WF-10129, a novel angiotensin converting enzyme inhibitor produced by a fungus, Doratomyces putredinis.
WF-10129 is an angiotensin converting enzyme (ACE) inhibitor produced by Doratomyces putredinis. IC50 of the compound is 1.4 X 10(-8) M for the ACE activity. WF-10129 was purified from cultured filtrate by successive ion exchange chromatography and HPLC. The chemical structure 1 was elucidated on the basis of spectroscopic and chemical evidence. The compound is a dipeptide composed of L-tyrosine and a novel amino acid. WF-10129 inhibits the pressor response of angiotensin I when administered intravenously at 0.3 mg/kg in rats.
D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004151:Dipeptides / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D003904:Mitosporic Fungi / Q000254:growth & development*; D051381:Rats; D011919:Rats, Inbred Strains; D013053:Spectrophotometry
D000806:Angiotensin-Converting Enzyme Inhibitors; D004151:Dipeptides; C052542:WF 10129