[Effect of oxidative phosphorylation inhibitors and uncoupling agents on cAMP activity].
Uncouplers of oxidative phosphorylation increased the speed of substrate oxidation and ATP hydrolysis and raised cAMP induced neuron membrane current. Different inhibitors decreased it. Both effects support the hypothesis that a signal of intracellular injected cAMP spreads to the neuron membrane as a mechanical signal. This signal propagated to the membrane along microtubules which according to this hypothesis serve as a sound generator with metabolic heat pumping.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D003864:Depression, Chemical; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008954:Models, Biological; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D014475:Uncoupling Agents / Q000494:pharmacology*
D014475:Uncoupling Agents; D000242:Cyclic AMP
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