The antiherpesvirus activity and cytotoxicity of sangivamycin.
Sangivamycin, 4-amino-5-carboxamido-7-(beta-D-ribofuranosyl)-pyrrolo[2,3-d]-pyrimidine is a structural analog of adenosine belonging to a group of nucleosides classified as pyrrolopyrimidines. Sangivamycin, an adenosine deaminase resistant analog, was found to inhibit the replication of three strains of herpes simplex virus type 1 (HSV-1) by 50% (ED50) at a concentration approximately equal to the concentration which inhibits cell growth by 50% (LD50). Both Vero cells and rabbit corneal stromal cells in exponential growth were about 10-fold more sensitive to the drug than quiescent cells. The selectivity indices of sangivamycin indicated that the drug was not a highly selective antiviral agent and, therefore, would offer no advantage over drugs currently available for the treatment of herpetic keratitis.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003319:Corneal Stroma / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D007635:Keratitis, Dendritic / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D011741:Pyrimidine Nucleosides / Q000627:therapeutic use; D011817:Rabbits; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology; D014709:Vero Cells / Q000187:drug effects / Q000382:microbiology; D014779:Virus Replication / Q000187:drug effects
D011741:Pyrimidine Nucleosides; C005699:sangivamycin