Distribution of Trop 3 and 4 antigens in human endometrial glandular epithelium.
The reactivities of three monoclonal antibodies (MAbs), Trop 3, Trop 4, and W6/32, were studied on human uterine tissue by using an indirect immunoperoxidase method. Nonpregnant endometrial glandular epithelium was stained by all three MAbs. During pregnancy, Trop 3 expression was not detectable, but Trop 4 and W6/32 showed variable staining on the endometrial glandular epithelium, especially during late pregnancy. These findings support previous work suggesting a local regulation of antigenic expression by endometrial glandular epithelial cells.
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000941:Antigens / Q000032:analysis*; D004717:Endometrium / Q000276:immunology*; D004848:Epithelium / Q000276:immunology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D010920:Placenta / Q000276:immunology; D011247:Pregnancy / Q000276:immunology*; D014327:Trophoblasts / Q000276:immunology
D000911:Antibodies, Monoclonal; D000941:Antigens