title: Safety of oral intake of vitamin E.
abstract: A review of the literature concerning the safety of oral intake of vitamin E indicated that the toxicity of vitamin E is low. Vitamin E supplementation has resulted in inconsistent effects in serum lipid and lipoprotein levels. Animal studies showed that vitamin E is not mutagenic, carcinogenic, or teratogenic. In human studies with double-blind protocols and in large population studies, oral vitamin E supplementation resulted in few side effects even at doses as high as 3200 mg/d (3200 IU/d).
mesh_terms: D000818:Animals; D001778:Blood Coagulation Disorders / Q000139:chemically induced / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D014810:Vitamin E / Q000008:administration & dosage / Q000009:adverse effects* / Q000633:toxicity
chemical_list: D008055:Lipids; D008074:Lipoproteins; D014810:Vitamin E