Granulocyte colony-stimulating factor and differentiation-induction in myeloid leukemic cells.
The granulocyte colony-stimulating factor (G-CSF) belongs to a family of hemopoietic growth factors regulating the production of granulocytes and macrophages. Murine G-CSF stimulates the proliferation and differentiation of precursors of neutrophilic granulocytes and is also able to stimulate the functional activities of mature neutrophils. Among the hemopoietic growth factors, G-CSF has an outstanding capacity to induce terminal differentiation and suppression of self-renewal in myeloid leukemic cells. Murine and human G-CSF's show complete biological cross-reactivity across species and bind equally well to G-CSF receptors of either species. Specific receptors for G-CSF exist on all normal neutrophilic cells and have not been lost in the generation of primary human myeloid leukemias. This data indicates that G-CSF may be a useful reagent in the treatment of myeloid leukemia, in hemopoietic regeneration and in increasing resistance against infections.
D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003115:Colony-Stimulating Factors; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006098:Granulocytes / Q000473:pathology / Q000502:physiology; D006131:Growth Inhibitors; D006133:Growth Substances; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007377:Interleukin-3 / Q000302:isolation & purification / Q000502:physiology* / Q000627:therapeutic use; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D008222:Lymphokines / Q000502:physiology; D051379:Mice; D009363:Neoplasm Proteins / Q000302:isolation & purification / Q000502:physiology* / Q000627:therapeutic use; D011956:Receptors, Cell Surface / Q000502:physiology; D016184:Receptors, Colony-Stimulating Factor; D013045:Species Specificity
D003115:Colony-Stimulating Factors; D006131:Growth Inhibitors; D006133:Growth Substances; D007377:Interleukin-3; D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; C507838:Lif protein, mouse; D008222:Lymphokines; D009363:Neoplasm Proteins; D011956:Receptors, Cell Surface; D016184:Receptors, Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor