Parkinson's disease and myasthenia gravis: adverse effect of trihexyphenidyl on neuromuscular transmission.
A 55-year-old man with idiopathic Parkinson's disease developed myasthenia gravis shortly after taking trihexyphenidyl. The myasthenic weakness waxed and waned with rise and fall in serum levels of trihexyphenidyl, without marked change of anti-acetylcholine receptor antibody titer.
D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000139:chemically induced* / Q000150:complications; D009469:Neuromuscular Junction / Q000187:drug effects; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy*; D009435:Synaptic Transmission / Q000187:drug effects; D014282:Trihexyphenidyl / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use
D014282:Trihexyphenidyl