Autoradiographic evidence for beta-adrenergic receptors on capsaicin-sensitive primary afferent terminals in rat spinal cord.
Specific [3H]dihydroalprenolol binding sites are enriched in the dorsal grey matter of rat spinal cord. Neonatal capsaicin treatment, known to cause a permanent loss of a population of primary afferent neurones, caused a significant loss of specific [3H]dihydroalprenolol binding sites from laminae of the dorsal horn. These results suggest that capsaicin-sensitive primary afferent terminals may bear presynaptic beta-adrenergic receptors.
D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D002211:Capsaicin / Q000494:pharmacology; D004082:Dihydroalprenolol / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*
D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D002211:Capsaicin