title: [In vivo study of the sensitivity of Treponema pallidum to ofloxacin].
abstract: Treponema pallidum has not been yet cultivated. Hence any in vitro investigation is excluded, and it is owing to the experimental animal model, the rabbit, that we have studied the susceptibility of that germ to ofloxacin. This quinolone, owing to its pharmacokinetic and therapeutic properties, can specially be indicated in the treatment of Sexually Transmitted Diseases. Thus, its appeared to be of the utmost importance to know if the suggested schedule of treatment for STD, might not be susceptible to modify the course of a co-existing incubating syphilis by either delaying or inhibiting the apparition of the clinical features of primary syphilis. This study was undertaken at the incubation period, in syphilitic rabbits, using kinetic data obtained in man, after a given dosage of ofloxacin. Results were appraised upon converging data: lesions, bacteriology, and serology of the tested lot compared with two control batches of infected rabbits, the first one being untreated, the other having received the reference antibiotic treatment. From the data obtained and in the experimental settled conditions where this study was done, it results that ofloxacin has no effect on the course of the experimental syphilitic infection.
mesh_terms: D000293:Adolescent; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D015242:Ofloxacin; D010078:Oxazines / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D010401:Penicillin G Benzathine / Q000097:blood / Q000627:therapeutic use; D010402:Penicillin G Procaine / Q000097:blood / Q000627:therapeutic use; D011817:Rabbits; D013587:Syphilis / Q000188:drug therapy*; D014210:Treponema pallidum / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D010078:Oxazines; D010402:Penicillin G Procaine; D015242:Ofloxacin; D010401:Penicillin G Benzathine
vernacular_title: Etude in vivo de la sensibilité de Treponema pallidum à l'ofloxacine.