title: Cyclotron production of no-carrier-added 206Bi (6.24 d) and 205Bi (15.31 d) as tracers for biological studies and for the development of alpha-emitting radiotherapeutic agents.
abstract: The production and radiochemical purification of no-carrier-added (NCA) bismuth isotopes (i.e. 6.24 d 206Bi and 15.31 d 205Bi) was studied. The Bi isotopes are intended for use as tracers in biodistribution studies and in the design and testing of alpha-emitting radiotherapeutic agents. The total cross sections and yields for the production of 206Bi and 205Bi from the proton bombardment of natural Pb targets were measured using the stacked-foils technique. A radiochemical method for the separation and purification of NCA Bi radioactivities from a multi-gram Pb target was also tested, modified, and improved to provide aqueous solutions of chemically and biologically useful amounts of NCA 206,205Bi for measuring tissue and subcellular-distributions, and for studies covering several chemical aspects of the development of Pb/Bi radiotherapeutic agents.
mesh_terms: D000512:Alpha Particles; D001729:Bismuth; D007854:Lead; D010315:Particle Accelerators; D011849:Radioactive Tracers; D011854:Radiochemistry; D011868:Radioisotopes / Q000627:therapeutic use*
chemical_list: D011849:Radioactive Tracers; D011868:Radioisotopes; D007854:Lead; D001729:Bismuth