Factors affecting transmission of Wuchereria bancrofti by anopheline mosquitoes. 2. Damage to ingested microfilariae by mosquito foregut armatures and development of filarial larvae in mosquitoes.
Microfilariae (mf) of Wuchereria bancrofti from the midgut of 639 Anopheles gambiae, 557 An. arabiensis, 117 An. melas and 9 An. funestus were examined immediately after the mosquitoes had fed on carriers with different densities of mf. The percentages of mf damaged during ingestion were 57.1-60.0 in An. gambiae, 33.3-50.6 in An. arabiensis and 38.7-55.7 in An. melas. In each species the percentage of mf damaged was independent of mf density in the human host. A further 3657 An. gambiae, 2875 An. arabiensis, 347 An. melas and 32 An. funestus were examined 7 d or more after feeding on mf carriers. In An. gambiae and An. arabiensis, mean numbers of larvae per mosquito were strongly correlated to mf blood density, with similar regression slopes to those obtained from the regression of mf blood density on mean uptake of mf/mosquito. The ratio of mean numbers of larvae per mosquito to mean numbers of intact mf ingested per mosquito increased as the density of mf in the human host increased in An. gambiae and An. arabiensis, but decreased in An. melas as host mf density increased.
D000818:Animals; D000852:Anopheles / Q000469:parasitology* / Q000502:physiology; D004605:Elephantiasis, Filarial / Q000635:transmission*; D005247:Feeding Behavior; D005260:Female; D005368:Filariasis / Q000635:transmission*; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology*; D007422:Intestines / Q000502:physiology; D008842:Microfilariae / Q000254:growth & development; D013997:Time Factors; D014957:Wuchereria / Q000502:physiology*; D014958:Wuchereria bancrofti / Q000254:growth & development / Q000502:physiology*