[Spontaneous and septal models of muricidal behavior: regional activity of enzymes regulating angiotensin and bradykinin metabolism in the brain].
Spontaneously muricidal rats (SMR) were selected from a group of white male rats. In the remaining animals muricide was induced by the local electrolyte damage of the brain septal area. Both muricidal models had different physiological indexes of aggressive reactions. In SMR a significant decrease in angiotensin-converting enzyme activity was detected in the midbrain and thalamus-hypothalamus areas. In the group of operated muricidal ("septal") rats alterations in angiotensin-converting enzyme activity have been revealed in none of the brain areas examined. The increase in total kinin-destroying activity in the pituitary, cerebellum, striatum and thalamus-hypothalamus areas was detected. The results indicate neurochemical specificity of brain angiotensin II and kinins in the regulation of different muricidal models.
D000374:Aggression / Q000502:physiology*; D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001920:Bradykinin / Q000378:metabolism*; D001921:Brain / Q000201:enzymology*; D004292:Dominance, Cerebral / Q000502:physiology*; D004572:Electrolysis; D008032:Limbic System / Q000502:physiology*; D008297:Male; D051379:Mice; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D051381:Rats
D000804:Angiotensin II; D007703:Peptidyl-Dipeptidase A; D001920:Bradykinin
Spontannaia i "septal'naia" modeli muritsidnosti: regionarnaia aktivnost' fermentov, reguliruiushchikh v mozge metabolizm angiotenzina i bradikinina.