title: Different behaviors among lysosomal enzymes in the cerebellum of jaundiced Gunn rats with cerebellar hypoplasia.
abstract: Activities of six lysosomal enzymes in the cerebellum of jaundiced homozygous (jj) Gunn rats were examined from 5 to 20 days of life and compared with those in heterozygotes (j+). Significantly higher enzyme activities were first detected at 8 days. The jj/j+ activity ratios of all enzymes peaked at 15 days. The ratios of beta-glycerophosphatase, beta-mannosidase, and acid lipase were only 1.3-1.7, whereas those of arylsulfatase and cathepsin were 2.0 and 3.1, respectively. The most striking increase in activity was observed with beta-glucuronidase, the ratio of which was 8.4. These results indicate a selective increase in activities of certain lysosomal enzymes in the hypoplastic cerebellum of jj rats.
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D002403:Cathepsins / Q000378:metabolism; D002526:Cerebellar Diseases / Q000201:enzymology* / Q000209:etiology / Q000473:pathology; D005966:Glucuronidase / Q000378:metabolism; D006867:Hydrolases / Q000378:metabolism*; D007565:Jaundice / Q000150:complications / Q000201:enzymology*; D008049:Lipase / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology*; D008361:Mannosidases / Q000378:metabolism; D009929:Organ Size; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D051381:Rats; D011911:Rats, Gunn; D044902:beta-Mannosidase
chemical_list: D006867:Hydrolases; D008049:Lipase; C020674:glycerol-2-phosphatase; D010744:Phosphoric Monoester Hydrolases; D001192:Arylsulfatases; D008361:Mannosidases; D044902:beta-Mannosidase; D005966:Glucuronidase; D002403:Cathepsins