Potency stability of recombinant (Serine-17) human interferon-beta.
The antiviral activity of Escherichia coli-derived (Serine-17) human interferon-beta, formulated with human serum albumin, is stable for 2 years when lyophilized and stored under refrigeration. This product shows an Arrhenius line fit for the stability of its activity when tested at multiple isothermal temperatures (25-80 degrees C). In both isothermal and nonisothermal elevated temperature studies, increasing the level of human serum albumin in the formulation results in increased thermal stability.
D002460:Cell Line; D004355:Drug Stability; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D007370:Interferon Type I / Q000235:genetics / Q000494:pharmacology*; D000068556:Interferon beta-1a; D000068576:Interferon beta-1b; D016899:Interferon-beta; D011994:Recombinant Proteins / Q000494:pharmacology*; D013816:Thermodynamics; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects*
D007370:Interferon Type I; D011994:Recombinant Proteins; D000068576:Interferon beta-1b; D016899:Interferon-beta; D000068556:Interferon beta-1a