title: [Functional properties of E. coli SSB-proteins in vivo].
abstract: An essential function of single-stranded DNA-binding (SSB) proteins--a defense from nuclease action, determined by their first and second domains, is realized in conditions of normal cell metabolism. With the inhibition of the replicative furcula growth and total protein synthesis (imbalance state), the SSB protein function associated with the third domain and responsible for certain modifications in DNA polymerase II activity is realized. This causes DNA degeneration and increases radiosensitivity of cells.
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism* / Q000528:radiation effects; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism* / Q000528:radiation effects; D004257:DNA Polymerase II / Q000378:metabolism; D004261:DNA Replication / Q000528:radiation effects; D004264:DNA Topoisomerases, Type I / Q000378:metabolism* / Q000528:radiation effects; D004269:DNA, Bacterial / Q000378:metabolism*; D004277:DNA, Single-Stranded / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism* / Q000528:radiation effects; D009154:Mutation; D011836:Radiation Tolerance; D013696:Temperature; D014466:Ultraviolet Rays
chemical_list: D001426:Bacterial Proteins; D002868:Chromosomal Proteins, Non-Histone; D004269:DNA, Bacterial; D004277:DNA, Single-Stranded; D004257:DNA Polymerase II; D004264:DNA Topoisomerases, Type I
vernacular_title: Funktsional'nye svoĭstva SSB-belkov E. coli in vivo.