title: Histopathological changes in the eyes of mangabey monkeys with lepromatous leprosy.
abstract: Leprosy is the third leading cause of preventable blindness; however, little is known about the spread of infection to the eye. We have studied the eyes of three sooty managabey monkeys. Two were experimentally infected with Mycobacterium leprae; the third was not infected. In one of the infected animals there was histopathological evidence of lepromatous leprosy as evidenced by a chronic inflammatory infiltrate at the limbus, and detection of acid-fast bacilli in the corneal stroma, blood vessel walls, and corneal nerves. The latter were damaged as a result of the bacillary invasion. Electron microscopy revealed involvement and distortion of keratocytes with M. leprae and invasion of the corneal stroma by macrophages containing bacilli. Both infected animals showed focal collections of lymphocytes in the superficial stroma of the conjunctiva and in the ciliary body. This is the first report of the ocular manifestations of leprosy in any primate, including man, in which the duration of infection is known.
mesh_terms: D000818:Animals; D002520:Cercopithecidae; D003315:Cornea / Q000382:microbiology / Q000473:pathology / Q000648:ultrastructure; D005123:Eye / Q000382:microbiology / Q000473:pathology* / Q000648:ultrastructure; D005128:Eye Diseases / Q000473:pathology*; D005260:Female; D007918:Leprosy / Q000473:pathology*; D008264:Macrophages / Q000382:microbiology; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009166:Mycobacterium leprae / Q000648:ultrastructure