Binding of yohimbine and imipramine to platelets in depressive illness.
Radioligand binding to intact platelets was carried out in antidepressant-free patients and the 1 mg dexamethasone suppression test (DST) was performed. There were no differences in binding characteristics between patients and controls for either [3H]yohimbine or [3H]imipramine. There were no differences in binding between patients classified as endogenous using the Newcastle Scale, compared with non-endogenous patients, and no difference between DST suppressors and non-suppressors. The severity of depression did not affect binding values. After 4-6 weeks antidepressant treatment [3H]yohimbine binding was significantly reduced but [3H]imipramine binding was unaffected.
D000328:Adult; D000368:Aged; D000639:Amitriptyline / Q000627:therapeutic use; D001792:Blood Platelets / Q000378:metabolism*; D003866:Depressive Disorder / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D003907:Dexamethasone; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007099:Imipramine / Q000097:blood* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011581:Psychological Tests; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*; D015016:Yohimbine / Q000097:blood*
D011942:Receptors, Adrenergic, alpha; D011985:Receptors, Serotonin; D000639:Amitriptyline; D015016:Yohimbine; D003907:Dexamethasone; D007099:Imipramine; D006854:Hydrocortisone