Carcinoid syndrome and disorders of systemic mast-cell activation including systemic mastocytosis.
Diagnostic approaches, clinical characteristics, and (briefly) therapy of the carcinoid syndrome and disorders of systemic mast cell activation are outlined. Mediators responsible for the humoral manifestations of the two syndromes are discussed. Because some of the clinical features of both disorders are similar (in particular, flushing), specific attention is given to the clinical differentiation of these disorders.
D006801:Humans; D008303:Malignant Carcinoid Syndrome / Q000175:diagnosis*; D008407:Mast Cells / Q000502:physiology; D008415:Mastocytosis / Q000175:diagnosis*