[The role of the adenylate cyclase system in the inhibition of gastric secretion by products of limited hydrolysis of kappa-casein].
The influence of the peptide inhibiting gastric acid secretion and derived from kappa-casein on the levels of cAMP, cGMP and adenylate cyclase activity of rat gastric mucosa was studied. Intravenous peptide preparation administration failed to alter cyclic nucleotide levels. The revealed decrease of adenylate cyclase activity was due to the presence of calcium in the investigated peptide preparation. It was assumed that cyclase system of the rat gastric mucosa cells were not involved in the inhibition of gastric acid secretion by the peptide preparations under study.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002364:Caseins; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D003864:Depression, Chemical; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D011492:Protein Hydrolysates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002364:Caseins; D011492:Protein Hydrolysates; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D006152:Cyclic GMP
Rol' adenilattsiklaznoĭ sistemy v tormozhenii zheludochnoĭ sekretsii produktami ogranichennogo proteoliza kappa-kazeina.