title: [Inactivation of formaldehyde by semicarbazide in disinfectant tests with viruses].
abstract: In suspension tests with viruses formaldehyde is--even in weak concentrations--toxic for tissue cultures. Through addition of semicarbazide in a ratio of one part of 10% semicarbazide to one part of 0.7% formaldehyde, which is equivalent to a molar ratio of 3.8:1, the toxicity will be neutralized if semicarbazide is added to the tissue cultures before their being inoculated with the virus-disinfectant-mixture. In qualitative experiments the toxicity is completely neutralized, in quantitative ones it is reduced by a factor of 10 up to 100. Thus the evaluation of the virucidal capacity of disinfectants containing formaldehyde is conspicuously improved.
mesh_terms: D000256:Adenoviridae / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003588:Cytopathogenic Effect, Viral; D004202:Disinfectants / Q000494:pharmacology*; D005557:Formaldehyde / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D017955:Poliovirus / Q000187:drug effects; D012663:Semicarbazides / Q000494:pharmacology*; D014616:Vaccinia virus / Q000187:drug effects; D014780:Viruses / Q000187:drug effects*
chemical_list: D004202:Disinfectants; D012663:Semicarbazides; D005557:Formaldehyde
vernacular_title: Inaktivierung von Formaldehyd durch Semicarbazid bei Desinfektionsmittelversuchen mit Viren.