Pharmacology of delta-opioid receptors in the hamster vas deferens.
Electrically evoked contractions of the hamster isolated vas deferens are inhibited only by opioid drugs which have agonist activity at delta-opioid receptors. Opioids which are mu-, kappa- or sigma-selective were either inactive or were antagonists. The compound beta-funaltrexamine, which irreversibly blocks mu- and delta-opioid receptors, caused a flattening of the dose-response curve and a reduced maximum inhibition available to delta-opioid agonists. Analysis of the curves by the double-reciprocal null method enabled the affinity of these agonists at delta-opioid receptors to be calculated.
D000818:Animals; D006224:Cricetinae; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D008647:Mesocricetus; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D009294:Narcotics / Q000494:pharmacology; D011957:Receptors, Opioid / Q000502:physiology*; D017465:Receptors, Opioid, delta; D014649:Vas Deferens / Q000187:drug effects / Q000502:physiology
D009294:Narcotics; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta