Assessment of a general therapeutic protocol for the treatment of acute T-2 toxicosis in swine.
T-2 toxin, a trichothecene mycotoxin suspected of being used as a chemical warfare agent, was administered iv to swine at a dose of 3.6 mg/kg body weight (iv LD50 approximately 1.2 mg/kg). Four different therapeutic protocols were assessed for their efficacy in the treatment of the resultant acute T-2 toxicosis syndrome. One therapeutic protocol included the combined use of metoclopramide, activated charcoal, magnesium sulfate, dexamethasone sodium phosphate, sodium bicarbonate and normal saline. The other 3 protocols utilized the same agents less 1 of the following: the combination of activated charcoal and magnesium sulfate, sodium bicarbonate, or normal saline. All 4 treatment groups showed improved survival times compared to a positive T-2 control group. Within the limits of the study, it would appear that the removal of activated charcoal and magnesium sulfate was most detrimental to the T-2 toxin-dosed swine.
D000818:Animals; D001639:Bicarbonates / Q000627:therapeutic use; D002606:Charcoal / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D007928:Lethal Dose 50; D008278:Magnesium Sulfate / Q000627:therapeutic use; D008787:Metoclopramide / Q000627:therapeutic use; D009145:Mushroom Poisoning / Q000188:drug therapy / Q000628:therapy / Q000662:veterinary*; D012717:Sesquiterpenes / Q000506:poisoning*; D012964:Sodium / Q000627:therapeutic use; D017693:Sodium Bicarbonate; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000628:therapy*; D013605:T-2 Toxin / Q000506:poisoning*; D013997:Time Factors
D001639:Bicarbonates; D012717:Sesquiterpenes; D002606:Charcoal; D008278:Magnesium Sulfate; D003907:Dexamethasone; D017693:Sodium Bicarbonate; D012964:Sodium; D013605:T-2 Toxin; D008787:Metoclopramide