title: Superoxide radical initiates the autoxidation of dihydroxyacetone.
abstract: The aerobic xanthine oxidase reaction causes the cooxidation of dihydroxyacetone in a process which is strongly inhibited by superoxide dismutase but not by catalase, HO X scavengers, or iron-inactivating chelating agents. Several molecules of the sugar can be oxidized per O2- introduced. A free radical chain mechanism, in which O2- acts both as an initiator and as a chain propagator, is proposed. Simple sugars capable of tautomerizing to enediols may now be added to the list of biologically relevant targets for O2-.
mesh_terms: D002374:Catalase / Q000494:pharmacology; D002614:Chelating Agents / Q000494:pharmacology; D004098:Dihydroxyacetone / Q000378:metabolism*; D005609:Free Radicals; D006863:Hydrogen-Ion Concentration; D006878:Hydroxides / Q000494:pharmacology; D017665:Hydroxyl Radical; D007700:Kinetics; D010084:Oxidation-Reduction; D013482:Superoxide Dismutase / Q000494:pharmacology; D013481:Superoxides / Q000494:pharmacology*; D014306:Trioses / Q000378:metabolism*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D002614:Chelating Agents; D005609:Free Radicals; D006878:Hydroxides; D014306:Trioses; D013481:Superoxides; D017665:Hydroxyl Radical; D002374:Catalase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D004098:Dihydroxyacetone