title: Treatment of premenstrual mastalgia with tamoxifen.
abstract: Thirty-four women with normal menstrual cycles but suffering from severe premenstrual mastalgia were randomly treated with either tamoxifen (10 mg daily) (18 women) or placebo (16 women) from cycle day 5 to 24 for six consecutive cycles. At the end of the treatment, 89% of the tamoxifen-treated patients were free from the symptoms and the remainder experienced partial alleviation. In contrast, six patients treated with placebo showed only partial alleviation (38%) (p less than 0.001). Twelve months after the end of tamoxifen treatment, 53% of the medicated women were still free of symptoms as compared with none of the placebo-treated patients. These results suggest that tamoxifen is highly effective for the management of severe premenstrual mastalgia and should be useful for the treatment of this disorder.
mesh_terms: D000328:Adult; D001940:Breast / Q000187:drug effects*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D010146:Pain / Q000188:drug therapy*; D011293:Premenstrual Syndrome / Q000188:drug therapy*; D011897:Random Allocation; D013629:Tamoxifen / Q000008:administration & dosage*
chemical_list: D013629:Tamoxifen