Effects of ketoconazole and itraconazole on growth and sterol synthesis in Pityrosporum ovale.
The effects of ketoconazole and itraconazole on growth and sterolsynthesis in Pityrosporum ovale was studied. Itraconazole was at least 10 times more active than ketoconazole. Sterol synthesis was inhibited more rapidly than growth, suggesting that the antifungal activity of both azoles originates from an effect on the 14 alpha demethylase system, as seen in other species.
D000935:Antifungal Agents / Q000494:pharmacology*; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008290:Malassezia / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D013261:Sterols / Q000096:biosynthesis*
D000935:Antifungal Agents; D013261:Sterols; D017964:Itraconazole; D007654:Ketoconazole