Preferential accumulation of 11C in human brain tumors after intravenous injection of 11C-1-pyruvate.
Regional cerebral turnover of 11C following intravenous injection of 11C-1-pyruvate was investigated in 12 patients with brain tumors. The positron emission tomography (PET) image taken at 10-15 min after the injection always demonstrated a high concentration of 11C in tumor, and thus visualized precise tumor contours. This phenomenon was not influenced qualitatively by the variation of blood flow in the tumor. Brain edema associated with the tumor was not visualized. We conclude that the localization of brain tumors would be well determined by the PET scan, using 11C-1-pyruvate.
D000328:Adult; D001254:Astrocytoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000556:secondary; D002250:Carbon Radioisotopes / Q000008:administration & dosage / Q000378:metabolism; D002560:Cerebrovascular Circulation; D005260:Female; D005909:Glioblastoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008527:Medulloblastoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000378:metabolism; D008875:Middle Aged; D010101:Oxygen Consumption; D011773:Pyruvates / Q000008:administration & dosage / Q000378:metabolism; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D011773:Pyruvates