Inhibition of Na,K-ATPase by sodium selenite and reversal by glutathione.
Sodium selenite has been shown to inhibit Na,K-ATPase. Glutathione, at sufficient excess, is able to prevent or reverse the inhibition. Dithiothreitol can also reverse much of the inhibition, but KCN cannot. Selenomethionine does not inhibit Na,K-ATPase. The interactions of sodium selenite with Na,K-ATPase and glutathione may aid in understanding the early events in selenium cataractogenesis.
D000818:Animals; D004285:Dogs; D005978:Glutathione / Q000494:pharmacology*; D020887:Selenious Acid; D012643:Selenium / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000254:Sodium-Potassium-Exchanging ATPase; D020887:Selenious Acid; D005978:Glutathione; D012643:Selenium