title: The structural gene for aldolase B (ALDB) maps to 9q13----32.
abstract: We used a cloned cDNA probe for the B subunit of human aldolase (ALDB) and Southern blotting techniques to analyse DNA from a series of rodent X human somatic cell hybrids for the presence of specific ALDB-related sequences. Our results provide evidence for the assignment of the gene for ALDB to chromosome 9. Moreover, by direct gene dosage determination in two patients with chromosome 9 unbalanced rearrangements and by in situ hybridization we refined the regional chromosomal assignment to 9q13----q32 and most probably to 9q21.3----9q22.2.
mesh_terms: D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D004587:Electrophoresis, Agar Gel; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000235:genetics*; D005796:Genes; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D007223:Infant; D008297:Male; D009693:Nucleic Acid Hybridization
chemical_list: D005819:Genetic Markers; D004247:DNA; D004262:DNA Restriction Enzymes; D005634:Fructose-Bisphosphate Aldolase