Brain Na+,K+-ATPase activity possibly regulated by a specific serotonin receptor.
Na+,K+-ATPase activity in 6 regions of adult brain was measured after incubation with varying concentrations of serotonin. A concentration-dependent increase in enzyme activity was observed in 4 regions, with cerebral cortex and cerebellum showing the largest response. These results together with previous ones suggest that serotonin modulates brain Na+,K+-ATPase activity through a specific receptor located in target neurons or glial cells.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000502:physiology*; D012701:Serotonin / Q000502:physiology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D011985:Receptors, Serotonin; D012701:Serotonin; D000254:Sodium-Potassium-Exchanging ATPase