[Anti-arrhythmic action of adenosine and the cyclic nucleotide content of the myocardium of rats with ischemia].
In anesthetized rats a 30-min intravenous infusion of adenosine (2.5 mg/kg/min) performed after the coronary artery ligation significantly decreased the incidence and severity of early ischemic arrhythmias. After the infusion of adenosine, there was an increase in cGMP level in the left ventricular myocardium, cAMP content remained unchanged.
D000241:Adenosine / Q000627:therapeutic use*; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D000242:Cyclic AMP; D006152:Cyclic GMP; D000241:Adenosine
Antiaritmicheskoe deĭstvie adenozina i soderzhanie tsiklicheskikh nukleotidov v miokarde krys pri ishemii.