[The effect of gamma-hydroxybutyric acid on the biosynthesis of macromolecules and metabolic paramagnetic centers in hepatocytes in acute radiation injury].
It has been shown, that the single injection of gamma-hydroxybutyric acid (GHBA) (100 mg/kg) to mice 30 min before irradiation (6 Gy) prevents whole-body irradiation-induced inhibition of DNA at early post-irradiation period. GHBA stimulates the biosynthesis of macromolecules at 1-2 days after irradiation. GHBA also prevents the increase in the degree of reduction of the mitochondrial and microsomal electron transport chains at early post-irradiation time (up to 2 h.), that takes place only under irradiation. It means, that GHBA inhibits the production of O2 radicals, which induce lipid peroxidation processes at post-irradiation period.
D000208:Acute Disease; D000818:Animals; D004247:DNA / Q000096:biosynthesis* / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D004578:Electron Spin Resonance Spectroscopy; D004579:Electron Transport; D006885:Hydroxybutyrates / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D008706:Methemoglobin / Q000032:analysis; D051379:Mice; D014176:Protein Biosynthesis; D011506:Proteins / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000378:metabolism* / Q000517:prevention & control; D011837:Radiation-Protective Agents; D012978:Sodium Oxybate / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D006885:Hydroxybutyrates; D011506:Proteins; D011837:Radiation-Protective Agents; D012978:Sodium Oxybate; D004247:DNA; D008706:Methemoglobin
Vliianie gamma-oksimaslianoĭ kisloty na biosintez makromolekul i metabolicheskie paramagnitnye tsentry v gepatotsitakh pri ostrom luchevom porazhenii organizma.