Resistance/susceptibility to lethal Sendai virus infection genetically linked to a mucociliary transport polymorphism.
Linkage was tested between a mucociliary transport polymorphism and resistance/susceptibility to lethal Sendai virus infection in segregant hybrid mice of C57BL/6J and DBA/2J parents. The distribution of paired phenotypes for tracheal mucociliary transport rates and susceptibility to lethal Sendai virus infection in 171 F1 X DBA/2J mice showed strong interaction of the parental phenotypes.
D000818:Animals; D002925:Ciliary Motility Disorders / Q000235:genetics*; D008040:Genetic Linkage; D007113:Immunity, Innate; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D010222:Parainfluenza Virus 1, Human / Q000472:pathogenicity; D018184:Paramyxoviridae Infections / Q000235:genetics*; D010641:Phenotype