title: Distribution of angiotensin converting enzyme in sheep hypothalamus and medulla oblongata visualized by in vitro autoradiography.
abstract: In vitro autoradiographic mapping of angiotensin converting enzyme (ACE) in sheep brain using the specific ACE inhibitor, 125I-351A, revealed very high densities of binding in large blood vessels and choroid plexus. In the a very high density of labelling occurred in the organum vasculosum of the lamina terminalis and median eminence and a high density in the subfornical organ and moderate density in supraoptic, suprachiasmatic, arcuate and paraventricular nuclei. All fiber tracts were unlabelled. In the medulla oblongata, a very high density of binding was detected in the area postrema and a high density in the nucleus of the solitary tract and dorsal motor nucleus of the vagus; a moderate density was found in the substantia gelatinosa of the spinal tract and the inferior olivary nucleus.
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D001345:Autoradiography; D004656:Enalapril / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D007031:Hypothalamus / Q000201:enzymology*; D007457:Iodine Radioisotopes; D017706:Lisinopril; D008526:Medulla Oblongata / Q000201:enzymology*; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D012756:Sheep
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007457:Iodine Radioisotopes; D004656:Enalapril; D017706:Lisinopril; D007703:Peptidyl-Dipeptidase A