Two rat homologues of human cystatin C.
Two immunochemically related forms of cystatin C-like inhibitors which differ in their Mr app and isoelectric point have been found both in urine and seminal vesicles of rats. Amino-terminal sequences of these two cystatins are identical within the same fluid and exhibit a high degree of homology with that of human cystatin C. However, cystatins C purified from urine lack eight residues at their amino-terminal end when compared to those of seminal vesicles. The occurrence of two cystatin C-like components in rat fluids has been found to be due to the presence of a glycosylated form reported here as cystatin Cg which specifically binds concanavalin A and is susceptible to endo-beta-N-acetylglucosaminidase treatment.
D000595:Amino Acid Sequence; D000818:Animals; D055316:Cystatin C; D015891:Cystatins; D006023:Glycoproteins / Q000302:isolation & purification*; D007158:Immunologic Techniques; D008969:Molecular Sequence Data; D011506:Proteins / Q000302:isolation & purification; D011507:Proteinuria; D051381:Rats; D012661:Semen / Q000032:analysis; D012689:Sequence Homology, Nucleic Acid
C525030:CST3 protein, human; C525032:Cst3 protein, rat; D055316:Cystatin C; D015891:Cystatins; D006023:Glycoproteins; D011506:Proteins