Arachidonic acid metabolism by lipoxygenase pathways in uterine and intrauterine tissues of pregnant sheep.
The formation of arachidonate lipoxygenase products by uterine and intrauterine tissues of sheep in the last third of gestation has been evaluated. Maternal and fetal cotyledon, myometrium and fetal membrane exhibited evidence of arachidonate 5-, 12-, and 15- lipoxygenase activities. The major lipoxygenase product formed by fetal membrane and fetal cotyledon was leukotriene B4 (LTB4) whereas maternal cotyledon and myometrium produced mainly 12-hydroxyeicosatetraenoic acid (12-HETE). Arachidonate lipoxygenase products may play significant roles in the regulation of fetal and uteroplacental hemodynamics and it is speculated that the formation of leukotriene B4 predominantly by tissues of fetal origin may be of significance in the immunologic adaptations of pregnancy.
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D000818:Animals; D001091:Arachidonate Lipoxygenases / Q000378:metabolism; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005321:Extraembryonic Membranes / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005260:Female; D006893:Hydroxyeicosatetraenoic Acids / Q000378:metabolism; D007975:Leukotriene B4 / Q000378:metabolism; D009215:Myometrium / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D012756:Sheep
D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D006893:Hydroxyeicosatetraenoic Acids; D007975:Leukotriene B4; D016718:Arachidonic Acid; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; C025984:15-hydroxy-5,8,11,13-eicosatetraenoic acid; D001091:Arachidonate Lipoxygenases