The role of gamma-aminobutyric acid mechanisms of the zona incerta-lateral hypothalamus in the catalepsy and muscle rigidity evoked by morphine.
Picrotoxin or bicuculline were injected bilaterally into the zona incerta-lateral hypothalamus (ZI-LH) of the rat. Each drug (50 ng) inhibited or abolished the catalepsy induced by 20 mg/kg s.c. of morphine. Each drug also strongly inhibited the tonic electromyographic activity (EMG) induced by 10 mg/kg s.c. of morphine in the gastrocnemius soleus muscle (GS). The obtained results demonstrate participation of the ZI-LH in both catalepsy and rigidity induced by a systemic administration of morphine.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology*; D007026:Hypothalamic Area, Lateral / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D009020:Morphine; D009127:Muscle Rigidity / Q000139:chemically induced / Q000503:physiopathology*; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism; D013787:Thalamic Nuclei / Q000187:drug effects / Q000503:physiopathology*
D001640:Bicuculline; D009020:Morphine; D010852:Picrotoxin; D011963:Receptors, GABA-A