title: Replication of infectious bursal disease virus in continuous cell lines.
abstract: Three mammalian continuous cell lines--MA-104, Vero, and BGM-70--were tested for their ability to support replication of infectious bursal disease virus (IBDV). Selected tissue-culture-adapted vaccine strains and tissue-culture-adapted field isolates of IBDV replicated in the MA-104, Vero, and BGM-70 cells; cytopathic effects were most pronounced in the BGM-70 cells. The cytopathic effects of the viruses in BGM-70 cells and chicken embryo fibroblast (CEF) cultures were similar. Virus-neutralization titers of selected serum samples determined in BGM-70 cultures compared well with those obtained from CEF cultures.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D005347:Fibroblasts; D007243:Infectious bursal disease virus / Q000254:growth & development / Q000276:immunology / Q000502:physiology*; D009500:Neutralization Tests; D012087:Reoviridae / Q000502:physiology*; D014709:Vero Cells; D014779:Virus Replication
chemical_list: D000914:Antibodies, Viral