Neuron-specific enolase-positive rosettes in nephroblastoma: a possible diagnostic pitfall in aspiration cytology.
Neuron-specific enolase-positive cells, some arranged in rosettes, were identified in smears obtained in fine-needle aspiration of a left retroperitoneal tumor found in a 3-yr-old boy. Nephrectomy showed a typical nephroblastoma with a prominent blastemic component revealing a positive reaction for neuron-specific enolase in blastemic and tubular components. Neuron-specific, enolase-positive, small malignant cells are not diagnostic of neuroblastoma when coming from a tumor of the retroperitoneum even if rosettes are present.
D001707:Biopsy, Needle; D002675:Child, Preschool; D003951:Diagnostic Errors; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000201:enzymology; D008297:Male; D009447:Neuroblastoma / Q000175:diagnosis / Q000201:enzymology; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D009396:Wilms Tumor / Q000175:diagnosis* / Q000201:enzymology
D010751:Phosphopyruvate Hydratase