Plasma levels of main granulocyte components in patients dialyzed with polycarbonate and cuprophan membranes.
Plasma levels of granulocyte lactoferrin, granulocyte myeloperoxidase and granulocyte elastase in complex with alpha 1-proteinase inhibitor (E-alpha 1PI) were investigated in regular hemodialysis patients dialyzed with hollow-fiber dialyzers made from polycarbonate (FD 100) or cuprophan (GFS 120 H). Plasma levels of all these main granulocyte components increased significantly during hemodialysis. E-alpha 1PI levels were significantly higher in patients dialyzed with the polycarbonate compared with the cuprophan membrane, whereas the increases of myeloperoxidase and lactoferrin were not different for the two dialyzers. On the other hand, plasma C3a levels were higher in patients dialyzed with the cuprophan compared with the polycarbonate dialyzer. Therefore, granulocyte activation during hemodialysis does not necessarily need complement activation.
D001798:Blood Proteins; D002482:Cellulose / Q000031:analogs & derivatives*; D003176:Complement C3 / Q000032:analysis; D015926:Complement C3a; D003738:Dental Cements; D005260:Female; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D007688:Kidneys, Artificial; D007781:Lactoferrin / Q000097:blood; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000097:blood; D009195:Peroxidase / Q000097:blood; D011076:Polycarboxylate Cement; D006435:Renal Dialysis; D014511:Uremia / Q000628:therapy; D000515:alpha 1-Antitrypsin
D001798:Blood Proteins; D003176:Complement C3; D003738:Dental Cements; D008567:Membranes, Artificial; D011076:Polycarboxylate Cement; D000515:alpha 1-Antitrypsin; C005506:polycarbonate; D015926:Complement C3a; D002482:Cellulose; C009865:cuprammonium cellulose; D009195:Peroxidase; D007781:Lactoferrin; D010196:Pancreatic Elastase