title: Treatment of postcesarean endomyometritis.
abstract: Improved understanding of the microbiology of postcesarean endometritis has dramatically changed the approach to its antibiotic therapy. Initial therapy should include broad-spectrum anaerobic coverage, including against all Bacteroides species, as well as gram-positive and gram-negative aerobic coverage. Moreover, ideally initial therapy should also include coverage of Chlamydia trachomatis. Furthermore, although the use of antibiotic prophylaxis for high-risk patients undergoing cesarean section has significantly decreased their incidence of febrile morbidity, one must remember that prophylactic antibiotics have important bacteriologic effects that may limit the efficacy of monotherapy for the treatment of endometritis in prophylaxis failures.
mesh_terms: D002585:Cesarean Section / Q000009:adverse effects*; D002981:Clindamycin / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004716:Endometritis / Q000188:drug therapy* / Q000191:economics / Q000209:etiology; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects; D006089:Gram-Negative Anaerobic Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D011247:Pregnancy; D011645:Puerperal Infection / Q000188:drug therapy* / Q000191:economics
chemical_list: D004338:Drug Combinations; D005839:Gentamicins; D002981:Clindamycin