title: Antinociceptive activity of beta-adrenoceptor agonists in the hot plate test in mice.
abstract: Clenbuterol, isoproterenol and salbutamol increased the latency in the licking response of mice on the hot plate at 56.5 degrees C. This effect was dose-related and obtained after IP administration. Clenbuterol was active at lower doses than isoproterenol and salbutamol, a result which is consistent with its better penetration in the central nervous system. Moreover, the effect of clenbuterol was stereospecific, the (-)-isomer being the active form. Our results suggest the implication of central beta-adrenoceptors in the modulation of the response to a painful stimulation.
mesh_terms: D000420:Albuterol; D000818:Animals; D002490:Central Nervous System / Q000503:physiopathology*; D002976:Clenbuterol; D007545:Isoproterenol; D008297:Male; D051379:Mice; D010146:Pain / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D013237:Stereoisomerism
chemical_list: D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol; D000420:Albuterol; D002976:Clenbuterol