[Evolutionary variants of the mos gene].
The occurence of members of mos oncogene family in the vertebrates genome has been studied with the help of highly labeled single-stranded DNA probes. These included subgenic v-mos clones as well as the unique sequence--specific recombinants from mos-related human locus gp5 and the K51 locus from rat genome. The probe from gp5 (mos pseudogene) interacts only with DNA of primates and of rodents. On the other hand, mos gene and the gene from K51 locus are present in all vertberates tested. Recent duplication of the main mos gene in Artiodactyla and Perissodactyla orders of mammals was identified. The persistence of K51 and mos genes during evolution indicates their importance. The segregation of three mos-related genes in human-hamster hybrids points to their location on different human chromosomes.
D000818:Animals; D005075:Biological Evolution; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes; D013045:Species Specificity
D005819:Genetic Markers; D004262:DNA Restriction Enzymes
Evoliutsionnye varianty gena mos.