A role for glucocorticoids in the polyphosphoinositide second messenger system.
Glucocorticoids have been shown to be involved in numerous secretory and activation processes which are known to be mediated by the polyphosphoinositide second messenger system. A connection between glucocorticoids and the polyphosphoinositide system has not been made because of the marked temporal differences in their effects and the fact that most of the known effects of glucocorticoids involve transcription and/or protein synthesis. An attempt is made to to rationalize these apparent incongruities. The recently reported stimulation of glucose transport by kinase C suggests an experimental system to investigate glucocorticoid effects on the polyphosphoinositide system.
D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D015232:Dinoprostone; D005938:Glucocorticoids / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008222:Lymphokines / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D012333:RNA, Messenger / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D014158:Transcription, Genetic
D005938:Glucocorticoids; D008222:Lymphokines; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D011458:Prostaglandins E; D012333:RNA, Messenger; D011493:Protein Kinase C; D005947:Glucose; D015232:Dinoprostone; D002118:Calcium