Inhibition of human neutrophil collagenase by gold(I) salts used in chrysotherapy.
Six gold(I) salts, some of which are used as drugs in chrysotherapy, are shown to be inhibitors of two forms of human neutrophil collagenase. The IC50 values vary over six orders of magnitude, the lowest being 3.5 nM for Myocrisin. Thus, inhibition is greatly affected by the identity of the ligands to the gold(I) atom. The inhibition of collagenase by these gold(I) salts may be a partial basis for their antiarthritic action.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001310:Auranofin / Q000494:pharmacology; D006051:Aurothioglucose / Q000494:pharmacology; D002729:Chloromercuribenzoates / Q000494:pharmacology; D006046:Gold / Q000494:pharmacology*; D006052:Gold Sodium Thiomalate / Q000494:pharmacology; D012971:Gold Sodium Thiosulfate / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors*; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology; D050607:Organogold Compounds; D009942:Organometallic Compounds / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010720:Phosphines; D020245:p-Chloromercuribenzoic Acid
D002729:Chloromercuribenzoates; D050607:Organogold Compounds; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D010720:Phosphines; D006052:Gold Sodium Thiomalate; D006051:Aurothioglucose; D001310:Auranofin; C016797:triethyl phosphine gold; D020245:p-Chloromercuribenzoic Acid; C020868:bis(triethylphosphine)gold chloride; D006046:Gold; D012971:Gold Sodium Thiosulfate; D003012:Microbial Collagenase