Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids from Trypanosoma cruzi.
Epimastigotes of Trypanosoma cruzi (Tulahuen strain Tul 0 stock) biotransform benznidazole (N-benzyl-2-nitro-1-imidazole acetamide) to reactive metabolites that bind covalently to DNA, proteins and lipids of the parasite. These effects might be related to the trypanocidal action of benznidazole, a chemotherapeutic agent against Chagas' disease.
D000818:Animals; D002467:Cell Nucleus / Q000032:analysis; D004247:DNA / Q000378:metabolism*; D050356:Lipid Metabolism; D009593:Nitroimidazoles / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D014349:Trypanosoma cruzi / Q000032:analysis*
D009593:Nitroimidazoles; D011506:Proteins; D004247:DNA; C009999:benzonidazole