[Value of chlormethine in children with corticoid-dependent or partially corticoid-sensitive nephrosis, in steroid poisoning].
Mechlorethamine was administered at a low dose (0.8 mg/kg) to 27 children presenting with steroid dependent or partially responsive nephrotic syndrome, with signs of steroid toxicity. This drug induced a fast decrease of proteinuria (average delay: 7 days). It led to long lasting remission (average follow-up 34 months) in 16 cases (59%). Relapse occurred in 11 children (41%) most often (9 of 11 cases) in the first 7 months. However the evolutive pattern was clearly improved in 5 of these cases. Altogether, mechlorethamine allowed to stop corticosteroid therapy or, at least, to reduce the given dose, with a decrease of the signs of steroid toxicity, in 78% of the cases. In 6 cases (22%) evolution was almost not improved. One may hope that this dosage of mechlorethamine will not be gonadotoxic. This should be checked later on.
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000506:poisoning* / Q000627:therapeutic use; D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008466:Mechlorethamine / Q000627:therapeutic use*; D008775:Methylprednisolone / Q000627:therapeutic use; D009401:Nephrosis / Q000188:drug therapy*; D011241:Prednisone / Q000627:therapeutic use; D012008:Recurrence; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D008466:Mechlorethamine; D000324:Adrenocorticotropic Hormone; D011241:Prednisone; D008775:Methylprednisolone
Intérêt de la chlorméthine chez les enfants atteints de néphrose corticodépendante ou partiellement corticosensible, en intoxication stéroïdienne.