[Pregnancy protein-1 in the serum of patients with diseases of the breast].
Pregnancy-specific beta 1-glycoprotein (SP1) was assayed by enzyme immunoassay in serum from 32 patients with breast diseases (11 mastopathies, 6 benign tumors and 15 breast cancers). Healthy blood donors were used as control group. There were significant differences between the SP1-serum concentrations of patient group (mastopathies, benign tumors, breast cancer) and the control group (p less than 0.001). The SP1-values of the groups with mastopathies, benign tumors and breast cancer did not differ significantly. Elevated SP1-concentrations were found in 4 of 11 patients with mastopathy, in 3 of 6 patients with benign tumor and in 10 of 15 patients with breast cancer versus 1 of 24 blood donors. With the help of SP1 determination in serum of 5 breast cancer patients before operation and 6 months post operation we did not found a correlation with further clinical course.
D002293:Adenocarcinoma, Scirrhous / Q000175:diagnosis; D000293:Adolescent; D000328:Adult; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis*; D002277:Carcinoma / Q000175:diagnosis; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D005348:Fibrocystic Breast Disease / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011257:Pregnancy Proteins / Q000032:analysis*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis*
D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins
Das Schwangerschaftsprotein-1 (SP1) im Serum von Patientinnen mit Erkrankungen der Brustdrüse.