Free radical modification of low-density lipoprotein: mechanisms and biological consequences.
Low-density lipoprotein readily undergoes lipid peroxidation that is accompanied by apoprotein fragmentation. Oxidized forms of low-density lipoprotein show altered biological behavior, including changes in receptor recognition and cytotoxicity to cells in culture. In this review, free radical mechanisms and the biological consequences of low-density lipoprotein modification are discussed.
D000818:Animals; D001055:Apolipoproteins B / Q000378:metabolism; D001161:Arteriosclerosis / Q000209:etiology; D002470:Cell Survival / Q000187:drug effects; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism* / Q000494:pharmacology; D008670:Metals / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D011973:Receptors, LDL / Q000187:drug effects; D013481:Superoxides / Q000378:metabolism
D001055:Apolipoproteins B; D005609:Free Radicals; D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; D008670:Metals; D011973:Receptors, LDL; D013481:Superoxides; D006861:Hydrogen Peroxide; D010741:Phospholipases A