Early decrease in suture line breaking strength. The effect of proposed collagenase inhibition.
Rats were subjected to end-to-end intestinal anastomosis. Breaking strength with the sutures in place, i.e., suture-holding capacity, was measured in different groups immediately after suture and after 24 h. The synthetic kallikrein-plasmin inhibitor S-2441, the inhibitor of plasminogen activation tranexamic acid (Cyklokapron), and the metalloprotease inhibitor tiopronin (Thiola), were studied regarding their effect on breaking strength of the intestinal anastomoses. There was a marked decrease in breaking strength at 24 h in the controls. This decrease was diminished by all of the substances tested. Their effect was probably due to an inhibition of collagenase.
D000818:Animals; D008297:Male; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors*; D009842:Oligopeptides / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013537:Sutures; D013718:Tensile Strength / Q000187:drug effects*; D013997:Time Factors; D008625:Tiopronin / Q000494:pharmacology; D014148:Tranexamic Acid / Q000494:pharmacology
D009842:Oligopeptides; D014148:Tranexamic Acid; C041399:prolyl-phenylalanyl-N-heptylargininamide; D008625:Tiopronin; D003012:Microbial Collagenase