[Hypoinsulinemia and bioenergetic processes in the rat cerebral cortex].
Increase in activity of lactate dehydrogenase, of its isoenzymes LDH1, LDH2 and LDH3 as well as in content of lactic acid with simultaneous decrease in the pyruvic acid content were found in brain hemispheres of rats with alloxan diabetes. A decrease in the rate of energy reactions in rat brain hemispheres, caused by impairment of glucose oxidation in the Krebs cycle, proved to be the specific property of metabolic alterations in these cells under conditions of hypoinsulinemia.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000201:enzymology / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000378:metabolism*; D004734:Energy Metabolism; D007328:Insulin / Q000097:blood*; D007527:Isoenzymes / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000227:Adenine Nucleotides; D007328:Insulin; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase
Gipoinsulinemiia i bioénergeticheskie protsessy v kore bol'shikh polushariĭ mozga krys.