Comparative analysis of the canAV-1 and canAV-2 genomes.
The molecular weights of canine adenovirus type 1 (canAV-1, strain Utrecht) and type 2 (canAV-2, strain Toronto A26/61) DNAs were determined by contour length measurements and restriction endonuclease analysis. In each case, an average molecular weight value of 20 (+/- 0.5) X 10(6) daltons was obtained with both methods. Similar in size, the canAV-1 and canAV-2 DNA molecules were, however, cleaved at very distinct positions by a variety of restriction endonucleases. The observed lack of DNA sequence homology confirms the existence of at least two different canine adenovirus species [Intervirology 23: 23-28 (1985)].
D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D002460:Cell Line; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000032:analysis* / Q000648:ultrastructure; D004285:Dogs; D004587:Electrophoresis, Agar Gel; D005814:Genes, Viral; D008854:Microscopy, Electron; D008970:Molecular Weight; D012689:Sequence Homology, Nucleic Acid
D004279:DNA, Viral; D004262:DNA Restriction Enzymes