Vascularity and cytochrome oxidase distribution in the occipital cortex in MAM Ac-induced micrencephaly.
The laminar distributions of cytochrome oxidase activity and vascularization of the occipital cortex of animals made micrencephalic by exposure to MAM Ac on E14 or E16 were examined and compared to control animals. Despite severe disruptions of the normal cytoarchitecture in MAM Ac exposed animals, the laminar distributions of vascular profiles, branch points and cytochrome oxidase activity in micrencephalic animals were similar to those in control animals.
D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects / Q000201:enzymology; D003576:Electron Transport Complex IV / Q000378:metabolism*; D005260:Female; D006651:Histocytochemistry; D008746:Methylazoxymethanol Acetate / Q000633:toxicity*; D008831:Microcephaly / Q000139:chemically induced* / Q000201:enzymology; D009778:Occipital Lobe / Q000098:blood supply* / Q000187:drug effects / Q000201:enzymology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D001391:Azo Compounds; D008746:Methylazoxymethanol Acetate; D003576:Electron Transport Complex IV