Efficacy of vaccination with Skinner vaccine towards the prevention of herpes simplex virus induced cervical carcinoma in an experimental mouse model.
The incidence of cervical carcinoma, which had been induced by vaginal application of inactivated herpes simplex virus type 2 (HSV-2) with 20% croton oil, was significantly reduced in mice prevaccinated with the Skinner herpes vaccine. There was evidence of an immunological response in both vaccinated and unvaccinated mice.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D003436:Croton Oil / Q000633:toxicity; D005260:Female; D006558:Herpes Genitalis / Q000150:complications / Q000517:prevention & control*; D051379:Mice; D018139:Simplexvirus / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D014765:Viral Vaccines / Q000627:therapeutic use*
D000914:Antibodies, Viral; D014765:Viral Vaccines; D003436:Croton Oil