Ketoconazole-induced changes in selected canine hormone concentrations.
The effects of administering ketoconazole at a high dosage (30 mg/kg of body weight/day) and at a low dosage (10 mg/kg/day) on steroidogenesis in the dog were compared. Ketoconazole significantly suppressed basal plasma cortisol concentrations (P = 0.001), cortisol responsiveness to ACTH (P = 0.002 to 0.005), and serum testosterone concentrations (P = 0.0005). The data indicated a rebound effect after ketoconazole treatment was stopped and that testosterone suppression was being overridden at lower ketoconazole doses. Plasma 17-alpha-hydroxyprogesterone concentrations (P = 0.0005) and serum progesterone concentrations (P = 0.014 to 0.003) were significantly increased during ketoconazole treatment. Aldosterone, 11-desoxycortisol, and 17-beta-estradiol concentrations did not change significantly during ketoconazole treatment.
D019326:17-alpha-Hydroxyprogesterone; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000097:blood; D000818:Animals; D003350:Cortodoxone / Q000097:blood; D004285:Dogs / Q000097:blood*; D004958:Estradiol / Q000097:blood; D006854:Hydrocortisone / Q000097:blood* / Q000378:metabolism; D006908:Hydroxyprogesterones / Q000097:blood; D007654:Ketoconazole / Q000494:pharmacology*; D008297:Male; D011374:Progesterone / Q000097:blood*; D013739:Testosterone / Q000097:blood*
D006908:Hydroxyprogesterones; D013739:Testosterone; D000450:Aldosterone; D011374:Progesterone; D004958:Estradiol; D019326:17-alpha-Hydroxyprogesterone; D000324:Adrenocorticotropic Hormone; D007654:Ketoconazole; D003350:Cortodoxone; D006854:Hydrocortisone