[Differences in the excitatory action of acetylcholine and mecholine on mechanosensitive high-threshold C-axonal units of the skin in the cat].
Intraarterial acetylcholine (Ach) and acetyl-beta-methylcholine (metacholine, Mch) excite feline high-threshold C-fiber mechanosensitive cutaneous sensory units (SU) in a different way. Ach in noxious (algogenic for humans) concentrations of 10 micrograms/ml and more induces a high-frequency discharge, with mean frequency of impulses at its peak being 4-12 Hz. This discharge seems to result from activation of N-cholinoreceptors because non-noxious and nonalgogenic M-agonist Mch as well as Ach in subnoxious concentrations induce in SU only a low-frequency discharge with a mean frequency of impulses 0.5-3.5 Hz. The data are discussed in connection with nociception and tissue chemoreception.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005071:Evoked Potentials / Q000187:drug effects; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000494:pharmacology*; D009412:Nerve Fibers / Q000187:drug effects* / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D011984:Sensory Receptor Cells / Q000187:drug effects* / Q000502:physiology; D012867:Skin / Q000187:drug effects / Q000294:innervation*; D013268:Stimulation, Chemical; D013997:Time Factors
D008688:Methacholine Compounds; D016210:Methacholine Chloride; D000109:Acetylcholine
Razlichiia vozbuzhdaiushchego deĭstviia atsetilkholina i mekholina na mekhanochuvstvitel'nye vysokoporogovye C-aksonnye edinitsy kozhi koshki.