title: [Synthesis of lipid A analogs: achievements and perspective].
abstract: Data on the synthesis of analogues of lipid A, a biologically active fragment of gram-negative bacteria's lipopolysaccharides, are summarized. Main types of the compounds obtained are systematized, and problems of the synthesis of various parts of the molecule considered. The results of studying biological activity of lipid A analogues are discussed, which led to some conclusions on the structure-function relation. Perspectives of further studies are briefly outlived.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D008050:Lipid A / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D008050:Lipid A
vernacular_title: Sintez analogov lipida A: dostizheniia i perspektivy.