Chemical and biological properties of 2,6-diisopropyl IDA labelled with 99mTc.
A procedure is described for the synthesis of 2,6-diisopropyl IDA (DISIDA) and for preparation of the radiopharmaceutical by "instant technique". The chemical parameters affecting the formation of the Sn(II)-DISIDA complex were also determined. Biological studies involved lyophylic measurements, determination of binding constants as well as rate of binding to proteins and biodistribution. Clinical investigation demonstrated good hepatobiliary features of this radiopharmaceutical.
D000328:Adult; D000818:Animals; D001659:Biliary Tract / Q000000981:diagnostic imaging; D006801:Humans; D007098:Imino Acids / Q000302:isolation & purification* / Q000378:metabolism; D008099:Liver / Q000000981:diagnostic imaging; D009942:Organometallic Compounds / Q000302:isolation & purification* / Q000378:metabolism; D011485:Protein Binding; D011877:Radionuclide Imaging; D051381:Rats; D019785:Technetium Tc 99m Disofenin; D014018:Tissue Distribution
D007098:Imino Acids; D009942:Organometallic Compounds; D019785:Technetium Tc 99m Disofenin