Intraocular 9-([2-hydroxy-1-(hydroxymethyl) ethoxy] methyl) guanine levels after intravitreal and subconjunctival administration.
Clearance studies in rabbits following intravitreal injection of 400 micrograms of 9-([2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl) guanine demonstrated levels of the antiviral at 60 hours above the in vitro ID50 for several strains of human cytomegalovirus. Intravitreal administration of this new antiviral may have therapeutic application in the treatment of acute retinal necrosis and cytomegalovirus retinitis complicating acquired immune deficiency syndrome (AIDS).
D000212:Acyclovir / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D003228:Conjunctiva; D003586:Cytomegalovirus Infections / Q000188:drug therapy; D005123:Eye / Q000378:metabolism*; D015774:Ganciclovir; D007267:Injections; D009994:Osmolar Concentration; D011817:Rabbits; D012173:Retinitis / Q000188:drug therapy / Q000209:etiology; D014822:Vitreous Body / Q000378:metabolism
D015774:Ganciclovir; D000212:Acyclovir