title: ACTH-producing microadenoma of the pituitary in a young female infant with Cushing's disease: report of a case including immunocytologic and ultrastructural studies.
abstract: A female infant, younger than any other case in the literature, with ACTH-producing microadenoma of the pituitary is reported. She had full-blown symptoms and signs as well as laboratory evidence of Cushing's disease. The tumor was investigated by histology, immunocytology (avidin-biotin-peroxidase complex technique), and electron microscopy. The possibility that the tumor was derived from the fetal intermediate lobe is discussed.
mesh_terms: D000236:Adenoma / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis*; D003480:Cushing Syndrome / Q000209:etiology*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008854:Microscopy, Electron; D010902:Pituitary Gland / Q000473:pathology; D010911:Pituitary Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology
chemical_list: D000324:Adrenocorticotropic Hormone