Immune response to rotavirus polypeptides after vaccination with heterologous rotavirus vaccines (RIT 4237, RRV-1).
The antibody response to individual rotavirus polypeptides after vaccination with live attenuated heterologous rotavirus vaccines was studied with a radioimmunoprecipitation assay (RIPA). Following vaccination with bovine rotavirus strain RIT 4237 and rhesus monkey rotavirus strain RRV-1, an antibody response was demonstrated mainly against the inner capsid polypeptides VP2 and VP6 and to a lesser extent against VP3/VP4. There was no qualitative difference between the vaccines in the antibody response; both vaccines induced antibodies against the same polypeptides. Quantitatively the antibody response to RRV-1 was somewhat stronger. All prevaccination sera contained by RIPA low levels of rotavirus antibodies. The effect of these antibodies on the 'take' of the vaccines is discussed.
D000914:Antibodies, Viral / Q000096:biosynthesis*; D003429:Cross Reactions; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007223:Infant; D010455:Peptides / Q000276:immunology*; D012401:Rotavirus / Q000276:immunology*; D013045:Species Specificity; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D010455:Peptides; D014613:Vaccines, Attenuated; D014764:Viral Proteins; D014765:Viral Vaccines