title: Proliferation of human testicular tumours.
abstract: Whole tumour perfusion with radioactive DNA precursors reveals that proliferation of human testicular tumours differs widely depending on type and stage of development. In seminomas a homogeneous distribution of proliferating cells at early stages is followed by a shift of the growth fraction to the periphery at advanced stage. Embryonal carcinomas show a chessboard-like pattern of proliferating fractions with high 3H-thymidine labelling indices and short tpot. In mature teratomas proliferation is low. It increases in immature teratocarcinomas. Lack of proliferation is observed in beta-hCG-positive syncytiotrophoblastic cells of choriocarcinomas, the growth fraction being limited to the cytotrophoblastic compartment.
mesh_terms: D000328:Adult; D001345:Autoradiography; D002455:Cell Division; D002822:Choriocarcinoma / Q000473:pathology; D004261:DNA Replication; D004273:DNA, Neoplasm / Q000032:analysis; D004407:Dysgerminoma / Q000473:pathology; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology*; D013724:Teratoma / Q000473:pathology; D013736:Testicular Neoplasms / Q000473:pathology*; D014316:Tritium
chemical_list: D004273:DNA, Neoplasm; D014316:Tritium