Adenovirus infection reverses the antiviral state induced by human interferon.
HeLa cells treated with human lymphoblastoid interferon do not synthesize poliovirus proteins. The antiviral state against poliovirus is reversed if cells are previously infected with adenovirus type 5. A late gene product seems to be involved in this reversion, since no effect is observed at early stages of infection or in the presence of aphidicolin.
D000227:Adenine Nucleotides / Q000378:metabolism; D000256:Adenoviridae / Q000235:genetics / Q000276:immunology*; D006367:HeLa Cells / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D009843:Oligoribonucleotides / Q000378:metabolism; D017955:Poliovirus / Q000276:immunology / Q000378:metabolism; D018139:Simplexvirus / Q000276:immunology; D014762:Viral Interference; D014764:Viral Proteins / Q000096:biosynthesis
D000227:Adenine Nucleotides; D007370:Interferon Type I; D009843:Oligoribonucleotides; D014764:Viral Proteins; C023505:2',5'-oligoadenylate