title: Transcription of a human transposon-like sequence is usually directed by other promoters.
abstract: The transcriptional activity of a human transposon-like family of repeats, called the THE-1 family, has been studied in cell culture and in human tissue. Both strands of THE-1 are present in several discrete length poly A plus RNAs. Primer extension studies and the structures of cDNA clones show that these THE-1 transcripts are usually the product of other transcription units. The THE-1 LTR provides the polyadenylation processing site for two transcripts, which result from upstream non THE-1 promoters. Yet another transcript, containing an internal THE-1 element in the probable sense orientation, is greatly enriched in a polysomal size fraction.
mesh_terms: D001483:Base Sequence; D002467:Cell Nucleus / Q000032:analysis; D003600:Cytosol / Q000032:analysis; D004251:DNA Transposable Elements; D006367:HeLa Cells / Q000032:analysis; D006801:Humans; D011132:Polyribosomes / Q000032:analysis; D011401:Promoter Regions, Genetic; D012334:RNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D012335:RNA, Ribosomal / Q000235:genetics / Q000302:isolation & purification; D012091:Repetitive Sequences, Nucleic Acid; D014158:Transcription, Genetic
chemical_list: D004251:DNA Transposable Elements; D012334:RNA, Neoplasm; D012335:RNA, Ribosomal