Hyperresponsiveness of arterial rings induced by renal prehypertensive rabbit plasma.
Vascular rings from normal rabbit renal arteries, when bathed in processed plasma from 3-day renal artery stenosis (RAS) rabbits, had greater contractile responses to norepinephrine than did matched rings bathed in processed plasma from sham-operated rabbits. This vascular hyperresponsiveness of the rings produced by 3-day RAS plasma was abolished by the angiotensin II (ANG II) antagonist [Sar1, Ile8] ANG II but not by [Sar1, Ala8] ANG II at a dose that completely blocked the contractile responses of the rings to ANG II. The addition of [Sar1, Ala8]-ANG II to rings bathed in normal rabbit plasma did not alter the contractile responses to norepinephrine, indicating a lack of agonistic action by this ANG II analogue. These studies demonstrated that the ANG II receptors involved in the hormonally mediated vascular hyperresponsiveness in 3-day RAS rabbits are contained in the tissues that comprise these renal arterial rings.
D015059:1-Sarcosine-8-Isoleucine Angiotensin II / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure; D006977:Hypertension, Renal / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D012016:Reference Values; D012077:Renal Artery / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D012083:Renin / Q000097:blood; D012504:Saralasin / Q000031:analogs & derivatives / Q000494:pharmacology
D000804:Angiotensin II; C027590:angiotensin II, 1-Sar-5-Ile-8-Ala-; D015059:1-Sarcosine-8-Isoleucine Angiotensin II; D012083:Renin; D012504:Saralasin; D009638:Norepinephrine