title: Disappearance of Tc-99m HMDP tumor uptake in oat cell carcinoma after irradiation and chemotherapy.
abstract: Extraosseous localization of bone-seeking radiopharmaceuticals has been reported in various tumors, presumably on the basis of active calcium deposition in the tumors. We report a case of oat cell carcinoma in which the initial localization of Tc-99m-HMDP in the tumor disappeared after irradiation and chemotherapy. The disappearance of tracer uptake coincided with regression of the mass as seen in the chest radiograph. This finding may have potential application in determining tumor response to anticancer therapy.
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging* / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D011879:Radiotherapy Dosage; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives*
chemical_list: C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013669:Technetium Tc 99m Medronate