Mapping and sequencing of a gene from myxoma virus that is related to those encoding epidermal growth factor and transforming growth factor alpha.
Myxoma virus, a Leporipoxvirus and agent of myxomatosis, was shown to possess a gene with the potential to encode an epidermal growth factorlike factor. Its relationship to other members of this family, including the poxvirus growth factors from Shope fibroma virus and vaccinia virus, was analyzed. Alignment of DNA sequences and related open reading frames of myxoma virus and Shope fibroma virus indicated colinearity of genes between these poxviruses.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004262:DNA Restriction Enzymes; D004815:Epidermal Growth Factor / Q000235:genetics*; D005796:Genes; D005814:Genes, Viral; D006133:Growth Substances / Q000235:genetics*; D009233:Myxoma virus / Q000235:genetics*; D009710:Nucleotide Mapping; D010455:Peptides / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D015291:Transforming Growth Factors
D006133:Growth Substances; D010455:Peptides; D004815:Epidermal Growth Factor; D015291:Transforming Growth Factors; D004262:DNA Restriction Enzymes