In-vitro activity of cefoperazone-sulbactam against Bacteroides species.
The in-vitro activity of two combinations of sulbactam and cefoperazone against 187 strains of Bacteroides fragilis were evaluated; their activity was compared with that of the drugs alone, and correlated with the production of beta-lactamase by the bacterial strains. The results indicated that both combinations had a synergistic effect: the addition of 8 mg/l of sulbactam to the MIC of cefoperazone reduced the percentage of resistant strains from 58% to 0.5%; while the combination of two parts of cefoperazone to one pact of sulbactam lowered the resistance rate to 1%. Synergy was observed most frequently with beta-lactamase positive strains, but it also occurred among beta-lactamase negative strains.
D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001439:Bacteroides / Q000187:drug effects* / Q000201:enzymology; D002438:Cefoperazone / Q000494:pharmacology*; D004347:Drug Interactions; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000494:pharmacology*; D013407:Sulbactam; D001618:beta-Lactamases / Q000378:metabolism
D002438:Cefoperazone; D010397:Penicillanic Acid; D001618:beta-Lactamases; D013407:Sulbactam