title: Recovery and probable persistence of cytomegalovirus in human inner ear fluid without cochlear damage.
abstract: Cytomegalovirus (CMV) was recovered from a 5-month-old infant with probable congenital infection. In life, no hearing impairment had been observed. Auditory brain stem evoked responses were bilaterally intact. At necropsy, both temporal bones were morphologically normal, as demonstrated by light and electron microscopy. Sensory hair cells of the organ of Corti appeared intact. Cytomegalovirus was recovered from a mixture of perilymph and endolymph, but not the brain, CSF, or vitreous humor. This appears to be the first report of an individual with an inner ear CMV infection in which neither structural nor functional alterations of the inner ear were apparent. This case also suggests that CMV can persist within the inner ear for prolonged periods following congenital infection.
mesh_terms: D001284:Atrophy; D001921:Brain / Q000473:pathology; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000151:congenital*; D004660:Encephalitis / Q000209:etiology; D005260:Female; D006320:Hearing Tests; D006801:Humans; D007223:Infant; D007761:Labyrinthine Fluids / Q000382:microbiology*; D008831:Microcephaly / Q000209:etiology; D013701:Temporal Bone / Q000473:pathology; D013997:Time Factors