[Regression analysis in the study of dynamics of 5-nucleotidase activity in mouse peritoneal exudate macrophages].
The time course of the activity of 5-nucleotidase of peritoneal exudate macrophages (PEM) was studied on mice. Regression models of in time changes in the activity of PEM 5-nucleotidase after intraperitoneal administration of 2 immunostimulators: salmosan and blastolysine were constructed by the results of the study. Within the experimentally chosen periods of the study the time changes in the enzyme activity after administration of either salmosan or blastolysine could be adequately approximated by linear regression. The models enabled predicting the enzyme activity levels at various moments within wide ranges after administration of the immunostimulators. Moreover, it is recommended that the regression models of changes in 5-nucleotidase activity after intraperitoneal administration of the immunostimulators be used for quantitative comparison of their efficacy.
D015720:5'-Nucleotidase; D000276:Adjuvants, Immunologic; D000818:Animals; D000900:Anti-Bacterial Agents; D004789:Enzyme Activation; D005122:Exudates and Transudates / Q000201:enzymology; D006020:Glycopeptides / Q000494:pharmacology; D008264:Macrophages / Q000201:enzymology*; D051379:Mice; D009708:Nucleotidases / Q000378:metabolism*; D010529:Peritoneal Cavity / Q000166:cytology; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D012044:Regression Analysis; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D011135:Polysaccharides, Bacterial; C025182:blastolysin; C029023:salmozan; D009708:Nucleotidases; D015720:5'-Nucleotidase
Primenenie metodov regressionnogo analiza pri izuchenii dinamiki aktivnosti 5-nukleotidazy makrofagov peritoneal'nogo ékssudata mysheĭ.