title: Competitive inhibition of human skin collagenase by N-benzyloxycarbonyl-L-prolyl-L-alanyl-3-amino-2-oxopropyl-L-leucyl-L- alanylglycine ethyl ester.
abstract: A 'ketomethylene' peptide, N-benzyloxycarbonyl-L-prolyl-L-alanyl-3-amino- 2-oxopropyl-L-leucyl-L-alanylglycine ethyl ester, was synthesized and shown to be a fairly potent competitive inhibitor of human skin collagenase.
mesh_terms: D002478:Cells, Cultured; D006801:Humans; D007700:Kinetics; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D012867:Skin / Q000201:enzymology*
chemical_list: C051516:N-benzyloxycarbonyl-prolyl-alanyl-3-amino-2-oxopropyl-leucyl-alanyl-glycine ethyl ester; D009842:Oligopeptides; D003012:Microbial Collagenase