Expression of a truncated v-myb product in transformed chicken embryo fibroblasts.
Transformed cells have been isolated after transfection of chicken embryo fibroblasts (CEF) with the DNA of a recombinant clone (KXA 3457) in which the v-myb sequences are flanked by the two AMV-LTRs. Abnormal myb-specific RNA species and myb-related polypeptides were found to be expressed in these cells, suggesting that transformation of CEF by v-myb might require alterations of the oncogene product.
D000818:Animals; D001354:Avian Leukosis Virus / Q000235:genetics*; D009189:Avian Myeloblastosis Virus / Q000235:genetics*; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D020626:Oncogene Proteins v-myb; D012367:RNA, Viral / Q000096:biosynthesis / Q000235:genetics; D012191:Retroviridae Proteins / Q000096:biosynthesis / Q000235:genetics*; D014162:Transfection
D020626:Oncogene Proteins v-myb; D012367:RNA, Viral; D012191:Retroviridae Proteins