In vitro activity of aminopenicillins combined with sulbactam, clavulanic acid, or amdinocillin against bacteria isolated from patients with complicated urinary tract infections.
The minimal inhibitory concentrations (MICs) of ampicillin, sulbactam/ampicillin, clavulanic acid/amoxicillin, and amdinocillin/ampicillin were determined for 400 bacteria isolated from the urine of 400 urologic inpatients with complicated and/or hospital-acquired urinary tract infections (UTIs). The spectrum of isolates consisted of about one-third each of Escherichia coli, other gram-negative strains, and gram-positive strains. About one-third of all isolates were resistant to ampicillin (MICs greater than 8 micrograms/ml). Combination of an aminopenicillin with a beta-lactamase inhibitor improved the activity of the aminopenicillin against gram-negative as well as gram-positive strains. The combination of ampicillin with amdinocillin improved the activity of ampicillin against gram-negative strains only. If the total antibacterial spectrum is considered, the improvements in activity provided by the three combinations were quite similar.
D000560:Amdinocillin / Q000494:pharmacology; D000658:Amoxicillin / Q000494:pharmacology; D000667:Ampicillin / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology*; D004338:Drug Combinations; D004926:Escherichia coli / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D010397:Penicillanic Acid / Q000494:pharmacology*; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D013407:Sulbactam; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology*; D065093:beta-Lactamase Inhibitors
D002969:Clavulanic Acids; D004338:Drug Combinations; D010406:Penicillins; D065093:beta-Lactamase Inhibitors; D019818:Clavulanic Acid; D000667:Ampicillin; D000658:Amoxicillin; D010397:Penicillanic Acid; D013407:Sulbactam; D000560:Amdinocillin