Experimental studies on Marek's disease in Japanese quail (Coturnix coturnix japonica).
Day-old quails experimentally infected with Marek's disease (MD) virus of quail origin developed lymphoid tumors. The severity of the disease increased considerably with serial passage. Tumor transplants could be made with cells derived from gross tumors in skeletal muscles, spleen cells, and blood from MD-affected quails. After five to six serial transplants, the tumor could not be transplanted further. Marek's disease tumor-associated surface antigen (MATSA) was demonstrated in lymphoid cells of spleen and peripheral blood lymphocytes of MD-affected quails. The MATSA of quail differed from the MATSA of chicken. Chickens were susceptible to MD virus isolated and propagated in quails.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D000957:Antigens, Viral, Tumor / Q000032:analysis; D002478:Cells, Cultured; D002645:Chickens; D003370:Coturnix; D003588:Cytopathogenic Effect, Viral; D005347:Fibroblasts; D005455:Fluorescent Antibody Technique; D008381:Herpesvirus 2, Gallid / Q000276:immunology / Q000472:pathogenicity*; D008380:Marek Disease / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D009368:Neoplasm Transplantation; D011784:Quail; D014774:Virulence
D000954:Antigens, Surface; D000956:Antigens, Viral; D000957:Antigens, Viral, Tumor