title: Use of antimicrobial containing acrylic strips in the treatment of chronic periodontal disease. A three month follow-up study.
abstract: Local antimicrobial therapy has been considered for use in the treatment of chronic periodontal disease. This study evaluated chlorhexidine, metronidazole, and tetracycline delivered into periodontal pockets in an acrylic resin vehicle and compared the results with root planed and untreated sites over a three-month follow-up period. One site per patient where pocketing greater than or equal to 6 mm associated with a single rooted tooth was randomly allocated to one of the five possible regimens. Baseline and follow-up measurements included probing depth, loss of attachment, bleeding on probing, crevicular fluid flow, and dark-field microscopy of a subgingival plaque sample. Intratreatment evaluations revealed no significant changes in any parameter for untreated sites. Significant improvements in many parameters occurred with all four therapies although the magnitude and duration were greater in metronidazole and root planing groups. The more important intertreatment comparisons indicated that most treatments produced significant benefits compared with the control group; however, again these were greater with metronidazole and root planing. Furthermore, significantly greater effects were noted for metronidazole and root planing compared with tetracycline and more particularly chlorhexidine. It is concluded that some locally delivered antimicrobials alone may be useful in the treatment of chronic periodontal disease. However, at this time local antimicrobial therapy should be considered as adjunctive to conventional debridement techniques.
mesh_terms: D000328:Adult; D000368:Aged; D002710:Chlorhexidine / Q000008:administration & dosage*; D002908:Chronic Disease; D012534:Dental Scaling; D004343:Drug Implants; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008768:Methylmethacrylates; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D010510:Periodontal Diseases / Q000188:drug therapy* / Q000628:therapy; D010514:Periodontal Pocket / Q000188:drug therapy / Q000473:pathology; D013752:Tetracycline / Q000008:administration & dosage*; D014092:Tooth Root / Q000601:surgery
chemical_list: D004343:Drug Implants; D008768:Methylmethacrylates; D008795:Metronidazole; C009931:poly(ethylmethacrylate); D013752:Tetracycline; D002710:Chlorhexidine