title: [Changes in the segmental flexibility and conformation stability of side groups in spin-labeled molecules of 2 IgG subclasses in the serum of normal cows and cows in various pathological states].
abstract: The segmental flexibility of molecules from two IgG subclasses of cows' blood serum was first observed. It was shown that IgG1 molecule has a more flexible hinge region than IgG2 molecule and lower local conformational stability. At the same time the states of IgG1 and IgG2 molecules determined by dynamic-steric characteristics for ill and healthy cows practically did not differ.
mesh_terms: D000818:Animals; D002417:Cattle; D004578:Electron Spin Resonance Spectroscopy; D007074:Immunoglobulin G; D007945:Leukemia, Lymphoid / Q000097:blood / Q000276:immunology*; D011487:Protein Conformation; D013113:Spin Labels
chemical_list: D007074:Immunoglobulin G; D013113:Spin Labels
vernacular_title: Razlichiia v segmental'noĭ gibkosti i lokal'noĭ konformatsionnoĭ podvizhnosti bokovykh grupp spin-mechenykh molekul dvukh podklassov IgG syvorotki krovi korov v norme i pri patologii.