Lithium suppresses seizure susceptibility in pentylenetetrazol-kindled rats.
With regard to the still debatable effect of lithium in epilepsy the effect of chronic lithium treatment on the development of pentylenetetrazol(PTZ)-kindling and the anti-convulsive potency of acute lithium administration on PTZ-induced seizure behaviour in PTZ-kindled and non-kindled rats was examined. Lithium significantly suppressed the development of PTZ-kindling. In kindled rats the acute application of lithium reduced seizure susceptibility in a dose-dependent manner. In contrast to kindled rats, in non-kindled animals lithium had very weak anticonvulsive potency. The results suggest that lithium may be of potential interest in the treatment of special forms of epilepsy and epileptic brain disorders.
D000818:Animals; D002712:Chlorides / Q000627:therapeutic use*; D004198:Disease Susceptibility; D005260:Female; D007696:Kindling, Neurologic / Q000187:drug effects; D008094:Lithium / Q000627:therapeutic use*; D018021:Lithium Chloride; D010433:Pentylenetetrazole; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*
D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride; D010433:Pentylenetetrazole