title: Dose-response relationships for adrenocorticotrophin-induced hypertension in man.
abstract: Adrenocorticotrophin (ACTH), given as long-acting Synacthen depot (Ciba-Geigy), at 1000 micrograms/day, in divided doses 12 hourly, is known to increase blood pressure in man. Fifty micrograms/day of short-acting Synacthen given intravenously produced a rise in blood pressure and may be a threshold dose. Twelve hourly intramuscular injections of short-acting Synacthen over the dose range 100-400 micrograms/day was not sufficient to raise blood pressure.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged
chemical_list: D000324:Adrenocorticotropic Hormone