Wilms' tumor detection in patients with sporadic aniridia. Successful use of ultrasound.
Eleven patients with sporadic aniridia have been followed up for periods of time ranging from eight months to ten years. The initial renal evaluation included an intravenous pyelogram and ultrasound. Ultrasound evaluation was then performed every four to six months until 8 years of age. After 8 years of age, evaluation was performed every six to 12 months. Two of 11 patients were found to have Wilms' tumors. Ultrasound was sensitive enough to find small lesions prior to extension from the kidney. Ultrasound evaluation permits early detection without repeated radiation, sedation, or contrast and offers an easy technique for follow-up of patients with sporadic aniridia who have a high likelihood of developing a Wilms' tumor.
D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000150:complications; D025063:Chromosome Disorders; D006801:Humans; D007223:Infant; D007499:Iris Diseases / Q000150:complications*; D014463:Ultrasonography; D009396:Wilms Tumor / Q000150:complications / Q000175:diagnosis* / Q000601:surgery