Effects of prior anaesthesia on autotomy following sciatic transection in rats.
The animal model for chronic pain following sciatic nerve section in the rat has been studied varying the sensory afferents prior to nerve section, using the anaesthetic blocking of the sciatic nerve. The experimental parameters used were the day of onset of autotomy and the time course of autotomy. The results show that the anaesthetic blocking prior to nerve section significantly reduces the degree of autotomy.
D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000772:Anesthesia, Local; D000818:Animals; D008297:Male; D008619:Mepivacaine; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
D008619:Mepivacaine