title: Characterization of [3H]Ro5-4864 binding to "peripheral" benzodiazepine receptors in guinea pig alveolar type II cells.
abstract: The binding of [3H]Ro5-4864 to peripheral benzodiazepine receptors has been demonstrated in a highly purified preparation of alveolar type II cells. [3H]Ro5-4864 binding to guinea pig alveolar type II cells indicated one population of binding sites with high affinity (KD = 5.7 nM) and saturability (Bmax = 4582 fmol/mg membrane protein).
mesh_terms: D000818:Animals; D001570:Benzodiazepinones / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D006168:Guinea Pigs; D008168:Lung / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D011650:Pulmonary Alveoli / Q000378:metabolism*; D011963:Receptors, GABA-A / Q000378:metabolism*
chemical_list: D001570:Benzodiazepinones; D011963:Receptors, GABA-A; C028513:4'-chlorodiazepam