Protein kinase C in astrocytes: a determinant of cell morphology.
Protein kinase C-like activity was found to be present in astrocytes prepared from rat neocortex and maintained in culture. Exposure to phorbol 12-myristate 13-acetate (PMA) caused a redistribution of this kinase from the cytosol to the membrane fraction of these cells. Also PMA was found to cause a profound change in astrocyte morphology; cells were converted from flat, polygonal, undifferentiated cells to process-bearing cells.
D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000032:analysis / Q000166:cytology / Q000201:enzymology*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000032:analysis; D004789:Enzyme Activation; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000242:Cyclic AMP; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate