[Participation of metabolic systems of carotid chemoreceptors in their effector regulation].
Electrical stimulation of the rat sinus nerve altered fluorescence of restored pyridin nucleotides and oxidative flavoproteids in the carotid body cells due to enhancement of cellular respiration. This was followed by an increase of cGMP content in the carotid body. The greatest shifts of these parameters occurred in square-wave stimulation with 20/sec frequency. The effector influences on the carotid body metabolism are most effectively blocked with pentamine and seem to be of cholinergic nature, the transmitter effect of acetylcholine being modulated with enkephalins. The cGMP system may serve as an intermediary of the effector influences.
D000818:Animals; D001339:Autonomic Fibers, Preganglionic / Q000502:physiology; D002344:Carotid Body / Q000378:metabolism*; D002799:Cholinergic Fibers / Q000502:physiology; D006152:Cyclic GMP / Q000032:analysis; D005420:Flavoproteins / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009451:Neuroeffector Junction / Q000502:physiology; D010084:Oxidation-Reduction; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology
D005420:Flavoproteins; D000644:Quaternary Ammonium Compounds; D009243:NAD; C040648:pentamine; D006152:Cyclic GMP
Ob uchastii metabolicheskikh sistem karotidnykh khimioretseptorov v ikh éffektornoĭ reguliatsii.