title: Investigations of various extracts of Morinda lucida for antimalarial actions on Plasmodium berghei berghei in mice.
abstract: Morinda lucida extracts, the stem bark, the root bark and the leaves were screened for antimalarial activity in a "4-day schizontocidal test' against a chloroquine-sensitive strain of P. berghei berghei in mice. Each extract was administered as a single daily dose on days 0, 1, 2 and 3 to mice that had received an intraperitoneal inoculum of 1 X 10(7) infected erythrocytes. Each extract produced a degree of suppression of parasitaemia. The most promising result was obtained with chromatographic fractions of the stem bark extracts, the highest dose producing 96.4% suppression of parasitaemia.
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000008:administration & dosage; D006790:Host-Parasite Interactions; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010962:Plasmodium berghei / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D002738:Chloroquine