The effect of chronic captopril therapy on platelet angiotensin II receptor density and vascular responsiveness to angiotensin II infusion.
The density of angiotensin II (Ang II) receptors on the platelet and the vascular responsiveness to infused angiotensin II before and after two weeks of captopril therapy were examined in ten healthy male volunteers. There was a significant increase in blood flow to the forearm, but no significant changes in either the density of angiotensin II receptors or the pressor response to infused angiotensin II following captopril therapy. The study demonstrates that long term reduction of angiotensin II formation by captopril in man does not increase the responsiveness of the receptors to infused angiotensin, nor results in an "up regulation" of the angiotensin receptors. It also provides further evidence that some of the long term vasodilator effects of captopril may be mediated by mechanisms other than inhibition of angiotensin I (Ang I) converting enzyme.
D000293:Adolescent; D000328:Adult; D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology*; D005542:Forearm / Q000098:blood supply; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011945:Receptors, Angiotensin / Q000032:analysis* / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D012083:Renin / Q000097:blood; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects*
D000806:Angiotensin-Converting Enzyme Inhibitors; D011945:Receptors, Angiotensin; D000804:Angiotensin II; D002216:Captopril; D007703:Peptidyl-Dipeptidase A; D012083:Renin