title: Fundamental relationships for the effect of proton dissociation equilibria on enzymic reaction steps.
abstract: Relationships have been derived which describe the pH dependence contributed to rate and equilibrium constants for an arbitrary enzymic reaction step by the ionization of an enzymic group or non-enzymic reactant when both protonation states of the ionizing species are assumed to participate in the catalytic reaction.
mesh_terms: D004798:Enzymes / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007477:Ions; D007700:Kinetics; D008433:Mathematics; D008956:Models, Chemical; D011522:Protons
chemical_list: D004798:Enzymes; D007477:Ions; D011522:Protons