title: [Function of the hypophyseal-ovarian-adrenal system in trophoblastic disease].
abstract: Hyperproduction of chorionic gonadotropin was shown to be the first link in the chain of hormonal disturbances involved in trophoblastic disease, which induced changes of pituitary gonadotropic function. Ovarian function is affected by disturbances in trophoblastic and pituitary gonadotropic functions and depends on the extension and severity of the disease. This makes a case for corrective hormonal therapy in chorionepithelioma patients resistant to cytostatic or substitution therapy with sex hormones and in whom ovaries have been removed during combined treatment.
mesh_terms: D000293:Adolescent; D000311:Adrenal Glands / Q000503:physiopathology*; D000328:Adult; D002822:Choriocarcinoma / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000503:physiopathology / Q000628:therapy; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010053:Ovary / Q000503:physiopathology*; D010902:Pituitary Gland / Q000503:physiopathology*; D011247:Pregnancy; D013997:Time Factors; D014328:Trophoblastic Neoplasms / Q000503:physiopathology* / Q000628:therapy; D014594:Uterine Neoplasms / Q000503:physiopathology* / Q000628:therapy
vernacular_title: Funktsional'noe sostoianie gipofizarno-ovarial'no-nadpochechnikovoĭ sistemy pri trofoblasticheskoĭ bolezni.