title: Specific epidermal growth factor receptors on porcine and human thyroid membranes.
abstract: Specific, high affinity, saturable receptors for epidermal growth factor (EGF) have been demonstrated both on porcine and on human thyroid membranes. The binding affinities of porcine (Ka 3.0 X 10(-9) M) and human thyroid EGF receptors (Ka 1.75 X 10(-9) M) are very similar. TSH does not inhibit the binding of 125I-EGF to either membrane. These results suggest the possibility that EGF may be involved in the regulation of human as well as porcine thyroid follicular cell growth and function.
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007700:Kinetics; D008566:Membranes / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013552:Swine; D013696:Temperature; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000378:metabolism
chemical_list: D007328:Insulin; D011956:Receptors, Cell Surface; D004815:Epidermal Growth Factor; D013972:Thyrotropin; D005934:Glucagon; D066246:ErbB Receptors