Reversal of depressed neutrophil superoxide production in Felty's syndrome after gold therapy.
Six patients with Felty's syndrome were reevaluated after a course of chrysotherapy. In 5 patients, white cells and absolute neutrophil counts had returned to normal. In 4 of these, there was significant concomitant improvement in neutrophil function as assessed by the ability of cells to generate superoxide radicals.
D005258:Felty Syndrome / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006052:Gold Sodium Thiomalate / Q000627:therapeutic use*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D013481:Superoxides / Q000096:biosynthesis*
D013481:Superoxides; D006052:Gold Sodium Thiomalate