[Features and mechanisms of the effect of adrenaline and noradrenaline on the pumping function of the heart during hypokinesia].
The effect of epinephrine (E) and norepinephrine (NE) on cardiac output (CO) and heart rate (HR) of hypokinetic and control rats was studied. It was found that in the hypokinetic animals the E effect on CO was significantly weaker than in the controls while the NE effect was stronger. In most experiments the response to NE in the hypokinetic animals was greater than that to E. The mean HR increase was not significantly different in the two groups but in the hypokinetic rats the response to E was less expressed. These data give reason to believe that the lower E effect on CO in the hypokinetic animals is associated with diminished alpha-adrenergic effects on the heart.
D000818:Animals; D004837:Epinephrine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D009068:Movement; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D012149:Restraint, Physical; D013318:Stroke Volume / Q000187:drug effects*
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D009638:Norepinephrine; D004837:Epinephrine
Osobennosti i mekhanizmy vliianiia adrenalina i noradrenalina na nasosnuiu funktsiiu serdtsa pri gipokinezii.