[Course of pregnancy and labor following cytostatic treatment of trophoblastic tumors].
In our department 24 patients underwent treatment of invasive trophoblastic tumours from 1975 to 1984. In 13 cases we were dealing with invasive bladder moles and in 11 cases with chorionic carcinoma. Nine women became pregnant, among them one case of chorionic carcinoma. Eight women were delivered of a viable child on average 30 months after the end of the treatment, whereas one patient wanted termination of pregnancy. Six women had undergone a methotrexate monotherapy before, two women a sequential treatment with methotrexate + actinomycine D. The undisturbed pregnancies and births of eight healthy babies point to an unimpaired fertility after chemotherapy of trophoblastic tumours.
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D007744:Obstetric Labor Complications / Q000139:chemically induced*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D014328:Trophoblastic Neoplasms / Q000188:drug therapy*; D014594:Uterine Neoplasms / Q000188:drug therapy*
D006063:Chorionic Gonadotropin; D008727:Methotrexate
Schwangerschaftsverlauf und Geburt nach zytostatischer Behandlung von Throphoblasttumoren.