title: [Creation of an avirulent and immunogenic mutant from the rhinopneumonitis virus].
abstract: An avirulent immunogenic virus strain mutant of the causative agent of rhinopneumonia was found to cause abortions and respiratory diseases in horses. The mutant was obtained with the use of a virulent strain that induced strongly manifested clinical symptoms of the disease, and was cultured in cell media containing 5-iodine-2-desoxiuridine as an antimetabolite, following a definite pattern. It was found that the mutant completely lost its virulence, however, it retained its immunogenicity. It likewise retained these newly acquired biologic properties with regard to its being stable and irreversible. Animals vaccinated with this mutant did not act as carriers, neither did they shed any virus. The mutant is now used in the production of a vaccine for the practice.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D005260:Female; D006168:Guinea Pigs; D006564:Herpesviridae / Q000472:pathogenicity*; D004861:Herpesvirus 1, Equid / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D006736:Horses; D007065:Idoxuridine / Q000494:pharmacology; D007114:Immunization; D008297:Male; D009154:Mutation; D011247:Pregnancy; D014765:Viral Vaccines / Q000276:immunology / Q000302:isolation & purification; D014774:Virulence / Q000187:drug effects; D014776:Virus Cultivation
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines; D007065:Idoxuridine
vernacular_title: Sŭzdavane na avirulenten i imunogenen mutant ot virusa na rinopnevmonita.