Thorotrast-associated hepatic leiomyosarcoma and cholangiocarcinoma in a single patient.
A 66-year-old man developed two distinct primary malignant hepatic neoplasms (leiomyosarcoma and cholangiocarcinoma) 50 years after Thorotrast administration. This is the first case report of Thorotrast-associated primary hepatic leiomyosarcoma. Ultrastructural and immunohistochemical studies are discussed.
D002759:Adenoma, Bile Duct / Q000139:chemically induced* / Q000473:pathology / Q000648:ultrastructure; D000368:Aged; D001650:Bile Duct Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007890:Leiomyosarcoma / Q000139:chemically induced* / Q000473:pathology / Q000648:ultrastructure; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced* / Q000473:pathology / Q000648:ultrastructure; D013911:Thorium Dioxide / Q000009:adverse effects*
D013911:Thorium Dioxide