title: Haemodynamic, hormonal and urinary responses to postural change in tetraplegic and paraplegic man.
abstract: We have studied the haemodynamic, hormonal and urinary effects of postural change in 6 tetraplegic patients, 6 paraplegic patients and 6 normal subjects. Measurements of blood pressure and heart rate, plasma renin activity, plasma aldosterone, urine volume and electrolyte excretion were made for 60 minutes while sitting and 60 minutes while recumbent. In tetraplegics the blood pressure was lower when sitting and rose during recumbency, unlike paraplegics and normal subjects. Plasma renin activity and aldosterone were higher in tetraplegics when sitting compared to normal subjects and did not fall during recumbency. Urine output increased significantly after recumbency in tetraplegics, but not in paraplegics or normal subjects. Both urinary sodium and potassium excretion were lower in tetraplegics and higher in paraplegics compared to normal subjects when sitting. In paraplegics the fall in both sodium and potassium excretion did not appear to be related to change in posture. Our observations indicate that recumbency induces a diuresis in tetraplegics but not in paraplegics or in normal subjects. The diuresis in tetraplegics may be related to the accompanying haemodynamic and hormonal changes induced by recumbency.
mesh_terms: D000450:Aldosterone / Q000097:blood; D001794:Blood Pressure; D004231:Diuresis; D006439:Hemodynamics; D006728:Hormones / Q000097:blood*; D006801:Humans; D009318:Natriuresis; D010264:Paraplegia / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D011187:Posture; D011188:Potassium / Q000652:urine; D011782:Quadriplegia / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D012083:Renin / Q000097:blood
chemical_list: D006728:Hormones; D000450:Aldosterone; D012083:Renin; D011188:Potassium