Dapsone neuropathy--report of three cases and pathologic features of a motor nerve.
We report the clinical features, electrophysiologic findings, and dapsone and isoniazid excretion studies in three young people who ingested excessive amounts (2-4 times the prescribed dose) of dapsone for hypopigmented macules and who developed, subacutely, progressive motor neuropathy a few months later. Pathologic studies on a biopsied motor nerve confirmed the electrophysiologic conclusion of distal motor axonopathy. All made a rapid recovery in a few months after dapsone was stopped, although electrical abnormalities persisted. One patient was a rapid acetylator of isoniazid.
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003622:Dapsone / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007918:Leprosy / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009046:Motor Neurons / Q000187:drug effects*; D009431:Neural Conduction / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D011041:Poisoning; D013979:Tibial Nerve / Q000473:pathology
D003622:Dapsone