title: Inhibition of adherence of Candida albicans by conventional and experimental antifungal drugs.
abstract: We tested the effects of antifungal drugs on adherence of Candida albicans in vitro. Significant reduction of adherence occurred after 2 h incubation with amphotericin B, nystatin, miconazole, econazole, ketoconazole, chlorohexidine and ICI 195,739. Significant inhibition of candida adherence by 5-fluorocytosine and amorolfin required 18 h incubation. Combinations of amphotericin B with 5-fluorocytosine, miconazole, ICI 195,739 and amorolfin resulted in synergistic inhibition of adherence. Adherence is an important pathogenic mechanism in candida infections and interference with this process may represent a major component of the mode of action of antifungal drugs.
mesh_terms: D000268:Adhesiveness; D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000502:physiology*; D002710:Chlorhexidine / Q000494:pharmacology; D004338:Drug Combinations; D006801:Humans; D009025:Morpholines / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D009025:Morpholines; D000666:Amphotericin B; C038974:amorolfine; D002710:Chlorhexidine