Immunohistochemical staining of cells in the brain of a patient with acquired immune deficiency syndrome (AIDS) with a monoclonal antibody to visna virus.
Several monoclonal antibodies to different epitopes of the two major core proteins of visna virus, p25 and p15, were tested with the Avidin-Biotin immunostaining method on formaldehyde-fixed and paraffin-embedded sections of brains from patients with acquired immune deficiency syndrome (AIDS) who had shown neurological symptoms at death. In one of five AIDS cases a few cells, mainly inflammatory cells, showed a positive staining with a monoclonal antibody to the p25 core protein of visna.
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology*; D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D001921:Brain / Q000382:microbiology*; D006801:Humans; D007120:Immunochemistry; D014790:Visna-maedi virus / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral