Local GABAergic modulation of noradrenaline release in the rat olfactory bulb measured on superfused slices.
Ascending noradrenergic projections from locus coeruleus reaching the rat olfactory bulb (OB) synapse onto gamma-aminobutyric acid (GABA)-ergic interneurons. We tested the hypothesis that these interneurons could locally modulate noradrenaline (NA) release. On superfused OB slices, GABA (10, 100 and 1000 microM) enhanced potassium-evoked release of newly accumulated [3H]NA. This raises the possibility that GABAergic interneurons could establish a functional link between olfactory deutoneuron activity and NA release in the rat OB.
D000818:Animals; D066298:In Vitro Techniques; D007395:Interneurons / Q000187:drug effects / Q000502:physiology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D009830:Olfactory Bulb / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D010477:Perfusion; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology / Q000502:physiology*
D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D011188:Potassium; D009638:Norepinephrine