Local humoral and cellular responses in Aujeszky's disease virus infection in pigs.
Mucosal and tracheal washings from pigs vaccinated parenterally and intranasally with Aujeszky's disease virus were tested for specific anti-Aujeszky's disease virus responses. Antibody tests included complement dependent antibody lysis, antibody dependent cellular cytotoxicity, virus neutralisation, and anti-Aujeszky's disease virus IgA and IgG levels. There was no correlation between the levels of these antibodies and protection from subsequent challenge. Direct lymphocyte cytotoxicity against cells infected with Aujeszky's disease virus was found in lymph nodes draining the tonsillar area.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000920:Antibody-Dependent Cell Cytotoxicity; D003602:Cytotoxicity, Immunologic; D011558:Herpesvirus 1, Suid / Q000276:immunology*; D007111:Immunity, Cellular; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D009500:Neutralization Tests; D011557:Pseudorabies / Q000276:immunology*; D013552:Swine; D013553:Swine Diseases / Q000276:immunology*; D014132:Trachea / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D014765:Viral Vaccines