title: [In vitro systems for the primary search for biologically active substances with carcinostatic action].
abstract: Improvement and development of new methods for primary screening of antitumour drugs in vitro are based on the data on the points open to injury in the tumour cell metabolism and on the evidence of the known carcinostatic drug mechanism. Further development of the primary screening methods should proceed, probably, in two main directions. Further improvement of the methods for cloning tumour cells in the semifluid nutrient media is of great interest. On the whole the creation of new test systems is a significant trend of the scientific screening.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D002999:Clone Cells / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Sistemy in vitro dlia pervichnogo poiska biologicheski aktivnykh veshchestv s kantserostaticheskim deĭstviem.