title: Dedifferentiated chondrosarcoma: an ultrastructural study of two cases, with immunocytochemical correlations.
abstract: The clinicopathologic features of two cases of dedifferentiated chondrosarcoma (DCS) are presented, in which anaplastic components showed the electron microscopic features of malignant fibrous histiocytoma, as well as immunoreactivity for alpha-1-antitrypsin and alpha-1-antichymotrypsin. Rare cells also displayed S100 protein in high-grade areas of the primary tumors, but a pulmonary metastasis lacked this determinant. These findings could be interpreted as reflecting a retained potential for primitive chondrogenesis in primary DCS, which may be lost in its metastases. In all other respects, this tumor appears to assume the morphological and immunocytochemical attributes of a fibrohistiocytic neoplasm.
mesh_terms: D001859:Bone Neoplasms / Q000032:analysis / Q000648:ultrastructure*; D002813:Chondrosarcoma / Q000032:analysis / Q000648:ultrastructure*; D005266:Femoral Neoplasms / Q000032:analysis / Q000648:ultrastructure*; D018219:Histiocytoma, Benign Fibrous / Q000032:analysis / Q000648:ultrastructure*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis; D012540:Scapula; D014746:Vimentin / Q000032:analysis; D000514:alpha 1-Antichymotrypsin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D009418:S100 Proteins; D014746:Vimentin; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin