title: Polymorphic human glucose transporter gene (GLUT) is on chromosome 1p31.3----p35.
abstract: The glucose transporter is a membrane glycoprotein that is involved in the uptake of glucose by most, if not all, animal cells. A cloned cDNA that encodes the human protein was used to map the gene to a specific chromosomal region and to identify a DNA polymorphism. The human gene (designated GLUT) was assigned to chromosome 1p31.3----p35 by hybridization of the probe to DNA from a panel of human-mouse somatic cell hybrids containing different human chromosomes and by in situ hybridization to isolated metaphase chromosomes. The most likely location of GLUT is in 1p33. A common two-allele restriction-fragment-length polymorphism was identified with Xba I.
mesh_terms: D002871:Chromosome Banding; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005796:Genes; D005947:Glucose / Q000378:metabolism; D006801:Humans; D009004:Monosaccharide Transport Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D009004:Monosaccharide Transport Proteins; D004247:DNA; D004262:DNA Restriction Enzymes; D005947:Glucose