Cultivation and characterization of human rotaviruses with "super short" RNA patterns.
Two group A, subgroup I, rotavirus strains possessing "super short" RNA patterns were adapted to growth in MA-104 cells. Both produced marked cytopathic effect in primary culture. Reciprocal cross-neutralization titers, polypeptide analysis, and the serum neutralizing antibody response of an infected child suggested that super short viruses are serotypically distinct from the four recognized human serotypes.
D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007223:Infant; D008970:Molecular Weight; D009500:Neutralization Tests; D010455:Peptides / Q000032:analysis; D012367:RNA, Viral / Q000032:analysis*; D012401:Rotavirus / Q000145:classification / Q000235:genetics* / Q000502:physiology; D012703:Serotyping
D000914:Antibodies, Viral; D000956:Antigens, Viral; D010455:Peptides; D012367:RNA, Viral