Intrathecal application of drugs for muscle hypertonia.
The literature regarding the intrathecal use of morphine, baclofen, and midazolam to treat spasticity is reviewed. Nine patients with significant spasticity due to different etiologies were treated. Morphine and midazolam decreased spasticity but did not change the patient's functional status. Baclofen improved patient status, but was associated with significant CNS depression in two cases.
D001418:Baclofen / Q000008:administration & dosage*; D006801:Humans; D007278:Injections, Spinal; D008874:Midazolam / Q000008:administration & dosage*; D009020:Morphine / Q000008:administration & dosage*; D009122:Muscle Hypertonia / Q000188:drug therapy*
D009020:Morphine; D001418:Baclofen; D008874:Midazolam