Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family.
Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated alpha-subunit and beta-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.
D000818:Animals; D002417:Cattle; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005786:Gene Expression Regulation; D008565:Membrane Proteins / Q000235:genetics; D005810:Multigene Family; D009865:Oocytes / Q000502:physiology; D011487:Protein Conformation; D011963:Receptors, GABA-A / Q000235:genetics* / Q000502:physiology; D011978:Receptors, Nicotinic / Q000235:genetics; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D008565:Membrane Proteins; D011963:Receptors, GABA-A; D011978:Receptors, Nicotinic; D005680:gamma-Aminobutyric Acid; D004247:DNA