title: Suppression by perchlorate of technetium-99m and iodine-123 secretion in milk of lactating goats.
abstract: Lactating goats were infused with either technetium-99m (99mTc) or iodine-123 (123I) together with chlorine-36 (36Cl) through an indwelling catheter previously placed in an external pudic mammary artery. The radioisotope infusions were repeated together with 100 mg of sodium perchlorate. There was a rapid transfer of 99mTc and 123I into milk, reaching a peak concentration 30 min after a 15-min infusion. The fractional secretion of 99mTc and 123I in milk was reduced by 70%-80% and 60%-66%, respectively, by perchlorate. The fractional secretion of 36Cl was not affected by perchlorate, and the shape of the 36Cl secretion curve differed from those of 99mTc and 123I, which were similar. It is probable, therefore, that the latter nuclides were secreted by a transport route different from that of chloride. Available data describing the secretion of 99mTc in human milk after pertechnetate administration was reviewed, and it was concluded that perchlorate pretreatment significantly reduced the secretion of 99mTc in human breast milk.
mesh_terms: D000818:Animals; D003864:Depression, Chemical; D005260:Female; D006041:Goats; D007261:Infusions, Intra-Arterial; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000378:metabolism*; D007774:Lactation; D008323:Mammary Arteries; D008892:Milk / Q000378:metabolism*; D010472:Perchlorates / Q000494:pharmacology*; D011247:Pregnancy; D017670:Sodium Compounds; D013667:Technetium / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D007457:Iodine Radioisotopes; D010472:Perchlorates; D017670:Sodium Compounds; D013667:Technetium; C031068:sodium perchlorate