The bisphosphonomethyl analogue of 2,3-bisphosphoglycerate inhibits yeast but not wheat-germ phosphoglycerate mutase.
The bisphosphonomethyl analogue of 2,3-bisphosphoglycerate [4-phosphono-2-(phosphonomethyl) butanoate] was a potent competitive inhibitor of cofactor-dependent phosphoglycerate mutase from yeast, with a Ki of 0.8 mM. In contrast, the analogue did not affect the activity of cofactor-independent phosphoglycerate mutase from wheat germ. It is considered that this compound should be particularly useful for n.m.r. spectroscopic studies on the mechanism of action of cofactor-dependent phosphoglycerate mutases.
D019794:2,3-Diphosphoglycerate; D002087:Butyrates / Q000494:pharmacology*; D004163:Diphosphoglyceric Acids; D004164:Diphosphonates / Q000494:pharmacology*; D007700:Kinetics; D010736:Phosphoglycerate Mutase / Q000037:antagonists & inhibitors*; D010770:Phosphotransferases / Q000037:antagonists & inhibitors*; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D014908:Triticum / Q000201:enzymology*
D002087:Butyrates; D004163:Diphosphoglyceric Acids; D004164:Diphosphonates; D019794:2,3-Diphosphoglycerate; C053162:4-phosphono-2-(phosphonomethyl)butanoate; D010770:Phosphotransferases; D010736:Phosphoglycerate Mutase