title: Use of monoclonal antibody HMB-45 in the cytologic diagnosis of melanoma.
abstract: The value of mouse monoclonal antibody (MAb) HMB-45 for the diagnosis of melanoma was retrospectively evaluated in cytologic preparations. Twenty-two (68.7%) of the 32 melanoma cases studied reacted with MAb HMB-45 while none of the 36 nonmelanoma tumors stained with this antibody. These results indicate that MAb HMB-45 can be helpful in the diagnosis of melanoma, especially in those patients who have no clinical indications of having a metastatic melanoma or in some cases in which the presence of melanin cannot be demonstrated by special histochemical stains.
mesh_terms: D000911:Antibodies, Monoclonal; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008543:Melanins / Q000032:analysis; D008545:Melanoma / Q000032:analysis / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D012189:Retrospective Studies; D009418:S100 Proteins / Q000032:analysis
chemical_list: D000911:Antibodies, Monoclonal; D008543:Melanins; D009418:S100 Proteins