Intracellular sodium concentration in lymphocytes and erythrocytes of patients with essential hypertension.
In order to investigate the abnormalities in intracellular sodium concentration ([Na]i) in essential hypertension, [Na]i in lymphocytes and erythrocytes was determined in 37 outpatients with essential hypertension and 35 normotensive controls matched for sex and age. [Na]i in lymphocytes was higher in hypertensive patients than in normotensive controls, while no difference was observed in [Na]i in erythrocytes between the 2 groups. There was no significant correlation between [Na]i in lymphocytes and erythrocytes in either group. In hypertensive patients, plasma renin activity had a negative correlation with [Na]i in lymphocytes, but not with [Na]i in erythrocytes. These results suggest that the increase in [Na]i may be associated with essential hypertension with suppressed plasma renin activity and that lymphocytes are more suitable than erythrocytes for the analysis of [Na]i.
D004912:Erythrocytes / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism*
D012964:Sodium; D012083:Renin