[Monkey B-lymphocyte subpopulations transformed by baboon herpes virus in vivo and in tissue cultures].
Baboon herpes virus (BHV) similarly to human Epstein-Barr virus shows tropism to B cell subpopulation. In lymphoblastoid cultures transformed in vitro by BHV no E-RFC (T cells) are found but there are B cells with surface and cytoplasmic immunoglobulins. In a number of cultures IgM could be detected only in the cell cytoplasm. E-RFC are detectable in cultures in early passages but not after 17 passages which may be due to their elimination. The time course of cell-mediated immunity values was studied in Macaca arctoides monkeys inoculated with BHV. An increase in the relative and absolute number of B cells with surface IgM and IgG in the peripheral blood was noted. Two months after inoculation the values returned to the initial level. The number of E-RFC did not change. Changes in the number of B cells may be associated with the development of immune response, or BHV influence on the process of B cell circulation in the host.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000648:ultrastructure; D002460:Cell Line; D002472:Cell Transformation, Viral; D003593:Cytoplasm / Q000276:immunology; D006564:Herpesviridae / Q000276:immunology*; D006566:Herpesviridae Infections / Q000276:immunology* / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008251:Macaca; D010215:Papio; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012397:Rosette Formation; D014776:Virus Cultivation
D007136:Immunoglobulins; D011947:Receptors, Antigen, B-Cell
Izuchenie subpopuliatsiĭ B-limfotsitov obez'ian, transformirovannykh virusom gerpesa pavianov in vivo i v tkanevykh kul'turakh.