title: Interstitial pneumonitis following autologous bone marrow transplantation.
abstract: The incidence of interstitial pneumonitis (IP) was reviewed in 70 consecutive patients who received autologous marrow transplants for hematologic malignancies. All patients were treated with total-body irradiation (TBI), with or without other chemotherapeutic agents. Seven patients (10%) developed IP, 3 were due to cytomegalovirus, 1 due to Pneumomcystis carinii, and 3 of unknown cause (idiopathic). Risk factors for developing IP were increasing age and a prior history of irradiation to the chest. The use of methotrexate posttransplant did not increase the incidence of IP.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000032:analysis; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000209:etiology; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects; D008875:Middle Aged; D011183:Postoperative Complications; D011658:Pulmonary Fibrosis / Q000209:etiology*; D014182:Transplantation, Autologous; D014916:Whole-Body Irradiation
chemical_list: D000914:Antibodies, Viral; D008727:Methotrexate