title: Fluctuating PEEP (F-PEEP) versus conventional PEEP in dogs with asymmetrical lung injury.
abstract: Fluctuating PEEP (F-PEEP) is a newly developed PEEP in which end-expiratory pressure (EEP) is periodically changed within a certain range. In a dog model with unilateral lung injury induced by the introduction of hydrochloric acid, F-PEEP in which the EEP was periodically changed from 0.5 to 1.5 kPa at periods of 6 min, and conventional PEEP (C-PEEP) with an optimized EEP of 1.0 kPa, were each applied for 30 min. F-PEEP produced a significantly greater improvement of PaO2 and intrapulmonary shunt (QS/QT) than C-PEEP, and at the low EEP phase, the greatest improvement accompanied by an increased dynamic compliance and a large cardiac output was obtained. These results suggest that F-PEEP provides a useful mode of artificial ventilation for the treatment of unilateral lung injury.
mesh_terms: D000818:Animals; D002057:Burns, Chemical / Q000503:physiopathology / Q000628:therapy*; D004285:Dogs; D006439:Hemodynamics; D006851:Hydrochloric Acid; D007384:Intermittent Positive-Pressure Breathing; D008168:Lung / Q000503:physiopathology; D055370:Lung Injury; D011175:Positive-Pressure Respiration / Q000379:methods*; D011659:Pulmonary Gas Exchange
chemical_list: D006851:Hydrochloric Acid