title: Infection with human parvovirus (B19), aplasia of the bone marrow and a rash in hereditary spherocytosis.
abstract: Infection with human parvovirus (HPV) B19 was diagnosed in persons with hereditary spherocytosis during an outbreak of erythema infectiosum. A 10-year-old boy had an aplastic crisis of the bone marrow and a maculopapular rash. His mother also had an aplastic crisis, fever, rash and a transiently acellular marrow. Another boy had an aplastic crisis, leucopenia and fever, but did not have a rash. Aplastic crisis and a rash have rarely before been observed together and attributed to infection with HPV.
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000150:complications*; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002648:Child; D004890:Erythema / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D010321:Parvoviridae / Q000276:immunology; D010322:Parvoviridae Infections / Q000150:complications* / Q000175:diagnosis / Q000635:transmission; D012874:Skin Diseases, Infectious / Q000150:complications* / Q000635:transmission; D013103:Spherocytosis, Hereditary / Q000150:complications* / Q000235:genetics
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral