title: Contact dermatitis in blacks.
abstract: Black skin is characterized by structural and functional differences such as increased stratum corneum cohesion, melanin content, and stratum corneum layers. These differences seem to make black skin difficult for irritants and light to penetrate, thus explaining the common opinion that skin in blacks is harder and develops contact dermatitis less frequently. The paucity of interpretable epidemiologic data and of clinical and experimental studies does not permit confirmation of this hypothesis, and the few data available are controversial. This article describes the main physiologic differences between black and white barrier function and reviews the literature on irritation, sensitization, and transcutaneous penetration. We found that the data are still too incomplete to generalize on the resistance, or lack thereof, of black skin (versus white skin) to chemical irritation, sensitization, and penetration.
mesh_terms: D044383:Black People; D003877:Dermatitis, Contact / Q000453:epidemiology / Q000208:ethnology* / Q000503:physiopathology; D006801:Humans; D007509:Irritants / Q000009:adverse effects; D012867:Skin / Q000033:anatomy & histology; D012869:Skin Absorption / Q000187:drug effects; D012879:Skin Physiological Phenomena; D012880:Skin Pigmentation / Q000187:drug effects
chemical_list: D007509:Irritants