Glycogenolytic effect of cortisol previous to its interaction with the cell nucleus in mouse liver.
Activities of hepatic glycogen synthase a and glycogen phosphorylase a have been studied in mouse liver at different times after an acute intraperitoneal administration of hydrocortisone. It has been observed an increase of glycogen synthase a activity and a decrease of glycogen phosphorylase a between 2 and 3.5 hours after cortisol injection. An early effect, previous to the synthase activation has been discovered. Cortisol caused an increase of glycogen phosphorylase a activity in mice 45 min after injection. This early effect of cortisol is independent of protein synthesis and it does not imply an increase in cAMP levels.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002467:Cell Nucleus / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D006006:Glycogen Synthase / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D051379:Mice; D006005:Phosphorylases / Q000378:metabolism
D008112:Liver Glycogen; D000242:Cyclic AMP; D006005:Phosphorylases; D006006:Glycogen Synthase; D002118:Calcium; D006854:Hydrocortisone