Multi-system coxsackievirus B-6 infection with findings suggestive of diabetes mellitus.
A fatal case of Coxsackievirus B-6 (CBV-6) infection in a 4 1/2-year-old girl is reported. The disease was initially characterized by a severe meningoencephalitis and, successively, by the appearance of hyperglycaemia and glycosuria, concomitantly with complement-fixing-islet cell antibodies (CF-ICA) and ICA, diarrhoea, electrolyte disorders, arrhythmia and decrease of the IgG levels, suggesting a multi-system involvement. CBV-6 was identified by isolation from stool and cerebrospinal fluid and by detection of specific IgM antibodies.
D002675:Child, Preschool; D003384:Coxsackievirus Infections / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000276:immunology; D029822:Enterovirus B, Human / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008590:Meningoencephalitis / Q000150:complications* / Q000276:immunology / Q000382:microbiology