[Behavior of the second messenger cAMP in status asthmaticus before and following administration of theophylline-ethylenediamine].
The present investigation provides evidence that the second messenger cyclic adenosine monophosphate (cAMP) shows a different reaction before and after treatment of asthmatic attack. 18 patients suffering from an asthmatic attack admitted to hospital as internal emergency cases were given intravenously 0.24 g theophylline-ethylenediamine (Euphyllin) and 10 mg benzoctamine. Blood was taken and cAMP-concentrations were tested during status asthmaticus, i.e. before theophylline was injected, and after symptoms had decreased. After injection of theophylline a relation could be shown between the clinical effect and a significant biochemical correlate. The cAMP-concentrations increased from 15.5 to 20.2 pmol/ml. The results are significant on the 1% level. It should be discussed whether there is a malfunction or a lack of receptors in asthmatic disease. The cAMP-concentrations found during status asthmaticus are low compared to those found during paroxysmal tachycardia (40 pmol/ml) and are slightly higher than those found in healthy persons. There was no depressant effect on respiration by benzoctamine; in spite of that good sedative component could be seen.
D000328:Adult; D000628:Aminophylline / Q000627:therapeutic use*; D000873:Anthracenes / Q000627:therapeutic use; D001249:Asthma / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013224:Status Asthmaticus / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D013806:Theophylline / Q000627:therapeutic use*
D000873:Anthracenes; D000628:Aminophylline; C100247:benzoctamine; D013806:Theophylline; D000242:Cyclic AMP
Verhalten des Second Messenger cAMP im Status asthmaticus vor und nach Gabe von Theophyllin-Ethylendiamin.