Model for 82Sr/82Rb generator elution profiles: a secondary approach to radioassay/dosimetry.
Static (dose calibrator) assays of 82Rb bolus yield erroneous estimates of administered activity by ignoring the asymmetric output of 82Sr/82Rb generators. Though on-line monitoring of elution profile improves accuracy for quantitative purposes, it requires an elaborately shielded detector and associated electronics at patient-study site. Our alternative approach based on mathematical description of the dynamic characteristics of the generator accurately predicts elution profiles over a broad range of flow rates.
D006801:Humans; D008954:Models, Biological; D011829:Radiation Dosage; D011868:Radioisotopes; D011876:Radionuclide Generators; D012413:Rubidium; D013324:Strontium; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D011868:Radioisotopes; D012413:Rubidium; D013324:Strontium