title: Recovery of tactile placing after visual cortex ablation in cat: a behavioral and metabolic study of diaschisis.
abstract: After bilateral visual cortex ablation, cats show a transient deficit in tactile placing and a permanent deficit in visual placing of both forelimbs. Amphetamine administration (four doses, 5 mg/kg, i.p., spaced at 4-day intervals beginning 10 days after surgery) accelerated the rate of recovery of tactile placing compared with saline controls whereas visual placing was not affected. The catecholamine antagonist, haloperidol (0.4 mg/kg, i.p.), blocked the amphetamine-enhanced recovery of tactile placing. Additionally, the visual cortex lesions produced a depression of oxidative metabolism, measured by cytochrome oxidase histochemistry, in subcortical regions remote from the injury. Animals treated with amphetamine exhibited an alleviation of this metabolic depression in the superior colliculus but not in other regions.
mesh_terms: D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D002415:Cats; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D006651:Histocytochemistry; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology*; D014110:Touch / Q000502:physiology; D014793:Visual Cortex / Q000201:enzymology / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology
chemical_list: D000661:Amphetamine; D003576:Electron Transport Complex IV