title: Early signals in the mitogenic response.
abstract: Polypeptide growth factors, regulatory peptides, and a variety of pharmacological agents acting alone or synergistically induce mitogenesis in cultured fibroblasts. The early signals in the membrane, cytosol, and nucleus promoted by these extracellular factors, together with their mitogenic effectiveness, are integrated in a unified hypothesis for the regulation of fibroblast growth.
mesh_terms: D000818:Animals; D001839:Bombesin / Q000494:pharmacology; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D004789:Enzyme Activation; D066246:ErbB Receptors; D006133:Growth Substances / Q000494:pharmacology*; D007399:Interphase; D007477:Ions / Q000378:metabolism; D008934:Mitogens / Q000494:pharmacology*; D008938:Mitosis; D008954:Models, Biological; D009857:Oncogenes; D010766:Phosphorylation; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D011493:Protein Kinase C / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: D006133:Growth Substances; D007477:Ions; D008934:Mitogens; D010982:Platelet-Derived Growth Factor; D011956:Receptors, Cell Surface; D004247:DNA; D000242:Cyclic AMP; D066246:ErbB Receptors; D011493:Protein Kinase C; D001839:Bombesin