Org.2766 protects from cisplatin-induced neurotoxicity in rats.
One of the side-effects of the cytotoxic drug, cisplatin, is its neurotoxicity. In rats this neurotoxicity can be measured as a slowing of the H-reflex-related sensory nerve conduction velocity. Concurrent treatment with Org.2766 (an ACTH4-9 analog) prevents this neurotoxic side effect while leaving the antitumor activity of cisplatin unaffected.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002945:Cisplatin / Q000627:therapeutic use / Q000633:toxicity*; D005260:Female; D006181:H-Reflex / Q000187:drug effects; D009132:Muscles / Q000502:physiology; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009431:Neural Conduction / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects* / Q000502:physiology; D010446:Peptide Fragments / Q000494:pharmacology*; D010525:Peripheral Nerves / Q000187:drug effects* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains
D000927:Anticonvulsants; D010446:Peptide Fragments; C013765:Org 2766; D000324:Adrenocorticotropic Hormone; D002945:Cisplatin