Dopaminergic and benzodiazepine receptors studied in vivo by PET.
Using Positron Emission Tomography (PET) and specific radioligands, dopaminergic D2 (DA-D2 receptors) and benzodiazepine receptors (BZ-receptors) were studied in living animals during normal and pathological conditions. In vivo characterization of both receptors was performed using two highly specific antagonists namely: 11C-Ro 15 1788 for BZ-receptors and 76 Br-Bromospiperone for DA-D2 receptors. Changes in 11c-Ro 15 1788 specific binding to BZ-receptors were observed during convulsive seizures. After MPTP treatment, a decrease in the 76 Br-Bromospiperone striatal specific binding was observed, correlated with the establishment of a Parkinson-like syndrome.
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D001966:Bromine; D002250:Carbon Radioisotopes; D005442:Flumazenil / Q000378:metabolism; D007700:Kinetics; D008297:Male; D010215:Papio; D011868:Radioisotopes; D011869:Radioligand Assay; D011954:Receptors, Dopamine / Q000378:metabolism*; D011963:Receptors, GABA-A / Q000378:metabolism*; D013134:Spiperone / Q000031:analogs & derivatives / Q000378:metabolism; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D011868:Radioisotopes; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D005442:Flumazenil; D013134:Spiperone; C026326:4-bromospiperone; D001966:Bromine