[Effect of coenzyme A (COA) on the 6-keto-prostaglandin F1 alpha content of the aorta of rats made diabetic with streptozotocin. Potential mechanism of action of its favorable effect on microcirculatory disorders in man].
The production of 6-keto-prostaglandin F1 alpha, a stable metabolite of the vasodilator prostacyclin (PGI2), by fragments of the thoracic aorta of rats made diabetic by streptozotocin, was evaluated by radio-immunological assay. The level of production was found to be statistically higher (p less than or equal to 0.01) in the group treated with Coenzyme A (CoA) than in the placebo group. The authors suggest that the mode of action of CoA 1000 much greater than in microcirculatory pathology could involve an increased production of vasodilator prostacyclin.
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis*; D000328:Adult; D000818:Animals; D001012:Aorta, Abdominal / Q000378:metabolism*; D003065:Coenzyme A / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D011464:Epoprostenol / Q000096:biosynthesis; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D014652:Vascular Diseases / Q000378:metabolism
D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol; D003065:Coenzyme A
Influence du coenzyme A (COA) sur la teneur en 6 ceto prostaglandine F1 alpha d'aortes de rats rendus diabétiques par la streptozotocine. Mécanismes d'action possible de son effet bénéfique sur les perturbations microcirculatoires chez l'homme.