[Modification of radiosensitivity and the cyclic AMP system].
The results of the experimental papers of the Soviet and foreign investigators concerning the role of cyclic AMP in modification of radiosensitivity of biological objects and the participation of cAMP system in the realization of radioprotective effect of various radioprotectants have been summarized. The action of radioprotectors on the cAMP level in cells and tissues of organism and their effect on the proteins activity of cAMP system has been considered. Particular attention has been given to the mechanisms of the radio-protective action of catecholamines on mammalian cells in vitro. On the grounds of the authors' own and literary data has been supposed that beta-adrenergic receptors and cAMP system, coupled with them, are obligatory for the performance of the radioprotective potency of catecholamines. The methodological problems of radiobiological experiments and adequate interpretation of results in compliance with terms of biochemistry and molecular endocrinology is discussed.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000528:radiation effects; D000262:Adenylyl Cyclases / Q000378:metabolism / Q000528:radiation effects; D000527:Alprostadil / Q000378:metabolism / Q000528:radiation effects; D000818:Animals; D002395:Catecholamines / Q000378:metabolism / Q000528:radiation effects; D002478:Cells, Cultured; D006224:Cricetinae; D000242:Cyclic AMP / Q000378:metabolism / Q000528:radiation effects*; D006152:Cyclic GMP / Q000378:metabolism / Q000528:radiation effects; D004789:Enzyme Activation / Q000528:radiation effects; D006801:Humans; D007399:Interphase / Q000528:radiation effects; D051379:Mice; D010766:Phosphorylation; D011833:Radiation Injuries, Experimental / Q000378:metabolism; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents / Q000494:pharmacology; D051381:Rats; D011953:Receptors, Cyclic AMP / Q000528:radiation effects
D002395:Catecholamines; D011837:Radiation-Protective Agents; D011953:Receptors, Cyclic AMP; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000262:Adenylyl Cyclases; D000527:Alprostadil; D006152:Cyclic GMP
Modifikatsiia radiochuvstvitel'nosti i sistema tsiklicheskogo AMF.