Interfering with inhibition may improve motor function.
Motor behavior not seen in newborn cats can be revealed by spinal transection and is therefore normally suppressed. Motor performance of these spinal kittens after reaching adulthood surpasses that of chronic adult-operated spinal cats but the latter display a significant improvement when GABAergic inhibition is blocked pharmacologically. Thus, inhibitory processes influence normal motor development as well as recovery of function after neurological damage.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001640:Bicuculline / Q000627:therapeutic use*; D002415:Cats; D009433:Neural Inhibition; D010264:Paraplegia / Q000188:drug therapy* / Q000503:physiopathology; D013116:Spinal Cord / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000150:complications*; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D005680:gamma-Aminobutyric Acid; D001640:Bicuculline