Long survival of diarrhea-associated hepatocarcinoma treated with Adriamycin and indomethacin. A case report.
The existence of tumors producing prostaglandins is well documented in the literature. At present, no case report of a prostaglandin-producing hepatocellular carcinoma has been published, to our knowledge. The authors report a patient with hepatocellular carcinoma associated with diarrhea mediated by prostaglandins, surviving 30 months after receiving treatment with indomethacin and Adriamycin. The authors will discuss the possible role played by indomethacin in the exceptional clinical course of the patient.
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000188:drug therapy; D003967:Diarrhea / Q000188:drug therapy / Q000209:etiology*; D004317:Doxorubicin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000150:complications* / Q000188:drug therapy; D008297:Male; D010257:Paraneoplastic Syndromes / Q000188:drug therapy; D011379:Prognosis
D004317:Doxorubicin; D007213:Indomethacin