[In vitro movement of human embryonic fibroblasts with normal and anomalous sets of chromosomes].
Migration of diploid postnatal and embryonic diploid and aneuploid cells was studied using a modified method of investigation of leukocyte migration under agarose. The method permits to study migration of fibroblasts and other proliferating cells. Embryonic fibroblasts were shown to move faster, than postnatal fibroblasts. Cells with trisomy 7, 9 and C, and triploid cells were found to move slower than diploid cells. Locomotor disturbances are supposed to be the basis of impairment of morphogenesis in chromosomal anomalies in man.
D000782:Aneuploidy; D002465:Cell Movement; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000503:physiopathology*; D025063:Chromosome Disorders; D002877:Chromosomes, Human / Q000502:physiology*; D003584:Cytological Techniques; D004171:Diploidy; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D011123:Polyploidy
Dvizhenie in vitro émbrional'nykh fibroblastov cheloveka s normal'nymi i anomal'nymi naborami khromosom.