title: [Comparative study of the analgesic, sedative and myorelaxant effects of GABA-positive preparations].
abstract: It was shown in experiments on rats that the analgesic effect of GABA-positive drugs is followed by sedative and myorelaxant manifestations, however there is no direct relationship between the effects. Bicuculline significantly attenuates analgesia induced by THIP, gamma-acetylenic-GABA and depakin in the test of vocalization but enhances their analgesic activity in the tail-flick test. The involvement of individual subtypes of GABA receptors in mediation of analgesic and general depressant effects of GABA-positive drugs was discussed.
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D009129:Muscle Tonus / Q000187:drug effects; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects; D014828:Vocalization, Animal / Q000187:drug effects
chemical_list: D000700:Analgesics; D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central; D011963:Receptors, GABA-A; D000612:4-Aminobutyrate Transaminase
vernacular_title: Sravnitel'noe izuchenie boleutoliaiushchego, sedativnogo i miorelaksiruiushchego éffektov GAMK-pozitivnykh preparatov.