Monooctanoin-associated pulmonary edema.
Monooctanoin is a cholesterol solvent indicated for dissolution of retained biliary stones. We summarize four reports--one from the U.S. Food and Drug Administration's Spontaneous Reporting System for Adverse Drug Reactions and three from published medical literature--of noncardiogenic pulmonary edema during intrabiliary monooctanoin in the United States. Based on these data, we show that pulmonary edema during intrabiliary monooctanoin infusion may occur in approximately one per 1000 patients treated.
D000328:Adult; D002210:Caprylates; D002769:Cholelithiasis / Q000628:therapy; D005989:Glycerides / Q000009:adverse effects*; D006801:Humans; D011654:Pulmonary Edema / Q000139:chemically induced*; D012997:Solvents / Q000009:adverse effects
D002210:Caprylates; D005989:Glycerides; D012997:Solvents; C025343:monooctanoin