[Induction of blood plasma carboxycathepsin (angiotensin I-converting enzyme) in normo- and hypertensive rats in response to a single administration of captopril].
The experiments were carried out to elucidate the effect of carboxycathepsin (CC) activity inhibition by a specific inhibitor--captopril--on plasma enzyme concentration in normotensive rats and rats with renovascular hypertension. A single oral administration of captopril (10 mg/kg body weight) produced an increase in CC concentration in both hypertensive and sodium-depleted normotensive rats with a parallel decrease in arterial pressure, but had no effect on sodium-repleted normotensive rats. It is suggested that the increase in plasma CC concentration is a compensatory response to the inhibition of CC activity by captopril; it is also possible that the increase observed reflects the state of renin-angiotensin system.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D004039:Diet, Sodium-Restricted; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006978:Hypertension, Renovascular / Q000201:enzymology* / Q000503:physiopathology; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis* / Q000097:blood; D051381:Rats; D013997:Time Factors
D002216:Captopril; D007703:Peptidyl-Dipeptidase A
Induktsiia karboksikatepsina (angiotenzin-I-prevrashchaiushchego fermenta) plazmy krovi normo- i gipertenzivnykh krys v otvet na odnokratnoe vvedenie kaptoprila.