Cholestatic features in hepatitis A.
The clinical, biochemical and histological characteristics of 13 cases of acute hepatitis A were evaluated. In 10 biopsies moderate to severe cholestasis was seen consisting of bile thrombi, cholestatic liver cell rosettes and ductular transformation of hepatocytes as shown on keratin- and S-100 immunostaining. The periportal spotty necrosis may play a role in the pathogenesis of cholestasis in hepatitis A by creating an interruption in continuity of bile flow. In 6 cases, abnormal ductular epithelium was seen resembling the ductular lesion in septicemia. Such ductular lesion may be related to the accumulation of leucotrienes as a result of cholestasis.
D000328:Adult; D002648:Child; D002779:Cholestasis / Q000209:etiology* / Q000473:pathology; D005260:Female; D006506:Hepatitis A / Q000097:blood / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006508:Hepatitis Antibodies / Q000032:analysis; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged
D006508:Hepatitis Antibodies; D007075:Immunoglobulin M