Induction by fibroblast growth factor of angiotensin converting enzyme in vascular endothelial cells in vitro.
Induction of vascular endothelial cells with pituitary fibroblast growth factor (FGF) provoked an increase in angiotensin converting enzyme activity. The stimulatory effect of FGF on ACE activity was dose-dependent (ED50 = 1.0 ng/ml). Our results suggest a possible role for pituitary FGF in regulation of ACE production in vascular endothelial cells.
D000803:Angiotensin I / Q000378:metabolism; D000804:Angiotensin II / Q000032:analysis; D000818:Animals; D001011:Aorta; D002216:Captopril / Q000494:pharmacology; D002478:Cells, Cultured; D004492:Edetic Acid / Q000494:pharmacology; D004727:Endothelium / Q000187:drug effects / Q000201:enzymology*; D004790:Enzyme Induction; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D006133:Growth Substances / Q000494:pharmacology; D007700:Kinetics; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis*; D013552:Swine
D006133:Growth Substances; D000804:Angiotensin II; D005346:Fibroblast Growth Factors; D000803:Angiotensin I; D004492:Edetic Acid; D002216:Captopril; D007703:Peptidyl-Dipeptidase A