title: Anti-herpes virus combinations in relation to drug resistance.
abstract: Two broad categories of combinations have been subject to experimental investigation against HSV-1 and HSV-2; those consisting of an active antiviral drug and an inhibitor of its catabolism and those which contain two active antiviral agents. The latter seek to exploit biochemical mechanisms likely to lead to a synergistic or complementary interaction. Examples of both types of combination for the suppression of resistance development and for the treatment of infection caused by resistant strains are discussed. Their possible relevance to the latent state is considered.
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage; D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage*; D011756:Diphosphates / Q000008:administration & dosage; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D017245:Foscarnet; D006561:Herpes Simplex / Q000188:drug therapy*; D066298:In Vitro Techniques; D019384:Nucleic Acid Synthesis Inhibitors; D010746:Phosphonoacetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives; D018139:Simplexvirus / Q000187:drug effects*; D013937:Thymidine Kinase / Q000037:antagonists & inhibitors; D014543:Uridine Phosphorylase / Q000037:antagonists & inhibitors; D014740:Vidarabine / Q000008:administration & dosage
chemical_list: D058892:Adenosine Deaminase Inhibitors; D000998:Antiviral Agents; D011756:Diphosphates; D019384:Nucleic Acid Synthesis Inhibitors; D017245:Foscarnet; D014543:Uridine Phosphorylase; D013937:Thymidine Kinase; D014740:Vidarabine; D010746:Phosphonoacetic Acid; D000212:Acyclovir