title: Effect of epidural spinal cord stimulation on the activity of lateral vestibular nucleus neurons in the cat.
abstract: The activity of neurons in Deiters' lateral vestibular nucleus was recorded in decerebrate cats before, during and after spinal cord stimulation. An almost equal number of units were inhibited and excited early during stimulation. Later during stimulation the majority of units was inhibited. Early after cessation of stimulation an ever larger number of units were inhibited to an even larger extent (for about 2 imp/s on the average). Later after stimulus cessation the predominant inhibitory effect could still be noted, as well as excitation in some units. The results could support the hypothesis that the inhibition of Deiters' neurons during and for some time after epidural cord stimulation may play a part in the decrease of limb spasticity. The mechanism of inhibitory and excitatory unitary responses, side effects during stimulation and differences between the experimental model and human state are discussed.
mesh_terms: D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D004824:Epidural Space; D009132:Muscles / Q000294:innervation; D009433:Neural Inhibition; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology; D013116:Spinal Cord / Q000502:physiology*; D009435:Synaptic Transmission; D014726:Vestibular Nuclei / Q000502:physiology*; D003689:Vestibular Nucleus, Lateral / Q000502:physiology