Novobiocin and coumermycin A1 inhibit viral replication and the reactivation of herpes simplex virus type 1 from the trigeminal ganglia of latently infected mice.
Herpes simplex virus type 1 was reactivated from the trigeminal ganglia of latently infected mice in a quantitative and time-dependent manner. Novobiocin and coumermycin A1 reversibly inhibited the reactivation of herpes simplex virus type 1. They did not inhibit viral replication in permissive cells (CV-1) but did inhibit replication in cells of neuronal origin (C1300) and acutely infected trigeminal ganglia.
D049933:Aminocoumarins; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002460:Cell Line; D003374:Coumarins / Q000494:pharmacology; D004195:Disease Models, Animal; D006561:Herpes Simplex / Q000188:drug therapy / Q000382:microbiology; D051379:Mice; D009675:Novobiocin / Q000494:pharmacology*; D012008:Recurrence; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology; D012668:Trigeminal Ganglion / Q000382:microbiology*; D014276:Trigeminal Nerve / Q000382:microbiology*; D014779:Virus Replication / Q000187:drug effects
D049933:Aminocoumarins; D000900:Anti-Bacterial Agents; D003374:Coumarins; D009675:Novobiocin; C004628:coumermycin