title: Histone gene stability during cellular senescence.
abstract: The extent to which human histone gene organization is conserved during the in vitro lifespan of human diploid fibroblast-like cells was determined by comparing the restriction patterns of a human H4 and an H3 histone gene from cells of various in vitro ages. No age related change in the organization of these two genes was detected.
mesh_terms: D000375:Aging / Q000235:genetics*; D002460:Cell Line; D004247:DNA / Q000032:analysis*; D004262:DNA Restriction Enzymes; D005796:Genes; D006657:Histones / Q000235:genetics*; D006801:Humans; D009693:Nucleic Acid Hybridization
chemical_list: D006657:Histones; D004247:DNA; D004262:DNA Restriction Enzymes