[The role of heparin in the realization of the effect of various protein hormones].
In immature female rats the ovarian mass increased by 74.3% 48 h after the administration of 50 units of LH. The stimulating LH effect on the ovary did not show itself against a background of the binding of circulatory heparin by multiple administration of protamine-sulphate (P-S) for 3 days. The blockade could be abolished by compensatory administration of heparin (twice at a dose of 50 units/100 g. Likewise, the stimulating ACTH effect on corticosterone secretion in adult male rats did not show itself in P-S-heparin binding. If in the blockade of discharge of the animal own ACTH by dexamethasone 2.5 units of exogenous ACTH resulted in an increase in corticosterone concentration from 9 to 16.2 Mg% in 15 min, in P-S single administration 5-10 min before ACTH, corticosterone concentration remained practically at the basal level. Heparin injection within the interval between P-S and ACTH administration ensured the manifestation of the stimulating ACTH effect, and blood corticosterone concentration increased in the same degree as in the administration of ACTH only. Thus, it can be assumed that the presence of reactive heparin in the blood is necessary for the implementation of action of some protein hormones.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D005260:Female; D006493:Heparin / Q000097:blood* / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D010053:Ovary / Q000502:physiology; D011479:Protamines / Q000378:metabolism; D051381:Rats
D011479:Protamines; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D006493:Heparin
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