Parapharyngeal malignant ectomesenchymoma: combined malignant fibrous histiocytoma and primitive neuroectodermal tumour with neuroglial differentiation.
A parapharyngeal ectomesenchymoma consisting of mixed malignant fibrous histiocytoma and primitive neuroectodermal tumour with neuroglial differentiation occurred in a 36-year-old woman. Immunohistochemical and electron microscopic studies verified the combined mesenchymal and neuroectodermal components within the tumour. Only 9 similar cases, including the present one, are on record. The patients ranged in age from 6 months to 49 years, with an average age of 18 years. The male:female ratio was 4:5. The tumour location was widespread. All reported ectomesenchymomas were histopathologically malignant. Recurrence and/or metastasis was/were common. The neural crest has been suggested as the origin of the ectomesenchymomas.
D000328:Adult; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology*; D006801:Humans; D008854:Microscopy, Electron; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology*; D010610:Pharyngeal Neoplasms / Q000473:pathology* / Q000648:ultrastructure