title: The Carey-Coons percutaneous biliary endoprosthesis: a three-centre experience in 87 patients.
abstract: Eighty-seven patients with malignant obstruction of the biliary tract from three centres and deemed unsuitable for surgery underwent insertion of the 'Carey-Coons' transhepatic endoprosthesis. It was successfully introduced in all, with early relief of cholestasis in 97%. The 30 day mortality rate was 11.5%, which is lower than reported in series using different endoprostheses. Two fifths of patients had complications, especially cholangitis. Despite its ease of insertion the design of the endoprosthesis may be related to the high incidence of cholangitis and to formation of biliary sludge and occlusion found in follow up. Although the anchoring threads prevented migration, they may have played a role in infection at the skin entry site in four patients and in tumour seeding to the skin in a further two. Still further improvements in endoprosthesis design are desirable.
mesh_terms: D002759:Adenoma, Bile Duct / Q000628:therapy*; D000368:Aged; D001650:Bile Duct Neoplasms / Q000628:therapy*; D002761:Cholangitis / Q000209:etiology; D002779:Cholestasis / Q000628:therapy*; D006801:Humans; D019736:Prostheses and Implants; D011474:Prosthesis Design / Q000009:adverse effects; D011475:Prosthesis Failure