title: Integration of bacteriophage SP24 into the chromosome of group A streptococci.
abstract: The group A streptococcal bacteriophage SP24 contains a unique phage att site and integrates into a common chromosomal locus in two unrelated group A streptococcal strains, CS24 and CS112. Southern blot analysis suggested that the terminally redundant phage DNA recombines to form the unit-length genome observed in the prophage state. Phage DNA integration appears to be required for stable lysogen formation and conversion to the M+ state; however, the precise role of the bacteriophage and the relationship of phage integration to increased M protein synthesis are unclear.
mesh_terms: D000942:Antigens, Bacterial; D001287:Attachment Sites, Microbiological; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000096:biosynthesis; D001435:Bacteriophages / Q000235:genetics*; D002352:Carrier Proteins; D002876:Chromosomes, Bacterial; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000235:genetics; D005814:Genes, Viral; D008242:Lysogeny; D011995:Recombination, Genetic; D013297:Streptococcus pyogenes / Q000235:genetics* / Q000378:metabolism
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D004279:DNA, Viral; C014689:streptococcal M protein; D004262:DNA Restriction Enzymes