Use of gallium, colloids and pertechnetate as carriers of drugs for selective action.
A pharmacodynamic hypothesis is formulated which considers using substances such as gallium, with predilection to locate in neoplasm and inflammation, to increase the therapeutic effect in the disease-affected area. Drugs carried by a colloid can be directed to the liver, IDA derivatives which are metabolized by hepatocytes can also be used as transporters of drugs to the liver and to the hepatobiliary tree because they are eliminated through that route. In diseases which affect the blood-brain barrier substance such as pertechnetate can be used as drug carriers. Pertechnetate and other substances which are eliminated through the kidneys may be used as carriers for drugs in certain renal diseases. This therapeutic approach can be used if the amount of carrier is not toxic to the target organ, if the time of action is sufficient and if the bond between drug and carrier is strong.
D001921:Brain / Q000378:metabolism; D003102:Colloids / Q000008:administration & dosage*; D005708:Gallium / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D014677:Pharmaceutical Vehicles; D013670:Sodium Pertechnetate Tc 99m / Q000008:administration & dosage* / Q000378:metabolism
D003102:Colloids; D014677:Pharmaceutical Vehicles; D013670:Sodium Pertechnetate Tc 99m; D005708:Gallium