Formation of sulphidopeptide-leukotrienes in brain tissue of spontaneously convulsing gerbils.
Five minutes after the onset of seizures high amounts of immunoreactive prostaglandin (PG) F2 alpha and smaller amounts of sulphidopeptide (SP)-leukotriene (LT)-like immunoreactivity could be detected in gerbil brain tissue. Bilateral carotid artery ligation followed by 15 min of reperfusion even more enhanced brain tissue contents of PGF2 alpha and SP-LT-like material. Analysis of the immunoreactive SP-LT-like material by reversed phase high pressure liquid chromatography (h.p.l.c.) revealed immunoreactivity co-eluting with authentic LTC4 and LTD4.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005849:Gerbillinae; D002546:Ischemic Attack, Transient / Q000503:physiopathology; D017999:Leukotriene E4; D013189:SRS-A / Q000031:analogs & derivatives* / Q000378:metabolism*; D012640:Seizures / Q000503:physiopathology*
D013189:SRS-A; D017999:Leukotriene E4