Anti-shock effect of ACTH-(1-24) in rats: comparison between intracerebroventricular and intravenous route of administration.
In an experimental model of hypovolemic shock in rats, produced by withdrawing about 50% of the estimated total blood volume, and causing 100% deaths within 30 min, ACTH-(1-24) dose-dependently improved arterial and pulse pressure and increased survival rate. The intracerebroventricular (i.c.v.) route of administration was more effective than the intravenous (i.v.) route: at the dose of 24 micrograms/kg, 45% and 91% of rats were still surviving 2 hr after i.v. and i.c.v. treatment, respectively. At higher doses of ACTH-(1-24), the survival rate rose to 100% regardless of the route of administration, but arterial pressure increased more after i.c.v. than after i.v. injection. These data suggest that the CNS plays an important role in the anti-shock effect of ACTH.
D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003366:Cosyntropin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D011674:Pulse / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012769:Shock / Q000188:drug therapy* / Q000503:physiopathology
D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone