[Effect of heparin on the pulmonary surfactant system in experimental studies].
Experiments were performed in 9 dogs and 20 rats. The effect of heparin (3-4 mg/kg of the body weight) on the lung surfactant was studied under conditions of bacterial endotoxic shock. Heparin was found to decrease the surfactant content in lungs by 57.6% in intact animals, while under conditions of endotoxic shock by 92.2% as compared with the initial level.
D000818:Animals; D004285:Dogs; D004731:Endotoxins; D006464:Hemoperfusion / Q000379:methods; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D011663:Pulmonary Surfactants / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D051381:Rats; D012131:Respiratory Insufficiency / Q000139:chemically induced; D012764:Shigella sonnei; D012772:Shock, Septic / Q000209:etiology / Q000628:therapy*
D004731:Endotoxins; D011663:Pulmonary Surfactants; D006493:Heparin
Vliianie geparina na surfaktantnuiu sistemu legkikh v éksperimente.