Study on the interaction of Se and erythrocyte membrane--effect of Se on the Na, K-ATPase activity and fluidity of erythrocyte membranes.
The content of binding-Se in erythrocyte membrane may affect its structure and function. Decrease in Se content will lead to a lower activity of Na, K-ATPase and lipid fluidity in ghosts, and a marked increase in Na, K-ATPase activity as well as lipid fluidity of erythrocyte membrane was observed by supplementation of low concentration of Na2SeO3 (0.03-0.3 ppm Se), in vitro. This effect was obvious only when the ghosts were incubated with Se at 0-4 degrees C for at least half an hour prior to assay.
D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D008560:Membrane Fluidity / Q000187:drug effects*; D012643:Selenium / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D000254:Sodium-Potassium-Exchanging ATPase; D012643:Selenium