Effect of nickel chloride on streptozotocin-induced diabetes in rats.
The potential of nickel chloride to prevent streptozotocin-induced hyperglycemia was tested in rats in vivo. To induce diabetes, streptozotocin (100 mg/kg body weight) was injected as a single dose. Streptozotocin treatment resulted in a significant decrease in plasma insulin and ceruloplasmin, and pancreatic Cu, protein, and Cu-Zn superoxide dismutase activity. In rats treated with nickel chloride (10 mg/kg body weight) and streptozotocin, these values were comparable with those observed in control rats. The results indicate that nickel chloride injected before streptozotocin prevented streptozotocin-induced hyperglycemia, and suggest that the protective effect was related to Cu-Zn superoxide dismutase activity, mediated by copper.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D009532:Nickel / Q000494:pharmacology*; D010179:Pancreas / Q000201:enzymology; D013482:Superoxide Dismutase / Q000378:metabolism; D015032:Zinc
D001786:Blood Glucose; D007328:Insulin; C022838:nickel chloride; D003300:Copper; D009532:Nickel; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D015032:Zinc