Immunologic patterns in CAPD patients with peritonitis.
Alterations of peritoneal defense mechanisms, i.e. opsonization, phagocytosis, and bacterial killing, may be responsible for the high peritonitis rate in a subgroup of CAPD patients. Peritonitis incidence and in vitro bacterial opsonization has been shown to depend on IgG concentrations in the dialysate and on the ability of macrophages to produce fibronectin. Additionally, a high peritonitis incidence is associated with decreased bactericidal activity of macrophages; thus infective organisms may survive intracellularly despite intact phagocytosis. In some CAPD patients a disturbance in lymphokine and monokine release may be responsible for the reduced ability of their macrophages to kill bacteria.
D001770:Blood Bactericidal Activity; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008264:Macrophages / Q000276:immunology*; D009895:Opsonin Proteins / Q000276:immunology; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D010537:Peritoneum / Q000276:immunology; D010538:Peritonitis / Q000209:etiology / Q000276:immunology*; D010587:Phagocytosis
D009895:Opsonin Proteins