title: The action of trimebutine maleate on gastrointestinal motility is mediated by opiate receptors in human subjects.
abstract: The effects of trimebutine on interdigestive motor activity of the small intestine and the colon were studied in healthy volunteers. Trimebutine induced in all subjects phase III-like motor complexes, which were similar to spontaneously occurring phase III complexes of the interdigestive cycle in antrum and duodenum. Trimebutine-induced complexes were suppressed by naloxone. Trimebutine and/or naloxone had no consistent effect on interdigestive contractile activity in the colon.
mesh_terms: D000328:Adult; D001565:Benzoates / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects / Q000648:ultrastructure; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007421:Intestine, Small / Q000187:drug effects / Q000648:ultrastructure; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D014287:Trimebutine / Q000037:antagonists & inhibitors / Q000494:pharmacology*
chemical_list: D001565:Benzoates; D011957:Receptors, Opioid; D009270:Naloxone; D014287:Trimebutine