title: [Inhibition of gyrase by 4-quinolones: effect on the structure of DNA].
abstract: DNA gyrase is an essential enzyme in bacterial metabolism. Its function is the introduction of negative supercoils into DNA. These favour the unwinding of certain parts of DNA und thus are likely to facilitate processes like replication and transcription. Inhibition of DNA gyrase by quinolones and possible effects on the structure of DNA are reviewed.
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D003227:Conjugation, Genetic; D004261:DNA Replication / Q000187:drug effects; D004269:DNA, Bacterial / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D010957:Plasmids; D011804:Quinolines / Q000494:pharmacology*; D059005:Topoisomerase II Inhibitors; D014158:Transcription, Genetic
chemical_list: D000890:Anti-Infective Agents; D004269:DNA, Bacterial; D011804:Quinolines; D059005:Topoisomerase II Inhibitors
vernacular_title: Hemmung der Gyrase durch 4-Chinolone: Wirkung auf die Struktur der DNA.