Difference in response of vascular angiotensin converting enzyme activity to cilazapril in SHR.
Angiotensin I converting enzyme (ACE) activity was found in all rat arteries and veins examined, considerably varied among these vessels, and usually higher in arteries than in corresponding veins except for femoral and subclavian pairs. Decrease of vascular ACE activity in response to cilazapril at hypotensive doses varied in vessels and was not dependent on their ACE activity levels.
D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D001808:Blood Vessels / Q000201:enzymology*; D017315:Cilazapril; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011724:Pyridazines / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D000806:Angiotensin-Converting Enzyme Inhibitors; D011724:Pyridazines; D017315:Cilazapril; D007703:Peptidyl-Dipeptidase A