Exercise and small intestinal transit.
The transit of 99Tcm-labelled particles through the small intestine has been monitored in nine healthy subjects undergoing three levels of exercise. The mean +/- 1S.D. small intestine transit times under conditions of minimal, moderate and strenuous activity were 4.5 +/- 1.7 h, 5.4 +/- 2.5 h and 4.1 +/- 1.8 h, respectively. These findings indicate that the bioavailability of drugs from controlled release preparations passing through the small intestine is unlikely to be affected by variations in normal daily activity.
D000328:Adult; D005746:Gastric Emptying; D006801:Humans; D007421:Intestine, Small / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008863:Microspheres; D005082:Physical Exertion; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D013997:Time Factors
D013670:Sodium Pertechnetate Tc 99m