Genetic studies of low abundance human plasma proteins. III. Polymorphism of the C1R subcomponent of the first complement component.
Genetic polymorphism of the C1R subcomponent of human complement component C1 has been detected in normal plasma samples using the high resolving power of isoelectric focusing in 6 M urea followed by immunoblotting. There are two common alleles at the C1R structural locus that show autosomal codominant inheritance. The C1R*1 and C1R*2 allele frequencies in U.S. white and U.S. black blood donors are: .934, .066, and .899, .101, respectively.
D000483:Alleles; D044383:Black People; D001798:Blood Proteins / Q000235:genetics*; D003166:Complement Activating Enzymes / Q000235:genetics*; D003172:Complement C1 / Q000235:genetics*; D015923:Complement C1r; D005787:Gene Frequency; D005796:Genes; D006801:Humans; D007525:Isoelectric Focusing; D011110:Polymorphism, Genetic; D044465:White People
D001798:Blood Proteins; D003172:Complement C1; D003166:Complement Activating Enzymes; D015923:Complement C1r