Neuropeptides and leukotriene release: effect of peptide histidine isoleucine and secretin in platelet activating factor-stimulated rat lung.
We have previously demonstrated that vasoactive intestinal peptide and calcitonin gene-related peptide inhibit leukotriene release from platelet activating factor-stimulated rat lung. We now report evidence that Peptide Histidine Isoleucine and Secretin, two naturally occurring peptides which are structurally homologous to vasoactive intestinal peptide, show a significant ability to inhibit leukotriene release in the same animal model. A preliminary hypothesis about the mechanism of this inhibition by the neuropeptides is discussed.
D000818:Animals; D066298:In Vitro Techniques; D017999:Leukotriene E4; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010451:Peptide PHI / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D013189:SRS-A / Q000031:analogs & derivatives / Q000378:metabolism*; D012633:Secretin / Q000494:pharmacology*
D010451:Peptide PHI; D010972:Platelet Activating Factor; D013189:SRS-A; D012633:Secretin; D017999:Leukotriene E4