Variation in ten lysosomal hydrolase enzyme activities in inbred mouse strains.
Activities of 10 lysosomal hydrolase enzymes (beta-hexosaminidase, beta-galactosidase, alpha-galactosidase, alpha-mannosidase, beta-mannosidase, alpha-L-fucosidase, beta-glucuronidase, alpha-glucosidase, alpha-N-acetylgalactosaminidase, and acid phosphatase) were determined in eight organs (brain, liver, kidney, spleen, heart, skeletal muscle, lung, and testis) in males and females of six inbred mouse strains (C57BL/6J, C3H/HeJ, DBA/2J, BALB/cJ, P/J, and 129/J). Examples of enzyme-specific variation, organ-specific variation, and enzyme- and organ-specific variation were found. New enzyme-specific variants with the features of systemic regulators for alpha-L-fucosidase and beta-mannosidase were found. Known variants were detected. Organ-specific variants had some of the properties expected for a new class of genes affecting multiple enzymes: organ-specific regulators.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D005260:Female; D014644:Genetic Variation; D005966:Glucuronidase / Q000378:metabolism; D006596:Hexosaminidases / Q000378:metabolism; D006867:Hydrolases / Q000235:genetics* / Q000378:metabolism; D007700:Kinetics; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D008361:Mannosidases / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D012737:Sex Factors; D013045:Species Specificity; D014018:Tissue Distribution; D000519:alpha-Galactosidase / Q000378:metabolism; D005644:alpha-L-Fucosidase / Q000378:metabolism; D043323:alpha-Mannosidase; D001616:beta-Galactosidase / Q000378:metabolism; D044902:beta-Mannosidase; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism
D006867:Hydrolases; D000135:Acid Phosphatase; D006596:Hexosaminidases; D008361:Mannosidases; D000519:alpha-Galactosidase; D001616:beta-Galactosidase; D043323:alpha-Mannosidase; D044902:beta-Mannosidase; D005966:Glucuronidase; D005644:alpha-L-Fucosidase; D001619:beta-N-Acetylhexosaminidases