Effect of recombinant human interferon gamma against human cytomegalovirus.
Escherichia coli-derived human interferon-gamma (rIFN-gamma) inhibited the replication of human cytomegalovirus (HCMV) synergistically when combined with IFN-alpha. The induction of HCMV DNA polymerase was inhibited in rIFN-gamma-treated cells. It is suggested that the induction of 2-5 A synthetase does not play an important role in the anti-HCMV actions of IFNs.
D015088:2',5'-Oligoadenylate Synthetase / Q000096:biosynthesis; D003587:Cytomegalovirus / Q000201:enzymology / Q000502:physiology*; D004259:DNA-Directed DNA Polymerase / Q000096:biosynthesis; D004790:Enzyme Induction; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D010948:Viral Plaque Assay; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication
D007370:Interferon Type I; D011994:Recombinant Proteins; D014764:Viral Proteins; D007371:Interferon-gamma; D004259:DNA-Directed DNA Polymerase; D015088:2',5'-Oligoadenylate Synthetase