Decreased striatal opiate delta-receptors in the rat model of persistent dyskinesia induced by iminodipropionitrile.
Chronic administration of iminodipropionitrile (IDPN) causes a persistent behavioral syndrome which consists of hyperactivity, vertical neck dyskinesias and lateral head twitches. D-Ala-D-Leu-enkephalin binding revealed a 26% decrease in the number but no change in the affinity of delta-opiate receptors in the striata of IDPN-treated rats. These findings are similar to those seen in the brains of patients with Huntington's disease. Further studies are needed to clarify the relationship of these findings to the phenomenology of the IDPN-induced dyskinetic abnormalities.
D000818:Animals; D003342:Corpus Striatum / Q000032:analysis* / Q000187:drug effects; D004409:Dyskinesia, Drug-Induced / Q000378:metabolism*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000378:metabolism; D016308:Enkephalin, Leucine-2-Alanine; D008297:Male; D009570:Nitriles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000032:analysis* / Q000187:drug effects / Q000378:metabolism; D017465:Receptors, Opioid, delta
D009570:Nitriles; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; C008110:3,3'-iminodipropionitrile; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine