Taurine interferes with spiperone binding in the striatum.
The effects of taurine and its structural analogues and two new anticonvulsant derivatives, taltrimide and MY-103, on the function of brain dopaminergic systems were studied by assessing their interference with the binding of [3H]spiperone to synaptic membranes isolated from rat striata. Two populations of binding sites were detected. The binding was effectively displaced by (+)butaclamol and dopamine, serotonin being less potent by one order of magnitude. Taurine, taltrimide and MY-103 inhibited spiperone binding moderately. The binding constants of both high- and low-affinity components and the maximal binding capacity of the low-affinity component decreased in the presence of taurine. The results show that taurine and its novel anticonvulsant derivates could modulate the function of striatal dopaminergic systems.
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D007211:Indoles / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D010797:Phthalimides; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D013134:Spiperone / Q000378:metabolism*; D013468:Suloctidil / Q000494:pharmacology; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D013654:Taurine / Q000031:analogs & derivatives / Q000494:pharmacology*
D007211:Indoles; D010797:Phthalimides; D013654:Taurine; D013134:Spiperone; C046932:taltrimide; D013468:Suloctidil