title: [Long-term effects of a combination of transdermal nicotine administration with behavior therapy for smoking cessation].
abstract: Effects of a transdermal nicotine substitution on psychological smoking cessation were investigated in a double-blind prospective study. 131 smokers have been randomly assigned to three treatment conditions: All smokers underwent nine weeks of self-controlled smoking cessation. During 6 weeks one group was additionally treated with nicotine patches continuously releasing nicotine through the skin into the blood circuit. The second group received placebo patches; while the third group was treated with behavioral training alone. Treatment effects were measured by daily cigarette consumption. Follow-up investigations were performed 3, 6 and 12 months after therapy. Nicotine-treated subjects reached significantly higher abstinence rates during and at the end of treatment as well as during the follow-up period, than both placebo- and control-subjects. No severe side effects of plasters have been reported. The results thus indicate good therapeutic effectiveness of transdermal nicotine substitution.
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D001521:Behavior Therapy / Q000379:methods*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009538:Nicotine / Q000008:administration & dosage*; D011897:Random Allocation; D012907:Smoking / Q000628:therapy*
chemical_list: D009538:Nicotine
vernacular_title: Langfristige Effekte einer Kombination von transdermaler Nikotinzufuhr mit Verhaltenstherapie zur Raucherentwöhnung.