[Delayed development of hypertension and increased aortic relaxation in spontaneously hypertensive rats after neonatal sympathectomy].
The effect of neonatal sympathectomy on vasodilator responses to acetylcholine (ACh) and cAMP has been studied in aortic rings of spontaneously hypertensive rats (SHR) and normotensive animals. The relaxation of intact SHR aorta in response to ACh and cAMP was 20-35% lower than that of normotensive rats. Sympathectomy in normotensive rats did not affect the level of blood pressure and aorta reactivity to Ach. In SHR, sympathectomy caused a decrease in blood pressure, while relaxation in response to ACh and cAMP increased, as compared to intact SHR, but remained lower than in normotensive rats. The data obtained suggest that the decrease in arterial pressure of sympathectomized SHR is a result not only of the reduction in sympathetic effects but also of the increase in smooth muscle relaxation.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D001011:Aorta / Q000187:drug effects / Q000503:physiopathology*; D000242:Cyclic AMP / Q000494:pharmacology; D006145:Guanethidine; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*; D011921:Rats, Inbred WKY; D013563:Sympathectomy, Chemical; D014664:Vasodilation / Q000187:drug effects
D000242:Cyclic AMP; D000109:Acetylcholine; D009638:Norepinephrine; D006145:Guanethidine
Zamedlenie razvitiia gipertenzii i uvelichenie relaksatsii aorty spontanno gipertenzivnykh krys posle neonatal'noĭ simpatéktomii.