title: [In vivo and in vitro study of (N-piperidinomethyl)-2-chromanne on pre- and postsynaptic alpha-adrenoreceptors in the rat].
abstract: The alpha-adrenoceptors blocking effect of (N-piperidinomethyl)-2-chromanne was studied in vivo and in vitro in the rat. In the pithed rat, (N-piperidinomethyl)-2-chromanne (1 mg/kg i.v.) antagonized the pressor effects induced by alpha agonists. (N-piperidinomethyl)-2-chromanne competitively antagonized the pressor effects of M7 (alpha 2-agonist) and cirazoline (alpha 1-agonist). (N-piperidinomethyl)-2-chromanne antagonized the inhibitory effects of clonidine on presynaptic alpha 2-receptors in stimulated pithed rats. On the vas deferens of the rat (N-piperidinomethyl)-2-chromanne antagonized the inhibitory effects of clonidine on the twitch response produced by electrical stimulation and also the contractions induced by phenylephrine. This derivate appears to be an alpha 1 and alpha 2 blocking agent.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology; D003655:Decerebrate State; D004558:Electric Stimulation; D007093:Imidazoles / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology*; D010883:Piperoxan / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D014649:Vas Deferens / Q000187:drug effects
chemical_list: D007093:Imidazoles; D010880:Piperidines; D011942:Receptors, Adrenergic, alpha; D017981:Receptors, Neurotransmitter; C046921:(N-piperidinomethyl)-2-chroman; D010883:Piperoxan; D003000:Clonidine; C014282:cirazoline
vernacular_title: Etude in vivo et in vitro du (N-pipéridinométhyl)-2-chromanne sur les alpha-adrénocepteurs pré- et postsynaptiques du rat.