title: [Adrenal glucocorticoid function and its regulation in human prenatal ontogeny and in the 1st week of life].
abstract: A comparison of cortisol and ACTH level determination in 82 human fetal sera obtained in the 11th-34th week of the intrauterine development and 50 sera from infants 1-7 days of age has revealed several stages of pituitary-adrenal system (PAS) maturation. PAS is immature in the first trimester of embryogenesis when cortisol concentration in the human fetal blood is low. The functional relations between pituitary and adrenal glands begin to establish in the middle of prenatal developmental period. A prominent response to delivery stress indicates that by delivery PAS reaches a certain stage of maturation. The feedback between ACTH and cortisol secretions in the blood of infants 1-7 days of age demonstrates that the refractory period of PAS is absent in the neonates during the first week of their life.
mesh_terms: D000311:Adrenal Glands / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D005865:Gestational Age; D005938:Glucocorticoids / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007231:Infant, Newborn; D011863:Radioimmunoassay
chemical_list: D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
vernacular_title: Gliukokortikoidnaia funktsiia nadpochechnikov i ee reguliatsiia u cheloveka v prenatal'nom ontogeneze i v period 1-ĭ nedeli zhizni.