title: [Modification of mucociliary clearance by a combination of theophylline with ambroxol and of ambroxol in monotherapy].
abstract: Influence on Mucociliary Clearance by a Theophylline-Ambroxol Combination and by Ambroxol in Monotherapy. In a controlled randomised double-blind study the influence of theophylline + ambroxol (TA) and ambroxol (A) on lung function and mucociliary clearance was investigated. 19 patients with chronic obstructive lung disease were treated after a 5-day wash-out period for 5 days with TA (700 mg theophylline, 60 mg ambroxol/d) or A (60 mg ambroxol/d), respectively. Measurements were done on the 5th and 10th day. Under the treatment with TA a marked improvement of lung function was observed. The mucociliary clearance improved under treatment with TA and A, with TA being significantly better compared with treatment group A.
mesh_terms: D000328:Adult; D000336:Aerosols; D000551:Ambroxol / Q000008:administration & dosage / Q000627:therapeutic use*; D001964:Bromhexine / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects*; D011897:Random Allocation; D013806:Theophylline / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000336:Aerosols; D000551:Ambroxol; D013806:Theophylline; D001964:Bromhexine
vernacular_title: Beeinflussung der mukoziliaren Clearance durch die Kombination Theophyllin mit Ambroxol sowie durch Ambroxol in einer Monotherapie.