Lack of angiotensin I accumulation after converting enzyme blockade by enalapril or lisinopril in man.
In nine normal volunteers, a series of five venous blood samples was obtained before and up to 24 h after converting enzyme inhibition by a single oral dose of enalapril or lisinopril. Plasma renin activity and blood angiotensin I were measured. A close linear relationship was found between the increase in plasma renin activity and the increase in blood angiotensin I. The linear correlation between plasma renin activity and blood angiotensin I remained after converting enzyme inhibition. Thus, the rise in angiotensin I after inhibition of the conversion of angiotensin I to angiotensin II is due to an enhanced release of renin rather than to accumulation of angiotensin I.
D000328:Adult; D000803:Angiotensin I / Q000097:blood*; D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D017706:Lisinopril; D008297:Male; D012083:Renin / Q000097:blood
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril; D000803:Angiotensin I; D017706:Lisinopril; D012083:Renin