[Effect of combined anesthetics on the activity of various myocardium enzymes].
It is demonstrated by experiments with rabbits that the Ca2+-ATP-ase activity is stabilized when using combined anesthetics (diacetylcholine + halothane + N2O) as distinct from application of halothane. A decrease in the cholinesterase activity is less pronounced than under the halothane action but more than with the diacetylcholine application. A decrease in the Na+, K+-ATP-ase activity is observed with all types of anesthesia. A considerable inhibition of creatine kinase under the action of combined anesthesia and halothane and an increase of the lactate dehydrogenase activity under diacetylcholine application in mitochondria are shown. Reliable differences in the succinic dehydrogenase activity are not detected.
D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors / Q000378:metabolism; D002800:Cholinesterase Inhibitors; D002802:Cholinesterases / Q000378:metabolism; D003402:Creatine Kinase / Q000037:antagonists & inhibitors / Q000378:metabolism; D006221:Halothane / Q000008:administration & dosage / Q000494:pharmacology; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D008929:Mitochondria, Heart / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*; D009609:Nitrous Oxide / Q000008:administration & dosage / Q000494:pharmacology; D011817:Rabbits; D012508:Sarcolemma / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D013390:Succinylcholine / Q000008:administration & dosage / Q000494:pharmacology
D000777:Anesthetics; D002800:Cholinesterase Inhibitors; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D003402:Creatine Kinase; D002802:Cholinesterases; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D013390:Succinylcholine; D009609:Nitrous Oxide; D006221:Halothane
Vliianie sredstv kombinirovannogo narkoza na aktivnost' nekotorykh fermentov miokarda.