[Decrease of plasma prolactin in valproate therapy--expression of an increase in the activity of the central GABAergic system].
The effect of Valproat on plasma prolactin level in epileptic children with long term medication was investigated. Valproat was able to decrease plasma prolactin level significantly. This result is a sign of an increase in the central GABAergic system activity.
D000293:Adolescent; D001921:Brain / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D004832:Epilepsy, Absence / Q000097:blood / Q000188:drug therapy*; D004830:Epilepsy, Tonic-Clonic / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood*; D011963:Receptors, GABA-A / Q000187:drug effects*; D014635:Valproic Acid / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000097:blood
D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D011388:Prolactin
Plasma-Prolaktin-Erniedrigung unter Valproattherapie--Ausdruck einer Aktivitätssteigerung des zentralen GABAergen Systems.