[Interaction of human embryo cells derived from different tissues with lymphoblastoid cell lines].
Cells from skin and muscle of two month human embryo and from nasopharynx, tonsil, lung and kidney of four month human embryo were cocultivated with lymphoblastoid cells--B95-8 and Raji. It is found that all the epithelial cells, such as the focal growth of epithelioid cells from the tonsil and nasopharynx as well as kidney cells from the human embryo can not adhere to any kind of lymphoblastoid cells; but fibroblasts from muscle and skin of two month embryo or from nasopharynx, tonsil and lung of four month embryo have the ability of sticking to lymphoblastoid cells. However, only the fibroblastoid cells from the nasopharynx of human embryo have the ability to stick and to fuse with lymphoblastoid cells--B95-8 in cocultivation and to activate the EBV production. The mechanism of this phenomenon and its biological functions will be studied in detail.
D002448:Cell Adhesion; D002450:Cell Communication; D002459:Cell Fusion; D002460:Cell Line; D004622:Embryo, Mammalian; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D008214:Lymphocytes / Q000166:cytology*; D009305:Nasopharynx / Q000166:cytology*; D014066:Palatine Tonsil / Q000166:cytology; D012867:Skin / Q000166:cytology