[Synthesis of leukotriene A4 methyl ester via acetylene intermediates].
Rac-leukotriene A4 methyl ester has been synthesized from propargylic alcohol and 1-heptyne. The synthetic strategy involves the assembly of carbon chain by acetylenide anion condensations and the introduction of (Z)-double bonds by the triple bond hydrogenation.
D000114:Acetylene; D001095:Arachidonic Acids / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004952:Esters; D017572:Leukotriene A4
D001095:Arachidonic Acids; D004952:Esters; D017572:Leukotriene A4; D000114:Acetylene
Sintez metilovogo éfira leĭkotriena A4 na osnove atsetilenovykh soedineniĭ.