Alpha-thalassemia haplotypes in the Algerian population.
DNA mapping was performed in seven unrelated Hb H patients and nine carriers for alpha-thalassemia trait originating from Algeria. This study has allowed us to identify four alpha-thalassemia haplotypes: the (-alpha 3.7) haplotype, which is the most frequent (18 of 23 alpha-thalassemic chromosomes), the (-(alpha)20.5) haplotype, a (--) haplotype, and an (alpha alpha)T haplotype. Our results also show that the (-alpha 3.7) haplotypes encountered in the Algerian population are heterogeneous and differ by the site of the unequal crossover responsible for the 3.7-kb deletion and the size of the interzeta fragment. In addition, during this survey we observed that normal chromosomes bearing a polymorphic BglII site are associated with different interzeta fragments.
D000462:Algeria; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005838:Genotype; D005914:Globins / Q000235:genetics*; D006447:Hemoglobin H / Q000235:genetics; D006801:Humans; D009693:Nucleic Acid Hybridization; D013789:Thalassemia / Q000235:genetics*
D005914:Globins; D004247:DNA; D006447:Hemoglobin H; D004262:DNA Restriction Enzymes