Polyclonal chromosomal evolution in a benign mixed salivary gland tumor.
Banding analyses of a human benign pleomorphic adenoma in the parotid gland revealed a polyclonal pattern where structural rearrangements predominated. These deviations were different from the anomalies previously observed in 100 mixed tumors. The reason found for the differences in all likelihood was x-ray treatment of tuberculous lymphadenitis in the neck during childhood. Implications regarding origin and development of pleomorphic adenomas are discussed.
D008949:Adenoma, Pleomorphic / Q000235:genetics*; D000368:Aged; D002869:Chromosome Aberrations / Q000528:radiation effects; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D009333:Neck; D009381:Neoplasms, Radiation-Induced / Q000235:genetics; D010307:Parotid Neoplasms / Q000235:genetics*; D014388:Tuberculosis, Lymph Node / Q000532:radiotherapy
D005819:Genetic Markers