[Leukocyte migration inhibiting factor in preparations of alpha and gamma interferons].
High titres of leukocyte migration inhibition factor (LMIF) activity were found in native and partially purified preparations of human alpha- and gamma-interferon. In the course of chemical purification of interferon up to 98% of LMIF was lost. The highest content of LMIF was in gamma-interferon preparations, while recombinant alpha 2-interferon (reaferon) showed no LMIF activity.
D002464:Cell Migration Inhibition; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D006801:Humans; D007370:Interferon Type I / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D007371:Interferon-gamma / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D007961:Leukocyte Migration-Inhibitory Factors / Q000032:analysis* / Q000494:pharmacology; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology; D008222:Lymphokines / Q000032:analysis*; D011994:Recombinant Proteins / Q000032:analysis / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D007370:Interferon Type I; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines; D011994:Recombinant Proteins; D007371:Interferon-gamma
Faktor, ingibiruiushchiĭ migratsiiu leĭkotsitov v preparatakh al'fa- i gamma-interferona.