Cutaneous malakoplakia. Report of a case.
A case of cutaneous malakoplakia in a 44-year-old women under immunosuppressive therapy after renal transplantation for nephrosclerosis is reported. A nodular lesion with inflammatory signs appeared on her right buttock. Histopathology showed a dermal infiltrate with histiocytes containing Michaelis-Gutmann bodies. Electron microscopy showed Michaelis-Gutmann bodies with concentric laminar structure ('target' appearance). Tissue culture revealed Escherichia coli growth. Lesions recurred on surrounding skin and left buttock after excision. Clofazimine treatment resulted in total remission.
D000328:Adult; D002991:Clofazimine / Q000627:therapeutic use; D004927:Escherichia coli Infections; D005260:Female; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008287:Malacoplakia / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D012871:Skin Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*
D002991:Clofazimine