Effect of a heme-peptide derived from cytochrome-c on lipid peroxidation. I. Effects on brain microsomes.
Heme-nonapeptide inhibits NADH and NADPH dependent lipid peroxidation of brain microsomes in the presence or absence of ADP-Fe complex. The transient accumulation of lipid peroxides during NADH or NADPH dependent, ADP-Fe stimulated lipid peroxidation, is inhibited by heme-nonapeptide. Oxygen consumption of brain microsomes in the presence of NADH or NADPH is stimulated by heme-nonapeptide. Reduction of cytochrome-c and nitro-tetrazolium-blue by O2- generated by xanthine oxidase is inhibited by heme-nonapeptide.
D000244:Adenosine Diphosphate / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003574:Cytochrome c Group / Q000494:pharmacology*; D045304:Cytochromes c; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008315:Malondialdehyde / Q000378:metabolism; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013481:Superoxides / Q000502:physiology
D003574:Cytochrome c Group; D008054:Lipid Peroxides; D010446:Peptide Fragments; C029936:adenosine diphosphate-ferric chelate; C046027:heme nonapeptide; D009243:NAD; D013481:Superoxides; D008315:Malondialdehyde; D009249:NADP; D000244:Adenosine Diphosphate; D045304:Cytochromes c