title: Repeated DNA sequences in the distal long arm of the human X chromosome.
abstract: Two DNA probes from within a single large insert from a recombinant phage-DNA library that was constructed from flow-sorted chromosomes enriched for the human X chromosome were shown to hybridize with repeated X-specific and autosomal DNA sequences. The X-chromosomal repeated sequences were assigned to the distal long arm of the X chromosome by both hybrid mapping and in situ hybridization. Fine mapping places these repeats in a region of Xq28 between DX13 (DXS15, in distal Xq28) and factor VIII (F8C, in proximal Xq28). The location of the X-specific repeats makes them potentially useful for future investigations of diseases mapping to the distal long arm of the X chromosome, such as the fragile X syndrome.
mesh_terms: D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D015247:Deoxyribonuclease HindIII; D006801:Humans; D006822:Hybrid Cells; D009693:Nucleic Acid Hybridization; D012091:Repetitive Sequences, Nucleic Acid; D014960:X Chromosome
chemical_list: D004247:DNA; D004262:DNA Restriction Enzymes; D015247:Deoxyribonuclease HindIII