Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA.
Transformation of murine thymocytes by radiation leukemia virus is associated with reduced expression of the class I antigens encoded in the major histocompatibility complex (MHC) and increased methylation and altered restriction enzyme patterns of MHC DNA. These changes may play a role in host susceptibility to virus-induced leukemogenesis and accord with the notion that viral genomes play a regulatory function when they integrate adjacent to histocompatibility genes.
D000818:Animals; D002472:Cell Transformation, Viral; D004262:DNA Restriction Enzymes; D005786:Gene Expression Regulation; D006183:H-2 Antigens / Q000235:genetics*; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental / Q000235:genetics* / Q000382:microbiology; D008745:Methylation; D051379:Mice; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000235:genetics; D011995:Recombination, Genetic; D013601:T-Lymphocytes / Q000502:physiology; D014158:Transcription, Genetic
D006183:H-2 Antigens; D012333:RNA, Messenger; D004262:DNA Restriction Enzymes