Mutagenic activities of selected nitrofluoranthene derivatives in Salmonella typhimurium strains TA98, TA98NR and TA98/1,8-DNP6.
The mutagenic activities of novel nitrofluoranthene derivatives in Salmonella strains TA98, TA98NR and TA98/1,8-DNP6 (with and without S9 addition) are given. These derivatives were produced from the reactions of fluoranthene (FL) and its directly mutagenic 2- and 3-nitro derivatives with covalent dinitrogen pentoxide (N2O5) in CCl4 solution at ambient temperature. The influence of the addition of a nitro group on the observed activity of the resulting di- and tri-nitrofluoranthenes is discussed.
D005449:Fluorenes / Q000138:chemical synthesis / Q000494:pharmacology*; D015394:Molecular Structure; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship
D005449:Fluorenes; D009153:Mutagens; D009574:Nitro Compounds