Autoradiographic localisation of NPY receptors in rabbit kidney: comparison with rat, guinea-pig and human.
In vitro labelling of neuropeptide Y binding sites with 125I-NPY was performed in rabbit kidney sections. Autoradiographic and histochemical techniques localised these binding sites to the proximal convoluted tubules and the vascular smooth muscle. In comparison, 125I-NPY binding was absent from the rat, guinea pig and human kidney. Possible physiological roles for the putative NPY receptors in rabbit renal function are discussed.
D000818:Animals; D001345:Autoradiography; D006168:Guinea Pigs; D006651:Histocytochemistry; D006801:Humans; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007668:Kidney / Q000033:anatomy & histology / Q000378:metabolism*; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D017476:Receptors, Neuropeptide Y; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D007457:Iodine Radioisotopes; D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y; D017981:Receptors, Neurotransmitter