title: Genome segment reassortment between two serotypes of bluetongue virus in a natural host.
abstract: The occurrence of genome segment reassortment between two antigenically related orbiviruses was demonstrated in cattle. Individual virus clones were isolated by cell culture plaque assays directly from the blood of a calf infected with two serotypes of bluetongue virus. The majority (89%) of progeny viruses isolated from the calf represented reassortant viruses. A minimum of six genome segments participated in reassortment, with 16 unique reassortant constellations being identified. Such genome segment reassortment between unique, though antigenically related, orbiviruses has undoubtedly played a major role in generating the extensive phenotypic and genotypic diversity that is characteristic of this serogroup.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001820:Bluetongue virus / Q000235:genetics* / Q000276:immunology; D002417:Cattle; D005814:Genes, Viral; D005838:Genotype; D008297:Male; D012367:RNA, Viral / Q000032:analysis; D012087:Reoviridae / Q000235:genetics*; D012703:Serotyping
chemical_list: D000914:Antibodies, Viral; D012367:RNA, Viral