[Cytoreceptors in the molecular mechanisms of hormone action].
The author considered and analysed the phenomenological model of the functional-structural organization of a hormonal receptor molecule. He also defined the main types of hormone reception by target cells: intracellular and membranous. The paper presents some data on the structure and physicochemical characteristics of different hormone receptors, regularities and mechanisms of reception of steroid, thyroid and protein-peptide hormones (as well as catecholamines). Routes of the initiation of hormonal effects at the molecular level were shown. A special analysis was applied to the adenylate cyclase, calcium and protease routes of the initiation of hormonal effects from the cell surface. In conclusion uni- and multireceptor concepts of hormone multiple effects on cell metabolism were briefly defined.
D002395:Catecholamines / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology; D002467:Cell Nucleus / Q000502:physiology; D003600:Cytosol / Q000502:physiology; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D011941:Receptors, Adrenergic / Q000502:physiology; D011956:Receptors, Cell Surface / Q000032:analysis / Q000502:physiology*; D011987:Receptors, Steroid / Q000502:physiology; D013256:Steroids / Q000502:physiology*; D013963:Thyroid Hormones / Q000502:physiology*
D002395:Catecholamines; D011941:Receptors, Adrenergic; D011956:Receptors, Cell Surface; D011987:Receptors, Steroid; D013256:Steroids; D013963:Thyroid Hormones
Tsitoretseptory v molekuliarnykh mekhanizmakh deĭstviia gormonov.