The proteinases in shock.
The nomenclature of proteinases and their role in shock are reviewed. The regulation of the kallikrein-kinin system, coagulation and fibrinolysis is described with special emphasis on the role of granulocytes for the proteolysis in shock particularly in the lung. The effect of proteinase inhibitors on such systems is described, together with proteinase inhibitors effects on granulocytes and their possible role in the prevention especially of lung damage after shock.
D001777:Blood Coagulation; D010450:Endopeptidases / Q000378:metabolism*; D005342:Fibrinolysis; D016670:Gabexate; D006098:Granulocytes / Q000378:metabolism; D006146:Guanidines / Q000627:therapeutic use; D006801:Humans; D007610:Kallikreins / Q000378:metabolism; D007705:Kinins / Q000378:metabolism; D008168:Lung / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology; D011480:Protease Inhibitors / Q000627:therapeutic use*; D012769:Shock / Q000188:drug therapy / Q000201:enzymology* / Q000503:physiopathology
D006146:Guanidines; D007705:Kinins; D011480:Protease Inhibitors; D016670:Gabexate; D010450:Endopeptidases; D007610:Kallikreins