title: [Mechanism of renal allograft rejection].
abstract: Renal allograft rejection, in an immunocompetent subject, résults from a cellular and humoral interaction. Lymphokines, which are immunity mediators (particularly interleukin 1 and 2, and gamma interferon) modulate these different cellular populations, among which T lymphocytes play a major role. The current knowledge of rejection mechanisms allows us to evaluate the principal targets of immunosuppressive drugs used to treat allograft rejection.
mesh_terms: D000818:Animals; D006084:Graft Rejection / Q000187:drug effects; D006649:Histocompatibility Antigens / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D008222:Lymphokines / Q000276:immunology; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
chemical_list: D006649:Histocompatibility Antigens; D007166:Immunosuppressive Agents; D008222:Lymphokines
vernacular_title: Mécanismes du rejet des allogreffes rénales.