[The so-called "contact" system of plasma: consequences of the activation of the Hageman factor].
The contact system of plasma includes 4 zymogens, Hageman factor, pre-kallikrein, factor XI and plasminogen, and a cofactor, the high molecular weight kininogen (HMWK). The activation of the contact system leads to the production of bradykinin, blood coagulation, fibrinolysis, complement activation and neutrophil stimulation. Consequently these phenomena generate a lot of pro-inflammatory factors which contribute to the local and systemic inflammatory processes.
D000818:Animals; D004792:Enzyme Precursors / Q000378:metabolism; D005172:Factor XI / Q000378:metabolism; D005174:Factor XII / Q000378:metabolism / Q000502:physiology*; D015956:Factor XIIa; D006801:Humans; D007704:Kininogens / Q000378:metabolism; D010958:Plasminogen / Q000378:metabolism; D011288:Prekallikrein / Q000378:metabolism; D012697:Serine Endopeptidases / Q000502:physiology*
D004792:Enzyme Precursors; D007704:Kininogens; D005174:Factor XII; D010958:Plasminogen; D005172:Factor XI; D011288:Prekallikrein; D012697:Serine Endopeptidases; D015956:Factor XIIa
Le système dit "de contact" du plasma: les conséquences de l'activation du facteur de Hageman.