title: Tolerability of hypertonic and isotonic contrast media injected intravenously. A comparative study in the dog.
abstract: We examined the use of isotonic and hypertonic contrast media injected intravenously in the dog from the standpoint of cardiovascular tolerance after right atrial injections performed at 2.56 and 5.12 g I/second. The parameters measured were lead II of the electrocardiograph, heart rate, pulmonary and abdominal arterial pressure, and aortic flow. Three contrast media, ioxitalamate, ioxaglate, and iopamidol (two ionic and one nonionic), were compared, either concentrated (32% iodine) or dilute and isotonic with plasma (ioxaglate 160 mg I/mL and iopamidol 128 mg I/mL). At an injection rate of 5.12 g I/second, iopamidol-128 showed lower electrophysiologic tolerability and caused a higher increase in aortic flow than ioxitalamate 160 or ioxaglate 160. These effects may explain the lower radiographic efficacy observed with iopamidol-128 in previous digital subtraction angiography studies.
mesh_terms: D000792:Angiography / Q000379:methods; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003287:Contrast Media / Q000633:toxicity*; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007275:Injections, Intravenous; D007479:Iopamidol / Q000633:toxicity; D007483:Iothalamic Acid / Q000031:analogs & derivatives / Q000633:toxicity; D007485:Ioxaglic Acid / Q000633:toxicity; D008297:Male; D011856:Radiographic Image Enhancement; D013382:Subtraction Technique
chemical_list: D003287:Contrast Media; D007483:Iothalamic Acid; C002587:ioxitalamic acid; D007479:Iopamidol; D007485:Ioxaglic Acid