title: Stimulation of noradrenaline synthesis by the calcium ionophore A23187 and its modulation by presynaptic receptors.
abstract: Noradrenaline (NA) synthesis in rat hippocampal synaptosomes is increased by calcium ionophore, A23187, in the presence of calcium. Activation of presynaptic muscarinic, gamma-aminobutyric acidB (GABAB) and alpha 2-adrenergic receptors causes inhibition of the ionophore-stimulated synthesis. The results suggest that different mechanisms mediate the depression by presynaptic receptors of NA release and NA synthesis.
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D011963:Receptors, GABA-A / Q000502:physiology; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D011983:Receptors, Purinergic; D013574:Synaptosomes / Q000378:metabolism
chemical_list: D011943:Receptors, Adrenergic, beta; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D017981:Receptors, Neurotransmitter; D011983:Receptors, Purinergic; D000001:Calcimycin; D000243:Adenosine Deaminase; D009638:Norepinephrine