Architecture of models for prebiotic synthesis of nucleic acids: template-directed synthesis of oligoguanylates using N-cyanoimidazole.
N-Cyanoimidazole is an efficient condensing agent for the polymerization of guanosine 5'-phosphate (pG) on a poly(C) template in an aqueous solution. At 0 degree C, up to about 30% of input pG was converted to a mixture of oligomers with a mean chain length of up to 7. The effect of divalent metal ions in the polymerization of pG on a poly(C) template was not so considerable as in that of oligo(A) on a poly(U) template. In the polymerization of pG, the moderate yields were obtaind in the presence of Co2+, Ni2+ and Cu2+.
D006150:Guanine Nucleotides / Q000138:chemical synthesis*; D006157:Guanosine Monophosphate; D007093:Imidazoles; D007202:Indicators and Reagents; D008957:Models, Genetic; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D011066:Poly C; D011131:Polyribonucleotides; D013698:Templates, Genetic
D006150:Guanine Nucleotides; D007093:Imidazoles; D007202:Indicators and Reagents; D009843:Oligoribonucleotides; D011131:Polyribonucleotides; C036895:oligo(G); D011066:Poly C; D006157:Guanosine Monophosphate; C051673:N-cyanoimidazole