Dose response relationship of relaxin on the pubic ligament of the mouse.
In the present work, the dose-response relationship of highly purified porcine relaxin has been examined on broadening of the pubic ligament in mice. Using the method of Steinetz et al. with 7 days of oestriol priming, higher sensitivity of the pubic ligament was attained in mice with an original weight of 10 g than in those with a weight of 20 g. S-shaped curves were obtained; by increasing the relaxin doses after maximal effect had been reached a decreased action was observed. With presomen priming, a relaxin effect was established after only 2 days instead of the usual 8 days but the action was markedly less than in the Steinetz test.
D000818:Animals; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology; D005260:Female; D008022:Ligaments / Q000187:drug effects*; D051379:Mice; D011631:Pubic Symphysis / Q000187:drug effects*; D012065:Relaxin / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects
D004966:Estrogens, Conjugated (USP); D004958:Estradiol; D012065:Relaxin