Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing.
The posttranscriptional regulator (p27x-III) of human T cell leukemia virus type I (HTLV-I) is located predominantly in the cell nucleolus. A highly basic amino-terminal sequence (NH2-Met-Pro-Lys-Thr-Arg-Arg-Arg-Pro-Arg-Arg-Ser-Gln-Arg-Lys-Arg-Pro-Pro -Thr- Pro) in this protein, when fused to the amino termini of beta-galactosidase and p40x of HTLV-I, acts as an autonomous signal capable of directing the hybrid proteins to the cell nucleolus.
D000595:Amino Acid Sequence; D002460:Cell Line; D002466:Cell Nucleolus / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009710:Nucleotide Mapping; D012367:RNA, Viral / Q000378:metabolism*; D012191:Retroviridae Proteins / Q000032:analysis* / Q000502:physiology; D015682:Retroviridae Proteins, Oncogenic; D014616:Vaccinia virus
D012367:RNA, Viral; D012191:Retroviridae Proteins; D015682:Retroviridae Proteins, Oncogenic; C052621:px27 protein, human T cell leukemia virus type I