[Stimulation of transcription in mouse liver cells by nitrogen oxide free radicals].
The ESR signal of nitrosyl complexes appears in mouse liver after hydroxylamine injection in vivo. This ESR signal testifies to the appearance of NO free radicals. The concomitant accumulation of [3H]uridine in liver RNA evidences for stimulation of transcription. This stimulation is about the same order of magnitude as the stimulation of transcription after gamma-irradiation of mice with lethal doses. It is assumed that NO and, possibly, other oxygen free radicals can disorder the gene expression machinery in the cells.
D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D009589:Nitrogen Oxides / Q000378:metabolism*; D014158:Transcription, Genetic
D005609:Free Radicals; D009589:Nitrogen Oxides
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