The neurovirulence of flaviviruses in crab-eating monkeys (Macaca fascicularis).
The neurovirulent properties of attenuated dengue-2 and yellow fever (YF) vaccines, dengue-2 (DEN-2) and Japanese encephalitis (JE) viruses were studied in crab-eating monkeys (Macaca fascicularis). Number of central nervous system sites (as proportion affected) with neurovirulence (NV) lesions were compared. The results indicate that these monkeys reliably developed NV-lesion when inoculated with either JE or YF vaccine viruses (87%). NV-lesions occurred in a minority when inoculated with DEN-2 vaccine virus, were of minimal severity (9%), were probably biologically insignificant, and were of equal or less severity than lesions produced by its parental virus (10%).
D000818:Animals; D002490:Central Nervous System / Q000473:pathology; D003716:Dengue Virus / Q000276:immunology / Q000472:pathogenicity; D004664:Encephalitis Virus, Japanese / Q000276:immunology / Q000472:pathogenicity; D005260:Female; D005416:Flavivirus / Q000276:immunology* / Q000472:pathogenicity; D008251:Macaca; D008252:Macaca fascicularis; D008297:Male; D014613:Vaccines, Attenuated / Q000009:adverse effects; D014765:Viral Vaccines / Q000009:adverse effects*; D014774:Virulence; D015005:Yellow fever virus / Q000276:immunology / Q000472:pathogenicity
D014613:Vaccines, Attenuated; D014765:Viral Vaccines