title: Liver-cell adenoma. Case report.
abstract: A young woman taking oral contraceptives presented with acute, severe abdominal pain. A liver-cell adenoma (weight 1.6 kg), with intrahepatic bleeding and necrosis, was enucleated at elective laparotomy. The clinical presentation of liver-cell adenoma, ranging from incidental finding to sudden death, is reviewed and the evidence linking oral contraceptives to the tumour is discussed. Reported cases of symptomatic liver-cell adenoma have numerically declined in the past decade. Acute surgical treatment is indicated only to control bleeding. In addition to withdrawal of oral contraceptive medication, enucleation of the tumour or hepatic resection is generally recommended as elective, definitive treatment.
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced*; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D004997:Ethinyl Estradiol / Q000009:adverse effects; D005260:Female; D006801:Humans; D016912:Levonorgestrel; D008099:Liver / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000139:chemically induced*; D009644:Norgestrel / Q000009:adverse effects; D011877:Radionuclide Imaging
chemical_list: D003277:Contraceptives, Oral, Combined; D009644:Norgestrel; D004997:Ethinyl Estradiol; D016912:Levonorgestrel