title: [Gyrase inhibitor in the local treatment of the chronically infected middle ear following surgery].
abstract: Local treatment of 20 chronic bacterial ear infections (18 infected radical cavities, 2 external otitis) with a gyrase inhibitor (Ciprofloxacin) solution led to clinical resolution in 17 cases, with elimination of the causative organisms in 16 cases. No side effects were seen, but a resistant pseudomonas developed in one case, and candida albicans in 8 others. Gyrase inhibitors such as Ciprofloxacin are antibiotics of second choice. For local treatment in the ear they should be used only in difficult cases and exclusively by the otologist. This treatment must not be used to replace proper cleaning of the ear or a necessary operation.
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D004351:Drug Resistance; D004927:Escherichia coli Infections / Q000188:drug therapy; D006801:Humans; D008297:Male; D010033:Otitis Media / Q000188:drug therapy*; D011512:Proteus Infections / Q000188:drug therapy; D011552:Pseudomonas Infections / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy; D013530:Surgical Wound Infection / Q000188:drug therapy*; D059005:Topoisomerase II Inhibitors
chemical_list: D059005:Topoisomerase II Inhibitors; D002939:Ciprofloxacin
vernacular_title: Gyrasehemmer in der Lokalbehandlung von mit Problemkeimen chronisch infizierten Mittelohroperationshöhlen.