title: Modulation of somatostatin binding sites in cytosol of rabbit gastric fundic mucosa by cysteamine administration.
abstract: Cysteamine, when given in vivo to rabbits, depleted immunoreactive somatostatin in rabbit gastric fundic mucosa. Depletion of immunoreactive somatostatin was associated with both an increase in the number and a decrease in the affinity of the low-affinity somatostatin binding sites. The in vitro incubation of cysteamine (0.1 mM) with the cytosolic fraction did not result in any modification of somatostatin binding. These results suggest that a decrease in the endogenous immunoreactive somatostatin might lead to up-regulation of somatostatin binding sites in the gastric fundic mucosa.
mesh_terms: D000818:Animals; D003543:Cysteamine / Q000494:pharmacology*; D003600:Cytosol / Q000378:metabolism; D005748:Gastric Fundus / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D007118:Immunoassay; D007457:Iodine Radioisotopes; D008297:Male; D011817:Rabbits; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D017481:Receptors, Somatostatin
chemical_list: D007457:Iodine Radioisotopes; D017981:Receptors, Neurotransmitter; D017481:Receptors, Somatostatin; D003543:Cysteamine