Oncogenous osteomalacia: a new case secondary to a malignant tumor.
A case of oncogenous osteomalacia secondary to a fibrous malignant histiocytoma in a 31-year-old male is described. The patient also demonstrated a lupuslike anticoagulant. Clinical signs of osteomalacia preceded by 9 years those of the tumor, a feature occurring in only 8% of these malignancies. Surgical resection of the tumor and surrounding tissues was followed by a clinical improvement and a return to normal of serum phosphorus and tubular reabsorption of phosphate, though the lupuslike anticoagulant persisted. This first description of a fibrous malignant histiocytoma with associated osteomalacia and lupuslike anticoagulant makes compulsory the inclusion of these syndromes among those already described that may appear with this tumor.
D000328:Adult; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors / Q000097:blood; D018219:Histiocytoma, Benign Fibrous / Q000097:blood / Q000150:complications* / Q000473:pathology; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D008297:Male; D010018:Osteomalacia / Q000097:blood / Q000209:etiology*; D010710:Phosphates / Q000097:blood; D012983:Soft Tissue Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology
D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor; D010710:Phosphates