Crystals and alpha-1-antitrypsin-reactive globoid inclusions in an islet cell tumor of the pancreas.
An islet cell tumor of the pancreas with unusual light microscopic, ultrastructural, and immunocytochemical features is reported. In addition to secretory granules and positive immunostaining for pancreatic polypeptide, the tumor contained globoid intracytoplasmic inclusions by light and electron microscopy, which correlated with a positive immunoreaction for alpha-1-antitrypsin, and Reinke-like crystals.
D007516:Adenoma, Islet Cell / Q000032:analysis / Q000648:ultrastructure*; D003460:Crystallization; D003594:Cytoplasmic Granules / Q000032:analysis / Q000648:ultrastructure*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D002479:Inclusion Bodies / Q000032:analysis / Q000648:ultrastructure*; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008853:Microscopy; D008854:Microscopy, Electron; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000032:analysis / Q000473:pathology / Q000648:ultrastructure*; D010191:Pancreatic Polypeptide / Q000032:analysis; D010503:Periodic Acid-Schiff Reaction; D000515:alpha 1-Antitrypsin / Q000032:analysis*
D000515:alpha 1-Antitrypsin; D010191:Pancreatic Polypeptide