Tricyclic therapy of the DSM-III anxiety disorders: a review with implications for further research.
Existing data suggests dramatic efficacy for all tested tricyclics in disorders involving spontaneous panic attacks; moderate efficacy for clomipramine but not other tricyclics in obsessive-compulsive patients; possible, but as yet not well established, tricyclic efficacy in generalized anxiety; and lack of efficacy in simple phobias. Further studies in all DSM-III Anxiety Disorders are both warranted and required to answer the nosological, pathophysiological and treatment questions raised by these findings.
D000293:Adolescent; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy*; D002648:Child; D002997:Clomipramine / Q000627:therapeutic use; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy; D010200:Panic / Q000187:drug effects; D010698:Phobic Disorders / Q000188:drug therapy
D000929:Antidepressive Agents, Tricyclic; D002997:Clomipramine