Occurrence of the D-1 dopamine receptor in the substantia nigra of several mammalian species: identification in binding studies using [125I]SCH 23982.
The substantia nigra of the rat brain contains a high concentration of binding sites for benzazepine antagonists of the D-1 receptor. Using [125I]SCH 23982, the properties of these binding sites are characterized and shown to resemble the D-1 dopamine receptor occurring in the caudate nucleus. Similar binding sites are identified in the substantia nigra of the cat and guinea pig.
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000031:analogs & derivatives; D000818:Animals; D001345:Autoradiography; D001552:Benzazepines / Q000031:analogs & derivatives* / Q000378:metabolism*; D002415:Cats; D002421:Caudate Nucleus / Q000032:analysis*; D006168:Guinea Pigs; D008024:Ligands; D051381:Rats; D011954:Receptors, Dopamine / Q000032:analysis*; D017447:Receptors, Dopamine D1; D011963:Receptors, GABA-A / Q000378:metabolism; D013378:Substantia Nigra / Q000032:analysis*
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D001552:Benzazepines; D008024:Ligands; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D011963:Receptors, GABA-A; C049558:8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol; C044846:SKF83566