title: Observations on the replication of ectromelia virus in mouse-derived cell lines: implications for epidemiology of mousepox.
abstract: Ectromelia virus was shown to replicate in vitro in all lymphoma cell lines and in a small proportion of hybridoma lines tested. It was demonstrated that certain hybridoma cell lines, which were passed in ectromelia virus-infected mice, yielded ectromelia virus infectivity on explantation into tissue culture. This finding further substantiated the belief that ascitic fluid and hybridoma cell lines exposed to virus during mouse-passage could be important in the epidemiology of mousepox.
mesh_terms: D000818:Animals; D002460:Cell Line; D004481:Ectromelia virus / Q000502:physiology*; D004482:Ectromelia, Infectious / Q000453:epidemiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011213:Poxviridae Infections / Q000453:epidemiology*; D014779:Virus Replication