Can neonatal treatment with a related hormone adapt the receptor for itself?
Treatment of rats with endotoxin immediately after birth caused destruction of the cell membrane, resulting in depression of the thyroxin level and of the response to thyrotropin in adulthood. The thyroid gland of the rats treated neonatally with endotoxin failed to differentiate TSH from gonadotropin. Neonatal treatment (imprinting) with thyrotropin or gonadotropin after preexposure to the endotoxin improved the adult response to the exogenous hormone presented for imprinting after endotoxin. It appears that during the reconstruction stage following upon membrane perturbation in the critical period of receptor maturation, the adequate hormone or a related molecule can equally adapt the receptor for itself, but neither can fully compensate the perinatal membrane injury, nor the consequent diminution of receptor activity.
D000222:Adaptation, Physiological; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D002462:Cell Membrane / Q000187:drug effects; D004731:Endotoxins / Q000494:pharmacology; D004926:Escherichia coli; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects*; D013972:Thyrotropin / Q000378:metabolism / Q000494:pharmacology*; D013974:Thyroxine / Q000378:metabolism
D004731:Endotoxins; D011956:Receptors, Cell Surface; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013974:Thyroxine