Quantitative structure-activity relationship study on hexestrol and metahexestrol derivatives interacting with estrogen receptors.
The estrogen receptor binding affinity of various hexesterol derivatives is found to be significantly related with van der Waals volume of substituents and the Hammett constant sigma. This led to suggest that substituents produce steric effects on the drug-receptor interaction and that the electron-donating capability of substituents enhances the activity. In case of metahexestrol derivatives these factors were however not found to affect the binding affinity of compounds. The reason thereof is discussed.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006589:Hexestrol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011960:Receptors, Estrogen / Q000187:drug effects*; D013329:Structure-Activity Relationship
D011960:Receptors, Estrogen; D006589:Hexestrol; C033293:NSC 297170