title: Adenovirus infection reverses the antiviral state induced by human interferon.
abstract: HeLa cells treated with human lymphoblastoid interferon do not synthesize poliovirus proteins. The antiviral state against poliovirus is reversed if cells are previously infected with adenovirus type 5. A late gene product seems to be involved in this reversion, since no effect is observed at early stages of infection or in the presence of aphidicolin.
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism; D000256:Adenoviridae / Q000235:genetics / Q000276:immunology*; D006367:HeLa Cells / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D009843:Oligoribonucleotides / Q000378:metabolism; D017955:Poliovirus / Q000276:immunology / Q000378:metabolism; D018139:Simplexvirus / Q000276:immunology; D014762:Viral Interference; D014764:Viral Proteins / Q000096:biosynthesis
chemical_list: D000227:Adenine Nucleotides; D007370:Interferon Type I; D009843:Oligoribonucleotides; D014764:Viral Proteins; C023505:2',5'-oligoadenylate