Regional distribution of the phenylalanine-sensitive ATP-sulphurylase in brain.
The regional distribution of the phenylalanine-sensitive ATP-sulphurylase in fetal calf brain coincides with demyelinated lesions observed in the central nervous systems of untreated PKU patients. This would be expected if this species of ATP-sulphurylase played a role in the pathogenesis of brain dysfunction in the untreated or poorly controlled phenylketonuria patient.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002417:Cattle; D003711:Demyelinating Diseases / Q000201:enzymology; D009713:Nucleotidyltransferases / Q000032:analysis*; D010649:Phenylalanine / Q000494:pharmacology*; D013430:Sulfate Adenylyltransferase / Q000032:analysis* / Q000037:antagonists & inhibitors
D010649:Phenylalanine; D009713:Nucleotidyltransferases; D013430:Sulfate Adenylyltransferase