[Maxillofacial manifestations of Cowden's disease. Apropos of 2 cases].
Two new cases of Cowden's disease observed in two young sisters are reported. The diagnosis was based on the clinical observation of oral mucosa lesions (gingival hyperplasia, papillomatosis, scrotal tongue). In one case, visceral manifestations in childhood were observed. Cowden's disease is a familial affection (autosomal dominant trait) characterized by association of oral mucosa and skin lesions and of multiple hamartomas involving glandular tissues. Clinical and familial history investigations are justified by the high risk of malignant tumors (breast carcinoma).
D000293:Adolescent; D002648:Child; D005260:Female; D005885:Gingival Hyperplasia / Q000209:etiology*; D005886:Gingival Hypertrophy / Q000209:etiology*; D006223:Hamartoma Syndrome, Multiple / Q000150:complications / Q000235:genetics*; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D014063:Tongue, Fissured / Q000209:etiology*
Manifestations maxillo-faciales de la maladie de Cowden. A propos de deux observations.