title: Studies on the effects of oxamniquine on autonomic transmissions.
abstract: The effects of oxamniquine have been investigated on parasympathetic and sympathetic transmissions using in vitro and in vivo laboratory models. Oxamniquine (3.6 X 10(-5)-5.5 X 10(-4) M) depressed or abolished electrically-evoked contractions of the isolated chick esophagus and isolated vas deferens muscle preparations. At the same concentration (3.6 X 10(-5)-5.5 X 10(-4) M) levels, the drug also reduced or abolished the indirect, electrically-provoked twitches of the rat isolated phrenic nerve-hemidiaphragm muscle preparations and contractions of the cat nictitating membrane induced by pre-ganglionic cervical sympathetic nerve trunk electrical stimulation in vivo. These results strongly suggest blockade of sympathetic and parasympathetic transmissions by oxamniquine.
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D002415:Cats; D002645:Chickens; D004558:Electric Stimulation; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009600:Nitroquinolines / Q000494:pharmacology*; D010073:Oxamniquine / Q000494:pharmacology*; D010275:Parasympathetic Nervous System / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D013564:Sympathetic Nervous System / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D009600:Nitroquinolines; D010073:Oxamniquine