Localization of temperature-sensitive transformation mutations and back mutations in the Rous sarcoma virus src gene.
Cloning and sequencing of two temperature-sensitive transforming mutations of Rous sarcoma virus reveal that their lesions are due to distinct but close single amino acid changes near the carboxy terminus of the v-src gene product. Back mutations to wild type result from second mutations at either nearby or distant sites.
D001358:Avian Sarcoma Viruses / Q000235:genetics*; D001483:Base Sequence; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D003001:Cloning, Molecular; D005814:Genes, Viral; D009154:Mutation; D015688:Oncogene Protein pp60(v-src); D009856:Oncogene Proteins, Viral / Q000235:genetics; D009857:Oncogenes; D012191:Retroviridae Proteins / Q000235:genetics; D013696:Temperature
D009856:Oncogene Proteins, Viral; D012191:Retroviridae Proteins; D015688:Oncogene Protein pp60(v-src)