Immunopathogenesis of canine angistrongylosis: pulmonary effects of infection.
Deposits of immunoglobulins, complement, and fibrinogen were localized in the lungs of Angiostrongylus vasorum-infected dogs. In acutely infected dogs, significant deposits of IgA, IgG and IgM, complement, and fibrinogen were seen. The predominant immunoglobulin noted in infections of longer duration was IgG. The continued presence of fibrinogen as the predominant protein deposited suggested a continuation of intravascular coagulation. This was borne out by demonstrating luminal deposits of fibrinogen in many blood vessels. Histopathologic examination of the large revealed lesions typical of angiostrongylosis, as well as eggs of the worm as early as 35 days postinfection. This is the earliest report of egg production by A. vasorum on record.
D000208:Acute Disease; D000801:Angiostrongylus / Q000276:immunology; D000818:Animals; D003176:Complement C3 / Q000032:analysis*; D004283:Dog Diseases / Q000276:immunology* / Q000473:pathology; D004285:Dogs; D005340:Fibrinogen / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D008168:Lung / Q000032:analysis / Q000469:parasitology / Q000473:pathology; D008297:Male; D009349:Nematode Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary*
D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D005340:Fibrinogen