Stimulus-related difference in the formation of leukotrienes and PGD2 after immunological and non-immunological challenge of human lung parenchyma "in vitro".
The stimulation of human lung parenchymal fragments with A-23187 induces formation of leukotrienes as well as of PGD2: LTE4 is the compound found in larger amount and independently of the intensity of the stimulus the % of metabolized precursor which is converted to leukotrienes or PGD2 is remarkably similar. However, under conditions of IgE-Anti IgE challenge the predominant conversion of arachidonic acid occurs to PGD2, LTB4 is almost negligible and LTD4 and E4 together represent less than 30% of the oxidative products of arachidonic acid. Whether PGD2 and leukotrienes derive from the same or different subset of cells is unresolved.
D000906:Antibodies / Q000276:immunology; D000001:Calcimycin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D066298:In Vitro Techniques; D007975:Leukotriene B4 / Q000378:metabolism; D017999:Leukotriene E4; D008168:Lung / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D015230:Prostaglandin D2; D011457:Prostaglandins D / Q000378:metabolism*; D013189:SRS-A / Q000031:analogs & derivatives* / Q000378:metabolism
D000906:Antibodies; D011457:Prostaglandins D; D013189:SRS-A; D007975:Leukotriene B4; D007073:Immunoglobulin E; D000001:Calcimycin; D017999:Leukotriene E4; D015230:Prostaglandin D2