Different postnatal ontogeny of two [3H]neurotensin binding sites in rat brain.
Two distinct neurotensin binding sites have been identified in rat brain: the NT1-acceptor site (levocabastine-sensitive) and the NT2-receptor site. In rat forebrain, NT2-receptors were present at birth, revealed a maximal level (13.8 fmol/mg tissue) on day 10 of postnatal life but a much lower plateau (3.0 fmol/mg tissue) in adult rats. NT1-acceptors were not detected before day 10 and became maximal at day 30. It is suggested that the loss of NT2-receptor sites during the postnatal development may be the expression of the regression of a transient redundancy of neuronal connections.
D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D005625:Frontal Lobe / Q000254:growth & development / Q000378:metabolism; D009496:Neurotensin / Q000378:metabolism*; D051381:Rats; D018028:Receptors, Neurotensin; D017981:Receptors, Neurotransmitter / Q000145:classification / Q000378:metabolism / Q000502:physiology*
D018028:Receptors, Neurotensin; D017981:Receptors, Neurotransmitter; D009496:Neurotensin