[Effect of metronidazole and local irradiation of the tumor on paramagnetic metal complexes of the liver and tumor tissues].
A study was made of changes in the intensity of the ESR signals in tissues of sarcoma-37 and liver of mice after radiation of the tumor, administration of metronidazole, and after the combined effect of the two factors. The most pronounced changes in the ESR signals were induced by metronidazole. An appreciable increase in the content of nitrosyl complexes in the tumor was noted after the combined effect of metronidazole and radiation which was indicative of the radiation-induced formation of a large number of metronidazole anion-radicals in the tumor.
D000818:Animals; D001665:Binding Sites / Q000187:drug effects / Q000528:radiation effects; D004578:Electron Spin Resonance Spectroscopy; D007700:Kinetics; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D008667:Metalloproteins / Q000378:metabolism / Q000528:radiation effects*; D008795:Metronidazole / Q000627:therapeutic use*; D051379:Mice; D008815:Mice, Inbred Strains; D012511:Sarcoma 37 / Q000378:metabolism / Q000532:radiotherapy*; D012513:Sarcoma, Experimental / Q000532:radiotherapy*; D013997:Time Factors
D008667:Metalloproteins; D008795:Metronidazole
Vliianie metronidazola i lokal'nogo oblucheniia opukholi na paramagnitnye metallokompleksy tkaneĭ pecheni i opukholi.