Inhibition of synaptic transmission in the hippocampus by cholecystokinin (CCK) and its antagonism by a CCK analog (CCK27-33).
The actions of CCK-8 and putative CCK-8 antagonists were examined on synaptic transmission in the hippocampal slice preparation. CCK-8 (10(-7) M) caused a reversible depression of postsynaptic responses of the Schaffer collateral-CA1 synapse. CCK-mediated depression was unaffected by proglumide (10(-3) M) but was antagonized by a CCK analog (CCK27-33). The CCK analog alone had an excitatory effect on synaptic transmission. These results suggest that CCK has an inhibitory action on synaptic transmission.
D000818:Animals; D003864:Depression, Chemical; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology; D011377:Proglumide / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012844:Sincalide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects
D010446:Peptide Fragments; C025997:cholecystokinin (27-33); D011377:Proglumide; D012844:Sincalide