title: [Inactivation characteristics of polyene macrolide antibiotics].
abstract: Roseofungin, a pentaen was used as an example in investigation of certain characteristics of inactivation of polyenic antibiotics. An inactivation product of the antibiotic having no antiviral or antimycotic activity was isolated by TLC and column chromatography on Sefadex LH-20. UV, IR and EPR spectroscopy showed that this product was cys-tetraen without conjugation of the lactone carbonyl to the polyenic system.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology / Q000627:therapeutic use; D000935:Antifungal Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D001358:Avian Sarcoma Viruses / Q000187:drug effects; D002642:Chick Embryo; D004353:Drug Evaluation, Preclinical; D009980:Influenza A virus / Q000187:drug effects; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy; D011090:Polyenes / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D014616:Vaccinia virus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011090:Polyenes; C009192:roseofungin
vernacular_title: Nekotorye osobennosti inaktivatsii polienovykh makrolidnykh antibiotikov.