Altered vitamin C transport in diabetes mellitus.
Tissues sequester vitamin C in concentrations exceeding that present in plasma. The transmembrane transport mechanisms have been shown to be influenced by the concentration of glucose in vitro. On this basis an impairment of tissue vitamin C status may be present in diabetes mellitus. Recent evidence in support of this hypothesis, first proposed by Mann in 1974, is reviewed.
D001205:Ascorbic Acid / Q000378:metabolism*; D001692:Biological Transport; D003683:Dehydroascorbic Acid / Q000378:metabolism; D003920:Diabetes Mellitus / Q000209:etiology* / Q000378:metabolism; D006801:Humans
D001205:Ascorbic Acid; D003683:Dehydroascorbic Acid