[DNA repair and its relation to cell division in E. coli].
In E. coli, lesions introduced by agents such as UV radiation, chemical agents, thymine starvation, lead to the induction of a series of bacterial fonctions called the "SOS response" (DNA reparation, mutagenesis, filamentation, prophages induction etc...). Genetics and biochemical study set up the evidences of a regulated mechanism. The central effector of this mechanism is the Rec A protéin. When a cell's DNA is damaged or its DNA replication is inhibited, an inducing signal is generated. The inducing signal reversebly activates a specific protease activity of Rec A which allows it to cleave the Lex A repressor. Thus inducing operons repressed by Lex A. These operons are implicated in DNA reparations and also in cellular division. A coordination between reparation and cellular division is thus established.
D002455:Cell Division; D004249:DNA Damage; D004260:DNA Repair; D004269:DNA, Bacterial / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics*; D009154:Mutation; D009876:Operon
D004269:DNA, Bacterial
La réparation de l'ADN et sa relation avec la division cellulaire chez E. coli.