Histamine H2 receptor activity and histamine metabolism in human U-937 monocyte-like cells and human peripheral monocytes.
Functional and specific histamine H2 receptors were characterized in human peripheral monocytes and in U-937 cells, before and after retinoic acid--induced differentiation into monocyte/macrophage-like cells. The relative potencies of histamine and the H1, H2 receptor agonists and antagonists studied are remarkably similar in U-937 cells and U-937 monocytes. There is no change in histamine concentration and activity of the enzymes forming and degrading histamine during monocytic-like differentiation. The results raise the possibility that histamine H2 receptors might be involved in pathophysiological regulations (proliferation/differentiation and biological function) of normal and leukemic monocytes.
D000328:Adult; D002454:Cell Differentiation; D002460:Cell Line; D000242:Cyclic AMP / Q000096:biosynthesis; D006632:Histamine / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000032:analysis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000032:analysis / Q000378:metabolism*; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D011968:Receptors, Histamine / Q000032:analysis*; D011970:Receptors, Histamine H2 / Q000032:analysis* / Q000187:drug effects; D014212:Tretinoin / Q000494:pharmacology
D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D014212:Tretinoin; D006632:Histamine; D000242:Cyclic AMP