title: Human leukocyte antigens and sister chromatid exchanges in families with multiple adenomatosis coli.
abstract: To study human leukocyte antigens (HLA) and sister chromatid exchanges (SCE) in multiple adenomatosis coli (MAC), eight families were evaluated. Twenty-five subjects (14 affected members and 11 healthy relatives) were studied with HLA A, B, and C typing of peripheral lymphocytes and SCE count in cells that had replicated twice. The results of the present immunogenetic study, although limited to a small number of cases, suggest a correlation between HLA, SCE, and MAC. When the results of further investigations on larger series confirmed by clinical follow-up of these subjects are available, these methods might give useful information in predicting the risk of each family member to become affected by MAC and consequently develop a colorectal carcinoma.
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D015797:HLA-B35 Antigen; D015236:HLA-C Antigens; D006801:Humans; D008297:Male; D010375:Pedigree; D012306:Risk; D012854:Sister Chromatid Exchange
chemical_list: D006680:HLA Antigens; D015797:HLA-B35 Antigen; D015236:HLA-C Antigens; C039966:HLA-C*04 antigen