Effect of food intake on blood lead concentration in workers occupationally exposed to lead.
Results from a cross-sectional study showed the concentration of lead in the blood of male workers, aged 20-55 years, occupationally exposed to lead in a steel factory, to be negatively correlated with the daily nutritional content of dietary fiber, iron and vitamin B1 (thiamine) intake. Furthermore, in experiments with rats injected subcutaneously with lead acetate, lead levels in blood and femur of animals on a vitamin-rich laboratory chow were lower than those fed a general laboratory chow. Moreover, in the group fed the vitamin-rich chow, lead excretion in feces increased, while excretion in urine did not. These results suggest that lead excretion from the body may be increased by a high intake of nutrients such as thiamine, iron and fiber, that lead excretion in feces via bile may be enhanced by a large intake of vitamins such as thiamine and that accordingly the lead concentration in the blood of the workers is reduced.
D000328:Adult; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000032:analysis; D004032:Diet; D004043:Dietary Fiber; D004781:Environmental Exposure; D005243:Feces / Q000032:analysis; D006801:Humans; D007279:Injections, Subcutaneous; D007854:Lead / Q000032:analysis / Q000097:blood*; D008099:Liver / Q000032:analysis; D008297:Male; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains; D014815:Vitamins / Q000494:pharmacology*
D004043:Dietary Fiber; D014815:Vitamins; D007854:Lead