The prophylactic use of polyvinylpyridine-N-oxide (PVNO) in baboons exposed to quartz dust.
Twelve baboons were exposed to a quartz dust cloud. Four of these were also given polyvinylpyridine-N-oxide (PVNO) by aerosol and four received PVNO by aerosol and injection. A prophylactic effect was demonstrated during the course of treatment, but when treatment stopped the silicosis progressed to the same degree of severity as in the untreated animals.
D000818:Animals; D003094:Collagen / Q000032:analysis; D004391:Dust / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects / Q000502:physiology; D008168:Lung / Q000032:analysis / Q000473:pathology; D008297:Male; D010215:Papio; D011144:Polyvinylpyridine N-Oxide / Q000097:blood / Q000494:pharmacology*; D011145:Polyvinyls / Q000494:pharmacology*; D011791:Quartz / Q000633:toxicity*; D012822:Silicon Dioxide / Q000032:analysis / Q000633:toxicity*; D012829:Silicosis / Q000517:prevention & control*
D004391:Dust; D011145:Polyvinyls; D011791:Quartz; D012822:Silicon Dioxide; D003094:Collagen; D011144:Polyvinylpyridine N-Oxide