title: Fat induced hypertension in rabbits: the effects of dietary linoleic and linolenic acid.
abstract: It has been suggested that dietary linoleic and gamma-linolenic acid may be hypotensive. Fat enriched diets increase blood pressure, and the effects of linoleic and linolenic acids on this increase have been investigated. After a control period on a low fat diet, rabbits were given four fat enriched diets containing different proportions of linoleic, gamma-linolenic and alpha-linolenic acids for 8 weeks, and returned to the low fat control diet for 3 weeks. Blood pressures were measured non-invasively every day. Blood pressures increased from the 4th week of fat feeding. The blood pressure increase at 8 weeks was 10%, 13%, 15% and 14% respectively for primrose, starflower, safflower and olive oils (all P less than 0.001). Return to the low fat control diet for 3 weeks restored blood pressures to near control values. These results do not support the suggestion that either linoleic or gamma-linolenic acids are effective antihypertensive agents.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004041:Dietary Fats; D006973:Hypertension / Q000139:chemically induced* / Q000188:drug therapy; D008041:Linoleic Acids / Q000627:therapeutic use*; D008042:Linolenic Acids / Q000627:therapeutic use*; D010938:Plant Oils; D011817:Rabbits; D017965:gamma-Linolenic Acid
chemical_list: D004041:Dietary Fats; D008041:Linoleic Acids; D008042:Linolenic Acids; D010938:Plant Oils; D017965:gamma-Linolenic Acid