Do natural autoantibodies play an important role in the elimination of senescent or damaged red blood cells?
Natural autoantibodies (NAAbs) are an important constituent of circulating immunoglobins. Some demonstrate polyspecific reactivity and high idiotypic connectivity. For example, they are reactive with DNA and cytoskeleton protein; others exhibit restricted binding specificity. Among several hypotheses, we have explored the possibility that NAAbs constitute a physiologic system in the organism that participates in the elimination of dead tissues and cellular debris by opsonization and phagocytosis.
D001323:Autoantibodies / Q000276:immunology*; D004905:Erythrocyte Aging; D006801:Humans
D001323:Autoantibodies