Novel analgesic peptides.
Several different classes of peptides have been found to confer antinociception upon treated animals. The now-classical enkephalins, endorphins and dynorphin have been much studied. This paper reviews enkephalins of atypical structure as well as a group of peptides which evoke antinociception apparently by stimulating release of opioid peptides. Among the latter are kyotorphin, substance P, bradykinin and neurotensin.
D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000700:Analgesics; D000818:Animals; D004745:Enkephalins / Q000494:pharmacology / Q000502:physiology*; D009020:Morphine; D013329:Structure-Activity Relationship
D000700:Analgesics; D004745:Enkephalins; D009020:Morphine; D000324:Adrenocorticotropic Hormone