title: Molecular biology of the HLA-B27 locus.
abstract: The molecular biology of the HLA-B27 locus is reviewed. The HLA-B27 gene itself does not differ between healthy individuals and ankylosing spondylitis patients. Several unique features of the HLA-B27 molecule have been identified and one epitope was proposed to cross-react with bacterial proteins.
mesh_terms: D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D004270:DNA, Circular / Q000235:genetics; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics*; D015796:HLA-B27 Antigen; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D013167:Spondylitis, Ankylosing / Q000235:genetics
chemical_list: D004270:DNA, Circular; D006680:HLA Antigens; D015796:HLA-B27 Antigen