title: Effect of dibutyryl cyclic adenosine monophosphate on canine pelviureteral discharge potentials.
abstract: An electromyographic study of the responses of the pelviureter to dibutyryl cyclic AMP was performed using isolated canine pelviureteral preparations. Dibutyryl cyclic AMP caused a marked increase in the amplitude of discharge potential in the pelvicalyceal pacemaker region and this was associated with a decrease in renal pelvic pressure. The frequency of the pacemaker discharge did not increase. On the other hand, in the lower pelvis and ureter, dibutyryl cyclic AMP caused a small but significant decrease in the amplitude of discharge potentials and this was associated with a marked decrease in discharge frequencies in the lower pelvis and ureter.
mesh_terms: D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D014513:Ureter / Q000187:drug effects*; D014563:Urodynamics / Q000187:drug effects
chemical_list: D003994:Bucladesine