title: Instrumental variables in the evaluation of diagnostic test procedures when the true disease state is unknown.
abstract: We explore the estimation of sensitivity and specificity of diagnostic tests when the true disease state is unknown. Instrumental variables which subdivide the patient population are used. A logistic model, relating these instrumental variables to the (unknown) true disease state is proposed. It is shown that this procedure allows the goodness-of-fit to the resulting model to be tested.
mesh_terms: D003622:Dapsone / Q000652:urine; D004797:Enzyme-Linked Immunosorbent Assay; D006386:Hemagglutination Tests; D006801:Humans; D007918:Leprosy / Q000188:drug therapy / Q000652:urine; D010349:Patient Compliance; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D003622:Dapsone