Hepatocarcinoma in a child with the Alagille syndrome.
A child with the Alagille syndrome of intrahepatic bile duct paucity developed hepatocarcinoma. Disabling cirrhosis had rendered this child a suitable candidate for transplantation before the discovery of carcinoma. However, the extension of the tumor outside the liver precluded the performance of this potentially life-saving operation. Serial monitoring of the serum alpha-fetoprotein concentration may be of value in the early identification of tumors in pediatric candidates for transplantation.
D000015:Abnormalities, Multiple / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic / Q000002:abnormalities*; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D002675:Child, Preschool; D002780:Cholestasis, Intrahepatic / Q000151:congenital* / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology*; D013577:Syndrome