Interferon-alpha enhances the production of leukotriene B4 in murine peritoneal macrophages stimulated by opsonized zymosan.
Murine peritoneal macrophages pretreated with interferon (IFN)-alpha and then stimulated by opsonized zymosan produced two to three times more LTB4 than untreated macrophages. However, PGE2 production was not changed by IFN-alpha. Meanwhile, IFN-gamma did not affect the production of LTB4 and PGE2. From the results it is considered that IFN-alpha can modulate inflammation or host defence through the production of LTB4.
D000818:Animals; D015232:Dinoprostone; D005260:Female; D007370:Interferon Type I / Q000494:pharmacology*; D007975:Leukotriene B4 / Q000096:biosynthesis*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D011458:Prostaglandins E / Q000096:biosynthesis; D015054:Zymosan / Q000494:pharmacology*
D007370:Interferon Type I; D011458:Prostaglandins E; D007975:Leukotriene B4; D015054:Zymosan; D015232:Dinoprostone