[Effect of dioxidine, antineoplastic agents and other mutagens on the precise excision of Tn1 and Tn10 transposons in E. coli K12].
Induction of precise excision of transposons Tn1 and Tn10 from the genes met::Tn1 and cys::Tn10 by chemical agents, having mutagenic and DNA damaging activities, has been studied. The drugs dioxydin, NMU, photrin, phopurine, thiophosphamid, rongeron as well as sodium azide, 2-NP, DDDTDP are shown to differ in their ability to stimulate the precise excision of transposons of different classes and in the efficiency of stimulated process. Results of the present paper are in proof of the possible using of experimental model, based on registering the precise excision of transposons, for screening the mutagenic and cancerogenic activities of chemical agents from the environment.
D000970:Antineoplastic Agents / Q000633:toxicity*; D004251:DNA Transposable Elements / Q000187:drug effects* / Q000528:radiation effects; D004926:Escherichia coli / Q000235:genetics*; D009153:Mutagens; D009154:Mutation; D011810:Quinoxalines / Q000633:toxicity*; D014466:Ultraviolet Rays
D000970:Antineoplastic Agents; D004251:DNA Transposable Elements; D009153:Mutagens; D011810:Quinoxalines; C001077:dioxidine
Vliianie dioksidina, protivoopukholevykh preparatov i drugikh mutagennykh soedinenniĭ na tochnoe iskliuchenie transpozonov Tn1 i Tn10 u E. coli K12.