[Effect of beta-endorphin and myelopeptides on the cAMP level and proliferation of lymphocytes in vitro].
Beta-endorphin (10(-11)-10(-9) M) has been shown to induce naloxone-independent depression of the proliferative activity of human peripheral lymphocytes (HL), stimulated by pokeweed mitogen without affecting PHA-stimulated HL proliferation. Beta-endorphin (10(-10)-10(-7) M) also caused changes in HL cAMP level, that were blocked by naloxone. Marked individual sensitivity to beta-endorphin effects has been noted. It has been also shown that a bone marrow preparation, stimulating antibody production (myelopeptides), causes naloxone-independent depression in the proliferative activity of HL, stimulated by PHA and pokeweed mitogen, as well as naloxone-blocked decrease in cAMP HL level. It has been concluded that beta-endorphin interacts with several types of opiate lymphocyte receptors and that opioids, contained in myelopeptides, are involved in the realization of myelopeptide effect on lymphocytes.
D000328:Adult; D001853:Bone Marrow; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009842:Oligopeptides; D010455:Peptides / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects; D001615:beta-Endorphin
D004723:Endorphins; D009842:Oligopeptides; D010455:Peptides; D010835:Phytohemagglutinins; D011957:Receptors, Opioid; C048617:myelopeptides; D001615:beta-Endorphin; D000242:Cyclic AMP
Issledovanie vliianiia beta-éndorfina i mielopeptidov na uroven' tsAMF i proliferatsiiu limfotsitov in vitro.