[Action of alpha-tocopherol on the enzymes of the electron transport chains in the liver microsomes of irradiated rats].
Five days following single whole-body gamma irradiation of rats (8.5 Gy) the rate of NADPH and NADH oxidation, the activity of NADPH-cytochrome P-450 and NADH-cytochrome b5 reductases, and the content of cytochromes P-450 and b5 were found to decrease. The intragastric administration of alpha-tocopherol (100 mg/kg, two times a day) produced a normalizing effect.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004579:Electron Transport / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology / Q000528:radiation effects; D010084:Oxidation-Reduction / Q000187:drug effects / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000201:enzymology; D051381:Rats; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use*; D014916:Whole-Body Irradiation
D014810:Vitamin E
Deĭstvie al'fa-tokoferola na fermenty élektron-transportnykh tsepeĭ mikrosom pecheni obluchennykh krys.