Dieting and weight loss in volunteers increases the number of alpha 2-adrenoceptors and 5-HT receptors on blood platelets without effect on [3H]imipramine binding.
Platelet monoamine receptor binding was determined in normal male and female subjects before and at the end of a 2- to 3-week weight reducing diet (1200 kcal daily). Dieting was associated with an increase in platelet binding sites for both [3H]yohimbine and [125I]iodolysergic acid diethylamide (iodoLSD). The affinity at the platelet [125I]iodoLSD binding site was reduced. In contrast, [3H]imipramine binding was unchanged. These results have important implications for studies that employ platelet binding as a peripheral marker of neurotransmitter function in psychiatric illness.
D000328:Adult; D001665:Binding Sites; D001792:Blood Platelets / Q000378:metabolism*; D001835:Body Weight; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood*; D008238:Lysergic Acid Diethylamide / Q000097:blood; D008297:Male; D008875:Middle Aged; D011942:Receptors, Adrenergic, alpha / Q000032:analysis*; D011985:Receptors, Serotonin / Q000032:analysis*; D012737:Sex Factors; D015016:Yohimbine / Q000097:blood
D011942:Receptors, Adrenergic, alpha; D011985:Receptors, Serotonin; D015016:Yohimbine; D008238:Lysergic Acid Diethylamide; D007099:Imipramine