Memory effects of GABA-ergic antagonists in rats trained with two-way active avoidance tasks.
In experiments on male Wistar rats, trained and tested for memory after 24 h in a shuttle box, it was found that bicuculline applied intraperitoneally 10 min before the training in a dose of 0.5 mg/kg, improves learning and retention; bicuculline applied immediately after training in a dose of 1.0 mg/kg, improves retention. Picrotoxin, administered i.p. 20 min before training in doses of 0.25 and 0.50 mg/kg, improves learning, while in doses of 0.10-2.0 mg/kg it facilitates retention; picrotoxin, applied immediately after training in doses of 1.0 and 2.0 mg/kg, improves retention in the experimental animals. It is assumed that the GABA-ergic receptor antagonists, administered intraperitoneally, facilitate the processes of memory formation, whereby the decrease in the inhibitory effect of GABA is essential.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D001640:Bicuculline / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D001640:Bicuculline; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid