[Role of erythrocyte membrane cholesterol in disorders of their structuro-functional status in patients with ischemic heart disease].
Increased molar cholesterol/phospholipid ratios, significantly increased membrane microviscosity, reduced filterability through a 3 micron-pore filter, increased aggregation and longer disaggregation time, and occasional abnormally large cells were found in erythrocyte assays of 80 coronary patients, as compared to normal subjects. It is suggested that erythrocyte microrheologic disorders are related to excessive cellular cholesterol content in coronary patients.
D000328:Adult; D002784:Cholesterol / Q000097:blood*; D003327:Coronary Disease / Q000097:blood*; D004578:Electron Spin Resonance Spectroscopy; D004907:Erythrocyte Deformability; D004910:Erythrocyte Membrane / Q000502:physiology; D004912:Erythrocytes / Q000032:analysis* / Q000473:pathology; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008563:Membrane Lipids / Q000032:analysis*; D008875:Middle Aged; D014783:Viscosity
D008055:Lipids; D008563:Membrane Lipids; D002784:Cholesterol
Rol' kholesterina membran éritrotsitov v narusheniĭ ikh strukturno-funktsional'nogo sostoianiia u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.