Deregulated c-fos expression interferes with normal bone development in transgenic mice.
Transgenic mice were generated expressing c-fos genes under the control of the human metallothionein promoter. Although high levels of c-fos messenger RNA were detectable in a variety of tissues, deregulated c-fos expression specifically interfered with normal bone development without inducing malignant tumours.
D000818:Animals; D001859:Bone Neoplasms / Q000235:genetics / Q000382:microbiology / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D003433:Crosses, Genetic; D005260:Female; D005786:Gene Expression Regulation; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics; D008815:Mice, Inbred Strains / Q000235:genetics*; D009857:Oncogenes; D010375:Pedigree; D009053:Sarcoma Viruses, Murine / Q000235:genetics*