Noradrenaline inhibits vasoconstriction induced by electrical stimulation.
Exposure of the isolated rat tail artery to exogenous noradrenaline inhibited vasoconstriction induced by electrical field stimulation. Phenylephrine produced brief inhibition; guanfacine potentiated electrical stimulation. Sympathetic neurotransmission may be blunted by brief increases in circulating noradrenaline levels.
D000818:Animals; D001158:Arteries / Q000187:drug effects; D004558:Electric Stimulation; D016316:Guanfacine; D006146:Guanidines / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000378:metabolism / Q000494:pharmacology*; D010648:Phenylacetates / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
D006146:Guanidines; D010648:Phenylacetates; D010656:Phenylephrine; D016316:Guanfacine; D012110:Reserpine; D009638:Norepinephrine