Neuropathy of vasculitic origin in a case of Garin-Boujadoux-Bannwarth syndrome with positive borrelia antibody response.
A 42-year-old man suffered from erythema chronicum migrans on different parts of the body after repeated tick bites. A few months after the last tick bite he developed a painful neuropathy in both legs with patchy disturbance of sensibility, mild weakness of the feet and loss of the right ankle jerk. Repeated determinations of antibodies against borrelia spirochetes revealed increasing IgG titres. Biopsy of the left sural nerve, which was clinically and electrophysiologically affected, showed a vasculitis of epineurial vasa nervorum and severe angiopathic lesions of the perineurium and the neural parenchyma. Parenteral high-dose penicillin treatment resolved the clinical symptoms.
D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D001733:Bites and Stings / Q000175:diagnosis; D001808:Blood Vessels; D001898:Borrelia / Q000276:immunology; D001899:Borrelia Infections / Q000175:diagnosis*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D010525:Peripheral Nerves / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis*; D013577:Syndrome; D013987:Ticks; D014650:Vasa Nervorum; D014657:Vasculitis / Q000175:diagnosis*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G