Relationship between enhanced reactivation and mutagenesis of u.v.-irradiated human cytomegalovirus in normal human cells.
The survival of u.v.-irradiated human cytomegalovirus (HCMV) on u.v.-irradiated human IAFP-1 cells was increased over that on unirradiated cells. Irradiated virus had a higher forward mutation frequency towards temperature sensitivity in irradiated than in unirradiated cells. Enhanced reactivation of u.v.-irradiated HCMV is thus mutagenic in normal human cells. This observation supports the possible induction of an error-prone mode of DNA repair in u.v.-irradiated mammalian cells.
D002460:Cell Line; D003587:Cytomegalovirus / Q000235:genetics / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008168:Lung; D009154:Mutation; D014466:Ultraviolet Rays