Repeated treatment with antidepressant drugs does not affect the benzodiazepine receptors in preincubated membrane preparations from mouse and rat brain.
Repeated injections or oral administration of antidepressants: imipramine, amitriptyline and desmethylimipramine (10 mg/kg twice daily for 21 days) did not alter significantly [3H]flunitrazepam binding to frozen-thawed preincubated membranes from the brains of mice or rats.
D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003891:Desipramine / Q000494:pharmacology; D005445:Flunitrazepam / Q000378:metabolism; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism
D000928:Antidepressive Agents; D011963:Receptors, GABA-A; D000639:Amitriptyline; D005445:Flunitrazepam; D007099:Imipramine; D003891:Desipramine