5-HT2 receptor-stimulated inositol phosphate formation in rat aortic myocytes.
Serotonin (5-HT) stimulated inositol phosphate production in primary cultures of rat aortic myocytes via a 5-HT2 receptor. Agonists active at 5-HT2 receptors in other systems were also active here but the response to some agonists was potentiated by the hormone uptake blocker, cocaine HCl. Two 5-HT2 selective antagonists, ketanserin and spiperone, inhibited the serotonin-induced response while compounds selective for other 5-HT receptor subtypes did not.
D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D002712:Chlorides / Q000494:pharmacology; D007295:Inositol Phosphates / Q000096:biosynthesis*; D008094:Lithium / Q000494:pharmacology; D018021:Lithium Chloride; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D013403:Sugar Phosphates / Q000096:biosynthesis*
D002712:Chlorides; D007295:Inositol Phosphates; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013403:Sugar Phosphates; D012701:Serotonin; D008094:Lithium; D018021:Lithium Chloride