Morphometric analysis and fine structure of the vestibular epithelium of aged C57BL/6NNia mice.
The vestibular organs of young and very old C57BL/6NNia (B6) mice were compared by light and electron microscopy. Hair cell density decreased an average of 14% in the utricle, 19% in the saccule and posterior crista, 23% in the horizontal crista, and 24% in the anterior crista. Hair cell size remained the same throughout the mouse's life span as did the ratio of Type I to Type II hair cells. The most apparent sign of advanced age was dense inclusions found in sensory and supporting cells. Although small inclusions were present at five weeks, by 29 months, additional, larger forms appeared. An unusual melanin-like form was characteristic of old Type I hair cells. Synaptic morphology and synaptic bodies were well preserved even in very old B6 mice. Elongated bars were common in Type I hair cells and spheroid synaptic bodies were the most common form in Type II hair cells. Large clusters of synaptic bodies occurring in both young and old mice were seen only in Type I hair cells. Although the B6 strain suffers from genetically determined early cochlear degeneration, it does not experience early degeneration of the peripheral vestibular organs.
D000375:Aging / Q000473:pathology*; D000818:Animals; D005260:Female; D002479:Inclusion Bodies / Q000648:ultrastructure; D051379:Mice; D008810:Mice, Inbred C57BL; D011984:Sensory Receptor Cells / Q000648:ultrastructure; D013569:Synapses / Q000648:ultrastructure; D014722:Vestibule, Labyrinth / Q000648:ultrastructure*