Inhibition of arsenazo III Ca transient with deuterium oxide in frog twitch fibers at a resting sarcomere length.
Arsenazo III calcium transients during twitches of frog skeletal muscle fibers were recorded in H2O Ringer (control) and deuterium oxide Ringer (test). In ten fibers, the amplitude of the test at a sarcomere length of 2.5 microns was reduced to 57% of the control and accompanied by extremely diminished tension responses. The latency was also increased to 158%.
D000818:Animals; D001150:Arsenazo III / Q000378:metabolism*; D001391:Azo Compounds / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D003903:Deuterium / Q000494:pharmacology*; D017666:Deuterium Oxide; D009119:Muscle Contraction / Q000187:drug effects; D009210:Myofibrils / Q000187:drug effects*; D011898:Ranidae; D012518:Sarcomeres / Q000187:drug effects* / Q000378:metabolism; D014867:Water / Q000494:pharmacology*
D001391:Azo Compounds; D014867:Water; D001150:Arsenazo III; D003903:Deuterium; D017666:Deuterium Oxide; D002118:Calcium