[Participation of cGMP in inhibitory mechanisms of the center of amphibian lymph hearts].
The effects of cAMP on generation of spontaneous rhythmic activity of lymphatic pacemaker neurons, was studied in fragments of the frog isolated perfused spinal cord. The cGMP depressed both the rhythm of the burst activity and the dibutyril-cAMP effect. The depressive effect of the cGMP was reversibly blocked with furosemide. The data obtained suggest existence of relationship between GABA-ergic inhibition of the pacemaker activity of lymphatic center and the cGMP concentration in pacemaker neurons.
D000818:Animals; D003994:Bucladesine / Q000037:antagonists & inhibitors; D006152:Cyclic GMP / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003864:Depression, Chemical; D005665:Furosemide / Q000494:pharmacology; D066298:In Vitro Techniques; D008208:Lymphatic System / Q000187:drug effects* / Q000294:innervation; D009433:Neural Inhibition; D011896:Rana temporaria; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D005680:gamma-Aminobutyric Acid; D003994:Bucladesine; D005665:Furosemide; D006152:Cyclic GMP
Ob uchastii tsGMF v mekhanizmakh tormozheniia tsentra limfaticheskikh serdets amfibiiĭ.