Second malignant neoplasms after childhood cancer: a report of three cases of osteogenic sarcoma.
The rising incidence of second malignant neoplasms after childhood cancer, whilst due in part to increasing numbers of survivors, is also thought to be related to increasingly more intensive combined modality treatment schedules. Three illustrative cases are reported in which radiation therapy in childhood for the first cancer is thought to have been a significant aetiological factor in the pathogenesis of the second malignancy (which in all three patients was an osteogenic sarcoma).
D001859:Bone Neoplasms / Q000209:etiology*; D002528:Cerebellar Neoplasms / Q000532:radiotherapy; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000532:radiotherapy; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy; D009378:Neoplasms, Multiple Primary / Q000209:etiology*; D012516:Osteosarcoma / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D012004:Rectal Neoplasms / Q000532:radiotherapy; D012208:Rhabdomyosarcoma / Q000532:radiotherapy; D013997:Time Factors; D009396:Wilms Tumor / Q000532:radiotherapy