title: Human papillomavirus associated with vaginal intraepithelial neoplasia in women exposed to diethylstilbestrol in utero.
abstract: Five out of 959 young women, exposed to diethylstilbestrol (DES) in utero, developed vaginal intraepithelial neoplasia while they were under follow-up in the Diethylstilbestrol-Adenosis Project at Baylor College of Medicine, Houston, Texas. We suggest that the development of the vaginal intraepithelial neoplasia at a younger age than usual may be caused by a higher susceptibility of the DES-exposed patient to factors associated with the development of intraepithelial neoplasia. A common finding in all five women was the detection of the deoxyribonucleic acid (DNA) of human papillomavirus types 6 or 16 in their lesions, using high-stringency in situ hybridization. The role of human papillomavirus and herpes simplex virus in the etiology of intraepithelial neoplasia is discussed. Close follow-up is recommended for DES-exposed patients, especially those who have risk factors known to be associated with genital neoplasia.
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D004279:DNA, Viral / Q000302:isolation & purification; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D006561:Herpes Simplex / Q000150:complications; D006801:Humans; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000235:genetics; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012306:Risk; D014412:Tumor Virus Infections / Q000150:complications*; D014625:Vaginal Neoplasms / Q000139:chemically induced* / Q000209:etiology
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D004054:Diethylstilbestrol