Perinatal lethal osteogenesis imperfecta: radiologic and pathologic evaluation of seven prenatally diagnosed cases.
The radiologic and pathologic characteristics of 7 cases of lethal osteogenesis imperfecta (OI), diagnosed prenatally by ultrasound in the 15th to 34th week, are described. They include four variants of the Sillence classification: types IIA, IIB, IIC, and type III. The radiologic criteria that differentiate these types of OI are described. The histopathology of the bones differed only slightly in types IIA, IIB, and III; OI type IIC, however, differed markedly from the other types.
D005260:Female; D005270:Femur Head / Q000196:embryology / Q000473:pathology; D005315:Fetal Diseases / Q000145:classification* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D006132:Growth Plate / Q000473:pathology; D006801:Humans; D008297:Male; D010013:Osteogenesis Imperfecta / Q000145:classification* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011859:Radiography; D014463:Ultrasonography