Enhanced reactivation of ultraviolet-irradiated human cytomegalovirus in normal host cells.
Enhanced survival of UV-irradiated human cytomegalovirus (HCMV) is demonstrated in normal human cells exposed to UV light prior to infection. The UV fluence that gave rise to maximum UV reactivation falls in the range of 15 J/m2. A large number of temperature-sensitive HCMV mutants were found under the peak of reactivation. These results confirm the existence of inducible SOS functions in human cells.
D002460:Cell Line; D003587:Cytomegalovirus / Q000235:genetics / Q000502:physiology* / Q000528:radiation effects; D004249:DNA Damage; D004279:DNA, Viral / Q000378:metabolism / Q000528:radiation effects; D004255:Deoxyribodipyrimidine Photo-Lyase / Q000378:metabolism; D004790:Enzyme Induction / Q000528:radiation effects; D005347:Fibroblasts / Q000201:enzymology / Q000528:radiation effects; D006801:Humans; D013014:SOS Response, Genetics / Q000528:radiation effects; D014466:Ultraviolet Rays; D014775:Virus Activation / Q000528:radiation effects*
D004279:DNA, Viral; D004255:Deoxyribodipyrimidine Photo-Lyase