Differentiation of poliovirus type I isolates in the 1982 epidemic from Sabin-I strain by antigenic and temperature markers.
Poliovirus type 1 strains recovered from patients with poliomyelitis during the epidemic of 1982, were distinct antigenically from Sabin-1 strain by comparing homologous and heterologous neutralization rate constants of Sabin-1 specific antiserum. With the reproductive capacity at 40 degrees C, these isolates could be easily differentiated from vaccine strain. It was suggested that the epidemic of poliomyelitis in 1982 was not caused by vaccine strain. The 24 isolates reacted with LSc and/or Sabin-1 antisera to the same extent. It was speculated that they might be antigenically similar if not identical. Three isolates which were collected from the later part of epidemic formed small plaques at 40 degrees C. Rabbit antisera against poliovirus strains 3844, Sabin-1, Mahoney and Brunhilde were produced. Antigenic relatedness among the strains was tested by kinetic neutralization. The strain 3844 was distinct from Brunhilde, Mahoney and Sabin-1. Asymmetric cross-reactions between Mahoney and Sabin-1 strains were clearly demonstrated.
D000956:Antigens, Viral / Q000032:analysis*; D004196:Disease Outbreaks; D006801:Humans; D009500:Neutralization Tests; D011051:Poliomyelitis / Q000382:microbiology; D017955:Poliovirus / Q000145:classification* / Q000276:immunology; D011055:Poliovirus Vaccine, Oral / Q000276:immunology*; D013624:Taiwan; D013696:Temperature; D010948:Viral Plaque Assay
D000956:Antigens, Viral; D011055:Poliovirus Vaccine, Oral