title: Combination treatment with ranitidine and sodium bicarbonate prior to obstetric anaesthesia.
abstract: The gastric pH and volume were measured in 175 patients undergoing elective, and 313 undergoing emergency, obstetric procedures. Ranitidine 150 mg was administered orally every 6 hours in labour and at least 2 hours before elective Caesarean section. Patients received 20 ml of 8.4% sodium bicarbonate orally immediately prior to induction of anaesthesia. The combination of ranitidine and sodium bicarbonate produced marked alkalinisation of gastric contents (mean pH 8.9). The administration of sodium bicarbonate pre-operatively in patients who received ranitidine less than 2 hours before operation led to satisfactory elevation of gastric pH. Only four patients had a gastric pH less than 2.5, one patient refused any medication, two received only ranitidine and one patient had a long interval from administration of bicarbonate to aspiration of gastric contents. Gastric volumes were high in labouring patients (mean 84 ml) despite administration of ranitidine. The effectiveness of sodium bicarbonate as a single dose antacid therapy prior to obstetric anaesthesia requires further study.
mesh_terms: D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical; D001639:Bicarbonates / Q000008:administration & dosage / Q000627:therapeutic use*; D002585:Cesarean Section; D004359:Drug Therapy, Combination; D005260:Female; D005745:Gastric Acidity Determination; D005766:Gastrointestinal Contents; D006801:Humans; D011247:Pregnancy; D011292:Premedication; D011899:Ranitidine / Q000008:administration & dosage / Q000627:therapeutic use*; D012964:Sodium / Q000008:administration & dosage / Q000627:therapeutic use*; D017693:Sodium Bicarbonate; D013997:Time Factors
chemical_list: D001639:Bicarbonates; D011899:Ranitidine; D017693:Sodium Bicarbonate; D012964:Sodium