Atypical cutaneous fibrous histiocytoma.
We report seven cases of atypical cutaneous fibrous histiocytoma, which appears to be a variant of cutaneous fibrous histiocytoma (dermatofibroma). These patients are all middle-aged women (mean, 39 years old) with small nodules occurring on the trunk and limbs. The lesions are characterized by marked focal cellular atypia, the absence of mitoses, and xanthomatous changes in both mononuclear and giant cells--all found within a small dermal nodule (approximately 1 cm) separated from an acanthotic epidermis by a Grenz zone. Their benign nature is demonstrated by the absence of recurrence, even after 9 years follow-up time.
D000328:Adult; D005260:Female; D005350:Fibroma / Q000473:pathology; D005500:Follow-Up Studies; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology*