Characterization of peripheral blood T lymphocyte subsets in pulmonary sarcoidosis.
The peripheral blood of sarcoidosis patients has been shown to have abnormalities in the T Lymphocyte subsets. There is a consistent reduction in the helper/suppressor T Lymphocyte ratio caused by an increase in suppressor cell percentage as determined by monoclonal antibodies. These findings suggest that the peripheral blood T Lymphocyte subsets may be a useful adjunct for determining the underlying immunological cellular dysfunction in sarcoidosis patients.
D000328:Adult; D000911:Antibodies, Monoclonal; D002469:Cell Separation / Q000379:methods; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008168:Lung / Q000000981:diagnostic imaging / Q000503:physiopathology; D008171:Lung Diseases / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011859:Radiography; D012507:Sarcoidosis / Q000175:diagnosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal; D007703:Peptidyl-Dipeptidase A