title: [Dissolution of obstructive uric acid calculi by percutaneous nephrostomy and in situ alkalinization].
abstract: Following the introduction of one or two percutaneous nephrostomy drains, 16 obstructive uric acid calculi were treated by perfusion of excretory cavities with 14% sodium bicarbonate solution. Twelve calculi had dissolved within an average of 5 days, 1 required percutaneous lithotripsy because of incomplete dissolution and 3 were unaltered. Success of this treatment appears to be dependent on the total radiotransparency of calculi, a feature difficult to demonstrate. There were no reports of major complications. The only weakly invasive nature of alkalinization in situ makes it a method of choice to be reserved for obstructive calculi, and a therapeutic strategy is proposed.
mesh_terms: D000368:Aged; D001639:Bicarbonates / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008096:Lithotripsy; D008297:Male; D009403:Nephrostomy, Percutaneous; D010477:Perfusion; D012964:Sodium / Q000008:administration & dosage / Q000627:therapeutic use*; D017693:Sodium Bicarbonate; D014527:Uric Acid; D014545:Urinary Calculi / Q000628:therapy*
chemical_list: D001639:Bicarbonates; D014527:Uric Acid; D017693:Sodium Bicarbonate; D012964:Sodium
vernacular_title: Dissolution des calculs uriques obstructifs par néphrostomie percutanée et alcalinisation in situ.