title: Management of an oroantral fistula in a patient with Wilson's disease: case report and review of the literature.
abstract: After removal of an impacted maxillary third molar, an oroantral fistula developed in a patient with Wilson's disease. Management consisted of antibiotics, decongestants, irrigation, and surgical closure. Complications of treatment did not directly involve the disease but, rather, were related to the therapeutic agent penicillamine. Penicillamine causes interference between the cross links of tropocollagen molecules and cleaves newly formed molecules. Reduction in dosage is recommended when surgery is planned to increase collagen formation and, thus, healing. Such a measure was undertaken in this case. The patient healed uneventfully. A review of Wilson's disease and a case report are presented.
mesh_terms: D000328:Adult; D006527:Hepatolenticular Degeneration / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery; D009957:Oroantral Fistula / Q000209:etiology / Q000601:surgery*; D010396:Penicillamine / Q000009:adverse effects; D013290:Streptococcal Infections / Q000150:complications; D014081:Tooth Extraction / Q000009:adverse effects; D014095:Tooth, Impacted / Q000601:surgery
chemical_list: D010396:Penicillamine