A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse.
Hereditary hypogonadism in the hypogonadal (hpg) mouse is caused by a deletional mutation of at least 33.5 kilobases encompassing the distal half of the gene for the common biosynthetic precursor of gonadotropin-releasing hormone (GnRH) and GnRH-associated peptide (GAP). The partially deleted gene is transcriptionally active as revealed by in situ hybridization histochemistry of hpg hypothalamic tissue sections, but immunocytochemical analysis failed to show the presence of antigen corresponding to any part of the precursor protein.
D000818:Animals; D001483:Base Sequence; D001923:Brain Chemistry; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000235:genetics*; D006651:Histocytochemistry; D007006:Hypogonadism / Q000235:genetics*; D051379:Mice; D009693:Nucleic Acid Hybridization; D011498:Protein Precursors / Q000235:genetics*; D014158:Transcription, Genetic
D011498:Protein Precursors; C050502:gonadotropin releasing hormone associated peptide; D007987:Gonadotropin-Releasing Hormone; D004262:DNA Restriction Enzymes