Ocular pathogenicity of herpes simplex virus.
As a relatively small, discrete organ that contains a number of widely different cell types the eye provides an intriguing system in which to study fundamental aspects of virus/cell interactions. Such aspects are considered with particular reference to herpes simplex virus and the pivotal role of virus/neuron interactions in the development of ocular disease. Three aspects of this interaction are discussed: the entry of virus into the eye latency in the trigeminal ganglion nerve damage.
D000818:Animals; D003315:Cornea / Q000294:innervation / Q000503:physiopathology; D003588:Cytopathogenic Effect, Viral; D005123:Eye / Q000382:microbiology*; D005724:Ganglia / Q000503:physiopathology; D007635:Keratitis, Dendritic / Q000382:microbiology* / Q000503:physiopathology; D051379:Mice; D009474:Neurons / Q000382:microbiology; D011930:Reaction Time; D018139:Simplexvirus / Q000472:pathogenicity*; D014276:Trigeminal Nerve / Q000503:physiopathology