Hepatocellular carcinoma in Chinese males and females. Possible causes for the male predominance.
The male-female ratio in 186 hepatocellular carcinoma (HCC) Chinese patients was 5:1. The clinical presentation, biochemical parameters, and histologic findings were the same in both sexes except for a higher proportion of underlying cirrhosis (P = 0.02), and spider naevi (P = 0.04) in the men. There were also more smokers and alcohol drinkers among the men. Over 75% of both sexes were positive for the hepatitis B surface antigen. The possible contributory factors to the predominance of males to females in HCC included: the association with the hepatitis B virus, the higher proportion of male cirrhotics, smoking, and alcohol drinking. The survival probability for both sexes was equally poor; the median survival was 8 weeks for males and 10 weeks for females.
D000206:Actuarial Analysis; D000428:Alcohol Drinking; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D002681:China / Q000208:ethnology; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006723:Hong Kong; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D012907:Smoking
D006514:Hepatitis B Surface Antigens