Effects of ethanol on the activity of brain enzymes.
Ethanol alters, in a selective manner, the activity of several membrane-bound enzymes in the central nervous system (CNS) which are important for neuronal transmission of information. Ethanol inhibits Na+/K+-transporting ATPase activity, while adenylate cyclase (AC) activity is stimulated by ethanol added in vitro. Ethanol's effects on AC activity are mediated primarily via effects on proteins that regulate AC activity. Ethanol has selective effects on monoamine oxidase activity, in that the B form of the enzyme is more sensitive to inhibition by ethanol added in vitro. The selective effects of ethanol on different membrane-bound CNS enzymes may result from differing membrane lipid microenvironments of the enzymes, or from differences in the enzyme proteins per se.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D004789:Enzyme Activation; D000431:Ethanol / Q000494:pharmacology*; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D008560:Membrane Fluidity / Q000187:drug effects; D008566:Membranes / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; D000431:Ethanol; D008995:Monoamine Oxidase; D000262:Adenylyl Cyclases; D000254:Sodium-Potassium-Exchanging ATPase