The prostacyclin/thromboxane balance is favourably shifted in Greenland Eskimos.
The rare incidence of cardiovascular disease in Eskimos has been ascribed to their diet rich in eicosapentaenoic acid (EPA, C20:5n-3) and hence a possible formation of trienoic prostanoids. In this study we compare endogenous formation of prostacyclin (PGI), which is formed by the endothelial cell, and thromboxane (TXA), which is formed by platelets in 20 Eskimos and 20 age and sex matched Danish controls by measurement of the main urinary metabolites. Considerable formation of bioactive PGI3 from dietary EPA was shown in Eskimos, which was barely detectable in the controls. Furthermore synthesis of PGI2 was significantly higher in Eskimos in spite of a markedly lower arachidonate content in membrane lipids. In contrast formation of TXA2,3 was lower in Eskimos as compared to the Danish controls. We conclude, that the balance between PGI and TXA, which may regulate the interaction of platelet and vessel wall, is favourably shifted in Greenland Eskimos to an antithrombotic state.
D000328:Adult; D044466:Asian People; D004041:Dietary Fats / Q000494:pharmacology; D015118:Eicosapentaenoic Acid / Q000494:pharmacology; D011464:Epoprostenol / Q000378:metabolism* / Q000652:urine / Q000031:analogs & derivatives; D005260:Female; D006116:Greenland; D006801:Humans; D008297:Male; D008875:Middle Aged; D013929:Thromboxane B2 / Q000031:analogs & derivatives / Q000652:urine; D013931:Thromboxanes / Q000378:metabolism*
D004041:Dietary Fats; D013931:Thromboxanes; D013929:Thromboxane B2; C034240:prostaglandin I3; D015118:Eicosapentaenoic Acid; D011464:Epoprostenol; C039158:thromboxane B3