title: Effect of acyclovir on the replication of turkey herpesvirus and Marek's disease virus.
abstract: The toxicity of acyclovir for chick embryo fibroblasts and its effect on the replication of turkey herpesvirus (strain FC 126) and Marek's disease virus (strain HPRS 16) multiplied on fibroblast culture was studied. The influence of using acyclovir on the development of the tumour process in birds infected with a virulent Marek's disease virus was also determined. Acyclovir used in doses below 12.5 micrograms ml-1 proved to be nontoxic for chick embryo fibroblast culture. It inhibited in vitro replication of turkey herpesvirus and Marek's disease virus. It was also shown to diminish the development of tumours in birds infected with Marek's disease virus.
mesh_terms: D000212:Acyclovir / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D002645:Chickens; D005347:Fibroblasts; D006564:Herpesviridae / Q000187:drug effects*; D008381:Herpesvirus 2, Gallid / Q000187:drug effects*; D008380:Marek Disease / Q000188:drug therapy; D014766:Viremia / Q000188:drug therapy / Q000662:veterinary; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000212:Acyclovir