title: The gene encoding vasoactive intestinal peptide is located on human chromosome 6p21----6qter.
abstract: Vasoactive intestinal peptide (VIP) is a regulatory neuropeptide involved in a wide variety of functions, among them vasodilation, smooth muscle relaxation, sweat secretion, gastrointestinal peristalsis, and pancreatic function. A deficient VIP-innervation of sweat glands was recently described as a possible pathogenic factor in sweating of cystic fibrosis (CF) patients. To investigate a possible role for a defective VIP-gene in cystic fibrosis, we have used a panel of rodent-human hybrid cells, retaining defined complements of human chromosomes to localize the VIP-gene to the human chromosome region 6p21----6qter. As the CF gene was recently mapped to chromosome 7, we conclude that the VIP-gene is not the primary gene defect in this disease.
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D003550:Cystic Fibrosis / Q000235:genetics; D004262:DNA Restriction Enzymes; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D014660:Vasoactive Intestinal Peptide / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D014660:Vasoactive Intestinal Peptide; D004262:DNA Restriction Enzymes