Abolishment of inhibitory effects of 3'-deazaadenosine on superoxide generation of guinea pig phagocytes by pre-exposure to phorbol myristate acetate.
Superoxide generation by guinea pig macrophages and polymorphonuclear leukocytes induced by wheat germ agglutinin, immune complexes or formyl-methionyl-leucyl-phenylalanine was inhibited considerably by 3'-deazaadenosine. The pre-exposure of the 3'-dezazaadenosine-treated cells to a small amount of phorbol myristate acetate abolished the inhibitory effect of 3'-deazaadenosine on the generation of superoxide.
D000818:Animals; D000936:Antigen-Antibody Complex; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D037102:Lectins / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010586:Phagocytes / Q000187:drug effects / Q000378:metabolism*; D010704:Phorbols / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014372:Tubercidin / Q000494:pharmacology*; D014909:Wheat Germ Agglutinins
D000936:Antigen-Antibody Complex; D037102:Lectins; D010704:Phorbols; D012263:Ribonucleosides; D014909:Wheat Germ Agglutinins; C018258:3-deazaadenosine; D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine; D014372:Tubercidin; D013755:Tetradecanoylphorbol Acetate