chlamydia trachomatis / Q000276:immunology*; D003587:Cytomegalovirus / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D007231:Infant, Newborn; D007700:Kinetics; D008213:Lymphocyte Activation / Q000187:drug effects; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
chemical_list: D000914:Antibodies, Viral; D000942:Antigens, Bacterial