Retrovirus antigens recognized by cytolytic T lymphocytes activate tumor rejection in vivo.
We have initiated the molecular definition of the antigens recognized by Gross MuLV-specific cytolytic T lymphocytes on the surface of Gross MuLV-induced tumor cells. A panel of target cells was obtained by the double transfection and expression of a retrovirus gene and a foreign H-2 gene in recipient mouse fibroblasts. Our results show that class I H-2 transplantation antigens have a directive influence in determining the antigenicity of proteins encoded by the gag and env MuLV genes. Genes not linked to H-2 influence the intensity and the specificity of the cytolytic T lymphocyte response to Gross MuLV-induced tumors. Finally, MuLV-induced antigens expressed by transfected fibroblasts induce tumor immunity and lead to accelerated tumor rejection in vivo.
D000406:AKR murine leukemia virus / Q000235:genetics / Q000276:immunology*; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D015683:Gene Products, gag; D005814:Genes, Viral; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology; D009052:Leukemia Virus, Murine / Q000276:immunology*; D007942:Leukemia, Experimental / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D012191:Retroviridae Proteins / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014162:Transfection; D014759:Viral Envelope Proteins / Q000276:immunology
D000956:Antigens, Viral; D015683:Gene Products, gag; D006183:H-2 Antigens; D012191:Retroviridae Proteins; D014759:Viral Envelope Proteins