title: [Isolation and use of a farm-specific hyperimmune serum against transmissible gastroenteritis].
abstract: A specific stationary hyperimmune serum was obtained in a pigbreeding complex with a transmissive gastroenteritis infection via trifold (at a fourteen-day interval) i/m injection of sows with 5 cm3 each of undiluted virus (10(6) TCCPE50 per cm3). Tested were hyperimmunization programmes with pigs in the final fattening period. It was found that the use of undiluted virus led to the equation of sows in terms of their immunologic state and to the essential rise of the titer of humoral antibodies. In order to obtain high titer immune serum against transmissive gastroenteritis it is sufficient to proceed with the i/m injection of pigs or adult swine in the final stage of fattening at rising amounts (from 3 to 10 cm3) of attenuated virus of sufficiently high titer (10(6) TCCPE50 per cu. cm). The hyperimmune serum produced a very good prophylactic effect with newborn pigs on the same farm - the twofold oral administration of 5 to 10 cm3 on the day of birth and a couple of days later led to a drop of both morbidity and mortality rate as well as to the improvement of body development.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D002031:Bulgaria; D005260:Female; D005761:Gastroenteritis, Transmissible, of Swine / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D007106:Immune Sera / Q000302:isolation & purification*; D007116:Immunization, Passive / Q000662:veterinary*; D013552:Swine; D005760:Transmissible gastroenteritis virus / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007106:Immune Sera
vernacular_title: Poluchavane i prilagane na obornospetsifichen khiperimunen serum sreshtu transmisiven gastroenterit.