gamma-Aminobutyric acid release in the globus pallidus in vivo after a 6-hydroxydopamine lesion in the substantia nigra of the rat.
This experiment was designed to determine whether the release of gamma-aminobutyric acid (GABA) in the globus pallidus (GP) is affected by a lesion of the nigrostriatal pathway. Rats were lesioned with 6-hydroxydopamine 4 weeks prior to study of the in vivo release of GABA. A microdialysis probe was stereotaxically implanted in halothane-anesthetized animals in a vertical position on both GPs. The perfusates were analyzed for their GABA content with a high performance liquid chromatography technique. Compared to unlesioned controls, a marked decrease in the overflow of GABA was observed in the GP contralateral to the lesion, whereas the ipsilateral GP showed a slight increase. The differences between the sides were exaggerated after KCl (100 mmol) administration. The results are discussed in terms of a possible bilateral influence of dopamine terminals in the striatum on GABA transmission.
D000818:Animals; D003342:Corpus Striatum / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D005917:Globus Pallidus / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000502:physiology*; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D006892:Hydroxydopamines; D005680:gamma-Aminobutyric Acid; D016627:Oxidopamine; D004298:Dopamine