Clinical and treatment effects on 3H-clonidine and 3H-imipramine binding in elderly depressed patients.
3H-clonidine and 3H-imipramine binding were measured in depressed patients, 55 years and older. There was no significant difference in either 3H-clonidine or 3H-imipramine binding between depressed patients and age- and sex-matched controls. There was no significant correlation between 3H-clonidine or 3H-imipramine binding and severity of depression before treatment. There was a significant negative correlation between the KD of 3H-imipramine binding sites and Hamilton score over seven weeks of antidepressant treatment. There was no significant difference between receptor data of responders and nonresponders to antidepressant treatment.
D001792:Blood Platelets / Q000378:metabolism; D002352:Carrier Proteins; D003000:Clonidine / Q000378:metabolism*; D003866:Depressive Disorder / Q000188:drug therapy / Q000378:metabolism*; D004311:Double-Blind Method; D006801:Humans; D054755:Imidazoline Receptors; D007099:Imipramine / Q000378:metabolism*; D007700:Kinetics; D008875:Middle Aged; D009661:Nortriptyline / Q000627:therapeutic use; D010624:Phenelzine / Q000627:therapeutic use; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D018341:Receptors, Adrenergic, alpha-2; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D002352:Carrier Proteins; D054755:Imidazoline Receptors; D011942:Receptors, Adrenergic, alpha; D018341:Receptors, Adrenergic, alpha-2; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D009661:Nortriptyline; D003000:Clonidine; D010624:Phenelzine; D007099:Imipramine