Inhibition of rat brain cytochrome oxidase activity by pyrolysed products of methyl isocyanate.
The effects were studied of methyl isocyanate (MIC) and its thermally degraded products (dMIC) on rat brain cytochrome oxidase activity. Pure MIC did not inhibit brain cytochrome oxidase activity. A significant inhibition of brain cytochrome oxidase activity by dMIC was observed both in vivo and in vitro. The presence of cyanide in pyrolysed products of MIC has also been confirmed by chemical methods.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D003485:Cyanates / Q000633:toxicity*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D005260:Female; D007274:Injections, Intraperitoneal; D017953:Isocyanates; D051381:Rats
D003485:Cyanates; D017953:Isocyanates; C008461:methyl isocyanate; D003576:Electron Transport Complex IV