[Effect of ACTH fragments on the aggressive-defensive behavior of the rat].
ACTH4-10 and ACTH5-10 enhanced the fear response and footshock-induced aggression in male rats (50 and 150 mcg/kg, i.p.). ACTH4-10 seemed to produce the corticotropin (ACTH1-39) neuromodulatory behavioral effect which involved the facilitation of the brain muscarinic receptor activation.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000187:drug effects; D003900:Desoxycorticosterone / Q000494:pharmacology; D005239:Fear / Q000187:drug effects; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000187:drug effects
D010446:Peptide Fragments; D011976:Receptors, Muscarinic; C035065:ACTH (5-10); D003900:Desoxycorticosterone; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10); D006854:Hydrocortisone
Vliianie fragmentov AKTG na agressivno-oboronitel'noe povedenie krys.