A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types.
We have previously described the isolation of pH-2d-37, a cDNA clone that encodes a so far unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the corresponding gene, its nucleotide sequence, and its localization in the Tla region of the murine MHC. Using a RNase mapping assay, we have confirmed that the second domain coding region of the 37 gene displays very limited polymorphism, and that the gene is transcribed in a broad variety of cell types, in contrast to the genes encoding the known Qa and TL antigens. Possible functions are discussed.
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics*; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000032:analysis; D014018:Tissue Distribution
D006183:H-2 Antigens; D012333:RNA, Messenger; D004262:DNA Restriction Enzymes