Hepatitis B related childhood hepatocellular carcinoma. Childhood hepatic malignancies.
The case of hepatocellular carcinoma (HCC) with foci of hepatoblastoma in a 7-year-old boy, the son of a hepatitis B surface antigen (HBsAg) carrier mother, is described. Twelve other malignant liver tumors in children were tumors in children were also reviewed for HBsAg and hepatitis B core antigen (HBcAg). Both were negative in all (nine) hepatoblastomas. One of three HCC demonstrated positivity for HBsAg. These cases illustrate the importance of hepatitis B virus infection in early childhood and stress the need for careful screening in pregnant women, irrespective of ethnic backgrounds.
D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006513:Hepatitis B e Antigens / Q000032:analysis; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens