title: A critical role for ACAID in the distinctive pattern of retinitis that follows anterior chamber inoculation of HSV-1.
abstract: To test the hypothesis that ACAID induction is instrumental in producing the distinctive pattern of retinal pathology that follows anterior chamber inoculation of HSV-1 in BALB/c mice, panels of mice received uniocular anterior chamber, uniocular intravitreal, and bilateral anterior chamber inoculations of HSV-1. It was found that contralateral retinitis developed after the first two routes, and ACAID was induced by all three. Enucleation of eyes inoculated with HSV-1 before 3 days post-inoculation (but not thereafter) prevented both ACAID and contralateral retinitis. Intracameral inoculations of HSV-2 induced vigorous delayed hypersensitivity and failed to incite contralateral retinitis. It is concluded that ACAID induction plays a crucial role in the pathogenesis of contralateral retinitis following anterior chamber inoculation of HSV-1.
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000276:immunology*; D005260:Female; D007154:Immune System Diseases / Q000276:immunology*; D007635:Keratitis, Dendritic; D051379:Mice; D008807:Mice, Inbred BALB C; D012173:Retinitis / Q000209:etiology* / Q000276:immunology; D018139:Simplexvirus / Q000235:genetics / Q000472:pathogenicity; D013997:Time Factors; D014774:Virulence