One-electron reduction of an anthracycline antibiotic carminomycin by a human erythrocyte redox chain.
Human erythrocyte membranes catalyse the NAD(P)H-dependent generation of the semiquinone of an adriamycin-type antibiotic carminomycin under anaerobic conditions. The maximal yield of the antibiotic radical is about 4-fold higher in the presence of NADPH than of NADH. The possible significance of the antibiotic reduction to the semiquinone by a human erythrocyte membrane redox chain for the clinical usage of these antibiotics is discussed.
D002360:Carubicin / Q000097:blood*; D003630:Daunorubicin / Q000031:analogs & derivatives*; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005609:Free Radicals; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D009243:NAD / Q000494:pharmacology; D009249:NADP / Q000494:pharmacology; D010084:Oxidation-Reduction
D005609:Free Radicals; D009243:NAD; D009249:NADP; D002360:Carubicin; D003630:Daunorubicin