Use of the caprinised strain of rinderpest virus for potency testing an attenuated cell culture rinderpest vaccine.
The caprinised strain of rinderpest virus was inoculated into goats to produce a challenge stock. These goats were kept with control animals (goats, sheep, calves). In this trial the caprinised strain was shown to have a mild pathogenicity for goats and it spread to one of two contact goats but not from goats to other species. The caprinised strain was then tested on cattle where a febrile reaction was observed. The caprinised strain also did not spread between cattle. The cattle vaccinated with a freeze-dried vaccine produced from the attenuated Kabete RBKO strain on bovine kidney cells were then challenged with the caprinised strain with good results.
D000818:Animals; D002417:Cattle; D002986:Clinical Trials as Topic / Q000662:veterinary; D005334:Fever / Q000209:etiology / Q000662:veterinary; D006041:Goats; D012301:Rinderpest / Q000517:prevention & control* / Q000635:transmission; D012302:Rinderpest virus / Q000145:classification / Q000472:pathogenicity*; D012756:Sheep; D013045:Species Specificity; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology
D014613:Vaccines, Attenuated; D014765:Viral Vaccines