Oxytocin increases arginine-induced A and B cell secretion in normal man and in diabetic subjects.
In previous in Vitro and in Vivo studies oxytocin was shown to stimulate A and B cell secretion. In the present study we show that oxytocin is also able to increase arginine-induced glucagon and insulin secretion in healthy human beings. Similar results were obtained in both insulin-dependent (type-1) and non-insulin dependent (type-2) diabetic subjects.
D000328:Adult; D001120:Arginine; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004357:Drug Synergism; D005934:Glucagon / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010121:Oxytocin; D012016:Reference Values
D007328:Insulin; D010121:Oxytocin; D005934:Glucagon; D001120:Arginine