Patterns of inheritance of colonic polyps.
While the inheritance pattern of familial polyposis coli is established as an autosomal dominant pattern, the expression of the various extracolonic manifestations associated with the neoplastic polyposis is less well understood. The discrete polyp cancer syndrome may not be recognized unless both polyps and colon cancer are considered in the inheritance pattern. The hamartomatous polyps follow a Mendelian-dominant inheritance pattern for the Peutz-Jeghers syndrome, while the inheritance pattern for the juvenile polyposis syndromes is less clear. Cowden's disease appears in a Mendelian dominant pattern, but the occurrence of colonic polyps is less well documented. The ganglioneuromas follow a mendelian dominant inheritance pattern, while the relationship and occurrence of colonic polyps in association with Torre's syndrome is uncertain. The Mendelian dominant inheritance pattern for the cancer family syndrome is documented; the role of colon polyps in this syndrome is less well understood. A further understanding of the inheritance patterns of these various colon polyps will lead to more understanding of the basic disease and help in prevention and early detection for treatment and cure.
D011125:Adenomatous Polyposis Coli / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics; D003111:Colonic Polyps / Q000145:classification / Q000235:genetics*; D006222:Hamartoma / Q000235:genetics; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D011230:Precancerous Conditions / Q000235:genetics