title: [Stimulation of arbovirus reproduction in cell cultures by hormones].
abstract: The possibility of stimulation of reproduction and antigen production of arboviruses (tick-borne encephalitis, Japanese encephalitis, western equine encephalomyelitis) in cell cultures (SPEV, chick embryo fibroblasts) by using various hormones (insulin, ACTH, hydrocortisone) and optimal temperatures was demonstrated. The stimulating effect depended upon the type of cell culture, virus, method of cell treatment, and manifested by a significant increase of the hemagglutinating and infectious activity of the replicating viruses. Differences in the structure of populations, biophysical and antigenic properties of the viruses associated with the conditions of their reproduction in vitro were observed.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001103:Arboviruses / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D002642:Chick Embryo; D004664:Encephalitis Virus, Japanese / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D004667:Encephalitis Virus, Western Equine / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D004669:Encephalitis Viruses, Tick-Borne / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D006728:Hormones / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D013268:Stimulation, Chemical; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000956:Antigens, Viral; D006728:Hormones; D007328:Insulin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
vernacular_title: Stimuliatsiia reproduktsii arbovirusov v kletochnykh kul'turakh gormonami.