[Endogenous ouabain-like substances in animal tissues].
Methods of purification and properties of the digitalis-like substances from different animal-origin sources are considered. Possible mechanisms of the cardiac glycoside-effect on the cardiac muscle and endogenous digitalis-like factors' effect on the smooth muscles of the blood vessels are discussed. Criteria that may be used to characterize the digitalis-like activity in samples and extracts obtained from different tissues are presented. The role of these substances in some types of pathologies, especially in the development of hypertension, is considered.
D000818:Animals; D002301:Cardiac Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D010042:Ouabain / Q000031:analogs & derivatives / Q000302:isolation & purification* / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D002301:Cardiac Glycosides; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase
Endogennye uabainpodobnye veshchestva v tkaniakh zhivotnykh.