Mannose-resistant hemagglutination of human erythrocytes by enterotoxigenic Escherichia coli with colonization factor antigen II.
The human erythrocyte receptor which mediates mannose-resistant hemagglutination by enterotoxigenic Escherichia coli possessing colonization factor antigen II is not universally distributed among donors. Mannose-resistant hemagglutination-positive erythrocytes are more common among black donors than nonblack donors; tests with erythrocytes of known antigenic makeup confirm this correlation. Colonization factor antigen II receptor activity of mannose-resistant hemagglutination-positive erythrocytes is unstable when whole blood is stored at 4 degrees C. Also, screening of donors is best performed with enterotoxigenic E. coli possessing colonization factor antigen II composed of the coli surface antigen 1 (CS1) plus CS3, since these consistently produce stronger hemagglutination reactions than strains with colonization factor antigen II composed of either CS2 plus CS3 or CS3 only.
D000942:Antigens, Bacterial / Q000378:metabolism*; D044383:Black People; D004912:Erythrocytes / Q000276:immunology / Q000378:metabolism*; D004926:Escherichia coli / Q000276:immunology*; D036781:Fimbriae Proteins; D006384:Hemagglutination; D006801:Humans; D008358:Mannose / Q000494:pharmacology; D011446:Prospective Studies; D011971:Receptors, Immunologic / Q000032:analysis / Q000378:metabolism
D000942:Antigens, Bacterial; D011971:Receptors, Immunologic; C057522:colonization factor antigen II receptor; C022924:colonization factor antigens; D036781:Fimbriae Proteins; D008358:Mannose