K-13, a novel inhibitor of angiotensin I converting enzyme produced by Micromonospora halophytica subsp. exilisia. II. Structure determination.
The structure of K-13, a potent inhibitor of angiotensin I converting enzyme (ACE), was determined to be a cyclic dipeptide composed of tyrosine and an unusual diamino dicarboxylic acid, isodityrosine, by spectral and chemical studies of K-13 and its derivatives.
D000806:Angiotensin-Converting Enzyme Inhibitors; D009682:Magnetic Resonance Spectroscopy; D008847:Micromonospora; D010456:Peptides, Cyclic / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D014443:Tyrosine / Q000031:analogs & derivatives / Q000032:analysis
D000806:Angiotensin-Converting Enzyme Inhibitors; D010456:Peptides, Cyclic; C052543:K-13 (ACE inhib); D014443:Tyrosine; C035129:isodityrosine