Abelson virus abrogation of interleukin-3 dependence in a lymphoid cell line.
Among several tyrosine-protein kinases, only v-abl could abrogate interleukin 3 dependence of a lymphoblastoid cell line; v-src and v-fps proteins gave partial or no interleukin 3 independence, respectively. Lymphokine independence was achieved via a nonautocrine mechanism. Direct involvement of c-myc in this process was not evident.
D000011:Abelson murine leukemia virus / Q000235:genetics*; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology; D001853:Bone Marrow; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D005814:Genes, Viral; D007377:Interleukin-3 / Q000494:pharmacology*; D009052:Leukemia Virus, Murine / Q000235:genetics*; D051379:Mice; D008979:Moloney murine leukemia virus / Q000235:genetics*; D009857:Oncogenes; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*
D007377:Interleukin-3; D011505:Protein-Tyrosine Kinases