title: Steady-state evaluation of two controlled-release theophylline preparations in children.
abstract: The absorption profiles of Theolair-SR and Theo-Dur were studied in 23 asthmatic children (mean age 11 years). A 250-mg dose of each product was administered twice a day until steady state was attained (mean, 8 days). Both products maintained adequate theophylline levels over 12 hours, although Theolair-SR gave significantly higher serum levels and a 19% greater extent of theophylline absorption. The mean Cmax-Cmin was also significantly greater for Theolair-SR. Both products should be considered comparable for practical use.
mesh_terms: D000042:Absorption; D000293:Adolescent; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D013806:Theophylline / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use
chemical_list: D003692:Delayed-Action Preparations; D013806:Theophylline