title: [Maturation of mammalian bone minerals. A new method for determining bone metabolism].
abstract: The present report begins by comparing data on bone mineralization communicated in the literature to date with the authors' own previously published concept of the "three-phase model". The age-dependent accumulation of minerals in the femurs of Wistar rats was also chemically-analytically investigated. The results suggest that the mineral first formed is octacalcium phosphate. It is followed by sodium- and magnesium-containing phases. Maturation of octacalcium phosphate only occurs after this; it is converted into a highly carbon-deficient hydroxyapatite. During this conversion the molar Ca/P ratio rises from 1.33 to 2. However, the final value of 2 is not fully attained: this is attributable to the "turnover" activity of bone-metabolic processes. The paper concludes with a discussion of how the newly developed chemical method of determining bone turnover can be used to determine its vitality.
mesh_terms: D000818:Animals; D001846:Bone Development; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D011756:Diphosphates / Q000378:metabolism; D005260:Female; D005269:Femur / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D008297:Male; D008903:Minerals / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism
chemical_list: D011756:Diphosphates; D008903:Minerals; D010710:Phosphates; D012964:Sodium; D008274:Magnesium; D002118:Calcium
vernacular_title: Eine Studie über die Reifung von Säugetier-knochenmineralien. Eine neue Methode zur Bestimmung des Knochenumsatzes.