Free radical-mediated activation of hydrazine derivatives.
Hydrazines are known to undergo oxidative activation in several enzymatic systems in vitro. Free radicals or carbonium ions have been proposed as active intermediates during such activation. The toxic effects elicited by hydrazines have also been linked to free radical-mediated activation. In this report, we have reviewed the identification of organic free radicals from hydrazines by direct ESR and ESR-spin trapping.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D004912:Erythrocytes / Q000378:metabolism; D005609:Free Radicals; D006454:Hemoglobins / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects; D006735:Horseradish Peroxidase / Q000378:metabolism; D006801:Humans; D006834:Hydrazines / Q000378:metabolism*; D010084:Oxidation-Reduction; D010659:Phenylhydrazines / Q000494:pharmacology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism
D001095:Arachidonic Acids; D005609:Free Radicals; D006454:Hemoglobins; D006834:Hydrazines; D010659:Phenylhydrazines; C030299:phenylhydrazine; D016718:Arachidonic Acid; D003577:Cytochrome P-450 Enzyme System; D006735:Horseradish Peroxidase; D011451:Prostaglandin-Endoperoxide Synthases