The heparin-binding site(s) of histidine-rich glycoprotein as suggested by sequence homology with antithrombin III.
A high degree of sequence homology has been found between the N-terminal region of histidine-rich glycoprotein (HRG) and that of antithrombin III (AT III) where the putative heparin-binding site of AT III is located. The amino acid residue at the position corresponding to Arg-47 of AT III that is essential for the heparin-binding was also arginine (Arg 23 and 78) in the homologous sequences of HRG. These observations strongly suggest that the heparin-binding sites of HRG and AT III are evolutionarily related. There was no apparent sequence similarity between the remaining about 70% portions of the two proteins.
D000595:Amino Acid Sequence; D000990:Antithrombin III / Q000378:metabolism; D004347:Drug Interactions; D006023:Glycoproteins / Q000378:metabolism*; D006493:Heparin / Q000378:metabolism*; D006801:Humans; D011506:Proteins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000032:analysis*; D000099053:Histidine-Rich Glycoprotein
D006023:Glycoproteins; D011506:Proteins; D011956:Receptors, Cell Surface; C037680:heparin receptor; D000099053:Histidine-Rich Glycoprotein; D000990:Antithrombin III; D006493:Heparin