Schwann cell galactocerebroside of unmyelinated fibers is inducible by derivatives of adenosine 3',5'-monophosphate.
By using indirect immunofluorescence, galactocerebroside (galC) was detected on the surface of Schwann cells cultured from unmyelinated fibers of 10- to 12-day-old rat cervical sympathetic nerve trunk. By day 4 in vitro, galC-positive cells disappeared from the culture. When the 4-day cultures were treated with 1 mM 8-bromo cyclic AMP or dibutyryl cyclic AMP, galC reappeared in 72 h. The proportion of Schwann cells expressing galC was dependent on the concentration of cyclic AMP derivatives used.
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology*; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D002478:Cells, Cultured; D002554:Cerebrosides / Q000378:metabolism*; D005699:Galactosylceramides / Q000378:metabolism*; D005728:Ganglia, Sympathetic / Q000166:cytology; D009412:Nerve Fibers / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains; D012583:Schwann Cells / Q000187:drug effects* / Q000378:metabolism
D002554:Cerebrosides; D005699:Galactosylceramides; D015124:8-Bromo Cyclic Adenosine Monophosphate; D003994:Bucladesine