title: A40926 aglycone and pseudoaglycones: preparation and biological activity.
abstract: A40926 antibiotics are new glycopeptides which are much more active than other members of this class against Neisseria gonorrhoeae. Their activity against Gram-positive bacteria, including coagulase-negative Staphylococci, is similar to that of other glycopeptides. An A40926 preparation containing factors A and B ("A40926 A + B complex") was hydrolyzed to the aglycone and to the mannosyl and N-acylaminoglucuronyl aglycones. The mannosyl aglycone and the aglycone were less active than A40926 A + B complex against Streptococci and Gram-positive anaerobes and lost the anti-gonorrheal activity. In contrast, the N-acylaminoglucuronyl aglycones were as active as the parent complex against these Gram-positive bacteria and were moderately active against N. gonorrhoeae. The aglycone and, even more so, the N-acylaminoglucuronyl aglycones, had better activity than the parent complex against coagulase-negative Staphylococci. In experimental septicemia in the mouse, A40926 A + B complex and its derivatives had activity proportional to their MIC for the test organism.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D002846:Chromatography, Affinity; D002851:Chromatography, High Pressure Liquid; D006020:Glycopeptides / Q000302:isolation & purification / Q000494:pharmacology; D006868:Hydrolysis; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009343:Neisseria / Q000187:drug effects; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology; D010456:Peptides, Cyclic; D013210:Staphylococcus / Q000187:drug effects; D013290:Streptococcal Infections / Q000188:drug therapy; D013291:Streptococcus / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects; D017334:Teicoplanin / Q000031:analogs & derivatives
chemical_list: C054981:A 40926; D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D010455:Peptides; D010456:Peptides, Cyclic; C057568:A 40926 aglycone; D017334:Teicoplanin