title: Effect of dietary acidification on kidney damage induced in immature chickens by excess calcium and infectious bronchitis virus.
abstract: Experiments were designed to evaluate the effect of dietary acidification on the development of kidney lesions induced by excess dietary calcium (Ca) and Gray strain infectious bronchitis virus (IBV). Specific pathogen-free (SPF) chicks and SPF chicks inoculated with Gray strain IBV were fed one of three diets: a commercial pullet grower ration (1% Ca); a commercial layer ration (3.25% Ca); or layer ration plus .5% ammonium chloride (acidified layer ration). Gray strain IBV significantly reduced total kidney weights in males, reduced total kidney weight as a percentage of body weight in males, increased the number of gross kidney lesions, and decreased the number of filtering nephrons when compared with uninoculated birds when both groups were fed the grower ration. The layer ration induced a 60% incidence of kidney lesions, caused a significant increase in kidney weight asymmetry ratios, and caused a 25% reduction in the number of filtering nephrons. Acidifying the layer ration significantly reduced the incidence of gross kidney lesions and reduced kidney weight asymmetry ratios, but did not prevent Ca-induced reductions in filtering nephrons.
mesh_terms: D000138:Acidosis / Q000139:chemically induced / Q000150:complications / Q000662:veterinary*; D000643:Ammonium Chloride / Q000009:adverse effects*; D000818:Animals; D002136:Calcium, Dietary / Q000009:adverse effects*; D002645:Chickens / Q000378:metabolism*; D003332:Coronaviridae; D003333:Coronaviridae Infections / Q000150:complications / Q000662:veterinary; D005260:Female; D001351:Infectious bronchitis virus; D007668:Kidney / Q000473:pathology*; D008297:Male; D011201:Poultry Diseases / Q000209:etiology* / Q000378:metabolism / Q000382:microbiology; D014545:Urinary Calculi / Q000209:etiology / Q000662:veterinary*
chemical_list: D002136:Calcium, Dietary; D000643:Ammonium Chloride