Interleukin-2 binding to activated human T lymphocytes triggers generation of cyclic AMP but not of inositol phosphates.
Human T lymphocytes stimulated with phytohaemagglutinin undergo a single round of cell division. Further proliferation is dependent on the lymphokine interleukin-2 (IL2) [(1987) Immunology 60, 7-12]. We show here that binding of IL2 to its receptors on the lymphocyte surface triggers the generation of cyclic AMP. In contrast, generation of inositol phosphates from the breakdown of inositol lipids was not detected. We suggest that cyclic AMP may play a role in the transduction of the IL2 proliferative signal in T lymphocytes.
D001665:Binding Sites; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D007295:Inositol Phosphates / Q000378:metabolism*; D007376:Interleukin-2 / Q000502:physiology*; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology; D013403:Sugar Phosphates / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*
D007295:Inositol Phosphates; D007376:Interleukin-2; D010835:Phytohemagglutinins; D013403:Sugar Phosphates; D000242:Cyclic AMP