Interleukin-6 enhances growth factor-dependent proliferation of the blast cells of acute myeloblastic leukemia.
The effects of recombinant interleukin-6 (IL-6) on the proliferation of blast precursors present in the peripheral blood of patients with acute myeloblastic leukemia (AML) was investigated. IL-6 had little effect by itself; however, it synergized with granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) in the stimulation of AML blast colony formation. Responsiveness of blast progenitors to IL-6 was heterogeneous. On normal bone marrow cells the same synergy was observed on granulocyte and monocyte precursors (GM-CFC), while there was no significant effect on erythroid and multipotential precursors.
D002455:Cell Division / Q000187:drug effects; D003115:Colony-Stimulating Factors / Q000494:pharmacology; D004357:Drug Synergism; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D007377:Interleukin-3 / Q000494:pharmacology; D015850:Interleukin-6; D007378:Interleukins / Q000494:pharmacology*; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D007377:Interleukin-3; D015850:Interleukin-6; D007378:Interleukins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor