title: Effect of adrenergic and cholinergic drugs on the noradrenergic transmission in bladder neck smooth muscle.
abstract: Strips of bladder neck smooth muscle were isolated from the dog and noradrenaline stores in the peripheral sympathetic nerve terminals were labelled with (-)3H-noradrenaline. Transmural electrical stimulation was applied and the released radiolabeled noradrenaline in the superfusate was measured with a liquid scintillation counter. Autonomic drugs were administered in the superfusate to examine their effect on noradrenaline release evoked by electrical stimulation. The general conclusions drawn from the data are that: there are two autonomic receptor systems on sympathetic nerve terminals of bladder neck--alpha-adrenergic receptors and muscarinic receptors, the activation of alpha-adrenergic receptors or muscarinic receptors depresses noradrenaline release and parasympathetic nerve excitement inhibits noradrenaline release in bladder neck.
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000502:physiology; D010277:Parasympathomimetics / Q000494:pharmacology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011976:Receptors, Muscarinic / Q000187:drug effects; D013566:Sympathomimetics / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects; D001743:Urinary Bladder / Q000294:innervation*; D014554:Urination
chemical_list: D010277:Parasympathomimetics; D011942:Receptors, Adrenergic, alpha; D011976:Receptors, Muscarinic; D013566:Sympathomimetics; D009638:Norepinephrine