title: [Natural substances regulating fertility. Effect of plant extracts in the Ivory Coast pharmacopoeia on the release of LH by hypophyseal cells in culture].
abstract: The in vitro action of hydro-alcoholic extracts of plants from Ivory Coast pharmacopoeia was analyzed on cultured rat pituitary cells. Cells were treated for 24 hours with various doses of extracts and then stimulated for 4 hours with 10(-8) M LHRH. Extracts from Afrormosia laxiflora, Cola nitida, Pterocarpus erinaceus and Tetrapleura tetraptera inhibit the LHRH-induced release of LH. On the contrary, extract from Combretodendron africanum stimulates the basal release of LH and this increase is added to the LHRH-induced release. Therefore, the natural substances contained in these plants may in vitro exert a regulation of the gonadotropin release.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D007560:Cote d'Ivoire; D005298:Fertility; D007986:Luteinizing Hormone / Q000378:metabolism*; D010602:Pharmacopoeias as Topic; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D013045:Species Specificity
chemical_list: D010936:Plant Extracts; D007986:Luteinizing Hormone
vernacular_title: Substances naturelles régulatrices de la fécondité. Action d'extraits de plantes issues de la pharmacopée ivoirienne sur la libération de LH par des cellules hypophysaires en culture.