Common cytogenetic findings in primary breast cancer.
Five cases of breast cancer were cytogenetically studied by G-banding, using direct tumor preparations. Chromosomes involved in aberrations, according to frequency, were #1, #11, #3, #6, #5, and #17. In all five cases there were abnormalities of chromosomes #1 and #11. In each case chromosome #1 was involved in at least two different ways. In four cases abnormalities of chromosomes #11 exhibited nonrandom involvement of band q22-23. These findings confirm the role of chromosomes #1 and #11 in breast cancer and show that band 11q22-23, which has been reported to be an inheritable fragile site and is a specific breakpoint in acute leukemia, also may be specific in a group of breast cancer. Thus, correlation of an inheritable fragile site and a malignant disease with familial incidence seems possible.
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000235:genetics*; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged
D005819:Genetic Markers