Effect of gamma irradiation on membranes of normal and pathological erythrocytes (beta-thalassemia).
The influence of ionizing radiation on the membrane of human normal erythrocytes has extensively been studied and a variety of effects including changes in the cation fluxes [3, 9] or in non-electrolytes permeability [5, 6, 11], in membrane fluidity, in peroxidation of unsaturated lipids as well as chemical composition or structural modifications [4, 7, 8] has been observed. However, only few studies deal with the effects of ionizing radiation on pathological red blood cells. In this work, we have investigated by means of electron spin resonance (ESR) spectroscopy the effects of 60Co gamma-radiation on the normal and homozygous beta-thalassemic human erythrocyte membranes [12, 13].
D002463:Cell Membrane Permeability / Q000187:drug effects; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000502:physiology / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D008560:Membrane Fluidity / Q000528:radiation effects; D008563:Membrane Lipids / Q000097:blood / Q000528:radiation effects; D013789:Thalassemia / Q000097:blood*
D008563:Membrane Lipids