title: Effects of kanamycin administration to poultry on the proliferation of drug-resistant Salmonella.
abstract: Four experiments were conducted to examine the relationship between antibiotic administration to poultry and the in vivo proliferation of Salmonellae. The frequency of isolation of drug-resistant transconjugant S. arizonae from the livers of chicks inoculated per os with multiply drug-resistant Escherichia coli and drug-sensitive S. arizonae was directly related to the concentration of kanamycin administered to the chicks in their drinking water. Kanamycin administration was also associated with a significant (P less than .05) increase in the frequency of isolation of drug-resistant transconjugant S. typhimurium from the intestines and livers of poults inoculated with drug-sensitive S. typhimurium and multiply drug-resistant E. coli. Kanamycin administration significantly reduced the spread of drug-sensitive S. typhimurium to the livers of poults inoculated only with that strain. These experiments demonstrate that antibiotic administration to poultry can enhance the proliferation of drug-resistant Salmonella.
mesh_terms: D000821:Animal Feed; D000818:Animals; D002645:Chickens / Q000382:microbiology*; D004926:Escherichia coli / Q000187:drug effects*; D005503:Food Additives; D007422:Intestines / Q000382:microbiology; D007612:Kanamycin / Q000008:administration & dosage / Q000494:pharmacology; D007613:Kanamycin Resistance; D008099:Liver / Q000382:microbiology; D012475:Salmonella / Q000187:drug effects*; D012476:Salmonella arizonae / Q000187:drug effects*; D012486:Salmonella typhimurium / Q000187:drug effects*; D014422:Turkeys / Q000382:microbiology*
chemical_list: D005503:Food Additives; D007612:Kanamycin