[The role of disturbed DNA synthesis in the genesis of cervical carcinomas. Results of histoautoradiographic studies].
Histoautoradiographic and histopathologic studies are presented for normal and atypical cervical squamous epithelium from biopsies in 129 women. Labelling indices were obtained using in vitro labelling of biopsy specimens with H3-thymidine. In 38 cases with normal squamous epithelium, different indices were observed depending on the indication for operation. The index for normal epithelium with nearby preneoplastic changes was 5.3 +/- 1.8; for normal epithelium of patients with other diseases (uterus myomatosus, descensus uteri) it was 2.8 +/- 1.3. The index for virus-induced koilocytic dysplasias (6.3 +/- 2.9) lay between those of mild (5.3 +/- 1.4) and moderate dysplasias (7.2 +/- 1.8) without histopathological signs of virus infection. Carcinoma-in-situ (11.7 +/- 4.0) and microcarcinomas (12.6 +/- 4.2) showed higher values. There were no significant differences between the labelling indices of the microcarcinomas and preneoplastic lesions. Early stages of tumor development may histoautoradiographically offer hints of proliferative activity. In later stages the proliferative heterogeneity of the tumors limits the interpretability of the indices. The results are discussed in light of the possible role played by papilloma virus in the genesis of cervical cancer.
D001345:Autoradiography; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000503:physiopathology; D002472:Cell Transformation, Viral; D002584:Cervix Uteri / Q000166:cytology / Q000503:physiopathology; D004273:DNA, Neoplasm / Q000502:physiology*; D004848:Epithelium / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000502:physiology; D014316:Tritium; D002583:Uterine Cervical Neoplasms / Q000209:etiology* / Q000503:physiopathology
D004273:DNA, Neoplasm; D014316:Tritium
Zur Rolle von DNA-Synthesestörungen bei der Genese des Zervixkarzinoms. Ergebnisse histoautoradiographischer Untersuchungen.