title: Syringocystadenoma papilliferum developed from giant comedo: a case report.
abstract: A case of syringocystadenoma papilliferum in a 44-year-old Japanese male provided interesting clinical and histological findings. The lesion was diagnosed clinically as an infectious when on the flexor aspect of the right thigh. Optical microscopical examination of serial sections showed that the tumor parenchyma was deeply seated along the boundary zone between the cutis and subcutis around the lower half of a giant comedo, and extended into the surrounding tissues from the non-keratinized epithelial portion of the giant comedo where the non-keratinized epithelium merged with the upper, keratinized epithelium. The tumor thus appeared to have developed from the non-keratinized transitional epithelium corresponding to the intrafollicular part of the apocrine sweat gland apparatus. Although 103 cases of syringocystadenoma papilliferum have been reported from Japan since 1924, the present findings are both clinically and histologically unique.
mesh_terms: D000152:Acne Vulgaris / Q000150:complications*; D006607:Adenoma, Sweat Gland / Q000150:complications* / Q000473:pathology; D000328:Adult; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology; D013848:Thigh