Toluene diisocyanate respiratory reactions. I. Reassessment of the problem.
A series of workers with exposure to and respiratory symptoms from toluene diisocyanate (TDI) was compared with a group of exposed, asymptomatic workers and with normal controls using immunologic and clinical evaluations. Improved understanding of TDI-induced respiratory disease may best be achieved by categorizing the symptomatic workers into at least 3 and possibly 4 groups: immunologic TDI asthma; pre-existing chronic respiratory disease exacerbated or unaffected by TDI; asthma coincidental with TDI exposure, and possibly TDI respiratory disease secondary to toxic or inflammatory mechanisms.
D000328:Adult; D001249:Asthma / Q000139:chemically induced* / Q000276:immunology; D003485:Cyanates / Q000009:adverse effects*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007536:Isomerism; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000276:immunology; D012119:Respiration / Q000187:drug effects; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects*
D003485:Cyanates; D007136:Immunoglobulins; D014051:Toluene 2,4-Diisocyanate; C026942:2,6-diisocyanatotoluene