Oxidative metabolism and glycolysis in benign brain tumors.
Glucose utilization in vivo and hexokinase activity and mitochondrial oxygen consumption in vitro were measured in a series of human brain tumors. Several relatively slow-growing tumors appeared to have depressed electron-transport activities coupled with a compensatory elevated glucose utilization. These data suggest that a decrease in oxidative metabolism and a corresponding increase in glycolysis are not necessarily correlated with malignancy in certain human brain tumors.
D001932:Brain Neoplasms / Q000378:metabolism*; D003847:Deoxyglucose / Q000031:analogs & derivatives; D003576:Electron Transport Complex IV / Q000378:metabolism; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis; D006593:Hexokinase / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D009245:NADH Dehydrogenase / Q000378:metabolism; D010101:Oxygen Consumption
D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV; D006593:Hexokinase; D005947:Glucose