Low A-esterase activity in serum of patients with fish-eye disease.
The activity of HDL-associated paraoxonase in the lipoprotein fraction of serum from two patients with fish-eye disease (FED) was only 11% of the mean value for control subjects. Similarly, concentrations of apolipoproteins A-I and A-II in the serum of FED subjects were only 10% of those in normal subjects. Thus the ratio of enzyme activity to A-I and A-II is virtually the same in these two groups of subjects. This suggests that paraoxonase activity of the lipoprotein fraction is associated with one or both of these apolipoproteins.
D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001054:Apolipoproteins A / Q000097:blood; D043303:Aryldialkylphosphatase; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003318:Corneal Opacity / Q000097:blood / Q000201:enzymology* / Q000235:genetics; D005260:Female; D006801:Humans; D010744:Phosphoric Monoester Hydrolases / Q000097:blood* / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001054:Apolipoproteins A; D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol; D010744:Phosphoric Monoester Hydrolases; D043303:Aryldialkylphosphatase