title: Participation of various brain nuclei in the altered time course of genetic hypertension in SHR dependent on changes in calcium metabolism.
abstract: Variations in calcium alimentation influence the development of high blood pressure in genetic hypertensive rats. Different calcium feeding and changes in parathyroid hormone status cause altered cAMP-content in specific brain areas. All animals with high calcium diet show significant elevated cAMP-content in the locus coeruleus, irrespective of parathyroid status. These findings support the hypothesis that elevated cAMP-concentrations reflect an increased depressor activity of the locus coeruleus.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002136:Calcium, Dietary / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism; D008125:Locus Coeruleus / Q000378:metabolism; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D002136:Calcium, Dietary; D000242:Cyclic AMP; D002118:Calcium