Transient engraftment of T cell-depleted allogeneic bone marrow in mice improves survival rate following lethal irradiation.
C3H/HeJ mice were exposed to 8 or 9 Gy total body irradiation prior to transplantation of 1-15 x 10(6) H-2 incompatible T cell-depleted bone marrow cells from C57BL/6 donors. Survival was greatly enhanced compared to irradiated controls, even at the lowest cell doses. Analysis of spleen cells 1-7 weeks post-transplant revealed that recipients of the lowest doses of T cell-depleted bone marrow had only transient engraftment of donor type cells, and that long-term recovery was autologous. This transient engraftment had a marked beneficial effect both on reconstitution of hematopoiesis and on survival.
D000818:Animals; D001853:Bone Marrow / Q000502:physiology / Q000528:radiation effects; D016026:Bone Marrow Transplantation; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006085:Graft Survival / Q000528:radiation effects*; D006410:Hematopoiesis; D008136:Longevity; D008212:Lymphocyte Depletion; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D011828:Radiation Chimera; D013601:T-Lymphocytes