[Characteristics of genome sequences in mouse spleen cells activated in virus-induced Rauscher leukemia].
The restriction analysis of BALB/c and AKR mice genome DNA was used to show the translocation and amplification of gene which is expressed with the Rauscher erythroleukemia as the 35S nuclear RNA. The homology of this RNA to 10 defined oncogenes was studied. It was found that the cDNA 35S RNA is efficiently hybridized only with v-sis oncogene. The clones homologous to the 35S RNA, v-sis oncogene and 3'-area of the Rauscher leukemia virus genome are isolated from the genes' library of mice erythroleukemic cells.
D000818:Animals; D001483:Base Sequence; D004262:DNA Restriction Enzymes; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics*; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics; D007942:Leukemia, Experimental / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes; D011925:Rauscher Virus; D012689:Sequence Homology, Nucleic Acid; D013154:Spleen / Q000032:analysis*
D004273:DNA, Neoplasm; D004262:DNA Restriction Enzymes
Kharakteristika genomnykh posledovatel'nosteĭ kletok selezenki mysheĭ, aktiviruiushchikhsia pri virusindutsirovannom leĭkoze Raushera.