Antiviral activity of Bordetella pertussis vaccine-elicited peritoneal exudate cells.
Peritoneal exudate cells collected from mice 7 days after treatment with Bordetella pertussis vaccine exhibited significant in vitro antiviral activity against vesicular stomatitis virus (VSV). Vaccine-induced peritoneal exudate cells exhibited both intrinsic and extrinsic antiviral activity in culture with target VSV-infected L cells. Virus replication was poor in the vaccine-induced exudate cells. Coculture of vaccine-induced exudate cells and VSV-infected L cell targets decreased virus yield. The activity appeared specific for infected cells and at least a portion of the antiviral activity was directed against the initial infection cycle. Nonadherent vaccine-induced exudate cells showed an increase in antiviral activity over total vaccine-induced exudate cells.
D000818:Animals; D007694:Killer Cells, Natural / Q000276:immunology; D007739:L Cells / Q000382:microbiology; D051379:Mice; D008809:Mice, Inbred C3H; D010529:Peritoneal Cavity / Q000166:cytology / Q000276:immunology*; D010567:Pertussis Vaccine / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development; D014779:Virus Replication
D010567:Pertussis Vaccine