Effect of prolonged angiotensin converting enzyme inhibition on ambulatory blood pressure of normotensive volunteers.
The blood pressure effect of 8-day angiotensin converting enzyme (ACE) inhibition was studied in normotensive healthy volunteers maintained on an unrestricted salt intake. Six volunteers received cilazapril (5 mg/day), 5 perindopril (8 mg/day) and 5 CGS14824A (10 mg/day). The 3 investigational inhibitors were found to have no consistent effect on blood pressure monitored during day-time outside the clinic using a semi-automatic blood pressure recorder (Remler M2000).
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors; D001552:Benzazepines / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D017315:Cilazapril; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D020913:Perindopril; D011724:Pyridazines / Q000494:pharmacology
D000806:Angiotensin-Converting Enzyme Inhibitors; D001552:Benzazepines; D007211:Indoles; D011724:Pyridazines; D017315:Cilazapril; C044946:benazepril; D020913:Perindopril