Weak and unexpected mutagenicity to Salmonella of the rat hepatocarcinogen methapyrilene.
The rat liver carcinogen methapyrilene is shown to be a selective mutagen to strain TA1535 of Salmonella typhimurium when tested in the absence of S9 mix and using the standard plate-incorporation assay protocol. The activity observed was weak but was reproducible for a range of samples on many occasions of test and was not due to impurities. These data contrast with six earlier reports of the inactivity of this chemical in the Salmonella mutation assay.
D000631:Aminopyridines / Q000633:toxicity*; D000818:Animals; D066298:In Vitro Techniques; D008701:Methapyrilene / Q000633:toxicity*; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation / Q000187:drug effects; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*
D000631:Aminopyridines; D009153:Mutagens; D008701:Methapyrilene