[Features of the distribution of HLA antigens in patients with neurologic manifestations of lumbar osteochondrosis].
Examinations of the HLA antigens (A and B loci) distribution in patients with neurologic manifestations of lumbar osteochondrosis (NMLO) has revealed a statistically more rare incidence of A11 antigens and a more frequent one, of B7 and B18 ones. A different distribution of the antigens in cases with the major clinical forms of lumbar osteochondrosis was noted. Patients with discogenic lumbosacral radiculitis differed from normal subjects by the same antigens as all NMLO patients. For patients with lumbar ischialgia increased concentrations of B7 and B18 antigens were characteristic, whereas in radicular ischialgias A11 and B15 antigens were less incident and B40 one, more incident. The findings confirm the polygenic nature of hereditary predisposition to NMLO.
D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens; D059870:HLA-A11 Antigen; D015235:HLA-B Antigens; D059911:HLA-B18 Antigen; D015793:HLA-B7 Antigen; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000235:genetics; D008159:Lumbar Vertebrae; D008297:Male; D010007:Osteochondritis / Q000235:genetics* / Q000276:immunology; D010523:Peripheral Nervous System Diseases / Q000235:genetics / Q000276:immunology; D013126:Spinal Nerve Roots
D006680:HLA Antigens; D015234:HLA-A Antigens; D059870:HLA-A11 Antigen; D015235:HLA-B Antigens; D059911:HLA-B18 Antigen; D015793:HLA-B7 Antigen
Osobennosti raspredeleniia antigenov HLA u bol'nykh s nevrologicheskimi proiavleniiami poiasnichnogo osteokhondroza.