Resistance of multidrug-resistant lines to natural killer-like cell-mediated cytotoxicity.
Multidrug resistance (MDR) refers to a complex phenotype that describes a number of features characterized primarily by resistance to a wide range of structurally unrelated drugs. In this paper we investigated the relationship between drug resistance and resistance to NK-mediated cytotoxicity. Studies with two independently selected multidrug-resistant cell lines indicated that increased drug resistance was associated with both an increased resistance to NK-mediated cytotoxicity and increased levels of membrane P-glycoprotein expression. This resistance to cytotoxicity appears to result partly from an alteration in the membrane structure of the target cells inasmuch as there was a reduction in effector:target cell recognition. Resistance to NK-mediated cytotoxicity should be included with the numerous pleiotropic changes associated with the multidrug resistance phenotype.
D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology; D003602:Cytotoxicity, Immunologic; D004351:Drug Resistance; D007694:Killer Cells, Natural / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000378:metabolism; D010641:Phenotype
D008562:Membrane Glycoproteins