The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a growth factor gene with sequence similarity to those encoding epidermal growth factor and transforming growth factor alpha.
Degenerate oligonucleotide probes corresponding to a highly conserved region common to epidermal growth factor, transforming growth factor alpha, and vaccinia growth factor were used to identify a novel growth factor gene in the Shope fibroma virus genome. Sequence analysis indicates that the Shope fibroma growth factor is a distinct new member of this family of growth factors.
D000595:Amino Acid Sequence; D001483:Base Sequence; D004262:DNA Restriction Enzymes; D004815:Epidermal Growth Factor / Q000235:genetics*; D012776:Fibroma Virus, Rabbit / Q000235:genetics*; D005796:Genes; D005814:Genes, Viral; D006133:Growth Substances / Q000235:genetics*; D010455:Peptides / Q000235:genetics*; D011212:Poxviridae / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D016211:Transforming Growth Factor alpha; D015291:Transforming Growth Factors
D006133:Growth Substances; D010455:Peptides; C056692:Shope fibroma virus growth factor; D016211:Transforming Growth Factor alpha; D004815:Epidermal Growth Factor; D015291:Transforming Growth Factors; D004262:DNA Restriction Enzymes