title: [In vitro effectiveness of new antiviral substances. 1. Results of screening studies against selected picornaviruses].
abstract: A number of 3108 new synthetic compounds were subjected to a screening for antiviral activity. The screening resulted in the selection of numerous drugs active against mengovirus in vitro. Some drugs were also active against Coxsackie viruses A9 and B1; most of the drugs efficient against Coxsackie virus A9 also showed activity against mengovirus. Quantitative investigations--such as the determination of a therapeutic index or of the inhibition of infectious virus yields in one-step growth cycle experiments--allowed the selection of the compounds with the highest in vitro efficacy.
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004770:Enterovirus / Q000187:drug effects; D008574:Mengovirus / Q000187:drug effects; D008826:Microbial Sensitivity Tests / Q000379:methods; D010849:Picornaviridae / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents
vernacular_title: Uber die In-vitro-Wirksamkeit neuer antiviraler Substanzen. 1. Mitteilung. Ergebnisse von Screeninguntersuchungen gegenüber ausgewählten Picornaviren.