Collagenase activity in colonic mucosa during inflammatory bowel disease.
A simple test for collagenase activity was performed on colonic mucosa specimens of 35 patients with inflammatory bowel disease, 7 patients with carcinoma of the colon, 3 with benign polyps, and 34 normal subjects. Increased collagenase activity was present in 94.2% of the specimens taken from the inflamed mucosa and 71.4% of those obtained from colonic carcinoma, as compared to 8.8% of the control group.
D004796:Clinical Enzyme Tests; D003092:Colitis / Q000175:diagnosis*; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology*; D003012:Microbial Collagenase / Q000378:metabolism*; D011237:Predictive Value of Tests
D003012:Microbial Collagenase