title: Sintered hydroxyapatite for a percutaneous device and its clinical application.
abstract: The sintered hydroxyapatite was designed to be utilized as a percutaneous device. The device was percutaneously fixed through the back skin of mongrel dogs. The tissue reaction around the implants was examined histologically. At 1 month the sintered hydroxyapatite was closely contacted with the skin tissue and downgrowth of epidermis was not observed. The long-term implantation ranging from 3 to 17 months showed that the depth of epidermis downgrowth was limited to only 1 mm. The amino acid composition of fibrous capsule formed around the hydroxyapatite showed close resemblance to vertebrate periosteum. It was confirmed that the sintered hydroxyapatite had good compatibility and long-term stability with skin tissue.
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001672:Biocompatible Materials; D001794:Blood Pressure; D004285:Dogs; D017886:Durapatite; D006801:Humans; D006882:Hydroxyapatites; D012867:Skin / Q000166:cytology; D012879:Skin Physiological Phenomena
chemical_list: D000596:Amino Acids; D001672:Biocompatible Materials; D006882:Hydroxyapatites; D017886:Durapatite