Binding of lincomycin to immunoglobulins has no effect on their antigen-binding capacity.
The interaction of lincomycin and immunoglobulins was examined in vitro. While lincomycin bound to the immunoglobulin molecules seemed to decrease the quantity of IgG and IgM detected by radial immunodiffusion and microzone electrophoresis, the level of specific antibodies could not be demonstrated by enzyme-linked immunosorbent assay (ELISA).
D000914:Antibodies, Viral / Q000032:analysis; D000937:Antigen-Antibody Reactions; D000941:Antigens; D003587:Cytomegalovirus / Q000276:immunology; D004587:Electrophoresis, Agar Gel; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000276:immunology / Q000378:metabolism*; D008034:Lincomycin / Q000378:metabolism / Q000494:pharmacology*; D011485:Protein Binding; D012412:Rubella virus / Q000276:immunology
D000914:Antibodies, Viral; D000941:Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D008034:Lincomycin