Immunocytochemical demonstration of neuron-specific enolase for differential diagnosis of retroperitoneal tumours in children.
Six patients with malignant retroperitoneal tumours causing considerable diagnostic difficulties are reported. In a retrospective investigation the presence of neuron-specific enolase (NSE) was analysed immunocytochemically in specimens of these tumours. In all the patients who had finally got the definite diagnosis neuroblastoma, tumour specimens had a strong reaction for NSE whereas all other tumours did not react. An analysis of NSE already at the primary investigation could have led to an earlier definite diagnosis.
D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery; D008297:Male; D009447:Neuroblastoma / Q000473:pathology* / Q000601:surgery; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D012186:Retroperitoneal Neoplasms / Q000473:pathology* / Q000601:surgery; D014567:Urography; D009396:Wilms Tumor / Q000473:pathology / Q000601:surgery
D010751:Phosphopyruvate Hydratase