title: Human T-cell leukemia virus type II: primary structure analysis of the major internal protein, p24 and the nucleic acid binding protein, p15.
abstract: The 24,000-molecular-weight major internal protein (p24) and the 15,000-molecular-weight nucleic acid binding protein (p15) of human T-cell leukemia virus type II (HTLV-II) were subjected to amino acid composition and amino-terminal amino acid sequence analysis. A comparison of amino acid composition of p24 and p15 of HTLV-II with those of the analogous proteins of HTLV-I revealed that these two proteins share overall similarity. Further, alignment of the amino-terminal amino acid sequence for the first 27 residues of p24 and 34 residues of p15 from HTLV-II showed extensive sequence homology with analogous proteins of HTLV-I. These data suggest that although disease associated with HTLV-I is malignant T-cell leukemia and that associated with HTLV-II is a relatively benign variant of hairy-cell leukemia, HTLV-I and HTLV-II are closely related to each other, at least in their gag-gene-encoded sequences.
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D017977:Deltaretrovirus / Q000032:analysis* / Q000235:genetics; D015683:Gene Products, gag; D014644:Genetic Variation; D008970:Molecular Weight; D012191:Retroviridae Proteins / Q000302:isolation & purification*; D015682:Retroviridae Proteins, Oncogenic; D013045:Species Specificity
chemical_list: D000596:Amino Acids; D015683:Gene Products, gag; D012191:Retroviridae Proteins; D015682:Retroviridae Proteins, Oncogenic; C047061:internal protein p24, Human T-lymphotropic virus 2; C039467:virus structural protein p15