Neurotransmission in the pedunculopontine nucleus and pilocarpine-induced motor limbic seizures in rats.
Systemic injection of the cholinergic agonist, pilocarpine (380 mg/kg, i.p.) initiates a sequence of events leading to motor limbic seizure activity. Focal injection of the excitatory amino acid antagonist, 2-amino-7-phosphonoheptanoic acid (50 pmol-1 nmol) into the pedunculopontine nucleus (PPN), prior to pilocarpine injection, results in a powerful anticonvulsant action. The GABA agonist, muscimol (25-50 pmol) also afforded protection against pilocarpine-evoked convulsions when injected focally into the PPN. The results suggest that an overall inhibition of PPN output neurons is required for anticonvulsant action.
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D001479:Basal Ganglia / Q000503:physiopathology*; D002531:Cerebellum / Q000503:physiopathology*; D008032:Limbic System / Q000503:physiopathology; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology*; D011149:Pons / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000187:drug effects
D000596:Amino Acids; D010862:Pilocarpine; D009118:Muscimol; D015763:2-Amino-5-phosphonovalerate; C031231:2-amino-7-phosphonoheptanoic acid