title: Localization of beta-adrenergic receptors on differentiated cells of the central nervous system in culture.
abstract: Hypothalamic neurons and cortical protoplasmic (type 1) astrocytes in dissociated cultures of rat brain express binding sites for antibodies specific for epitopes related to the beta-adrenergic receptor. Undifferentiated glial progenitor cells of the rat optic nerve do not detectably bind these antibodies, but both of the progeny [oligodendroglia and process-bearing (type 2) astrocytes] express immunologically identified beta-adrenergic receptors. Levels of receptor expression are variable: not all cells of each type express receptors nor is expression uniform on a given cell. The data suggest that cells of the central nervous system express beta-adrenergic receptors but that levels of expression may be determined by the differentiated state of the cells.
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001253:Astrocytes / Q000032:analysis; D002454:Cell Differentiation; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D007031:Hypothalamus / Q000032:analysis* / Q000166:cytology; D009474:Neurons / Q000032:analysis; D009900:Optic Nerve / Q000032:analysis* / Q000166:cytology; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000032:analysis* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D011943:Receptors, Adrenergic, beta