Hyperprolactinemia in nonpregnant women due to pituitary tumors.
The human prolactin molecule has been isolated and its structure characterized. This anterior pituitary hormone plays an important function in the induction and maintenance of lactation in the post-partum nursing mother. Prolactin-producing tumors cause inappropriate lactation in the nonpregnant woman. Bromocriptine, an ergot derivative, mimics the action of dopamine in the anterior pituitary gland and does not cure the underlying pathology. Prior to the development of bromocriptine, there was no effective treatment for the symptoms of amenorrhea and galactorrhea. Although the methods of therapy are more sophisticated today, there remain a number of unanswered questions. The unknown long-term risks of bromocriptine therapy must be balanced against the potential risk of osteopenia.
D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D000568:Amenorrhea / Q000188:drug therapy / Q000209:etiology; D000818:Animals; D001847:Bone Diseases / Q000139:chemically induced; D001971:Bromocriptine / Q000009:adverse effects / Q000627:therapeutic use; D002940:Circadian Rhythm; D004298:Dopamine / Q000502:physiology; D004967:Estrogens / Q000502:physiology; D005260:Female; D005687:Galactorrhea / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D006966:Hyperprolactinemia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D007247:Infertility, Female / Q000209:etiology; D007774:Lactation; D010053:Ovary / Q000502:physiology; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D011247:Pregnancy; D011388:Prolactin / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D011954:Receptors, Dopamine / Q000502:physiology; D011981:Receptors, Prolactin; D013973:Thyrotropin-Releasing Hormone / Q000502:physiology
D004967:Estrogens; D011956:Receptors, Cell Surface; D011954:Receptors, Dopamine; D011981:Receptors, Prolactin; D001971:Bromocriptine; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D004298:Dopamine