title: Dexfenfluramine: effects on food intake in various animal models.
abstract: The effects of dexfenfluramine on food intake of rats are compared and contrasted among several paradigms. Paradigms that involve overfeeding rather than deprivation, show a greater effect of the agent. Furthermore, both stress-induced eating as well as a food-motivated response (running) are particularly sensitive to inhibition by dexfenfluramine. The results of chronic administration of dexfenfluramine on both behavior and neurochemistry are reviewed, with particular reference to brain 5-HT. The effects of dexfenfluramine on diet selection and conditioned preferences are discussed. Finally, we suggest that species differences may exist in either the neurochemical and/or behavioral responses to dexfenfluramine.
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004435:Eating / Q000187:drug effects*; D005277:Fenfluramine / Q000494:pharmacology*
chemical_list: D005277:Fenfluramine