Neuropathy associated with cryoglobulinemia.
A patient with severe subacute sensory ataxia was found to have an IgM (kappa) cryoglobulin. Clinical, electrophysiologic, and sural nerve biopsy studies indicated that axonal degeneration and segmental demyelination both played a role in the pathogenesis of this neuropathy. Corticosteroid therapy was associated with notable clinical improvement and a 50% decrease in cryoglobulin concentration.
D000230:Adenocarcinoma / Q000150:complications; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D003449:Cryoglobulinemia / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008297:Male; D010525:Peripheral Nerves / Q000276:immunology / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000209:etiology*; D011241:Prednisone / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000150:complications
D000974:Antibodies, Antinuclear; D011241:Prednisone