Trisomy 18 and hepatic neoplasia.
A 2 9/12-year-old girl with trisomy 18 presented with a 3-week history of low grade fever, abdominal distention, and hepatosplenomegaly. Abdominal cytotomography (CT) scan showed hepatic infiltration with a tumor mass presumed to be hepatoblastoma. She deteriorated rapidly and died 3 weeks later. No autopsy and/or biopsy could be done.
D000015:Abnormalities, Multiple / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics; D002675:Child, Preschool; D002887:Chromosomes, Human, Pair 18; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000235:genetics*; D014314:Trisomy