title: [Collagenases in rheumatology].
abstract: An important role is supposed to be played by the collagenases in the physiological or pathological degradation of collagen. However, their exact effects in rheumatic diseases, especially in rheumatoid arthritis is still controversial. The aim of the authors is to give facts and datas up to date, about this important question of the pathogenic role of collagenases in rheumatoid arthritis, osteoarthritis and in several other rheumatic diseases.
mesh_terms: D001172:Arthritis, Rheumatoid / Q000201:enzymology / Q000503:physiopathology; D002356:Cartilage / Q000166:cytology / Q000201:enzymology; D002478:Cells, Cultured; D003094:Collagen / Q000276:immunology / Q000378:metabolism; D003095:Collagen Diseases / Q000201:enzymology / Q000276:immunology / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors / Q000502:physiology*; D009000:Monocytes / Q000502:physiology; D009504:Neutrophils / Q000201:enzymology; D012216:Rheumatic Diseases / Q000201:enzymology*; D013582:Synovial Fluid / Q000166:cytology / Q000201:enzymology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007375:Interleukin-1; D003094:Collagen; D003012:Microbial Collagenase
vernacular_title: Collagénases en rhumatologie.