Genomic variation of adenovirus type 5 isolates recovered from bone marrow transplant recipients.
We characterized the genomic variation of adenovirus type 5 isolates recovered from bone marrow transplant recipients in Seattle between 1976 and 1982. By restriction endonuclease analysis, we identified three new adenovirus genomic variants, each associated with a single invasive adenovirus infection. In addition, we were able to obtain suggestive evidence for a nosocomial spread of a particular group of isolates within this population. This study demonstrates that the technique of restriction endonuclease analysis is an important epidemiological tool for investigating viral infections.
D000257:Adenoviridae Infections / Q000382:microbiology*; D000258:Adenovirus Infections, Human / Q000382:microbiology*; D000260:Adenoviruses, Human / Q000235:genetics* / Q000302:isolation & purification; D016026:Bone Marrow Transplantation; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000032:analysis; D005814:Genes, Viral; D014644:Genetic Variation; D006801:Humans; D007108:Immune Tolerance
D004279:DNA, Viral; D004262:DNA Restriction Enzymes