title: [Relative biological effectiveness (RBE) of neutrons produced by 50 MeV deuterons and by 34, 45, 65 and 75 MeV protons].
abstract: RBE of p(34) + Be, p(45) + Be, p(65), + Be, p(75) + Be and d(50) + Be neutron beams produced at the cyclotron "Cyclone" of Louvain-la-Neuve were measured. The biological criterion was the regeneration of the crypts of the intestinal mucosa (50 regenerated crypts per circumference) after abdominal irradiation in mice. Taking the p(65) + Be neutrons as reference, RBE values were found equal to 1.12, 1.07, 1.00 (Ref.), 0.96 and 1.02 respectively. These results are consistent with those published for cell lethality in vitro. However, the RBE variation is smaller than this previously obtained in the laboratory for growth inhibition in Vicia faba.
mesh_terms: D000201:Activation Analysis; D000818:Animals; D003903:Deuterium / Q000627:therapeutic use; D007413:Intestinal Mucosa / Q000502:physiology / Q000528:radiation effects; D051379:Mice; D009501:Neutron Activation Analysis; D011522:Protons; D012038:Regeneration; D012062:Relative Biological Effectiveness
chemical_list: D011522:Protons; D003903:Deuterium
vernacular_title: Efficacité biologique relative (EBR) des neutrons produits à partir de deutons de 50 MeV et de protons de 34, 45, 65 et 75 MeV.