Mechanisms of cellular resistance to cisplatin.
Treatment of cancer patients often fails because of the resistance in the tumor to chemotherapeutic drugs. A better understanding of mechanisms which are active in resistant cells might lead to measures to circumvent the resistance. This review deals with the mechanisms of action of cisplatin (CDDP) and the various causes for CDDP resistance in the tumor cells. Also, possibilities to circumvent CDDP resistance in vitro and in vivo are presented.
D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D002945:Cisplatin / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D003593:Cytoplasm / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism; D004351:Drug Resistance; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology
D004273:DNA, Neoplasm; D002945:Cisplatin