Localization of GABAA and GABAB receptor subtypes on serotonergic neurons.
The effect of selective destruction of serotonin (5-HT)-containing neurons with 5,7-dihydroxytryptamine (5,7-DHT) on [3H] muscimol and (-)-[3H]baclofen binding was investigated in various rat brain regions. Ten days after intracerebroventricular 5,7-DHT, serotonin levels and [3H]imipramine binding were markedly decreased. 5,7-DHT reduced [3H]muscimol binding only in the mesencephalon, and (-)-[3H]baclofen binding was unmodified in all the areas considered. These results suggest that except in the mesencephalon GABA receptors may not be localized on serotonergic nerve terminals.
D015116:5,7-Dihydroxytryptamine / Q000008:administration & dosage; D000818:Animals; D001418:Baclofen / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D007099:Imipramine / Q000378:metabolism; D008297:Male; D009118:Muscimol / Q000378:metabolism; D009474:Neurons / Q000145:classification / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000032:analysis* / Q000145:classification / Q000187:drug effects; D012701:Serotonin / Q000502:physiology*; D013574:Synaptosomes / Q000378:metabolism
D011963:Receptors, GABA-A; D009118:Muscimol; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D001418:Baclofen; D007099:Imipramine