The effect of guar gum on the acute metabolic response to glyburide.
The effect of 5 g guar gum on the acute blood glucose, insulin and C-peptide response to 5 mg glyburide (HB 419) was investigated in 10 healthy volunteers after an overnight fast. The co-administration of guar gum significantly enhanced the insulinogenic and blood glucose lowering effect of glyburide.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002096:C-Peptide / Q000097:blood; D004043:Dietary Fiber / Q000494:pharmacology*; D005260:Female; D005685:Galactans / Q000494:pharmacology*; D005905:Glyburide / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood*; D008351:Mannans / Q000494:pharmacology*; D053149:Plant Gums
D001786:Blood Glucose; D002096:C-Peptide; D004043:Dietary Fiber; D005685:Galactans; D007328:Insulin; D008351:Mannans; D053149:Plant Gums; C007894:guar gum; D005905:Glyburide