Effect of ACTH-(4-10) on Bechterew's compensation in squirrel monkeys.
ACTH-(4-10), a fragment of the ACTH without hormonal action, has been known to have effects on learning and memory process. Recently, we have shown that ACTH-(4-10) had marked effects on the balance compensation process after unilateral labyrinthectomy in squirrel monkeys. In this study, we examined the effect of daily administration of ACTH-(4-10) following two-staged bilateral labyrinthectomy. When the locomotor balance function and the slow-phase eye velocity of the spontaneous nystagmus were analyzed, the ACTH-(4-10) groups compensated significantly faster than the control group (p less than 0.05).
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D007758:Ear, Inner / Q000601:surgery; D005133:Eye Movements / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D009759:Nystagmus, Pathologic / Q000517:prevention & control; D010446:Peptide Fragments / Q000494:pharmacology*; D004856:Postural Balance / Q000187:drug effects; D012453:Saimiri; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10)