title: Subacute sensory neuronopathy secondary to dorsal root ganglionitis in primary Sjögren's syndrome.
abstract: Sensory neuropathies, particularly trigeminal neuropathy, have been recognized as neurological complications of Sjögren's syndrome, but the pathogenesis has not been established. We describe a woman with primary Sjögren's syndrome who developed a progressive debilitating subacute sensory neuronopathy. Results of electrophysiological studies were consistent with involvement of the trigeminal and dorsal root ganglia. A thoracic dorsal root ganglion biopsy showed lymphocytic infiltration and degeneration of ganglion cells. We believe that this is the first description of biopsy-documented dorsal root ganglionitis in a subacute sensory neuronopathy associated with Sjögren's syndrome and that the finding suggests an immunopathogenic basis.
mesh_terms: D005260:Female; D005727:Ganglia, Spinal / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009475:Neurons, Afferent; D010523:Peripheral Nervous System Diseases / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000150:complications* / Q000473:pathology