Genetic mapping of Pim-1 putative oncogene to mouse chromosome 17.
Pim-1 is a putative oncogene activated in T-cell lymphomas induced by Moloney and AKR mink cell focus forming (MCF) viruses. We have determined the chromosomal localization of the Pim-1 gene in mice by Southern blot analysis of DNAs obtained from a panel of mouse-Chinese hamster somatic cell hybrids. The Pim-1 gene was localized on chromosome 17, a chromosome frequently aberrant in T-cell lymphomas. Two chromosomal regions, containing sequences homologous to regions within the Pim-1 locus, were localized on chromosome 6 and 16.
D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D006224:Cricetinae; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005819:Genetic Markers; D006822:Hybrid Cells; D007942:Leukemia, Experimental / Q000235:genetics; D051379:Mice; D008908:Mink Cell Focus-Inducing Viruses; D008979:Moloney murine leukemia virus; D009857:Oncogenes; D011110:Polymorphism, Genetic
D005819:Genetic Markers; D004247:DNA; D004262:DNA Restriction Enzymes