Chronic granulomatous disease of childhood. An unusual case of infection with Aspergillus nidulans var. echinulatus.
Aspergillus nidulans var. echinulatus was the sole agent cultured from the left lung, a paraspinal abscess, left ribs, and thoracic vertebral bodies from a patient with chronic granulomatous disease. Hyphal elements were present in histologic sections of lung, vertebral bodies, and infected ribs along with granuloma formation. The patient was treated with two debridement procedures and insertion of a Harrington rod followed by a long course of amphotericin B, flucytosine, and daily white blood cell transfusions.
D000038:Abscess / Q000209:etiology; D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000382:microbiology / Q000628:therapy; D001233:Aspergillus nidulans / Q000302:isolation & purification*; D001803:Blood Transfusion; D002675:Child, Preschool; D005437:Flucytosine / Q000627:therapeutic use; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D017708:Leukocyte Transfusion; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000382:microbiology / Q000628:therapy; D008297:Male; D013122:Spinal Diseases / Q000209:etiology; D013904:Thoracic Vertebrae
D000666:Amphotericin B; D005437:Flucytosine