title: Effect of left atrial to left femoral artery bypass and renin-angiotensin system blockade on renal blood flow and function during and after thoracic aortic occlusion.
abstract: Temporary thoracic aortic occlusion can result in renal insufficiency with or without adjuncts to avoid distal hypoperfusion. In a canine model of thoracic aortic occlusion, left atrial to left femoral bypass was compared with blockade of the renin-angiotensin system. Renin-angiotensin system blockade with the converting enzyme inhibitor, MK422, resulted in restoration of baseline renal blood flow and glomerular filtration 30 minutes after cross-clamp release. Left atrial to left femoral bypass resulted in significant reduction in both renal blood flow and glomerular filtration 30 minutes after cross-clamp release. Stimulation of the renin-angiotensin system plays a significant role in the altered renal hemodynamics and glomerular filtration rates after thoracic aortic occlusion.
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D001013:Aorta, Thoracic / Q000502:physiology*; D016275:Atrial Function; D001794:Blood Pressure; D006328:Cardiac Catheterization; D004285:Dogs; D004656:Enalapril / Q000031:analogs & derivatives* / Q000494:pharmacology; D015773:Enalaprilat; D005263:Femoral Artery / Q000502:physiology; D005919:Glomerular Filtration Rate; D006339:Heart Rate; D010477:Perfusion; D012079:Renal Circulation; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System; D014556:Urine / Q000378:metabolism
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril; D012083:Renin; D015773:Enalaprilat