Kaluresis independent K-homeostasis: glucagon and B receptor blockade in pancreatectomized dogs.
Seventy minutes post pancreatectomy, in dogs that are K loaded - made abruptly hyperkalemic and "life threatened" - by infusion with 2 mEgKC1/kg-/hr until prelethal ECG changes of hyperkalemic cardiotoxicity appear, a kaluresis independent K homeostatic mechanism transfers about 2/3 of administered K to intracellular fluid. Treatment of K loaded pancreatectomized dogs with glucagon or a B receptor blockading dosage of propranolol does not alter the proportion transferred, but treatment with glucagon and propranolol reduces it. It appears that in pancx dogs there is a reciprocal relation between insulin and B receptor mediated K transfer and that glucagon is involved in activity of the kaluresis independent K homeostatic mechanism.
D000818:Animals; D004285:Dogs; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D006706:Homeostasis; D006947:Hyperkalemia / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008297:Male; D010180:Pancreatectomy; D011188:Potassium / Q000097:blood / Q000652:urine*; D011433:Propranolol / Q000494:pharmacology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000378:metabolism
D007328:Insulin; D011943:Receptors, Adrenergic, beta; D005934:Glucagon; D011433:Propranolol; D011188:Potassium