title: Quantitation of phosphorus excretion in sheep by compartmental analysis.
abstract: The control of phosphorus excretion in sheep has been examined by constructing a kinetic model that contains a mechanistic set of connections between blood and gastrointestinal tract. The model was developed using experimental data from chaff-fed sheep and gives an accurate description of the absorption and excretion of phosphorus in feces and urine of the ruminating sheep. Simulation of the response to an intravenous phosphorus infusion by adding an inflow of 2 g/day of phosphorus into the compartment describing blood, predicted values for fecal output of phosphorus lower than found experimentally. However, by alteration of the parameters describing absorption or salivation, the predictions approached experimental values. Similarly simulation of the conditions existing when a liquid diet was infused directly into the abomasum, i.e., a decrease in salivation rate [L(4.1)] and dietary phosphorus entering compartment 5 (abomasum) instead of compartment 4 (rumen), gave incorrect predictions for plasma and urinary phosphorus, but when the parameter for urinary phosphorus was increased the predicted values approached experimental values. These results indicated the main control site for phosphorus excretion in the ruminating sheep was the gastrointestinal tract, whereas for the nonruminating sheep fed the liquid diet, control was exerted by the kidney. A critical factor in the induction of adaptation of phosphorus reabsorption by the kidney was the reduction in salivation, and since this response occurred independently of marked changes in the delivery of phosphorus to the kidney, a humoral factor may be involved in this communication between salivary gland and kidney.
mesh_terms: D000818:Animals; D004032:Diet; D004043:Dietary Fiber / Q000502:physiology; D005243:Feces / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000378:metabolism; D008657:Metabolic Clearance Rate; D010758:Phosphorus / Q000378:metabolism* / Q000652:urine; D012417:Rumen / Q000378:metabolism; D012463:Saliva / Q000378:metabolism; D012756:Sheep / Q000378:metabolism* / Q000652:urine; D014018:Tissue Distribution
chemical_list: D004043:Dietary Fiber; D010758:Phosphorus