Phospholipids as a possible instrument for translocation of nascent proteins across biological membranes.
The interaction of phospholipids with precursor proteins, particularly with the mitochondrial precursor protein apocytochrome c is reviewed and integrated with other aspects of protein insertion and translocation, leading to a model for (apo)cytochrome c import into mitochondria, in which phospholipids play a dominant role.
D001692:Biological Transport; D003574:Cytochrome c Group / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism; D008563:Membrane Lipids / Q000502:physiology*; D008566:Membranes / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D008962:Models, Theoretical; D010713:Phosphatidylcholines / Q000502:physiology; D010718:Phosphatidylserines / Q000502:physiology; D010743:Phospholipids / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*
D003574:Cytochrome c Group; D008563:Membrane Lipids; D010713:Phosphatidylcholines; D010718:Phosphatidylserines; D010743:Phospholipids; D011506:Proteins