title: Leukotrienes and related eicosanoids are produced by frog leukocytes.
abstract: The metabolites of inflammatory cells produced by massive infection of the peritoneal cavity of two related European species of frogs, Rana temporaria and Rana arvalis were examined for lipoxygenase-generated products of exogenous arachidonic acid. Cells of Rana temporaria produced large amounts of 5-hydroxyeicosatetraenoic acid and leukotriene B4. Cells from Rana arvalis produced only 15-hydroxyeicosatetraenoic acid. This is the first unequivocal demonstration of such enzyme activity in lower vertebrates. There was a trend towards increased mortality in the species without evidence of 5-lipoxygenase activity.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006893:Hydroxyeicosatetraenoic Acids / Q000096:biosynthesis*; D007962:Leukocytes / Q000378:metabolism*; D007975:Leukotriene B4 / Q000096:biosynthesis*; D011898:Ranidae / Q000097:blood*
chemical_list: D006893:Hydroxyeicosatetraenoic Acids; D007975:Leukotriene B4