The effects of glycosaminoglycans, pyrophosphate and allopurinol treatment on urease-induced crystallization in vitro.
Previous studies have found that human urine inhibits urease-induced crystallization in synthetic urine. To identify the inhibitory components the effects of chondroitin sulphate, heparin and pyrophosphate on urease-induced crystallization were studied and the inhibitory capacity of human urine collected during and before/after allopurinol treatment compared. None of the substances studied nor allopurinol treatment was found to influence the urease-induced crystallization. These findings do not support the idea that glycosaminoglycans or pyrophosphate are responsible for the inhibitory effect detected in human urine.
D000493:Allopurinol / Q000494:pharmacology*; D003460:Crystallization; D011756:Diphosphates / Q000494:pharmacology*; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D014510:Urease / Q000494:pharmacology*; D014556:Urine
D011756:Diphosphates; D006025:Glycosaminoglycans; D000493:Allopurinol; D014510:Urease