[Effect of cardiac glycosides on the calcium ion binding by biomembrane lipids].
By using methods of fluorescent and spine (electron paramagnetic resonance) probes it was shown that cardiac glycosides (digoxin, digitoxin, convallatoxin, corelborine and strophanthin) effectively interact with biomembrane lipids enhancing conformational motility of lipids and cause additional binding of calcium ions with the membrane.
D002018:Bufanolides / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002301:Cardiac Glycosides / Q000494:pharmacology*; D004347:Drug Interactions; D004578:Electron Spin Resonance Spectroscopy; D066298:In Vitro Techniques; D008081:Liposomes / Q000378:metabolism; D008560:Membrane Fluidity / Q000187:drug effects; D008563:Membrane Lipids / Q000378:metabolism*; D008564:Membrane Potentials / Q000187:drug effects; D013050:Spectrometry, Fluorescence
D002018:Bufanolides; D002301:Cardiac Glycosides; D008081:Liposomes; D008563:Membrane Lipids; C007913:hellebrin; D002118:Calcium
Vliianie serdechnykh glikozidov na sviazyvanie ionov kal'tsiia lipidami biomembran.