title: [Multiple sclerosis associated with myasthenia].
abstract: Two patients with a rare combination of generalized myasthenia (M) and multiple sclerosis (MS) have been studied. The development of both diseases in the same patient, despite the rarity of such reports in the world literature, does not appear accidental and may be due to the common nature of pathogenetic mechanisms. The authors believe that the fundamental homogeneity of the diseases lies in impairment of immunological homeostasis characteristic of both autoimmune diseases. Myasthenic manifestations in MS may widely vary from mild subclinical forms of impairment of neuromuscular conductivity to severe generalized forms of M. The authors discuss possible mechanisms of blockage of the neuromuscular conductivity in cases of association of the above nosological entities.
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D009157:Myasthenia Gravis / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D009469:Neuromuscular Junction / Q000502:physiology; D009435:Synaptic Transmission
vernacular_title: O sochetanii rasseiannogo skleroza i miastenii.