Macrophage-resistant murine simian virus 40 tumors express a retroviral type-specific gp70.
Prototype macrophage-resistant and -sensitive cells were subcloned. Among several subclones of the resistant line, one subclone showed partial reversion to a sensitive phenotype. Analysis with monoclonal antibodies specific for different serotypes of endogenous murine leukemia virus revealed that expression of only one such gp70 (gp70a) correlated with the macrophage-resistant phenotype.
D000818:Animals; D000911:Antibodies, Monoclonal; D003602:Cytotoxicity, Immunologic; D005786:Gene Expression Regulation; D006023:Glycoproteins / Q000235:genetics* / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000235:genetics / Q000276:immunology*; D012191:Retroviridae Proteins / Q000235:genetics* / Q000276:immunology; D013539:Simian virus 40
D000911:Antibodies, Monoclonal; D006023:Glycoproteins; D012191:Retroviridae Proteins