title: Ofloxacin in the treatment of urinary tract infection in renal transplant recipients.
abstract: Forty-two renal transplant recipients suffering from complicated urinary tract infection (UTI) were treated orally with ofloxacin. Patients received an immunosuppressive treatment consisting of ciclosporin A and prednisolone (n = 39) or azathioprine and prednisolone (n = 3). Patients were routinely controlled for laboratory parameters before, during and after ofloxacin administration with special emphasis on nephrotoxicity and interaction of ofloxacin with the concomitantly administered immunosuppressives. Results show that ofloxacin does not impair renal graft function or interact with ciclosporin A or azathioprine even under long-term administration. It is effective and safe in the treatment of UTI in the renal transplant recipient.
mesh_terms: D000328:Adult; D000368:Aged; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin; D010078:Oxazines / Q000009:adverse effects / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D007166:Immunosuppressive Agents; D010078:Oxazines; D015242:Ofloxacin