An autoradiographic study of the intrarenal localisation and retention of cisplatin, iproplatin and paraplatin.
The intrarenal localisation of platinum following the intravenous administration of platinum-195m-labelled cisplatin, iproplatin and paraplatin was studied using autoradiography. Following injection of cisplatin, platinum was distributed throughout the kidney even up to 14 days after treatment. In the case of iproplatin and paraplatin rapid platinum clearance was noted from the glomeruli, blood vessels and renal medulla within 2 h of administration. Relative cortical and medullary platinum radionuclide concentrations for all three agents were determined by Chalkley grid analysis. This showed greater relative concentrations of platinum in the cortex at increasing times following iproplatin and paraplatin compared with cisplatin. It is suggested that the lower renal toxicity of iproplatin and paraplatin than of cisplatin may be due to reduced platinum retention within the pars recta.
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D001345:Autoradiography; D016190:Carboplatin; D002945:Cisplatin / Q000493:pharmacokinetics*; D007553:Isotope Labeling; D007668:Kidney / Q000378:metabolism*; D008297:Male; D051379:Mice; D009944:Organoplatinum Compounds / Q000493:pharmacokinetics*; D010984:Platinum; D011786:Quality Control; D011868:Radioisotopes
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D011868:Radioisotopes; D010984:Platinum; C023359:iproplatin; D016190:Carboplatin; D002945:Cisplatin