[An acute recurrence of focal-segmental glomerulosclerosis in a kidney transplanted from mother to son with a rapid decline in kidney function].
A case is presented of a 19-year-old man suffering from focal-segmental glomerulosclerosis with terminal chronic renal failure to whom a kidney taken from his mother was transplanted. There was high blood-group and tissue compatibility between mother and son. The initial result was good, the transplanted kidney functioned well-diuresis of 3300 ml with high proteinuria. Gradually the diuresis fell to 100-200 ml. From the 29th day following the transplantation pulse urbason therapy was applied for 3 days but without effect. This led to the resumption of hemodialysis and removal of the transplanted kidney. The microscopic examination of the kidney revealed massive focal-segmental glomerulosclerosis which had led to terminal chronic renal failure. The rapid severe relapse of the disease in the transplanted kidney is explained with the malignancy of the disease and the very high compatibility between donor and recipient. It is recommended that renal transplantation in patients with focal-segmental glomerulosclerosis should not be performed with a kidney taken from a parent.
D000208:Acute Disease; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology*; D005923:Glomerulosclerosis, Focal Segmental / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000473:pathology / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D011183:Postoperative Complications / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D012008:Recurrence
D006680:HLA Antigens
Ostŭr retsidiv na ognishtno-segmentna glomeruloskleroza v transplantiran bŭbrek ot maĭka na sin s bŭrzo otpadane na bŭbrechnata funktsiia.