Susceptibility of HSV strains from patients with genital herpes treated with various formulations of acyclovir.
Virus isolates from 55 patients with recurrent or first-episode genital herpes, treated with various formulation of acyclovir, were tested for their susceptibility to the drug. In all but one of these patients pre-treatment isolates were available for comparison with later isolates. In none of patients, even those receiving long-term prophylaxis, was the susceptibility of the post-treatment isolates significantly reduced.
D000212:Acyclovir / Q000008:administration & dosage* / Q000494:pharmacology; D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D006558:Herpes Genitalis / Q000188:drug therapy*; D006801:Humans; D012008:Recurrence; D018139:Simplexvirus / Q000187:drug effects*; D014709:Vero Cells; D010948:Viral Plaque Assay
D000212:Acyclovir