title: Molecular mechanisms involved in increasing epidermal growth factor receptor levels on the cell surface.
abstract: Various tissues and cell lines were analyzed to determine factors which regulate the epidermal growth factor (EGF) receptor level on the cell surface. At least 3 mechanisms are postulated to potentially control the EGF receptor level: gene amplification, receptor mRNA levels, and receptor half-life. The abnormal activation of any or all of these mechanisms may contribute to the high level of EGF receptors observed in squamous cell carcinomas.
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000032:analysis; D066246:ErbB Receptors; D005347:Fibroblasts / Q000032:analysis; D005784:Gene Amplification; D006207:Half-Life; D006801:Humans; D010920:Placenta / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis; D011956:Receptors, Cell Surface / Q000032:analysis* / Q000235:genetics / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D066246:ErbB Receptors