Studies of a common idiotype PR4 in autoimmune rheumatic disease.
A new common idiotype, designated PR4, is described. This idiotype was originally identified on a human hybridoma-derived monoclonal antibody from a patient with leprosy, which binds the major Mycobacterium leprae-derived antigen, phenolic glycolipid-1, poly(ADP)-ribose, DNA, and poly(dT). The PR4 idiotype was found in patients with systemic lupus erythematosus (SLE) (70%), rheumatoid arthritis (40%), and Sjögren's syndrome (15%). It was not, however, found in the spouses of the SLE patients or (unlike other lupus idiotypes) in their healthy first-degree relatives. Although no correlation between PR4 idiotype levels and disease activity in SLE was found, a subset of rheumatoid arthritis patients with high levels of the idiotype was identified.
D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D004247:DNA / Q000378:metabolism; D004277:DNA, Single-Stranded / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000032:analysis*; D007136:Immunoglobulins / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology / Q000503:physiopathology; D009166:Mycobacterium leprae / Q000276:immunology; D012016:Reference Values; D012216:Rheumatic Diseases / Q000276:immunology*; D012720:Severity of Illness Index; D012859:Sjogren's Syndrome / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000942:Antigens, Bacterial; D004277:DNA, Single-Stranded; D007130:Immunoglobulin Idiotypes; D007136:Immunoglobulins; D004247:DNA