title: Aspirin-induced gastroduodenal injury and its prevention by prostaglandins.
abstract: It appears likely that aspirin injury and thus bleeding is due to both inhibition of the mucosal synthesis of protective endogenous prostanoids and to a local irritant effect. This injury can be abolished in humans by acid-inhibitory doses of prostaglandins and can probably be ameliorated by 'cytoprotective' doses. It has yet to be shown that the gastropathy seen in patients taking long-term aspirin-like drugs can be prevented or treated by prostaglandins. The clinical relevance of such protection has not yet been established.
mesh_terms: D000818:Animals; D001241:Aspirin / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D005753:Gastric Mucosa / Q000187:drug effects; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects; D011453:Prostaglandins / Q000627:therapeutic use*; D051381:Rats
chemical_list: D011453:Prostaglandins; D001241:Aspirin