Variables predicting bacterial and fungal infections after allogeneic marrow engraftment.
Sixty-seven consecutive patients with aplastic anemia or leukemia who had been treated by allogeneic marrow transplantation and had survived for more than 1 month were surveyed in order to determine the incidence of nonviral infections occurring from 1 month to 3 years after transplantation. Twenty-eight of the 67 patients had one or more infections during this period. Around 20% suffered from pulmonary infections and 20% were classified as having a systemic infection. Ten patients died of bacterial or fungal infection, of whom 6 had graft-versus-host disease. In multivariate analyses acute graft-versus-host disease (P less than 0.0009), splenectomy (P less than 0.02), cytomegalovirus infection (P less than 0.05), and a low marrow cell dose (P less than 0.07) were correlated with nonviral infections.
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000150:complications / Q000628:therapy; D001424:Bacterial Infections / Q000209:etiology*; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology*; D011237:Predictive Value of Tests; D012306:Risk; D013156:Splenectomy / Q000009:adverse effects; D013223:Statistics as Topic