The expression of S-100 protein and neuron-specific enolase in meningiomas.
The distribution of S-100 protein and neuron-specific enolase (NSE) was examined in 19 meningiomas using the peroxidase-antiperoxidase (PAP) immunohistochemical technique. Positive cytoplasmic staining for NSE was observed in 16 tumors, and comparable staining for S-100 protein was observed in eight tumors. The finding of S-100 protein and NSE immunoreactivity in fibroblastic, meningiotheliomatous, and transitional meningiomas raises the possibility that these morphologically distinct neoplasms derive from a common pluripotential cell capable of differentiation along diverse paths.
D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008579:Meningioma / Q000032:analysis* / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000032:analysis*; D009418:S100 Proteins / Q000032:analysis*
D014408:Biomarkers, Tumor; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase