[Ability of cholestyramine to bind Escherichia coli and Vibrio cholerae toxins].
Cholestyramine treatment of new born's infectious diarrhea has been shown to be effective. The study of in vitro binding of bacterial toxins from Vibrio Cholerae and from three strains of Escherichia coli suggest an ionic adsorption of the four toxins to this anion-exchange resin. This immediate binding is effective at the pH of intestinal fluid, therefore the protection of the enterocytes from the biological action of the toxins result of the toxins sequestering effect of the Cholestyramine.
D000327:Adsorption; D000818:Animals; D001427:Bacterial Toxins / Q000378:metabolism*; D002478:Cells, Cultured; D002792:Cholestyramine Resin; D003603:Cytotoxins / Q000378:metabolism; D004926:Escherichia coli; D006863:Hydrogen-Ion Concentration; D051379:Mice; D014734:Vibrio cholerae
D001427:Bacterial Toxins; D003603:Cytotoxins; D002792:Cholestyramine Resin
Etude de l'aptitude de la cholestyramine à fixer les toxines d'Escherichia coli et de Vibrio cholerae.