title: Indomethacin-associated cholestasis.
abstract: A patient with no prior history of liver disease developed mild cholestasis, with a moderate elevation of the serum alkaline phosphatase level, several days after instituting indomethacin therapy. The cholestasis resolved soon after the medication was discontinued. An extensive workup, including liver biopsy, revealed no alternative cause. Despite extensive use, indomethacin therapy has been associated with hepatic injury in only nine previously reported cases, as near as we can tell.
mesh_terms: D002779:Cholestasis / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D007213:Indomethacin