Suppression of streptococcal cell wall-induced arthritis by a potent protease inhibitor, bis(5-amidino-2-benzimidazolyl)methane.
Bis(5-amidino-2-benzimidazolyl)methane, a powerful synthetic trypsin inhibitor, proved to be highly effective in suppressing the arthritis induced by streptococcal cell wall fragments in Lewis rats. It reduced not only the degree of synovitis, osteitis, and hematopoietic hyperplasia in the distal extremities, but also the degree of associated granulomatous inflammation in the liver. The results suggest that trypsin-like proteases play an important role in this arthritis model and that inhibitors may be useful in the treatment of similar arthritic conditions in humans.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001168:Arthritis / Q000517:prevention & control*; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D001562:Benzimidazoles / Q000494:pharmacology*; D002473:Cell Wall / Q000502:physiology; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000517:prevention & control; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D007249:Inflammation / Q000517:prevention & control; D007596:Joints / Q000187:drug effects / Q000473:pathology; D010457:Peptidoglycan / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000473:pathology; D013297:Streptococcus pyogenes / Q000502:physiology* / Q000648:ultrastructure
D000893:Anti-Inflammatory Agents; D001562:Benzimidazoles; D010457:Peptidoglycan; C025426:bis(5-amidino-2-benzimidazolyl)methane