[The sympatho-adrenal system. Implications for the pathogenesis, diagnosis and therapy of cardiac arrhythmias].
Changes in biosynthesis, storage, release and inactivation of the catecholamines noradrenaline and adrenaline, as well as in the dynamic regulation and localization (internalization/externalization) of post- and presynaptic alpha- and beta-receptors and their subpopulations have implications for the pathogenesis of cardiac arrhythmias. Circulating levels of plasma catecholamines provide a reliable biochemical index for sympatho-adrenal activity and reactivity as well as for diagnosis and prognosis of these arrhythmias. Therapeutic interventions should consequently prefer blockade of myocardial alpha- and/or beta-adrenoceptors, especially after postischaemic arrhythmias with externalization of beta-adrenoceptors.
D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000503:physiopathology*; D002304:Cardiac Pacing, Artificial; D003327:Coronary Disease / Q000503:physiopathology; D004837:Epinephrine / Q000502:physiology*; D006329:Heart Conduction System / Q000503:physiopathology; D006339:Heart Rate; D006801:Humans; D009638:Norepinephrine / Q000502:physiology*; D011379:Prognosis; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D009638:Norepinephrine; D004837:Epinephrine
Uber das sympathoadrenale System. Implikationen zur Pathogenese, Diagnose und Therapie kardialer Arrhythmien.