[The role of vasopressin and oxytocin in the regulation of glycemia levels and carbohydrate metabolism in the liver].
Vasopressin and oxytocin administered subcutaneously and intravenously in a dose of 0.5 IU/kg were studied in experiments on albino male rats for their effect on the glycogen content and gluconeogenesis enzymes activity in the liver as well as on the glycemia level. Neurohormones injected subcutaneously have no effect on the values of the measured indices. Vasopressin already the first 15-60 min after its intravenous injection in the mentioned dose leads to an essential decrease of the glucose content in blood, glycogen amount, glucose-6-phosphatase and fructose-1.6-diphosphatase (EC 3.1.3.9 and 3.1.3.11) activity in the liver of test animals. The intravenous injection of oxytocin in the same dose induces changes in the carbohydrate metabolism indices similar in their direction and magnitude to the effects of intravenous injection of vasopressin.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D006597:Fructose-Bisphosphatase / Q000378:metabolism; D005943:Gluconeogenesis; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D010121:Oxytocin / Q000494:pharmacology*; D051381:Rats; D014667:Vasopressins / Q000494:pharmacology*
D001786:Blood Glucose; D008112:Liver Glycogen; D014667:Vasopressins; D010121:Oxytocin; D006597:Fructose-Bisphosphatase; D005952:Glucose-6-Phosphatase
Uchastie vazopressina i oksitotsina v reguliatsii urovnia glikemii i obmena uglevodov v pecheni.