Myc family of cellular oncogenes.
The myc family of cellular oncogenes contains three well-defined members: c-myc, N-myc and L-myc. Additional structural and functional evidence now suggests that other myc-family oncogenes exist. The overall structure and organization of the c-, N-, and L-myc genes and transcripts are very similar. Each gene contains three exons: encoding a long 5' untranslated leader and a long 3' untranslated region. The proteins encoded by these myc genes share several stretches of significant homology. The conservation of sequences at the carboxyterminus of the L-myc protein suggests that it is also a DNA-binding, nuclear-associated protein. Each myc gene will cooperate with an activated Ha-ras oncogene to cause transformation of primary rat embryo fibroblasts. Characteristics of several new myc-family members are described.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D005810:Multigene Family; D009856:Oncogene Proteins, Viral / Q000502:physiology; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000502:physiology; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic; D009396:Wilms Tumor / Q000235:genetics
D009856:Oncogene Proteins, Viral; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger