Effect of a high carbohydrate diet on cardiac alpha-1 and beta adrenoceptors.
Short-term (2 weeks) administration of a high-fructose diet to euthyroid Sprague-Dawley rats results in a significant (18%) increase of cardiac beta-adrenoceptors without any change in their affinities or their distribution between the plasma membrane and a vesicular fraction. A much smaller increase occurs in the number of alpha 1-adrenoceptors (8% higher than in rats fed a regular diet). The high-carbohydrate diet induced a 39% increase in beta-adrenoceptor numbers/heart in hypothyroid animals and a 19% increase in the total number of alpha 1-adrenoceptors. These results strongly suggest that changes in cardiac performance after dietary manipulations may be mediated, in part, through enhancement of adrenergic pathways.
D000818:Animals; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D005632:Fructose / Q000008:administration & dosage; D007037:Hypothyroidism / Q000378:metabolism; D007700:Kinetics; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013347:Subcellular Fractions / Q000378:metabolism
D004040:Dietary Carbohydrates; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D005632:Fructose