Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life.
Patients who have received many transfusions become highly sensitized and develop antibodies against almost all HLA alloantigens, so that finding a cross-match negative kidney donor is difficult. A survey of those patients showed that 50 percent did not form antibodies against the noninherited maternal HLA antigens. Apart from the obvious clinical implications, the data indicate that a human equivalent of murine neonatal or actively acquired tolerance has now been identified.
D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D005333:Fetus / Q000276:immunology*; D015234:HLA-A Antigens / Q000276:immunology*; D015235:HLA-B Antigens / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D016030:Kidney Transplantation; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
D015234:HLA-A Antigens; D015235:HLA-B Antigens