REM sleep deprivation up-regulates adenosine A1 receptors.
Adenosine receptor binding was determined in the brains of rats deprived of rapid eye movement (REM) sleep for 48 and 96 h using [3H]L-phenylisopropyladenosine. Adenosine A1 receptors (Bmax) were significantly increased in the cortex and corpus striatum, and this increase was sleep-specific. Endogenous adenosine was assayed in microwave-fixed brain tissue and no significant changes were found in REM-deprived rats.
D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D008297:Male; D010660:Phenylisopropyladenosine; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000502:physiology*; D012892:Sleep Deprivation / Q000502:physiology*; D012895:Sleep, REM; D014316:Tritium
D011956:Receptors, Cell Surface; D014316:Tritium; D010660:Phenylisopropyladenosine; D000241:Adenosine