Plasma renin activity and aldosterone concentration in sodium-depleted cattle following ACTH or metoclopramide injection.
Adrenocorticotropic hormone (ACTH) treatment (7 micrograms X kg-1 body weight) induced an increase in plasma aldosterone concentration in both Na-deficient heifers (following saliva loss after right parotid duct cannulation) and Na-replete heifers, but had no significant effect on plasma renin activity in either of these groups. The dopamine antagonist, metoclopramide, injected i.v. (1 mg X kg-1 body weight) did not modify plasma renin activity, aldosterone or cortisol concentrations in either group. These results indicate that dopamine did not play a major role in the regulation of aldosterone secretion in Na-replete or Na-depleted heifers.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000450:Aldosterone / Q000097:blood*; D000818:Animals; D002417:Cattle / Q000502:physiology*; D005260:Female; D008787:Metoclopramide / Q000494:pharmacology*; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000172:deficiency*
D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D012964:Sodium; D012083:Renin; D008787:Metoclopramide