title: The L1 family (KpnI family) sequence near the 3' end of human beta-globin gene may have been derived from an active L1 sequence.
abstract: We previously reported that some L1 family (KpnI family) members are closely associated with the Alu family sequence. To understand the details of the L1-Alu association, the structure of a L1-Alu unit downstream from the beta-globin gene was compared between human and primates. The results revealed that the L1-Alu-associated sequence was formed by the insertion of the L1 sequence, T beta G41, into the 3' poly A tract of the preexisting Alu family sequence. It was estimated that the T beta G41 sequence was inserted after the divergence of Old World monkeys and hominoids and before the divergence of orang-utan and common ancestor of other higher hominoids. From the calculation of the mutation rates of L1 sequences, it was suggested that the T beta G41 was derived from an active L1 sequence which was able to encode reverse transcriptase-related protein.
mesh_terms: D000818:Animals; D001483:Base Sequence; D004251:DNA Transposable Elements; D005914:Globins / Q000235:genetics*; D006801:Humans; D005810:Multigene Family; D010802:Phylogeny; D011323:Primates / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
chemical_list: D004251:DNA Transposable Elements; D005914:Globins