Fulminant hepatitis due to reactivation of chronic hepatitis B virus infection after allogeneic bone marrow transplantation.
A case of hepatitis B reactivation following bone-marrow transplantation for leukemia in a previously healthy HBsAg carrier is reported. A number of changes in HBV serum markers were contemporary to the acute episode. All of them (increase of HBsAg concentration, conversion from anti-HBe to HBeAg, appearance of anti-HBc IgM and of serum HBV-DNA) were suggestive of a "switching-on" of viral replication. Institution of corticosteroid treatment at the onset of the acute phase did not prevent the fatal outcome.
D000328:Adult; D016026:Bone Marrow Transplantation; D004261:DNA Replication; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000382:microbiology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000502:physiology; D006579:Heterozygote; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007951:Leukemia, Myeloid / Q000628:therapy; D014779:Virus Replication
D006514:Hepatitis B Surface Antigens