Cerebellar Na+,K+-ATPase activity is increased during early postnatal development of the estrogenized female rat.
The activities of Na+,K+-ATPase and Mg2+-ATPase were measured in the crude P2 synaptosomal fraction of the cerebellum through age 35 days in female rats injected s.c. with 500 micrograms estradiol benzoate 24 h after birth. Estrogenization did not affect Mg2+-ATPase. However, the activity of Na+,K+-ATPase was significantly increased above control values between ages 5 and 20 days. These data demonstrate an age-dependent estrogen-induced effect on cerebellar Na+,K+-ATPase during early postnatal development.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D002531:Cerebellum / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013574:Synaptosomes / Q000187:drug effects / Q000201:enzymology
D004958:Estradiol; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase