The early enhancer-promoter of BKV and host range for transformation.
The early genes of the human papovavirus BKV and simian virus 40 (SV40) show a different host range for transformation. The early region of SV40 efficiently transforms human fibroblast cells, whereas the early region of BKV does not. Interchanging noncoding enhancer-promoter sequences around the origin of replication between BKV and SV40 showed that the early enhancer-promoter sequences of BKV and SV40 could substitute for each other, as far as the induction of expression of tumor antigens and morphological transformation is concerned; the efficiency of transformation was influenced by the enhancer-promoter sequences, and the difference in host range for transformation between BKV and SV40 was determined by the early gene products rather than by the enhancer-promoter sequences.
D000818:Animals; D000957:Antigens, Viral, Tumor / Q000235:genetics; D001739:BK Virus / Q000235:genetics* / Q000276:immunology / Q000502:physiology; D002472:Cell Transformation, Viral; D004742:Enhancer Elements, Genetic; D005347:Fibroblasts; D005809:Genes, Regulator; D005814:Genes, Viral; D006801:Humans; D007668:Kidney; D008297:Male; D010957:Plasmids; D011120:Polyomavirus / Q000235:genetics*; D011401:Promoter Regions, Genetic; D051381:Rats; D013539:Simian virus 40 / Q000235:genetics; D012867:Skin
D000957:Antigens, Viral, Tumor