Treatment of cytomegalovirus retinitis in a patient with AIDS with 9-(1,3-dihydroxy-2-propoxymethyl)guanine.
Asymptomatic retinal lesions were found on annual ophthalmic examination in a 38-year-old homosexual man with the acquired immune deficiency syndrome (AIDS). The lesions were compatible with cytomegalovirus retinitis and progressed. Treatment with 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) resulted in regression of the lesions and improvement in his overall clinical condition. The retinal lesions in AIDS are reviewed.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000212:Acyclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D003586:Cytomegalovirus Infections; D015774:Ganciclovir; D006801:Humans; D008297:Male; D012160:Retina / Q000473:pathology; D012173:Retinitis / Q000150:complications / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
D015774:Ganciclovir; D000212:Acyclovir