title: The endogenous retrovirus Mtv-8 on mouse chromosome 6 maps near several kappa light chain markers.
abstract: Endogenous retroviruses are known to affect expression of cellular genes in the vicinity of their integration sites. The endogenous mouse mammary tumor provirus (Mtv-8) previously has been reported to reside on mouse chromosome 6 near the immunoglobulin kappa chain locus. Using pairs of mouse strains on the BALB/c (Mtv-8 positive) and C58 (Mtv-8 negative) backgrounds which are congenic for chromosome 6 genetic markers, we have confirmed the chromosome assignment of this provirus. Moreover, we have analyzed the N1 progeny of a (B6 X C58) X C58 backcross to determine the segregation of the Mtv-8 provirus with respect to polymorphisms in the Igk-VSer and Igk-J loci. The results with congenic and backcross mice together with results of others suggest that Mtv-8 is located approximately 0.52 cM from several closely linked kappa markers on chromosome 6.
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D005814:Genes, Viral; D005819:Genetic Markers; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic
chemical_list: D005819:Genetic Markers; D007145:Immunoglobulin kappa-Chains