A 2-deoxy analogue of KDO as the first inhibitor of the enzyme CMP-KDO synthetase.
The two KDO analogues 2,6-anhydro-3-deoxy-D-glycero-D-galacto-octonate and 2,6-anhydro-3-deoxy-D-glycero-D-talo-octonate were synthesized and tested as inhibitors of the enzyme CTP:CMP-deoxyoctulosonate cytidylyltransferase (CMP-KDO synthetase) from Gram-negative bacteria. Only compound 4, the 2-deoxy analogue of beta-KDO-pyranose, was found to be an inhibitor with a Ki of 3.9 microM.
D001665:Binding Sites; D004926:Escherichia coli / Q000201:enzymology; D007700:Kinetics; D009713:Nucleotidyltransferases / Q000037:antagonists & inhibitors*; D012486:Salmonella typhimurium / Q000201:enzymology; D013400:Sugar Acids / Q000494:pharmacology*
D013400:Sugar Acids; C052138:2,6-anhydro-3-deoxyoctonate; D009713:Nucleotidyltransferases; C028984:3-deoxy-manno-octulosonate cytidyltransferase