Kininase I, kininase II and aminopeptidase levels in patients with gastrointestinal tumors.
Some indices of the kallikrein kinin system, namely kininase I (KI), kininase II or angiotensin converting enzyme (KII-ACE) and phenylalanine-arginine aminopeptidase (AP) were analyzed, to detect their levels in ten selected normal subjects and in 20 selected patients with colonic (n = 8) and gastric adenocarcinoma (n = 12). While AP and KI levels did not show differences in the groups under analysis, KII values showed a significant difference (P +/- 0.01), present since the early stages of the diseases and unrelated to the normal laboratory indices.
D000230:Adenocarcinoma / Q000201:enzymology*; D000328:Adult; D000368:Aged; D000626:Aminopeptidases / Q000097:blood*; D002268:Carboxypeptidases / Q000097:blood*; D003110:Colonic Neoplasms / Q000201:enzymology*; D005260:Female; D006801:Humans; D001121:Lysine Carboxypeptidase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D013274:Stomach Neoplasms / Q000201:enzymology*
D002268:Carboxypeptidases; D000626:Aminopeptidases; C049035:phenylalanine aminopeptidase; C019721:aminopeptidase B; D007703:Peptidyl-Dipeptidase A; D001121:Lysine Carboxypeptidase