Inhibition of BK virus haemagglutination by gangliosides.
The effect of gangliosides extracted from human group O Rh+ erythrocytes on haemagglutination by BK virus was investigated. Experiments were performed on both ganglioside mixtures and isolated fractions separated by column chromatography and characterized by thin-layer chromatography. These results were compared with those obtained with standard preparations of gangliosides, and the inhibiting activity was shown to be confined mainly to gangliosides with a RF lower than GM1. It was also observed that the insertion of gangliosides in liposomes increased the haemagglutination-inhibiting activity and that ganglioside coating restored the ability of glycosidase-treated human red blood cells to agglutinate.
D001739:BK Virus / Q000187:drug effects / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D005732:Gangliosides / Q000097:blood / Q000494:pharmacology*; D006387:Hemagglutination, Viral / Q000187:drug effects*; D006801:Humans; D011120:Polyomavirus / Q000276:immunology*
D005732:Gangliosides