Retinoic acid alters the metabolic 3H-labelling of glycosphingolipids.
Retinoic acid increases the incorporation of radioactivity from a mixture of [3H]-galactose and [3H]-glucosamine into glycosphingolipids of serum-starved quiescent human foreskin fibroblasts with a preferential labelling of ceramide mono- and dihexoside as compared to ceramide tri- and tetrahexoside. Under the conditions used, no similar change in the specific labelling of glycoprotein is observed. Alteration in [3H]-precursor uptake into glycolipids comparable to that seen under the influence of retinoic acid does not occur in the presence of phorbolester, colchicine, butyrate or after infection with cytomegalovirus.
D002087:Butyrates / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D002772:Cholera Toxin / Q000494:pharmacology; D003078:Colchicine / Q000494:pharmacology; D003586:Cytomegalovirus Infections / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006028:Glycosphingolipids / Q000378:metabolism*; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014212:Tretinoin / Q000494:pharmacology*
D002087:Butyrates; D006023:Glycoproteins; D006028:Glycosphingolipids; D008563:Membrane Lipids; D014212:Tretinoin; D002772:Cholera Toxin; D013755:Tetradecanoylphorbol Acetate; D003078:Colchicine