The relationship of myeloperoxidase activity to neutrophil maturity and other hematologic indicators of infection.
Myeloperoxidase activity (MPO) in 100 male hospitalized patients was quantified by enzyme cytochemical flow cytometric analysis. These data were compared with commonly used laboratory indicators of infection. The correlation coefficients were statistically significant for increased MPO activity with band count, toxic granulation, and the Schilling Index; however, the orders of magnitude were too low to suggest the use of MPO as a clinical parameter. Patients were given an infection rank based on their numbers of abnormal laboratory indicators of infection. There was a highly significant difference in mean neutrophil peroxidase (MNP) activity between those patients with three or more indicators of infection and those with two or less: t = 3.68, p less than 0.001. It is concluded that whereas MNP may not be a useful indicator of a left shift or of leukocytosis, it might be helpful as an indicator of infection or inflammation. Further studies will be required to support this hypothesis.
D006801:Humans; D007239:Infections / Q000201:enzymology*; D007527:Isoenzymes / Q000097:blood; D008297:Male; D009504:Neutrophils / Q000201:enzymology* / Q000473:pathology; D009195:Peroxidase / Q000097:blood*; D010544:Peroxidases / Q000097:blood
D007527:Isoenzymes; D010544:Peroxidases; D009195:Peroxidase