title: Prostaglandin vaginal suppositories in non pregnant women requiring cervical dilatation prior to hysteroscopy.
abstract: A randomized doubleblind investigation of prostaglandin vaginal suppositories prior to hysteroscopy was undertaken in 30 non-pregnant women. PGE2 in 14 of 15 treated patients we found a softening and a dilatation of the cervical canal, but with a relatively high frequency of side effects-nausea, vomiting and diarrhea. No serious bleeding or side effects were observed.
mesh_terms: D015064:16,16-Dimethylprostaglandin E2 / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives; D002584:Cervix Uteri / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004106:Dilatation / Q000379:methods*; D004311:Double-Blind Method; D004724:Endoscopy; D005260:Female; D006801:Humans; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage*; D011897:Random Allocation; D013488:Suppositories; D014599:Uterus; D014621:Vagina
chemical_list: D011459:Prostaglandins E, Synthetic; D013488:Suppositories; C025505:meteneprost; D015064:16,16-Dimethylprostaglandin E2