Regulation of mitochondrial proteolysis. Selective degradation of inner membrane polypeptides.
The in vitro degradation of respiratory chain polypeptide components by a proteinase associated with the intermembrane space fraction was studied in rat liver mitochondria. Differences in susceptibility to proteolysis were detected by gel analysis after electrophoretic separation of the degraded polypeptides. A 55 kDa subunit is protected from proteolysis by the ATP molecule.
D000818:Animals; D006706:Homeostasis; D007425:Intracellular Membranes / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013367:Submitochondrial Particles / Q000378:metabolism*; D013384:Succinate Cytochrome c Oxidoreductase / Q000378:metabolism
D008565:Membrane Proteins; D013384:Succinate Cytochrome c Oxidoreductase; D010447:Peptide Hydrolases