[Chloroquine neuromyopathies: 4 cases during antimalarial prevention].
Four cases of chloroquine neuropathy presented two points of particular interest: 1) these were all young women with strictly prophylactic doses of chloroquine (100 mg/24 h); two patients showed pronounced loss of weight; 2) signs of myogenic lesions were apparent in only one patient whereas clinical and electric signs of neurogenic involvement were observed in all 4 cases. Biopsy in 3 patients (muscle in one and muscle and nerve in two) failed to show characteristic vacuoles; in one case mild segmental demyelinization was present. A favorable course was obtained in all cases after discontinuation of chloroquine, with dramatic recovery from the motor deficit. Pharmacokinetic studies in 1 patient showed abnormally high chloroquine levels at initial assay with slow elimination after its discontinuation.
D000328:Adult; D002738:Chloroquine / Q000009:adverse effects*; D006801:Humans; D006987:Hypesthesia / Q000139:chemically induced; D002479:Inclusion Bodies / Q000648:ultrastructure; D008854:Microscopy, Electron; D009069:Movement Disorders / Q000139:chemically induced; D009132:Muscles / Q000473:pathology*; D009135:Muscular Diseases / Q000139:chemically induced* / Q000473:pathology; D010525:Peripheral Nerves / Q000473:pathology*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*
D002738:Chloroquine
Neuromyopathies à la chloroquine: 4 cas au cours d'une prophylaxie anti-paludéenne.