Protection from ischemia-induced cerebral edema in the rat by U-50488H, a kappa opioid receptor agonist.
U-50488 is a specific kappa opioid agonist which produces in rats water diuresis resulting in an elevation of plasma osmolarity. Pretreatment with U-50488H (the methanesulfonate salt) in Fisher rats prior to 4 h of bilateral carotid occlusion prevented the development of edema in the forebrain, and the effect was greater than that from pentobarbital anesthesia. An additional injection of an antidiuretic hormone which prevented the plasma hyperosmolarity also significantly reduced the anticerebral edemic effects of U-50488H. The plasma osmotic effect, however, may not completely account for the ischemic protection produced by U-50488H.
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000818:Animals; D001834:Body Water / Q000032:analysis; D001923:Brain Chemistry; D001929:Brain Edema / Q000378:metabolism / Q000517:prevention & control*; D002545:Brain Ischemia / Q000150:complications*; D004231:Diuresis / Q000187:drug effects; D008297:Male; D009994:Osmolar Concentration; D011188:Potassium / Q000032:analysis; D011759:Pyrrolidines / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011916:Rats, Inbred F344; D011957:Receptors, Opioid / Q000187:drug effects*; D012964:Sodium / Q000032:analysis; D014667:Vasopressins / Q000494:pharmacology
D011759:Pyrrolidines; D011957:Receptors, Opioid; D014667:Vasopressins; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D012964:Sodium; D011188:Potassium