Participation of various brain nuclei in the altered time course of genetic hypertension in SHR dependent on changes in calcium metabolism.
Variations in calcium alimentation influence the development of high blood pressure in genetic hypertensive rats. Different calcium feeding and changes in parathyroid hormone status cause altered cAMP-content in specific brain areas. All animals with high calcium diet show significant elevated cAMP-content in the locus coeruleus, irrespective of parathyroid status. These findings support the hypothesis that elevated cAMP-concentrations reflect an increased depressor activity of the locus coeruleus.
D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002136:Calcium, Dietary / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism; D008125:Locus Coeruleus / Q000378:metabolism; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR
D002136:Calcium, Dietary; D000242:Cyclic AMP; D002118:Calcium