Modulation of eicosanoid production due to mast cell-macrophage interaction.
The experiments discussed above demonstrate that macrophages and possibly PMN modulate and contribute to immediate hypersensitivity reactions. Antigen stimulation of sensitized mast cells in vitro in the presence of macrophages showed that the latter contribute prostaglandins and modulate the 5-lipoxygenase products. Early in the time course, 5-lipoxygenase products, including leukotrienes, were enhanced and later decreased. The decrease appeared to be due to active oxygen species and may serve as a negative feedback mechanism to maintain relative homeostasis.
D000707:Anaphylaxis / Q000503:physiopathology; D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D002450:Cell Communication; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis*; D006969:Hypersensitivity, Immediate; D007975:Leukotriene B4 / Q000096:biosynthesis; D008264:Macrophages / Q000502:physiology*; D008407:Mast Cells / Q000502:physiology*; D011453:Prostaglandins / Q000096:biosynthesis; D013189:SRS-A / Q000096:biosynthesis; D013929:Thromboxane B2 / Q000096:biosynthesis
D005231:Fatty Acids, Unsaturated; D011453:Prostaglandins; D013189:SRS-A; D007975:Leukotriene B4; D013929:Thromboxane B2; D001094:Arachidonate 5-Lipoxygenase