title: [Morphologic manifestations of the medicinal lysis of a coronary artery thrombus].
abstract: Morphologic studies of coronary arterial thrombi have shown immature fibrin fibres to prevail in those, with fibrin degradation products always present. This fact suggests that fibrinolytic components of hemostasis, limiting the rates of fibrin polymerization and maturation, may participate in thrombogenesis. At the same time, macrophages that phagocytose fibrin and blood cells (platelets and erythrocytes) become activated since the early hours of the thrombus' existence. Selective administration of fibrinolytic activators destroys the fibrin network of the thrombus, blood cells are washed away by the blood flow and the thrombus diminishes in volume. At the same time, its macrophagal response is activated, and fibrin and fibrin degradation products are eliminated from the vascular lumen.
mesh_terms: D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy*; D003328:Coronary Thrombosis / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D010447:Peptide Hydrolases / Q000627:therapeutic use; D013300:Streptokinase / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D010447:Peptide Hydrolases; D013300:Streptokinase; C035188:plasmakinase
vernacular_title: Morfologicheskie proiavleniia medikamentoznogo lizisa tromba koronarnykh arteriĭ.