[Effect of amizil and the ACTH4-10 fragment on the ability of mice to extrapolate the direction of movement].
Mice possessing the ability to extrapolate the direction of movement (100% of correct choices) were injected i.p. with different doses of m-cholinolytic amizil 2 hours before experiment. Doses of 2-5 mg/kg reduced the percentage of correct choices, the adequate solving strategy being replaced by stereotyped unidirectional reactions or stereotyped alternating responses. Doses of 8-12 mg/kg induced "refusals" to solve extrapolation problem. When amizil treated mice were intraventricularly injected with 1 mg/kg of ACTH4-10, their extrapolation ability was restored. This compensatory action of peptide could be mediated by its influence on cholinergic as well as on other neurotransmitter systems.
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001535:Benactyzine / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D005838:Genotype; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D011340:Problem Solving / Q000187:drug effects*; D013045:Species Specificity
D010446:Peptide Fragments; C011393:ACTH (1-10); D001535:Benactyzine; D000324:Adrenocorticotropic Hormone
Vliianie amizila i fragmenta AKTG4-10 na sposobnost' mysheĭ k ékstrapoliatsii napravleniia dvizheniia.