Clinical comparison of topical solutions containing trimethoprim in treating ocular surface bacterial infections.
Thirty-nine patients with bacterial ocular surface infections (conjunctivitis, blepharitis or blepharoconjunctivitis) were evaluated after treatment with a topically applied ophthalmic solution containing trimethoprim. A combination of trimethoprim and polymixin B (TP) produced identical clinical and microbiologic responses when compared to a solution containing, in addition to trimethoprim and polymyxin B, sulfacetamide. The sulfa component was not essential to produce desired clinical and microbiologic results.
D000287:Administration, Topical; D001424:Bacterial Infections / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005128:Eye Diseases / Q000188:drug therapy*; D005500:Follow-Up Studies; D006801:Humans; D011112:Polymyxin B / Q000008:administration & dosage / Q000627:therapeutic use; D011897:Random Allocation; D013409:Sulfacetamide / Q000008:administration & dosage / Q000627:therapeutic use; D014295:Trimethoprim / Q000008:administration & dosage / Q000627:therapeutic use*
D013409:Sulfacetamide; D014295:Trimethoprim; D011112:Polymyxin B