title: Binding experiment KD values and physiologically active GABA concentrations: an only apparent contradiction?
abstract: An apparent contradiction exists between GABAA receptor binding KD's (less than 10(-6) M) and GABA concentrations physiologically active in various systems (greater than 10(-6) M). Taking in account that synaptic cleft GABA action and removal should be rather quick (within 2 ms) we show that in principle there is no contradiction between low KD values (100-150 nM) and high physiologically active GABA concentrations (greater than 40 microM).
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D002415:Cats; D002417:Cattle; D002540:Cerebral Cortex / Q000502:physiology; D007700:Kinetics; D051381:Rats; D011963:Receptors, GABA-A / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid