title: [Psychotropic properties of corticotropin and its analogs].
abstract: The authors presented evidence for the effect of 6 analogues of ACTN4-10 on teaching of albino rats in a labyrinth with negative electrocutaneous reinforcement. Sixteen series of experiments on 192 rats demonstrated a positive effect of corticotropin fragments on memory processes. The activating ACTH fragment effect was shown in recording the background and bioelectrically induced rabbit brain activity in response to a photo-flash in 36 experiments on 18 animals. Three groups of 30 patients with alcohol withdrawal syndrome, posttraumatic craniocerebral effect and schizophrenia received injections of corticotropin as a therapeutic agent. A high efficacy of corticotropin in the treatment of the alcohol withdrawal syndrome and after effect of craniocerebral injury and a low efficacy and sometimes aggravation of symptoms in schizophrenia patients were shown.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D000328:Adult; D000430:Alcohol Withdrawal Delirium / Q000188:drug therapy; D000818:Animals; D001921:Brain / Q000187:drug effects; D001930:Brain Injuries / Q000188:drug therapy; D003216:Conditioning, Operant / Q000187:drug effects; D003692:Delayed-Action Preparations; D004341:Drug Evaluation; D006613:Higher Nervous Activity / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011619:Psychotropic Drugs; D011817:Rabbits; D051381:Rats; D012054:Reinforcement, Psychology; D012559:Schizophrenia / Q000188:drug therapy; D013997:Time Factors
chemical_list: D003692:Delayed-Action Preparations; D011619:Psychotropic Drugs; D000324:Adrenocorticotropic Hormone
vernacular_title: Psikhotropnye svoĭstva kortikotropina i ego analogov.