Hyperreactive malarial splenomegaly in Venezuela.
A cross-sectional seroepidemiological survey seeking hyperreactive malarial splenomegaly was carried out in isolated Yanomami hamlets in Amazonas Territory in Venezuela. All 110 inhabitants greater than 1 year of age were evaluated clinically and 98 were studied immunologically. The spleen index for individuals greater than 10 years of age was 44%. Only 3 patients had Plasmodium spp. on thick blood smears. All had serological evidence of infection with Plasmodium falciparum and P. vivax. Twenty-three patients were considered to show hyperreactive malarial splenomegaly. Clinical manifestations of the syndrome did not differ from those described in other parts of the world.
D000293:Adolescent; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008288:Malaria / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010961:Plasmodium / Q000302:isolation & purification; D010963:Plasmodium falciparum / Q000276:immunology; D010966:Plasmodium vivax / Q000276:immunology; D013163:Splenomegaly / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology; D013577:Syndrome; D014687:Venezuela
D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D007075:Immunoglobulin M