title: Genetic studies of low abundance human plasma proteins. III. Polymorphism of the C1R subcomponent of the first complement component.
abstract: Genetic polymorphism of the C1R subcomponent of human complement component C1 has been detected in normal plasma samples using the high resolving power of isoelectric focusing in 6 M urea followed by immunoblotting. There are two common alleles at the C1R structural locus that show autosomal codominant inheritance. The C1R*1 and C1R*2 allele frequencies in U.S. white and U.S. black blood donors are: .934, .066, and .899, .101, respectively.
mesh_terms: D000483:Alleles; D044383:Black People; D001798:Blood Proteins / Q000235:genetics*; D003166:Complement Activating Enzymes / Q000235:genetics*; D003172:Complement C1 / Q000235:genetics*; D015923:Complement C1r; D005787:Gene Frequency; D005796:Genes; D006801:Humans; D007525:Isoelectric Focusing; D011110:Polymorphism, Genetic; D044465:White People
chemical_list: D001798:Blood Proteins; D003172:Complement C1; D003166:Complement Activating Enzymes; D015923:Complement C1r