title: The pattern of methylation in rearranged and germ-line human immunoglobulin constant mu genes.
abstract: Human C mu genes show two different patterns of demethylation. The first is associated with gene expression; this pattern is restricted to productive C mu alleles and is detected in leukemic and normal B-lymphocytes but not in T-lymphocytes, granulocytes or fibroblasts. The second pattern, not related with gene expression, is observed in B-lymphocytes, fibroblasts and part of T-lymphocytes but not in granulocytes.
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005347:Fibroblasts / Q000276:immunology; D005786:Gene Expression Regulation; D014644:Genetic Variation; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007127:Immunoglobulin Constant Regions / Q000235:genetics*; D007148:Immunoglobulin mu-Chains / Q000235:genetics*; D007136:Immunoglobulins / Q000235:genetics*; D007938:Leukemia / Q000276:immunology; D008745:Methylation; D009693:Nucleic Acid Hybridization; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007127:Immunoglobulin Constant Regions; D007148:Immunoglobulin mu-Chains; D007136:Immunoglobulins; D004247:DNA; D004262:DNA Restriction Enzymes