title: WHO international reference reagents for bovine and porcine proinsulins.
abstract: Candidate preparations for International Reference Reagents (IRR) for immunoassays of bovine and porcine proinsulin were evaluated in an international collaborative study. With the authorization of the Expert Committee on Biological Standardization of WHO, the following preparations were established as IRRs: bovine proinsulin (code 84/514, defined ampoule content 25 micrograms) and porcine proinsulin (84/528, 20 micrograms). The content of ampoules of these materials is defined in terms of mass rather than international units of activity, therefore they are IRR rather than International Standards. Both preparations are intended as primary reference reagents for the calibration of immunoassays.
mesh_terms: D000818:Animals; D002138:Calibration; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D007118:Immunoassay; D007202:Indicators and Reagents; D007328:Insulin / Q000032:analysis / Q000592:standards; D011384:Proinsulin / Q000592:standards*; D012015:Reference Standards; D013552:Swine; D014944:World Health Organization
chemical_list: D007202:Indicators and Reagents; D007328:Insulin; D011384:Proinsulin