Humoral vasopressor agents in primary hypertension.
In essential hypertension and in the spontaneously hypertensive rat, there are indications for a yet unidentified vasopressor agent which may play an important role in pathogenesis. It has been demonstrated in the spontaneously hypertensive rat by parabiosis, cross-circulation, cross-transplantation of kidneys and by injection of hypertensive plasma fractions. In plasma from essential hypertensives, an agent sensitizing the vasculature to pressor hormones and a substance with direct vasopressor actions have been found. The relationship of the hypertensive factor to the natriuretic hormone is not clear.
D000818:Animals; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007668:Kidney / Q000503:physiopathology; D009318:Natriuresis; D045283:Natriuretic Agents / Q000502:physiology; D051381:Rats; D011918:Rats, Inbred SHR / Q000097:blood; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D014662:Vasoconstrictor Agents / Q000097:blood*
D045283:Natriuretic Agents; D014662:Vasoconstrictor Agents; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase