Increase in IP3 precedes alpha-adrenoceptor-induced increase in force of contraction in cardiac muscle.
In electrically driven left auricles isolated from rat hearts the alpha 1-adrenoceptor agonist phenylephrine increased inositol trisphosphate (IP3) and force of contraction. The increase in IP3 preceded the increase in force of contraction, indicating that the alpha 1-adrenoceptor-mediated increase in IP3 and force of contraction may have been causally related.
D000818:Animals; D004558:Electric Stimulation; D006321:Heart / Q000502:physiology; D066298:In Vitro Techniques; D015544:Inositol 1,4,5-Trisphosphate; D007295:Inositol Phosphates / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*
D007295:Inositol Phosphates; D011942:Receptors, Adrenergic, alpha; D015544:Inositol 1,4,5-Trisphosphate