[3H] imipramine binding sites are decreased in platelets of chronic pain patients.
Tritiated imipramine binding to whole platelets was measured in sixteen chronic pain patients not suffering from major depression and in a control group. Maximum binding was significantly lower in chronic pain patients than in the control group, whereas the binding affinity was not significantly different.
D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D002908:Chronic Disease; D003866:Depressive Disorder / Q000097:blood*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000097:blood*; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D007099:Imipramine