title: Suppression of glomerular IgA deposition in ddY mice through periodic injections of lipopolysaccharides.
abstract: We investigated the role of lipopolysaccharides (LPS) in glomerular IgA deposition of ddY mice. The incidence of IgA deposition was lower in the LPS-injected mice at 10 and 13 months of age as compared with that of their age-matched controls (10 months, LPS 20% vs control 60%; 13 months, LPS 14% vs control 100%). Serum levels of IgA were lower in the LPS-injected mice than in the control mice. There were no appreciable differences in the percentage value of Thy-1+ cells, the ratio of Lyt-1+/Lyt-2+ cells, mitogenic responses, or IL-1 activities between the LPS-injected and the control mice. On the other hand, the IgA responses of spleen and Peyer's patch cells in the LPS-injected mice were lower than those observed in the control mice. These results suggest that the persistent use of LPS directly suppresses gut-associated lymphoreticular tissue (GALT), and that the lower IgA response in GALT induced by LPS causes suppression of glomerular IgA deposition in ddY mice.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D005455:Fluorescent Antibody Technique; D005922:Glomerulonephritis, IGA / Q000517:prevention & control*; D007136:Immunoglobulins / Q000032:analysis; D007375:Interleukin-1 / Q000032:analysis; D007413:Intestinal Mucosa / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology; D008070:Lipopolysaccharides / Q000008:administration & dosage*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000145:classification; D008264:Macrophages / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains; D008854:Microscopy, Electron; D010581:Peyer's Patches / Q000276:immunology; D013154:Spleen / Q000276:immunology
chemical_list: D007136:Immunoglobulins; D007375:Interleukin-1; D008070:Lipopolysaccharides