Effect of N-acetyl-DL-homocysteine thiolactone and 2,3-dimercaptosuccinic acid on the restoration of alkaline phosphatase in the nervous system of rat during methylmercury toxication.
The study deals with alkaline phosphatase (ALK) changes in methylmercury chloride (MMC) and the antagonists, N-acetyl-DL-homocysteine thiolactone (NAHT) and 2,3-dimercaptosuccinic acid (DSA) treated rats. A daily dose of 10 mg/kg of MMC was given to the animals for two days, seven days, and fifteen days. The animals were sacrificed on third day, eighth day, fifteen day (kept for one week without treatment) and sixteenth day. The antagonists (40 mg/kg body weight) were also applied simultaneously except in third group animals where these agents were administered from 8th-14th days. Study reveals progressive decreased activity of the enzyme in all the animal groups with increasing the duration of the dose except two days treated animals. NAHT restored the enzyme level in all the groups except in fifteen days MMC treated animals, while DSA was less effective in all the groups except in two days MMC treated animals. The significance of inhibition of the enzyme in relation to methylmercury toxication has been discussed in detail.
D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008767:Methylmercury Compounds / Q000037:antagonists & inhibitors / Q000506:poisoning*; D051381:Rats; D004113:Succimer / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*; D014278:Trigeminal Nuclei / Q000187:drug effects / Q000201:enzymology
D008767:Methylmercury Compounds; D013438:Sulfhydryl Compounds; D013876:Thiophenes; C000486:citiolone; D004113:Succimer; D000469:Alkaline Phosphatase; C004925:methylmercuric chloride