The effect of chronic physical exercise on the activity of hydrolytic enzymes in acute poisoning with parathion-methyl in rats.
Parathion-methyl, 10 mg/kg p.o., was given to unexercised rats, rats trained for 3 weeks and resting for 2 days, and trained rats subjected to a single physical exercise before treatment. The activity of cholinesterase (ChE) in the serum, of paraoxonase--in the serum and liver, and of beta-glucuronidase (beta-gluc)--in the serum, liver and intestine were determined 1 h after the treatment. Repeated physical exercise increased beta-gluc activity in the serum and liver and inhibited it in the intestine, while a single race after repeated exercise inhibited paraoxonase activity in the serum. Parathion-methyl inhibited ChE and paraoxonase activities and an increased beta-gluc activity in the serum. Repeated physical exercise and a single race, applied 2 days after the end of training, affects the activity of parathion-methyl in a significant yet diversified manner, dependent upon the examined biochemical parameters.
D000818:Animals; D043303:Aryldialkylphosphatase; D002802:Cholinesterases / Q000097:blood; D004798:Enzymes / Q000378:metabolism*; D005966:Glucuronidase / Q000097:blood / Q000378:metabolism; D007422:Intestines / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D008743:Methyl Parathion / Q000506:poisoning*; D010278:Parathion / Q000031:analogs & derivatives*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains
D004798:Enzymes; D008743:Methyl Parathion; D010278:Parathion; D002802:Cholinesterases; D010744:Phosphoric Monoester Hydrolases; D043303:Aryldialkylphosphatase; D005966:Glucuronidase