Murine cytomegalovirus.
BALB/c and C57BL/6 mice were infected with murine cytomegalovirus (MCMV). On day 4 or 12 of the infection, the animals were immunized with SRBC (T-dependent), TNP-Ficoll (T-independent) and standard poliovirus. The adverse effect of the virus infection on humoral immune responses was limited to animals immunized on day 4; while anti-SRBC antibody formation was severely depressed in both mouse strains, reduced plaque forming cells to TNP-Ficoll were registered only in BALB/c mice. Antibodies to poliovirus were depressed in both strains, although to a lesser degree in C57Bl/6 than in BALB/c mice. Anti-SRBC B cell memory was found to be affected by MCMV infection. These results are interpreted to mean that T-dependent and -independent antigens may be handled differently by the two mouse strains tested.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000150:complications / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007114:Immunization; D007153:Immunologic Deficiency Syndromes / Q000209:etiology* / Q000276:immunology; D007156:Immunologic Memory; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D017955:Poliovirus / Q000276:immunology; D012756:Sheep; D014776:Virus Cultivation
D000914:Antibodies, Viral