Aspergillus coronary embolization causing acute myocardial infarction.
An increased frequency of disseminated aspergillosis has been observed in the last decade, mostly occurring in immunocompromised patients including the bone marrow transplant population. Cardiac involvement by Aspergillus remains rare. We report the clinical and postmortem findings of an unusual case of Aspergillus pancarditis in a 7-year-old bone marrow transplant patient with Aspergillus embolization to the coronary arteries leading to a massive acute myocardial infarction. This case suggests that myocardial injury secondary to disseminated aspergillosis should be included in the differential diagnosis of chest pain in the immunocompromised pediatric patient.
D001228:Aspergillosis / Q000150:complications* / Q000209:etiology / Q000473:pathology; D016026:Bone Marrow Transplantation; D002648:Child; D003327:Coronary Disease / Q000150:complications*; D003328:Coronary Thrombosis / Q000150:complications* / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology* / Q000473:pathology; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy