Polyneuropathy in paraproteinaemia.
Paraproteinaemias are frequently associated with peripheral neuropathies. "Benign" paraproteinaemia, myeloma and Waldenströms macroglobulinaemia may present clinically as polyneuropathy. Therefore immunoelectrophoresis is strongly recommended in the routine diagnosis of polyneuropathies of unknown origin. Peripheral neuropathies associated with paraproteinaemia are clinically, electrophysiologically, pathologically and probably also pathogenetically heterogeneous. There are subgroups such as demyelinating neuropathy associated with IgM paraproteinaemia, which show quite distinctive features. This survey describes the different types of paraproteinaemia and their associated peripheral neuropathies. The incidence, pathogenesis and therapy of peripheral neuropathy associated with monoclonal gammopathies are discussed.
D000368:Aged; D001809:Blood Viscosity; D003449:Cryoglobulinemia / Q000150:complications; D004594:Electrophysiology; D006801:Humans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications; D009101:Multiple Myeloma / Q000150:complications; D010265:Paraproteinemias / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D008258:Waldenstrom Macroglobulinemia / Q000150:complications
D007074:Immunoglobulin G; D007075:Immunoglobulin M