Induction of the aromatic hydrocarbon receptor by trans-4-acetylaminostilbene in rat liver. Comparison with other aromatic amines.
The effect of the aromatic amines 2-acetylaminofluorene (AAF), 2-acetylaminophenanthrene (AAP) and trans-4-acetylaminostilbene (AAS) on the rat hepatic aromatic hydrocarbon (Ah) receptor level was studied. 3-Methylcholanthrene (MC), as a known receptor ligand, was used as a control. The complete liver carcinogen AAF and MC did not alter significantly the hepatic receptor concentration. In contrast, the strong liver tumor initiator AAS doubled the hepatic Ah receptor level when a dose of 20 mumol/kg was administered for 5 days. AAP increased the amount of the receptor 1.5-fold.
D015073:2-Acetylaminofluorene / Q000633:toxicity; D000818:Animals; D002273:Carcinogens; D005260:Female; D008099:Liver / Q000032:analysis / Q000187:drug effects*; D008748:Methylcholanthrene / Q000633:toxicity; D009153:Mutagens; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug / Q000032:analysis / Q000187:drug effects*; D013267:Stilbenes / Q000633:toxicity*
D002273:Carcinogens; D009153:Mutagens; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug; D013267:Stilbenes; C028520:4-acetylaminostilbene; D008748:Methylcholanthrene; D015073:2-Acetylaminofluorene