title: Evidence that colicin X is microcin B17.
abstract: The DNA replication inhibitor microcin B17 is a peptide antibiotic produced by Escherichia coli strains carrying plasmid pMccB17. Here we present evidence that antibiotic activities previously named colicin X are probably identical to microcin B17. Our results include comparison of the conditions of production of the antibiotics, their mode of action, cross-immunity of producer strains, and cross-resistance of resistant mutants. Plasmids encoding colicin X have been identified and shown to have a region of significant homology with the microcin B17-producing region of pMccB17 DNA.
mesh_terms: D001430:Bacteriocins / Q000096:biosynthesis / Q000235:genetics*; D002874:Chromosome Mapping; D003087:Colicins / Q000096:biosynthesis / Q000235:genetics*; D004262:DNA Restriction Enzymes; D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D005798:Genes, Bacterial; D010957:Plasmids
chemical_list: D001430:Bacteriocins; D003087:Colicins; D004269:DNA, Bacterial; C020411:microcin; D004262:DNA Restriction Enzymes