Antimutagenic properties of WR 2721 and of a radioprotective mixture, ATP-AET-serotonin, with regard to X ray induced reciprocal translocations in mouse spermatogonia.
Pretreatment by intraperitoneal administration of WR 2721 at 400 mg/kg body weight in mice receiving 4.0 Gy X rays was found to have an appreciable antimutagenic effect with regard to reciprocal translocation induction in spermatogonia. The effectiveness of the product tested proved superior to that of a radioprotective mixture of ATP-AET-serotonin given at optimal dose ratio--360, 24, and 8 mg/kg body weight, respectively. The RF (Reduction Factor) was 2.4 for WR 2721 and 1.8 for the mixture. The effect observed indicated WR 2721 to have potential capabilities for reducing the genetic risk of radiation in male individuals.
D000255:Adenosine Triphosphate / Q000008:administration & dosage*; D004999:Amifostine / Q000008:administration & dosage*; D000818:Animals; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009946:Organothiophosphorus Compounds / Q000008:administration & dosage*; D012701:Serotonin / Q000008:administration & dosage*; D013093:Spermatogonia / Q000187:drug effects / Q000528:radiation effects*; D013094:Spermatozoa / Q000528:radiation effects*; D014178:Translocation, Genetic / Q000187:drug effects / Q000528:radiation effects*; D000338:beta-Aminoethyl Isothiourea / Q000008:administration & dosage*
D009946:Organothiophosphorus Compounds; D000338:beta-Aminoethyl Isothiourea; D012701:Serotonin; D000255:Adenosine Triphosphate; D004999:Amifostine