Recurrent dedifferentiated liposarcoma of the spermatic cord simulating malignant fibrous histiocytoma: an immunohistochemical and ultrastructural study.
A case of recurrent dedifferentiated liposarcoma simulating malignant fibrous histiocytoma, with complete absence of lipoblastic differentiation, is described. The tumour cells showed strongly positive immunostaining for alpha-1-antichymotrypsin. Electron microscopy revealed a mixture of fibroblasts and histiocytes. Our findings suggest that the dedifferentiated component reflects an altered differentiation pathway of the primitive mesenchymal cells in the original liposarcoma.
D000368:Aged; D002454:Cell Differentiation; D003937:Diagnosis, Differential; D005834:Genital Neoplasms, Male / Q000473:pathology* / Q000648:ultrastructure; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D008080:Liposarcoma / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009364:Neoplasm Recurrence, Local; D013085:Spermatic Cord