Dipyrone versus paracetamol: a double-blind study in typhoid fever.
In a double-blind study in patients with typhoid fever 25 patients received 500 mg dipyrone and 28 received 500 mg paracetamol. Rectal temperature and pulse records were monitored every 30 min. The onset of anti-pyresis in patients given dipyrone (30 min) was significantly different from those given paracetamol (1 h). The area under the time-temperature curves was significantly greater for patients given dipyrone. The sum of the reduction in temperature at all times significantly favoured patients who had been given dipyrone. Both treatments were well tolerated.
D000082:Acetaminophen / Q000627:therapeutic use*; D000328:Adult; D000632:Aminopyrine / Q000031:analogs & derivatives*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001831:Body Temperature / Q000187:drug effects; D002986:Clinical Trials as Topic; D004177:Dipyrone / Q000627:therapeutic use*; D004311:Double-Blind Method; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D012007:Rectum; D013997:Time Factors; D014435:Typhoid Fever / Q000188:drug therapy* / Q000503:physiopathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000632:Aminopyrine; D000082:Acetaminophen; D004177:Dipyrone