Development of adenosine 5'-triphosphate sulfurylase and adenosine phosphosulfate kinase in rat cerebrum and liver.
The development of the enzymes of sulfate activation, ATP-sulfurylase and APS-kinase has been studied in rat cerebrum and, for comparison, in rat liver as well. Cerebrum contains a species of ATP-sulfurylase which can be inhibited by phenylalanine. The activity of this form of ATP-sulfurylase is high in oligodendroglial cells and parallels the rate of myelination.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000254:growth & development; D008099:Liver / Q000201:enzymology* / Q000254:growth & development; D009713:Nucleotidyltransferases / Q000378:metabolism*; D010649:Phenylalanine / Q000494:pharmacology; D010770:Phosphotransferases / Q000378:metabolism*; D017853:Phosphotransferases (Alcohol Group Acceptor); D051381:Rats; D011919:Rats, Inbred Strains; D013430:Sulfate Adenylyltransferase / Q000378:metabolism*
D010649:Phenylalanine; D010770:Phosphotransferases; D017853:Phosphotransferases (Alcohol Group Acceptor); C019617:adenylylsulfate kinase; D009713:Nucleotidyltransferases; D013430:Sulfate Adenylyltransferase