Induction in human allograft recipients of unresponsiveness to anti-lymphocyte globulin.
The observations presented here confirm previous reports that polyclonal ALG prepared at the University of Minnesota or ATGAM of The Upjohn Co., administered as described, rarely induced sensitization of patients to the horse gamma globulin. In addition, the phenomena of transient antibody production prior to the onset of unresponsiveness and the induction of unresponsiveness in individuals with preexisting antibodies were observed.
D000818:Animals; D000917:Antibody Formation; D000961:Antilymphocyte Serum / Q000276:immunology* / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D006085:Graft Survival; D006736:Horses; D006801:Humans; D007108:Immune Tolerance; D016030:Kidney Transplantation; D014181:Transplantation Immunology
D000961:Antilymphocyte Serum