Inhibition by ceruloplasmin of the cardiac sarcolemmal adrenochrome formation.
The addition of ceruloplasmin to bovine cardiac sarcolemmal vesicles supplemented with NADPH was able to reduce the formation of adrenochrome from adrenaline. This inhibitory effect appears at 2.5 microM ceruloplasmin and it is almost complete at the level of 20 microM.
D000323:Adrenochrome / Q000096:biosynthesis*; D000818:Animals; D002417:Cattle; D002570:Ceruloplasmin / Q000494:pharmacology*; D004837:Epinephrine / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism*; D009249:NADP / Q000494:pharmacology; D012508:Sarcolemma / Q000187:drug effects / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
D013481:Superoxides; D009249:NADP; D000323:Adrenochrome; D002570:Ceruloplasmin; D004837:Epinephrine