title: Isolation of a retrovirus from the American bison and its relation to bovine retroviruses.
abstract: Tissue samples were removed at necropsy from five American bison (Bison bison) with clinical signs of a disease resembling malignant catarrhal fever (MCF). Using cell-associated virus techniques, attempts were made to isolate viruses from these tissues by culturing them directly or by co-culture with bovine fetal cells. Among the viruses isolated was one which was syncytiogenic and multiplied in bovine fetal spleen cells and remained highly cell-associated. The presence of reverse transcriptase activity indicated that it was a retrovirus. Also, it had antigenic cross activity with bovine syncytial virus, but not with bovine leukemia or bovine maedi-like retroviruses. We do not attribute a direct causative role of this retrovirus to MCF, but indirect relationships are possible.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D001188:Artiodactyla / Q000382:microbiology*; D012190:Retroviridae / Q000276:immunology / Q000302:isolation & purification*; D012192:Retroviridae Infections / Q000382:microbiology / Q000662:veterinary*
chemical_list: D000956:Antigens, Viral