Delayed neurotoxicity after ingestion of carbamate pesticide.
We studied a patient who ingested 27 gm (500 mg/kg) of carbaryl (1-naphthyl N-methylcarbamate), a popular carbamate pesticide. After he recovered from acute cholinergic toxicity, acute weakness of arms and legs was accompanied by electrophysiologic findings consistent with axonal peripheral neuropathy. Recovery began at 1 week and continued for 9 months. A similar delayed neuropathy has been described with organophosphates but not with carbamate insecticides.
D000328:Adult; D012721:Carbaryl / Q000506:poisoning*; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D006801:Humans; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology
D002800:Cholinesterase Inhibitors; D012721:Carbaryl