Human herpesvirus-6 (HHV-6, HBLV) in sarcoidosis and lymphoproliferative disorders.
Serologic studies were done to estimate the antibody prevalence against human herpesvirus 6 (HHV-6) in patients with malignant lymphomas, Sjögren's syndrome and sarcoidosis. Serologic studies showed IgG antibody titers against HHV-6 in up to 41% of patients with sarcoidosis, 50-70% with malignant lymphomas and in 36% with Sjögren's syndrome. In situ hybridization on lymph node biopsies was positive for HHV-6 genome in 1 out of 5 sarcoidosis lymph nodes.
D000914:Antibodies, Viral / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006564:Herpesviridae / Q000276:immunology* / Q000648:ultrastructure; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007150:Immunohistochemistry; D008223:Lymphoma / Q000276:immunology* / Q000382:microbiology; D008854:Microscopy, Electron; D009693:Nucleic Acid Hybridization; D012507:Sarcoidosis / Q000276:immunology* / Q000382:microbiology; D012859:Sjogren's Syndrome / Q000276:immunology* / Q000382:microbiology
D000914:Antibodies, Viral; D007074:Immunoglobulin G