More than one DNA sequence encodes the 2''-O-adenylyltransferase phenotype.
Biochemical and phenotypic assays indicate that three enterobacterial R plasmids isolated in a single hospital encode 2''-O-adenylyltransferase [ANT(2'')], and an ANT(2'')-specific probe was developed from one plasmid. Southern hybridization revealed the three plasmids to be unrelated and, further, showed their ANT(2'')-encoding genes to be different.
D001426:Bacterial Proteins / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics*; D004755:Enterobacteriaceae / Q000235:genetics* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D005796:Genes; D005798:Genes, Bacterial; D006801:Humans; D009710:Nucleotide Mapping; D009713:Nucleotidyltransferases / Q000235:genetics*; D010641:Phenotype; D011815:R Factors; D012689:Sequence Homology, Nucleic Acid
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D009713:Nucleotidyltransferases; C020565:gentamicin 2''-nucleotidyltransferase