title: Tyrosine kinases in control of cell growth and transformation.
abstract: The growth of normal cells in tissues is strictly controlled, partly through intercellular communication by polypeptide growth factors. Malignantly transformed cells are independent from external growth factors to a certain extent, but their mechanisms for achieving growth autonomy differ from case to case. Several of the oncogene-encoded proteins are known to participate in the hormonal regulation of cell growth (for a recent review on tyrosine kinase oncogenes see ref. 21). Recent advances in molecular biology have shown important mechanisms for cell emancipation from growth regulatory hormonal signaling systems. A few such examples are discussed below.
mesh_terms: D002471:Cell Transformation, Neoplastic; D066246:ErbB Receptors / Q000032:analysis; D006133:Growth Substances / Q000502:physiology*; D009154:Mutation; D009857:Oncogenes; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000032:analysis; D016184:Receptors, Colony-Stimulating Factor
chemical_list: D006133:Growth Substances; D011956:Receptors, Cell Surface; D016184:Receptors, Colony-Stimulating Factor; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases