Malignant tumor cell lines produce interleukin-1-like factor.
Sixty-four malignant cell lines were examined for interleukin-1 (IL-1) activities in their conditioned medium using thymocyte and fibroblast proliferation assays. Sixteen cell lines showed high IL-1 activity. Comparison of these activities with human IL-1 showed similarity between some biological properties. However there was no correlation between cell origin and IL-1 activity. These results suggest the possibility that most malignant cells may produce an IL-1-like factor.
D004815:Epidermal Growth Factor / Q000494:pharmacology; D006133:Growth Substances / Q000096:biosynthesis*; D006493:Heparin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology; D013950:Thymus Gland / Q000166:cytology; D014168:Transferrin / Q000494:pharmacology; D015291:Transforming Growth Factors; D014407:Tumor Cells, Cultured / Q000378:metabolism*
D006133:Growth Substances; D007328:Insulin; D007375:Interleukin-1; D010455:Peptides; D014168:Transferrin; D004815:Epidermal Growth Factor; D015291:Transforming Growth Factors; D006493:Heparin