Psychiatric side effects during the treatment of Parkinson's disease.
Dopaminergic agents including both levodopa and direct-acting agonists induce a variety psychiatric side-effects of which psychosis is the most significant. When this occurs early in the course of treatment, there is usually a history of prior psychotic illness. Chronic treatment can, however, elicit psychosis in individuals without such a history. The possible pathogenesis of this is reviewed.
D004325:Dreams; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D001523:Mental Disorders / Q000139:chemically induced* / Q000523:psychology; D010259:Paranoid Disorders / Q000139:chemically induced; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D012701:Serotonin / Q000502:physiology; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000139:chemically induced
D012701:Serotonin; D007980:Levodopa