Noradrenergic mechanisms in the response to dextroamphetamine in humans.
The effect of oral thymoxamine, an alpha-noradrenergic antagonist, on the arousal and anorectic action of oral dextroamphetamine was measured in order to investigate the role of the alpha-noradrenergic pathways in these responses. Thymoxamine appeared to accentuate the alerting action and reduce the anorectic action of dextroamphetamine. The implications of these findings on the role of the alpha-noradrenergic pathways in these responses is discussed in the light of previous findings.
D000328:Adult; D001066:Appetite / Q000187:drug effects; D001143:Arousal / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D013948:Moxisylyte / Q000494:pharmacology; D009434:Neural Pathways / Q000502:physiology; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*
D011942:Receptors, Adrenergic, alpha; D013948:Moxisylyte; D003913:Dextroamphetamine