[Prevention of hepatic metastases in rabbits by administration of an oily anticancer agent into the portal vein].
We studied one kind of prophylactic chemotherapy against hepatic metastases. The therapy was carried out with a lymphographic oily contrast medium. Lipiodol, and a high-molecular-weight anticancer agent known as SMANCS. SMANCS was dissolved in Lipiodol by sonication (SMANCS/Lipiodol, 1 mg of SMANCS in 1 ml of Lipiodol). SMANCS/Lipiodol, administered into the portal vein, remained for a long time in the portal vein and was eliminated gradually through the bile and urine. SMANCS/Lipiodol (0.4ml/kg) was injected into the mesenteric vein in rabbits, which were then inoculated with the highly malignant carcinoma VX-2. Rabbits injected with SMANCS/Lipiodol before inoculation had significantly fewer hepatic metastases than the control 12 days later (P less than 0.001). Survival was significantly longer (P less than 0.005; 36.0 +/- 7.7 days) with SMANCS/Lipiodol before inoculation than without treatment (23.5 +/- 3.0 days). Hepatic metastases might thus be prevented by portal administration of an appropriate oily anticancer agent.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D005663:Furans / Q000008:administration & dosage*; D007275:Injections, Intravenous; D007459:Iodized Oil / Q000008:administration & dosage*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology / Q000517:prevention & control* / Q000556:secondary; D008299:Maleic Anhydrides / Q000008:administration & dosage*; D011137:Polystyrenes / Q000008:administration & dosage*; D011169:Portal Vein / Q000000981:diagnostic imaging; D011817:Rabbits; D011859:Radiography; D009353:Zinostatin / Q000008:administration & dosage* / Q000031:analogs & derivatives
D000903:Antibiotics, Antineoplastic; D005663:Furans; D008299:Maleic Anhydrides; D011137:Polystyrenes; C035755:poly(maleic acid-styrene)neocarzinostatin; D007459:Iodized Oil; D009353:Zinostatin