[Experimental Enterobacter cloacae endocarditis treated with gentamicin. Predictive value of the in vitro bactericidal rate].
The predictive value of in vitro time-kill curve was tested on an Enterobacter cloacae endocarditis experimental model. The antibiotic studied was gentamicin. Despite a similar MIC, 2 Enterobacter cloacae strains exhibited very different time-kill curves in vitro. This difference was found being predictive of efficacy on the in vivo model, 24 hours after a single injection of gentamicin.
D000818:Animals; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D004754:Enterobacter / Q000187:drug effects*; D004755:Enterobacteriaceae / Q000187:drug effects*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy*; D005260:Female; D005839:Gentamicins / Q000494:pharmacology / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D011817:Rabbits
D005839:Gentamicins
Endocardite expérimentale à Enterobacter cloacae traitée par la gentamicine. Valeur prédictive de la vitesse de bactéricidie in vitro.