Bone changes in alcoholic liver cirrhosis. A histomorphometrical analysis of 52 cases.
Bone biopsies of 52 histologically confirmed alcoholic cirrhotic patients and 15 age- and sex-matched controls have been histomorphometrically analyzed determining trabecular bone volume (TBV), mineralized bone volume (MBV), and osteoid volume (OV). We also determined serum PTH, 25-OH-D3, calcitonin, FSH, LH, estradiol, testosterone, T3 and T4, urine cortisol, routine liver function tests, serum and urinary calcium, phosphorus, and magnesium. We found a high prevalence of osteoporosis: TBV was significantly lower in cirrhotic patients (T = 7.23, P less than 0.001), 41 of them being in the range of osteoporosis; none of them had osteomalacia. Levels of all the above-mentioned hormones and electrolytes were almost normal, and no correlation was found between them and liver function tests, as occurred with the bone parameters.
D000328:Adult; D000368:Aged; D001706:Biopsy; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology*; D002118:Calcium / Q000097:blood / Q000652:urine; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D008099:Liver / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000378:metabolism / Q000473:pathology*; D008274:Magnesium / Q000097:blood / Q000652:urine; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000097:blood / Q000652:urine
D006728:Hormones; D010758:Phosphorus; D008274:Magnesium; D002118:Calcium