Diminished release of lactoferrin from polymorphonuclear leukocytes of human neonates.
In neonatal and adult polymorphonuclear leukocytes (PMN) we determined the content and the release of beta-glucuronidase, myeloperoxidase, lysozyme and lactoferrin. We found an equal total content of these proteins in adult and neonatal PMN, except for a lower lysozyme concentration in neonatal PMN. In the presence of opsonized zymosan myeloperoxidase, lysozyme and beta-glucuronidase were released in equal amounts; lactoferrin, however, was released to a lower rate from neonatal than from adult PMN (p less than 0.0005).
D000328:Adult; D000375:Aging / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000378:metabolism; D005312:Fetal Blood / Q000166:cytology; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007781:Lactoferrin / Q000097:blood*; D007782:Lactoglobulins / Q000097:blood*; D009113:Muramidase / Q000378:metabolism; D009504:Neutrophils / Q000201:enzymology / Q000378:metabolism*; D009195:Peroxidase / Q000378:metabolism
D007782:Lactoglobulins; D009195:Peroxidase; D009113:Muramidase; D005966:Glucuronidase; D007781:Lactoferrin