Facilitation of premotor cortical seizure development by intranigral muscimol.
The role of the substantia nigra in seizure development was investigated using a chronic model of partial onset generalized seizure induced by low frequency cortical stimulation. Unilateral intranigral micro-injection of muscimol, a GABA receptor agonist, was found to facilitate partial onset seizure development, but did not affect developed seizures. This finding suggested that a non-dopaminergic, presumably GABAergic, mechanism was involved since the facilitatory effect of intranigral muscimol was not modified by haloperidol pretreatment.
D000818:Animals; D004298:Dopamine / Q000502:physiology; D004828:Epilepsies, Partial / Q000503:physiopathology*; D008297:Male; D008845:Microinjections; D009044:Motor Cortex / Q000503:physiopathology*; D009118:Muscimol; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000503:physiopathology*; D009435:Synaptic Transmission; D013787:Thalamic Nuclei / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D004298:Dopamine