title: The pro alpha 2(V) collagen gene is evolutionarily related to the major fibrillar-forming collagens.
abstract: A number of overlapping cDNA clones, covering 5.2 kb of sequences which code for the human pro alpha 2(V) collagen chain, have been isolated. Analysis of the structural data have indicated a close evolutionary kinship between the pro alpha 2(V) chain and the major fibrillar collagen types. Isolation and analysis of an 8 kb genomic fragment has further supported this notion by revealing a homologous arrangement of nine triple-helical domain exons. These studies have therefore provided conclusive evidence which categorizes the Type V collagen as a member of the Group 1 molecules, or fibrillar-forming collagens.
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D005075:Biological Evolution; D002460:Cell Line; D003001:Cloning, Molecular; D003094:Collagen / Q000235:genetics*; D004247:DNA / Q000378:metabolism; D004262:DNA Restriction Enzymes; D005347:Fibroblasts; D005354:Fibrosarcoma; D005796:Genes; D006801:Humans; D011347:Procollagen / Q000235:genetics*; D012208:Rhabdomyosarcoma; D012689:Sequence Homology, Nucleic Acid
chemical_list: D011347:Procollagen; D003094:Collagen; D004247:DNA; D004262:DNA Restriction Enzymes