title: The inflammatory reaction to crystals.
abstract: Acute gout serves as a relatively well-defined paradigm for the review of the pathogenesis of acute microcrystal-induced inflammation. Inflammatory mediator systems activated directly or indirectly by urate crystals, the temporal events in a gouty paroxysm, and the possible factors responsible for the wide clinical variability of acute gout and other forms of crystal-induced inflammation are discussed.
mesh_terms: D000917:Antibody Formation; D015210:Arthritis, Gouty / Q000209:etiology / Q000503:physiopathology; D002462:Cell Membrane / Q000502:physiology; D003460:Crystallization; D003461:Crystallography; D006073:Gout / Q000209:etiology* / Q000276:immunology; D006801:Humans; D014527:Uric Acid / Q000276:immunology / Q000502:physiology*
chemical_list: D014527:Uric Acid