DMSO induces reactivation of cytomegalovirus in vitro from spleens of latently infected mice. Brief report.
Reactivation of murine cytomegalovirus in spleen explant cultures from latently infected CD 1 mice was studied. A significant increase in the incidence of reactivation was observed when 200 mM DMSO was included in the culture medium. Virus could also be reactivated from the bone marrow of some mice.
D000818:Animals; D001853:Bone Marrow / Q000382:microbiology; D003587:Cytomegalovirus / Q000187:drug effects*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D066298:In Vitro Techniques; D051379:Mice; D013154:Spleen / Q000382:microbiology*; D014775:Virus Activation / Q000187:drug effects*
D004121:Dimethyl Sulfoxide