Beneficial effect of prostaglandin E1 in three cases of lupus nephritis with nephrotic syndrome.
Prostaglandin E1 was intravenously injected daily for 4 weeks to three patients with lupus nephritis accompanied by severe nephrotic syndrome. Histologic examination revealed diffuse proliferative or membranous glomerulonephritis. Proteinuria decreased markedly 1 year after the treatment with improvement in hypoproteinemia in all three patients. Five years later, the conditions of three cases ameliorated further.
D000328:Adult; D000527:Alprostadil / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008181:Lupus Nephritis / Q000150:complications / Q000188:drug therapy*; D009404:Nephrotic Syndrome / Q000150:complications*; D011459:Prostaglandins E, Synthetic / Q000627:therapeutic use; D013997:Time Factors
D011459:Prostaglandins E, Synthetic; D000527:Alprostadil