[Amplification of c-myc proto-oncogene in primary tumors, metastases and blood leukocytes of patients with ovarian cancer].
The structure of DNA sequences homologous to the viral myc oncogene from ovarian tumours, intact tissues and the same patients peripheral blood leukocytes has been studied. The Southern blot analysis of malignant tumour DNA reveals amplification of c-myc protooncogene of 3 from 11 patients. Metastases DNAs of two from those patients also contain multiple copies of c-myc. No myc gene amplification has been detected in 6 examined benign ovarian tumours. The presence of extra copies of myc-related sequences has been shown in two from three DNA samples from peripheral blood leukocytes of patients with ovarian cancer.
D003536:Cystadenocarcinoma / Q000097:blood / Q000235:genetics / Q000556:secondary; D003537:Cystadenoma / Q000097:blood / Q000235:genetics / Q000556:secondary; D004262:DNA Restriction Enzymes; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D006801:Humans; D007962:Leukocytes; D010051:Ovarian Neoplasms / Q000097:blood / Q000235:genetics* / Q000556:secondary; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes
D004273:DNA, Neoplasm; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D004262:DNA Restriction Enzymes
Amplifikatsiia protoonkogena c-myc v pervichnykh opukholiakh, metastazakh i leĭkotsitakh krovi bol'nykh rakom iaichnikov.