Angiotensin-converting enzyme in sarcoid and chalazion granulomas of the conjunctiva.
Angiotensin-converting enzyme (ACE) was studied immunohistochemically in conjunctival biopsies from 6 patients with systemic sarcoidosis, 4 patients with posterior non-sarcoid uveitis and in specimens from 4 patients with chalazion of the eyelid. Specimens with sarcoid granulomas showed intense ACE-positive immunoreactivity in epitheloid cells of the granuloma, whereas chalazion granulomas did not contain ACE-immunoreactivity. There was no difference in staining patterns between specimens without granulomas. Thus immunohistochemical staining for ACE may be of help in differentiating conjunctival granulomatous tissue of a chalazion from sarcoid granuloma.
D003229:Conjunctival Diseases / Q000201:enzymology*; D005141:Eyelid Diseases / Q000201:enzymology*; D006099:Granuloma / Q000201:enzymology* / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D012507:Sarcoidosis / Q000201:enzymology* / Q000276:immunology; D014605:Uveitis / Q000201:enzymology*
D007703:Peptidyl-Dipeptidase A