An outer membrane protein (porin) as an eliciting antigen for delayed-type hypersensitivity in murine salmonellosis.
The porin, an outer membrane protein of Salmonella typhimurium, was found to be a suitable antigen for eliciting delayed-type hypersensitivity in mouse salmonellosis. Histological examination of the reaction site revealed that the porin was superior to other antigenic preparations in eliciting a typical delayed-type hypersensitivity reaction consisting of mononuclear cell infiltration without polymorphonuclear cell contamination. This study indicates the importance of using a suitable protein antigen from S. typhi for human application.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000209:etiology* / Q000473:pathology; D007249:Inflammation; D051379:Mice; D008807:Mice, Inbred BALB C; D018272:Porins; D012481:Salmonella Infections, Animal / Q000150:complications / Q000276:immunology*; D012486:Salmonella typhimurium / Q000276:immunology
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D018272:Porins