Complement activation and spleen function in erythema multiforme associated with herpes simplex virus reactivation.
Plasma C3d concentrations were measured in patients with erythema multiforme (EM) complicating herpes labialis. C3d levels were raised during cold sores but not during EM. Heat damaged red cell clearance was prolonged during EM. These observations support the concept that immune complexes disseminate herpes simplex virus (HSV) antigens to skin before the onset of EM.
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000276:immunology; D003167:Complement Activation; D003176:Complement C3 / Q000032:analysis; D015933:Complement C3d; D004892:Erythema Multiforme / Q000209:etiology / Q000276:immunology*; D004912:Erythrocytes / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D008875:Middle Aged; D018139:Simplexvirus / Q000254:growth & development / Q000276:immunology*; D013154:Spleen / Q000276:immunology / Q000502:physiology*; D014775:Virus Activation
D000936:Antigen-Antibody Complex; D003176:Complement C3; D015933:Complement C3d