title: Antibodies to topoisomerase I in sera from patients with scleroderma.
abstract: In a study of sera from patients with scleroderma, it was found that Scl-70 is the abundant nuclear enzyme DNA topoisomerase I.
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D004264:DNA Topoisomerases, Type I / Q000276:immunology*; D006367:HeLa Cells; D006801:Humans; D009687:Nuclear Proteins; D009698:Nucleoproteins / Q000276:immunology; D012595:Scleroderma, Systemic / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D009687:Nuclear Proteins; D009698:Nucleoproteins; C048100:Scl 70 antigen, human; D004264:DNA Topoisomerases, Type I