Cardiac abnormalities in rats treated with methylphosphonothiolate.
Cardiac toxicity of methylphosphonothiolate (MPT), an organophosphorus compound, has been investigated in the rat. Subcutaneous injection of MPT (12 micrograms/kg body wt) induced cardiac arrhythmias, the occurrence of which was significantly more frequent than in the control group. Death rate among MPT-treated animals appeared to be in relationship with cardiac arrhythmias. Plasma nonesterified fatty acid concentrations increased in MPT-poisoned rats. cAMP and cGMP contents in myocardial tissue were unchanged 150 min after MPT administration, as compared with control. Similarly, no change has occurred in high energy compound levels.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004562:Electrocardiography; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006321:Heart / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D005230:Fatty Acids, Nonesterified; D009946:Organothiophosphorus Compounds; C051451:methylphosphonothiolate; D000242:Cyclic AMP; D006152:Cyclic GMP