Effect of certain trace elements on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine.
Tests have been carried out to detect inhibitory activity of various trace elements on mutagenesis induced by the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine in Salmonella typhimurium strain TA100. Selenium has been found to be most active in this regard while copper has displayed moderate inhibitory ability. The action of selenium is mediated through an interaction resulting in rapid deactivation of the carcinogen.
D003300:Copper / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D009152:Mutagenicity Tests; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D020887:Selenious Acid; D012643:Selenium / Q000494:pharmacology; D014131:Trace Elements / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology
D014131:Trace Elements; D008769:Methylnitronitrosoguanidine; D008345:Manganese; D003300:Copper; D020887:Selenious Acid; D012643:Selenium; D015032:Zinc