title: Neuropsychiatric lupus.
abstract: Neuropsychiatric abnormalities in patients with systemic lupus have been recognized for more than a century. Although the prognosis of lupus has improved, involvement of the nervous system continues to be a major feature, with some abnormality recognized in 50 to 66 per cent of lupus patients. Diagnosis and therapy of neurologic disease remain the most difficult clinical challenges in the management of SLE.
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001323:Autoantibodies / Q000502:physiology; D001696:Biomechanical Phenomena; D001777:Blood Coagulation; D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D004569:Electroencephalography; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008279:Magnetic Resonance Imaging; D001523:Mental Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D014657:Vasculitis / Q000150:complications
chemical_list: D000925:Anticoagulants; D001323:Autoantibodies; D007166:Immunosuppressive Agents