Effects of the mobilization of aged tissue cadmium by chelating agents.
An examination of the kidney and liver subsequent to the mobilization of aged cadmium deposits from them by the use of both dithiocarbamates and 1,2-dimercapto-1-propranolol (BAL) was carried out. No striking permanent effects due to cadmium mobilization were noted in the kidneys or livers for most of the chelating agents used. After the mobilization of part of the cadmium burden, the remaining cadmium gives evidence of undergoing a redistribution, leading to a renewed increase in both the kidney and liver levels of this element.
D000818:Animals; D002104:Cadmium / Q000378:metabolism* / Q000633:toxicity; D002614:Chelating Agents / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004112:Dimercaprol / Q000494:pharmacology; D004050:Ditiocarb / Q000031:analogs & derivatives / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D010880:Piperidines / Q000494:pharmacology; D013012:Sorbitol / Q000031:analogs & derivatives*; D013113:Spin Labels; D013859:Thiocarbamates / Q000494:pharmacology; D013997:Time Factors
D002614:Chelating Agents; D010880:Piperidines; D013113:Spin Labels; D013859:Thiocarbamates; D002104:Cadmium; D004112:Dimercaprol; D013012:Sorbitol; C041262:N-methyl-D-glucamine dithiocarbamate; C040978:4-hydroxypiperidine-N-dithiocarboxylate; C040979:4-carboxamidopiperidine-N-dithiocarboxylate; D004050:Ditiocarb; C039353:dihydroxyethyldithiocarbamate