[Importance of opiate receptor ligands in regulating lymphocyte proliferative activity].
Effects of morphine (10(-12)-10(-6) M), metenkephalin (10(-12)-10(-6) M), beta-endorphin (10(-12)-10(-6) M), dalargin--synthetic analogue of leu-enkephalin (10(-12)-10(-7) M) and naloxone (10(-8)-10(-6) M) on lymphocytes of the human peripheral blood stimulated by polyclonal mitogens were studied. It was shown that morphine (10(-8)-10(-6) M) and dalargin (10(-12)-10(-7) M) inhibited the lymphocyte proliferative activity induced by optimal doses of phytohemagglutinin; effects of morphine and dalargin were blocked by naloxone. It was also found that beta-endorphin (10(-11)-10(9) M) inhibited the proliferative activity of lymphocytes stimulated by pokeweed mitogen; naloxone failed to block beta-endorphin effect.
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004347:Drug Interactions; D004723:Endorphins / Q000494:pharmacology; D004745:Enkephalins / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*
D004723:Endorphins; D004745:Enkephalins; D008024:Ligands; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D011957:Receptors, Opioid; D009270:Naloxone; D009020:Morphine
Znachenie ligandov opiatnykh retseptorov v reguliatsii proliferativnoĭ aktivnosti limfotsitov.