[Do imipenem and cilastatin interfere with the determination of serum creatinine?].
Some cephalosporin antibiotics increase the concentration of serum creatinine. This phenomenon could be due to the interference on the method of dosage, in particularly when the Jaffé reaction is used. This interaction could be present with imipenem, an antibiotic of thienamycins group having a chemical structure similar to that of cephalosporins, (associated with cilastatin in the tienam), in which we find the structure common to creatinine (Formula: see text) considered to be responsible of this interference. Our work indicates that with serum concentration of 100 mg/l, superior to those obtained in therapeutic, neither imipenem nor cilastatin interact on the creatinine dosage using either the Jaffé reaction of the enzymatic technic.
D001322:Autoanalysis / Q000379:methods; D015377:Cilastatin; D003404:Creatinine / Q000097:blood*; D003521:Cyclopropanes / Q000494:pharmacology*; D004150:Dipeptidases / Q000037:antagonists & inhibitors*; D006801:Humans; D015378:Imipenem; D007202:Indicators and Reagents; D013845:Thienamycins / Q000494:pharmacology*
D003521:Cyclopropanes; D007202:Indicators and Reagents; D013845:Thienamycins; D015377:Cilastatin; D015378:Imipenem; D003404:Creatinine; D004150:Dipeptidases
L'imipénème et la cilastatine interfèrent-ils sur le dosage de la créatinine sérique?