Protective effects of liposome-entrapped superoxide dismutase on posttraumatic brain edema.
Oxygen-derived free radicals and membrane lipid peroxidation have been postulated to be involved in brain edema and cell death, secondary to ischemia and traumatic injury. Using a model of brain edema induced by cold-induced injury, we have demonstrated an early elevation of superoxide radicals followed by permeability changes in the blood-brain barrier and development of edema in injured brain. Intravenous injection of liposome-entrapped copper-zinc-superoxide dismutase 5 minutes before the injury-enhanced entry of the enzyme into endothelial cells of the blood-brain barrier of injured brain reduced the brain level of superoxide radicals and ameliorated blood-brain barrier permeability changes and brain edema. Identical treatment 5 minutes after injury was also effective. These data demonstrate that superoxide radicals play an important role in the delayed development of vasogenic brain edema following brain injury.
D000818:Animals; D001812:Blood-Brain Barrier; D001923:Brain Chemistry; D001929:Brain Edema / Q000517:prevention & control*; D001930:Brain Injuries / Q000188:drug therapy* / Q000378:metabolism; D003080:Cold Temperature / Q000009:adverse effects; D005609:Free Radicals; D008081:Liposomes / Q000008:administration & dosage; D051381:Rats; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000627:therapeutic use*; D013481:Superoxides / Q000032:analysis
D005609:Free Radicals; D008081:Liposomes; D013481:Superoxides; D013482:Superoxide Dismutase