Naloxone attenuates augmentation of cAMP levels and arrhythmias following myocardial ischaemia and reperfusion in the isolated perfused rat heart.
The effects of myocardial ischaemia and reperfusion on arrhythmias and cAMP levels were studied using the Langendoff isolated perfused rat heart preparation. Myocardial ischaemia and reperfusion caused arrhythmias and augmentation of cAMP levels concurrently, supporting the suggestion that myocardial cAMP is related to arrhythmias. Pretreatment with naloxone attenuated both arrhythmias and augmentation of cAMP levels to a similar extent. The results suggest that the anti-arrhythmic effect of naloxone may involve myocardial cAMP.
D000818:Animals; D000889:Anti-Arrhythmia Agents; D003327:Coronary Disease / Q000188:drug therapy*; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D009206:Myocardium / Q000378:metabolism*; D009270:Naloxone / Q000494:pharmacology*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D000889:Anti-Arrhythmia Agents; D009270:Naloxone; D000242:Cyclic AMP