title: Induction of secondary immune response by reactivated Japanese encephalitis virus in latently infected mice.
abstract: Development of secondary immune response has been studied following reactivation of latent Japanese encephalitis virus (JEV) infection in mice. The virus could be reactivated in 43% of the latently infected mice at 27 weeks p.i. by treatment with cyclophosphamide. The reactivated virus induced delayed-type hypersensitivity (DTH) and leucocyte migration inhibition (LMI) responses in mice, with peak activity on Day 5 post-reactivation (p.r.). The DTH persisted at low levels for long periods. Humoral immunity measured by haemagglutination-inhibiting antibody showed a four-fold rise in antibody titres. DTH was transferable by immune spleen cells for 5 days p.r. only. It is, therefore, concluded that JEV reactivation generates a quick and short-lived secondary immune response.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002464:Cell Migration Inhibition; D004664:Encephalitis Virus, Japanese / Q000254:growth & development / Q000276:immunology; D004672:Encephalitis, Japanese / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D007116:Immunization, Passive; D007156:Immunologic Memory; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology; D014775:Virus Activation
chemical_list: D000914:Antibodies, Viral