title: Study of the chemical nature of Frp/3 cell recognition units for hepatitis A virus.
abstract: Research has been carried out in order to clarify the chemical nature of cell receptors interacting with a fast growing strain of hepatitis A virus (HAV) producing a cytopathic effect on Frp/3 cells. Cell surface susceptibility to HAV attachment has been studied after treatment with enzymes acting on different chemical groupings. Results obtained showed a lowering of cell susceptibility to HAV infection following the action of phospholipase A2, phospholipase C, trypsin and beta-galactosidase. These data suggested that phospholipids, proteins and galactose participate to the cellular receptorial area for HAV.
mesh_terms: D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D005455:Fluorescent Antibody Technique; D005690:Galactose / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000378:metabolism; D006507:Hepatovirus / Q000378:metabolism*; D006801:Humans; D010740:Phospholipases / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011991:Receptors, Virus / Q000378:metabolism*
chemical_list: D010743:Phospholipids; D011506:Proteins; D011991:Receptors, Virus; D010740:Phospholipases; D006026:Glycoside Hydrolases; D005690:Galactose