[Post-crisis elevation of adrenocorticotropic hormone and prolactin in epileptic children].
In six children, aged from 8 to 12 years, presenting with primary generalized epilepsy a significant rise in plasma ACTH and prolactin levels (as compared with levels measured 5 days later) was observed either during a generalized seizure demonstrated by EEG (3 cases) or within 1 hour of a generalized seizure (3 cases). The neurophysiological basis for these post-epileptic endocrine disturbances is a sudden depression of dopaminergic and GABA-ergic pathways. As a result, these endocrine changes, already well documented in adults, may be regarded as a good biological marker of the epileptic origin of a paroxysmal attack.
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D002648:Child; D004827:Epilepsy / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood*; D013997:Time Factors
D000324:Adrenocorticotropic Hormone; D011388:Prolactin
Elévation post-critique de l'hormone adrénocorticotrope et de la prolactine chez les enfants épileptiques.