Evaluation of coagulation factor abnormalities in long-acting anticoagulant overdose.
Newer Rodenticides of the long-acting anticoagulant or "superwarfarin" class are gaining popularity. Since few cases of severe, prolonged anticoagulation after ingestion have been reported, the course of toxicity is not precisely understood. In this case of an intentional ingestion of brodifacoum, a longitudinal analysis of specific coagulation factor derangements was carried out in an attempt to guide a future treatment strategy for this type of toxicity. Results of this analysis demonstrated a profound decrease in levels of factors II, VII, IX, and X, lasting at least 43 days post ingestion. Treatment with subcutaneous vitamin K1 in doses up to 100 milligrams per day was without complication and was effective in reversing the coagulopathy produced by brodifacoum.
D015110:4-Hydroxycoumarins / Q000506:poisoning*; D000328:Adult; D001779:Blood Coagulation Factors / Q000032:analysis / Q000187:drug effects*; D003692:Delayed-Action Preparations; D006801:Humans; D008297:Male; D011517:Prothrombin Time; D012378:Rodenticides / Q000506:poisoning*; D010837:Vitamin K 1 / Q000627:therapeutic use
D015110:4-Hydroxycoumarins; D001779:Blood Coagulation Factors; D003692:Delayed-Action Preparations; D012378:Rodenticides; D010837:Vitamin K 1; C013418:bromfenacoum