Resistance of line 6(3) chickens to reticuloendotheliosis-virus-induced bursa-associated lymphomas.
Chickens of lines 6(3) and 151(5) X 7(1) were inoculated with the chick syncytial strain of reticuloendotheliosis virus (REV) or with the Rous-associated virus-I of avian leukosis virus (ALV) at hatching. At 4, 10, 16, and 36 weeks post inoculation (PI), chickens were tested for REV- and ALV-induced viremia and antibody. The incidence of REV- or ALV-induced bursa-associated lymphomas in line 6(3) chickens was compared with that in line 151(5) X 7(1) chickens. Inoculation of REV at hatching resulted in immunological tolerance to the virus in line 6(3) but not in line 151(5) X 7(1) chickens. Between 70% and 100% of line 6(3) chickens remained viremic and lacked REV antibody throughout the experimental period of 36 weeks. In contrast, ALV-inoculated chickens of both lines had antibody by 16 weeks PI. The frequencies of REV- and ALV-induced bursa-associated lymphomas in line 6(3) chickens were significantly lower than in line 151(5) X 7(1) chickens. Further, the incidence of bursa-associated lymphomas induced by REV in line 151(5) X 7(1) chickens was significantly lower than that induced by ALV. These results suggest that: (1) the genetic constitution of the host may influence the immunological response to REV infection; (2) chickens resistant to ALV-induced bursa-associated lymphomas are equally resistant to such lymphomas induced by another unrelated avian retrovirus, REV; and (3) ALV is a more potent inducer of bursa-associated lymphomas than REV.
D000822:Animal Husbandry; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001354:Avian Leukosis Virus / Q000276:immunology; D002060:Bursa of Fabricius / Q000473:pathology; D002645:Chickens / Q000276:immunology*; D004198:Disease Susceptibility; D005260:Female; D008223:Lymphoma / Q000473:pathology / Q000662:veterinary*; D008297:Male; D011201:Poultry Diseases / Q000276:immunology* / Q000473:pathology; D001356:Reticuloendotheliosis virus / Q000276:immunology; D014412:Tumor Virus Infections / Q000473:pathology / Q000662:veterinary*
D000914:Antibodies, Viral