Effect of pancreatic glucagon and its 1-21 fragment on gastric emptying in man.
The effect of pancreatic glucagon (G) and its 1-21 fragment (G 1-21) on gastric emptying was studied in nine healthy volunteers. Gastric emptying of a 200-ml nutrient liquid meal was assessed during continuous infusion of physiologic saline, G, or G 1-21 in equimolar concentrations. The subjects were studied three times on separate days in randomized order. Gastric emptying was measured with a gamma camera technique. The emptying was diphasic in all studies, showing an initial plateau lasting 10-15 min followed by an exponential decline. During saline infusion the time necessary for 50% of the meal to leave the stomach was 32 +/- 4 min, compared with 30 +/- 4 min and 35 +/- 3 min during infusion of G and G 1-21, respectively. It is concluded that glucagon and its 1-21 fragment in physiologic concentrations do not seem to participate in the control of gastric emptying of a nutrient liquid meal.
D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005934:Glucagon / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000494:pharmacology; D011897:Random Allocation; D012965:Sodium Chloride / Q000008:administration & dosage
D010446:Peptide Fragments; C043386:glucagon (1-21); D012965:Sodium Chloride; D005934:Glucagon