Vasopressin excites ventromedial hypothalamic glucose-responsive neurons in vitro.
Effects of vasopressin (AVP), oxytocin (OXY), norepinephrine (NE), and glucose on the single-unit activity of hypothalamic ventromedial nucleus (VMN) in tissue slices were studied. While AVP was exclusively excitatory on 58% of the neurons, OXY could be excitatory or inhibitory and affected only 42% of the neurons. There was no correlation between the responses to these two peptides. Each of these two peptides could desensitize neuronal response to itself, but did not cross-desensitize responses to each other. These results indicate that AVP and OXY do not act on the same population of VMN neurons through the same cellular mechanism. Furthermore, only the responses to AVP were correlated to responses to glucose and NE, two agents relevant to central regulation of feeding. This correlation with responses to feeding-relevant agents and the exclusively excitatory action on the VMN, which is involved in the regulation of feeding, suggest that AVP can play a role in the regulation of feeding, particularly the feeding induced by the injection of NE into the paraventricular nucleus, that is known to alter AVP release.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism*; D046508:Culture Techniques; D004435:Eating / Q000187:drug effects*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D009433:Neural Inhibition / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D010121:Oxytocin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects*
D001786:Blood Glucose; D011956:Receptors, Cell Surface; C027786:glucose receptor; D001127:Arginine Vasopressin; D010121:Oxytocin; D009638:Norepinephrine