[Urinary steroid profile in Cushing syndrome and in tumors of the adrenal cortex].
The analysis of 24-h excretion profiles of urinary steroids in 18 patients suffering from Cushing's syndrome or adrenocortical tumors revealed typical patterns when compared to 37 healthy control persons, 24 patients with obesity, and 6 patients with hirsutism. The validation of eight criteria--increased excretion of free cortisol, 6 beta-hydroxycortisol, 20 alpha-dihydrocortisol, 11 beta-hydroxyandrosterone, and 3 beta-hydroxy-5-en steroids, decreased ratio of tetrahydrocortisone (THE) to tetrahydrocortisol (THF), and increased ratios of THF to allotetrahydrocortisol (a-THF) and metabolites of androgens (AM) to metabolites of cortisol (CM)--afforded reliable detection of disorders in steroid biosynthesis. The analysis of urinary steroid profiles can therefore be recommended as a screening procedure in patients with clinical symptoms of disorders in steroid production and/or metabolism.
D015065:17-Hydroxycorticosteroids / Q000652:urine*; D015068:17-Ketosteroids / Q000652:urine*; D000293:Adolescent; D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000652:urine*; D000324:Adrenocorticotropic Hormone / Q000652:urine; D000328:Adult; D002648:Child; D003480:Cushing Syndrome / Q000175:diagnosis / Q000652:urine*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D008297:Male
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
Harnsteroidprofile bei Cushing Syndrom und Tumoren der Nebennierenrinde.