title: Stimulating effect of heat shock on the early stage of human cytomegalovirus replication cycle.
abstract: The effect of mild heat shock on the replication of human cytomegalovirus (HCMV) was studied in human embryo fibroblasts. Treatment of cell cultures at 44 degrees C for 10 min just before infection or at 24 h post infection (p.i.) shortened HCMV eclipse period and enhanced viral replication, while heat shock performed at 48 h p.i. had no effect on the HCMV replication cycle. Study of HCMV-induced early and late antigens confirmed that the cellular response to heat shock influences HCMV replication in the early stage of the viral replication cycle.
mesh_terms: D000956:Antigens, Viral / Q000032:analysis; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000276:immunology / Q000502:physiology*; D005347:Fibroblasts; D006358:Hot Temperature; D006801:Humans; D017874:Immediate-Early Proteins; D013997:Time Factors; D014779:Virus Replication
chemical_list: D000956:Antigens, Viral; D017874:Immediate-Early Proteins; C044582:immediate-early proteins, cytomegalovirus