title: The effect of hypophysectomy, ACTH fragments and thalamic lesions upon kindled epilepsy.
abstract: Hypophysectomized rats showed aberrant and retarded rates of kindled epilepsy. In hypophysectomized rats administered adrenocorticotropic hormone (ACTH) subunits ACTH4-10 and ACTH1-24, the normal kindling pattern was restored. However, in hypophysectomized animals which also had lesions of the thalamus (nucleus parafascicularis), ACTH4-10 did not restore the normal pattern of kindling. There have been many conjectures that kindling may be a subcase of learning. These results are compatible with this hypothesis, since the same procedures act in an analogous fashion within avoidance conditioning paradigms.
mesh_terms: D000311:Adrenal Glands / Q000473:pathology / Q000503:physiopathology; D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D003366:Cosyntropin / Q000494:pharmacology*; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology*; D007016:Hypophysectomy; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D009929:Organ Size; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013788:Thalamus / Q000473:pathology / Q000503:physiopathology*
chemical_list: D010446:Peptide Fragments; D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10)