A major metabolite of delta 1-tetrahydrocannabinol reduces its cataleptic effect in mice.
The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of delta 1-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action.
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced*; D015232:Dinoprostone; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology / Q000633:toxicity; D011464:Epoprostenol / Q000494:pharmacology; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D051379:Mice; D011458:Prostaglandins E / Q000494:pharmacology
D011458:Prostaglandins E; C016780:11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid; D013759:Dronabinol; D011464:Epoprostenol; D015232:Dinoprostone; D007213:Indomethacin