Parathion-methyl effect on the activity of hydrolytic enzymes after single physical exercise in rats.
Rats were subjected to physical exercise in the form of a single race in a treadmill. Unexercised animals and those immediately or 1 h after the exercise were given oil or oily solution of parathion-methyl in a dose of 10 mg/kg by stomach gauge. At 1 h after pesticide administration the activity of cholinesterase (ChE) was determined in the serum, of paraoxonase--in the serum and liver, and that of beta-glucuronidase (beta-gluc)--in the serum, liver and intestine. Single physical exercise increased ChE activity in the serum, inhibited paraoxonase activity in the serum and liver; on the other hand, it did not affect significantly beta-gluc activity in the serum, but inhibited that enzyme in a transient manner in the liver and activated it in the intestine. In acute poisoning with parathion-methyl it was observed that ChE and paraoxonase activities were inhibited, while beta-gluc activity was enhanced in the serum. Single physical exercise either diminished or had no effect on enzymatic changes observed in acute poisoning with parathion-methyl.
D000818:Animals; D043303:Aryldialkylphosphatase; D002800:Cholinesterase Inhibitors; D002802:Cholinesterases / Q000097:blood; D004798:Enzymes / Q000378:metabolism*; D005966:Glucuronidase / Q000097:blood / Q000378:metabolism; D008658:Inactivation, Metabolic; D007422:Intestines / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D008743:Methyl Parathion / Q000378:metabolism / Q000633:toxicity*; D010278:Parathion / Q000031:analogs & derivatives*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D004798:Enzymes; D008743:Methyl Parathion; D010278:Parathion; D002802:Cholinesterases; D010744:Phosphoric Monoester Hydrolases; D043303:Aryldialkylphosphatase; D005966:Glucuronidase