Rhesus monkeys (Macaca mulatta) as a model for calcium pyrophosphate dihydrate crystal deposition disease.
Calcium pyrophosphate dihydrate crystal deposition disease (CPDD) was recognized in 4 of 30 free-ranging rhesus macaques. By means of tissue radiography, focal radiodensities were noted in lumbar intervertebral discs, menisci, and articular cartilage. Crystal deposits were identified as calcium pyrophosphate dihydrate (Ca2P2O7 X 2H2O) by means of X-ray diffraction. The pathogenesis of calcium pyrophosphate dihydrate arthropathy in man remains elusive. However, with the recognition of this arthritis in a well defined population of aged nonhuman primates, a model now exists to facilitate the study of this disease.
D000818:Animals; D000835:Animals, Wild; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000662:veterinary*; D002131:Calcium Pyrophosphate; D003240:Connective Tissue Diseases / Q000000981:diagnostic imaging / Q000662:veterinary*; D011756:Diphosphates; D008253:Macaca mulatta; D008992:Monkey Diseases / Q000000981:diagnostic imaging*; D011859:Radiography; D014961:X-Ray Diffraction
D011756:Diphosphates; D002131:Calcium Pyrophosphate