title: The plasma clearance rate of 131I-insulin in diabetic and obese patients and healthy persons.
abstract: The plasma clearance rate of 131I-insulin was studied in diabetic and obese patients and healthy persons. The aim of the investigation was to find out whether an accelerated degradation of insulin-probably due to the metabolism of insulin by adipocytes-causes slight forms of the diabetic syndrome. For the evaluation of the data a three-compartment model was used whereby the third compartment reflects the degradation of the intravenously administered 131I-insulin in the tissue. In this compartment 131I-insulin has a half life of 38.7 +/- 7.0 min for control persons (n = 19), 47.4 +/- 27.4 min for patients with a latent diabetes mellitus (n = 7), 34.2 +/- 8.5 min for the group with the subclinical diabetes (n = 5) and 47.6 +/- 16.2 min for the patients with an onset diabetes mellitus (n = 5). No significant difference was observed in the plasma clearance rate between healthy and diabetic persons. There is also no detectable correlation between the grade of obesity and the insulin clearance rate.
mesh_terms: D003920:Diabetes Mellitus / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D007328:Insulin / Q000493:pharmacokinetics; D007457:Iodine Radioisotopes; D008297:Male; D008657:Metabolic Clearance Rate; D009765:Obesity
chemical_list: D007328:Insulin; D007457:Iodine Radioisotopes