title: Exposure to low doses of the environmental chemical dieldrin causes behavioral deficits in animals prevented from coping with stress.
abstract: Experiments were conducted which assessed the effects of low doses of an environmental contaminant in conjunction with various forms of stress. Rats were given acute doses (0, 0.5, 1.5, 4.5 mg/kg) of the chemical dieldrin and subsequently exposed to a series of 40 escapable shocks, identical inescapable shocks, or no shock in an operant chamber. Eight hours later, the subjects were re-exposed in a shuttlebox to footshock which was escapable upon performance of an FR-2 shuttle response. Escape deficits which were related in magnitude to the size of the dieldrin dose were found in the inescapable shock group but not in the escapable shock or no shock groups. The data suggest that experience with the lack of control over stress is critical in determining the behavioral effects of the agent and that the behavioral effects caused by uncontrollable stress may be exacerbated by concurrent exposure to such compounds. These results are discussed in terms of previous studies on the behavioral actions of dieldrin, the response to uncontrollable stress and the common neuronal systems that may be involved.
mesh_terms: D000818:Animals; D004026:Dieldrin / Q000633:toxicity*; D004597:Electroshock; D004924:Escape Reaction / Q000187:drug effects*; D006380:Helplessness, Learned; D008297:Male; D001523:Mental Disorders / Q000209:etiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects; D013312:Stress, Physiological / Q000150:complications*
chemical_list: D011963:Receptors, GABA-A; D004026:Dieldrin