[Analysis of the effect of noradrenaline on the response of the vas deferens of the rat to transmural stimulation].
In the rat isolated vas deferens, exogenous noradrenaline (NA) in concentrations of 5 X 10(-7)-5 X 10(-6) M acting for 10-15 min produced an increase whereas in concentrations above 10(-5) M it produced a decrease of the response to transmural stimulation: the increase being due to raising of the level of its secretion produced by accumulation of NA in nerve endings as well as to augmentation of postsynaptic response to NA resulting from a decrease in its reversal neuronal uptake. The decrease in the organ response to stimulation under the effect of NA at concentrations above 1 X 10(-5) M is due to desensitization of postsynaptic alpha-adrenoceptors.
D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D009451:Neuroeffector Junction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects*
D011941:Receptors, Adrenergic; D009638:Norepinephrine
Analiz vliianiia noradrenalina na reaktsiiu semiavynosiashchego protoka krysy pri transmural'noĭ stimuliatsii.