Giant cell pneumonia caused by parainfluenza type 3 in a patient with acute myelomonocytic leukemia.
A 4 1/2-year-old boy with acute myelomonocytic leukemia developed fever, neutropenia, and a prolonged respiratory illness while receiving maintenance chemotherapy. An open lung biopsy specimen demonstrated a giant cell pneumonia with intracytoplasmic and probable intranuclear viral inclusions of the paramyxovirus type. Serologic studies demonstrated convincing evidence of a parainfluenza type 3 infection. Although parainfluenza type 3-induced giant cell pneumonia has been reported in infants with the severe combined immunodeficiency syndrome, to our knowledge, this is the first reported case of this complication in a patient with leukemia.
D002675:Child, Preschool; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008168:Lung / Q000473:pathology; D008297:Male; D010224:Parainfluenza Virus 3, Human; D018184:Paramyxoviridae Infections / Q000150:complications*; D011658:Pulmonary Fibrosis / Q000209:etiology* / Q000473:pathology