Asbestos exposure and gastrointestinal malignancy review and meta-analysis.
The epidemiologic literature linking asbestos exposure with gastrointestinal malignancy is reviewed. Problems in comparing studies are discussed, appropriate strategies for comparison are developed, and study results are pooled using a model which accounts for both intrastudy and interstudy variability. Stratification of cohorts by dose reveals that significant asbestos exposure, as indicated by a lung cancer standardized mortality ratio (SMR) of at least 200, is associated with an elevated gastrointestinal cancer of SMR for five of six points examined [corrected].
D001194:Asbestos / Q000009:adverse effects*; D005770:Gastrointestinal Neoplasms / Q000209:etiology*; D006801:Humans; D009784:Occupational Diseases / Q000209:etiology*; D012107:Research Design
D001194:Asbestos