title: Topical tretinoin in the treatment of aging skin.
abstract: We review the use of topical tretinoin (all-trans-retinoic acid) in the treatment of aging skin. We have found topical tretinoin capable of improving aged-appearing skin in both a double-blind, vehicle-controlled trial and our clinic patients. The most impressive improvement occurs after application of tretinoin 0.1% cream for 8 to 12 months. Side effects have been limited to a mild, transient, and clinically insignificant burning sensation in the eyes and mild irritation of tretinoin-exposed skin.
mesh_terms: D000287:Administration, Topical; D000375:Aging / Q000187:drug effects*; D000818:Animals; D004311:Double-Blind Method; D005145:Face; D006801:Humans; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects*; D014212:Tretinoin / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D014212:Tretinoin