[Pharmacologic modification of vigilance in the postnarcotic phase-- naloxone or physostigmine?].
The usefulness of physostigmine in reversing post-narcotic depression after general anaesthesia is well proven; so is that of naloxone, a specific opioid analgetics antagonist, in reversing neuroleptic anaesthesia effects. Morphine-like analgetics are widely used as premedication agents, too; on the other hand, physostigmine reverses opioids as well as other psychotropic and narcotic agents. For that reason, positive post-narcotic physostigmine effects could be due to its anti-opioid potency as well. In a double-blind, randomised study, physostigmine and naloxone were evaluated using a clinically based vigilance protocol, and compared with saline solution. Naloxone did not have remarkable advantages as compared with placebo, while physostigmine led to a significantly higher level of vigilance; moreover, that level was reached sooner. The positive effects of physostigmine in restoring a sufficient level of vigilance after general anaesthesia are, in respect of our findings, unrelated to its antagonism to morphine-like analgetics.
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001143:Arousal / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000008:administration & dosage*; D009294:Narcotics; D010830:Physostigmine / Q000008:administration & dosage*; D011897:Random Allocation
D009294:Narcotics; D009270:Naloxone; D010830:Physostigmine
Medikamentöse Beeinflussung der Vigilanz in der postnarkotischen Phase--Naloxone oder Physostigmin?