Preservation of the canine liver for 24-48 hours using simple cold storage with UW solution.
The results of a series of 29 orthotopic liver transplants in the dog are described. The livers were preserved in a new cold storage fluid, UW solution, and were successfully transplanted after periods of storage of 24, 30, 36, and 48 hr. All six animals transplanted after 24 hr survived beyond 5 days after transplantation and had excellent graft function. Four of six survived for at least 5 days after 30 hr of cold storage, and five of five after 36 hr. Five of six consecutive dogs that received transplants that had been cold-stored for 48 hr survived for 5 or more days. This solution represents a substantial advance over all existing cold storage solutions for liver preservation.
D000241:Adenosine; D000493:Allopurinol; D000818:Animals; D003080:Cold Temperature; D004285:Dogs; D005260:Female; D005978:Glutathione; D007328:Insulin; D008099:Liver / Q000033:anatomy & histology; D016031:Liver Transplantation; D008297:Male; D008954:Models, Biological; D009926:Organ Preservation; D019188:Organ Preservation Solutions; D011887:Raffinose; D012996:Solutions; D013997:Time Factors
D007328:Insulin; D019188:Organ Preservation Solutions; D012996:Solutions; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose