Inhibition of herpes simplex virus replication in the mouse cornea by drug containing immunoliposomes.
Monoclonal antibody to HSV glycoprotein D was derivatized with palmitic acid and incorporated into liposomes. These immunoliposomes bound specifically to intact mouse corneas infected with HSV-1 in vitro. Furthermore, in yield reduction assays, anti-gD immunoliposomes loaded with acyclovir proved far more effective at inhibiting viral replication in the cornea than free drug or drug delivered in untargeted liposomes. Site-specific sustained release immunoliposomes of this type are potentially an improved vehicle for drug delivery in the treatment of ocular HSV.
D000212:Acyclovir / Q000627:therapeutic use*; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D003315:Cornea / Q000382:microbiology*; D066298:In Vitro Techniques; D008081:Liposomes / Q000008:administration & dosage / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D018139:Simplexvirus / Q000276:immunology / Q000502:physiology*; D014779:Virus Replication / Q000187:drug effects*
D000956:Antigens, Viral; D008081:Liposomes; D000212:Acyclovir