Structure-activity relationship of novel oligopeptide antiviral and antitumor agents related to netropsin and distamycin.
A group of oligopeptides have been synthesized that are structurally related to the natural antiviral antitumor agents netropsin and distamycin. Cytostatic activity against both human and murine tumor cell lines as well as their in vitro activity against a range of viruses is reported. The biological activity of these agents is discussed both in terms of their structural differences and, in particular, in relation to their observed base- and sequence-dependent minor-groove binding to duplex oligonucleotides.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D002460:Cell Line; D004214:Distamycins / Q000138:chemical synthesis*; D004353:Drug Evaluation, Preclinical; D006146:Guanidines / Q000138:chemical synthesis*; D006801:Humans; D007202:Indicators and Reagents; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D009429:Netropsin / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D011758:Pyrroles / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship; D014616:Vaccinia virus / Q000187:drug effects
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004214:Distamycins; D006146:Guanidines; D007202:Indicators and Reagents; D009842:Oligopeptides; D011758:Pyrroles; D009429:Netropsin