Increased renin release by exogenous prostaglandin E1 in liver cirrhosis with and without ascites.
To evaluate the sensitivity of the renin-angiotensin-aldosterone system in patients with liver cirrhosis, prostaglandin E1 was intravenously administered at the rate of 50 micrograms/hour for two hours to the 11 control subjects and 11 patients with liver cirrhosis (6 compensated and 5 decompensated). Basal plasma renin activity (PRA) in decompensated patients was significantly higher than those in control and compensated cirrhotics (P less than 0.01). Basal plasma aldosterone was also higher in decompensated than in control and compensated patients, but without significance. PGE1 had no virtual effect on PRA in control, but stimulated PRA in liver cirrhotics, in which statistical significance was only observed in decompensated (basal vs. one hour after PGE1: 2.4 +/- 0.9 ng/ml/min (mean +/- SE) vs. 6.9 +/- 2.1: P less than 0.025). The rate of renin release was significantly higher in compensated than in decompensated (327 +/- 50% vs. 143 +/- 26: P less than 0.05). Though PGE1 also increased plasma aldosterone in liver cirrhotics, statistical change was not seen. Fractional excretion of urinary sodium after PGE1 increased significantly in control (P less than 0.025), but not in liver cirrhotics. These results indicate that the renin-angiotensin-aldosterone system is easily activated by PGE1 in patients with liver cirrhosis and further suggest that the sensitivity of this system in compensated is more augmented than in decompensated patients.
D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood; D000527:Alprostadil / Q000494:pharmacology*; D001201:Ascites / Q000378:metabolism*; D006801:Humans; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood*
D000450:Aldosterone; D012083:Renin; D000527:Alprostadil