title: In-vivo labeling of (3H)D-aspartate uptake sites in monkey retina.
abstract: Following prolonged topical application of (3H)D-aspartate in vivo, selective labeling of three distinct cell classes was observed in light-microscopic radioautographs from squirrel monkey retina. Müller (glial) cell bodies and their processes were intensely and consistently labeled in all preparations. Moderately labeled perikarya were occasionally detected in the area of bipolar cells, within the inner nuclear layer. These were particularly numerous in sections from the central retina where an intense diffuse labeling of the inner plexiform layer was also prominent. Finally, moderate to dense accumulations of label were observed over the cell bodies, internal segments and fiber processes of cone photoreceptors. These results strongly suggest that cones, as well as a sub-population of bipolar cells, use glutamate and/or aspartate as neurotransmitter(s) in monkey retina.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001224:Aspartic Acid / Q000008:administration & dosage; D001345:Autoradiography; D005260:Female; D009412:Nerve Fibers / Q000378:metabolism; D010786:Photoreceptor Cells / Q000378:metabolism; D012160:Retina / Q000166:cytology / Q000378:metabolism*; D012453:Saimiri; D009435:Synaptic Transmission
chemical_list: D001224:Aspartic Acid