[Use of gammaphos for protecting the brain from delayed radiation damage].
The influence of a radioprotector, gammaphos, on the development of delayed vascular changes and necrosis in rat brain following local brain irradiation with 25 Gy was investigated. The radioprotective effect was manifested by both the morphometric parameters of vessels and the survival rate and relative number of animals with gross vascular abnormalities and brain necrosis. There was a causative relationship between the development of gross vascular abnormalities and the occurrence of brain necrosis after exposure to moderate radiation doses.
D004999:Amifostine / Q000627:therapeutic use*; D000818:Animals; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000528:radiation effects; D001930:Brain Injuries / Q000473:pathology / Q000517:prevention & control*; D004307:Dose-Response Relationship, Radiation; D004353:Drug Evaluation, Preclinical; D008833:Microcirculation / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D009336:Necrosis; D009946:Organothiophosphorus Compounds / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000473:pathology / Q000517:prevention & control*; D011837:Radiation-Protective Agents; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D009946:Organothiophosphorus Compounds; D011837:Radiation-Protective Agents; D004999:Amifostine
Primenenie gammafosa dlia zashchity golovnogo mozga ot otdalennykh luchevykh povrezhdeniĭ.