Suppression of triglyceride secretion by epinephrine in isolated rat hepatocytes.
The effect of epinephrine on triglyceride synthesis and secretion was examined in isolated rat hepatocytes. Epinephrine potently inhibited triglyceride secretion but did not affect cellular triglyceride content or the rate of incorporation of radiolabelled glycerol into cell triglyceride. The inhibitory effect of epinephrine was abolished by inclusion of the alpha-adrenergic antagonist prazosin but not the beta-antagonist propranolol.
D000818:Animals; D002478:Cells, Cultured; D004837:Epinephrine / Q000494:pharmacology*; D005990:Glycerol / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D014280:Triglycerides / Q000378:metabolism*
D011942:Receptors, Adrenergic, alpha; D014280:Triglycerides; D011433:Propranolol; D005990:Glycerol; D011224:Prazosin; D004837:Epinephrine