Spontaneous and induced interferon production by peripheral blood leucocytes from control population and patients with herpes genitalis.
The spontaneous and PHA induced levels of interferon were measured in peripheral blood leucocyte cultures of twenty-eight individuals diagnosed as positive for herpes genitalis, and in a group of control subjects. As reported by Cunningham and Merigan [1983] for herpes labialis, leucocytes from individuals with herpes genitalis produced low levels of interferon spontaneously; however, similar results were found for individuals within the control population. No statistically significant difference could be found for PHA induced interferon levels, antigen induced interferon levels, or helper/suppressor cell ratios between the herpes genitalis population and control population. Our results indicate that interferon does not play a major role in the latency or recurrence of herpes genitalis.
D000956:Antigens, Viral / Q000276:immunology; D002478:Cells, Cultured; D006558:Herpes Genitalis / Q000276:immunology*; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis* / Q000097:blood; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000097:blood; D007962:Leukocytes / Q000276:immunology*; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology; D018139:Simplexvirus / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000956:Antigens, Viral; D007370:Interferon Type I; D010835:Phytohemagglutinins; D007371:Interferon-gamma