Effects of food deprivation and high fat diet on opioid receptor binding in rat brain.
The effect of food deprivation for 72 h or a high fat diet on [3H]naloxone binding in the discrete brain regions of male lean Zucker rats was studied. In the midbrain, both treatments increased Bmax for the high-affinity site with no change in Kd. In the cortex, the high fat diet increased Bmax for the high-affinity site. These results suggest that dietary manipulations could produce significant changes in the endogenous opioid system.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage*; D005508:Food Deprivation / Q000502:physiology*; D008297:Male; D009270:Naloxone / Q000378:metabolism; D051381:Rats; D011924:Rats, Zucker; D011957:Receptors, Opioid / Q000378:metabolism*
D004041:Dietary Fats; D011957:Receptors, Opioid; D009270:Naloxone