The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene.
We have isolated a unique fragment of the HLA-DR alpha gene and probed human genomic DNA at low stringency to search for homologous sequences. A minimum of six non-polymorphic cross-hybridizing high molecular weight fragments were found in all DNAs examined. In order to obtain molecular clones of these cross-hybridizing fragments, we constructed lambda and cosmid libraries of human DNA and screened them at low stringency with the HLA-DR alpha gene specific subclone. We have isolated clones corresponding to each of the six fragments and, in this paper, describe those which contain the gene encoding HLA-SB(DP) alpha.
D000595:Amino Acid Sequence; D001483:Base Sequence; D005075:Biological Evolution; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D005796:Genes; D006682:HLA-DP Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D007139:Immunoglobulin epsilon-Chains / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
D006682:HLA-DP Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D007139:Immunoglobulin epsilon-Chains; D004262:DNA Restriction Enzymes