title: Structure and function of the transcriptional control region of nonpassaged BK virus.
abstract: We compared the nucleotide sequence in the transcriptional control region of BK virus isolates cloned directly from human urine (BK-WW) with that of prototype BK virus. BK-WW was found to have a 63-base-pair insertion and only one of the 68-base-pair enhancer repeat elements. In transient expression assays, BK-WW enhancer showed approximately one-half the activity given by the prototype enhancer.
mesh_terms: D001739:BK Virus / Q000235:genetics*; D001483:Base Sequence; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D005809:Genes, Regulator; D005814:Genes, Viral; D011120:Polyomavirus / Q000235:genetics*; D013045:Species Specificity; D014158:Transcription, Genetic