Autosomal dominant carpal tunnel syndrome in a Karaite family.
A clinical examination and a history of 64 members belonging to four generations of a Karaite kindred revealed 11 patients with carpal tunnel syndrome (CTS). Bilateral involvement and early age of onset are salient features. The mutation may be traced in four generations. Hereditary primary CTS may be more prevalent than hitherto suspected.
D000328:Adult; D002349:Carpal Tunnel Syndrome / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D002675:Child, Preschool; D004534:Egypt / Q000208:ethnology; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D007557:Israel; D007585:Jews; D008297:Male; D010375:Pedigree