[The role of adrenoreceptors in the mechanism of pharmacological action of cavinton].
Having studied the functional state of beta-adrenoreceptors in vitro by the radioligand (3H-dihydroalprenalol) method it has been shown that cavinton in the concentration of 2.5 X 10(-6) M considerably increases the affinity of beta-adrenoreceptors for the ligand. In the in vivo experiments on rats the intraperitoneal injection of cavinton in the dose of 2 mg/kg causes an increase in the affinity of synaptosomal beta-adrenoreceptors for the ligand 10 days after chronic administration without altering the concentration of the receptors (Bmax) themselves. 20 days after the injection of the drug the affinity still grows and this effect of cavinton is retained even 30 days after the injection.
D000818:Animals; D001667:Binding, Competitive; D004082:Dihydroalprenolol; D008297:Male; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000378:metabolism; D013570:Synaptic Membranes / Q000378:metabolism; D014665:Vasodilator Agents / Q000494:pharmacology*; D014748:Vinca Alkaloids / Q000494:pharmacology*
D011943:Receptors, Adrenergic, beta; D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C013983:vinpocetine; D004082:Dihydroalprenolol
Rol' adrenoretseptorov v mekhanizme farmakologicheskogo deĭstviia kavintona.