The genetic toxicology of some hydrocarbon and oxygenated solvents.
Two hydrocarbon solvents (heptane and Special Boiling Point Spirit 100/140) and eight oxygenated solvents [methyl ethyl ketone, methyl isobutyl ketone, diacetone alcohol, di-isobutyl ketone, isopropyl ether, hexylene glycol, secondary butyl alcohol and ME 6K (pentoxone)] have been tested for genotoxic activity. The solvents were tested in bacterial mutation assays, a yeast assay for mitotic gene conversion and in cultured mammalian cells (either rat liver or Chinese hamster ovary) for structural chromosome damage. All of the solvents gave a negative response in the bacterial mutation assays and the yeast mitotic gene conversion assay. In the rat liver chromosome assay, diacetone alcohol evoked a weak positive response, the remaining solvents gave a negative response.
D000438:Alcohols / Q000633:toxicity; D000473:Alkanes / Q000633:toxicity; D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D006224:Cricetinae; D004987:Ethers / Q000633:toxicity; D006838:Hydrocarbons / Q000633:toxicity*; D007659:Ketones / Q000633:toxicity; D009152:Mutagenicity Tests / Q000379:methods*; D051381:Rats; D012997:Solvents / Q000633:toxicity*
D000438:Alcohols; D000473:Alkanes; D004987:Ethers; D006838:Hydrocarbons; D007659:Ketones; D012997:Solvents