title: S-[(N,N'-diarylamidino)methyl] diethyldithiocarbamates and related amides as potential radioprotectants.
abstract: A series of symmetrically and unsymmetrically N,N'-diaryl-substituted amidinomethyl diethyldithiocarbamates and corresponding amides have been synthesized and tested for potential radioprotective activity. Antiradiation data for 10 amidines are presented. Half of the amidines showed low toxicity and radioprotective activity, based on both protective index (PI) and 30-day survival (greater than 35%) after lethal irradiation (800-rad X-rays). All (N-arylcarbamoyl)methyl diethyldithiocarbamates investigated were nonprotective.
mesh_terms: D000578:Amidines / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D004050:Ditiocarb / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship; D014916:Whole-Body Irradiation
chemical_list: D000578:Amidines; D011837:Radiation-Protective Agents; D004050:Ditiocarb