title: Possible role of cAMP in the differentiation of Trypanosoma cruzi.
abstract: To assess the possible action of cAMP on the cell differentiation of Trypanosoma cruzi, we determined both cAMP levels and cAMP-binding activities of epimastigotes and trypomastigotes of this parasite. Trypomastigotes showed a 4-fold higher cAMP content and a 2.5-fold increase in the specific activity of a cAMP-binding protein with identical properties to that of epimastigotes. The high levels of cAMP present in trypomastigotes strongly suggest a role of this cyclic nucleotide on the differentiation of T. cruzi.
mesh_terms: D000818:Animals; D002499:Centrifugation, Density Gradient; D002848:Chromatography, DEAE-Cellulose; D000242:Cyclic AMP / Q000032:analysis / Q000378:metabolism*; D014349:Trypanosoma cruzi / Q000166:cytology / Q000378:metabolism*
chemical_list: D000242:Cyclic AMP