Production of the angiotensin converting enzyme (ACE) in cultures of rat peritoneal macrophages.
Some authors attributed an increase in ACE activity in sarcoidosis to high production of this enzyme by alveolar macrophages. In order to study the production of ACE by peritoneal rat macrophages, we measured the ACE activity, by a modified version of Friedland and Silverstein's technique, in cultures of rat peritoneal macrophages, with dexamethasone, with Complete Freund Adjuvent (C.F.A.) or sarcoidosis node extract (Kveim Antigen). ACE activity was not detected in cultures. Our results were discussed.
D000818:Animals; D002452:Cell Count; D002470:Cell Survival; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis*; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains; D012507:Sarcoidosis / Q000201:enzymology*
D003907:Dexamethasone; D007703:Peptidyl-Dipeptidase A