Cellular retinol-binding protein in normal and neoplastic human mammary gland.
The concentration of cellular retinol-binding protein (CRBP) was determined in samples of normal and neoplastic mammary gland, using a specific and sensitive radioimmunoassay. The CRBP concentration was significantly higher in neoplastic tissue, but detectable levels were also present in all samples of normal gland. Tubulo-ductal cancers had significantly lower CRBP levels than other cancer types. The CRBP concentration of the neoplastic tissue showed no correlation with the concentration of progesterone or estrogen receptor.
D000230:Adenocarcinoma / Q000032:analysis; D000328:Adult; D000367:Age Factors; D000368:Aged; D001940:Breast / Q000032:analysis*; D001943:Breast Neoplasms / Q000032:analysis* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000032:analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012177:Retinol-Binding Proteins / Q000032:analysis*; D054840:Retinol-Binding Proteins, Cellular
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D012177:Retinol-Binding Proteins; D054840:Retinol-Binding Proteins, Cellular