In vivo interaction of antibodies with cell surface proteins used as antigens.
Antibody interactions with cell membrane glycoproteins in vivo exhibit features of aggregation and capping with resultant shedding similar to those events described in several in vitro isolated cell systems. Requirements for divalent ligand binding and participation of cytoskeletal elements are demonstrated in vivo as well. Persistence of antigen in immune complexes with complement interaction in situ appear to be necessary to induce an inflammatory response in vivo. Abrogation of this response occurs when circumstances permit antigenic modulation with disappearance of the immune complex.
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000936:Antigen-Antibody Complex / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis* / Q000276:immunology; D002462:Cell Membrane / Q000201:enzymology / Q000276:immunology*; D004727:Endothelium / Q000201:enzymology; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000473:pathology; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000473:pathology; D008565:Membrane Proteins / Q000032:analysis* / Q000276:immunology; D008871:Microvilli / Q000648:ultrastructure; D007703:Peptidyl-Dipeptidase A / Q000032:analysis
D000906:Antibodies; D000936:Antigen-Antibody Complex; D000954:Antigens, Surface; D006023:Glycoproteins; D008565:Membrane Proteins; D007703:Peptidyl-Dipeptidase A