Linkage of cystic fibrosis locus and polymorphic DNA markers in 14 families.
Linkage relationships between the cystic fibrosis (CF) locus and three polymorphic DNA markers were examined in 14 families, five of which were of Hispanic origin. Tight linkage was found between the CF locus and MET (maximum lod score = 7.16 at theta = .001), and between CF and pJ3.11 (maximum lod score = 3.87 at theta = .001). We observed two recombinations between CF and collagen, yielding a maximum lod score of 0.359 at theta = .125, and one recombination in the cluster CF-MET-pJ3.11. Analysis by the seriation method indicates the order COL-pJ3.11-CF-MET.
D003550:Cystic Fibrosis / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D011110:Polymorphism, Genetic
D005819:Genetic Markers; D004247:DNA; D004262:DNA Restriction Enzymes