[Role of cyclic 3',5'-adenosine monophosphate in the development of Salmonella infection in an experiment].
The changes in cAMP levels in spleen macrophages of mice infected with low-virulent and virulent Salmonella strains and the effect of propranolol on Salmonella reproduction in the spleen, and the outcome of Salmonella-induced infection have been studied. A persistent increase in cAMP levels in spleen macrophages during Salmonella infection caused by virulent Salmonella strains has been demonstrated. Low-virulent Salmonella strains failed to cause the elevation of cAMP levels in spleen macrophages. Propranolol injection to mice prevented intensive Salmonella reproduction in the spleen and diminished the animal mortality rate.
D000818:Animals; D000242:Cyclic AMP / Q000032:analysis / Q000502:physiology*; D004353:Drug Evaluation, Preclinical; D008264:Macrophages / Q000032:analysis; D051379:Mice; D008808:Mice, Inbred CBA; D011433:Propranolol / Q000627:therapeutic use; D012475:Salmonella / Q000472:pathogenicity; D012481:Salmonella Infections, Animal / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D013154:Spleen / Q000032:analysis / Q000382:microbiology; D014774:Virulence
D011433:Propranolol; D000242:Cyclic AMP
Issledovanie roli tsiklicheskogo 3',5'-adenozinmonofosfata v razvitii sal'monelleznoĭ infektsii v éksperimente.