Evaluation of terminal deoxynucleotidyl transferase expression in bone marrow of clinically normal and feline leukemia virus-exposed cats.
Bone marrow cells from 8 specific-pathogen-free and 11 feline leukemia virus-exposed cats were examined for the expression of the nuclear antigen terminal deoxynucleotidyl transferase (TdT). Using a standard indirect immunofluorescence technique, feline leukemia-exposed cats had increased expression of TdT in bone marrow aspirates (2.0% to 29.0%) when compared with that in bone marrow cells from specific-pathogen-free cats (2.5% to 6.0%). Seemingly, TdT can be used as an antigenic marker in leukemogenesis of FeLV-infected cats.
D000818:Animals; D001853:Bone Marrow / Q000201:enzymology* / Q000473:pathology; D002415:Cats; D004253:DNA Nucleotidylexotransferase / Q000378:metabolism*; D004254:DNA Nucleotidyltransferases / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D005256:Leukemia Virus, Feline; D007942:Leukemia, Experimental / Q000201:enzymology* / Q000382:microbiology / Q000473:pathology; D012016:Reference Values; D013047:Specific Pathogen-Free Organisms
D004254:DNA Nucleotidyltransferases; D004253:DNA Nucleotidylexotransferase