title: Kinetic alterations of cytochrome-c oxidase in cystic fibrosis.
abstract: We compared the kinetics of cytochrome-c oxidase (cytochrome-c:oxygen oxidoreductase, EC 1.9.3.1) in fibroblasts derived from normal and cystic fibrosis individuals. The Km of the enzyme for reduced cytochrome c was significantly increased in CF cells; the change, however, was observed only at temperatures above 25 degrees C. The Vmax values were comparable in both types of individuals.
mesh_terms: D002478:Cells, Cultured; D003550:Cystic Fibrosis / Q000201:enzymology*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D005347:Fibroblasts / Q000201:enzymology; D006801:Humans; D007700:Kinetics; D012016:Reference Values; D012867:Skin / Q000201:enzymology*; D013816:Thermodynamics
chemical_list: D003576:Electron Transport Complex IV