title: [Low levels of chloroquine resistance of Plasmodium falciparum in the province of Zou in Benin].
abstract: An in vivo test using the WHO protocol (chloroquine 25 mg/kg within 3 days, trial over 7 days) was performed in 72 children in the province of Zou, Benin, in July-August 1987. The blood concentration of chloroquine was dosed before, during and after treatment by a sensitive method. This study showed a low rate of drug resistance (4.2%), even though surveys in Cotonou exhibited a high level of chloroquine resistance.
mesh_terms: D000818:Animals; D001541:Benin; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D004351:Drug Resistance; D006801:Humans; D007223:Infant; D008288:Malaria / Q000517:prevention & control; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D002738:Chloroquine
vernacular_title: Faible niveau de chloroquinorésistance de Plasmodium falciparum dans la province du Zou au Bénin.