[Gene rearrangement of immunoglobulins and of the T-cell receptor for antigens and its significance in the diagnosis of lymphoproliferative diseases].
The blot-hybridization method for detecting gene rearrangement of Ig and T-cell receptor for antigen is briefly described. The results obtained by this method in various lymphoproliferative diseases offer new insights in the diagnosis of monoclonal lymphocyte expansion and in the determination of the lineage of proliferating cells. The ability of revealing oligoclonal lymphocyte proliferation and discriminating benign and malignant forms of angioimmunoblastic lymphadenopathy, T gamma-lymphocytosis, and some other disorders makes this method a useful tool for investigating diseases with lymphocyte proliferation.
D015139:Blotting, Southern; D004247:DNA / Q000235:genetics; D003937:Diagnosis, Differential; D015321:Gene Rearrangement; D015329:Gene Rearrangement, T-Lymphocyte; D005803:Genes, Immunoglobulin; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000235:genetics
D004247:DNA
Perestroĭka genov immunoglobulinov i retseptora T-kletok dlia antigena i ee znachenie v diagnostike limfoproliferativnykh zabolevaniĭ.