The phage Mu repressor c and IS30 transposase proteins are significantly related.
The IS30 transposase exhibits significant amino acid sequence homology to the phage Mu repressor c in the amino- and carboxy-terminal regions of the proteins. The conserved sequences include the proposed Mu repressor DNA binding site, which is also related to the proposed Mu and D108 transposase DNA binding sites. The carboxy-terminal homologies are characterised by two almost complete, and one partial, somewhat diverged amino acid sequence repeats. Only weak homologies to this domain are present in the Mu transposase (Mu A). Nevertheless, a clear link between an insertion sequence and a bacteriophage has been established.
D000595:Amino Acid Sequence; D003090:Coliphages; D009713:Nucleotidyltransferases; D012097:Repressor Proteins; D014157:Transcription Factors; D019895:Transposases; D014764:Viral Proteins
D012097:Repressor Proteins; D014157:Transcription Factors; D014764:Viral Proteins; D009713:Nucleotidyltransferases; D019895:Transposases