title: [Biochemical aspects of the action of local anesthetics].
abstract: Notions on the molecular mechanisms of anesthesia are presented. The chemical characteristics are given for main representatives of certain groups of local anesthetics with peculiarities of their membrane-tropic action mentioned. The effect of local anesthetics on the synaptic transmission, membrane enzymes, ion transport through the cell membranes is considered simultaneously with the anesthesia phenomenon on the basis of the data available in literature and results of the authors' investigations.
mesh_terms: D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000201:enzymology; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D005456:Fluorescent Dyes; D006801:Humans; D066298:In Vitro Techniques; D008563:Membrane Lipids / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D008968:Molecular Conformation; D000644:Quaternary Ammonium Compounds / Q000378:metabolism / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship
chemical_list: D000779:Anesthetics, Local; D005456:Fluorescent Dyes; D008563:Membrane Lipids; D008565:Membrane Proteins; D000644:Quaternary Ammonium Compounds; D011950:Receptors, Cholinergic; C004921:Ethonium; D000254:Sodium-Potassium-Exchanging ATPase
vernacular_title: Biokhimicheskie aspekty deĭstviia mestnykh anestetikov.