Immunoglobulin A nephropathy and ankylosing spondylitis. Report of two patients in Taiwan and review of the literature.
We describe 2 patients with immunoglobulin A (IgA) nephropathy in association with ankylosing spondylitis. Renal biopsy demonstrated mesangial proliferative glomerulonephritis with prominent IgA, C3c, and less intense properdin deposition in the glomeruli. Intraglomerular clumps of virus-like particles were also observed in the kidney sample from one patient (case 2), who had an abnormal liver function. Our findings support the hypothesis that here is a possible common pathogenesis responsible for the concurrence of both IgA nephropathy and ankylosing spondylitis.
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000453:epidemiology*; D013624:Taiwan