Peripheral benzodiazepine binding sites on platelet membranes are increased during diazepam treatment of anxious patients.
Reduced (24%) [3H]PK 11195 binding capacity to platelet membranes was observed in anxious patients in comparison to age- and sex-matched normal controls. Four weeks of diazepam treatment induced elevation (69%) in the maximal number of binding sites, and 1 week of drug withdrawal resulted in a slight decrease (16%) in 'peripheral' benzodiazepine binding sites as compared to their level during treatment.
D000328:Adult; D001007:Anxiety / Q000097:blood* / Q000188:drug therapy / Q000523:psychology; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003975:Diazepam / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000097:blood; D007700:Kinetics; D008297:Male; D011569:Psychiatric Status Rating Scales; D011963:Receptors, GABA-A / Q000378:metabolism*; D013375:Substance Withdrawal Syndrome / Q000378:metabolism
D007546:Isoquinolines; D011963:Receptors, GABA-A; D003975:Diazepam; C037850:PK 11195