title: [Joint amplification of c-myc and c-Ha-ras oncogenes in human breast and thyroid cancer cells].
abstract: Both c-myc and c-Ha-ras 1 oncogenes amplification and enhanced expression were revealed in some human mammary and thyroid carcinomas by the molecular genetic analysis. Amplification proves to be a second possible molecular mechanism of the ras family protooncogene activation besides a point mutation. The coexistence of c-myc and c-Ha-ras 1 in some human primary carcinomas suggests a multistep process of carcinogenesis.
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D004262:DNA Restriction Enzymes; D004273:DNA, Neoplasm / Q000235:genetics; D005784:Gene Amplification; D006801:Humans; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes; D013964:Thyroid Neoplasms / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm; D004262:DNA Restriction Enzymes
vernacular_title: Sovmestnaia amplifikatsiia onkogenov c-myc i c-Ha-ras v kletkakh raka molochnoĭ i shchitovidnoĭ zhelezy cheloveka.