Effects of arginine-vasopressin and ACTH 4-10 on acquisition of active avoidance response in rats with alcohol pretreatment in prenatal and adult age.
Alcohol administration in drinking water to mother rats during gestation resulted in a permanent learning deficit of the offspring when behavioural reactions were tested in active avoidance conditioned reflex situation in adult age. A similar deficit of learning capacity was observed in adult rats following alcohol administration for two weeks; the acquisition of active avoidance response was tested later. Administration of arginine-vasopressin and ACTH 4-10 during behavioural test led to a significant improvement of learning ability of the animals pretreated with alcohol. The observations indicate that the ethanol-induced deficit of learning capacity involves peptidergic mechanisms and the behavioural manifestations following chronic alcohol treatment are not irreversible processes.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000437:Alcoholism / Q000150:complications / Q000523:psychology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D005260:Female; D007859:Learning Disabilities / Q000209:etiology / Q000517:prevention & control; D008297:Male; D008431:Maternal-Fetal Exchange; D010446:Peptide Fragments / Q000494:pharmacology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000523:psychology; D051381:Rats
D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; D003894:Deamino Arginine Vasopressin; C011394:ACTH (4-10)