title: B-raf, a new member of the raf family, is activated by DNA rearrangement.
abstract: Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.
mesh_terms: D001483:Base Sequence; D002461:Cell Line, Transformed; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008969:Molecular Sequence Data; D011494:Protein Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000032:analysis / Q000235:genetics*; D019908:Proto-Oncogene Proteins c-raf; D012512:Sarcoma, Ewing / Q000032:analysis
chemical_list: D011518:Proto-Oncogene Proteins; D004247:DNA; D011494:Protein Kinases; D019908:Proto-Oncogene Proteins c-raf