Overproduction of protein p53 contributes to simian virus 40-mediated transformation.
The possible involvement of p53 overproduction in simian virus 40 (SV40)mediated transformation was studied by using the rat embryo fibroblast focus formation assay. Transformation by wild-type SV40 was enhanced two- to threefold by cotransfection of a plasmid overexpressing mouse p53. More significantly, such a plasmid could partially complement a transformation-defective deletion mutant of SV40. Hence, the ability of SV40 T antigen to induce high p53 levels may indeed be directly relevant to the viral transforming potential.
D000818:Animals; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D005796:Genes; D005814:Genes, Viral; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics*; D010750:Phosphoproteins / Q000235:genetics*; D013539:Simian virus 40 / Q000235:genetics*; D014162:Transfection; D016159:Tumor Suppressor Protein p53
D009363:Neoplasm Proteins; D010750:Phosphoproteins; D016159:Tumor Suppressor Protein p53