title: [The role of chromosome unwinding proteins in the regulation of DNA repair and replication].
abstract: DNA repair and replication are regulated by cellular capability to support the definite optimal level of single strand DNA binding optimal level of single strand DNA binding proteins (SSB). SSB deficiency as well as it's overproduction in the cell cause, by means of different mechanisms, the destruction of DNA macromolecules due to impairment in timing of the nucleotides hydrolysis and resynthesis reactions. This asynchronization hinders the normal processing of DNA repair and replication.
mesh_terms: D000818:Animals; D004265:DNA Helicases / Q000235:genetics*; D004260:DNA Repair; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D004265:DNA Helicases
vernacular_title: O roli khromosomnykh raspletaiushchikh belkov v reguliatsii protsessov reparatsii i replikatsii DNK.