title: An alpha-fucosidase pseudogene on human chromosome 2.
abstract: In Chinese hamster-human hybrids with overlapping translocations, the major site of hybridization of a cDNA clone for the liver form of human alpha-L-fucosidase was 1p36.13----1p34, consistent with hybridization to the FUCAl locus. No hybridization to the FUCA2 locus on chromosome 6 was observed. Hybridization to a genomic sequence on chromosome 2 was, however, detected, thus defining a new FUCA-like locus. The restriction map of the alpha-fucosidase cDNA could be exactly superimposed upon its region of homology within a genomic clone containing this FUCA-like locus, suggesting that it is a processed pseudogene.
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005796:Genes; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D009693:Nucleic Acid Hybridization; D005644:alpha-L-Fucosidase / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D004247:DNA; D004262:DNA Restriction Enzymes; D005644:alpha-L-Fucosidase