Human adult T-cell leukaemia virus (ATLV) genome codes for the protein pX27 structurally homologous to immunoglobulin-like part of HLA-DQ antigen.
Within the 3' end of nucleotide sequence of human adult T-cell leukaemia virus (ATLV) four small open frames in various phases were found previously. The frames code for 10,000-, 11,000-, 12,000- and 27,000-dalton polypeptides, one of which can be responsible for virus transforming activity. By means of methods of prediction of secondary structure from amino acid composition and sequence, the beta-pleated structure was shown to be the main conformation of the 27,000-dalton polypeptide (pX27 ATLV). As a result of fitting of beta-pleats and cysteines in the N- and C-terminal parts of pX27 ATLV to those of C gamma 2 and C gamma 3 domains of human immunoglobulins G (HuIgG) and of immunoglobulin-like domains of human major histocompatibility antigens (HLA-B, -DR, -DQ), a statistically valid homology was observed by comparing the C-terminal part of pX27 ATLV with the immunoglobulin-like domain of HLA-DQw1 antigen.
D000595:Amino Acid Sequence; D017977:Deltaretrovirus / Q000032:analysis / Q000235:genetics*; D005814:Genes, Viral; D005815:Genetic Code; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000032:analysis / Q000235:genetics*; D007074:Immunoglobulin G / Q000032:analysis / Q000145:classification; D010455:Peptides / Q000235:genetics; D011487:Protein Conformation; D012191:Retroviridae Proteins / Q000235:genetics*; D015682:Retroviridae Proteins, Oncogenic
D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D007074:Immunoglobulin G; D010455:Peptides; D012191:Retroviridae Proteins; D015682:Retroviridae Proteins, Oncogenic; C052621:px27 protein, human T cell leukemia virus type I