Effect of beta-propiolactone on blood group antibody detection.
A panel of 50 blood group antibodies covering a range of blood group antigens has been tested in the presence of 0.25% beta-propiolactone as a possible means of reducing infectivity of high-risk HTLV III/HBsAg samples. 11/50 (22%) antibodies could not be detected by the indirect antiglobulin test, and 6/40 (15%) were undetectable by the two-stage papain technique.
D001789:Blood Group Antigens / Q000276:immunology*; D003298:Coombs Test; D017977:Deltaretrovirus / Q000302:isolation & purification; D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D007783:Lactones; D010206:Papain; D011420:Propiolactone
D001789:Blood Group Antigens; D006514:Hepatitis B Surface Antigens; D007518:Isoantibodies; D007783:Lactones; D011420:Propiolactone; D010206:Papain