Ca2+ metabolism in arteries of spontaneously hypertensive rats: assessment by proton-induced X-ray emission.
Changes of intracellular Ca2+-metabolism have been considered to be of importance for the pathogenesis of essential hypertension. In the present study particle-induced X-ray emission (PIXE) was used to get information on the spatial distribution of Ca2+ in aortas and renal arteries of spontaneously hypertensive (SHR) and normotensive rats. Our findings demonstrate a significant Ca2+ elevation in the aorta and renal artery of SHR versus normotensive Wistar-Kyoto (WKY) rats (3317 +/- 734 micrograms Ca2+/g tissue versus 1623 +/- 569 micrograms Ca2+/g tissue and 3432 +/- 1867 micrograms Ca2+/g tissue versus 1050 +/- 554 micrograms Ca2+/g tissue).
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D011522:Protons; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013052:Spectrometry, X-Ray Emission
D011522:Protons; D002118:Calcium