Complex viral and fungal skin lesions of patients with acquired immunodeficiency syndrome.
Three patients with acquired immunodeficiency syndrome were noted to have skin lesions in which there were histologic changes supporting the presence of both fungal and viral pathogens. Skin lesions were found in the patellar region in two patients and in the groin in one patient. Skin biopsies revealed massive epidermal hyperplasia, cytopathic changes of herpesvirus infection in all three patients, papillomavirus in one patient, and septate hyphae in the stratum corneum in all patients. The coexistence of fungal and viral infection produces an epidermal response that in some features resembles that seen in keratoacanthoma.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D003881:Dermatomycoses / Q000209:etiology*; D006561:Herpes Simplex / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae; D012867:Skin / Q000473:pathology; D014412:Tumor Virus Infections / Q000209:etiology*