Mechanisms of the vascular effect of pressor hormones.
There exists a considerable gap between the recognition of the effects of pressor hormones and the understanding of their mechanisms. Studies are necessary to provide a more accurate basis for potential therapeutic interventions on the hormonal mechanisms of hyper- and hypotensive states. From recent and previous experimental results, a modified model of vascular smooth muscle cell activation is emerging. In this model, contraction is a complex process involving Ca2+ release, protein kinase C and ionic channel activation and modification in pH and energy metabolism. The combined action of these processes is necessary for the full expression of the contractile response.
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*
D000804:Angiotensin II; D001127:Arginine Vasopressin; D002118:Calcium; D009638:Norepinephrine