[2 cases of AIDS in patients with hemophilia A].
The authors report the first two cases of lethal AIDS in haemophilia A in France. One French case of AIDS in haemophilia B has already been reported. The diagnosis was based on the observation of opportunist infections associated with severe depression of cell-mediated immunity in both cases. The possibility of active transmission of the LAV retrovirus by factor VII concentrate is discussed. This raises the problem of the signification of anti-LAV antibodies in haemophiliac patients and the control of products used for the treatment of haemophilia.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000635:transmission; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D017977:Deltaretrovirus / Q000276:immunology; D006467:Hemophilia A / Q000628:therapy*; D006801:Humans; D008297:Male; D065227:Transfusion Reaction
D000914:Antibodies, Viral
Deux cas de SIDA chez des hémophiles A.