title: [Diagnostic and therapeutic use of human anti-D (Rho) monoclonal antibodies. Evaluation and perspectives].
abstract: Human monoclonal antibodies will be essential in medicine. They are valuable tools for biological diagnosis and therapeutics. Our model, human monoclonal antibodies directed against the Rhesus D antigen can be used for the determination of the Rhesus D phenotype and for the suppression of Rh(D) immunisation in women. These new products require new procedures of preparation, new regulations for the quality controls, which will be discussed in this paper.
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis / Q000592:standards / Q000627:therapeutic use; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D001402:B-Lymphocytes / Q000378:metabolism; D001788:Blood Grouping and Crossmatching; D002472:Cell Transformation, Viral; D002999:Clone Cells / Q000378:metabolism; D004992:Ethics, Medical; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000096:biosynthesis / Q000592:standards; D007275:Injections, Intravenous; D051379:Mice; D010641:Phenotype; D011786:Quality Control; D012203:Rh Isoimmunization / Q000175:diagnosis* / Q000628:therapy; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D018029:Rho(D) Immune Globulin
chemical_list: D000911:Antibodies, Monoclonal; D007136:Immunoglobulins; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin
vernacular_title: Utilisation diagnostique et thérapeutique d'anticorps monoclonaux humains anti-D (Rho). Bilan et perspectives.