Possible correction of defective polymorphonuclear cell functions in type-2 diabetes mellitus by met-enkephalin.
In vitro pretreatment with Met-Enk of human PMNLs obtained from patients suffering from type-2 diabetes mellitus resulted in the normalization of the ROS generating system. It is assumed that Met-Enk has a modulating effect on the arachidonic acid metabolism, with a consecutive increase of the LTB4 release.
D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000276:immunology*; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology* / Q000502:physiology; D012016:Reference Values; D013481:Superoxides / Q000097:blood
D013481:Superoxides; D004744:Enkephalin, Methionine