title: Effects of butyric and acetic acids on acetone-butanol formation by Clostridium acetobutylicum.
abstract: The actions of butyric and acetic acids on acetone-butanol fermentation are investigated. Production of butyric and acetic acids are controlled by the extracellular concentrations of both acids: acetic acid added to the medium inhibits its own formation but has no effect on butyric acid formation, and added butyric acid inhibits its own formation but not that of acetic acid. The ratio of end metabolites depends upon acetic and butyric acid quantities excreted during the fermentation. In contrast to acetic acid, which specifically increases acetone formation, butyric acid increases both acetone and butanol formations. Acetate and butyrate kinase activities were also examined. Both increase at the start of fermentation and decrease when solvents appear in the medium. Coenzyme A transferase activity is weak in the acidogenic phase and markedly increases in the solvent phase. Acetic and butyric acids appear to be co-substrates. On the basis of these results, a mechanism of acetic and butyric acid pathways, coupled to solvent formation by C. acetobutylicum glucose fermentation is proposed.
mesh_terms: D000084:Acetate Kinase / Q000378:metabolism; D000085:Acetates / Q000494:pharmacology*; D019342:Acetic Acid; D000096:Acetone / Q000096:biosynthesis; D000440:Butanols / Q000096:biosynthesis; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D003013:Clostridium / Q000187:drug effects / Q000378:metabolism*; D003065:Coenzyme A / Q000378:metabolism; D005285:Fermentation / Q000187:drug effects*; D007700:Kinetics; D010770:Phosphotransferases / Q000378:metabolism; D017851:Phosphotransferases (Carboxyl Group Acceptor)
chemical_list: D000085:Acetates; D000440:Butanols; D002087:Butyrates; D020148:Butyric Acid; D000096:Acetone; D010770:Phosphotransferases; D017851:Phosphotransferases (Carboxyl Group Acceptor); D000084:Acetate Kinase; C019285:butyrate kinase; D019342:Acetic Acid; D003065:Coenzyme A