title: Serum isoforms of creatine kinase isoenzymes.
abstract: The CK-2 and CK-3 isoenzymes of human serum creatine kinase (CK) can be further subdivided into five isoforms (subforms derived from the same isoenzyme). Three are derived from CK-3 and two from CK-2. The formation of these isoforms is a postsynthetic phenomenon brought about by a serum carboxypeptidase that acts on the M monomer of the enzyme. Sera from healthy subjects contain CK-3(1) as the dominant isoform with lesser amounts of CK-3(2) and CK-3(3). Following damage of muscle tissue, the serum isoform distribution changes as a result of the increased release of CK enzyme. This provides more diagnostic information concerning acute myocardial infarction and other muscle diseases than is available from routine CK isoenzyme analysis.
mesh_terms: D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D007526:Isoelectric Point; D007527:Isoenzymes; D012016:Reference Values; D009626:Terminology as Topic
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase