Differentiation induction therapy of acute myelogenous leukaemias.
This article reviews the progress achieved in the field of inducing differentiation in human myeloid leukaemia in vitro and the need for applying this model in leukaemia therapy in vivo. The pre-clinical evaluation of differentiating agents in human myeloid leukaemia is analysed. The clinical experience with differentiation induction therapy in acute myeloid leukaemia is reviewed. This review examines the prospective application of this new form of therapy in patients with acute myeloid leukaemia.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002454:Cell Differentiation / Q000187:drug effects; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents