The role of lipid peroxidation in pathogenesis of arrhythmias and prevention of cardiac fibrillation with antioxidants.
The present paper shows the arrhythmogenic effect of a direct induction of lipid peroxidation (LP) on isolated auricles; it is demonstrated that preendured stress potentiates this effect, while antioxidants prevent it. Subsequently, in studying the mechanism of the LP arrhythmogenic effect it was established that stress, like the LP induction, disorders the activity of Na, K-ATPase and accelerates thermodenaturation of this enzyme which plays a key role in maintaining the transmembrane potential and the electrical stability of the heart. Antioxidants prevent the enumerated shifts. Based on these data, the antioxidant BHT was successfully applied for prevention of the fall in cardiac fibrillation threshold in stress and experimental myocardial infarction, and also for prevention of cardiac fibrillation itself under acute ischemia and reoxygenation of the heart.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000378:metabolism; D001919:Bradycardia / Q000517:prevention & control*; D006329:Heart Conduction System / Q000187:drug effects; D007103:Immobilization; D066298:In Vitro Techniques; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism*; D009203:Myocardial Infarction / Q000517:prevention & control; D009206:Myocardium / Q000032:analysis; D051381:Rats; D012508:Sarcolemma / Q000032:analysis / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000032:analysis; D013315:Stress, Psychological / Q000150:complications
D000975:Antioxidants; D008054:Lipid Peroxides; D000254:Sodium-Potassium-Exchanging ATPase