Expression of CD 25 (Tac antigen) in lymphoid leukemias and non-Hodgkin lymphomas.
A monoclonal antibody to IL2 receptor Tac/CD 25 antigen was included in the phenotyping panel of 92 leukemic proliferations. Spontaneous expression of this molecule was observed in one disorder of T-phenotype only, but in 75% of B-chronic lymphocytic leukemia (CLL) and on cells from B-cell leukemic lymphomas. These findings provide further evidence for a non-T-cell restriction of IL2 receptor and raise the question of multiple gene derepression in hematologic disorders of B-lineage.
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis / Q000378:metabolism*; D001402:B-Lymphocytes / Q000378:metabolism*; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism*; D007945:Leukemia, Lymphoid / Q000276:immunology / Q000378:metabolism*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000378:metabolism*; D015375:Receptors, Interleukin-2; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D007376:Interleukin-2; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7