[New directions for the use of monoclonal antibodies in leukemia diagnosis and therapy].
It has been just a decade since the advent of hybridoma technology, which has made it possible to obtain monoclonal antibodies using the method of Köhler and Milstein. The basic utilization and clinical application of monoclonal antibodies have been developed and generalized in leukemia and lymphoma. In addition, new exciting and specific approaches based on current knowledge of molecular biological techniques have been introduced, together with use of monoclonal antibodies. This paper introduces the following recent topics. Standardization of monoclonal antibodies detecting differentiation antigens. Chromosomal assignment of cell surface antigens. Immunoglobulin and T cell receptor genes as tumor markers. Autologous bone marrow transplantation with the use of antibodytoxin conjugates. Mouse-human chimeric monoclonal antibody.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000032:analysis; D016026:Bone Marrow Transplantation; D004247:DNA / Q000235:genetics; D006801:Humans; D007116:Immunization, Passive; D007938:Leukemia / Q000175:diagnosis* / Q000628:therapy; D008214:Lymphocytes / Q000145:classification; D012326:RNA Splicing; D011956:Receptors, Cell Surface / Q000235:genetics
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D011956:Receptors, Cell Surface; D004247:DNA