title: Aminoglycoside nephrotoxicity and urinary excretion of N-acetyl-beta-D-glucosaminidase.
abstract: The purpose of this paper is to discuss briefly the mechanism of aminoglycosides nephrotoxicity. This kind of antibiotic seems to act preferentially on the phospholipid metabolism of the proximal tubular cell. A lysosomal enzyme, N-acetyl-beta-D-glucosaminidase, could be of interest in assessing this renal interference.
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine*; D000375:Aging / Q000652:urine; D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000633:toxicity; D004796:Clinical Enzyme Tests; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D007231:Infant, Newborn / Q000652:urine*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D008247:Lysosomes / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D006596:Hexosaminidases; D000118:Acetylglucosaminidase