Determinants of pulmonary fibrosis and lipidosis in the silica model.
The conditions which might favour development of the fibrotic or the lipid component of the pulmonary reaction to inhaled quartz were examined in rats. Smaller particle size and freedom from surface contamination by amorphous silica or iron oxide, status of the animals whether specific pathogen-free or conventional, and the resistance of cell membranes to damage appeared to bear on fibrogenesis. Increased membrane stability by treatment with polyvinylpyridine-N-oxide abolished not only the fibrosis but also the response of type II cells and hence lipidosis. The rate and intensity of quartz deposition may also affect the response, a low concentration inhaled over a long period favouring nodulation. No other manipulations, environmental or pharmacological, succeeded in inhibiting lipidosis to the benefit of fibrosis. Guinea pigs, however, behaved differently, their reaction being characterized by massive alveolar accumulation of dust-bearing macrophages and type II cell hyperplasia but not by lipidosis. The species variation is unexplained but macrophage predominance may represent a phase that later transforms to lipidosis. The experimental findings may have implications for forms of pneumoconiosis other than silicosis.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D004158:Diphenylacetic Acids / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007213:Indomethacin / Q000494:pharmacology; D008064:Lipidoses / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D008168:Lung / Q000473:pathology; D008264:Macrophages / Q000187:drug effects / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D010276:Parasympatholytics / Q000494:pharmacology; D011144:Polyvinylpyridine N-Oxide / Q000494:pharmacology; D011658:Pulmonary Fibrosis / Q000209:etiology* / Q000473:pathology; D011791:Quartz / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012822:Silicon Dioxide / Q000633:toxicity*; D013045:Species Specificity
D004158:Diphenylacetic Acids; D010276:Parasympatholytics; D011791:Quartz; D012822:Silicon Dioxide; C003148:fenpipramide; D011144:Polyvinylpyridine N-Oxide; D007213:Indomethacin