[Effect of hydrocortisone on superoxide radical production by phagocytosing spleen cells].
Superoxide radical production by mouse phagocytic spleen cells was shown to be essentially increased 2 hours following intraperitoneal injection of hydrocortisone acetate at a dose of 50 mg/kg body weight. The addition of hydrocortisone to the suspension of mouse spleen cells has resulted in linear dependence of hormone concentration in the incubation medium on the maximum rate of superoxide radical production. The mechanism of hydrocortisone stimulating effect on the activity of plasma membrane-located NAD(P)H-oxidase of phagocytic cells is being discussed.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010586:Phagocytes / Q000187:drug effects* / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects*; D013154:Spleen / Q000187:drug effects* / Q000276:immunology; D013481:Superoxides / Q000378:metabolism*; D013997:Time Factors
D013481:Superoxides; C021650:hydrocortisone acetate; D006854:Hydrocortisone
Vliianie gidrokortizona na produktsiiu superoksidnogo radikala fagotsitiruiushchimi kletkami selezenki.