[Action of imipenem on Enterobacter cloacae].
Most of Enterobacter cloacae strains produce chromosomally determined class I beta-lactamases when they are exposed to beta-lactams. Imipenem is a strong inducer of these enzymes but is poorly affected by them. We compared the effect of imipenem on inducible, non-inducible and stably derepressed strains of E. cloacae using the killing curve system. With antibiotic concentrations of 0.5 mg/l or more, an intense dose-dependent bactericidal effect was observed within 4 to 6 hours. However the bactericidal activity was incomplete. With an inoculum as low as 10(5) bacteria/ml a regrowth was observed after 24 hours. Among the surviving bacteria imipenem had the same bactericidal kinetic than on the parental strain. Similar results were observed with inducible, non-inducible and stably derepressed strains.
D002439:Cefotaxime / Q000494:pharmacology; D002440:Cefoxitin / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D004754:Enterobacter / Q000187:drug effects* / Q000235:genetics; D004755:Enterobacteriaceae / Q000187:drug effects*; D015378:Imipenem; D009070:Moxalactam / Q000494:pharmacology; D010403:Penicillin Resistance; D010641:Phenotype; D010878:Piperacillin / Q000494:pharmacology; D013845:Thienamycins / Q000008:administration & dosage / Q000494:pharmacology*
D013845:Thienamycins; D002440:Cefoxitin; D015378:Imipenem; D002442:Ceftazidime; D002439:Cefotaxime; D009070:Moxalactam; D010878:Piperacillin
Etude de l'action de l'imipénème sur Enterobacter cloacae.