The effects of parenteral injections of adenosine and its analogs on blood pressure and heart rate in the rat.
The dose-response effects of adenosine and its analogs on cardiovascular parameters were examined in rats following intravenous administration. 5'-N-ethylcarboxamidoadenosine (NECA) was by far the most potent analog in reducing mean arterial blood (PA) pressure while N6-(3-pentyl)-adenosine exerted the most potent bradycardic action. The N6-substituted (S)-diastereoisomers were substantially less potent in reducing PA and heart rate than NECA and the N6-substituted (R)-diastereoisomers. The cardiovascular effects of adenosine analogs persist, to varying degrees, much longer than those of adenosine itself.
D000241:Adenosine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D019830:Adenosine-5'-(N-ethylcarboxamide); D000262:Adenylyl Cyclases / Q000032:analysis; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D000242:Cyclic AMP / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D010660:Phenylisopropyladenosine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011983:Receptors, Purinergic / Q000502:physiology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D011983:Receptors, Purinergic; D010660:Phenylisopropyladenosine; D019830:Adenosine-5'-(N-ethylcarboxamide); D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D000241:Adenosine