title: Fluctuating PEEP versus conventional PEEP in diffuse and unilateral lung injury induced by oleic acid.
abstract: Effects of fluctuating positive end-expiratory pressure (F-PEEP), in which end-expiratory pressure (EEP) was periodically changed from 0.5 to 1.5 kPa with a periodic time of 6 min, and conventional PEEP (C-PEEP) with a fixed EEP of 1.0 kPa, were comparatively studied in diffuse (Group I) and unilaterally dominant lung injury (Group II). Although F-PEEP produced cyclic alterations of PaO2 in both groups, PaO2 changed in proportion to EEP in Group I and in reciprocal proportion to EEP in Group II. There was no significant difference between PaO2 and QS/QT during F-PEEP and those during C-PEEP in Group I, whereas in Group II, F-PEEP produced a significantly greater improvement of pulmonary oxygenation at the low EEP phase than C-PEEP. In both groups, the degree of hemodynamic depression was proportional to EEP. These results suggest that F-PEEP should be indicated for acute hypoxic respiratory failure with uneven distribution of lung injury.
mesh_terms: D000818:Animals; D002057:Burns, Chemical / Q000503:physiopathology / Q000628:therapy*; D004285:Dogs; D006439:Hemodynamics; D007384:Intermittent Positive-Pressure Breathing; D008168:Lung / Q000503:physiopathology; D055370:Lung Injury; D019301:Oleic Acid; D009829:Oleic Acids; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011175:Positive-Pressure Respiration / Q000379:methods*; D011659:Pulmonary Gas Exchange
chemical_list: D009829:Oleic Acids; D019301:Oleic Acid; D010100:Oxygen