Acute renal failure caused by polymyxin B containing ointment.
A case is presented in which a 67-year-old man suffering from non-insulin-dependent diabetes mellitus, after being treated with polymyxin B containing ointment for leg ulcers, developed acute renal failure. After a period of 13 days during which the patient was treated with peritoneal dialysis 5 times, renal function returned. At discharge creatinine-clearance was 12 ml/min. Treating large ulcers with polymyxin B may be dangerous.
D000042:Absorption; D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy; D008297:Male; D009824:Ointments; D011112:Polymyxin B / Q000008:administration & dosage / Q000009:adverse effects*; D011113:Polymyxins / Q000009:adverse effects*
D009824:Ointments; D011113:Polymyxins; D011112:Polymyxin B