Peripheral neuropathy with gammopathy responding to plasmapheresis.
Two patients with subacute sensorimotor peripheral neuropathy were found to have benign gammopathies. They both responded to treatment by plasmapheresis. We suggest that a vigorous search for a paraprotein should be made in all undiagnosed patients presenting with peripheral neuropathy, including electrophoresis with isoelectric focusing. Plasmapheresis may be a treatment modality that should be explored in such cases.
D000368:Aged; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000628:therapy*; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D010956:Plasmapheresis; D011239:Prednisolone / Q000627:therapeutic use
D007136:Immunoglobulins; D011239:Prednisolone