Isolation of human immunodeficiency virus from a Japanese hemophilia B patient with AIDS.
Human immunodeficiency virus (HIV) was isolated from a Japanese hemophilia B patient with AIDS. This isolate, HIV[GUN-1], was infectious to several mature T-cell lines. Proteins with apparent molecular weights of 160, 55 and 25 kilodaltons were detected. Restriction enzyme cleavage patterns of the proviral genome indicated that HIV[GUN-1] is related to but clearly different from HTLV-III or ARV-2.
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology / Q000382:microbiology*; D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000235:genetics; D006678:HIV / Q000145:classification / Q000302:isolation & purification*; D002836:Hemophilia B / Q000150:complications* / Q000382:microbiology; D006801:Humans; D008297:Male; D008970:Molecular Weight; D012191:Retroviridae Proteins / Q000032:analysis; D013601:T-Lymphocytes / Q000382:microbiology
D000956:Antigens, Viral; D004279:DNA, Viral; D012191:Retroviridae Proteins; D004262:DNA Restriction Enzymes