Interleukin-1-like activity in capsular material from Haemophilus actinomycetemcomitans.
This paper describes the activity of a bacterial surface component (capsular material, CM) in biological assays for interleukin-1 (IL-1). CM from the periodontal pathogen Haemophilus actinomycetemcomitans was tested in the following in vitro assays: mouse thymocyte proliferation (LAF assay), stimulation of collagenase and prostaglandin (PG) E2 synthesis by articular chondrocytes, and stimulation of PGE2 synthesis by fibroblasts. In all these assays, CM gave a response similar to an IL-1 preparation. This ability to mimic IL-1 suggests an important role for CM in both cell-mediated immunity and connective tissue destruction in localized juvenile periodontitis (LJP).
D000818:Animals; D001681:Biological Assay; D002358:Cartilage, Articular / Q000378:metabolism; D002455:Cell Division; D002462:Cell Membrane / Q000276:immunology; D003208:Concanavalin A / Q000494:pharmacology; D015232:Dinoprostone; D005347:Fibroblasts / Q000378:metabolism; D006190:Haemophilus / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D003012:Microbial Collagenase / Q000096:biosynthesis; D011458:Prostaglandins E / Q000096:biosynthesis; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology
D007375:Interleukin-1; D011458:Prostaglandins E; D003208:Concanavalin A; D003012:Microbial Collagenase; D015232:Dinoprostone