Expression of growth regulatory genes in primary human testicular neoplasms.
Seven testicular tumours of different histological type--two seminomas, two teratomas/teratocarcinomas/embryonal carcinomas, one mixed seminoma/teratoma, one Leydig cell tumour and one testicular lymphoma--were examined for the expression of four potentially growth regulatory genes by Northern blotting. Seven out of seven testicular tumours contained transcripts that hybridized with a human insulin cDNA-probe whereas only four out of seven tumours contained IGF II transcripts. One tumour contained high levels of LDL-receptor transcript whereas all seven tumours contained significant quantities of HMG-CoA-reductase mRNA.
D004247:DNA / Q000378:metabolism; D004407:Dysgerminoma / Q000235:genetics / Q000378:metabolism; D005796:Genes; D005809:Genes, Regulator; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics; D007328:Insulin / Q000235:genetics; D007335:Insulin-Like Growth Factor II / Q000235:genetics; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics* / Q000378:metabolism; D012334:RNA, Neoplasm / Q000302:isolation & purification; D011973:Receptors, LDL / Q000235:genetics; D013724:Teratoma / Q000235:genetics / Q000378:metabolism; D013736:Testicular Neoplasms / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
D007328:Insulin; D012334:RNA, Neoplasm; D011973:Receptors, LDL; D007335:Insulin-Like Growth Factor II; D004247:DNA; D006903:Hydroxymethylglutaryl CoA Reductases