[Independent benzodiazepine and beta-carboline binding sites in the brain of aggressive and anxious-defensive mice].
Distribution of specific 3H-flunitrazepam and 3H-beta-carboline-3-carboxylate binding sites in the brain regions of aggressive and timid-defensive mice was investigated before and after subchronic injection of diazepam (5 mg/kg). The absence of differences between the affinity and concentration of 3H-flunitrazepam binding sites in diencephalon and brain cortex in aggressive and defensive mice may be explained by general benzodiazepine receptor reaction on isolation and agonistic interaction stress. Significant predominance of 3H-beta-carboline-3-carboxylate binding sites in the brain cortex, as compared to the concentration of 3H-flunitrazepam binding sites suggests the presence of specific binding sites for beta-carbolines, which have specific distribution in the brain.
D000374:Aggression / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001007:Anxiety / Q000187:drug effects / Q000502:physiology*; D001665:Binding Sites / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002243:Carbolines / Q000378:metabolism*; D003975:Diazepam / Q000494:pharmacology; D005445:Flunitrazepam / Q000378:metabolism; D008024:Ligands; D008297:Male; D051379:Mice; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*; D014316:Tritium
D002243:Carbolines; D008024:Ligands; D011963:Receptors, GABA-A; D014316:Tritium; D005445:Flunitrazepam; C024915:beta-carboline-3-carboxylic acid ethyl ester; D003975:Diazepam
Nezavisimye mesta sviazyvaniia benzodiazepinov i beta-karbolinov v golovnom mozge agressivnykh i trevozhno-zashchitnykh mysheĭ.