title: Intracerebroventricular injection of anti-prolactin serum suppresses excessive grooming of pituitary homografted rats.
abstract: Rats with endogenous hyperprolactinaemia, as induced by pituitary homografts under the kidney capsule, displayed increased grooming behavior as compared to that of sham-operated animals. Twelve days after surgery, intracerebroventricular injection of anti-prolactin serum (dilution 1:100, 1 microliter) suppressed the excessive grooming of homografted rats. These observations suggest that prolactin from a peripheral source may reach the central nervous system to affect brain mechanisms involved in grooming behavior.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000502:physiology*; D004723:Endorphins / Q000494:pharmacology; D006120:Grooming / Q000187:drug effects / Q000502:physiology*; D007106:Immune Sera / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D010902:Pituitary Gland / Q000637:transplantation*; D011388:Prolactin / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin
chemical_list: D004723:Endorphins; D007106:Immune Sera; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D011388:Prolactin