[Relationships between structure and activity of anthracycline antibiotics of the rhodomycin group: inhibition kinetics of DNA and RNA viruses of the double- and single-strand types].
Antiviral activity from anthracycline antibiotics of rhodomycin-type was investigated by two independent methods, which determined the infectious units and antigenity of incomplete virions. The action of rhodomycin was dependent on structure, number and position of amino sugar, which is in aglycon. The viruses of double-stranded DNA and RNA viruses was stronger inhibited as single-stranded RNA viruses. The antiviral activity were found to increase in the serial order iremycin less than adriamycin less than daunomycin less than alpha-rubicin I less than beta-rhodomycin I less than violamycin BI-complex by inhibition kinetic determined from Adeno virus.
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D000998:Antiviral Agents; D004267:DNA Viruses / Q000187:drug effects*; D004277:DNA, Single-Stranded / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D010783:Photometry; D012328:RNA Viruses / Q000187:drug effects*; D012367:RNA, Viral / Q000378:metabolism; D013329:Structure-Activity Relationship
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000998:Antiviral Agents; D004277:DNA, Single-Stranded; D012367:RNA, Viral; C004977:rhodomycin
Beziehungen zwischen Struktur und Wirkung von Anthracyclin-Antibiotika der Rhodomycingruppe: Hemmungskinetik der DNS- und RNS-Viren vom Doppelstrang- und Einstrang-Typ.