env-encoded residues are not required for transformation by p48v-myb.
The v-myb oncogene of avian myeloblastosis virus induces acute myeloblastic leukemia in chickens and transforms avian myeloid cells in vitro. The protein product of this oncogene, p48v-myb, is partially encoded by the retroviral gag and env genes. We demonstrated that the env-encoded carboxyl terminus of p48v-myb is not required for transformation. Our results showed, in addition, that a coding region of c-myb which is not essential for transformation was transduced by avian myeloblastosis virus.
D001354:Avian Leukosis Virus / Q000235:genetics*; D009189:Avian Myeloblastosis Virus / Q000235:genetics* / Q000472:pathogenicity; D002472:Cell Transformation, Viral; D008970:Molecular Weight; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D009857:Oncogenes; D013329:Structure-Activity Relationship; D014759:Viral Envelope Proteins / Q000502:physiology*
D009856:Oncogene Proteins, Viral; D014759:Viral Envelope Proteins