title: Keratoconus.
abstract: Keratoconus is a bilateral disorder of corneal shape which may be sporadic or genetically determined. Early corneal thinning suggests that a functional loss of structural elements is a primary event in the disease. Tensile strength of the cornea is reduced and is expressed by signs of rupture and scarring in Bowman's layer, scarring in the substantia propria, and rupture of Descemet's membrane. The overall stretching of the cornea results in an increase in curvature while an increased area of the corneal surfaces probably determines the onset and form of Fleischer's ring and the occurrence of endothelial polymegathism. Biochemical studies have shown an increase in collagenolysis and of reduceable collagen cross-links, but there is inconsistent evidence of altered solubility or of hydroxyproline or proteoglycan content. Of recent interest is the characterization of proteoglycan bridges along and between corneal collagen fibrils in keratoconus and the apparent loss of keratan sulphate demonstrated by electron-histochemical and x-ray diffraction techniques. The manner in which this could interfere with corneal strength is discussed.
mesh_terms: D001696:Biomechanical Phenomena; D003315:Cornea / Q000033:anatomy & histology / Q000473:pathology; D006801:Humans; D007640:Keratoconus / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D012016:Reference Values