[Activity of cell enzymes during treatment of bronchial asthma patients with euphylline and hydrocortisone].
Two groups of patients with bronchial asthma (of average severity and a severe course) and a group of healthy persons were examined. Changes in dehydrogenase activity in the time course of asthma development associated with the depletion of the adaptation mechanisms, and the compensation of these disorders as a result of glucocorticosteroid therapy were established. AP activity in neutrophils could serve as an informative sign indicative of asthma progression and showing the efficacy of hormonotherapy. Various shifts in the metabolic activity of enzymes ensuring the efficacy of phagocytosis with relation to a degree of asthmatic symptoms and therapeutic modalities were revealed.
D000135:Acid Phosphatase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000628:Aminophylline / Q000627:therapeutic use*; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D003402:Creatine Kinase / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D008214:Lymphocytes / Q000201:enzymology*; D009504:Neutrophils / Q000201:enzymology*; D010088:Oxidoreductases / Q000097:blood; D009195:Peroxidase / Q000097:blood; D011494:Protein Kinases / Q000097:blood
D000628:Aminophylline; D010088:Oxidoreductases; D009195:Peroxidase; D011494:Protein Kinases; D003402:Creatine Kinase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D006854:Hydrocortisone
Aktivnost' kletochnykh feremtnov na fone lecheniia bol'nykh bronkhial'noĭ astmoĭ éufillinom i gidrokortizonom.