Monocyte procoagulant activity as a peripheral marker of clotting activation in cancer patients.
Peripheral blood monocytes generate the procoagulant tissue factor in vitro and in vivo in response to stimulation by a variety of agents. Monocytes from cancer patients generate significantly increased tissue factor and a quantitative relationship exists between the levels of monocyte tissue factor (MTF) and levels of circulating fibrinopeptide A (FPA), a marker of in vivo clotting activation. Furthermore, monocytes from cancer patients have a greater procoagulant response to stimulation by endotoxin in vitro, which appears independent of lymphocyte regulation. These findings suggest a priming process in vivo, and may reflect exposure of monocytes to tumor antigen(s) or components of the immune response to tumors.
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001779:Blood Coagulation Factors / Q000378:metabolism*; D005345:Fibrinopeptide B / Q000032:analysis; D006801:Humans; D009000:Monocytes / Q000378:metabolism*; D009369:Neoplasms / Q000097:blood*; D009374:Neoplasms, Experimental / Q000097:blood; D013925:Thromboplastin / Q000378:metabolism
D000925:Anticoagulants; D001779:Blood Coagulation Factors; C045072:macrophage procoagulant activity; D005345:Fibrinopeptide B; D013925:Thromboplastin