Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by ascorbic acid. Implications for antioxidant protection in the inflamed rheumatoid joint.
Ascorbic acid, at physiological concentrations, can scavenge the myeloperoxidase-derived oxidant hypochlorous acid at rates sufficient to protect alpha 1-antiprotease against inactivation by this molecule. The rapid depletion of ascorbic acid at sites of inflammation, as in the inflamed rheumatoid joint, may therefore facilitate proteolytic damage.
D000975:Antioxidants / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D006878:Hydroxides; D017665:Hydroxyl Radical; D006997:Hypochlorous Acid / Q000378:metabolism*; D010084:Oxidation-Reduction; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D009195:Peroxidase / Q000378:metabolism*; D000515:alpha 1-Antitrypsin / Q000037:antagonists & inhibitors
D000975:Antioxidants; D006878:Hydroxides; D000515:alpha 1-Antitrypsin; D017665:Hydroxyl Radical; D006997:Hypochlorous Acid; D009195:Peroxidase; D010196:Pancreatic Elastase; D001205:Ascorbic Acid