Plasma exchange for the management of cyclosporin A-induced hypertriglyceridemia.
The authors report a case of hypertriglyceridemia complicating the course of a patient receiving cyclosporin A after bone marrow transplantation. When the patient was seen at the hemapheresis unit the clinical picture was characterized by headache, increasing visual and neurological disturbances. Plasma triglyceride level was 3215 mg/dl. Two plasma exchange sessions reduced triglycerides to 486 mg/dl and halted the disease progression. This may represent the first plasma exchange treatment of cyclosporin A-induced hypertriglyceridemia.
D000328:Adult; D016026:Bone Marrow Transplantation; D003524:Cyclosporins / Q000009:adverse effects*; D006801:Humans; D006949:Hyperlipidemias / Q000628:therapy*; D007951:Leukemia, Myeloid / Q000628:therapy; D008297:Male; D010951:Plasma Exchange; D010956:Plasmapheresis; D014280:Triglycerides / Q000097:blood*
D003524:Cyclosporins; D014280:Triglycerides