[Naloxone-reversible analgesia as a result of stimulation of the habenula in the rat].
Electrical stimulation of rat habenular complex induces analgesia, evaluated by the tail-flick test, dependent on intensity of stimulation with a long post-effect, that is reversible by naloxone and without behavior effects at less that 400 mA. Bilateral destruction of habenula fails to provoke hyperesthesia but causes more marked long-term tolerance effects than in controls. Anatomy suggests that the habenula activates an inhibitory descending system in the spinal cord with a probable relay in the dorsal raphe and involving an endogenous opioid-dependent stage.
D000818:Animals; D004027:Diencephalon / Q000187:drug effects / Q000503:physiopathology*; D004525:Efferent Pathways / Q000503:physiopathology; D004558:Electric Stimulation; D005260:Female; D009270:Naloxone / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology*; D011903:Raphe Nuclei / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology*; D013116:Spinal Cord / Q000503:physiopathology
D011957:Receptors, Opioid; D009270:Naloxone
Analgésie naloxone réversible par stimulation de l'habénula chez le rat.