[Secondary-reinforcing effects of opiate agonists in the mouse].
Comparative examination of secondary-reinforcing properties of opiate agonists morphine, nalorphine, pentazocine and phencyclidine was carried out on mice using procedure of place preference conditioning in an automatic shuttle-box. Morphine, phencyclidine and pentaxocine (but not nalorphine) produced strong dose-dependent secondary-reinforcing effects. Special features of behavioural manifestations of their secondary-reinforcing action were analyzed in aspect of changes in temporal asymmetry and attendant locomotor activity of animals in the shuttle-box. On the basis of the obtained and literature data, it is suggested that mu- and sigma-opiate receptors mediate secondary-reinforcing effects of opiate agonists.
D000818:Animals; D003214:Conditioning, Classical; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D009269:Nalorphine / Q000494:pharmacology; D009294:Narcotics / Q000494:pharmacology*; D010423:Pentazocine / Q000494:pharmacology; D010622:Phencyclidine / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects*; D012054:Reinforcement, Psychology
D009294:Narcotics; D011957:Receptors, Opioid; D009020:Morphine; D010622:Phencyclidine; D010423:Pentazocine; D009269:Nalorphine
Vtorichno-podkrepliaiushchie éffekty opiatnykh agonistov u mysheĭ.