title: Induction by fibroblast growth factor of angiotensin converting enzyme in vascular endothelial cells in vitro.
abstract: Induction of vascular endothelial cells with pituitary fibroblast growth factor (FGF) provoked an increase in angiotensin converting enzyme activity. The stimulatory effect of FGF on ACE activity was dose-dependent (ED50 = 1.0 ng/ml). Our results suggest a possible role for pituitary FGF in regulation of ACE production in vascular endothelial cells.
mesh_terms: D000803:Angiotensin I / Q000378:metabolism; D000804:Angiotensin II / Q000032:analysis; D000818:Animals; D001011:Aorta; D002216:Captopril / Q000494:pharmacology; D002478:Cells, Cultured; D004492:Edetic Acid / Q000494:pharmacology; D004727:Endothelium / Q000187:drug effects / Q000201:enzymology*; D004790:Enzyme Induction; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D006133:Growth Substances / Q000494:pharmacology; D007700:Kinetics; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis*; D013552:Swine
chemical_list: D006133:Growth Substances; D000804:Angiotensin II; D005346:Fibroblast Growth Factors; D000803:Angiotensin I; D004492:Edetic Acid; D002216:Captopril; D007703:Peptidyl-Dipeptidase A