[Separation of [Rh-103m]-rhodocene derivatives from the parent [103Ru]ruthenocene derivatives and their organ distribution].
The radioactive decay of [103Ru]ruthenocene derivatives leads to 103mRh labelled rhodocinium derivatives, which can be separated by the extraction of a lipophilic solution of the ruthenocen derivate with water. The separation factor 103mRh/103Ru reaches values of 32:1 Rh3+ ions are not liberated and extracted. The organ distribution of the 103mRh labelled rhodocinium derivatives gained from ruthenocene and from N-isopropyl-ruthenocene amphetamine is different from the distribution of the parent ruthenocene compound. The liver and kidney uptake of the rhodocinium-amphetamine is much higher than the uptake with ruthenocene amphetamine.
D000818:Animals; D005260:Female; D051379:Mice; D009942:Organometallic Compounds / Q000302:isolation & purification* / Q000378:metabolism; D011868:Radioisotopes / Q000302:isolation & purification* / Q000378:metabolism; D012238:Rhodium / Q000302:isolation & purification* / Q000378:metabolism; D012428:Ruthenium / Q000302:isolation & purification* / Q000378:metabolism; D014018:Tissue Distribution
D009942:Organometallic Compounds; D011868:Radioisotopes; C016721:ruthenocene; D012428:Ruthenium; D012238:Rhodium
Abtrennung von [103mRh]Rhodocen-Derivaten von den analogen [103Ru]Ruthenocen-Derivaten und deren Organ-Verteilung.