Nuclear DNA content in breast carcinomas with neuroendocrine differentiation.
Sixty-one breast carcinomas (54 infiltrating ductal carcinomas and seven infiltrating lobular carcinomas) were immunostained with anti-NSE and analysed with respect to nuclear DNA content. Nine of the 23 NSE-positive breast carcinomas were diploid, five were triploid, six tetraploid and three pentaploid. Twenty-one of the 38 NSE-negative tumours were diploid, 10 were triploid, seven tetraploid, and none were pentaploid. Three of the eight histologically grade I tumours in the NSE-positive group were aneuploid, whereas all the six grade I tumours in the NSE-negative group were diploid. The results show that a proportion of breast carcinomas with neuroendocrine differentiation are aneuploid and that aneuploid tumours that are grade I histologically are found in the NSE-positive group and not in the NSE-negative group.
D001943:Breast Neoplasms / Q000032:analysis* / Q000473:pathology; D002276:Carcinoid Tumor / Q000032:analysis; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D011003:Ploidies
D004273:DNA, Neoplasm; D010751:Phosphopyruvate Hydratase