Differences in interferon-gamma response of psoriatic lymphocytes to stimulation with various mitogens.
Upon ConA stimulation, peripheral blood mononuclear leukocytes from psoriatic patients show an impaired IFN-gamma production. Normal IFN-gamma values were obtained, however, with PHA or PWM as inducers. Moreover, psoriatic cells responded well to vesicular stomatitis virus as inducer of IFN-alpha. Thus, the defect is not an all-out inability of all lymphocytes to produce IFN, but rather a failure to respond to weak mitogenic stimuli. Possible mechanisms are discussed.
D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000276:immunology*; D008934:Mitogens; D011565:Psoriasis / Q000276:immunology*; D012016:Reference Values; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D008934:Mitogens; D007371:Interferon-gamma