Platelet binding studies in panic disorder.
Binding parameters of the alpha 2-adrenoceptor (using [3H]yohimbine) and the 5-HT uptake site (using [3H]imipramine) were measured in intact platelets in a group of 15 patients with a DSM-III diagnosis of panic disorder. When compared with an age- and sex-matched control population no differences in either Bmax or Kd were found. This result is discussed in light of the reports of platelet binding abnormalities in depression.
D000328:Adult; D001008:Anxiety Disorders / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D005239:Fear / Q000502:physiology*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*; D015016:Yohimbine / Q000097:blood
D011942:Receptors, Adrenergic, alpha; D011985:Receptors, Serotonin; D015016:Yohimbine; D007099:Imipramine