[A case report of patient with advanced stomach carcinoma of linitis plastica type responding to multi-immunotherapy and chemotherapy].
Multiple-drug (OK-432, PSK and SPG) immunotherapy and chemotherapy provided remission of symptoms for 36 months in a patient aged 21 years suffering scirrhous gastric carcinoma associated with carcinomatous peritonitis in which direct infiltration to the pancreas, retroperitoneum and the left colon was observed. A remarkable improvement with time was observed by endoscopic and roentgenographic observation, and a substantial improvement was also observed in the NK-cell ratios of lymphocyte subsets of the OKT series in relation to immunologic parameters. A tumor necrosis factor [TNF]-like substance was thought to have been induced by multiimmunotherapy in this case.
D002293:Adenocarcinoma, Scirrhous / Q000188:drug therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001688:Biological Products / Q000008:administration & dosage*; D002225:Carbazilquinone / Q000008:administration & dosage; D006025:Glycosaminoglycans / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D010844:Picibanil / Q000008:administration & dosage*; D011509:Proteoglycans / Q000008:administration & dosage*; D012566:Sizofiran / Q000008:administration & dosage*; D013274:Stomach Neoplasms / Q000188:drug therapy*
D001688:Biological Products; D006025:Glycosaminoglycans; D008937:Mitomycins; D011509:Proteoglycans; D002225:Carbazilquinone; D010844:Picibanil; C010770:polysaccharide-K; D016685:Mitomycin; D012566:Sizofiran