Synthesis and antiviral activity of various esters of 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine.
The synthesis and in vivo biological activity of a series of mono-O-, di-O-, and N2-acyl derivatives of 9-[(1,3-dihydro-2-propoxy)-methyl]guanine (DHPG) are described.
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004952:Esters; D015774:Ganciclovir / Q000031:analogs & derivatives*; D006561:Herpes Simplex / Q000188:drug therapy; D051379:Mice; D018139:Simplexvirus / Q000187:drug effects
D000998:Antiviral Agents; D004952:Esters; C045895:9-((2,3-dihydroxy-1-propoxy)methyl)guanine; D015774:Ganciclovir; D000212:Acyclovir