The effect of the imidazodiazepine Ro 15-4513 on the anticonvulsant effects of diazepam, sodium pentobarbital and ethanol.
The ability of the imidazodiazepine Ro 15-4513 to antagonize the anticonvulsant effects of diazepam, sodium pentobarbital and ethanol was investigated. Ro 15-4513 alone significantly lowered seizure threshold to bicuculline and this effect subtracted from the anticonvulsant effects of sodium pentobarbital and ethanol. In contrast, Ro 15-4513 completely reversed the anticonvulsant effects of diazepam, consistent with suggestions that it is a competitive ligand for benzodiazepine receptors.
D000818:Animals; D001386:Azides / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D003292:Convulsants; D003975:Diazepam / Q000037:antagonists & inhibitors*; D000431:Ethanol / Q000037:antagonists & inhibitors*; D008024:Ligands; D008297:Male; D051379:Mice; D010424:Pentobarbital / Q000037:antagonists & inhibitors*; D011963:Receptors, GABA-A / Q000378:metabolism
D001386:Azides; D003292:Convulsants; D008024:Ligands; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D000431:Ethanol; C042957:Ro 15-4513; D010424:Pentobarbital; D003975:Diazepam