Inhibition of metabolic response of polymorphonuclear leukocyte by biscoclaurine alkaloids.
Effects of biscoclaurine alkaloids on the various stimulus-responses of PMN, especially on the O2-. generation of PMN, were investigated. Results obtained were: cepharanthine inhibited various metabolic responses of PMN, its biological action probably being due to its membrane modifying action. Inhibition of O2-. generation by cepharanthine was stronger than any other inhibition of metabolic responses of PMN. The inhibitory effect of various biscoclaurine alkaloids on the O2-. generation of PMN was the descending order of tri-, di- and mono-ether type; the coclaurine type showed only a weak effect.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D044182:Benzylisoquinolines; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D006168:Guinea Pigs; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D052117:Benzodioxoles
D000470:Alkaloids; D044182:Benzylisoquinolines; D002118:Calcium; D009240:N-Formylmethionine Leucyl-Phenylalanine; D011188:Potassium; D013481:Superoxides; C006947:cepharanthine; D052117:Benzodioxoles