Activity of nedocromil sodium in mast-cell-dependent reactions in the rat.
Nedocromil sodium, a pyranoquinoline dicarboxylic acid derivative which differs structurally and physiochemically from sodium cromoglycate, was nonetheless shown to be effective in classical models of anti-allergic activity in the rat. These models, based on immediate hypersensitivity reactions in the passively sensitized rat, involve release of mediators from mast cells following cross-linking of membrane-bound IgE antibodies by specific antigen. In this system, nedocromil sodium exhibited a similar profile of activity to that of sodium cromoglycate. Whilst not predictive for therapeutic activity, rat models of immediate hypersensitivity are believed to reflect one component of obstructive airways disease. The results suggest that nedocromil sodium is worthy of clinical evaluation in this indication.
D000818:Animals; D001986:Bronchial Spasm / Q000188:drug therapy; D004205:Cromolyn Sodium / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008407:Mast Cells / Q000276:immunology*; D017835:Nedocromil; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats
D011804:Quinolines; D017835:Nedocromil; D004205:Cromolyn Sodium