Peripheral neuropathy associated with experimental plasma cell neoplasm in the mouse.
In order to investigate the role of paraproteins in the production of neuropathy we experimentally induced monoclonal immunoglobulin-producing tumours into 32 BALB/c mice by injecting mineral oil or pristane intraperitoneally. In 11 mice morphologic and histometric studies of the sciatic nerve revealed the presence of neuropathy. Immunohistochemical studies did not demonstrate a significant amount of immunoglobulins and light chains in the endoneurium. The advantages and limits of this experimental model are discussed.
D000818:Animals; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010265:Paraproteinemias / Q000150:complications* / Q000276:immunology; D010525:Peripheral Nerves / Q000276:immunology* / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D010954:Plasmacytoma / Q000150:complications* / Q000473:pathology