[ICO-13 monoclonal antibodies to the differentiation antigen of human hemopoietic cells].
Monoclonal antibodies (Mab) ICO-13 of IgM isotype reacted in indirect surface immunofluorescence test with 88.5 +/- 3.4% of thymocytes and 7.1 +/- 2.4% of T cells, but failed to react with other peripheral blood cells from healthy donors. The antigen disappeared in cells stored at 4 degrees C overnight or at -196 degrees C in liquid nitrogen. The antigen detected by Mab ICO-13 was expressed on blast cells of acute lymphoblast leukemias and lymphomas. The antigen was absent in chronic lymphoblast leukemia and blast crisis of chronic myeloid leukemia.
D000911:Antibodies, Monoclonal / Q000032:analysis*; D000943:Antigens, Differentiation / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D007075:Immunoglobulin M / Q000032:analysis; D007938:Leukemia / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D007075:Immunoglobulin M
Monoklonal'nye antitela IKO-13 k differentsirovochnomu antigenu gemopoéticheskikh kletok cheloveka.