6-Methylpurine, 6-methyl-9-beta-D-ribofuranosylpurine, and 6-hydroxymethyl-9-beta-D-ribofuranosylpurine as antiviral metabolites of Collybia maculata (Basidiomycetes).
6-Methylpurine, 6-methyl-9-beta-D-ribofuranosylpurine and 6-hydroxymethyl-9-beta-D-ribofuranosylpurine were isolated from mycelial cultures of Collybia maculata and their antifungal, cytotoxic and antiviral activities investigated. This is the first report on the natural occurrence of these compounds.
D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001487:Basidiomycota / Q000254:growth & development*; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007700:Kinetics; D051379:Mice; D009700:Nucleoside Deaminases / Q000037:antagonists & inhibitors*; D011684:Purine Nucleosides / Q000302:isolation & purification* / Q000494:pharmacology; D011687:Purines / Q000302:isolation & purification* / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects
D058892:Adenosine Deaminase Inhibitors; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D011684:Purine Nucleosides; D011687:Purines; C034051:6-methylpurine riboside; C016588:6-methylpurine; C053127:6-hydroxymethylpurine riboside; D009700:Nucleoside Deaminases