Gestational diabetes reverses the circadian variation of plasma insulin response to intravenous glucose.
Both healthy third-trimester pregnant women and a group of women with gestational diabetes failed to show a difference in glucose clearance rates when given an intravenous glucose bolus at 8 AM compared with 4 PM. The plasma insulin response in the healthy pregnant women was greater at 8 AM. In the diabetic group, the peak insulin response was greater at 4 PM, but it was more prolonged after the 8 AM tests. These alterations in plasma insulin response were especially striking in the subgroup of obese women with gestational diabetes, who demonstrated metabolic differences compared with their nonobese counterparts.
D001786:Blood Glucose / Q000032:analysis; D002940:Circadian Rhythm; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood*; D009765:Obesity; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood; D011254:Pregnancy in Diabetics / Q000097:blood*
D001786:Blood Glucose; D007328:Insulin