Age-related changes of beta-adrenoceptors in spleen lymphocytes and cerebral cortex of NZB/BIN mice.
The density (Bmax) of beta-adrenoceptors in splenic lymphocytes of NZB/BIN mice decreased up to an age of about 40 weeks and then levelled out. The Bmax in cerebral cortex, on the other hand, increased in the first half of life and then changed relatively little. The dissociation constant of the ligand (Kd) was larger in the cortex than the spleen and showed relatively little age-dependent change.
D000375:Aging / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000648:ultrastructure*; D008214:Lymphocytes / Q000648:ultrastructure*; D051379:Mice; D008814:Mice, Inbred NZB / Q000145:classification; D011943:Receptors, Adrenergic, beta / Q000032:analysis / Q000502:physiology*; D013154:Spleen / Q000166:cytology*
D011943:Receptors, Adrenergic, beta