Cytoplasmic crystalline inclusions in hepatocytes of a steer with shipping fever.
Needle-shaped crystalline inclusion bodies were found in vacuolated liver cells of a steer affected with pneumonic pasteurellosis. The inclusions were eosinophilic and refractive, and ranged in size from 3 to 6 microns long and from 150 to 250 nm wide. Histochemical examination revealed that they contained lipid and protein. Electron microscopic examination showed finely fibrillar or granular material. Cross-striations with a periodicity of 45 nm were seen in longitudinal section of the inclusions. The possible origin and pathogenic significance of the inclusions are discussed.
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases; D003460:Crystallization; D006651:Histocytochemistry; D002479:Inclusion Bodies / Q000032:analysis / Q000648:ultrastructure*; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D010326:Pasteurella Infections / Q000473:pathology* / Q000662:veterinary*; D012766:Pasteurellosis, Pneumonic / Q000473:pathology*; D011506:Proteins / Q000032:analysis; D014617:Vacuoles / Q000648:ultrastructure
D008055:Lipids; D011506:Proteins