title: Possible involvement of lumichrome in the binding of storage protein to its receptor in Sarcophaga peregrina.
abstract: Previously, a receptor molecule on the surface of fat body cells of Sarcophaga peregrina larvae that is involved in the uptake of storage protein from the hemolymph was shown to be a 120-kDa protein (Ueno, K., and Natori, S. (1984) J. Biol. Chem. 259, 12107-12111). This paper reports evidence that lumichrome (7,8-dimethylalloxazine) may be present in the binding site of the receptor and mediate the binding of storage protein and receptor. A stoichiometric amount of lumichrome was shown to bind to the storage protein under conditions in which the latter bound to its receptor.
mesh_terms: D000818:Animals; D004175:Diptera / Q000254:growth & development / Q000378:metabolism*; D005216:Fat Body / Q000378:metabolism; D005415:Flavins / Q000378:metabolism* / Q000494:pharmacology; D007301:Insect Hormones / Q000378:metabolism*; D019476:Insect Proteins; D007814:Larva; D011485:Protein Binding / Q000187:drug effects; D011687:Purines / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D005415:Flavins; D007301:Insect Hormones; D019476:Insect Proteins; D011687:Purines; D011956:Receptors, Cell Surface; C043053:storage protein receptor, Saecophaga; C041137:storage proteins, Insecta; C001559:7,8-dimethylalloxazine