Thiyl free radicals and the oxidation of ferrocytochrome c. Direct observation of coupled hydrogen-atom- and electron-transfer reactions.
Absolute rate constants for the reaction of ferrocytochrome c with the thiyl radicals derived from cysteine, GSH, penicillamine and N-(2-mercaptopropionyl)glycine were measured by using the technique of pulse radiolysis. The reaction is believed to occur through a one-electron-transfer process, in agreement with the hypothesis that thiols may act as catalysts linking hydrogen-atom- and electron-transfer reactions.
D003574:Cytochrome c Group / Q000378:metabolism*; D004579:Electron Transport; D005609:Free Radicals; D007700:Kinetics; D010084:Oxidation-Reduction; D011675:Pulse Radiolysis; D013438:Sulfhydryl Compounds / Q000378:metabolism*
D003574:Cytochrome c Group; D005609:Free Radicals; D013438:Sulfhydryl Compounds