[Antiabstinent action of fenibut and baclofen on a model of abstinence induced by the benzodiazepine receptor antagonist CGS 8216 in rats receiving diazepam].
Benzodiazepine receptor antagonist CGS 8216 (2.5 mg/kg) induced clear-cut signs of abstinence lasting 1-1.5 hours in rats after discontinuation of diazepam treatment (10-20 mg/kg/day, 20 days). Diazepam (10-20 mg/kg) and GABAB-receptor agonists: phenibut (10-100 mg/kg) and baclofen (1.25-5.0 mg/kg) abolished the signs of abstinence. Conversely, GABAB-receptor agonist THIP enhanced the signs of abstinence. It is suggested that anti-abstinence effect of phenibut and baclofen may reflect their tranquilizing activity.
D000818:Animals; D001418:Baclofen / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D003975:Diazepam / Q000009:adverse effects*; D004353:Drug Evaluation, Preclinical; D007555:Isoxazoles / Q000494:pharmacology; D008297:Male; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome / Q000139:chemically induced / Q000188:drug therapy*; D014149:Tranquilizing Agents / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D007555:Isoxazoles; D011720:Pyrazoles; D011963:Receptors, GABA-A; D014149:Tranquilizing Agents; D005680:gamma-Aminobutyric Acid; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one; D001418:Baclofen; C015542:gaboxadol; D003975:Diazepam; C008842:4-amino-3-phenylbutyric acid
Antiabstinentnoe deĭstvie fenibuta i baklofena na modeli abstinentsii, vyzvannoĭ antagonistom benzodiapepinovykh retseptorov CGS 8216 u krys, poluchavshikh diazepam.