Failure of ACTH to alter transfer kindling in the immature brain.
For a study of the effects of ACTH on established seizures, 16-day-old rats that had been previously kindled in the amygdala were given a high daily dosage of ACTH gel for 15 days and then underwent transfer kindling in the contralateral amygdala. There were no significant differences in the rate of transfer kindling between the controls and ACTH-treated rats. This study indicates that in the immature animal ACTH does not alter the kindled state.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000679:Amygdala / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000209:etiology* / Q000503:physiopathology
D000324:Adrenocorticotropic Hormone