[Role of the GABA- and cholinergic systems in the formation of a dissociated state to an antioxidant of the 3-hydroxypyridine class].
The experiments on rats have shown that the elaboration of conditioned drinking reflex in T-maze during administration of 2-ethyl-6-methyl-3-hydroxypyridine antioxidant with an anti-stress effect was accompanied by the development of state dependent learning. However, its formation was slower, as compared to state dependent learning in response to the known psychotropic drugs. The replacing test with the injection of bicuculline, picrotoxin, Ca valproate, Ro-15-1788, benactyzine, Cleregil, etc. during state dependent learning made it possible to establish the role of GABA and cholinergic systems in the formation of state dependent learning and in the development of disorders in emotional behavioural reactions after long-term administration and withdrawal of 3-hydroxypyridine.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects; D004213:Dissociative Disorders / Q000139:chemically induced* / Q000523:psychology; D004644:Emotions / Q000187:drug effects; D007858:Learning / Q000187:drug effects; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011963:Receptors, GABA-A / Q000187:drug effects*; D013997:Time Factors
D000975:Antioxidants; D011619:Psychotropic Drugs; D011725:Pyridines; D011950:Receptors, Cholinergic; D011963:Receptors, GABA-A; C023500:3-hydroxypyridine
Rol' GAMK- i kholinergicheskikh sistem v formirovanii dissotsiirovannogo sostoianiia k antioksidantu iz klassa 3-oksipiridinov.