title: [3H] imipramine binding sites are decreased in platelets of chronic pain patients.
abstract: Tritiated imipramine binding to whole platelets was measured in sixteen chronic pain patients not suffering from major depression and in a control group. Maximum binding was significantly lower in chronic pain patients than in the control group, whereas the binding affinity was not significantly different.
mesh_terms: D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D002908:Chronic Disease; D003866:Depressive Disorder / Q000097:blood*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000097:blood*; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D007099:Imipramine