[The biological action spectrum of the secretory products of the human B-cell lymphoblastoid line RPMI-641Ot].
Secretory products of the lymphoblastoid line of human B-cells RPMI-6410t have a wide spectrum of biological activity. These products exert a growth-stimulating effect on B-cells of the 6410t strain obtained from the peripheral blood of a patient with acute myeloblastic leukemia and cytotoxic and cytostatic effects, respectively, on B-cells of the Raji and P3HR-I.G5 lines obtained from patients with Burkitt's lymphoma. They also exert a cytotoxic effect on murine L-cells. Biological activity is relieved at 70 degrees and at low and high pH.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000502:physiology*; D001685:Biological Factors / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity; D002051:Burkitt Lymphoma / Q000097:blood; D002460:Cell Line; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002999:Clone Cells / Q000187:drug effects / Q000502:physiology; D016207:Cytokines; D006801:Humans; D007739:L Cells; D015470:Leukemia, Myeloid, Acute / Q000097:blood; D008222:Lymphokines / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity; D051379:Mice
D001685:Biological Factors; D016207:Cytokines; D008222:Lymphokines
Spektr biologicheskogo deĭstviia sekretornykh produktov limfoblastoidnoĭ linii B-kletok cheloveka RPMI-641Ot.