Beta-adrenergic receptors and oxygen transport.
We investigated whether stimulation of baboon erythrocyte beta-adrenoreceptors affects oxygen transport by haemoglobin. To assess oxygen transport we measured the PO2 at which the haemoglobin was 50% saturated (P50) and the Hill parameter 'n'. Blood at PO2s ranging from 10 to 90 mm Hg was exposed to a 10(-3) M concentration of the agonists l-isoproterenol, l-epinephrine and l-norepinephrine in the presence and absence of 10(-5) M dl-propranolol. None of the adrenergic agents which were used in these experiments produced significant changes in either 'n' or P50 and the concentrations of 2,3-diphosphoglycerate and lactate were not altered by the agonists. We conclude from these results that short-term adrenergic stimulation of the baboon erythrocyte beta-adrenoreceptor does not affect factors known to influence oxygen transport, oxygen delivery or haemoglobin itself.
D019794:2,3-Diphosphoglycerate; D000818:Animals; D004163:Diphosphoglyceric Acids / Q000097:blood; D004837:Epinephrine / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010101:Oxygen Consumption; D010108:Oxyhemoglobins / Q000378:metabolism; D010215:Papio; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D007773:Lactates; D010108:Oxyhemoglobins; D011943:Receptors, Adrenergic, beta; D019794:2,3-Diphosphoglycerate; D019344:Lactic Acid; D011433:Propranolol; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine