Use of 99Tcm radionuclides to show nephrotoxicity of cyclosporin A in transplanted kidneys.
In 60 patients, 99Tcm pertechnetate or 99Tcm methylene diphosphonate was injected through an arm vein within 36 h after renal transplantation and repeated 24 or 48 h later. Thirty-one were treated with azathioprine and prednisone, 27 of the grafts had a well-defined peak on the histograms similar to that from the iliac artery histograms at both examinations. In contrast, of the 29 patients treated with cyclosporin A, only 5 of the grafts had a well-defined peak at both examinations. The difference is highly significant. Treatment with cyclosporin A causes a decrease in renal blood flow in the days immediately after transplantation.
D001379:Azathioprine / Q000009:adverse effects; D003524:Cyclosporins / Q000009:adverse effects*; D005500:Follow-Up Studies; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging*; D016030:Kidney Transplantation; D011241:Prednisone / Q000009:adverse effects; D011877:Radionuclide Imaging; D012039:Regional Blood Flow / Q000187:drug effects; D013670:Sodium Pertechnetate Tc 99m; D013669:Technetium Tc 99m Medronate
D003524:Cyclosporins; D013670:Sodium Pertechnetate Tc 99m; D001379:Azathioprine; D011241:Prednisone; D013669:Technetium Tc 99m Medronate