In vivo 31P NMR spectroscopy of agonist-stimulated phosphatidylinositol metabolism in cat brain.
As a result of the agonist stimulation of muscarinic receptors, myo-inositol-1-phosphate accumulates in the presence of millimolar lithium concentrations. This accumulation of myo-inositol-1-phosphate can be detected by in vivo 31P NMR spectroscopy. Since myo-inositol-1-phosphate is a breakdown product of phosphatidylinositol, this may provide a means of noninvasively monitoring phosphatidylinositol metabolism in vivo.
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D002415:Cats; D002712:Chlorides / Q000494:pharmacology*; D007295:Inositol Phosphates / Q000378:metabolism*; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010862:Pilocarpine / Q000494:pharmacology*; D011976:Receptors, Muscarinic / Q000187:drug effects; D013403:Sugar Phosphates / Q000378:metabolism*
D002712:Chlorides; D007295:Inositol Phosphates; D011976:Receptors, Muscarinic; D013403:Sugar Phosphates; D010862:Pilocarpine; C002647:inositol 1-phosphate; D008094:Lithium; D018021:Lithium Chloride