Dextromethorphan inhibits NMDA-induced convulsions.
Dextromethorphan, its metabolite dextrorphan, phencyclidine, ketamine, MK-801, 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid and DL-2-amino-7-phosphonoheptanoic acid were evaluated for potency to antagonize N-methyl-D-aspartate-induced convulsions following intraperitoneal administration using male CF-1 mice. Whereas reference anticonvulsants (e.g., phenytoin) were ineffective in this model, dextromethorphan and all competitive and noncompetitive N-methyl-D-aspartate antagonists blocked seizures. The results are consistent with the interpretation that dextromethorphan elicits some of its pharmacological responses via an interaction with receptors for excitatory amino acids.
D000818:Animals; D000927:Anticonvulsants; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D003915:Dextromethorphan / Q000494:pharmacology*; D003986:Dibenzocycloheptenes / Q000494:pharmacology; D016291:Dizocilpine Maleate; D007981:Levorphanol / Q000031:analogs & derivatives*; D008297:Male; D051379:Mice; D016202:N-Methylaspartate; D011597:Psychomotor Performance / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced
D000927:Anticonvulsants; D003986:Dibenzocycloheptenes; D007981:Levorphanol; D001224:Aspartic Acid; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; D003915:Dextromethorphan