title: [Acute renal insufficiency and non-steroidal anti-inflammatory drugs].
abstract: Non-steroid anti-inflammatory drugs cause an increasing number of renal disorders because of their increasing use. In addition to a toxic or immuno-allergic mechanism common to many medications, the side-effects are essentially related to the inhibition of prostaglandins biosynthesis which play a major role as soon as the renal blood flow is compromised. Acute renal failure of hemodynamic origin, interstitial nephropathy with or without nephrotic syndrome are the most characteristic manifestations of the renal toxicity of non-steroid anti-inflammatory drugs.
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D009393:Nephritis / Q000139:chemically induced; D009404:Nephrotic Syndrome / Q000139:chemically induced
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
vernacular_title: Insuffisance rénale aiguë et anti-inflammatoires non stéroïdiens.