[Cumulative effect of alcohol (ethanol) on the activity of the cerebellar Purkinje cells of the cat].
The activity of the identified cerebellar Purkinje cells after three successive intravenous injections of 2 ml/kg of 30% alcohol (ethanol) solution was studied in anaesthetized cats. After the first injection a sharp increase in the discharge frequency of Purkinje cells activated by mossy fibre afferent input was accompanied by a decrease in the discharge frequency of the Purkinje cells activated by climbing fiber input. Each successive injection of the same dose of alcohol produced a cumulative effect on the activity of the cerebellar Purkinje cells.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D002525:Cerebellar Cortex / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D011689:Purkinje Cells / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects
D000431:Ethanol
Kumuliativnoe deĭstvie alkogolia (étanola) na aktivnost' kletok Purkin'e mozzhechka koshek.