Protective effect of polyunsaturated fatty acid supplementation in apoferritin induced murine glomerulonephritis.
The effects of increasing two dietary polyunsaturated fatty acids, eicosapentaenoic and linoleic, on the glomerulonephritis induced by repeated injections of apoferritin in the mouse were studied. Urinary protein excretion was measured serially; serum creatinine, aortic and renal production of eicosanoids and kidney histology were measured at sacrifice at 8 weeks. Both high EPA and LA feedings were associated with lesser proteinuria, normalization of renal function and profound changes in the tissue production of prostaglandin and thromboxane, which may explain their protective effect in this model of renal disease.
D000818:Animals; D001052:Apoferritins; D003404:Creatinine / Q000097:blood; D004041:Dietary Fats / Q000494:pharmacology*; D015118:Eicosapentaenoic Acid / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D005921:Glomerulonephritis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D007105:Immune Complex Diseases / Q000139:chemically induced / Q000517:prevention & control*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology; D008297:Male; D051379:Mice; D011453:Prostaglandins / Q000096:biosynthesis; D011507:Proteinuria / Q000517:prevention & control; D013929:Thromboxane B2 / Q000096:biosynthesis
D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D011453:Prostaglandins; D013929:Thromboxane B2; D001052:Apoferritins; D019787:Linoleic Acid; D015118:Eicosapentaenoic Acid; D003404:Creatinine