[Effect of ACTH injection and graft of bursa of Fabricius on the adrenocortical activity of bursectomized chicks at 80 hours of incubation].
Early embryonic bursectomy (BFX) disturbed the adrenocortical functioning. The stress-unresponsive period that occurred in controls, and lasted for 2-3 weeks after hatching, no longer appeared in BFX chicks. In contrast, the magnitude of the stress-induced hypercorticosteronemia was much lower in BFX than in sham-operated 5 week-old chicken. It was assumed that such adrenocortical dysfunction was due to bursal deprivation, since grafting bursal buds onto the chorio-allantoic membrane of BFX embryos restored all the parameters under study, i.e., the post-hatching stress unresponsive period and the high magnitude of stress-induced responses in adults. Factor(s) involved in such interregulation are not known but do not seem to affect directly adrenocortical cells because intramuscular injection of a moderate dose of ACTH resulted in the same hypercorticosteronemia whether 3 day-old and 5 week-old chicks had been bursectomized or sham-operated.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002060:Bursa of Fabricius / Q000601:surgery / Q000637:transplantation*; D002642:Chick Embryo; D002645:Chickens / Q000097:blood; D003345:Corticosterone / Q000097:blood*; D004986:Ether / Q000494:pharmacology; D013997:Time Factors
D004986:Ether; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone
Effets de l'injection d'ACTH et de la greffe de bourse de Fabricius sur l'activité corticosurrénalienne des poussins et poulets bursectomisés à 80 heures d'incubation.