title: Substances affecting the infection and replication of human immunodeficiency virus (HIV).
abstract: The effects of various compounds were studied quantitatively on the growth of human immunodeficiency virus (HIV). For this we used a human T-cell leukemia virus type I carrying cell line, MT-4 which is most permissive for HIV infection. The results are summarized as follows: 1) Prostaglandin E2 and 12-0-tetradecanoylphorbol-13-acetate enhanced the production of HIV significantly in MT-4 cells as well as a continuous HIV producer Molt-4/HTLV-III cells. 2) Interferon gamma, retinoic acid and 3'-azido-3'-deoxythymidine inhibited the replication of HIV at the concentrations which were not cytotoxic. Mechanism of action of these compounds and its clinical implications are discussed.
mesh_terms: D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D017977:Deltaretrovirus / Q000187:drug effects* / Q000502:physiology; D015232:Dinoprostone; D006678:HIV / Q000187:drug effects; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D013936:Thymidine / Q000031:analogs & derivatives / Q000494:pharmacology; D014212:Tretinoin / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine
chemical_list: D011458:Prostaglandins E; D015215:Zidovudine; D014212:Tretinoin; D007371:Interferon-gamma; D015232:Dinoprostone; D013755:Tetradecanoylphorbol Acetate; D013936:Thymidine