Antitumor effect of gamma-linolenic acid on cultured human neuroblastoma cells.
gamma-linolenic acid (GLA) was found to suppress the cell growth of 4 human neuroblastoma cell lines. GOTO was the most sensitive, followed by SK-N-DZ and NKP, while NCG was much less sensitive to GLA. In terms of GLA cytotoxicity, neither cyclo-oxygenase inhibitors nor a lipoxygenase inhibitor showed any effect. On the other hand, 4 antioxidants (Coenzyme Q, (D) alpha-tocopherol, (DL) alpha-tocopherol, butylated hydroxytoluene) reduced the growth inhibitory effect of GLA, but not in proportion to the decrease of GLA-stimulated lipid peroxidation. Accordingly, prostaglandins and leukotrienes probably do not play a role, and lipid peroxide may only be partly involved in the GLA effect.
D000970:Antineoplastic Agents; D000975:Antioxidants / Q000494:pharmacology; D002460:Cell Line; D016861:Cyclooxygenase Inhibitors; D006801:Humans; D008042:Linolenic Acids / Q000494:pharmacology* / Q000633:toxicity; D008054:Lipid Peroxides / Q000378:metabolism; D016859:Lipoxygenase Inhibitors; D009447:Neuroblastoma / Q000188:drug therapy*; D014451:Ubiquinone / Q000494:pharmacology; D017965:gamma-Linolenic Acid
D000970:Antineoplastic Agents; D000975:Antioxidants; D016861:Cyclooxygenase Inhibitors; D008042:Linolenic Acids; D008054:Lipid Peroxides; D016859:Lipoxygenase Inhibitors; D014451:Ubiquinone; D017965:gamma-Linolenic Acid