title: Characterization of somatically acquired ecotropic and mink cell focus-forming viruses in lymphomas of AKXD recombinant inbred mice.
abstract: The DNA of lymphomas from 12 AKXD recombinant inbred mouse strains was analyzed to determine the presence of somatically acquired ecotropic and mink cell focus-forming proviruses. Mink cell focus-forming proviruses were associated primarily with T-cell lymphomas, whereas ecotropic proviruses were associated with lymphomas of B-cell and myeloid lineages. A model based on the results is proposed to explain the variation in lymphoma types observed in different AKXD strains.
mesh_terms: D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D004279:DNA, Viral / Q000032:analysis; D009052:Leukemia Virus, Murine / Q000235:genetics / Q000302:isolation & purification*; D008223:Lymphoma / Q000382:microbiology*; D051379:Mice; D008811:Mice, Inbred DBA; D008908:Mink Cell Focus-Inducing Viruses / Q000235:genetics / Q000302:isolation & purification*; D011519:Proto-Oncogenes; D011995:Recombination, Genetic; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004279:DNA, Viral